PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2113058-2 1990 We have previously shown that IgM-Asn406, a mutant IgM which has asparagine in place of the serine which is normally found at position 406, also has an abnormally glycosylated mu-chain and is defective in complement-dependent cytolysis. Asparagine 65-75 immunoglobulin heavy constant mu Mus musculus 30-33 2113058-2 1990 We have previously shown that IgM-Asn406, a mutant IgM which has asparagine in place of the serine which is normally found at position 406, also has an abnormally glycosylated mu-chain and is defective in complement-dependent cytolysis. Asparagine 65-75 immunoglobulin heavy constant mu Mus musculus 51-54 2113058-2 1990 We have previously shown that IgM-Asn406, a mutant IgM which has asparagine in place of the serine which is normally found at position 406, also has an abnormally glycosylated mu-chain and is defective in complement-dependent cytolysis. Serine 92-98 immunoglobulin heavy constant mu Mus musculus 30-33 2113058-2 1990 We have previously shown that IgM-Asn406, a mutant IgM which has asparagine in place of the serine which is normally found at position 406, also has an abnormally glycosylated mu-chain and is defective in complement-dependent cytolysis. Serine 92-98 immunoglobulin heavy constant mu Mus musculus 51-54 2113058-7 1990 By comparing IgM made in the presence and absence of deoxymannojirimycin, we show further that the defect in cytolytic activity derives mostly from the abnormal oligosaccharide. 1-Deoxynojirimycin 53-72 immunoglobulin heavy constant mu Mus musculus 13-16 2113058-7 1990 By comparing IgM made in the presence and absence of deoxymannojirimycin, we show further that the defect in cytolytic activity derives mostly from the abnormal oligosaccharide. Oligosaccharides 161-176 immunoglobulin heavy constant mu Mus musculus 13-16 23112425-4 2012 RESULTS: In permeabilized FRT cells, apical chloride current induced by CFTR agonists (10 muM forskolin, 100 muM CPT-cAMP, and 20 muM apigenin) was inhibited by DQA with IC(50) ~ 20 muM and complete inhibition at 200 muM. Colforsin 94-103 CF transmembrane conductance regulator Homo sapiens 72-76 22105697-6 2012 Forskolin, a potent activator of PKA, mimicked, and H89, a pharmacological PKA inhibitor, and PKI, a membrane-permeable PKA peptide PKA inhibitor, attenuated the negative effect of ISO on the A(1)R-mediated PKCepsilon translocation. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 33-36 23047036-10 2012 FSK induced the expression of the IL6 (2.6-fold), IL11 (4.0-fold), chemokine ligand 13 (CXCL13, 2.8-fold) and bone morphogenetic protein 2 (BMP2, 2.5-fold) genes. Colforsin 0-3 interleukin 6 Rattus norvegicus 34-37 22572817-4 2012 alpha-Melanocortin and forskolin, which activate adenylate cyclase, and 12-O-tetradecanoylphorbol-13-acetate, which activates protein kinase C, increased, whereas exposure to UV radiation reduced, MC1R gene and membrane protein expression. Colforsin 23-32 melanocortin 1 receptor Homo sapiens 197-201 22711960-6 2012 Inhibition of CFTR with CFTR(inh172) and transfection with CFTR-specific siRNAs in DC2 cells reduced basal and forskolin-activated ATP release. Colforsin 111-120 cystic fibrosis transmembrane conductance regulator Mus musculus 14-18 23047036-2 2012 We have previously reported that each of FGF2 and forskolin (FSK) alone increase transcription of the bone sialoprotein (BSP) gene, and that together (FGF/FSK) they upregulate BSP gene expression synergistically in rat osteoblast-like ROS 17/2.8 cells. Colforsin 50-59 integrin-binding sialoprotein Rattus norvegicus 102-119 23047036-10 2012 FSK induced the expression of the IL6 (2.6-fold), IL11 (4.0-fold), chemokine ligand 13 (CXCL13, 2.8-fold) and bone morphogenetic protein 2 (BMP2, 2.5-fold) genes. Colforsin 0-3 interleukin 11 Rattus norvegicus 50-54 23047036-2 2012 We have previously reported that each of FGF2 and forskolin (FSK) alone increase transcription of the bone sialoprotein (BSP) gene, and that together (FGF/FSK) they upregulate BSP gene expression synergistically in rat osteoblast-like ROS 17/2.8 cells. Colforsin 50-59 integrin-binding sialoprotein Rattus norvegicus 121-124 23047036-2 2012 We have previously reported that each of FGF2 and forskolin (FSK) alone increase transcription of the bone sialoprotein (BSP) gene, and that together (FGF/FSK) they upregulate BSP gene expression synergistically in rat osteoblast-like ROS 17/2.8 cells. Colforsin 61-64 integrin-binding sialoprotein Rattus norvegicus 102-119 23047036-2 2012 We have previously reported that each of FGF2 and forskolin (FSK) alone increase transcription of the bone sialoprotein (BSP) gene, and that together (FGF/FSK) they upregulate BSP gene expression synergistically in rat osteoblast-like ROS 17/2.8 cells. Colforsin 61-64 integrin-binding sialoprotein Rattus norvegicus 121-124 23047036-10 2012 FSK induced the expression of the IL6 (2.6-fold), IL11 (4.0-fold), chemokine ligand 13 (CXCL13, 2.8-fold) and bone morphogenetic protein 2 (BMP2, 2.5-fold) genes. Colforsin 0-3 C-X-C motif chemokine ligand 13 Rattus norvegicus 88-94 23047036-2 2012 We have previously reported that each of FGF2 and forskolin (FSK) alone increase transcription of the bone sialoprotein (BSP) gene, and that together (FGF/FSK) they upregulate BSP gene expression synergistically in rat osteoblast-like ROS 17/2.8 cells. Colforsin 155-158 integrin-binding sialoprotein Rattus norvegicus 176-179 23047036-5 2012 In ROS17/2.8 cells, FGF2 and FSK each increased the gene expression of c-FOS (7.2-fold and 10.7-fold, respectively). Colforsin 29-32 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 71-76 23047036-10 2012 FSK induced the expression of the IL6 (2.6-fold), IL11 (4.0-fold), chemokine ligand 13 (CXCL13, 2.8-fold) and bone morphogenetic protein 2 (BMP2, 2.5-fold) genes. Colforsin 0-3 bone morphogenetic protein 2 Rattus norvegicus 110-138 23047036-10 2012 FSK induced the expression of the IL6 (2.6-fold), IL11 (4.0-fold), chemokine ligand 13 (CXCL13, 2.8-fold) and bone morphogenetic protein 2 (BMP2, 2.5-fold) genes. Colforsin 0-3 bone morphogenetic protein 2 Rattus norvegicus 140-144 22669740-8 2012 Furthermore, cAMP activation by forskolin up-regulated proglucagon expression by 87% in mHypoE-39 neurons and increased proglucagon mRNA, through Epac activation, in the mHypoE-20/2 neurons. Colforsin 32-41 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 146-150 22684629-0 2012 Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation. Colforsin 35-44 heterogeneous nuclear ribonucleoprotein K Rattus norvegicus 53-60 22684629-2 2012 We isolated a protein kinase A-responsive ribonucleic acid (RNA) element from a 3" splice site of the synaptosomal-associated protein 25 (Snap25) gene for forskolin-inhibited splicing during neuronal differentiation of rat pheochromocytoma PC12 cells. Colforsin 155-164 synaptosome associated protein 25 Rattus norvegicus 102-136 22684629-2 2012 We isolated a protein kinase A-responsive ribonucleic acid (RNA) element from a 3" splice site of the synaptosomal-associated protein 25 (Snap25) gene for forskolin-inhibited splicing during neuronal differentiation of rat pheochromocytoma PC12 cells. Colforsin 155-164 synaptosome associated protein 25 Rattus norvegicus 138-144 22684629-5 2012 We show that such motifs upstream of the Runx1 exon 6 also bind hnRNP K, and importantly, hnRNP K is required for forskolin-induced repression of the exon. Colforsin 114-123 RUNX family transcription factor 1 Rattus norvegicus 41-46 22684629-5 2012 We show that such motifs upstream of the Runx1 exon 6 also bind hnRNP K, and importantly, hnRNP K is required for forskolin-induced repression of the exon. Colforsin 114-123 heterogeneous nuclear ribonucleoprotein K Rattus norvegicus 64-71 22684629-5 2012 We show that such motifs upstream of the Runx1 exon 6 also bind hnRNP K, and importantly, hnRNP K is required for forskolin-induced repression of the exon. Colforsin 114-123 heterogeneous nuclear ribonucleoprotein K Rattus norvegicus 90-97 22684629-7 2012 Consistent with an important role of the target genes in neurons, knocking down hnRNP K severely disrupts forskolin-induced neurite growth. Colforsin 106-115 heterogeneous nuclear ribonucleoprotein K Rattus norvegicus 80-87 22684629-8 2012 Thus, through hnRNP K, the neuronal differentiation stimulus forskolin targets a critical 3" splice site component of the splicing machinery to control alternative splicing of crucial genes. Colforsin 61-70 heterogeneous nuclear ribonucleoprotein K Rattus norvegicus 14-21 22532442-3 2012 Native cellular responses [cAMP elevation, ERK phosphorylation, cAMP responsive element binding (CREB) phosphorylation, and neuritogenesis] and promoter-reporter gene activation after treatment with forskolin, cAMP analogs, and PACAP were measured in Neuroscreen-1 (NS-1) cells, a PC12 variant enabling simultaneous morphological, molecular biological, and biochemical analysis. Colforsin 199-208 cAMP responsive element binding protein 1 Homo sapiens 97-101 22532442-4 2012 Forskolin (25 muM) and cAMP analogs (8-bromo-cAMP, dibutyryl-cAMP, and 8-chlorophenylthio-cAMP) stimulated ERK phosphorylation and neuritogenesis in NS-1 cells. Colforsin 0-9 latexin Homo sapiens 14-17 22532442-4 2012 Forskolin (25 muM) and cAMP analogs (8-bromo-cAMP, dibutyryl-cAMP, and 8-chlorophenylthio-cAMP) stimulated ERK phosphorylation and neuritogenesis in NS-1 cells. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 107-110 22619251-11 2012 With the addition of the phosphodiesterase 4 (PDE4) inhibitor rolipram AC2 accelerated forskolin-stimulated arborization. Colforsin 87-96 phosphodiesterase 4A Homo sapiens 25-44 22619251-11 2012 With the addition of the phosphodiesterase 4 (PDE4) inhibitor rolipram AC2 accelerated forskolin-stimulated arborization. Colforsin 87-96 phosphodiesterase 4A Homo sapiens 46-50 22619251-11 2012 With the addition of the phosphodiesterase 4 (PDE4) inhibitor rolipram AC2 accelerated forskolin-stimulated arborization. Colforsin 87-96 adenylate cyclase 2 Homo sapiens 71-74 22648950-7 2012 FSK-induced K(+) secretion was 1) not inhibited by either mucosal or serosal 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34; a Kcnn4 channel blocker), 2) inhibited (92%) by mucosal iberiotoxin (Kcnma1 channel blocker), and 3) not affected by mucosal cystic fibrosis transmembrane conductance regulator inhibitor (CFTR(inh)-172). Colforsin 0-3 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 137-142 22648950-7 2012 FSK-induced K(+) secretion was 1) not inhibited by either mucosal or serosal 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34; a Kcnn4 channel blocker), 2) inhibited (92%) by mucosal iberiotoxin (Kcnma1 channel blocker), and 3) not affected by mucosal cystic fibrosis transmembrane conductance regulator inhibitor (CFTR(inh)-172). Colforsin 0-3 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 204-210 22648950-7 2012 FSK-induced K(+) secretion was 1) not inhibited by either mucosal or serosal 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34; a Kcnn4 channel blocker), 2) inhibited (92%) by mucosal iberiotoxin (Kcnma1 channel blocker), and 3) not affected by mucosal cystic fibrosis transmembrane conductance regulator inhibitor (CFTR(inh)-172). Colforsin 0-3 CF transmembrane conductance regulator Rattus norvegicus 260-311 22648950-7 2012 FSK-induced K(+) secretion was 1) not inhibited by either mucosal or serosal 1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole (TRAM-34; a Kcnn4 channel blocker), 2) inhibited (92%) by mucosal iberiotoxin (Kcnma1 channel blocker), and 3) not affected by mucosal cystic fibrosis transmembrane conductance regulator inhibitor (CFTR(inh)-172). Colforsin 0-3 CF transmembrane conductance regulator Rattus norvegicus 323-327 22648950-8 2012 By contrast, FSK-induced Cl(-) secretion was 1) completely inhibited by serosal TRAM-34, 2) not inhibited by either mucosal or serosal iberiotoxin, and 3) completely inhibited by mucosal CFTR(inh)-172. Colforsin 13-16 CF transmembrane conductance regulator Rattus norvegicus 187-191 22734036-9 2012 FHL2 also interacts with cAMP response element-binding protein and substantially augments activation of inhibin gene expression by the combination of NR5A receptors and forskolin, suggesting that FHL2 may facilitate integration of these two signals. Colforsin 169-178 four and a half LIM domains 2 Homo sapiens 0-4 22750144-3 2012 Ghrelin suppressed [Ca(2+)](i) responses to an adenylate cyclase activator forskolin. Colforsin 75-84 ghrelin and obestatin prepropeptide Rattus norvegicus 0-7 22931619-5 2012 RESULTS: Compared with the normal control cells, the cells exposed to high glucose and to normal glucose and Forskolin showed a significantly lowered G6PD activity, ROS content and expression of phosphorylated p47(phox), but with a increased cAMP content (P<0.01). Colforsin 109-118 glucose-6-phosphate dehydrogenase Homo sapiens 150-154 22931619-5 2012 RESULTS: Compared with the normal control cells, the cells exposed to high glucose and to normal glucose and Forskolin showed a significantly lowered G6PD activity, ROS content and expression of phosphorylated p47(phox), but with a increased cAMP content (P<0.01). Colforsin 109-118 pleckstrin Homo sapiens 210-213 22556145-13 2012 Forskolin acutely inhibited NHE3 activity in SK-CO15 cells, further attesting the validity of these cells. Colforsin 0-9 solute carrier family 9 member A3 Homo sapiens 28-32 22691551-6 2012 In addition, RFRP-3 inhibited gonadotropin- and forskolin-induced intracellular cAMP accumulation, and these effects were abolished by pretreatment with an inhibitor of inhibitory G(i/o) proteins (pertussis toxin). Colforsin 48-57 neuropeptide VF precursor Homo sapiens 13-17 22517767-8 2012 In the absence of TTX, activation of CaSR with R-568 significantly reduced basal I(sc) and cyclic AMP-stimulated I(sc); it also completely reversed the cAMP-stimulated secretory responses if the drug was applied after the forskolin stimulation. Colforsin 222-231 calcium-sensing receptor Rattus norvegicus 37-41 22691551-7 2012 Importantly, the effects of RFRP-3 on FSH-, LH-, and forskolin-induced cAMP and progesterone accumulation were completely eliminated by cotreatment with the bifunctional GPR147/GPR74 antagonist RF9 or by pretreatment with GPR147 small interfering RNA. Colforsin 53-62 neuropeptide FF receptor 1 Homo sapiens 222-228 22586225-5 2012 Basal and forskolin (FSK)-stimulated JHCO3 - was measured by single-pass perfusion in the duodenum of slc4a7-/- and slc4a7+/+ as well as slc4a5-/- and slc4a5+/+ mice in vivo, and by pH-stat titration in isolated duodenal mucosa in vitro. Colforsin 10-19 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Mus musculus 102-108 22586225-5 2012 Basal and forskolin (FSK)-stimulated JHCO3 - was measured by single-pass perfusion in the duodenum of slc4a7-/- and slc4a7+/+ as well as slc4a5-/- and slc4a5+/+ mice in vivo, and by pH-stat titration in isolated duodenal mucosa in vitro. Colforsin 21-24 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Mus musculus 102-108 22586225-5 2012 Basal and forskolin (FSK)-stimulated JHCO3 - was measured by single-pass perfusion in the duodenum of slc4a7-/- and slc4a7+/+ as well as slc4a5-/- and slc4a5+/+ mice in vivo, and by pH-stat titration in isolated duodenal mucosa in vitro. Colforsin 21-24 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Mus musculus 116-122 22586225-7 2012 Slc4a7-/- mice displayed significantly lower basal and FSK-stimulated duodenal HCO3 - secretion than slc4a7+/+ littermates in vivo. Colforsin 55-58 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Mus musculus 0-6 22586225-8 2012 FSK-stimulated HCO3 - secretion was significantly reduced in slc4a7-/- isolated duodenal mucosa. Colforsin 0-3 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Mus musculus 61-67 22586225-12 2012 The electroneutral Na+:HCO3 - cotransporter NBCn1 (slc4a7) is a major duodenal HCO3 - importer that supplies HCO3 - during basal and FSK-stimulated HCO3 - secretion. Colforsin 133-136 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Mus musculus 44-49 22586225-12 2012 The electroneutral Na+:HCO3 - cotransporter NBCn1 (slc4a7) is a major duodenal HCO3 - importer that supplies HCO3 - during basal and FSK-stimulated HCO3 - secretion. Colforsin 133-136 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Mus musculus 51-57 22691551-7 2012 Importantly, the effects of RFRP-3 on FSH-, LH-, and forskolin-induced cAMP and progesterone accumulation were completely eliminated by cotreatment with the bifunctional GPR147/GPR74 antagonist RF9 or by pretreatment with GPR147 small interfering RNA. Colforsin 53-62 neuropeptide VF precursor Homo sapiens 28-32 22691551-7 2012 Importantly, the effects of RFRP-3 on FSH-, LH-, and forskolin-induced cAMP and progesterone accumulation were completely eliminated by cotreatment with the bifunctional GPR147/GPR74 antagonist RF9 or by pretreatment with GPR147 small interfering RNA. Colforsin 53-62 neuropeptide FF receptor 1 Homo sapiens 170-176 22691551-7 2012 Importantly, the effects of RFRP-3 on FSH-, LH-, and forskolin-induced cAMP and progesterone accumulation were completely eliminated by cotreatment with the bifunctional GPR147/GPR74 antagonist RF9 or by pretreatment with GPR147 small interfering RNA. Colforsin 53-62 neuropeptide FF receptor 2 Homo sapiens 177-182 22375940-5 2012 Gel-shift assays, using nuclear proteins from forskolin-treated hypothalamic 4B cells and CRH promoter CRE oligonucleotides, unmethylated or methylated at CpG1, revealed a strong band that was supershifted by phospho-cAMP response element-binding antibody. Colforsin 46-55 candidate plasticity gene 1 Rattus norvegicus 155-159 22552731-7 2012 As most important pharmacological tool, we used 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene forskolin (BODIPY-FS) that inhibits recombinant AC2 but activates ACs 1 and 5 (Erdorf et al., Biochem Pharmacol 82:1673-1681, 2011). Colforsin 91-100 adenylate cyclase 2 Rattus norvegicus 139-142 22552731-7 2012 As most important pharmacological tool, we used 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene forskolin (BODIPY-FS) that inhibits recombinant AC2 but activates ACs 1 and 5 (Erdorf et al., Biochem Pharmacol 82:1673-1681, 2011). Colforsin 91-100 adenylate cyclase 1 Rattus norvegicus 157-168 22552731-14 2012 The effects of FS and BODIPY-FS were much more prominent in control than in HPRT(-) cells, indicative for a differentiation defect in HPRT deficiency. Colforsin 15-17 hypoxanthine phosphoribosyltransferase 1 Rattus norvegicus 76-80 26105333-11 2012 RESULTS: PlGF mRNA expression increased 3-fold with forskolin in BeWo cells. Colforsin 52-61 placental growth factor Homo sapiens 9-13 22511293-7 2012 Impaired adipocyte differentiation was rescued by an adenylyl cyclase activator, forskolin, and provided evidence that Gsalpha-cAMP signals are necessary in early stages of this process. Colforsin 81-90 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 119-126 22539619-0 2012 Modulation of PC12 cell viability by forskolin-induced cyclic AMP levels through ERK and JNK pathways: an implication for L-DOPA-induced cytotoxicity in nigrostriatal dopamine neurons. Colforsin 37-46 Eph receptor B1 Rattus norvegicus 81-84 22462548-4 2012 However, stimulation with the cAMP-elevating agent forskolin and the beta-adrenergic receptor agonist CL 316,243 resulted in a PKA (protein kinase A)-dependent phosphorylation and 14-3-3 binding of SIK2. Colforsin 51-60 salt inducible kinase 2 Homo sapiens 198-202 22539619-0 2012 Modulation of PC12 cell viability by forskolin-induced cyclic AMP levels through ERK and JNK pathways: an implication for L-DOPA-induced cytotoxicity in nigrostriatal dopamine neurons. Colforsin 37-46 mitogen-activated protein kinase 8 Rattus norvegicus 89-92 22539619-3 2012 The low levels of forskolin (0.01 and 0.1 muM)-induced cAMP increased dopamine biosynthesis and tyrosine hydroxylase (TH) phosphorylation, and induced transient phosphorylation of ERK1/2 within 1 h. However, at the high levels of forskolin (1.0 and 10 muM)-induced cAMP, dopamine biosynthesis and TH phosphorylation did not increase, but rapid differentiation in neurite-like formation was observed with a steady state. Colforsin 18-27 mitogen activated protein kinase 3 Rattus norvegicus 180-186 22539619-4 2012 The high levels of forskolin-induced cAMP also induced sustained increase in ERK1/2 phosphorylation within 0.25-6 h and then led to apoptosis, which was apparently mediated by JNK1/2 and caspase-3 activation. Colforsin 19-28 mitogen activated protein kinase 3 Rattus norvegicus 77-83 22539619-4 2012 The high levels of forskolin-induced cAMP also induced sustained increase in ERK1/2 phosphorylation within 0.25-6 h and then led to apoptosis, which was apparently mediated by JNK1/2 and caspase-3 activation. Colforsin 19-28 caspase 3 Rattus norvegicus 187-196 22539619-6 2012 These results suggest that the low levels of forskolin-induced cAMP increased dopamine biosynthesis in cell survival via transient ERK1/2 phosphorylation. Colforsin 45-54 mitogen activated protein kinase 3 Rattus norvegicus 131-137 22539619-7 2012 In contrast, the high levels of forskolin-induced cAMP induced differentiation via sustained ERK1/2 phosphorylation and then led to apoptosis. Colforsin 32-41 mitogen activated protein kinase 3 Rattus norvegicus 93-99 23552700-7 2012 In addition, RASSF10 is upregulated by cell-cell contact and regulated on promoter level as well as endogenously by forskolin, protein kinase A (PKA) and activator Protein 1 (AP-1), linking RASSF10 to the cAMP signaling pathway. Colforsin 116-125 Ras association domain family member 10 Homo sapiens 13-20 23552700-7 2012 In addition, RASSF10 is upregulated by cell-cell contact and regulated on promoter level as well as endogenously by forskolin, protein kinase A (PKA) and activator Protein 1 (AP-1), linking RASSF10 to the cAMP signaling pathway. Colforsin 116-125 Ras association domain family member 10 Homo sapiens 190-197 22634316-10 2012 Further studies indicated that C/EBP transactivation was increased by the cAMP elevating agent forskolin and formoterol in a beta(2)-adrenoceptor dependent manner. Colforsin 95-104 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 31-36 22575451-5 2012 Expression of GalphasQL or treatment with forskolin or isoproterenol inhibited the radiation-induced expression of the XRCC1 protein, and exogenous expression of XRCC1 abolished the DNA repair-inhibiting effect of forskolin. Colforsin 42-51 X-ray repair cross complementing 1 Homo sapiens 119-124 22575451-5 2012 Expression of GalphasQL or treatment with forskolin or isoproterenol inhibited the radiation-induced expression of the XRCC1 protein, and exogenous expression of XRCC1 abolished the DNA repair-inhibiting effect of forskolin. Colforsin 214-223 X-ray repair cross complementing 1 Homo sapiens 162-167 22290937-7 2012 The neutralization of IL-10 restored liver damage in otherwise ischemia/reperfusion-resistant, forskolin-treated mice. Colforsin 95-104 interleukin 10 Mus musculus 22-27 22575451-6 2012 Forskolin treatment promoted the ubiquitin and proteasome-dependent degradation of the XRCC1 protein, resulting in a significant decrease in the half-life of the protein after gamma-ray irradiation. Colforsin 0-9 X-ray repair cross complementing 1 Homo sapiens 87-92 22575451-7 2012 The effect of forskolin on XRCC1 expression was not inhibited by PKA inhibitor, but 8-pCPT-2"-O-Me-cAMP, an Epac-selective cAMP analog, increased ubiquitination of XRCC1 protein and decreased XRCC1 expression. Colforsin 14-23 X-ray repair cross complementing 1 Homo sapiens 27-32 22514271-3 2012 In a human CD34(+) cell culture model, we show that the adenylyl cyclase agonist forskolin inhibits megakaryocytic differentiation in a protein kinase A-dependent manner. Colforsin 81-90 CD34 molecule Homo sapiens 11-15 22514271-5 2012 Specifically, forskolin acting through protein kinase A-induced E2A down-regulation and enforced expression of E2A overrode the inhibitory effects of forskolin on megakaryopoiesis. Colforsin 14-23 transcription factor 3 Homo sapiens 64-67 22514271-5 2012 Specifically, forskolin acting through protein kinase A-induced E2A down-regulation and enforced expression of E2A overrode the inhibitory effects of forskolin on megakaryopoiesis. Colforsin 150-159 transcription factor 3 Homo sapiens 111-114 22461451-5 2012 Recombinant human chorionic gonadotropin (rhCG) and forskolin (FSK) elicited concentration- and time-dependent induction of 3",5"-cyclic adenosine monophosphate, progesterone (P), and T, as well as the differential expression of Star, Hsd3b6, Hsd17b3, and Srd5a1 messenger RNA levels. Colforsin 52-61 hydroxysteroid 17-beta dehydrogenase 3 Homo sapiens 243-250 22461451-5 2012 Recombinant human chorionic gonadotropin (rhCG) and forskolin (FSK) elicited concentration- and time-dependent induction of 3",5"-cyclic adenosine monophosphate, progesterone (P), and T, as well as the differential expression of Star, Hsd3b6, Hsd17b3, and Srd5a1 messenger RNA levels. Colforsin 52-61 steroid 5 alpha-reductase 1 Homo sapiens 256-262 22461451-5 2012 Recombinant human chorionic gonadotropin (rhCG) and forskolin (FSK) elicited concentration- and time-dependent induction of 3",5"-cyclic adenosine monophosphate, progesterone (P), and T, as well as the differential expression of Star, Hsd3b6, Hsd17b3, and Srd5a1 messenger RNA levels. Colforsin 63-66 hydroxysteroid 17-beta dehydrogenase 3 Homo sapiens 243-250 22461451-5 2012 Recombinant human chorionic gonadotropin (rhCG) and forskolin (FSK) elicited concentration- and time-dependent induction of 3",5"-cyclic adenosine monophosphate, progesterone (P), and T, as well as the differential expression of Star, Hsd3b6, Hsd17b3, and Srd5a1 messenger RNA levels. Colforsin 63-66 steroid 5 alpha-reductase 1 Homo sapiens 256-262 22484028-4 2012 Addition of the gonadotropin analogue human chorionic gonadotropin (hCG) and the adenylate cyclase activator forskolin increased igf3 expression in FG and MV follicles, but had no effect on igf2a or igf2b expression. Colforsin 109-118 insulin-like growth factor 3 Danio rerio 129-133 22484028-4 2012 Addition of the gonadotropin analogue human chorionic gonadotropin (hCG) and the adenylate cyclase activator forskolin increased igf3 expression in FG and MV follicles, but had no effect on igf2a or igf2b expression. Colforsin 109-118 insulin-like growth factor 2a Danio rerio 190-195 22484028-4 2012 Addition of the gonadotropin analogue human chorionic gonadotropin (hCG) and the adenylate cyclase activator forskolin increased igf3 expression in FG and MV follicles, but had no effect on igf2a or igf2b expression. Colforsin 109-118 insulin-like growth factor 2b Danio rerio 199-204 22484028-8 2012 Treatment of FG follicles with recombinant human IGF1, hCG, or forskolin inhibited the induction of caspase-3/7 activity, which was used as a measure of apoptosis. Colforsin 63-72 caspase 3 Homo sapiens 100-109 22484028-9 2012 The effects of hCG and forskolin on caspase-3/7 were attenuated by co-treatment with NVP-AEW54, an IGF1 receptor antagonist. Colforsin 23-32 caspase 3, apoptosis-related cysteine peptidase a Danio rerio 36-45 22484028-9 2012 The effects of hCG and forskolin on caspase-3/7 were attenuated by co-treatment with NVP-AEW54, an IGF1 receptor antagonist. Colforsin 23-32 insulin like growth factor 1 Homo sapiens 99-103 21996743-7 2012 Furthermore, ablation of this population by Forskolin-induced differentiation or MITF-forced expression significantly decreases tumour and metastasis formation, suggesting that eradication of low-MITF cells might improve melanoma treatment. Colforsin 44-53 melanocyte inducing transcription factor Homo sapiens 196-200 22375002-8 2012 CC2D1A associates with the cAMP-PKA complex following forskolin treatment and accumulates in vesicles or on the plasma membrane in wild-type cells, suggesting that CC2D1A may recruit the PKA complex to the membrane to facilitate signal transduction. Colforsin 54-63 coiled-coil and C2 domain containing 1A Mus musculus 0-6 22304689-5 2012 The histamine H1 receptor (H1R) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands, and activation of H1R and H2R signalling by A23187 and forskolin, respectively, had the same effect, indicating that the histamine-induced down-regulation of NKG2D ligands is mediated by H1R and H2R. Colforsin 188-197 histamine receptor H1 Homo sapiens 4-25 22304689-5 2012 The histamine H1 receptor (H1R) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands, and activation of H1R and H2R signalling by A23187 and forskolin, respectively, had the same effect, indicating that the histamine-induced down-regulation of NKG2D ligands is mediated by H1R and H2R. Colforsin 188-197 histamine receptor H1 Homo sapiens 27-30 22304689-5 2012 The histamine H1 receptor (H1R) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands, and activation of H1R and H2R signalling by A23187 and forskolin, respectively, had the same effect, indicating that the histamine-induced down-regulation of NKG2D ligands is mediated by H1R and H2R. Colforsin 188-197 histamine receptor H2 Homo sapiens 64-67 22304689-5 2012 The histamine H1 receptor (H1R) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands, and activation of H1R and H2R signalling by A23187 and forskolin, respectively, had the same effect, indicating that the histamine-induced down-regulation of NKG2D ligands is mediated by H1R and H2R. Colforsin 188-197 killer cell lectin like receptor K1 Homo sapiens 118-123 22304689-5 2012 The histamine H1 receptor (H1R) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands, and activation of H1R and H2R signalling by A23187 and forskolin, respectively, had the same effect, indicating that the histamine-induced down-regulation of NKG2D ligands is mediated by H1R and H2R. Colforsin 188-197 histamine receptor H1 Homo sapiens 151-154 22304689-5 2012 The histamine H1 receptor (H1R) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands, and activation of H1R and H2R signalling by A23187 and forskolin, respectively, had the same effect, indicating that the histamine-induced down-regulation of NKG2D ligands is mediated by H1R and H2R. Colforsin 188-197 histamine receptor H2 Homo sapiens 159-162 22304689-5 2012 The histamine H1 receptor (H1R) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands, and activation of H1R and H2R signalling by A23187 and forskolin, respectively, had the same effect, indicating that the histamine-induced down-regulation of NKG2D ligands is mediated by H1R and H2R. Colforsin 188-197 histamine receptor H1 Homo sapiens 151-154 22304689-5 2012 The histamine H1 receptor (H1R) agonist 2-pyridylethylamine and H2R agonist dimaprit down-regulated the expression of NKG2D ligands, and activation of H1R and H2R signalling by A23187 and forskolin, respectively, had the same effect, indicating that the histamine-induced down-regulation of NKG2D ligands is mediated by H1R and H2R. Colforsin 188-197 histamine receptor H2 Homo sapiens 159-162 22419722-11 2012 MRAP2 expression was suppressed by forskolin (-24 +- 15%, P = 0.013) and PMA (-22 +- 7%, P = 0.0007). Colforsin 35-44 melanocortin 2 receptor accessory protein 2 Homo sapiens 0-5 22270541-9 2012 Forskolin, adenylyl cyclase activator, simulated the effects of ISO on eIF-2alpha phosphorylation. Colforsin 0-9 eukaryotic translation initiation factor 2A Rattus norvegicus 71-81 22490661-4 2012 Whole-cell TRPC5 current was significantly increased by beta-adrenergic receptor agonist, isoproterenol (ISO, 246+-36%, n=6), an activator of the adenylate cyclase, forskolin (FSK, 273+-6%, n=5), or a membrane permeable cAMP analogue, 8-Br-cAMP (251+-63%, n=7). Colforsin 165-174 transient receptor potential cation channel subfamily C member 5 Homo sapiens 11-16 22490661-4 2012 Whole-cell TRPC5 current was significantly increased by beta-adrenergic receptor agonist, isoproterenol (ISO, 246+-36%, n=6), an activator of the adenylate cyclase, forskolin (FSK, 273+-6%, n=5), or a membrane permeable cAMP analogue, 8-Br-cAMP (251+-63%, n=7). Colforsin 176-179 transient receptor potential cation channel subfamily C member 5 Homo sapiens 11-16 22490661-8 2012 Finally, we identified that the membrane localization of TRPC5 was significantly increased by ISO (155+-17%, n=3), FSK (172+-39%, n=3) or 8-Br-cAMP (216+-59%, n=3). Colforsin 115-118 transient receptor potential cation channel subfamily C member 5 Homo sapiens 57-62 22685356-3 2012 Double-immunofluorescence microscopy showed that AQP2 is colocalized with caveolin-1 in the apical plasma membrane by stimulating the intracellular signaling cascade of vasopressin with forskolin. Colforsin 186-195 aquaporin 2 Canis lupus familiaris 49-53 22685356-3 2012 Double-immunofluorescence microscopy showed that AQP2 is colocalized with caveolin-1 in the apical plasma membrane by stimulating the intracellular signaling cascade of vasopressin with forskolin. Colforsin 186-195 caveolin 1 Canis lupus familiaris 74-84 22685356-4 2012 After washing forskolin, both AQP2 and caveolin-1 were internalized to early endosomes and then separately went back to their individual compartments, which are subapical compartments and the apical membrane, respectively.Double-immunogold electron microscopy in ultrathin cryosections confirmed the colocalization of AQP2 with caveolin-1 at caveolar structures on the apical plasma membrane of forskolin-treated cells and the colocalization within the same intracellular vesicles after washing forskolin. Colforsin 14-23 aquaporin 2 Canis lupus familiaris 30-34 22458807-8 2012 This regulation of binding of PP1 and PP2A to PRIP by PKA-dependent phosphorylation was also observed in living cells treated with forskolin or isoproterenol. Colforsin 131-140 inorganic pyrophosphatase 1 Homo sapiens 30-33 22458807-8 2012 This regulation of binding of PP1 and PP2A to PRIP by PKA-dependent phosphorylation was also observed in living cells treated with forskolin or isoproterenol. Colforsin 131-140 protein phosphatase 2 phosphatase activator Homo sapiens 38-42 22458807-8 2012 This regulation of binding of PP1 and PP2A to PRIP by PKA-dependent phosphorylation was also observed in living cells treated with forskolin or isoproterenol. Colforsin 131-140 phospholipase C like 1 (inactive) Homo sapiens 46-50 22344266-5 2012 The LP genes showed distinct dependency on the duration of ERK activity, and they were also induced during the latent process of PACAP- and forskolin-induced cell differentiation. Colforsin 140-149 Eph receptor B1 Rattus norvegicus 59-62 22344266-5 2012 The LP genes showed distinct dependency on the duration of ERK activity, and they were also induced during the latent process of PACAP- and forskolin-induced cell differentiation. Colforsin 140-149 adenylate cyclase activating polypeptide 1 Rattus norvegicus 129-134 22685356-4 2012 After washing forskolin, both AQP2 and caveolin-1 were internalized to early endosomes and then separately went back to their individual compartments, which are subapical compartments and the apical membrane, respectively.Double-immunogold electron microscopy in ultrathin cryosections confirmed the colocalization of AQP2 with caveolin-1 at caveolar structures on the apical plasma membrane of forskolin-treated cells and the colocalization within the same intracellular vesicles after washing forskolin. Colforsin 14-23 caveolin 1 Canis lupus familiaris 39-49 22685356-4 2012 After washing forskolin, both AQP2 and caveolin-1 were internalized to early endosomes and then separately went back to their individual compartments, which are subapical compartments and the apical membrane, respectively.Double-immunogold electron microscopy in ultrathin cryosections confirmed the colocalization of AQP2 with caveolin-1 at caveolar structures on the apical plasma membrane of forskolin-treated cells and the colocalization within the same intracellular vesicles after washing forskolin. Colforsin 395-404 aquaporin 2 Canis lupus familiaris 30-34 22685356-4 2012 After washing forskolin, both AQP2 and caveolin-1 were internalized to early endosomes and then separately went back to their individual compartments, which are subapical compartments and the apical membrane, respectively.Double-immunogold electron microscopy in ultrathin cryosections confirmed the colocalization of AQP2 with caveolin-1 at caveolar structures on the apical plasma membrane of forskolin-treated cells and the colocalization within the same intracellular vesicles after washing forskolin. Colforsin 395-404 caveolin 1 Canis lupus familiaris 39-49 22685356-4 2012 After washing forskolin, both AQP2 and caveolin-1 were internalized to early endosomes and then separately went back to their individual compartments, which are subapical compartments and the apical membrane, respectively.Double-immunogold electron microscopy in ultrathin cryosections confirmed the colocalization of AQP2 with caveolin-1 at caveolar structures on the apical plasma membrane of forskolin-treated cells and the colocalization within the same intracellular vesicles after washing forskolin. Colforsin 395-404 aquaporin 2 Canis lupus familiaris 30-34 22685356-4 2012 After washing forskolin, both AQP2 and caveolin-1 were internalized to early endosomes and then separately went back to their individual compartments, which are subapical compartments and the apical membrane, respectively.Double-immunogold electron microscopy in ultrathin cryosections confirmed the colocalization of AQP2 with caveolin-1 at caveolar structures on the apical plasma membrane of forskolin-treated cells and the colocalization within the same intracellular vesicles after washing forskolin. Colforsin 395-404 caveolin 1 Canis lupus familiaris 39-49 22685356-5 2012 A co-immunoprecipitation experiment showed the close interaction between AQP2 and caveolin-1 in forskolin-treated cells and in cells after washing forskolin. Colforsin 96-105 aquaporin 2 Canis lupus familiaris 73-77 22685356-5 2012 A co-immunoprecipitation experiment showed the close interaction between AQP2 and caveolin-1 in forskolin-treated cells and in cells after washing forskolin. Colforsin 96-105 caveolin 1 Canis lupus familiaris 82-92 22685356-5 2012 A co-immunoprecipitation experiment showed the close interaction between AQP2 and caveolin-1 in forskolin-treated cells and in cells after washing forskolin. Colforsin 147-156 aquaporin 2 Canis lupus familiaris 73-77 22685356-5 2012 A co-immunoprecipitation experiment showed the close interaction between AQP2 and caveolin-1 in forskolin-treated cells and in cells after washing forskolin. Colforsin 147-156 caveolin 1 Canis lupus familiaris 82-92 22238282-10 2012 Silencing of GCM1 prevented the induction of GJA1 mRNA by forskolin in BeWo choriocarcinoma cells, demonstrating that GCM1 is upstream of Cx43. Colforsin 58-67 glial cells missing transcription factor 1 Homo sapiens 13-17 22238282-10 2012 Silencing of GCM1 prevented the induction of GJA1 mRNA by forskolin in BeWo choriocarcinoma cells, demonstrating that GCM1 is upstream of Cx43. Colforsin 58-67 gap junction protein alpha 1 Homo sapiens 45-49 22238282-10 2012 Silencing of GCM1 prevented the induction of GJA1 mRNA by forskolin in BeWo choriocarcinoma cells, demonstrating that GCM1 is upstream of Cx43. Colforsin 58-67 gap junction protein alpha 1 Homo sapiens 138-142 22268508-3 2012 Our results show that PGE2 induces COX-2 and mPGES-1 expression, an effect mimicked by dbcAMP (dibutyryl-cAMP) or forskolin. Colforsin 114-123 prostaglandin E synthase Mus musculus 45-52 22381622-4 2012 YC-1 did not directly cause NO production or iNOS expression, but drastically potentiated PGE1- or forskolin-induced NO production and iNOS expression in NR8383 alveolar macrophages. Colforsin 99-108 glutathione S-transferase alpha 1 Rattus norvegicus 0-4 22381622-4 2012 YC-1 did not directly cause NO production or iNOS expression, but drastically potentiated PGE1- or forskolin-induced NO production and iNOS expression in NR8383 alveolar macrophages. Colforsin 99-108 nitric oxide synthase 2 Rattus norvegicus 135-139 22381622-3 2012 In this study, we investigated the effect of 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1), a known activator of soluble guanylyl cyclase, on prostaglandin (PG)E1 (a stable PGE2 analogue) and forskolin (a adenylate cyclase activator) induced NO production and inducible NO synthase (iNOS) expression in rat alveolar macrophages (NR8383). Colforsin 201-210 glutathione S-transferase alpha 1 Rattus norvegicus 94-98 22405774-6 2012 Phosphorylation of PLB, induced by forskolin, caused an increase in FRET from CFP-SERCA to YFP-PLB, indicating that SERCA inhibition can be relieved without dissociation of the complex. Colforsin 35-44 complement factor properdin Homo sapiens 78-81 22315453-5 2012 We are reporting our studies demonstrating that lentiviral-mediated expression of a gene carrying the T158A mutation of the KCNJ5 in the HAC15 adrenal cortical carcinoma cell line causes a 5.3-fold increase in aldosterone secretion in unstimulated HAC15-KCNJ5 cells and that forskolin-stimulated aldosterone secretion was greater than that of angiotensin II. Colforsin 275-284 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 124-129 22351773-7 2012 Accordingly, myonectin transcript was up-regulated by compounds (forskolin, epinephrine, ionomycin) that raise cellular cAMP or calcium levels. Colforsin 65-74 erythroferrone Mus musculus 13-22 22315453-5 2012 We are reporting our studies demonstrating that lentiviral-mediated expression of a gene carrying the T158A mutation of the KCNJ5 in the HAC15 adrenal cortical carcinoma cell line causes a 5.3-fold increase in aldosterone secretion in unstimulated HAC15-KCNJ5 cells and that forskolin-stimulated aldosterone secretion was greater than that of angiotensin II. Colforsin 275-284 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 254-259 22315453-5 2012 We are reporting our studies demonstrating that lentiviral-mediated expression of a gene carrying the T158A mutation of the KCNJ5 in the HAC15 adrenal cortical carcinoma cell line causes a 5.3-fold increase in aldosterone secretion in unstimulated HAC15-KCNJ5 cells and that forskolin-stimulated aldosterone secretion was greater than that of angiotensin II. Colforsin 275-284 angiotensinogen Homo sapiens 343-357 22116802-10 2012 Studies on the Mmp10 promoter demonstrated that forskolin plus PMA stimulated promoter activity, which was dependent upon a proximal AP1 site. Colforsin 48-57 matrix metallopeptidase 10 Rattus norvegicus 15-20 22344723-6 2012 When both BeWo cell lines were cocultured, forskolin-mediated induction of fusion led to an increase in luciferase activity, which was sensitive to anti-syncytin 1 and -2 antibodies and syncytin 2 small interfering RNAs (siRNAs). Colforsin 43-52 endogenous retrovirus group W member 1, envelope Homo sapiens 153-170 22344723-6 2012 When both BeWo cell lines were cocultured, forskolin-mediated induction of fusion led to an increase in luciferase activity, which was sensitive to anti-syncytin 1 and -2 antibodies and syncytin 2 small interfering RNAs (siRNAs). Colforsin 43-52 endogenous retrovirus group FRD member 1, envelope Homo sapiens 186-196 22159280-12 2012 Forskolin or dibutyryl-cAMP mimics upregulation of iNOS gene expression in macrophages. Colforsin 0-9 nitric oxide synthase 2, inducible Mus musculus 51-55 22311984-7 2012 Exogenous expression of PRIP accelerated the dephosphorylation process of phosphorylated SNAP-25 after forskolin or phorbol ester treatment of the cells. Colforsin 103-112 nuclear receptor coactivator 6 Rattus norvegicus 24-28 22311984-7 2012 Exogenous expression of PRIP accelerated the dephosphorylation process of phosphorylated SNAP-25 after forskolin or phorbol ester treatment of the cells. Colforsin 103-112 synaptosome associated protein 25 Rattus norvegicus 89-96 22311984-8 2012 The phospho-states of SNAP-25 were correlated with noradrenalin secretion, which was enhanced by forskolin or phorbol ester treatment and modulated by PRIP expression in PC12 cells. Colforsin 97-106 synaptosome associated protein 25 Rattus norvegicus 22-29 22269608-6 2012 A potent inhibitor of protein kinase A (PKA), H89 (500 muM), potentiated the 8-Br-cAMP- and forskolin-induced increases in 2,3-DHBA and antagonized the inhibitory effect of 100 nmol of db-cAMP. Colforsin 92-101 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 22-38 22269608-6 2012 A potent inhibitor of protein kinase A (PKA), H89 (500 muM), potentiated the 8-Br-cAMP- and forskolin-induced increases in 2,3-DHBA and antagonized the inhibitory effect of 100 nmol of db-cAMP. Colforsin 92-101 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 40-43 22245830-9 2012 In palmitate-treated vs untreated cells, fsk-stimulated ERK1/2 phosphorylation was reduced by 46% (P=0.0047), but stimulated CYP17 expression was not significantly affected. Colforsin 41-44 mitogen-activated protein kinase 3 Bos taurus 56-62 22178802-6 2012 However, unlike the CFE, intake of 0.05% pure forskolin was found to be associated with only weak induction in CYP3A and GST activities with no significant increases in relative liver weight, total hepatic content or other CYPs activities. Colforsin 46-55 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 111-116 22374202-7 2012 Treatment of cells with the ENaC blocker amiloride and the CFTR activator forskolin increased TER in RV-infected cells, whereas forskolin decreased TER in uninfected cells. Colforsin 74-83 CF transmembrane conductance regulator Homo sapiens 59-63 22178802-6 2012 However, unlike the CFE, intake of 0.05% pure forskolin was found to be associated with only weak induction in CYP3A and GST activities with no significant increases in relative liver weight, total hepatic content or other CYPs activities. Colforsin 46-55 hematopoietic prostaglandin D synthase Mus musculus 121-124 22034075-5 2012 The stable PKD1 shRNA MG-63 cells exhibited lower basal intracellular calcium, which led to attenuated cytosolic calcium signaling in response to fluid flow shear stress, as well as increased intracellular cAMP messages in response to forskolin (10 microM) stimulation. Colforsin 235-244 polycystin 1, transient receptor potential channel interacting Homo sapiens 11-15 22301781-9 2012 The decrease of miR-16 and miR-195 expression by TSH was reproduced by forskolin and N(6),2"-O-dibutyryladenosine cAMP and reversed by the protein kinase A inhibitor H89 and the PI3K inhibitor LY294002. Colforsin 71-80 glycerophosphodiester phosphodiesterase 1 Homo sapiens 16-22 22171090-6 2012 Unlike all known sGC regulators that target the N-terminal regulatory regions, CN2-Cbi directly targets the catalytic domain of sGC, resembling the effect of forskolin on adenylyl cyclases. Colforsin 158-167 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 128-131 22278744-7 2012 In coimmunoprecipitation assays, forskolin stimulated the CFTR/14-3-3beta interaction while reducing CFTR"s interaction with coat protein complex 1 (COP1). Colforsin 33-42 CF transmembrane conductance regulator Homo sapiens 58-62 22278744-7 2012 In coimmunoprecipitation assays, forskolin stimulated the CFTR/14-3-3beta interaction while reducing CFTR"s interaction with coat protein complex 1 (COP1). Colforsin 33-42 CF transmembrane conductance regulator Homo sapiens 101-105 22278744-2 2012 We examined the hypothesis that cAMP/PKA stimulation regulates CFTR biogenesis posttranslationally, based on predicted 14-3-3 binding motifs within CFTR and forskolin-induced CFTR expression. Colforsin 157-166 CF transmembrane conductance regulator Homo sapiens 63-67 22278744-4 2012 Forskolin stimulation (15 min) increased 14-3-3beta and epsilon binding to immature and mature CFTR (bands B and C), and 14-3-3 overexpression increased CFTR bands B and C and cell surface band C. In pulse-chase experiments, 14-3-3beta increased the synthesis of immature CFTR, reduced its degradation rate, and increased conversion of immature to mature CFTR. Colforsin 0-9 CF transmembrane conductance regulator Homo sapiens 95-99 22301781-9 2012 The decrease of miR-16 and miR-195 expression by TSH was reproduced by forskolin and N(6),2"-O-dibutyryladenosine cAMP and reversed by the protein kinase A inhibitor H89 and the PI3K inhibitor LY294002. Colforsin 71-80 microRNA 195 Homo sapiens 27-34 21964403-9 2012 Acute activation of the dopamine D(2) receptor by quinpirole inhibited forskolin-stimulated adenylyl cyclase activity in HASM cells, which was blocked by the dopamine D(2) receptor antagonist L-741626. Colforsin 71-80 dopamine receptor D2 Homo sapiens 24-46 22194610-4 2012 Insulin secretion induced by d-glucose and forskolin is amplified by overexpressing iPLA(2)beta in INS-1 cells and in mouse islets, and the p38 MAPK inhibitor PD169316 prevents both responses. Colforsin 43-52 phospholipase A2 group VI Rattus norvegicus 84-95 23213402-0 2012 AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells. Colforsin 39-48 aquaporin 2 Canis lupus familiaris 0-4 22053093-3 2012 We used the forskolin-induced syncytialization of trophoblastlike BeWo cells to characterize at the cellular level the effect mediated by leukemia inhibitory factor (LIF) on trophoblast differentiation and to describe its action at the molecular level. Colforsin 12-21 LIF interleukin 6 family cytokine Homo sapiens 138-164 22053093-3 2012 We used the forskolin-induced syncytialization of trophoblastlike BeWo cells to characterize at the cellular level the effect mediated by leukemia inhibitory factor (LIF) on trophoblast differentiation and to describe its action at the molecular level. Colforsin 12-21 LIF interleukin 6 family cytokine Homo sapiens 166-169 22053093-4 2012 Forskolin induces both hCG secretion and BeWo cell syncytial fusion. Colforsin 0-9 hypertrichosis 2 (generalised, congenital) Homo sapiens 23-26 22053093-5 2012 Although LIF had no effect on the undifferentiated state of the cells, the cytokine generated a strong reduction in forskolin-induced hCG release. Colforsin 116-125 hypertrichosis 2 (generalised, congenital) Homo sapiens 134-137 22053093-6 2012 In contrast to its effect on hCG secretion, LIF exerts a synergistic effect toward forskolin-induced fusion. Colforsin 83-92 LIF interleukin 6 family cytokine Homo sapiens 44-47 22053093-8 2012 However, both types of signaling molecules were required to mediate the action of LIF in forskolin-induced cell fusion. Colforsin 89-98 LIF interleukin 6 family cytokine Homo sapiens 82-85 22227470-9 2012 Co-treatment with rolipram and forskolin also enhanced CREB phosphorylation on serine 133 that was inhibited by H-89, PKA inhibitor and cAMP-responsive guanine nucleotide exchange factor 1(Epac1), a Rap GDP exchange factor-mediated Rap1 activity in A172 cells. Colforsin 31-40 cAMP responsive element binding protein 1 Homo sapiens 55-59 22227470-9 2012 Co-treatment with rolipram and forskolin also enhanced CREB phosphorylation on serine 133 that was inhibited by H-89, PKA inhibitor and cAMP-responsive guanine nucleotide exchange factor 1(Epac1), a Rap GDP exchange factor-mediated Rap1 activity in A172 cells. Colforsin 31-40 Rap guanine nucleotide exchange factor 3 Homo sapiens 189-194 22227470-9 2012 Co-treatment with rolipram and forskolin also enhanced CREB phosphorylation on serine 133 that was inhibited by H-89, PKA inhibitor and cAMP-responsive guanine nucleotide exchange factor 1(Epac1), a Rap GDP exchange factor-mediated Rap1 activity in A172 cells. Colforsin 31-40 RAP1A, member of RAS oncogene family Homo sapiens 232-236 21957188-6 2012 TGFB1 exposure caused a 70%-99% decrease in basal transepithelial electrical resistance (R(TE), a sensitive indicator of barrier integrity), while a significant decrease in anion secretory response to forskolin was detected at the highest levels of TGFB1 exposure employed. Colforsin 201-210 transforming growth factor beta 1 Homo sapiens 0-5 21964403-9 2012 Acute activation of the dopamine D(2) receptor by quinpirole inhibited forskolin-stimulated adenylyl cyclase activity in HASM cells, which was blocked by the dopamine D(2) receptor antagonist L-741626. Colforsin 71-80 dopamine receptor D2 Homo sapiens 158-180 22186415-9 2012 Effects of VLDL on CYP11B2 transcript levels were not additive with angiotensin II or potassium but were additive with the cAMP pathway agonists ACTH and forskolin. Colforsin 154-163 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 19-26 22568121-2 2012 We evaluated the pharmacological properties of aripiprazole, dopamine D2 receptor partial agonists and antipsychotics using forskolin-stimulated cAMP accumulation in cells expressing human dopamine D2 and D3 receptors. Colforsin 124-133 dopamine receptor D2 Homo sapiens 189-217 21963716-8 2012 These effects of TNF-alpha could be inhibited by stabilizing the microtubules, co-treating with a selective p38 MAP kinase inhibitor, and elevating intracellular cAMP via A2B receptors or direct exposure to forskolin. Colforsin 207-216 tumor necrosis factor Homo sapiens 17-26 21080412-4 2012 This modulation of AMPA currents was mimicked by forskolin (1 muM) and did not occur in stratum radiatum interneurons. Colforsin 49-58 latexin Homo sapiens 62-65 22184064-3 2012 Treatment of transfected human cells with the protein kinase A (PKA) activator forskolin blocked, while kinase inhibition promoted, CCNY-dependent targeting of CDK16-green fluorescent protein (GFP) to the cell membrane. Colforsin 79-88 cyclin Y Homo sapiens 132-136 22184064-3 2012 Treatment of transfected human cells with the protein kinase A (PKA) activator forskolin blocked, while kinase inhibition promoted, CCNY-dependent targeting of CDK16-green fluorescent protein (GFP) to the cell membrane. Colforsin 79-88 cyclin-dependent kinase 16 Mus musculus 160-165 22207716-6 2012 Treatment of these cells with thrombin or agonists for PAR1 or PAR4 decreased basal and forskolin-induced cAMP biosynthesis and suppressed hCG-stimulated progesterone production. Colforsin 88-97 coagulation factor II Mus musculus 30-38 22207716-6 2012 Treatment of these cells with thrombin or agonists for PAR1 or PAR4 decreased basal and forskolin-induced cAMP biosynthesis and suppressed hCG-stimulated progesterone production. Colforsin 88-97 coagulation factor II (thrombin) receptor Mus musculus 55-59 22207716-6 2012 Treatment of these cells with thrombin or agonists for PAR1 or PAR4 decreased basal and forskolin-induced cAMP biosynthesis and suppressed hCG-stimulated progesterone production. Colforsin 88-97 coagulation factor II (thrombin) receptor-like 3 Mus musculus 63-67 22128327-6 2012 In the present study, we show that methylseleninic acid (MSA), a second-generation selenium compound, can effectively suppress aromatase activation by dexamethasone, a synthetic glucocorticoid, and forskolin, a specific activator of adenylate cyclase. Colforsin 198-207 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 127-136 22049213-11 2012 In the rat model, crypts were exposed to 100 muM 3-isobutyl-1-methylxanthine/1 muM forskolin and demonstrated a decrease in NHE4 activity with increased cAMP levels. Colforsin 83-92 solute carrier family 9 member A4 Rattus norvegicus 124-128 22108211-5 2012 Moreover, activation of other IOP lowering, Gs-coupled prostanoid receptors, such as DP1 and IP, as well as a direct activator of adenylyl cyclase, forskolin, also substantially upregulated C6orf176 in hCSM, while FP and TP, which are Gq-coupled prostanoid receptor subtypes, did not. Colforsin 148-157 long intergenic non-protein coding RNA 473 Homo sapiens 190-198 22219298-4 2012 The impairment in LTP was rescued by the application of forskolin, an adenylyl cyclase activator, or more robust stimulation, suggesting that cAMP/protein kinase A signaling was suppressed in these mice. Colforsin 56-65 cathelicidin antimicrobial peptide Mus musculus 142-146 22185778-7 2012 The binding of Daxx to CREB correlates with its repressive effect on a CRE-mediated reporter activity induced by forskolin or PKA. Colforsin 113-122 death domain associated protein Homo sapiens 15-19 22453982-5 2012 When forskolin (10 muM), an AC stimulator was added to RBC suspension, the RBC deformability was increased (p <0.05). Colforsin 5-14 latexin Homo sapiens 19-22 21964404-6 2012 Here, we demonstrate that bupivacaine and quinidine, blockers of four-transmembrane domain, two-pore potassium (K2P) channels, inhibit both amiloride-sensitive sodium absorption and forskolin-stimulated anion secretion in polarized, normal human bronchial epithelial cells at lower concentrations when applied to the mucosal surface than when applied to the serosal surface. Colforsin 182-191 keratin 76 Homo sapiens 112-115 22185778-7 2012 The binding of Daxx to CREB correlates with its repressive effect on a CRE-mediated reporter activity induced by forskolin or PKA. Colforsin 113-122 cAMP responsive element binding protein 1 Homo sapiens 23-27 22109884-6 2012 In 4B hypothalamic neurons, or primary cultures, SIK1 mRNA (but not SIK2 mRNA) was inducible by the cAMP stimulator, forskolin. Colforsin 117-126 salt-inducible kinase 1 Rattus norvegicus 49-53 21964154-4 2012 We also used electrophysiological methods to assess the functional contribution of NKCC and CFTR to forskolin-activated I(SC) responses in filter grown cultured monolayers. Colforsin 100-109 cystic fibrosis transmembrane conductance regulator Gallus gallus 92-96 21964154-8 2012 Two selective CFTR blockers, CFTR Inhibitor 172 and GlyH-101 (both at 20 muM) inhibited the forskolin activated diffusion currents by 38-68%, with GlyH-101 having a greater effect. Colforsin 92-101 cystic fibrosis transmembrane conductance regulator Gallus gallus 14-18 21964154-8 2012 Two selective CFTR blockers, CFTR Inhibitor 172 and GlyH-101 (both at 20 muM) inhibited the forskolin activated diffusion currents by 38-68%, with GlyH-101 having a greater effect. Colforsin 92-101 cystic fibrosis transmembrane conductance regulator Gallus gallus 29-33 22109890-6 2012 Results of immunoblot and immunofluorescence experiments reveal that TSH and forskolin rapidly increase pendrin abundance at the plasma membrane through the protein kinase A pathway in PCCL-3 rat thyroid cells. Colforsin 77-86 solute carrier family 26 member 4 Rattus norvegicus 104-111 22759971-11 2012 cAMP elevation by a physiologic agonist, isoproterenol, mimicked the results obtained with forskolin or 8-pCPT-2"-O-Me-cAMP. Colforsin 91-100 cathelicidin antimicrobial peptide Homo sapiens 0-4 22109884-7 2012 Overexpression of either SIK1 or SIK2 in 4B cells reduced nuclear TORC2 levels (Western blot) and inhibited forskolin-stimulated CRH transcription (luciferase assay). Colforsin 108-117 corticotropin releasing hormone Rattus norvegicus 129-132 22109886-6 2012 The effects of GHRH/ghrelin were completely mimicked by forskolin (adenylate cyclase activator) and phorbol 12-myristate 13-acetate (protein kinase C activator), respectively, indicating the regulation of receptor subtype levels by GHRH and ghrelin involved distinct signaling pathways. Colforsin 56-65 somatoliberin Papio anubis 15-19 22109886-6 2012 The effects of GHRH/ghrelin were completely mimicked by forskolin (adenylate cyclase activator) and phorbol 12-myristate 13-acetate (protein kinase C activator), respectively, indicating the regulation of receptor subtype levels by GHRH and ghrelin involved distinct signaling pathways. Colforsin 56-65 somatoliberin Papio anubis 232-236 22848794-4 2012 The KSO peptide inhibited forskolin-stimulated cyclic adenosine monophosphate (cAMP) production in ND7/23 neuroblastoma cells via an action that could be inhibited by the NPFF receptor antagonist RF9. Colforsin 26-35 neuropeptide FF-amide peptide precursor Mus musculus 171-175 22001259-7 2012 The ROCE was inhibited by forskolin and papaverine to activate the cAMP/PKA pathway, whereas it was potentiated by Rp-8-bromoadenosine-cAMP sodium salt, a PKA inhibitor. Colforsin 26-35 cathelicidin antimicrobial peptide Homo sapiens 67-71 21975601-4 2012 PACAP signaling to the STC1 gene proceeded through the extracellular signal-regulated kinases 1 and 2(ERK1/2), but not through the cAMP-dependent protein kinase (PKA), and was mimicked by the adenylate cyclase activator forskolin. Colforsin 220-229 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 21975601-4 2012 PACAP signaling to the STC1 gene proceeded through the extracellular signal-regulated kinases 1 and 2(ERK1/2), but not through the cAMP-dependent protein kinase (PKA), and was mimicked by the adenylate cyclase activator forskolin. Colforsin 220-229 stanniocalcin 1 Rattus norvegicus 23-27 21975601-4 2012 PACAP signaling to the STC1 gene proceeded through the extracellular signal-regulated kinases 1 and 2(ERK1/2), but not through the cAMP-dependent protein kinase (PKA), and was mimicked by the adenylate cyclase activator forskolin. Colforsin 220-229 mitogen activated protein kinase 3 Rattus norvegicus 55-101 21975601-5 2012 PACAP- and forskolin-mediated activation of ERK1/2 occurred through cAMP, but not PKA.These results suggest that STC1 gene induction proceeds through cAMP and ERK1/2, independently of PKA, the canonical cAMP effector. Colforsin 11-20 mitogen activated protein kinase 3 Rattus norvegicus 44-50 21975601-5 2012 PACAP- and forskolin-mediated activation of ERK1/2 occurred through cAMP, but not PKA.These results suggest that STC1 gene induction proceeds through cAMP and ERK1/2, independently of PKA, the canonical cAMP effector. Colforsin 11-20 stanniocalcin 1 Rattus norvegicus 113-117 21975601-5 2012 PACAP- and forskolin-mediated activation of ERK1/2 occurred through cAMP, but not PKA.These results suggest that STC1 gene induction proceeds through cAMP and ERK1/2, independently of PKA, the canonical cAMP effector. Colforsin 11-20 mitogen activated protein kinase 3 Rattus norvegicus 159-165 22850613-3 2012 To test this hypothesis, we selected the approach of activating AC5 activity in mice with a selective AC5 activator (NKH477) or inhibitor (vidarabine) and examining heart rate variability during parabolic flight. Colforsin 117-123 adenylate cyclase 5 Mus musculus 64-67 21547533-5 2012 Both peptides (0.001-1 muM) inhibited, in a concentration-dependent manner and IC(50) values in low nanomolar range, the increase in the nucleotide production evoked by forskolin (1 muM; a direct activator of adenylyl cyclase), pituitary adenylate cyclase-activating polypeptide (PACAP27; 0.1 muM), and vasoactive intestinal peptide (VIP; 3 muM). Colforsin 169-178 adenylate cyclase activating polypeptide 1 Rattus norvegicus 228-296 21547533-5 2012 Both peptides (0.001-1 muM) inhibited, in a concentration-dependent manner and IC(50) values in low nanomolar range, the increase in the nucleotide production evoked by forskolin (1 muM; a direct activator of adenylyl cyclase), pituitary adenylate cyclase-activating polypeptide (PACAP27; 0.1 muM), and vasoactive intestinal peptide (VIP; 3 muM). Colforsin 169-178 vasoactive intestinal peptide Rattus norvegicus 303-332 21547533-5 2012 Both peptides (0.001-1 muM) inhibited, in a concentration-dependent manner and IC(50) values in low nanomolar range, the increase in the nucleotide production evoked by forskolin (1 muM; a direct activator of adenylyl cyclase), pituitary adenylate cyclase-activating polypeptide (PACAP27; 0.1 muM), and vasoactive intestinal peptide (VIP; 3 muM). Colforsin 169-178 vasoactive intestinal peptide Rattus norvegicus 334-337 21547533-6 2012 Effects of orexin A on forskolin-, PACAP27-, and VIP-stimulated cyclic AMP synthesis were blocked by TCS OX2 29 (a selective antagonist of OX(2)R), and unaffected by SB 408124 (a selective antagonist of OX(1)R). Colforsin 23-32 hypocretin neuropeptide precursor Rattus norvegicus 11-19 21547533-7 2012 Pretreatment of neuronal cell cultures with pertussis toxin (PTX) abolished the inhibitory action of orexin A on forskolin- and PACAP-stimulated cyclic AMP accumulation. Colforsin 113-122 hypocretin neuropeptide precursor Rattus norvegicus 101-109 22001259-8 2012 The inhibitory effects of forskolin and papaverine were partially cancelled by replacing Ser28 (TRPC6(S28A)) but not Thr69 (TRPC6(T69A)) of TRPC6 with alanine. Colforsin 26-35 transient receptor potential cation channel subfamily C member 6 Homo sapiens 96-101 23272190-4 2012 Using cultured rat hippocampal neurons, we found that muting induction did not require protein synthesis; however, slow forms of unmuting that depend on protein kinase A (PKA), including reversal of depolarization-induced muting and forskolin-induced unmuting of basally mute synapses, required protein synthesis. Colforsin 233-242 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 171-174 23226244-5 2012 The cAMP/PKA pathway was involved in the signal transduction pathway for CFTR-regulated ATP release from muscle: forskolin increased CFTR phosphorylation and stimulated ATP release from muscle or myocytes; lactic acid increased intracellular cAMP, pCREB and PKA activity, whereas IBMX enhanced ATP release from myocytes. Colforsin 113-122 CF transmembrane conductance regulator Rattus norvegicus 73-77 23226244-5 2012 The cAMP/PKA pathway was involved in the signal transduction pathway for CFTR-regulated ATP release from muscle: forskolin increased CFTR phosphorylation and stimulated ATP release from muscle or myocytes; lactic acid increased intracellular cAMP, pCREB and PKA activity, whereas IBMX enhanced ATP release from myocytes. Colforsin 113-122 CF transmembrane conductance regulator Rattus norvegicus 133-137 22870256-5 2012 This induction of Plk2 expression was mimicked by both forskolin and phorbol 12 myristate 13-acetate (PMA). Colforsin 55-64 polo-like kinase 2 Rattus norvegicus 18-22 23155436-7 2012 Results of these cumulative studies showed that basal and forskolin stimulated steady state CYP11A1 mRNA abundance and CYP11A1 promoter activity were increased in PCOS theca cells. Colforsin 58-67 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 92-99 23155436-7 2012 Results of these cumulative studies showed that basal and forskolin stimulated steady state CYP11A1 mRNA abundance and CYP11A1 promoter activity were increased in PCOS theca cells. Colforsin 58-67 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 119-126 22912664-4 2012 Down regulation of GRP78 by siRNA or chemical inhibitors and use of antibodies against GRP78 in culture medium significantly decreased forskolin-induced fusion capacity of Bewo cells suggesting the involvement of membrane GRP78 in trophoblast fusion. Colforsin 135-144 heat shock protein family A (Hsp70) member 5 Homo sapiens 19-24 22912664-4 2012 Down regulation of GRP78 by siRNA or chemical inhibitors and use of antibodies against GRP78 in culture medium significantly decreased forskolin-induced fusion capacity of Bewo cells suggesting the involvement of membrane GRP78 in trophoblast fusion. Colforsin 135-144 heat shock protein family A (Hsp70) member 5 Homo sapiens 87-92 22912664-4 2012 Down regulation of GRP78 by siRNA or chemical inhibitors and use of antibodies against GRP78 in culture medium significantly decreased forskolin-induced fusion capacity of Bewo cells suggesting the involvement of membrane GRP78 in trophoblast fusion. Colforsin 135-144 heat shock protein family A (Hsp70) member 5 Homo sapiens 87-92 23185487-8 2012 Finally, phosphorylation of cAMP-response element binding protein (CREB) and up-regulation of CREB target genes by GC were inhibited by RCAN1 disruption, and treatment with a cAMP-inducing agent, forskolin, restored the sensitivity to GC in RCAN1-disrupted Nalm-6 cells. Colforsin 196-205 cAMP responsive element binding protein 1 Homo sapiens 67-71 23185487-8 2012 Finally, phosphorylation of cAMP-response element binding protein (CREB) and up-regulation of CREB target genes by GC were inhibited by RCAN1 disruption, and treatment with a cAMP-inducing agent, forskolin, restored the sensitivity to GC in RCAN1-disrupted Nalm-6 cells. Colforsin 196-205 cAMP responsive element binding protein 1 Homo sapiens 94-98 23185487-8 2012 Finally, phosphorylation of cAMP-response element binding protein (CREB) and up-regulation of CREB target genes by GC were inhibited by RCAN1 disruption, and treatment with a cAMP-inducing agent, forskolin, restored the sensitivity to GC in RCAN1-disrupted Nalm-6 cells. Colforsin 196-205 regulator of calcineurin 1 Homo sapiens 241-246 21832167-8 2011 Down-regulation of TIMP2 expression by MEHP exposure is blocked by forskolin (a cAMP-elevating agent), suggesting that the decrease in Sertoli cell TIMP2 expression following MEHP exposure is cAMP-dependent. Colforsin 67-76 TIMP metallopeptidase inhibitor 2 Rattus norvegicus 19-24 22615911-6 2012 Additionally, PCB 126 suppressed forskolin-stimulated gluconeogenesis from lactate. Colforsin 33-42 pyruvate carboxylase Mus musculus 14-17 22615911-9 2012 In concordance with this finding, PCB 126 blunted the forskolin-stimulated increase in phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels without affecting glucose-6-phosphatase expression. Colforsin 54-63 pyruvate carboxylase Mus musculus 34-37 22615911-9 2012 In concordance with this finding, PCB 126 blunted the forskolin-stimulated increase in phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels without affecting glucose-6-phosphatase expression. Colforsin 54-63 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 87-120 22615911-9 2012 In concordance with this finding, PCB 126 blunted the forskolin-stimulated increase in phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels without affecting glucose-6-phosphatase expression. Colforsin 54-63 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 122-127 22403735-10 2012 Consistent with these results, biotinylation experiments in MCD4 cells revealed that membrane AQP2 expression in unstimulated cells exposed to CaR agonists was higher than in control cells and did not increase significantly in response to short term exposure to forskolin (FK). Colforsin 262-271 aquaporin 2 Homo sapiens 94-98 22403735-10 2012 Consistent with these results, biotinylation experiments in MCD4 cells revealed that membrane AQP2 expression in unstimulated cells exposed to CaR agonists was higher than in control cells and did not increase significantly in response to short term exposure to forskolin (FK). Colforsin 262-271 calcium sensing receptor Homo sapiens 143-146 22057271-9 2011 Forskolin-stimulated RGS2 mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the CREB-RGS2 promoter interaction, and Ang II-induced CREB phosphorylation and nuclear localization are blocked by iPLA(2)beta pharmacologic inhibition or genetic ablation. Colforsin 0-9 regulator of G protein signaling 2 Homo sapiens 21-25 22057271-9 2011 Forskolin-stimulated RGS2 mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the CREB-RGS2 promoter interaction, and Ang II-induced CREB phosphorylation and nuclear localization are blocked by iPLA(2)beta pharmacologic inhibition or genetic ablation. Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 61-65 22057271-9 2011 Forskolin-stimulated RGS2 mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the CREB-RGS2 promoter interaction, and Ang II-induced CREB phosphorylation and nuclear localization are blocked by iPLA(2)beta pharmacologic inhibition or genetic ablation. Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 110-119 22057271-9 2011 Forskolin-stimulated RGS2 mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the CREB-RGS2 promoter interaction, and Ang II-induced CREB phosphorylation and nuclear localization are blocked by iPLA(2)beta pharmacologic inhibition or genetic ablation. Colforsin 0-9 angiotensinogen Homo sapiens 146-152 22057271-9 2011 Forskolin-stimulated RGS2 mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the CREB-RGS2 promoter interaction, and Ang II-induced CREB phosphorylation and nuclear localization are blocked by iPLA(2)beta pharmacologic inhibition or genetic ablation. Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 110-114 22057271-9 2011 Forskolin-stimulated RGS2 mRNA up-regulation is inhibited by CREB sequestration or specific disruption of the CREB-RGS2 promoter interaction, and Ang II-induced CREB phosphorylation and nuclear localization are blocked by iPLA(2)beta pharmacologic inhibition or genetic ablation. Colforsin 0-9 phospholipase A2 group VI Homo sapiens 222-233 22057271-12 2011 Point mutations corresponding to these single nucleotide polymorphisms interfere with stimulation of human RGS2 promoter activity by forskolin. Colforsin 133-142 regulator of G protein signaling 2 Homo sapiens 107-111 22662224-12 2012 Accordingly, only females exhibited an increased rate of forskolin-stimulated lipolysis in AT associated with significantly higher glycerol concentrations, lower RER-values, and increased AT expression of adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL). Colforsin 57-66 patatin-like phospholipase domain containing 2 Mus musculus 205-232 22662224-12 2012 Accordingly, only females exhibited an increased rate of forskolin-stimulated lipolysis in AT associated with significantly higher glycerol concentrations, lower RER-values, and increased AT expression of adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL). Colforsin 57-66 patatin-like phospholipase domain containing 2 Mus musculus 234-238 22662224-12 2012 Accordingly, only females exhibited an increased rate of forskolin-stimulated lipolysis in AT associated with significantly higher glycerol concentrations, lower RER-values, and increased AT expression of adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL). Colforsin 57-66 lipase, hormone sensitive Mus musculus 244-268 22662224-12 2012 Accordingly, only females exhibited an increased rate of forskolin-stimulated lipolysis in AT associated with significantly higher glycerol concentrations, lower RER-values, and increased AT expression of adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL). Colforsin 57-66 lipase, hormone sensitive Mus musculus 270-273 22509362-5 2012 Brief challenges with 15 mM glucose or 30 microM forskolin after 2 hour fasting further increased the level of pCREB and consequently induced the persistent expression of ICER. Colforsin 49-58 cAMP responsive element modulator Rattus norvegicus 171-175 22509362-7 2012 In contrast, when islets were grown in 5 mM (low) glucose, CREB was transiently activated in response to glucose or forskolin stimuli. Colforsin 116-125 cAMP responsive element binding protein 1 Rattus norvegicus 59-63 22347403-6 2012 In the cAMP accumulation assay, 135PAM1 inhibits the CRE response to forskolin with a pIC50 of 6.12 (5.98 to 6.27) in the presence of a probe (10 nM) concentration of relaxin-3(NH2). Colforsin 69-78 F11 receptor Homo sapiens 35-39 22347403-6 2012 In the cAMP accumulation assay, 135PAM1 inhibits the CRE response to forskolin with a pIC50 of 6.12 (5.98 to 6.27) in the presence of a probe (10 nM) concentration of relaxin-3(NH2). Colforsin 69-78 relaxin 3 Homo sapiens 167-176 21832167-8 2011 Down-regulation of TIMP2 expression by MEHP exposure is blocked by forskolin (a cAMP-elevating agent), suggesting that the decrease in Sertoli cell TIMP2 expression following MEHP exposure is cAMP-dependent. Colforsin 67-76 TIMP metallopeptidase inhibitor 2 Rattus norvegicus 148-153 21750265-5 2011 The high basal cAMP level most likely reflects an increased cAMP generation in GK/Par compared with W islets since 1) forskolin dose-dependently induced an exaggerated cAMP accumulation; 2) adenylyl cyclase (AC)2, AC3, and G(s)alpha proteins were overexpressed; 3) IBMX-activated cAMP accumulation was less efficient and PDE-3B and PDE-1C mRNA were decreased. Colforsin 118-127 adenylate cyclase 3 Rattus norvegicus 214-217 21234673-9 2011 These functional alterations were driven by elevated cAMP, as direct activation of adenylate cyclase by forskolin elicited similar alterations in VEGF and IL-6 production. Colforsin 104-113 vascular endothelial growth factor A Homo sapiens 146-150 21234673-9 2011 These functional alterations were driven by elevated cAMP, as direct activation of adenylate cyclase by forskolin elicited similar alterations in VEGF and IL-6 production. Colforsin 104-113 interleukin 6 Homo sapiens 155-159 23268452-6 2011 IL-6 production in the supernatants of confluent monolayers cultured in the presence of the drugs or forskolin (24 h) was analyzed by enzyme-linked immunosorbent assay. Colforsin 101-110 interleukin 6 Homo sapiens 0-4 21623993-3 2011 Syndecan-1 was silenced by siRNA to evaluate its involvement in the forskolin-mediated syncytia formation. Colforsin 68-77 syndecan 1 Homo sapiens 0-10 21623993-7 2011 Silencing of the syndecan-1 expression in BeWo cells led to a significant decrease in cell fusion both in the presence and in the absence of forskolin. Colforsin 141-150 syndecan 1 Homo sapiens 17-27 21302311-8 2011 Forskolin and bnz-cAMP also attenuated LPS-induced increase in MLC phosphorylation level. Colforsin 0-9 modulator of VRAC current 1 Homo sapiens 63-66 21908610-7 2011 Finally, the use of a phospho-specific antibody demonstrates that endogenous DUSP9/MKP-4 is phosphorylated on Ser-58 in response to the PKA agonist forskolin and is also modified in placental tissue. Colforsin 148-157 dual specificity phosphatase 9 Homo sapiens 77-82 21908610-7 2011 Finally, the use of a phospho-specific antibody demonstrates that endogenous DUSP9/MKP-4 is phosphorylated on Ser-58 in response to the PKA agonist forskolin and is also modified in placental tissue. Colforsin 148-157 dual specificity phosphatase 9 Homo sapiens 83-88 21832250-5 2011 Exogenous ATP, 5"-N-ethylcarboxamido-adenosine (NECA), a nonselective P1 receptor agonist, or forskolin (FSK) increased caspase-1 activity in rMC-1 cells cultured in control glucose (5 mM) medium. Colforsin 94-103 caspase 1 Rattus norvegicus 120-129 21832250-5 2011 Exogenous ATP, 5"-N-ethylcarboxamido-adenosine (NECA), a nonselective P1 receptor agonist, or forskolin (FSK) increased caspase-1 activity in rMC-1 cells cultured in control glucose (5 mM) medium. Colforsin 105-108 caspase 1 Rattus norvegicus 120-129 21750265-5 2011 The high basal cAMP level most likely reflects an increased cAMP generation in GK/Par compared with W islets since 1) forskolin dose-dependently induced an exaggerated cAMP accumulation; 2) adenylyl cyclase (AC)2, AC3, and G(s)alpha proteins were overexpressed; 3) IBMX-activated cAMP accumulation was less efficient and PDE-3B and PDE-1C mRNA were decreased. Colforsin 118-127 phosphodiesterase 3B Rattus norvegicus 321-327 21832250-9 2011 The increased caspase-1 activity stimulated by high glucose, FSK, NECA, or ATP was correlated with increased gene expression of caspase-1 and thioredoxin-interacting-protein (TXNIP). Colforsin 61-64 caspase 1 Rattus norvegicus 14-23 21832250-9 2011 The increased caspase-1 activity stimulated by high glucose, FSK, NECA, or ATP was correlated with increased gene expression of caspase-1 and thioredoxin-interacting-protein (TXNIP). Colforsin 61-64 caspase 1 Rattus norvegicus 128-137 21832250-9 2011 The increased caspase-1 activity stimulated by high glucose, FSK, NECA, or ATP was correlated with increased gene expression of caspase-1 and thioredoxin-interacting-protein (TXNIP). Colforsin 61-64 thioredoxin interacting protein Rattus norvegicus 142-173 21750265-5 2011 The high basal cAMP level most likely reflects an increased cAMP generation in GK/Par compared with W islets since 1) forskolin dose-dependently induced an exaggerated cAMP accumulation; 2) adenylyl cyclase (AC)2, AC3, and G(s)alpha proteins were overexpressed; 3) IBMX-activated cAMP accumulation was less efficient and PDE-3B and PDE-1C mRNA were decreased. Colforsin 118-127 phosphodiesterase 1C Rattus norvegicus 332-338 21832250-9 2011 The increased caspase-1 activity stimulated by high glucose, FSK, NECA, or ATP was correlated with increased gene expression of caspase-1 and thioredoxin-interacting-protein (TXNIP). Colforsin 61-64 thioredoxin interacting protein Rattus norvegicus 175-180 21798341-4 2011 Activation of cAMP by forskolin (10 muM) reversed the inhibitory effects of mIFN-alpha (1000 U/ml) on dexamethasone (DEX)-induced MMTV-luciferase activity in hippocampal HT22 cells. Colforsin 22-31 interferon alpha Mus musculus 76-86 21798341-5 2011 Forskolin treatment also blocked both IFN-alpha-induced activation of phosphorylated STAT5 (pSTAT5) and inhibitory protein-protein interactions between pSTAT5 and GR in the nucleus of HT22 cells treated with IFN-alpha and DEX. Colforsin 0-9 interferon alpha Mus musculus 38-47 22011961-5 2011 The aim of this study was to evaluate the ability of pentoxifylline, forskolin, rolipram, and thalidomide to decrease in vitro production of TNF-alpha and IFN-gamma in cells of HTLV-1-infected subjects. Colforsin 69-78 tumor necrosis factor Homo sapiens 141-150 21798341-5 2011 Forskolin treatment also blocked both IFN-alpha-induced activation of phosphorylated STAT5 (pSTAT5) and inhibitory protein-protein interactions between pSTAT5 and GR in the nucleus of HT22 cells treated with IFN-alpha and DEX. Colforsin 0-9 signal transducer and activator of transcription 5A Mus musculus 85-90 22011961-5 2011 The aim of this study was to evaluate the ability of pentoxifylline, forskolin, rolipram, and thalidomide to decrease in vitro production of TNF-alpha and IFN-gamma in cells of HTLV-1-infected subjects. Colforsin 69-78 interferon gamma Homo sapiens 155-164 21798341-5 2011 Forskolin treatment also blocked both IFN-alpha-induced activation of phosphorylated STAT5 (pSTAT5) and inhibitory protein-protein interactions between pSTAT5 and GR in the nucleus of HT22 cells treated with IFN-alpha and DEX. Colforsin 0-9 interferon alpha Mus musculus 208-217 21917251-11 2011 RESULT(S): The AMH decreased gonadotropin-stimulated aromatase expression and decreased forskolin-stimulated aromatase in KGN cells and this effect was through a dose-dependent inhibition of promoter II. Colforsin 88-97 anti-Mullerian hormone Homo sapiens 15-18 21734191-4 2011 This current could be inhibited by a membrane-permeable analog of cAMP, 8-bromo-cAMP, by isoproterenol, by a constitutively active form of Galpha(s) [Galpha(s) (Q227L)], and by forskolin. Colforsin 177-186 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 139-148 21969302-5 2011 RESULTS: Results demonstrate that SLHMG cells transcribe and translate VIP and mACh receptors; VIP, with either IBMX or forskolin, activates the adenylyl cyclase pathway, and the effect of VIP and forskolin together is synergistic; both VIP and carbachol increase intracellular [Ca2+] in SLHMG cells; and VIP with forskolin stimulates SLHMG cell proliferation. Colforsin 120-129 vasoactive intestinal peptide Homo sapiens 95-98 21969302-5 2011 RESULTS: Results demonstrate that SLHMG cells transcribe and translate VIP and mACh receptors; VIP, with either IBMX or forskolin, activates the adenylyl cyclase pathway, and the effect of VIP and forskolin together is synergistic; both VIP and carbachol increase intracellular [Ca2+] in SLHMG cells; and VIP with forskolin stimulates SLHMG cell proliferation. Colforsin 120-129 vasoactive intestinal peptide Homo sapiens 95-98 21969302-5 2011 RESULTS: Results demonstrate that SLHMG cells transcribe and translate VIP and mACh receptors; VIP, with either IBMX or forskolin, activates the adenylyl cyclase pathway, and the effect of VIP and forskolin together is synergistic; both VIP and carbachol increase intracellular [Ca2+] in SLHMG cells; and VIP with forskolin stimulates SLHMG cell proliferation. Colforsin 120-129 vasoactive intestinal peptide Homo sapiens 95-98 21969302-5 2011 RESULTS: Results demonstrate that SLHMG cells transcribe and translate VIP and mACh receptors; VIP, with either IBMX or forskolin, activates the adenylyl cyclase pathway, and the effect of VIP and forskolin together is synergistic; both VIP and carbachol increase intracellular [Ca2+] in SLHMG cells; and VIP with forskolin stimulates SLHMG cell proliferation. Colforsin 120-129 vasoactive intestinal peptide Homo sapiens 95-98 21803969-8 2011 Adenylyl cyclase activator forskolin or 8-bromo-cAMP treatment mimicked the action of rimonabant, suggesting that Galpha(i/o) inhibition causes repression of SREBP-1c by increasing the cAMP level. Colforsin 27-36 sterol regulatory element binding transcription factor 1 Homo sapiens 158-166 21871511-9 2011 Clenbuterol and forskolin caused downregulation of cytokines and chemokines such as IL-6 and MCP-1. Colforsin 16-25 interleukin 6 Mus musculus 84-88 21871511-9 2011 Clenbuterol and forskolin caused downregulation of cytokines and chemokines such as IL-6 and MCP-1. Colforsin 16-25 mast cell protease 1 Mus musculus 93-98 21474433-2 2011 Application of capsaicin (100 muM) attenuated vectorial anion transport, estimated as short-circuit currents (I(SC)), before and after stimulation by forskolin (10 muM) with concomitant reduction of cytosolic cyclic AMP (cAMP) levels. Colforsin 150-159 latexin Homo sapiens 164-167 21474433-7 2011 Forskolin application also increased phosphorylated myosin phosphatase target subunit 1, and the phosphorylation was prevented by capsaicin and capsazepine, suggesting that these capsaicinoids assume aspects of Rho kinase inhibitors. Colforsin 0-9 protein phosphatase 1 regulatory subunit 12A Homo sapiens 52-87 21843633-8 2011 Although alpha-tocopherol and alpha-tocopheryl phosphate did not directly bind CB1R, both alpha-TP and CB1R agonists inhibited forskolin-evoked Erk1/2 phosphorylation in a nonadditive manner. Colforsin 127-136 cannabinoid receptor 1 Homo sapiens 103-107 21843633-8 2011 Although alpha-tocopherol and alpha-tocopheryl phosphate did not directly bind CB1R, both alpha-TP and CB1R agonists inhibited forskolin-evoked Erk1/2 phosphorylation in a nonadditive manner. Colforsin 127-136 mitogen-activated protein kinase 3 Homo sapiens 144-150 21908547-4 2011 Forskolin-induced neurite outgrowth is mediated by activation of the PKA signalling pathway and this PKA-mediated neurite outgrowth is achieved by the expression of nur77 in PC12 cells. Colforsin 0-9 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 165-170 21743028-4 2011 Forskolin (5 muM) or trypsin (2 muM), applied in the pipette solution, increased the P(o) and number of channels in ATII cells of wild-type, Cftr(+/-), and DeltaF508, but not in Cftr(-/-) mice, suggesting that the latter were maximally activated. Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 141-145 21743028-4 2011 Forskolin (5 muM) or trypsin (2 muM), applied in the pipette solution, increased the P(o) and number of channels in ATII cells of wild-type, Cftr(+/-), and DeltaF508, but not in Cftr(-/-) mice, suggesting that the latter were maximally activated. Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 178-182 21734191-4 2011 This current could be inhibited by a membrane-permeable analog of cAMP, 8-bromo-cAMP, by isoproterenol, by a constitutively active form of Galpha(s) [Galpha(s) (Q227L)], and by forskolin. Colforsin 177-186 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 150-159 21620962-5 2011 Raising endogenous cAMP (by use of forskolin or inhibition of phosphodiesterase [PDE] 4) or a PKA-selective, but not an Epac-selective, cAMP analogue, increases CTLA-2alpha mRNA expression; PKA, and not Epac, thus mediates the increase in CTLA-2alpha expression. Colforsin 35-44 cathelicidin antimicrobial peptide Mus musculus 19-23 21338323-5 2011 Pre-incubation with metformin (24 h, 1 mM) inhibited forskolin-, isoproterenol-, IBMX-, LPS-, IL-1beta- and TNF-alpha-induced glycerol release and prevented p(Ser554)HSL decrease and p(Ser-552)HSL increase due to lipolytic and inflammatory agents. Colforsin 53-62 tumor necrosis factor Homo sapiens 108-117 21519968-6 2011 The inhibitory effect of EETs on forskolin-mediated cAMP production was abolished when cells were treated with a sEH inhibitor (tAUCB). Colforsin 33-42 epoxide hydrolase 2 Homo sapiens 113-116 21734258-9 2011 However, RLN activation of RXFP1 induced a dose-dependent cAMP response, which when mimicked by forskolin also caused significantly increased (P < 0.05) secretion of IL6. Colforsin 96-105 relaxin family peptide receptor 1 Homo sapiens 27-32 21734258-9 2011 However, RLN activation of RXFP1 induced a dose-dependent cAMP response, which when mimicked by forskolin also caused significantly increased (P < 0.05) secretion of IL6. Colforsin 96-105 interleukin 6 Homo sapiens 169-172 21790603-5 2011 Forskolin treatment stimulated luciferase activity driven by the ~4 kb promoter construct and by all 5"-deletion constructs except the smallest, Aanat (-217 to +120)luc. Colforsin 0-9 aralkylamine N-acetyltransferase Gallus gallus 145-150 21786155-10 2011 This effect was wholly abolished in macrophages pretreated with exendin(9-39) or (Pro(3))GIP, or with an adenylate cyclase inhibitor, MDL12,330A, and was mimicked by incubation with an adenylate cyclase activator, forskolin. Colforsin 214-223 gastric inhibitory polypeptide Mus musculus 89-92 21790603-6 2011 Maximal basal and forskolin-stimulated expression levels were generated by the Aanat (-484 to +120)luc construct. Colforsin 18-27 aralkylamine N-acetyltransferase Gallus gallus 79-84 21790603-8 2011 Electrophoretic mobility shift assays, luciferase reporter assays, chromatin immunoprecipitation, and siRNA experiments provide evidence that these elements bind c-Fos, JunD, and CREB to enhance basal and forskolin-stimulated Aanat transcription. Colforsin 205-214 JunD proto-oncogene, AP-1 transcription factor subunit Gallus gallus 169-173 21790603-8 2011 Electrophoretic mobility shift assays, luciferase reporter assays, chromatin immunoprecipitation, and siRNA experiments provide evidence that these elements bind c-Fos, JunD, and CREB to enhance basal and forskolin-stimulated Aanat transcription. Colforsin 205-214 aralkylamine N-acetyltransferase Gallus gallus 226-231 21730204-7 2011 CoPo-22 also activated wild-type and G551D CFTR chloride conductance within minutes in a forskolin-dependent manner. Colforsin 89-98 CF transmembrane conductance regulator Homo sapiens 43-47 21802725-6 2011 Forskolin treated BeWo cells showed significantly increased DLX3 mRNA and protein expression. Colforsin 0-9 distal-less homeobox 3 Homo sapiens 60-64 21991573-7 2011 After treatment with forskolin for 12 or 24 hours, the number of p-CREB (Ser133) and AQP5 positive cells increased, p-CREB (Ser133) and AQP5 protein increased, and AQP5 mRNA was increased. Colforsin 21-30 cAMP responsive element binding protein 1 Rattus norvegicus 67-71 21991573-7 2011 After treatment with forskolin for 12 or 24 hours, the number of p-CREB (Ser133) and AQP5 positive cells increased, p-CREB (Ser133) and AQP5 protein increased, and AQP5 mRNA was increased. Colforsin 21-30 aquaporin 5 Rattus norvegicus 85-89 21991573-7 2011 After treatment with forskolin for 12 or 24 hours, the number of p-CREB (Ser133) and AQP5 positive cells increased, p-CREB (Ser133) and AQP5 protein increased, and AQP5 mRNA was increased. Colforsin 21-30 cAMP responsive element binding protein 1 Rattus norvegicus 118-122 21991573-7 2011 After treatment with forskolin for 12 or 24 hours, the number of p-CREB (Ser133) and AQP5 positive cells increased, p-CREB (Ser133) and AQP5 protein increased, and AQP5 mRNA was increased. Colforsin 21-30 aquaporin 5 Rattus norvegicus 136-140 21991573-7 2011 After treatment with forskolin for 12 or 24 hours, the number of p-CREB (Ser133) and AQP5 positive cells increased, p-CREB (Ser133) and AQP5 protein increased, and AQP5 mRNA was increased. Colforsin 21-30 aquaporin 5 Rattus norvegicus 136-140 21991573-8 2011 CONCLUSION: Both H89 (PKA inhibitor) and forskolin (cAMP inducing medicine) regulate AQP5 production through the cAMP-PKA/CREB pathway, which could influence the secretory function of the submucosal glands in nasal epithelium. Colforsin 41-50 aquaporin 5 Rattus norvegicus 85-89 21991573-8 2011 CONCLUSION: Both H89 (PKA inhibitor) and forskolin (cAMP inducing medicine) regulate AQP5 production through the cAMP-PKA/CREB pathway, which could influence the secretory function of the submucosal glands in nasal epithelium. Colforsin 41-50 cAMP responsive element binding protein 1 Rattus norvegicus 122-126 21784856-6 2011 Furthermore, association of endogenous sgk1 with the apical cell membrane of mpkCCD(c14) cells could be modulated by treatments that increase or decrease ENaC expression at the apical membrane; forskolin increased the association of sgk1 with the apical surface, whereas methyl-beta-cyclodextrin decreased the association of sgk1 with the apical surface. Colforsin 194-203 serum/glucocorticoid regulated kinase 1 Mus musculus 39-43 21835914-5 2011 PKA activation with forskolin acutely induced genes that promote cholesterol uptake (LDL receptor) and biosynthesis (HMG-CoA reductase). Colforsin 20-29 low density lipoprotein receptor Mus musculus 85-97 21835914-9 2011 Inhibition of both pathways simultaneously using mevastatin-treated Ldlr(-/-) cells did inhibit forskolin-induced matrix mineralization. Colforsin 96-105 low density lipoprotein receptor Mus musculus 68-72 21496886-9 2011 When the adipocytes were treated with cilostazol in combination with isoproterenol or forskolin, the inhibitory effect of cilostazol on PAI-1 gene expression was counteracted, thus suggesting that inhibition by cilostazol may not be the result of intracellular cAMP accumulation by phosphodiesterase inhibition. Colforsin 86-95 serpin family E member 1 Homo sapiens 136-141 21784856-6 2011 Furthermore, association of endogenous sgk1 with the apical cell membrane of mpkCCD(c14) cells could be modulated by treatments that increase or decrease ENaC expression at the apical membrane; forskolin increased the association of sgk1 with the apical surface, whereas methyl-beta-cyclodextrin decreased the association of sgk1 with the apical surface. Colforsin 194-203 sodium channel, nonvoltage-gated 1 alpha Mus musculus 154-158 21784856-6 2011 Furthermore, association of endogenous sgk1 with the apical cell membrane of mpkCCD(c14) cells could be modulated by treatments that increase or decrease ENaC expression at the apical membrane; forskolin increased the association of sgk1 with the apical surface, whereas methyl-beta-cyclodextrin decreased the association of sgk1 with the apical surface. Colforsin 194-203 serum/glucocorticoid regulated kinase 1 Mus musculus 233-237 21784856-6 2011 Furthermore, association of endogenous sgk1 with the apical cell membrane of mpkCCD(c14) cells could be modulated by treatments that increase or decrease ENaC expression at the apical membrane; forskolin increased the association of sgk1 with the apical surface, whereas methyl-beta-cyclodextrin decreased the association of sgk1 with the apical surface. Colforsin 194-203 serum/glucocorticoid regulated kinase 1 Mus musculus 233-237 21633078-3 2011 In the HSG cells stably transfected with a wild-type mouse AQP5 construct, a protein band immunoreactive with antibody against phosphorylated PKA substrate was detected in the AQP5 immunoprecipitated sample, and its intensity was enhanced by short-term treatment of the cells with 8-bromo-cAMP, forskolin, or phorbol 12-myristate 13-acetate, but not by that with A23187 calcium ionophore. Colforsin 295-304 aquaporin 5 Mus musculus 59-63 21633078-7 2011 Furthermore, both AQP5 and AQP5-T259A were constitutively localized at the plasma membrane in HSG cells under the resting and forskolin-stimulated conditions. Colforsin 126-135 aquaporin 5 Mus musculus 18-22 21633078-7 2011 Furthermore, both AQP5 and AQP5-T259A were constitutively localized at the plasma membrane in HSG cells under the resting and forskolin-stimulated conditions. Colforsin 126-135 aquaporin 5 Mus musculus 27-31 21539938-4 2011 Furthermore, we found that agonist-mediated inhibition of the forskolin-induced cAMP production was dramatically diminished in the CB2 mutant W5.43(194)Y, whereas W5.43(194)F and W5.43(194)A mutants resulted in complete elimination of downstream signaling, suggesting that W5.43(194) was essential for the full activation of CB2. Colforsin 62-71 cannabinoid receptor 2 Homo sapiens 131-134 21596132-6 2011 Serine (Ser) 276 phosphorylation of p65 was increased by LPS-mediated PKA activation or by the treatment with forskolin, adenylate cyclase activator and dibutyl-cAMP. Colforsin 110-119 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-39 21539938-4 2011 Furthermore, we found that agonist-mediated inhibition of the forskolin-induced cAMP production was dramatically diminished in the CB2 mutant W5.43(194)Y, whereas W5.43(194)F and W5.43(194)A mutants resulted in complete elimination of downstream signaling, suggesting that W5.43(194) was essential for the full activation of CB2. Colforsin 62-71 cannabinoid receptor 2 Homo sapiens 325-328 21306750-7 2011 Insulin secretion induced by the protein kinase A (PKA) activators forskolin and 3-isobutyl-1-methyl-xanthine, in the presence of 11.1 mmol/L glucose, was lower in LDLR(-/-) islets and was normalized in the presence of the protein kinase C pathway activators carbachol and phorbol 12-myristate 13-acetate. Colforsin 67-76 low density lipoprotein receptor Mus musculus 164-168 21480364-0 2011 Transcriptional and post-transcriptional down-regulation of cyclin D1 contributes to C6 glioma cell differentiation induced by forskolin. Colforsin 127-136 cyclin D1 Homo sapiens 60-69 21480364-2 2011 Here, we have elaborated that a PKA activator, forskolin, represses cell growth via cell cycle arrest in the G0/G1 phase and induces cell differentiation characteristic with elongated processes and restoration of GFAP expression. Colforsin 47-56 glial fibrillary acidic protein Homo sapiens 213-217 21480364-3 2011 In mechanisms, we verified that forskolin significantly diminishes the mRNA and protein level of a key cell cycle regulator cyclin D1, and maintenance of low cyclin D1 expression level was required for forskolin-induced proliferation inhibition and differentiation by gain and loss of function approaches. Colforsin 32-41 cyclin D1 Homo sapiens 124-133 21480364-3 2011 In mechanisms, we verified that forskolin significantly diminishes the mRNA and protein level of a key cell cycle regulator cyclin D1, and maintenance of low cyclin D1 expression level was required for forskolin-induced proliferation inhibition and differentiation by gain and loss of function approaches. Colforsin 202-211 cyclin D1 Homo sapiens 124-133 21480364-3 2011 In mechanisms, we verified that forskolin significantly diminishes the mRNA and protein level of a key cell cycle regulator cyclin D1, and maintenance of low cyclin D1 expression level was required for forskolin-induced proliferation inhibition and differentiation by gain and loss of function approaches. Colforsin 202-211 cyclin D1 Homo sapiens 158-167 21480364-4 2011 In addition, that forskolin down-regulated the cyclin D1 by proteolytic (post-transcriptional) mechanisms was dependent on GSK-3beta activation at Ser9. Colforsin 18-27 cyclin D1 Homo sapiens 47-56 21480364-4 2011 In addition, that forskolin down-regulated the cyclin D1 by proteolytic (post-transcriptional) mechanisms was dependent on GSK-3beta activation at Ser9. Colforsin 18-27 glycogen synthase kinase 3 beta Homo sapiens 123-132 22024847-7 2011 RESULTS: The change in short-circuit current (DeltaI(SC) in microamperes per square centimeter) attributable to CFTR (forskolin-stimulated) was significantly decreased due to a 12-hour hypoxia exposure in both MNSE (13.55 +- 0.46 vs. 19.23 +- 0.18) and HSNE (19.55 +- 0.56 vs. 25.49 +- 1.48 [control]; P < .05). Colforsin 119-128 CF transmembrane conductance regulator Homo sapiens 113-117 21371008-6 2011 LPS, PGE(2) or forskolin selectively increased MMP-1, MMP-9, MMP-10, MMP-12 and MMP-14 mRNAs. Colforsin 15-24 matrix metallopeptidase 1 Homo sapiens 47-52 21371008-6 2011 LPS, PGE(2) or forskolin selectively increased MMP-1, MMP-9, MMP-10, MMP-12 and MMP-14 mRNAs. Colforsin 15-24 matrix metallopeptidase 9 Homo sapiens 54-59 21371008-6 2011 LPS, PGE(2) or forskolin selectively increased MMP-1, MMP-9, MMP-10, MMP-12 and MMP-14 mRNAs. Colforsin 15-24 matrix metallopeptidase 10 Homo sapiens 61-67 21371008-6 2011 LPS, PGE(2) or forskolin selectively increased MMP-1, MMP-9, MMP-10, MMP-12 and MMP-14 mRNAs. Colforsin 15-24 matrix metallopeptidase 12 Homo sapiens 69-75 21371008-6 2011 LPS, PGE(2) or forskolin selectively increased MMP-1, MMP-9, MMP-10, MMP-12 and MMP-14 mRNAs. Colforsin 15-24 matrix metallopeptidase 14 Homo sapiens 80-86 21698527-8 2011 Forskolin (0.05 and 1 mM) acted in synergy with FGF-2 and EGF; however, it caused pronounced donor to donor differences in the increase of cAMP and phospho-CREB levels. Colforsin 0-9 fibroblast growth factor 2 Homo sapiens 48-53 21698527-8 2011 Forskolin (0.05 and 1 mM) acted in synergy with FGF-2 and EGF; however, it caused pronounced donor to donor differences in the increase of cAMP and phospho-CREB levels. Colforsin 0-9 epidermal growth factor Homo sapiens 58-61 21698527-8 2011 Forskolin (0.05 and 1 mM) acted in synergy with FGF-2 and EGF; however, it caused pronounced donor to donor differences in the increase of cAMP and phospho-CREB levels. Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 156-160 21622533-5 2011 Cotransfection experiments in JEG-3 cells point out that the StarD7 promoter is activated by SF-1, and this effect is increased by forskolin. Colforsin 131-140 StAR related lipid transfer domain containing 7 Homo sapiens 61-67 21733996-5 2011 To assess protein kinase A (PKA) pathway involvement, a pharmacological approach was used with forskolin (FSK) (10 muM), an activator, and H89 (10 muM), an inhibitor of the PKA pathway. Colforsin 106-109 latexin Homo sapiens 115-118 21733996-6 2011 RESULTS: FSK treatment amplified CYP17 mRNA levels in both cell types when compared with basal, with levels increasing over time, peaking at 72 h, and appearing more robust in primary cells; this difference ranged from 2- to 10-fold and was statistically significant at all time points. Colforsin 9-12 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 33-38 21867980-7 2011 Serosal (basolateral) administration of bumetanide, an inhibitor of both NKCC1 and NKCC2, inhibited serosal forskolin-induced I(SC) increase by 66% but enhanced the luminal (apical) forskolin-induced I(SC) response by 63%. Colforsin 108-117 solute carrier family 12 member 2 Rattus norvegicus 73-78 21867980-7 2011 Serosal (basolateral) administration of bumetanide, an inhibitor of both NKCC1 and NKCC2, inhibited serosal forskolin-induced I(SC) increase by 66% but enhanced the luminal (apical) forskolin-induced I(SC) response by 63%. Colforsin 108-117 solute carrier family 12 member 1 Rattus norvegicus 83-88 21622533-5 2011 Cotransfection experiments in JEG-3 cells point out that the StarD7 promoter is activated by SF-1, and this effect is increased by forskolin. Colforsin 131-140 splicing factor 1 Homo sapiens 93-97 21596928-8 2011 By contrast, forskolin inhibited HuR shuttling and destabilized PAR-3 mRNA, thus reducing PAR-3 mRNA and protein expression. Colforsin 13-22 ELAV like RNA binding protein 1 Homo sapiens 33-36 21596928-8 2011 By contrast, forskolin inhibited HuR shuttling and destabilized PAR-3 mRNA, thus reducing PAR-3 mRNA and protein expression. Colforsin 13-22 coagulation factor II thrombin receptor like 2 Homo sapiens 64-69 21596928-8 2011 By contrast, forskolin inhibited HuR shuttling and destabilized PAR-3 mRNA, thus reducing PAR-3 mRNA and protein expression. Colforsin 13-22 coagulation factor II thrombin receptor like 2 Homo sapiens 90-95 21740543-9 2011 Furthermore, forskolin, which activates mitogen-activated protein kinase kinase (MEK), enhanced [125I]hAbeta(1-40) elimination from mouse brain. Colforsin 13-22 midkine Mus musculus 40-79 21693142-5 2011 STC1 induction was similar for all three receptor splice variants and was mimicked by the adenylate cyclase activator forskolin, indicating that cAMP elevation is sufficient to induce STC1. Colforsin 118-127 stanniocalcin 1 Rattus norvegicus 0-4 21693142-5 2011 STC1 induction was similar for all three receptor splice variants and was mimicked by the adenylate cyclase activator forskolin, indicating that cAMP elevation is sufficient to induce STC1. Colforsin 118-127 cathelicidin antimicrobial peptide Rattus norvegicus 145-149 21708133-10 2011 Both basal and forskolin-stimulated fluid secretion in pancreatic ducts transfected with CFTR specific siRNAs were reduced by ~50% compared to fluid secretion from ducts transfected with scrambled negative control dsRNAs. Colforsin 15-24 cystic fibrosis transmembrane conductance regulator Cavia porcellus 89-93 21693142-5 2011 STC1 induction was similar for all three receptor splice variants and was mimicked by the adenylate cyclase activator forskolin, indicating that cAMP elevation is sufficient to induce STC1. Colforsin 118-127 stanniocalcin 1 Rattus norvegicus 184-188 21562093-5 2011 Activation of the cAMP pathway with dibutyryl cAMP (db cAMP) or forskolin recapitulated the stimulatory effect of hCG on leptin expression. Colforsin 64-73 hypertrichosis 2 (generalised, congenital) Homo sapiens 114-117 21549179-4 2011 Up-regulation of low-threshold current by forskolin was mimicked by the protein kinase A (PKA) agonist Sp-cAMPs and the inflammatory mediator serotonin, and blocked by the PKA antagonist Rp-cAMPs. Colforsin 42-51 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 72-88 21549179-4 2011 Up-regulation of low-threshold current by forskolin was mimicked by the protein kinase A (PKA) agonist Sp-cAMPs and the inflammatory mediator serotonin, and blocked by the PKA antagonist Rp-cAMPs. Colforsin 42-51 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 90-93 21549179-4 2011 Up-regulation of low-threshold current by forskolin was mimicked by the protein kinase A (PKA) agonist Sp-cAMPs and the inflammatory mediator serotonin, and blocked by the PKA antagonist Rp-cAMPs. Colforsin 42-51 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 172-175 21740543-9 2011 Furthermore, forskolin, which activates mitogen-activated protein kinase kinase (MEK), enhanced [125I]hAbeta(1-40) elimination from mouse brain. Colforsin 13-22 midkine Mus musculus 81-84 21740543-10 2011 Forskolin also enhanced [125I]hAbeta(1-40) internalization in TM-BBB4 cells, and this enhancement was inhibited by a MEK inhibitor, suggesting involvement of non-genomic action. Colforsin 0-9 midkine Mus musculus 117-120 21623172-11 2011 Leptin also reduced insulin secretion in the presence of 1mM forskolin or 1mM dibutyryl cyclic AMP. Colforsin 61-70 insulin Mesocricetus auratus 20-27 21466834-10 2011 Our results suggest that the forskolin induced PKA/GSK3beta activation protects the EC barrier via TIMAP-mediated decreasing of the ERM phosphorylation level. Colforsin 29-38 glycogen synthase kinase 3 beta Bos taurus 51-59 21466834-10 2011 Our results suggest that the forskolin induced PKA/GSK3beta activation protects the EC barrier via TIMAP-mediated decreasing of the ERM phosphorylation level. Colforsin 29-38 protein phosphatase 1 regulatory subunit 16B Bos taurus 99-104 21411725-4 2011 Iodide effluxes were used to monitor the presence of VIP-rescued functional F508del-CFTR channels at the surface of JME/CF15 cells maintained at 37 C. Iodide efflux peaks measured in response to stimulation with forskolin were insensitive to PKC alpha, beta, gamma, delta, zeta inhibitors. Colforsin 212-221 vasoactive intestinal peptide Homo sapiens 53-56 21466834-8 2011 PKA activation by forskolin treatment of EC prevented thrombin evoked barrier dysfunction and ERM phosphorylation at the cell membrane (Csortos et al., 2008). Colforsin 18-27 coagulation factor II, thrombin Bos taurus 54-62 21466834-9 2011 With the employment of specific GSK3beta inhibitor it is shown here that PKA activation is followed by GSK3beta activation in bovine pulmonary EC and both of these activations are required for the rescuing effect of forskolin in thrombin treated EC. Colforsin 216-225 glycogen synthase kinase 3 beta Bos taurus 32-40 21466834-9 2011 With the employment of specific GSK3beta inhibitor it is shown here that PKA activation is followed by GSK3beta activation in bovine pulmonary EC and both of these activations are required for the rescuing effect of forskolin in thrombin treated EC. Colforsin 216-225 glycogen synthase kinase 3 beta Bos taurus 103-111 21466834-9 2011 With the employment of specific GSK3beta inhibitor it is shown here that PKA activation is followed by GSK3beta activation in bovine pulmonary EC and both of these activations are required for the rescuing effect of forskolin in thrombin treated EC. Colforsin 216-225 coagulation factor II, thrombin Bos taurus 229-237 21392518-5 2011 Chromatin immunoprecipitation demonstrated endogenous LRH-1 occupancy on PII under basal conditions and with treatment with forskolin and phorbol 12-myristate 13-acetate (PMA). Colforsin 124-133 nuclear receptor subfamily 5 group A member 2 Homo sapiens 54-59 21561868-9 2011 Basal and dexamethasone-stimulated NHE3 activity of Clcn5 KO mice was decreased compared with that seen in WT mice, whereas the degree of inhibition of NHE3 activity by increasing cellular concentration of cAMP (forskolin) or Ca(2+) (A23187) was not different in WT and Clcn5 KO mice. Colforsin 212-221 solute carrier family 9 (sodium/hydrogen exchanger), member 3 Mus musculus 152-156 21414336-8 2011 Using PCR to amplify promoter-specific transcripts of aromatase, it appears that the inhibition of the FSK/PMA-mediated expression of aromatase is due to decreases in PII/PI.3-specific transcripts, whereas no effect of metformin is observed on any promoter-specific transcript, including PI.4, in DEX/TNFalpha-treated hASCs. Colforsin 103-106 tumor necrosis factor Homo sapiens 301-309 21389275-8 2011 Conversely, the adenylyl cyclase activator forskolin abolished the AMPK phosphorylation response induced by TSH withdrawal in PCCL3 cells. Colforsin 43-52 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 67-71 21386061-5 2011 We found that consumption of a high-protein diet that increased serum glucagon concentration or the administration of glucagon or incubation of hepatocytes with forskolin increased the SNAT2 mRNA level. Colforsin 161-170 solute carrier family 38, member 2 Rattus norvegicus 185-190 21622113-3 2011 H4R agonist reduced cyclic adenosine monophosphate (cAMP) formation induced by forskolin only in MCF-7 cells. Colforsin 79-88 histamine receptor H4 Homo sapiens 0-3 21186937-6 2011 For human subcutaneous adipocytes, isoproterenol, forskolin, and ANP activated HSL phosphorylation/colocalization, but Lys-gamma3-melanocyte stimulating hormone had little or no effect. Colforsin 50-59 lipase E, hormone sensitive type Homo sapiens 79-82 21490976-7 2011 Brief treatment of mixed neuronal/glial POA cultures with PGE2 or the cAMP/PKA stimulator, forskolin, increased membrane associated GluR1 in both neurons and glia. Colforsin 91-100 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 75-78 21612641-7 2011 The TGF-beta1 stimulation of alpha-SMA, CTGF, COL1A2 and COL3A1 was greatly inhibited by concomitant treatment with forskolin, especially in DC-derived cells. Colforsin 116-125 transforming growth factor beta 1 Homo sapiens 4-13 21612641-7 2011 The TGF-beta1 stimulation of alpha-SMA, CTGF, COL1A2 and COL3A1 was greatly inhibited by concomitant treatment with forskolin, especially in DC-derived cells. Colforsin 116-125 cellular communication network factor 2 Homo sapiens 40-44 21612641-7 2011 The TGF-beta1 stimulation of alpha-SMA, CTGF, COL1A2 and COL3A1 was greatly inhibited by concomitant treatment with forskolin, especially in DC-derived cells. Colforsin 116-125 collagen type I alpha 2 chain Homo sapiens 46-52 21612641-7 2011 The TGF-beta1 stimulation of alpha-SMA, CTGF, COL1A2 and COL3A1 was greatly inhibited by concomitant treatment with forskolin, especially in DC-derived cells. Colforsin 116-125 collagen type III alpha 1 chain Homo sapiens 57-63 21656370-5 2011 Here we show that wild-type and mutant A30P and A53T alpha-SYN attenuate forskolin-induced TH up-regulation, but do not suppress TH basal expression in SK-N-BE(2)C cells. Colforsin 73-82 synuclein alpha Homo sapiens 53-62 21656370-5 2011 Here we show that wild-type and mutant A30P and A53T alpha-SYN attenuate forskolin-induced TH up-regulation, but do not suppress TH basal expression in SK-N-BE(2)C cells. Colforsin 73-82 tyrosine hydroxylase Homo sapiens 91-93 21656370-6 2011 Forskolin-induced increase in TH promoter activity and CRE-dependent transcription are significantly suppressed in alpha-SYN-overexpressing cells. Colforsin 0-9 tyrosine hydroxylase Homo sapiens 30-32 21656370-6 2011 Forskolin-induced increase in TH promoter activity and CRE-dependent transcription are significantly suppressed in alpha-SYN-overexpressing cells. Colforsin 0-9 synuclein alpha Homo sapiens 115-124 21344481-6 2011 Similarly, activation of CREB by the adenylate cyclase agonist forskolin failed to induce EphA2 promoter activation. Colforsin 63-72 cAMP responsive element binding protein 1 Homo sapiens 25-29 21525298-7 2011 Furthermore, basal and forskolin-stimulated cAMP production is reduced 80-90% in the beta3GnT2(-/-) OE. Colforsin 23-32 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Mus musculus 85-94 21384913-1 2011 Cytochalasin B (CB) and forskolin (FSK) inhibit GLUT1-mediated sugar transport in red cells by binding at or close to the GLUT1 endofacial sugar binding site. Colforsin 24-33 solute carrier family 2 member 1 Homo sapiens 48-53 21384913-1 2011 Cytochalasin B (CB) and forskolin (FSK) inhibit GLUT1-mediated sugar transport in red cells by binding at or close to the GLUT1 endofacial sugar binding site. Colforsin 24-33 solute carrier family 2 member 1 Homo sapiens 122-127 21384913-1 2011 Cytochalasin B (CB) and forskolin (FSK) inhibit GLUT1-mediated sugar transport in red cells by binding at or close to the GLUT1 endofacial sugar binding site. Colforsin 35-38 solute carrier family 2 member 1 Homo sapiens 48-53 21384913-1 2011 Cytochalasin B (CB) and forskolin (FSK) inhibit GLUT1-mediated sugar transport in red cells by binding at or close to the GLUT1 endofacial sugar binding site. Colforsin 35-38 solute carrier family 2 member 1 Homo sapiens 122-127 21384913-7 2011 Like CB, FSK competitively inhibits exchange 3-O-methylglucose transport (sugar uptake in cells containing intracellular sugar) but noncompetitively inhibits sugar uptake into cells lacking sugar at 4 C. This refutes the hypothesis that FSK binds at GLUT1 endofacial and exofacial sugar binding sites. Colforsin 9-12 solute carrier family 2 member 1 Homo sapiens 251-256 21296067-6 2011 To examine its function in chemoresistance, RNA interference (RNAi) and forskolin stimulation experiments further demonstrated that ICBP90 and Topo IIalpha were involved in the proliferation of cells that had acquired doxorubicin resistance. Colforsin 72-81 UHRF1 binding protein 1 Homo sapiens 132-138 21455559-5 2011 Quantitative RT-PCR revealed that in fully syncytialized BeWo cells (treated with 50 microM forskolin for 72 h) there was a significant down-regulation of mPRalpha and up-regulation of mPRbeta and of the progesterone membrane component-1 (PGRMC1) when compared with non-syncytialized BeWo cells. Colforsin 92-101 progesterone receptor membrane component 1 Homo sapiens 239-245 21619452-5 2011 MATERIALS AND METHODS: In cell cultures, we investigated the effects of forskolin/3-isobutyl-1-methylxanthine (IBMX) on stimulated p53 of ALL cell lines. Colforsin 72-81 tumor protein p53 Homo sapiens 131-134 21612641-8 2011 In contrast, TGF-beta1 stimulation of FN1-EDA showed similar levels of reduction with the addition of forskolin in all three cell types. Colforsin 102-111 transforming growth factor beta 1 Homo sapiens 13-22 21612641-8 2011 In contrast, TGF-beta1 stimulation of FN1-EDA showed similar levels of reduction with the addition of forskolin in all three cell types. Colforsin 102-111 fibronectin 1 Homo sapiens 38-41 21612641-8 2011 In contrast, TGF-beta1 stimulation of FN1-EDA showed similar levels of reduction with the addition of forskolin in all three cell types. Colforsin 102-111 ectodysplasin A Homo sapiens 42-45 20715173-7 2011 Similarly, adenylate cyclase activator forskolin and cyclic AMP-dependent protein kinase A inhibitor H-89 enhanced and decreased HIF-1alpha protein amount, respectively. Colforsin 39-48 hypoxia inducible factor 1 subunit alpha Homo sapiens 129-139 21562284-8 2011 We found AKAP79/150 to not play a role in the former, but to be necessary for forskolin-induced upregulation of L-current. Colforsin 78-87 A-kinase anchoring protein 5 Rattus norvegicus 9-15 21238583-4 2011 In cotransfectants, beta(1)AR effect on cAMP was predominant; however, blocking beta(1)AR with antagonist resulted in 60% inhibition of forskolin-stimulated cAMP in the presence of hSSTR5 agonists. Colforsin 136-145 adrenoceptor beta 1 Homo sapiens 80-89 21238583-4 2011 In cotransfectants, beta(1)AR effect on cAMP was predominant; however, blocking beta(1)AR with antagonist resulted in 60% inhibition of forskolin-stimulated cAMP in the presence of hSSTR5 agonists. Colforsin 136-145 somatostatin receptor 5 Homo sapiens 181-187 21312243-10 2011 The inhibition of CaMKK isoforms, particularly CaMKKbeta, by the inhibitor STO-609 or by siRNAs, blocked Ca(2+) -, but not phenformin-, AICAR-, or forskolin-induced activation of AMPK, indicating that CaMKK activated AMPK in response to Ca(2+) . Colforsin 147-156 calcium/calmodulin-dependent protein kinase kinase 1, alpha Mus musculus 18-23 21312243-10 2011 The inhibition of CaMKK isoforms, particularly CaMKKbeta, by the inhibitor STO-609 or by siRNAs, blocked Ca(2+) -, but not phenformin-, AICAR-, or forskolin-induced activation of AMPK, indicating that CaMKK activated AMPK in response to Ca(2+) . Colforsin 147-156 calcium/calmodulin-dependent protein kinase kinase 2, beta Mus musculus 47-56 21335064-9 2011 Moreover, electrical stimulation and forskolin, known to increase intracellular cAMP, potentiate the TNFalpha-mediated upregulation of BDNF expression. Colforsin 37-46 tumor necrosis factor Rattus norvegicus 101-109 21335064-9 2011 Moreover, electrical stimulation and forskolin, known to increase intracellular cAMP, potentiate the TNFalpha-mediated upregulation of BDNF expression. Colforsin 37-46 brain-derived neurotrophic factor Rattus norvegicus 135-139 21216955-7 2011 CaV1.2 channels in DCT-/- myocytes fail to respond to activation of adenylyl cyclase by forskolin, and the localized expression of AKAP15 is reduced. Colforsin 88-97 calcium channel, voltage-dependent, L type, alpha 1C subunit Mus musculus 0-6 21490976-7 2011 Brief treatment of mixed neuronal/glial POA cultures with PGE2 or the cAMP/PKA stimulator, forskolin, increased membrane associated GluR1 in both neurons and glia. Colforsin 91-100 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 132-137 21233840-0 2011 PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. Colforsin 89-98 protein phosphatase 2 phosphatase activator Homo sapiens 0-4 21228062-4 2011 Forskolin-stimulated AC activity in membranes from hBSMC displayed Ca(2+)-inhibited and G(betagamma)-stimulated AC activity, consistent with expression of AC6, AC2, and AC4. Colforsin 0-9 adenylate cyclase 6 Homo sapiens 155-158 21228062-4 2011 Forskolin-stimulated AC activity in membranes from hBSMC displayed Ca(2+)-inhibited and G(betagamma)-stimulated AC activity, consistent with expression of AC6, AC2, and AC4. Colforsin 0-9 adenylate cyclase 2 Homo sapiens 160-163 21228062-4 2011 Forskolin-stimulated AC activity in membranes from hBSMC displayed Ca(2+)-inhibited and G(betagamma)-stimulated AC activity, consistent with expression of AC6, AC2, and AC4. Colforsin 0-9 adenylate cyclase 4 Homo sapiens 169-172 21233840-3 2011 Here, we show that PP2A inactivation is a recurrent event in acute myeloid leukemia (AML), and that restoration of PP2A phosphatase activity by treatment with forskolin in AML cells blocks proliferation, induces caspase-dependent apoptosis and affects AKT and ERK1/2 activity. Colforsin 159-168 protein phosphatase 2 phosphatase activator Homo sapiens 19-23 21233840-3 2011 Here, we show that PP2A inactivation is a recurrent event in acute myeloid leukemia (AML), and that restoration of PP2A phosphatase activity by treatment with forskolin in AML cells blocks proliferation, induces caspase-dependent apoptosis and affects AKT and ERK1/2 activity. Colforsin 159-168 protein phosphatase 2 phosphatase activator Homo sapiens 115-119 21233840-3 2011 Here, we show that PP2A inactivation is a recurrent event in acute myeloid leukemia (AML), and that restoration of PP2A phosphatase activity by treatment with forskolin in AML cells blocks proliferation, induces caspase-dependent apoptosis and affects AKT and ERK1/2 activity. Colforsin 159-168 AKT serine/threonine kinase 1 Homo sapiens 252-255 21233840-3 2011 Here, we show that PP2A inactivation is a recurrent event in acute myeloid leukemia (AML), and that restoration of PP2A phosphatase activity by treatment with forskolin in AML cells blocks proliferation, induces caspase-dependent apoptosis and affects AKT and ERK1/2 activity. Colforsin 159-168 mitogen-activated protein kinase 3 Homo sapiens 260-266 21233840-7 2011 In conclusion, our results show that PP2A inhibition is a common event in AML cells and that PP2A activators, such as forskolin or FTY720, could represent potential novel therapeutic targets in AML. Colforsin 118-127 protein phosphatase 2 phosphatase activator Homo sapiens 93-97 21071747-3 2011 METHODS: Forskolin (Fsk) and rolipram were used to elevate cAMP levels. Colforsin 9-18 cathelicidin-7 Bos taurus 59-63 21251947-10 2011 In addition, the reduction in transcriptional activity of forskolin-stimulated PTGS2 promoter by BF, indicates that BF blocks the expression of PTGS2 gene at the transcriptional level. Colforsin 58-67 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 79-84 21251947-10 2011 In addition, the reduction in transcriptional activity of forskolin-stimulated PTGS2 promoter by BF, indicates that BF blocks the expression of PTGS2 gene at the transcriptional level. Colforsin 58-67 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 144-149 21251947-9 2011 Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway. Colforsin 0-9 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 21-26 21251947-9 2011 Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway. Colforsin 0-9 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 116-121 21251947-9 2011 Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 145-161 21251947-9 2011 Forskolin stimulated PTGS2 expression was decreased by treatment with BF, indicating that BF may inhibit LH-induced PTGS2 expression through the protein kinase A (PKA)-mediated signaling pathway. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 163-166 21071747-3 2011 METHODS: Forskolin (Fsk) and rolipram were used to elevate cAMP levels. Colforsin 20-23 cathelicidin-7 Bos taurus 59-63 21148409-5 2011 Forskolin-induced changes in pS261 were also observed for AQP2-S256A and AQP2-S256D, which constitutively localize in vesicles and the apical membrane, respectively. Colforsin 0-9 aquaporin 2 Canis lupus familiaris 58-62 21291865-5 2011 Since A1 receptor activation is mainly coupled to inhibitory G-proteins and inhibits the activity of adenylate cyclase, we investigated the effect of forskolin, which activates adenylate cyclase activity, on EAAT2 mRNA levels. Colforsin 150-159 solute carrier family 1 member 2 Homo sapiens 208-213 21291865-6 2011 Interestingly, we found that forskolin reduced EAAT2 expression in dose- and time-dependent manners. Colforsin 29-38 solute carrier family 1 member 2 Homo sapiens 47-52 21291865-8 2011 In addition, forskolin blocked ethanol-induced EAAT2 upregulation. Colforsin 13-22 solute carrier family 1 member 2 Homo sapiens 47-52 21131397-5 2011 cAMP and airway relaxation in response to direct activation of AC by forskolin were increased in AC5-TG. Colforsin 69-78 adenylate cyclase 5 Mus musculus 63-65 21131397-5 2011 cAMP and airway relaxation in response to direct activation of AC by forskolin were increased in AC5-TG. Colforsin 69-78 adenylate cyclase 5 Mus musculus 97-100 21148409-3 2011 Forskolin stimulation associated with increased pS256 and decreased pS261 AQP2, indicating that MDCK cells are a good model. Colforsin 0-9 aquaporin 2 Canis lupus familiaris 74-78 21148409-5 2011 Forskolin-induced changes in pS261 were also observed for AQP2-S256A and AQP2-S256D, which constitutively localize in vesicles and the apical membrane, respectively. Colforsin 0-9 aquaporin 2 Canis lupus familiaris 73-77 21115086-6 2011 Therefore, as measured immunochemically and by [(3)H]-forskolin binding, there seems to be a vast excess of Gsalpha subunits over catalytic units of AC. Colforsin 54-63 GNAS complex locus Homo sapiens 108-115 21094673-6 2011 Forskolin-stimulated R28 cells displayed a robust cholinergic response, as detected by both electrophysiology and ChE expression, and changed the activation status of PKC/ERK signaling pathways. Colforsin 0-9 butyrylcholinesterase Rattus norvegicus 114-117 21094673-6 2011 Forskolin-stimulated R28 cells displayed a robust cholinergic response, as detected by both electrophysiology and ChE expression, and changed the activation status of PKC/ERK signaling pathways. Colforsin 0-9 Eph receptor B1 Rattus norvegicus 171-174 21187084-11 2011 Furthermore, curcumin reduced the intracellular signaling proteins Ras, B-raf, p-MEK, p-ERK, c-fos, Egr-1, but increased Raf-1 and NAB2 in MDCK cells exposed to forskolin. Colforsin 161-170 B-Raf proto-oncogene, serine/threonine kinase Canis lupus familiaris 72-77 21187084-11 2011 Furthermore, curcumin reduced the intracellular signaling proteins Ras, B-raf, p-MEK, p-ERK, c-fos, Egr-1, but increased Raf-1 and NAB2 in MDCK cells exposed to forskolin. Colforsin 161-170 Raf-1 proto-oncogene, serine/threonine kinase Canis lupus familiaris 121-126 21075212-10 2011 Moreover, we have also found forskolin, PKA activator, could enhance open chromatin accessibility, by which to expose the CRE and facilitate phosphorylation of CREB, which in turn recruits co-factor CBP and Brg I and then results in a more open chromatin configuration associated with local histone modification, finally heightening RAB25 expression and strengthening its promoter activity. Colforsin 29-38 cAMP responsive element binding protein 1 Homo sapiens 160-164 21075212-10 2011 Moreover, we have also found forskolin, PKA activator, could enhance open chromatin accessibility, by which to expose the CRE and facilitate phosphorylation of CREB, which in turn recruits co-factor CBP and Brg I and then results in a more open chromatin configuration associated with local histone modification, finally heightening RAB25 expression and strengthening its promoter activity. Colforsin 29-38 CREB binding protein Homo sapiens 199-202 21075212-10 2011 Moreover, we have also found forskolin, PKA activator, could enhance open chromatin accessibility, by which to expose the CRE and facilitate phosphorylation of CREB, which in turn recruits co-factor CBP and Brg I and then results in a more open chromatin configuration associated with local histone modification, finally heightening RAB25 expression and strengthening its promoter activity. Colforsin 29-38 RAB25, member RAS oncogene family Homo sapiens 333-338 21084060-3 2011 The very high-affinity Atp7b copper pump presented here shows a K(0.5) for free copper of 2.5x10(-17) M in bathocuproine disulfonate/copper buffer and ATP hydrolysis was inhibited 50% upon stimulation of PKA pathway, using forskolin, cAMP or cholera toxin. Colforsin 223-232 ATPase copper transporting beta Homo sapiens 23-28 21113728-9 2011 Increase of extracellular K+ concentrations to 35 mM (replacing Na+/NMDG) or treatment with 5 muM forskolin increased pH/min in sgk3+/+ mice to a larger extent than in sgk3-/- mice and abrogated the differences between genotypes. Colforsin 98-107 serum/glucocorticoid regulated kinase 3 Mus musculus 129-133 21113728-9 2011 Increase of extracellular K+ concentrations to 35 mM (replacing Na+/NMDG) or treatment with 5 muM forskolin increased pH/min in sgk3+/+ mice to a larger extent than in sgk3-/- mice and abrogated the differences between genotypes. Colforsin 98-107 serum/glucocorticoid regulated kinase 3 Mus musculus 169-173 21488208-4 2011 RESULT: Forskolin (10 mumol/L) induced morphological changes and GFAP protein expression (cell differentiation) in C6 cells, but LTD(4) (0.1-100 nmol/L) did not induce these changes. Colforsin 8-17 glial fibrillary acidic protein Rattus norvegicus 65-69 21177856-10 2011 In human aortic endothelial cells (HAEC), pretreatment with H89 (PKA inhibitor) or siRNA knockdown of PKA-alpha decreased forskolin- or prostaglandin E(2)-stimulated phosphorylation of FoxO1. Colforsin 122-131 forkhead box O1 Homo sapiens 185-190 21097823-7 2011 This catecholamine-mediated increase in FSP27 abundance, probably a feedback mechanism for restraining excessive lipolysis by catecholamines, is mimicked by forskolin or 8-bromo-cAMP treatment and is prevented by the protein kinase A (PKA) inhibitor KT5720 or by PKA depletion using siRNA. Colforsin 157-166 cell death-inducing DFFA-like effector c Mus musculus 40-45 21135203-3 2011 A DNA microarray analysis of BeWo cells undergoing forskolin-induced syncytialization revealed that among the induced genes, placental growth factor (PlGF) was 10-fold upregulated. Colforsin 51-60 placental growth factor Homo sapiens 125-148 21135203-3 2011 A DNA microarray analysis of BeWo cells undergoing forskolin-induced syncytialization revealed that among the induced genes, placental growth factor (PlGF) was 10-fold upregulated. Colforsin 51-60 placental growth factor Homo sapiens 150-154 21225244-7 2011 A 5-min treatment with NAD decreased forskolin-stimulated phosphorylation at the beta(2)AR PKA site Ser 262 while a 24-h treatment with NAD increased it. Colforsin 37-46 adrenoceptor beta 2 Homo sapiens 81-90 20970474-9 2011 BMP-4 treatment enhanced the reducing effect of SOM230 on forskolin-induced PRL level while BMP-4 did not affect the effects of OCT or BRC. Colforsin 58-67 bone morphogenetic protein 4 Rattus norvegicus 0-5 21035520-4 2011 Forskolin treatment induced a rapid and potent ERK1/2 and p38MAPK phosphorylation; this cascade required PKA-AKAP interactions and led to downstream CREB-1/ATF-1 phosphorylation via ERK1/2-dependent but p38MAPK-independent mechanisms. Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 149-155 21035520-4 2011 Forskolin treatment induced a rapid and potent ERK1/2 and p38MAPK phosphorylation; this cascade required PKA-AKAP interactions and led to downstream CREB-1/ATF-1 phosphorylation via ERK1/2-dependent but p38MAPK-independent mechanisms. Colforsin 0-9 activating transcription factor 1 Homo sapiens 156-161 20970474-7 2011 In GH3 cells activated by forskolin, BRC suppressed forskolin-induced PRL secretion with reduction in cAMP levels. Colforsin 26-35 prolactin Rattus norvegicus 70-73 20970474-7 2011 In GH3 cells activated by forskolin, BRC suppressed forskolin-induced PRL secretion with reduction in cAMP levels. Colforsin 52-61 prolactin Rattus norvegicus 70-73 21035520-4 2011 Forskolin treatment induced a rapid and potent ERK1/2 and p38MAPK phosphorylation; this cascade required PKA-AKAP interactions and led to downstream CREB-1/ATF-1 phosphorylation via ERK1/2-dependent but p38MAPK-independent mechanisms. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 182-188 20970474-9 2011 BMP-4 treatment enhanced the reducing effect of SOM230 on forskolin-induced PRL level while BMP-4 did not affect the effects of OCT or BRC. Colforsin 58-67 prolactin Rattus norvegicus 76-79 21035520-5 2011 Interestingly both p38MAPK and ERK1/2 were involved in forskolin-induced hCG-secretion, suggesting the presence of additional p38MAPK-dependent but CREB-1/ATF-1-independent pathways. Colforsin 55-64 mitogen-activated protein kinase 3 Homo sapiens 31-37 21035520-5 2011 Interestingly both p38MAPK and ERK1/2 were involved in forskolin-induced hCG-secretion, suggesting the presence of additional p38MAPK-dependent but CREB-1/ATF-1-independent pathways. Colforsin 55-64 chorionic gonadotropin subunit beta 5 Homo sapiens 73-76 21035520-5 2011 Interestingly both p38MAPK and ERK1/2 were involved in forskolin-induced hCG-secretion, suggesting the presence of additional p38MAPK-dependent but CREB-1/ATF-1-independent pathways. Colforsin 55-64 cAMP responsive element binding protein 1 Homo sapiens 148-154 21035520-5 2011 Interestingly both p38MAPK and ERK1/2 were involved in forskolin-induced hCG-secretion, suggesting the presence of additional p38MAPK-dependent but CREB-1/ATF-1-independent pathways. Colforsin 55-64 activating transcription factor 1 Homo sapiens 155-160 21035520-6 2011 Forskolin treatment of BeWo cells significantly up-regulated the expression of various fusogenic gene mRNAs, including syncytin-1 and -2 (by 3- and 10-fold, respectively) the transcription factors old astrocyte specifically induced substance (OASIS) and glial cells missing a (GCMa) (by 3- and 6-fold, respectively) and the syncytin-2 receptor, major facilitator superfamily domain containing 2 (MFSD2) (by 2-fold). Colforsin 0-9 endogenous retrovirus group W member 1, envelope Homo sapiens 119-136 21035520-6 2011 Forskolin treatment of BeWo cells significantly up-regulated the expression of various fusogenic gene mRNAs, including syncytin-1 and -2 (by 3- and 10-fold, respectively) the transcription factors old astrocyte specifically induced substance (OASIS) and glial cells missing a (GCMa) (by 3- and 6-fold, respectively) and the syncytin-2 receptor, major facilitator superfamily domain containing 2 (MFSD2) (by 2-fold). Colforsin 0-9 cAMP responsive element binding protein 3 like 1 Homo sapiens 197-241 21035520-6 2011 Forskolin treatment of BeWo cells significantly up-regulated the expression of various fusogenic gene mRNAs, including syncytin-1 and -2 (by 3- and 10-fold, respectively) the transcription factors old astrocyte specifically induced substance (OASIS) and glial cells missing a (GCMa) (by 3- and 6-fold, respectively) and the syncytin-2 receptor, major facilitator superfamily domain containing 2 (MFSD2) (by 2-fold). Colforsin 0-9 cAMP responsive element binding protein 3 like 1 Homo sapiens 243-248 20970474-11 2011 However, in the presence of Noggin, OCT elicited an inhibitory effect on forskolin-induced PRL secretion and PRL mRNA expression, whereas the SOM230 effect on PRL reduction was in turn impaired. Colforsin 73-82 noggin Rattus norvegicus 28-34 21035520-6 2011 Forskolin treatment of BeWo cells significantly up-regulated the expression of various fusogenic gene mRNAs, including syncytin-1 and -2 (by 3- and 10-fold, respectively) the transcription factors old astrocyte specifically induced substance (OASIS) and glial cells missing a (GCMa) (by 3- and 6-fold, respectively) and the syncytin-2 receptor, major facilitator superfamily domain containing 2 (MFSD2) (by 2-fold). Colforsin 0-9 major facilitator superfamily domain containing 2A Homo sapiens 345-394 21035520-6 2011 Forskolin treatment of BeWo cells significantly up-regulated the expression of various fusogenic gene mRNAs, including syncytin-1 and -2 (by 3- and 10-fold, respectively) the transcription factors old astrocyte specifically induced substance (OASIS) and glial cells missing a (GCMa) (by 3- and 6-fold, respectively) and the syncytin-2 receptor, major facilitator superfamily domain containing 2 (MFSD2) (by 2-fold). Colforsin 0-9 major facilitator superfamily domain containing 2A Homo sapiens 396-401 21035520-7 2011 Up-regulation of AKAP79 and AKAP250 (by 2.5- and 4-fold, respectively) was also identified in forskolin-treated BeWo cells. Colforsin 94-103 A-kinase anchoring protein 5 Homo sapiens 17-23 21035520-7 2011 Up-regulation of AKAP79 and AKAP250 (by 2.5- and 4-fold, respectively) was also identified in forskolin-treated BeWo cells. Colforsin 94-103 A-kinase anchoring protein 12 Homo sapiens 28-35 20970474-11 2011 However, in the presence of Noggin, OCT elicited an inhibitory effect on forskolin-induced PRL secretion and PRL mRNA expression, whereas the SOM230 effect on PRL reduction was in turn impaired. Colforsin 73-82 prolactin Rattus norvegicus 91-94 21035520-8 2011 Forskolin effects on all these genes were suppressed by chemical inhibition of p38MAPK whereas only specific genes were sensitive to ERK1/2 inhibition. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 133-139 21035520-4 2011 Forskolin treatment induced a rapid and potent ERK1/2 and p38MAPK phosphorylation; this cascade required PKA-AKAP interactions and led to downstream CREB-1/ATF-1 phosphorylation via ERK1/2-dependent but p38MAPK-independent mechanisms. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 47-53 21035520-4 2011 Forskolin treatment induced a rapid and potent ERK1/2 and p38MAPK phosphorylation; this cascade required PKA-AKAP interactions and led to downstream CREB-1/ATF-1 phosphorylation via ERK1/2-dependent but p38MAPK-independent mechanisms. Colforsin 0-9 A-kinase anchoring protein 1 Homo sapiens 109-113 21081692-4 2011 It was found that stimulation of the PKA pathway by the adenylyl cyclase activator, forskolin, caused a twofold increase in LIPE transcript accompanied by appreciable rise in the protein product of the gene and cortisol output. Colforsin 84-93 lipase E, hormone sensitive type Homo sapiens 124-128 21097507-7 2011 Moreover, PGE(2) and the cAMP analog forskolin could mimic tumor-mediated CCL5 inhibition, and the inhibitory effects of TCM, PGE(2), and cAMP analog on LPS-induced CCL5 expression could be completely reversed by the PKA inhibitor H89. Colforsin 37-46 chemokine (C-C motif) ligand 5 Mus musculus 74-78 21081692-6 2011 Forskolin and PKA catalytic subunit increased transcriptional activity of LIPE promoter A in cells transfected with the luciferase reporter vector. Colforsin 0-9 lipase E, hormone sensitive type Homo sapiens 74-78 21081692-7 2011 Overexpression of steroidogenic factor-1 (SF-1) increased LIPE promoter activity, while transient silencing of SF-1 expression with specific siRNAs abolished forskolin-stimulated LIPE transcription. Colforsin 158-167 lipase E, hormone sensitive type Homo sapiens 179-183 20977910-9 2011 Using a pGL3-CRE luciferase reporter system, chicken galanin peptide (1-29) was demonstrated to inhibit both basal and forskolin-stimulated luciferase activities, in dose-dependent manners, through the cAMP-mediated signaling pathway in Chinese hamster ovary (CHO) cells expressing either cGalR1 or cGalR1-L, thus suggesting the functional couplings of both receptors to G(i) proteins. Colforsin 119-128 galanin and GMAP prepropeptide Gallus gallus 53-60 20959116-7 2011 The response of male Irs-2(-/-) islets to forskolin was enhanced, owing to increased production of cAMP. Colforsin 42-51 insulin receptor substrate 2 Mus musculus 21-26 20965237-4 2011 In human prostate cancer DU145 cells, FSK (1 muM) and FGF2 (10 ng/ml) increased BSP and Runx2 mRNA and protein levels at 3 and 12h, respectively. Colforsin 38-41 integrin binding sialoprotein Homo sapiens 80-83 20965237-4 2011 In human prostate cancer DU145 cells, FSK (1 muM) and FGF2 (10 ng/ml) increased BSP and Runx2 mRNA and protein levels at 3 and 12h, respectively. Colforsin 38-41 RUNX family transcription factor 2 Homo sapiens 88-93 20965237-6 2011 Treatment of DU145 cells with FSK (1 muM) and FGF2 (10 ng/ml) increased the luciferase activities of constructs between -60LUC to -927LUC and -108LUC to -927LUC, including the human BSP gene promoter. Colforsin 30-33 integrin binding sialoprotein Homo sapiens 182-185 20965237-12 2011 These studies demonstrate that FSK and FGF2 stimulate BSP transcription in DU145 human prostate cancer cells by targeting the CRE1 and CRE2 elements in the human BSP gene promoter. Colforsin 31-34 integrin binding sialoprotein Homo sapiens 54-57 20965237-12 2011 These studies demonstrate that FSK and FGF2 stimulate BSP transcription in DU145 human prostate cancer cells by targeting the CRE1 and CRE2 elements in the human BSP gene promoter. Colforsin 31-34 integrin binding sialoprotein Homo sapiens 162-165 21865731-4 2011 The forskolin-stimulated (10 muM) I(sc) was significantly inhibited by the CFTR chloride channel inhibitors, glibenclamide (500 muM) and CFTR(inh)-172 (100 muM) in 600G males and females, suggesting some contribution by genistein-dependent CFTR-mediated Cl(-) secretion. Colforsin 4-13 cystic fibrosis transmembrane conductance regulator Mus musculus 75-79 22116356-4 2011 RESULTS: After exposure to forskolin, the membrane abundance of wild type pendrin and iodide efflux increase. Colforsin 27-36 solute carrier family 26 member 4 Homo sapiens 74-81 22178870-8 2011 In addition, in CPVT1-cardiomyocytes the Ca(2+)-induced Ca(2+)-release events continued after repolarization and were abolished by increasing the cytosolic cAMP levels with forskolin. Colforsin 173-182 cathelicidin antimicrobial peptide Homo sapiens 156-160 21865731-4 2011 The forskolin-stimulated (10 muM) I(sc) was significantly inhibited by the CFTR chloride channel inhibitors, glibenclamide (500 muM) and CFTR(inh)-172 (100 muM) in 600G males and females, suggesting some contribution by genistein-dependent CFTR-mediated Cl(-) secretion. Colforsin 4-13 cystic fibrosis transmembrane conductance regulator Mus musculus 137-141 22178883-6 2011 In HEK293 cells coexpressing TMEM16A and CFTR, whole cell currents activated by IMBX and forskolin were significantly reduced when compared with cells expressing CFTR only, while the halide permeability sequence of CFTR was not changed. Colforsin 89-98 anoctamin 1 Homo sapiens 29-36 22178883-6 2011 In HEK293 cells coexpressing TMEM16A and CFTR, whole cell currents activated by IMBX and forskolin were significantly reduced when compared with cells expressing CFTR only, while the halide permeability sequence of CFTR was not changed. Colforsin 89-98 CF transmembrane conductance regulator Homo sapiens 41-45 22178883-8 2011 TMEM16A-currents were attenuated by additional expression of CFTR, and were completely abrogated when additionally expressed CFTR was activated by IBMX and forskolin. Colforsin 156-165 CF transmembrane conductance regulator Homo sapiens 125-129 22178883-6 2011 In HEK293 cells coexpressing TMEM16A and CFTR, whole cell currents activated by IMBX and forskolin were significantly reduced when compared with cells expressing CFTR only, while the halide permeability sequence of CFTR was not changed. Colforsin 89-98 CF transmembrane conductance regulator Homo sapiens 162-166 21865731-4 2011 The forskolin-stimulated (10 muM) I(sc) was significantly inhibited by the CFTR chloride channel inhibitors, glibenclamide (500 muM) and CFTR(inh)-172 (100 muM) in 600G males and females, suggesting some contribution by genistein-dependent CFTR-mediated Cl(-) secretion. Colforsin 4-13 cystic fibrosis transmembrane conductance regulator Mus musculus 137-141 22178883-6 2011 In HEK293 cells coexpressing TMEM16A and CFTR, whole cell currents activated by IMBX and forskolin were significantly reduced when compared with cells expressing CFTR only, while the halide permeability sequence of CFTR was not changed. Colforsin 89-98 CF transmembrane conductance regulator Homo sapiens 162-166 22178883-8 2011 TMEM16A-currents were attenuated by additional expression of CFTR, and were completely abrogated when additionally expressed CFTR was activated by IBMX and forskolin. Colforsin 156-165 anoctamin 1 Homo sapiens 0-7 21865666-5 2011 Basal production of cyclic adenosine monophosphate (cAMP) was not affected, but responses to GTPgammaS, isoprenaline, noradrenaline, SKF 38393 and forskolin were depressed in the Ts65Dn hippocampus. Colforsin 147-156 reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65 Mus musculus 179-185 21079388-9 2011 Forskolin increased SSTR1, SSTR2, DR1 and DR2 expression in cell cultures. Colforsin 0-9 somatostatin receptor 1 Homo sapiens 20-25 21646788-6 2011 Immunomodulators such as lipopolysaccharides/forskolin/curdlan change the nature of DCs to induce Th1/Th2/Th17 cells thereby designated Th1/Th2/Th17 adjuvants. Colforsin 45-54 negative elongation factor complex member C/D Homo sapiens 98-101 21646788-6 2011 Immunomodulators such as lipopolysaccharides/forskolin/curdlan change the nature of DCs to induce Th1/Th2/Th17 cells thereby designated Th1/Th2/Th17 adjuvants. Colforsin 45-54 negative elongation factor complex member C/D Homo sapiens 106-109 20658517-6 2011 However, the forskolin (FK)-stimulated currents were enhanced in SLC26A9-transduced cells compared to control cells. Colforsin 13-22 solute carrier family 26 member 9 Homo sapiens 65-72 21047926-10 2011 The simultaneous inactivation of PRKAR1A and PDE11A by small inhibitory RNA led to an increase in cAMP-regulatory element-mediated transcriptional activity under basal conditions and after stimulation by forskolin. Colforsin 204-213 protein kinase cAMP-dependent type I regulatory subunit alpha Homo sapiens 33-40 21047926-10 2011 The simultaneous inactivation of PRKAR1A and PDE11A by small inhibitory RNA led to an increase in cAMP-regulatory element-mediated transcriptional activity under basal conditions and after stimulation by forskolin. Colforsin 204-213 phosphodiesterase 11A Homo sapiens 45-51 21461565-10 2011 The cAMP level, which was increased by forskolin and pertussis toxin, was decreased by fibronectin. Colforsin 39-48 fibronectin 1 Homo sapiens 87-98 21461565-11 2011 The nuclear location of the PKA catalytic unit, the phosphorylation of VASP and cAMP response element (CRE)-directed reporter gene expression induced by forskolin were blocked by fibronectin. Colforsin 153-162 vasodilator stimulated phosphoprotein Homo sapiens 71-75 21461565-11 2011 The nuclear location of the PKA catalytic unit, the phosphorylation of VASP and cAMP response element (CRE)-directed reporter gene expression induced by forskolin were blocked by fibronectin. Colforsin 153-162 fibronectin 1 Homo sapiens 179-190 21391093-6 2011 TBT, when given alone and also in combination with forskolin, decreased IL-1beta, TNFalpha, IFNgamma, IFNalpha, Mx3, and IGF-1 gene expression. Colforsin 51-60 tnf-alpha Salmo salar 82-90 21391093-7 2011 In contrast, IL-10 and TGFbeta transcripts were increased after TBT exposure alone and also in combination with forskolin. Colforsin 112-121 interleukin-10 Salmo salar 13-18 21391093-7 2011 In contrast, IL-10 and TGFbeta transcripts were increased after TBT exposure alone and also in combination with forskolin. Colforsin 112-121 transforming growth factor beta-1 proprotein Salmo salar 23-30 21084381-6 2011 ERK activation was comparable for wild-type and mutant MC1R and was independent on cAMP because it was neither triggered by stimulation of cAMP synthesis with forskolin nor blocked by the adenylyl cyclase inhibitor 2",5"-dideoxyadenosine. Colforsin 159-168 mitogen-activated protein kinase 1 Homo sapiens 0-3 21079388-9 2011 Forskolin increased SSTR1, SSTR2, DR1 and DR2 expression in cell cultures. Colforsin 0-9 somatostatin receptor 2 Homo sapiens 27-32 21079388-9 2011 Forskolin increased SSTR1, SSTR2, DR1 and DR2 expression in cell cultures. Colforsin 0-9 down-regulator of transcription 1 Homo sapiens 34-37 22007271-7 2011 Similar results were observed when investigating the effects of CoCl(2)-induced ROS on the neural stimulation of PNMT via forskolin. Colforsin 122-131 phenylethanolamine-N-methyltransferase Rattus norvegicus 113-117 21876762-10 2011 TC48 expression inhibited forskolin induced tyrosine phosphorylation of C3G and neurite outgrowth in IMR-32 cells. Colforsin 26-35 Rap guanine nucleotide exchange factor 1 Homo sapiens 72-75 20971192-9 2011 TSP1 inhibited both forskolin and isoproterenol stimulated increases in cAMP in VSMCs. Colforsin 20-29 thrombospondin 1 Mus musculus 0-4 20971192-10 2011 TSP1 also abrogated forskolin and isoproterenol stimulated vasodilation. Colforsin 20-29 thrombospondin 1 Mus musculus 0-4 21857082-2 2011 Orexin A, an agonist of OX1 and OX2 receptors, stimulated cAMP production with an EC50 value of 0.68 muM and potentiated the forskolin-induced increase in the nucleotide synthesis. Colforsin 125-134 hypocretin neuropeptide precursor Rattus norvegicus 0-8 21426859-7 2011 Melatonin inhibited both the eCG- and forskolin-stimulated production of progesterone, as well as the forskolin-stimulated expression of P450scc, in equine luteal cells and the effect was dose-dependent. Colforsin 102-111 cytochrome P450 family 11 subfamily A member 1 Equus caballus 137-144 21611147-7 2011 However when PDE4 was specifically inhibited, cAMP production by the agonists and forskolin was normalized in asthmatic ASM. Colforsin 82-91 phosphodiesterase 4A Homo sapiens 13-17 20458731-2 2010 Here, we show that stimulating mitogenesis of Swiss 3T3 cells with phorbol esters or forskolin can induce divergent responses in the expression levels, localization and activation state of cyclin D1 and cyclin D3. Colforsin 85-94 cyclin D1 Mus musculus 189-198 20962002-6 2010 Forskolin-induced NHE3 inhibition was preserved in the absence of NHERF2, whereas Ca2+ ionophore- or carbachol-mediated inhibition was abolished. Colforsin 0-9 solute carrier family 9 (sodium/hydrogen exchanger), member 3 Mus musculus 18-22 20861470-7 2010 PKA activation with forskolin (20 muM) restored NKA Na(+) affinity in cells expressing WT but not AA PLM and did not affect V(max) in either case. Colforsin 20-29 tachykinin precursor 1 Homo sapiens 48-51 20728450-7 2010 Isolated akt2(-/-) hearts were hypersensitive to isoproterenol (ISO) but exhibited normal sensitivity to forskolin. Colforsin 105-114 thymoma viral proto-oncogene 2 Mus musculus 9-13 20861310-6 2010 CNN3 at the cytoplasmic face of cytoskeleton was dislocated from F-actin with forskolin treatment and diffused into the cytoplasm in a phosphorylation-dependent manner. Colforsin 78-87 calponin 3 Homo sapiens 0-4 20861310-8 2010 These CNN3 mutants were colocalized with F-actin and remained there after forskolin treatment, suggesting that dissociation of CNN3 from F-actin is modulated by the phosphorylation status of the C-terminal region unique to CNN3 in the CNN family proteins. Colforsin 74-83 calponin 3 Homo sapiens 6-10 20861310-8 2010 These CNN3 mutants were colocalized with F-actin and remained there after forskolin treatment, suggesting that dissociation of CNN3 from F-actin is modulated by the phosphorylation status of the C-terminal region unique to CNN3 in the CNN family proteins. Colforsin 74-83 calponin 3 Homo sapiens 127-131 20861310-8 2010 These CNN3 mutants were colocalized with F-actin and remained there after forskolin treatment, suggesting that dissociation of CNN3 from F-actin is modulated by the phosphorylation status of the C-terminal region unique to CNN3 in the CNN family proteins. Colforsin 74-83 calponin 3 Homo sapiens 127-131 20728507-5 2010 Administration of forskolin, an activator for adenylate cyclase/protein kinase A (PKA), but not TPA, an activator for protein kinase C (PKC), induced Pdyn mRNA expression, suggesting a major role for PKA. Colforsin 18-27 prodynorphin Rattus norvegicus 150-154 20844005-10 2010 PANDER treatment also resulted in higher levels of Ser133-phosphorylated cAMP-response element-binding protein in hepatocytes stimulated with 8-bromo-cAMP and dexamethasone and higher levels of intracellular cAMP upon stimulation with forskolin. Colforsin 235-244 FAM3 metabolism regulating signaling molecule B Mus musculus 0-6 21143927-11 2010 Gli1 gene expression was significantly reduced by SANT-1, PACAP and forskolin, but was unaffected by purmorphamine. Colforsin 68-77 GLI-Kruppel family member GLI1 Mus musculus 0-4 21037102-4 2010 Furthermore, elevation of cellular cAMP levels by forskolin/rolipram or beta receptor agonist isoproterenol blocked loss of intercellular adhesion, depletion of cellular Dsg3, and morphologic changes induced by Ab fractions of PV patients (PV-IgG) in cultured keratinocytes. Colforsin 50-59 desmoglein 3 Mus musculus 170-174 20943996-8 2010 Finally, in mPGES-1(-/-) chondrocytes treated by forskolin, MMP-3 protein expression was significantly decreased compared with wild-type, suggesting that PGE(2) regulates MMP-3 expression via a signaling pathway dependent on cAMP. Colforsin 49-58 prostaglandin E synthase Mus musculus 12-19 20943996-8 2010 Finally, in mPGES-1(-/-) chondrocytes treated by forskolin, MMP-3 protein expression was significantly decreased compared with wild-type, suggesting that PGE(2) regulates MMP-3 expression via a signaling pathway dependent on cAMP. Colforsin 49-58 matrix metallopeptidase 3 Mus musculus 60-65 20943996-8 2010 Finally, in mPGES-1(-/-) chondrocytes treated by forskolin, MMP-3 protein expression was significantly decreased compared with wild-type, suggesting that PGE(2) regulates MMP-3 expression via a signaling pathway dependent on cAMP. Colforsin 49-58 matrix metallopeptidase 3 Mus musculus 171-176 20589829-4 2010 Interestingly, intracellular cAMP elevation upon forskolin pretreatment completely abrogated both ERK1/2 and STAT3 phosphorylation in response to leptin and was accompanied by a consistent CREB phosphorylation. Colforsin 49-58 mitogen-activated protein kinase 3 Homo sapiens 98-104 20589829-4 2010 Interestingly, intracellular cAMP elevation upon forskolin pretreatment completely abrogated both ERK1/2 and STAT3 phosphorylation in response to leptin and was accompanied by a consistent CREB phosphorylation. Colforsin 49-58 signal transducer and activator of transcription 3 Homo sapiens 109-114 20589829-4 2010 Interestingly, intracellular cAMP elevation upon forskolin pretreatment completely abrogated both ERK1/2 and STAT3 phosphorylation in response to leptin and was accompanied by a consistent CREB phosphorylation. Colforsin 49-58 cAMP responsive element binding protein 1 Homo sapiens 189-193 20589829-6 2010 Importantly, pretreatment with the PKA inhibitor KT-5720 blocked the forskolin-induced CREB phosphorylation and prevented both the inhibition by forskolin of leptin-induced ERK1/2 and STAT3 phosphorylation and the PKA subunits down-regulation induced by the combination of leptin and forskolin. Colforsin 69-78 cAMP responsive element binding protein 1 Homo sapiens 87-91 20589829-6 2010 Importantly, pretreatment with the PKA inhibitor KT-5720 blocked the forskolin-induced CREB phosphorylation and prevented both the inhibition by forskolin of leptin-induced ERK1/2 and STAT3 phosphorylation and the PKA subunits down-regulation induced by the combination of leptin and forskolin. Colforsin 69-78 signal transducer and activator of transcription 3 Homo sapiens 184-189 20589829-6 2010 Importantly, pretreatment with the PKA inhibitor KT-5720 blocked the forskolin-induced CREB phosphorylation and prevented both the inhibition by forskolin of leptin-induced ERK1/2 and STAT3 phosphorylation and the PKA subunits down-regulation induced by the combination of leptin and forskolin. Colforsin 145-154 mitogen-activated protein kinase 3 Homo sapiens 173-179 20589829-6 2010 Importantly, pretreatment with the PKA inhibitor KT-5720 blocked the forskolin-induced CREB phosphorylation and prevented both the inhibition by forskolin of leptin-induced ERK1/2 and STAT3 phosphorylation and the PKA subunits down-regulation induced by the combination of leptin and forskolin. Colforsin 145-154 signal transducer and activator of transcription 3 Homo sapiens 184-189 20589829-6 2010 Importantly, pretreatment with the PKA inhibitor KT-5720 blocked the forskolin-induced CREB phosphorylation and prevented both the inhibition by forskolin of leptin-induced ERK1/2 and STAT3 phosphorylation and the PKA subunits down-regulation induced by the combination of leptin and forskolin. Colforsin 145-154 mitogen-activated protein kinase 3 Homo sapiens 173-179 20589829-6 2010 Importantly, pretreatment with the PKA inhibitor KT-5720 blocked the forskolin-induced CREB phosphorylation and prevented both the inhibition by forskolin of leptin-induced ERK1/2 and STAT3 phosphorylation and the PKA subunits down-regulation induced by the combination of leptin and forskolin. Colforsin 145-154 signal transducer and activator of transcription 3 Homo sapiens 184-189 20458731-2 2010 Here, we show that stimulating mitogenesis of Swiss 3T3 cells with phorbol esters or forskolin can induce divergent responses in the expression levels, localization and activation state of cyclin D1 and cyclin D3. Colforsin 85-94 cyclin D3 Mus musculus 203-212 20458731-3 2010 Phorbol ester-mediated protein kinase C stimulation induces S phase entry which is dependent on MAPK activation and increases the levels and activation of cyclin D1, whereas forskolin-mediated cAMP-dependent protein kinase A stimulation induces mitogenesis that is independent of MAPK, but dependent upon mTor and specifically increases the level and activation of cyclin D3. Colforsin 174-183 cyclin D3 Mus musculus 365-374 21273660-10 2010 The obtained results indicate that PGL, ALLO and THDOC inhibited basal and forskolin-induced CRH gene promoter activity in the differentiated Neuro-2A cells and that these effects did not depend on the activation of PI3-K/Akt and ERK-MAPK pathways. Colforsin 75-84 mitogen-activated protein kinase 1 Mus musculus 230-233 20722976-8 2010 The similar AQP2-LIR translocation was also demonstrated by forskolin and blocked by vasopressin/V2R specific antagonist, OPC31260 and protein kinase A (PKA) specific antagonists, H-89 and KT-5720. Colforsin 60-69 aquaporin 2 Homo sapiens 12-16 20722976-8 2010 The similar AQP2-LIR translocation was also demonstrated by forskolin and blocked by vasopressin/V2R specific antagonist, OPC31260 and protein kinase A (PKA) specific antagonists, H-89 and KT-5720. Colforsin 60-69 CD300c molecule Homo sapiens 17-20 20731759-4 2010 The regulation of alpha-synuclein expression was assessed by qPCR and western blot analysis in rat primary culture of ENS treated with KCl and forskolin. Colforsin 143-152 synuclein alpha Rattus norvegicus 18-33 20731759-7 2010 Depolarization and forskolin increased alpha-synuclein mRNA and protein expression in primary cultures of ENS, although L-type calcium channel and protein kinase A, respectively. Colforsin 19-28 synuclein, alpha Mus musculus 39-54 20731759-9 2010 An increase in alpha-synuclein expression was also observed in vivo in the ENS of mice injected with Bay K-8644 or forskolin. Colforsin 115-124 synuclein, alpha Mus musculus 15-30 21273660-6 2010 These neurosteroids also inhibited forskolin-stimulated CRH gene transcription with similar potency. Colforsin 35-44 corticotropin releasing hormone Homo sapiens 56-59 21273660-10 2010 The obtained results indicate that PGL, ALLO and THDOC inhibited basal and forskolin-induced CRH gene promoter activity in the differentiated Neuro-2A cells and that these effects did not depend on the activation of PI3-K/Akt and ERK-MAPK pathways. Colforsin 75-84 corticotropin releasing hormone Mus musculus 93-96 21273660-10 2010 The obtained results indicate that PGL, ALLO and THDOC inhibited basal and forskolin-induced CRH gene promoter activity in the differentiated Neuro-2A cells and that these effects did not depend on the activation of PI3-K/Akt and ERK-MAPK pathways. Colforsin 75-84 thymoma viral proto-oncogene 1 Mus musculus 222-225 21273660-10 2010 The obtained results indicate that PGL, ALLO and THDOC inhibited basal and forskolin-induced CRH gene promoter activity in the differentiated Neuro-2A cells and that these effects did not depend on the activation of PI3-K/Akt and ERK-MAPK pathways. Colforsin 75-84 mitogen-activated protein kinase 1 Homo sapiens 234-238 20696850-8 2010 In forskolin-stimulated BeWo cells that were hindered to fuse by treatment with H-89, levels of CGB protein expression were not altered, while LGALS13 protein and mRNA expression decreased significantly to control levels without forskolin. Colforsin 3-12 galectin 13 Homo sapiens 143-150 21034435-8 2010 In parallel, we demonstrated that AdipoR1 and AdipoR2 are up-regulated during forskolin induced BeWo cell differentiation, reinforcing the role of adiponectin in trophoblast syncytialization. Colforsin 78-87 adiponectin receptor 1 Homo sapiens 34-41 20845474-10 2010 The effects of DETA/NONOate were reversed by forskolin, an activator of CREB signaling. Colforsin 45-54 cAMP responsive element binding protein 1 Homo sapiens 72-76 21034435-8 2010 In parallel, we demonstrated that AdipoR1 and AdipoR2 are up-regulated during forskolin induced BeWo cell differentiation, reinforcing the role of adiponectin in trophoblast syncytialization. Colforsin 78-87 adiponectin receptor 2 Homo sapiens 46-53 21034435-8 2010 In parallel, we demonstrated that AdipoR1 and AdipoR2 are up-regulated during forskolin induced BeWo cell differentiation, reinforcing the role of adiponectin in trophoblast syncytialization. Colforsin 78-87 adiponectin, C1Q and collagen domain containing Homo sapiens 147-158 20675384-5 2010 Pin1 overexpression in HepG2 cells attenuated forskolin-induced nuclear localization of CRTC2 and cAMP-responsive element (CRE) transcriptional activity, whereas gene knockdown of Pin1 by siRNA enhanced both. Colforsin 46-55 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 0-4 20675384-5 2010 Pin1 overexpression in HepG2 cells attenuated forskolin-induced nuclear localization of CRTC2 and cAMP-responsive element (CRE) transcriptional activity, whereas gene knockdown of Pin1 by siRNA enhanced both. Colforsin 46-55 CREB regulated transcription coactivator 2 Homo sapiens 88-93 20675384-5 2010 Pin1 overexpression in HepG2 cells attenuated forskolin-induced nuclear localization of CRTC2 and cAMP-responsive element (CRE) transcriptional activity, whereas gene knockdown of Pin1 by siRNA enhanced both. Colforsin 46-55 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 180-184 20688914-3 2010 Deletion analysis of phosphoenolpyruvate carboxykinase (PEPCK) promoter demonstrated that SHP inhibited forskolin-mediated induction of PEPCK gene transcription via inhibition of CREB transcriptional activity. Colforsin 104-113 nuclear receptor subfamily 0, group B, member 2 Rattus norvegicus 90-93 20688914-3 2010 Deletion analysis of phosphoenolpyruvate carboxykinase (PEPCK) promoter demonstrated that SHP inhibited forskolin-mediated induction of PEPCK gene transcription via inhibition of CREB transcriptional activity. Colforsin 104-113 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 21-54 20688914-3 2010 Deletion analysis of phosphoenolpyruvate carboxykinase (PEPCK) promoter demonstrated that SHP inhibited forskolin-mediated induction of PEPCK gene transcription via inhibition of CREB transcriptional activity. Colforsin 104-113 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 136-141 20688914-3 2010 Deletion analysis of phosphoenolpyruvate carboxykinase (PEPCK) promoter demonstrated that SHP inhibited forskolin-mediated induction of PEPCK gene transcription via inhibition of CREB transcriptional activity. Colforsin 104-113 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 56-61 20688914-3 2010 Deletion analysis of phosphoenolpyruvate carboxykinase (PEPCK) promoter demonstrated that SHP inhibited forskolin-mediated induction of PEPCK gene transcription via inhibition of CREB transcriptional activity. Colforsin 104-113 cAMP responsive element binding protein 1 Rattus norvegicus 179-183 20727911-7 2010 We first showed that forskolin and phorbol ester activated an NR4A-dependent reporter gene indicating that members of the NR4A nuclear receptor family are present endogenously and upregulated by external stimuli. Colforsin 21-30 hepatic nuclear factor 4beta Gallus gallus 127-143 20682772-6 2010 Furthermore, we find that activation of protein kinase A (PKA) by forskolin reduces the recruitment of SHP2 to RET and negatively affects ligand-mediated neurite outgrowth. Colforsin 66-75 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 103-107 20682772-6 2010 Furthermore, we find that activation of protein kinase A (PKA) by forskolin reduces the recruitment of SHP2 to RET and negatively affects ligand-mediated neurite outgrowth. Colforsin 66-75 ret proto-oncogene Homo sapiens 111-114 20561511-5 2010 Forskolin (PKA activator) and H-89 (PKA inhibitor) also individually increased mIPSCs frequency, with an additional increase induced by co-incubation with bilirubin and H-89. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 11-14 20802507-10 2010 The ADM-mediated effects were similar to that of forskolin, which activates adenylyl cyclase; additionally, while the PKA inhibitor H89 and Ca2(+) chelator Fura-2 blocked the effect of ADM. Colforsin 49-58 adrenomedullin Rattus norvegicus 185-188 20685823-10 2010 PTH increased FGF23 mRNA levels (4-fold) and this effect was mimicked by a PKA activator, forskolin. Colforsin 90-99 parathyroid hormone Rattus norvegicus 0-3 20685823-10 2010 PTH increased FGF23 mRNA levels (4-fold) and this effect was mimicked by a PKA activator, forskolin. Colforsin 90-99 fibroblast growth factor 23 Rattus norvegicus 14-19 20675307-4 2010 The AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR; 1 mM), and cAMP activators forskolin (10 muM) and cholera toxin (200 ng/ml) also displayed the same effects. Colforsin 140-149 cathelicidin antimicrobial peptide Homo sapiens 124-128 20626586-4 2010 Functional analysis revealed that peak ALP levels induced by melatonin were accompanied by attenuation of melatonin-mediated inhibition of forskolin-induced cAMP accumulation. Colforsin 139-148 alkaline phosphatase, placental Homo sapiens 39-42 20663885-6 2010 Treatment of murine SMC with the PKA agonist forskolin stimulated RANKL expression at both mRNA and protein levels. Colforsin 45-54 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 66-71 20663885-7 2010 Forskolin also stimulated expression of interleukin-6 but not osteoprotegerin (OPG), an inhibitor of RANKL. Colforsin 0-9 interleukin 6 Homo sapiens 40-53 20803697-13 2010 In addition, forskolin reduced the phosphorylation of MLC (pMLC) and led to lack of accumulation of pMLC in the leading edge of CLPF. Colforsin 13-22 modulator of VRAC current 1 Homo sapiens 54-57 20660299-6 2010 Furthermore, the AKT-specific inhibitor abolished forskolin (FSK)-stimulated phosphorylation of AKT, tuberin, S6K1, and rpS6. Colforsin 50-59 AKT serine/threonine kinase 1 Homo sapiens 17-20 20660299-6 2010 Furthermore, the AKT-specific inhibitor abolished forskolin (FSK)-stimulated phosphorylation of AKT, tuberin, S6K1, and rpS6. Colforsin 50-59 AKT serine/threonine kinase 1 Homo sapiens 96-99 20660299-6 2010 Furthermore, the AKT-specific inhibitor abolished forskolin (FSK)-stimulated phosphorylation of AKT, tuberin, S6K1, and rpS6. Colforsin 50-59 TSC complex subunit 2 Homo sapiens 101-108 20660299-6 2010 Furthermore, the AKT-specific inhibitor abolished forskolin (FSK)-stimulated phosphorylation of AKT, tuberin, S6K1, and rpS6. Colforsin 50-59 ribosomal protein S6 kinase B1 Homo sapiens 110-114 20660299-6 2010 Furthermore, the AKT-specific inhibitor abolished forskolin (FSK)-stimulated phosphorylation of AKT, tuberin, S6K1, and rpS6. Colforsin 50-59 ribosomal protein S6 Homo sapiens 120-124 20660299-6 2010 Furthermore, the AKT-specific inhibitor abolished forskolin (FSK)-stimulated phosphorylation of AKT, tuberin, S6K1, and rpS6. Colforsin 61-64 AKT serine/threonine kinase 1 Homo sapiens 17-20 20660299-6 2010 Furthermore, the AKT-specific inhibitor abolished forskolin (FSK)-stimulated phosphorylation of AKT, tuberin, S6K1, and rpS6. Colforsin 61-64 AKT serine/threonine kinase 1 Homo sapiens 96-99 20660299-6 2010 Furthermore, the AKT-specific inhibitor abolished forskolin (FSK)-stimulated phosphorylation of AKT, tuberin, S6K1, and rpS6. Colforsin 61-64 TSC complex subunit 2 Homo sapiens 101-108 20660299-6 2010 Furthermore, the AKT-specific inhibitor abolished forskolin (FSK)-stimulated phosphorylation of AKT, tuberin, S6K1, and rpS6. Colforsin 61-64 ribosomal protein S6 kinase B1 Homo sapiens 110-114 20660299-6 2010 Furthermore, the AKT-specific inhibitor abolished forskolin (FSK)-stimulated phosphorylation of AKT, tuberin, S6K1, and rpS6. Colforsin 61-64 ribosomal protein S6 Homo sapiens 120-124 20660299-7 2010 Human CG and FSK-mediated phosphorylation of AKT and downstream targets of mTORC1 were attenuated by inhibition of adenylyl cyclase. Colforsin 13-16 AKT serine/threonine kinase 1 Homo sapiens 45-48 20660299-7 2010 Human CG and FSK-mediated phosphorylation of AKT and downstream targets of mTORC1 were attenuated by inhibition of adenylyl cyclase. Colforsin 13-16 CREB regulated transcription coactivator 1 Mus musculus 75-81 20660299-8 2010 Pharmacologic targeting of mTORC1 with rapamycin also abrogated hCG or FSK-induced phosphorylation of S6K1, rpS6, and eukaryotic initiation factor 4E binding protein 1. Colforsin 71-74 CREB regulated transcription coactivator 1 Mus musculus 27-33 20660299-8 2010 Pharmacologic targeting of mTORC1 with rapamycin also abrogated hCG or FSK-induced phosphorylation of S6K1, rpS6, and eukaryotic initiation factor 4E binding protein 1. Colforsin 71-74 ribosomal protein S6 kinase B1 Homo sapiens 102-106 20660299-8 2010 Pharmacologic targeting of mTORC1 with rapamycin also abrogated hCG or FSK-induced phosphorylation of S6K1, rpS6, and eukaryotic initiation factor 4E binding protein 1. Colforsin 71-74 ribosomal protein S6 Homo sapiens 108-112 20660299-9 2010 In addition, hCG or FSK-mediated up-regulation of the cell cycle regulatory proteins cyclin-dependent kinase 4, cyclin D3, and proliferating cell nuclear antigen was blocked by rapamycin. Colforsin 20-23 chorionic gonadotropin subunit beta 5 Homo sapiens 13-16 20660299-9 2010 In addition, hCG or FSK-mediated up-regulation of the cell cycle regulatory proteins cyclin-dependent kinase 4, cyclin D3, and proliferating cell nuclear antigen was blocked by rapamycin. Colforsin 20-23 cyclin dependent kinase 4 Homo sapiens 85-110 20660299-9 2010 In addition, hCG or FSK-mediated up-regulation of the cell cycle regulatory proteins cyclin-dependent kinase 4, cyclin D3, and proliferating cell nuclear antigen was blocked by rapamycin. Colforsin 20-23 cyclin D3 Homo sapiens 112-121 20380879-3 2010 Endogenous NTE activity was increased by cAMP-elevating chemicals, including dibutyryl cAMP, forskolin and forskolin plus 1-isobutyl-3-methylxanthine (IBMX), but decreased by the adenyl cyclase inhibitor SQ22536 which can reduce intracellular cAMP levels. Colforsin 93-102 patatin like phospholipase domain containing 6 Homo sapiens 11-14 20380879-3 2010 Endogenous NTE activity was increased by cAMP-elevating chemicals, including dibutyryl cAMP, forskolin and forskolin plus 1-isobutyl-3-methylxanthine (IBMX), but decreased by the adenyl cyclase inhibitor SQ22536 which can reduce intracellular cAMP levels. Colforsin 107-116 patatin like phospholipase domain containing 6 Homo sapiens 11-14 20380879-6 2010 The effect of the adenyl cyclase activator forskolin on NTE protein and mRNA levels was blocked by pretreatment with the protein kinase A (PKA) activity inhibitor H89. Colforsin 43-52 patatin like phospholipase domain containing 6 Homo sapiens 56-59 20656349-9 2010 RESULTS: We showed with immunocytochemical staining a downregulation of beta-catenin expression in the 24 h BeWo cell culture and with double immunofluorescence staining an inhibition of the beta-catenin and E-cadherin expression in the 48 h BeWo cell culture stimulated with gal-1 or forskolin. Colforsin 285-294 catenin beta 1 Homo sapiens 72-84 20043754-5 2010 Furthermore, hES cell-derived dopamine neurons showed cAMP elevations in response to forskolin and 3-isobutyl-methylxanthine, similar to primary dopamine neurons. Colforsin 85-94 ribosome binding protein 1 Homo sapiens 13-16 20434519-12 2010 Furthermore, in the presence of oocytes, the inhibition of endogenous FGF receptor signaling suppressed FSH- and forskolin-induced progesterone and cAMP, showing that endogenous FGF system is involved in activation of FSH-induced cAMP-PKA signaling via ERK and SAPK/JNK. Colforsin 113-122 Eph receptor B1 Rattus norvegicus 253-256 20434519-12 2010 Furthermore, in the presence of oocytes, the inhibition of endogenous FGF receptor signaling suppressed FSH- and forskolin-induced progesterone and cAMP, showing that endogenous FGF system is involved in activation of FSH-induced cAMP-PKA signaling via ERK and SAPK/JNK. Colforsin 113-122 mitogen-activated protein kinase 8 Rattus norvegicus 266-269 20554760-5 2010 This EGFR internalization is mimicked by PA micelles and is strongly counteracted by PLD2 silencing, rolipram or forskolin treatment, and PKA overexpression. Colforsin 113-122 epidermal growth factor receptor Homo sapiens 5-9 20824160-7 2010 RESULTS: Co-treatment with forskolin, which activates adenylate cyclase, and rolipram, which inhibits cAMP-dependent phosphodiesterase PDE4, reduced the TNF-alpha-induced increase in the flux of FITC-dextran. Colforsin 27-36 tumor necrosis factor Bos taurus 153-162 20824160-9 2010 Co-treatment, as well pre-treatment, with forskolin plus rolipram prevented the TNF-alpha-induced decrease in TER. Colforsin 42-51 tumor necrosis factor Bos taurus 80-89 20542497-7 2010 Treatment with an activator of adenylate cyclase, forskolin, or a cell-permeable analog of cAMP, 8-Br-cAMP, enhanced Ca(2+)-stimulated Fgf-2 expression, but a single treatment with forskolin or 8-Br-cAMP did not, suggesting that cAMP generation is indispensable but not sufficient for Ca(2+)-stimulated FGF2 expression. Colforsin 50-59 fibroblast growth factor 2 Homo sapiens 135-140 20663796-14 2010 Knockdown of Epac1 or Rap1 repressed the Db-, CPT- or forskolin-induced cell fusion. Colforsin 54-63 Rap guanine nucleotide exchange factor 3 Homo sapiens 13-18 20663796-14 2010 Knockdown of Epac1 or Rap1 repressed the Db-, CPT- or forskolin-induced cell fusion. Colforsin 54-63 RAP1A, member of RAS oncogene family Homo sapiens 22-26 20610537-6 2010 Conversely, when GCs from the Mapk14gc(-/-) mice were cultured with forskolin, they produced more Areg and Ereg mRNA than did wild-type GCs. Colforsin 68-77 mitogen-activated protein kinase 14 Mus musculus 30-36 20610537-6 2010 Conversely, when GCs from the Mapk14gc(-/-) mice were cultured with forskolin, they produced more Areg and Ereg mRNA than did wild-type GCs. Colforsin 68-77 amphiregulin Mus musculus 98-102 20610537-6 2010 Conversely, when GCs from the Mapk14gc(-/-) mice were cultured with forskolin, they produced more Areg and Ereg mRNA than did wild-type GCs. Colforsin 68-77 epiregulin Mus musculus 107-111 20580787-7 2010 JB-788 dose-dependently decreased forskolin-induced cAMP accumulation in HEK cells expressing human 5-HT(1A), thus acting as a potent 5-HT(1A) receptor agonist (E(max.) Colforsin 34-43 5-hydroxytryptamine receptor 1A Homo sapiens 100-107 20580787-7 2010 JB-788 dose-dependently decreased forskolin-induced cAMP accumulation in HEK cells expressing human 5-HT(1A), thus acting as a potent 5-HT(1A) receptor agonist (E(max.) Colforsin 34-43 5-hydroxytryptamine receptor 1A Homo sapiens 134-151 20735850-4 2010 RESULTS: To test this, we increased syt IV expression in PC12 cells by either upregulation with forskolin treatment or overexpression with transfection. Colforsin 96-105 synaptotagmin 4 Rattus norvegicus 36-42 20735850-7 2010 In syt I targeted cells with forskolin-induced syt IV upregulation, amperometry measurements showed a reduction in the number of release events and the total amount of transmitter molecules released per cell. Colforsin 29-38 synaptotagmin 1 Rattus norvegicus 3-8 20735850-7 2010 In syt I targeted cells with forskolin-induced syt IV upregulation, amperometry measurements showed a reduction in the number of release events and the total amount of transmitter molecules released per cell. Colforsin 29-38 synaptotagmin 4 Rattus norvegicus 47-53 20423724-6 2010 Adenylyl cyclase activation with forskolin mimicked the desensitization and selective inhibition of protein kinase A (PKA), but not protein kinase C (PKC), partially antagonized the desensitization induced by 5-HT. Colforsin 33-42 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 100-116 20423724-6 2010 Adenylyl cyclase activation with forskolin mimicked the desensitization and selective inhibition of protein kinase A (PKA), but not protein kinase C (PKC), partially antagonized the desensitization induced by 5-HT. Colforsin 33-42 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 118-121 21038678-9 2010 Compared with control group, platelet activating factor (PAF), forskolin and PMA could obviously stimulate PACAP mRNA expression in luteal cells which were cultured with corresponding factors for 24 h. At the same time, progesterone levels in culture media were also elevated. Colforsin 63-72 adenylate cyclase activating polypeptide 1 Rattus norvegicus 107-112 20385228-5 2010 Forskolin and Ex-4 also reduced TxNIP level in cultured primary rat islets. Colforsin 0-9 thioredoxin interacting protein Rattus norvegicus 32-37 20385228-6 2010 This repressive effect is at least partially mediated via stimulating proteasome-dependent TxNIP degradation, since the proteasomal inhibitor MG132, but not the lysosomal inhibitor chloroquine, significantly blocked the repressive effect of forskolin. Colforsin 241-250 thioredoxin interacting protein Rattus norvegicus 91-96 20385228-7 2010 Furthermore, forskolin enhanced TxNIP ubiquitination. Colforsin 13-22 thioredoxin interacting protein Rattus norvegicus 32-37 20385228-8 2010 Both PKA inhibition and Epac inhibition partially blocked the repressive effect of forskolin on TxNIP level. Colforsin 83-92 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 5-8 20385228-8 2010 Both PKA inhibition and Epac inhibition partially blocked the repressive effect of forskolin on TxNIP level. Colforsin 83-92 Rap guanine nucleotide exchange factor 3 Rattus norvegicus 24-28 20385228-8 2010 Both PKA inhibition and Epac inhibition partially blocked the repressive effect of forskolin on TxNIP level. Colforsin 83-92 thioredoxin interacting protein Rattus norvegicus 96-101 20385228-9 2010 In addition, forskolin and Ex-4 protected Ins-1 cells from high glucose-induced apoptotic activity, assessed by measuring caspase 3 activity. Colforsin 13-22 caspase 3 Rattus norvegicus 122-131 20385228-10 2010 Finally, knockdown of TxNIP expression led to reduced caspase 3 expression levels and blunted response to forskolin treatment. Colforsin 106-115 thioredoxin interacting protein Rattus norvegicus 22-27 20466058-6 2010 Forskolin depressed HGF-increased glucose-6-phosphate dehydrogenase (G6PD) activity and expression in RMC cultured in HG. Colforsin 0-9 hepatocyte growth factor Rattus norvegicus 20-23 20466058-6 2010 Forskolin depressed HGF-increased glucose-6-phosphate dehydrogenase (G6PD) activity and expression in RMC cultured in HG. Colforsin 0-9 glucose-6-phosphate dehydrogenase Rattus norvegicus 34-67 20466058-6 2010 Forskolin depressed HGF-increased glucose-6-phosphate dehydrogenase (G6PD) activity and expression in RMC cultured in HG. Colforsin 0-9 glucose-6-phosphate dehydrogenase Rattus norvegicus 69-73 20477910-8 2010 Activation of PKA by forskolin resulted in an enhanced S776 phosphorylation and increased ataxin-1 nuclear aggregation, which was suppressed by treatment with D2R agonist bromocriptine and PKA inhibitor H89. Colforsin 21-30 ataxin 1 Mus musculus 90-98 20477910-8 2010 Activation of PKA by forskolin resulted in an enhanced S776 phosphorylation and increased ataxin-1 nuclear aggregation, which was suppressed by treatment with D2R agonist bromocriptine and PKA inhibitor H89. Colforsin 21-30 dopamine receptor D2 Mus musculus 159-162 20477910-9 2010 Furthermore, treating SCA1 transgenic PC slice cultures with forskolin induced neurodegenerative morphological abnormalities in PC dendrites consistent with those observed in vivo. Colforsin 61-70 ataxin 1 Mus musculus 22-26 20226262-5 2010 In contrast, forskolin consistently contributed greater than 40% of total I(sc) in DeltaF508 CFTR-expressing FRT cells corrected with low temperature, and corr-4a treatment preferentially enhanced forskolin dependent currents only in FRT cells (60% of total I(sc)). Colforsin 13-22 CF transmembrane conductance regulator Homo sapiens 93-97 20451507-5 2010 Forskolin, which was known to increase CART mRNA levels in GH3 cells, was utilized to show that the drug increased levels of P-CREB protein and P-CREB binding to the CART promoter CRE-containing region. Colforsin 0-9 CART prepropeptide Rattus norvegicus 39-43 20451507-5 2010 Forskolin, which was known to increase CART mRNA levels in GH3 cells, was utilized to show that the drug increased levels of P-CREB protein and P-CREB binding to the CART promoter CRE-containing region. Colforsin 0-9 cAMP responsive element binding protein 1 Rattus norvegicus 127-131 20451507-5 2010 Forskolin, which was known to increase CART mRNA levels in GH3 cells, was utilized to show that the drug increased levels of P-CREB protein and P-CREB binding to the CART promoter CRE-containing region. Colforsin 0-9 cAMP responsive element binding protein 1 Rattus norvegicus 146-150 20451507-5 2010 Forskolin, which was known to increase CART mRNA levels in GH3 cells, was utilized to show that the drug increased levels of P-CREB protein and P-CREB binding to the CART promoter CRE-containing region. Colforsin 0-9 CART prepropeptide Rattus norvegicus 166-170 20517942-9 2010 We observed activation of CFTR Cl(-) channels with iodide efflux, on addition of forskolin, 3-isobutyl-1-methyl-xanthine, and 8-chlorphenylthio-cyclic adenosine monophosphate, in wild-type C57BL/6J isolated muscle fibers in contrast to no efflux from mutant F508del-CFTR muscle. Colforsin 81-90 CF transmembrane conductance regulator Homo sapiens 26-30 20346920-6 2010 It non-selectively activated the A(3)AR to inhibit forskolin-stimulated cAMP formation (IC(50) 66nM) and, similarly, protected A(3)-transfected HL-1 cells from apoptosis-inducing H(2)O(2) with greater potency (IC(50) 35nM) than monomeric nucleosides. Colforsin 51-60 adenosine A3 receptor Mus musculus 33-39 20448034-5 2010 Phorbol 12-myristate 13-acetate-, thrombin-, or forskolin-induced von Willebrand factor release or translocation of P-selectin from endothelial cells were inhibited by alpha- and beta-synuclein but not gamma-synuclein. Colforsin 48-57 selectin P Homo sapiens 116-126 20448034-5 2010 Phorbol 12-myristate 13-acetate-, thrombin-, or forskolin-induced von Willebrand factor release or translocation of P-selectin from endothelial cells were inhibited by alpha- and beta-synuclein but not gamma-synuclein. Colforsin 48-57 synuclein alpha Homo sapiens 179-193 20448034-5 2010 Phorbol 12-myristate 13-acetate-, thrombin-, or forskolin-induced von Willebrand factor release or translocation of P-selectin from endothelial cells were inhibited by alpha- and beta-synuclein but not gamma-synuclein. Colforsin 48-57 synuclein gamma Homo sapiens 202-217 20466003-4 2010 Activities of AC evoked by forskolin or a selective agonist of the V2 vasopressin receptor were lower in the kidneys of AC6-null mice compared to those of wildtype mice. Colforsin 27-36 adenylate cyclase 6 Mus musculus 120-123 20573894-6 2010 The effect of A(2A) receptor activation in TrkB localization was mimicked by 5 microm forskolin, an adenylyl cyclase activator. Colforsin 86-95 neurotrophic receptor tyrosine kinase 2 Homo sapiens 43-47 20403973-7 2010 When expressed in mIMCD-3 cells, forskolin treatment efficiently promoted the targeting of AQP2-wt at the plasma membrane (>90%) while K228E only weakly responded to the same treatment (approximately 20%) and both V24A and R187C remained completely insensitive to the treatment. Colforsin 33-42 aquaporin 2 Mus musculus 91-95 20519125-2 2010 These opposing effects on glucagon secretion are mimicked by low (1-10 nM) and high (10 muM) concentrations of forskolin, respectively. Colforsin 111-120 latexin Homo sapiens 88-91 20457835-5 2010 PGE(2) induces IL-6 mRNA and protein expression via a cAMP-dependent pathway, reaching maximal levels after 60 min of stimulation before declining to baseline levels at 6 h. Forskolin, an adenylyl cyclase activator, also stimulates IL-6 expression in human chondrocytes in a dose- and time-dependent fashion. Colforsin 174-183 interleukin 6 Homo sapiens 15-19 20457835-5 2010 PGE(2) induces IL-6 mRNA and protein expression via a cAMP-dependent pathway, reaching maximal levels after 60 min of stimulation before declining to baseline levels at 6 h. Forskolin, an adenylyl cyclase activator, also stimulates IL-6 expression in human chondrocytes in a dose- and time-dependent fashion. Colforsin 174-183 interleukin 6 Homo sapiens 232-236 20457835-6 2010 Inhibition of downstream effectors of cAMP activity such as protein kinase A (PKA) or phosphatidylinositol 3 kinase (PI3K) blocks PGE(2)- and forskolin-induced IL-6 upregulation. Colforsin 142-151 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 86-115 20457835-6 2010 Inhibition of downstream effectors of cAMP activity such as protein kinase A (PKA) or phosphatidylinositol 3 kinase (PI3K) blocks PGE(2)- and forskolin-induced IL-6 upregulation. Colforsin 142-151 interleukin 6 Homo sapiens 160-164 20457835-9 2010 p65 knockdown completely abrogates IL-6 mRNA synthesis in PGE(2)- and forskolin-primed chondrocytes. Colforsin 70-79 RELA proto-oncogene, NF-kB subunit Homo sapiens 0-3 20457835-9 2010 p65 knockdown completely abrogates IL-6 mRNA synthesis in PGE(2)- and forskolin-primed chondrocytes. Colforsin 70-79 interleukin 6 Homo sapiens 35-39 20457835-10 2010 Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter. Colforsin 44-53 interleukin 6 Homo sapiens 61-65 20457835-10 2010 Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter. Colforsin 44-53 RELA proto-oncogene, NF-kB subunit Homo sapiens 194-197 20457835-10 2010 Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter. Colforsin 44-53 interleukin 6 Homo sapiens 205-209 20202976-11 2010 FSK activated the MLCP catalytic subunit PP1 via dephosphorylation and dissociation of the PP1 inhibitory protein CPI-17. Colforsin 0-3 neuropeptide Y receptor Y4 Homo sapiens 41-44 20202976-11 2010 FSK activated the MLCP catalytic subunit PP1 via dephosphorylation and dissociation of the PP1 inhibitory protein CPI-17. Colforsin 0-3 neuropeptide Y receptor Y4 Homo sapiens 91-94 20202976-11 2010 FSK activated the MLCP catalytic subunit PP1 via dephosphorylation and dissociation of the PP1 inhibitory protein CPI-17. Colforsin 0-3 protein phosphatase 1 regulatory inhibitor subunit 14A Homo sapiens 114-120 20202976-12 2010 FSK blunted thrombin-induced CPI-17 phosphorylation, CPI-17/PP1 complex formation, and PP1 inactivation. Colforsin 0-3 coagulation factor II, thrombin Homo sapiens 12-20 20202976-12 2010 FSK blunted thrombin-induced CPI-17 phosphorylation, CPI-17/PP1 complex formation, and PP1 inactivation. Colforsin 0-3 protein phosphatase 1 regulatory inhibitor subunit 14A Homo sapiens 29-35 20202976-12 2010 FSK blunted thrombin-induced CPI-17 phosphorylation, CPI-17/PP1 complex formation, and PP1 inactivation. Colforsin 0-3 protein phosphatase 1 regulatory inhibitor subunit 14A Homo sapiens 53-59 20202976-12 2010 FSK blunted thrombin-induced CPI-17 phosphorylation, CPI-17/PP1 complex formation, and PP1 inactivation. Colforsin 0-3 neuropeptide Y receptor Y4 Homo sapiens 60-63 20202976-12 2010 FSK blunted thrombin-induced CPI-17 phosphorylation, CPI-17/PP1 complex formation, and PP1 inactivation. Colforsin 0-3 neuropeptide Y receptor Y4 Homo sapiens 87-90 20375258-8 2010 Regulation studies demonstrated that Furin mRNA was induced in residual tissue by forskolin or amphiregulin. Colforsin 82-91 furin (paired basic amino acid cleaving enzyme) Rattus norvegicus 37-42 20406739-4 2010 The whole-cell patch-clamp recording revealed a forskolin (FSK)-activated current with electrophysiological and pharmacological characteristics of CFTR. Colforsin 48-57 CF transmembrane conductance regulator Homo sapiens 147-151 20406739-4 2010 The whole-cell patch-clamp recording revealed a forskolin (FSK)-activated current with electrophysiological and pharmacological characteristics of CFTR. Colforsin 59-62 CF transmembrane conductance regulator Homo sapiens 147-151 20406739-5 2010 The I(sc) measurement showed that FSK-stimulated an increase in the I(sc), which could be significantly reduced by CFTR inhibitor or removal of both CO(2) and HCO(3)(-). Colforsin 34-37 CF transmembrane conductance regulator Homo sapiens 115-119 20406739-6 2010 pH measurement showed a FSK stimulated alkalization at the apical surface, which could be inhibited by CFTR inhibitor, indicating CFTR-mediated HCO(3)(-) secretion. Colforsin 24-27 CF transmembrane conductance regulator Homo sapiens 103-107 20406739-6 2010 pH measurement showed a FSK stimulated alkalization at the apical surface, which could be inhibited by CFTR inhibitor, indicating CFTR-mediated HCO(3)(-) secretion. Colforsin 24-27 CF transmembrane conductance regulator Homo sapiens 130-134 20564725-6 2010 The cAMP elevating agonist (forskolin) was added to stimulate cystic fibrosis transmembrane conductance regulator-mediated Cl secretion. Colforsin 28-37 CF transmembrane conductance regulator Homo sapiens 62-113 21977288-7 2010 Activation of PKA by forskolin or PKC by PMA resulted in a level of CREB phosphorylation comparable to the reduced level of the strain-induced CREB phosphorylation in the presence of PKA or PKC inhibitors. Colforsin 21-30 cAMP responsive element binding protein 1 Rattus norvegicus 68-72 20362570-3 2010 In contrast, menthol potentiated forskolin-stimulated and -unstimulated apical Cl(-) conductance, which reflected the cystic fibrosis transmembrane conductance regulator (CFTR: the cAMP-regulated Cl(-) channel)-mediated conductance, without correlation to changes in cytosolic cAMP levels. Colforsin 33-42 CF transmembrane conductance regulator Homo sapiens 118-169 20362570-3 2010 In contrast, menthol potentiated forskolin-stimulated and -unstimulated apical Cl(-) conductance, which reflected the cystic fibrosis transmembrane conductance regulator (CFTR: the cAMP-regulated Cl(-) channel)-mediated conductance, without correlation to changes in cytosolic cAMP levels. Colforsin 33-42 CF transmembrane conductance regulator Homo sapiens 171-175 20362570-5 2010 Analyses of the responsible basolateral anion transporters revealed that forskolin increased both bumetanide (an inhibitor of the basolateral Na(+)-K(+)-2Cl(-) cotransporter [NKCC1])- and DNDS (an inhibitor of basolateral HCO(3)(-)-dependent anion transporters [NBC1/AE2])-sensitive I(SC) in the control whereas only the former was prevented by the application of menthol. Colforsin 73-82 solute carrier family 12 member 2 Homo sapiens 175-180 20362570-5 2010 Analyses of the responsible basolateral anion transporters revealed that forskolin increased both bumetanide (an inhibitor of the basolateral Na(+)-K(+)-2Cl(-) cotransporter [NKCC1])- and DNDS (an inhibitor of basolateral HCO(3)(-)-dependent anion transporters [NBC1/AE2])-sensitive I(SC) in the control whereas only the former was prevented by the application of menthol. Colforsin 73-82 solute carrier family 4 member 4 Homo sapiens 262-266 20362570-5 2010 Analyses of the responsible basolateral anion transporters revealed that forskolin increased both bumetanide (an inhibitor of the basolateral Na(+)-K(+)-2Cl(-) cotransporter [NKCC1])- and DNDS (an inhibitor of basolateral HCO(3)(-)-dependent anion transporters [NBC1/AE2])-sensitive I(SC) in the control whereas only the former was prevented by the application of menthol. Colforsin 73-82 NBPF member 3 Homo sapiens 267-270 20171993-4 2010 Forskolin, which stimulates adenylate cyclase and then increases intracellular cAMP production, was shown to transiently decrease Ucn1 and Ucn2 mRNA levels, but increase Ucns 1-3 mRNA levels in H295R cells. Colforsin 0-9 urocortin 2 Homo sapiens 139-143 20360004-6 2010 Forskolin or epinephrine induced localized Rac activation dependent on Tiam1 and spinophilin. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 43-46 20360004-6 2010 Forskolin or epinephrine induced localized Rac activation dependent on Tiam1 and spinophilin. Colforsin 0-9 TIAM Rac1 associated GEF 1 Homo sapiens 71-76 20360004-8 2010 In IRSp53-deficient cells, Tiam1 co-localized with spinophilin in response to forskolin or epinephrine. Colforsin 78-87 BAR/IMD domain containing adaptor protein 2 Homo sapiens 3-9 20360004-8 2010 In IRSp53-deficient cells, Tiam1 co-localized with spinophilin in response to forskolin or epinephrine. Colforsin 78-87 TIAM Rac1 associated GEF 1 Homo sapiens 27-32 20378682-7 2010 Ten micromolar forskolin doubled the ovulatory rate of ERbeta-null follicles compared with treatment with hCG ( approximately 50 vs. 25%, respectively). Colforsin 15-24 estrogen receptor 2 Homo sapiens 55-61 20308529-4 2010 Treatment of granulosa cells with forskolin to mimic the effects of LH increases AREG promoter activity in a RIP140-dependent manner that 1) requires an intact cAMP response element in the proximal promoter region of the Areg gene and 2) involves its actions as a coactivator for cAMP response element-binding protein/c-Jun transcription factors. Colforsin 34-43 amphiregulin Mus musculus 81-85 20308529-4 2010 Treatment of granulosa cells with forskolin to mimic the effects of LH increases AREG promoter activity in a RIP140-dependent manner that 1) requires an intact cAMP response element in the proximal promoter region of the Areg gene and 2) involves its actions as a coactivator for cAMP response element-binding protein/c-Jun transcription factors. Colforsin 34-43 nuclear receptor interacting protein 1 Mus musculus 109-115 20308529-4 2010 Treatment of granulosa cells with forskolin to mimic the effects of LH increases AREG promoter activity in a RIP140-dependent manner that 1) requires an intact cAMP response element in the proximal promoter region of the Areg gene and 2) involves its actions as a coactivator for cAMP response element-binding protein/c-Jun transcription factors. Colforsin 34-43 amphiregulin Homo sapiens 221-225 20308529-4 2010 Treatment of granulosa cells with forskolin to mimic the effects of LH increases AREG promoter activity in a RIP140-dependent manner that 1) requires an intact cAMP response element in the proximal promoter region of the Areg gene and 2) involves its actions as a coactivator for cAMP response element-binding protein/c-Jun transcription factors. Colforsin 34-43 jun proto-oncogene Mus musculus 318-323 20378682-9 2010 A 10 microm concentration of forskolin induced cAMP levels in ERbeta-null follicles that were comparable to levels produced in WT follicles after hCG and either partially or completely rescued the attenuated expression of LH-responsive genes. Colforsin 29-38 estrogen receptor 2 Homo sapiens 62-68 20378682-9 2010 A 10 microm concentration of forskolin induced cAMP levels in ERbeta-null follicles that were comparable to levels produced in WT follicles after hCG and either partially or completely rescued the attenuated expression of LH-responsive genes. Colforsin 29-38 chorionic gonadotropin subunit beta 5 Homo sapiens 146-149 20360313-7 2010 In primary cultures of renin-rich kidney cells, NaHS markedly suppressed forskolin-stimulated renin activity in the medium and the intracellular increase in cAMP. Colforsin 73-82 renin Rattus norvegicus 23-28 20107853-7 2010 Here, we show that FSK-induced supporting cell proliferation is mediated by cell-specific accumulation of cyclic adenosine monophosphate (cAMP) in avian supporting cells and the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. Colforsin 19-22 mitogen-activated protein kinase 1 Homo sapiens 178-215 20360313-7 2010 In primary cultures of renin-rich kidney cells, NaHS markedly suppressed forskolin-stimulated renin activity in the medium and the intracellular increase in cAMP. Colforsin 73-82 renin Rattus norvegicus 94-99 20107853-7 2010 Here, we show that FSK-induced supporting cell proliferation is mediated by cell-specific accumulation of cyclic adenosine monophosphate (cAMP) in avian supporting cells and the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. Colforsin 19-22 mitogen-activated protein kinase 1 Homo sapiens 217-220 20203064-7 2010 Moreover, pretreatment of T(84) cells with leptin for up to 1 h significantly potentiated carbachol- and forskolin-induced increases in I(sc). Colforsin 105-114 leptin Rattus norvegicus 43-49 20107853-7 2010 Here, we show that FSK-induced supporting cell proliferation is mediated by cell-specific accumulation of cyclic adenosine monophosphate (cAMP) in avian supporting cells and the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. Colforsin 19-22 mitogen-activated protein kinase 1 Homo sapiens 256-260 20107853-8 2010 By a combination of immunostaining and pharmacological analyses, we show that FSK treatment increases cAMP levels in avian auditory supporting cells and that several ERK MAP inhibitors effectively block FSK-induced supporting cell proliferation. Colforsin 203-206 mitogen-activated protein kinase 1 Homo sapiens 166-169 20107853-10 2010 Collectively, these data suggest that FSK-induced supporting cell proliferation in the avian auditory epithelium is mediated by increases of cAMP levels in supporting cells and the cell-specific expression of the ERK MAPK family member B-Raf in supporting cells. Colforsin 38-41 mitogen-activated protein kinase 1 Homo sapiens 213-216 20107853-10 2010 Collectively, these data suggest that FSK-induced supporting cell proliferation in the avian auditory epithelium is mediated by increases of cAMP levels in supporting cells and the cell-specific expression of the ERK MAPK family member B-Raf in supporting cells. Colforsin 38-41 mitogen-activated protein kinase 1 Homo sapiens 217-221 20107853-10 2010 Collectively, these data suggest that FSK-induced supporting cell proliferation in the avian auditory epithelium is mediated by increases of cAMP levels in supporting cells and the cell-specific expression of the ERK MAPK family member B-Raf in supporting cells. Colforsin 38-41 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 236-241 20200141-9 2010 Incubating polarized CFBE41o(-) monolayers and intestines isolated from Delta Phe508-CFTR mice (treated ex vivo) with glafenine increased the short-circuit current (I(sc)) response to forskolin + genistein, and this effect was abolished by 10 microM CFTR(inh)172. Colforsin 184-193 cystic fibrosis transmembrane conductance regulator Mus musculus 250-254 20360002-5 2010 The transcriptional activity of NF-kappaB was significantly enhanced by treatment with forskolin, indicating these two signals converge for maximal activation. Colforsin 87-96 nuclear factor kappa B subunit 1 Homo sapiens 32-41 20442331-4 2010 Forskolin, a protein kinase A pathway agonist which can induce Klf4 and Klf2 expression, transiently substitutes for the requirement for ectopic transgene expression. Colforsin 0-9 Kruppel like factor 4 Homo sapiens 63-67 20442331-4 2010 Forskolin, a protein kinase A pathway agonist which can induce Klf4 and Klf2 expression, transiently substitutes for the requirement for ectopic transgene expression. Colforsin 0-9 Kruppel like factor 2 Homo sapiens 72-76 20083153-10 2010 Since expression of NR4A1 in the endocrine organs is known to be regulated by both cAMP/PKA mediated hormones, ACTH and LH, forskolin (FSK), an activator of cAMP/PKA pathway, was applied to the cultured follicles. Colforsin 124-133 nuclear receptor subfamily 4, group A, member 1 Mus musculus 20-25 20083153-10 2010 Since expression of NR4A1 in the endocrine organs is known to be regulated by both cAMP/PKA mediated hormones, ACTH and LH, forskolin (FSK), an activator of cAMP/PKA pathway, was applied to the cultured follicles. Colforsin 135-138 nuclear receptor subfamily 4, group A, member 1 Mus musculus 20-25 20083153-11 2010 FSK rapidly increases the NR4A1 mRNA levels followed by an increase in StAR, CYP11A1, CYP17 and HSD3B2. Colforsin 0-3 nuclear receptor subfamily 4, group A, member 1 Mus musculus 26-31 20083153-11 2010 FSK rapidly increases the NR4A1 mRNA levels followed by an increase in StAR, CYP11A1, CYP17 and HSD3B2. Colforsin 0-3 steroidogenic acute regulatory protein Mus musculus 71-75 20083153-11 2010 FSK rapidly increases the NR4A1 mRNA levels followed by an increase in StAR, CYP11A1, CYP17 and HSD3B2. Colforsin 0-3 cytochrome P450, family 11, subfamily a, polypeptide 1 Mus musculus 77-84 20083153-11 2010 FSK rapidly increases the NR4A1 mRNA levels followed by an increase in StAR, CYP11A1, CYP17 and HSD3B2. Colforsin 0-3 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 86-91 20083153-11 2010 FSK rapidly increases the NR4A1 mRNA levels followed by an increase in StAR, CYP11A1, CYP17 and HSD3B2. Colforsin 0-3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Mus musculus 96-102 20203064-8 2010 Pretreatment with an inhibitor of MAPK abolished the effect of leptin on basal, carbachol- and forskolin-induced chloride secretion (P < 0.05). Colforsin 95-104 leptin Rattus norvegicus 63-69 20203064-9 2010 However, the PI3K inhibitor, wortmannin, only blunted the effect of leptin on forskolin-induced increases in I(sc). Colforsin 78-87 leptin Rattus norvegicus 68-74 20159943-1 2010 Relaxin family peptide 3 receptors (RXFP3) are activated by H3-relaxin to inhibit forskolin-stimulated cAMP accumulation and stimulate extracellular signal-regulated kinase (ERK) 1/2 phosphorylation. Colforsin 82-91 relaxin family peptide receptor 3 Mus musculus 0-34 20512473-9 2010 Moreover, CRE promoter activity was dose-dependently inhibited by PAO and the increased secretion of IL-12p40 by PAO was reduced by forskolin, a cAMP activator. Colforsin 132-141 cathelicidin antimicrobial peptide Homo sapiens 145-149 20337700-4 2010 Human chorionic gonadotropin and fibroblast growth factor-9 were as potent as forskolin in activating StAR to enhance testosterone production, while interleukin-1 beta, dexamethasone, insulin and insulin-like growth factor-1 showed no stimulatory effect. Colforsin 78-87 steroidogenic acute regulatory protein Homo sapiens 102-106 20359690-7 2010 Forskolin enhanced VIP-induced vasorelaxation in control rings but this effect was reduced started from 30 min of occlusion. Colforsin 0-9 VIP peptides Oryctolagus cuniculus 19-22 20400641-8 2010 We found that NKCC1 phosphorylation is acutely regulated in the killifish gill in response to changing environmental salinity and that phosphorylation in excised gills increases in response to forskolin stimulation of the cAMP-PKA pathway. Colforsin 193-202 solute carrier family 12 member 2 Fundulus heteroclitus 14-19 20159943-1 2010 Relaxin family peptide 3 receptors (RXFP3) are activated by H3-relaxin to inhibit forskolin-stimulated cAMP accumulation and stimulate extracellular signal-regulated kinase (ERK) 1/2 phosphorylation. Colforsin 82-91 relaxin family peptide receptor 3 Mus musculus 36-41 20384487-5 2010 METHODS: Cultured nondifferentiated orbital fibroblasts obtained during orbital decompression surgery from 15 GO patients were stimulated with recombinant human TSH (rhTSH), TSHR-stimulating Graves" disease immunoglobulin G (GD-IgG) or forskolin (FSK), or interleukin-1beta (IL-1beta). Colforsin 236-245 thyroid stimulating hormone receptor Homo sapiens 174-178 20347141-4 2010 Five different cell lines were triggered with forskolin and cultured for 48 h. Amongst the five tested cell lines BeWo cells showed the strongest increase in PP13 mRNA after forskolin treatment compared to controls. Colforsin 46-55 galectin 13 Homo sapiens 158-162 20347141-4 2010 Five different cell lines were triggered with forskolin and cultured for 48 h. Amongst the five tested cell lines BeWo cells showed the strongest increase in PP13 mRNA after forskolin treatment compared to controls. Colforsin 174-183 galectin 13 Homo sapiens 158-162 20384487-5 2010 METHODS: Cultured nondifferentiated orbital fibroblasts obtained during orbital decompression surgery from 15 GO patients were stimulated with recombinant human TSH (rhTSH), TSHR-stimulating Graves" disease immunoglobulin G (GD-IgG) or forskolin (FSK), or interleukin-1beta (IL-1beta). Colforsin 247-250 thyroid stimulating hormone receptor Homo sapiens 174-178 20384487-6 2010 RESULTS: FSK significantly stimulated cAMP production, HAS1 and HAS3 mRNA expression, and HA secretion in orbital fibroblasts. Colforsin 9-12 hyaluronan synthase 1 Homo sapiens 55-59 20384487-6 2010 RESULTS: FSK significantly stimulated cAMP production, HAS1 and HAS3 mRNA expression, and HA secretion in orbital fibroblasts. Colforsin 9-12 hyaluronan synthase 3 Homo sapiens 64-68 20071460-5 2010 Forskolin stimulates urea flux in the wild-type UT-A1-mIMCD3 cells but not in the S486A/S499A-UT-A1-mIMCD3 cells. Colforsin 0-9 solute carrier family 14 (urea transporter), member 2 Mus musculus 48-53 20335821-0 2010 GlyT-2 mediates the forskolin-induced increase of glycinergic transmission. Colforsin 20-29 solute carrier family 6 member 5 Rattus norvegicus 0-6 20335821-1 2010 In this study, we have examined the possible roles of a glycine transporter type 2 (GlyT-2) in the forskolin-induced increase of the amplitude of glycinergic miniature inhibitory postsynaptic currents (mIPSCs) in acutely isolated rat substantia gelatinosa neurons. Colforsin 99-108 solute carrier family 6 member 5 Rattus norvegicus 56-82 20106966-6 2010 Binding to mAKAP is required for PP2A function, such that deletion of the C-terminal domain enhances both base-line and forskolin-stimulated PDE4D3 activity. Colforsin 120-129 A kinase (PRKA) anchor protein 1 Mus musculus 11-16 20106966-6 2010 Binding to mAKAP is required for PP2A function, such that deletion of the C-terminal domain enhances both base-line and forskolin-stimulated PDE4D3 activity. Colforsin 120-129 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 33-37 20106966-6 2010 Binding to mAKAP is required for PP2A function, such that deletion of the C-terminal domain enhances both base-line and forskolin-stimulated PDE4D3 activity. Colforsin 120-129 phosphodiesterase 4D, cAMP specific Mus musculus 141-146 20107043-6 2010 In HFD visceral adipocytes, activation of adenylyl cyclases by forskolin increased HSL phosphorylation and surpassed the lipolytic response of control cells. Colforsin 63-72 lipase, hormone sensitive Mus musculus 83-86 20071460-7 2010 In rat IMCDs, forskolin increased the abundance of phospho-S486-UT-A1 (measured using the phospho-S486 antibody) and of total UT-A1 phosphorylation (measured by (32)P incorporation). Colforsin 14-23 solute carrier family 14 (urea transporter), member 2 Mus musculus 64-69 20071460-7 2010 In rat IMCDs, forskolin increased the abundance of phospho-S486-UT-A1 (measured using the phospho-S486 antibody) and of total UT-A1 phosphorylation (measured by (32)P incorporation). Colforsin 14-23 solute carrier family 14 (urea transporter), member 2 Mus musculus 126-131 20071460-8 2010 Forskolin also increased the plasma membrane accumulation of phospho-S486-UT-A1 in rat IMCD suspensions, as measured by biotinylation. Colforsin 0-9 solute carrier family 14 (urea transporter), member 2 Mus musculus 74-79 20096281-4 2010 In phenylephrine-contracted rings without endothelium, relaxations induced by isoprenaline (receptor-mediated) and forskolin (receptor-independent) were markedly reduced by the presence of a prostanoid TP receptor agonist, U46619; the attenuated relaxations were prevented by acute treatment with S18886, the selective prostanoid TP receptor antagonist, but not by protein kinase C inhibitors. Colforsin 115-124 thromboxane A2 receptor Rattus norvegicus 191-213 20096281-4 2010 In phenylephrine-contracted rings without endothelium, relaxations induced by isoprenaline (receptor-mediated) and forskolin (receptor-independent) were markedly reduced by the presence of a prostanoid TP receptor agonist, U46619; the attenuated relaxations were prevented by acute treatment with S18886, the selective prostanoid TP receptor antagonist, but not by protein kinase C inhibitors. Colforsin 115-124 thromboxane A2 receptor Rattus norvegicus 319-341 20335821-1 2010 In this study, we have examined the possible roles of a glycine transporter type 2 (GlyT-2) in the forskolin-induced increase of the amplitude of glycinergic miniature inhibitory postsynaptic currents (mIPSCs) in acutely isolated rat substantia gelatinosa neurons. Colforsin 99-108 solute carrier family 6 member 5 Rattus norvegicus 84-90 20335821-4 2010 These results suggest that both extracellular glycine and GlyT-2 are essential for the forskolin-induced increase in the amplitude of glycinergic mIPSCs. Colforsin 87-96 solute carrier family 6 member 5 Rattus norvegicus 58-64 20460737-7 2010 Accumulation of cAMP could be induced by cAMP-elevating agents (forskolin, isobutylmethylxanthine and mastparan) but was not reduced by treatment with C(2)-ceramide. Colforsin 64-73 cathelicidin antimicrobial peptide Homo sapiens 16-20 20460737-7 2010 Accumulation of cAMP could be induced by cAMP-elevating agents (forskolin, isobutylmethylxanthine and mastparan) but was not reduced by treatment with C(2)-ceramide. Colforsin 64-73 cathelicidin antimicrobial peptide Homo sapiens 41-45 19955695-7 2010 Furthermore, basal and forskolin-stimulated intracellular cAMP was potently increased in RKIP(+) cells versus controls. Colforsin 23-32 phosphatidylethanolamine binding protein 1 Homo sapiens 89-93 20332211-8 2010 NPY inhibited forskolin-stimulated cyclic AMP accumulation with an IC(50) value of 52 pmol/L. Colforsin 14-23 neuropeptide Y Homo sapiens 0-3 20423611-4 2010 Inhibitory tyrosine phosphorylation on Tyr-307 of the PP2A catalytic C subunit was decreased after forskolin treatment. Colforsin 99-108 protein phosphatase 2 phosphatase activator Homo sapiens 54-58 19821778-6 2010 Both PTH and forskolin, an activator of adenylyl cyclase, stimulated NFATc1 nuclear translocation. Colforsin 13-22 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 Mus musculus 69-75 19821778-7 2010 PTH- and forskolin-stimulated COX-2 promoter activity was inhibited 56% to 80% by calcium chelation or calcineurin inhibitors and 60% to 98% by protein kinase A (PKA) inhibitors. Colforsin 9-18 prostaglandin-endoperoxide synthase 2 Mus musculus 30-35 20081152-9 2010 The only peptides that exhibited a statistically significant decrease in secretion on forskolin stimulation were derived from annexin A1 and calcyclin. Colforsin 86-95 annexin A1 Mus musculus 126-136 20081152-9 2010 The only peptides that exhibited a statistically significant decrease in secretion on forskolin stimulation were derived from annexin A1 and calcyclin. Colforsin 86-95 S100 calcium binding protein A6 (calcyclin) Mus musculus 141-150 20053791-0 2010 CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells. Colforsin 69-78 cAMP responsive element binding protein 1 Homo sapiens 0-4 20053791-0 2010 CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells. Colforsin 69-78 cellular communication network factor 2 Homo sapiens 93-97 20053791-2 2010 The adenylyl cyclase agonist forskolin inhibits CTGF expression in mesangial cells by unclear mechanisms. Colforsin 29-38 cellular communication network factor 2 Homo sapiens 48-52 20053791-4 2010 In the present study, we characterized the involvement of Dot1 in mediating the inhibitory effect of forskolin on CTGF transcription in mouse mesangial cells. Colforsin 101-110 cellular communication network factor 2 Mus musculus 114-118 20053791-5 2010 Overexpression of Dot1 or treatment with forskolin dramatically suppressed basal CTGF mRNA levels and CTGF promoter-luciferase activity, while hypermethylating H3K79 in chromatin associated with the CTGF promoter. Colforsin 41-50 cellular communication network factor 2 Homo sapiens 81-85 20053791-5 2010 Overexpression of Dot1 or treatment with forskolin dramatically suppressed basal CTGF mRNA levels and CTGF promoter-luciferase activity, while hypermethylating H3K79 in chromatin associated with the CTGF promoter. Colforsin 41-50 cellular communication network factor 2 Homo sapiens 102-106 20053791-5 2010 Overexpression of Dot1 or treatment with forskolin dramatically suppressed basal CTGF mRNA levels and CTGF promoter-luciferase activity, while hypermethylating H3K79 in chromatin associated with the CTGF promoter. Colforsin 41-50 cellular communication network factor 2 Homo sapiens 102-106 20053791-6 2010 siRNA knockdown of Dot1 abrogated the inhibitory effect of forskolin on CTGF mRNA expression. Colforsin 59-68 cellular communication network factor 2 Homo sapiens 72-76 20053791-8 2010 Overexpression of CREB enhanced forskolin-stimulated Dot1 promoter activity. Colforsin 32-41 cAMP responsive element binding protein 1 Homo sapiens 18-22 20053791-12 2010 We conclude that forskolin stimulates CREB-mediated trans-activation of the Dot1 gene, which leads to hypermethylation of histone H3K79 at the CTGF promoter, and inhibition of CTGF transcription. Colforsin 17-26 cAMP responsive element binding protein 1 Homo sapiens 38-42 20053791-12 2010 We conclude that forskolin stimulates CREB-mediated trans-activation of the Dot1 gene, which leads to hypermethylation of histone H3K79 at the CTGF promoter, and inhibition of CTGF transcription. Colforsin 17-26 cellular communication network factor 2 Homo sapiens 143-147 20053791-12 2010 We conclude that forskolin stimulates CREB-mediated trans-activation of the Dot1 gene, which leads to hypermethylation of histone H3K79 at the CTGF promoter, and inhibition of CTGF transcription. Colforsin 17-26 cellular communication network factor 2 Homo sapiens 176-180 20080871-3 2010 Immunohistochemistry and Western blot experiments in 4B cells revealed time-dependent nuclear translocation of TORC1,TORC 2, and TORC3 by forskolin [but not by the phorbol ester, phorbol 12-myristate 13-acetate (PMA)] in a concentration-dependent manner. Colforsin 138-147 CREB regulated transcription coactivator 1 Homo sapiens 111-116 20080871-3 2010 Immunohistochemistry and Western blot experiments in 4B cells revealed time-dependent nuclear translocation of TORC1,TORC 2, and TORC3 by forskolin [but not by the phorbol ester, phorbol 12-myristate 13-acetate (PMA)] in a concentration-dependent manner. Colforsin 138-147 CREB regulated transcription coactivator 2 Homo sapiens 117-123 20032304-9 2010 Requirement of alpha- and beta-catenins for forskolin-induced stabilization of VE-cadherin on the actin bundles was confirmed by FRAP analyses using VEC-GFP mutants, supporting the classical model that alpha-catenin could potentially link the bundled actin to cadherin. Colforsin 44-53 cadherin 5 Homo sapiens 79-90 20080871-3 2010 Immunohistochemistry and Western blot experiments in 4B cells revealed time-dependent nuclear translocation of TORC1,TORC 2, and TORC3 by forskolin [but not by the phorbol ester, phorbol 12-myristate 13-acetate (PMA)] in a concentration-dependent manner. Colforsin 138-147 CREB regulated transcription coactivator 3 Homo sapiens 129-134 20080871-4 2010 In reporter gene assays, cotransfection of TORC1 or TORC2 potentiated the stimulatory effect of forskolin on CRH promoter activity but had no effect in cells treated with PMA. Colforsin 96-105 CREB regulated transcription coactivator 1 Homo sapiens 43-48 20080871-4 2010 In reporter gene assays, cotransfection of TORC1 or TORC2 potentiated the stimulatory effect of forskolin on CRH promoter activity but had no effect in cells treated with PMA. Colforsin 96-105 CREB regulated transcription coactivator 2 Homo sapiens 52-57 20080871-4 2010 In reporter gene assays, cotransfection of TORC1 or TORC2 potentiated the stimulatory effect of forskolin on CRH promoter activity but had no effect in cells treated with PMA. Colforsin 96-105 corticotropin releasing hormone Homo sapiens 109-112 20080871-5 2010 Knockout of endogenous TORC using silencing RNA markedly inhibited forskolin-activated CRH promoter activity in 4B cells, as well as the induction of endogenous CRH primary transcript by forskolin in primary neuronal cultures. Colforsin 67-76 corticotropin releasing hormone Homo sapiens 87-90 20080871-5 2010 Knockout of endogenous TORC using silencing RNA markedly inhibited forskolin-activated CRH promoter activity in 4B cells, as well as the induction of endogenous CRH primary transcript by forskolin in primary neuronal cultures. Colforsin 187-196 corticotropin releasing hormone Homo sapiens 161-164 20225391-5 2010 RESULTS: In FRT cells, apical chloride current induced by forskolin, CPT-cAMP and apigenin were reversibly inhibited by PDG (IC50 approximately 10microM) without effects on intracellular cAMP content and cell viability. Colforsin 58-67 phosphoglycerate dehydrogenase Homo sapiens 120-123 20225391-6 2010 Similarly, in T84 cells, PDG effectively inhibited chloride secretion induced by forskolin and cholera toxin. Colforsin 81-90 phosphoglycerate dehydrogenase Homo sapiens 25-28 20535929-6 2010 (2) As compared with the control, FSHR mRNA expression increased in cultured granulosa cells after treated by ZGY extract; the increasing effect of ZGY was enhanced by combined treatment with Forskolin and attenuated by Genistein (a tyrosine protein kinase inhibitor). Colforsin 192-201 follicle stimulating hormone receptor Rattus norvegicus 34-38 20032304-4 2010 Forskolin induced circumferential actin bundling and accumulation of VE-cadherin fused with green fluorescence protein (VEC-GFP) on the bundled actin filaments. Colforsin 0-9 cadherin 5 Homo sapiens 69-80 20032304-5 2010 Fluorescence recovery after photobleaching (FRAP) analyses using VEC-GFP revealed that forskolin stabilizes VE-cadherin at cell-cell contacts. Colforsin 87-96 cadherin 5 Homo sapiens 108-119 20032304-6 2010 These effects of forskolin were mimicked by an activator for Epac but not by that for protein kinase A. Colforsin 17-26 Rap guanine nucleotide exchange factor 3 Homo sapiens 61-65 21069159-7 2010 GLUT1 inhibitors Hg(II), cytochalasin B and forskolin reduced uptake of glucose but not CH3As(OH)2. Colforsin 44-53 solute carrier family 2 member 1 Homo sapiens 0-5 20003162-10 2010 Forskolin, an cAMP activator, could also suppress the expression of eotaxin-1 by IL-4 in a dose dependent manner (10(-7)-10(-10 )m). Colforsin 0-9 C-C motif chemokine ligand 11 Homo sapiens 68-77 20003162-10 2010 Forskolin, an cAMP activator, could also suppress the expression of eotaxin-1 by IL-4 in a dose dependent manner (10(-7)-10(-10 )m). Colforsin 0-9 interleukin 4 Homo sapiens 81-85 20026202-6 2010 In both DT-40 3KO and HEK-293 cells transiently expressing P2X(4)R, forskolin treatment enhanced ATP-mediated signaling. Colforsin 68-77 purinergic receptor P2X 4 Homo sapiens 59-66 20100459-6 2010 Hsp90AB1 transcript and protein levels increased significantly during morphine treatment, and co-application of geldanamycin (0.1-10 nM) effectively suppressed the increase in forskolin-activated adenylate cyclase activation by 56%. Colforsin 176-185 heat shock protein 90 alpha family class B member 1 Homo sapiens 0-8 19917606-8 2010 Induction of PKA activity with forskolin reduced modification of VACM-1 protein by Nedd8. Colforsin 31-40 cullin 5 Rattus norvegicus 65-71 19917606-8 2010 Induction of PKA activity with forskolin reduced modification of VACM-1 protein by Nedd8. Colforsin 31-40 NEDD8 ubiquitin like modifier Rattus norvegicus 83-88 20063885-3 2010 Here we show that induction of GSTP protein and mRNA expression in rat primary hepatocytes by Ap was inhibited by forskolin and a variety of cAMP analogues. Colforsin 114-123 glutathione S-transferase pi 1 Rattus norvegicus 31-35 20063885-5 2010 In the presence of Ap, forskolin, or both, the expression of phospho-cAMP response element-binding protein (CREB) was increased. Colforsin 23-32 cAMP responsive element binding protein 1 Rattus norvegicus 61-106 20063885-5 2010 In the presence of Ap, forskolin, or both, the expression of phospho-cAMP response element-binding protein (CREB) was increased. Colforsin 23-32 cAMP responsive element binding protein 1 Rattus norvegicus 108-112 20063885-6 2010 Ap alone had no effect on inducible cAMP early repressor (ICER) mRNA expression; however, Ap played a potentiating role in forskolin-induced ICER mRNA expression. Colforsin 123-132 cAMP responsive element modulator Rattus norvegicus 141-145 20063885-7 2010 An EMSA and immunoprecipitation assay showed that ICER binding to cAMP-response element (CRE) was increased in cells cotreated with Ap and forskolin for 3 and 8 h. Taken together, these results suggest that ICER is likely to be involved in the suppression of Ap-induced GSTP expression caused by the increase of cAMP in rat primary hepatocytes. Colforsin 139-148 cAMP responsive element modulator Rattus norvegicus 50-54 20063885-7 2010 An EMSA and immunoprecipitation assay showed that ICER binding to cAMP-response element (CRE) was increased in cells cotreated with Ap and forskolin for 3 and 8 h. Taken together, these results suggest that ICER is likely to be involved in the suppression of Ap-induced GSTP expression caused by the increase of cAMP in rat primary hepatocytes. Colforsin 139-148 cAMP responsive element modulator Rattus norvegicus 207-211 20063885-7 2010 An EMSA and immunoprecipitation assay showed that ICER binding to cAMP-response element (CRE) was increased in cells cotreated with Ap and forskolin for 3 and 8 h. Taken together, these results suggest that ICER is likely to be involved in the suppression of Ap-induced GSTP expression caused by the increase of cAMP in rat primary hepatocytes. Colforsin 139-148 glutathione S-transferase pi 1 Rattus norvegicus 270-274 20026202-7 2010 Specific PKA inhibitors prevented the forskolin-induced enhancement of ATP-mediated inward currents in P2X(4)R expressing HEK-293 cells. Colforsin 38-47 purinergic receptor P2X 4 Homo sapiens 103-110 20022930-5 2010 A cAMP stimulant, forskolin, and 8-bromoadenosine-cAMP increased PEPCK and G6Pase mRNA expression in H4IIE rat hepatoma cells, and ER stress induced by tunicamycin or thapsigargin decreased the expression of these genes in forskolin or 8-bromoadenosine-cAMP-treated cells. Colforsin 18-27 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 65-70 20022930-5 2010 A cAMP stimulant, forskolin, and 8-bromoadenosine-cAMP increased PEPCK and G6Pase mRNA expression in H4IIE rat hepatoma cells, and ER stress induced by tunicamycin or thapsigargin decreased the expression of these genes in forskolin or 8-bromoadenosine-cAMP-treated cells. Colforsin 18-27 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 75-81 20022930-5 2010 A cAMP stimulant, forskolin, and 8-bromoadenosine-cAMP increased PEPCK and G6Pase mRNA expression in H4IIE rat hepatoma cells, and ER stress induced by tunicamycin or thapsigargin decreased the expression of these genes in forskolin or 8-bromoadenosine-cAMP-treated cells. Colforsin 223-232 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 65-70 20022930-5 2010 A cAMP stimulant, forskolin, and 8-bromoadenosine-cAMP increased PEPCK and G6Pase mRNA expression in H4IIE rat hepatoma cells, and ER stress induced by tunicamycin or thapsigargin decreased the expression of these genes in forskolin or 8-bromoadenosine-cAMP-treated cells. Colforsin 223-232 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 75-81 20022930-7 2010 Also, adenovirus-mediated overexpression of ATF6 in H4IIE cells decreased forskolin-stimulated PEPCK and G6Pase gene expression. Colforsin 74-83 activating transcription factor 6 Rattus norvegicus 44-48 20022930-7 2010 Also, adenovirus-mediated overexpression of ATF6 in H4IIE cells decreased forskolin-stimulated PEPCK and G6Pase gene expression. Colforsin 74-83 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 95-100 20022930-7 2010 Also, adenovirus-mediated overexpression of ATF6 in H4IIE cells decreased forskolin-stimulated PEPCK and G6Pase gene expression. Colforsin 74-83 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 105-111 20022930-9 2010 Transient transfection of ATF6 inhibited transactivation by CREB on the PEPCK and G6Pase promoters, and a gel shift assay showed that Ad-ATF6 inhibits forskolin-stimulated CREB DNA-binding activity. Colforsin 151-160 activating transcription factor 6 Rattus norvegicus 26-30 20022930-9 2010 Transient transfection of ATF6 inhibited transactivation by CREB on the PEPCK and G6Pase promoters, and a gel shift assay showed that Ad-ATF6 inhibits forskolin-stimulated CREB DNA-binding activity. Colforsin 151-160 cAMP responsive element binding protein 1 Rattus norvegicus 60-64 20022930-9 2010 Transient transfection of ATF6 inhibited transactivation by CREB on the PEPCK and G6Pase promoters, and a gel shift assay showed that Ad-ATF6 inhibits forskolin-stimulated CREB DNA-binding activity. Colforsin 151-160 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 72-77 20022930-9 2010 Transient transfection of ATF6 inhibited transactivation by CREB on the PEPCK and G6Pase promoters, and a gel shift assay showed that Ad-ATF6 inhibits forskolin-stimulated CREB DNA-binding activity. Colforsin 151-160 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 82-88 20022930-9 2010 Transient transfection of ATF6 inhibited transactivation by CREB on the PEPCK and G6Pase promoters, and a gel shift assay showed that Ad-ATF6 inhibits forskolin-stimulated CREB DNA-binding activity. Colforsin 151-160 activating transcription factor 6 Rattus norvegicus 137-141 20022930-9 2010 Transient transfection of ATF6 inhibited transactivation by CREB on the PEPCK and G6Pase promoters, and a gel shift assay showed that Ad-ATF6 inhibits forskolin-stimulated CREB DNA-binding activity. Colforsin 151-160 cAMP responsive element binding protein 1 Rattus norvegicus 172-176 19818767-7 2010 Addition of a specific inhibitor of CFTR (CFTR(inh)-172) to 16HBE14o- and CFBE41o-pCep4 cells resulted in a time-dependent increase in TEER, whereas stimulation of CFTR by IBMX and forskolin caused a decrease. Colforsin 181-190 CF transmembrane conductance regulator Homo sapiens 36-40 20015475-10 2010 Challenge of U87-MG cells with PGE(2), at concentrations that induced maximal CREB activation, or with forskolin inhibited extracellular signal-regulated kinase (ERK) phosphorylation. Colforsin 103-112 mitogen-activated protein kinase 1 Homo sapiens 123-160 19818767-7 2010 Addition of a specific inhibitor of CFTR (CFTR(inh)-172) to 16HBE14o- and CFBE41o-pCep4 cells resulted in a time-dependent increase in TEER, whereas stimulation of CFTR by IBMX and forskolin caused a decrease. Colforsin 181-190 CF transmembrane conductance regulator Homo sapiens 42-55 19818767-7 2010 Addition of a specific inhibitor of CFTR (CFTR(inh)-172) to 16HBE14o- and CFBE41o-pCep4 cells resulted in a time-dependent increase in TEER, whereas stimulation of CFTR by IBMX and forskolin caused a decrease. Colforsin 181-190 CF transmembrane conductance regulator Homo sapiens 42-46 19854260-7 2010 Screening different activators of basic intracellular second messenger systems for their influence on NT-3 synthesis revealed that forskolin (20 microM), dibutyryl cAMP (dBcAMP) (100 microM), as well as calcimycin (1 microM) (Ca(2+) ionophore A23187) and phorbol 12-myristate 13-acetate (TPA) (100 nM), markedly increased the cellular level of NT-3 protein. Colforsin 131-140 neurotrophin 3 Rattus norvegicus 102-106 19950202-6 2010 Forskolin, an adenylate cyclase activator, and dbcAMP also increased PLD1 mRNA, suggesting the cellular cAMP as the inducer of both adipocyte differentiation and PLD1 transcription. Colforsin 0-9 phospholipase D1 Mus musculus 69-73 19950202-6 2010 Forskolin, an adenylate cyclase activator, and dbcAMP also increased PLD1 mRNA, suggesting the cellular cAMP as the inducer of both adipocyte differentiation and PLD1 transcription. Colforsin 0-9 phospholipase D1 Mus musculus 162-166 20009084-5 2010 We demonstrated that, whereas a transient exposure of rat isolated, intact, preovulatory follicles to either LH or forskolin was sufficient to induce oocyte maturation and cumulus expansion, these LH-induced responses were only generated upon a prolonged activity of the EGFR. Colforsin 115-124 epidermal growth factor receptor Rattus norvegicus 271-275 20015475-12 2010 Inhibition of ERK by PGE(2) or by forskolin was rescued by treatment of cells with H-89 or by the dominant negative PKA construct. Colforsin 34-43 mitogen-activated protein kinase 1 Homo sapiens 14-17 20015475-13 2010 Moreover, PGE(2) or forskolin inhibited phosphorylation of Raf-1 phosphorylation at Ser-338. Colforsin 20-29 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 59-64 20015475-10 2010 Challenge of U87-MG cells with PGE(2), at concentrations that induced maximal CREB activation, or with forskolin inhibited extracellular signal-regulated kinase (ERK) phosphorylation. Colforsin 103-112 mitogen-activated protein kinase 1 Homo sapiens 162-165 19956903-5 2010 The effects of an inducer of syncytialisation (forskolin) on mTOR, eIF4E binding proteins (4EBPs) and ribosomal protein S6 kinases (S6Ks) in BeWo cells were also assessed. Colforsin 47-56 mechanistic target of rapamycin kinase Homo sapiens 61-65 20043876-8 2010 Ser824, located in the carboxy-terminal cytosolic tail of TRPV4, is also phosphorylated after activation of the PKA pathway by forskolin, albeit less potently. Colforsin 127-136 transient receptor potential cation channel subfamily V member 4 Homo sapiens 58-63 20511715-8 2010 Similarly, treatment with 5 muM forskolin enhanced DeltapH/min significantly only in akt2(+/+) mice and abolished the differences between the genotypes. Colforsin 32-41 thymoma viral proto-oncogene 2 Mus musculus 85-89 20036562-7 2010 The maximal functional effects in inhibition of forskolin-stimulated cAMP were measured, indicating that this class of click adducts varied from partial to full A(3)AR agonist compared to other widely used agonists. Colforsin 48-57 adenosine A3 receptor Homo sapiens 161-167 19887595-7 2010 Treatment of primary human myotubes with forskolin, a cAMP signaling pathway activator, resulted in an approximately 2.5-fold increase in NAMPT protein expression, whereas treatment with ionomycin had no effect. Colforsin 41-50 nicotinamide phosphoribosyltransferase Homo sapiens 138-143 19956903-7 2010 Semi-quantitative RT-PCR analysis revealed that in early stages of syncytialisation (50 microM forskolin for 48 h), the expression of mTOR and 4EBP was down-regulated when compared to unstimulated cells. Colforsin 95-104 mechanistic target of rapamycin kinase Homo sapiens 134-138 19956903-10 2010 These data validate BeWo cells as an experimental model to study the effects of forskolin-induced syncytialisation on mTOR signalling. Colforsin 80-89 mechanistic target of rapamycin kinase Homo sapiens 118-122 21472212-8 2010 In addition, Forskolin-induced growth suppression was associated with the down-regulation of C-Myc. Colforsin 13-22 MYC proto-oncogene, bHLH transcription factor Homo sapiens 93-98 20038525-0 2010 Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion. Colforsin 57-66 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-5 20038525-3 2010 Therefore, we tested whether both PKA and Epac are involved in forskolin (FSK)/cAMP-stimulated Cl- secretion. Colforsin 63-72 Rap guanine nucleotide exchange factor 3 Homo sapiens 42-46 20038525-8 2010 In contrast, T84 cells with silenced Epac1 had a reduced I(sc) response to FSK, and this response was completely inhibited by H89, but not by the phospholipase C inhibitor U73122 or BAPTA-AM. Colforsin 75-78 Rap guanine nucleotide exchange factor 3 Homo sapiens 37-42 19883758-9 2010 The ERE-mediated ligand-independent ER activity was induced by the growth factors and forskolin in the somatolactotroph tumor cell line GH4C1 cells. Colforsin 86-95 estrogen receptor 1 Rattus norvegicus 4-6 19897601-3 2010 We also explored mechanisms underlying the ability of retinoic acid, dexamethasone, and the protein kinase A activator forskolin to induce VDR up-regulation as well. Colforsin 119-128 vitamin D receptor Homo sapiens 139-142 19897601-10 2010 These regulatory activities of 1,25(OH)(2)D(3), forskolin, and dexamethasone were recapitulated in MC3T3-E1 cells stably transfected with a full-length VDR bacterial artificial chromosome (BAC) clone-luciferase reporter gene. Colforsin 48-57 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 152-155 19841070-4 2010 Forskolin and [desamino-Cys(1), D-Arg(8)]-vasopressin (DDAVP)-induced AQP2 exocytosis was impaired in VAMP8-null collecting duct cells. Colforsin 0-9 aquaporin 2 Mus musculus 70-74 19841070-4 2010 Forskolin and [desamino-Cys(1), D-Arg(8)]-vasopressin (DDAVP)-induced AQP2 exocytosis was impaired in VAMP8-null collecting duct cells. Colforsin 0-9 vesicle-associated membrane protein 8 Mus musculus 102-107 19850014-5 2009 Both forskolin and 3-isobutyl-1-methylxanthine (IBMX), which may finally elevate cyclic adenosine monophosphate (cAMP) concentration, prevented the induction of adiponectin expression by Ex-4. Colforsin 5-14 adiponectin, C1Q and collagen domain containing Homo sapiens 161-172 19573542-6 2010 In contrast, the process is suggested to be driven by cAMP since treatment of AtT20 cells with forskolin triggered strong ERK phosphorylation. Colforsin 95-104 mitogen-activated protein kinase 1 Mus musculus 122-125 19573542-11 2010 Knockdown of EPAC2 expression by the use of specific siRNAs abolished CRF- and forskolin-induced ERK phosphorylation. Colforsin 79-88 Rap guanine nucleotide exchange factor (GEF) 4 Mus musculus 13-18 19573542-11 2010 Knockdown of EPAC2 expression by the use of specific siRNAs abolished CRF- and forskolin-induced ERK phosphorylation. Colforsin 79-88 mitogen-activated protein kinase 1 Mus musculus 97-100 19959669-6 2009 We also found that a selective cAMP-degrading phosphodiesterase (PDE) 4 inhibitor can potentiate the chemokine expression elicited by low-dose forskolin or Prostaglandin E2 (PGE(2)). Colforsin 143-152 phosphodiesterase 4A Homo sapiens 65-71 19822197-3 2009 MEHP was found to significantly suppress Forskolin (FSK)-induced CYP19 gene transcription, CYP19 promoter II activity and CYP19 enzyme activity in a dose-dependent manner. Colforsin 41-50 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 65-70 19822197-3 2009 MEHP was found to significantly suppress Forskolin (FSK)-induced CYP19 gene transcription, CYP19 promoter II activity and CYP19 enzyme activity in a dose-dependent manner. Colforsin 41-50 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 91-96 19822197-3 2009 MEHP was found to significantly suppress Forskolin (FSK)-induced CYP19 gene transcription, CYP19 promoter II activity and CYP19 enzyme activity in a dose-dependent manner. Colforsin 41-50 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 91-96 19822197-3 2009 MEHP was found to significantly suppress Forskolin (FSK)-induced CYP19 gene transcription, CYP19 promoter II activity and CYP19 enzyme activity in a dose-dependent manner. Colforsin 52-55 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 65-70 19822197-3 2009 MEHP was found to significantly suppress Forskolin (FSK)-induced CYP19 gene transcription, CYP19 promoter II activity and CYP19 enzyme activity in a dose-dependent manner. Colforsin 52-55 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 91-96 19822197-3 2009 MEHP was found to significantly suppress Forskolin (FSK)-induced CYP19 gene transcription, CYP19 promoter II activity and CYP19 enzyme activity in a dose-dependent manner. Colforsin 52-55 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 91-96 19852935-7 2009 As a result, forskolin/IBMX treatment triggered a current (I(cAMP)) in CFTR-expressing Xenopus oocytes, but not in oocytes expressing (DeltaF508)CFTR. Colforsin 13-22 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 71-75 19853581-6 2009 Besides, the CaM promoter activity could be upregulated by IGF but suppressed by PACAP, forskolin and over-expression of Sp1 and Sp3. Colforsin 88-97 calmodulin 3 Homo sapiens 13-16 19794145-6 2009 Forskolin increased only the apical localization of AQP2, which was not affected by basolateral treatment with 0.5% tannic acid, indicating that the forskolin-induced apical transport of AQP2 did not include the transcytotic pathway from basolateral to apical membranes but is a direct transport from TGN to the apical membranes. Colforsin 0-9 aquaporin 2 Canis lupus familiaris 52-56 19922557-9 2009 RESULTS: Carbamazepine preferentially inhibited forskolin-stimulated AC5 and AC1 and all D1 agonist-stimulated ACs, with AC5 and AC7 being the most sensitive. Colforsin 48-57 adenylate cyclase 5 Mus musculus 69-72 19922557-9 2009 RESULTS: Carbamazepine preferentially inhibited forskolin-stimulated AC5 and AC1 and all D1 agonist-stimulated ACs, with AC5 and AC7 being the most sensitive. Colforsin 48-57 adenylate cyclase 1 Mus musculus 77-80 19779011-5 2009 Accordingly, in isolated colonic crypts pretreated with forskolin and carbachol for 10 min, respectively, and subjected to immunohistochemistry, the NBCe1 signal showed a markedly stronger colocalization with the E-cadherin signal, which was used as a membrane marker, compared with the untreated control. Colforsin 56-65 cadherin 1 Mus musculus 213-223 19833152-5 2009 Forskolin increased the phosphorylation of Ser40 in hTH1 and Ser44 in hTH2. Colforsin 0-9 negative elongation factor complex member C/D Homo sapiens 52-56 19543827-2 2009 To determine whether endogenous ICER production represses CRH transcription, we examined the effect of CREM siRNA on forskolin-stimulated ICER formation and CRH transcription in the hypothalamic cell line, 4B, and in primary cultures of hypothalamic neurons. Colforsin 117-126 cAMP responsive element modulator Homo sapiens 103-107 19794145-6 2009 Forskolin increased only the apical localization of AQP2, which was not affected by basolateral treatment with 0.5% tannic acid, indicating that the forskolin-induced apical transport of AQP2 did not include the transcytotic pathway from basolateral to apical membranes but is a direct transport from TGN to the apical membranes. Colforsin 149-158 aquaporin 2 Canis lupus familiaris 52-56 19543827-2 2009 To determine whether endogenous ICER production represses CRH transcription, we examined the effect of CREM siRNA on forskolin-stimulated ICER formation and CRH transcription in the hypothalamic cell line, 4B, and in primary cultures of hypothalamic neurons. Colforsin 117-126 cAMP responsive element modulator Homo sapiens 138-142 19543827-3 2009 Cotransfection of 4B cells with CREM siRNA and a CRH promoter-driven luciferase reporter gene markedly reduced the induction of ICER by forskolin and potentiated the stimulatory effect of forskolin on CRH promoter activity, compared with cells cotransfected with a nonspecific oligonucleotide. Colforsin 136-145 cAMP responsive element modulator Homo sapiens 32-36 19794145-6 2009 Forskolin increased only the apical localization of AQP2, which was not affected by basolateral treatment with 0.5% tannic acid, indicating that the forskolin-induced apical transport of AQP2 did not include the transcytotic pathway from basolateral to apical membranes but is a direct transport from TGN to the apical membranes. Colforsin 149-158 aquaporin 2 Canis lupus familiaris 187-191 19543827-3 2009 Cotransfection of 4B cells with CREM siRNA and a CRH promoter-driven luciferase reporter gene markedly reduced the induction of ICER by forskolin and potentiated the stimulatory effect of forskolin on CRH promoter activity, compared with cells cotransfected with a nonspecific oligonucleotide. Colforsin 136-145 corticotropin releasing hormone Homo sapiens 49-52 19794145-7 2009 Using these cell lines, we tested the effect of FAPP2 knockdown on the polarized AQP2 transport to plasma membranes and found that the forskolin-induced apical transport of AQP2 was completely abolished by FAPP2 knockdown. Colforsin 135-144 pleckstrin homology domain containing A8 Canis lupus familiaris 48-53 19543827-3 2009 Cotransfection of 4B cells with CREM siRNA and a CRH promoter-driven luciferase reporter gene markedly reduced the induction of ICER by forskolin and potentiated the stimulatory effect of forskolin on CRH promoter activity, compared with cells cotransfected with a nonspecific oligonucleotide. Colforsin 136-145 cAMP responsive element modulator Homo sapiens 128-132 19543827-3 2009 Cotransfection of 4B cells with CREM siRNA and a CRH promoter-driven luciferase reporter gene markedly reduced the induction of ICER by forskolin and potentiated the stimulatory effect of forskolin on CRH promoter activity, compared with cells cotransfected with a nonspecific oligonucleotide. Colforsin 188-197 cAMP responsive element modulator Homo sapiens 32-36 19543827-3 2009 Cotransfection of 4B cells with CREM siRNA and a CRH promoter-driven luciferase reporter gene markedly reduced the induction of ICER by forskolin and potentiated the stimulatory effect of forskolin on CRH promoter activity, compared with cells cotransfected with a nonspecific oligonucleotide. Colforsin 188-197 corticotropin releasing hormone Homo sapiens 49-52 19543827-3 2009 Cotransfection of 4B cells with CREM siRNA and a CRH promoter-driven luciferase reporter gene markedly reduced the induction of ICER by forskolin and potentiated the stimulatory effect of forskolin on CRH promoter activity, compared with cells cotransfected with a nonspecific oligonucleotide. Colforsin 188-197 corticotropin releasing hormone Homo sapiens 201-204 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 35-44 corticotropin releasing hormone Homo sapiens 56-59 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 35-44 cAMP responsive element modulator Homo sapiens 164-168 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 35-44 cAMP responsive element modulator Homo sapiens 201-205 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 35-44 corticotropin releasing hormone Homo sapiens 276-279 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 35-44 cAMP responsive element modulator Homo sapiens 347-351 19794145-7 2009 Using these cell lines, we tested the effect of FAPP2 knockdown on the polarized AQP2 transport to plasma membranes and found that the forskolin-induced apical transport of AQP2 was completely abolished by FAPP2 knockdown. Colforsin 135-144 aquaporin 2 Canis lupus familiaris 81-85 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 35-44 corticotropin releasing hormone Homo sapiens 276-279 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 35-44 cAMP responsive element modulator Homo sapiens 347-351 19794145-7 2009 Using these cell lines, we tested the effect of FAPP2 knockdown on the polarized AQP2 transport to plasma membranes and found that the forskolin-induced apical transport of AQP2 was completely abolished by FAPP2 knockdown. Colforsin 135-144 aquaporin 2 Canis lupus familiaris 173-177 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 35-44 corticotropin releasing hormone Homo sapiens 276-279 19794145-7 2009 Using these cell lines, we tested the effect of FAPP2 knockdown on the polarized AQP2 transport to plasma membranes and found that the forskolin-induced apical transport of AQP2 was completely abolished by FAPP2 knockdown. Colforsin 135-144 pleckstrin homology domain containing A8 Canis lupus familiaris 206-211 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 183-192 corticotropin releasing hormone Homo sapiens 56-59 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 183-192 cAMP responsive element modulator Homo sapiens 164-168 19794145-9 2009 AQP2 phosphorylation by forskolin was also impaired in FAPP2 knockdown MDCK cells. Colforsin 24-33 aquaporin 2 Canis lupus familiaris 0-4 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 183-192 cAMP responsive element modulator Homo sapiens 201-205 19794145-9 2009 AQP2 phosphorylation by forskolin was also impaired in FAPP2 knockdown MDCK cells. Colforsin 24-33 pleckstrin homology domain containing A8 Canis lupus familiaris 55-60 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 183-192 corticotropin releasing hormone Homo sapiens 276-279 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 183-192 cAMP responsive element modulator Homo sapiens 347-351 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 183-192 corticotropin releasing hormone Homo sapiens 276-279 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 183-192 cAMP responsive element modulator Homo sapiens 347-351 19543827-5 2009 As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress. Colforsin 183-192 corticotropin releasing hormone Homo sapiens 276-279 19733667-6 2009 Forskolin and okadaic acid induced sustained VASP phosphorylation at a high level, causing a significant reduction of the retraction of membrane ruffles and chemotaxis. Colforsin 0-9 vasodilator stimulated phosphoprotein Homo sapiens 45-49 19920112-13 2009 Forskolin activation of PKA also produced significant protection against trastuzumab-mediated Akt dephosphorylation. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 94-97 19720788-7 2009 RESULTS: Exendin-4 and forskolin protected beta-cells against FFAs via the induction of the ER chaperone BiP and the antiapoptotic protein JunB that mediate beta-cell survival under lipotoxic conditions. Colforsin 23-32 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 105-108 19720788-7 2009 RESULTS: Exendin-4 and forskolin protected beta-cells against FFAs via the induction of the ER chaperone BiP and the antiapoptotic protein JunB that mediate beta-cell survival under lipotoxic conditions. Colforsin 23-32 JunB proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 139-143 19720788-8 2009 On the other hand, exendin-4 and forskolin protected against synthetic ER stressors by inactivating caspase 12 and upregulating Bcl-2 and X-chromosome-linked inhibitor of apoptosis protein that inhibit mitochondrial apoptosis. Colforsin 33-42 caspase 12 Rattus norvegicus 100-110 19720788-8 2009 On the other hand, exendin-4 and forskolin protected against synthetic ER stressors by inactivating caspase 12 and upregulating Bcl-2 and X-chromosome-linked inhibitor of apoptosis protein that inhibit mitochondrial apoptosis. Colforsin 33-42 BCL2, apoptosis regulator Rattus norvegicus 128-133 19749080-8 2009 Subsequent studies showed that NECA and forskolin decreased LPS-induced steady-state TNF-alpha mRNA levels; this effect was due to a decreased rate of transcription based on assays examining the rate of generation of primary TNF-alpha transcripts. Colforsin 40-49 tumor necrosis factor Mus musculus 85-94 19749080-8 2009 Subsequent studies showed that NECA and forskolin decreased LPS-induced steady-state TNF-alpha mRNA levels; this effect was due to a decreased rate of transcription based on assays examining the rate of generation of primary TNF-alpha transcripts. Colforsin 40-49 tumor necrosis factor Mus musculus 225-234 19733667-7 2009 In forskolin- or okadaic acid-treated cells, phosphorylated VASP remained at the membrane cortex, and size and number of mature focal adhesions were not increased, indicating that prolonged phosphorylation of VASP could inhibit transformation of focal complexes into focal adhesions. Colforsin 3-12 vasodilator stimulated phosphoprotein Homo sapiens 60-64 19733667-7 2009 In forskolin- or okadaic acid-treated cells, phosphorylated VASP remained at the membrane cortex, and size and number of mature focal adhesions were not increased, indicating that prolonged phosphorylation of VASP could inhibit transformation of focal complexes into focal adhesions. Colforsin 3-12 vasodilator stimulated phosphoprotein Homo sapiens 209-213 19850345-8 2009 To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP. Colforsin 95-104 cathelicidin antimicrobial peptide Homo sapiens 79-83 19741007-4 2009 In receptor-expressing cells and brain slices, activation of both 5-HT1AR and 5-HT1BR reduced forskolin-stimulated cAMP production, but only the effect of 5-HT1BR was abolished by selective GSK3 inhibitors, deletion of GSK3beta by RNAi, or overexpression of impaired GSK3beta mutants (R96A and K85,86A). Colforsin 94-103 glycogen synthase kinase 3 beta Homo sapiens 219-227 19741007-4 2009 In receptor-expressing cells and brain slices, activation of both 5-HT1AR and 5-HT1BR reduced forskolin-stimulated cAMP production, but only the effect of 5-HT1BR was abolished by selective GSK3 inhibitors, deletion of GSK3beta by RNAi, or overexpression of impaired GSK3beta mutants (R96A and K85,86A). Colforsin 94-103 glycogen synthase kinase 3 beta Homo sapiens 267-275 19850345-8 2009 To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP. Colforsin 95-104 cathelicidin antimicrobial peptide Homo sapiens 157-161 19850345-8 2009 To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP. Colforsin 95-104 interleukin 1 beta Homo sapiens 200-208 19880655-10 2009 Finally, mRLD6 was also a target for forskolin-induced cellular response element-binding protein (CREB) recruitment, which potentiated cytokine activity. Colforsin 37-46 cAMP responsive element binding protein 1 Mus musculus 98-102 19850345-8 2009 To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP. Colforsin 95-104 tumor necrosis factor Homo sapiens 213-222 19850345-8 2009 To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP. Colforsin 95-104 interleukin 6 Homo sapiens 232-236 19850345-8 2009 To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP. Colforsin 95-104 cathelicidin antimicrobial peptide Homo sapiens 157-161 19850345-8 2009 To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP. Colforsin 95-104 cathelicidin antimicrobial peptide Homo sapiens 157-161 19692500-5 2009 Forskolin is an activator of adenylate cyclase, which increased CD9 and ERVWE1 expression. Colforsin 0-9 CD9 molecule Homo sapiens 64-67 19692500-5 2009 Forskolin is an activator of adenylate cyclase, which increased CD9 and ERVWE1 expression. Colforsin 0-9 endogenous retrovirus group W member 1, envelope Homo sapiens 72-78 19939245-7 2009 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin 145-154 transcription factor AP-2 alpha Homo sapiens 75-85 19967152-4 2009 Stimulation of the cells with forskolin and dibutyryl cyclic AMP (DBcAMP) increased TAFI antigen levels in the cells in parallel with TAFI mRNA levels and antigen release from the cells into the conditioned medium. Colforsin 30-39 carboxypeptidase B2 Homo sapiens 84-88 19967152-4 2009 Stimulation of the cells with forskolin and dibutyryl cyclic AMP (DBcAMP) increased TAFI antigen levels in the cells in parallel with TAFI mRNA levels and antigen release from the cells into the conditioned medium. Colforsin 30-39 carboxypeptidase B2 Homo sapiens 134-138 19939245-7 2009 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin 227-236 ETS proto-oncogene 2, transcription factor Homo sapiens 22-27 19939245-3 2009 METHODS: The effect of Forskolin (PKA) on MMP-2 expression was assessed by Northern Blot and RT-PCR. Colforsin 23-32 matrix metallopeptidase 2 Homo sapiens 42-47 19939245-4 2009 Possible transcription factors binding to consensus MMP-2 promoter sequences in response to Forskolin, were detected by EMSA binding assay and their expression assessed by western blot analysis. Colforsin 92-101 matrix metallopeptidase 2 Homo sapiens 52-57 19939245-7 2009 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin 227-236 tumor protein p53 Homo sapiens 38-41 19939245-6 2009 RESULTS: We found that Forskolin increased MMP-2 mRNA in JAR cells within 24 hours, and induced binding to p53, Ets, C/EBP and AP-2. Colforsin 23-32 matrix metallopeptidase 2 Homo sapiens 43-48 19939245-7 2009 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin 227-236 CCAAT enhancer binding protein epsilon Homo sapiens 43-56 19939245-6 2009 RESULTS: We found that Forskolin increased MMP-2 mRNA in JAR cells within 24 hours, and induced binding to p53, Ets, C/EBP and AP-2. Colforsin 23-32 tumor protein p53 Homo sapiens 107-110 19939245-6 2009 RESULTS: We found that Forskolin increased MMP-2 mRNA in JAR cells within 24 hours, and induced binding to p53, Ets, C/EBP and AP-2. Colforsin 23-32 CCAAT enhancer binding protein alpha Homo sapiens 117-122 19939245-6 2009 RESULTS: We found that Forskolin increased MMP-2 mRNA in JAR cells within 24 hours, and induced binding to p53, Ets, C/EBP and AP-2. Colforsin 23-32 transcription factor AP-2 alpha Homo sapiens 127-131 19939245-7 2009 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin 227-236 CCAAT enhancer binding protein alpha Homo sapiens 43-48 19939245-7 2009 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin 145-154 ETS proto-oncogene 2, transcription factor Homo sapiens 22-27 19939245-7 2009 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin 145-154 tumor protein p53 Homo sapiens 38-41 19939245-7 2009 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin 227-236 transcription factor AP-2 alpha Homo sapiens 75-85 19939245-7 2009 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin 145-154 CCAAT enhancer binding protein epsilon Homo sapiens 43-56 19939245-8 2009 Inhibition of Ets-2 and p53 reduced MMP-2 expression, secretion and invasiveness of Forskolin treated cells. Colforsin 84-93 ETS proto-oncogene 2, transcription factor Homo sapiens 14-19 19939245-7 2009 Transcription factors Ets-2, phospho- p53, C/EBP epsilon, C/EBP lambda and AP-2 alpha bound to their respective binding sequences in response to Forskolin and the expressions of these transcription factors were all elevated in Forskolin- treated cells. Colforsin 145-154 CCAAT enhancer binding protein alpha Homo sapiens 43-48 19939245-8 2009 Inhibition of Ets-2 and p53 reduced MMP-2 expression, secretion and invasiveness of Forskolin treated cells. Colforsin 84-93 tumor protein p53 Homo sapiens 24-27 19939245-8 2009 Inhibition of Ets-2 and p53 reduced MMP-2 expression, secretion and invasiveness of Forskolin treated cells. Colforsin 84-93 matrix metallopeptidase 2 Homo sapiens 36-41 19748893-6 2009 Forskolin, which like AlF(4)(-) activates adenylate cyclase, did not redistribute perilipin 3, but when added together with AlF(4)(-) perilipin 3 was recruited to lipid droplets rather than the ER. Colforsin 0-9 perilipin 3 Homo sapiens 134-145 19703466-3 2009 For example, mutant Galpha(i1)-T329A shows an 18-fold increase in basal GDP release rate and, when expressed in culture, it causes a significant decrease in forskolin-stimulated cAMP accumulation. Colforsin 157-166 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 20-29 19748893-7 2009 Thus inhibiting trafficking with AlF(4)(-) redistributed perilipin 3 differently under conditions of triacylglycerol synthesis (fatty acid addition) versus hydrolysis (forskolin) suggesting a shared acylglycerol-mediated mechanism. Colforsin 168-177 perilipin 3 Homo sapiens 57-68 19598075-0 2009 Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1). Colforsin 70-79 insulin 1 Rattus norvegicus 172-177 19788494-0 2009 Differential activation of the HCO(3)(-) conductance through the cystic fibrosis transmembrane conductance regulator anion channel by genistein and forskolin in murine duodenum. Colforsin 148-157 cystic fibrosis transmembrane conductance regulator Mus musculus 65-116 19880730-5 2009 Because luzindole and 4P-PDOT inhibited MT-induced luminescence, the action of this hormone is likely to be mediated through binding to the MT2 receptor subtype, which probably decreases the intracellular concentration of cyclic AMP (cAMP) because forskolin (a cAMP donor) strongly inhibits the light response to MT. Colforsin 248-257 metallothionein 2A Homo sapiens 140-143 19948481-6 2009 Acute perturbation of adipocyte differentiation with PPARgamma agonists, forskolin, and fatty acids induced subpopulation-specific effects, including redistribution of the percentage of cells in observed subpopulations and differential expression levels of PPARgamma. Colforsin 73-82 peroxisome proliferator activated receptor gamma Homo sapiens 257-266 19734360-4 2009 Forskolin and the cAMP analog 8-(4-chlorophenylthio)-cAMP promote a similar pattern of VASP phosphorylation at both sites. Colforsin 0-9 vasodilator-stimulated phosphoprotein Mus musculus 87-91 19788494-9 2009 CONCLUSIONS AND IMPLICATIONS: Genistein stimulates duodenal HCO(3)(-) and Cl(-) secretion through CFTR, and has a relatively high selectivity for the CFTR HCO(3)(-) conductance, compared with forskolin. Colforsin 192-201 cystic fibrosis transmembrane conductance regulator Mus musculus 150-154 19505977-5 2009 PTH (1-34) and PTH (1-31) inhibited Osx mRNA and protein expression, and this effect could be mimicked by forskolin, 8-bromo-cAMP, or expression of constitutively active Gsalpha (caGsalpha). Colforsin 106-115 parathyroid hormone Rattus norvegicus 0-3 19505977-5 2009 PTH (1-34) and PTH (1-31) inhibited Osx mRNA and protein expression, and this effect could be mimicked by forskolin, 8-bromo-cAMP, or expression of constitutively active Gsalpha (caGsalpha). Colforsin 106-115 parathyroid hormone Rattus norvegicus 15-18 19505977-5 2009 PTH (1-34) and PTH (1-31) inhibited Osx mRNA and protein expression, and this effect could be mimicked by forskolin, 8-bromo-cAMP, or expression of constitutively active Gsalpha (caGsalpha). Colforsin 106-115 Sp7 transcription factor Rattus norvegicus 36-39 19598075-5 2009 Acute melatonin treatment (6 h) in the presence of either forskolin or 3-isobutyl-1-methylxanthine caused a significant decrease in insulin release and induced significant downregulation of calcium/calmodulin-dependent kinase IV and calcium/calmodulin-dependent kinase 2d transcripts in INS-1 batch cultures. Colforsin 58-67 insulin 1 Rattus norvegicus 287-292 19696145-8 2009 Furthermore, forskolin- and aluminum tetrafluoride-stimulated adenylyl cyclase activity was significantly increased by caveolin knockdown in cells or in brain membranes obtained from caveolin-1 knockout mice, indicating that caveolin attenuates signaling at the level of Galpha(s)/adenylyl cyclase and distal to GPCRs. Colforsin 13-22 caveolin 1, caveolae protein Mus musculus 183-193 19667072-5 2009 Forskolin treatment induced 14-3-3 binding to Lfc and suppressed the exchange activity of wild-type Lfc on RhoA. Colforsin 0-9 ras homolog family member A Homo sapiens 107-111 19665003-1 2009 In this study, we investigated the effects of statins, fibrates, 9-cis-retinoic acid and forskolin on the transcription of the mitochondrial carnitine/acylcarnitine carrier (CAC) gene. Colforsin 89-98 solute carrier family 25 member 20 Homo sapiens 127-178 19720729-7 2009 Expression of dominant-negative Ras inhibited ERK activation by TSH, forskolin, and N(6)-monobutyryl (6MB)-cAMP, a selective activator of PKA. Colforsin 69-78 Eph receptor B1 Rattus norvegicus 46-49 19720729-8 2009 Silencing the expression of B-Raf also inhibited ERK activation by TSH, forskolin, and 6MB-cAMP, but not that stimulated by insulin or serum. Colforsin 72-81 B-Raf proto-oncogene, serine/threonine kinase Rattus norvegicus 28-33 19720729-8 2009 Silencing the expression of B-Raf also inhibited ERK activation by TSH, forskolin, and 6MB-cAMP, but not that stimulated by insulin or serum. Colforsin 72-81 Eph receptor B1 Rattus norvegicus 49-52 19700529-4 2009 Western analysis showed that germinal vesicle (GV)-stage oocytes after forskolin pulsing contained increased levels of phospho-acetyl CoA carboxylase (pACACA), a primary substrate of PRKA. Colforsin 71-80 A kinase (PRKA) anchor protein 6 Mus musculus 183-187 19704004-2 2009 We demonstrate that PTHrP or forskolin administration can block induction of collagen X-luciferase by exogenous Runx2, MEF2, and Smad1 in transfected chondrocytes. Colforsin 29-38 RUNX family transcription factor 2 Homo sapiens 112-117 19704004-2 2009 We demonstrate that PTHrP or forskolin administration can block induction of collagen X-luciferase by exogenous Runx2, MEF2, and Smad1 in transfected chondrocytes. Colforsin 29-38 myocyte enhancer factor 2A Homo sapiens 119-123 19704004-2 2009 We demonstrate that PTHrP or forskolin administration can block induction of collagen X-luciferase by exogenous Runx2, MEF2, and Smad1 in transfected chondrocytes. Colforsin 29-38 SMAD family member 1 Homo sapiens 129-134 19704004-3 2009 We have found that PTHrP/forskolin administration represses the transcriptional activity of MEF2 and that forced expression of MEF2-VP16 can restore expression of the collagen X reporter in chondrocytes treated with these agents. Colforsin 25-34 myocyte enhancer factor 2A Homo sapiens 92-96 19704004-4 2009 PTHrP/forskolin induces dephosphorylation of histone deacetylase 4 (HDAC4) phospho-S246, which decreases interaction of HDAC4 with cytoplasmic 14-3-3 proteins and promotes nuclear translocation of HDAC4 and repression of MEF2 transcriptional activity. Colforsin 6-15 parathyroid hormone like hormone Homo sapiens 0-5 19704004-4 2009 PTHrP/forskolin induces dephosphorylation of histone deacetylase 4 (HDAC4) phospho-S246, which decreases interaction of HDAC4 with cytoplasmic 14-3-3 proteins and promotes nuclear translocation of HDAC4 and repression of MEF2 transcriptional activity. Colforsin 6-15 histone deacetylase 4 Homo sapiens 45-66 19704004-4 2009 PTHrP/forskolin induces dephosphorylation of histone deacetylase 4 (HDAC4) phospho-S246, which decreases interaction of HDAC4 with cytoplasmic 14-3-3 proteins and promotes nuclear translocation of HDAC4 and repression of MEF2 transcriptional activity. Colforsin 6-15 histone deacetylase 4 Homo sapiens 68-73 19704004-4 2009 PTHrP/forskolin induces dephosphorylation of histone deacetylase 4 (HDAC4) phospho-S246, which decreases interaction of HDAC4 with cytoplasmic 14-3-3 proteins and promotes nuclear translocation of HDAC4 and repression of MEF2 transcriptional activity. Colforsin 6-15 histone deacetylase 4 Homo sapiens 120-125 19704004-4 2009 PTHrP/forskolin induces dephosphorylation of histone deacetylase 4 (HDAC4) phospho-S246, which decreases interaction of HDAC4 with cytoplasmic 14-3-3 proteins and promotes nuclear translocation of HDAC4 and repression of MEF2 transcriptional activity. Colforsin 6-15 histone deacetylase 4 Homo sapiens 120-125 19704004-4 2009 PTHrP/forskolin induces dephosphorylation of histone deacetylase 4 (HDAC4) phospho-S246, which decreases interaction of HDAC4 with cytoplasmic 14-3-3 proteins and promotes nuclear translocation of HDAC4 and repression of MEF2 transcriptional activity. Colforsin 6-15 myocyte enhancer factor 2A Homo sapiens 221-225 19704004-5 2009 We have found that forskolin increases the activity of an HDAC4 phospho-S246 phosphatase and that forskolin-induced nuclear translocation of HDAC4 was reversed by the protein phosphatase 2A (PP2A) antagonist, okadaic acid. Colforsin 19-28 histone deacetylase 4 Homo sapiens 58-63 19704004-5 2009 We have found that forskolin increases the activity of an HDAC4 phospho-S246 phosphatase and that forskolin-induced nuclear translocation of HDAC4 was reversed by the protein phosphatase 2A (PP2A) antagonist, okadaic acid. Colforsin 19-28 histone deacetylase 4 Homo sapiens 141-146 19704004-5 2009 We have found that forskolin increases the activity of an HDAC4 phospho-S246 phosphatase and that forskolin-induced nuclear translocation of HDAC4 was reversed by the protein phosphatase 2A (PP2A) antagonist, okadaic acid. Colforsin 19-28 protein phosphatase 2 phosphatase activator Homo sapiens 191-195 19704004-5 2009 We have found that forskolin increases the activity of an HDAC4 phospho-S246 phosphatase and that forskolin-induced nuclear translocation of HDAC4 was reversed by the protein phosphatase 2A (PP2A) antagonist, okadaic acid. Colforsin 98-107 histone deacetylase 4 Homo sapiens 141-146 19704004-5 2009 We have found that forskolin increases the activity of an HDAC4 phospho-S246 phosphatase and that forskolin-induced nuclear translocation of HDAC4 was reversed by the protein phosphatase 2A (PP2A) antagonist, okadaic acid. Colforsin 98-107 protein phosphatase 2 phosphatase activator Homo sapiens 191-195 19704004-6 2009 Finally, we demonstrate that knockdown of PP2A inhibits forskolin-induced nuclear translocation of HDAC4 and attenuates the ability of this signaling molecule to repress collagen X expression in chondrocytes, indicating that PP2A is critical for PTHrP-mediated regulation of chondrocyte hypertrophy. Colforsin 56-65 protein phosphatase 2 phosphatase activator Homo sapiens 42-46 19704004-6 2009 Finally, we demonstrate that knockdown of PP2A inhibits forskolin-induced nuclear translocation of HDAC4 and attenuates the ability of this signaling molecule to repress collagen X expression in chondrocytes, indicating that PP2A is critical for PTHrP-mediated regulation of chondrocyte hypertrophy. Colforsin 56-65 histone deacetylase 4 Homo sapiens 99-104 19704004-6 2009 Finally, we demonstrate that knockdown of PP2A inhibits forskolin-induced nuclear translocation of HDAC4 and attenuates the ability of this signaling molecule to repress collagen X expression in chondrocytes, indicating that PP2A is critical for PTHrP-mediated regulation of chondrocyte hypertrophy. Colforsin 56-65 protein phosphatase 2 phosphatase activator Homo sapiens 225-229 19704004-6 2009 Finally, we demonstrate that knockdown of PP2A inhibits forskolin-induced nuclear translocation of HDAC4 and attenuates the ability of this signaling molecule to repress collagen X expression in chondrocytes, indicating that PP2A is critical for PTHrP-mediated regulation of chondrocyte hypertrophy. Colforsin 56-65 parathyroid hormone like hormone Homo sapiens 246-251 19665003-2 2009 Statins, fibrates, retinoic acid and forskolin activate luciferase gene reporter activity driven by the -334/+3 bp region of the human CAC promoter containing wild-type (but not mutated) PPRE. Colforsin 37-46 solute carrier family 25 member 20 Homo sapiens 135-138 19665003-5 2009 Mevalonate abolishes the activation of CAC gene expression by statins; the inhibitor of the PKA pathway H89 suppresses the stimulation of CAC gene expression by forskolin. Colforsin 161-170 solute carrier family 25 member 20 Homo sapiens 138-141 19683536-0 2009 Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene. Colforsin 51-60 cyclin C Homo sapiens 81-89 19683536-4 2009 The Cyclin C gene also directly responds to the cAMP activator Forskolin via the transcription factor CREB1 (cAMP response element-binding protein 1), for which we identified four binding sites within the first 2250 bp of its promoter. Colforsin 63-72 cyclin C Homo sapiens 4-12 19683536-4 2009 The Cyclin C gene also directly responds to the cAMP activator Forskolin via the transcription factor CREB1 (cAMP response element-binding protein 1), for which we identified four binding sites within the first 2250 bp of its promoter. Colforsin 63-72 cAMP responsive element binding protein 1 Homo sapiens 102-107 19683536-4 2009 The Cyclin C gene also directly responds to the cAMP activator Forskolin via the transcription factor CREB1 (cAMP response element-binding protein 1), for which we identified four binding sites within the first 2250 bp of its promoter. Colforsin 63-72 cAMP responsive element binding protein 1 Homo sapiens 109-148 19683536-8 2009 This suggests that the primary regulation of Cyclin C by all-trans RA and Forskolin mediates some of the cell cycle control actions of these compounds. Colforsin 74-83 cyclin C Homo sapiens 45-53 19651776-7 2009 Adenovirus-mediated expression of DAX-1 decreased both HNF4alpha- and forskolin-mediated gluconeogenic gene expressions. Colforsin 70-79 nuclear receptor subfamily 0, group B, member 1 Mus musculus 34-39 19661060-6 2009 The adenylate cyclase activator forskolin also enhanced activation of TRPV4, and the enhancement was antagonized by the selective cyclic AMP-dependent protein kinase (PKA) inhibitor H89 or by mutation of serine residue Ser(824). Colforsin 32-41 transient receptor potential cation channel subfamily V member 4 Homo sapiens 70-75 19755121-0 2009 Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). Colforsin 35-44 regulator of calcineurin 1 Homo sapiens 80-85 19755121-0 2009 Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). Colforsin 35-44 regulator of calcineurin 1 Homo sapiens 87-92 19755121-0 2009 Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). Colforsin 35-44 regulator of calcineurin 1 Homo sapiens 96-103 19755121-2 2009 In this report, we find that activation of adenylate cyclase by forskolin increases the expression of RCAN1 through the increase of the protein"s half-life. Colforsin 64-73 regulator of calcineurin 1 Homo sapiens 102-107 19755121-3 2009 The ability of forskolin to increase the accumulation of RCAN1 protein is significantly inhibited with protein kinase A inhibitors such as KT5720 and H-89. Colforsin 15-24 regulator of calcineurin 1 Homo sapiens 57-62 19755121-4 2009 Furthermore, forskolin targets the central and C-terminal region of RCAN1 and enhances the inhibitory effect of RCAN1 on the calcineurin-mediated activation of NFAT. Colforsin 13-22 regulator of calcineurin 1 Homo sapiens 68-73 19755121-4 2009 Furthermore, forskolin targets the central and C-terminal region of RCAN1 and enhances the inhibitory effect of RCAN1 on the calcineurin-mediated activation of NFAT. Colforsin 13-22 regulator of calcineurin 1 Homo sapiens 112-117 19935854-0 2009 Forskolin attenuates the action of insulin on the Akt-mTOR pathway in human skeletal muscle. Colforsin 0-9 insulin Homo sapiens 35-42 19935854-0 2009 Forskolin attenuates the action of insulin on the Akt-mTOR pathway in human skeletal muscle. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 50-53 19935854-0 2009 Forskolin attenuates the action of insulin on the Akt-mTOR pathway in human skeletal muscle. Colforsin 0-9 mechanistic target of rapamycin kinase Homo sapiens 54-58 19935854-2 2009 The purpose of this investigation was to determine if FSK administration affects various elements of the protein kinase B (Akt)-mammalian target of rapamycin (mTOR) pathway in human skeletal muscle. Colforsin 54-57 AKT serine/threonine kinase 1 Homo sapiens 123-126 19935854-2 2009 The purpose of this investigation was to determine if FSK administration affects various elements of the protein kinase B (Akt)-mammalian target of rapamycin (mTOR) pathway in human skeletal muscle. Colforsin 54-57 mechanistic target of rapamycin kinase Homo sapiens 128-157 19935854-2 2009 The purpose of this investigation was to determine if FSK administration affects various elements of the protein kinase B (Akt)-mammalian target of rapamycin (mTOR) pathway in human skeletal muscle. Colforsin 54-57 mechanistic target of rapamycin kinase Homo sapiens 159-163 19935854-7 2009 Akt phosphorylation was significantly greater in the INS-treated samples compared with the basal and FSK conditions (p = 0.007). Colforsin 101-104 AKT serine/threonine kinase 1 Homo sapiens 0-3 19935854-8 2009 Furthermore, the ratio of phosphorylated Akt to total Akt (P/T) was higher in the INS samples compared with the basal and FSK samples (p = 0.001). Colforsin 122-125 AKT serine/threonine kinase 1 Homo sapiens 41-44 19935854-9 2009 There were no differences in mTOR phosphorylation among the 4 groups; however, total mTOR was significantly greater in the FSK+INS group (p = 0.006). Colforsin 123-126 mechanistic target of rapamycin kinase Homo sapiens 85-89 19496170-7 2009 Importantly, PACAP/VIP as well as forskolin markedly suppressed the induction of alkaline phosphatase mRNA upon differentiation and the pretreatment with 2",5"-dideoxyadenosine, a cAMP inhibitor, restored its inhibitory effect of PACAP. Colforsin 34-43 adenylate cyclase activating polypeptide 1 Mus musculus 230-235 19488761-7 2009 Forskolin-stimulated Cl(-) secretion was mediated by CFTR. Colforsin 0-9 CF transmembrane conductance regulator Sus scrofa 53-57 19686449-8 2009 In concert with these results obtained in vivo, DEX suppressed the forskolin-induced increase in FosB gene promoter activity in a homologous hypothalamic cell line. Colforsin 67-76 FosB proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 97-101 19593209-5 2009 RESULTS: In vitro, R-568 dose-dependently blunted renin release, but also reduced the increase in renin due to forskolin (P < 0.01). Colforsin 111-120 renin Rattus norvegicus 98-103 19620256-3 2009 In a previous report, we showed that treatment of rat midbrain slice explant cultures or mouse MN9D cells with cAMP analog or forskolin leads to induction of TH protein without concomitant induction of TH mRNA. Colforsin 126-135 tyrosine hydroxylase Mus musculus 158-160 19620256-3 2009 In a previous report, we showed that treatment of rat midbrain slice explant cultures or mouse MN9D cells with cAMP analog or forskolin leads to induction of TH protein without concomitant induction of TH mRNA. Colforsin 126-135 tyrosine hydroxylase Mus musculus 202-204 18272254-5 2009 The prevention of the effect of Abeta was shown to occur via the cAMP/PKA signaling pathway as the adenylate cyclase-stimulating agent forskolin prevented the Abeta inhibition of LTP, an action prevented by the PKA inhibitor, Rp-8-Br-cAMPs. Colforsin 135-144 amyloid beta precursor protein Homo sapiens 32-37 18272254-5 2009 The prevention of the effect of Abeta was shown to occur via the cAMP/PKA signaling pathway as the adenylate cyclase-stimulating agent forskolin prevented the Abeta inhibition of LTP, an action prevented by the PKA inhibitor, Rp-8-Br-cAMPs. Colforsin 135-144 amyloid beta precursor protein Homo sapiens 159-164 19789809-6 2009 When forskolin/rolipram or 8CPT-2"O-Me-cAMP, both of which inhibit further reaction of phosphorylated RhoA, were added, no formation of stress fibers or mislocalization of VE-cadherin was observed, thus preventing an increase in endothelial permeability. Colforsin 5-14 ras homolog family member A Homo sapiens 102-106 19602521-8 2009 When tested on cultured ovarian fragments, both goldfish pituitary extract and forskolin significantly stimulated inha expression. Colforsin 79-88 inhibin subunit alpha Danio rerio 114-118 19631660-5 2009 Conversely, the cAMP agonist forskolin prevented glucose-mediated expression of the L-PK gene by decreasing the acetylation of histones H3 and H4 on the promoter, decreasing the methylation of H3-K4 on the coding region, and increasing the methylation of H3-K9 on the coding region. Colforsin 29-38 pyruvate kinase L/R Rattus norvegicus 84-88 19738044-7 2009 PRKAR1A silencing stimulates PKA activity and increases transcriptional activity of a PKA reporter construct and expression of the endogenous PKA target, NR4A2, under basal conditions or after forskolin stimulation. Colforsin 193-202 protein kinase cAMP-dependent type I regulatory subunit alpha Homo sapiens 0-7 19738044-7 2009 PRKAR1A silencing stimulates PKA activity and increases transcriptional activity of a PKA reporter construct and expression of the endogenous PKA target, NR4A2, under basal conditions or after forskolin stimulation. Colforsin 193-202 nuclear receptor subfamily 4 group A member 2 Homo sapiens 154-159 19738044-9 2009 SMAD3 expression was also inhibited by adrenocorticorticotropic hormone in the mouse adrenal gland and by forskolin in H295R cells. Colforsin 106-115 SMAD family member 3 Mus musculus 0-5 19592485-8 2009 We also found constitutive exocytic insertion of NKCC2 in TALs over time, which was increased by 3-fold in the presence of forskolin/IBMX. Colforsin 123-132 solute carrier family 12 member 1 Homo sapiens 49-54 19592485-8 2009 We also found constitutive exocytic insertion of NKCC2 in TALs over time, which was increased by 3-fold in the presence of forskolin/IBMX. Colforsin 123-132 RNA, U4atac small nuclear Homo sapiens 58-62 19695247-4 2009 In forskolin-stimulated conditions, TNFalpha and Db-cAMP pre-treatment decreased stimulated TG-hydrolase activity and impaired PLIN phosphorylation. Colforsin 3-12 tumor necrosis factor Homo sapiens 36-44 19695247-4 2009 In forskolin-stimulated conditions, TNFalpha and Db-cAMP pre-treatment decreased stimulated TG-hydrolase activity and impaired PLIN phosphorylation. Colforsin 3-12 perilipin 1 Homo sapiens 127-131 19535511-3 2009 Forskolin and 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) markedly stimulated duodenal mucosal HCO(3)(-) secretion and short-circuit current (I(sc)) in CFTR wild-type mice, which was significantly inhibited by CFTR(inh)-172, a highly potent and specific CFTR inhibitor. Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 164-168 19151320-7 2009 Activation of protein kinase A (PKA) by forskolin or iloprost resulted in a significant inhibition of SM-alpha-actin expression induced by TGF-beta, and this was associated with inhibition of both SRF expression and activity, but not of Smad-mediated gene transcription. Colforsin 40-49 survival of motor neuron 1, telomeric Homo sapiens 102-110 19535511-6 2009 Forskolin and 8-Br-cGMP induced CFTR phosphorylation and shifted CFTR proteins to the plasma membrane of duodenal epithelial cells, which were inhibited by wortmannin and LY294002. Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 32-36 19535511-6 2009 Forskolin and 8-Br-cGMP induced CFTR phosphorylation and shifted CFTR proteins to the plasma membrane of duodenal epithelial cells, which were inhibited by wortmannin and LY294002. Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 65-69 19535511-7 2009 Forskolin and 8-Br-cGMP not only increased the activity of PI3K but also induced the phosphorylation of Akt, a signaling molecule downstream of PI3K, which were again inhibited by wortmannin and LY294002. Colforsin 0-9 thymoma viral proto-oncogene 1 Mus musculus 104-107 19151320-7 2009 Activation of protein kinase A (PKA) by forskolin or iloprost resulted in a significant inhibition of SM-alpha-actin expression induced by TGF-beta, and this was associated with inhibition of both SRF expression and activity, but not of Smad-mediated gene transcription. Colforsin 40-49 transforming growth factor beta 1 Homo sapiens 139-147 19151320-7 2009 Activation of protein kinase A (PKA) by forskolin or iloprost resulted in a significant inhibition of SM-alpha-actin expression induced by TGF-beta, and this was associated with inhibition of both SRF expression and activity, but not of Smad-mediated gene transcription. Colforsin 40-49 serum response factor Homo sapiens 197-200 19535511-3 2009 Forskolin and 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) markedly stimulated duodenal mucosal HCO(3)(-) secretion and short-circuit current (I(sc)) in CFTR wild-type mice, which was significantly inhibited by CFTR(inh)-172, a highly potent and specific CFTR inhibitor. Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 222-226 19535511-3 2009 Forskolin and 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) markedly stimulated duodenal mucosal HCO(3)(-) secretion and short-circuit current (I(sc)) in CFTR wild-type mice, which was significantly inhibited by CFTR(inh)-172, a highly potent and specific CFTR inhibitor. Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 222-226 19426801-4 2009 wt-hSSTR4 exogenously expressed in HEK-293 cells exhibits constitutive dimerization, inhibits forskolin-stimulated cAMP, and displays agonist dependent changes in pERK1/2 and pERK5 expressions. Colforsin 94-103 somatostatin receptor 4 Homo sapiens 3-9 19719783-7 2009 In contrast, both treatments induced an increase in beta(3)-adrenoceptor expression and beta(3)-adrenoceptor-inhibited forskolin response through PKC, extracellular-signal-regulated kinases 1 and 2 (ERK1/2) and p38MAPK phosphorylation, although no beta(3)-adrenoceptor response was observed in untreated cells. Colforsin 119-128 adrenoceptor beta 3 Rattus norvegicus 88-108 19719783-7 2009 In contrast, both treatments induced an increase in beta(3)-adrenoceptor expression and beta(3)-adrenoceptor-inhibited forskolin response through PKC, extracellular-signal-regulated kinases 1 and 2 (ERK1/2) and p38MAPK phosphorylation, although no beta(3)-adrenoceptor response was observed in untreated cells. Colforsin 119-128 mitogen activated protein kinase 3 Rattus norvegicus 151-197 19719783-7 2009 In contrast, both treatments induced an increase in beta(3)-adrenoceptor expression and beta(3)-adrenoceptor-inhibited forskolin response through PKC, extracellular-signal-regulated kinases 1 and 2 (ERK1/2) and p38MAPK phosphorylation, although no beta(3)-adrenoceptor response was observed in untreated cells. Colforsin 119-128 mitogen activated protein kinase 3 Rattus norvegicus 199-205 19719783-7 2009 In contrast, both treatments induced an increase in beta(3)-adrenoceptor expression and beta(3)-adrenoceptor-inhibited forskolin response through PKC, extracellular-signal-regulated kinases 1 and 2 (ERK1/2) and p38MAPK phosphorylation, although no beta(3)-adrenoceptor response was observed in untreated cells. Colforsin 119-128 adrenoceptor beta 3 Rattus norvegicus 88-108 19439725-4 2009 To elucidate the mechanism of cAMP action, we cloned the rabbit OXTR gene and isolated a 200-base pair (bp) forskolin-responsive region about 4.7 kilobase upstream from the transcriptional start site using transient transfection assays. Colforsin 108-117 oxytocin receptor Oryctolagus cuniculus 64-68 19345211-6 2009 Y-27632 (a Rho kinase inhibitor) and forskolin (known to inhibit activation of RhoA through direct elevation of cAMP) opposed the nocodazole-induced MLC phosphorylation, decrease in TER, and dispersion of ZO-1. Colforsin 37-46 ras homolog family member A Bos taurus 79-83 19540251-5 2009 Bath application of forskolin, an adenylate cyclase activator, caused a rapid and complete inhibition of Slack currents however, the inactive homolog of forskolin, 1,9-dideoxyforskolin caused a similar effect. Colforsin 20-29 potassium sodium-activated channel subfamily T member 1 Homo sapiens 105-110 19472214-5 2009 These effects were reversed by addition of forskolin/rolipram (F/R) to increase intracellular cAMP but not by the cAMP analogue 8-pCPT-2"-O-Methyl-cAMP (O-Me-cAMP) which primarily stimulates protein kinase A (PKA)-independent signaling via Epac/Rap 1. Colforsin 43-52 cathelicidin antimicrobial peptide Homo sapiens 94-98 19472214-5 2009 These effects were reversed by addition of forskolin/rolipram (F/R) to increase intracellular cAMP but not by the cAMP analogue 8-pCPT-2"-O-Methyl-cAMP (O-Me-cAMP) which primarily stimulates protein kinase A (PKA)-independent signaling via Epac/Rap 1. Colforsin 43-52 Rap guanine nucleotide exchange factor 3 Homo sapiens 240-244 19472214-5 2009 These effects were reversed by addition of forskolin/rolipram (F/R) to increase intracellular cAMP but not by the cAMP analogue 8-pCPT-2"-O-Methyl-cAMP (O-Me-cAMP) which primarily stimulates protein kinase A (PKA)-independent signaling via Epac/Rap 1. Colforsin 43-52 RAP1A, member of RAS oncogene family Homo sapiens 245-250 19406844-3 2009 The cAMP agonist forskolin blocked the glucose-mediated induction of the L-PK gene in a PKA-dependent manner and blocked the recruitment of ChREBP, HNF4alpha, and CBP to the L-PK promoter, while simultaneously recruiting CBP to the cAMP-inducible gene, nuclear receptor subfamily 4, group A, member 2 (NR4A2). Colforsin 17-26 pyruvate kinase L/R Rattus norvegicus 73-77 19406844-3 2009 The cAMP agonist forskolin blocked the glucose-mediated induction of the L-PK gene in a PKA-dependent manner and blocked the recruitment of ChREBP, HNF4alpha, and CBP to the L-PK promoter, while simultaneously recruiting CBP to the cAMP-inducible gene, nuclear receptor subfamily 4, group A, member 2 (NR4A2). Colforsin 17-26 MLX interacting protein-like Rattus norvegicus 140-146 19406844-3 2009 The cAMP agonist forskolin blocked the glucose-mediated induction of the L-PK gene in a PKA-dependent manner and blocked the recruitment of ChREBP, HNF4alpha, and CBP to the L-PK promoter, while simultaneously recruiting CBP to the cAMP-inducible gene, nuclear receptor subfamily 4, group A, member 2 (NR4A2). Colforsin 17-26 hepatocyte nuclear factor 4, alpha Rattus norvegicus 148-157 19406844-3 2009 The cAMP agonist forskolin blocked the glucose-mediated induction of the L-PK gene in a PKA-dependent manner and blocked the recruitment of ChREBP, HNF4alpha, and CBP to the L-PK promoter, while simultaneously recruiting CBP to the cAMP-inducible gene, nuclear receptor subfamily 4, group A, member 2 (NR4A2). Colforsin 17-26 CREB binding protein Rattus norvegicus 163-166 19406844-3 2009 The cAMP agonist forskolin blocked the glucose-mediated induction of the L-PK gene in a PKA-dependent manner and blocked the recruitment of ChREBP, HNF4alpha, and CBP to the L-PK promoter, while simultaneously recruiting CBP to the cAMP-inducible gene, nuclear receptor subfamily 4, group A, member 2 (NR4A2). Colforsin 17-26 pyruvate kinase L/R Rattus norvegicus 174-178 19406844-3 2009 The cAMP agonist forskolin blocked the glucose-mediated induction of the L-PK gene in a PKA-dependent manner and blocked the recruitment of ChREBP, HNF4alpha, and CBP to the L-PK promoter, while simultaneously recruiting CBP to the cAMP-inducible gene, nuclear receptor subfamily 4, group A, member 2 (NR4A2). Colforsin 17-26 CREB binding protein Rattus norvegicus 221-224 19406844-3 2009 The cAMP agonist forskolin blocked the glucose-mediated induction of the L-PK gene in a PKA-dependent manner and blocked the recruitment of ChREBP, HNF4alpha, and CBP to the L-PK promoter, while simultaneously recruiting CBP to the cAMP-inducible gene, nuclear receptor subfamily 4, group A, member 2 (NR4A2). Colforsin 17-26 nuclear receptor subfamily 4, group A, member 2 Rattus norvegicus 302-307 19661162-6 2009 Similarly, stimulating Epac by adding forskolin and an inhibitor of PKA significantly increased urea permeability. Colforsin 38-47 Rap guanine nucleotide exchange factor 3 Rattus norvegicus 23-27 19661162-8 2009 Furthermore, forskolin-stimulated cAMP significantly increased ERK 1/2 phosphorylation, which was not prevented by inhibiting PKA, indicating that Epac mediated this phosphorylation of ERK 1/2. Colforsin 13-22 mitogen activated protein kinase 3 Rattus norvegicus 63-70 19661162-8 2009 Furthermore, forskolin-stimulated cAMP significantly increased ERK 1/2 phosphorylation, which was not prevented by inhibiting PKA, indicating that Epac mediated this phosphorylation of ERK 1/2. Colforsin 13-22 Rap guanine nucleotide exchange factor 3 Rattus norvegicus 147-151 19661162-8 2009 Furthermore, forskolin-stimulated cAMP significantly increased ERK 1/2 phosphorylation, which was not prevented by inhibiting PKA, indicating that Epac mediated this phosphorylation of ERK 1/2. Colforsin 13-22 mitogen activated protein kinase 3 Rattus norvegicus 185-192 19661162-9 2009 Inhibition of MEK 1/2 phosphorylation decreased the forskolin-stimulated UT-A1 phosphorylation. Colforsin 52-61 mitogen activated protein kinase kinase 1 Rattus norvegicus 14-21 19189219-6 2009 Functionally, treatment of DCs with endomorphin 1 (EM1), a specific agonist of MOR, can inhibit the forskolin-induced formation of cyclic adenosine monophosphate level in activated DCs. Colforsin 100-109 opioid receptor, mu 1 Mus musculus 79-82 19525486-5 2009 Furthermore, forskolin and isoproterenol-stimulated cAMP responses were enhanced in GPR139-expressing cells, suggesting that GPR139 is predominantly coupled to Galpha(s). Colforsin 13-22 G protein-coupled receptor 139 Homo sapiens 84-90 19706546-5 2009 In vitro, the T allele resulted in CRH promoter activity that was higher following both stimulation with forskolin and treatment with dexamethasone. Colforsin 105-114 corticotropin releasing hormone Macaca mulatta 35-38 19622732-2 2009 Here, we report the physiological role of the intracellular CAII isoform involvement in acid-, PGE(2,) and forskolin-induced murine duodenal bicarbonate secretion (DBS) in vivo. Colforsin 107-116 carbonic anhydrase 2 Mus musculus 60-64 19564544-5 2009 The adenylyl cyclase activator forskolin, the cAMP analogue 8-db-cAMP, and the degranulator compound 48/80 increased renin release without affecting prorenin. Colforsin 31-40 renin Homo sapiens 117-122 19564544-6 2009 Angiotensin II blocked the forskolin-induced renin release. Colforsin 27-36 angiotensinogen Homo sapiens 0-14 19564544-6 2009 Angiotensin II blocked the forskolin-induced renin release. Colforsin 27-36 renin Homo sapiens 45-50 19423690-7 2009 PTH (1 to 31) and forskolin, which activate the cAMP pathway, mimicked the stimulation of TRPV5 activity. Colforsin 18-27 cathelicidin antimicrobial peptide Homo sapiens 48-52 19423690-7 2009 PTH (1 to 31) and forskolin, which activate the cAMP pathway, mimicked the stimulation of TRPV5 activity. Colforsin 18-27 transient receptor potential cation channel subfamily V member 5 Homo sapiens 90-95 19423690-9 2009 Cell surface biotinylation studies demonstrated that forskolin did not affect TRPV5 expression on the cell surface, suggesting that it alters the single-channel activity of a fixed number of TRPV5 channels. Colforsin 53-62 transient receptor potential cation channel subfamily V member 5 Homo sapiens 191-196 19389836-7 2009 Furthermore, inhibition of the cAMP-dependent kinase, protein kinase A (PKA) completely abolished the E2-stimulated GCH1 promoter activity, whereas the stimulation of cAMP levels with forskolin increased GCH1 promoter activity, indicating the key role of cAMP in regulating GCH1 promoter activity. Colforsin 184-193 GTP cyclohydrolase 1 Homo sapiens 204-208 19389836-7 2009 Furthermore, inhibition of the cAMP-dependent kinase, protein kinase A (PKA) completely abolished the E2-stimulated GCH1 promoter activity, whereas the stimulation of cAMP levels with forskolin increased GCH1 promoter activity, indicating the key role of cAMP in regulating GCH1 promoter activity. Colforsin 184-193 GTP cyclohydrolase 1 Homo sapiens 204-208 19525486-5 2009 Furthermore, forskolin and isoproterenol-stimulated cAMP responses were enhanced in GPR139-expressing cells, suggesting that GPR139 is predominantly coupled to Galpha(s). Colforsin 13-22 G protein-coupled receptor 139 Homo sapiens 125-131 19525486-5 2009 Furthermore, forskolin and isoproterenol-stimulated cAMP responses were enhanced in GPR139-expressing cells, suggesting that GPR139 is predominantly coupled to Galpha(s). Colforsin 13-22 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 160-166 19522735-6 2009 Furthermore, activation of D(3) receptors significantly inhibits forskolin-induced cAMP accumulation and leads to transient increases in phosphorylation of cyclin-dependent kinase 5 (Cdk5), dopamine and cAMP-regulated phosphoprotein of M(r) 32 000 and Akt. Colforsin 65-74 AKT serine/threonine kinase 1 Rattus norvegicus 252-255 19491250-7 2009 Microvillar secretory membranes were intact, but basal acid secretion was absent and forskolin-stimulated acid output reduced by approximately 90% in KCNQ1(-/-) gastric mucosa. Colforsin 85-94 potassium voltage-gated channel, subfamily Q, member 1 Mus musculus 150-155 19191026-5 2009 Highly selective muscarinic toxins MT1 and MT2-affinity order M(1) > or = M(4) >> others-and MT3-highly selective M(4) antagonist-did not show significant effects on basal or forskolin-stimulated cyclic AMP production but, like scopolamine, counteracted oxotremorine inhibition. Colforsin 184-193 metallothionein 2A Rattus norvegicus 43-46 19504398-10 2009 In contrast, preincubation with forskolin and rolipram (F/R) to increase cAMP and cytotoxic necrotizing factor 1 to activate Rac 1 and Rho A abolished TNF-alpha-induced barrier breakdown in vivo and in vitro. Colforsin 32-41 Rac family small GTPase 1 Homo sapiens 125-130 19504398-10 2009 In contrast, preincubation with forskolin and rolipram (F/R) to increase cAMP and cytotoxic necrotizing factor 1 to activate Rac 1 and Rho A abolished TNF-alpha-induced barrier breakdown in vivo and in vitro. Colforsin 32-41 ras homolog family member A Homo sapiens 135-140 19504398-10 2009 In contrast, preincubation with forskolin and rolipram (F/R) to increase cAMP and cytotoxic necrotizing factor 1 to activate Rac 1 and Rho A abolished TNF-alpha-induced barrier breakdown in vivo and in vitro. Colforsin 32-41 tumor necrosis factor Homo sapiens 151-160 19491401-2 2009 We have previously reported that C/EBPbeta specifically binds to the CRE on the proximal Pgc-1alpha promoter and increases forskolin-sensitive Pgc-1alpha and Ucp1 expression in white 3T3-L1 preadipocytes. Colforsin 123-132 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 33-42 19652884-0 2009 Effects of the cAMP-elevating agents cilostamide, cilostazol and forskolin on the phosphorylation of Akt and GSK-3beta in platelets. Colforsin 65-74 AKT serine/threonine kinase 1 Rattus norvegicus 101-104 19652884-0 2009 Effects of the cAMP-elevating agents cilostamide, cilostazol and forskolin on the phosphorylation of Akt and GSK-3beta in platelets. Colforsin 65-74 glycogen synthase kinase 3 beta Rattus norvegicus 109-118 19652884-5 2009 The phosphodiesterase-3 (PDE3) inhibitors cilostamide and cilostazol, and the adenylate cyclase activator forskolin, inhibited collagen-induced Akt phosphorylation at Ser473. Colforsin 106-115 AKT serine/threonine kinase 1 Rattus norvegicus 144-147 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 interleukin 6 Homo sapiens 81-84 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 retinoic acid receptor alpha Homo sapiens 93-96 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 mono-ADP ribosylhydrolase 1 Homo sapiens 109-114 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 interleukin 6 Homo sapiens 245-248 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 interferon gamma Homo sapiens 250-258 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 tumor necrosis factor Homo sapiens 263-271 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 mono-ADP ribosylhydrolase 1 Homo sapiens 347-352 19491401-2 2009 We have previously reported that C/EBPbeta specifically binds to the CRE on the proximal Pgc-1alpha promoter and increases forskolin-sensitive Pgc-1alpha and Ucp1 expression in white 3T3-L1 preadipocytes. Colforsin 123-132 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 143-153 19491401-2 2009 We have previously reported that C/EBPbeta specifically binds to the CRE on the proximal Pgc-1alpha promoter and increases forskolin-sensitive Pgc-1alpha and Ucp1 expression in white 3T3-L1 preadipocytes. Colforsin 123-132 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 158-162 19491401-6 2009 In HIB-1B, brown preadipocytes, forskolin increased expression of Pgc-1alpha, Ucp1, and C/ebpbeta early in differentiation and inhibited Chop10 expression. Colforsin 32-41 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 66-76 19491401-6 2009 In HIB-1B, brown preadipocytes, forskolin increased expression of Pgc-1alpha, Ucp1, and C/ebpbeta early in differentiation and inhibited Chop10 expression. Colforsin 32-41 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 78-82 19491401-6 2009 In HIB-1B, brown preadipocytes, forskolin increased expression of Pgc-1alpha, Ucp1, and C/ebpbeta early in differentiation and inhibited Chop10 expression. Colforsin 32-41 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 88-97 19491401-6 2009 In HIB-1B, brown preadipocytes, forskolin increased expression of Pgc-1alpha, Ucp1, and C/ebpbeta early in differentiation and inhibited Chop10 expression. Colforsin 32-41 DNA-damage inducible transcript 3 Mus musculus 137-143 19491401-8 2009 Forskolin stimulation and C/EBPbeta overexpression in 3T3-L1 cells increased C/EBPbeta and CREB but displaced ATF-2 and CHOP10 binding to the Pgc-1alpha proximal CRE. Colforsin 0-9 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 77-86 19491401-8 2009 Forskolin stimulation and C/EBPbeta overexpression in 3T3-L1 cells increased C/EBPbeta and CREB but displaced ATF-2 and CHOP10 binding to the Pgc-1alpha proximal CRE. Colforsin 0-9 cAMP responsive element binding protein 1 Mus musculus 91-95 19491401-8 2009 Forskolin stimulation and C/EBPbeta overexpression in 3T3-L1 cells increased C/EBPbeta and CREB but displaced ATF-2 and CHOP10 binding to the Pgc-1alpha proximal CRE. Colforsin 0-9 activating transcription factor 2 Mus musculus 110-115 19491401-8 2009 Forskolin stimulation and C/EBPbeta overexpression in 3T3-L1 cells increased C/EBPbeta and CREB but displaced ATF-2 and CHOP10 binding to the Pgc-1alpha proximal CRE. Colforsin 0-9 DNA-damage inducible transcript 3 Mus musculus 120-126 19491401-8 2009 Forskolin stimulation and C/EBPbeta overexpression in 3T3-L1 cells increased C/EBPbeta and CREB but displaced ATF-2 and CHOP10 binding to the Pgc-1alpha proximal CRE. Colforsin 0-9 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 142-152 19619286-4 2009 RESULTS: The translocation of nNOS was induced by ATP in the presence of NMDA and forskolin, an adenylate cyclase activator. Colforsin 82-91 nitric oxide synthase 1 Rattus norvegicus 30-34 19429676-4 2009 However, ACSL1 kd adipocytes displayed a 7-fold increase in basal and a approximately 15% increase in forskolin-stimulated fatty acid efflux without any change in glycerol release, indicating a role for the protein in fatty acid reesterification following lipolysis. Colforsin 102-111 acyl-CoA synthetase long-chain family member 1 Mus musculus 9-14 19416972-2 2009 In this study we showed that HAS2 is a primary target of the cAMP activator forskolin and the nuclear hormone all-trans-retinoic acid (RA). Colforsin 76-85 hyaluronan synthase 2 Homo sapiens 29-33 19416972-4 2009 Chromatin immunoprecipitation and re-chromatin immunoprecipitation assays using selected fragments of the promoter containing the putative REs showed that forskolin and all-trans-RA modulate the formation of complexes between CREB1 and RAR with various co-regulators at the predicted sites. Colforsin 155-164 cAMP responsive element binding protein 1 Homo sapiens 226-231 19433586-6 2009 Immunocytochemistry experiments revealed that acute forskolin treatment promotes HSL translocation from the cytosol to small lipid droplets and redistribution of ATGL from the cytosol and large lipid droplets to small lipid droplets, resulting in enriched colocalization of the two lipases. Colforsin 52-61 lipase E, hormone sensitive type Homo sapiens 81-84 19416972-4 2009 Chromatin immunoprecipitation and re-chromatin immunoprecipitation assays using selected fragments of the promoter containing the putative REs showed that forskolin and all-trans-RA modulate the formation of complexes between CREB1 and RAR with various co-regulators at the predicted sites. Colforsin 155-164 retinoic acid receptor alpha Homo sapiens 236-239 19416972-5 2009 Interestingly, CREB1 complexes are regulated by all-trans-RA as are RAR complexes by forskolin. Colforsin 85-94 cAMP responsive element binding protein 1 Homo sapiens 15-20 19416972-5 2009 Interestingly, CREB1 complexes are regulated by all-trans-RA as are RAR complexes by forskolin. Colforsin 85-94 retinoic acid receptor alpha Homo sapiens 68-71 19416972-7 2009 Forskolin and all-trans-RA co-stimulation reduced the binding of CREB1, RAR, and the co-repressor nuclear receptor co-repressor 1 (NCoR1), but enhanced the association of co-activators MED1 and CREB-binding protein (CBP). Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 65-70 19416972-7 2009 Forskolin and all-trans-RA co-stimulation reduced the binding of CREB1, RAR, and the co-repressor nuclear receptor co-repressor 1 (NCoR1), but enhanced the association of co-activators MED1 and CREB-binding protein (CBP). Colforsin 0-9 retinoic acid receptor alpha Homo sapiens 72-75 19416972-7 2009 Forskolin and all-trans-RA co-stimulation reduced the binding of CREB1, RAR, and the co-repressor nuclear receptor co-repressor 1 (NCoR1), but enhanced the association of co-activators MED1 and CREB-binding protein (CBP). Colforsin 0-9 nuclear receptor corepressor 1 Homo sapiens 131-136 19433586-6 2009 Immunocytochemistry experiments revealed that acute forskolin treatment promotes HSL translocation from the cytosol to small lipid droplets and redistribution of ATGL from the cytosol and large lipid droplets to small lipid droplets, resulting in enriched colocalization of the two lipases. Colforsin 52-61 patatin like phospholipase domain containing 2 Homo sapiens 162-166 19416972-7 2009 Forskolin and all-trans-RA co-stimulation reduced the binding of CREB1, RAR, and the co-repressor nuclear receptor co-repressor 1 (NCoR1), but enhanced the association of co-activators MED1 and CREB-binding protein (CBP). Colforsin 0-9 mediator complex subunit 1 Homo sapiens 185-189 19416972-7 2009 Forskolin and all-trans-RA co-stimulation reduced the binding of CREB1, RAR, and the co-repressor nuclear receptor co-repressor 1 (NCoR1), but enhanced the association of co-activators MED1 and CREB-binding protein (CBP). Colforsin 0-9 CREB binding protein Homo sapiens 194-214 19416972-7 2009 Forskolin and all-trans-RA co-stimulation reduced the binding of CREB1, RAR, and the co-repressor nuclear receptor co-repressor 1 (NCoR1), but enhanced the association of co-activators MED1 and CREB-binding protein (CBP). Colforsin 0-9 CREB binding protein Homo sapiens 216-219 19416972-8 2009 RNA interference experiments suggested that MED1 and NCoR1 are central for the all-trans-RA induction of the HAS2 gene and CBP dominates its forskolin response. Colforsin 141-150 CREB binding protein Homo sapiens 123-126 19433586-8 2009 HSL silencing had no effect on basal lipolysis and only partially reduced forskolin-stimulated lipolysis. Colforsin 74-83 lipase E, hormone sensitive type Homo sapiens 0-3 19433586-9 2009 Conversely, silencing of ATGL or CGI-58 significantly reduced basal lipolysis and essentially abolished forskolin-stimulated lipolysis. Colforsin 104-113 patatin like phospholipase domain containing 2 Homo sapiens 25-29 19433586-9 2009 Conversely, silencing of ATGL or CGI-58 significantly reduced basal lipolysis and essentially abolished forskolin-stimulated lipolysis. Colforsin 104-113 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase Homo sapiens 33-39 19509226-5 2009 Treatment of human adipose stromal cells with forskolin and phorbol 12-myristate 13-acetate (PMA), to mimic prostaglandin E(2), resulted in nuclear translocation of CRTC2. Colforsin 46-55 CREB regulated transcription coactivator 2 Homo sapiens 165-170 19447224-1 2009 The diterpene forskolin (FS) binds to, and activates, mammalian membranous adenylyl cyclase (AC) isoforms I-VIII. Colforsin 14-23 cytochrome c oxidase subunit 8A Homo sapiens 108-112 19447224-1 2009 The diterpene forskolin (FS) binds to, and activates, mammalian membranous adenylyl cyclase (AC) isoforms I-VIII. Colforsin 25-27 cytochrome c oxidase subunit 8A Homo sapiens 108-112 19447224-11 2009 The apparent non-competitive interaction of FS with 1-deoxy-FS analogs is explained by impaired ligand exchange due to strong hydrophobic interactions with C1/C2. Colforsin 44-46 heterogeneous nuclear ribonucleoprotein C Homo sapiens 156-161 19509226-9 2009 Adiponectin treatment significantly decreased forskolin/PMA-stimulated aromatase expression, consistent with the decreased nuclear translocation of CRTC2 and the decreased binding of CRTC2 to PII. Colforsin 46-55 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 19509226-10 2009 The expression and activity of the AMP-activated protein kinase LKB1 was examined and found to be significantly decreased following either forskolin/PMA or leptin treatment. Colforsin 139-148 serine/threonine kinase 11 Homo sapiens 64-68 19407217-4 2009 We found that PKA activation using 50 micromol/l forskolin and 5 mmol/l 3-isobutyl-1-methylxanthine stimulated BK channels in cell-attached patches and the catalytic subunit of PKA (200 U/ml) had a similar effect in excised inside-out patches. Colforsin 49-58 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 14-17 19407217-4 2009 We found that PKA activation using 50 micromol/l forskolin and 5 mmol/l 3-isobutyl-1-methylxanthine stimulated BK channels in cell-attached patches and the catalytic subunit of PKA (200 U/ml) had a similar effect in excised inside-out patches. Colforsin 49-58 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 177-180 19398497-11 2009 Meanwhile, forskolin significantly inhibited IL-1beta-induced iNOS protein, which was reversed by H-89, a protein kinase A (PKA) inhibitor. Colforsin 11-20 interleukin 1 beta Rattus norvegicus 45-53 19384851-7 2009 Stimulation of the cells with forskolin or 8BrcAMP also inhibited pERK1/2 and c-Raf.p338. Colforsin 30-39 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 78-83 19282378-7 2009 This effect of alpha-MSH occurred at physiological doses and was due to transcriptional induction, mimicked by the artificial cAMP inducer forskolin, and blocked by protein kinase A pathway inhibition. Colforsin 139-148 proopiomelanocortin Homo sapiens 15-24 19398497-11 2009 Meanwhile, forskolin significantly inhibited IL-1beta-induced iNOS protein, which was reversed by H-89, a protein kinase A (PKA) inhibitor. Colforsin 11-20 nitric oxide synthase 2 Rattus norvegicus 62-66 19398497-11 2009 Meanwhile, forskolin significantly inhibited IL-1beta-induced iNOS protein, which was reversed by H-89, a protein kinase A (PKA) inhibitor. Colforsin 11-20 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 106-122 19398497-11 2009 Meanwhile, forskolin significantly inhibited IL-1beta-induced iNOS protein, which was reversed by H-89, a protein kinase A (PKA) inhibitor. Colforsin 11-20 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 124-127 19457115-3 2009 In contrast, both rhodopsin mRNA concentration and rhodopsin gene promoter activity required the presence of cAMP-increasing agents [forskolin and 3-isobutyl-1-methylxanthine (IBMX)] to reach significant levels. Colforsin 133-142 rhodopsin Gallus gallus 18-27 19457115-3 2009 In contrast, both rhodopsin mRNA concentration and rhodopsin gene promoter activity required the presence of cAMP-increasing agents [forskolin and 3-isobutyl-1-methylxanthine (IBMX)] to reach significant levels. Colforsin 133-142 rhodopsin Gallus gallus 51-60 19324971-7 2009 Our data indicate that this attenuated response may result from inadequate levels of cAMP, because cAMP levels in cultured ERbeta(-/-) granulosa cells exposed to forskolin were approximately 50% lower than in ERbeta(+/+) granulosa cells. Colforsin 162-171 cathelicidin antimicrobial peptide Mus musculus 99-103 19339661-4 2009 Nucleotide sugar-dependent P2Y(14)-R activation was examined by measuring inhibition of forskolin-stimulated cAMP accumulation. Colforsin 88-97 purinergic receptor P2Y14 Homo sapiens 27-36 19324971-7 2009 Our data indicate that this attenuated response may result from inadequate levels of cAMP, because cAMP levels in cultured ERbeta(-/-) granulosa cells exposed to forskolin were approximately 50% lower than in ERbeta(+/+) granulosa cells. Colforsin 162-171 estrogen receptor 2 (beta) Mus musculus 123-129 19450723-6 2009 However, isoproterenol or forskolin stimulation immediately activated PHLPP2, which resulted in markedly dephosphorylation of Akt at Ser473. Colforsin 26-35 PH domain and leucine rich repeat protein phosphatase 2 Rattus norvegicus 70-76 19497718-4 2009 EP3 receptor agonists and PGF(2alpha) were the only active ligands, able to inhibit forskolin-stimulated adenylyl cyclase activity. Colforsin 84-93 prostaglandin E receptor 3 Rattus norvegicus 0-3 19450723-6 2009 However, isoproterenol or forskolin stimulation immediately activated PHLPP2, which resulted in markedly dephosphorylation of Akt at Ser473. Colforsin 26-35 AKT serine/threonine kinase 1 Rattus norvegicus 126-129 19450723-7 2009 Activation of PHLPP2 by isoproterenol and forskolin was cAMP-independent, but required an intact cytoplasmic domain of AC6. Colforsin 42-51 PH domain and leucine rich repeat protein phosphatase 2 Rattus norvegicus 14-20 19254747-8 2009 Forskolin increased Ucn1 mRNA levels, while it decreased Ucn2 and Ucn3 mRNA levels. Colforsin 0-9 urocortin 2 Homo sapiens 57-61 19376132-2 2009 In this report, we demonstrate in the pancreatic beta-cell line MIN6 (mouse insulinoma cell line 6) and islets of Langerhans that agents which stimulate increases in cAMP, such as glucagon-like peptide-1 and forskolin, lead to the phosphorylation of rpS6 at Ser235/Ser236 independently of the activation of the currently known in vivo rpS6 kinases via a pathway that is sensitive to inhibitors of cAMP-dependent protein kinase [protein kinase A (PKA)]. Colforsin 208-217 ribosomal protein S6 Mus musculus 250-254 19376132-2 2009 In this report, we demonstrate in the pancreatic beta-cell line MIN6 (mouse insulinoma cell line 6) and islets of Langerhans that agents which stimulate increases in cAMP, such as glucagon-like peptide-1 and forskolin, lead to the phosphorylation of rpS6 at Ser235/Ser236 independently of the activation of the currently known in vivo rpS6 kinases via a pathway that is sensitive to inhibitors of cAMP-dependent protein kinase [protein kinase A (PKA)]. Colforsin 208-217 ribosomal protein S6 Mus musculus 335-339 19487420-5 2009 Fluorescence recovery after photobleaching analysis showed that exposure to CT, forskolin, or dibutyryl (db) cAMP blocked LPS and IFN-gamma-induced IRF8 binding to chromatin. Colforsin 80-89 interferon gamma Mus musculus 130-139 19487420-5 2009 Fluorescence recovery after photobleaching analysis showed that exposure to CT, forskolin, or dibutyryl (db) cAMP blocked LPS and IFN-gamma-induced IRF8 binding to chromatin. Colforsin 80-89 interferon regulatory factor 8 Mus musculus 148-152 19379723-5 2009 Forskolin, an activator of adenylyl cyclase, as well as dibutyryl cAMP also showed inhibitory effect on the TNF-alpha production in the cells, suggesting involvement of cAMP in TNF-alpha generation. Colforsin 0-9 tumor necrosis factor Mus musculus 108-117 19379723-5 2009 Forskolin, an activator of adenylyl cyclase, as well as dibutyryl cAMP also showed inhibitory effect on the TNF-alpha production in the cells, suggesting involvement of cAMP in TNF-alpha generation. Colforsin 0-9 tumor necrosis factor Mus musculus 177-186 19254747-8 2009 Forskolin increased Ucn1 mRNA levels, while it decreased Ucn2 and Ucn3 mRNA levels. Colforsin 0-9 urocortin 3 Homo sapiens 66-70 19293294-13 2009 SOCS-3 knockdown increased IL-6- or forskolin-induced CRF gene transcription and mRNA levels. Colforsin 36-45 suppressor of cytokine signaling 3 Homo sapiens 0-6 19385062-9 2009 Small interfering RNA-mediated knockdown of Epac1 suppressed forskolin-induced angiogenesis and phosphorylation of ERK, Akt, and eNOS, but not CREB phosphorylation and VEGF expression. Colforsin 61-70 nitric oxide synthase 3 Homo sapiens 129-133 19385062-10 2009 These results suggest that forskolin stimulates angiogenesis through coordinated cross-talk between two distinct pathways, PKA-dependent VEGF expression and Epac-dependent ERKactivation and PI3K/Akt/eNOS/NO signaling. Colforsin 27-36 vascular endothelial growth factor A Homo sapiens 137-141 19385062-10 2009 These results suggest that forskolin stimulates angiogenesis through coordinated cross-talk between two distinct pathways, PKA-dependent VEGF expression and Epac-dependent ERKactivation and PI3K/Akt/eNOS/NO signaling. Colforsin 27-36 Rap guanine nucleotide exchange factor 3 Homo sapiens 157-161 19385062-10 2009 These results suggest that forskolin stimulates angiogenesis through coordinated cross-talk between two distinct pathways, PKA-dependent VEGF expression and Epac-dependent ERKactivation and PI3K/Akt/eNOS/NO signaling. Colforsin 27-36 AKT serine/threonine kinase 1 Homo sapiens 195-198 19385062-10 2009 These results suggest that forskolin stimulates angiogenesis through coordinated cross-talk between two distinct pathways, PKA-dependent VEGF expression and Epac-dependent ERKactivation and PI3K/Akt/eNOS/NO signaling. Colforsin 27-36 nitric oxide synthase 3 Homo sapiens 199-203 19235835-4 2009 We then compare these effects to the phenotypes produced by exposure to two drugs that also inhibit Shh-s: cyclopamine and forskolin. Colforsin 123-132 sonic hedgehog signaling molecule a Danio rerio 100-103 19235835-8 2009 Despite the differences between cyclopamine and forskolin, we found that shh mRNA injection rescued the short body length, the alteration in somite shape, and the cyclopia produced by ethanol exposure. Colforsin 48-57 sonic hedgehog signaling molecule a Danio rerio 73-76 19385062-0 2009 Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling. Colforsin 0-9 vascular endothelial growth factor A Homo sapiens 86-90 19385062-0 2009 Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling. Colforsin 0-9 Rap guanine nucleotide exchange factor 3 Homo sapiens 106-110 19385062-0 2009 Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 125-128 19385062-0 2009 Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling. Colforsin 0-9 nitric oxide synthase 3 Homo sapiens 129-133 19385062-3 2009 Forskolin stimulated angiogenesis of human endothelial cells and in vivo neovascularization, which was accompanied by phosphorylation of CREB, ERK, Akt, and endothelial nitric oxide synthase (eNOS) as well as NO production and VEGF expression. Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 137-141 19385062-3 2009 Forskolin stimulated angiogenesis of human endothelial cells and in vivo neovascularization, which was accompanied by phosphorylation of CREB, ERK, Akt, and endothelial nitric oxide synthase (eNOS) as well as NO production and VEGF expression. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 143-146 19385062-3 2009 Forskolin stimulated angiogenesis of human endothelial cells and in vivo neovascularization, which was accompanied by phosphorylation of CREB, ERK, Akt, and endothelial nitric oxide synthase (eNOS) as well as NO production and VEGF expression. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 148-151 19385062-3 2009 Forskolin stimulated angiogenesis of human endothelial cells and in vivo neovascularization, which was accompanied by phosphorylation of CREB, ERK, Akt, and endothelial nitric oxide synthase (eNOS) as well as NO production and VEGF expression. Colforsin 0-9 nitric oxide synthase 3 Homo sapiens 157-190 19385062-3 2009 Forskolin stimulated angiogenesis of human endothelial cells and in vivo neovascularization, which was accompanied by phosphorylation of CREB, ERK, Akt, and endothelial nitric oxide synthase (eNOS) as well as NO production and VEGF expression. Colforsin 0-9 nitric oxide synthase 3 Homo sapiens 192-196 19385062-3 2009 Forskolin stimulated angiogenesis of human endothelial cells and in vivo neovascularization, which was accompanied by phosphorylation of CREB, ERK, Akt, and endothelial nitric oxide synthase (eNOS) as well as NO production and VEGF expression. Colforsin 0-9 vascular endothelial growth factor A Homo sapiens 227-231 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 18-22 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 0-9 vascular endothelial growth factor A Homo sapiens 40-44 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 0-9 vascular endothelial growth factor A Homo sapiens 68-72 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 151-154 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 0-9 mitogen-activated protein kinase kinase 7 Homo sapiens 189-192 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 158-167 cAMP responsive element binding protein 1 Homo sapiens 18-22 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 158-167 vascular endothelial growth factor A Homo sapiens 40-44 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 158-167 vascular endothelial growth factor A Homo sapiens 68-72 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 158-167 mitogen-activated protein kinase 1 Homo sapiens 151-154 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 158-167 mitogen-activated protein kinase kinase 7 Homo sapiens 189-192 19385062-5 2009 The forskolin-induced Akt/eNOS/NO pathway was completely inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, but not significantly suppressed by PKI. Colforsin 4-13 AKT serine/threonine kinase 1 Homo sapiens 22-25 19385062-5 2009 The forskolin-induced Akt/eNOS/NO pathway was completely inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, but not significantly suppressed by PKI. Colforsin 4-13 nitric oxide synthase 3 Homo sapiens 26-30 19385062-5 2009 The forskolin-induced Akt/eNOS/NO pathway was completely inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, but not significantly suppressed by PKI. Colforsin 4-13 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 74-103 19385062-9 2009 Small interfering RNA-mediated knockdown of Epac1 suppressed forskolin-induced angiogenesis and phosphorylation of ERK, Akt, and eNOS, but not CREB phosphorylation and VEGF expression. Colforsin 61-70 Rap guanine nucleotide exchange factor 3 Homo sapiens 44-49 19385062-9 2009 Small interfering RNA-mediated knockdown of Epac1 suppressed forskolin-induced angiogenesis and phosphorylation of ERK, Akt, and eNOS, but not CREB phosphorylation and VEGF expression. Colforsin 61-70 mitogen-activated protein kinase 1 Homo sapiens 115-118 19385062-9 2009 Small interfering RNA-mediated knockdown of Epac1 suppressed forskolin-induced angiogenesis and phosphorylation of ERK, Akt, and eNOS, but not CREB phosphorylation and VEGF expression. Colforsin 61-70 AKT serine/threonine kinase 1 Homo sapiens 120-123 19151997-9 2009 Mutation of this residue to alanine resulted in a reduced sensitivity of Kir3.1* currents to H89 and Forskolin, confirming an in vivo role for this novel site of the Kir3.1 channel subunit in its regulation by PKA. Colforsin 101-110 potassium inwardly rectifying channel subfamily J member 3 Homo sapiens 73-79 19403597-8 2009 Applied during tonic force, forskolin caused a rapid decrease in MLCK FRET ratio and force, but no change in Ca(2+), suggesting a cAMP mediated decrease in affinity of MLCK for Ca(2+)/CaM. Colforsin 28-37 myosin light chain kinase 3 Mus musculus 65-69 19403597-8 2009 Applied during tonic force, forskolin caused a rapid decrease in MLCK FRET ratio and force, but no change in Ca(2+), suggesting a cAMP mediated decrease in affinity of MLCK for Ca(2+)/CaM. Colforsin 28-37 myosin light chain kinase 3 Mus musculus 168-172 19403597-13 2009 Forskolin mediated increases in cAMP, but not receptor mediated increases in cAMP cause a rapid decrease in the affinity of MLCK for Ca(2+)/CaM. Colforsin 0-9 myosin light chain kinase 3 Mus musculus 124-128 19371952-4 2009 Both forskolin (a direct activator of adenylyl cyclase) and dibutyryl-cAMP (DBcAMP, a permeable analog of cAMP) suppressed production of TARC and MDC in parallel with the activation of NF-kappaB in IFN-gamma and TNF-alpha-stimulated HaCaT cells. Colforsin 5-14 C-C motif chemokine ligand 17 Homo sapiens 137-141 19371952-4 2009 Both forskolin (a direct activator of adenylyl cyclase) and dibutyryl-cAMP (DBcAMP, a permeable analog of cAMP) suppressed production of TARC and MDC in parallel with the activation of NF-kappaB in IFN-gamma and TNF-alpha-stimulated HaCaT cells. Colforsin 5-14 C-C motif chemokine ligand 22 Homo sapiens 146-149 19371952-4 2009 Both forskolin (a direct activator of adenylyl cyclase) and dibutyryl-cAMP (DBcAMP, a permeable analog of cAMP) suppressed production of TARC and MDC in parallel with the activation of NF-kappaB in IFN-gamma and TNF-alpha-stimulated HaCaT cells. Colforsin 5-14 interferon gamma Homo sapiens 198-207 19371952-4 2009 Both forskolin (a direct activator of adenylyl cyclase) and dibutyryl-cAMP (DBcAMP, a permeable analog of cAMP) suppressed production of TARC and MDC in parallel with the activation of NF-kappaB in IFN-gamma and TNF-alpha-stimulated HaCaT cells. Colforsin 5-14 tumor necrosis factor Homo sapiens 212-221 19371952-8 2009 Of note, the IFN-gamma plus TNF-alpha-stimulated activation of p38 MAPK was suppressed following incubation with forskolin or DBcAMP alone. Colforsin 113-122 interferon gamma Homo sapiens 13-22 19371952-8 2009 Of note, the IFN-gamma plus TNF-alpha-stimulated activation of p38 MAPK was suppressed following incubation with forskolin or DBcAMP alone. Colforsin 113-122 tumor necrosis factor Homo sapiens 28-37 19371952-8 2009 Of note, the IFN-gamma plus TNF-alpha-stimulated activation of p38 MAPK was suppressed following incubation with forskolin or DBcAMP alone. Colforsin 113-122 mitogen-activated protein kinase 14 Homo sapiens 63-66 19151997-9 2009 Mutation of this residue to alanine resulted in a reduced sensitivity of Kir3.1* currents to H89 and Forskolin, confirming an in vivo role for this novel site of the Kir3.1 channel subunit in its regulation by PKA. Colforsin 101-110 potassium inwardly rectifying channel subfamily J member 3 Homo sapiens 166-172 19234087-4 2009 Sustained elevation of cAMP by either chlorophenylthiol (CPT)-cAMP or forskolin increased the HERG channel protein abundance two- to fourfold within 24 h, with measurable difference as early as 4 h. The cAMP-induced augmentation was not due to changes in transcription and was specific for HERG compared with other cardiac K(+) channels (Kv1.4, Kv1.5, Kir2.1, and KvLQT1). Colforsin 70-79 potassium voltage-gated channel subfamily H member 2 Homo sapiens 94-98 19285714-5 2009 The tension induced by ET-1 was dose-dependently reversed by the drugs with the following rank order of efficacy: rolipram, forskolin, tadalafil, sodium nitroprusside, sildenafil, vinpocetine, vardenafil, EHNA. Colforsin 124-133 endothelin 1 Homo sapiens 23-27 19416907-6 2009 The impaired induction of the crh gene by neurogenic signals was corroborated in AtT-20 cells, where siRNA and overexpression experiments showed that SRC-1 is necessary for full induction of a CRH promoter reporter gene by forskolin, suggestive of involvement of transcription factor CREB. Colforsin 223-232 corticotropin releasing hormone Mus musculus 30-33 19416907-6 2009 The impaired induction of the crh gene by neurogenic signals was corroborated in AtT-20 cells, where siRNA and overexpression experiments showed that SRC-1 is necessary for full induction of a CRH promoter reporter gene by forskolin, suggestive of involvement of transcription factor CREB. Colforsin 223-232 nuclear receptor coactivator 1 Mus musculus 150-155 19416907-6 2009 The impaired induction of the crh gene by neurogenic signals was corroborated in AtT-20 cells, where siRNA and overexpression experiments showed that SRC-1 is necessary for full induction of a CRH promoter reporter gene by forskolin, suggestive of involvement of transcription factor CREB. Colforsin 223-232 corticotropin releasing hormone Mus musculus 193-196 19390057-7 2009 In agreement, thrombin elevated cGMP but decreased cAMP levels, whereas db-cAMP or forskolin diminished Rac1 activity and ROS production. Colforsin 83-92 Rac family small GTPase 1 Mus musculus 104-108 19279233-5 2009 Coincubation with agents that elevate cellular cAMP [the ADO agonist, 5"-N-ethylcarboxamidoadensoine (NECA), and forskolin] inhibited the stimulatory effects of ANG II. Colforsin 113-122 angiotensinogen Rattus norvegicus 161-167 19234087-4 2009 Sustained elevation of cAMP by either chlorophenylthiol (CPT)-cAMP or forskolin increased the HERG channel protein abundance two- to fourfold within 24 h, with measurable difference as early as 4 h. The cAMP-induced augmentation was not due to changes in transcription and was specific for HERG compared with other cardiac K(+) channels (Kv1.4, Kv1.5, Kir2.1, and KvLQT1). Colforsin 70-79 potassium voltage-gated channel subfamily H member 2 Homo sapiens 290-294 19234087-4 2009 Sustained elevation of cAMP by either chlorophenylthiol (CPT)-cAMP or forskolin increased the HERG channel protein abundance two- to fourfold within 24 h, with measurable difference as early as 4 h. The cAMP-induced augmentation was not due to changes in transcription and was specific for HERG compared with other cardiac K(+) channels (Kv1.4, Kv1.5, Kir2.1, and KvLQT1). Colforsin 70-79 potassium voltage-gated channel subfamily A member 4 Homo sapiens 338-343 19234087-4 2009 Sustained elevation of cAMP by either chlorophenylthiol (CPT)-cAMP or forskolin increased the HERG channel protein abundance two- to fourfold within 24 h, with measurable difference as early as 4 h. The cAMP-induced augmentation was not due to changes in transcription and was specific for HERG compared with other cardiac K(+) channels (Kv1.4, Kv1.5, Kir2.1, and KvLQT1). Colforsin 70-79 potassium voltage-gated channel subfamily A member 5 Homo sapiens 345-350 19234087-4 2009 Sustained elevation of cAMP by either chlorophenylthiol (CPT)-cAMP or forskolin increased the HERG channel protein abundance two- to fourfold within 24 h, with measurable difference as early as 4 h. The cAMP-induced augmentation was not due to changes in transcription and was specific for HERG compared with other cardiac K(+) channels (Kv1.4, Kv1.5, Kir2.1, and KvLQT1). Colforsin 70-79 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 352-358 19234087-4 2009 Sustained elevation of cAMP by either chlorophenylthiol (CPT)-cAMP or forskolin increased the HERG channel protein abundance two- to fourfold within 24 h, with measurable difference as early as 4 h. The cAMP-induced augmentation was not due to changes in transcription and was specific for HERG compared with other cardiac K(+) channels (Kv1.4, Kv1.5, Kir2.1, and KvLQT1). Colforsin 70-79 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 364-370 19048368-5 2009 Activation of intracellular cyclic adenosine monophosphate or protein kinase C with forskolin and phorbol 12-myristate 13-acetate, respectively, was able to completely abolish the MCP-1-induced migration. Colforsin 84-93 C-C motif chemokine ligand 2 Homo sapiens 180-185 19285039-7 2009 Treatment with forskolin, an agent that mimics axonal signaling, suppressed the expression of IL-6-inducible genes. Colforsin 15-24 interleukin 6 Homo sapiens 94-98 19268649-4 2009 Pretreatment of platelets with cAMP-elevating agent, forskolin, abolished thrombin plus collagen-induced MP formation and PS exposure, and obviously decreased calcium ionophore-evoked MP shedding. Colforsin 53-62 coagulation factor II, thrombin Homo sapiens 74-82 19268649-6 2009 PKA inhibitor-induced MP formation was dose-dependently inhibited by calpain inhibitor MDL28170, and forskolin abrogated thrombin plus collagen-induced calpain activation. Colforsin 101-110 coagulation factor II, thrombin Homo sapiens 121-129 19166925-5 2009 siRNA-mediated depletion of Hsp27 protein levels, as well as overexpression of the non-phosphorylatable Hsp27-3A mutant prevented forskolin-induced F-actin reorganization. Colforsin 130-139 heat shock protein family B (small) member 1 Rattus norvegicus 104-109 19219068-6 2009 The GCM1 expression was either inhibited by siRNA and antisense oligonucleotides methods or upregulated by forskolin treatment. Colforsin 107-116 glial cells missing transcription factor 1 Homo sapiens 4-8 19219068-9 2009 By contrast, forskolin-induced expression of GCM1 reduced the rate of proliferation and increased the rate of syncytialization in the floating villous explant model. Colforsin 13-22 glial cells missing transcription factor 1 Homo sapiens 45-49 19190109-11 2009 After type I GnRH-R silencing: 1) the antiproliferative effect of GnRH-II was completely abrogated; and 2) GnRH-II lost its capacity to counteract the forskolin-induced cAMP accumulation. Colforsin 151-160 gonadotropin releasing hormone receptor Homo sapiens 13-19 19223474-5 2009 Importantly, B cells treated with CT, LT, or FSK were able to induce pronounced proliferation of both CD4(+) and CD8(+) allogeneic T cells compared with untreated B cells and B cells treated with CT-B and LTK63. Colforsin 45-48 phosphate cytidylyltransferase 1B, choline Homo sapiens 196-200 19261611-8 2009 In contrast, cAMP-elevating agents such as PGE(1) and forskolin-induced phosphorylation of Ser(312) and increased PDE3A activity, but did not stimulate 14-3-3 binding. Colforsin 54-63 cathelicidin antimicrobial peptide Homo sapiens 13-17 19261611-8 2009 In contrast, cAMP-elevating agents such as PGE(1) and forskolin-induced phosphorylation of Ser(312) and increased PDE3A activity, but did not stimulate 14-3-3 binding. Colforsin 54-63 phosphodiesterase 3A Homo sapiens 114-119 19190109-11 2009 After type I GnRH-R silencing: 1) the antiproliferative effect of GnRH-II was completely abrogated; and 2) GnRH-II lost its capacity to counteract the forskolin-induced cAMP accumulation. Colforsin 151-160 gonadotropin releasing hormone 2 Homo sapiens 66-73 19190109-11 2009 After type I GnRH-R silencing: 1) the antiproliferative effect of GnRH-II was completely abrogated; and 2) GnRH-II lost its capacity to counteract the forskolin-induced cAMP accumulation. Colforsin 151-160 gonadotropin releasing hormone 2 Homo sapiens 107-114 19360304-8 2009 Moreover, the GnRH agonist significantly counteracted the forskolin-induced increase of intracellular cAMP levels in these cells. Colforsin 58-67 gonadotropin releasing hormone 1 Homo sapiens 14-18 19381016-7 2009 Secretion triggered by SubP was synergistic with vasoactive intestinal peptide and/or forskolin but not with carbachol; synergy was absent in CF glands. Colforsin 86-95 tachykinin precursor 1 Homo sapiens 23-27 19181367-7 2009 PKA inhibition mediated GPIbalpha shedding was reversed by PKA activator forskolin and partially inhibited by membrane-permeable calpain inhibitors. Colforsin 73-82 glycoprotein Ib platelet subunit alpha Homo sapiens 24-33 19022884-9 2009 BMP-2 and BMP-4 inhibited FSH- and forskolin (FSK)-induced progesterone and cAMP synthesis regardless of oocyte action. Colforsin 35-44 bone morphogenetic protein 2 Rattus norvegicus 0-5 19167456-10 2009 Inhibition of NF-kappaB by 15d-PGJ(2) was prevented by addition of forskolin, a PKA activator. Colforsin 67-76 nuclear factor kappa B subunit 1 Homo sapiens 14-23 19022892-6 2009 Using reporter gene assays in 4B cells, or quantitative RT-PCR for primary transcript in hypothalamic cell cultures, PRL potentiated forskolin-stimulated CRH transcription through activation of the ERK/MAPK pathway. Colforsin 133-142 prolactin Rattus norvegicus 117-120 19022884-9 2009 BMP-2 and BMP-4 inhibited FSH- and forskolin (FSK)-induced progesterone and cAMP synthesis regardless of oocyte action. Colforsin 35-44 bone morphogenetic protein 4 Rattus norvegicus 10-15 19022892-6 2009 Using reporter gene assays in 4B cells, or quantitative RT-PCR for primary transcript in hypothalamic cell cultures, PRL potentiated forskolin-stimulated CRH transcription through activation of the ERK/MAPK pathway. Colforsin 133-142 corticotropin releasing hormone Rattus norvegicus 154-157 19022884-9 2009 BMP-2 and BMP-4 inhibited FSH- and forskolin (FSK)-induced progesterone and cAMP synthesis regardless of oocyte action. Colforsin 46-49 bone morphogenetic protein 2 Rattus norvegicus 0-5 19022892-6 2009 Using reporter gene assays in 4B cells, or quantitative RT-PCR for primary transcript in hypothalamic cell cultures, PRL potentiated forskolin-stimulated CRH transcription through activation of the ERK/MAPK pathway. Colforsin 133-142 Eph receptor B1 Rattus norvegicus 198-201 19022884-9 2009 BMP-2 and BMP-4 inhibited FSH- and forskolin (FSK)-induced progesterone and cAMP synthesis regardless of oocyte action. Colforsin 46-49 bone morphogenetic protein 4 Rattus norvegicus 10-15 19054056-3 2009 Quantitative analysis of [(14)C]-2-TU incorporation showed a significant increase in pigmented hair follicles upon stimulation with 1 microm forskolin concomitant to an increase in tyrosinase levels. Colforsin 141-150 tyrosinase Homo sapiens 181-191 19289574-8 2009 HEK cells coexpressing SLC26A9 and wtCFTR displayed similar properties, as well as forskolin-stimulated currents that exceeded the sum of those in cells separately expressing SLC26A9 or wtCFTR, and an I-V relation during GlyH-101 inhibition that was moderately IR, indicating that SLC26A9 contributed to the stimulated current. Colforsin 83-92 solute carrier family 26 member 9 Homo sapiens 23-30 19289574-8 2009 HEK cells coexpressing SLC26A9 and wtCFTR displayed similar properties, as well as forskolin-stimulated currents that exceeded the sum of those in cells separately expressing SLC26A9 or wtCFTR, and an I-V relation during GlyH-101 inhibition that was moderately IR, indicating that SLC26A9 contributed to the stimulated current. Colforsin 83-92 solute carrier family 26 member 9 Homo sapiens 175-182 19289574-8 2009 HEK cells coexpressing SLC26A9 and wtCFTR displayed similar properties, as well as forskolin-stimulated currents that exceeded the sum of those in cells separately expressing SLC26A9 or wtCFTR, and an I-V relation during GlyH-101 inhibition that was moderately IR, indicating that SLC26A9 contributed to the stimulated current. Colforsin 83-92 solute carrier family 26 member 9 Homo sapiens 175-182 19088066-5 2009 We then tested correction of F508del-CFTR function by the CI(-)/l(-) exchange method following stimulation with forskolin/IBMX/genistein, using quantitative recordings in multiple individual cells with a high-content (high-throughput) Cellomics KSR imaging system. Colforsin 112-121 CF transmembrane conductance regulator Homo sapiens 37-41 19244346-7 2009 In polarized T84 monolayers, adenoviral expression of Rab11b-S25N resulted in a 70% inhibition of forskolin-stimulated transepithelial anion secretion and a 50% decrease in apical membrane CFTR as assessed by cell surface biotinylation. Colforsin 98-107 RAB11B, member RAS oncogene family Homo sapiens 54-60 19087231-1 2009 We previously reported that topical application of forskolin to the skin of fair-skinned MC1R-defective mice with epidermal melanocytes resulted in accumulation of eumelanin in the epidermis and was highly protective against UV-mediated cutaneous injury. Colforsin 51-60 melanocortin 1 receptor Mus musculus 89-93 18787837-8 2009 Forskolin and insulin both stimulated this current and the response to insulin, but not forskolin, was LY294002-sensitive and associated with the activation of SGK1. Colforsin 0-9 serum/glucocorticoid regulated kinase 1 Homo sapiens 160-164 19171674-6 2009 In addition, 5,6-EET-EA inhibited the forskolin-stimulated accumulation of cAMP in CHO cells stably expressing the CB2 receptor (IC(50) = 9.8 +/- 1.3 nM). Colforsin 38-47 cannabinoid receptor 2 Cricetulus griseus 115-118 19026713-3 2009 The expression of CYP19 transcripts and protein were markedly induced in the H295 adrenocortical carcinoma cell line after treatment with either forskolin or vasoactive intestinal peptide (VIP). Colforsin 145-154 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 18-23 19397442-0 2009 Forskolin decreases phosphorylation of histone H2AX in human cells induced by ionizing radiation. Colforsin 0-9 H2A.X variant histone Homo sapiens 39-51 19397442-3 2009 It is unknown whether forskolin can effect cellular responses to ionizing radiation, such as induction of phosphorylation of histone H2AX (gamma-H2AX) in megabase chromatin domains near DNA double-strand breaks (DSBs). Colforsin 22-31 H2A.X variant histone Homo sapiens 125-137 19397442-3 2009 It is unknown whether forskolin can effect cellular responses to ionizing radiation, such as induction of phosphorylation of histone H2AX (gamma-H2AX) in megabase chromatin domains near DNA double-strand breaks (DSBs). Colforsin 22-31 H2A.X variant histone Homo sapiens 139-149 19397442-4 2009 Here we report that treatment with forskolin decreases H2AX phosphorylation after irradiation detected by immunoblotting or by analysis of the overall gamma-H2AX-associated fluorescence in the nuclei. Colforsin 35-44 H2A.X variant histone Homo sapiens 55-59 19397442-4 2009 Here we report that treatment with forskolin decreases H2AX phosphorylation after irradiation detected by immunoblotting or by analysis of the overall gamma-H2AX-associated fluorescence in the nuclei. Colforsin 35-44 H2A.X variant histone Homo sapiens 151-161 19397442-6 2009 We suggest that the overall decrease of H2AX phosphorylation after treatment with forskolin in irradiated cells reflects a lesser extent of apparent H2AX modification at individual DSBs that may be caused by inhibition of the initial spread of gamma-H2AX and/or by stimulation of elimination of gamma-H2AX from chromatin after DSB rejoining. Colforsin 82-91 H2A.X variant histone Homo sapiens 40-44 19397442-6 2009 We suggest that the overall decrease of H2AX phosphorylation after treatment with forskolin in irradiated cells reflects a lesser extent of apparent H2AX modification at individual DSBs that may be caused by inhibition of the initial spread of gamma-H2AX and/or by stimulation of elimination of gamma-H2AX from chromatin after DSB rejoining. Colforsin 82-91 H2A.X variant histone Homo sapiens 244-254 19397442-6 2009 We suggest that the overall decrease of H2AX phosphorylation after treatment with forskolin in irradiated cells reflects a lesser extent of apparent H2AX modification at individual DSBs that may be caused by inhibition of the initial spread of gamma-H2AX and/or by stimulation of elimination of gamma-H2AX from chromatin after DSB rejoining. Colforsin 82-91 H2A.X variant histone Homo sapiens 295-305 19356686-7 2009 Activation of N-methyl-D-aspartate (NMDA) receptors by intravitreous injection of NMDA or increase of cAMP signaling by administration of forskolin triggered nuclear accumulation of TORC1. Colforsin 138-147 CREB regulated transcription coactivator 1 Rattus norvegicus 182-187 19144650-7 2009 Duox1 but not Duox2 activity is stimulated by forskolin (EC(50) = 0.1 microm) via protein kinase A-mediated Duox1 phosphorylation on serine 955. Colforsin 46-55 dual oxidase 1 Homo sapiens 0-5 19144650-7 2009 Duox1 but not Duox2 activity is stimulated by forskolin (EC(50) = 0.1 microm) via protein kinase A-mediated Duox1 phosphorylation on serine 955. Colforsin 46-55 dual oxidase 1 Homo sapiens 108-113 19026713-4 2009 Western immunoblotting demonstrated a marked induction of the CYP19 protein of characteristic size after only a short (6h) treatment period with VIP or forskolin. Colforsin 152-161 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 62-67 19244110-4 2009 We show through exon microarray, transcript analysis, and functional assays that RGS17 promotes cyclic AMP (cAMP)-responsive element binding protein (CREB)-responsive gene expression, increases cAMP levels, and enhances forskolin-mediated cAMP production. Colforsin 220-229 regulator of G protein signaling 17 Homo sapiens 81-86 19401039-7 2009 Forskolin-stimulated I(SC) was inhibited by the specific cystic fibrosis transmembrane regulator (CFTR) inhibitor INH-172 (5 microM). Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 57-96 19401039-7 2009 Forskolin-stimulated I(SC) was inhibited by the specific cystic fibrosis transmembrane regulator (CFTR) inhibitor INH-172 (5 microM). Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 98-102 19118163-4 2009 Both inhibition of Rac 1 activation by NSC-23766 and inhibition of PKA by PKI completely blunted the efficacy of forskolin/rolipram (F/R)-mediated cAMP increase to stabilize barrier functions as revealed by measurements of transendothelial resistance (TER). Colforsin 113-122 Rac family small GTPase 1 Mus musculus 19-24 19183261-3 2009 Both agonists produced increases in mRNA expression of Shh-regulated gene targets, Gli-1 and Patched in a cyclopamine- and forskolin-sensitive manner. Colforsin 123-132 sonic hedgehog signaling molecule Homo sapiens 55-58 19221439-4 2009 We found that Nherf1 ablation strongly reduced basal as well as forskolin-stimulated (FSK-stimulated) HCO3- secretory rates and blocked beta2-adrenergic receptor (beta2-AR) stimulation. Colforsin 64-73 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 14-20 19022848-6 2009 The activation of the ERK1/2 and Akt pathways as well as the expression of EGFR was stimulated by reagents that elevate intracellular cAMP levels, via cAMP analog 8-bromo-cAMP and AC activator forskolin. Colforsin 193-202 mitogen-activated protein kinase 3 Homo sapiens 22-28 19022848-6 2009 The activation of the ERK1/2 and Akt pathways as well as the expression of EGFR was stimulated by reagents that elevate intracellular cAMP levels, via cAMP analog 8-bromo-cAMP and AC activator forskolin. Colforsin 193-202 AKT serine/threonine kinase 1 Homo sapiens 33-36 19022848-6 2009 The activation of the ERK1/2 and Akt pathways as well as the expression of EGFR was stimulated by reagents that elevate intracellular cAMP levels, via cAMP analog 8-bromo-cAMP and AC activator forskolin. Colforsin 193-202 epidermal growth factor receptor Homo sapiens 75-79 18835829-5 2009 Even though Nur77 expression is induced both at the mRNA and protein levels in response to LH/forskolin/cAMP in Leydig cells, the mechanisms involved remain largely unknown. Colforsin 94-103 nuclear receptor subfamily 4, group A, member 1 Mus musculus 12-17 19183261-3 2009 Both agonists produced increases in mRNA expression of Shh-regulated gene targets, Gli-1 and Patched in a cyclopamine- and forskolin-sensitive manner. Colforsin 123-132 GLI family zinc finger 1 Homo sapiens 83-88 19115253-5 2009 Experiments using an anti-phosphopeptide antibody revealed that forskolin also increased the extent of phosphorylation of SGLT1 in the membrane fraction. Colforsin 64-73 solute carrier family 5 member 1 Homo sapiens 122-127 19182900-5 2009 Only inhibitors of signaling enzymes that prevented ATP release (forskolin, PGE(1), or BIMI-1) prevented or delayed the generation of PAR-1-(1-41) and PAR-4-(1-47) in response to all three agonists. Colforsin 65-74 coagulation factor II thrombin receptor Homo sapiens 134-139 19182900-5 2009 Only inhibitors of signaling enzymes that prevented ATP release (forskolin, PGE(1), or BIMI-1) prevented or delayed the generation of PAR-1-(1-41) and PAR-4-(1-47) in response to all three agonists. Colforsin 65-74 Prader Willi/Angelman region RNA 4 Homo sapiens 151-156 18831067-4 2009 By means of a clone stably transfected with a relaxin 3 promoter-EGFP gene, we observed that dibutyryl cyclic AMP and forskolin increased the relaxin 3 promoter activity. Colforsin 118-127 relaxin 3 Mus musculus 46-55 18831067-4 2009 By means of a clone stably transfected with a relaxin 3 promoter-EGFP gene, we observed that dibutyryl cyclic AMP and forskolin increased the relaxin 3 promoter activity. Colforsin 118-127 relaxin 3 Mus musculus 142-151 19195485-5 2009 Forskolin (an adenylyl cyclase activator) and dibutyryl cAMP also inhibited the IL-12-induced IFN-gamma synthesis. Colforsin 0-9 interferon gamma Mus musculus 94-103 19195485-7 2009 The rescue of IFN-gamma production by Rp-8-Br-cAMPS was also observed in the inhibition by rolipram and forskolin. Colforsin 104-113 interferon gamma Mus musculus 14-23 19101612-2 2009 SH-EP1 cells transfected with DNAs coding for human alpha4 and/or beta2 subunits were incubated with (32)Pi, and PKA or PKC was activated by forskolin or phorbol 12,13-dibutyrate, respectively. Colforsin 141-150 immunoglobulin binding protein 1 Homo sapiens 52-63 19187565-6 2009 Inhibition of meiosis resumption by forskolin treatment prevented translocation of CDC2 to this ERES cluster. Colforsin 36-45 cyclin dependent kinase 1 Homo sapiens 83-87 19187565-8 2009 After removal of forskolin from the culture media, the transient translocation of CDC2 to ERES was accompanied by a transient dispersion of P-GM130 into the ER suggesting a role for CDC2 in redistributing Golgi components that have collapsed into ERES further into the ER during meiosis. Colforsin 17-26 cyclin dependent kinase 1 Homo sapiens 82-86 19074559-6 2009 Exposure of HBE monolayers to IL-17A for 48 h induced a novel forskolin-stimulated bicarbonate secretion in addition to forskolin-stimulated chloride secretion and resulted in alkalinization of liquid on the mucosal surface of polarized cells. Colforsin 62-71 interleukin 17A Homo sapiens 30-36 19074559-6 2009 Exposure of HBE monolayers to IL-17A for 48 h induced a novel forskolin-stimulated bicarbonate secretion in addition to forskolin-stimulated chloride secretion and resulted in alkalinization of liquid on the mucosal surface of polarized cells. Colforsin 120-129 interleukin 17A Homo sapiens 30-36 19176384-8 2009 Phosphorylation of ERK1/2 was PKA-independently inhibited by forskolin but not inhibited by Epac/Rap1 signaling, PKA modulation, or GPCR ligands. Colforsin 61-70 mitogen-activated protein kinase 3 Homo sapiens 19-25 19099187-5 2009 We also highlighted a role of cAMP in the pathway, because forskolin mimicked the effects of luzindole and/or PGE(2) in the RORalpha expression. Colforsin 59-68 RAR related orphan receptor A Homo sapiens 124-132 19176384-9 2009 Furthermore, the forskolin also inhibited phosphatidyl inositol-3-kinase (PI3K)-mediated activation of protein kinase Akt, as monitored by Ser473 phosphorylation. Colforsin 17-26 AKT serine/threonine kinase 1 Homo sapiens 118-121 19176384-11 2009 Collectively, these data show that forskolin strongly inhibits VM through PKA-independent activation of Epac/Rap1, PKA-, and Epac-independent inactivation of ERK1/2 and inhibition of PI3K/Akt. Colforsin 35-44 Rap guanine nucleotide exchange factor 3 Homo sapiens 104-108 19176384-11 2009 Collectively, these data show that forskolin strongly inhibits VM through PKA-independent activation of Epac/Rap1, PKA-, and Epac-independent inactivation of ERK1/2 and inhibition of PI3K/Akt. Colforsin 35-44 RAB guanine nucleotide exchange factor 1 Homo sapiens 109-113 19176384-11 2009 Collectively, these data show that forskolin strongly inhibits VM through PKA-independent activation of Epac/Rap1, PKA-, and Epac-independent inactivation of ERK1/2 and inhibition of PI3K/Akt. Colforsin 35-44 Rap guanine nucleotide exchange factor 3 Homo sapiens 125-129 19176384-11 2009 Collectively, these data show that forskolin strongly inhibits VM through PKA-independent activation of Epac/Rap1, PKA-, and Epac-independent inactivation of ERK1/2 and inhibition of PI3K/Akt. Colforsin 35-44 mitogen-activated protein kinase 3 Homo sapiens 158-164 19176384-11 2009 Collectively, these data show that forskolin strongly inhibits VM through PKA-independent activation of Epac/Rap1, PKA-, and Epac-independent inactivation of ERK1/2 and inhibition of PI3K/Akt. Colforsin 35-44 AKT serine/threonine kinase 1 Homo sapiens 188-191 18936144-5 2009 The effects of the adenylate cyclase agonist forskolin (FSK; 2 microM) on TGFbeta1 (5 ng/mL)-induced alpha-smooth muscle actin (alpha-SMA) expression was examined by immunofluorescence, flow cytometry, and immunochemistry 72 hours after treatment. Colforsin 45-54 actin, aortic smooth muscle Oryctolagus cuniculus 101-126 19082577-8 2009 In primary cultures, GIP release was stimulated by glucose, glutamine and linoleic acid, and potentiated by forskolin plus 3-isobutyl-1-methylxanthine (IBMX), but was unaffected by the artificial sweetener sucralose. Colforsin 108-117 gastric inhibitory polypeptide Mus musculus 21-24 18987998-6 2009 cAMP/PKA signaling activators PTH(1-31), forskolin and dibutyryl cAMP (db-cAMP), and calcium ionophore A23187 all increased OCIL levels. Colforsin 41-50 C-type lectin domain family 2, member D Rattus norvegicus 124-128 19276460-13 2009 The effects of forskolin, HCT 1026, NCX 2111 and SNP were paralleled by an increase in cyclic AMP or cyclic GMP. Colforsin 15-24 5'-nucleotidase, cytosolic II Homo sapiens 108-111 18936144-5 2009 The effects of the adenylate cyclase agonist forskolin (FSK; 2 microM) on TGFbeta1 (5 ng/mL)-induced alpha-smooth muscle actin (alpha-SMA) expression was examined by immunofluorescence, flow cytometry, and immunochemistry 72 hours after treatment. Colforsin 45-54 actin, aortic smooth muscle Oryctolagus cuniculus 128-137 18936144-5 2009 The effects of the adenylate cyclase agonist forskolin (FSK; 2 microM) on TGFbeta1 (5 ng/mL)-induced alpha-smooth muscle actin (alpha-SMA) expression was examined by immunofluorescence, flow cytometry, and immunochemistry 72 hours after treatment. Colforsin 56-59 actin, aortic smooth muscle Oryctolagus cuniculus 101-126 18936144-5 2009 The effects of the adenylate cyclase agonist forskolin (FSK; 2 microM) on TGFbeta1 (5 ng/mL)-induced alpha-smooth muscle actin (alpha-SMA) expression was examined by immunofluorescence, flow cytometry, and immunochemistry 72 hours after treatment. Colforsin 56-59 actin, aortic smooth muscle Oryctolagus cuniculus 128-137 18936144-6 2009 The effects of TGFbeta+FSK on activated pSmad3, CREB binding protein (CBP), MAPKs, and RhoA were determined by coimmunoprecipitation and Western blot. Colforsin 23-26 LOW QUALITY PROTEIN: CREB-binding protein Oryctolagus cuniculus 48-68 18936144-7 2009 RESULTS: FSK significantly reduced the myofibroblast phenotype and alpha-SMA expression induced by TGFbeta1 in rabbit corneal keratocytes. Colforsin 9-12 actin, aortic smooth muscle Oryctolagus cuniculus 67-76 18936144-11 2009 Activation of RhoA was significantly reduced by FSK. Colforsin 48-51 transforming protein RhoA Oryctolagus cuniculus 14-18 18936144-12 2009 CONCLUSIONS: Raising cAMP by FSK treatment inhibits the TGFbeta1-induced corneal myofibroblast transformation and alpha-SMA expression and thereby provides a promising method to control corneal fibrosis. Colforsin 29-32 actin, aortic smooth muscle Oryctolagus cuniculus 114-123 18854429-4 2009 Using a dominant-negative Epac-2 expression plasmid (Epac-2DN), we found that Epac inhibition attenuated forskolin-stimulated gcg promoter expression in the PKA-active STC-1 cell line and blocked forskolin-stimulated gcg promoter expression in the InR1-G9 cells. Colforsin 105-114 glucagon Cricetulus griseus 126-129 19121070-7 2009 RESULTS: The results showed that A. actinomycetemcomitans lipopolysaccharide stimulated both iNOS activity and nitrite production by HOS cells; this was reduced by l-NIL, anti-CD14, or anti-TLR4 antibody, SQ22536, KT5720, genistein, bisindolylmaleimde, BPB, and NDGA, but was enhanced by db-cAMP, IBMX, and forskolin. Colforsin 307-316 nitric oxide synthase 2 Homo sapiens 93-97 19091402-0 2009 Regulation of protein expression and function of octn2 in forskolin-induced syncytialization in BeWo Cells. Colforsin 58-67 solute carrier family 22 member 5 Homo sapiens 49-54 19091402-4 2009 Given that forskolin induces BeWo cells to undergo biochemical and morphological differentiation, the purpose of the present study was to investigate whether the function and expression of OCTN2 are influenced by forskolin treatment during syncytialization. Colforsin 213-222 solute carrier family 22 member 5 Homo sapiens 189-194 19091402-10 2009 OCTN2 protein expression was upregulated in isolated brush-border membranes by long-term forskolin treatment, but the V(m) for carnitine uptake was unchanged, although the K(m) increased. Colforsin 89-98 solute carrier family 22 member 5 Homo sapiens 0-5 19091402-11 2009 PDZK1, NHERF1 and NHERF2 protein expression in the brush-border membrane was downregulated by forskolin treatment, whereas PDZK2 levels remained unchanged. Colforsin 94-103 PDZ domain containing 1 Homo sapiens 0-5 19091402-11 2009 PDZK1, NHERF1 and NHERF2 protein expression in the brush-border membrane was downregulated by forskolin treatment, whereas PDZK2 levels remained unchanged. Colforsin 94-103 SLC9A3 regulator 1 Homo sapiens 7-13 19091402-11 2009 PDZK1, NHERF1 and NHERF2 protein expression in the brush-border membrane was downregulated by forskolin treatment, whereas PDZK2 levels remained unchanged. Colforsin 94-103 SLC9A3 regulator 2 Homo sapiens 18-24 19091402-12 2009 In conclusion, protein expression and function of OCTN2 in BeWo cells can be regulated by forskolin treatment. Colforsin 90-99 solute carrier family 22 member 5 Homo sapiens 50-55 19091402-13 2009 While the presence of forskolin results in an increase in OCTN2 protein expression, the increase in uptake capacity may be compensated by the decreased expression of PDZK1, NHERF1 or NHERF2. Colforsin 22-31 solute carrier family 22 member 5 Homo sapiens 58-63 19070599-7 2009 Expression of recombinant HDAC8 results in decreased CREB activation and CREB mediated gene transcription in response to forskolin application. Colforsin 121-130 histone deacetylase 8 Homo sapiens 26-31 19070599-7 2009 Expression of recombinant HDAC8 results in decreased CREB activation and CREB mediated gene transcription in response to forskolin application. Colforsin 121-130 cAMP responsive element binding protein 1 Homo sapiens 73-77 18992715-3 2009 Therefore, we studied the consequences of manipulating adenylyl cyclase activity with forskolin on the regulation of TH gene transcription in neuroblastoma cells (N1E-115). Colforsin 86-95 tyrosine hydroxylase Homo sapiens 117-119 18971210-8 2009 AT1 receptor blockade attenuated V2R, pS256-AQP2, and G(s)alpha protein downregulation in IM and partially reversed the obstruction-induced inhibition of sodium fluoride- and forskolin-stimulated cAMP generation in inner medullary membrane fractions from BUO rats. Colforsin 175-184 angiotensin II receptor, type 1a Rattus norvegicus 0-3 18854429-4 2009 Using a dominant-negative Epac-2 expression plasmid (Epac-2DN), we found that Epac inhibition attenuated forskolin-stimulated gcg promoter expression in the PKA-active STC-1 cell line and blocked forskolin-stimulated gcg promoter expression in the InR1-G9 cells. Colforsin 105-114 stanniocalcin-1 Cricetulus griseus 168-173 18854429-4 2009 Using a dominant-negative Epac-2 expression plasmid (Epac-2DN), we found that Epac inhibition attenuated forskolin-stimulated gcg promoter expression in the PKA-active STC-1 cell line and blocked forskolin-stimulated gcg promoter expression in the InR1-G9 cells. Colforsin 105-114 glucagon Cricetulus griseus 217-220 19936037-5 2009 A variety of compounds which affect known members of the CREB pathway were identified as active, including twelve known phosphodiesterase (PDE) inhibitors, and forskolin, a known activator of adenylate cyclase, thus validating the assay"s performance. Colforsin 160-169 cAMP responsive element binding protein 1 Homo sapiens 57-61 19255508-11 2009 Treatment of apc(Min/+) and apc(+/+)mice with 5 microM forskolin 15 minutes prior to the experiment or increase in local K+-concentrations to 35 mM (replacing Na+/NMDG) significantly increased DeltapH/min and abrogated the differences between genotypes. Colforsin 55-64 APC, WNT signaling pathway regulator Mus musculus 13-16 19255508-11 2009 Treatment of apc(Min/+) and apc(+/+)mice with 5 microM forskolin 15 minutes prior to the experiment or increase in local K+-concentrations to 35 mM (replacing Na+/NMDG) significantly increased DeltapH/min and abrogated the differences between genotypes. Colforsin 55-64 APC, WNT signaling pathway regulator Mus musculus 28-31 19484198-7 2009 Cells exposed to forskolin display a transient increase in MK5 mRNA, despite their unaltered MK5 protein levels. Colforsin 17-26 MAP kinase-activated protein kinase 5 Mus musculus 59-62 19706989-3 2009 In this study, we surveyed the effects of glucocorticoid, insulin, and forskolin (used as a surrogate of glucagon) on the transcriptional activity of glucokinase (GK), phosphofructokinase-1 (PFK1), liver-type pyruvate kinase (LPK), and all the PDKs/PDPs isoform genes. Colforsin 71-80 phosphofructokinase, muscle Homo sapiens 168-189 19706989-3 2009 In this study, we surveyed the effects of glucocorticoid, insulin, and forskolin (used as a surrogate of glucagon) on the transcriptional activity of glucokinase (GK), phosphofructokinase-1 (PFK1), liver-type pyruvate kinase (LPK), and all the PDKs/PDPs isoform genes. Colforsin 71-80 phosphofructokinase, muscle Homo sapiens 191-195 19706989-3 2009 In this study, we surveyed the effects of glucocorticoid, insulin, and forskolin (used as a surrogate of glucagon) on the transcriptional activity of glucokinase (GK), phosphofructokinase-1 (PFK1), liver-type pyruvate kinase (LPK), and all the PDKs/PDPs isoform genes. Colforsin 71-80 pyruvate dehydrogenase kinase 4 Homo sapiens 244-248 19046328-7 2009 Importantly, the representative aptamer A2 can effectively bind the mammalian GluR1 that inhibited GluR1/GluR1-containing AMPA receptor trafficking to the cell surface and abrogated forskolin-stimulated phosphorylation at GluR1 Ser845 in both green fluorescent protein-GluR1-transfected human embryonic kidney cells and cultured rat cortical neurons. Colforsin 182-191 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 78-83 19337015-5 2009 Long-term treatment of ATC7-L with (Nle4,D-Phe7)-alpha MSH (NDP-alpha MSH) or forskolin as well as Agrp strongly reduced MC4-R level by more than 30%. Colforsin 78-87 melanocortin 4 receptor Mus musculus 121-126 19125815-10 2009 Nuclear body localization of LRH-1 was suppressed by forskolin and cholera toxin. Colforsin 53-62 nuclear receptor subfamily 5, group A, member 2 Rattus norvegicus 29-34 19433899-1 2009 To explore the role of protein kinase A (PKA) in regulating tau phosphorylation and spatial memory, we injected forskolin, an activator of PKA, at different concentrations into the rat brains. Colforsin 112-121 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 139-142 19433899-4 2009 Forskolin elevated cAMP and activated PKA in a dose-dependent manner. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 38-41 19433899-6 2009 These data suggest that the upregulation of PKA by forskolin to a certain level may activate PP-2A but that the latter can ameliorate the PKA-induced tau phosphorylation and memory impairment in the rats. Colforsin 51-60 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 44-47 19012750-8 2009 Meanwhile, synaptic transmission was elevated by application of forskolin, an adenylyl cyclase activator, both in EP2 KO and WT animals. Colforsin 64-73 prostaglandin E receptor 2 (subtype EP2) Mus musculus 114-117 19046328-7 2009 Importantly, the representative aptamer A2 can effectively bind the mammalian GluR1 that inhibited GluR1/GluR1-containing AMPA receptor trafficking to the cell surface and abrogated forskolin-stimulated phosphorylation at GluR1 Ser845 in both green fluorescent protein-GluR1-transfected human embryonic kidney cells and cultured rat cortical neurons. Colforsin 182-191 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 99-104 19046328-7 2009 Importantly, the representative aptamer A2 can effectively bind the mammalian GluR1 that inhibited GluR1/GluR1-containing AMPA receptor trafficking to the cell surface and abrogated forskolin-stimulated phosphorylation at GluR1 Ser845 in both green fluorescent protein-GluR1-transfected human embryonic kidney cells and cultured rat cortical neurons. Colforsin 182-191 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 99-104 19046328-7 2009 Importantly, the representative aptamer A2 can effectively bind the mammalian GluR1 that inhibited GluR1/GluR1-containing AMPA receptor trafficking to the cell surface and abrogated forskolin-stimulated phosphorylation at GluR1 Ser845 in both green fluorescent protein-GluR1-transfected human embryonic kidney cells and cultured rat cortical neurons. Colforsin 182-191 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 99-104 19046328-7 2009 Importantly, the representative aptamer A2 can effectively bind the mammalian GluR1 that inhibited GluR1/GluR1-containing AMPA receptor trafficking to the cell surface and abrogated forskolin-stimulated phosphorylation at GluR1 Ser845 in both green fluorescent protein-GluR1-transfected human embryonic kidney cells and cultured rat cortical neurons. Colforsin 182-191 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 99-104 18983503-6 2009 Indeed, insulin interfered with LPS-induced cAMP decrease and TF upregulation in a manner similar to an inhibitor of G(i) (pertussis toxin) and agents that raise cAMP (iloprost, forskolin, IBMX) reduced TF upregulation. Colforsin 178-187 insulin Homo sapiens 8-15 18755793-7 2008 Subsequent two-dimensional electrophoresis with immunoblotting of strip extracts showed a significant 2.6- and 2.1-fold increase in phosphorylated HSP20 (pHSP20) after forskolin (P < 0.01; n = 5) or rolipram treatment (P < 0.05; n = 4). Colforsin 168-177 heat shock protein family B (small) member 6 Homo sapiens 147-152 18936084-7 2009 Treatment with BMP6 (0, 2, 10, and 50 ng/ml) and activin A (0, 2, 10 and 50 ng/ml) under these conditions dose-dependently suppressed forskolin-induced progesterone (P4) secretion from both cell types without affecting cell number. Colforsin 134-143 bone morphogenetic protein 6 Bos taurus 15-19 18936084-8 2009 BMP6 reduced forskolin-stimulated upregulation of STAR mRNA and raised "basal" CYP17A1 mRNA level in theca-lutein cells without affecting expression of CYP11A1 or hydroxy-Delta-5-steroid dehydrogenase, 3 beta- and steroid Delta-isomerase 1 (HSD3B1). Colforsin 13-22 bone morphogenetic protein 6 Bos taurus 0-4 18936084-8 2009 BMP6 reduced forskolin-stimulated upregulation of STAR mRNA and raised "basal" CYP17A1 mRNA level in theca-lutein cells without affecting expression of CYP11A1 or hydroxy-Delta-5-steroid dehydrogenase, 3 beta- and steroid Delta-isomerase 1 (HSD3B1). Colforsin 13-22 steroidogenic acute regulatory protein Bos taurus 50-54 18936084-8 2009 BMP6 reduced forskolin-stimulated upregulation of STAR mRNA and raised "basal" CYP17A1 mRNA level in theca-lutein cells without affecting expression of CYP11A1 or hydroxy-Delta-5-steroid dehydrogenase, 3 beta- and steroid Delta-isomerase 1 (HSD3B1). Colforsin 13-22 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 79-86 18936084-8 2009 BMP6 reduced forskolin-stimulated upregulation of STAR mRNA and raised "basal" CYP17A1 mRNA level in theca-lutein cells without affecting expression of CYP11A1 or hydroxy-Delta-5-steroid dehydrogenase, 3 beta- and steroid Delta-isomerase 1 (HSD3B1). Colforsin 13-22 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Bos taurus 241-247 18936084-9 2009 In granulosa-lutein cells, STAR transcript abundance was not affected by BMP6, whereas forskolin-induced expression of CYP11A1, HSD3B1, CYP19A1 and oxytocin transcripts was reduced. Colforsin 87-96 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 119-126 18936084-9 2009 In granulosa-lutein cells, STAR transcript abundance was not affected by BMP6, whereas forskolin-induced expression of CYP11A1, HSD3B1, CYP19A1 and oxytocin transcripts was reduced. Colforsin 87-96 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Bos taurus 128-134 18936084-9 2009 In granulosa-lutein cells, STAR transcript abundance was not affected by BMP6, whereas forskolin-induced expression of CYP11A1, HSD3B1, CYP19A1 and oxytocin transcripts was reduced. Colforsin 87-96 aromatase Bos taurus 136-143 18936084-10 2009 In both cell types, follistatin attenuated the suppressive effect of activin A and BMP6 on forskolin-induced P4 secretion but had no effect alone. Colforsin 91-100 bone morphogenetic protein 6 Bos taurus 83-87 18936091-8 2008 ER stress-induced mitochondrial dysfunction and apoptosis are also inhibited by forskolin, as well as by inactivation of iPLA(2)beta or NSMase, suggesting that iPLA(2)beta-mediated generation of ceramides via sphingomyelin hydrolysis during ER stress affect the mitochondria. Colforsin 80-89 phospholipase A2 group VI Rattus norvegicus 160-171 18181018-6 2008 Aromatase is expressed in SGBS cells and its expression and activity are strongly stimulated by forskolin (FSK) and phorbol 12-myristate-13-acetate (PMA) treatment. Colforsin 96-105 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 0-9 18181018-6 2008 Aromatase is expressed in SGBS cells and its expression and activity are strongly stimulated by forskolin (FSK) and phorbol 12-myristate-13-acetate (PMA) treatment. Colforsin 107-110 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 0-9 18181018-7 2008 Consistent with this, FSK and PMA treatment also increased activation of the proximal aromatase promoter, promoter II. Colforsin 22-25 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 86-95 18687781-6 2008 Overexpression of dominant-negative AP1 and activating transcription factor/cAMP response element-binding protein (CREB) inhibited forskolin-inducible promoter activity. Colforsin 131-140 Jun proto-oncogene, AP-1 transcription factor subunit Bos taurus 36-39 18687781-6 2008 Overexpression of dominant-negative AP1 and activating transcription factor/cAMP response element-binding protein (CREB) inhibited forskolin-inducible promoter activity. Colforsin 131-140 cAMP responsive element binding protein 1 Bos taurus 115-119 18687781-9 2008 Treatment with forskolin, prostaglandin E2, and catalytic subunit protein kinase (cPKA) stimulated, but H89, PKA inhibitor peptide, and indomethacin inhibited, TNFAIP6 promoter activity and gene expression in granulosa cells. Colforsin 15-24 TNF alpha induced protein 6 Bos taurus 160-167 19246974-6 2008 Protein kinase A, protein kinase C, and p38 mitogen-activated protein kinase pathways contributed to forskolin-induced transcriptional activity of CRF in hypothalamic 4B cells. Colforsin 101-110 mitogen-activated protein kinase 14 Homo sapiens 40-43 18981317-7 2008 Blockade of cell lysate renin activity ranged from 27+/-15% to 79+/-5%, and these percentages were identical for the renin that was released by forskolin, indicating that they represented the same renin pool, ie, the renin storage granules. Colforsin 144-153 renin Homo sapiens 117-122 18981317-7 2008 Blockade of cell lysate renin activity ranged from 27+/-15% to 79+/-5%, and these percentages were identical for the renin that was released by forskolin, indicating that they represented the same renin pool, ie, the renin storage granules. Colforsin 144-153 renin Homo sapiens 117-122 18981317-7 2008 Blockade of cell lysate renin activity ranged from 27+/-15% to 79+/-5%, and these percentages were identical for the renin that was released by forskolin, indicating that they represented the same renin pool, ie, the renin storage granules. Colforsin 144-153 renin Homo sapiens 117-122 18809381-7 2008 We observed that 16.7 mM glucose induces Ins2 mRNA, while forskolin and a Glp-1 agonist, exendin-4, induce a biphasic Ins2 mRNA response in mHypoE-39 neurons. Colforsin 58-67 insulin II Mus musculus 118-122 18957052-4 2008 Human neuroblastoma cells, IMR-32 induced to differentiate by serum starvation or by treatment with nerve growth factor (NGF) or forskolin showed enhanced C3G protein levels. Colforsin 129-138 Rap guanine nucleotide exchange factor 1 Homo sapiens 155-158 18957052-7 2008 Knockdown of C3G using small hairpin RNA inhibited forskolin and NGF-induced morphological differentiation of IMR-32 cells. Colforsin 51-60 Rap guanine nucleotide exchange factor 1 Homo sapiens 13-16 18957052-8 2008 Forskolin-induced differentiation was dependent on catalytic activity of C3G. Colforsin 0-9 Rap guanine nucleotide exchange factor 1 Homo sapiens 73-76 18957052-9 2008 Forskolin and NGF treatment resulted in phosphorylation of C3G at Tyr504 predominantly in the Golgi. Colforsin 0-9 Rap guanine nucleotide exchange factor 1 Homo sapiens 59-62 19008911-6 2008 Forskolin-mediated phosphorylation of AQP2, transiently expressed in COS cells, was increased by AKAP220 co-expression. Colforsin 0-9 aquaporin 2 Homo sapiens 38-42 19008911-6 2008 Forskolin-mediated phosphorylation of AQP2, transiently expressed in COS cells, was increased by AKAP220 co-expression. Colforsin 0-9 A-kinase anchoring protein 11 Homo sapiens 97-104 18851973-8 2008 This treatment caused an increase of both ANP mRNA and protein levels, which was almost completely abolished by FSK treatment. Colforsin 112-115 natriuretic peptide type A Mus musculus 42-45 18791066-11 2008 Calcium depletion and forskolin treatment caused activation of Rho, as evidenced by their translocation to the membrane, an event concurrent to Rac and RhoGDI translocation, and this effect was also reverted by H-89. Colforsin 22-31 AKT serine/threonine kinase 1 Homo sapiens 144-147 18791066-11 2008 Calcium depletion and forskolin treatment caused activation of Rho, as evidenced by their translocation to the membrane, an event concurrent to Rac and RhoGDI translocation, and this effect was also reverted by H-89. Colforsin 22-31 Rho GDP dissociation inhibitor alpha Homo sapiens 152-158 19967070-0 2008 Forskolin Enhances Synaptic Transmission in Rat Dorsal Striatum through NMDA Receptors and PKA in Different Phases. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 91-94 19967070-5 2008 When KT 5720 (5 microM), a protein kinase A (PKA) inhibitor, was applied through the patch pipette, forskolin (10 microM) increased corticostriatal EPSCs, but this increase was not maintained. Colforsin 100-109 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 27-43 19967070-5 2008 When KT 5720 (5 microM), a protein kinase A (PKA) inhibitor, was applied through the patch pipette, forskolin (10 microM) increased corticostriatal EPSCs, but this increase was not maintained. Colforsin 100-109 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 45-48 19967070-7 2008 These results suggest that forskolin activates both NMDA receptors and PKA, however, in a different manner. Colforsin 27-36 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 71-74 18650494-5 2008 The expression of syncytin 2 gene was decreased in preeclamptic placentas and could be stimulated by the cAMP stimulant forskolin. Colforsin 120-129 endogenous retrovirus group FRD member 1, envelope Homo sapiens 18-28 18988732-7 2008 Remarkably, a real-time quantitative RT-PCR analysis of MFSD2 in various human tissues demonstrates specific expression in the placenta, as well as in the human BeWo choriocarcinoma cell line, which discloses enhancement of receptor expression upon induction by forskolin of cell-cell fusion and syncytium formation. Colforsin 262-271 major facilitator superfamily domain containing 2A Homo sapiens 56-61 18768761-6 2008 Furthermore, norepinephrine and forskolin were able to synchronize circadian rhythms in bmal1. Colforsin 32-41 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 88-93 18975308-10 2008 The cAMP-elevating agents 8-Br-cAMP and forskolin suppressed IL-1-induced MMP-1 and MMP-13 expression, and the PKA inhibitors KT5720 and H89 reversed the inhibitory effect of PGD2, suggesting that the effect of PGD2 is mediated by the cAMP/PKA pathway. Colforsin 40-49 matrix metallopeptidase 1 Homo sapiens 74-79 18975308-10 2008 The cAMP-elevating agents 8-Br-cAMP and forskolin suppressed IL-1-induced MMP-1 and MMP-13 expression, and the PKA inhibitors KT5720 and H89 reversed the inhibitory effect of PGD2, suggesting that the effect of PGD2 is mediated by the cAMP/PKA pathway. Colforsin 40-49 matrix metallopeptidase 13 Homo sapiens 84-90 18599477-7 2008 Elevation of endogenous adenosine 3",5"-cyclic monophosphate (cAMP) with forskolin-inhibited Rac(1) activity, reduced Skp2, increased p27(Kip1) and inhibited VSMC proliferation, effects that were reversed by constitutively active Rac(1). Colforsin 73-82 Rac family small GTPase 1 Rattus norvegicus 93-99 18599477-7 2008 Elevation of endogenous adenosine 3",5"-cyclic monophosphate (cAMP) with forskolin-inhibited Rac(1) activity, reduced Skp2, increased p27(Kip1) and inhibited VSMC proliferation, effects that were reversed by constitutively active Rac(1). Colforsin 73-82 S-phase kinase associated protein 2 Rattus norvegicus 118-122 18599477-7 2008 Elevation of endogenous adenosine 3",5"-cyclic monophosphate (cAMP) with forskolin-inhibited Rac(1) activity, reduced Skp2, increased p27(Kip1) and inhibited VSMC proliferation, effects that were reversed by constitutively active Rac(1). Colforsin 73-82 cyclin-dependent kinase inhibitor 1B Rattus norvegicus 134-137 18599477-7 2008 Elevation of endogenous adenosine 3",5"-cyclic monophosphate (cAMP) with forskolin-inhibited Rac(1) activity, reduced Skp2, increased p27(Kip1) and inhibited VSMC proliferation, effects that were reversed by constitutively active Rac(1). Colforsin 73-82 cyclin-dependent kinase inhibitor 1B Rattus norvegicus 138-142 18599477-7 2008 Elevation of endogenous adenosine 3",5"-cyclic monophosphate (cAMP) with forskolin-inhibited Rac(1) activity, reduced Skp2, increased p27(Kip1) and inhibited VSMC proliferation, effects that were reversed by constitutively active Rac(1). Colforsin 73-82 Rac family small GTPase 1 Rattus norvegicus 230-236 18762248-5 2008 PGE(2)-induced COX-2 induction was abrogated by inhibition of either p38 MAPK or AMP activated protein kinase (AMPK), and was mimicked by AICAR, a selective AMPK activator, and by the cAMP-elevating agents, forskolin (FSK) and IBMX. Colforsin 207-216 prostaglandin-endoperoxide synthase 2 Mus musculus 15-20 18762248-5 2008 PGE(2)-induced COX-2 induction was abrogated by inhibition of either p38 MAPK or AMP activated protein kinase (AMPK), and was mimicked by AICAR, a selective AMPK activator, and by the cAMP-elevating agents, forskolin (FSK) and IBMX. Colforsin 218-221 prostaglandin-endoperoxide synthase 2 Mus musculus 15-20 18949369-11 2008 Induction of Nur77 expression was stimulated on treatment of cells with forskolin and 8-Br-cAMP, whereas H-89, a specific inhibitor of PKA pathway significantly inhibited GnRHA-induced Nur77 expression. Colforsin 72-81 nuclear receptor subfamily 4, group A, member 1 Mus musculus 13-18 18374612-2 2008 Ex-vivo, GCH1 upregulation and BH4 production after forskolin stimulation were reduced, while baseline BH4 concentrations were not affected. Colforsin 52-61 GTP cyclohydrolase 1 Homo sapiens 9-13 18491045-7 2008 The study with the use of forskolin and dibutyryl-cAMP revealed that the growth effects of PACAP were cAMP independent. Colforsin 26-35 adenylate cyclase activating polypeptide 1 Homo sapiens 91-96 19014362-4 2008 A forskolin-induced increase in cAMP in ovo inhibited longitudinal growth by sensory afferents. Colforsin 2-11 cathelicidin-2 Gallus gallus 32-36 18773429-8 2008 beta-Glucuronidase secretion from isolated intestinal epithelial cells was significantly increased by treatment with 1,25(OH)2D3, PTH, or forskolin, but not by phorbol ester. Colforsin 138-147 glucuronidase beta Gallus gallus 0-18 18752581-3 2008 METHODS: The function of wild-type and mutant P2Y(12) receptors stably expressed in Chinese hamster ovary cells was assessed by measuring the 2-methylthio-ADP-mediated inhibition of forskolin-stimulated cellular cAMP production. Colforsin 182-191 purinergic receptor P2Y12 Homo sapiens 46-53 18642057-2 2008 Inhibition of Src with PP2 increased both basal and forskolin-stimulated androstenedione secretion, and increased cytochrome P450 17-alpha hydroxylase-lyase (CYP17) promoter activity and steady state mRNA. Colforsin 52-61 Rous sarcoma oncogene Mus musculus 14-17 18642057-2 2008 Inhibition of Src with PP2 increased both basal and forskolin-stimulated androstenedione secretion, and increased cytochrome P450 17-alpha hydroxylase-lyase (CYP17) promoter activity and steady state mRNA. Colforsin 52-61 neuropeptide Y receptor Y6 Mus musculus 23-26 18642057-4 2008 Inhibition of mitogen-activated protein kinase kinase, a downstream regulator of Src activity, using PD98059 also increased forskolin-stimulated secretion of androstenedione above forskolin alone, but had no effect on basal secretion of androstenedione. Colforsin 124-133 Rous sarcoma oncogene Mus musculus 81-84 18642057-4 2008 Inhibition of mitogen-activated protein kinase kinase, a downstream regulator of Src activity, using PD98059 also increased forskolin-stimulated secretion of androstenedione above forskolin alone, but had no effect on basal secretion of androstenedione. Colforsin 180-189 Rous sarcoma oncogene Mus musculus 81-84 19010824-7 2008 Forskolin and 8Br-cAMP also up-regulated ErbB-2 in both LHR-expressing and mock-transfected cells, indicating that regulation of ErbB-2 is a cAMP-mediated event. Colforsin 0-9 erb-b2 receptor tyrosine kinase 2 Homo sapiens 41-47 19010824-7 2008 Forskolin and 8Br-cAMP also up-regulated ErbB-2 in both LHR-expressing and mock-transfected cells, indicating that regulation of ErbB-2 is a cAMP-mediated event. Colforsin 0-9 luteinizing hormone/choriogonadotropin receptor Homo sapiens 56-59 19010824-7 2008 Forskolin and 8Br-cAMP also up-regulated ErbB-2 in both LHR-expressing and mock-transfected cells, indicating that regulation of ErbB-2 is a cAMP-mediated event. Colforsin 0-9 erb-b2 receptor tyrosine kinase 2 Homo sapiens 129-135 18717811-8 2008 The activity of PACAP was inhibited by the protein kinase A inhibitor N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide dihydrochloride, as was the case with the activity of forskolin, suggesting downstream involvement of a cAMP-protein kinase A signaling pathway. Colforsin 185-194 adenylate cyclase activating polypeptide 1 Rattus norvegicus 16-21 18705646-4 2008 Upon activation, the MT1 receptor specifically couples to the G(alphai2), G(alphai3), G(alphaq), and G(alphall) proteins, and via activation of G(alphai2) proteins, melatonin suppresses forskolin-induced 3",5"-cyclic adenosine monophosphate production, while melatonin activation of G(alphaq), is able to inhibit phospholipid hydrolysis and ATP"s induction of inositol triphosphate production in MCF-7 breast cancer cells. Colforsin 186-195 metallothionein 1I, pseudogene Homo sapiens 21-24 18468883-10 2008 The inhibitory effect of hNPY can be washed out and the same cells can be stimulated by forskolin again. Colforsin 88-97 neuropeptide Y Homo sapiens 25-29 18619496-6 2008 The inhibitory effect of somatostatin in lipopolysaccharide-treated cells could be mimicked by protein kinase A inhibitor and was prevented by forskolin. Colforsin 143-152 somatostatin Rattus norvegicus 25-37 18755809-11 2008 The induction required suppression of protein kinase A (PKA) since forskolin treatment suppressed menin protein levels and octreotide inhibited PKA enzyme activity. Colforsin 67-76 multiple endocrine neoplasia 1 Mus musculus 98-103 18647802-9 2008 The cAMP elevating compound forskolin increased PRL release in both cell types. Colforsin 28-37 prolactin Homo sapiens 48-51 18658272-6 2008 Flagellin-, IL-1beta-, ATP-, and forskolin-stimulated I(Cl) were inhibited by cystic fibrosis transmembrane conductance regulator (CFTR) blockers GlyH101, CFTRinh172, and glibenclamide. Colforsin 33-42 CF transmembrane conductance regulator Homo sapiens 78-129 18658272-6 2008 Flagellin-, IL-1beta-, ATP-, and forskolin-stimulated I(Cl) were inhibited by cystic fibrosis transmembrane conductance regulator (CFTR) blockers GlyH101, CFTRinh172, and glibenclamide. Colforsin 33-42 CF transmembrane conductance regulator Homo sapiens 131-135 18619673-5 2008 (Met)enkephalin production was stimulated by up to 2-fold by forskolin treatment, but not by PMA. Colforsin 61-70 proopiomelanocortin Homo sapiens 1-15 18680557-6 2008 ADA also increases the ability of the agonist to decrease the forskolin-induced cAMP levels. Colforsin 62-71 adenosine deaminase Homo sapiens 0-3 18647223-9 2008 Both forskolin and histamine induced regulated release of t-PA. Colforsin 5-14 plasminogen activator, tissue type Homo sapiens 58-62 18619673-7 2008 Notably, VIP production was highly stimulated by forskolin and PMA, with increases of 3-fold and 10-15-fold, respectively. Colforsin 49-58 vasoactive intestinal peptide Homo sapiens 9-12 18586956-8 2008 Activation of cAMP/PKA cascade by forskolin, which has a barrier-protective effect against thrombin-induced EC permeability, attenuates thrombin-induced phosphorylation of moesin at the cell periphery of control siRNA-treated EC. Colforsin 34-43 coagulation factor II, thrombin Homo sapiens 91-99 18514641-3 2008 Upon the treatment of dibutyryl-cAMP (Bt(2)-cAMP) and forskolin in cultured cells to stimulate the cAMP-dependent signaling pathway, the mRNA expressions of both AChE(T) and PRiMA I, as well as the enzymatic activity were up-regulated. Colforsin 54-63 acetylcholinesterase Rattus norvegicus 162-166 18514641-3 2008 Upon the treatment of dibutyryl-cAMP (Bt(2)-cAMP) and forskolin in cultured cells to stimulate the cAMP-dependent signaling pathway, the mRNA expressions of both AChE(T) and PRiMA I, as well as the enzymatic activity were up-regulated. Colforsin 54-63 proline rich membrane anchor 1 Rattus norvegicus 174-179 18586957-2 2008 In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells. Colforsin 30-39 intercellular adhesion molecule 1 Homo sapiens 171-177 18586957-2 2008 In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells. Colforsin 30-39 colony stimulating factor 2 Homo sapiens 197-203 18655772-5 2008 Treatment of primary murine aortic cells with the PKA activator, forskolin, significantly induced osteoblastic differentiation markers, including alkaline phosphatase (ALP), osteopontin, and osteocalcin as well as the pyrophosphate generator, ectonucleotide-pyrophosphatase/phosphodiesterase-1 (Enpp1) and the pyrophosphate transporter, ankylosis protein, but not the sodium/phosphate cotransporter, Pit-1. Colforsin 65-74 secreted phosphoprotein 1 Mus musculus 174-185 18655772-5 2008 Treatment of primary murine aortic cells with the PKA activator, forskolin, significantly induced osteoblastic differentiation markers, including alkaline phosphatase (ALP), osteopontin, and osteocalcin as well as the pyrophosphate generator, ectonucleotide-pyrophosphatase/phosphodiesterase-1 (Enpp1) and the pyrophosphate transporter, ankylosis protein, but not the sodium/phosphate cotransporter, Pit-1. Colforsin 65-74 bone gamma-carboxyglutamate protein 2 Mus musculus 191-202 18655772-5 2008 Treatment of primary murine aortic cells with the PKA activator, forskolin, significantly induced osteoblastic differentiation markers, including alkaline phosphatase (ALP), osteopontin, and osteocalcin as well as the pyrophosphate generator, ectonucleotide-pyrophosphatase/phosphodiesterase-1 (Enpp1) and the pyrophosphate transporter, ankylosis protein, but not the sodium/phosphate cotransporter, Pit-1. Colforsin 65-74 ectonucleotide pyrophosphatase/phosphodiesterase 1 Mus musculus 243-293 18655772-5 2008 Treatment of primary murine aortic cells with the PKA activator, forskolin, significantly induced osteoblastic differentiation markers, including alkaline phosphatase (ALP), osteopontin, and osteocalcin as well as the pyrophosphate generator, ectonucleotide-pyrophosphatase/phosphodiesterase-1 (Enpp1) and the pyrophosphate transporter, ankylosis protein, but not the sodium/phosphate cotransporter, Pit-1. Colforsin 65-74 ectonucleotide pyrophosphatase/phosphodiesterase 1 Mus musculus 295-300 18655772-5 2008 Treatment of primary murine aortic cells with the PKA activator, forskolin, significantly induced osteoblastic differentiation markers, including alkaline phosphatase (ALP), osteopontin, and osteocalcin as well as the pyrophosphate generator, ectonucleotide-pyrophosphatase/phosphodiesterase-1 (Enpp1) and the pyrophosphate transporter, ankylosis protein, but not the sodium/phosphate cotransporter, Pit-1. Colforsin 65-74 POU domain, class 1, transcription factor 1 Mus musculus 400-405 18655772-7 2008 Inhibitors of ALP or Pit-1 abrogated forskolin-induced osteopontin expression and mineralization but not forskolin-induced osteocalcin or ALP. Colforsin 37-46 POU domain, class 1, transcription factor 1 Mus musculus 21-26 18655772-7 2008 Inhibitors of ALP or Pit-1 abrogated forskolin-induced osteopontin expression and mineralization but not forskolin-induced osteocalcin or ALP. Colforsin 37-46 secreted phosphoprotein 1 Mus musculus 55-66 18566450-9 2008 Frmpd1 knockdown (siRNA) in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by approximately 50% and enhanced the alpha2-adrenergic receptor-mediated inhibition of forskolin-induced increases in cAMP. Colforsin 214-223 FERM and PDZ domain containing 1 Mus musculus 0-6 18496024-1 2008 BACKGROUND: Immunomodulators such as lipopolysaccharides (LPS) and forskolin change the nature of dendritic cells (DCs) to induce Th1 and Th2 cells, respectively, thereby designated Th1 or Th2 adjuvants. Colforsin 67-76 negative elongation factor complex member C/D Homo sapiens 130-133 18496024-1 2008 BACKGROUND: Immunomodulators such as lipopolysaccharides (LPS) and forskolin change the nature of dendritic cells (DCs) to induce Th1 and Th2 cells, respectively, thereby designated Th1 or Th2 adjuvants. Colforsin 67-76 negative elongation factor complex member C/D Homo sapiens 182-185 18496024-6 2008 RESULTS: Th2 adjuvant forskolin was qualitatively evaluated by an increased expression of Delta1 in PMA-treated THP-1 cells, as reported in our previous study. Colforsin 22-31 delta like non-canonical Notch ligand 1 Homo sapiens 90-96 18496024-6 2008 RESULTS: Th2 adjuvant forskolin was qualitatively evaluated by an increased expression of Delta1 in PMA-treated THP-1 cells, as reported in our previous study. Colforsin 22-31 GLI family zinc finger 2 Homo sapiens 112-117 18496024-7 2008 In PMA-treated THP-1 cells, intracellular cAMP levels increased after stimulation with forskolin, in a dose-dependent manner. Colforsin 87-96 GLI family zinc finger 2 Homo sapiens 15-20 18496024-9 2008 CONCLUSIONS: Th2- and Th1-adjuvant activities can be quantitatively evaluated by using PMA-treated THP-1 cells and PMA-treated/forskolin-stimulated THP-1 cells, respectively. Colforsin 127-136 negative elongation factor complex member C/D Homo sapiens 22-25 18496024-9 2008 CONCLUSIONS: Th2- and Th1-adjuvant activities can be quantitatively evaluated by using PMA-treated THP-1 cells and PMA-treated/forskolin-stimulated THP-1 cells, respectively. Colforsin 127-136 GLI family zinc finger 2 Homo sapiens 148-153 18586957-2 2008 In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells. Colforsin 30-39 interleukin 1 beta Homo sapiens 214-222 18586957-3 2008 IL-1beta-induced IL-8 release was also repressed by PGE(2) and forskolin, whereas the beta(2)-adrenoceptor agonists were ineffective. Colforsin 63-72 interleukin 1 beta Homo sapiens 0-8 18586957-3 2008 IL-1beta-induced IL-8 release was also repressed by PGE(2) and forskolin, whereas the beta(2)-adrenoceptor agonists were ineffective. Colforsin 63-72 C-X-C motif chemokine ligand 8 Homo sapiens 17-21 18586956-8 2008 Activation of cAMP/PKA cascade by forskolin, which has a barrier-protective effect against thrombin-induced EC permeability, attenuates thrombin-induced phosphorylation of moesin at the cell periphery of control siRNA-treated EC. Colforsin 34-43 coagulation factor II, thrombin Homo sapiens 136-144 18586956-8 2008 Activation of cAMP/PKA cascade by forskolin, which has a barrier-protective effect against thrombin-induced EC permeability, attenuates thrombin-induced phosphorylation of moesin at the cell periphery of control siRNA-treated EC. Colforsin 34-43 moesin Homo sapiens 172-178 18028952-0 2008 Induction of microphthalmia transcription factor (Mitf) by forskolin and stimulation of melanin release in UISO-Mel-6 cells. Colforsin 59-68 melanocyte inducing transcription factor Homo sapiens 13-48 18551429-6 2008 In addition, forskolin increases the TGF-beta1- and PMA-induced myofibroblast migration but inhibits TGF-beta1- and PMA-induced the expression of I(A) channels. Colforsin 13-22 transforming growth factor, beta 1 Rattus norvegicus 37-46 18551429-6 2008 In addition, forskolin increases the TGF-beta1- and PMA-induced myofibroblast migration but inhibits TGF-beta1- and PMA-induced the expression of I(A) channels. Colforsin 13-22 transforming growth factor, beta 1 Rattus norvegicus 101-110 18523159-8 2008 In contrast, the H(3)R-induced attenuation of cAMP accumulation and dopamine exocytosis in response to forskolin were the same in both PC12-H(3) and PC12-H(3)/beta-ARK1 cells. Colforsin 103-112 G protein-coupled receptor kinase 2 Rattus norvegicus 159-168 18624927-8 2008 Forskolin-stimulated CRH mRNA levels in the paraventricular nucleus were also inhibited by CORT or DEX in the presence and in the absence of TTX. Colforsin 0-9 corticotropin releasing hormone Rattus norvegicus 21-24 18624927-10 2008 Type II corticosteroid receptor agonists act directly on paraventricular neurones to inhibit basal and forskolin-induced CRH mRNA expression in explant cultures of the rat hypothalamus. Colforsin 103-112 corticotropin releasing hormone Rattus norvegicus 121-124 18028952-0 2008 Induction of microphthalmia transcription factor (Mitf) by forskolin and stimulation of melanin release in UISO-Mel-6 cells. Colforsin 59-68 melanocyte inducing transcription factor Homo sapiens 50-54 18028952-4 2008 Forskolin is a known alpha-melanocyte-stimulating hormone agonist. Colforsin 0-9 proopiomelanocortin Homo sapiens 21-57 18028952-6 2008 Forskolin inhibits cell proliferation and increases the expression of Mitf and tyrosinase related protein-1. Colforsin 0-9 melanocyte inducing transcription factor Homo sapiens 70-74 18028952-6 2008 Forskolin inhibits cell proliferation and increases the expression of Mitf and tyrosinase related protein-1. Colforsin 0-9 tyrosinase related protein 1 Homo sapiens 79-107 18028952-9 2008 Our results suggest that Forskolin induces differentiation in melanoma cells via Mitf pathway. Colforsin 25-34 melanocyte inducing transcription factor Homo sapiens 81-85 18505831-6 2008 We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). Colforsin 101-110 nuclear receptor subfamily 0 group B member 2 Homo sapiens 48-51 18590921-4 2008 Accordingly, the selective mGlu2/3 receptor agonist, LY379268 (1microM) reduced forskolin-stimulated cAMP formation by 56% and 32% in hippocampal slices from FRL and FSL rats, respectively. Colforsin 80-89 glutamate receptor, metabotropic 3 Mus musculus 27-34 18577515-5 2008 Stimulation with cholecystokinin (CCK), carbachol, and vasoactive intestinal peptide all induced Rap1 activation, as did calcium ionophore A23187, phorbol ester, forskolin, 8-bromo-cyclic AMP, and the Epac-specific cAMP analog 8-pCPT-2"-O-Me-cAMP. Colforsin 162-171 cholecystokinin Mus musculus 17-32 18577515-5 2008 Stimulation with cholecystokinin (CCK), carbachol, and vasoactive intestinal peptide all induced Rap1 activation, as did calcium ionophore A23187, phorbol ester, forskolin, 8-bromo-cyclic AMP, and the Epac-specific cAMP analog 8-pCPT-2"-O-Me-cAMP. Colforsin 162-171 cholecystokinin Mus musculus 34-37 18577515-5 2008 Stimulation with cholecystokinin (CCK), carbachol, and vasoactive intestinal peptide all induced Rap1 activation, as did calcium ionophore A23187, phorbol ester, forskolin, 8-bromo-cyclic AMP, and the Epac-specific cAMP analog 8-pCPT-2"-O-Me-cAMP. Colforsin 162-171 RAS-related protein 1a Mus musculus 97-101 18577515-8 2008 Although the protein kinase A inhibitor H-89 abolished forskolin-stimulated CREB phosphorylation, it did not modify forskolin-induced GTP-Rap1 levels, excluding PKA participation. Colforsin 55-64 cAMP responsive element binding protein 1 Mus musculus 76-80 18426392-7 2008 Thirdly, we show that RNAi (RNA interference) targeting hGSTA3-3 expression decreases by 30% the forskolin-stimulated production of the steroid hormone progesterone in a human placental cell line. Colforsin 97-106 glutathione S-transferase alpha 3 Homo sapiens 56-62 18534624-4 2008 Furthermore, forskolin, an activator of cAMP, recovered the CSF IgG-induced reduction of GABA release. Colforsin 13-22 colony stimulating factor 2 Rattus norvegicus 60-63 18685024-3 2008 Using low-frequency (0.2 Hz) electrophysiological recordings in the presence of the Epac-selective cAMP analog 8-pCPT-2"-O-Me-cAMP (ESCA(1)), we find that Epac activation by this analog accounts on average for 38% of the forskolin-induced increase in evoked EPSC amplitudes and for 100% of the forskolin-induced increase in miniature EPSC (mEPSC) frequency in dissociated autaptic neuronal cultures from mouse hippocampus. Colforsin 221-230 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 84-88 18685024-3 2008 Using low-frequency (0.2 Hz) electrophysiological recordings in the presence of the Epac-selective cAMP analog 8-pCPT-2"-O-Me-cAMP (ESCA(1)), we find that Epac activation by this analog accounts on average for 38% of the forskolin-induced increase in evoked EPSC amplitudes and for 100% of the forskolin-induced increase in miniature EPSC (mEPSC) frequency in dissociated autaptic neuronal cultures from mouse hippocampus. Colforsin 221-230 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 155-159 18685024-3 2008 Using low-frequency (0.2 Hz) electrophysiological recordings in the presence of the Epac-selective cAMP analog 8-pCPT-2"-O-Me-cAMP (ESCA(1)), we find that Epac activation by this analog accounts on average for 38% of the forskolin-induced increase in evoked EPSC amplitudes and for 100% of the forskolin-induced increase in miniature EPSC (mEPSC) frequency in dissociated autaptic neuronal cultures from mouse hippocampus. Colforsin 294-303 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 84-88 18685024-3 2008 Using low-frequency (0.2 Hz) electrophysiological recordings in the presence of the Epac-selective cAMP analog 8-pCPT-2"-O-Me-cAMP (ESCA(1)), we find that Epac activation by this analog accounts on average for 38% of the forskolin-induced increase in evoked EPSC amplitudes and for 100% of the forskolin-induced increase in miniature EPSC (mEPSC) frequency in dissociated autaptic neuronal cultures from mouse hippocampus. Colforsin 294-303 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 155-159 18338250-4 2008 We found that 17beta-estradiol effectively attenuated forskolin-induced overactivation of PKA and elevation of cAMP, and thus prevented tau from hyperphosphorylation. Colforsin 54-63 microtubule associated protein tau Homo sapiens 136-139 18621029-7 2008 Under these conditions, both MT1 and MT2 deficiencies prevented melatonin from inhibiting forskolin-stimulated cAMP levels and cFos immunoreactivity. Colforsin 90-99 metallothionein 1 Mus musculus 29-32 18621029-7 2008 Under these conditions, both MT1 and MT2 deficiencies prevented melatonin from inhibiting forskolin-stimulated cAMP levels and cFos immunoreactivity. Colforsin 90-99 metallothionein 2 Mus musculus 37-40 18505831-6 2008 We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). Colforsin 101-110 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 188-221 18505831-6 2008 We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). Colforsin 101-110 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 223-228 18505831-6 2008 We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). Colforsin 101-110 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 234-255 18505831-6 2008 We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). Colforsin 101-110 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 257-263 18505831-9 2008 The knockdown of SHP expression by oligonucleotide siRNA SHP or adenoviral siRNA SHP released the sodium arsenite-mediated repression of forskolin/dexamethasone-stimulated PEPCK and G6Pase gene expression in a variety of hepatic cell lines. Colforsin 137-146 nuclear receptor subfamily 0 group B member 2 Homo sapiens 17-20 18505831-9 2008 The knockdown of SHP expression by oligonucleotide siRNA SHP or adenoviral siRNA SHP released the sodium arsenite-mediated repression of forskolin/dexamethasone-stimulated PEPCK and G6Pase gene expression in a variety of hepatic cell lines. Colforsin 137-146 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 172-177 18505831-9 2008 The knockdown of SHP expression by oligonucleotide siRNA SHP or adenoviral siRNA SHP released the sodium arsenite-mediated repression of forskolin/dexamethasone-stimulated PEPCK and G6Pase gene expression in a variety of hepatic cell lines. Colforsin 137-146 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 182-188 18495429-4 2008 Recently, we reported PKA-independent activation of the protein kinase Akt as well co-immunoprecipitation of Epac1 with Rap1, p-Akt(Thr-308), and p-Akt(Ser-473) in forskolin-stimulated macrophages. Colforsin 164-173 Rap guanine nucleotide exchange factor 3 Homo sapiens 109-114 18187190-4 2008 In both 16HBE14o- and Caco-2 cells, forskolin (FSK) stimulated increased anx 2-S100A10 complex formation, which was attenuated by either PKA inhibitors or calcineurin A (CnA) inhibitors. Colforsin 36-45 annexin A2 Homo sapiens 73-78 18187190-4 2008 In both 16HBE14o- and Caco-2 cells, forskolin (FSK) stimulated increased anx 2-S100A10 complex formation, which was attenuated by either PKA inhibitors or calcineurin A (CnA) inhibitors. Colforsin 36-45 S100 calcium binding protein A10 Homo sapiens 79-86 18187190-4 2008 In both 16HBE14o- and Caco-2 cells, forskolin (FSK) stimulated increased anx 2-S100A10 complex formation, which was attenuated by either PKA inhibitors or calcineurin A (CnA) inhibitors. Colforsin 47-50 annexin A2 Homo sapiens 73-78 18547981-2 2008 Elevation of intracellular cAMP with forskolin decreased the cross-correlation amplitude between RFP-fused RII (RII-mRFP) and GFP-fused CAT (CAT-EGFP) by 50%, indicating that cAMP elevation leads to dissociation of RII-CAT complexes. Colforsin 37-46 catalase Homo sapiens 136-139 18187190-4 2008 In both 16HBE14o- and Caco-2 cells, forskolin (FSK) stimulated increased anx 2-S100A10 complex formation, which was attenuated by either PKA inhibitors or calcineurin A (CnA) inhibitors. Colforsin 47-50 S100 calcium binding protein A10 Homo sapiens 79-86 18187190-5 2008 The anx 2-S100A10 complex association with TRPV6 was dependent on FSK-induced CnA-dependent dephosphorylation of anx 2. Colforsin 66-69 annexin A2 Homo sapiens 4-9 18187190-5 2008 The anx 2-S100A10 complex association with TRPV6 was dependent on FSK-induced CnA-dependent dephosphorylation of anx 2. Colforsin 66-69 S100 calcium binding protein A10 Homo sapiens 10-17 18187190-5 2008 The anx 2-S100A10 complex association with TRPV6 was dependent on FSK-induced CnA-dependent dephosphorylation of anx 2. Colforsin 66-69 transient receptor potential cation channel subfamily V member 6 Homo sapiens 43-48 18187190-5 2008 The anx 2-S100A10 complex association with TRPV6 was dependent on FSK-induced CnA-dependent dephosphorylation of anx 2. Colforsin 66-69 annexin A2 Homo sapiens 113-118 18434435-7 2008 Inversely, when O-GlcNAc levels were reduced, using forskolin or glucose deprivation, ubiquitination decreased. Colforsin 52-61 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 16-24 18450967-9 2008 Interestingly, PTH and forskolin (adenylate cyclase/PKA pathway activator) treatment causes an increase in PLCbeta3 phosphorylation at the Ser1105 inhibitory site and that increase is blocked by the PKA inhibitor, H89. Colforsin 23-32 phospholipase C beta 3 Homo sapiens 107-115 18702688-3 2008 We show that triggering depolarization by potassium chloride or increasing the cellular cAMP by forskolin treatment led to elevated levels of expression and activity of mouse MK2. Colforsin 96-105 MAP kinase-activated protein kinase 2 Mus musculus 175-178 18466337-0 2008 Forskolin induction of late-LTP and up-regulation of 5" TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells. Colforsin 0-9 mechanistic target of rapamycin kinase Homo sapiens 82-86 18466337-0 2008 Forskolin induction of late-LTP and up-regulation of 5" TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 88-91 18466337-5 2008 Forskolin, an adenylate cyclase activator, induced L-LTP in organotypic slices that was mTOR-dependent. Colforsin 0-9 mechanistic target of rapamycin kinase Homo sapiens 88-92 18466337-9 2008 Our findings indicate that forskolin induces L-LTP in hippocampal neurons and up-regulates 5" TOP mRNAs translation via mTOR, suggesting that up-regulation of the translational machinery is a candidate mechanism for the stabilization of LTP. Colforsin 27-36 mechanistic target of rapamycin kinase Homo sapiens 120-124 18547981-2 2008 Elevation of intracellular cAMP with forskolin decreased the cross-correlation amplitude between RFP-fused RII (RII-mRFP) and GFP-fused CAT (CAT-EGFP) by 50%, indicating that cAMP elevation leads to dissociation of RII-CAT complexes. Colforsin 37-46 catalase Homo sapiens 141-149 18547981-2 2008 Elevation of intracellular cAMP with forskolin decreased the cross-correlation amplitude between RFP-fused RII (RII-mRFP) and GFP-fused CAT (CAT-EGFP) by 50%, indicating that cAMP elevation leads to dissociation of RII-CAT complexes. Colforsin 37-46 catalase Homo sapiens 141-144 18650329-5 2008 In hippocampal neurons, PKA activation with forskolin or 8-Br-cAMP induced Kv4.2 internalization from dendritic spines, whereas PKA inhibition with H89 prevented AMPA-induced internalization. Colforsin 44-53 potassium voltage-gated channel subfamily D member 2 Homo sapiens 75-80 18469159-4 2008 We examined the effects of cAMP analogs and the cAMP-elevating agents forskolin and beta2-agonists on lipopolysaccharide (LPS)-induced TTP mRNA and protein expression by quantitative real-time reverse transcriptase-polymerase chain reaction and Western blotting in activated macrophages. Colforsin 70-79 zinc finger protein 36 Mus musculus 135-138 18482991-4 2008 Using HEK cells stably expressing TRPV1 and the mu opioid receptor, we demonstrated that treatment with the adenylate cyclase activator forskolin significantly increased the multimeric TRPV1 species. Colforsin 136-145 transient receptor potential cation channel subfamily V member 1 Homo sapiens 34-39 18502031-9 2008 In addition, forskolin but not TPA stimulated Pcsk5 mRNA levels. Colforsin 13-22 proprotein convertase subtilisin/kexin type 5 Rattus norvegicus 46-51 18538475-0 2008 Regulation of PGC-1alpha and PGC-1alpha-responsive genes with forskolin-induced Schwann cell differentiation. Colforsin 62-71 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 14-24 18538475-0 2008 Regulation of PGC-1alpha and PGC-1alpha-responsive genes with forskolin-induced Schwann cell differentiation. Colforsin 62-71 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 29-39 18538475-3 2008 Forskolin-induced differentiation was associated with an upregulation of PGC-1alpha mRNA and protein, and while overexpression of PGC-1alpha upregulated genes such as manganese superoxide dismutase and estrogen-related receptor alpha, it was not sufficient for induction of differentiation. Colforsin 0-9 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 73-83 18538475-3 2008 Forskolin-induced differentiation was associated with an upregulation of PGC-1alpha mRNA and protein, and while overexpression of PGC-1alpha upregulated genes such as manganese superoxide dismutase and estrogen-related receptor alpha, it was not sufficient for induction of differentiation. Colforsin 0-9 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 130-140 18538475-3 2008 Forskolin-induced differentiation was associated with an upregulation of PGC-1alpha mRNA and protein, and while overexpression of PGC-1alpha upregulated genes such as manganese superoxide dismutase and estrogen-related receptor alpha, it was not sufficient for induction of differentiation. Colforsin 0-9 estrogen related receptor, alpha Mus musculus 202-233 18482991-4 2008 Using HEK cells stably expressing TRPV1 and the mu opioid receptor, we demonstrated that treatment with the adenylate cyclase activator forskolin significantly increased the multimeric TRPV1 species. Colforsin 136-145 transient receptor potential cation channel subfamily V member 1 Homo sapiens 185-190 18482991-8 2008 Treatment with forskolin also caused an increase in TRPV1 expression on the plasma membrane not resulting from increased TRPV1 expression, and this rapid TRPV1 translocation was inhibited by treatment with morphine. Colforsin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-57 18482991-8 2008 Treatment with forskolin also caused an increase in TRPV1 expression on the plasma membrane not resulting from increased TRPV1 expression, and this rapid TRPV1 translocation was inhibited by treatment with morphine. Colforsin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 121-126 18482991-8 2008 Treatment with forskolin also caused an increase in TRPV1 expression on the plasma membrane not resulting from increased TRPV1 expression, and this rapid TRPV1 translocation was inhibited by treatment with morphine. Colforsin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 121-126 18483184-7 2008 Direct cAMP stimulation with forskolin resulted in enhanced human GRP-R promoter activity only in HuTu-80 cells, but not in Caco-2 cells, coinciding with forskolin-induced CREB phosphorylation occurring only in HuTu-80 but not Caco-2 cells. Colforsin 29-38 cAMP responsive element binding protein 1 Homo sapiens 172-176 18434387-4 2008 Both AQP2 (S261A) and AQP2 (S261D) were located in the perinuclear cytoplasm without stimulation but, like wild-type AQP2, they both accumulated on the plasma membrane after 20-min exposure to VP or forskolin. Colforsin 199-208 aquaporin 2 Homo sapiens 5-9 18434387-4 2008 Both AQP2 (S261A) and AQP2 (S261D) were located in the perinuclear cytoplasm without stimulation but, like wild-type AQP2, they both accumulated on the plasma membrane after 20-min exposure to VP or forskolin. Colforsin 199-208 aquaporin 2 Homo sapiens 22-26 18434387-4 2008 Both AQP2 (S261A) and AQP2 (S261D) were located in the perinuclear cytoplasm without stimulation but, like wild-type AQP2, they both accumulated on the plasma membrane after 20-min exposure to VP or forskolin. Colforsin 199-208 aquaporin 2 Homo sapiens 22-26 18483184-7 2008 Direct cAMP stimulation with forskolin resulted in enhanced human GRP-R promoter activity only in HuTu-80 cells, but not in Caco-2 cells, coinciding with forskolin-induced CREB phosphorylation occurring only in HuTu-80 but not Caco-2 cells. Colforsin 154-163 cAMP responsive element binding protein 1 Homo sapiens 172-176 18483184-7 2008 Direct cAMP stimulation with forskolin resulted in enhanced human GRP-R promoter activity only in HuTu-80 cells, but not in Caco-2 cells, coinciding with forskolin-induced CREB phosphorylation occurring only in HuTu-80 but not Caco-2 cells. Colforsin 29-38 gastrin releasing peptide receptor Homo sapiens 66-71 18339759-4 2008 FRAP analysis of 5-HT(1A)R-EYFP shows that destabilization of the actin cytoskeleton induced by either CD or elevation of cAMP levels mediated by forskolin results in an increase in the mobile fraction of the receptor. Colforsin 146-155 mechanistic target of rapamycin kinase Homo sapiens 0-4 18372325-4 2008 Forskolin, at threshold concentrations for cAMP production and CREB phosphorylation, induced CRH promoter-driven luciferase activity in 4B cells (EC(50) = 0.7 microm) and CRH primary transcript in hypothalamic neurons (EC(50) = 0.6 microm). Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 63-67 18420479-12 2008 The PDE7 silencing also increased forskolin stimulated cAMP response, but had no effect on the proliferation rate. Colforsin 34-43 phosphodiesterase 7A Homo sapiens 4-8 18641693-4 2008 In rat aortic VSMCs, NPY"s mitogenic effect at all concentrations was blocked by pertussis toxin and was associated with decreased forskolin-stimulated cAMP levels. Colforsin 131-140 neuropeptide Y Rattus norvegicus 21-24 18372334-7 2008 In this report, these two pathways were examined in GnRH-1 neurons as integrators of forskolin (FSK)-induced stimulation. Colforsin 85-94 gonadotropin releasing hormone 1 Mus musculus 52-58 18407464-8 2008 LPA did not affect cAMP levels after EGF treatment, and the reagents promoting cAMP production such as forskolin and cholera toxin also attenuated the EGF-induced ERK5 phosphorylation, indicating that the inhibitory effect of LPA on ERK5 inhibition via G(i/o) is not due to inhibition of adenylyl cyclase by Galpha(i/o). Colforsin 103-112 epidermal growth factor like 1 Rattus norvegicus 151-154 18407464-8 2008 LPA did not affect cAMP levels after EGF treatment, and the reagents promoting cAMP production such as forskolin and cholera toxin also attenuated the EGF-induced ERK5 phosphorylation, indicating that the inhibitory effect of LPA on ERK5 inhibition via G(i/o) is not due to inhibition of adenylyl cyclase by Galpha(i/o). Colforsin 103-112 mitogen-activated protein kinase 7 Rattus norvegicus 163-167 18407464-8 2008 LPA did not affect cAMP levels after EGF treatment, and the reagents promoting cAMP production such as forskolin and cholera toxin also attenuated the EGF-induced ERK5 phosphorylation, indicating that the inhibitory effect of LPA on ERK5 inhibition via G(i/o) is not due to inhibition of adenylyl cyclase by Galpha(i/o). Colforsin 103-112 mitogen-activated protein kinase 7 Rattus norvegicus 233-237 18455831-9 2008 Forskolin, a protein kinase A stimulator, reduced the adiponectin production stimulated by glimepiride but not by pioglitazone. Colforsin 0-9 adiponectin, C1Q and collagen domain containing Mus musculus 54-65 18372334-7 2008 In this report, these two pathways were examined in GnRH-1 neurons as integrators of forskolin (FSK)-induced stimulation. Colforsin 96-99 gonadotropin releasing hormone 1 Mus musculus 52-58 18372325-4 2008 Forskolin, at threshold concentrations for cAMP production and CREB phosphorylation, induced CRH promoter-driven luciferase activity in 4B cells (EC(50) = 0.7 microm) and CRH primary transcript in hypothalamic neurons (EC(50) = 0.6 microm). Colforsin 0-9 corticotropin releasing hormone Homo sapiens 93-96 18372334-9 2008 ZD7288, a HCN channel blocker, significantly reduced the efficiency of FSK to stimulate GnRH-1 neurons, whereas blockade of PKA with Rp-adenosine-3",5"-cyclic monophosphorothioate triethylammonium did not attenuate the FSK-induced stimulation. Colforsin 71-74 gonadotropin releasing hormone 1 Mus musculus 88-94 18372325-4 2008 Forskolin, at threshold concentrations for cAMP production and CREB phosphorylation, induced CRH promoter-driven luciferase activity in 4B cells (EC(50) = 0.7 microm) and CRH primary transcript in hypothalamic neurons (EC(50) = 0.6 microm). Colforsin 0-9 corticotropin releasing hormone Homo sapiens 171-174 18372334-11 2008 Under these conditions, Rp-adenosine-3",5"-cyclic monophosphorothioate triethylammonium, but not ZD7288, altered the FSK-induced response of GnRH-1 neurons. Colforsin 117-120 gonadotropin releasing hormone 1 Mus musculus 141-147 18372334-12 2008 These studies indicate that PKA-dependent phosphorylation is involved in the FSK-induced stimulation of GnRH-1 neurons rather than HCN channels, and HCN channels integrate the FSK-induced stimulation on GABAergic neurons. Colforsin 77-80 gonadotropin releasing hormone 1 Mus musculus 104-110 18372325-5 2008 PMA alone failed to activate CRH transcription despite being as effective as forskolin in phosphorylating CREB (Ser133 and Ser121). Colforsin 77-86 cAMP responsive element binding protein 1 Homo sapiens 106-110 18372325-7 2008 Similarly, the calcium/calmodulin-dependent kinase inhibitor, KN-93, enhanced PMA plus forskolin-stimulated CREB phosphorylation and inhibited CRH transcription. Colforsin 87-96 cAMP responsive element binding protein 1 Homo sapiens 108-112 18372325-7 2008 Similarly, the calcium/calmodulin-dependent kinase inhibitor, KN-93, enhanced PMA plus forskolin-stimulated CREB phosphorylation and inhibited CRH transcription. Colforsin 87-96 corticotropin releasing hormone Homo sapiens 143-146 18287572-5 2008 In vitro studies with primary mouse granulosa cells document that Adam8 is induced in response to forskolin (Fo) and phorbol ester (PMA) or Fo and Amphiregulin treatment. Colforsin 98-107 a disintegrin and metallopeptidase domain 8 Mus musculus 66-71 18571589-11 2008 The cAMP stimulators forskolin and IBMX abolished TSP-1-induced chemotaxis and ERK and p38 activation. Colforsin 21-30 thrombospondin 1 Homo sapiens 50-55 18571589-11 2008 The cAMP stimulators forskolin and IBMX abolished TSP-1-induced chemotaxis and ERK and p38 activation. Colforsin 21-30 mitogen-activated protein kinase 1 Homo sapiens 79-82 18571589-11 2008 The cAMP stimulators forskolin and IBMX abolished TSP-1-induced chemotaxis and ERK and p38 activation. Colforsin 21-30 mitogen-activated protein kinase 1 Homo sapiens 87-90 18973017-4 2008 RESULTS: Forskolin (10(-7), 10(-6), 10(-5) M) could inhibit both the expression of CD69 on CD3+ T lymphocytes and T lymphocyte proliferation index stimulated by Con A in a dose-dependent manner. Colforsin 9-18 CD69 antigen Mus musculus 83-87 18451066-9 2008 The TSH effect on the GRK2 expression was mimicked by forskolin. Colforsin 54-63 G protein-coupled receptor kinase 2 Homo sapiens 22-26 18389276-3 2008 We found that the cAMP-elevating agent forskolin increased annexin-2 abundance in the plasma membrane enriched fraction with a parallel decrease in the soluble fraction. Colforsin 39-48 annexin A2 Homo sapiens 59-68 18389276-4 2008 Interestingly, forskolin stimulation resulted in annexin-2 enrichment in lipid rafts, suggesting that hormonal stimulation might be responsible for a new configuration of membrane interacting proteins involved in the fusion of AQP2 vesicles to the apical plasma membrane. Colforsin 15-24 annexin A2 Homo sapiens 49-58 18389276-4 2008 Interestingly, forskolin stimulation resulted in annexin-2 enrichment in lipid rafts, suggesting that hormonal stimulation might be responsible for a new configuration of membrane interacting proteins involved in the fusion of AQP2 vesicles to the apical plasma membrane. Colforsin 15-24 aquaporin 2 Homo sapiens 227-231 18538351-4 2008 Both SP-cAMP, a membrane-permeable and phosphodiesterase resistant cAMP, and forskolin, an adenylate cyclase stimulator significantly increased AQP1 mRNA expression in all cell lines after 2 h in a dose-dependent manner (P<0.05) with a parallel increase in protein expression. Colforsin 77-86 aquaporin 1 (Colton blood group) Homo sapiens 144-148 18538351-5 2008 In the time course study, 5 microM of either SP-cAMP or forskolin significantly stimulated AQP1 mRNA expression after 2 h in HTR-8/SVneo cells and after 10 h in JAR and JEG-3 cells. Colforsin 56-65 aquaporin 1 (Colton blood group) Homo sapiens 91-95 18390901-3 2008 To examine these questions, 3T3-L1 adipocytes were treated with cAMP-inducing agents (isoproterenol, forskolin, and isobutylmethylxanthine), which stimulate lipolysis and activate AMPK. Colforsin 101-110 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 180-184 18427166-1 2008 Immunomodulators such as lipopolysaccharides (LPS) and forskolin change the nature of dendritic cells (DCs) to induce Th1 and Th2 cells, respectively, thereby designated Th1 or Th2 adjuvants. Colforsin 55-64 negative elongation factor complex member C/D Homo sapiens 118-121 18427166-1 2008 Immunomodulators such as lipopolysaccharides (LPS) and forskolin change the nature of dendritic cells (DCs) to induce Th1 and Th2 cells, respectively, thereby designated Th1 or Th2 adjuvants. Colforsin 55-64 negative elongation factor complex member C/D Homo sapiens 170-173 18463910-5 2008 Furthermore, the adenylyl cyclase activator, forskolin (50 nM), significantly enhanced the excitatory response to both FLP17A and 5-HT. Colforsin 45-54 GAKFIRF-amide Caenorhabditis elegans 119-131 18213449-5 2008 Remarkably, drugs such as forskolin, 1,9-dideoxy-forskolin and FTY720 which lead to PP2A activation effectively antagonize leukemogenesis in both in vitro and in vivo models of these cancers. Colforsin 26-35 protein phosphatase 2 phosphatase activator Homo sapiens 84-88 18437352-7 2008 Strong stimulation with a secretagogue mixture induced parallel release of insulin and chromogranin B, whereas with 3-isobutyl-1-methylxantine and forskolin +/- high glucose release of chromogranin B predominated. Colforsin 147-156 chromogranin B Homo sapiens 185-199 18308847-7 2008 The effect of human chorionic gonadotropin on Rgc32 expression was mimicked by forskolin, but not phorbol 12-myristate 13-acetate, and was mediated by the activation of progesterone receptors and the epidermal growth factor-signaling pathway. Colforsin 79-88 regulator of cell cycle Homo sapiens 46-51 18392843-3 2008 In human dermal microvascular endothelial cells (HDMEC), treatment with forskolin/rolipram (F/R) to increase cAMP by as well as the Epac/Rap 1-stimulating cAMP analogue 8-pCPT-2"-O-methyl-cAMP (O-Me-cAMP) stabilized endothelial barrier properties as revealed by raised transendothelial electrical resistance (TER). Colforsin 72-81 cathelicidin antimicrobial peptide Homo sapiens 109-113 18392843-3 2008 In human dermal microvascular endothelial cells (HDMEC), treatment with forskolin/rolipram (F/R) to increase cAMP by as well as the Epac/Rap 1-stimulating cAMP analogue 8-pCPT-2"-O-methyl-cAMP (O-Me-cAMP) stabilized endothelial barrier properties as revealed by raised transendothelial electrical resistance (TER). Colforsin 72-81 RAP1A, member of RAS oncogene family Homo sapiens 137-142 18309088-3 2008 In this study, we report that in human airway epithelial CF15 cells treated with the CFTR corrector miglustat (n-butyldeoxynojyrimicin), whole-cell patch-clamp experiments showed reduced amiloride-sensitive ENaC current in parallel with a rescue of defective CFTR Cl- channel activity activated by forskolin and genistein. Colforsin 298-307 CF transmembrane conductance regulator Homo sapiens 85-89 18403126-7 2008 Remarkably, low doses of a selective D1 receptors agonist or forskolin, an activator of adenylate cyclase, accelerated the formation of mutant htt nuclear aggregates, whereas the number of cytoplasmic aggregates was decreased. Colforsin 61-70 huntingtin Homo sapiens 143-146 18362103-2 2008 Forskolin and dibutyryl cAMP mimic PACAP"s neuritogenic and cell morphological effects, suggesting that they are driven by cAMP. Colforsin 0-9 adenylate cyclase activating polypeptide 1 Rattus norvegicus 35-40 18569866-4 2008 Since cAMP is a negative regulator in platelets, we measured the effect of the platelet antagonists PGE(1) and forskolin (both of which raise intracellular cAMP levels) on PLD activity in resting and thrombin-activated platelets. Colforsin 111-120 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 172-175 18569866-5 2008 We found that both PGE(1) and forskolin inhibited thrombin-induced PLD activation by 40-50%, but interestingly PGE(1) caused a modest elevation of PLD activity in resting platelets. Colforsin 30-39 coagulation factor II, thrombin Homo sapiens 50-58 18569866-5 2008 We found that both PGE(1) and forskolin inhibited thrombin-induced PLD activation by 40-50%, but interestingly PGE(1) caused a modest elevation of PLD activity in resting platelets. Colforsin 30-39 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 18569866-7 2008 We found that PGE(1), forskolin and the PKA activator inhibited PLD1 translocation in thrombin-stimulated platelets, and that the PKG-activator had no effect. Colforsin 22-31 phospholipase D1 Homo sapiens 64-68 18569866-7 2008 We found that PGE(1), forskolin and the PKA activator inhibited PLD1 translocation in thrombin-stimulated platelets, and that the PKG-activator had no effect. Colforsin 22-31 coagulation factor II, thrombin Homo sapiens 86-94 19124364-3 2008 Forskolin opened BKCa channels in FHR PASMC, which was blocked by PKC activation, and reversed by the phosphodiesterase (PDE) inhibitors IBMX, milrinone, and zaprinast. Colforsin 0-9 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 17-21 18456249-9 2008 While the classical melanoma differentiation agent forskolin activates cAMP-PKA-Raf-MEK-ERK pathway in B16F10 cells, here we suggest that a cAMP-independent, PKC-ERK axis is involved in Guo-induced B16F10 differentiation. Colforsin 51-60 zinc fingers and homeoboxes 2 Mus musculus 80-83 18456249-9 2008 While the classical melanoma differentiation agent forskolin activates cAMP-PKA-Raf-MEK-ERK pathway in B16F10 cells, here we suggest that a cAMP-independent, PKC-ERK axis is involved in Guo-induced B16F10 differentiation. Colforsin 51-60 midkine Mus musculus 84-87 18456249-9 2008 While the classical melanoma differentiation agent forskolin activates cAMP-PKA-Raf-MEK-ERK pathway in B16F10 cells, here we suggest that a cAMP-independent, PKC-ERK axis is involved in Guo-induced B16F10 differentiation. Colforsin 51-60 mitogen-activated protein kinase 1 Mus musculus 88-91 18456249-9 2008 While the classical melanoma differentiation agent forskolin activates cAMP-PKA-Raf-MEK-ERK pathway in B16F10 cells, here we suggest that a cAMP-independent, PKC-ERK axis is involved in Guo-induced B16F10 differentiation. Colforsin 51-60 mitogen-activated protein kinase 1 Mus musculus 162-165 18004794-7 2008 The results suggested that (1) ERK pathway of rat ZFR cells might be PKA dependent, (2) ERK activity was required for SF-1 phosphorylation to upregulate steroidogenesis in rat ZFR cells, and (3) DHEA did not affect ERK phosphorylation, however, it attenuated forskolin-stimulated SF-1 phosphorylation to affect StAR protein expression. Colforsin 259-268 Eph receptor B1 Rattus norvegicus 31-34 18004794-7 2008 The results suggested that (1) ERK pathway of rat ZFR cells might be PKA dependent, (2) ERK activity was required for SF-1 phosphorylation to upregulate steroidogenesis in rat ZFR cells, and (3) DHEA did not affect ERK phosphorylation, however, it attenuated forskolin-stimulated SF-1 phosphorylation to affect StAR protein expression. Colforsin 259-268 Eph receptor B1 Rattus norvegicus 88-91 18004794-7 2008 The results suggested that (1) ERK pathway of rat ZFR cells might be PKA dependent, (2) ERK activity was required for SF-1 phosphorylation to upregulate steroidogenesis in rat ZFR cells, and (3) DHEA did not affect ERK phosphorylation, however, it attenuated forskolin-stimulated SF-1 phosphorylation to affect StAR protein expression. Colforsin 259-268 splicing factor 1 Rattus norvegicus 118-122 18004794-7 2008 The results suggested that (1) ERK pathway of rat ZFR cells might be PKA dependent, (2) ERK activity was required for SF-1 phosphorylation to upregulate steroidogenesis in rat ZFR cells, and (3) DHEA did not affect ERK phosphorylation, however, it attenuated forskolin-stimulated SF-1 phosphorylation to affect StAR protein expression. Colforsin 259-268 Eph receptor B1 Rattus norvegicus 88-91 18355946-5 2008 In contrast, UII was found to inhibit forskolin-induced cAMP formation. Colforsin 38-47 urotensin 2 Rattus norvegicus 13-16 18463244-0 2008 Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons. Colforsin 76-85 A kinase (PRKA) anchor protein 5 Mus musculus 31-38 18463244-0 2008 Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons. Colforsin 76-85 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 56-61 18463244-5 2008 In functional studies, PKA stimulation with forskolin markedly reduced desensitization of TRPV1. Colforsin 44-53 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 90-95 18463244-8 2008 Both the forskolin and PGE(2) effects were strongly impaired in DRG neurons from knock-in mice that express a mutant AKAP150 lacking the PKA-binding domain (Delta36 mice). Colforsin 9-18 A kinase (PRKA) anchor protein 5 Mus musculus 117-124 18319251-3 2008 Ae2(a,b)(-/-) fibroblasts show increased pH(i) (by 0.22 +/- 0.03 unit) compared with wild type cells at extracellular pH (pH(o)) 7.4 and 37 degrees C. This shift in resting pH(i) is associated with an up-regulation of bicarbonate-activated soluble adenylyl cyclase expression, increased cAMP production, Creb phosphorylation, inducible cAMP early repressor 1 mRNA expression, and impaired activation of c-Fos transcription by forskolin. Colforsin 426-435 solute carrier family 4 (anion exchanger), member 2 Mus musculus 0-3 18202121-9 2008 In BHP 2-7 cells, forskolin stimulated the thyroid-specific transcription factor Pax 8, but CREM activator mRNA did not increase, and this produced a small increase in NUE activity. Colforsin 18-27 paired box 8 Homo sapiens 81-86 17990294-4 2008 Wnt3a and forskolin synergistically increased the TCF-dependent transactivation. Colforsin 10-19 hepatocyte nuclear factor 4 alpha Homo sapiens 50-53 17990294-6 2008 In addition to the effects on TCF-dependent reporter activity, treatment with PTH or forskolin resulted in the increased expression of endogenous targets of Wnts, Wnt-induced secreted protein 2 (WISP2) and naked cuticle 2 (NKD2). Colforsin 85-94 hepatocyte nuclear factor 4 alpha Homo sapiens 30-33 17990294-6 2008 In addition to the effects on TCF-dependent reporter activity, treatment with PTH or forskolin resulted in the increased expression of endogenous targets of Wnts, Wnt-induced secreted protein 2 (WISP2) and naked cuticle 2 (NKD2). Colforsin 85-94 cellular communication network factor 5 Homo sapiens 163-193 17990294-6 2008 In addition to the effects on TCF-dependent reporter activity, treatment with PTH or forskolin resulted in the increased expression of endogenous targets of Wnts, Wnt-induced secreted protein 2 (WISP2) and naked cuticle 2 (NKD2). Colforsin 85-94 cellular communication network factor 5 Homo sapiens 195-200 17990294-6 2008 In addition to the effects on TCF-dependent reporter activity, treatment with PTH or forskolin resulted in the increased expression of endogenous targets of Wnts, Wnt-induced secreted protein 2 (WISP2) and naked cuticle 2 (NKD2). Colforsin 85-94 NKD inhibitor of WNT signaling pathway 2 Homo sapiens 206-221 17990294-6 2008 In addition to the effects on TCF-dependent reporter activity, treatment with PTH or forskolin resulted in the increased expression of endogenous targets of Wnts, Wnt-induced secreted protein 2 (WISP2) and naked cuticle 2 (NKD2). Colforsin 85-94 NKD inhibitor of WNT signaling pathway 2 Homo sapiens 223-227 17990294-8 2008 Western blotting demonstrated that GSK-3beta was rapidly phosphorylated at Ser(9) on treatment with PTH or forskolin, leading to its inactivation. Colforsin 107-116 glycogen synthase kinase 3 beta Homo sapiens 35-44 17990294-9 2008 Moreover, overexpression of a constitutively active mutant of GSK-3beta abolished the TCF-dependent transactivation induced by forskolin. Colforsin 127-136 glycogen synthase kinase 3 beta Homo sapiens 62-71 17990294-9 2008 Moreover, overexpression of a constitutively active mutant of GSK-3beta abolished the TCF-dependent transactivation induced by forskolin. Colforsin 127-136 hepatocyte nuclear factor 4 alpha Homo sapiens 86-89 17990294-11 2008 Interestingly, treatment with Wnt3a markedly reduced the forskolin-induced expression of receptor activator of NF-kappaB ligand (RANKL), a target gene of PTH/cAMP/PKA. Colforsin 57-66 Wnt family member 3A Homo sapiens 30-35 17990294-11 2008 Interestingly, treatment with Wnt3a markedly reduced the forskolin-induced expression of receptor activator of NF-kappaB ligand (RANKL), a target gene of PTH/cAMP/PKA. Colforsin 57-66 TNF superfamily member 11 Homo sapiens 89-127 17990294-11 2008 Interestingly, treatment with Wnt3a markedly reduced the forskolin-induced expression of receptor activator of NF-kappaB ligand (RANKL), a target gene of PTH/cAMP/PKA. Colforsin 57-66 TNF superfamily member 11 Homo sapiens 129-134 17990294-11 2008 Interestingly, treatment with Wnt3a markedly reduced the forskolin-induced expression of receptor activator of NF-kappaB ligand (RANKL), a target gene of PTH/cAMP/PKA. Colforsin 57-66 parathyroid hormone Homo sapiens 154-157 17990294-11 2008 Interestingly, treatment with Wnt3a markedly reduced the forskolin-induced expression of receptor activator of NF-kappaB ligand (RANKL), a target gene of PTH/cAMP/PKA. Colforsin 57-66 cathelicidin antimicrobial peptide Homo sapiens 158-162 18384819-5 2008 In an adenosine depleted background (with ADA), activation of adenosine A2A receptors (with 10nM CGS21680) restored the facilitatory effect of BDNF on LTP; this was fully prevented by the protein kinase A inhibitor, H-89 (1 microM) and mimicked by the adenylate cyclase activator, forskolin (10 microM). Colforsin 281-290 brain derived neurotrophic factor Homo sapiens 143-147 18267956-6 2008 VEGF-stimulated cell migration was inhibited by activation of adenylyl cyclase with forskolin, and adiponectin treatment increased cellular cyclic adenosine monophosphate (cAMP) levels and protein kinase A (PKA) enzymatic activity. Colforsin 84-93 vascular endothelial growth factor A Homo sapiens 0-4 18252896-7 2008 This effect was mimicked with the use of cAMP-raising agents isobutylmethylxanthine and forskolin and required activation of the protein kinase A. Inhibition of the JNK pathway by ex-4 or IBMX and forskolin was concomitant with a rise in the levels of islet-brain 1 (IB1), a potent blocker of the stress-induced JNK pathway. Colforsin 88-97 mitogen-activated protein kinase 8 Rattus norvegicus 165-168 18252896-7 2008 This effect was mimicked with the use of cAMP-raising agents isobutylmethylxanthine and forskolin and required activation of the protein kinase A. Inhibition of the JNK pathway by ex-4 or IBMX and forskolin was concomitant with a rise in the levels of islet-brain 1 (IB1), a potent blocker of the stress-induced JNK pathway. Colforsin 88-97 mitogen-activated protein kinase 8 interacting protein 1 Rattus norvegicus 252-265 18252896-7 2008 This effect was mimicked with the use of cAMP-raising agents isobutylmethylxanthine and forskolin and required activation of the protein kinase A. Inhibition of the JNK pathway by ex-4 or IBMX and forskolin was concomitant with a rise in the levels of islet-brain 1 (IB1), a potent blocker of the stress-induced JNK pathway. Colforsin 88-97 mitogen-activated protein kinase 8 interacting protein 1 Rattus norvegicus 267-270 18252896-7 2008 This effect was mimicked with the use of cAMP-raising agents isobutylmethylxanthine and forskolin and required activation of the protein kinase A. Inhibition of the JNK pathway by ex-4 or IBMX and forskolin was concomitant with a rise in the levels of islet-brain 1 (IB1), a potent blocker of the stress-induced JNK pathway. Colforsin 88-97 mitogen-activated protein kinase 8 Rattus norvegicus 312-315 18252896-7 2008 This effect was mimicked with the use of cAMP-raising agents isobutylmethylxanthine and forskolin and required activation of the protein kinase A. Inhibition of the JNK pathway by ex-4 or IBMX and forskolin was concomitant with a rise in the levels of islet-brain 1 (IB1), a potent blocker of the stress-induced JNK pathway. Colforsin 197-206 mitogen-activated protein kinase 8 Rattus norvegicus 165-168 18252896-7 2008 This effect was mimicked with the use of cAMP-raising agents isobutylmethylxanthine and forskolin and required activation of the protein kinase A. Inhibition of the JNK pathway by ex-4 or IBMX and forskolin was concomitant with a rise in the levels of islet-brain 1 (IB1), a potent blocker of the stress-induced JNK pathway. Colforsin 197-206 mitogen-activated protein kinase 8 interacting protein 1 Rattus norvegicus 252-265 18252896-7 2008 This effect was mimicked with the use of cAMP-raising agents isobutylmethylxanthine and forskolin and required activation of the protein kinase A. Inhibition of the JNK pathway by ex-4 or IBMX and forskolin was concomitant with a rise in the levels of islet-brain 1 (IB1), a potent blocker of the stress-induced JNK pathway. Colforsin 197-206 mitogen-activated protein kinase 8 interacting protein 1 Rattus norvegicus 267-270 18252896-7 2008 This effect was mimicked with the use of cAMP-raising agents isobutylmethylxanthine and forskolin and required activation of the protein kinase A. Inhibition of the JNK pathway by ex-4 or IBMX and forskolin was concomitant with a rise in the levels of islet-brain 1 (IB1), a potent blocker of the stress-induced JNK pathway. Colforsin 197-206 mitogen-activated protein kinase 8 Rattus norvegicus 312-315 18252896-8 2008 In fact, ex-4 as well as IBMX and forskolin induced expression of IB1 at the promoter level through cAMP response element binding transcription factor 1. Colforsin 34-43 mitogen-activated protein kinase 8 interacting protein 1 Rattus norvegicus 66-69 17990294-3 2008 Treatment with PTH or forskolin, an activator of adenylate cyclase, facilitated T-cell factor (TCF)-dependent transactivation in a dose-dependent manner, which was abolished by pre-treatment with a PKA inhibitor, H89. Colforsin 22-31 hepatocyte nuclear factor 4 alpha Homo sapiens 80-93 17990294-3 2008 Treatment with PTH or forskolin, an activator of adenylate cyclase, facilitated T-cell factor (TCF)-dependent transactivation in a dose-dependent manner, which was abolished by pre-treatment with a PKA inhibitor, H89. Colforsin 22-31 hepatocyte nuclear factor 4 alpha Homo sapiens 95-98 18285510-5 2008 Maximal inhibition of forskolin-stimulated adenylyl cyclase by the low-efficacy partial agonists buprenorphine and nalbuphine was increased in cells expressing RGS-insensitive Galpha(o)(CIGS), Galpha(i2)(CIGS), or Galpha(i3)(CIGS) compared with their Galpha(CI) counterparts, but the RGS-insensitive mutation had little or no effect on the maximal inhibition by the higher efficacy agonists DAMGO and morphine. Colforsin 22-31 paired like homeodomain 2 Homo sapiens 160-163 18285510-5 2008 Maximal inhibition of forskolin-stimulated adenylyl cyclase by the low-efficacy partial agonists buprenorphine and nalbuphine was increased in cells expressing RGS-insensitive Galpha(o)(CIGS), Galpha(i2)(CIGS), or Galpha(i3)(CIGS) compared with their Galpha(CI) counterparts, but the RGS-insensitive mutation had little or no effect on the maximal inhibition by the higher efficacy agonists DAMGO and morphine. Colforsin 22-31 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 193-202 18285510-5 2008 Maximal inhibition of forskolin-stimulated adenylyl cyclase by the low-efficacy partial agonists buprenorphine and nalbuphine was increased in cells expressing RGS-insensitive Galpha(o)(CIGS), Galpha(i2)(CIGS), or Galpha(i3)(CIGS) compared with their Galpha(CI) counterparts, but the RGS-insensitive mutation had little or no effect on the maximal inhibition by the higher efficacy agonists DAMGO and morphine. Colforsin 22-31 brain protein I3 Homo sapiens 214-223 18285510-5 2008 Maximal inhibition of forskolin-stimulated adenylyl cyclase by the low-efficacy partial agonists buprenorphine and nalbuphine was increased in cells expressing RGS-insensitive Galpha(o)(CIGS), Galpha(i2)(CIGS), or Galpha(i3)(CIGS) compared with their Galpha(CI) counterparts, but the RGS-insensitive mutation had little or no effect on the maximal inhibition by the higher efficacy agonists DAMGO and morphine. Colforsin 22-31 paired like homeodomain 2 Homo sapiens 284-287 18285510-6 2008 The potency of all the agonists to inhibit forskolin-stimulated adenylyl cyclase was increased in cells expressing RGS-insensitive Galpha(o)(CIGS), Galpha(i2)(CIGS), or Galpha(i3)(CIGS), regardless of efficacy. Colforsin 43-52 paired like homeodomain 2 Homo sapiens 115-118 18285510-6 2008 The potency of all the agonists to inhibit forskolin-stimulated adenylyl cyclase was increased in cells expressing RGS-insensitive Galpha(o)(CIGS), Galpha(i2)(CIGS), or Galpha(i3)(CIGS), regardless of efficacy. Colforsin 43-52 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 148-157 18285510-6 2008 The potency of all the agonists to inhibit forskolin-stimulated adenylyl cyclase was increased in cells expressing RGS-insensitive Galpha(o)(CIGS), Galpha(i2)(CIGS), or Galpha(i3)(CIGS), regardless of efficacy. Colforsin 43-52 brain protein I3 Homo sapiens 169-178 18215138-4 2008 Despite their chemical, structural and functional variety and different target motifs on AC, G(betagamma) and calmodulin share a two-site-interaction mechanism with G(alphas) and forskolin to modulate AC activity. Colforsin 179-188 calmodulin 1 Homo sapiens 110-120 18328477-4 2008 Moreover, we have shown earlier that sustained opioid agonist treatment leads to a Raf-1-dependent sensitization of adenylyl cyclase(s) (AC superactivation), augmenting forskolin-stimulated cAMP formation upon opioid withdrawal (cAMP overshoot). Colforsin 169-178 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 83-88 18367155-2 2008 Addition of forskolin to the cocultures induced demyelination and lower levels of myelin protein P0 expression were seen in immunoblots after eight days of treatment. Colforsin 12-21 myelin protein zero Rattus norvegicus 82-99 18287089-0 2008 Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. Colforsin 213-222 transforming growth factor beta 1 Homo sapiens 0-32 18287089-0 2008 Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. Colforsin 213-222 transforming growth factor beta 1 Homo sapiens 34-42 18287089-0 2008 Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. Colforsin 213-222 cellular communication network factor 2 Homo sapiens 55-86 18287089-0 2008 Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. Colforsin 213-222 cellular communication network factor 2 Homo sapiens 88-92 18287089-0 2008 Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. Colforsin 213-222 cellular communication network factor 2 Homo sapiens 93-97 18287089-7 2008 We previously demonstrated that JNK1 phosphorylation by TGFbeta1 is also critical for TGFbeta1-induced CCN2/CTGF expression, and forskolin partially reduces levels of phosphorylated JNK1. Colforsin 129-138 transforming growth factor beta 1 Homo sapiens 86-94 18287089-7 2008 We previously demonstrated that JNK1 phosphorylation by TGFbeta1 is also critical for TGFbeta1-induced CCN2/CTGF expression, and forskolin partially reduces levels of phosphorylated JNK1. Colforsin 129-138 mitogen-activated protein kinase 8 Homo sapiens 182-186 18287089-9 2008 The combination of lovastatin and forskolin results in a greater inhibitory effect than each agent alone and reduces CCN2/CTGF mRNA and protein expression by greater than 90%. Colforsin 34-43 cellular communication network factor 2 Homo sapiens 117-121 18287089-9 2008 The combination of lovastatin and forskolin results in a greater inhibitory effect than each agent alone and reduces CCN2/CTGF mRNA and protein expression by greater than 90%. Colforsin 34-43 cellular communication network factor 2 Homo sapiens 122-126 18418428-5 2008 The basal adenylyl cyclase activity as well as isoproterenol and forskolin-mediated stimulation of adenylyl cyclase was significantly attenuated in VSMC from 12-week-old SHR compared with those from WKY rats, whereas Ang II-mediated inhibition of adenylyl cyclase was significantly enhanced by about 70%, resulting in decreased levels of cAMP in SHR. Colforsin 65-74 angiotensinogen Rattus norvegicus 217-223 18281604-6 2008 Potentiation of VASP Ser(157) phosphorylation by either phosphatase 2B inhibition with cyclosporin or protein kinase A activation with forskolin prolonged, rather than inhibited, the increased permeability caused by H(2)O(2). Colforsin 135-144 vasodilator stimulated phosphoprotein Homo sapiens 16-20 18372242-8 2008 BMP-4 specifically enhanced GH secretion and cAMP production induced by forskolin in GH3 cells. Colforsin 72-81 bone morphogenetic protein 4 Rattus norvegicus 0-5 18096663-4 2008 Here we show that the dopamine agonist-induced inhibition of spontaneous Ca(2+) influx and release of prestored PRL was preserved when cAMP levels were elevated by forskolin treatment. Colforsin 164-173 prolactin Homo sapiens 112-115 18325495-2 2008 Increasing intracellular [cAMP] with forskolin stimulates an NPPB and glibenclamide-inhibitable apical Cl(-) and HCO(3)(-) permeability [Sun, X.C., Bonanno, J.A., 2002. Colforsin 37-46 natriuretic peptide B Bos taurus 61-65 18325495-17 2008 We conclude that forskolin induced increases in apical HCO(3)(-) permeability in bovine corneal endothelium requires CFTR. Colforsin 17-26 CF transmembrane conductance regulator Bos taurus 117-121 18418428-8 2008 Treatment of VSMC from SHR with 8Br-cAMP, as well as with cAMP-elevating agents such as isoproterenol and forskolin, restored to control WKY levels the enhanced activity of NADPH oxidase and the enhanced levels of O(2)(-), p47(phox), and Nox4. Colforsin 106-115 NSFL1 cofactor Rattus norvegicus 223-226 18418428-8 2008 Treatment of VSMC from SHR with 8Br-cAMP, as well as with cAMP-elevating agents such as isoproterenol and forskolin, restored to control WKY levels the enhanced activity of NADPH oxidase and the enhanced levels of O(2)(-), p47(phox), and Nox4. Colforsin 106-115 cytochrome b-245 alpha chain Rattus norvegicus 227-231 18418428-8 2008 Treatment of VSMC from SHR with 8Br-cAMP, as well as with cAMP-elevating agents such as isoproterenol and forskolin, restored to control WKY levels the enhanced activity of NADPH oxidase and the enhanced levels of O(2)(-), p47(phox), and Nox4. Colforsin 106-115 NADPH oxidase 4 Rattus norvegicus 238-242 18372242-11 2008 In the presence of BMP-4, a high concentration of OCT also attenuated the BRC effects suppressing forskolin-induced GH and cAMP production. Colforsin 98-107 bone morphogenetic protein 4 Rattus norvegicus 19-24 18279850-2 2008 JWH133 was demonstrated to be a selective cannabinoid CB2 receptor agonist in mice, reducing forskolin-stimulated cAMP production in CHO cells expressing mouse cannabinoid CB2 and cannabinoid CB1 receptors with EC50 values of 63 nM and 2500 nM, respectively. Colforsin 93-102 cannabinoid receptor 2 (macrophage) Mus musculus 54-57 18187604-6 2008 By semiquantitative RT-PCR, increases in amphiregulin and epiregulin mRNAs were detected 30 min after recombinant LH stimulation of follicles and were maximal after 2 h. LH-induced EGFR phosphorylation also increased after 30 min and reached a maximum at 2 h. EGFR activation precedes oocyte maturation and is cAMP dependent, because forskolin similarly activated EGFR. Colforsin 334-343 amphiregulin Homo sapiens 41-53 18187604-6 2008 By semiquantitative RT-PCR, increases in amphiregulin and epiregulin mRNAs were detected 30 min after recombinant LH stimulation of follicles and were maximal after 2 h. LH-induced EGFR phosphorylation also increased after 30 min and reached a maximum at 2 h. EGFR activation precedes oocyte maturation and is cAMP dependent, because forskolin similarly activated EGFR. Colforsin 334-343 epidermal growth factor receptor Homo sapiens 181-185 18215420-6 2008 We also found that forskolin (a direct adenylate cyclase activator) can mimic the action of hypoxia on the production of MMP-9 by DCs, whereas the adenylate cyclase inhibitor SQ22536 and the PKA inhibitor H89 can abrogate the inhibition of MMP-9 produce by mDCs under hypoxia. Colforsin 19-28 matrix metallopeptidase 9 Homo sapiens 121-126 18215420-6 2008 We also found that forskolin (a direct adenylate cyclase activator) can mimic the action of hypoxia on the production of MMP-9 by DCs, whereas the adenylate cyclase inhibitor SQ22536 and the PKA inhibitor H89 can abrogate the inhibition of MMP-9 produce by mDCs under hypoxia. Colforsin 19-28 matrix metallopeptidase 9 Homo sapiens 240-245 18279850-2 2008 JWH133 was demonstrated to be a selective cannabinoid CB2 receptor agonist in mice, reducing forskolin-stimulated cAMP production in CHO cells expressing mouse cannabinoid CB2 and cannabinoid CB1 receptors with EC50 values of 63 nM and 2500 nM, respectively. Colforsin 93-102 cannabinoid receptor 2 (macrophage) Mus musculus 172-175 18279850-2 2008 JWH133 was demonstrated to be a selective cannabinoid CB2 receptor agonist in mice, reducing forskolin-stimulated cAMP production in CHO cells expressing mouse cannabinoid CB2 and cannabinoid CB1 receptors with EC50 values of 63 nM and 2500 nM, respectively. Colforsin 93-102 cannabinoid receptor 1 (brain) Mus musculus 192-195 17959910-3 2008 In Chinese hamster ovary cells expressing the human A3-AR, the fluorescent A3-AR agonist was able to inhibit forskolin-stimulated [3H]cAMP production (pEC50=8.57), and this was antagonized by the A3-selective antagonist MRS1220 (pK(B)=9.32). Colforsin 109-118 adenosine A3 receptor Homo sapiens 52-57 18162607-6 2008 Comparable inhibition of PAR-1 expression was observed with the selective IP-receptor agonist cicaprost, the adenylyl cyclase activator forskolin, the phosphodiesterase inhibitor isobutylmethylxanthine and the PKA activator dibutyryl-cAMP. Colforsin 136-145 coagulation factor II thrombin receptor Homo sapiens 25-30 18280640-3 2008 In the latter cell type, secretion of IL-6 is stimulated notably by interleukin-1 (IL-1), thyroid-stimulating hormone (TSH) or forskolin (Fk), a cAMP elevating agent. Colforsin 127-136 interleukin 6 Rattus norvegicus 38-42 17988215-7 2008 Activation of PKA with forskolin promoted MCOLN1 phosphorylation, both in vitro and in vivo. Colforsin 23-32 mucolipin TRP cation channel 1 Homo sapiens 42-48 17988215-10 2008 Forskolin treatment decreased MCOLN1 channel activity, whereas treatment with H89 increased MCOLN1 channel activity. Colforsin 0-9 mucolipin TRP cation channel 1 Homo sapiens 30-36 17959910-3 2008 In Chinese hamster ovary cells expressing the human A3-AR, the fluorescent A3-AR agonist was able to inhibit forskolin-stimulated [3H]cAMP production (pEC50=8.57), and this was antagonized by the A3-selective antagonist MRS1220 (pK(B)=9.32). Colforsin 109-118 adenosine A3 receptor Homo sapiens 75-80 18253488-3 2008 METHODS AND FINDINGS: We report that activation of PKA by 3-isobutyl-1 methyl xanthine (IBMX) and forskolin enhances adipogenesis, the gene expression of PPARgamma2 and LPL, and downregulates the gene expression of Runx2 and osteopontin, markers of osteogenesis. Colforsin 98-107 lipoprotein lipase Danio rerio 169-172 18028338-9 2008 Comparison with forskolin- and nerve growth factor (NGF)-treated PC12 cells showed that CCK induced a separate set of target genes. Colforsin 16-25 cholecystokinin Rattus norvegicus 88-91 18160719-4 2008 We present evidence indicating that forskolin-induced binding of 14-3-3beta to beta(1)Pix results in inhibition of Rac1 GTP loading in 293 cells and in vitro. Colforsin 36-45 Rac family small GTPase 1 Homo sapiens 115-119 18156315-11 2008 In interleukin-4 pretreated, but not in naive Jurkat cells, the CB1 agonist R(+)-methanandamide caused a significant inhibition of forskolin-induced cAMP formation. Colforsin 131-140 interleukin 4 Homo sapiens 3-16 18156315-11 2008 In interleukin-4 pretreated, but not in naive Jurkat cells, the CB1 agonist R(+)-methanandamide caused a significant inhibition of forskolin-induced cAMP formation. Colforsin 131-140 cannabinoid receptor 1 Homo sapiens 64-67 17965877-6 2008 Orthophosphate labeling revealed that forskolin increased phosphorylation of wt-AQP2 and AQP2-E258K but not AQP2-S256A, indicating that the E258K mutation does not interfere with the AQP2 phosphorylation at S256. Colforsin 38-47 aquaporin 2 Canis lupus familiaris 80-84 17965877-6 2008 Orthophosphate labeling revealed that forskolin increased phosphorylation of wt-AQP2 and AQP2-E258K but not AQP2-S256A, indicating that the E258K mutation does not interfere with the AQP2 phosphorylation at S256. Colforsin 38-47 aquaporin 2 Canis lupus familiaris 89-93 17965877-6 2008 Orthophosphate labeling revealed that forskolin increased phosphorylation of wt-AQP2 and AQP2-E258K but not AQP2-S256A, indicating that the E258K mutation does not interfere with the AQP2 phosphorylation at S256. Colforsin 38-47 aquaporin 2 Canis lupus familiaris 89-93 17965877-6 2008 Orthophosphate labeling revealed that forskolin increased phosphorylation of wt-AQP2 and AQP2-E258K but not AQP2-S256A, indicating that the E258K mutation does not interfere with the AQP2 phosphorylation at S256. Colforsin 38-47 aquaporin 2 Canis lupus familiaris 89-93 18221935-10 2008 Treatment of glial cultures with forskolin or cAMP also increased iNOS expression and stimulated NO release to levels similar to CGRP. Colforsin 33-42 nitric oxide synthase 2 Rattus norvegicus 66-70 17973628-6 2008 This site was phosphorylated to a stoichiometry of up to 50% in HEK-293 cells expressing TPH2, and the enzyme activity and phosphorylation stoichiometry was further increased upon treatment with forskolin. Colforsin 195-204 tryptophan hydroxylase 2 Homo sapiens 89-93 18000164-5 2008 The addition of PACAP, VIP, or the adenylyl cyclase activator forskolin to CD34(+) cells inhibits megakaryocyte differentiation. Colforsin 62-71 CD34 antigen Mus musculus 75-79 18250418-6 2008 The inhibitory effect of PGE(2) on LPS-induced IFN-beta expression is mediated through PGE(2) receptor subtypes EP(2) and EP(4), and mimicked by the cAMP analog 8-Br-cAMP as well as by the adenylyl cyclase activator forskolin. Colforsin 216-225 interferon beta 1, fibroblast Mus musculus 47-55 18205818-6 2008 Furthermore, forskolin also inhibited the LPS-induced levels of TNF-alpha, IL-12 p40, IL-23 p19 and IL-6, supporting the hypothesis that the effects of NE are mediated by cAMP. Colforsin 13-22 tumor necrosis factor Homo sapiens 64-73 18205818-6 2008 Furthermore, forskolin also inhibited the LPS-induced levels of TNF-alpha, IL-12 p40, IL-23 p19 and IL-6, supporting the hypothesis that the effects of NE are mediated by cAMP. Colforsin 13-22 interleukin 9 Homo sapiens 81-84 18205818-6 2008 Furthermore, forskolin also inhibited the LPS-induced levels of TNF-alpha, IL-12 p40, IL-23 p19 and IL-6, supporting the hypothesis that the effects of NE are mediated by cAMP. Colforsin 13-22 interleukin 23 subunit alpha Homo sapiens 86-91 18205818-6 2008 Furthermore, forskolin also inhibited the LPS-induced levels of TNF-alpha, IL-12 p40, IL-23 p19 and IL-6, supporting the hypothesis that the effects of NE are mediated by cAMP. Colforsin 13-22 interleukin 23 subunit alpha Homo sapiens 92-95 18205818-6 2008 Furthermore, forskolin also inhibited the LPS-induced levels of TNF-alpha, IL-12 p40, IL-23 p19 and IL-6, supporting the hypothesis that the effects of NE are mediated by cAMP. Colforsin 13-22 interleukin 6 Homo sapiens 100-104 18189154-7 2008 In vitro treatment of differentiated primary pig preadipocytes with insulin and forskolin decreased ATGL gene expression in a dose-dependent manner, suggesting ATGL transcript levels are hormone sensitive. Colforsin 80-89 patatin like phospholipase domain containing 2 Sus scrofa 100-104 18189154-7 2008 In vitro treatment of differentiated primary pig preadipocytes with insulin and forskolin decreased ATGL gene expression in a dose-dependent manner, suggesting ATGL transcript levels are hormone sensitive. Colforsin 80-89 patatin like phospholipase domain containing 2 Sus scrofa 160-164 18253488-3 2008 METHODS AND FINDINGS: We report that activation of PKA by 3-isobutyl-1 methyl xanthine (IBMX) and forskolin enhances adipogenesis, the gene expression of PPARgamma2 and LPL, and downregulates the gene expression of Runx2 and osteopontin, markers of osteogenesis. Colforsin 98-107 secreted phosphoprotein 1 Danio rerio 225-236 17996730-5 2008 The GPR35 agonists kynurenic acid and zaprinast inhibited forskolin-stimulated cAMP production by cultured rat DRG neurons. Colforsin 58-67 G protein-coupled receptor 35 Rattus norvegicus 4-9 18006628-6 2008 Furthermore, overexpression of SRC1a, but not SRC1e, increased both efficacy and potency of the glucocorticoid receptor-mediated repression of the forskolin-induced CRH promoter. Colforsin 147-156 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 96-119 18006628-6 2008 Furthermore, overexpression of SRC1a, but not SRC1e, increased both efficacy and potency of the glucocorticoid receptor-mediated repression of the forskolin-induced CRH promoter. Colforsin 147-156 corticotropin releasing hormone Rattus norvegicus 165-168 18006628-7 2008 Unexpectedly, cotransfection of the corepressors N-CoR and SMRT did not affect the corticosterone-dependent repression but resulted in a marked decrease of the forskolin stimulation of the CRH gene. Colforsin 160-169 nuclear receptor co-repressor 1 Rattus norvegicus 49-54 18006628-7 2008 Unexpectedly, cotransfection of the corepressors N-CoR and SMRT did not affect the corticosterone-dependent repression but resulted in a marked decrease of the forskolin stimulation of the CRH gene. Colforsin 160-169 corticotropin releasing hormone Rattus norvegicus 189-192 18293188-13 2008 CONCLUSIONS: Forskolin prevents MLC phosphorylation induced by LPA, ET-1, and nocodazole through inhibition of RhoA-Rho kinase axis. Colforsin 13-22 ras homolog family member A Bos taurus 111-115 18076988-5 2008 RT-PCR analyses on stimulated BeWo cells or primary cytotrophoblast cells demonstrated an increase in syncytin-1 mRNA levels, which was more pronounced upon forskolin/bpV[pic] treatment. Colforsin 157-166 endogenous retrovirus group W member 1, envelope Homo sapiens 102-112 17989211-5 2008 Forskolin and rolipram (F/R) to increase cAMP and cytotoxic necrotizing factor 1 (CNF-1) to activate Rac 1 were equally efficient to stabilize barrier functions in VASP(-/-) and wild-type (wt) cells. Colforsin 0-9 vasodilator-stimulated phosphoprotein Mus musculus 164-168 17993590-4 2008 Activation of the cAMP-dependent signaling pathways by isoproterenol (ISO) or forskolin led to increases in the phosphorylation of HSP20 in GFP but not PKI-GFP cells. Colforsin 78-87 heat shock protein beta-6 Bos taurus 131-136 17913243-11 2008 Furthermore, incubation of monocytes with either the stable analogue of cAMP, dibutyryl cAMP, or forskolin, an activator of adenylyl cyclase, also inhibited LPS-induced production of TNF-alpha production by equine monocytes. Colforsin 97-106 tumor necrosis factor Equus caballus 183-192 17951372-7 2008 Similarly, the positive chronotropic response to the adenylate cyclase activator forskolin (10(-7)-10(-5) mol/l) was attenuated in nNOS(-/-) atria (P < 0.05). Colforsin 81-90 nitric oxide synthase 1, neuronal Mus musculus 131-135 18006600-5 2008 Forskolin stimulated PDE4D5 phosphorylation and PDE4D5 activity. Colforsin 0-9 phosphodiesterase 4D Homo sapiens 21-26 18006600-5 2008 Forskolin stimulated PDE4D5 phosphorylation and PDE4D5 activity. Colforsin 0-9 phosphodiesterase 4D Homo sapiens 48-53 17942071-10 2008 Forskolin, an adenylyl cyclase activator, activated the channel similarly as VIP. Colforsin 0-9 vasoactive intestinal peptide Homo sapiens 77-80 18006600-6 2008 CCK significantly increased forskolin-stimulated PDE4D5 phosphorylation and activity and attenuated forskolin-stimulated cAMP levels. Colforsin 28-37 cholecystokinin Homo sapiens 0-3 18006600-6 2008 CCK significantly increased forskolin-stimulated PDE4D5 phosphorylation and activity and attenuated forskolin-stimulated cAMP levels. Colforsin 28-37 phosphodiesterase 4D Homo sapiens 49-54 18006600-6 2008 CCK significantly increased forskolin-stimulated PDE4D5 phosphorylation and activity and attenuated forskolin-stimulated cAMP levels. Colforsin 100-109 cholecystokinin Homo sapiens 0-3 18006600-7 2008 The effect of CCK on forskolin-induced PDE4D5 phosphorylation and activity and on cAMP levels was blocked by the inhibitors of PLC or PKC and in cultured muscle cells by the expression of Galpha(q) minigene. Colforsin 21-30 cholecystokinin Homo sapiens 14-17 18006600-7 2008 The effect of CCK on forskolin-induced PDE4D5 phosphorylation and activity and on cAMP levels was blocked by the inhibitors of PLC or PKC and in cultured muscle cells by the expression of Galpha(q) minigene. Colforsin 21-30 phosphodiesterase 4D Homo sapiens 39-44 18065431-11 2008 The pigment phenotype was rescued by application of forskolin, an activator of adenylyl cyclase, suggesting that the synbl gene activates the Galpha(S) pathway leading to activation of adenylyl cyclase. Colforsin 52-61 RIC8 guanine nucleotide exchange factor B Danio rerio 117-122 19088454-9 2008 Similarly, treatment with 5 microM forskolin as well as stimulation of protein kinase C with phorbolester phorbol 12 myristate 13 acetate (100 nM) enhanced DeltapH/min to almost identical values in pdk1(hm) and in pdk1(wt)mice. Colforsin 35-44 pyruvate dehydrogenase kinase, isoenzyme 1 Mus musculus 198-206 19088454-9 2008 Similarly, treatment with 5 microM forskolin as well as stimulation of protein kinase C with phorbolester phorbol 12 myristate 13 acetate (100 nM) enhanced DeltapH/min to almost identical values in pdk1(hm) and in pdk1(wt)mice. Colforsin 35-44 pyruvate dehydrogenase kinase, isoenzyme 1 Mus musculus 198-202 17916627-4 2008 This study reports the expression of the CNGA2 subunit in GnRH-1 neurons obtained from mouse nasal explants and shows the ability of GnRH-1 neurons to increase their activity in response to forskolin (activator of adenylyl cyclases), or 3-isobutyl-1-methylxanthine (inhibitor of phosphodiesterases) even after removal of gamma-aminobutyric acid (A)-ergic input. Colforsin 190-199 cyclic nucleotide gated channel alpha 2 Mus musculus 41-46 17916627-4 2008 This study reports the expression of the CNGA2 subunit in GnRH-1 neurons obtained from mouse nasal explants and shows the ability of GnRH-1 neurons to increase their activity in response to forskolin (activator of adenylyl cyclases), or 3-isobutyl-1-methylxanthine (inhibitor of phosphodiesterases) even after removal of gamma-aminobutyric acid (A)-ergic input. Colforsin 190-199 gonadotropin releasing hormone 1 Mus musculus 133-139 18769032-3 2008 Forskolin-stimulated Cl secretion in two clones expressing the full-length wild type CFTR was assessed; clone c7-6.2wt gave 13.4+/-2.5 microA/cm(2) and clone c10-6.2wt showed 41.3+/-25.3 microA/cm(2). Colforsin 0-9 CF transmembrane conductance regulator Homo sapiens 85-89 19091080-10 2008 In CD14+ monocytes of patients with septic shock, the anti-inflammatory effect of isoprenaline was completely blunted whereas efficacy of forskolin and rolipram was maintained. Colforsin 138-147 CD14 molecule Homo sapiens 3-7 18335579-5 2008 The activation of adenylate cyclase by forskolin enhanced cAMP and PCK1 mRNA. Colforsin 39-48 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 67-71 17949246-3 2008 We also evaluated the dose response for forskolin- and nitroglycerin-induced relaxation in phenylephrine-stimulated PLM-/- and PLM+/+ mice. Colforsin 40-49 FXYD domain-containing ion transport regulator 1 Mus musculus 116-119 17959714-3 2008 Mrp4 deficiency caused decreased extracellular and increased intracellular levels of cAMP in MEF cells under normal and forskolin-stimulated conditions. Colforsin 120-129 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus 0-4 17763866-5 2008 Upon forskolin addition, net Na(+) absorption decreased, Isc strongly increased, and net Cl(-) flux became secretory in Slc26a6-/- and +/+ jejuni. Colforsin 5-14 solute carrier family 26, member 6 Mus musculus 120-127 17995938-7 2008 As observed with PACAP-38, the adenylyl cyclase activator, forskolin, also induced an increase in the number of neurite-bearing cells and an up-regulation in the expression of Bcl-2 and GAP-43. Colforsin 59-68 adenylate cyclase activating polypeptide 1 Homo sapiens 17-22 17995938-7 2008 As observed with PACAP-38, the adenylyl cyclase activator, forskolin, also induced an increase in the number of neurite-bearing cells and an up-regulation in the expression of Bcl-2 and GAP-43. Colforsin 59-68 BCL2 apoptosis regulator Homo sapiens 176-181 17995938-7 2008 As observed with PACAP-38, the adenylyl cyclase activator, forskolin, also induced an increase in the number of neurite-bearing cells and an up-regulation in the expression of Bcl-2 and GAP-43. Colforsin 59-68 growth associated protein 43 Homo sapiens 186-192 17995938-9 2008 PACAP-38 and forskolin stimulated the activation of extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAP; p38 MAP kinase) and c-Jun N-terminal kinase (JNK). Colforsin 13-22 mitogen-activated protein kinase 1 Homo sapiens 52-89 17995938-9 2008 PACAP-38 and forskolin stimulated the activation of extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAP; p38 MAP kinase) and c-Jun N-terminal kinase (JNK). Colforsin 13-22 mitogen-activated protein kinase 1 Homo sapiens 91-94 17995938-9 2008 PACAP-38 and forskolin stimulated the activation of extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAP; p38 MAP kinase) and c-Jun N-terminal kinase (JNK). Colforsin 13-22 mitogen-activated protein kinase 14 Homo sapiens 136-150 17995938-9 2008 PACAP-38 and forskolin stimulated the activation of extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAP; p38 MAP kinase) and c-Jun N-terminal kinase (JNK). Colforsin 13-22 mitogen-activated protein kinase 8 Homo sapiens 156-179 17995938-9 2008 PACAP-38 and forskolin stimulated the activation of extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAP; p38 MAP kinase) and c-Jun N-terminal kinase (JNK). Colforsin 13-22 mitogen-activated protein kinase 8 Homo sapiens 181-184 17681645-6 2008 BDNF levels in astrocytes were increased by the specific beta1-adrenergic agonist dobutamine and the beta2-adrenergic agonist salbutamol, as well as by adenylate cyclase activation (by forskolin) and PKA activation (by dBcAMP). Colforsin 185-194 brain-derived neurotrophic factor Rattus norvegicus 0-4 17949246-4 2008 The time course for changes in ser19 MRLC dephosphorylation and ser16 HSP20 phosphorylation was appropriate to explain the forskolin-induced relaxation and the recontraction observed upon washout of forskolin. Colforsin 123-132 HSPB6 Sus scrofa 70-75 17949246-4 2008 The time course for changes in ser19 MRLC dephosphorylation and ser16 HSP20 phosphorylation was appropriate to explain the forskolin-induced relaxation and the recontraction observed upon washout of forskolin. Colforsin 199-208 HSPB6 Sus scrofa 70-75 17949246-8 2008 These data are consistent with the hypothesis that ser19 MRLC dephosphorylation and ser16 HSP20 phosphorylation are involved in forskolin-induced relaxation. Colforsin 128-137 HSPB6 Sus scrofa 90-95 17699734-10 2007 Occupancy of the endogenous promoter by EGR1 was increased by GnRH1 with or without forskolin, but forskolin alone had little effect. Colforsin 84-93 early growth response 1 Mus musculus 40-44 17932048-5 2007 Hormonal stimulation of ENaC activity by either forskolin or aldosterone, short or long term, did not alter the lipid raft distribution of ENaC. Colforsin 48-57 sodium channel, nonvoltage-gated 1 alpha Mus musculus 24-28 17964608-3 2007 We examined the role of beta(2)-agonists, cAMP analogs, and forskolin (an activator of adenylate cyclase) on TTP mRNA and protein expression by quantitative real-time RT-PCR and Western blotting in J774 murine macrophages and THP-1 human macrophages. Colforsin 60-69 zinc finger protein 36 Mus musculus 109-112 17925456-6 2007 Expression of a dominant-negative form of CREB (MCREB), which was effective in suppressing CRE-mediated transcription induced by the adenylate cyclase activator forskolin, inhibited basal and forskolin-induced PRL promoter activity and PRL mRNA expression. Colforsin 161-170 cAMP responsive element binding protein 1 Rattus norvegicus 42-46 17925456-6 2007 Expression of a dominant-negative form of CREB (MCREB), which was effective in suppressing CRE-mediated transcription induced by the adenylate cyclase activator forskolin, inhibited basal and forskolin-induced PRL promoter activity and PRL mRNA expression. Colforsin 192-201 cAMP responsive element binding protein 1 Rattus norvegicus 42-46 17932048-10 2007 Expression of dominant negative caveolin isoforms (CAV1-eGFP and CAV3-DGV) which disrupt caveolae, reduced basal ENaC currents by 72.3 and 78.2%, respectively; but, as with cyclodextrin, the acute response to forskolin was unaffected. Colforsin 209-218 caveolin 1, caveolae protein Mus musculus 32-40 17932048-10 2007 Expression of dominant negative caveolin isoforms (CAV1-eGFP and CAV3-DGV) which disrupt caveolae, reduced basal ENaC currents by 72.3 and 78.2%, respectively; but, as with cyclodextrin, the acute response to forskolin was unaffected. Colforsin 209-218 caveolin 1, caveolae protein Mus musculus 51-55 17938178-8 2007 Activation of PKA (using forskolin) differentially potentiated apical [Ca(2+)](i) clearance in mouse parotid acinar cells and apical PMCA activity in Par-C10 cells. Colforsin 25-34 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 14-17 17888871-5 2007 This short-term estrogen treatment also significantly enhanced forskolin stimulated cAMP production when compared with the ratio of cAMP/Total measured in cells stimulated with forskolin alone. Colforsin 63-72 cathelicidin antimicrobial peptide Homo sapiens 84-88 17849471-6 2007 Forskolin with serum promotes G1 progression in 22% of Schwann cells between 18 and 24 h by inducing a steady decline in p27(Kip) levels that reaches a nadir at 12 h coinciding with peak cyclin E1 expression. Colforsin 0-9 cyclin E1 Homo sapiens 187-196 17849471-7 2007 Forskolin also delays neuregulin-induced loss of erbB2 receptors allowing strong acute activation of PI3K, sustained erbB2 phosphorylation and G1 progression in 31% of Schwann cells. Colforsin 0-9 erb-b2 receptor tyrosine kinase 2 Homo sapiens 49-54 17849471-7 2007 Forskolin also delays neuregulin-induced loss of erbB2 receptors allowing strong acute activation of PI3K, sustained erbB2 phosphorylation and G1 progression in 31% of Schwann cells. Colforsin 0-9 erb-b2 receptor tyrosine kinase 2 Homo sapiens 117-122 17849471-8 2007 We find that the ability of forskolin to decrease p27(Kip) is associated with its ability to decrease Krox-20 expression that is induced by serum and further increased by neuregulin. Colforsin 28-37 interferon alpha inducible protein 27 Homo sapiens 50-53 17849471-8 2007 We find that the ability of forskolin to decrease p27(Kip) is associated with its ability to decrease Krox-20 expression that is induced by serum and further increased by neuregulin. Colforsin 28-37 early growth response 2 Homo sapiens 102-109 18024890-8 2007 Using [35S]GTPgammaS and reporter gene assays, we found that A5 is able to constitutively couple to alpha i-type G-proteins in transfected cells, and that this interaction is able to inhibit forskolin-triggered cAMP response element-binding protein (CREB) activation. Colforsin 191-200 cAMP responsive element binding protein 1 Homo sapiens 211-248 18024890-8 2007 Using [35S]GTPgammaS and reporter gene assays, we found that A5 is able to constitutively couple to alpha i-type G-proteins in transfected cells, and that this interaction is able to inhibit forskolin-triggered cAMP response element-binding protein (CREB) activation. Colforsin 191-200 cAMP responsive element binding protein 1 Homo sapiens 250-254 17584514-10 2007 Insulin secretion was increased by leucine+glutamine, arginine, alanine or a mixture of amino acids, but their effect was significant only in the presence of forskolin. Colforsin 158-167 insulin Sus scrofa 0-7 17849471-0 2007 Serum and forskolin cooperate to promote G1 progression in Schwann cells by differentially regulating cyclin D1, cyclin E1, and p27Kip expression. Colforsin 10-19 cyclin D1 Homo sapiens 102-111 17849471-0 2007 Serum and forskolin cooperate to promote G1 progression in Schwann cells by differentially regulating cyclin D1, cyclin E1, and p27Kip expression. Colforsin 10-19 cyclin E1 Homo sapiens 113-122 17849471-6 2007 Forskolin with serum promotes G1 progression in 22% of Schwann cells between 18 and 24 h by inducing a steady decline in p27(Kip) levels that reaches a nadir at 12 h coinciding with peak cyclin E1 expression. Colforsin 0-9 interferon alpha inducible protein 27 Homo sapiens 121-124 17964599-8 2007 Intriguingly, prior exposure to the adenylyl cyclase activator forskolin (1 microM for 5 min) or the beta-adrenergic agonist isoprenaline (100 nM for 5 min) markedly attenuated ET1-induced PKD activation, but not PMA-induced PKD activation. Colforsin 63-72 endothelin 1 Rattus norvegicus 177-180 17882384-7 2007 Earlier studies indicated that forskolin might affect insulin-stimulated GLUT4 translocation. Colforsin 31-40 solute carrier family 2 member 4 Rattus norvegicus 73-78 17882384-9 2007 Forskolin and dipyridamole are more potent inhibitors of GLUT4 than GLUT1. Colforsin 0-9 solute carrier family 2 member 4 Rattus norvegicus 57-62 17882384-9 2007 Forskolin and dipyridamole are more potent inhibitors of GLUT4 than GLUT1. Colforsin 0-9 solute carrier family 2 member 1 Rattus norvegicus 68-73 17888871-6 2007 Pre-treating MCF7 cells with the same concentration of estrogen for 24h before the assay, on the contrary, significantly decreased the basal cAMP level and it also suppressed cAMP production stimulated with forskolin when compared with its respective value under short-term estrogen treatment. Colforsin 207-216 cathelicidin antimicrobial peptide Homo sapiens 175-179 17907296-2 2007 METHODS: The ARIP2 mRNA expression kinetics in Hepal-6 cells was detected by RT-PCR, and its regulation factors were analyzed by treatment with signal transduction activators such as phorbol 12-myristate 13-acetate (PMA), forskolin and A23187. Colforsin 222-231 synaptojanin 2 binding protein Mus musculus 13-18 17618452-9 2007 Carbachol (100 microM) and forskolin (5 microM) stimulated gastric acid secretion to a similar extent in sgk1 (-/-) and sgk1 (+/+)mice. Colforsin 27-36 serum/glucocorticoid regulated kinase 1 Mus musculus 105-109 17618452-9 2007 Carbachol (100 microM) and forskolin (5 microM) stimulated gastric acid secretion to a similar extent in sgk1 (-/-) and sgk1 (+/+)mice. Colforsin 27-36 serum/glucocorticoid regulated kinase 1 Mus musculus 120-124 17907296-5 2007 The ARIP2 mRNA expression was increased after stimulated with signal transduction activators such as PMA and forskolin in Hepal-6 cells, whereas decreased after treatment with A23187 (25.3% +/- 5.7% vs 48.1% +/- 3.6%, P < 0.01). Colforsin 109-118 synaptojanin 2 binding protein Mus musculus 4-9 17636039-7 2007 PGE2 is a known activator of the cAMP/protein kinase A (PKA) pathway, and in T47D cells, up-regulation of SOCS3 mRNA by PGE2 was abolished by pretreatment with H89, a PKA inhibitor and increased by cAMP and forskolin treatment. Colforsin 207-216 suppressor of cytokine signaling 3 Homo sapiens 106-111 17785468-3 2007 The nonfatty acid binding mutant of AFABP/aP2 (R126Q) failed to form a FRET-competent complex with HSL either under basal or forskolin-stimulated conditions, indicating that lipid binding is required for association. Colforsin 125-134 fatty acid binding protein 4, adipocyte Mus musculus 36-41 17785468-3 2007 The nonfatty acid binding mutant of AFABP/aP2 (R126Q) failed to form a FRET-competent complex with HSL either under basal or forskolin-stimulated conditions, indicating that lipid binding is required for association. Colforsin 125-134 fatty acid binding protein 4, adipocyte Mus musculus 42-45 17916355-10 2007 The effect of forskolin on luminal pH was reduced by a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor and by siRNA for the type III InsP3R. Colforsin 14-23 CF transmembrane conductance regulator Rattus norvegicus 55-106 17916355-10 2007 The effect of forskolin on luminal pH was reduced by a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor and by siRNA for the type III InsP3R. Colforsin 14-23 CF transmembrane conductance regulator Rattus norvegicus 108-112 17916355-10 2007 The effect of forskolin on luminal pH was reduced by a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor and by siRNA for the type III InsP3R. Colforsin 14-23 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 154-160 17951532-5 2007 In 4B cells transfected with either a CRF or an AVP promoter-luciferase construct, forskolin increased the transcriptional activity of CRF or AVP. Colforsin 83-92 arginine vasopressin Homo sapiens 48-51 17951532-5 2007 In 4B cells transfected with either a CRF or an AVP promoter-luciferase construct, forskolin increased the transcriptional activity of CRF or AVP. Colforsin 83-92 arginine vasopressin Homo sapiens 142-145 17427962-12 2007 We further demonstrated that the adenylate cyclase activator forskolin and the cAMP anologue 8-bromo-cAMP mimicked the effects of PGE2 on VEGF secretion in PC-3 cells. Colforsin 61-70 vascular endothelial growth factor A Homo sapiens 138-142 17707335-4 2007 In addition, PUGNAc, an inhibitor of O-GlcNAcase, potentiated the expression of osteocalcin caused by ascorbic acid, parathyroid hormone (PTH) and forskolin. Colforsin 147-156 O-GlcNAcase Homo sapiens 37-48 17707335-4 2007 In addition, PUGNAc, an inhibitor of O-GlcNAcase, potentiated the expression of osteocalcin caused by ascorbic acid, parathyroid hormone (PTH) and forskolin. Colforsin 147-156 bone gamma-carboxyglutamate protein Homo sapiens 80-91 17704206-5 2007 When cAMP synthesis was slightly elevated with a submaximal concentration of 7-deacetyl-7-(O-[N-methylpiperazino]-gamma-butyryl)-dihydrochloride-forskolin (MPB-forskolin), we found that low doses of either atrial natriuretic peptide (ANP) or NO donors potentiated the inhibitory effects of MPB-forskolin on thrombin-induced permeability. Colforsin 145-154 coagulation factor II, thrombin Homo sapiens 307-315 17582383-3 2007 Charge-neutralizing mutations K978A, K978Q, K978S abolished the inhibition of forskolin-activated CFTR chloride current by glibenclamide but not by CFTR(inh)-172. Colforsin 78-87 CF transmembrane conductance regulator Homo sapiens 98-102 17894822-1 2007 Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) was investigated in Calu-6 and Cos-7 cells under the influence of 4beta-phorbol 12-myristate 13-acetate (PMA), forskolin, dioxin and the heavy metals copper, nickel and cobalt. Colforsin 204-213 tumor protein, translationally-controlled 1 Homo sapiens 24-28 17894822-1 2007 Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) was investigated in Calu-6 and Cos-7 cells under the influence of 4beta-phorbol 12-myristate 13-acetate (PMA), forskolin, dioxin and the heavy metals copper, nickel and cobalt. Colforsin 204-213 tumor protein, translationally-controlled 1 Homo sapiens 45-85 17894822-3 2007 PMA, forskolin, dioxin, cobalt and nickel induced TCTP expression in 24 h in both cell lines about 2.2-3.2-fold at the mRNA level and 1.6-2.2-fold at the protein level. Colforsin 5-14 tumor protein, translationally-controlled 1 Homo sapiens 50-54 17894822-5 2007 TPT1 promoter assays showed transcriptional activation by PMA, forskolin and dioxin (2.0-3.1-fold) and a 7.0-8.0-fold increase by copper, whereas cobalt and nickel had no effect. Colforsin 63-72 tumor protein, translationally-controlled 1 Homo sapiens 0-4 17407158-6 2007 In addition, forskolin (PKA activator) stimulated MGP promoter activity and mRNA levels confirming that PKA is one of the signaling molecules required for regulation of MGP by PTH. Colforsin 13-22 matrix Gla protein Mus musculus 50-53 17407158-6 2007 In addition, forskolin (PKA activator) stimulated MGP promoter activity and mRNA levels confirming that PKA is one of the signaling molecules required for regulation of MGP by PTH. Colforsin 13-22 matrix Gla protein Mus musculus 169-172 17407158-6 2007 In addition, forskolin (PKA activator) stimulated MGP promoter activity and mRNA levels confirming that PKA is one of the signaling molecules required for regulation of MGP by PTH. Colforsin 13-22 parathyroid hormone Mus musculus 176-179 17029675-3 2007 Forskolin increased IGFBP-3 gene expression and media content of BP-3 protein. Colforsin 0-9 insulin like growth factor binding protein 3 Bos taurus 20-27 17596272-8 2007 Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172. Colforsin 64-73 CF transmembrane conductance regulator Rattus norvegicus 162-166 17596272-8 2007 Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172. Colforsin 64-73 CF transmembrane conductance regulator Rattus norvegicus 187-191 17596272-8 2007 Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172. Colforsin 64-73 CF transmembrane conductance regulator Rattus norvegicus 187-191 17596272-8 2007 Furthermore, the following effects were found: 1) inhibition of forskolin/genistein-activated iodide efflux by glibenclamide, diphenylamine-2-carboxylic acid and CFTR-specific inhibitor (CFTR(inh))-172; 2) activation of iodide efflux by the benzoquinolizinium derivative CFTR activators MPB-07 and MPB-91; and 3) inhibition of MPB-dependent efflux by CFTR(inh)-172. Colforsin 64-73 CF transmembrane conductance regulator Rattus norvegicus 187-191 17942733-9 2007 In cortical neurons, ERK1/2 activation by forskolin was protein kinase A (PKA) dependent but TrkB (receptor tyrosine kinase B) independent and was accompanied by the increased association between KSR1 and active ERK1/2. Colforsin 42-51 mitogen activated protein kinase 3 Rattus norvegicus 21-27 17942733-9 2007 In cortical neurons, ERK1/2 activation by forskolin was protein kinase A (PKA) dependent but TrkB (receptor tyrosine kinase B) independent and was accompanied by the increased association between KSR1 and active ERK1/2. Colforsin 42-51 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 56-72 17942733-9 2007 In cortical neurons, ERK1/2 activation by forskolin was protein kinase A (PKA) dependent but TrkB (receptor tyrosine kinase B) independent and was accompanied by the increased association between KSR1 and active ERK1/2. Colforsin 42-51 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 74-77 17942733-9 2007 In cortical neurons, ERK1/2 activation by forskolin was protein kinase A (PKA) dependent but TrkB (receptor tyrosine kinase B) independent and was accompanied by the increased association between KSR1 and active ERK1/2. Colforsin 42-51 kinase suppressor of ras 1 Rattus norvegicus 196-200 17942733-9 2007 In cortical neurons, ERK1/2 activation by forskolin was protein kinase A (PKA) dependent but TrkB (receptor tyrosine kinase B) independent and was accompanied by the increased association between KSR1 and active ERK1/2. Colforsin 42-51 mitogen activated protein kinase 3 Rattus norvegicus 212-218 17942733-10 2007 Forskolin suppressed CPT-induced apoptosis in a KSR1 and ERK1/2-dependent manner. Colforsin 0-9 kinase suppressor of ras 1 Rattus norvegicus 48-52 17942733-10 2007 Forskolin suppressed CPT-induced apoptosis in a KSR1 and ERK1/2-dependent manner. Colforsin 0-9 mitogen activated protein kinase 3 Rattus norvegicus 57-63 18000336-9 2007 The forskolin-induced J(OH) value and PD were both inhibited by NPPB and probably also by tenidap. Colforsin 4-13 natriuretic peptide type B Mus musculus 64-68 17637798-7 2007 Isolated trachea from neonatal CF mice expressing the FOXJ1/CFTR transgene demonstrated a correction of forskolin-stimulated Cl(-) secretion. Colforsin 104-113 forkhead box J1 Mus musculus 54-59 17637798-7 2007 Isolated trachea from neonatal CF mice expressing the FOXJ1/CFTR transgene demonstrated a correction of forskolin-stimulated Cl(-) secretion. Colforsin 104-113 cystic fibrosis transmembrane conductance regulator Mus musculus 60-64 17938542-8 2007 Intracellular concentration of cAMP was significantly increased after cilostazol treatment, and treatment with Forskolin and Dibutyryl-cAMP, potent inducers of cAMP, dramatically increased THP-1 adhesion to HUVECs. Colforsin 111-120 GLI family zinc finger 2 Homo sapiens 189-194 17609420-7 2007 In CHO cells expressing rat mGluR7, MDIP and MMPIP inhibited l-AP4-induced inhibition of forskolin-stimulated cAMP accumulation (IC50 = 99 and 220 nM). Colforsin 89-98 glutamate receptor, ionotropic, kainate 3 Mus musculus 28-34 17609420-11 2007 In the absence of these agonists, MMPIP caused a further increase in forskolin-stimulated cAMP levels in CHO cells expressing mGluR7, whereas a competitive antagonist, LY341495, did not. Colforsin 69-78 glutamate receptor, ionotropic, kainate 3 Mus musculus 126-132 17616391-0 2007 In CEM cells the autosomal deafness gene dfna5 is regulated by glucocorticoids and forskolin. Colforsin 83-92 gasdermin E Homo sapiens 41-46 17595323-10 2007 Treatment of cumulus oocyte complexes or granulosa cells with FSH/amphiregulin, LH, or forskolin/phorbol 12-myristate 13-acetate-induced elevated expression of Snap25 mRNA and increased the secretion of eight cytokine and chemokine factors. Colforsin 87-96 synaptosomal-associated protein 25 Mus musculus 160-166 17460731-2 2007 We have assessed the contribution of MITF to pigmentation regulation by treating primary cultures of normal human melanocytes with the adenylate cyclase activator forskolin and/or resveratrol, then quantifying mRNA and protein levels for MITF, tyrosinase, tyrosinase-related protein-1, and dopachrome tautomerase (DCT). Colforsin 163-172 melanocyte inducing transcription factor Homo sapiens 37-41 17895835-5 2007 Protein kinase A inhibition by H89 blocked forskolin-evoked robust-sustained hotspots, while retaining multiphasic (47%) and monophasic (53%) hotspots. Colforsin 43-52 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-16 17697115-7 2007 Under conditions of enhanced intracellular Ca(2+) concentration, a rapid increase in cAMP levels caused by the adenylyl cyclase activator forskolin was abolished, indicating the involvement of Ca(2+)-activated phosphodiesterase 1C. Colforsin 138-147 phosphodiesterase 1C Homo sapiens 210-230 17626240-9 2007 After internalization of AQP2, induced by removal of AVP, forskolin triggered the AQP2 redistribution to the plasma membrane even if microtubules were depolymerized and without the previous positioning of AQP2 in the perinuclear recycling compartment. Colforsin 58-67 aquaporin 2 Rattus norvegicus 25-29 17626240-9 2007 After internalization of AQP2, induced by removal of AVP, forskolin triggered the AQP2 redistribution to the plasma membrane even if microtubules were depolymerized and without the previous positioning of AQP2 in the perinuclear recycling compartment. Colforsin 58-67 aquaporin 2 Rattus norvegicus 82-86 17626240-9 2007 After internalization of AQP2, induced by removal of AVP, forskolin triggered the AQP2 redistribution to the plasma membrane even if microtubules were depolymerized and without the previous positioning of AQP2 in the perinuclear recycling compartment. Colforsin 58-67 aquaporin 2 Rattus norvegicus 82-86 17626241-5 2007 Similar effects were obtained following downregulation of GATA-6 by forskolin-induced elevation of intracellular cAMP levels. Colforsin 68-77 GATA binding protein 6 Homo sapiens 58-64 17626241-6 2007 Forskolin treatment of pBSMC abolished recruitment of GATA-6 to the alpha-SMA promoter in vivo and reduced activity of human alpha-SMA promoter-directed gene expression by >60%. Colforsin 0-9 GATA binding protein 6 Homo sapiens 54-60 17460731-5 2007 Elevation of intracellular cAMP by forskolin markedly increased protein levels for MITF, tyrosinase and DCT, however there was no concomitant increase in tyrosinase or DCT mRNA. Colforsin 35-44 melanocyte inducing transcription factor Homo sapiens 83-87 17460731-5 2007 Elevation of intracellular cAMP by forskolin markedly increased protein levels for MITF, tyrosinase and DCT, however there was no concomitant increase in tyrosinase or DCT mRNA. Colforsin 35-44 tyrosinase Homo sapiens 89-99 17460731-5 2007 Elevation of intracellular cAMP by forskolin markedly increased protein levels for MITF, tyrosinase and DCT, however there was no concomitant increase in tyrosinase or DCT mRNA. Colforsin 35-44 dopachrome tautomerase Homo sapiens 104-107 17565009-11 2007 Overexpression of Epac1 enhanced A(2B)AR-mediated and forskolin-induced ERK1/2 phosphorylation, whereas response to VEGF was unaffected. Colforsin 54-63 Rap guanine nucleotide exchange factor 3 Homo sapiens 18-23 17565009-13 2007 A(2B)AR stimulation and forskolin activated Rap1. Colforsin 24-33 RAP1A, member of RAS oncogene family Homo sapiens 44-48 17586724-3 2007 WAY-132983 also activated the M(4) receptor, fully inhibiting forskolin-induced increase in cAMP levels (IC(50) = 10.5 nM); at the M(2) receptor its potency was reduced by 5-fold (IC(50) = 49.8 nM). Colforsin 62-71 cathelicidin antimicrobial peptide Homo sapiens 92-96 17565009-11 2007 Overexpression of Epac1 enhanced A(2B)AR-mediated and forskolin-induced ERK1/2 phosphorylation, whereas response to VEGF was unaffected. Colforsin 54-63 mitogen-activated protein kinase 3 Homo sapiens 72-78 17565009-12 2007 Inhibition of Epac1 expression with small interfering RNA substantially reduced A(2B)AR-mediated and forskolin-induced ERK1/2 phosphorylation and abolished that by 8CPT-2Me-cAMP. Colforsin 101-110 Rap guanine nucleotide exchange factor 3 Homo sapiens 14-19 17565009-12 2007 Inhibition of Epac1 expression with small interfering RNA substantially reduced A(2B)AR-mediated and forskolin-induced ERK1/2 phosphorylation and abolished that by 8CPT-2Me-cAMP. Colforsin 101-110 mitogen-activated protein kinase 3 Homo sapiens 119-125 17581860-4 2007 Cell stimulation with forskolin/3-isobutyl-1-methylxanthine significantly increases the amount of anx 2-S100A10 that reciprocally coimmunoprecipitates with cell surface CFTR and calyculin A. Preinhibition with PKA or CaN inhibitors attenuates the interaction. Colforsin 22-31 annexin A2 Homo sapiens 98-103 17578899-3 2007 In whole-cell patch-clamp experiments of Chinese hamster ovary (CHO) cells expressing WT-CFTR, we recorded rapid and reversible inhibition of forskolin-activated CFTR currents in the presence of the adducts 5a and 8a,b at 10 pM concentrations. Colforsin 142-151 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 89-93 17578899-3 2007 In whole-cell patch-clamp experiments of Chinese hamster ovary (CHO) cells expressing WT-CFTR, we recorded rapid and reversible inhibition of forskolin-activated CFTR currents in the presence of the adducts 5a and 8a,b at 10 pM concentrations. Colforsin 142-151 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 162-166 17578899-8 2007 Finally, we found comparable inhibition by 5a or by CFTR(inh)-172 of forskolin-dependent short-circuit currents in mouse colon. Colforsin 69-78 cystic fibrosis transmembrane conductance regulator Mus musculus 52-56 17581860-4 2007 Cell stimulation with forskolin/3-isobutyl-1-methylxanthine significantly increases the amount of anx 2-S100A10 that reciprocally coimmunoprecipitates with cell surface CFTR and calyculin A. Preinhibition with PKA or CaN inhibitors attenuates the interaction. Colforsin 22-31 CF transmembrane conductance regulator Homo sapiens 169-173 17614108-2 2007 In a previous report, we found that forskolin (FSK) synergistically induces aromatase (CYP19: a rate-limiting enzyme for estrogen synthesis) expression in dexamethasone (Dex) dependent manner in a human osteoblastic cell line, SV-HFO [Watanabe M, Ohno S, Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 36-45 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 76-85 17614108-2 2007 In a previous report, we found that forskolin (FSK) synergistically induces aromatase (CYP19: a rate-limiting enzyme for estrogen synthesis) expression in dexamethasone (Dex) dependent manner in a human osteoblastic cell line, SV-HFO [Watanabe M, Ohno S, Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 36-45 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 87-92 17614108-2 2007 In a previous report, we found that forskolin (FSK) synergistically induces aromatase (CYP19: a rate-limiting enzyme for estrogen synthesis) expression in dexamethasone (Dex) dependent manner in a human osteoblastic cell line, SV-HFO [Watanabe M, Ohno S, Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 36-45 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 317-326 17614108-2 2007 In a previous report, we found that forskolin (FSK) synergistically induces aromatase (CYP19: a rate-limiting enzyme for estrogen synthesis) expression in dexamethasone (Dex) dependent manner in a human osteoblastic cell line, SV-HFO [Watanabe M, Ohno S, Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 36-45 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 328-333 17614108-2 2007 In a previous report, we found that forskolin (FSK) synergistically induces aromatase (CYP19: a rate-limiting enzyme for estrogen synthesis) expression in dexamethasone (Dex) dependent manner in a human osteoblastic cell line, SV-HFO [Watanabe M, Ohno S, Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 47-50 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 76-85 17614108-2 2007 In a previous report, we found that forskolin (FSK) synergistically induces aromatase (CYP19: a rate-limiting enzyme for estrogen synthesis) expression in dexamethasone (Dex) dependent manner in a human osteoblastic cell line, SV-HFO [Watanabe M, Ohno S, Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 47-50 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 87-92 17614108-2 2007 In a previous report, we found that forskolin (FSK) synergistically induces aromatase (CYP19: a rate-limiting enzyme for estrogen synthesis) expression in dexamethasone (Dex) dependent manner in a human osteoblastic cell line, SV-HFO [Watanabe M, Ohno S, Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 47-50 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 317-326 17614108-2 2007 In a previous report, we found that forskolin (FSK) synergistically induces aromatase (CYP19: a rate-limiting enzyme for estrogen synthesis) expression in dexamethasone (Dex) dependent manner in a human osteoblastic cell line, SV-HFO [Watanabe M, Ohno S, Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 47-50 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 328-333 17614108-2 2007 In a previous report, we found that forskolin (FSK) synergistically induces aromatase (CYP19: a rate-limiting enzyme for estrogen synthesis) expression in dexamethasone (Dex) dependent manner in a human osteoblastic cell line, SV-HFO [Watanabe M, Ohno S, Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 266-275 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 76-85 17614108-2 2007 In a previous report, we found that forskolin (FSK) synergistically induces aromatase (CYP19: a rate-limiting enzyme for estrogen synthesis) expression in dexamethasone (Dex) dependent manner in a human osteoblastic cell line, SV-HFO [Watanabe M, Ohno S, Nakajin S. Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 266-275 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 87-92 17507604-7 2007 Although forskolin (100 microM; an activator of adenylyl cyclase) elicited a moderate increase in [Ca(2+)](i), neither preincubation with the adenylyl cyclase inhibitor 2"-5"-dideoxyadenosine (50 microM) nor the protein kinase A (PKA) inhibitor PKA(14-22) (100 microM) significantly inhibited peak [Ca(2+)](i) in response to AVP. Colforsin 9-18 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 212-228 17574328-7 2007 Finally, ectopic expression of Nur77 markedly suppressed forskolin-induced transcriptional activation of promoters I.3 and II of the CYP19 gene. Colforsin 57-66 nuclear receptor subfamily 4 group A member 1 Homo sapiens 31-36 17574328-7 2007 Finally, ectopic expression of Nur77 markedly suppressed forskolin-induced transcriptional activation of promoters I.3 and II of the CYP19 gene. Colforsin 57-66 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 133-138 17992606-6 2007 Addition of H89 or U0126, both inhibited the testosterone-, FSH-, and forskolin-induced tPA expression. Colforsin 70-79 plasminogen activator, tissue type Rattus norvegicus 88-91 17472573-5 2007 Secretion in response to thrombin, a protease-activated receptor-1 agonist peptide, histamine, forskolin and adrenaline (epinephrine) was inhibited. Colforsin 95-104 coagulation factor II, thrombin Homo sapiens 25-33 17472573-13 2007 DNCdc42 conferred inhibition of thrombin- and forskolin-induced vWF secretion. Colforsin 46-55 von Willebrand factor Homo sapiens 64-67 17603556-6 2007 Sch35966 is an agonist as it effectively inhibited forskolin-stimulated cAMP synthesis in CHO-hCB(2) cells, stimulated [(35)S]GTPgammaS exchange and directed chemotaxis in cell membranes expressing CB(2). Colforsin 51-60 cannabinoid receptor 2 Homo sapiens 95-100 17650109-8 2007 However, L-AP4 decreased the levels of cAMP in the presence of forskolin. Colforsin 63-72 replication initiator 1 Rattus norvegicus 11-14 17992606-5 2007 The Sertoli cells isolated from the testes on day 20 were then cultured in the presence or absence of testosterone, FSH, and forskolin, the tPA activities were upregulated by T, FSH and forskolin. Colforsin 125-134 plasminogen activator, tissue type Rattus norvegicus 140-143 17992606-5 2007 The Sertoli cells isolated from the testes on day 20 were then cultured in the presence or absence of testosterone, FSH, and forskolin, the tPA activities were upregulated by T, FSH and forskolin. Colforsin 186-195 plasminogen activator, tissue type Rattus norvegicus 140-143 17323379-2 2007 Sustained exposure to the adenylyl cyclase activator forskolin for 24 h led to a significant increase in mRNA expression of GlnT among different membrane transporters capable of transporting Gln, with an increase in [(3)H]Gln accumulation sensitive to a system A transporter inhibitor, in cultured rat neocortical astrocytes, but not neurons. Colforsin 53-62 solute carrier family 38, member 1 Rattus norvegicus 124-128 17323379-3 2007 Forskolin drastically stimulated GlnT promoter activity in a manner sensitive to a protein kinase A (PKA) inhibitor in rat astrocytic C6 glioma cells, while deletion mutation analysis revealed that the stimulation was mediated by a cAMP responsive element (CRE)/activator protein-1 (AP-1) like site located on GlnT gene promoter. Colforsin 0-9 solute carrier family 38, member 1 Rattus norvegicus 33-37 17323379-3 2007 Forskolin drastically stimulated GlnT promoter activity in a manner sensitive to a protein kinase A (PKA) inhibitor in rat astrocytic C6 glioma cells, while deletion mutation analysis revealed that the stimulation was mediated by a cAMP responsive element (CRE)/activator protein-1 (AP-1) like site located on GlnT gene promoter. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 83-99 17323379-3 2007 Forskolin drastically stimulated GlnT promoter activity in a manner sensitive to a protein kinase A (PKA) inhibitor in rat astrocytic C6 glioma cells, while deletion mutation analysis revealed that the stimulation was mediated by a cAMP responsive element (CRE)/activator protein-1 (AP-1) like site located on GlnT gene promoter. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 101-104 17323379-3 2007 Forskolin drastically stimulated GlnT promoter activity in a manner sensitive to a protein kinase A (PKA) inhibitor in rat astrocytic C6 glioma cells, while deletion mutation analysis revealed that the stimulation was mediated by a cAMP responsive element (CRE)/activator protein-1 (AP-1) like site located on GlnT gene promoter. Colforsin 0-9 solute carrier family 38, member 1 Rattus norvegicus 310-314 17323379-4 2007 Forskolin drastically stimulated the promoter activity in a fashion sensitive to a PKA inhibitor in C6 glioma cells transfected with a CRE or AP-1 reporter plasmid, in association with the phosphorylation of CRE binding protein on serine133. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 83-86 17525299-4 2007 Platelet aggregation by PAR1 or PAR4 was inhibited with similar EC(50) of 1.2 to 2.1 microM forskolin, 31 to 33 microM YC-1, 57 to 150 microM dibutyryl-cAMP, and 220 to 410 microM 8-pCPT-cGMP. Colforsin 92-101 coagulation factor II thrombin receptor Homo sapiens 24-28 17525299-4 2007 Platelet aggregation by PAR1 or PAR4 was inhibited with similar EC(50) of 1.2 to 2.1 microM forskolin, 31 to 33 microM YC-1, 57 to 150 microM dibutyryl-cAMP, and 220 to 410 microM 8-pCPT-cGMP. Colforsin 92-101 F2R like thrombin or trypsin receptor 3 Homo sapiens 32-36 17715681-6 2007 A novel water-soluble forskolin derivative, colforsin daropate hydrochloride (CDH) is a positive inotropic agent for treatment of the heart failure, especially in the severe stage with the beta1 AR desensitization. Colforsin 22-31 adrenoceptor beta 1 Homo sapiens 189-197 17478539-11 2007 In contrast, forskolin (i.e. cAMP elevation)-stimulated NKCC1 activity was sustained, and membrane expression and cell volume remained constant. Colforsin 13-22 solute carrier family 12 member 2 Homo sapiens 56-61 17478539-12 2007 Co-stimulation with forskolin and acetylcholine promoted dramatic recruitment of NKCC1 to basolateral membranes and prolonged the cycle of co-transporter activation, internalization and re-expression. Colforsin 20-29 solute carrier family 12 member 2 Homo sapiens 81-86 17611265-10 2007 Forskolin (which activates cAMP) mimicked the effects of GLP-1 and the PKA inhibitor Rp-8-Bromo-cAMPS (8-bromoadenosine-3",5"-cyclic monophosphorothioate, Rp-isomer) blocked GLP-1 action. Colforsin 0-9 glucagon Mus musculus 57-62 17611265-10 2007 Forskolin (which activates cAMP) mimicked the effects of GLP-1 and the PKA inhibitor Rp-8-Bromo-cAMPS (8-bromoadenosine-3",5"-cyclic monophosphorothioate, Rp-isomer) blocked GLP-1 action. Colforsin 0-9 glucagon Mus musculus 174-179 17373911-7 2007 [(3)H]IP(3) (inositol 1,4,5-trisphosphate) binding affinity and IP(3)-induced Ca2+ release activity were enhanced in permeabilized cells that were pre-treated with forskolin or PKA. Colforsin 164-173 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 177-180 17446183-5 2007 Activators of cAMP and protein kinase C like forskolin and phorbol 12-myristate 3-acetate (PMA), respectively, mimicked GnRH action. Colforsin 45-54 gonadotropin releasing hormone 1 Mus musculus 120-124 17446183-6 2007 Kinetic studies of wild-type ovine FSHBLuc in LbetaT2 cells showed continuous induction by activin (4-fold) over 20 h. Most of this induction (78%) was blocked, beginning at 6 h. cAMP response element binding protein (CREB) was implicated in this inhibition because overexpression of its constitutively active mutant mimicked GnRH, and its inhibitor (inducible cAMP early repressor isoform II) reversed the inhibition caused by GnRH, forskolin, or PMA. Colforsin 434-443 cAMP responsive element binding protein 1 Mus musculus 179-216 17446183-7 2007 In addition, GnRH, forskolin, or PMA increased the expression of a CREB-responsive reporter gene, 6xCRE-37PRL-Luc. Colforsin 19-28 cAMP responsive element binding protein 1 Mus musculus 67-71 17712720-1 2007 The MC2-Receptor (melanocortin 2 receptor, MC2-R) is a Gs-protein coupled receptor that is upregulated by its own ligand ACTH and by forskolin. Colforsin 133-142 melanocortin 2 receptor Homo sapiens 4-16 17712720-1 2007 The MC2-Receptor (melanocortin 2 receptor, MC2-R) is a Gs-protein coupled receptor that is upregulated by its own ligand ACTH and by forskolin. Colforsin 133-142 melanocortin 2 receptor Homo sapiens 18-41 17712720-1 2007 The MC2-Receptor (melanocortin 2 receptor, MC2-R) is a Gs-protein coupled receptor that is upregulated by its own ligand ACTH and by forskolin. Colforsin 133-142 melanocortin 2 receptor Homo sapiens 4-9 17712720-7 2007 However, CREBS133A decreased forskolin stimulated MC2-R promoter activity by 48+/-5% (mean+/-SEM) while unstimulated values remained unchanged. Colforsin 29-38 melanocortin 2 receptor Homo sapiens 50-55 17712720-10 2007 ICER reduced basal luciferase activity in Y1 cells by 17+/-28%, but completely abolished forskolin stimulation. Colforsin 89-98 cAMP responsive element modulator Homo sapiens 0-4 17434817-4 2007 Bovine PTH(1-34) and forskolin markedly increased alkaline phosphatase (ALP) activity and doubled osteocalcin (Oc) expression in early differentiating MC3T3-E1 cells. Colforsin 21-30 bone gamma-carboxyglutamate protein Bos taurus 98-109 17434817-6 2007 Activation of these MAP kinases was detectable after 1 h incubation with 10(-7) M PTH and lasted 1-2 h. Activation of p38 was mimicked by 10 microM forskolin and prevented by H89 suggesting a cAMP-PKA-dependent mechanism of p38 activation. Colforsin 148-157 parathyroid hormone Mus musculus 82-85 17434817-6 2007 Activation of these MAP kinases was detectable after 1 h incubation with 10(-7) M PTH and lasted 1-2 h. Activation of p38 was mimicked by 10 microM forskolin and prevented by H89 suggesting a cAMP-PKA-dependent mechanism of p38 activation. Colforsin 148-157 mitogen-activated protein kinase 14 Mus musculus 118-121 17434817-6 2007 Activation of these MAP kinases was detectable after 1 h incubation with 10(-7) M PTH and lasted 1-2 h. Activation of p38 was mimicked by 10 microM forskolin and prevented by H89 suggesting a cAMP-PKA-dependent mechanism of p38 activation. Colforsin 148-157 mitogen-activated protein kinase 14 Mus musculus 224-227 17482756-8 2007 The MEK inhibitor PD98059 blocked activation by GnRH or forskolin implying that MAPK contributes to cAMP/PKA-mediated activation of follistatin. Colforsin 56-65 midkine Mus musculus 4-7 17519324-3 2007 In fully differentiated luteinizing granulosa cells, follicle-stimulating hormone and forskolin induces expression of ADAMTS-16, suggesting that it is regulated via the cAMP pathway. Colforsin 86-95 ADAM metallopeptidase with thrombospondin type 1 motif 16 Homo sapiens 118-127 17659432-8 2007 Further transient transfection experiments using other cell lines demonstrated that the chicken C/EBPbeta promoter was responsive to forskolin in mouse fibroblasts NIH3T3, but not in human hepatoma HepG2 cells. Colforsin 133-142 CCAAT/enhancer binding protein beta Gallus gallus 96-105 17659432-9 2007 Increase in C/EBPbeta mRNA stability in HD11 cells was induced by forskolin and PMA. Colforsin 66-75 CCAAT/enhancer binding protein beta Gallus gallus 12-21 17659432-10 2007 CONCLUSION: The results indicate that the C/EBPbeta gene is regulated transcriptionally as well as post-transcriptionally in response to forskolin and PMA, and the forskolin responsiveness of the C/EBPbeta promoter seems to depend on cellular cAMP turnover. Colforsin 137-146 CCAAT/enhancer binding protein beta Gallus gallus 42-51 17659432-10 2007 CONCLUSION: The results indicate that the C/EBPbeta gene is regulated transcriptionally as well as post-transcriptionally in response to forskolin and PMA, and the forskolin responsiveness of the C/EBPbeta promoter seems to depend on cellular cAMP turnover. Colforsin 164-173 CCAAT/enhancer binding protein beta Gallus gallus 42-51 17659432-10 2007 CONCLUSION: The results indicate that the C/EBPbeta gene is regulated transcriptionally as well as post-transcriptionally in response to forskolin and PMA, and the forskolin responsiveness of the C/EBPbeta promoter seems to depend on cellular cAMP turnover. Colforsin 164-173 CCAAT/enhancer binding protein beta Gallus gallus 196-205 17347851-6 2007 In pdzk1 -/- jejunal mucosa, basal net Na(+) absorption as well as the inhibition of Na(+) absorption by forskolin was significantly reduced. Colforsin 105-114 PDZ domain containing 1 Mus musculus 3-8 17347851-7 2007 In pdzk1 -/- duodenal mucosa, identical basal I (SC) and (J(HCO-)(3)) but a significant, yet mild, reduction of forskolin-stimulated Delta(J(HCO-)(3)) and DeltaI (SC) was observed compared to +/+ tissue. Colforsin 112-121 PDZ domain containing 1 Mus musculus 3-8 17596451-5 2007 However, in the presence of forskolin or cocaine, the facilitation of the dopamine IPSC was significantly reduced in Lep(ob/ob) mice. Colforsin 28-37 leptin Mus musculus 117-120 17717854-0 2007 Forskolin and 8-cyclopentyltheophyline synergistically facilitate the neuronal activity in the CA2 area of rat hippocampus via caMP and non-caMP cascades. Colforsin 0-9 carbonic anhydrase 2 Rattus norvegicus 95-98 17395628-5 2007 In pdzk1-/- colonic surface cells, acid-activated NHE3 transport rates were strongly reduced, and the inhibitory effect of forskolin and ionomcyin was virtually abolished. Colforsin 123-132 PDZ domain containing 1 Mus musculus 3-8 17482756-8 2007 The MEK inhibitor PD98059 blocked activation by GnRH or forskolin implying that MAPK contributes to cAMP/PKA-mediated activation of follistatin. Colforsin 56-65 cathelicidin antimicrobial peptide Mus musculus 100-104 17383824-4 2007 NPY also inhibited osteoclastogenesis induced by forskolin, an activator of adenylate cyclase; however, it did not inhibit that induced by exogenously supplied dibutyryl cAMP, a cell-permeable cAMP analog that activates cAMP-dependent protein kinase. Colforsin 49-58 neuropeptide Y Mus musculus 0-3 17412691-6 2007 This nuclear export of Id1 was inhibited by protein kinase A (PKA) activation by dibutyryl cyclic AMP and forskolin but was promoted by PKA inactivation by H-89 and MDL-12,330A. Colforsin 106-115 inhibitor of DNA binding 1, HLH protein Homo sapiens 23-26 17277021-5 2007 Activation of PKA (dibutyryl-cAMP, forskolin) or PKG (dibutyryl-cGMP, sodium nitroprusside, nitric oxide) similarly abolished the ability of UTP to suppress K(DR) and did so without effect on baseline current. Colforsin 35-44 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 14-17 17277048-7 2007 TNF-alpha caused a significant dose- (1-10 ng/ml) and time-dependent (24 and 48 h) increase in forskolin-stimulated adenylyl cyclase activity, which was abrogated by pretreatment with GW5074 (a raf-1 kinase inhibitor), was partially inhibited by an EGF receptor inhibitor, but was unaffected by pertussis toxin. Colforsin 95-104 tumor necrosis factor Homo sapiens 0-9 17277048-7 2007 TNF-alpha caused a significant dose- (1-10 ng/ml) and time-dependent (24 and 48 h) increase in forskolin-stimulated adenylyl cyclase activity, which was abrogated by pretreatment with GW5074 (a raf-1 kinase inhibitor), was partially inhibited by an EGF receptor inhibitor, but was unaffected by pertussis toxin. Colforsin 95-104 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 194-199 17320350-7 2007 We found that cAMP/PKA/CREB pathway is indeed an important regulator of Smac/DIABLO transcription, since exposure to the cAMP analog 8-CPT-cAMP, the adenylyl cyclase activator forskolin, the inhibitor of phosphodiesterase isobutylmethylxanthine or by hindering PKA activation with H89, regulated the promoter activity, as shown by gene reporter and RT-PCR assays. Colforsin 176-185 cathelicidin antimicrobial peptide Homo sapiens 14-18 17272923-4 2007 When treated with the decidual stimulus dibutyryl-cAMP (db-cAMP) or forskolin, the fibroblastic cell-shaped EtsT cells transformed into large- and round-shaped cells and secreted large amounts of the decidual markers prolactin (PRL) and insulin-like growth factor binding protein-1 (IGFBP-1). Colforsin 68-77 prolactin Homo sapiens 228-231 17320350-7 2007 We found that cAMP/PKA/CREB pathway is indeed an important regulator of Smac/DIABLO transcription, since exposure to the cAMP analog 8-CPT-cAMP, the adenylyl cyclase activator forskolin, the inhibitor of phosphodiesterase isobutylmethylxanthine or by hindering PKA activation with H89, regulated the promoter activity, as shown by gene reporter and RT-PCR assays. Colforsin 176-185 cAMP responsive element binding protein 1 Homo sapiens 23-27 17320350-7 2007 We found that cAMP/PKA/CREB pathway is indeed an important regulator of Smac/DIABLO transcription, since exposure to the cAMP analog 8-CPT-cAMP, the adenylyl cyclase activator forskolin, the inhibitor of phosphodiesterase isobutylmethylxanthine or by hindering PKA activation with H89, regulated the promoter activity, as shown by gene reporter and RT-PCR assays. Colforsin 176-185 diablo IAP-binding mitochondrial protein Homo sapiens 72-76 17320350-7 2007 We found that cAMP/PKA/CREB pathway is indeed an important regulator of Smac/DIABLO transcription, since exposure to the cAMP analog 8-CPT-cAMP, the adenylyl cyclase activator forskolin, the inhibitor of phosphodiesterase isobutylmethylxanthine or by hindering PKA activation with H89, regulated the promoter activity, as shown by gene reporter and RT-PCR assays. Colforsin 176-185 diablo IAP-binding mitochondrial protein Homo sapiens 77-83 17320350-7 2007 We found that cAMP/PKA/CREB pathway is indeed an important regulator of Smac/DIABLO transcription, since exposure to the cAMP analog 8-CPT-cAMP, the adenylyl cyclase activator forskolin, the inhibitor of phosphodiesterase isobutylmethylxanthine or by hindering PKA activation with H89, regulated the promoter activity, as shown by gene reporter and RT-PCR assays. Colforsin 176-185 cathelicidin antimicrobial peptide Homo sapiens 121-125 17320350-7 2007 We found that cAMP/PKA/CREB pathway is indeed an important regulator of Smac/DIABLO transcription, since exposure to the cAMP analog 8-CPT-cAMP, the adenylyl cyclase activator forskolin, the inhibitor of phosphodiesterase isobutylmethylxanthine or by hindering PKA activation with H89, regulated the promoter activity, as shown by gene reporter and RT-PCR assays. Colforsin 176-185 cathelicidin antimicrobial peptide Homo sapiens 121-125 17324955-7 2007 Forskolin-induced AC activation and downstream signaling, such as the synthesis of cAMP and the phosphorylation of transcriptional factor CRE-binding protein were upregulated in the GnT-III transfectants compared with mock transfectants or a dominant negative mutant of GnT-III-transfected cells. Colforsin 0-9 mannoside acetylglucosaminyltransferase 3 Mus musculus 182-189 17324955-7 2007 Forskolin-induced AC activation and downstream signaling, such as the synthesis of cAMP and the phosphorylation of transcriptional factor CRE-binding protein were upregulated in the GnT-III transfectants compared with mock transfectants or a dominant negative mutant of GnT-III-transfected cells. Colforsin 0-9 mannoside acetylglucosaminyltransferase 3 Mus musculus 270-277 17545604-4 2007 Low-dose forskolin causes KM12C cells to exit the cell cycle in G1 by inducing p27(Kip1) and primes cells for apoptosis on addition of rolipram. Colforsin 9-18 interferon alpha inducible protein 27 Homo sapiens 79-82 17545604-4 2007 Low-dose forskolin causes KM12C cells to exit the cell cycle in G1 by inducing p27(Kip1) and primes cells for apoptosis on addition of rolipram. Colforsin 9-18 cyclin dependent kinase inhibitor 1B Homo sapiens 83-87 17545604-5 2007 The effect of the low-dose forskolin/rolipram combination is mediated by displacement of the phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide 3-kinase signaling module from the plasma membrane and suppression of the Akt/protein kinase-B oncogene pathway, to which KM12C cells are addicted for growth. Colforsin 27-36 protein tyrosine kinase 2 beta Homo sapiens 229-245 17426037-7 2007 Expression of a constitutively active CREBVP16 construct, or exposure to forskolin to induce CREB phosphorylation, rescued ATM negative cells and restored differentiation. Colforsin 73-82 ATM serine/threonine kinase Homo sapiens 123-126 17221218-6 2007 Furthermore, the cytochrome P450scc enzyme was expressed in human keratinocytes and was induced by forskolin, a known activator of steroidogenesis, and forskolin also upregulated CCHCR1. Colforsin 99-108 coiled-coil alpha-helical rod protein 1 Homo sapiens 179-185 17221218-6 2007 Furthermore, the cytochrome P450scc enzyme was expressed in human keratinocytes and was induced by forskolin, a known activator of steroidogenesis, and forskolin also upregulated CCHCR1. Colforsin 152-161 coiled-coil alpha-helical rod protein 1 Homo sapiens 179-185 17272923-4 2007 When treated with the decidual stimulus dibutyryl-cAMP (db-cAMP) or forskolin, the fibroblastic cell-shaped EtsT cells transformed into large- and round-shaped cells and secreted large amounts of the decidual markers prolactin (PRL) and insulin-like growth factor binding protein-1 (IGFBP-1). Colforsin 68-77 insulin like growth factor binding protein 1 Homo sapiens 237-281 17272923-4 2007 When treated with the decidual stimulus dibutyryl-cAMP (db-cAMP) or forskolin, the fibroblastic cell-shaped EtsT cells transformed into large- and round-shaped cells and secreted large amounts of the decidual markers prolactin (PRL) and insulin-like growth factor binding protein-1 (IGFBP-1). Colforsin 68-77 insulin like growth factor binding protein 1 Homo sapiens 283-290 17272923-5 2007 Analysis of the stathmin protein levels in the db-cAMP- and forskolin-treated EtsT cells revealed that the total and phosphorylated protein levels dropped as decidualization progressed. Colforsin 60-69 stathmin 1 Homo sapiens 16-24 17499748-4 2007 Immunocytochemical staining showed that granulosa cells expressed EGF and its receptor, and their expression was increased by PGE(1) (1-100 ng/ml) or forskolin (10(-7) to 10(-5)M) treatments. Colforsin 150-159 epidermal growth factor Gallus gallus 66-69 17428469-2 2007 As TRPV1 is sensitized also by protein kinase A (PKA)-mediated phosphorylation, we investigated the effect of two activators of the PKA pathway, 8-Br-cAMP and forskolin, on the activity of menthol and icilin at TRPM8 in HEK-293 cells stably overexpressing the channel (TRPM8-HEK-293 cells). Colforsin 159-168 transient receptor potential cation channel subfamily V member 1 Homo sapiens 3-8 17395587-6 2007 The induction of IL-6 by salmeterol was dependent upon the beta(2) receptor and could also be induced by cAMP or cAMP-elevating agents forskolin and rolipram. Colforsin 135-144 interleukin 6 Homo sapiens 17-21 17521429-7 2007 Differential V2 receptor or G-protein activity was not involved since CD ET-1 KO IMCD had increased cAMP accumulation in response to forskolin and/or cholera toxin. Colforsin 133-142 endothelin 1 Mus musculus 73-77 17416458-0 2007 Activation of protein kinase Czeta mediates luteinizing hormone- or forskolin-induced NGFI-B expression in preovulatory granulosa cells of rat ovary. Colforsin 68-77 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 86-92 17416458-2 2007 In this report, we investigated the signaling pathway for LH- and forskolin-induced NGFI-B expression in cultured rat granulosa cells of preovulatory follicles. Colforsin 66-75 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 84-90 17416458-3 2007 LH- or forskolin-induced NGFI-B expression was suppressed by high dose of protein kinase C (PKC) inhibitor RO 31-8220 (10 microM), but not by low doses RO 31-8220 (0.1-1.0 microM) or adenylate cyclase inhibitor MDL-12,300A, implicating the involvement of atypical PKCs. Colforsin 7-16 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 25-31 17416458-6 2007 Treatment with the cell-permeable PKCzeta-specific inhibitor pseudosubstrate peptide inhibited LH-or forskolin-induced NGFI-B expression, indicating the essential role of PKCzeta. Colforsin 101-110 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 119-125 17416458-7 2007 Consistent with this promise, in granulosa cells depleted of diacylglycerol sensitive PKCs by prolonged treatment with tetradecanoylphobol-13-acetate, LH or forskolin could still induce NGFI-B expression, and RO 31-8220 or the PKCzeta pseudosubstrate peptide inhibited LH- or forskolin-induced NGFI-B expression. Colforsin 157-166 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 186-192 17416458-7 2007 Consistent with this promise, in granulosa cells depleted of diacylglycerol sensitive PKCs by prolonged treatment with tetradecanoylphobol-13-acetate, LH or forskolin could still induce NGFI-B expression, and RO 31-8220 or the PKCzeta pseudosubstrate peptide inhibited LH- or forskolin-induced NGFI-B expression. Colforsin 157-166 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 294-300 17416458-8 2007 Furthermore, overexpression of dominant-negative PKCzeta in primary granulosa cells using a replication-defective adenovirus vector resulted in the suppression of LH- or forskolin-induced NGFI-B expression. Colforsin 170-179 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 188-194 17416458-9 2007 Our findings demonstrate that PKCzeta, which is activated by LH or forskolin, contributes to the induction of NGFI-B in granulosa cells of preovulatory follicles. Colforsin 67-76 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 110-116 17428796-8 2007 In lung fibroblasts, inhibition of the TGFbeta1-stimulated CCN2/CTGF by PGE(2), butaprost, or forskolin is due to p38, ERK, and JNK MAP kinase inhibition that is cAMP-dependent. Colforsin 94-103 transforming growth factor beta 1 Homo sapiens 39-47 17428796-8 2007 In lung fibroblasts, inhibition of the TGFbeta1-stimulated CCN2/CTGF by PGE(2), butaprost, or forskolin is due to p38, ERK, and JNK MAP kinase inhibition that is cAMP-dependent. Colforsin 94-103 cellular communication network factor 2 Homo sapiens 59-63 17428796-8 2007 In lung fibroblasts, inhibition of the TGFbeta1-stimulated CCN2/CTGF by PGE(2), butaprost, or forskolin is due to p38, ERK, and JNK MAP kinase inhibition that is cAMP-dependent. Colforsin 94-103 cellular communication network factor 2 Homo sapiens 64-68 17428796-8 2007 In lung fibroblasts, inhibition of the TGFbeta1-stimulated CCN2/CTGF by PGE(2), butaprost, or forskolin is due to p38, ERK, and JNK MAP kinase inhibition that is cAMP-dependent. Colforsin 94-103 mitogen-activated protein kinase 14 Homo sapiens 114-117 17428796-8 2007 In lung fibroblasts, inhibition of the TGFbeta1-stimulated CCN2/CTGF by PGE(2), butaprost, or forskolin is due to p38, ERK, and JNK MAP kinase inhibition that is cAMP-dependent. Colforsin 94-103 mitogen-activated protein kinase 8 Homo sapiens 128-131 17428796-12 2007 Whereas forskolin reduces TGFbeta1-stimulated expression of CCN2/CTGF by 35% and JNK activation in gingival fibroblasts, micromolar PGE(2)-stimulated JNK in gingival fibroblasts and opposes the inhibitory effects of cAMP on CCN2/CTGF expression. Colforsin 8-17 transforming growth factor beta 1 Homo sapiens 26-34 17428796-12 2007 Whereas forskolin reduces TGFbeta1-stimulated expression of CCN2/CTGF by 35% and JNK activation in gingival fibroblasts, micromolar PGE(2)-stimulated JNK in gingival fibroblasts and opposes the inhibitory effects of cAMP on CCN2/CTGF expression. Colforsin 8-17 cellular communication network factor 2 Homo sapiens 60-64 17428796-12 2007 Whereas forskolin reduces TGFbeta1-stimulated expression of CCN2/CTGF by 35% and JNK activation in gingival fibroblasts, micromolar PGE(2)-stimulated JNK in gingival fibroblasts and opposes the inhibitory effects of cAMP on CCN2/CTGF expression. Colforsin 8-17 cellular communication network factor 2 Homo sapiens 65-69 17462633-4 2007 In BON1 cells, the somatostatin-induced inhibition of forskolin-induced secretion of chromogranin A is not blocked by Y-27632. Colforsin 54-63 somatostatin Homo sapiens 19-31 17462633-4 2007 In BON1 cells, the somatostatin-induced inhibition of forskolin-induced secretion of chromogranin A is not blocked by Y-27632. Colforsin 54-63 chromogranin A Homo sapiens 85-99 17462633-5 2007 It is therefore concluded that the inhibitory effect of somatostatin in forskolin-stimulated cells is not dependent on cell contraction. Colforsin 72-81 somatostatin Homo sapiens 56-68 17428469-4 2007 Both 8-Br-cAMP (100 microM) and forskolin (10 microM) right-shifted the dose-response curves for the TRPM8-mediated effect of icilin and menthol on intracellular Ca(2+). Colforsin 32-41 transient receptor potential cation channel subfamily M member 8 Homo sapiens 101-106 17428235-4 2007 In our hands, adenosine and forskolin stimulated calcium release from IP(3) controlled stores in HEK-GHSR cells but not in non-transfected HEK cells. Colforsin 28-37 growth hormone secretagogue receptor Homo sapiens 101-105 17234961-9 2007 In contrast, increasing concentrations of forskolin (a direct stimulant of adenylate cyclase) and dibutyryl cAMP (a metabolically active membrane-soluble analog of cAMP) completely reversed TNF-alpha-mediated depression, though only in the presence of NMA. Colforsin 42-51 tumor necrosis factor Rattus norvegicus 190-199 17237149-6 2007 Cells injected with DeltaF508-CFTR alone presented a low chloride channel activity, whereas its coexpression with NHE-RF1 significantly increased both the basal and forskolin-activated chloride conductances. Colforsin 165-174 CF transmembrane conductance regulator Canis lupus familiaris 30-34 17237149-6 2007 Cells injected with DeltaF508-CFTR alone presented a low chloride channel activity, whereas its coexpression with NHE-RF1 significantly increased both the basal and forskolin-activated chloride conductances. Colforsin 165-174 SLC9A3 regulator 1 Canis lupus familiaris 114-121 17265067-0 2007 Rho-family small GTPases are involved in forskolin-induced cell-cell contact formation of renal glomerular podocytes in vitro. Colforsin 41-50 ras homolog family member A Mus musculus 0-24 17469134-5 2007 In these cultures, cAMP levels were augmented by treatment with either forskolin (4, 16, or 64 microM) or 3-isobutyl-1-methyl xanthine (IBMX; 4, 16, or 64 microM). Colforsin 71-80 cathelicidin-7 Bos taurus 19-23 17469134-10 2007 OSM and TNF induced a 6-fold increase in (342)FFGV-G2, which was abrogated by forskolin and IBMX (by >80%). Colforsin 78-87 tumor necrosis factor Bos taurus 8-11 17469134-11 2007 OSM and TNF stimulated MMP expression as visualized by zymography, and MMP expression was dose-dependently inhibited by forskolin and IBMX. Colforsin 120-129 tumor necrosis factor Bos taurus 8-11 17265067-5 2007 The activity of the Rho-family small GTPases before and after forskolin treatment has been evaluated with a glutathione-S-transferase pull-down assay. Colforsin 62-71 ras homolog family member A Mus musculus 20-44 17376427-4 2007 Increasing PKA levels in chick limb development using Forskolin had no effect on posterior polarizing activity but weak polarizing activity, based on ligand-independent Shh signaling, was induced in anterior limb bud cells resulting in extra digits. Colforsin 54-63 Protein kinase, cAMP-dependent, regulatory subunit type 1 Drosophila melanogaster 11-14 17376427-5 2007 Manipulating PKA activity levels directly with a retrovirus expressing activated PKA induced extra digits similar to those induced by Forskolin treatment suggesting that PKA may have a previously unrecognized positive role in Shh signaling in vertebrate limbs. Colforsin 134-143 sonic hedgehog Gallus gallus 226-229 17325033-5 2007 Induction of CREB phosphorylation with forskolin or 6bnz-cAMP mimics TGFbeta"s inhibitory effect on cyclin A expression. Colforsin 39-48 cAMP responsive element binding protein 1 Homo sapiens 13-17 17289845-7 2007 Mutagenesis of the CRE or overexpression of a dominant-negative CREB reduced forskolin-induced promoter activation. Colforsin 77-86 cAMP responsive element binding protein 1 Homo sapiens 64-68 17325033-5 2007 Induction of CREB phosphorylation with forskolin or 6bnz-cAMP mimics TGFbeta"s inhibitory effect on cyclin A expression. Colforsin 39-48 transforming growth factor beta 1 Homo sapiens 69-76 17325033-5 2007 Induction of CREB phosphorylation with forskolin or 6bnz-cAMP mimics TGFbeta"s inhibitory effect on cyclin A expression. Colforsin 39-48 cyclin A2 Homo sapiens 100-108 17331469-5 2007 We show that VCP is dispensable for CT retrotranslocation, however RNAi of either Ufd1 or Npl4 induces an increase in adenylyl cyclase activity induced by CT. RNAi of VCP, Ufd1 or Npl4 did not affect adenylyl cyclase activity induced by forskolin. Colforsin 237-246 ubiquitin recognition factor in ER associated degradation 1 Homo sapiens 82-86 17306238-10 2007 Furthermore, forskolin"s protective effect was substantially reduced in CGN cultures genetically deficient for nNOS (from nNOS-/- mice). Colforsin 13-22 nitric oxide synthase 1, neuronal Mus musculus 111-115 17306238-10 2007 Furthermore, forskolin"s protective effect was substantially reduced in CGN cultures genetically deficient for nNOS (from nNOS-/- mice). Colforsin 13-22 nitric oxide synthase 1, neuronal Mus musculus 122-134 17616730-7 2007 Arachidonic acid was shown by immunoblotting to prevent induction of cyclooxygenase-2 by PGE(2), forskolin or dibutyryl cAMP. Colforsin 97-106 prostaglandin-endoperoxide synthase 2 Bos taurus 69-85 17306238-8 2007 Forskolin, an activator of the cAMP pathway, stimulated expression of a reporter gene under the control of the nNOS promoter, and this stimulation was substantially reduced when the two CREs were mutated. Colforsin 0-9 nitric oxide synthase 1, neuronal Mus musculus 111-115 17306238-9 2007 Forskolin increased nNOS mRNA levels several fold, increased production of nitric oxide, and abolished alcohol"s toxic effect in wild type CGN. Colforsin 0-9 nitric oxide synthase 1, neuronal Mus musculus 20-24 17331469-5 2007 We show that VCP is dispensable for CT retrotranslocation, however RNAi of either Ufd1 or Npl4 induces an increase in adenylyl cyclase activity induced by CT. RNAi of VCP, Ufd1 or Npl4 did not affect adenylyl cyclase activity induced by forskolin. Colforsin 237-246 NPL4 homolog, ubiquitin recognition factor Homo sapiens 90-94 17218421-8 2007 Wild-type and osteonectin-null osteoblasts generated comparable amounts of cAMP in response to forskolin, a direct stimulator of adenylyl cyclase. Colforsin 95-104 secreted acidic cysteine rich glycoprotein Mus musculus 14-25 17417610-0 2007 Inhibition by brimonidine of forskolin-induced nitric oxide synthase expression in human ciliary bodies in vitro. Colforsin 29-38 nitric oxide synthase 1 Homo sapiens 47-68 17417610-6 2007 Forskolin significantly up-regulated the mRNA and protein expression of nNOS, but not that of iNOS or of eNOS. Colforsin 0-9 nitric oxide synthase 1 Homo sapiens 72-76 17417610-7 2007 In the presence of brimonidine, the forskolin-induced up-regulation of nNOS mRNA or protein expression was significantly inhibited. Colforsin 36-45 nitric oxide synthase 1 Homo sapiens 71-75 17417610-8 2007 CONCLUSIONS: In human ciliary body (where aqueous humor is produced), brimonidine inhibits the up-regulation of nNOS expression induced by forskolin. Colforsin 139-148 nitric oxide synthase 1 Homo sapiens 112-116 17190904-7 2007 The stimulatory action of GLP-1 is cAMP dependent, being reproduced by the adenylate cyclase activator forskolin and the cAMP analog N(6)-benzoyladenosine-3",5"-cAMP and inhibited by a PKA inhibitor. Colforsin 103-112 glucagon Rattus norvegicus 26-31 17272757-4 2007 In human coronary arterial endothelial cells, 8-bromo-cAMP, the adenylate cyclase activator forskolin, or a cAMP-dependent protein kinase (PKA) activator effectively decreased BMP-4 expression, mimicking the effects of shear stress. Colforsin 92-101 bone morphogenetic protein 4 Homo sapiens 176-181 17272757-5 2007 Indeed, shear stress induced the nuclear translocation of PKA-c, and inhibition of PKA attenuated the effects of shear stress and forskolin on BMP-4 expression. Colforsin 130-139 bone morphogenetic protein 4 Homo sapiens 143-148 17218408-9 2007 The PMSG-dependent increase in Pde3 activity and Pde3a mRNA were mimicked by the adenylyl cyclase activator forskolin or prostaglandin E2. Colforsin 108-117 phosphodiesterase 3A Homo sapiens 49-54 17182731-7 2007 Injection of N1303K (class II trafficking mutation) yielded low levels of CFTR function on activation with forskolin and 3-isobutyl-1-methylxanthine (IBMX). Colforsin 107-116 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 74-78 17079782-6 2007 Forskolin stably elevated the NPPB-sensitive Isc associated with an increase in the NPPB-sensitive Gt in PSM and NP. Colforsin 0-9 natriuretic peptide B Homo sapiens 30-34 17079782-6 2007 Forskolin stably elevated the NPPB-sensitive Isc associated with an increase in the NPPB-sensitive Gt in PSM and NP. Colforsin 0-9 natriuretic peptide B Homo sapiens 84-88 17194743-5 2007 Moreover, CB1-/--derived pituitary cells respond with a significantly higher ACTH secretion to CRH and forskolin challenges as compared with pituitary cells derived from CB1+/+ mice. Colforsin 103-112 cannabinoid receptor 1 (brain) Mus musculus 10-13 17275084-3 2007 Using a BeWo cell model, we explored the role of the xenobiotic/lipid transporter ABCG2 in promoting cell survival during forskolin-induced differentiation. Colforsin 122-131 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 82-87 17244698-8 2007 Cotransfection of cells with a plasmid encoding the dominant-negative CRE binding protein (CREB) completely abolished the inducibility of the reporter gene activity by forskolin. Colforsin 168-177 cAMP responsive element binding protein 1 Mus musculus 70-89 17244698-8 2007 Cotransfection of cells with a plasmid encoding the dominant-negative CRE binding protein (CREB) completely abolished the inducibility of the reporter gene activity by forskolin. Colforsin 168-177 cAMP responsive element binding protein 1 Mus musculus 91-95 17389480-12 2007 NECA (a potent A2B agonist) and forskolin, agents known to elevate cAMP in bovine corneal endothelial cells, also suppressed the effect of thrombin. Colforsin 32-41 coagulation factor II, thrombin Bos taurus 139-147 17204749-5 2007 Functionally, LY404039 potently inhibited forskolin-stimulated cAMP formation in cells expressing human mGlu2 and mGlu3 receptors. Colforsin 42-51 glutamate receptor, metabotropic 3 Mus musculus 114-119 17277356-6 2007 Binding sites predicted in 6 genes were confirmed by CREB chromatin immunoprecipitation and forskolin induction of CBP binding. Colforsin 92-101 cAMP responsive element binding protein 1 Mus musculus 53-57 17484286-0 2007 Effect of forskolin on the expression of claudin-5 in human trophoblast BeWo cells. Colforsin 10-19 claudin 5 Homo sapiens 41-50 17484286-5 2007 Forskolin, which induces the differentiation of BeWo cells from cytotrophoblast-like cells into syncytiotrophoblast-like cells, reduced slightly the expression of claudin-5. Colforsin 0-9 claudin 5 Homo sapiens 163-172 17484286-6 2007 This is the first report to show changes in claudin-5 in forskolin-treated BeWo cells. Colforsin 57-66 claudin 5 Homo sapiens 44-53 17636236-7 2007 In primary amnion epithelial cell culture, AQP1 mRNA expression increased significantly at 10 hours (0.219 +/- 0.006 to 0.314 +/- 0.008, P < .05) and remained elevated for 20 hours (0.223 +/- 0.004 to 0.323 +/- 0.012, P < .05) following forskolin treatment. Colforsin 243-252 aquaporin 1 (Colton blood group) Homo sapiens 43-47 17636236-8 2007 AQP8 mRNA expression increased significantly at 2 hours (0.069 +/- 0.003 to 0.086 +/- 0.012, P < .05) and remained upregulated for 20 hours following forskolin treatment. Colforsin 153-162 aquaporin 8 Homo sapiens 0-4 17636236-9 2007 Forskolin stimulation of AQP9 mRNA expression was evidenced by 10 hours (0.098 +/- 0.005 to 0.115 +/- 0.006, P < .05) and maintained for 20 hours. Colforsin 0-9 aquaporin 9 Homo sapiens 25-29 17636236-11 2007 Human amnion epithelial cell AQP1, 8, and 9 mRNA expression is upregulated by cAMP as their expression is simulated by forskolin. Colforsin 119-128 aquaporin 1 (Colton blood group) Homo sapiens 29-43 17277356-6 2007 Binding sites predicted in 6 genes were confirmed by CREB chromatin immunoprecipitation and forskolin induction of CBP binding. Colforsin 92-101 CREB binding protein Mus musculus 115-118 17277356-7 2007 Moreover, CREB siRNA substantially blocked induction of 5 genes by forskolin and of 3 genes following inhibition of GSK-3. Colforsin 67-76 cAMP responsive element binding protein 1 Mus musculus 10-14 17196958-8 2007 It was concluded that the inhibition of phosphodiesterase is a probable mechanism for the effect of nifedipine and verapamil on CRH or forskolin induction of proopiomelanocortin gene expression. Colforsin 135-144 proopiomelanocortin Rattus norvegicus 158-177 17391526-11 2007 Forskolin, which activates the cAMP pathway, and rapamycin, which inhibits mTOR, also inhibit JNK. Colforsin 0-9 mitogen-activated protein kinase 8 Homo sapiens 94-97 17196958-3 2007 Mouse pituitary tumor cells stably transfected with approximately 0.7 kb of the rat proopiomelanocortin 5" promoter-luciferase fusion gene were stimulated by potassium chloride, corticotropin-releasing hormone (CRH) or forskolin, in the presence or absence of calcium channel blockers (nifedipine, verapamil and diltiazem). Colforsin 219-228 proopiomelanocortin Rattus norvegicus 84-103 17395978-10 2007 SRIF and pasireotide completely blocked forskolin-induced VEGF secretion. Colforsin 40-49 vascular endothelial growth factor A Homo sapiens 58-62 17196958-5 2007 A dose-dependent enhancement of CRH- or forskolin-stimulated proopiomelanocortin promoter activity was observed with nifedipine and verapamil, but not diltiazem. Colforsin 40-49 proopiomelanocortin Rattus norvegicus 61-80 17095754-4 2007 Although blocking the presumably apically located K(+) channel KCNQ1 with chromanol 293b reduced both the forskolin- and carbachol-induced cell shrinkage, inhibition of Ca(2+)-sensitive K(+) channels with charybdotoxin strongly inhibited the cell volume decrease after carbachol, but not after forskolin stimulation. Colforsin 106-115 potassium voltage-gated channel subfamily KQT member 1 Oryctolagus cuniculus 63-68 17095754-4 2007 Although blocking the presumably apically located K(+) channel KCNQ1 with chromanol 293b reduced both the forskolin- and carbachol-induced cell shrinkage, inhibition of Ca(2+)-sensitive K(+) channels with charybdotoxin strongly inhibited the cell volume decrease after carbachol, but not after forskolin stimulation. Colforsin 294-303 potassium voltage-gated channel subfamily KQT member 1 Oryctolagus cuniculus 63-68 17206499-7 2007 Forskolin induced translocation of AQP2 from the subapical storage vesicles to the apical plasma membrane, which did not affect GLUT4 localization. Colforsin 0-9 aquaporin 2 Canis lupus familiaris 35-39 17097801-8 2007 This effect was enhanced when cAMP levels were increased by forskolin (the maximal effect was 53.0+/-5.1 vs. 83.1+/-5.7%, p<0.01) or in strips with urothelium. Colforsin 60-69 cathelicidin antimicrobial peptide Homo sapiens 30-34 17206499-8 2007 When forskolin was washed out, AQP2 was first retrieved to early endosomes from the apical plasma membrane, where it was partly colocalized with GLUT4. Colforsin 5-14 aquaporin 2 Canis lupus familiaris 31-35 17206499-8 2007 When forskolin was washed out, AQP2 was first retrieved to early endosomes from the apical plasma membrane, where it was partly colocalized with GLUT4. Colforsin 5-14 solute carrier family 2 member 4 Canis lupus familiaris 145-150 17158221-5 2007 Stimulation of cAMP production with forskolin/3-isobutyl-1-methylxanthine (50 microM) or dibutyryl-cAMP (1 mM) caused a significant rightward shift in the midpoint activation potential of beta-Ih, whereas expression of either specific small interfering (si)RNA against HCN2 (siHCN2b) or a dominant-negative HCN channel (HCN1-AAA) caused a near-complete inhibition of time-dependent beta-Ih. Colforsin 36-45 hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Mus musculus 269-273 17152074-0 2007 Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter. Colforsin 43-52 AKT serine/threonine kinase 1 Homo sapiens 16-20 17152074-0 2007 Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter. Colforsin 43-52 cAMP responsive element binding protein 1 Homo sapiens 109-113 17152074-0 2007 Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter. Colforsin 43-52 AKT serine/threonine kinase 1 Homo sapiens 141-145 17152074-1 2007 Recently, we reported that silencing CREB gene expression by RNAi significantly attenuates forskolin-induced activation of Akt1. Colforsin 91-100 cAMP responsive element binding protein 1 Homo sapiens 37-41 17152074-1 2007 Recently, we reported that silencing CREB gene expression by RNAi significantly attenuates forskolin-induced activation of Akt1. Colforsin 91-100 AKT serine/threonine kinase 1 Homo sapiens 123-127 17152074-2 2007 We now provide evidence that forskolin-treatment causes transcriptional and translational upregulation of Akt1 in macrophages. Colforsin 29-38 AKT serine/threonine kinase 1 Homo sapiens 106-110 17152074-4 2007 Akt protein levels increased by approximately 1.5-fold after only a 5 min exposure of macrophages to forskolin. Colforsin 101-110 AKT serine/threonine kinase 1 Homo sapiens 0-3 17152074-6 2007 Maximal upregulation of Akt1 occurred in cells treated with 10 microM forskolin. Colforsin 70-79 AKT serine/threonine kinase 1 Homo sapiens 24-28 17152074-7 2007 Forskolin-dependent Akt1 synthesis was abolished by pretreating the cells with CREB-directed dsRNA as demonstrated at both the message and protein level, as well as by determining the synthesis of [(35)S]-labeled Akt1 protein. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 20-24 17152074-7 2007 Forskolin-dependent Akt1 synthesis was abolished by pretreating the cells with CREB-directed dsRNA as demonstrated at both the message and protein level, as well as by determining the synthesis of [(35)S]-labeled Akt1 protein. Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 79-83 17152074-7 2007 Forskolin-dependent Akt1 synthesis was abolished by pretreating the cells with CREB-directed dsRNA as demonstrated at both the message and protein level, as well as by determining the synthesis of [(35)S]-labeled Akt1 protein. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 213-217 17152074-8 2007 The PKA inhibitor H-89, greatly attenuated forskolin-induced Akt1 synthesis. Colforsin 43-52 AKT serine/threonine kinase 1 Homo sapiens 61-65 17152074-9 2007 Transcriptional and translational inhibitors also greatly reduced Akt1 synthesis in forskolin-stimulated [(14)C]leucine-labeled macrophages. Colforsin 84-93 AKT serine/threonine kinase 1 Homo sapiens 66-70 17152074-11 2007 In conclusion, we show here for the first time transcriptional upregulation of Akt1 by CREB, based upon Akt1 protein synthesis and its modulation by transitional and translational inhibitors in forskolin-stimulated cells, Akt1 protein. Colforsin 194-203 AKT serine/threonine kinase 1 Homo sapiens 79-83 17152074-11 2007 In conclusion, we show here for the first time transcriptional upregulation of Akt1 by CREB, based upon Akt1 protein synthesis and its modulation by transitional and translational inhibitors in forskolin-stimulated cells, Akt1 protein. Colforsin 194-203 cAMP responsive element binding protein 1 Homo sapiens 87-91 17279541-4 2007 N-methyl-D-aspartate (NMDA)- and KCl-induced phosphorylation of ERK was significantly attenuated in Hpca(-/-) hippocampal slices, as was ionomycin-induced phosphorylation of ERK, whereas forskolin and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulation yielded indistinguishable levels of ERK phosphorylation in both wild-type and Hpca(-/-) slices. Colforsin 187-196 mitogen-activated protein kinase 1 Mus musculus 64-67 17279541-4 2007 N-methyl-D-aspartate (NMDA)- and KCl-induced phosphorylation of ERK was significantly attenuated in Hpca(-/-) hippocampal slices, as was ionomycin-induced phosphorylation of ERK, whereas forskolin and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulation yielded indistinguishable levels of ERK phosphorylation in both wild-type and Hpca(-/-) slices. Colforsin 187-196 hippocalcin Mus musculus 100-104 17158221-5 2007 Stimulation of cAMP production with forskolin/3-isobutyl-1-methylxanthine (50 microM) or dibutyryl-cAMP (1 mM) caused a significant rightward shift in the midpoint activation potential of beta-Ih, whereas expression of either specific small interfering (si)RNA against HCN2 (siHCN2b) or a dominant-negative HCN channel (HCN1-AAA) caused a near-complete inhibition of time-dependent beta-Ih. Colforsin 36-45 hyperpolarization activated cyclic nucleotide gated potassium channel 1 Mus musculus 320-324 17219378-5 2007 After priming with androgen (<1 nM R1881), forskolin or the pesticide dichlorvos enhanced AR activation, whereas interleukin-6 (IL-6) inhibited it. Colforsin 46-55 androgen receptor Homo sapiens 93-95 17140607-5 2007 The maximal increase in Nav 1.8 currents was seen at 0.1microM after the application of a PKC activator, phorbol 12-myristate 13-acetate (PMA) and forskolin. Colforsin 147-156 sodium voltage-gated channel alpha subunit 10 Rattus norvegicus 24-31 17460897-6 2007 According to the protocols which had been applicated in inducing neuronal stem cells and embryonic stem cells differentiate into DA neurons in vitro, the present study provides a protocol by using 50 micromol/L brain derived neurotrophy factor (BDNF), 10 micromol/L forskolin (FSK) and 10 micromol/L dopamine (DA) to induce BMSCs differentiate into DA neurons. Colforsin 266-275 brain derived neurotrophic factor Homo sapiens 245-249 17460897-6 2007 According to the protocols which had been applicated in inducing neuronal stem cells and embryonic stem cells differentiate into DA neurons in vitro, the present study provides a protocol by using 50 micromol/L brain derived neurotrophy factor (BDNF), 10 micromol/L forskolin (FSK) and 10 micromol/L dopamine (DA) to induce BMSCs differentiate into DA neurons. Colforsin 277-280 brain derived neurotrophic factor Homo sapiens 245-249 17464208-5 2007 Forskolin, an adenylyl cyclase activator, stimulated VEGF transcription, and the PKA inhibitor H89 abolished this effect. Colforsin 0-9 vascular endothelial growth factor A Mus musculus 53-57 17598476-3 2007 It is known that inhibition of G(i)-proteins with pertussis toxin blocks redistribution of AQP2 into the apical membrane following the application of vasopressin or forskolin. Colforsin 165-174 aquaporin 2 Rattus norvegicus 91-95 17156132-4 2007 Forskolin is able to decrease the I(K) amplitude recording from neurons of both the LK-S and control group, and prevents apoptosis of granule cells that are induced by LK-S. Dibutyryl cAMP mimicks the effect of forskolin on the modulation of I(K) and, accordingly, the inhibitor of protein kinase A, H-89, aborts the neuron-protective effect induced by forskolin. Colforsin 0-9 cathelicidin antimicrobial peptide Homo sapiens 184-188 17326840-10 2007 In T84 cells, we find digitonin-resistant CLIC1 is present in an intracellular compartment which is concentrated immediately below the apical plasma membrane and the extent of apical polarization is enhanced with forskolin, which activates transepithelial chloride transport and apical membrane traffic in these cells. Colforsin 213-222 chloride intracellular channel 1 Homo sapiens 42-47 17056671-10 2007 Addition of forskolin to histamine-stimulated tissues at 1.4 L(o) induced a relaxation associated with increased HSP20 phosphorylation and reduced MRLC phosphorylation, i.e., there was no additional force suppression. Colforsin 12-21 HSPB6 Sus scrofa 113-118 17359582-7 2007 During BeWo differentiation, caspase-14 mRNA was elevated after 48 h forskolin treatment, while its protein was increased after 24 h. Therefore, caspase-14 is up-regulated during trophoblast differentiation, as represented by the BeWo cell line. Colforsin 69-78 caspase 14 Homo sapiens 29-39 17359582-7 2007 During BeWo differentiation, caspase-14 mRNA was elevated after 48 h forskolin treatment, while its protein was increased after 24 h. Therefore, caspase-14 is up-regulated during trophoblast differentiation, as represented by the BeWo cell line. Colforsin 69-78 caspase 14 Homo sapiens 145-155 17316140-3 2007 A decrease in the intracellular cAMP levels was recorded in KB cells treated with IFN-alpha, whereas forskolin induced an increase in the production of cAMP that was reduced in the presence of IFN-alpha, suggesting a reduction in the activity of adenylate cyclase (AC) induced by IFN-alpha. Colforsin 101-110 interferon alpha 1 Homo sapiens 193-202 17316140-3 2007 A decrease in the intracellular cAMP levels was recorded in KB cells treated with IFN-alpha, whereas forskolin induced an increase in the production of cAMP that was reduced in the presence of IFN-alpha, suggesting a reduction in the activity of adenylate cyclase (AC) induced by IFN-alpha. Colforsin 101-110 interferon alpha 1 Homo sapiens 193-202 17156132-4 2007 Forskolin is able to decrease the I(K) amplitude recording from neurons of both the LK-S and control group, and prevents apoptosis of granule cells that are induced by LK-S. Dibutyryl cAMP mimicks the effect of forskolin on the modulation of I(K) and, accordingly, the inhibitor of protein kinase A, H-89, aborts the neuron-protective effect induced by forskolin. Colforsin 211-220 cathelicidin antimicrobial peptide Homo sapiens 184-188 17156132-4 2007 Forskolin is able to decrease the I(K) amplitude recording from neurons of both the LK-S and control group, and prevents apoptosis of granule cells that are induced by LK-S. Dibutyryl cAMP mimicks the effect of forskolin on the modulation of I(K) and, accordingly, the inhibitor of protein kinase A, H-89, aborts the neuron-protective effect induced by forskolin. Colforsin 353-362 cathelicidin antimicrobial peptide Homo sapiens 184-188 17156132-5 2007 Whereas the expression of Kv2.1 was silenced by Kv2.1 small interfering RNA, the inhibition of forskolin on the current amplitude was significantly reduced. Colforsin 95-104 potassium voltage-gated channel subfamily B member 1 Homo sapiens 26-31 17156132-6 2007 Quantitative RT-PCR and whole-cell recording revealed that the expression of Kv2.1 was elevated in the apoptotic neurons, and forskolin significantly depressed the expression of Kv2.1. Colforsin 126-135 potassium voltage-gated channel subfamily B member 1 Homo sapiens 178-183 17202481-2 2007 The circadian peak of VP gene transcription in the SCN in vitro is completely blocked by a 2 h exposure to tetrodotoxin (TTX) in the culture medium, and this TTX inhibition of VP gene transcription is reversed by exposure of the SCN to either forskolin or potassium depolarization. Colforsin 243-252 arginine vasopressin Rattus norvegicus 22-24 17235686-4 2007 Addition of forskolin, a known inducer of intracellular c-AMP and of oligodendrocyte differentiation, also stimulated CREB phosphorylation in a p38 kinase dependent way. Colforsin 12-21 cAMP responsive element binding protein 1 Homo sapiens 118-122 17235686-4 2007 Addition of forskolin, a known inducer of intracellular c-AMP and of oligodendrocyte differentiation, also stimulated CREB phosphorylation in a p38 kinase dependent way. Colforsin 12-21 mitogen-activated protein kinase 14 Homo sapiens 144-147 17235686-5 2007 Pharmacological inhibition of p38 interfered with the morphological and antigenic changes associated with differentiating oligodendrocytes as well as with the developmental and forskolin-induced expression of myelin basic protein, thereby supporting an essential role for p38 MAPK pathway in oligodendrocyte differentiation. Colforsin 177-186 mitogen-activated protein kinase 14 Homo sapiens 30-33 17235686-5 2007 Pharmacological inhibition of p38 interfered with the morphological and antigenic changes associated with differentiating oligodendrocytes as well as with the developmental and forskolin-induced expression of myelin basic protein, thereby supporting an essential role for p38 MAPK pathway in oligodendrocyte differentiation. Colforsin 177-186 myelin basic protein Homo sapiens 209-229 17235686-5 2007 Pharmacological inhibition of p38 interfered with the morphological and antigenic changes associated with differentiating oligodendrocytes as well as with the developmental and forskolin-induced expression of myelin basic protein, thereby supporting an essential role for p38 MAPK pathway in oligodendrocyte differentiation. Colforsin 177-186 mitogen-activated protein kinase 14 Homo sapiens 272-275 17141199-6 2007 PAO also significantly inhibited the IL-6 production by forskolin, an adenylyl cyclase (AC) activator. Colforsin 56-65 interleukin 6 Mus musculus 37-41 17114792-4 2007 Adenoviral expression of Peri A PKA site mutants in these cells reveals that mutation of serine 517 alone is sufficient to abrogate 95% of PKA (forskolin)-stimulated fatty acid (FA) and glycerol release. Colforsin 144-153 perilipin 1 Mus musculus 25-31 17202481-2 2007 The circadian peak of VP gene transcription in the SCN in vitro is completely blocked by a 2 h exposure to tetrodotoxin (TTX) in the culture medium, and this TTX inhibition of VP gene transcription is reversed by exposure of the SCN to either forskolin or potassium depolarization. Colforsin 243-252 arginine vasopressin Rattus norvegicus 176-178 17008391-2 2007 BMP-6 and BMP-7 both inhibited FSH- and forskolin (FSK)-induced progesterone synthesis and reduced cAMP synthesis independent of the presence or absence of oocytes. Colforsin 40-49 bone morphogenetic protein 6 Rattus norvegicus 0-5 17520403-9 2007 AR mRNA was elevated by forskolin stimulation without FSH and hCG stimulation before LHR mRNA expression. Colforsin 24-33 amphiregulin Homo sapiens 0-2 17520403-11 2007 CONCLUSION: Occurrence of LHR gene expression following FSH stimulation was necessary for the AR gene expression in vivo, and the AR gene was induced by forskolin without LHR gene expression in vitro. Colforsin 153-162 amphiregulin Homo sapiens 130-132 16997881-4 2007 CFTR is absolutely required for forskolin-mediated gland secretion; we used this finding to localize the origin of forskolin-stimulated, CFTR-dependent gland fluid secretion. Colforsin 32-41 CF transmembrane conductance regulator Homo sapiens 0-4 16997881-4 2007 CFTR is absolutely required for forskolin-mediated gland secretion; we used this finding to localize the origin of forskolin-stimulated, CFTR-dependent gland fluid secretion. Colforsin 115-124 CF transmembrane conductance regulator Homo sapiens 0-4 16997881-4 2007 CFTR is absolutely required for forskolin-mediated gland secretion; we used this finding to localize the origin of forskolin-stimulated, CFTR-dependent gland fluid secretion. Colforsin 115-124 CF transmembrane conductance regulator Homo sapiens 137-141 17406063-10 2007 On the other hand, Gsalpha-mediated stimulations of adenylyl cyclase by GTPgammaS, isoproterenol and FSK were significantly augmented in 8Br-cGMP-treated cells. Colforsin 101-104 GNAS complex locus Homo sapiens 19-26 17008391-2 2007 BMP-6 and BMP-7 both inhibited FSH- and forskolin (FSK)-induced progesterone synthesis and reduced cAMP synthesis independent of the presence or absence of oocytes. Colforsin 40-49 bone morphogenetic protein 7 Rattus norvegicus 10-15 17008391-2 2007 BMP-6 and BMP-7 both inhibited FSH- and forskolin (FSK)-induced progesterone synthesis and reduced cAMP synthesis independent of the presence or absence of oocytes. Colforsin 51-54 bone morphogenetic protein 6 Rattus norvegicus 0-5 17008391-2 2007 BMP-6 and BMP-7 both inhibited FSH- and forskolin (FSK)-induced progesterone synthesis and reduced cAMP synthesis independent of the presence or absence of oocytes. Colforsin 51-54 bone morphogenetic protein 7 Rattus norvegicus 10-15 17075029-11 2007 Functional studies in vitro using luciferase reporter gene constructs show that these polymorphisms significantly alter the transcriptional response of CYP11B1 to stimulation by adrenocorticotropic hormone or forskolin. Colforsin 209-218 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 152-159 17008391-7 2007 A specific ERK inhibitor, U0126, increased estradiol production and decreased FSH- and FSK-induced progesterone production and cAMP synthesis. Colforsin 87-90 Eph receptor B1 Rattus norvegicus 11-14 17005903-9 2007 The inhibitory effect of morphine on TRPV1 was abolished by forskolin and 8-bromo-cAMP. Colforsin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 37-42 17939120-9 2007 In this regard, we also compared the effect of IL-2 with other compounds such as basic fibroblast growth factor (bFGF), steel factor, leukemia inhibitory factor and forskolin, and found that the degree of proliferation induced by IL-2 was similar to that induced by bFGF and forskolin. Colforsin 165-174 interleukin 2 Mus musculus 230-234 17182884-10 2007 Furthermore, both atRA and forskolin suppressed HIV-induced mitogen-activated protein kinase 1 and 2 and Stat3 phosphorylation. Colforsin 27-36 mitogen-activated protein kinase 1 Homo sapiens 60-100 17182884-10 2007 Furthermore, both atRA and forskolin suppressed HIV-induced mitogen-activated protein kinase 1 and 2 and Stat3 phosphorylation. Colforsin 27-36 signal transducer and activator of transcription 3 Homo sapiens 105-110 16868751-3 2007 In comparison with the control animals, all Cftr (TgH(neoim)1Hgu) congenic mice had a distinctly reduced basal chloride secretion and a reduced chloride secretion after stimulation with carbachol and forskolin. Colforsin 200-209 cystic fibrosis transmembrane conductance regulator Mus musculus 44-48 16868751-3 2007 In comparison with the control animals, all Cftr (TgH(neoim)1Hgu) congenic mice had a distinctly reduced basal chloride secretion and a reduced chloride secretion after stimulation with carbachol and forskolin. Colforsin 200-209 carboxylesterase 1D Mus musculus 50-53 16782699-9 2006 H-89 reduced the relaxation due to forskolin and dibutyryl cAMP in cav1(+/+) but not in cav1(-/-), suggesting a reduction in PKA activity in cav1(-/-). Colforsin 35-44 caveolin 1, caveolae protein Mus musculus 67-71 17068197-4 2007 Here, using the BON human endocrine cell line, we found that forskolin (FSK)-stimulated NT secretion was reduced by inhibition of Rap1 expression and activity. Colforsin 61-70 RAP1A, member of RAS oncogene family Homo sapiens 130-134 17068197-4 2007 Here, using the BON human endocrine cell line, we found that forskolin (FSK)-stimulated NT secretion was reduced by inhibition of Rap1 expression and activity. Colforsin 72-75 RAP1A, member of RAS oncogene family Homo sapiens 130-134 17068197-5 2007 FSK-stimulated NT secretion was enhanced by overexpression of either wild-type or constitutively active Rap1. Colforsin 0-3 RAP1A, member of RAS oncogene family Homo sapiens 104-108 17053039-0 2007 Transcriptional control of receptor activator of nuclear factor-kappaB ligand by the protein kinase A activator forskolin and the transmembrane glycoprotein 130-activating cytokine, oncostatin M, is exerted through multiple distal enhancers. Colforsin 112-121 TNF superfamily member 11 Homo sapiens 27-77 17124637-7 2007 The function of the HM74a receptor in A431 cells was evaluated for its ability to inhibit forskolin-induced cAMP production. Colforsin 90-99 hydroxycarboxylic acid receptor 2 Homo sapiens 20-25 16973243-7 2007 When forskolin-stimulated cAMP levels were measured, P11 was inactive in this negatively coupled system. Colforsin 5-14 S100 calcium binding protein A10 Homo sapiens 53-56 17196494-7 2007 RESULTS: CRH- or forskolin-stimulated proopiomelanocortin promoter activity was significantly enhanced by local anesthetics. Colforsin 17-26 proopiomelanocortin Rattus norvegicus 38-57 17196494-9 2007 CONCLUSIONS: It was concluded that local anesthetics potentiate the effect of CRH or forskolin on proopiomelanocortin promoter activity without changing the intracellular cyclic AMP level. Colforsin 85-94 proopiomelanocortin Rattus norvegicus 98-117 17001660-6 2006 SLV308 acted as a full 5-HT(1) (A) receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT(1) (A) receptors but with low potency (pEC(50) = 6.3). Colforsin 55-64 5-hydroxytryptamine receptor 1A Homo sapiens 23-43 17123517-4 2006 Quantitative-RT-PCR analysis revealed that the expression of the visfatin mRNA was significantly elevated when treated with forskolin (500 microM), isopreterenol (1-10 microM) and dibutyric cyclic AMP (1 mM) for 24 h, and significantly reduced when treated with insulin (5-50 ng/ml) and dexsamethasone (0.5-250 nM) for 24 h. These results indicate that mammary epithelial cells express the visfatin protein and secrete them into the milk. Colforsin 124-133 nicotinamide phosphoribosyltransferase Bos taurus 65-73 17151284-5 2006 In response to short applications of forskolin, dopamine, or high-potassium concentration, we image an increase in cAMP levels and PKA activity, indicating that this second-messenger pathway can be activated quickly by neural activity. Colforsin 37-46 cathelicidin antimicrobial peptide Rattus norvegicus 115-119 17151284-5 2006 In response to short applications of forskolin, dopamine, or high-potassium concentration, we image an increase in cAMP levels and PKA activity, indicating that this second-messenger pathway can be activated quickly by neural activity. Colforsin 37-46 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 131-134 16835396-6 2006 When cells were incubated with DHEA-S in the presence of forskolin, an additive influence of DHEA-S stimulation of cortisol was recorded over forskolin alone. Colforsin 57-66 sulfotransferase family 2A member 1 Homo sapiens 31-37 16835396-6 2006 When cells were incubated with DHEA-S in the presence of forskolin, an additive influence of DHEA-S stimulation of cortisol was recorded over forskolin alone. Colforsin 57-66 sulfotransferase family 2A member 1 Homo sapiens 93-99 16835396-6 2006 When cells were incubated with DHEA-S in the presence of forskolin, an additive influence of DHEA-S stimulation of cortisol was recorded over forskolin alone. Colforsin 142-151 sulfotransferase family 2A member 1 Homo sapiens 31-37 16835396-6 2006 When cells were incubated with DHEA-S in the presence of forskolin, an additive influence of DHEA-S stimulation of cortisol was recorded over forskolin alone. Colforsin 142-151 sulfotransferase family 2A member 1 Homo sapiens 93-99 16835396-7 2006 The 24-h stimulation of NCI-H295R cells with forskolin increased the expression of steroidogenic acute regulatory protein (StAR), CYP17, CYP21A2, and CYP11A1, whereas only StAR mRNA expression was increased significantly by incubation with DHEA-S. Colforsin 45-54 steroidogenic acute regulatory protein Homo sapiens 83-121 16835396-7 2006 The 24-h stimulation of NCI-H295R cells with forskolin increased the expression of steroidogenic acute regulatory protein (StAR), CYP17, CYP21A2, and CYP11A1, whereas only StAR mRNA expression was increased significantly by incubation with DHEA-S. Colforsin 45-54 steroidogenic acute regulatory protein Homo sapiens 123-127 16835396-7 2006 The 24-h stimulation of NCI-H295R cells with forskolin increased the expression of steroidogenic acute regulatory protein (StAR), CYP17, CYP21A2, and CYP11A1, whereas only StAR mRNA expression was increased significantly by incubation with DHEA-S. Colforsin 45-54 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 130-135 16891388-6 2006 Glibenclamide and clofilium (K(ATP) and KvLQT1 inhibitors) strongly reduced basal transepithelial current, amiloride-sensitive Na(+) current, and forskolin-activated Cl(-) currents, whereas pinacidil, a K(ATP) activator, increased them. Colforsin 146-155 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 40-46 16835396-7 2006 The 24-h stimulation of NCI-H295R cells with forskolin increased the expression of steroidogenic acute regulatory protein (StAR), CYP17, CYP21A2, and CYP11A1, whereas only StAR mRNA expression was increased significantly by incubation with DHEA-S. Colforsin 45-54 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 137-144 16835396-7 2006 The 24-h stimulation of NCI-H295R cells with forskolin increased the expression of steroidogenic acute regulatory protein (StAR), CYP17, CYP21A2, and CYP11A1, whereas only StAR mRNA expression was increased significantly by incubation with DHEA-S. Colforsin 45-54 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 150-157 16835396-7 2006 The 24-h stimulation of NCI-H295R cells with forskolin increased the expression of steroidogenic acute regulatory protein (StAR), CYP17, CYP21A2, and CYP11A1, whereas only StAR mRNA expression was increased significantly by incubation with DHEA-S. Colforsin 45-54 sulfotransferase family 2A member 1 Homo sapiens 240-246 16835396-8 2006 Immunofluorescence analyses revealed strongly elevated expression of hOAT3 by forskolin as well as by DHEA-S stimulation. Colforsin 78-87 solute carrier family 22 member 8 Homo sapiens 69-74 16835396-9 2006 We conclude that the increased cortisol release of adrenocortical cells by DHEA-S and forskolin stimulation is probably due to high expression of the key enzymes of steroid biosynthesis and hOAT3. Colforsin 86-95 solute carrier family 22 member 8 Homo sapiens 190-195 16868306-8 2006 cAMP-elevating agents, including 8-Br-cAMP, forskolin, and IBMX, inhibited EMT and associated oxidative stress induced by TGF-beta1, but inhibition of cAMP pathway with Rp-cAMP, the cAMP analog, and H89, the protein kinase A (PKA) inhibitor, did not block the effect of PGE2. Colforsin 44-53 transforming growth factor beta-1 proprotein Canis lupus familiaris 122-131 17023420-4 2006 Forskolin, isobutylmethylxanthine, and the glucose-dependent insulinotropic peptide inhibited AMPK activity and reduced phosphorylation of the activation loop alpha-Thr(172) via inhibition of calcium/calmodulin-dependent protein kinase kinase-alpha and -beta, but not LKB1. Colforsin 0-9 calcium/calmodulin-dependent protein kinase kinase 1, alpha Mus musculus 192-258 17023420-4 2006 Forskolin, isobutylmethylxanthine, and the glucose-dependent insulinotropic peptide inhibited AMPK activity and reduced phosphorylation of the activation loop alpha-Thr(172) via inhibition of calcium/calmodulin-dependent protein kinase kinase-alpha and -beta, but not LKB1. Colforsin 0-9 serine/threonine kinase 11 Mus musculus 268-272 16959941-5 2006 Treatment with 10 microM forskolin or isoproterenol increased cAMP production and cAMP response element binding protein (CREB) phosphorylation in cardiac fibroblasts and inhibited serum- or TGF-beta-stimulated collagen synthesis by 37% or more. Colforsin 25-34 cAMP responsive element binding protein 1 Homo sapiens 82-119 16966478-3 2006 In guinea pig ventricular myocytes, forskolin-activated whole-cell CFTR currents responded biphasically to external 20 mM BDM: a rapid approximately 2-fold current activation was followed by a slower (tau approximately 20 s) inhibition (to approximately 20% of control). Colforsin 36-45 ATP-binding cassette sub-family C member 7 Cavia porcellus 67-71 17045344-5 2006 Forskolin or dibutyryl cyclic AMP increased CB(2) receptor immunoreactivity, suggesting the involvement of the cyclic AMP-protein kinase A-Cyclic AMP response element pathway in the regulation of CB(2) receptor levels. Colforsin 0-9 cannabinoid receptor 2 Rattus norvegicus 44-58 17045344-5 2006 Forskolin or dibutyryl cyclic AMP increased CB(2) receptor immunoreactivity, suggesting the involvement of the cyclic AMP-protein kinase A-Cyclic AMP response element pathway in the regulation of CB(2) receptor levels. Colforsin 0-9 cannabinoid receptor 2 Rattus norvegicus 196-210 16786190-11 2006 PGE(2), forskolin, TGF-+/-1 and PMA significantly decreased (125)I-ANP B (max) values, NPR-C protein and steady-state NPR-C transcript levels. Colforsin 8-17 natriuretic peptide receptor 2 Rattus norvegicus 67-72 16786190-11 2006 PGE(2), forskolin, TGF-+/-1 and PMA significantly decreased (125)I-ANP B (max) values, NPR-C protein and steady-state NPR-C transcript levels. Colforsin 8-17 natriuretic peptide receptor 3 Rattus norvegicus 87-92 16786190-11 2006 PGE(2), forskolin, TGF-+/-1 and PMA significantly decreased (125)I-ANP B (max) values, NPR-C protein and steady-state NPR-C transcript levels. Colforsin 8-17 natriuretic peptide receptor 3 Rattus norvegicus 118-123 16786190-12 2006 H89, a protein kinase A inhibitor, blocked the reduction of NPR-C mRNA produced by both forskolin and PGE(2.) Colforsin 88-97 natriuretic peptide receptor 3 Rattus norvegicus 60-65 16959941-5 2006 Treatment with 10 microM forskolin or isoproterenol increased cAMP production and cAMP response element binding protein (CREB) phosphorylation in cardiac fibroblasts and inhibited serum- or TGF-beta-stimulated collagen synthesis by 37% or more. Colforsin 25-34 cAMP responsive element binding protein 1 Homo sapiens 121-125 16959941-5 2006 Treatment with 10 microM forskolin or isoproterenol increased cAMP production and cAMP response element binding protein (CREB) phosphorylation in cardiac fibroblasts and inhibited serum- or TGF-beta-stimulated collagen synthesis by 37% or more. Colforsin 25-34 transforming growth factor beta 1 Homo sapiens 190-198 16959941-7 2006 Forskolin or isoproterenol treatment blocked the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) induced by TGF-beta despite the fact that these cAMP-elevating agents stimulated ERK1/2 activation on their own. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 63-104 16959941-7 2006 Forskolin or isoproterenol treatment blocked the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) induced by TGF-beta despite the fact that these cAMP-elevating agents stimulated ERK1/2 activation on their own. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 106-112 16959941-7 2006 Forskolin or isoproterenol treatment blocked the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) induced by TGF-beta despite the fact that these cAMP-elevating agents stimulated ERK1/2 activation on their own. Colforsin 0-9 transforming growth factor beta 1 Homo sapiens 125-133 16959941-7 2006 Forskolin or isoproterenol treatment blocked the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) induced by TGF-beta despite the fact that these cAMP-elevating agents stimulated ERK1/2 activation on their own. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 195-201 17027646-5 2006 In the experiments using heterologous expression system, Delphilin coimmunoprecipitated with GluRdelta2 was dramatically decreased under the condition with forskolin and isobutylmethylxanthine, which led to cAMP-dependent phosphorylation by PKA. Colforsin 156-165 Grid2 interacting protein Homo sapiens 57-66 17079486-3 2006 Transient transfection of LNCaP human prostate cancer cells showed that AR shRNA decreased R1881 induction of the prostate-specific antigen (PSA)-luciferase reporter by 96%, whereas activation by forskolin, interleukin-6, or epidermal growth factor was inhibited 48% to 75%. Colforsin 196-205 androgen receptor Homo sapiens 72-74 17101973-2 2006 Vice versa, AVP (or forskolin) removal and hormones activating PKC cause AQP2 internalization, but the mechanism is unknown. Colforsin 20-29 aquaporin 2 Canis lupus familiaris 73-77 17101973-5 2006 In Madin-Darby canine kidney cells, AQP2 ubiquitination occurs preferentially when present in the apical membrane, is transiently increased with forskolin removal or PKC activation, and precedes its internalization. Colforsin 145-154 aquaporin 2 Canis lupus familiaris 36-40 16980356-7 2006 Docking of the inhibitor forskolin to GLUT1 and to a control model revealed significant differences, indicating that we may identify accurate models despite low sequence identity between target sequences and templates. Colforsin 25-34 solute carrier family 2 member 1 Homo sapiens 38-43 16928405-6 2006 The stimulatory effect of PACAP on Id3 mRNA levels was mimicked by adenylate cyclase/PKA activators like forskolin and dibutyryl cyclic AMP. Colforsin 105-114 adenylate cyclase activating polypeptide 1 Rattus norvegicus 26-31 16928405-6 2006 The stimulatory effect of PACAP on Id3 mRNA levels was mimicked by adenylate cyclase/PKA activators like forskolin and dibutyryl cyclic AMP. Colforsin 105-114 inhibitor of DNA binding 3, HLH protein Rattus norvegicus 35-38 16889987-0 2006 A forskolin derivative, FSK88, induces apoptosis in human gastric cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release. Colforsin 2-11 BCL2 apoptosis regulator Homo sapiens 137-142 16889987-0 2006 A forskolin derivative, FSK88, induces apoptosis in human gastric cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release. Colforsin 2-11 cytochrome c, somatic Homo sapiens 219-231 16787963-6 2006 In addition, SNAT2 expression in the mammary gland was induced by forskolin and PMA, inducers of PKA and PKC signaling pathways, respectively. Colforsin 66-75 solute carrier family 38, member 2 Rattus norvegicus 13-18 17192570-10 2006 Second, we showed that TNF-alpha reduced significantly the forskolin-stimulated LHRH release and that the CB1-r antagonist AM251 (10(-5) M) blocked that inhibition, supporting the hypothesis that TNF-alpha inhibits LHRH release, acting at least in part by activating the endocannabinoid system. Colforsin 59-68 tumor necrosis factor Rattus norvegicus 23-32 17192570-10 2006 Second, we showed that TNF-alpha reduced significantly the forskolin-stimulated LHRH release and that the CB1-r antagonist AM251 (10(-5) M) blocked that inhibition, supporting the hypothesis that TNF-alpha inhibits LHRH release, acting at least in part by activating the endocannabinoid system. Colforsin 59-68 tumor necrosis factor Rattus norvegicus 196-205 17080404-4 2006 Treatment with forskolin increased cortisol secretion and stimulated transcription of all the steroidogenic genes except SULT2A1. Colforsin 15-24 sulfotransferase family 2A member 1 Homo sapiens 121-128 17010372-9 2006 In electrophysiologic studies, CXCL12 decreases forskolin- and isoproterenol-induced voltage-gated L-type calcium channel activation. Colforsin 48-57 C-X-C motif chemokine ligand 12 Homo sapiens 31-37 18404461-6 2006 Furthermore, functional assays of inhibition of 10 muM forskolin-stimulated cAMP production via the adenosine A3 receptor revealed that the new trisubstituted adenosine derivatives behave as full agonist of this receptor subtype. Colforsin 55-64 latexin Homo sapiens 51-54 17014689-7 2006 Concomitant to this attenuation in the forskolin response was a reduction in the amount of G(i alpha) protein coupled to MT1 receptors and an increase in [32P] azidoanilido GTP incorporation into G(i) proteins. Colforsin 39-48 metallothionein-1 Cricetulus griseus 121-124 17057711-7 2006 Healthy individuals homozygous for this haplotype exhibited reduced experimental pain sensitivity, and forskolin-stimulated immortalized leukocytes from haplotype carriers upregulated GCH1 less than did controls. Colforsin 103-112 GTP cyclohydrolase 1 Homo sapiens 184-188 16973907-4 2006 When isoforms were expressed at levels to achieve comparable forskolin-stimulated AC activity, only gene transfer of AC6 significantly enhanced PKA-dependent vasodilator-stimulated phosphoprotein (VASP) phosphorylation and arborization responses. Colforsin 61-70 adenylate cyclase 6 Homo sapiens 117-120 16950788-4 2006 RGS2 was also up-regulated by extracellular ATP, which selectively activates G(q), as well as by forskolin and phorbol myristate acetate, which activate targets downstream of G(s) and G(q), respectively. Colforsin 97-106 regulator of G-protein signaling 2 Mus musculus 0-4 16950788-8 2006 Interestingly, forskolin treatment of wild type but not rgs2(-/-) osteoblasts suppressed both endothelin-stimulated accumulation of inositol phosphates and nucleotide-stimulated calcium release, indicating that up-regulation of RGS2 by G(s) signaling desensitizes G(q) signals. Colforsin 15-24 regulator of G-protein signaling 2 Mus musculus 228-232 17041727-0 2006 Forskolin and 8-cyclopentyltheophylline synergistically facilitate the neuronal activity in the CA2 area of rat hippocampus via cAMP and non-cAMP cascades. Colforsin 0-9 carbonic anhydrase 2 Rattus norvegicus 96-99 17041727-8 2006 Co-application of forskolin and Ro 20-1724, a cAMP-specific phosphodiesterase-IV inhibitor, only increased PSs in CA2 to 1.3 mV but increased cAMP content by 4.4 times. Colforsin 18-27 carbonic anhydrase 2 Rattus norvegicus 114-117 16873402-4 2006 beta(2)AR stimulation increased l-arginine transport, as did cyclic AMP elevation with either forskolin or dibutyryl cyclic AMP, and this increase was inhibitable by N-ethylmaleimide. Colforsin 94-103 adrenoceptor beta 2 Homo sapiens 0-9 16973907-7 2006 In contrast, only the expression of AC1 enhanced forskolin-stimulated association of ERK with AC, demonstrated by coimmuno-isolation of ERK with Flag-tagged AC1, but not with Flag-tagged AC6. Colforsin 49-58 adenylate cyclase 1 Homo sapiens 36-39 16973907-7 2006 In contrast, only the expression of AC1 enhanced forskolin-stimulated association of ERK with AC, demonstrated by coimmuno-isolation of ERK with Flag-tagged AC1, but not with Flag-tagged AC6. Colforsin 49-58 mitogen-activated protein kinase 1 Homo sapiens 85-88 16973907-7 2006 In contrast, only the expression of AC1 enhanced forskolin-stimulated association of ERK with AC, demonstrated by coimmuno-isolation of ERK with Flag-tagged AC1, but not with Flag-tagged AC6. Colforsin 49-58 mitogen-activated protein kinase 1 Homo sapiens 136-139 16973907-7 2006 In contrast, only the expression of AC1 enhanced forskolin-stimulated association of ERK with AC, demonstrated by coimmuno-isolation of ERK with Flag-tagged AC1, but not with Flag-tagged AC6. Colforsin 49-58 adenylate cyclase 1 Homo sapiens 157-160 16973907-9 2006 Indeed, we observed similar isoform-dependent association of AC1 with ERK, activation of ERK by stimulation of AC1 with forskolin, and AC1-dependent lengthening of doubling time, indicating that these properties of AC1 are cell autologous and likely result from AC1-dependent protein-protein interactions. Colforsin 120-129 mitogen-activated protein kinase 1 Homo sapiens 89-92 16973907-9 2006 Indeed, we observed similar isoform-dependent association of AC1 with ERK, activation of ERK by stimulation of AC1 with forskolin, and AC1-dependent lengthening of doubling time, indicating that these properties of AC1 are cell autologous and likely result from AC1-dependent protein-protein interactions. Colforsin 120-129 adenylate cyclase 1 Homo sapiens 111-114 16973907-9 2006 Indeed, we observed similar isoform-dependent association of AC1 with ERK, activation of ERK by stimulation of AC1 with forskolin, and AC1-dependent lengthening of doubling time, indicating that these properties of AC1 are cell autologous and likely result from AC1-dependent protein-protein interactions. Colforsin 120-129 adenylate cyclase 1 Homo sapiens 111-114 16973907-9 2006 Indeed, we observed similar isoform-dependent association of AC1 with ERK, activation of ERK by stimulation of AC1 with forskolin, and AC1-dependent lengthening of doubling time, indicating that these properties of AC1 are cell autologous and likely result from AC1-dependent protein-protein interactions. Colforsin 120-129 adenylate cyclase 1 Homo sapiens 111-114 16973907-9 2006 Indeed, we observed similar isoform-dependent association of AC1 with ERK, activation of ERK by stimulation of AC1 with forskolin, and AC1-dependent lengthening of doubling time, indicating that these properties of AC1 are cell autologous and likely result from AC1-dependent protein-protein interactions. Colforsin 120-129 adenylate cyclase 1 Homo sapiens 111-114 16465464-3 2006 We found that incubation of N2a/tau441 with forskolin, a specific activator of cAMP-dependent protein kinase (PKA), induced an increased phosphorylation level of tau at both PKA and non-PKA sites in a dose- and time-dependent manner, and the hyperphosphorylation of tau was positively correlated with the elevation of PKA activity. Colforsin 44-53 mitogen-activated protein kinase kinase kinase 14 Mus musculus 110-113 16940990-5 2006 Effects on S1P3 -mediated inhibition of forskolin-induced cAMP accumulation and on binding to alpha(1A)-adrenoceptors were also investigated. Colforsin 40-49 sphingosine-1-phosphate receptor 3 Homo sapiens 11-15 16639710-6 2006 CBX caused a dose-dependent inhibition (significant > or = 90 microM) of the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells formed in 7- to 8-day marrow cultures stimulated by parathyroid hormone (PTH; 10 nM) or forskolin (FSK; 1 microM). Colforsin 251-260 acid phosphatase 5, tartrate resistant Mus musculus 127-131 16639710-6 2006 CBX caused a dose-dependent inhibition (significant > or = 90 microM) of the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells formed in 7- to 8-day marrow cultures stimulated by parathyroid hormone (PTH; 10 nM) or forskolin (FSK; 1 microM). Colforsin 262-265 acid phosphatase 5, tartrate resistant Mus musculus 127-131 17543219-8 2006 Upon stimulation with forskolin, AQP2 is translocated to the cell surface. Colforsin 22-31 aquaporin 2 Homo sapiens 33-37 16989818-3 2006 Specific ligand binding and ligand-induced inhibition of forskolin-stimulated cAMP accumulation were observed with human embryonic kidney epithelial cell line (HEK293) cells expressing wild-type CB1 and CB2, as well as CB1D6.30N and CB2D6.30N mutant receptors. Colforsin 57-66 cannabinoid receptor 1 Homo sapiens 195-198 16989818-3 2006 Specific ligand binding and ligand-induced inhibition of forskolin-stimulated cAMP accumulation were observed with human embryonic kidney epithelial cell line (HEK293) cells expressing wild-type CB1 and CB2, as well as CB1D6.30N and CB2D6.30N mutant receptors. Colforsin 57-66 cannabinoid receptor 2 Homo sapiens 203-206 16840549-10 2006 The addition of forskolin to increase cAMP activated the CT promoter, probably by the interaction of DREAM with cAMP-responsive element binding proteins, independent on the activation by Ca(2+). Colforsin 16-25 calcitonin related polypeptide alpha Homo sapiens 57-59 16840549-10 2006 The addition of forskolin to increase cAMP activated the CT promoter, probably by the interaction of DREAM with cAMP-responsive element binding proteins, independent on the activation by Ca(2+). Colforsin 16-25 potassium voltage-gated channel interacting protein 3 Homo sapiens 101-106 16859841-6 2006 A 3-5-fold stimulation of TCTP synthesis by forskolin and phorbolester in T24 cells and promoter-reporter experiments using CRE-deletion constructs suggested a transcriptional control by cAMP signaling via phosphorylation dependent activation of CRE/CREB interaction. Colforsin 44-53 tumor protein, translationally-controlled 1 Homo sapiens 26-30 17032742-9 2006 Studies of EGR-1 regulation in primary granulosa cells cultured with forskolin showed that levels of EGR-1 mRNA were low at 0 h, highly increased at 6 h post-forskolin (P < 0.05), and declined to steady state thereafter. Colforsin 69-78 early growth response 1 Bos taurus 11-16 17032742-9 2006 Studies of EGR-1 regulation in primary granulosa cells cultured with forskolin showed that levels of EGR-1 mRNA were low at 0 h, highly increased at 6 h post-forskolin (P < 0.05), and declined to steady state thereafter. Colforsin 69-78 early growth response 1 Bos taurus 101-106 17032742-9 2006 Studies of EGR-1 regulation in primary granulosa cells cultured with forskolin showed that levels of EGR-1 mRNA were low at 0 h, highly increased at 6 h post-forskolin (P < 0.05), and declined to steady state thereafter. Colforsin 158-167 early growth response 1 Bos taurus 101-106 17032742-10 2006 Immunoblotting confirmed forskolin-induced EGR-1 protein in cultures. Colforsin 25-34 early growth response 1 Bos taurus 43-48 16465464-3 2006 We found that incubation of N2a/tau441 with forskolin, a specific activator of cAMP-dependent protein kinase (PKA), induced an increased phosphorylation level of tau at both PKA and non-PKA sites in a dose- and time-dependent manner, and the hyperphosphorylation of tau was positively correlated with the elevation of PKA activity. Colforsin 44-53 mitogen-activated protein kinase kinase kinase 14 Mus musculus 174-177 16465464-3 2006 We found that incubation of N2a/tau441 with forskolin, a specific activator of cAMP-dependent protein kinase (PKA), induced an increased phosphorylation level of tau at both PKA and non-PKA sites in a dose- and time-dependent manner, and the hyperphosphorylation of tau was positively correlated with the elevation of PKA activity. Colforsin 44-53 mitogen-activated protein kinase kinase kinase 14 Mus musculus 174-177 16465464-3 2006 We found that incubation of N2a/tau441 with forskolin, a specific activator of cAMP-dependent protein kinase (PKA), induced an increased phosphorylation level of tau at both PKA and non-PKA sites in a dose- and time-dependent manner, and the hyperphosphorylation of tau was positively correlated with the elevation of PKA activity. Colforsin 44-53 mitogen-activated protein kinase kinase kinase 14 Mus musculus 174-177 16465464-4 2006 When the cells were transitorily incubated with forskolin, a temporary activation of PKA with a sustained and almost equally graded tau hyperphosphorylation at some non-PKA sites was observed. Colforsin 48-57 mitogen-activated protein kinase kinase kinase 14 Mus musculus 85-88 16829626-6 2006 Activation was potentiated by low concentration of forskolin and inhibited by glibenclamide and CFTR(inh)-172 [3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl-)methylene]-2-thioxo-4-thiazolidinone]but not by calixarene or DIDS (4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid). Colforsin 51-60 CF transmembrane conductance regulator Homo sapiens 96-100 16465464-4 2006 When the cells were transitorily incubated with forskolin, a temporary activation of PKA with a sustained and almost equally graded tau hyperphosphorylation at some non-PKA sites was observed. Colforsin 48-57 mitogen-activated protein kinase kinase kinase 14 Mus musculus 169-172 16982748-5 2006 CaSR signaling in PC-3 cells was evaluated by measuring the elevated [Ca2+]o-dependent inhibition of cyclic AMP accumulation, induced by either prostaglandin E2 or forskolin. Colforsin 164-173 calcium sensing receptor Homo sapiens 0-4 16782232-4 2006 We also show that p38 activation occurs either upstream of or parallel to the requirement for cyclic AMP to block apoptosis of post-mitotic cells, since the cyclic AMP-producing agent forskolin did not prevent p38 phosphorylation induced by anisomycin. Colforsin 184-193 mitogen activated protein kinase 14 Rattus norvegicus 18-21 16924422-0 2006 Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells. Colforsin 0-9 acetylcholinesterase Mus musculus 44-64 16924422-3 2006 We investigated an alternative bioscavenger approach using forskolin, an inducer of intracellular cyclic AMP (cAMP), which activates AChE promoter and up-regulates its expression. Colforsin 59-68 acetylcholinesterase Mus musculus 133-137 16924422-4 2006 A mouse neuronal cell line, Neuro 2A, was treated with various doses of forskolin and analysis of the expressed enzyme indicates that the AChE activity was significantly increased in cells exposed to repeated administration of the drug every other day for 7-10 days. Colforsin 72-81 acetylcholinesterase Mus musculus 138-142 16924422-7 2006 In parallel with the rise in the AChE level, the morphology of forskolin-treated cells showed neurite growth with increasing doses. Colforsin 63-72 acetylcholinesterase Mus musculus 33-37 16924422-9 2006 These results indicate that transcriptional inducers, such as forskolin, can sufficiently up-regulate cellular AChE production and protect cells against organophosphate toxicity. Colforsin 62-71 acetylcholinesterase Mus musculus 111-115 16870611-7 2006 Furthermore, forskolin-induced translocation of MARCKS-GFP was almost completely inhibited by U73122, a putative inhibitor of phospholipase C. These observations were verified in two different ways by demonstrating 1) forskolin-induced translocation of the GFP-tagged C1 domain of PKCgamma and 2) translocation of PKCalpha-DsRed and PKCepsilon-GFP. Colforsin 13-22 myristoylated alanine rich protein kinase C substrate Rattus norvegicus 48-54 16870611-7 2006 Furthermore, forskolin-induced translocation of MARCKS-GFP was almost completely inhibited by U73122, a putative inhibitor of phospholipase C. These observations were verified in two different ways by demonstrating 1) forskolin-induced translocation of the GFP-tagged C1 domain of PKCgamma and 2) translocation of PKCalpha-DsRed and PKCepsilon-GFP. Colforsin 13-22 protein kinase C, gamma Rattus norvegicus 281-295 16870611-7 2006 Furthermore, forskolin-induced translocation of MARCKS-GFP was almost completely inhibited by U73122, a putative inhibitor of phospholipase C. These observations were verified in two different ways by demonstrating 1) forskolin-induced translocation of the GFP-tagged C1 domain of PKCgamma and 2) translocation of PKCalpha-DsRed and PKCepsilon-GFP. Colforsin 13-22 protein kinase C, alpha Rattus norvegicus 314-322 16870611-7 2006 Furthermore, forskolin-induced translocation of MARCKS-GFP was almost completely inhibited by U73122, a putative inhibitor of phospholipase C. These observations were verified in two different ways by demonstrating 1) forskolin-induced translocation of the GFP-tagged C1 domain of PKCgamma and 2) translocation of PKCalpha-DsRed and PKCepsilon-GFP. Colforsin 218-227 myristoylated alanine rich protein kinase C substrate Rattus norvegicus 48-54 16870611-7 2006 Furthermore, forskolin-induced translocation of MARCKS-GFP was almost completely inhibited by U73122, a putative inhibitor of phospholipase C. These observations were verified in two different ways by demonstrating 1) forskolin-induced translocation of the GFP-tagged C1 domain of PKCgamma and 2) translocation of PKCalpha-DsRed and PKCepsilon-GFP. Colforsin 218-227 protein kinase C, gamma Rattus norvegicus 281-295 16870611-7 2006 Furthermore, forskolin-induced translocation of MARCKS-GFP was almost completely inhibited by U73122, a putative inhibitor of phospholipase C. These observations were verified in two different ways by demonstrating 1) forskolin-induced translocation of the GFP-tagged C1 domain of PKCgamma and 2) translocation of PKCalpha-DsRed and PKCepsilon-GFP. Colforsin 218-227 protein kinase C, alpha Rattus norvegicus 314-322 16870611-8 2006 In addition, PKC inhibitors reduced forskolin-induced insulin secretion in both INS-1 cells and rat islets. Colforsin 36-45 protein kinase C, alpha Rattus norvegicus 13-16 16647886-5 2006 Activation of AC with Forskolin or PKA with PTH(1-31) or cell-permeable cAMP analogues increased osteoblastic Jagged1. Colforsin 22-31 jagged canonical Notch ligand 1 Rattus norvegicus 110-117 16611736-5 2006 Forskolin, a stimulator of cAMP production, and dibutyryl cAMP also reduced the production of OPG. Colforsin 0-9 TNF receptor superfamily member 11b Homo sapiens 94-97 16837116-8 2006 A forskolin treatment of 3T3-L1 preadipocyte cells induced an increased endogenous expression of HSD11B1. Colforsin 2-11 hydroxysteroid 11-beta dehydrogenase 1 Mus musculus 97-104 16837116-9 2006 By transfection studies using the hHSD11B1 luciferase constructs, it appears that C/EBPbeta was strongly involved in this induction, as the forskolin stimulation was suppressed after mutation of the C/EBPbeta binding site. Colforsin 140-149 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 34-42 16837116-9 2006 By transfection studies using the hHSD11B1 luciferase constructs, it appears that C/EBPbeta was strongly involved in this induction, as the forskolin stimulation was suppressed after mutation of the C/EBPbeta binding site. Colforsin 140-149 CCAAT enhancer binding protein beta Homo sapiens 82-91 16837116-9 2006 By transfection studies using the hHSD11B1 luciferase constructs, it appears that C/EBPbeta was strongly involved in this induction, as the forskolin stimulation was suppressed after mutation of the C/EBPbeta binding site. Colforsin 140-149 CCAAT enhancer binding protein beta Homo sapiens 199-208 16837116-10 2006 Part of the mechanism involved the increase of nuclear C/EBPbeta protein levels induced by forskolin and a phosphorylation step associated with an enhanced binding of the transcription factor to its site. Colforsin 91-100 CCAAT enhancer binding protein beta Homo sapiens 55-64 17039426-9 2006 An adenylyl cyclase activator, forskolin, was shown to induce Ang-1 mRNA expression, whereas the protein kinase A inhibitor, H-89, blocked the PTH (1-34)-mediated expression of Ang-1 mRNA. Colforsin 31-40 angiopoietin 1 Homo sapiens 62-67 17039426-9 2006 An adenylyl cyclase activator, forskolin, was shown to induce Ang-1 mRNA expression, whereas the protein kinase A inhibitor, H-89, blocked the PTH (1-34)-mediated expression of Ang-1 mRNA. Colforsin 31-40 angiopoietin 1 Homo sapiens 177-182 16846840-7 2006 The functionality of the gp120-induced MOR in these cells was confirmed based on morphine"s inhibition of forskolin-induced intracellular cAMP, which was naloxone reversible. Colforsin 106-115 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 25-30 16846840-7 2006 The functionality of the gp120-induced MOR in these cells was confirmed based on morphine"s inhibition of forskolin-induced intracellular cAMP, which was naloxone reversible. Colforsin 106-115 opioid receptor mu 1 Homo sapiens 39-42 16844083-5 2006 NAGly also inhibited forskolin-induced cAMP production in a pertussis toxin-sensitive manner in the GPR18-transfected CHO cells. Colforsin 21-30 N-arachidonyl glycine receptor Cricetulus griseus 100-105 16879162-5 2006 Synergistic activation of the prolactin promoter by Pitx factors and Pit-1 is involved not only in basal condition, but also in responsiveness to forskolin, thyrotrophin-releasing-hormone and epidermal growth factor. Colforsin 146-155 prolactin Homo sapiens 30-39 17003268-5 2006 Acutely, the protein kinase A (PKA) and epac pathway stimulant forskolin normalized insulin secretion in ucp2-OE rat islets and beta-TC-6f7 beta-cells, an effect blocked by specific PKA inhibitors but not mimicked by epac agonists. Colforsin 63-72 uncoupling protein 2 Rattus norvegicus 105-109 17003268-5 2006 Acutely, the protein kinase A (PKA) and epac pathway stimulant forskolin normalized insulin secretion in ucp2-OE rat islets and beta-TC-6f7 beta-cells, an effect blocked by specific PKA inhibitors but not mimicked by epac agonists. Colforsin 63-72 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 182-185 17003268-7 2006 In ucp2-OE islets, forskolin inhibited ATP-dependent potassium (K(ATP)) channel currents and (86)Rb(+) efflux, indicative of K(ATP) block. Colforsin 19-28 uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus 3-7 17003268-9 2006 Chronic exposure to forskolin increased ucp2 mRNA and exaggerated basal secretion but not GSIS. Colforsin 20-29 uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus 40-44 16879162-5 2006 Synergistic activation of the prolactin promoter by Pitx factors and Pit-1 is involved not only in basal condition, but also in responsiveness to forskolin, thyrotrophin-releasing-hormone and epidermal growth factor. Colforsin 146-155 POU class 1 homeobox 1 Homo sapiens 69-74 16675540-5 2006 Treatments with hCG, forskolin, or phorbol 12 myristate 13-acetate stimulated Runx1 mRNA expression. Colforsin 21-30 RUNX family transcription factor 1 Rattus norvegicus 78-83 16790488-11 2006 In BeWo cells, a caspase-3 band of 20-16 kDa was evident after 1 h of treatment with p-NP and after 24 h of treatment with 17beta-E2 or forskolin. Colforsin 136-145 caspase 3 Homo sapiens 17-26 16621159-2 2006 Forskolin increases cAMP and activates Akt and NMDA receptors. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 39-42 16621159-3 2006 In neurons treated with forskolin, intracellular calcium increased to 296 +/- 38% and this was completely prevented by inhibition of Akt. Colforsin 24-33 AKT serine/threonine kinase 1 Homo sapiens 133-136 16899723-7 2006 WIN55,212-2 blocked this forskolin-mediated enhancement, showing that CB1 receptor activation interferes with the adenylyl cyclase-protein kinase A cascade, which participates in LTP induction. Colforsin 25-34 cannabinoid receptor 1 Homo sapiens 70-73 16807246-6 2006 Our results showed that among several bioactive agents tested, only forskolin and three isoforms of TGFbeta (TGFbeta1-TGFbeta3) significantly induced syndecan-1, but not syndecan-4, expression on various epithelial cells. Colforsin 68-77 syndecan 1 Homo sapiens 150-160 16598781-7 2006 Besides acting through the CRE-like region (-0.96 kb) of the RANKL gene promoter, forskolin (FK) treatment transactivates the RANKL gene by antagonizing the function of Runx2, by reducing Runx2 mRNA expression and by opening the chromatin conformation far upstream (more than 40 kb) of the RANKL gene. Colforsin 82-91 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 61-66 16598781-7 2006 Besides acting through the CRE-like region (-0.96 kb) of the RANKL gene promoter, forskolin (FK) treatment transactivates the RANKL gene by antagonizing the function of Runx2, by reducing Runx2 mRNA expression and by opening the chromatin conformation far upstream (more than 40 kb) of the RANKL gene. Colforsin 82-91 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 126-131 16598781-7 2006 Besides acting through the CRE-like region (-0.96 kb) of the RANKL gene promoter, forskolin (FK) treatment transactivates the RANKL gene by antagonizing the function of Runx2, by reducing Runx2 mRNA expression and by opening the chromatin conformation far upstream (more than 40 kb) of the RANKL gene. Colforsin 82-91 runt related transcription factor 2 Mus musculus 169-174 16598781-7 2006 Besides acting through the CRE-like region (-0.96 kb) of the RANKL gene promoter, forskolin (FK) treatment transactivates the RANKL gene by antagonizing the function of Runx2, by reducing Runx2 mRNA expression and by opening the chromatin conformation far upstream (more than 40 kb) of the RANKL gene. Colforsin 82-91 runt related transcription factor 2 Mus musculus 188-193 16598781-7 2006 Besides acting through the CRE-like region (-0.96 kb) of the RANKL gene promoter, forskolin (FK) treatment transactivates the RANKL gene by antagonizing the function of Runx2, by reducing Runx2 mRNA expression and by opening the chromatin conformation far upstream (more than 40 kb) of the RANKL gene. Colforsin 82-91 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 126-131 16820147-10 2006 In summary, although we have shown that the P2Y(14) receptor is functionally expressed in human neutrophils (coupling to inhibition of forskolin-induced cAMP and ERK1/2 activation) it does not modulate neutrophil degranulation (assessed by monitoring elastase release). Colforsin 135-144 purinergic receptor P2Y14 Homo sapiens 44-60 16574993-4 2006 Whereas chronic (24 h) exposure to both agents inhibited FSK-stimulated transcellular and apical membrane ISC-cAMP, the effects of DOPPA were more complex: this conventional PKC-beta-specific agonist also stimulated Ba2+-sensitive basolateral membrane-dependent facilitation of transcellular ISC-cAMP. Colforsin 57-60 protein kinase C beta Homo sapiens 174-182 16478976-6 2006 ANG II accumulation was associated with significant inhibition of both basal (control, 15.5 +/- 2.8 vs. ANG II, 9.1 +/- 2.4 pmol/mg protein, P < 0.05) and forskolin-stimulated cAMP signaling (forskolin, 68.7 +/- 8.6 vs. forskolin + ANG II, 42.8 +/- 13.8 pmol/mg protein, P < 0.01). Colforsin 158-167 angiotensinogen Homo sapiens 0-6 16478976-6 2006 ANG II accumulation was associated with significant inhibition of both basal (control, 15.5 +/- 2.8 vs. ANG II, 9.1 +/- 2.4 pmol/mg protein, P < 0.05) and forskolin-stimulated cAMP signaling (forskolin, 68.7 +/- 8.6 vs. forskolin + ANG II, 42.8 +/- 13.8 pmol/mg protein, P < 0.01). Colforsin 195-204 angiotensinogen Homo sapiens 0-6 16478976-6 2006 ANG II accumulation was associated with significant inhibition of both basal (control, 15.5 +/- 2.8 vs. ANG II, 9.1 +/- 2.4 pmol/mg protein, P < 0.05) and forskolin-stimulated cAMP signaling (forskolin, 68.7 +/- 8.6 vs. forskolin + ANG II, 42.8 +/- 13.8 pmol/mg protein, P < 0.01). Colforsin 195-204 angiotensinogen Homo sapiens 0-6 16645176-9 2006 Non-CF bronchiolar preparations displayed larger short circuit current and fluid secretion in responses to forskolin than non-CF bronchial preparations, suggesting that CFTR-dependent Cl(-) transport may play a more important role in the regulation of fluid transport in small airways than in large airways. Colforsin 107-116 CF transmembrane conductance regulator Homo sapiens 169-173 16732058-4 2006 Here we report that pancreatic islets from iPLA(2)beta-null mice have impaired insulin secretory responses to D-glucose and forskolin. Colforsin 124-133 phospholipase A2, group VI Mus musculus 43-54 16274952-9 2006 THP-1 cells incubated with conditioned media (5x) from transfected cells, in the presence of forskolin (1 microM) and isobutylmethylxanthine (50 microM), showed an increase in cAMP production over media from mock-transfected cells alone. Colforsin 93-102 GLI family zinc finger 2 Homo sapiens 0-5 16707627-10 2006 Although stimulation of adenylate cyclase with forskolin did not increase IL-4 secretion on its own, it potentiated the effect of Pasteurella multocida toxin by 2-fold and ionomycin by 3-fold. Colforsin 47-56 inorganic triphosphatase Pasteurella multocida 24-41 16707627-11 2006 Both forskolin and stimulation of A(2B) receptors up-regulated NFATc1 protein levels. Colforsin 5-14 nuclear factor of activated T cells 1 Homo sapiens 63-69 16644915-2 2006 We found that forskolin/IBMX also activate ERK1/2 phosphorylation in intestinal and pancreatic proglucagon-producing cell lines. Colforsin 14-23 mitogen-activated protein kinase 3 Homo sapiens 43-49 16644915-3 2006 The MEK inhibitors PD98059 and U0126 were found to repress the expression of proglucagon promoter as well as endogenous proglucagon mRNA in two intestinal proglucagon-producing cell lines and to block the stimulatory effect of forskolin/IBMX on proglucagon mRNA expression. Colforsin 227-236 mitogen-activated protein kinase kinase 7 Homo sapiens 4-7 16644915-5 2006 Forskolin could activate ERK1/2 phosphorylation and proglucagon gene transcription on its own, whereas forskolin plus IBMX are required to effectively activate the PKA pathway in the proglucagon-producing cells. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 25-31 16678346-6 2006 However, NAMDA enhanced the activation of ERK and CREB in the presence of forskolin (1.7-fold increase for pCREB, 2.1-fold increase for pERK2, p<0.05 from forskolin). Colforsin 74-83 mitogen-activated protein kinase 1 Homo sapiens 42-45 16842630-5 2006 RESULTS: In the present studies we investigated the hypothesis that the mu opioid receptor (MOP) agonist morphine can modulate forskolin-potentiated capsaicin responses through a cAMP-dependent PKA pathway. Colforsin 127-136 opioid receptor mu 1 Homo sapiens 72-90 16842630-5 2006 RESULTS: In the present studies we investigated the hypothesis that the mu opioid receptor (MOP) agonist morphine can modulate forskolin-potentiated capsaicin responses through a cAMP-dependent PKA pathway. Colforsin 127-136 opioid receptor mu 1 Homo sapiens 92-95 16678346-6 2006 However, NAMDA enhanced the activation of ERK and CREB in the presence of forskolin (1.7-fold increase for pCREB, 2.1-fold increase for pERK2, p<0.05 from forskolin). Colforsin 74-83 cAMP responsive element binding protein 1 Homo sapiens 50-54 16678346-6 2006 However, NAMDA enhanced the activation of ERK and CREB in the presence of forskolin (1.7-fold increase for pCREB, 2.1-fold increase for pERK2, p<0.05 from forskolin). Colforsin 158-167 mitogen-activated protein kinase 1 Homo sapiens 42-45 16678346-6 2006 However, NAMDA enhanced the activation of ERK and CREB in the presence of forskolin (1.7-fold increase for pCREB, 2.1-fold increase for pERK2, p<0.05 from forskolin). Colforsin 158-167 cAMP responsive element binding protein 1 Homo sapiens 50-54 16678346-8 2006 Cleavage of caspase-3 and poly-(ADP-ribose)-polymerase was additively reduced in cultures treated with NAMDA and forskolin simultaneously, but not in the presence of U0126. Colforsin 113-122 caspase 3 Homo sapiens 12-54 16678346-9 2006 The data showed that NAMDA enhances forskolin-induced ERK-CREB activation and potentiates forskolin-induced resistance to apoptosis. Colforsin 36-45 mitogen-activated protein kinase 1 Homo sapiens 54-57 16678346-9 2006 The data showed that NAMDA enhances forskolin-induced ERK-CREB activation and potentiates forskolin-induced resistance to apoptosis. Colforsin 36-45 cAMP responsive element binding protein 1 Homo sapiens 58-62 16798884-7 2006 The molecular interaction between the Y(1) receptor and TH was demonstrated by the fact that NPY markedly inhibited the forskolin-induced luciferin activity in Y(1) receptor-expressing SK-N-MC cells transfected with a TH promoter sequence. Colforsin 120-129 neuropeptide Y Homo sapiens 93-96 16760337-6 2006 Finally, insulin release induced by cAMP-raising agents, such as forskolin plus 3-isobutyl-1-methylxanthine or the calcium ionophore ionomycin, was significantly inhibited by 10 and 100 pM adrenomedullin. Colforsin 65-74 insulin Homo sapiens 9-16 16760337-6 2006 Finally, insulin release induced by cAMP-raising agents, such as forskolin plus 3-isobutyl-1-methylxanthine or the calcium ionophore ionomycin, was significantly inhibited by 10 and 100 pM adrenomedullin. Colforsin 65-74 adrenomedullin Homo sapiens 189-203 16933187-6 2006 The endothelial cell-conditioned medium together with angiotensin II and forskolin also potentiated aldosterone release by 1.5-fold and 2.6-fold, respectively, while preincubation of NCI-H295R cells for 24 h with endothelial cell-conditioned medium enhanced and sensitized the response of NCI-H295R to subsequent angiotensin II and forskolin stimuli by 2.5-fold and 2.2-fold, respectively. Colforsin 73-82 angiotensinogen Homo sapiens 313-327 16571352-9 2006 Using MEFs expressing only Gli2 or Gli3, we found that both cyclopamine and the PKA activator forskolin inhibited target gene induction mediated by Gli2 and Gli3. Colforsin 94-103 GLI-Kruppel family member GLI3 Mus musculus 35-39 16571352-9 2006 Using MEFs expressing only Gli2 or Gli3, we found that both cyclopamine and the PKA activator forskolin inhibited target gene induction mediated by Gli2 and Gli3. Colforsin 94-103 GLI-Kruppel family member GLI2 Mus musculus 148-152 16571352-9 2006 Using MEFs expressing only Gli2 or Gli3, we found that both cyclopamine and the PKA activator forskolin inhibited target gene induction mediated by Gli2 and Gli3. Colforsin 94-103 GLI-Kruppel family member GLI3 Mus musculus 157-161 16571352-9 2006 Using MEFs expressing only Gli2 or Gli3, we found that both cyclopamine and the PKA activator forskolin inhibited target gene induction mediated by Gli2 and Gli3. Colforsin 94-103 GLI-Kruppel family member GLI2 Mus musculus 27-31 16933187-6 2006 The endothelial cell-conditioned medium together with angiotensin II and forskolin also potentiated aldosterone release by 1.5-fold and 2.6-fold, respectively, while preincubation of NCI-H295R cells for 24 h with endothelial cell-conditioned medium enhanced and sensitized the response of NCI-H295R to subsequent angiotensin II and forskolin stimuli by 2.5-fold and 2.2-fold, respectively. Colforsin 332-341 angiotensinogen Homo sapiens 54-68 16595738-5 2006 Forskolin, which raised intracellular cAMP levels 340%, increased EphA5, EphB2, and Neuropilin1 expression, paralleling reported changes in the rat hippocampus after cocaine treatment. Colforsin 0-9 EPH receptor A5 Rattus norvegicus 66-71 16756988-10 2006 Endogenous RGS2 (but not RGS3-RGS5) expression was also up-regulated in cells with enhanced AC signaling (beta-adrenergic or forskolin stimulation). Colforsin 125-134 regulator of G protein signaling 2 Homo sapiens 11-15 16837612-5 2006 It was found that (1) in addition to the inhibitory effect on TX-elicited LHRH self-priming, E2 blocked P4 and adenylyl cyclase activator forskolin augmentation of LHRH-stimulated LH secretion, and (2) E2 did not affect the increasing action of TX on gonadotrope PR expression or pituitary cAMP content. Colforsin 138-147 gonadotropin releasing hormone 1 Rattus norvegicus 164-168 16837620-10 2006 In addition, it could be shown that thyroid glands of X. laevis tadpoles express Pax8 and Nkx2.1 mRNA in a developmentally regulated manner and that ex vivo treatment of thyroid glands with bTSH, forskolin, and cAMP analogs increased the expression of Pax8 and Nkx2.1 mRNA. Colforsin 196-205 NK2 homeobox 1 L homeolog Xenopus laevis 90-96 16837620-10 2006 In addition, it could be shown that thyroid glands of X. laevis tadpoles express Pax8 and Nkx2.1 mRNA in a developmentally regulated manner and that ex vivo treatment of thyroid glands with bTSH, forskolin, and cAMP analogs increased the expression of Pax8 and Nkx2.1 mRNA. Colforsin 196-205 paired box 8 L homeolog Xenopus laevis 252-256 16837620-10 2006 In addition, it could be shown that thyroid glands of X. laevis tadpoles express Pax8 and Nkx2.1 mRNA in a developmentally regulated manner and that ex vivo treatment of thyroid glands with bTSH, forskolin, and cAMP analogs increased the expression of Pax8 and Nkx2.1 mRNA. Colforsin 196-205 NK2 homeobox 1 L homeolog Xenopus laevis 261-267 16569752-4 2006 Application of 10 microM forskolin, an adenylyl cyclase stimulant, increased Cav3.2 channel activity by 40+/-4% over 30 min and negatively shifted the steady-state inactivation curve (V50=-61.4+/-0.2 versus -65.5+/-0.1 mV). Colforsin 25-34 caveolin 3, gene 2 S homeolog Xenopus laevis 77-83 16569752-7 2006 The augmentation of Cav3.2 channel activity by forskolin was strongly inhibited by preincubation with 20 microM N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89), and reversed by subsequent application of 500 nM protein kinase A inhibitor peptide. Colforsin 47-56 caveolin 3, gene 2 S homeolog Xenopus laevis 20-26 16595738-5 2006 Forskolin, which raised intracellular cAMP levels 340%, increased EphA5, EphB2, and Neuropilin1 expression, paralleling reported changes in the rat hippocampus after cocaine treatment. Colforsin 0-9 Eph receptor B2 Rattus norvegicus 73-78 16595738-5 2006 Forskolin, which raised intracellular cAMP levels 340%, increased EphA5, EphB2, and Neuropilin1 expression, paralleling reported changes in the rat hippocampus after cocaine treatment. Colforsin 0-9 neuropilin 1 Rattus norvegicus 84-95 16581183-8 2006 The nociceptin-induced respiratory depression was reversed by the activator of adenylyl cyclase, forskolin (5-25 microM) and the phosphodiesterase-4 blockers rolipram (0.1-1 microM) and RO-201724 (1-5 microM). Colforsin 97-106 prepronociceptin Homo sapiens 4-14 16618703-7 2006 Treatment with the AC activator forskolin or a cAMP analog increased cav-1 phosphorylation but decreased FAK Tyr-397 phosphorylation in a cAMP-dependent protein kinase-dependent manner. Colforsin 32-41 caveolin 1 Rattus norvegicus 69-74 16618703-7 2006 Treatment with the AC activator forskolin or a cAMP analog increased cav-1 phosphorylation but decreased FAK Tyr-397 phosphorylation in a cAMP-dependent protein kinase-dependent manner. Colforsin 32-41 protein tyrosine kinase 2 Rattus norvegicus 105-108 16510840-3 2006 We have characterized bovine PLA2G4A cDNA, and investigated its spatiotemporal regulation at the mRNA and protein levels in hCG-induced ovulatory follicles and in vitro, using forskolin-stimulated GC. Colforsin 176-185 phospholipase A2 group IVA Bos taurus 29-36 16436528-11 2006 In this regard, BMPs specifically reduced the STAR transcription, whereas the levels of CYP11A, HSD3B2, and CYP19 stimulated by forskolin as well as BtcAMP were not altered. Colforsin 128-137 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 88-94 16436528-11 2006 In this regard, BMPs specifically reduced the STAR transcription, whereas the levels of CYP11A, HSD3B2, and CYP19 stimulated by forskolin as well as BtcAMP were not altered. Colforsin 128-137 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Homo sapiens 96-102 16436528-11 2006 In this regard, BMPs specifically reduced the STAR transcription, whereas the levels of CYP11A, HSD3B2, and CYP19 stimulated by forskolin as well as BtcAMP were not altered. Colforsin 128-137 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 108-113 16631597-4 2006 Our studies found that c-Myb is expressed at a high level in K562 cells compared to primary erythroblasts, and that c-Myb expression is further increased following the treatment with forskolin, an adenylate cyclase activator. Colforsin 183-192 MYB proto-oncogene, transcription factor Homo sapiens 23-28 16631597-4 2006 Our studies found that c-Myb is expressed at a high level in K562 cells compared to primary erythroblasts, and that c-Myb expression is further increased following the treatment with forskolin, an adenylate cyclase activator. Colforsin 183-192 MYB proto-oncogene, transcription factor Homo sapiens 116-121 16631597-6 2006 Importantly, forskolin-induced erythroid differentiation in K562 cells, as determined by the expression of glycophorins and CD71, suggesting that high-level expression of c-Myb may not be sufficient to inhibit the differentiation of erythroid cells. Colforsin 13-22 transferrin receptor Homo sapiens 124-128 16631597-6 2006 Importantly, forskolin-induced erythroid differentiation in K562 cells, as determined by the expression of glycophorins and CD71, suggesting that high-level expression of c-Myb may not be sufficient to inhibit the differentiation of erythroid cells. Colforsin 13-22 MYB proto-oncogene, transcription factor Homo sapiens 171-176 16428343-4 2006 Forskolin (an activator of adenylyl cyclase that increases intracellular cAMP level) and 8-bromo-cAMP (a membrane-permeable cAMP analog) were used to stimulate NO release and activation of PKB and endothelial NO synthase (eNOS) in these blood vessels. Colforsin 0-9 nitric oxide synthase 3 Canis lupus familiaris 197-220 16428343-4 2006 Forskolin (an activator of adenylyl cyclase that increases intracellular cAMP level) and 8-bromo-cAMP (a membrane-permeable cAMP analog) were used to stimulate NO release and activation of PKB and endothelial NO synthase (eNOS) in these blood vessels. Colforsin 0-9 nitric oxide synthase 3 Canis lupus familiaris 222-226 16428343-6 2006 Western blot analysis showed that forskolin elicited a significant increase in eNOS phosphorylation (59 +/- 11%) at serine-1177 (a positively regulatory phosphorylation site for eNOS) and a significant increase in dephosphorylation (28 +/- 6%) at threonine-495 (a negatively regulatory phosphorylation site of eNOS) (P < 0.05 vs. control). Colforsin 34-43 nitric oxide synthase 3 Canis lupus familiaris 79-83 16428343-6 2006 Western blot analysis showed that forskolin elicited a significant increase in eNOS phosphorylation (59 +/- 11%) at serine-1177 (a positively regulatory phosphorylation site for eNOS) and a significant increase in dephosphorylation (28 +/- 6%) at threonine-495 (a negatively regulatory phosphorylation site of eNOS) (P < 0.05 vs. control). Colforsin 34-43 nitric oxide synthase 3 Canis lupus familiaris 178-182 16428343-6 2006 Western blot analysis showed that forskolin elicited a significant increase in eNOS phosphorylation (59 +/- 11%) at serine-1177 (a positively regulatory phosphorylation site for eNOS) and a significant increase in dephosphorylation (28 +/- 6%) at threonine-495 (a negatively regulatory phosphorylation site of eNOS) (P < 0.05 vs. control). Colforsin 34-43 nitric oxide synthase 3 Canis lupus familiaris 178-182 16510840-8 2006 Stimulation of cultured bovine GC with 10 microM of forskolin caused an increase in PLA2G4A mRNA and protein. Colforsin 52-61 phospholipase A2 group IVA Bos taurus 84-91 16644480-3 2006 In contrast, forskolin, an adenylate cyclase agonist, rather induced Cat K processing and maturation in osteoclast. Colforsin 13-22 cathepsin K Mus musculus 69-74 16582932-11 2006 PKC activation by PMA caused desensitization of mGluR4 as measured by forskolin-stimulated cAMP inhibition, whereas agonist activation had no effect on desensitization. Colforsin 70-79 glutamate receptor, ionotropic, AMPA4 (alpha 4) Mus musculus 48-54 16615994-6 2006 TNF-alpha suppressed IK when it was enhanced by isoproterenol, histamine or forskolin but not in the basal state or when IK was augmented by an internal application of cyclic AMP. Colforsin 76-85 tumor necrosis factor Cavia porcellus 0-9 16731796-7 2006 Moreover, increasing cAMP levels with forskolin or dibutyryl-cAMP was sufficient to stimulate TIMP-1 synthesis. Colforsin 38-47 TIMP metallopeptidase inhibitor 1 Homo sapiens 94-100 16900632-4 2006 RESULTS: The phosphorylation levels of tau at Tau-1, PHF-1, and pS214 epitopes were significantly elevated at 24, 48 and 72 h after single administration of Forskolin (P < 0.05). Colforsin 157-166 PHD finger protein 1 Rattus norvegicus 53-58 16551631-6 2006 Studies with PTHrP peptides 1-34 and 67-86, forskolin, and a PTH1 receptor (PTH1R)-specific siRNA showed that PTHrP regulates CDC2 and CDC25B, at least in part, via PTH1R in a cAMP-independent manner. Colforsin 44-53 parathyroid hormone like hormone Homo sapiens 110-115 16543407-4 2006 In cultured COCs, FSH/forskolin induced Areg mRNA within 0.5 h that peaked at 4 h, a process blocked by inhibitors of p38MAPK (SB203580), MAPK kinase (MEK) 1 (PD98059), and PTGS2 (NS398) but not protein kinase A (PKA) (KT5720). Colforsin 22-31 amphiregulin Mus musculus 40-44 16543407-4 2006 In cultured COCs, FSH/forskolin induced Areg mRNA within 0.5 h that peaked at 4 h, a process blocked by inhibitors of p38MAPK (SB203580), MAPK kinase (MEK) 1 (PD98059), and PTGS2 (NS398) but not protein kinase A (PKA) (KT5720). Colforsin 22-31 mitogen-activated protein kinase 14 Mus musculus 118-125 16543407-4 2006 In cultured COCs, FSH/forskolin induced Areg mRNA within 0.5 h that peaked at 4 h, a process blocked by inhibitors of p38MAPK (SB203580), MAPK kinase (MEK) 1 (PD98059), and PTGS2 (NS398) but not protein kinase A (PKA) (KT5720). Colforsin 22-31 mitogen-activated protein kinase kinase 1 Mus musculus 138-157 16543407-4 2006 In cultured COCs, FSH/forskolin induced Areg mRNA within 0.5 h that peaked at 4 h, a process blocked by inhibitors of p38MAPK (SB203580), MAPK kinase (MEK) 1 (PD98059), and PTGS2 (NS398) but not protein kinase A (PKA) (KT5720). Colforsin 22-31 prostaglandin-endoperoxide synthase 2 Mus musculus 173-178 16540462-3 2006 Here we show that EBI2 signals with constitutive activity through Galpha(i) as determined by a receptor-mediated inhibition of forskolin-induced cAMP production and an induction of the serum response element-driven transcriptional activity in a pertussis toxin-sensitive manner. Colforsin 127-136 G protein-coupled receptor 183 Homo sapiens 18-22 16557576-8 2006 Current clamp analysis demonstrated that voltage-dependent membrane resonance in response to a ZAP input current at depolarized holding potentials (approximately -50 mV) was specifically suppressed by forskolin or 5-HT. Colforsin 201-210 YLP motif containing 1 Rattus norvegicus 95-98 16574903-10 2006 After balloon injury of rat carotid arteries, local forskolin treatment significantly reduced FAKY397 phosphorylation, Skp2 expression, VSMC proliferation, and subsequent neointimal thickening. Colforsin 52-61 S-phase kinase associated protein 2 Rattus norvegicus 119-123 16492693-13 2006 8-Bromoadenosine cAMP and forskolin mimicked ACTH effects on the Angs. Colforsin 26-35 proopiomelanocortin Homo sapiens 45-49 16584897-9 2006 In addition, activation of protein kinase A (PKA) by forskolin significantly stimulated PGC proliferation, but PKA inhibitor H89 inhibited the proliferating effects induced by DAI and QUE. Colforsin 53-62 progastricsin Gallus gallus 88-91 16644694-3 2006 Although cholera toxin (an activator of Galphas) and forskolin (an activator of adenylyl cyclase) increased levels of intracellular cAMP in all cell lines, the GLP-1R agonist exendin-4 (Ex-4) increased cAMP only in CFPAC-1 cells. Colforsin 53-62 glucagon like peptide 1 receptor Homo sapiens 160-166 16303856-2 2006 The translocation of AQP2 required phosphorylation at serine 256, as the expression of AQP2/S256D was constitutively plasma membrane localized, whereas AQP2/S256A was refractory to forskolin stimulation. Colforsin 181-190 aquaporin 2 Homo sapiens 21-25 16303856-8 2006 Conversely, forskolin induced AQP2 translocation but not GLUT4. Colforsin 12-21 aquaporin 2 Homo sapiens 30-34 16303856-11 2006 To acquire insulin responsiveness following biosynthesis, GLUT4 undergoes a slow sorting step that requires 6-9 h. In contrast, AQP2 rapidly acquires forskolin responsiveness (3 h following biosynthesis) and directly enters the cAMP-regulated compartment without transiting the plasma membrane. Colforsin 150-159 solute carrier family 2 member 4 Homo sapiens 58-63 16303856-11 2006 To acquire insulin responsiveness following biosynthesis, GLUT4 undergoes a slow sorting step that requires 6-9 h. In contrast, AQP2 rapidly acquires forskolin responsiveness (3 h following biosynthesis) and directly enters the cAMP-regulated compartment without transiting the plasma membrane. Colforsin 150-159 aquaporin 2 Homo sapiens 128-132 16492402-7 2006 Forskolin induced CYP19 gene expression in both ovarian (3.7-fold) and testicular (2.6-fold) explants. Colforsin 0-9 cytochrome P450 family 19 subfamily A member 1 L homeolog Xenopus laevis 18-23 16483570-5 2006 Furthermore, the importance of CREB activation is strengthened by experiments with CREB mutants, treatment with forskolin, and in situ analysis of P-CREB status in cells transfected with Tax or its nonprotecting M47 mutant. Colforsin 112-121 cAMP responsive element binding protein 1 Homo sapiens 31-35 16477621-5 2006 The cannabinoid receptor agonists CP 55,940 and HU-210 produced concentration-dependent inhibition of forskolin-induced (3 microM) cyclic AMP production in the P19-derived neurons (29% at 1 microM CP 55,940 and 34% at 1 microM HU-210), which could be blocked by the CB1-selective receptor antagonist AM251, but not by the CB2-selective antagonist AM630. Colforsin 102-111 interleukin 23, alpha subunit p19 Mus musculus 160-163 16439612-8 2006 Exogenous iron (ferric ammonium citrate or ferricyanide) and forskolin increased the level of HO-1, which was inhibited by PKA inhibitor N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89). Colforsin 61-70 heme oxygenase 1 Mus musculus 94-98 16488513-10 2006 PC 314 and PC 315 inhibit forskolin-stimulated luciferase expression when CHO cells are co-transfected with NPFF2 receptor and CRE reporter vector. Colforsin 26-35 neuropeptide FF receptor 2 Homo sapiens 108-113 16490283-4 2006 FMRFamide also inhibited DARPP-32/Thr34 phosphorylation in the presence of forskolin. Colforsin 75-84 protein phosphatase 1, regulatory (inhibitor) subunit 1B Rattus norvegicus 25-33 16477621-5 2006 The cannabinoid receptor agonists CP 55,940 and HU-210 produced concentration-dependent inhibition of forskolin-induced (3 microM) cyclic AMP production in the P19-derived neurons (29% at 1 microM CP 55,940 and 34% at 1 microM HU-210), which could be blocked by the CB1-selective receptor antagonist AM251, but not by the CB2-selective antagonist AM630. Colforsin 102-111 cannabinoid receptor 1 (brain) Mus musculus 266-269 16477621-5 2006 The cannabinoid receptor agonists CP 55,940 and HU-210 produced concentration-dependent inhibition of forskolin-induced (3 microM) cyclic AMP production in the P19-derived neurons (29% at 1 microM CP 55,940 and 34% at 1 microM HU-210), which could be blocked by the CB1-selective receptor antagonist AM251, but not by the CB2-selective antagonist AM630. Colforsin 102-111 cannabinoid receptor 2 (macrophage) Mus musculus 322-325 16515544-2 2006 In the present study, forskolin, an adenylyl cyclase stimulator, significantly increased PPT mRNA levels in PPT-expressing RINm5F cells, an effect paralleled by an increase in PPT promoter-luciferase reporter construct activity. Colforsin 22-31 tachykinin, precursor 1 Rattus norvegicus 89-92 16641242-4 2006 At the cellular level, CREBGFP expression in the LC in vivo and in vitro had no significant effect on neuronal firing at baseline but enhanced the excitatory effect of forskolin (an activator of adenylyl cyclase) on these neurons, which suggests that the cAMP signaling pathway in these neurons was sensitized after CREB expression. Colforsin 168-177 cAMP responsive element binding protein 1 Rattus norvegicus 23-27 16470843-4 2006 When cAMP levels were increased, using either forskolin or a cell permeable analogue of cAMP, the heregulin-induced phosphorylation of ERK was converted from transient to sustained and the heregulin-induced phosphorylation of Akt was synergistically increased. Colforsin 46-55 mitogen-activated protein kinase 1 Homo sapiens 135-138 16470843-4 2006 When cAMP levels were increased, using either forskolin or a cell permeable analogue of cAMP, the heregulin-induced phosphorylation of ERK was converted from transient to sustained and the heregulin-induced phosphorylation of Akt was synergistically increased. Colforsin 46-55 AKT serine/threonine kinase 1 Homo sapiens 226-229 16377088-4 2006 Forskolin-induced cAMP formation was inhibited by [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DAMGO 1 microM), a specific MOR agonist. Colforsin 0-9 proenkephalin Rattus norvegicus 85-95 16377088-4 2006 Forskolin-induced cAMP formation was inhibited by [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DAMGO 1 microM), a specific MOR agonist. Colforsin 0-9 opioid receptor mu 1 Homo sapiens 125-128 16515544-4 2006 We found that the activation protein 1/cAMP response element (AP1/CRE) site centered at -196 relative to the transcription start site was important for basal and forskolin-induced PPT promoter activity. Colforsin 162-171 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 62-69 16515544-4 2006 We found that the activation protein 1/cAMP response element (AP1/CRE) site centered at -196 relative to the transcription start site was important for basal and forskolin-induced PPT promoter activity. Colforsin 162-171 tachykinin, precursor 1 Rattus norvegicus 180-183 16300797-6 2006 Forskolin mimicked the dual effects of prostaglandin E2 observed in the hEP2 cells. Colforsin 0-9 prostaglandin E receptor 2 Homo sapiens 72-76 16332977-7 2006 Confocal microscopy studies revealed that PAR2 and forskolin caused preferential release of a population of Weibel-Palade bodies (WPBs) consisting of only VWF. Colforsin 51-60 von Willebrand factor Homo sapiens 155-158 16394076-3 2006 In low-density cultures, paired recordings under the perforated patch demonstrated that 15-min forskolin treatment produced long-lasting potentiation of evoked excitatory postsynaptic currents (eEPSCs) mediated by the cAMP/PKA pathway. Colforsin 95-104 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 223-226 16515544-2 2006 In the present study, forskolin, an adenylyl cyclase stimulator, significantly increased PPT mRNA levels in PPT-expressing RINm5F cells, an effect paralleled by an increase in PPT promoter-luciferase reporter construct activity. Colforsin 22-31 tachykinin, precursor 1 Rattus norvegicus 108-111 16515544-2 2006 In the present study, forskolin, an adenylyl cyclase stimulator, significantly increased PPT mRNA levels in PPT-expressing RINm5F cells, an effect paralleled by an increase in PPT promoter-luciferase reporter construct activity. Colforsin 22-31 tachykinin, precursor 1 Rattus norvegicus 108-111 16515544-3 2006 The forskolin-induced stimulation of PPT transcription was protein kinase A dependent (PKA), as shown by blockade with the PKA inhibitor N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide. Colforsin 4-13 tachykinin, precursor 1 Rattus norvegicus 37-40 16205782-6 2006 Since CRH gene activity is most potently enhanced by cAMP/protein kinase A pathway, the effect of antipsychotics on the forskolin-induced CRH-CAT activity was determined. Colforsin 120-129 corticotropin releasing hormone Homo sapiens 6-9 16638588-8 2006 In primary amnion epithelial cell culture, AQP3 mRNA significantly increased at 2 hours following forskolin or SP-cAMP, remained elevated at 10 hours following forskolin, and returned to baseline levels by 20 hours following treatment. Colforsin 98-107 aquaporin 3 (Gill blood group) Homo sapiens 43-47 16638588-8 2006 In primary amnion epithelial cell culture, AQP3 mRNA significantly increased at 2 hours following forskolin or SP-cAMP, remained elevated at 10 hours following forskolin, and returned to baseline levels by 20 hours following treatment. Colforsin 160-169 aquaporin 3 (Gill blood group) Homo sapiens 43-47 16581769-4 2006 Consequently, NF-kappaB inhibition led to a decrease in forskolin-induced CREB phosphorylation. Colforsin 56-65 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 14-23 16581769-4 2006 Consequently, NF-kappaB inhibition led to a decrease in forskolin-induced CREB phosphorylation. Colforsin 56-65 cAMP responsive element binding protein 1 Mus musculus 74-78 16376953-5 2006 Subsequent experiments revealed that short-term (2 h) activation of the D2 dopamine receptor resulted in significantly enhanced forskolin-stimulated AC1 activity in the absence of Galpha(s), whereas sensitization of forskolin-stimulated AC5 activity appeared to require Galpha(s). Colforsin 128-137 dopamine receptor D2 Homo sapiens 72-92 16376953-5 2006 Subsequent experiments revealed that short-term (2 h) activation of the D2 dopamine receptor resulted in significantly enhanced forskolin-stimulated AC1 activity in the absence of Galpha(s), whereas sensitization of forskolin-stimulated AC5 activity appeared to require Galpha(s). Colforsin 128-137 adenylate cyclase 1 Homo sapiens 149-152 16376953-5 2006 Subsequent experiments revealed that short-term (2 h) activation of the D2 dopamine receptor resulted in significantly enhanced forskolin-stimulated AC1 activity in the absence of Galpha(s), whereas sensitization of forskolin-stimulated AC5 activity appeared to require Galpha(s). Colforsin 128-137 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 270-276 16376953-5 2006 Subsequent experiments revealed that short-term (2 h) activation of the D2 dopamine receptor resulted in significantly enhanced forskolin-stimulated AC1 activity in the absence of Galpha(s), whereas sensitization of forskolin-stimulated AC5 activity appeared to require Galpha(s). Colforsin 216-225 adenylate cyclase 5 Homo sapiens 237-240 16376953-5 2006 Subsequent experiments revealed that short-term (2 h) activation of the D2 dopamine receptor resulted in significantly enhanced forskolin-stimulated AC1 activity in the absence of Galpha(s), whereas sensitization of forskolin-stimulated AC5 activity appeared to require Galpha(s). Colforsin 216-225 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 270-276 16205782-6 2006 Since CRH gene activity is most potently enhanced by cAMP/protein kinase A pathway, the effect of antipsychotics on the forskolin-induced CRH-CAT activity was determined. Colforsin 120-129 corticotropin releasing hormone Homo sapiens 138-141 16434394-4 2006 Using human embryonic kidney 293 cells that are devoid of both endogenous PLM and NCX1, we first demonstrated that the exogenous NCX1 current (I(NaCa)) was increased by phorbol 12-myristate 13-acetate (PMA) but not by forskolin. Colforsin 218-227 solute carrier family 8 member A1 Homo sapiens 129-133 16472777-4 2006 Pre-incubation (>or=6h) of CF IB3-1 airway cells with >or=1mM ST7 or ST20 restored the ability of 100microM forskolin to stimulate an (125)I(-) efflux. Colforsin 114-123 suppression of tumorigenicity 7 Homo sapiens 68-71 16472777-4 2006 Pre-incubation (>or=6h) of CF IB3-1 airway cells with >or=1mM ST7 or ST20 restored the ability of 100microM forskolin to stimulate an (125)I(-) efflux. Colforsin 114-123 suppressor of tumorigenicity 20 Homo sapiens 75-79 16460680-3 2006 During a ligand fishing study for the orphan G-protein-coupled receptor 34 (GPR34), we found that lysoPS caused a dose-dependent inhibition of forskolin-stimulated cAMP accumulation in human GPR34-expressing Chinese hamster ovary (CHO/hGPR34) cells. Colforsin 143-152 G protein-coupled receptor 34 Homo sapiens 76-81 16460680-3 2006 During a ligand fishing study for the orphan G-protein-coupled receptor 34 (GPR34), we found that lysoPS caused a dose-dependent inhibition of forskolin-stimulated cAMP accumulation in human GPR34-expressing Chinese hamster ovary (CHO/hGPR34) cells. Colforsin 143-152 G protein-coupled receptor 34 Homo sapiens 191-196 16322355-5 2006 Intra-accumbal injections of forskolin, an adenylyl cyclase activator, stimulated the phosphorylation of CREB and increased both CART mRNA and peptide levels, an effect attenuated by inhibition of PKA with H89 [N-(2-[p-bromocinnamylamino]ethyl)-5-isoquinoline-sulfonamide hydrochloride] and adenosine-3",5"-cyclic monophosphorothioate, Rp-isomer (Rp-cAMPS). Colforsin 29-38 cAMP responsive element binding protein 1 Rattus norvegicus 105-109 16322355-5 2006 Intra-accumbal injections of forskolin, an adenylyl cyclase activator, stimulated the phosphorylation of CREB and increased both CART mRNA and peptide levels, an effect attenuated by inhibition of PKA with H89 [N-(2-[p-bromocinnamylamino]ethyl)-5-isoquinoline-sulfonamide hydrochloride] and adenosine-3",5"-cyclic monophosphorothioate, Rp-isomer (Rp-cAMPS). Colforsin 29-38 CART prepropeptide Rattus norvegicus 129-133 16322355-5 2006 Intra-accumbal injections of forskolin, an adenylyl cyclase activator, stimulated the phosphorylation of CREB and increased both CART mRNA and peptide levels, an effect attenuated by inhibition of PKA with H89 [N-(2-[p-bromocinnamylamino]ethyl)-5-isoquinoline-sulfonamide hydrochloride] and adenosine-3",5"-cyclic monophosphorothioate, Rp-isomer (Rp-cAMPS). Colforsin 29-38 calmodulin 2, pseudogene 1 Rattus norvegicus 350-355 16322355-7 2006 Under certain conditions, cocaine increases CART mRNA levels; thus, we examined the effects of cocaine on forskolin-induced CART mRNA expression in the rat nucleus accumbens. Colforsin 106-115 CART prepropeptide Rattus norvegicus 124-128 16322355-8 2006 Cocaine plus forskolin significantly increased CART mRNA over either of the drugs administered independently, suggesting that under conditions of heightened cAMP signaling, cocaine may impact CART gene expression. Colforsin 13-22 CART prepropeptide Rattus norvegicus 47-51 16322355-8 2006 Cocaine plus forskolin significantly increased CART mRNA over either of the drugs administered independently, suggesting that under conditions of heightened cAMP signaling, cocaine may impact CART gene expression. Colforsin 13-22 cathelicidin antimicrobial peptide Rattus norvegicus 157-161 16322355-8 2006 Cocaine plus forskolin significantly increased CART mRNA over either of the drugs administered independently, suggesting that under conditions of heightened cAMP signaling, cocaine may impact CART gene expression. Colforsin 13-22 CART prepropeptide Rattus norvegicus 192-196 16460680-3 2006 During a ligand fishing study for the orphan G-protein-coupled receptor 34 (GPR34), we found that lysoPS caused a dose-dependent inhibition of forskolin-stimulated cAMP accumulation in human GPR34-expressing Chinese hamster ovary (CHO/hGPR34) cells. Colforsin 143-152 G protein-coupled receptor 34 Homo sapiens 235-241 16434394-4 2006 Using human embryonic kidney 293 cells that are devoid of both endogenous PLM and NCX1, we first demonstrated that the exogenous NCX1 current (I(NaCa)) was increased by phorbol 12-myristate 13-acetate (PMA) but not by forskolin. Colforsin 218-227 nascent polypeptide associated complex subunit alpha Homo sapiens 145-149 16434394-5 2006 When co-expressed with NCX1, PLM resulted in: (i) decreases in I(NaCa), (ii) attenuation of the increase in I(NaCa) by PMA, and (iii) additional reduction in I(NaCa) in cells treated with forskolin. Colforsin 188-197 solute carrier family 8 member A1 Homo sapiens 23-27 16434394-5 2006 When co-expressed with NCX1, PLM resulted in: (i) decreases in I(NaCa), (ii) attenuation of the increase in I(NaCa) by PMA, and (iii) additional reduction in I(NaCa) in cells treated with forskolin. Colforsin 188-197 FXYD domain containing ion transport regulator 1 Homo sapiens 29-32 16434394-6 2006 Mutating serine 63 to alanine (S63A) preserved the sensitivity of PLM to forskolin in terms of suppression of I(NaCa), whereas mutating serine 68 to alanine (S68A) abolished the inhibitory effect of PLM on I(NaCa). Colforsin 73-82 FXYD domain containing ion transport regulator 1 Homo sapiens 66-69 16434394-6 2006 Mutating serine 63 to alanine (S63A) preserved the sensitivity of PLM to forskolin in terms of suppression of I(NaCa), whereas mutating serine 68 to alanine (S68A) abolished the inhibitory effect of PLM on I(NaCa). Colforsin 73-82 nascent polypeptide associated complex subunit alpha Homo sapiens 112-116 16219670-5 2006 In in vitro kinase assays and intact cells, we could show that cAMP-induced activation of CaMK, using the adenylate cyclase activator forskolin or the cAMP-analog Sp-5,6-DCI-cBIMPS (cBIMPS), was not mediated by PKA. Colforsin 134-143 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 90-94 16528103-7 2006 Correlatively, we found in placental cells that HDAC3 associates with the proximal GCMa-binding site (pGBS) in the syncytin promoter and dissociates from pGBS in the presence of forskolin, which stimulates the association of CBP and GCMa with pGBS. Colforsin 178-187 histone deacetylase 3 Homo sapiens 48-53 16528103-7 2006 Correlatively, we found in placental cells that HDAC3 associates with the proximal GCMa-binding site (pGBS) in the syncytin promoter and dissociates from pGBS in the presence of forskolin, which stimulates the association of CBP and GCMa with pGBS. Colforsin 178-187 CREB binding protein Homo sapiens 225-228 16528103-7 2006 Correlatively, we found in placental cells that HDAC3 associates with the proximal GCMa-binding site (pGBS) in the syncytin promoter and dissociates from pGBS in the presence of forskolin, which stimulates the association of CBP and GCMa with pGBS. Colforsin 178-187 glial cells missing transcription factor 1 Homo sapiens 233-237 16373334-6 2006 Known inducers of Mpz expression such as forskolin and insulin-like growth factor-1 also activate the element in an Egr2-dependent manner. Colforsin 41-50 myelin protein zero Homo sapiens 18-21 16373334-6 2006 Known inducers of Mpz expression such as forskolin and insulin-like growth factor-1 also activate the element in an Egr2-dependent manner. Colforsin 41-50 early growth response 2 Homo sapiens 116-120 16144963-7 2006 When mTAL suspensions were treated with dibutyryl cAMP (db-cAMP) or forskolin plus IBMX for 20 min, surface NKCC2 expression increased by 126 +/- 23 and 92 +/- 17% above basal, respectively (P < 0.03). Colforsin 68-77 solute carrier family 12 member 1 Rattus norvegicus 108-113 16339211-9 2006 NPY treatment reduced forskolin-stimulated cAMP accumulation only in PC3 cells and did not change intracellular calcium concentration in any PCa cell line. Colforsin 22-31 neuropeptide Y Homo sapiens 0-3 16444290-10 2006 The inhibition of the forskolin-induced production of cAMP through activation of the wt adenosine A1 receptor showed that LUF5831 had a submaximal effect (37+/-1%) in comparison to CPA (66+/-5%). Colforsin 22-31 adenosine A1 receptor Homo sapiens 88-109 16339211-9 2006 NPY treatment reduced forskolin-stimulated cAMP accumulation only in PC3 cells and did not change intracellular calcium concentration in any PCa cell line. Colforsin 22-31 proprotein convertase subtilisin/kexin type 1 Homo sapiens 69-72 16432888-7 2006 When the shark rectal gland CFTR channel was expressed in Xenopus oocytes and chloride conductance was measured by two-electrode voltage clamping, we found that 1 microM HgCl2 inhibited forskolin/IBMX conductance by 69.2 +/- 2.0%. Colforsin 186-195 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 28-32 16522728-4 2006 The stimulatory effect of GLP-1 and GIP was efficiently mimicked by the adenylate cyclase activator, forskolin, at 10 nM (approximately 90% increase) and was additive (approximately 170-250% increase) with the growth response to human growth hormone (hGH), indicating the use of distinct intracellular signalling pathways leading to mitosis by incretins and cytokines, respectively. Colforsin 101-110 glucagon Homo sapiens 26-31 16522728-4 2006 The stimulatory effect of GLP-1 and GIP was efficiently mimicked by the adenylate cyclase activator, forskolin, at 10 nM (approximately 90% increase) and was additive (approximately 170-250% increase) with the growth response to human growth hormone (hGH), indicating the use of distinct intracellular signalling pathways leading to mitosis by incretins and cytokines, respectively. Colforsin 101-110 gastric inhibitory polypeptide Homo sapiens 36-39 16522728-4 2006 The stimulatory effect of GLP-1 and GIP was efficiently mimicked by the adenylate cyclase activator, forskolin, at 10 nM (approximately 90% increase) and was additive (approximately 170-250% increase) with the growth response to human growth hormone (hGH), indicating the use of distinct intracellular signalling pathways leading to mitosis by incretins and cytokines, respectively. Colforsin 101-110 growth hormone 1 Homo sapiens 235-249 16522728-11 2006 Transient transfection of a cyclin D1 promoter-luciferase reporter construct into islet monolayer cells or INS-1 cells revealed approximately a 2-3 fold increase of transcriptional activity in response to GLP-1 and GIP, and a 4-7 fold increase in response to forskolin. Colforsin 259-268 cyclin D1 Rattus norvegicus 28-37 16522728-11 2006 Transient transfection of a cyclin D1 promoter-luciferase reporter construct into islet monolayer cells or INS-1 cells revealed approximately a 2-3 fold increase of transcriptional activity in response to GLP-1 and GIP, and a 4-7 fold increase in response to forskolin. Colforsin 259-268 insulin 1 Rattus norvegicus 107-112 16522741-5 2006 Instead, the cAMP-elevating agent forskolin induced cyclin D1 expression remarkably and this response was inhibited by pretreatment with H-89, a protein kinase A (PKA) inhibitor. Colforsin 34-43 cyclin D1 Rattus norvegicus 52-61 16522741-5 2006 Instead, the cAMP-elevating agent forskolin induced cyclin D1 expression remarkably and this response was inhibited by pretreatment with H-89, a protein kinase A (PKA) inhibitor. Colforsin 34-43 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 145-161 16522741-5 2006 Instead, the cAMP-elevating agent forskolin induced cyclin D1 expression remarkably and this response was inhibited by pretreatment with H-89, a protein kinase A (PKA) inhibitor. Colforsin 34-43 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 163-166 16338931-7 2006 Forskolin and dibutryl cyclic-AMP stimulate macrophage matrix metalloproteinase (MMP)-9 expression in a dose-dependent manner. Colforsin 0-9 matrix metallopeptidase 9 Mus musculus 55-87 16622778-0 2006 Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle. Colforsin 36-45 protein kinase C, gamma Rattus norvegicus 10-13 16622778-0 2006 Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle. Colforsin 36-45 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 68-72 16622778-5 2006 Forskolin (10 microM), an activator of adenylyl cyclase, which increases cAMP concentration, opened BKCa channels in single pulmonary arterial smooth muscle cells (PASMC) of the Sprague-Dawley rat. Colforsin 0-9 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 100-104 16622778-6 2006 The effect of forskolin was completely blocked by the PKC inhibitor Go 6983, which selectively blocks the alpha, beta, delta, gamma, and zeta PKC isozymes, and, by rottlerin, which selectively inhibits PKCdelta, and partially blocked by Go 6976, which selectively inhibits PKCalpha PKCbeta, and PKCmu. Colforsin 14-23 protein kinase C, gamma Rattus norvegicus 54-57 16622778-6 2006 The effect of forskolin was completely blocked by the PKC inhibitor Go 6983, which selectively blocks the alpha, beta, delta, gamma, and zeta PKC isozymes, and, by rottlerin, which selectively inhibits PKCdelta, and partially blocked by Go 6976, which selectively inhibits PKCalpha PKCbeta, and PKCmu. Colforsin 14-23 protein kinase C, gamma Rattus norvegicus 142-145 16622778-7 2006 These results indicate that specific PKC isozymes mediate forskolin-induced activation of BKCa channels in PASMC, which suggests that a signaling pathway involving PKC activation and cAMP exists in pulmonary arterial smooth muscle to open BKCa channels. Colforsin 58-67 protein kinase C, gamma Rattus norvegicus 37-40 16622778-7 2006 These results indicate that specific PKC isozymes mediate forskolin-induced activation of BKCa channels in PASMC, which suggests that a signaling pathway involving PKC activation and cAMP exists in pulmonary arterial smooth muscle to open BKCa channels. Colforsin 58-67 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 90-94 16622778-7 2006 These results indicate that specific PKC isozymes mediate forskolin-induced activation of BKCa channels in PASMC, which suggests that a signaling pathway involving PKC activation and cAMP exists in pulmonary arterial smooth muscle to open BKCa channels. Colforsin 58-67 protein kinase C, gamma Rattus norvegicus 164-167 16622778-7 2006 These results indicate that specific PKC isozymes mediate forskolin-induced activation of BKCa channels in PASMC, which suggests that a signaling pathway involving PKC activation and cAMP exists in pulmonary arterial smooth muscle to open BKCa channels. Colforsin 58-67 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 239-243 16302263-5 2006 RESULTS: The PKG activators, APT-cGMP (1 nM-100 microM) and PET-cGMP (1 nM-100 microM), and also SNP (1 nM-100 microM), forskolin (10 microM), diazoxide (100 microM) and nifedipine (3 microM) inhibited phenylephrine (20 microM)-induced contractions. Colforsin 120-129 protein kinase cGMP-dependent 1 Homo sapiens 13-16 16373340-0 2006 Forskolin-induced cell shrinkage and apical translocation of functional enhanced green fluorescent protein-human alphaENaC in H441 lung epithelial cell monolayers. Colforsin 0-9 sodium channel epithelial 1 subunit alpha Homo sapiens 113-122 16373340-5 2006 Stable expression of green fluorescent protein (GFP)-labeled human alphaENaC in H441 cells was used to investigate dynamic changes in the cellular localization of this protein in response to forskolin. Colforsin 191-200 sodium channel epithelial 1 subunit alpha Homo sapiens 67-76 16521184-10 2006 In contrast, the activation of p38 MAP kinase was inhibited only by a pretreatment with forskolin, and was unaffected by the other compounds. Colforsin 88-97 mitogen-activated protein kinase 14 Homo sapiens 31-45 16407766-1 2006 A series of nociceptin receptor ligands has been investigated in relationship to their capability to promote receptor endocytosis, desensitization (evaluated as inhibition of forskolin-stimulated cAMP production) and compensatory upregulation of adenylyl cyclase activity in CHO-K1 cells expressing the cloned human nociceptin receptor. Colforsin 175-184 nociceptin receptor Cricetulus griseus 12-31 16504084-11 2006 This result implied that the sensitivity of the IP3R to IP3 was reduced by FSK and this was supported by the reduced ability of IP3 to release Ca2+ in SMCs in the presence of FSK. Colforsin 75-78 inositol 1,4,5-trisphosphate receptor 1 Mus musculus 48-52 16504084-11 2006 This result implied that the sensitivity of the IP3R to IP3 was reduced by FSK and this was supported by the reduced ability of IP3 to release Ca2+ in SMCs in the presence of FSK. Colforsin 175-178 inositol 1,4,5-trisphosphate receptor 1 Mus musculus 48-52 16407769-3 2006 Treatment of dorsal root ganglia primary dispersed cultures with INGAP peptide led to the displacement of fluorescently labeled forskolin from adenylate cyclase, the cyclic AMP-generating enzyme that has been implicated in neuritogenesis. Colforsin 128-137 regenerating islet-derived 3 delta Mus musculus 65-70 16407769-4 2006 The addition of forskolin or dibutyryl cyclic AMP enhanced the effects of INGAP peptide on neurite outgrowth in dorsal root ganglia explant cultures. Colforsin 16-25 regenerating islet-derived 3 delta Mus musculus 74-79 16472591-2 2006 The present study was designed to examine the role of SLC26A6 in prostaglandin E(2) (PGE(2))-, forskolin-, and carbachol-induced duodenal HCO(3)(-) secretion. Colforsin 95-104 solute carrier family 26, member 6 Mus musculus 54-61 16144962-8 2006 A tetracycline-responsive promoter system was used to quantify the effect of forskolin on the half-lives of chimeric beta-globin-PEPCK (TbetaG-PCK) mRNAs. Colforsin 77-86 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 129-134 16144962-9 2006 The half-life of the labile betaG-PCK-1 mRNA was increased eightfold by addition of forskolin. Colforsin 84-93 phosphoenolpyruvate carboxykinase 1 Homo sapiens 34-39 16575120-11 2006 The rank order of efficacy was forskolin >NNP>CNP(1 microM)>GSNO. Colforsin 31-40 2',3'-cyclic nucleotide 3' phosphodiesterase Homo sapiens 52-55 16443828-5 2006 Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity. Colforsin 82-91 cAMP responsive element modulator Homo sapiens 22-26 16443828-5 2006 Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity. Colforsin 82-91 cAMP responsive element modulator Homo sapiens 54-58 16443828-5 2006 Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity. Colforsin 82-91 cAMP responsive element modulator Homo sapiens 54-58 16443828-5 2006 Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity. Colforsin 82-91 cAMP responsive element modulator Homo sapiens 54-58 16443828-5 2006 Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity. Colforsin 82-91 cAMP responsive element binding protein 1 Homo sapiens 187-191 16443828-5 2006 Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity. Colforsin 82-91 C-C motif chemokine ligand 4 Homo sapiens 248-257 16386234-9 2006 However, paralemmin also decreased basal, isoproterenol and forskolin-stimulated adenylate cyclase activity, suggesting a more general cellular function for paralemmin. Colforsin 60-69 paralemmin Homo sapiens 9-19 16405651-6 2006 The stimulatory effect of forskolin (an adenylate cyclase activator) on CORT secretion and accumulation of cAMP in ZFR cells was attenuated by the administration of IL-15. Colforsin 26-35 cortistatin Rattus norvegicus 72-76 16405651-6 2006 The stimulatory effect of forskolin (an adenylate cyclase activator) on CORT secretion and accumulation of cAMP in ZFR cells was attenuated by the administration of IL-15. Colforsin 26-35 interleukin 15 Rattus norvegicus 165-170 16610234-6 2006 Forskolin, an adenylate cyclase activator, also enhanced Runx2 and osterix transcription, and the stimulatory effects of PTH and forskolin were blocked by the pre-treatment of the cells with H-89, a protein kinase A (PKA) inhibitor. Colforsin 0-9 RUNX family transcription factor 2 Rattus norvegicus 57-62 16610234-6 2006 Forskolin, an adenylate cyclase activator, also enhanced Runx2 and osterix transcription, and the stimulatory effects of PTH and forskolin were blocked by the pre-treatment of the cells with H-89, a protein kinase A (PKA) inhibitor. Colforsin 0-9 Sp7 transcription factor Rattus norvegicus 67-74 16610234-6 2006 Forskolin, an adenylate cyclase activator, also enhanced Runx2 and osterix transcription, and the stimulatory effects of PTH and forskolin were blocked by the pre-treatment of the cells with H-89, a protein kinase A (PKA) inhibitor. Colforsin 0-9 parathyroid hormone Rattus norvegicus 121-124 16610234-6 2006 Forskolin, an adenylate cyclase activator, also enhanced Runx2 and osterix transcription, and the stimulatory effects of PTH and forskolin were blocked by the pre-treatment of the cells with H-89, a protein kinase A (PKA) inhibitor. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 199-215 16610234-6 2006 Forskolin, an adenylate cyclase activator, also enhanced Runx2 and osterix transcription, and the stimulatory effects of PTH and forskolin were blocked by the pre-treatment of the cells with H-89, a protein kinase A (PKA) inhibitor. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 217-220 16610234-6 2006 Forskolin, an adenylate cyclase activator, also enhanced Runx2 and osterix transcription, and the stimulatory effects of PTH and forskolin were blocked by the pre-treatment of the cells with H-89, a protein kinase A (PKA) inhibitor. Colforsin 129-138 RUNX family transcription factor 2 Rattus norvegicus 57-62 16610234-6 2006 Forskolin, an adenylate cyclase activator, also enhanced Runx2 and osterix transcription, and the stimulatory effects of PTH and forskolin were blocked by the pre-treatment of the cells with H-89, a protein kinase A (PKA) inhibitor. Colforsin 129-138 Sp7 transcription factor Rattus norvegicus 67-74 16610234-6 2006 Forskolin, an adenylate cyclase activator, also enhanced Runx2 and osterix transcription, and the stimulatory effects of PTH and forskolin were blocked by the pre-treatment of the cells with H-89, a protein kinase A (PKA) inhibitor. Colforsin 129-138 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 199-215 16610234-6 2006 Forskolin, an adenylate cyclase activator, also enhanced Runx2 and osterix transcription, and the stimulatory effects of PTH and forskolin were blocked by the pre-treatment of the cells with H-89, a protein kinase A (PKA) inhibitor. Colforsin 129-138 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 217-220 16316649-9 2006 Interestingly, the S arrest caused by prostanoid EP(3) receptor agonist seems to be cAMP dependent, at least in part, because forskolin treatment allowed S-arrested cells to progress through cell cycle and consequently growth. Colforsin 126-135 prostaglandin E receptor 3 (subtype EP3) Mus musculus 38-63 16449647-8 2006 Activation of the CREB transcriptional factor by forskolin dramatically promoted the expression of PEN-2 mRNA and protein, whereas the other components of the gamma-secretase complex remained unaffected. Colforsin 49-58 cAMP responsive element binding protein 1 Homo sapiens 18-22 16449647-8 2006 Activation of the CREB transcriptional factor by forskolin dramatically promoted the expression of PEN-2 mRNA and protein, whereas the other components of the gamma-secretase complex remained unaffected. Colforsin 49-58 presenilin enhancer, gamma-secretase subunit Homo sapiens 99-104 16141360-6 2006 In contrast, simultaneous transfection of Ngn2 and HB9 cDNA increased the expression of Isl1/2, a motoneuron marker, when the cells were maintained in medium supplemented with retinoic acid, forskolin, and sonic hedgehog. Colforsin 191-200 neurogenin 2 Homo sapiens 42-46 16141360-6 2006 In contrast, simultaneous transfection of Ngn2 and HB9 cDNA increased the expression of Isl1/2, a motoneuron marker, when the cells were maintained in medium supplemented with retinoic acid, forskolin, and sonic hedgehog. Colforsin 191-200 motor neuron and pancreas homeobox 1 Homo sapiens 51-54 16141360-6 2006 In contrast, simultaneous transfection of Ngn2 and HB9 cDNA increased the expression of Isl1/2, a motoneuron marker, when the cells were maintained in medium supplemented with retinoic acid, forskolin, and sonic hedgehog. Colforsin 191-200 ISL LIM homeobox 1 Homo sapiens 88-94 16301311-4 2006 The initial rate of L-lactate-dependent acidification was significantly inhibited by 5-10-min incubations with agonists of intracellular cAMP-dependent cell signaling pathways as follows: dibutyryl cAMP, forskolin, and isoproterenol. Colforsin 204-213 cathelicidin antimicrobial peptide Rattus norvegicus 137-141 16301311-6 2006 The effects of forskolin were completely reversed by the protein kinase A inhibitor H89, whereas H89 alone increased transport rates. Colforsin 15-24 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 57-73 16301311-7 2006 Cytoplasmic cAMP levels, measured by radioimmunoassay, were increased by forskolin or isoproterenol, and the effect of isoproterenol was inhibited by propranolol. Colforsin 73-82 cathelicidin antimicrobial peptide Rattus norvegicus 12-16 16272156-6 2006 Knockdown of CNrasGEF leads to increased dendrite extension and melanin production observed approximately 50 h after forskolin/isobutylmethylxanthine treatment, suggesting that CNrasGEF inhibits melanogenesis in the long term. Colforsin 117-126 Rap guanine nucleotide exchange factor (GEF) 2 Mus musculus 13-21 16272156-6 2006 Knockdown of CNrasGEF leads to increased dendrite extension and melanin production observed approximately 50 h after forskolin/isobutylmethylxanthine treatment, suggesting that CNrasGEF inhibits melanogenesis in the long term. Colforsin 117-126 Rap guanine nucleotide exchange factor (GEF) 2 Mus musculus 177-185 16226002-8 2006 The amiloride-sensitive Isc in NHMEE cells was much larger than in NHNE cells, whereas the forskolin-induced Isc, presumably mediated by CFTR, was significantly smaller in NHMEE cells. Colforsin 91-100 CF transmembrane conductance regulator Homo sapiens 137-141 16210360-0 2006 Stimulation of the novel estrogen receptor-alpha intronic TERP-1 promoter by estrogens, androgen, pituitary adenylate cyclase-activating peptide, and forskolin, and autoregulation by TERP-1 protein. Colforsin 150-159 peroxisomal trans-2-enoyl-CoA reductase Rattus norvegicus 58-62 16210360-3 2006 We found that 17beta-estradiol (E2), genistein, androgen, pituitary adenylate cyclase-activating peptide, and forskolin (FSK) all stimulated TERP-1 promoter activity, whereas progesterone had no effect. Colforsin 110-119 peroxisomal trans-2-enoyl-CoA reductase Rattus norvegicus 141-145 16210360-3 2006 We found that 17beta-estradiol (E2), genistein, androgen, pituitary adenylate cyclase-activating peptide, and forskolin (FSK) all stimulated TERP-1 promoter activity, whereas progesterone had no effect. Colforsin 121-124 peroxisomal trans-2-enoyl-CoA reductase Rattus norvegicus 141-145 16210360-12 2006 Thus, estrogens, androgen, and FSK can stimulate TERP-1 promoter activity, and increased TERP-1 expression modulates E2 stimulation of physiological promoters. Colforsin 31-34 peroxisomal trans-2-enoyl-CoA reductase Rattus norvegicus 49-53 16332507-1 2006 Vascular endothelial growth factor (VEGF), oncostatin M (OSM), and granulocyte chemotactic protein-2 (GCP-2/CXCL6) are up-regulated in U937 macrophages and peripheral blood macrophages exposed to LPS, beta-adrenergic receptor (beta2-AR) agonists (e.g. zilpaterol, and clenbuterol) and some other agents that induce intracellular cAMP (prostaglandin E2, forskolin, and butyryl cAMP). Colforsin 353-362 vascular endothelial growth factor A Homo sapiens 0-34 16210392-4 2006 Forskolin also had differential effects on cell viability (MTT reduction test) and proliferation (Ki67 immunostaining with MIB-1 monoclonal antibody), both decreasing in BeWo and increasing in JEG-3 cells. Colforsin 0-9 MIB E3 ubiquitin protein ligase 1 Homo sapiens 123-128 16332507-1 2006 Vascular endothelial growth factor (VEGF), oncostatin M (OSM), and granulocyte chemotactic protein-2 (GCP-2/CXCL6) are up-regulated in U937 macrophages and peripheral blood macrophages exposed to LPS, beta-adrenergic receptor (beta2-AR) agonists (e.g. zilpaterol, and clenbuterol) and some other agents that induce intracellular cAMP (prostaglandin E2, forskolin, and butyryl cAMP). Colforsin 353-362 C-X-C motif chemokine ligand 6 Homo sapiens 67-100 16332507-1 2006 Vascular endothelial growth factor (VEGF), oncostatin M (OSM), and granulocyte chemotactic protein-2 (GCP-2/CXCL6) are up-regulated in U937 macrophages and peripheral blood macrophages exposed to LPS, beta-adrenergic receptor (beta2-AR) agonists (e.g. zilpaterol, and clenbuterol) and some other agents that induce intracellular cAMP (prostaglandin E2, forskolin, and butyryl cAMP). Colforsin 353-362 C-X-C motif chemokine ligand 6 Homo sapiens 102-107 16332507-1 2006 Vascular endothelial growth factor (VEGF), oncostatin M (OSM), and granulocyte chemotactic protein-2 (GCP-2/CXCL6) are up-regulated in U937 macrophages and peripheral blood macrophages exposed to LPS, beta-adrenergic receptor (beta2-AR) agonists (e.g. zilpaterol, and clenbuterol) and some other agents that induce intracellular cAMP (prostaglandin E2, forskolin, and butyryl cAMP). Colforsin 353-362 C-X-C motif chemokine ligand 6 Homo sapiens 108-113 16123170-3 2005 TSH and forskolin, but not growth factors, rapidly inactivated RhoA, Rac1, and Cdc42, as assayed by detection of GTP-bound forms. Colforsin 8-17 ras homolog family member A Canis lupus familiaris 63-67 16451219-3 2006 Co-transfection of the inhibitory isoforms of CREM, ICER I and II and CREMbeta, and CRH promoter-luciferase constructs in 4B cells blunted basal and forskolin-stimulated CRH promoter activity, an effect which was abolished by mutation of the CRE of the CRH promoter. Colforsin 149-158 cAMP responsive element modulator Homo sapiens 46-50 16451219-3 2006 Co-transfection of the inhibitory isoforms of CREM, ICER I and II and CREMbeta, and CRH promoter-luciferase constructs in 4B cells blunted basal and forskolin-stimulated CRH promoter activity, an effect which was abolished by mutation of the CRE of the CRH promoter. Colforsin 149-158 cAMP responsive element modulator Homo sapiens 52-56 16451219-3 2006 Co-transfection of the inhibitory isoforms of CREM, ICER I and II and CREMbeta, and CRH promoter-luciferase constructs in 4B cells blunted basal and forskolin-stimulated CRH promoter activity, an effect which was abolished by mutation of the CRE of the CRH promoter. Colforsin 149-158 corticotropin releasing hormone Homo sapiens 84-87 16451219-3 2006 Co-transfection of the inhibitory isoforms of CREM, ICER I and II and CREMbeta, and CRH promoter-luciferase constructs in 4B cells blunted basal and forskolin-stimulated CRH promoter activity, an effect which was abolished by mutation of the CRE of the CRH promoter. Colforsin 149-158 corticotropin releasing hormone Homo sapiens 170-173 16451219-3 2006 Co-transfection of the inhibitory isoforms of CREM, ICER I and II and CREMbeta, and CRH promoter-luciferase constructs in 4B cells blunted basal and forskolin-stimulated CRH promoter activity, an effect which was abolished by mutation of the CRE of the CRH promoter. Colforsin 149-158 corticotropin releasing hormone Homo sapiens 170-173 16451219-4 2006 Western blot analyses and electromobility gel-shift and super-shift showed increases in endogenous ICER after 3 h of incubation with forskolin. Colforsin 133-142 cAMP responsive element modulator Homo sapiens 99-103 16451219-6 2006 The study shows that generation of ICER following prolonged stimulation with forskolin, or transfection of an ICER expression vector in hypothalamic cell lines expressing CRH, is associated with CREM binding to the CRH promoter and transcriptional repression. Colforsin 77-86 cAMP responsive element modulator Homo sapiens 35-39 16451219-6 2006 The study shows that generation of ICER following prolonged stimulation with forskolin, or transfection of an ICER expression vector in hypothalamic cell lines expressing CRH, is associated with CREM binding to the CRH promoter and transcriptional repression. Colforsin 77-86 cAMP responsive element modulator Homo sapiens 195-199 16451219-6 2006 The study shows that generation of ICER following prolonged stimulation with forskolin, or transfection of an ICER expression vector in hypothalamic cell lines expressing CRH, is associated with CREM binding to the CRH promoter and transcriptional repression. Colforsin 77-86 corticotropin releasing hormone Homo sapiens 215-218 16272151-3 2005 In this study, we have shown that p38 mitogen-activated protein kinase (p38) was activated in liver by fasting and in primary hepatocytes by glucagon or forskolin. Colforsin 153-162 mitogen-activated protein kinase 14 Mus musculus 34-37 16272151-3 2005 In this study, we have shown that p38 mitogen-activated protein kinase (p38) was activated in liver by fasting and in primary hepatocytes by glucagon or forskolin. Colforsin 153-162 mitogen-activated protein kinase 14 Mus musculus 72-75 17546509-3 2006 Application of forskolin induced a Cl(-) current; increased G (j) approximately 750%, 560%, 64% and 8% in Cx45, Cx40, Cx32 and Cx50, respectively; and decreased sensitivity to V (j ) gating, monitored by a change in the ratio between G (j) steady state and G (j) peak (G (j)SS/G (j)PK) at the pulse. Colforsin 15-24 gap junction protein gamma 1 L homeolog Xenopus laevis 106-110 17546509-3 2006 Application of forskolin induced a Cl(-) current; increased G (j) approximately 750%, 560%, 64% and 8% in Cx45, Cx40, Cx32 and Cx50, respectively; and decreased sensitivity to V (j ) gating, monitored by a change in the ratio between G (j) steady state and G (j) peak (G (j)SS/G (j)PK) at the pulse. Colforsin 15-24 gap junction protein alpha 5 L homeolog Xenopus laevis 112-116 17546509-3 2006 Application of forskolin induced a Cl(-) current; increased G (j) approximately 750%, 560%, 64% and 8% in Cx45, Cx40, Cx32 and Cx50, respectively; and decreased sensitivity to V (j ) gating, monitored by a change in the ratio between G (j) steady state and G (j) peak (G (j)SS/G (j)PK) at the pulse. Colforsin 15-24 gap junction protein beta 1 L homeolog Xenopus laevis 118-122 17546509-3 2006 Application of forskolin induced a Cl(-) current; increased G (j) approximately 750%, 560%, 64% and 8% in Cx45, Cx40, Cx32 and Cx50, respectively; and decreased sensitivity to V (j ) gating, monitored by a change in the ratio between G (j) steady state and G (j) peak (G (j)SS/G (j)PK) at the pulse. Colforsin 15-24 gap junction protein alpha 8 L homeolog Xenopus laevis 127-131 17546509-5 2006 COOH-terminus truncation reduced the forskolin effect on Cx40 (Cx40TR) but not on Cx32 (Cx32TR) channels. Colforsin 37-46 gap junction protein alpha 5 L homeolog Xenopus laevis 57-61 17546509-5 2006 COOH-terminus truncation reduced the forskolin effect on Cx40 (Cx40TR) but not on Cx32 (Cx32TR) channels. Colforsin 37-46 gap junction protein alpha 5 L homeolog Xenopus laevis 63-69 16123160-5 2005 Exposure of JEG-3 cells to forskolin, a mediator of the cAMP-dependent signaling pathway, provokes an immediate early response of CYP51, which has not been described before for any cholesterogenic gene. Colforsin 27-36 cytochrome P450 family 51 subfamily A member 1 Homo sapiens 130-135 16123170-3 2005 TSH and forskolin, but not growth factors, rapidly inactivated RhoA, Rac1, and Cdc42, as assayed by detection of GTP-bound forms. Colforsin 8-17 Rac family small GTPase 1 Canis lupus familiaris 69-73 16123170-3 2005 TSH and forskolin, but not growth factors, rapidly inactivated RhoA, Rac1, and Cdc42, as assayed by detection of GTP-bound forms. Colforsin 8-17 cell division control protein 42 homolog Canis lupus familiaris 79-84 16326837-5 2005 Our results indicate that ANP(1-28), CNP(1-22) and C-ANF inhibited cAMP synthesis stimulated by the physiological agonists histamine and 5-hydroxytryptamine or directly by forskolin. Colforsin 172-181 natriuretic peptide A Rattus norvegicus 53-56 16204368-5 2005 RESULTS: The treatment of adipocytes with forskolin increased mitochondrial copy number and the expression of genes involved in mitochondrial biogenesis (PPARgamma coactivator 1alpha and transcriptional factor A) and fatty acid oxidation (PPARalpha and medium-chain acyl-coenzyme A dehydrogenase). Colforsin 42-51 peroxisome proliferator activated receptor gamma Homo sapiens 154-163 16204368-5 2005 RESULTS: The treatment of adipocytes with forskolin increased mitochondrial copy number and the expression of genes involved in mitochondrial biogenesis (PPARgamma coactivator 1alpha and transcriptional factor A) and fatty acid oxidation (PPARalpha and medium-chain acyl-coenzyme A dehydrogenase). Colforsin 42-51 peroxisome proliferator activated receptor alpha Homo sapiens 239-248 16326838-7 2005 Abundance of COX-2 transcripts in thecal tissue incubated with forskolin depended on the progesterone/17beta-oestradiol ratio of the follicle fluid, i.e. the previous microenvironment in vivo. Colforsin 63-72 prostaglandin-endoperoxide synthase 2 Bos taurus 13-18 16242774-7 2005 Treatment of GalR1 transfected cells with the non-selective adenylyl cyclase activator forskolin influenced the rate of internalization when administered together with galanin (1-29). Colforsin 87-96 Galanin receptor type 1 Cricetulus griseus 13-18 16162821-4 2005 In rat adipocytes, forskolin-activated lipolysis was blocked by in vitro addition of a potent and selective HSL inhibitor or by prior treatment of the animals themselves. Colforsin 19-28 lipase E, hormone sensitive type Rattus norvegicus 108-111 16210354-6 2005 Immunoprecipitation, cell surface biotinylation, immunofluorescence, and functional assays confirmed the presence of deltaF508 CFTR at the cell surface in both cell lines after incubating the cells for 48 h at 27 degrees C. However, stimulators of wild-type CFTR such as forskolin, beta2-adrenergic or A2B-adenosine receptor agonists failed to activate rescued deltaF508 CFTR in CFBE41o- monolayers. Colforsin 271-280 CF transmembrane conductance regulator Homo sapiens 127-131 16210354-8 2005 Interestingly, rescued deltaF508 CFTR in HeLa cells could be efficiently stimulated with either forskolin or genistein to promote Cl- transport. Colforsin 96-105 CF transmembrane conductance regulator Homo sapiens 33-37 16242774-7 2005 Treatment of GalR1 transfected cells with the non-selective adenylyl cyclase activator forskolin influenced the rate of internalization when administered together with galanin (1-29). Colforsin 87-96 galanin peptides Cricetulus griseus 168-175 16421339-7 2005 Forskolin (elevates intracellular cAMP) stimulated IL-6 release from 3T3-L1 adipocytes (n = 3, p < 0.005), and H89, an inhibitor of cAMP-dependent protein kinase A (PKA), reduced TSH-stimulated IL-6 release by 66% (n = 3, p < 0.01), indicating a requirement for cAMP-dependent PKA. Colforsin 0-9 interleukin 6 Mus musculus 51-55 16263767-7 2005 Forskolin mimicked the repression of Cx36 by glucose. Colforsin 0-9 gap junction protein delta 2 Homo sapiens 37-41 16421339-7 2005 Forskolin (elevates intracellular cAMP) stimulated IL-6 release from 3T3-L1 adipocytes (n = 3, p < 0.005), and H89, an inhibitor of cAMP-dependent protein kinase A (PKA), reduced TSH-stimulated IL-6 release by 66% (n = 3, p < 0.01), indicating a requirement for cAMP-dependent PKA. Colforsin 0-9 interleukin 6 Mus musculus 197-201 16226369-4 2005 Addition of NaF, forskolin or sodium nitroprusside, activators of the inositol phosphates (IPs), cAMP and cGMP pathways, significantly increased their respective messengers in villous explants but failed to affect the hPL and hCG releases from syncytiotrophoblast. Colforsin 17-26 galectin 1 Homo sapiens 218-221 16226369-4 2005 Addition of NaF, forskolin or sodium nitroprusside, activators of the inositol phosphates (IPs), cAMP and cGMP pathways, significantly increased their respective messengers in villous explants but failed to affect the hPL and hCG releases from syncytiotrophoblast. Colforsin 17-26 hypertrichosis 2 (generalised, congenital) Homo sapiens 226-229 16172130-10 2005 We conclude that forskolin mediates cellular proliferation via cAMP-dependent activation of both PKA and Epac. Colforsin 17-26 Rap guanine nucleotide exchange factor 3 Homo sapiens 105-109 16293244-8 2005 Inhibition of forskolin-stimulated adenylyl cyclase showed a distinctly attenuating agonism for neuropeptide Y, with an activity similar to peptide YY below 1 nM, but considerably lower above 3 nM of the peptides. Colforsin 14-23 neuropeptide Y Homo sapiens 96-110 16153182-8 2005 Ser312 of PDE3A was phosphorylated in an H-89-sensitive response to forskolin, indicative of phosphorylation by PKA (cAMP-dependent protein kinase), but phosphorylation at this site did not stimulate 14-3-3 binding. Colforsin 68-77 phosphodiesterase 3A Homo sapiens 10-15 16319314-6 2005 Intrathecal coadministration of morphine with an adenylyl cyclase inhibitor (2",5"-dideoxyadenosine) or a protein kinase A inhibitor (H89) also significantly attenuated morphine-induced NR1 and PKCgamma expression, whereas intrathecal treatment with an adenylyl cyclase activator (forskolin) alone mimicked morphine-induced expression of GR, NR1, and PKCgamma. Colforsin 281-290 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 186-189 16172130-0 2005 Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. Colforsin 25-34 cAMP responsive element binding protein 1 Homo sapiens 99-138 16172130-0 2005 Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. Colforsin 25-34 cAMP responsive element binding protein 1 Homo sapiens 140-144 16172130-0 2005 Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. Colforsin 25-34 Rap guanine nucleotide exchange factor 3 Homo sapiens 150-155 16172130-0 2005 Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. Colforsin 25-34 RAP1A, member of RAS oncogene family Homo sapiens 156-160 16172130-1 2005 In this study, we have examined the role of two cAMP downstream effectors protein kinase A (PKA) and Epac, in forskolin-induced macrophage proliferation. Colforsin 110-119 Rap guanine nucleotide exchange factor 3 Homo sapiens 101-105 16172130-3 2005 Incubation of macrophages with forskolin triggered the activation of Akt, predominantly by phosphorylation of Ser-473, as measured by Western blotting and assay of its kinase activity. Colforsin 31-40 AKT serine/threonine kinase 1 Homo sapiens 69-72 16172130-5 2005 Incubation of macrophages with forskolin also increased Epac1 and Rap1.GTP. Colforsin 31-40 Rap guanine nucleotide exchange factor 3 Homo sapiens 56-61 16172130-5 2005 Incubation of macrophages with forskolin also increased Epac1 and Rap1.GTP. Colforsin 31-40 RAP1A, member of RAS oncogene family Homo sapiens 66-70 16172130-6 2005 Immunoprecipitation of Epac1 in forskolin-stimulated cells co-immunoprecipitated Rap1, p-Akt(Thr-308), and p-Akt(Ser-473). Colforsin 32-41 Rap guanine nucleotide exchange factor 3 Homo sapiens 23-28 16172130-6 2005 Immunoprecipitation of Epac1 in forskolin-stimulated cells co-immunoprecipitated Rap1, p-Akt(Thr-308), and p-Akt(Ser-473). Colforsin 32-41 RAP1A, member of RAS oncogene family Homo sapiens 81-85 16172130-6 2005 Immunoprecipitation of Epac1 in forskolin-stimulated cells co-immunoprecipitated Rap1, p-Akt(Thr-308), and p-Akt(Ser-473). Colforsin 32-41 AKT serine/threonine kinase 1 Homo sapiens 89-92 16172130-6 2005 Immunoprecipitation of Epac1 in forskolin-stimulated cells co-immunoprecipitated Rap1, p-Akt(Thr-308), and p-Akt(Ser-473). Colforsin 32-41 AKT serine/threonine kinase 1 Homo sapiens 109-112 16172130-7 2005 Silencing of CREB gene expression by RNA interference prior to forskolin treatment not only decreased CREB protein and its phosphorylation at Ser-133, but also phosphorylation of Akt at Ser-473, and Thr-308. Colforsin 63-72 cAMP responsive element binding protein 1 Homo sapiens 13-17 16263767-8 2005 Glucose or forskolin effects on Cx36 expression were not suppressed by the L-type Ca(2+)-channel blocker nifedipine but were fully blunted by the cAMP-dependent protein kinase (PKA) inhibitor H89. Colforsin 11-20 gap junction protein delta 2 Homo sapiens 32-36 16125054-6 2005 Activated p38 stimulated CREB-mediated transcription and potentiated the transcriptional strength of CREB provoked by forskolin. Colforsin 118-127 cAMP responsive element binding protein 1 Mus musculus 101-105 16246314-2 2005 Here, we report significant inhibition of forskolin-stimulated cAMP in dissected pontine tissue slices containing the PnOc incubated with the A1 receptor agonist, cyclohexaladenosine (10(-8) M). Colforsin 42-51 prepronociceptin Rattus norvegicus 118-122 16125054-3 2005 We analysed the pathways involved in CREB phosphorylation and activation in NIH 3T3 cells exposed to the cAMP elevating agent forskolin. Colforsin 126-135 cAMP responsive element binding protein 1 Mus musculus 37-41 16125054-4 2005 PKA represented the predominant pathway during the burst phase, while the mitogen-activated protein kinase p38 pathway became activated in a PKA-dependent fashion in forskolin treated cells. Colforsin 166-175 mitogen-activated protein kinase 14 Mus musculus 107-110 16125054-6 2005 Activated p38 stimulated CREB-mediated transcription and potentiated the transcriptional strength of CREB provoked by forskolin. Colforsin 118-127 mitogen-activated protein kinase 14 Mus musculus 10-13 15984930-6 2005 Forskolin increased PiC promoter activity via the CREB site. Colforsin 0-9 cAMP responsive element binding protein 1 Homo sapiens 50-54 16177565-3 2005 Forskolin, an activator of adenylate cyclase, inhibited fetal bovine serum (FBS)-stimulated BEL-7402 cell proliferation in a dose- and time-dependent manner, along with the inhibition of FBS-stimulated serine/threoine protein kinase Akt (also known as PKB) phosphorylation which is required for Akt activation and this effect was mimicked by 8-Br cAMP. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 233-236 16177565-3 2005 Forskolin, an activator of adenylate cyclase, inhibited fetal bovine serum (FBS)-stimulated BEL-7402 cell proliferation in a dose- and time-dependent manner, along with the inhibition of FBS-stimulated serine/threoine protein kinase Akt (also known as PKB) phosphorylation which is required for Akt activation and this effect was mimicked by 8-Br cAMP. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 252-255 16177565-3 2005 Forskolin, an activator of adenylate cyclase, inhibited fetal bovine serum (FBS)-stimulated BEL-7402 cell proliferation in a dose- and time-dependent manner, along with the inhibition of FBS-stimulated serine/threoine protein kinase Akt (also known as PKB) phosphorylation which is required for Akt activation and this effect was mimicked by 8-Br cAMP. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 295-298 16177565-3 2005 Forskolin, an activator of adenylate cyclase, inhibited fetal bovine serum (FBS)-stimulated BEL-7402 cell proliferation in a dose- and time-dependent manner, along with the inhibition of FBS-stimulated serine/threoine protein kinase Akt (also known as PKB) phosphorylation which is required for Akt activation and this effect was mimicked by 8-Br cAMP. Colforsin 0-9 cathelicidin antimicrobial peptide Homo sapiens 347-351 16177565-4 2005 Forskolin also inhibited Akt phosphorylation stimulated by other growth factors such as IGF-1, epidermal growth factor, and insulin. Colforsin 0-9 AKT serine/threonine kinase 1 Homo sapiens 25-28 16177565-4 2005 Forskolin also inhibited Akt phosphorylation stimulated by other growth factors such as IGF-1, epidermal growth factor, and insulin. Colforsin 0-9 insulin like growth factor 1 Homo sapiens 88-93 16177565-4 2005 Forskolin also inhibited Akt phosphorylation stimulated by other growth factors such as IGF-1, epidermal growth factor, and insulin. Colforsin 0-9 insulin Homo sapiens 124-131 16239525-0 2005 Effects of forskolin on Kupffer cell production of interleukin-10 and tumor necrosis factor alpha differ from those of endogenous adenylyl cyclase activators: possible role for adenylyl cyclase 9. Colforsin 11-20 interleukin 10 Rattus norvegicus 51-65 15920726-6 2005 Signals from P2Y12/13 receptors also cause beta1 integrin translocation to the membrane ruffle regions, but this redistribution was lost when the intracellular cyclic AMP (cAMP) was increased by forskolin or dibutyryl cAMP. Colforsin 195-204 purinergic receptor P2Y12 Homo sapiens 13-18 16125054-6 2005 Activated p38 stimulated CREB-mediated transcription and potentiated the transcriptional strength of CREB provoked by forskolin. Colforsin 118-127 cAMP responsive element binding protein 1 Mus musculus 25-29 16125054-8 2005 Our results suggest that forskolin-induced CREB phosphorylation and activation in NIH 3T3 cells is mediated directly by PKA and by a time-delayed PKA-dependent p38/MSK-1 pathway. Colforsin 25-34 cAMP responsive element binding protein 1 Mus musculus 43-47 16125054-8 2005 Our results suggest that forskolin-induced CREB phosphorylation and activation in NIH 3T3 cells is mediated directly by PKA and by a time-delayed PKA-dependent p38/MSK-1 pathway. Colforsin 25-34 mitogen-activated protein kinase 14 Mus musculus 160-163 16125054-8 2005 Our results suggest that forskolin-induced CREB phosphorylation and activation in NIH 3T3 cells is mediated directly by PKA and by a time-delayed PKA-dependent p38/MSK-1 pathway. Colforsin 25-34 ribosomal protein S6 kinase, polypeptide 5 Mus musculus 164-169 16099861-11 2005 In contrast, pituitary tissue from rats treated prenatally or neonatally with dexamethasone was unresponsive to the steroid, although, like control tissue, it responded readily to ANXA1, which readily inhibited forskolin-driven ACTH release. Colforsin 211-220 annexin A1 Rattus norvegicus 180-185 16239525-7 2005 Forskolin also reduced IL-10 mRNA and protein (P < or = 0.05), which was not observed with the other cAMP-inducing agents. Colforsin 0-9 interleukin 10 Rattus norvegicus 23-28 16079300-7 2005 Although expression of protein kinase A (PKA) and cAMP-stimulated PKA activity were similar in both the normal and diseased cell types, forskolin- and PGE(2)-stimulated cAMP response element-binding protein (CREB) phosphorylation was decreased in the diseased cell lines compared with the normal cells. Colforsin 136-145 cAMP responsive element binding protein 1 Homo sapiens 169-206 16088961-6 2005 Following stimulation by the adenylyl cyclase activator forskolin, TAF(II)105 in granulosa cells undergoes rapid and transient phosphorylation that is dependent upon protein kinase A (PKA). Colforsin 56-65 TATA-box binding protein associated factor 4b Homo sapiens 67-77 16079300-7 2005 Although expression of protein kinase A (PKA) and cAMP-stimulated PKA activity were similar in both the normal and diseased cell types, forskolin- and PGE(2)-stimulated cAMP response element-binding protein (CREB) phosphorylation was decreased in the diseased cell lines compared with the normal cells. Colforsin 136-145 cAMP responsive element binding protein 1 Homo sapiens 208-212 16155364-0 2005 Serine 68 phospholemman phosphorylation during forskolin-induced swine carotid artery relaxation. Colforsin 47-56 FXYD domain-containing ion transport regulator 7 Sus scrofa 10-23 16207298-3 2005 The UV-A light-evoked decline in pineal AANAT activity was blocked by cAMP protagonists (forskolin and dibutyryl-cAMP) and by inhibitors of the proteasomal degradation pathway (MG-132, proteasome inhibitor I, and lactacystin). Colforsin 89-98 aralkylamine N-acetyltransferase Gallus gallus 40-45 15928212-8 2005 CD suspensions from CD ET(A) KO mice had a 30-40% reduction in AVP- and forskolin-stimulated cAMP accumulation. Colforsin 72-81 endothelin receptor type A Mus musculus 23-28 16143415-8 2005 Moreover, adenylate cyclase (AC) activator forskolin (n = 7) was observed to evoke GP neurons an excitatory response, whereas the histamine-induced excitation was effectively reduced by H-89 (n = 9), a selective and potent inhibitor of protein kinase A (PK(A)). Colforsin 43-52 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 236-252 16044162-4 2005 Stimulation of cAMP production with pertussis and cholera toxin, or forskolin induced GEP in a PKA-independent fashion. Colforsin 68-77 granulin precursor Homo sapiens 86-89 16210642-7 2005 The secretagogues PMA, histamine, and forskolin triggered distinct dose and time-dependent responses of GROalpha release. Colforsin 38-47 C-X-C motif chemokine ligand 1 Homo sapiens 104-112 16085472-6 2005 The effects of VIP were potentiated by the cyclic AMP phosphodiesterase inhibitor rolipram and mimicked by forskolin, indicating the involvement of the cyclic AMP/protein kinase A pathway. Colforsin 107-116 vasoactive intestinal polypeptide Mus musculus 15-18 15994425-9 2005 PAPA-NONOate, H89, and nocodazole all reduced forskolin-stimulated CFTR trafficking. Colforsin 46-55 pappalysin 1 Homo sapiens 0-4 16056234-7 2005 The chloride-secretory response to forskolin was potentiated by prior basolateral addition of UTP and this potentiation was abolished in P2Y(4)-null mice. Colforsin 35-44 pyrimidinergic receptor P2Y, G-protein coupled, 4 Mus musculus 137-143 15994425-9 2005 PAPA-NONOate, H89, and nocodazole all reduced forskolin-stimulated CFTR trafficking. Colforsin 46-55 CF transmembrane conductance regulator Homo sapiens 67-71 15994425-11 2005 PAPA-NONOate reduced forskolin-stimulated increases in intracellular cAMP. Colforsin 21-30 pappalysin 1 Homo sapiens 0-4 16197510-6 2005 Forskolin (30 microm) caused an increase in glutamate release at MF synapses in slices from R6/2 mice and from Cplx2-/- mice that was not significantly different from that seen in control mice, indicating that the capacity for increased glutamate release is not diminished. Colforsin 0-9 complexin 2 Mus musculus 111-116 16002524-7 2005 PDE3 inhibitor prevented meiotic resumption of oocytes, whereas PDE4 inhibitor enhanced the ability of FSH or forskolin to activate MAPK in cumulus cells. Colforsin 110-119 phosphodiesterase 4A Homo sapiens 64-68 16093449-4 2005 In CD8 cells, BK pretreatment impaired forskolin-induced AQP2 translocation to the apical plasma membrane. Colforsin 39-48 kininogen 1 Homo sapiens 14-16 16093449-4 2005 In CD8 cells, BK pretreatment impaired forskolin-induced AQP2 translocation to the apical plasma membrane. Colforsin 39-48 aquaporin 2 Homo sapiens 57-61 16061485-5 2005 Our results show that Lot1 expression in CGC is cAMP-dependent, as treatments with either forskolin or PACAP-38 induced an increase in its expression at both the mRNA and protein levels. Colforsin 90-99 PLAG1 like zinc finger 1 Rattus norvegicus 22-26 16177189-2 2005 In this study, the dose-dependent effects of flavonoid compounds present in cocoa, or molecularly closely related compounds, were tested on forskolin-stimulated cystic fibrosis transmembrane conductance regulator (CFTR)-mediated Cl- secretion across T84 colonic epithelia in Ussing chambers. Colforsin 140-149 CF transmembrane conductance regulator Homo sapiens 214-218 16166624-5 2005 We found that forskolin and protein kinase A (PKA) enhances GCMa-mediated transcriptional activation. Colforsin 14-23 glial cells missing transcription factor 1 Homo sapiens 60-64 16120467-4 2005 In this study, we compared the ability of A23187 (Ca2+ ionophore) or forskolin (adenylate cyclase activator) to modulate the phosphorylation of Pyk2 in rat hippocampal slices. Colforsin 69-78 protein tyrosine kinase 2 beta Rattus norvegicus 144-148 16120467-8 2005 In contrast, application of forskolin reduced phosphorylated Pyk2 below basal levels, suggesting that cAMP inhibits Pyk2. Colforsin 28-37 protein tyrosine kinase 2 beta Rattus norvegicus 61-65 16120467-8 2005 In contrast, application of forskolin reduced phosphorylated Pyk2 below basal levels, suggesting that cAMP inhibits Pyk2. Colforsin 28-37 protein tyrosine kinase 2 beta Rattus norvegicus 116-120 16027156-5 2005 After activation of CFTR by 3-isobutyl-1-methylxanthine and forskolin or expression of CLC-0, the intracellular Cl- concentration was increased in Xenopus oocytes in the presence of a high bath Cl- concentration, which inhibited ENaC without changing surface expression of alpha beta gammaENaC. Colforsin 60-69 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) Xenopus laevis 20-24 15955620-5 2005 Treatment of BeWo cells with forskolin induced syncytialization and loss of monolayer integrity, but resulted in a marked increase in total leptin secretion, an effect further enhanced by co-treatment with dexamethasone. Colforsin 29-38 leptin Homo sapiens 140-146 16055445-2 2005 Elevation of cAMP and maximal cAMP-dependent protein kinase activation induced by 10 microm forskolin, 40 microm 3-isobutyl-1-methylxanthine caused a 50% reduction in myosin II regulatory light chain (RLC) phosphorylation and a 35% drop in isometric tension, but it did not inhibit thrombin-stimulated increases in RLC phosphorylation and isometric tension. Colforsin 92-101 coagulation factor II, thrombin Homo sapiens 282-290 16055445-7 2005 Activated cofilin correlates with increased F-actin severing activity in cell extracts from monolayers treated with forskolin/3-isobutyl-1-methylxanthine. Colforsin 116-125 cofilin 1 Homo sapiens 10-17 15961562-7 2005 The effects of hCG were mimicked by forskolin, indicating that they are cAMP dependent. Colforsin 36-45 hypertrichosis 2 (generalised, congenital) Homo sapiens 15-18 16043122-6 2005 CREB was activated by forskolin (10 microM), PMA (500 nM), and cyclical mechanical strain (1 Hz, 5% elongation) in fibroblasts. Colforsin 22-31 cAMP responsive element binding protein 1 Rattus norvegicus 0-4 15993752-10 2005 Using gel shift analysis, we found that forskolin activation of T-cells resulted in activation of AP1 sites; this increase in nuclear extract AP1 was significantly blocked by MEK1 inhibitor U0126. Colforsin 40-49 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 98-101 15993752-10 2005 Using gel shift analysis, we found that forskolin activation of T-cells resulted in activation of AP1 sites; this increase in nuclear extract AP1 was significantly blocked by MEK1 inhibitor U0126. Colforsin 40-49 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 142-145 15993752-10 2005 Using gel shift analysis, we found that forskolin activation of T-cells resulted in activation of AP1 sites; this increase in nuclear extract AP1 was significantly blocked by MEK1 inhibitor U0126. Colforsin 40-49 mitogen-activated protein kinase kinase 1 Homo sapiens 175-179 15871998-11 2005 Moreover, a sequence in the pre-S2 region is responsible for further transcriptional induction via CREB activators such as PKA and forskolin. Colforsin 131-140 cAMP responsive element binding protein 1 Homo sapiens 99-103 15707540-6 2005 These data were highly correlated with results obtained at recombinant human 5-HT1A receptors in determinations of G-protein activation and inhibition of forskolin-stimulated adenylyl cyclase. Colforsin 154-163 5-hydroxytryptamine receptor 1A Homo sapiens 77-83 16389727-6 2005 Exposure of FHRs to 4 weeks of 10% O2 (hypoxia) significantly attenuated the effect of both forskolin (n = 7) and CPT-cAMP (n = 14) on BKCa channel activity in PASMC. Colforsin 92-101 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 135-139 15828024-7 2005 Finally, elevation of intracellular cAMP induced by forskolin (50 microM) attenuated TGF-beta1-induced barrier dysfunction, MLC phosphorylation, and protected the MT peripheral network. Colforsin 52-61 transforming growth factor beta 1 Bos taurus 85-94 16083441-7 2005 Moreover, cells expressing C-terminal His-tagged CB1 were shown to inhibit forskolin-stimulated cyclic adenosine 3",5"-monophosphate (cAMP) production in a concentration-dependent manner in the presence of CP-55,940, confirming the expressed receptor"s functional characteristics. Colforsin 75-84 cannabinoid receptor 1 Homo sapiens 49-52 16038730-10 2005 The effects of DIDS and DPC on the forskolin-activated whole cell currents support the idea that both CFTR and ORCC are generating a significant fraction of these currents with DIDS inhibiting ORCC currents and DPC inhibiting CFTR currents when the blockers are added one after another to the extracellular side. Colforsin 35-44 CF transmembrane conductance regulator Homo sapiens 102-106 16038730-10 2005 The effects of DIDS and DPC on the forskolin-activated whole cell currents support the idea that both CFTR and ORCC are generating a significant fraction of these currents with DIDS inhibiting ORCC currents and DPC inhibiting CFTR currents when the blockers are added one after another to the extracellular side. Colforsin 35-44 CF transmembrane conductance regulator Homo sapiens 226-230 15927963-4 2005 The results show that forskolin stimulation and cPKA overexpression caused a marked and significant increase in USF-dependent DNA binding and PGHS-2 promoter activities (p < 0.05). Colforsin 22-31 prostaglandin-endoperoxide synthase 2 Bos taurus 142-148 16112393-4 2005 [125I]CPT-L1-SSA was internalized by SCLC cells at 37 degrees C but not at 4 degrees C. CPT-L1-SSA and CPT-L2-SSA inhibited in a dose-dependent manner the increase in adenylylcyclase activity caused by 25 microM forskolin. Colforsin 212-221 choline phosphotransferase 1 Homo sapiens 6-9 16112393-4 2005 [125I]CPT-L1-SSA was internalized by SCLC cells at 37 degrees C but not at 4 degrees C. CPT-L1-SSA and CPT-L2-SSA inhibited in a dose-dependent manner the increase in adenylylcyclase activity caused by 25 microM forskolin. Colforsin 212-221 choline phosphotransferase 1 Homo sapiens 88-91 16112393-4 2005 [125I]CPT-L1-SSA was internalized by SCLC cells at 37 degrees C but not at 4 degrees C. CPT-L1-SSA and CPT-L2-SSA inhibited in a dose-dependent manner the increase in adenylylcyclase activity caused by 25 microM forskolin. Colforsin 212-221 choline phosphotransferase 1 Homo sapiens 88-91 16009485-7 2005 Furthermore, signaling studies suggested that activation of Gs-protein-coupled pathways by forskolin and cholera toxin is sufficient to significantly downregulate ATGL mRNA. Colforsin 91-100 patatin like phospholipase domain containing 2 Homo sapiens 163-167 15970595-10 2005 VEGF protein release and Sp-1 reporter activity were increased by forskolin and isoproterenol, which increase cytosolic cAMP, and the cAMP analogue, 8-bromoadenosine-3",5"-cyclophosphoric acid. Colforsin 66-75 vascular endothelial growth factor A Homo sapiens 0-4 16056139-4 2005 Forskolin sequentially activated protein kinase A and B-regulation of alpha-fetoprotein (Raf), which led to phosphorylation of extracellular signal-regulated kinase. Colforsin 0-9 zinc fingers and homeoboxes 2 Homo sapiens 54-87 16056139-4 2005 Forskolin sequentially activated protein kinase A and B-regulation of alpha-fetoprotein (Raf), which led to phosphorylation of extracellular signal-regulated kinase. Colforsin 0-9 zinc fingers and homeoboxes 2 Homo sapiens 89-92 16006563-5 2005 Channel inhibition by agonists or by direct activators of PKC (phorbol dibutyrate) and PKA (forskolin) was disrupted not only by alanine or aspartate mutations at an identified PKA site (Ser-333) in the C terminus, but also at a more proximal regulatory site in the cytoplasmic C terminus (Ser-300); S333A and S300A mutations enhanced basal TREK-1 current, whereas S333D and S300D substitutions mimicked phosphorylation and strongly diminished currents. Colforsin 92-101 potassium two pore domain channel subfamily K member 2 Homo sapiens 341-347 15935514-4 2005 Interestingly, Pim-1 can synergize with forskolin-induced signaling pathways to stimulate also neuroendocrine functions of PC12 cells. Colforsin 40-49 Pim-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 15-20 16046477-2 2005 We report that forskolin stimulation was associated with a redistribution of moesin from intracellular sites to the cell cortex and with a concomitant enrichment of moesin in the particulate fraction in renal cells. Colforsin 15-24 moesin Homo sapiens 77-83 16046477-2 2005 We report that forskolin stimulation was associated with a redistribution of moesin from intracellular sites to the cell cortex and with a concomitant enrichment of moesin in the particulate fraction in renal cells. Colforsin 15-24 moesin Homo sapiens 165-171 16046477-3 2005 Introduction of a peptide reproducing a short sequence of moesin within the binding site for F-actin induced all the key effects of forskolin stimulation, including a decrease in F-actin, translocation of endogenous moesin, and AQP2 translocation. Colforsin 132-141 moesin Homo sapiens 58-64 16046477-3 2005 Introduction of a peptide reproducing a short sequence of moesin within the binding site for F-actin induced all the key effects of forskolin stimulation, including a decrease in F-actin, translocation of endogenous moesin, and AQP2 translocation. Colforsin 132-141 moesin Homo sapiens 216-222 16046477-3 2005 Introduction of a peptide reproducing a short sequence of moesin within the binding site for F-actin induced all the key effects of forskolin stimulation, including a decrease in F-actin, translocation of endogenous moesin, and AQP2 translocation. Colforsin 132-141 aquaporin 2 Homo sapiens 228-232 16046477-6 2005 Extraction with Triton X-100, which preserves cytoskeletal associated proteins, showed that forskolin stimulation or peptide introduction reduced the amount of phophorylated moesin, a molecular modification known to stabilize moesin in an active state. Colforsin 92-101 moesin Homo sapiens 174-180 16046477-6 2005 Extraction with Triton X-100, which preserves cytoskeletal associated proteins, showed that forskolin stimulation or peptide introduction reduced the amount of phophorylated moesin, a molecular modification known to stabilize moesin in an active state. Colforsin 92-101 moesin Homo sapiens 226-232 15927963-7 2005 Cotransfection studies with a USF2 mutant lacking N-terminal activation domains (U2Delta1-220) repressed forskolin-, cPKA-, and USF-dependent PGHS-2 promoter activities. Colforsin 105-114 upstream stimulatory factor 2 Bos taurus 30-34 15927963-7 2005 Cotransfection studies with a USF2 mutant lacking N-terminal activation domains (U2Delta1-220) repressed forskolin-, cPKA-, and USF-dependent PGHS-2 promoter activities. Colforsin 105-114 prostaglandin-endoperoxide synthase 2 Bos taurus 142-148 15927963-9 2005 Immunoprecipitation/Western blot analyses revealed an increase in the levels of phosphorylated USF1 and USF2 after forskolin treatment, whereas chromatin immunoprecipitation assays showed that binding of USF proteins to the endogenous PGHS-2 promoter was stimulated by forskolin. Colforsin 115-124 upstream transcription factor 1 Bos taurus 95-99 15927963-9 2005 Immunoprecipitation/Western blot analyses revealed an increase in the levels of phosphorylated USF1 and USF2 after forskolin treatment, whereas chromatin immunoprecipitation assays showed that binding of USF proteins to the endogenous PGHS-2 promoter was stimulated by forskolin. Colforsin 115-124 upstream stimulatory factor 2 Bos taurus 104-108 15927963-9 2005 Immunoprecipitation/Western blot analyses revealed an increase in the levels of phosphorylated USF1 and USF2 after forskolin treatment, whereas chromatin immunoprecipitation assays showed that binding of USF proteins to the endogenous PGHS-2 promoter was stimulated by forskolin. Colforsin 115-124 prostaglandin-endoperoxide synthase 2 Bos taurus 235-241 15927963-9 2005 Immunoprecipitation/Western blot analyses revealed an increase in the levels of phosphorylated USF1 and USF2 after forskolin treatment, whereas chromatin immunoprecipitation assays showed that binding of USF proteins to the endogenous PGHS-2 promoter was stimulated by forskolin. Colforsin 269-278 upstream transcription factor 1 Bos taurus 95-99 16080912-8 2005 When cells were pretreated with adenosine (100 microM; A2B agonist) or forskolin (10 microM), thrombin-induced phosphorylation was suppressed. Colforsin 71-80 coagulation factor II, thrombin Bos taurus 94-102 15937517-5 2005 Repeated exposure of cells expressing the rEP3alpha-R isoform to PGE(2) reduced the agonist induced inhibition of forskolin-stimulated cAMP-formation by 50% and led to internalization of the receptor to intracellular endocytotic vesicles. Colforsin 114-123 prostaglandin E receptor 3 Rattus norvegicus 42-51 15946941-7 2005 These sites are also phosphorylated when FLAG-tagged GRK1 and GRK7 are expressed in HEK-293 cells treated with forskolin to stimulate the endogenous production of cAMP and activation of PKA. Colforsin 111-120 G protein-coupled receptor kinase 1 Homo sapiens 53-57 15946941-7 2005 These sites are also phosphorylated when FLAG-tagged GRK1 and GRK7 are expressed in HEK-293 cells treated with forskolin to stimulate the endogenous production of cAMP and activation of PKA. Colforsin 111-120 G protein-coupled receptor kinase 7 Homo sapiens 62-66 16083514-10 2005 Theophylline, rolipram, etazolate, db-cAMP and forskolin suppressed both IL-13 mRNA expression (~25%, 2.73%, 8.12%, 5.28%, and 18.41%, respectively) and protein secretion (<10% production) in macrophages. Colforsin 47-56 interleukin 13 Homo sapiens 73-78 15946907-16 2005 Finally, we observed full suppression of SOST by the cAMP inducer forskolin, partial inhibition by ionomycin, and no effect with PMA, indicating that PTH action is mainly mediated via the cAMP/PKA pathway. Colforsin 66-75 sclerostin Rattus norvegicus 41-45 16075364-9 2005 Selective activation of cAMP-PKA signaling with, 10 microM forskolin (FSK) and PKC signaling with 1 microM phorbol 12-myristate 13-acetate (PMA) significantly increased RAMP3 mRNA levels, whereas 1 microM ionomycin (a calcium ionophore) had no effect. Colforsin 59-68 receptor (calcitonin) activity modifying protein 3 Mus musculus 169-174 16075364-9 2005 Selective activation of cAMP-PKA signaling with, 10 microM forskolin (FSK) and PKC signaling with 1 microM phorbol 12-myristate 13-acetate (PMA) significantly increased RAMP3 mRNA levels, whereas 1 microM ionomycin (a calcium ionophore) had no effect. Colforsin 70-73 receptor (calcitonin) activity modifying protein 3 Mus musculus 169-174 16075364-10 2005 Pretreatment with 30 microM H89, a PKA inhibitor, significantly blocked PTH- and FSK-induced RAMP3 mRNA levels. Colforsin 81-84 receptor (calcitonin) activity modifying protein 3 Mus musculus 93-98 15849738-4 2005 PTH and forskolin dose dependently increased a approximately 52 kDa band in whole cell lysates that was detected by both C- and N-terminal directed RANKL antibodies. Colforsin 8-17 TNF superfamily member 11 Rattus norvegicus 148-153 16083715-5 2005 RESULTS: EGF pretreatment of normal colonic mucosa inhibited ion transport responses to carbachol and forskolin but potentiated the reduced ion transport responses seen in dextran sulfate sodium (DSS)-treated and mdr1a knockout mouse colon. Colforsin 102-111 epidermal growth factor Mus musculus 9-12 15706595-7 2005 Expression of activated Rac1 prevents forskolin-induced cAMP stellation, suggesting that cAMP affects cell morphology by inhibiting Rac function. Colforsin 38-47 Rac family small GTPase 1 Homo sapiens 24-28 15706595-7 2005 Expression of activated Rac1 prevents forskolin-induced cAMP stellation, suggesting that cAMP affects cell morphology by inhibiting Rac function. Colforsin 38-47 Rac family small GTPase 1 Homo sapiens 24-27 15706595-8 2005 Consistent with this, treatment with forskolin inhibits agonist-stimulated Rac activation in VSMCs. Colforsin 37-46 Rac family small GTPase 1 Homo sapiens 75-78 16001968-5 2005 Reporter gene assay showed that DOP-3 attenuates forskolin-stimulated cAMP formation in response to dopamine stimulation, whereas DOP-3nf does not. Colforsin 49-58 Dopamine receptor 3 Caenorhabditis elegans 32-37 15849738-3 2005 We have determined the effects of PTH, the adenylate cyclase stimulator forskolin, and calcitriol, alone and in combination, on endogenous RANKL protein expression in UMR-106 rat osteoblastic osteosarcoma cells by Western blotting and enzyme immunoassay (EIA). Colforsin 72-81 TNF superfamily member 11 Rattus norvegicus 139-144 16001968-6 2005 When DOP-3 was coexpressed with DOP-3nf, the ability to inhibit forskolin-stimulated cAMP formation was reduced. Colforsin 64-73 Dopamine receptor 3 Caenorhabditis elegans 5-10 16015685-9 2005 The TMP-elicited I(SC) as well as forskolin- or IBMX-induced I(SC) were abolished in mice with homozygous mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) presenting defective CFTR functions and secretions. Colforsin 34-43 cystic fibrosis transmembrane conductance regulator Mus musculus 122-173 15882914-11 2005 Pretreatment of transfected cells with the PKA blocker, H-89, completely prevented both PACAP- and forskolin-induced increases in CRH promoter activity. Colforsin 99-108 corticotropin releasing hormone Homo sapiens 130-133 16015685-9 2005 The TMP-elicited I(SC) as well as forskolin- or IBMX-induced I(SC) were abolished in mice with homozygous mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) presenting defective CFTR functions and secretions. Colforsin 34-43 cystic fibrosis transmembrane conductance regulator Mus musculus 175-179 15994754-8 2005 Treatment of FRTL-5 cells with SB203580 decreased total and cyclin E-associated Cdk2 kinase activity stimulated with forskolin and insulin. Colforsin 117-126 cyclin E1 Rattus norvegicus 60-68 15741241-5 2005 The addition of phorbol 12-myristate,13-acetate (PMA) and forskolin to hepatocytes increased Hal mRNA concentration by 100 and 40%, respectively. Colforsin 58-67 histidine ammonia lyase Rattus norvegicus 93-96 15994754-8 2005 Treatment of FRTL-5 cells with SB203580 decreased total and cyclin E-associated Cdk2 kinase activity stimulated with forskolin and insulin. Colforsin 117-126 cyclin dependent kinase 2 Rattus norvegicus 80-84 15914334-11 2005 DbcAMP and forskolin augmented the Ca(2+)-PKC-induced STAT1 phosphorylation thus suggesting a convergent crosstalk between the two histamine receptor signaling pathways, PKA and PKC. Colforsin 11-20 signal transducer and activator of transcription 1 Mus musculus 54-59 16002533-6 2005 In the H295R adrenal tumour cell line, SF-1 and nur77 transcripts were increased in cells in the presence of forskolin, whereas nur77 mRNA was also induced with angiotensin II (AII). Colforsin 109-118 splicing factor 1 Homo sapiens 39-43 16002533-6 2005 In the H295R adrenal tumour cell line, SF-1 and nur77 transcripts were increased in cells in the presence of forskolin, whereas nur77 mRNA was also induced with angiotensin II (AII). Colforsin 109-118 nuclear receptor subfamily 4 group A member 1 Homo sapiens 48-53 16002533-9 2005 The corepressor SMRT interacted with SF-1 in the presence of AII and with nur77 in cells treated with forskolin. Colforsin 102-111 nuclear receptor subfamily 4 group A member 1 Homo sapiens 74-79 16002533-7 2005 The coactivator SRC-1 mRNA was increased in the presence of both forskolin and AII. Colforsin 65-74 nuclear receptor coactivator 1 Homo sapiens 16-21 16002547-9 2005 Furthermore, Cdx-2 and insulin gene expressions in the wild-type RIN-1056A cells were stimulated by forskolin treatment, and forskolin-mediated activation on insulin gene expression was attenuated in the absence of Cdx-2. Colforsin 100-109 caudal type homeo box 2 Rattus norvegicus 13-18 16002547-9 2005 Furthermore, Cdx-2 and insulin gene expressions in the wild-type RIN-1056A cells were stimulated by forskolin treatment, and forskolin-mediated activation on insulin gene expression was attenuated in the absence of Cdx-2. Colforsin 125-134 caudal type homeo box 2 Rattus norvegicus 13-18 16002533-8 2005 Forskolin induced recruitment of SRC-1 to the SF-1 response element and induced SRC-1-SF-1 interactions, whereas AII increased recruitment of SRC-1 to the nur77 response element and induced SRC-1-nur77 interactions. Colforsin 0-9 nuclear receptor coactivator 1 Homo sapiens 33-38 16002533-8 2005 Forskolin induced recruitment of SRC-1 to the SF-1 response element and induced SRC-1-SF-1 interactions, whereas AII increased recruitment of SRC-1 to the nur77 response element and induced SRC-1-nur77 interactions. Colforsin 0-9 nuclear receptor coactivator 1 Homo sapiens 80-85 16002533-8 2005 Forskolin induced recruitment of SRC-1 to the SF-1 response element and induced SRC-1-SF-1 interactions, whereas AII increased recruitment of SRC-1 to the nur77 response element and induced SRC-1-nur77 interactions. Colforsin 0-9 splicing factor 1 Homo sapiens 86-90 16002533-8 2005 Forskolin induced recruitment of SRC-1 to the SF-1 response element and induced SRC-1-SF-1 interactions, whereas AII increased recruitment of SRC-1 to the nur77 response element and induced SRC-1-nur77 interactions. Colforsin 0-9 nuclear receptor coactivator 1 Homo sapiens 80-85 16002533-8 2005 Forskolin induced recruitment of SRC-1 to the SF-1 response element and induced SRC-1-SF-1 interactions, whereas AII increased recruitment of SRC-1 to the nur77 response element and induced SRC-1-nur77 interactions. Colforsin 0-9 nuclear receptor coactivator 1 Homo sapiens 80-85 16002533-9 2005 The corepressor SMRT interacted with SF-1 in the presence of AII and with nur77 in cells treated with forskolin. Colforsin 102-111 nuclear receptor corepressor 2 Homo sapiens 16-20 15950778-4 2005 We found that treatment of CGNs with HK, the cAMP-elevating agent forskolin, IGF-1, and lithium resulted in phosphorylation of GSK3beta at serine-9 and thus its inactivation. Colforsin 66-75 glycogen synthase kinase 3 beta Rattus norvegicus 127-135 15985698-4 2005 Activation of calcium-stimulated adenylyl cyclase subtype 1 (AC1) is essential for the induction of LTP in ACC neurons, while AC8 subunit partially contributes to forskolin-induced potentiation. Colforsin 163-172 adenylate cyclase 8 Homo sapiens 126-129 15718291-2 2005 Forskolin induced IGFBP-3 reporter activity in transiently transfected granulosa cells. Colforsin 0-9 insulin-like growth factor-binding protein 3 Sus scrofa 18-25 15944267-8 2005 CRH-stimulated VEGF production was mediated through activation of adenylate cyclase and increased cAMP, as evidenced by the fact that the effect of CRH was mimicked by the direct adenylate cyclase activator forskolin and the cell-permeable cAMP analog 8-bromo-cAMP, whereas it was abolished by the adenylate cyclase inhibitor SQ22536. Colforsin 207-216 corticotropin releasing hormone Homo sapiens 0-3 15944267-8 2005 CRH-stimulated VEGF production was mediated through activation of adenylate cyclase and increased cAMP, as evidenced by the fact that the effect of CRH was mimicked by the direct adenylate cyclase activator forskolin and the cell-permeable cAMP analog 8-bromo-cAMP, whereas it was abolished by the adenylate cyclase inhibitor SQ22536. Colforsin 207-216 vascular endothelial growth factor A Homo sapiens 15-19 15944267-8 2005 CRH-stimulated VEGF production was mediated through activation of adenylate cyclase and increased cAMP, as evidenced by the fact that the effect of CRH was mimicked by the direct adenylate cyclase activator forskolin and the cell-permeable cAMP analog 8-bromo-cAMP, whereas it was abolished by the adenylate cyclase inhibitor SQ22536. Colforsin 207-216 corticotropin releasing hormone Homo sapiens 148-151 15950778-5 2005 Furthermore, pharmacological inhibition of core components in the survival signaling cascades initiated by HK, forskolin, IGF-1, and lithium causes apoptosis and activation of GSK3beta accompanies this death. Colforsin 111-120 glycogen synthase kinase 3 beta Rattus norvegicus 176-184 15941390-7 2005 Phorbol myristate acetate and/or forskolin increased the amount of beta-galactosidase positive cells up to fivefold. Colforsin 33-42 galactosidase, beta 1 Rattus norvegicus 67-85 15949713-12 2005 Since adenylate cyclase activator forskolin prevents the increase in NE-induced IL-1beta and IL-10, the up-regulatory effect of NE on those cytokines appears to be mediated, at least in part, by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels. Colforsin 34-43 interleukin 1 beta Rattus norvegicus 80-88 15949713-12 2005 Since adenylate cyclase activator forskolin prevents the increase in NE-induced IL-1beta and IL-10, the up-regulatory effect of NE on those cytokines appears to be mediated, at least in part, by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels. Colforsin 34-43 interleukin 10 Rattus norvegicus 93-98 15731358-4 2005 Repression of PRAP/17betaHSD7 expression and promoter activity by human chorionic gonadotropin/forskolin was localized to a -52-bp proximal segment of the promoter. Colforsin 95-104 RNA, U1 small nuclear 4 Homo sapiens 14-29 15914115-7 2005 Furthermore, prior treatment of cells with RGS2 antibody, that completely attenuated Ang II-induced expression of RGS2, prevented the GTPgammaS-induced attenuation of FSK-stimulated adenylyl cyclase activity. Colforsin 167-170 regulator of G protein signaling 2 Homo sapiens 43-47 15914115-7 2005 Furthermore, prior treatment of cells with RGS2 antibody, that completely attenuated Ang II-induced expression of RGS2, prevented the GTPgammaS-induced attenuation of FSK-stimulated adenylyl cyclase activity. Colforsin 167-170 angiotensinogen Homo sapiens 85-91 15914115-7 2005 Furthermore, prior treatment of cells with RGS2 antibody, that completely attenuated Ang II-induced expression of RGS2, prevented the GTPgammaS-induced attenuation of FSK-stimulated adenylyl cyclase activity. Colforsin 167-170 regulator of G protein signaling 2 Homo sapiens 114-118 15930160-8 2005 Furthermore, activation of G(s)-protein-coupled pathways by forskolin and cholera toxin was sufficient to significantly downregulate visfatin mRNA. Colforsin 60-69 nicotinamide phosphoribosyltransferase Homo sapiens 133-141 15943809-6 2005 We show here that forskolin and cAMP upregulate Cdx-2 expression in proglucagon producing cells, but not in colon cancer cells and primary intestinal cell cultures. Colforsin 18-27 caudal type homeobox 2 Mus musculus 48-53 15943809-9 2005 Furthermore, forskolin activated ERK1/2 phosphorylation in the endocrine cells, and attenuation of ERK1/2 phosphorylation by its inhibitor is associated with attenuated Cdx-2 expression. Colforsin 13-22 mitogen-activated protein kinase 3 Mus musculus 33-39 15943809-9 2005 Furthermore, forskolin activated ERK1/2 phosphorylation in the endocrine cells, and attenuation of ERK1/2 phosphorylation by its inhibitor is associated with attenuated Cdx-2 expression. Colforsin 13-22 caudal type homeobox 2 Mus musculus 169-174 15974932-7 2005 DU124183 left-shifted the agonist conc.-response curve for inhibition of forskolin-stimulated cAMP accumulation in intact cells expressing the human A(3)AR with up to 30% potentiation of the maximal efficacy. Colforsin 73-82 adenosine A3 receptor Homo sapiens 149-155 15948687-10 2005 Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells. Colforsin 35-44 interleukin 1 alpha Homo sapiens 102-111 15948687-10 2005 Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells. Colforsin 35-44 matrix metallopeptidase 3 Homo sapiens 123-128 29539150-10 2005 Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells. Colforsin 35-44 interleukin 1 alpha Homo sapiens 102-111 29539150-10 2005 Dibutyryl cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, significantly inhibited IL-1alpha-stimulated MMP-3 production in PDL cells. Colforsin 35-44 matrix metallopeptidase 3 Homo sapiens 123-128 15814298-5 2005 Forskolin stimulated the promoter activity of the HSD17B5 gene through this Sp1/Sp3 binding site. Colforsin 0-9 aldo-keto reductase family 1 member C3 Homo sapiens 50-57 15845376-4 2005 Furthermore, in the V-1 transfectants, the amount of CapZ which physically associated with V-1 was steeply reduced at 2h after treatment with forskolin, but was thereafter increased to reach its initial level at 12h after forskolin-treatment. Colforsin 142-151 immunoglobulin kappa variable 1-5 Homo sapiens 20-23 15845376-4 2005 Furthermore, in the V-1 transfectants, the amount of CapZ which physically associated with V-1 was steeply reduced at 2h after treatment with forskolin, but was thereafter increased to reach its initial level at 12h after forskolin-treatment. Colforsin 142-151 capping actin protein of muscle Z-line subunit beta Homo sapiens 53-57 15845376-4 2005 Furthermore, in the V-1 transfectants, the amount of CapZ which physically associated with V-1 was steeply reduced at 2h after treatment with forskolin, but was thereafter increased to reach its initial level at 12h after forskolin-treatment. Colforsin 142-151 immunoglobulin kappa variable 1-5 Homo sapiens 91-94 15845376-4 2005 Furthermore, in the V-1 transfectants, the amount of CapZ which physically associated with V-1 was steeply reduced at 2h after treatment with forskolin, but was thereafter increased to reach its initial level at 12h after forskolin-treatment. Colforsin 222-231 immunoglobulin kappa variable 1-5 Homo sapiens 20-23 15845376-4 2005 Furthermore, in the V-1 transfectants, the amount of CapZ which physically associated with V-1 was steeply reduced at 2h after treatment with forskolin, but was thereafter increased to reach its initial level at 12h after forskolin-treatment. Colforsin 222-231 capping actin protein of muscle Z-line subunit beta Homo sapiens 53-57 15845376-4 2005 Furthermore, in the V-1 transfectants, the amount of CapZ which physically associated with V-1 was steeply reduced at 2h after treatment with forskolin, but was thereafter increased to reach its initial level at 12h after forskolin-treatment. Colforsin 222-231 immunoglobulin kappa variable 1-5 Homo sapiens 91-94 15625084-2 2005 In transiently transfected MDCK-C7 cells, stimulation with forskolin induced translocation of AQP2-WT to the plasma membrane. Colforsin 59-68 aquaporin 2 Rattus norvegicus 94-101 15625084-3 2005 Treatment of AQP2-WT cells with the PKA inhibitor H-89 following forskolin stimulation resulted in internalization of AQP2-WT. Colforsin 65-74 aquaporin 2 Rattus norvegicus 13-17 15625084-3 2005 Treatment of AQP2-WT cells with the PKA inhibitor H-89 following forskolin stimulation resulted in internalization of AQP2-WT. Colforsin 65-74 aquaporin 2 Rattus norvegicus 13-20 15625084-4 2005 Moreover, H-89 treatment of AQP2-S256D (mimicking constitutively phosphorylated AQP2 and hence localized to the plasma membrane) resulted in redistribution of AQP2-S256D to intracellular vesicles, even in the presence of forskolin. Colforsin 221-230 aquaporin 2 Rattus norvegicus 28-32 15625084-4 2005 Moreover, H-89 treatment of AQP2-S256D (mimicking constitutively phosphorylated AQP2 and hence localized to the plasma membrane) resulted in redistribution of AQP2-S256D to intracellular vesicles, even in the presence of forskolin. Colforsin 221-230 aquaporin 2 Rattus norvegicus 80-84 15625084-4 2005 Moreover, H-89 treatment of AQP2-S256D (mimicking constitutively phosphorylated AQP2 and hence localized to the plasma membrane) resulted in redistribution of AQP2-S256D to intracellular vesicles, even in the presence of forskolin. Colforsin 221-230 aquaporin 2 Rattus norvegicus 80-84 15625084-5 2005 Both PGE2 and dopamine stimulation induced endocytosis of AQP2-WT and AQP2-S256D, respectively, in forskolin-stimulated cells. Colforsin 99-108 aquaporin 2 Rattus norvegicus 58-62 15956721-6 2005 However, overexpression of type V AC, which is activated by PKCzeta, showed synergistic stimulation of cAMP by relaxin and forskolin. Colforsin 123-132 protein kinase C zeta Homo sapiens 60-67 15883646-13 2005 Forskolin, a cAMP agonist, mimicked PTHrP action, and the PKC inhibitor, GF109203X, slightly blocked downregulation of cyclin D1, implying involvement of both cAMP and PKC. Colforsin 0-9 parathyroid hormone-like peptide Mus musculus 36-41 15632412-6 2005 CD suspensions from CD ET-1 KO mice had enhanced AVP- and forskolin-stimulated cAMP accumulation. Colforsin 58-67 endothelin 1 Mus musculus 23-27 15814298-5 2005 Forskolin stimulated the promoter activity of the HSD17B5 gene through this Sp1/Sp3 binding site. Colforsin 0-9 Sp3 transcription factor Homo sapiens 80-83 15814298-6 2005 Mutation of this site resulted in a significant reduction of HSD17B5 promoter basal and forskolin-induced activity. Colforsin 88-97 aldo-keto reductase family 1 member C3 Homo sapiens 61-68 15689617-5 2005 Stimulation of the A2A-R using CGS21680, forskolin, and a constitutively active cAMP-response element-binding protein (CREB) mutant elevated the reduced promoter activity of the A2A-R gene by mutant Htt. Colforsin 41-50 adenosine A2a receptor Rattus norvegicus 19-24 15886804-10 2005 Elevating cAMP levels with PGI(2) or forskolin precludes thrombin-induced p27 and p31 tyrosine phosphorylation. Colforsin 37-46 coagulation factor II, thrombin Homo sapiens 57-65 15886804-10 2005 Elevating cAMP levels with PGI(2) or forskolin precludes thrombin-induced p27 and p31 tyrosine phosphorylation. Colforsin 37-46 interferon alpha inducible protein 27 Homo sapiens 74-77 15886804-10 2005 Elevating cAMP levels with PGI(2) or forskolin precludes thrombin-induced p27 and p31 tyrosine phosphorylation. Colforsin 37-46 proteasome 26S subunit, non-ATPase 8 Homo sapiens 82-85 15705651-8 2005 PGE(2) exposure increased the evoked TTX-R I(Na) when experiments were performed at both room temperature and at 37 degrees C. Furthermore, stimulation of the adenylyl cyclase/protein kinase A pathway with either forskolin or Sp-5,6-DCl-cBiMPS potentiated the TTX-R I(Na) in a manner similar to that of PGE(2). Colforsin 213-222 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 176-192 15769548-7 2005 Quantitative-PCR analysis revealed that forskolin induced four-fold increase of gicerin mRNA. Colforsin 40-49 melanoma cell adhesion molecule Mus musculus 80-87 15769548-9 2005 We found that a CRE site located at 60 bp upstream of gicerin gene was responsible for the increase of its mRNA induced by forskolin. Colforsin 123-132 melanoma cell adhesion molecule Mus musculus 54-61 15689617-5 2005 Stimulation of the A2A-R using CGS21680, forskolin, and a constitutively active cAMP-response element-binding protein (CREB) mutant elevated the reduced promoter activity of the A2A-R gene by mutant Htt. Colforsin 41-50 adenosine A2a receptor Rattus norvegicus 178-183 15710610-7 2005 Calmodulin inhibitors also blocked both cholera toxin- and forskolin-stimulated cAMP accumulation. Colforsin 59-68 calmodulin 1 Rattus norvegicus 0-10 15777731-3 2005 Dominant-negative forms of AP2alpha not only prevented the AP2alpha-mediated activation of CKB but also blocked the cAMP-mediated increase in CKB transcription caused by forskolin treatment. Colforsin 170-179 transcription factor AP-2 alpha Homo sapiens 27-35 15777731-3 2005 Dominant-negative forms of AP2alpha not only prevented the AP2alpha-mediated activation of CKB but also blocked the cAMP-mediated increase in CKB transcription caused by forskolin treatment. Colforsin 170-179 creatine kinase B Homo sapiens 91-94 15777731-3 2005 Dominant-negative forms of AP2alpha not only prevented the AP2alpha-mediated activation of CKB but also blocked the cAMP-mediated increase in CKB transcription caused by forskolin treatment. Colforsin 170-179 creatine kinase B Homo sapiens 142-145 15817919-0 2005 Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO. Colforsin 0-9 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 62-67 15814084-0 2005 Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin. Colforsin 63-72 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 37-43 15814084-1 2005 Forskolin and cAMP have been shown to have paradoxical effects in the regulation of expression levels of mRNA of cytochrome P450 3A (CYP3A) family members. Colforsin 0-9 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 113-131 15814084-1 2005 Forskolin and cAMP have been shown to have paradoxical effects in the regulation of expression levels of mRNA of cytochrome P450 3A (CYP3A) family members. Colforsin 0-9 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 133-138 15814084-2 2005 We demonstrate in this study that forskolin upregulated the promoter for CYP3A4 independent of its ability to increase cAMP levels. Colforsin 34-43 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 73-79 15814084-3 2005 This activity was explained showing forskolin directly activated the pregnane-X-receptor, a known regulator of CYP3A genes. Colforsin 36-45 nuclear receptor subfamily 1 group I member 2 Homo sapiens 69-88 15814084-3 2005 This activity was explained showing forskolin directly activated the pregnane-X-receptor, a known regulator of CYP3A genes. Colforsin 36-45 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 111-116 15903125-6 2005 Expression of this variant of adenylyl cyclase VI (whether expressed as the S674 human adenylyl cyclase VI [ADCY6] or the S686 ADCY6 rat analog) is characterized by a significant decrease in stimulated adenylyl cyclase activity (forskolin-stimulated activity of the S674 human ADCY6 variant was decreased to 56% +/- 6% of the activity of the A674 variant [mean +/- SEM]; n = 9; P = .004). Colforsin 229-238 adenylate cyclase 6 Homo sapiens 108-113 15903125-8 2005 Paralleling this phenotype, expression of the variant was associated with attenuation of the forskolin-mediated reduction in cell growth rate to 64% +/- 5% of the effect seen with expression of the wild-type ADCY6 (n = 4; P = .001). Colforsin 93-102 adenylate cyclase 6 Homo sapiens 208-213 15650079-6 2005 Transient cotransfections with an inhibin promoter-luciferase reporter in a mouse granulosa cell line, GRMO2 cells, show that C/EBPbeta is capable of repressing both basal and forskolin-stimulated inhibin gene promoter activities. Colforsin 176-185 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 126-135 15572654-8 2005 Melatonin prevented the forskolin-induced inhibition (95%) of leptin expression. Colforsin 24-33 leptin Rattus norvegicus 62-68 15574486-9 2005 In the duodenum, the baseline rate of HCO3- secretion measured in mucosal tissue mounted in Ussing chambers was decreased by approximately 30% (P<0.03), whereas the forskolin-stimulated component of HCO3- secretion was the same in wild-type and Slc26a6-/- mice. Colforsin 168-177 solute carrier family 26, member 6 Mus musculus 248-255 15817919-5 2005 The results of reverse transcriptase (RT)-PCR suggest that the amount of CYP19 gene transcript was also up-regulated by FSK synergistically with Dex, and that promoter I.4, which is not activated by FSK alone, is activated by FSK synergistically with Dex. Colforsin 120-123 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 73-78 15772523-9 2005 PKA-inhibition by H-89 further decreased infarct size beyond preconditioning or forskolin. Colforsin 80-89 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-3 15790911-4 2005 CFTR activation by forskolin or a selective activator caused further sustained hyperpolarization to -50 to -60 mV. Colforsin 19-28 cystic fibrosis transmembrane conductance regulator Mus musculus 0-4 15821107-9 2005 hCG increased cAMP synthesis in carp pituitary cells and hCG-induced GH mRNA expression was mimicked by forskolin but suppressed by inhibiting adenylate cyclase and protein kinase A. Colforsin 104-113 hypertrichosis 2 (generalised, congenital) Homo sapiens 0-3 15772523-6 2005 In a third series, forskolin (0.3 muM, 5 minutes, 10 minutes washout prior to ischemia) increased PKA activity and reduced infarct size. Colforsin 19-28 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 98-101 15772523-7 2005 Prior H-89 decreased PKA activity after 5 minutes of forskolin and further reduced infarct size versus forskolin alone. Colforsin 53-62 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 21-24 15797749-10 2005 Treatment with NKH477 inhibited IFN-gamma and IL-10 expression, whereas expression of these cytokines were markedly upregulated in the untreated allografts. Colforsin 15-21 interferon gamma Rattus norvegicus 32-41 15797749-10 2005 Treatment with NKH477 inhibited IFN-gamma and IL-10 expression, whereas expression of these cytokines were markedly upregulated in the untreated allografts. Colforsin 15-21 interleukin 10 Rattus norvegicus 46-51 15821110-8 2005 Both ANP and C-ANP-(4-23) could inhibit the effect of forskolin on CEO maturation, and these inhibitory effects of ANP/C-ANP-(4-23) could be blocked by preincubation with pertussis toxin (PT), consistent with mediation by a Gi protein(s) in the cumulus cells. Colforsin 54-63 natriuretic peptides A Sus scrofa 5-8 15821110-8 2005 Both ANP and C-ANP-(4-23) could inhibit the effect of forskolin on CEO maturation, and these inhibitory effects of ANP/C-ANP-(4-23) could be blocked by preincubation with pertussis toxin (PT), consistent with mediation by a Gi protein(s) in the cumulus cells. Colforsin 54-63 natriuretic peptides A Sus scrofa 15-18 15773901-4 2005 The co-localization of ep24.15 and 14-3-3 epsilon was increased by exposure of HEK293 cells (human embryonic kidney cells) to forskolin (10 microm). Colforsin 126-135 thimet oligopeptidase 1 Homo sapiens 23-49 15725338-10 2005 Immunoblots showed that SKF 38393 enhanced CREB phosphorylation and the stimulatory effect was abolished by SCH 23390 whereas quinpirole inhibited forskolin-stimulated phosphorylated CREB production and the inhibitory effect was prevented by spiperone. Colforsin 147-156 cAMP responsive element binding protein 1 Bos taurus 183-187 15814101-7 2005 For the first time, we show that GW405833 selectively binds both rat and human CB2 receptors with high affinity, where it acts as a partial agonist (approximately 50% reduction of forskolin-mediated cAMP production compared to the full cannabinoid agonist, CP55,940). Colforsin 180-189 cannabinoid receptor 2 Homo sapiens 79-82 15821110-8 2005 Both ANP and C-ANP-(4-23) could inhibit the effect of forskolin on CEO maturation, and these inhibitory effects of ANP/C-ANP-(4-23) could be blocked by preincubation with pertussis toxin (PT), consistent with mediation by a Gi protein(s) in the cumulus cells. Colforsin 54-63 natriuretic peptides A Sus scrofa 15-18 15821107-9 2005 hCG increased cAMP synthesis in carp pituitary cells and hCG-induced GH mRNA expression was mimicked by forskolin but suppressed by inhibiting adenylate cyclase and protein kinase A. Colforsin 104-113 hypertrichosis 2 (generalised, congenital) Homo sapiens 57-60 15821110-8 2005 Both ANP and C-ANP-(4-23) could inhibit the effect of forskolin on CEO maturation, and these inhibitory effects of ANP/C-ANP-(4-23) could be blocked by preincubation with pertussis toxin (PT), consistent with mediation by a Gi protein(s) in the cumulus cells. Colforsin 54-63 natriuretic peptides A Sus scrofa 15-18 15821110-9 2005 All these results suggest that ANP is a multifunctional regulator of FSH and forskolin on pig CEO maturation by two signalling mechanisms: one is via a cGMP/PKG pathway, the other is via NPRC receptors in cumulus cells and the activation of the PT-sensitive Gi protein(s). Colforsin 77-86 natriuretic peptides A Sus scrofa 31-34 15821110-0 2005 Atrial natriuretic peptide inhibits the actions of FSH and forskolin in meiotic maturation of pig oocytes via different signalling pathways. Colforsin 59-68 natriuretic peptides A Sus scrofa 0-26 15509660-7 2005 Forskolin significantly increased Ser(16)-HSP20 phosphorylation. Colforsin 0-9 HSPB6 Sus scrofa 42-47 15647289-9 2005 Ser412 --> Ala TAK1 abolished the stimulatory effects of forskolin on those cellular events induced by tumor necrosis factor alpha. Colforsin 60-69 tumor necrosis factor Mus musculus 106-133 15647289-10 2005 Ser412 --> Ala TAK1 also inhibited the forskolin-induced up-regulation of interleukin 6 production in RAW264.7 cells treated with lipopolysaccharide. Colforsin 42-51 mitogen-activated protein kinase kinase kinase 7 Mus musculus 18-22 15647289-10 2005 Ser412 --> Ala TAK1 also inhibited the forskolin-induced up-regulation of interleukin 6 production in RAW264.7 cells treated with lipopolysaccharide. Colforsin 42-51 interleukin 6 Mus musculus 77-90 15771421-9 2005 The (N)-methanocarba-5"-uronamide analogues were full agonists at the A(3)AR, as indicated by the inhibition of forskolin-stimluated adenylate cyclase at a concentration of 10 microM. Colforsin 112-121 adenosine A3 receptor Homo sapiens 70-76 15781644-6 2005 Consistent with these results, the protein kinase A (PKA) pathway activators forskolin and dibutyryl cAMP and the PKA pathway inhibitor H-89, respectively, increased or repressed human osteocalcin and bone sialoprotein promoter activities. Colforsin 77-86 bone gamma-carboxyglutamate protein Homo sapiens 185-196 15763242-5 2005 In basolateral membrane-permeabilized cells, TMP, as well as forskolin and IBMX, induced an I(SC) response, which was sensitive to MDL-12330A, H89, and specific channel blocker CFTR(inh-172), but insensitive to apical application of 4-4"-didsothiocyanostilbene-2, 2"-disulfonic acid (DIDS) and basolateral pretreatment with BAPTA-AM. Colforsin 61-70 CF transmembrane conductance regulator Homo sapiens 177-181 15647289-8 2005 Furthermore, forskolin enhanced tumor necrosis factor alpha-induced I kappa B alpha degradation, p38 MAPK phosphorylation, and osteoclastic differentiation in RAW264.7 cells. Colforsin 13-22 tumor necrosis factor Mus musculus 32-59 15647289-8 2005 Furthermore, forskolin enhanced tumor necrosis factor alpha-induced I kappa B alpha degradation, p38 MAPK phosphorylation, and osteoclastic differentiation in RAW264.7 cells. Colforsin 13-22 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 68-83 15647289-8 2005 Furthermore, forskolin enhanced tumor necrosis factor alpha-induced I kappa B alpha degradation, p38 MAPK phosphorylation, and osteoclastic differentiation in RAW264.7 cells. Colforsin 13-22 mitogen-activated protein kinase 14 Mus musculus 97-100 15647289-9 2005 Ser412 --> Ala TAK1 abolished the stimulatory effects of forskolin on those cellular events induced by tumor necrosis factor alpha. Colforsin 60-69 mitogen-activated protein kinase kinase kinase 7 Mus musculus 18-22 15777774-2 2005 CSP-2503 reduced rectal temperature and 5-HT neuronal hypothalamic activity in mice, decreased electrical activity of raphe nuclei cells in rats and blocked the enhancement of adenylate cyclase activity induced by forskolin in HeLa cells transfected with the human 5-HT1A receptor. Colforsin 214-223 5-hydroxytryptamine receptor 1A Homo sapiens 265-280 15509660-8 2005 The relationship between Ser(16)-HSP20 phosphorylation and force remained linear and was shifted downward in partially activated muscles relaxed with forskolin. Colforsin 150-159 HSPB6 Sus scrofa 33-38 15605363-8 2005 The use of a PKA inhibitor further confirmed the specificity of 8-br-cAMP and forskolin"s effect on Cx43. Colforsin 78-87 gap junction protein alpha 1 Homo sapiens 100-104 15598676-6 2005 Forskolin treatment also prolonged CYP17 mRNA half-life in both normal and PCOS theca cells. Colforsin 0-9 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 35-40 15598676-7 2005 In vitro mRNA degradation studies demonstrated that the 5"-untranslated region confers increased stability to CYP17 mRNA in PCOS theca cells and showed that the 5"-untranslated region of CYP17 also confers forskolin-stimulated stabilization of CYP17 mRNA. Colforsin 206-215 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 187-192 15598676-7 2005 In vitro mRNA degradation studies demonstrated that the 5"-untranslated region confers increased stability to CYP17 mRNA in PCOS theca cells and showed that the 5"-untranslated region of CYP17 also confers forskolin-stimulated stabilization of CYP17 mRNA. Colforsin 206-215 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 187-192 15543559-3 2005 Forskolin, a direct activator of adenylyl cyclase, reduced the thrombin-induced p38 MAP kinase phosphorylation, and significantly suppressed the thrombin-stimulated accumulation of HSP27. Colforsin 0-9 coagulation factor II, thrombin Homo sapiens 145-153 15543559-3 2005 Forskolin, a direct activator of adenylyl cyclase, reduced the thrombin-induced p38 MAP kinase phosphorylation, and significantly suppressed the thrombin-stimulated accumulation of HSP27. Colforsin 0-9 heat shock protein family B (small) member 1 Homo sapiens 181-186 15543559-3 2005 Forskolin, a direct activator of adenylyl cyclase, reduced the thrombin-induced p38 MAP kinase phosphorylation, and significantly suppressed the thrombin-stimulated accumulation of HSP27. Colforsin 0-9 coagulation factor II, thrombin Homo sapiens 63-71 15543559-7 2005 Moreover, forskolin reduced the p38 MAP kinase phosphorylation induced by the 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC-activating phorbol ester, and significantly suppressed the TPA-stimulated accumulation of HSP27. Colforsin 10-19 mitogen-activated protein kinase 14 Homo sapiens 32-35 15543559-3 2005 Forskolin, a direct activator of adenylyl cyclase, reduced the thrombin-induced p38 MAP kinase phosphorylation, and significantly suppressed the thrombin-stimulated accumulation of HSP27. Colforsin 0-9 mitogen-activated protein kinase 14 Homo sapiens 80-83 15543559-7 2005 Moreover, forskolin reduced the p38 MAP kinase phosphorylation induced by the 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC-activating phorbol ester, and significantly suppressed the TPA-stimulated accumulation of HSP27. Colforsin 10-19 heat shock protein family B (small) member 1 Homo sapiens 218-223 15377280-7 2005 The inhibitory effects of PGE2 on IGF-I-induced chemotaxis, membrane ruffling and Rac activation were faithfully reproduced by a low concentration of forskolin, which induced a comparable extent of cAMP elevation as with 10(-8) M PGE2, and were potentiated by isobutylmethylxanthine. Colforsin 150-159 insulin-like growth factor I Cricetulus griseus 34-39 15635621-3 2005 We now report that in cultured rat Schwann cells, expression of mRNA encoding neuropilin-2 (NRP2) and plexin-A3 (PlexA3), proteins involved in semaphorin-3F (Sema3F) signal transduction, is diminished markedly by forskolin, an adenylate cyclase activator that, like axonal contact, induces Schwann cell synthesis of myelin lipids and proteins. Colforsin 213-222 neuropilin 2 Rattus norvegicus 78-90 15635621-3 2005 We now report that in cultured rat Schwann cells, expression of mRNA encoding neuropilin-2 (NRP2) and plexin-A3 (PlexA3), proteins involved in semaphorin-3F (Sema3F) signal transduction, is diminished markedly by forskolin, an adenylate cyclase activator that, like axonal contact, induces Schwann cell synthesis of myelin lipids and proteins. Colforsin 213-222 neuropilin 2 Rattus norvegicus 92-96 15635621-3 2005 We now report that in cultured rat Schwann cells, expression of mRNA encoding neuropilin-2 (NRP2) and plexin-A3 (PlexA3), proteins involved in semaphorin-3F (Sema3F) signal transduction, is diminished markedly by forskolin, an adenylate cyclase activator that, like axonal contact, induces Schwann cell synthesis of myelin lipids and proteins. Colforsin 213-222 plexin A3 Rattus norvegicus 102-111 15635621-3 2005 We now report that in cultured rat Schwann cells, expression of mRNA encoding neuropilin-2 (NRP2) and plexin-A3 (PlexA3), proteins involved in semaphorin-3F (Sema3F) signal transduction, is diminished markedly by forskolin, an adenylate cyclase activator that, like axonal contact, induces Schwann cell synthesis of myelin lipids and proteins. Colforsin 213-222 plexin A3 Rattus norvegicus 113-119 15635621-3 2005 We now report that in cultured rat Schwann cells, expression of mRNA encoding neuropilin-2 (NRP2) and plexin-A3 (PlexA3), proteins involved in semaphorin-3F (Sema3F) signal transduction, is diminished markedly by forskolin, an adenylate cyclase activator that, like axonal contact, induces Schwann cell synthesis of myelin lipids and proteins. Colforsin 213-222 semaphorin 3F Rattus norvegicus 158-164 15550390-8 2005 Similar studies with forskolin, a direct activator of adenylate cyclase, also demonstrated inhibition of cAMP and its downstream response by IFN-gamma. Colforsin 21-30 interferon gamma Homo sapiens 141-150 15671868-4 2005 Because previous reports showed that RGS2 attenuates activity of adenylyl cyclase, RGS2 protein level and sensitivity of adenylyl cyclase to forskolin was tested 2 h after administration of MK-801 (1 mg/kg). Colforsin 141-150 regulator of G-protein signaling 2 Rattus norvegicus 37-41 15652238-6 2005 CCRF-CEM cells, a well-studied model of glucocorticoid and cAMP-induced apoptosis, differed from B-CLL cells in that stimulation of adenylyl cyclase with the diterpene forskolin was required to increase both glucocorticoid-mediated apoptosis and GRE activation, while PDE4 inhibition had no effect. Colforsin 168-177 phosphodiesterase 4A Homo sapiens 268-272 15652238-8 2005 While rolipram treatment up-regulated PDE4B in B-CLL, forskolin treatment up-regulated PDE4D in CCRF-CEM cells. Colforsin 54-63 phosphodiesterase 4D Homo sapiens 87-92 15787695-0 2005 Differential effects of forskolin on tyrosine hydroxylase gene transcription in identified brainstem catecholaminergic neuronal subtypes in organotypic culture. Colforsin 24-33 tyrosine hydroxylase Homo sapiens 37-57 15733090-3 2005 In undifferentiated RN46A cells stably transfected with the wild-type 5-HT1A receptor, 5-HT1A receptor activation inhibited forskolin-induced cyclic adenosine monophosphate (cAMP) formation (by 50%), increased [Ca2+]i, and induced a novel inhibition (up to 60%) of phospho-p42/p44-mitogen-activated protein kinase (MAPK). Colforsin 124-133 5-hydroxytryptamine receptor 1A Rattus norvegicus 70-76 15733090-3 2005 In undifferentiated RN46A cells stably transfected with the wild-type 5-HT1A receptor, 5-HT1A receptor activation inhibited forskolin-induced cyclic adenosine monophosphate (cAMP) formation (by 50%), increased [Ca2+]i, and induced a novel inhibition (up to 60%) of phospho-p42/p44-mitogen-activated protein kinase (MAPK). Colforsin 124-133 5-hydroxytryptamine receptor 1A Rattus norvegicus 87-93 15787695-3 2005 In the presence of TTX, the adenylcyclase stimulator, forskolin, produced a 155% increase in LC, a 130% increase in A1, and a 220% increase in A2 in TH hnRNA as compared to control nuclei. Colforsin 54-63 tyrosine hydroxylase Homo sapiens 149-151 15787695-5 2005 In contrast, the robust increase in TH transcription produced by forskolin in A2 neurons, was completely inhibited by PD98059, and only partially inhibited by H89, showing that induced TH transcription is mediated by different kinase pathways in specific central noradrenergic neuronal subtypes. Colforsin 65-74 tyrosine hydroxylase Homo sapiens 36-38 15605383-10 2005 By contrast, it was blocked by CGP55845 (1 microM; -0.4% +/- 3.4%; n=5) a potent GABAB receptor antagonist, and by forskolin (50 microM; 9.9% +/- 5.2%; n=4), an adenylyl cyclase activator, and H-89 (1 microM; 6.9% +/- 3.9%; n=4), a protein kinase A (PKA) inhibitor. Colforsin 115-124 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 232-248 15389590-4 2005 Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h). Colforsin 228-237 interleukin 1 alpha Homo sapiens 108-127 15389590-4 2005 Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h). Colforsin 228-237 interleukin 1 alpha Homo sapiens 129-138 15389590-5 2005 A poorly metabolizable analog of cAMP, dibutyryl-cAMP, mimicked forskolin effect on ICAM-1 surface expression. Colforsin 64-73 intercellular adhesion molecule 1 Homo sapiens 84-90 15389590-6 2005 Protein kinase A (PKA) inhibitor H89 prevented forskolin effect on ICAM-1 surface expression. Colforsin 47-56 intercellular adhesion molecule 1 Homo sapiens 67-73 15389590-4 2005 Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h). Colforsin 27-36 tumor necrosis factor Homo sapiens 63-90 15389590-4 2005 Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h). Colforsin 27-36 tumor necrosis factor Homo sapiens 92-101 15389590-4 2005 Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h). Colforsin 27-36 interleukin 1 alpha Homo sapiens 108-127 15389590-4 2005 Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h). Colforsin 27-36 interleukin 1 alpha Homo sapiens 129-138 15389590-4 2005 Pretreatment of HUVEC with forskolin significantly upregulated tumor necrosis factor alpha (TNF-alpha)- and interleukin-1 alpha (IL1-alpha)-induced ICAM-1 surface expression exclusively after a prolonged time of incubation with forskolin (at least 7-8 h). Colforsin 27-36 intercellular adhesion molecule 1 Homo sapiens 148-154 15605383-10 2005 By contrast, it was blocked by CGP55845 (1 microM; -0.4% +/- 3.4%; n=5) a potent GABAB receptor antagonist, and by forskolin (50 microM; 9.9% +/- 5.2%; n=4), an adenylyl cyclase activator, and H-89 (1 microM; 6.9% +/- 3.9%; n=4), a protein kinase A (PKA) inhibitor. Colforsin 115-124 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 250-253 15625103-6 2005 CFs engineered to overexpress type 6 AC had enhanced forskolin-promoted cAMP formation, greater inhibition by forskolin of TGF-beta-stimulated alpha-SMA expression, and a decrease in the EC(50) of forskolin to reduce serum-stimulated collagen synthesis. Colforsin 110-119 transforming growth factor, beta 1 Rattus norvegicus 123-131 15986093-3 2005 In single oocytes expressing CFTR, an increase in cAMP caused by forskolin application induced a Cl(-) current and increased membrane conductance; application of diphenylamine carboxylic acid (CFTR blocker) readily blocked the Cl(-) current. Colforsin 65-74 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 29-33 15986093-3 2005 In single oocytes expressing CFTR, an increase in cAMP caused by forskolin application induced a Cl(-) current and increased membrane conductance; application of diphenylamine carboxylic acid (CFTR blocker) readily blocked the Cl(-) current. Colforsin 65-74 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 193-197 15986093-4 2005 With co-expression of CFTR and Cx45, application of forskolin to paired oocytes induced a typical outward current and increased junctional conductance (G(j)). Colforsin 52-61 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 22-26 15986093-4 2005 With co-expression of CFTR and Cx45, application of forskolin to paired oocytes induced a typical outward current and increased junctional conductance (G(j)). Colforsin 52-61 gap junction protein gamma 1 L homeolog Xenopus laevis 31-35 15615861-7 2005 Treatment of primary cultures of human granulosa cells with forskolin and FSH rapidly increased the NGFI-B mRNA levels followed by an increase in 3beta-hydroxysteroid dehydrogenase type 2 (HSD3B2). Colforsin 60-69 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Homo sapiens 189-195 15695169-6 2005 Ramelteon inhibited forskolin-stimulated cAMP production in the CHO cells that express the human MT1 or MT2 receptors. Colforsin 20-29 metallothionein 1I, pseudogene Homo sapiens 97-100 15695169-6 2005 Ramelteon inhibited forskolin-stimulated cAMP production in the CHO cells that express the human MT1 or MT2 receptors. Colforsin 20-29 melatonin receptor 1B Homo sapiens 104-107 15691881-5 2005 Activation of PKA by forskolin resulted in enhanced androgen-induced expression of the PSA gene, an effect that was blocked by the AR antagonist, bicalutamide. Colforsin 21-30 kallikrein related peptidase 3 Homo sapiens 87-90 15691881-5 2005 Activation of PKA by forskolin resulted in enhanced androgen-induced expression of the PSA gene, an effect that was blocked by the AR antagonist, bicalutamide. Colforsin 21-30 androgen receptor Homo sapiens 131-133 15691881-8 2005 Furthermore, chromatin immunoprecipitation showed that the combination of androgen and forskolin increased phosphorylated CREB occupancy, which was accompanied by histone acetylation, at the putative cAMP responsive element located in the 5" upstream regulatory region of the PSA gene. Colforsin 87-96 cAMP responsive element binding protein 1 Homo sapiens 122-126 15691881-8 2005 Furthermore, chromatin immunoprecipitation showed that the combination of androgen and forskolin increased phosphorylated CREB occupancy, which was accompanied by histone acetylation, at the putative cAMP responsive element located in the 5" upstream regulatory region of the PSA gene. Colforsin 87-96 kallikrein related peptidase 3 Homo sapiens 276-279 15615861-4 2005 Real-time RT-PCR was used to quantify mRNA expression levels of the NGFI-B family members in human ovarian follicles, corpora lutea and in human granulosa cells after FSH, phorbol ester (TPA) and forskolin treatment. Colforsin 196-205 nuclear receptor subfamily 4 group A member 1 Homo sapiens 68-74 15615861-6 2005 In human granulosa tumour (HGT) cells, the NGFI-B expression increased after TPA, and to a lesser extent, after forskolin treatment. Colforsin 112-121 nuclear receptor subfamily 4 group A member 1 Homo sapiens 43-49 15615861-7 2005 Treatment of primary cultures of human granulosa cells with forskolin and FSH rapidly increased the NGFI-B mRNA levels followed by an increase in 3beta-hydroxysteroid dehydrogenase type 2 (HSD3B2). Colforsin 60-69 nuclear receptor subfamily 4 group A member 1 Homo sapiens 100-106 15607531-5 2005 Forskolin and cholera toxin suppressed the osteocalcin synthesis while dideoxyforskolin, a forskolin derivative that does not activate adenylyl cyclase, had little effect on the synthesis. Colforsin 0-9 bone gamma-carboxyglutamate protein 2 Mus musculus 43-54 15607531-7 2005 DBcAMP and forskolin markedly reduced the phosphorylation of p38 MAP stimulated by T(3). Colforsin 11-20 mitogen-activated protein kinase 14 Mus musculus 61-64 15625103-4 2005 A 24-h incubation of CF with TGF-beta or angiotensin II increased alpha-SMA expression, which was inhibited by the AC agonist forskolin and a cAMP analog that activates protein kinase A. Colforsin 126-135 transforming growth factor, beta 1 Rattus norvegicus 29-37 15625103-4 2005 A 24-h incubation of CF with TGF-beta or angiotensin II increased alpha-SMA expression, which was inhibited by the AC agonist forskolin and a cAMP analog that activates protein kinase A. Colforsin 126-135 angiotensinogen Rattus norvegicus 41-55 15625103-4 2005 A 24-h incubation of CF with TGF-beta or angiotensin II increased alpha-SMA expression, which was inhibited by the AC agonist forskolin and a cAMP analog that activates protein kinase A. Colforsin 126-135 actin gamma 2, smooth muscle Rattus norvegicus 66-75 15625103-5 2005 Treatment with forskolin blunted serum-, TGF-beta-, and angiotensin II-stimulated collagen synthesis. Colforsin 15-24 transforming growth factor, beta 1 Rattus norvegicus 41-49 15625103-5 2005 Treatment with forskolin blunted serum-, TGF-beta-, and angiotensin II-stimulated collagen synthesis. Colforsin 15-24 angiotensinogen Rattus norvegicus 56-70 15625103-6 2005 CFs engineered to overexpress type 6 AC had enhanced forskolin-promoted cAMP formation, greater inhibition by forskolin of TGF-beta-stimulated alpha-SMA expression, and a decrease in the EC(50) of forskolin to reduce serum-stimulated collagen synthesis. Colforsin 110-119 actin gamma 2, smooth muscle Rattus norvegicus 143-152 15625103-6 2005 CFs engineered to overexpress type 6 AC had enhanced forskolin-promoted cAMP formation, greater inhibition by forskolin of TGF-beta-stimulated alpha-SMA expression, and a decrease in the EC(50) of forskolin to reduce serum-stimulated collagen synthesis. Colforsin 110-119 transforming growth factor, beta 1 Rattus norvegicus 123-131 15625103-6 2005 CFs engineered to overexpress type 6 AC had enhanced forskolin-promoted cAMP formation, greater inhibition by forskolin of TGF-beta-stimulated alpha-SMA expression, and a decrease in the EC(50) of forskolin to reduce serum-stimulated collagen synthesis. Colforsin 110-119 actin gamma 2, smooth muscle Rattus norvegicus 143-152 15912208-2 2005 We evaluated the temporal pattern of the effects of corticotropin (ACTH) and the adenylyl cyclase activator forskolin on the level of SF-1 mRNA, and compared the time course of induction of SF-1 with that of CYP11A1. Colforsin 108-117 splicing factor 1 Mus musculus 134-138 15513924-2 2005 In this study we have presented evidence that treatment of human mesangial cells (HMC) with endothelin 1 (ET-1) and stimulation of adenylate cyclase with either forskolin or with the cAMP analog 8-Br-cAMP activated the GTP loading of Cdc42. Colforsin 161-170 cell division cycle 42 Homo sapiens 234-239 15630084-7 2005 Upon stimulation with forskolin, HeLa cells expressing AKIP1 accumulated higher levels of the endogenous C subunit in the nucleus. Colforsin 22-31 A-kinase interacting protein 1 Homo sapiens 55-60 15912208-4 2005 The effect of forskolin was augmented by cycloheximide, suggesting that an inhibitory protein, whose synthesis was inhibited by cycloheximide, could be involved in negative regulation of SF-1 expression. Colforsin 14-23 splicing factor 1 Mus musculus 187-191 15345481-9 2005 Indeed, pull-down assays demonstrated Rap1 activation by serum and forskolin in VSM. Colforsin 67-76 RAP1A, member of RAS oncogene family Homo sapiens 38-42 15458982-5 2005 Inhibition of FAK phosphorylation and morphological changes were mimicked by forskolin, inhibited by H89, and prevented by the protein tyrosine phosphatase inhibitor vanadate and by calpeptin. Colforsin 77-86 protein tyrosine kinase 2 Homo sapiens 14-17 15654840-3 2005 We showed in this study that the neurotrophic peptide PACAP (pituitary adenylate cyclase-activating polypeptide) mimicked the effect of forskolin, a direct activator of adenylate cyclase, on the actin cytoskeleton of primary rat astrocytes. Colforsin 136-145 adenylate cyclase activating polypeptide 1 Rattus norvegicus 54-59 16353668-4 2005 A Northern blot analysis with the use of a radiolabeled cDNA probe, and immunodetection with antibodies directed against SF-1, demonstrated that the Sf-1 transcript and the SF-1 protein levels were lowered by TGF-beta in Y-1 adrenocortical cells, both in untreated and adenylyl cyclase activator, forskolin-treated cells. Colforsin 297-306 transforming growth factor beta 1 Homo sapiens 209-217 19003050-4 2005 siRNA-mediated reduction of the expression of PLCgamma2, but not PLCgamma1, inhibited both the phosphorylation of CREB at S133 and the activation of CREB-dependent transcription following treatment of cells with forskolin or ionomycin, which increases the intracellular concentrations of cAMP or Ca(2+), respectively. Colforsin 212-221 phospholipase C, gamma 2 Rattus norvegicus 46-55 19003050-4 2005 siRNA-mediated reduction of the expression of PLCgamma2, but not PLCgamma1, inhibited both the phosphorylation of CREB at S133 and the activation of CREB-dependent transcription following treatment of cells with forskolin or ionomycin, which increases the intracellular concentrations of cAMP or Ca(2+), respectively. Colforsin 212-221 cAMP responsive element binding protein 1 Rattus norvegicus 114-118 19003050-4 2005 siRNA-mediated reduction of the expression of PLCgamma2, but not PLCgamma1, inhibited both the phosphorylation of CREB at S133 and the activation of CREB-dependent transcription following treatment of cells with forskolin or ionomycin, which increases the intracellular concentrations of cAMP or Ca(2+), respectively. Colforsin 212-221 cAMP responsive element binding protein 1 Rattus norvegicus 149-153 16353668-4 2005 A Northern blot analysis with the use of a radiolabeled cDNA probe, and immunodetection with antibodies directed against SF-1, demonstrated that the Sf-1 transcript and the SF-1 protein levels were lowered by TGF-beta in Y-1 adrenocortical cells, both in untreated and adenylyl cyclase activator, forskolin-treated cells. Colforsin 297-306 splicing factor 1 Homo sapiens 149-153 15654840-3 2005 We showed in this study that the neurotrophic peptide PACAP (pituitary adenylate cyclase-activating polypeptide) mimicked the effect of forskolin, a direct activator of adenylate cyclase, on the actin cytoskeleton of primary rat astrocytes. Colforsin 136-145 adenylate cyclase activating polypeptide 1 Rattus norvegicus 61-111 15654840-4 2005 The depolymerization of stress fibres induced by PACAP or forskolin was prevented by the expression of a constitutively active mutant of RhoA, but not by a protein kinase A (PKA) blocker, indicating that cAMP-raising agents act upstream of RhoA, in a PKA-independent manner. Colforsin 58-67 ras homolog family member A Rattus norvegicus 137-141 15654840-4 2005 The depolymerization of stress fibres induced by PACAP or forskolin was prevented by the expression of a constitutively active mutant of RhoA, but not by a protein kinase A (PKA) blocker, indicating that cAMP-raising agents act upstream of RhoA, in a PKA-independent manner. Colforsin 58-67 cathelicidin antimicrobial peptide Rattus norvegicus 204-208 15654840-4 2005 The depolymerization of stress fibres induced by PACAP or forskolin was prevented by the expression of a constitutively active mutant of RhoA, but not by a protein kinase A (PKA) blocker, indicating that cAMP-raising agents act upstream of RhoA, in a PKA-independent manner. Colforsin 58-67 ras homolog family member A Rattus norvegicus 240-244 15654840-4 2005 The depolymerization of stress fibres induced by PACAP or forskolin was prevented by the expression of a constitutively active mutant of RhoA, but not by a protein kinase A (PKA) blocker, indicating that cAMP-raising agents act upstream of RhoA, in a PKA-independent manner. Colforsin 58-67 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 251-254 15390106-1 2005 Forskolin and heregulin synergistically drive human Schwann cell (HSC) proliferation in vitro, but the role of forskolin is not completely understood. Colforsin 0-9 fucosyltransferase 1 (H blood group) Homo sapiens 66-69 15390106-3 2005 We then determined the effect of forskolin and heregulin on receptor expression in HSC cultured from nerve roots using Western blotting and RNase protection assays. Colforsin 33-42 fucosyltransferase 1 (H blood group) Homo sapiens 83-86 15390106-4 2005 HER2 and HER3 were expressed in nonmyelinating Schwann cells in roots and in cultured HSCs before exposure to forskolin. Colforsin 110-119 erb-b2 receptor tyrosine kinase 2 Homo sapiens 0-4 15596837-6 2005 Interestingly, in COS-7 cells transfected with BILF1 expression constructs, a decrease in forskolin-induced CRE-mediated transcription was measured, as well as an increase in NF-kappaB-mediated transcription. Colforsin 90-99 membrane protein BILF1 Human gammaherpesvirus 4 47-52 15390106-6 2005 Treatment with forskolin for 24 h consistently increased HER2 and HER3 protein levels in HSCs but did not alter HER2 and HER3 mRNA levels. Colforsin 15-24 erb-b2 receptor tyrosine kinase 2 Homo sapiens 57-61 15390106-6 2005 Treatment with forskolin for 24 h consistently increased HER2 and HER3 protein levels in HSCs but did not alter HER2 and HER3 mRNA levels. Colforsin 15-24 erb-b2 receptor tyrosine kinase 3 Homo sapiens 66-70 15390106-8 2005 When both heregulin and forskolin were present, HER2 and HER3 protein levels were similar to initial control values. Colforsin 24-33 erb-b2 receptor tyrosine kinase 2 Homo sapiens 48-52 15390106-8 2005 When both heregulin and forskolin were present, HER2 and HER3 protein levels were similar to initial control values. Colforsin 24-33 erb-b2 receptor tyrosine kinase 3 Homo sapiens 57-61 15390106-4 2005 HER2 and HER3 were expressed in nonmyelinating Schwann cells in roots and in cultured HSCs before exposure to forskolin. Colforsin 110-119 erb-b2 receptor tyrosine kinase 3 Homo sapiens 9-13 15596846-9 2005 Furthermore, BILF1 is able to inhibit forskolin-triggered CREB activation via stimulation of endogenous G proteins in a pertussis toxin-sensitive manner, verifying that BILF1 signals constitutively through Galphai. Colforsin 38-47 membrane protein BILF1 Human gammaherpesvirus 4 13-18 15596846-9 2005 Furthermore, BILF1 is able to inhibit forskolin-triggered CREB activation via stimulation of endogenous G proteins in a pertussis toxin-sensitive manner, verifying that BILF1 signals constitutively through Galphai. Colforsin 38-47 cAMP responsive element binding protein 1 Homo sapiens 58-62 15596846-9 2005 Furthermore, BILF1 is able to inhibit forskolin-triggered CREB activation via stimulation of endogenous G proteins in a pertussis toxin-sensitive manner, verifying that BILF1 signals constitutively through Galphai. Colforsin 38-47 membrane protein BILF1 Human gammaherpesvirus 4 169-174 15601837-3 2005 We found that cAMP-elevating reagents, prostacyclin and forskolin, decreased cell permeability and enhanced vascular endothelial (VE) cadherin-dependent cell adhesion. Colforsin 56-65 cadherin 5 Homo sapiens 108-142 14628144-5 2005 We investigated the effects of p38 MAP kinase inhibitor SB-203580, MEK/ERK kinase inhibitor PD-098059 and Raf-1 inhibitor forskolin, and demonstrated that they modulate cytokine mRNA expression in a different manner as a consequence of the use of porins or LPS as stimuli. Colforsin 122-131 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 106-111 15475573-6 2005 Inhibition of PDE4 activity decreased migration, and in conjunction with forskolin, increased cAMP in all VECs studied. Colforsin 73-82 phosphodiesterase 4A Homo sapiens 14-18 15601837-7 2005 Furthermore, prostacyclin and forskolin induced cortical actin rearrangement in a Rap1-dependent manner. Colforsin 30-39 RAB guanine nucleotide exchange factor 1 Homo sapiens 82-86 15470083-3 2005 In contrast to in vitro observations, we observed a PKC-mediated enhancement of forskolin- and isoproterenol-stimulated cyclic AMP accumulation in HEK-AC6 cells. Colforsin 80-89 proline rich transmembrane protein 2 Homo sapiens 52-55 15470083-3 2005 In contrast to in vitro observations, we observed a PKC-mediated enhancement of forskolin- and isoproterenol-stimulated cyclic AMP accumulation in HEK-AC6 cells. Colforsin 80-89 adenylate cyclase 6 Homo sapiens 151-154 15470083-7 2005 Furthermore, the forskolin-stimulated activity of a recombinant AC6 in which the putative Raf1 regulatory sites have been eliminated was not potentiated by activation of PKC. Colforsin 17-26 adenylate cyclase 6 Homo sapiens 64-67 15470083-7 2005 Furthermore, the forskolin-stimulated activity of a recombinant AC6 in which the putative Raf1 regulatory sites have been eliminated was not potentiated by activation of PKC. Colforsin 17-26 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 90-94 15617735-5 2005 The IC51-mediated induction of cAMP levels, downstream target of A2A and A2B, and inhibition of LPS/IFNgamma-induced expression of iNOS by forskolin, a cAMP activator, document a role for cAMP mediated pathway in anti-inflammatory activity of IC51. Colforsin 139-148 interferon gamma Homo sapiens 100-108 15617735-5 2005 The IC51-mediated induction of cAMP levels, downstream target of A2A and A2B, and inhibition of LPS/IFNgamma-induced expression of iNOS by forskolin, a cAMP activator, document a role for cAMP mediated pathway in anti-inflammatory activity of IC51. Colforsin 139-148 nitric oxide synthase 2 Homo sapiens 131-135 15730866-6 2005 An increase in cAMP by forskolin resulted in a persistent, uniform increase of the phosphorylated CREB (pCREB/CREB immunofluorescence ratio) in all hippocampal principal neurons. Colforsin 23-32 cAMP responsive element binding protein 1 Rattus norvegicus 98-102 15730866-6 2005 An increase in cAMP by forskolin resulted in a persistent, uniform increase of the phosphorylated CREB (pCREB/CREB immunofluorescence ratio) in all hippocampal principal neurons. Colforsin 23-32 cAMP responsive element binding protein 1 Rattus norvegicus 105-109 15456755-4 2004 In the presence of 20 microm forskolin, CFP-HSL translocated to the triacylglycerol droplet, coincident with BODIPY-FA labeled depots. Colforsin 29-38 lipase E, hormone sensitive type Homo sapiens 44-47 15581358-7 2004 We show that 7C1b-S inhibits Gsalpha-stimulated and Gsalpha-forskolin stimulated activity in our soluble ACVII model system. Colforsin 60-69 GNAS complex locus Homo sapiens 52-59 15456755-5 2004 Fluorescence resonance energy transfer analysis demonstrated that CFP-HSL associated with YFP-adipocyte FABP in both basal and forskolin-treated cells. Colforsin 127-136 lipase E, hormone sensitive type Homo sapiens 70-73 15539636-6 2004 Moreover, forskolin, an adenylyl cyclase activator, also elevates PI3K activity and inhibition of PI3K enhances forskolin-induced contractile response in a betaARK-ct sensitive manner. Colforsin 10-19 G protein-coupled receptor kinase 2 Rattus norvegicus 156-163 15539636-6 2004 Moreover, forskolin, an adenylyl cyclase activator, also elevates PI3K activity and inhibition of PI3K enhances forskolin-induced contractile response in a betaARK-ct sensitive manner. Colforsin 112-121 G protein-coupled receptor kinase 2 Rattus norvegicus 156-163 15282196-6 2004 Studies with IBMX and varying doses of forskolin indicated that small increases in cAMP, on the order of those generated by IBMX alone and the PTHrP peptides, were sufficient to protect lung cancer cells from apoptosis. Colforsin 39-48 parathyroid hormone like hormone Homo sapiens 143-148 15271660-4 2004 Therefore, in the present study we investigated the effect of forskolin (5 microM)- and rolipram (10 microM)-induced cAMP increase on reduction of barrier functions in response to Rac-1 inhibition by Clostridium sordellii lethal toxin (LT). Colforsin 62-71 Rac family small GTPase 1 Mus musculus 180-185 15381251-0 2004 Egr-1 modulation of synapsin I expression: permissive effect of forskolin via cAMP. Colforsin 64-73 early growth response 1 Rattus norvegicus 0-5 15271668-7 2004 In the presence of the PDE5 inhibitor MY-5445, the repression of the NO donor response accompanying forskolin was prevented. Colforsin 100-109 phosphodiesterase 5A Homo sapiens 23-27 15306545-6 2004 Glibenclamide, a blocker of CFTR, eliminated the genistein-stimulated increase of I(sc) and reduced the forskolin-activated I(sc). Colforsin 104-113 cystic fibrosis transmembrane conductance regulator Mus musculus 28-32 15545289-2 2004 BK was able to inhibit the cAMP production induced by forskolin with a potency 100-fold lower at the hGPR100 (pEC(50) = 6.6) than that measured at the hB(2)R (pEC(50) = 8.6). Colforsin 54-63 relaxin family peptide/INSL5 receptor 4 Homo sapiens 101-108 15286033-11 2004 Cycloheximide blocked the LH- or forskolin-induced MMP-19 mRNA expression, demonstrating the requirement for new protein synthesis. Colforsin 33-42 matrix metallopeptidase 19 Rattus norvegicus 51-57 15557287-3 2004 IBMX and forskolin both caused concentration dependent, right-downward shifts in the concentration-response curves of KCl and cholecystokinin (CCK). Colforsin 9-18 cholecystokinin Homo sapiens 126-141 15557287-3 2004 IBMX and forskolin both caused concentration dependent, right-downward shifts in the concentration-response curves of KCl and cholecystokinin (CCK). Colforsin 9-18 cholecystokinin Homo sapiens 143-146 15381251-5 2004 Furthermore, Egr-1 alone had minimal effects on synapsin I expression whereas forskolin treatment of PC12 cells profoundly affected the ability of Egr-1 to regulate synapsin I expression. Colforsin 78-87 early growth response 1 Rattus norvegicus 147-152 15381251-5 2004 Furthermore, Egr-1 alone had minimal effects on synapsin I expression whereas forskolin treatment of PC12 cells profoundly affected the ability of Egr-1 to regulate synapsin I expression. Colforsin 78-87 synapsin I Rattus norvegicus 165-175 15561916-6 2004 Our studies demonstrated that forskolin-generated cAMP resulted in activation of mTOR at basal glucose concentrations as assessed by phosphorylation of S6K1, a downstream effector of mTOR. Colforsin 30-39 mechanistic target of rapamycin kinase Homo sapiens 81-85 15561916-6 2004 Our studies demonstrated that forskolin-generated cAMP resulted in activation of mTOR at basal glucose concentrations as assessed by phosphorylation of S6K1, a downstream effector of mTOR. Colforsin 30-39 ribosomal protein S6 kinase B1 Homo sapiens 152-156 15561916-6 2004 Our studies demonstrated that forskolin-generated cAMP resulted in activation of mTOR at basal glucose concentrations as assessed by phosphorylation of S6K1, a downstream effector of mTOR. Colforsin 30-39 mechanistic target of rapamycin kinase Homo sapiens 183-187 15389554-6 2004 hOCT1 expressed in CHO-cells was inhibited by protein kinase A (PKA) activation (1 microM forskolin, -58 +/- 6%, n = 12), calmodulin inhibition (0.1 microM calmidazolium, -68 +/- 3%, n = 6; 10 microM ophiobolin A, -48 +/- 10%, n = 7), calmodulin-dependent kinase II inhibition (1 microM KN62, -78 +/- 4%, n = 12), and inhibition of p56(lck) tyrosine kinase (10 microM aminogenistein, -35 +/- 7%, n = 12). Colforsin 90-99 solute carrier family 22 member 1 Homo sapiens 0-5 15319355-9 2004 Forskolin, an activator of adenylyl cyclase, stimulated expression of CYP11A/luciferase by 4.5 +/- 0.9-fold (P < 0.001) and did not enhance transcriptional drive by exogenous CamKIV. Colforsin 0-9 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 70-76 15319355-9 2004 Forskolin, an activator of adenylyl cyclase, stimulated expression of CYP11A/luciferase by 4.5 +/- 0.9-fold (P < 0.001) and did not enhance transcriptional drive by exogenous CamKIV. Colforsin 0-9 calcium/calmodulin dependent protein kinase IV Homo sapiens 178-184 15319355-12 2004 The dominant-negative mutant of the cAMP-responsive element binding protein also repressed forskolin"s stimulation of -100/+23 CYP11A/luciferase by 12, 38, and 52% (P < 0.01). Colforsin 91-100 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 127-133 15528042-1 2004 We reported previously that cAMP analogues or cAMP synthesis activator (forskolin; FSK) inhibit lipopolysaccharide (LPS)-induced inducible nitric-oxide systase (iNOS) gene expression in astrocytes, while they enhance that in macrophages. Colforsin 72-81 nitric oxide synthase 2 Homo sapiens 129-159 15528042-1 2004 We reported previously that cAMP analogues or cAMP synthesis activator (forskolin; FSK) inhibit lipopolysaccharide (LPS)-induced inducible nitric-oxide systase (iNOS) gene expression in astrocytes, while they enhance that in macrophages. Colforsin 72-81 nitric oxide synthase 2 Homo sapiens 161-165 15579770-7 2004 TSHr signal transduction was evaluated by analyzing the effect of stimulators (cholera toxin, 8-bromo-cAMP, forskolin, and 12-O-tetradecanoyl-phorbol-13-acetate) and inhibitors (2",5"-dideoxyadenosine and staurosporine) on VEGF protein levels under basal and TSH-stimulated conditions. Colforsin 108-117 thyroid stimulating hormone receptor Rattus norvegicus 0-4 15572345-6 2004 The augmenting effect of phorbol esters or forskolin is blocked by various PKC or PKA inhibitors, indicating the involvement of these kinases. Colforsin 43-52 protein kinase C, gamma Rattus norvegicus 75-78 15579773-0 2004 Forskolin, 8-Br-3",5"-cyclic adenosine 5"-monophosphate, and catalytic protein kinase A expression in the nucleus increase radioiodide uptake and sodium/iodide symporter protein levels in RET/PTC1-expressing cells. Colforsin 0-9 ret proto-oncogene Rattus norvegicus 188-191 15579773-4 2004 We showed that both forskolin and 8-Br-cAMP increase radioiodide uptake and NIS protein in RET/PTC1-expressing cells to the same extent as the parental PC Cl 3 cells. Colforsin 20-29 ret proto-oncogene Rattus norvegicus 91-94 15579773-5 2004 We found that RET/PTC1 decreases nuclear localization of catalytic PKA, and forskolin treatment was able to counteract this RET/PTC1 effect. Colforsin 76-85 ret proto-oncogene Rattus norvegicus 14-17 15579773-5 2004 We found that RET/PTC1 decreases nuclear localization of catalytic PKA, and forskolin treatment was able to counteract this RET/PTC1 effect. Colforsin 76-85 ret proto-oncogene Rattus norvegicus 124-127 15572345-6 2004 The augmenting effect of phorbol esters or forskolin is blocked by various PKC or PKA inhibitors, indicating the involvement of these kinases. Colforsin 43-52 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 82-85 15569313-0 2004 Extracellular calcium antagonizes forskolin-induced aquaporin 2 trafficking in collecting duct cells. Colforsin 34-43 aquaporin 2 Homo sapiens 52-63 15569313-9 2004 RESULTS: We demonstrated that extracellular calcium (Ca2+ o) (5 mmol/L) strongly inhibited forskolin-stimulated increase in AQP2 expression in the apical plasma membrane. Colforsin 91-100 aquaporin 2 Homo sapiens 124-128 15569313-15 2004 CONCLUSION: Together, these data demonstrate that extracellular calcium, possibly acting through the endogenous CaR, antagonizes forskolin-induced AQP2 translocation to the apical plasma membrane in CD8 cells. Colforsin 129-138 aquaporin 2 Homo sapiens 147-151 15361543-4 2004 In the first approach, we constructed Galpha(s)-insensitive mutants of AC1 (F293L and Y973S) that retained sensitivity to Ca2+ and forskolin activation. Colforsin 131-140 adenylate cyclase 1 Homo sapiens 71-74 15340044-7 2004 Treatment with forskolin, an activator of adenylyl cyclase, restored both CREB-1 and pCREB-1 levels; this resulted in the restoration of CRE-binding, CRE-reporter activity, and CREB-1 and RFC mRNA levels. Colforsin 15-24 cAMP responsive element binding protein 1 Homo sapiens 74-80 15340044-7 2004 Treatment with forskolin, an activator of adenylyl cyclase, restored both CREB-1 and pCREB-1 levels; this resulted in the restoration of CRE-binding, CRE-reporter activity, and CREB-1 and RFC mRNA levels. Colforsin 15-24 cAMP responsive element binding protein 1 Homo sapiens 177-191 15361543-5 2004 Persistent (2 h) activation of the D2 dopamine receptor resulted in a significant augmentation of basal or Ca(2+)- and forskolin-stimulated AC1 activity; however, sensitization of Galpha(s)-insensitive mutants of AC1 was markedly reduced compared with wild-type AC1. Colforsin 119-128 dopamine receptor D2 Homo sapiens 35-55 15375165-2 2004 Here we show that infusion of forskolin, a specific cAMP-dependent protein kinase A (PKA) activator, into the lateral ventricle of brain in adult rats induced activation of PKA by severalfold and concurrently enhanced the phosphorylation of tau at Ser-214, Ser-198, Ser-199, and or Ser-202 (Tau-1 site) and Ser-396 and or Ser-404 (PHF-1 site), which are among the major abnormally hyperphosphorylated sites seen in AD. Colforsin 30-39 PHD finger protein 1 Rattus norvegicus 331-336 15361543-5 2004 Persistent (2 h) activation of the D2 dopamine receptor resulted in a significant augmentation of basal or Ca(2+)- and forskolin-stimulated AC1 activity; however, sensitization of Galpha(s)-insensitive mutants of AC1 was markedly reduced compared with wild-type AC1. Colforsin 119-128 adenylate cyclase 1 Homo sapiens 140-143 15375165-4 2004 Infusion of forskolin together with PKA inhibitor or glycogen synthase kinase-3 (GSK-3) inhibitor revealed that the phosphorylation of tau at Ser-214 was catalyzed by PKA and that the phosphorylation at both the Tau-1 and the PHF-1 sites is induced by basal level of GSK-3, because forskolin activated PKA and not GSK-3 and inhibition of the latter inhibited the phosphorylation at Tau-1 and PHF-1 sites. Colforsin 12-21 PHD finger protein 1 Rattus norvegicus 226-231 15375165-4 2004 Infusion of forskolin together with PKA inhibitor or glycogen synthase kinase-3 (GSK-3) inhibitor revealed that the phosphorylation of tau at Ser-214 was catalyzed by PKA and that the phosphorylation at both the Tau-1 and the PHF-1 sites is induced by basal level of GSK-3, because forskolin activated PKA and not GSK-3 and inhibition of the latter inhibited the phosphorylation at Tau-1 and PHF-1 sites. Colforsin 12-21 PHD finger protein 1 Rattus norvegicus 392-397 15390118-3 2004 Pre-treatment of microglia with TNF reduced in a dose- and time-dependent manner cAMP accumulation induced by forskolin (FSK), in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (IBMX). Colforsin 110-119 tumor necrosis factor-like Rattus norvegicus 32-35 15531103-5 2004 Immunoblot analysis of perirhinal cortical neurons using GluR1 and GluR1-S845 phosphorylation state specific antibodies showed that stimulation of adenylyl cyclase (AC) with forskolin (FSK) dramatically increased PKA-mediated phosphorylation of GluR1-S845. Colforsin 174-183 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 57-62 15531103-5 2004 Immunoblot analysis of perirhinal cortical neurons using GluR1 and GluR1-S845 phosphorylation state specific antibodies showed that stimulation of adenylyl cyclase (AC) with forskolin (FSK) dramatically increased PKA-mediated phosphorylation of GluR1-S845. Colforsin 174-183 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 67-72 15531103-5 2004 Immunoblot analysis of perirhinal cortical neurons using GluR1 and GluR1-S845 phosphorylation state specific antibodies showed that stimulation of adenylyl cyclase (AC) with forskolin (FSK) dramatically increased PKA-mediated phosphorylation of GluR1-S845. Colforsin 174-183 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 67-72 15531103-5 2004 Immunoblot analysis of perirhinal cortical neurons using GluR1 and GluR1-S845 phosphorylation state specific antibodies showed that stimulation of adenylyl cyclase (AC) with forskolin (FSK) dramatically increased PKA-mediated phosphorylation of GluR1-S845. Colforsin 185-188 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 67-72 15531103-5 2004 Immunoblot analysis of perirhinal cortical neurons using GluR1 and GluR1-S845 phosphorylation state specific antibodies showed that stimulation of adenylyl cyclase (AC) with forskolin (FSK) dramatically increased PKA-mediated phosphorylation of GluR1-S845. Colforsin 185-188 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 67-72 15347661-4 2004 GRIP1 was down-regulated in transiently transfected COS-1 cells after treatment with 8-para-chlorophenylthio-cAMP or forskolin and 3-isobutyl-1-methylxanthine and in adrenocortical Y1 cells after incubation with adrenocorticotropic hormone. Colforsin 117-126 glutamate receptor interacting protein 1 Mus musculus 0-5 15548648-5 2004 Although PHCCC reduced the increase in cAMP formation and phospho-AKT levels induced by forskolin, none of these transduction pathways significantly contributed to the reduction of [3H]thymidine incorporation. Colforsin 88-97 AKT serine/threonine kinase 1 Rattus norvegicus 66-69 15390118-3 2004 Pre-treatment of microglia with TNF reduced in a dose- and time-dependent manner cAMP accumulation induced by forskolin (FSK), in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (IBMX). Colforsin 121-124 tumor necrosis factor-like Rattus norvegicus 32-35 15390118-6 2004 The target of TNF appeared to be adenylyl cyclase, whose ability to synthesize cAMP was markedly reduced (up to 50%) in membranes prepared from TNF-treated microglial cells, both in basal conditions and after stimulation with FSK. Colforsin 226-229 tumor necrosis factor-like Rattus norvegicus 14-17 15390118-6 2004 The target of TNF appeared to be adenylyl cyclase, whose ability to synthesize cAMP was markedly reduced (up to 50%) in membranes prepared from TNF-treated microglial cells, both in basal conditions and after stimulation with FSK. Colforsin 226-229 tumor necrosis factor-like Rattus norvegicus 144-147 15390118-8 2004 The same inhibitors also markedly prevented the reduction of FSK-evoked cAMP accumulation by TNF, suggesting the involvement of NFkappaB in the regulation of adenylyl cyclase by TNF in microglia. Colforsin 61-64 tumor necrosis factor-like Rattus norvegicus 93-96 15390118-8 2004 The same inhibitors also markedly prevented the reduction of FSK-evoked cAMP accumulation by TNF, suggesting the involvement of NFkappaB in the regulation of adenylyl cyclase by TNF in microglia. Colforsin 61-64 tumor necrosis factor-like Rattus norvegicus 178-181 15465011-2 2004 This discovery was based on our finding that HN suppressed forskolin-induced cAMP production in Chinese hamster ovary (CHO) cells expressing human FPRL1 (CHO-hFPRL1) or human FPRL2 (CHO-hFPRL2). Colforsin 59-68 formyl peptide receptor 2 Homo sapiens 147-152 15355970-3 2004 The Ca(2+) signal-induced expression of PACAP mRNA was enhanced by forskolin, which evokes cAMP signals. Colforsin 67-76 adenylate cyclase activating polypeptide 1 Rattus norvegicus 40-45 15355970-5 2004 On the other hand, sole administration of forskolin markedly reduced the cellular content of PACAP mRNA, which was restored by the addition of Ca(2+) signals. Colforsin 42-51 adenylate cyclase activating polypeptide 1 Rattus norvegicus 93-98 15465011-2 2004 This discovery was based on our finding that HN suppressed forskolin-induced cAMP production in Chinese hamster ovary (CHO) cells expressing human FPRL1 (CHO-hFPRL1) or human FPRL2 (CHO-hFPRL2). Colforsin 59-68 formyl peptide receptor 2 Homo sapiens 158-164 15465011-2 2004 This discovery was based on our finding that HN suppressed forskolin-induced cAMP production in Chinese hamster ovary (CHO) cells expressing human FPRL1 (CHO-hFPRL1) or human FPRL2 (CHO-hFPRL2). Colforsin 59-68 formyl peptide receptor 3 Homo sapiens 175-180 15465019-7 2004 Exposure of the cells to forskolin induced a translocation of both, human and mouse LASP-1, from the focal contacts to the cell interior without affecting F-actin structure. Colforsin 25-34 LIM and SH3 protein 1 Mus musculus 84-90 15246972-2 2004 Exposure of human umbilical vein endothelial cells to forskolin or dibutyryl cAMP, which increase intracellular cAMP by separate mechanisms, inhibited the thrombin-induced ICAM-1 expression. Colforsin 54-63 coagulation factor II, thrombin Homo sapiens 155-163 15246972-7 2004 We observed that treating cells with forskolin blocked the activation of p38 MAPK, and inhibition of p38 MAPK interfered with phosphorylation of RelA/p65 induced by thrombin. Colforsin 37-46 mitogen-activated protein kinase 14 Homo sapiens 73-76 15246972-2 2004 Exposure of human umbilical vein endothelial cells to forskolin or dibutyryl cAMP, which increase intracellular cAMP by separate mechanisms, inhibited the thrombin-induced ICAM-1 expression. Colforsin 54-63 intercellular adhesion molecule 1 Homo sapiens 172-178 15246972-7 2004 We observed that treating cells with forskolin blocked the activation of p38 MAPK, and inhibition of p38 MAPK interfered with phosphorylation of RelA/p65 induced by thrombin. Colforsin 37-46 coagulation factor II, thrombin Homo sapiens 165-173 15666819-3 2004 To this end we isolated marmoset and rhesus adrenocortical cells, and treated the cells with known regulators of P450c17 expression for 48 h. P450c17 protein increased with Forskolin (F) treatment, but was marginally inhibited by AII (A) and TPA (T) alone. Colforsin 173-182 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 142-149 15265766-3 2004 The PKA inhibitor H-89 abolished the inhibitory effects of forskolin on NHE3 activity, but not that of 7-OH-DPAT. Colforsin 59-68 solute carrier family 9 member A3 Rattus norvegicus 72-76 15475517-8 2004 In CEC but not in AEC, FSK induced delocalization of VE-cadherin and paxillin from cellular adhesion complexes as indicated by cell fractionation and immunofluorescence microscopy. Colforsin 23-26 cadherin 5 Homo sapiens 53-64 15485496-2 2004 3-Isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor, and forskolin increased the amplitude of evoked inhibitory postsynaptic currents (eIPSCs) in a sensitive manner to protein kinase A (PKA) inhibition (with KT-5720). Colforsin 71-80 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 182-198 15284208-3 2004 Similar effects of AR mRNA induction were seen in T cells treated with cAMP-elevating agents such as prostaglandin E(2) and forskolin as well as with the phosphodiesterase inhibitors rolipram and isobutylmethylxanthine. Colforsin 124-133 amphiregulin Homo sapiens 19-21 15389839-1 2004 Using a combination of targeted differential display for induced protein kinases and differential library screening, we identified mitogen-activated protein kinase activated protein kinase 2 (MAPKAPK2), as a primary response gene whose transcription is stimulated by membrane depolarization and by forskolin in rat PC12 pheochromocytoma cells. Colforsin 298-307 MAPK activated protein kinase 2 Rattus norvegicus 131-190 15389839-1 2004 Using a combination of targeted differential display for induced protein kinases and differential library screening, we identified mitogen-activated protein kinase activated protein kinase 2 (MAPKAPK2), as a primary response gene whose transcription is stimulated by membrane depolarization and by forskolin in rat PC12 pheochromocytoma cells. Colforsin 298-307 MAPK activated protein kinase 2 Rattus norvegicus 192-200 15246976-4 2004 CFTR(inh)-172 produced 1.1 +/- 0.9- and 4.3 +/- 0.7-mV depolarizations when added after low Cl- and forskolin, respectively. Colforsin 100-109 cystic fibrosis transmembrane conductance regulator Mus musculus 0-4 15246976-5 2004 Systemically administered CFTR(inh)-172 reduced the forskolin-induced hyperpolarization from 4.7 +/- 0.4 to 0.9 +/- 0.1 mV but did not reduce the low Cl(-)-induced hyperpolarization. Colforsin 52-61 cystic fibrosis transmembrane conductance regulator Mus musculus 26-30 15485490-9 2004 Inhibition of Akt prevents forskolin-induced phosphorylation of Ser897, suggesting a role for Akt in the mediation of the modulation of NMDA receptors by cAMP. Colforsin 27-36 AKT serine/threonine kinase 1 Homo sapiens 14-17 15485490-9 2004 Inhibition of Akt prevents forskolin-induced phosphorylation of Ser897, suggesting a role for Akt in the mediation of the modulation of NMDA receptors by cAMP. Colforsin 27-36 AKT serine/threonine kinase 1 Homo sapiens 94-97 15485496-2 2004 3-Isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor, and forskolin increased the amplitude of evoked inhibitory postsynaptic currents (eIPSCs) in a sensitive manner to protein kinase A (PKA) inhibition (with KT-5720). Colforsin 71-80 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 200-203 15299023-6 2004 In NG108-15 cells, ethanol and forskolin activation of type I PKA also inhibits several components of the MAPK pathway including B-Raf kinase, ERK1/2, and p90RSK phosphorylation. Colforsin 31-40 mitogen-activated protein kinase 1 Mus musculus 106-110 15369705-6 2004 Pretreatment of MT1-CHO cells, transfected with the nonsense probes and exposed to melatonin, resulted in a desensitization of the receptor, an increase in forskolin-induced cAMP accumulation, an increase in 2-[125I]-iodomelatonin binding and no change in the affinity of melatonin for the MT1 receptor. Colforsin 156-165 metallothionein-1 Cricetulus griseus 16-19 15369705-7 2004 However, knockdown of either beta-tubulin or RGS4 in MT1-CHO cells followed by pretreatment with melatonin attenuated the desensitization of melatonin receptors, decreased total 2-[125I]-iodomelatonin binding, and did not affect neither the forskolin response nor the affinity of melatonin for the MT1 receptor. Colforsin 241-250 LOW QUALITY PROTEIN: regulator of G-protein signaling 4 Cricetulus griseus 45-49 15299023-1 2004 We have shown that the two types of cAMP-dependent protein kinase (PKA) in NG108-15 cells differentially mediate forskolin- and ethanol-induced cAMP response element (CRE)-binding protein (CREB) phosphorylation and CRE-mediated gene transcription. Colforsin 113-122 cAMP responsive element binding protein 1 Mus musculus 189-193 15299023-4 2004 We show here that CBP is required for forskolin- and ethanol-induced CRE-mediated gene expression. Colforsin 38-47 CREB binding protein Mus musculus 18-21 15299023-6 2004 In NG108-15 cells, ethanol and forskolin activation of type I PKA also inhibits several components of the MAPK pathway including B-Raf kinase, ERK1/2, and p90RSK phosphorylation. Colforsin 31-40 mitogen-activated protein kinase 3 Mus musculus 143-149 15299023-6 2004 In NG108-15 cells, ethanol and forskolin activation of type I PKA also inhibits several components of the MAPK pathway including B-Raf kinase, ERK1/2, and p90RSK phosphorylation. Colforsin 31-40 ribosomal protein S6 kinase, polypeptide 2 Mus musculus 155-161 15163620-6 2004 Forskolin and vasopressin induced HKalpha(2) mRNA levels, and CREB overexpression stimulated the activity of HKalpha(2) promoter-luciferase constructs. Colforsin 0-9 ATPase, H+/K+ transporting, nongastric, alpha polypeptide Mus musculus 109-119 15299023-5 2004 Forskolin- and ethanol-induced CBP phosphorylation, demonstrable at 10 min, persists up to 24 h. CBP phosphorylation requires type I PKA but not type II PKA. Colforsin 0-9 CREB binding protein Mus musculus 31-34 15299023-5 2004 Forskolin- and ethanol-induced CBP phosphorylation, demonstrable at 10 min, persists up to 24 h. CBP phosphorylation requires type I PKA but not type II PKA. Colforsin 0-9 CREB binding protein Mus musculus 97-100 15163620-6 2004 Forskolin and vasopressin induced HKalpha(2) mRNA levels, and CREB overexpression stimulated the activity of HKalpha(2) promoter-luciferase constructs. Colforsin 0-9 ATPase, H+/K+ transporting, nongastric, alpha polypeptide Mus musculus 34-44 15240013-0 2004 Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain. Colforsin 57-66 cAMP responsive element binding protein 1 Mus musculus 26-30 15447679-3 2004 We found that treatment of mouse hippocampal slices with either phorbol ester, to activate PKC, or forskolin, to activate PKA, resulted in activation of Mnk1 and increased eIF4E phosphorylation that was dependent on extracellular signal-regulated kinase (ERK). Colforsin 99-108 mitogen-activated protein kinase 3 Mus musculus 153-157 15381636-12 2004 ACVI myocytes had higher steady-state intracellular cAMP levels than GFP myocytes when unstimulated (GFP vs ACVI=6.60+/-0.98 vs 14.2+/-2.1 fmol cAMP/viable cell, n=4, P<0.05) and in the presence of 1 microm isoprenaline or 10 microm forskolin. Colforsin 236-245 adenylate cyclase 6 Rattus norvegicus 0-4 15381636-15 2004 ACVI myocyte responses were increased for forskolin (E(max): GFP=6.70+/-1.59 (n=6); ACVI=9.06+/-0.69 (n=14), P<0.01) but not isoprenaline. Colforsin 42-51 adenylate cyclase 6 Rattus norvegicus 0-4 15231710-12 2004 Acute stimulation of ARO and BCPAP cells with forskolin increased Egr-1, but not PTEN, protein levels. Colforsin 46-55 early growth response 1 Homo sapiens 66-71 15231710-12 2004 Acute stimulation of ARO and BCPAP cells with forskolin increased Egr-1, but not PTEN, protein levels. Colforsin 46-55 phosphatase and tensin homolog Homo sapiens 81-85 15381038-12 2004 NECA and FSK also induced ERK1 and ERK2 activation similar to ADO. Colforsin 9-12 mitogen-activated protein kinase 3 Bos taurus 26-30 15381038-12 2004 NECA and FSK also induced ERK1 and ERK2 activation similar to ADO. Colforsin 9-12 mitogen-activated protein kinase 1 Bos taurus 35-39 15525573-9 2004 Under basal conditions, cAMP-GEFI expression increased progressively throughout culture, and this could be further enhanced when cells were incubated with increasing doses of LH and forskolin. Colforsin 182-191 Rap guanine nucleotide exchange factor 3 Homo sapiens 24-33 15525573-11 2004 The results show that increases in cAMP generated by LH and forskolin, in addition to activating PKA, also induce increases in cAMP-GEFI protein expression in luteinizing human granulosa cells. Colforsin 60-69 Rap guanine nucleotide exchange factor 3 Homo sapiens 127-136 15464232-6 2004 We evaluated if the effects of forskolin on cholangiocyte functions are associated with changes in the cAMP/PKA/Src/MEK/ERK1/2 pathway. Colforsin 31-40 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 112-115 15464232-6 2004 We evaluated if the effects of forskolin on cholangiocyte functions are associated with changes in the cAMP/PKA/Src/MEK/ERK1/2 pathway. Colforsin 31-40 mitogen activated protein kinase 3 Rattus norvegicus 120-126 15464232-9 2004 In vitro, in pure isolated cholangiocytes, forskolin increased cholangiocyte proliferation, which was ablated by Rp-cAMPs, PP2 and PD98059. Colforsin 43-52 calmodulin 2, pseudogene 1 Rattus norvegicus 116-121 15464232-10 2004 The effects of forskolin on cholangiocyte proliferation were associated with increased activity of PKA, Src Tyrosine 139 (Tyr 139) and ERK1/2. Colforsin 15-24 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 104-107 15464232-10 2004 The effects of forskolin on cholangiocyte proliferation were associated with increased activity of PKA, Src Tyrosine 139 (Tyr 139) and ERK1/2. Colforsin 15-24 mitogen activated protein kinase 3 Rattus norvegicus 135-141 15447679-3 2004 We found that treatment of mouse hippocampal slices with either phorbol ester, to activate PKC, or forskolin, to activate PKA, resulted in activation of Mnk1 and increased eIF4E phosphorylation that was dependent on extracellular signal-regulated kinase (ERK). Colforsin 99-108 eukaryotic translation initiation factor 4E Mus musculus 172-177 15447679-3 2004 We found that treatment of mouse hippocampal slices with either phorbol ester, to activate PKC, or forskolin, to activate PKA, resulted in activation of Mnk1 and increased eIF4E phosphorylation that was dependent on extracellular signal-regulated kinase (ERK). Colforsin 99-108 mitogen-activated protein kinase 1 Mus musculus 216-253 15447679-3 2004 We found that treatment of mouse hippocampal slices with either phorbol ester, to activate PKC, or forskolin, to activate PKA, resulted in activation of Mnk1 and increased eIF4E phosphorylation that was dependent on extracellular signal-regulated kinase (ERK). Colforsin 99-108 mitogen-activated protein kinase 1 Mus musculus 255-258 15571236-2 2004 Dibutyryl cyclic AMP (dbcAMP), forskolin and glucagon, activating glycogen phosphorylase through activation of protein kinase A (PKA), were found to raise PRPP availability by 44%-56%. Colforsin 31-40 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 111-127 15492464-3 2004 In the presence of forskolin or IBMX (3-isobutyl-1-methylxanthine), ET-1 produced a dual effect, that is, a positive inotropic effect (PIE) and/or a negative inotropic effect (NIE) depending on concentrations of forskolin or IBMX present simultaneously with ET-1. Colforsin 19-28 endothelin 1 Canis lupus familiaris 68-72 15492464-3 2004 In the presence of forskolin or IBMX (3-isobutyl-1-methylxanthine), ET-1 produced a dual effect, that is, a positive inotropic effect (PIE) and/or a negative inotropic effect (NIE) depending on concentrations of forskolin or IBMX present simultaneously with ET-1. Colforsin 19-28 endothelin 1 Canis lupus familiaris 258-262 15492464-3 2004 In the presence of forskolin or IBMX (3-isobutyl-1-methylxanthine), ET-1 produced a dual effect, that is, a positive inotropic effect (PIE) and/or a negative inotropic effect (NIE) depending on concentrations of forskolin or IBMX present simultaneously with ET-1. Colforsin 212-221 endothelin 1 Canis lupus familiaris 68-72 15256533-6 2004 Forskolin plus phorbol myristate acetate also increased promoter activity and, when added to cells cotransfected with PRA, ADAMTS-1 promoter activity increased further. Colforsin 0-9 ADAM metallopeptidase with thrombospondin type 1 motif, 1 Rattus norvegicus 123-131 15571236-2 2004 Dibutyryl cyclic AMP (dbcAMP), forskolin and glucagon, activating glycogen phosphorylase through activation of protein kinase A (PKA), were found to raise PRPP availability by 44%-56%. Colforsin 31-40 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 129-132 15229227-5 2004 Synthetic S. mansoni NPF potently inhibits the forskolin-stimulated accumulation of cAMP in worm homogenates, with significant effects at 10(-11) m. This is the first demonstration of an endogenous inhibition of cAMP by an NPF, and because this is the predominant pathway associated with vertebrate NPY family peptides, it demonstrates a conservation of downstream signaling pathways used by NPFs and NPY peptides. Colforsin 47-56 neuropeptide Y Homo sapiens 299-302 15229227-5 2004 Synthetic S. mansoni NPF potently inhibits the forskolin-stimulated accumulation of cAMP in worm homogenates, with significant effects at 10(-11) m. This is the first demonstration of an endogenous inhibition of cAMP by an NPF, and because this is the predominant pathway associated with vertebrate NPY family peptides, it demonstrates a conservation of downstream signaling pathways used by NPFs and NPY peptides. Colforsin 47-56 neuropeptide Y Homo sapiens 401-404 15234967-11 2004 CFTR(inh)172 caused a small (15%) but significant inhibition of forskolin-stimulated J(lyz) without affecting basal J(lyz). Colforsin 64-73 CF transmembrane conductance regulator Homo sapiens 0-4 15325243-4 2004 In contrast, PKA inhibitors, used at doses that inhibited forskolin-stimulated luciferase activity by 90%, reduced [Ca(+2)](e)-stimulated COX-2 mRNA expression and promoter activity by 80-90%. Colforsin 58-67 prostaglandin-endoperoxide synthase 2 Mus musculus 138-143 15302573-5 2004 Treatment with forskolin, an activator of CREB, significantly attenuated cytochrome c release and Bax translocation in response of serum deprivation. Colforsin 15-24 cAMP responsive element binding protein 1 Homo sapiens 42-46 15302573-5 2004 Treatment with forskolin, an activator of CREB, significantly attenuated cytochrome c release and Bax translocation in response of serum deprivation. Colforsin 15-24 cytochrome c, somatic Homo sapiens 73-85 15302573-5 2004 Treatment with forskolin, an activator of CREB, significantly attenuated cytochrome c release and Bax translocation in response of serum deprivation. Colforsin 15-24 BCL2 associated X, apoptosis regulator Homo sapiens 98-101 15302573-6 2004 In analogy to forskolin treatment, Tax expression results in sustained phosphorylation of CREB at Ser(133) during serum starvation. Colforsin 14-23 cAMP responsive element binding protein 1 Homo sapiens 90-94 15140762-3 2004 Elevation of cAMP with forskolin and IBMX increased VIT32 gene expression with a peak effect at 2 h. The increase in gene expression was abolished by H89 and by actinomycin D, suggesting that cAMP stimulates VIT32 mRNA expression by a PKA-mediated increase in gene transcription. Colforsin 23-32 arginine vasopressin induced 1 Homo sapiens 52-57 15337319-4 2004 The obtained results indicate that transcriptional activity of dopamine D2 receptor gene promoter was dose-dependently increased by retinoic acid, forskolin, rolipram and phorbol 12 myristate 13-acetate, as well as by DMI, CIT and MIA. Colforsin 147-156 dopamine receptor D2 Mus musculus 63-83 15218020-2 2004 Forskolin (34.8 +/- 6.2%) and PTH (29.7 +/- 1.8%) inhibited NHE3 activity in wild-type proximal tubule cells but neither forskolin (-3.2 +/- 3.3%) nor PTH (-16.6 +/- 8.1%) inhibited NHE3 activity in NHERF-1(-/-) cells. Colforsin 0-9 solute carrier family 9 (sodium/hydrogen exchanger), member 3 Mus musculus 60-64 15218020-2 2004 Forskolin (34.8 +/- 6.2%) and PTH (29.7 +/- 1.8%) inhibited NHE3 activity in wild-type proximal tubule cells but neither forskolin (-3.2 +/- 3.3%) nor PTH (-16.6 +/- 8.1%) inhibited NHE3 activity in NHERF-1(-/-) cells. Colforsin 0-9 solute carrier family 9 (sodium/hydrogen exchanger), member 3 Mus musculus 182-186 15218020-2 2004 Forskolin (34.8 +/- 6.2%) and PTH (29.7 +/- 1.8%) inhibited NHE3 activity in wild-type proximal tubule cells but neither forskolin (-3.2 +/- 3.3%) nor PTH (-16.6 +/- 8.1%) inhibited NHE3 activity in NHERF-1(-/-) cells. Colforsin 0-9 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 199-206 15218020-3 2004 Using adenovirus-mediated gene transfer, expression of NHERF-1 in NHERF-1(-/-) proximal tubule cells restored the inhibitory response to forskolin (28.2 +/- 3.0%) and PTH (33.2 +/- 3.9%). Colforsin 137-146 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 55-62 15218020-3 2004 Using adenovirus-mediated gene transfer, expression of NHERF-1 in NHERF-1(-/-) proximal tubule cells restored the inhibitory response to forskolin (28.2 +/- 3.0%) and PTH (33.2 +/- 3.9%). Colforsin 137-146 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Mus musculus 66-73 15666577-6 2004 Leptin at 18 microM increased insulin secretion stimulated by the parasympathetic neurotransmitters acetylcholine (ACh; 10 microM) or vasoactive intestinal peptide (VIP; 10 nM), and by 5 mM theophylline or 2.5 microM forskolin. Colforsin 217-226 leptin Mus musculus 0-6 15126246-3 2004 Our results indicate that ANP(1-28), CNP(1-22), and C-ANF inhibit cAMP synthesis directly stimulated by forskolin or by the physiological agonists histamine and 5-hydroxytryptamine. Colforsin 104-113 natriuretic peptide C Rattus norvegicus 37-40 15140762-3 2004 Elevation of cAMP with forskolin and IBMX increased VIT32 gene expression with a peak effect at 2 h. The increase in gene expression was abolished by H89 and by actinomycin D, suggesting that cAMP stimulates VIT32 mRNA expression by a PKA-mediated increase in gene transcription. Colforsin 23-32 arginine vasopressin induced 1 Homo sapiens 208-213 15155571-9 2004 When the cells were treated with forskolin, translocation of AQP2 to the apical membrane was observed. Colforsin 33-42 aquaporin 2 Canis lupus familiaris 61-65 15481297-13 2004 Forskolin almost completely blocked TNF release stimulated by LPS or ROS. Colforsin 0-9 tumor necrosis factor Rattus norvegicus 36-39 15306227-8 2004 In addition, receptor-dependent and -independent functions of Gialpha proteins were attenuated in hyperglycemic cells, as demonstrated by inhibition of forskolin (FSK)-stimulated adenylyl cyclase activity by low concentration of GTPgammaS or by angiotensin II (Ang II), oxotremorine or C-ANP(4-23) (a ring deleted analog of atrial natriuretic peptide). Colforsin 152-161 angiotensinogen Rattus norvegicus 245-259 15306227-8 2004 In addition, receptor-dependent and -independent functions of Gialpha proteins were attenuated in hyperglycemic cells, as demonstrated by inhibition of forskolin (FSK)-stimulated adenylyl cyclase activity by low concentration of GTPgammaS or by angiotensin II (Ang II), oxotremorine or C-ANP(4-23) (a ring deleted analog of atrial natriuretic peptide). Colforsin 152-161 angiotensinogen Rattus norvegicus 261-267 15306227-8 2004 In addition, receptor-dependent and -independent functions of Gialpha proteins were attenuated in hyperglycemic cells, as demonstrated by inhibition of forskolin (FSK)-stimulated adenylyl cyclase activity by low concentration of GTPgammaS or by angiotensin II (Ang II), oxotremorine or C-ANP(4-23) (a ring deleted analog of atrial natriuretic peptide). Colforsin 163-166 angiotensinogen Rattus norvegicus 245-259 15306227-8 2004 In addition, receptor-dependent and -independent functions of Gialpha proteins were attenuated in hyperglycemic cells, as demonstrated by inhibition of forskolin (FSK)-stimulated adenylyl cyclase activity by low concentration of GTPgammaS or by angiotensin II (Ang II), oxotremorine or C-ANP(4-23) (a ring deleted analog of atrial natriuretic peptide). Colforsin 163-166 angiotensinogen Rattus norvegicus 261-267 15231818-9 2004 Following AC(VI) gene transfer, when cardiac myocytes were stimulated with isoproterenol or NKH477, a water-soluble forskolin analog that directly stimulates AC, expression of ATF3 protein was increased even more, which correlated with reduced expression of PLB. Colforsin 92-98 adenylate cyclase 6 Rattus norvegicus 10-16 15231818-9 2004 Following AC(VI) gene transfer, when cardiac myocytes were stimulated with isoproterenol or NKH477, a water-soluble forskolin analog that directly stimulates AC, expression of ATF3 protein was increased even more, which correlated with reduced expression of PLB. Colforsin 92-98 activating transcription factor 3 Rattus norvegicus 176-180 15231818-9 2004 Following AC(VI) gene transfer, when cardiac myocytes were stimulated with isoproterenol or NKH477, a water-soluble forskolin analog that directly stimulates AC, expression of ATF3 protein was increased even more, which correlated with reduced expression of PLB. Colforsin 92-98 phospholamban Rattus norvegicus 258-261 15231818-9 2004 Following AC(VI) gene transfer, when cardiac myocytes were stimulated with isoproterenol or NKH477, a water-soluble forskolin analog that directly stimulates AC, expression of ATF3 protein was increased even more, which correlated with reduced expression of PLB. Colforsin 116-125 activating transcription factor 3 Rattus norvegicus 176-180 15155571-10 2004 Washout of forskolin induced retrieval of AQP2 into the cytoplasm, and AQP2 was transiently colocalized with EEA1-positive endosomes. Colforsin 11-20 aquaporin 2 Canis lupus familiaris 42-46 15213229-11 2004 Forskolin, an activator of adenyl cyclase, increased COX-2 promoter activity via the CREB site. Colforsin 0-9 cAMP responsive element binding protein 1 Mus musculus 85-89 15350253-10 2004 Coexposure of the cells to forskolin and A23187 produced an additive effect on stimulated release of GnRH. Colforsin 27-36 gonadotropin releasing hormone 1 Homo sapiens 101-105 15350253-11 2004 Cells exposed to 1 microM of forskolin (an activator of adenylate cyclase) for 5 minutes showed a 2.6-fold increase in GnRH release. Colforsin 29-38 gonadotropin releasing hormone 1 Homo sapiens 119-123 15292653-7 2004 Furthermore, hNmU inhibited forskolin (3 micromol/l)-stimulated accumulation of cAMP in intact HEK-293 cells expressing either NmU1R or NmU2R. Colforsin 28-37 neuromedin U Homo sapiens 13-17 15292653-7 2004 Furthermore, hNmU inhibited forskolin (3 micromol/l)-stimulated accumulation of cAMP in intact HEK-293 cells expressing either NmU1R or NmU2R. Colforsin 28-37 neuromedin U receptor 1 Homo sapiens 127-132 15292653-7 2004 Furthermore, hNmU inhibited forskolin (3 micromol/l)-stimulated accumulation of cAMP in intact HEK-293 cells expressing either NmU1R or NmU2R. Colforsin 28-37 neuromedin U Homo sapiens 136-141 15279909-7 2004 We also found a marked decrease on Cch-stimulated Ca2+ mobilization in pretreated FRT cells with forskolin, an activator of protein kinase A (PKA), but the preincubation of cells with genistein, an inhibitor of protein tyrosine kinases, had no effect on Ca2+ mobilization induced by Cch. Colforsin 97-106 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 124-140 15279909-7 2004 We also found a marked decrease on Cch-stimulated Ca2+ mobilization in pretreated FRT cells with forskolin, an activator of protein kinase A (PKA), but the preincubation of cells with genistein, an inhibitor of protein tyrosine kinases, had no effect on Ca2+ mobilization induced by Cch. Colforsin 97-106 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 142-145 15312183-5 2004 Finally, the A2AR agonist CGS 21680 potentiated CHGP effects, an action that was reproduced and abolished, respectively, by forskolin (an activator of the cAMP/protein kinase A, PKA, pathway) and KT 5720 (a PKA inhibitor). Colforsin 124-133 adenosine A2a receptor Rattus norvegicus 13-17 15306199-5 2004 Agonist activity determined by inhibition of forskolin-induced cAMP in Chinese hamster ovary cells transfected with the human dopamine D(4.4) receptor (EC(50)=7.5 nM, intrinsic activity=0.71) indicates that A-369508 is a potent agonist at the human dopamine D(4) receptor. Colforsin 45-54 dopamine receptor D4 Homo sapiens 249-271 15294019-13 2004 The invasive ability of trophoblast cells, induced by forskolin, was reduced by MMP-2 antibody in: JAR cells, 6-8 w and 9-12 w trophoblasts. Colforsin 54-63 matrix metallopeptidase 2 Homo sapiens 80-85 15087429-5 2004 Forskolin (FSK), an adenylate cyclase inducer, 8-bromo-cAMP, a cAMP analog, and phorbol myristate acetate, a PKC activator, increased E4bp4 mRNA levels, whereas ionomycin, a calcium ionophore, had no effect. Colforsin 0-9 nuclear factor, interleukin 3, regulated Mus musculus 134-139 15087429-5 2004 Forskolin (FSK), an adenylate cyclase inducer, 8-bromo-cAMP, a cAMP analog, and phorbol myristate acetate, a PKC activator, increased E4bp4 mRNA levels, whereas ionomycin, a calcium ionophore, had no effect. Colforsin 11-14 nuclear factor, interleukin 3, regulated Mus musculus 134-139 15087429-6 2004 Pretreatment of cells with 30 microm H89, a PKA inhibitor, strongly inhibited PTH- and FSK-induced E4bp4 expression. Colforsin 87-90 nuclear factor, interleukin 3, regulated Mus musculus 99-104 15180965-7 2004 The effect of PGE2 is mediated through the specific receptors EP2/4 and is mimicked by cAMP-inducing agents, such as forskolin and dbcAMP. Colforsin 117-126 prostaglandin E receptor 2 Homo sapiens 62-67 15242814-4 2004 Both the forskolin and the N(6)-monobutyryl cAMP activated PDE4 activities were blocked by the PKA-specific inhibitor, H89. Colforsin 9-18 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 95-98 15242814-5 2004 This forskolin-stimulated and PKA-mediated short-term activation of PDE4 activity was further confirmed by in vitro phosphorylation of 87kDa PDE4A6 and 83kDa PDE4B3 polypeptides using exogenous PKA Calpha. Colforsin 5-14 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 30-33 15242814-5 2004 This forskolin-stimulated and PKA-mediated short-term activation of PDE4 activity was further confirmed by in vitro phosphorylation of 87kDa PDE4A6 and 83kDa PDE4B3 polypeptides using exogenous PKA Calpha. Colforsin 5-14 phosphodiesterase 4B Rattus norvegicus 158-164 15242814-5 2004 This forskolin-stimulated and PKA-mediated short-term activation of PDE4 activity was further confirmed by in vitro phosphorylation of 87kDa PDE4A6 and 83kDa PDE4B3 polypeptides using exogenous PKA Calpha. Colforsin 5-14 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 194-204 15305856-9 2004 Exposure of astrocyte cultures to the differentiating agent forskolin resulted in up-regulation of bystin followed by a pronounced astrocytic stellation. Colforsin 60-69 bystin-like Rattus norvegicus 99-105 15496596-0 2004 Effect of forskolin on synaptotagmin IV protein trafficking in PC12 cells. Colforsin 10-19 synaptotagmin 4 Rattus norvegicus 23-39 15496596-2 2004 In this study, we investigated the transport mechanism of Syt IV protein induced by forskolin and found that forskolin treatment dramatically increases the Syt IV protein level (approximately 10-fold, to a level comparable to that of Syt IX) and promotes the transport of Syt IV protein from the Golgi to the cell periphery by a microtubule-dependent motor(s). Colforsin 109-118 synaptotagmin 4 Rattus norvegicus 156-162 15496596-1 2004 Synaptotagmin IV (Syt IV) was originally described as an immediate early gene product induced by forskolin or membrane depolarization in PC12 cells; however, nothing is known about the subcellular localization and transport of the newly translated Syt IV protein in PC12 cells. Colforsin 97-106 synaptotagmin 4 Rattus norvegicus 0-16 15496596-1 2004 Synaptotagmin IV (Syt IV) was originally described as an immediate early gene product induced by forskolin or membrane depolarization in PC12 cells; however, nothing is known about the subcellular localization and transport of the newly translated Syt IV protein in PC12 cells. Colforsin 97-106 synaptotagmin 4 Rattus norvegicus 18-24 15496596-2 2004 In this study, we investigated the transport mechanism of Syt IV protein induced by forskolin and found that forskolin treatment dramatically increases the Syt IV protein level (approximately 10-fold, to a level comparable to that of Syt IX) and promotes the transport of Syt IV protein from the Golgi to the cell periphery by a microtubule-dependent motor(s). Colforsin 84-93 synaptotagmin 4 Rattus norvegicus 58-64 15496596-2 2004 In this study, we investigated the transport mechanism of Syt IV protein induced by forskolin and found that forskolin treatment dramatically increases the Syt IV protein level (approximately 10-fold, to a level comparable to that of Syt IX) and promotes the transport of Syt IV protein from the Golgi to the cell periphery by a microtubule-dependent motor(s). Colforsin 109-118 synaptotagmin 4 Rattus norvegicus 58-64 15496596-4 2004 Immunoelectron microscopic analysis showed that some Syt IV signals are clearly associated with dense-core vesicles in forskolin-treated PC12 cells, although the majority of the Syt IV molecules at the cell periphery were present on clear vesicular structures other than dense-core vesicles. Colforsin 119-128 synaptotagmin 4 Rattus norvegicus 53-59 15496596-5 2004 An N-terminal antibody-uptake experiment indicated that Syt IV-containing vesicles in forskolin-treated PC12 cells undergo Ca(2+)-dependent exocytosis, because uptake of the anti-Syt IV-N antibody from the culture medium was slightly, but significantly, increased after forskolin treatment. Colforsin 86-95 synaptotagmin 4 Rattus norvegicus 56-62 15496596-5 2004 An N-terminal antibody-uptake experiment indicated that Syt IV-containing vesicles in forskolin-treated PC12 cells undergo Ca(2+)-dependent exocytosis, because uptake of the anti-Syt IV-N antibody from the culture medium was slightly, but significantly, increased after forskolin treatment. Colforsin 86-95 synaptotagmin 4 Rattus norvegicus 179-185 15496596-2 2004 In this study, we investigated the transport mechanism of Syt IV protein induced by forskolin and found that forskolin treatment dramatically increases the Syt IV protein level (approximately 10-fold, to a level comparable to that of Syt IX) and promotes the transport of Syt IV protein from the Golgi to the cell periphery by a microtubule-dependent motor(s). Colforsin 109-118 synaptotagmin 4 Rattus norvegicus 156-162 15496596-5 2004 An N-terminal antibody-uptake experiment indicated that Syt IV-containing vesicles in forskolin-treated PC12 cells undergo Ca(2+)-dependent exocytosis, because uptake of the anti-Syt IV-N antibody from the culture medium was slightly, but significantly, increased after forskolin treatment. Colforsin 270-279 synaptotagmin 4 Rattus norvegicus 56-62 15496596-2 2004 In this study, we investigated the transport mechanism of Syt IV protein induced by forskolin and found that forskolin treatment dramatically increases the Syt IV protein level (approximately 10-fold, to a level comparable to that of Syt IX) and promotes the transport of Syt IV protein from the Golgi to the cell periphery by a microtubule-dependent motor(s). Colforsin 109-118 synaptotagmin 5 Rattus norvegicus 234-240 15496596-6 2004 Our results indicate that forskolin (or the increased cAMP level) is important for the transport of the Syt IV protein from the Golgi to the cell periphery, but not sufficient for the sorting of all Syt IV molecules to mature dense-core vesicles. Colforsin 26-35 synaptotagmin 4 Rattus norvegicus 104-110 15240680-7 2004 Inhibition of STAT5a/b phosphorylation was reproduced with cell-permeable 8-bromo-cAMP or forskolin-induced activation of adenylyl cyclase, and blocked by the cAMP/protein kinase A inhibitor Rp-cAMP. Colforsin 90-99 signal transducer and activator of transcription 5A Mus musculus 14-20 15250941-13 2004 Stable or transient expression of wild-type MC1R, but not of loss-of-function mutants, potently stimulates forskolin activation of adenylyl cyclase, a common feature of constitutively active Gs-coupled receptors. Colforsin 107-116 melanocortin 1 receptor Homo sapiens 44-48 15211591-7 2004 In contrast, BACE1 expression was suppressed by stimulation of M2-mediated pathways via selective M2-agonist binding or direct activation of adenylate cyclase with forskolin, an effect that was prevented by inhibiting protein kinase A. Colforsin 164-173 beta-secretase 1 Homo sapiens 13-18 15240680-8 2004 Forskolin and 8-bromo-cAMP also induced SHP-2 tyrosine phosphorylation. Colforsin 0-9 protein tyrosine phosphatase, non-receptor type 11 Mus musculus 40-45 15194485-2 2004 Calu-3 monolayers responded to forskolin, a cystic fibrosis transmembrane regulator (CFTR) channel agonist, by secreting a significant amount of ASF. Colforsin 31-40 CF transmembrane conductance regulator Homo sapiens 44-83 15194485-2 2004 Calu-3 monolayers responded to forskolin, a cystic fibrosis transmembrane regulator (CFTR) channel agonist, by secreting a significant amount of ASF. Colforsin 31-40 CF transmembrane conductance regulator Homo sapiens 85-89 15225617-3 2004 In addition, cAMP analogs (8-Bromo-cAMP) and forskolin (an adenylate cyclase activator) also reduced TGFbeta1-induced in vitro angiogenesis in mouse endothelial cell lines and in primary cultures of human umbilical vein endothelial cells on collagen gels. Colforsin 45-54 transforming growth factor, beta 1 Mus musculus 101-109 15207912-7 2004 Additionally, forskolin-induced transcription was inhibited by a dominant-negative mutant of CRE-binding protein (CREB) in CATH.a cells. Colforsin 14-23 cAMP responsive element binding protein 1 Mus musculus 93-112 15207912-7 2004 Additionally, forskolin-induced transcription was inhibited by a dominant-negative mutant of CRE-binding protein (CREB) in CATH.a cells. Colforsin 14-23 cAMP responsive element binding protein 1 Mus musculus 114-118 15225617-6 2004 Thus, Smad2 was normally phosphorylated and translocated to the nucleus in the presence of forskolin. Colforsin 91-100 SMAD family member 2 Homo sapiens 6-11 14975937-5 2004 A Grb2-SOS inhibitor (SH3 binding peptide), an Ras inhibitor (farnesyl transferase inhibitor 277), and an Raf-1 inhibitor (forskolin) each prevented FGF-10- and H2O2-induced A549 cell ERK1/2 phosphorylation. Colforsin 123-132 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 106-111 14975937-5 2004 A Grb2-SOS inhibitor (SH3 binding peptide), an Ras inhibitor (farnesyl transferase inhibitor 277), and an Raf-1 inhibitor (forskolin) each prevented FGF-10- and H2O2-induced A549 cell ERK1/2 phosphorylation. Colforsin 123-132 fibroblast growth factor 10 Rattus norvegicus 149-155 15044357-6 2004 Interestingly, administration of the activator of adenylate cyclase, forskolin, decreased GHRH-R mRNA levels but had no effect on GHS-R, thus suggesting a distinct contribution of the various intracellular signals operating in somatotropes to the regulation of the expression of these receptors. Colforsin 69-78 growth hormone releasing hormone receptor Homo sapiens 90-96 15241559-6 2004 Acute stimulation with thyroid-stimulating hormone (TSH) or forskolin prevents all signs of accelerated E-cadherin turnover. Colforsin 60-69 cadherin 1 Sus scrofa 104-114 15130921-5 2004 METHODS AND RESULTS: Activation of Ral was observed 15 to 20 minutes after stimulation of endothelial cells with epinephrine, forskolin, or dibutyryl-cAMP. Colforsin 126-135 RAS like proto-oncogene A Homo sapiens 35-38 14992682-8 2004 Fsk or PD98059 also inhibited protein expression of PCNA and blocked a decrease in p27 protein. Colforsin 0-3 proliferating cell nuclear antigen Homo sapiens 52-56 14992682-8 2004 Fsk or PD98059 also inhibited protein expression of PCNA and blocked a decrease in p27 protein. Colforsin 0-3 interferon alpha inducible protein 27 Homo sapiens 83-86 14992682-9 2004 Fsk induced the phosphorylation of Raf-1 at Ser259, which was inhibited by KT5720. Colforsin 0-3 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 35-40 15272208-6 2004 H-89, a protein kinase A (PKA) inhibitor, inhibited 5-HT-, RS 67506-, and RS 67333-induced depolarizations, while forskolin (10 microM), an activator of adenylate cyclase, induced depolarization. Colforsin 114-123 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 26-29 15243700-7 2004 In contrast, IAPP promoter activity was doubled after incubation with forskolin or dexamethasone, regardless of the glucose concentrations in the culture media. Colforsin 70-79 islet amyloid polypeptide Homo sapiens 13-17 15294060-11 2004 In addition, IL-8 pretreated cells revealed a marked decrease in PKA activity when cells were stimulated with forskolin (FSK; 10 microM). Colforsin 110-119 C-X-C motif chemokine ligand 8 Bos taurus 13-17 15294060-11 2004 In addition, IL-8 pretreated cells revealed a marked decrease in PKA activity when cells were stimulated with forskolin (FSK; 10 microM). Colforsin 121-124 C-X-C motif chemokine ligand 8 Bos taurus 13-17 15112327-13 2004 Adding HGF suppressed the forskolin-induced steroidogenic acute regulatory protein (StAR) expression, which is a key regulator in progesterone synthesis. Colforsin 26-35 hepatocyte growth factor Homo sapiens 7-10 15112327-13 2004 Adding HGF suppressed the forskolin-induced steroidogenic acute regulatory protein (StAR) expression, which is a key regulator in progesterone synthesis. Colforsin 26-35 steroidogenic acute regulatory protein Homo sapiens 84-88 15187422-7 2004 Furthermore, MIC markedly suppressed alpha-melanocyte stimulating hormone or forskolin-induced tyrosinase activity in B16 cells. Colforsin 77-86 tyrosinase Mus musculus 95-105 15196920-2 2004 Here, we demonstrate that serine 267 in the homeodomain of En-2 is phosphorylated by protein kinase A (PKA) in forskolin-treated COS-7 cells. Colforsin 111-120 engrailed homeobox 2 Homo sapiens 59-63 15170357-6 2004 nNOS was upregulated by other stable analogues of cAMP, by the activator of adenylyl cyclase forskolin, by isoproterenol or by dopamine through activation of D1 receptors, and by inhibitors of phosphodiesterase. Colforsin 93-102 nitric oxide synthase 1 Homo sapiens 0-4 15135301-2 2004 The drugs tested were found to exhibit inverse agonist activity at the D(2) dopamine receptor based on their effects to potentiate forskolin-stimulated cyclic AMP (cAMP) accumulation. Colforsin 131-140 D(2) dopamine receptor Cricetulus griseus 71-93 15234351-3 2004 Here, we show that forskolin (Fk) rapidly stimulates the expression of both the full-length and truncated trkB isoforms in primary cultures of cortical neurons. Colforsin 19-28 neurotrophic receptor tyrosine kinase 2 Homo sapiens 106-110 15178447-5 2004 Here, we show that phosphorylation of ICBP90 through the cAMP signaling pathway accelerates exit of forskolin-treated cells from the G1 phase and increases binding of ICBP90 to the ICB2 element of the TopoIIalpha gene promoter with a subsequent increase of TopoIIalpha expression. Colforsin 100-109 ubiquitin like with PHD and ring finger domains 1 Homo sapiens 38-44 15178447-5 2004 Here, we show that phosphorylation of ICBP90 through the cAMP signaling pathway accelerates exit of forskolin-treated cells from the G1 phase and increases binding of ICBP90 to the ICB2 element of the TopoIIalpha gene promoter with a subsequent increase of TopoIIalpha expression. Colforsin 100-109 ubiquitin like with PHD and ring finger domains 1 Homo sapiens 167-173 15093612-6 2004 RGS2 and RGS7 significantly decreased Galphaq-mediated signaling by 5-HT2A receptors, confirming that the RGS4 and RGS10 effects on forskolin-stimulated cAMP production were specific, and not simply due to overexpression. Colforsin 132-141 regulator of G protein signaling 2 Homo sapiens 0-4 15093612-4 2004 Additionally, RGS4 and RGS10 significantly inhibited forskolin-stimulated cAMP production in both cell lines. Colforsin 53-62 regulator of G protein signaling 4 Homo sapiens 14-18 15093612-6 2004 RGS2 and RGS7 significantly decreased Galphaq-mediated signaling by 5-HT2A receptors, confirming that the RGS4 and RGS10 effects on forskolin-stimulated cAMP production were specific, and not simply due to overexpression. Colforsin 132-141 5-hydroxytryptamine receptor 2A Homo sapiens 68-74 15093612-4 2004 Additionally, RGS4 and RGS10 significantly inhibited forskolin-stimulated cAMP production in both cell lines. Colforsin 53-62 regulator of G protein signaling 10 Homo sapiens 23-28 15093612-6 2004 RGS2 and RGS7 significantly decreased Galphaq-mediated signaling by 5-HT2A receptors, confirming that the RGS4 and RGS10 effects on forskolin-stimulated cAMP production were specific, and not simply due to overexpression. Colforsin 132-141 regulator of G protein signaling 4 Homo sapiens 106-110 15093612-6 2004 RGS2 and RGS7 significantly decreased Galphaq-mediated signaling by 5-HT2A receptors, confirming that the RGS4 and RGS10 effects on forskolin-stimulated cAMP production were specific, and not simply due to overexpression. Colforsin 132-141 regulator of G protein signaling 10 Homo sapiens 115-120 15033909-4 2004 In pituitary cells, forskolin (FSK) stimulates ERalpha transcription through the protein kinase A (PKA) pathway. Colforsin 20-29 estrogen receptor 1 Homo sapiens 47-54 15135319-8 2004 Forskolin enhanced and DDA blocked the production of IL-1beta by PGE2. Colforsin 0-9 interleukin 1 beta Mus musculus 53-61 15135319-12 2004 Among the potential agonists, forskolin was a potent inducer of IL-1beta expression, while phorbol myristate acetate and serum had little effect. Colforsin 30-39 interleukin 1 beta Mus musculus 64-72 15138589-8 2004 By contrast, we found that isoproterenol had no effect on A549 cells whereas forskolin significantly inhibited DNA synthesis and ERK1/2 activity. Colforsin 77-86 mitogen-activated protein kinase 3 Homo sapiens 129-135 15033909-4 2004 In pituitary cells, forskolin (FSK) stimulates ERalpha transcription through the protein kinase A (PKA) pathway. Colforsin 31-34 estrogen receptor 1 Homo sapiens 47-54 15033909-7 2004 In contrast, FSK stimulated ERalpha transcription without decreasing ERalpha protein. Colforsin 13-16 estrogen receptor 1 Homo sapiens 28-35 15033909-8 2004 Treatment with FSK plus E2 resulted in synergistic ERalpha transactivation, and FSK specifically prevented E2-induced ERalpha degradation. Colforsin 15-18 estrogen receptor 1 Homo sapiens 51-58 15033909-8 2004 Treatment with FSK plus E2 resulted in synergistic ERalpha transactivation, and FSK specifically prevented E2-induced ERalpha degradation. Colforsin 80-83 estrogen receptor 1 Homo sapiens 118-125 15033909-12 2004 FSK prevented all ligand-induced ERalpha degradation. Colforsin 0-3 estrogen receptor 1 Homo sapiens 33-40 15047863-5 2004 CIP4 is phosphorylated by protein kinase A in vitro, and elevation of intracellular cyclic AMP with forskolin stimulates in situ phosphorylation of CIP4. Colforsin 100-109 thyroid hormone receptor interactor 10 Homo sapiens 148-152 15155837-6 2004 In cultured smooth muscle cells from rat aorta, forskolin induced a rapid increase in Fos/p-Fos protein levels and activator protein 1 (AP-1) binding activity. Colforsin 48-57 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 86-89 15155837-6 2004 In cultured smooth muscle cells from rat aorta, forskolin induced a rapid increase in Fos/p-Fos protein levels and activator protein 1 (AP-1) binding activity. Colforsin 48-57 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 92-95 15207283-5 2004 Addition of forskolin to the media induces an additional stimulation of PMP22 expression and results in an impairment of cells migration and motility, and a reduction of cell area and perimeter. Colforsin 12-21 peripheral myelin protein 22 Homo sapiens 72-77 15155837-6 2004 In cultured smooth muscle cells from rat aorta, forskolin induced a rapid increase in Fos/p-Fos protein levels and activator protein 1 (AP-1) binding activity. Colforsin 48-57 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 115-134 15155837-6 2004 In cultured smooth muscle cells from rat aorta, forskolin induced a rapid increase in Fos/p-Fos protein levels and activator protein 1 (AP-1) binding activity. Colforsin 48-57 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 136-140 15155837-7 2004 Inhibition of this transcription factor by an AP-1 decoy prevented the forskolin-induced down-regulation of HuR. Colforsin 71-80 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 46-50 15155837-7 2004 Inhibition of this transcription factor by an AP-1 decoy prevented the forskolin-induced down-regulation of HuR. Colforsin 71-80 ELAV like RNA binding protein 1 Rattus norvegicus 108-111 15155837-8 2004 We conclude that forskolin/cAMP decrease the expression of heterodimeric sGC in rat aortic smooth muscle cells via activation of Fos/AP-1, which decreases the expression of HuR and thus destabilizes the sGCalpha1 and beta1 mRNA. Colforsin 17-26 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 73-76 15155837-8 2004 We conclude that forskolin/cAMP decrease the expression of heterodimeric sGC in rat aortic smooth muscle cells via activation of Fos/AP-1, which decreases the expression of HuR and thus destabilizes the sGCalpha1 and beta1 mRNA. Colforsin 17-26 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 129-132 15155837-8 2004 We conclude that forskolin/cAMP decrease the expression of heterodimeric sGC in rat aortic smooth muscle cells via activation of Fos/AP-1, which decreases the expression of HuR and thus destabilizes the sGCalpha1 and beta1 mRNA. Colforsin 17-26 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 133-137 15155837-8 2004 We conclude that forskolin/cAMP decrease the expression of heterodimeric sGC in rat aortic smooth muscle cells via activation of Fos/AP-1, which decreases the expression of HuR and thus destabilizes the sGCalpha1 and beta1 mRNA. Colforsin 17-26 ELAV like RNA binding protein 1 Rattus norvegicus 173-176 15155843-4 2004 The heterologous internalization of the mGluR1 splice variants triggered by carbachol was also inhibited by isoprenaline and forskolin in a PKA-sensitive fashion, whereas the constitutive (agonist-independent) internalization of mGluR1a was inhibited only modestly by PKA activation. Colforsin 125-134 glutamate metabotropic receptor 1 Homo sapiens 40-46 15155843-7 2004 In coimmunoprecipitation experiments, the ability of glutamate to increase association of GRK2 and arrestin-2 with mGluR1a and mGluR1b was inhibited by PKA activation with forskolin. Colforsin 172-181 G protein-coupled receptor kinase 2 Homo sapiens 90-94 15155843-7 2004 In coimmunoprecipitation experiments, the ability of glutamate to increase association of GRK2 and arrestin-2 with mGluR1a and mGluR1b was inhibited by PKA activation with forskolin. Colforsin 172-181 arrestin beta 1 Homo sapiens 99-109 15196703-5 2004 Forskolin, a direct activator of adenylyl cyclase, elicited the phosphorylation of SAPK/JNK, and 8bromo-cAMP, a plasma membrane-permeable cAMP analogue-stimulated VEGF synthesis was significantly reduced by SP600125. Colforsin 0-9 vascular endothelial growth factor A Mus musculus 163-167 15047694-6 2004 Oocytes co-injected with both CFTR and mENaC or hENaC expressed an amiloride-sensitive whole cell current that was decreased compared with that observed with the injection of mENaC or hENaC alone before CFTR activation with forskolin/3-isobutyl-1-methylxanthine. Colforsin 224-233 cystic fibrosis transmembrane conductance regulator Mus musculus 30-34 15047694-6 2004 Oocytes co-injected with both CFTR and mENaC or hENaC expressed an amiloride-sensitive whole cell current that was decreased compared with that observed with the injection of mENaC or hENaC alone before CFTR activation with forskolin/3-isobutyl-1-methylxanthine. Colforsin 224-233 sodium channel, nonvoltage-gated 1 alpha Mus musculus 39-44 15047694-6 2004 Oocytes co-injected with both CFTR and mENaC or hENaC expressed an amiloride-sensitive whole cell current that was decreased compared with that observed with the injection of mENaC or hENaC alone before CFTR activation with forskolin/3-isobutyl-1-methylxanthine. Colforsin 224-233 cystic fibrosis transmembrane conductance regulator Mus musculus 203-207 15037633-5 2004 In addition, beta-alanine decreased forskolin-stimulated cAMP production in cells expressing TGR7, suggesting that TGR7 couples with G proteins Gq and Gi. Colforsin 36-45 MAS related GPR family member D Rattus norvegicus 93-97 15037633-5 2004 In addition, beta-alanine decreased forskolin-stimulated cAMP production in cells expressing TGR7, suggesting that TGR7 couples with G proteins Gq and Gi. Colforsin 36-45 MAS related GPR family member D Rattus norvegicus 115-119 14736704-0 2004 Novel regulation by Rac1 of glucose- and forskolin-induced insulin secretion in INS-1 beta-cells. Colforsin 41-50 Rac family small GTPase 1 Rattus norvegicus 20-24 15044443-10 2004 In myocytes, insulin increased, while epinephrine, isoproterenol, and forskolin reduced musclin mRNA, all of which are known to increase the cellular content of cyclic AMP, a counter-regulator to insulin. Colforsin 70-79 osteocrin Mus musculus 88-95 14684377-5 2004 Moreover, stimulation of T84 cells with SDF-1/CXCL12 inhibited cAMP production in response to the adenylyl cyclase activator forskolin, and this inhibition was abrogated by either anti-CXCR4 antibody or receptor desensitization. Colforsin 125-134 C-X-C motif chemokine ligand 12 Homo sapiens 40-45 14684377-5 2004 Moreover, stimulation of T84 cells with SDF-1/CXCL12 inhibited cAMP production in response to the adenylyl cyclase activator forskolin, and this inhibition was abrogated by either anti-CXCR4 antibody or receptor desensitization. Colforsin 125-134 C-X-C motif chemokine ligand 12 Homo sapiens 46-52 14684377-5 2004 Moreover, stimulation of T84 cells with SDF-1/CXCL12 inhibited cAMP production in response to the adenylyl cyclase activator forskolin, and this inhibition was abrogated by either anti-CXCR4 antibody or receptor desensitization. Colforsin 125-134 C-X-C motif chemokine receptor 4 Homo sapiens 185-190 14684377-7 2004 Consistent with the inhibition of forskolin-stimulated cAMP production, SDF-1/CXCL12 also inhibited forskolin-induced ion transport in voltage-clamped polarized T84 cells. Colforsin 34-43 C-X-C motif chemokine ligand 12 Homo sapiens 78-84 14684377-7 2004 Consistent with the inhibition of forskolin-stimulated cAMP production, SDF-1/CXCL12 also inhibited forskolin-induced ion transport in voltage-clamped polarized T84 cells. Colforsin 100-109 C-X-C motif chemokine ligand 12 Homo sapiens 72-77 14684377-7 2004 Consistent with the inhibition of forskolin-stimulated cAMP production, SDF-1/CXCL12 also inhibited forskolin-induced ion transport in voltage-clamped polarized T84 cells. Colforsin 100-109 C-X-C motif chemokine ligand 12 Homo sapiens 78-84 15112053-2 2004 Here we report that (i) EDF-1 is in vitro and in vivo phosphorylated by protein kinase A (PKA); (ii) EDF-1/CaM interaction is modulated by the phosphorylation of EDF-1 by PKA; (iii) forskolin stimulates nuclear accumulation of EDF-1, and (iv) PKA phosphorylation enhances EDF-1 interaction with the TATA-binding protein. Colforsin 182-191 endothelial differentiation related factor 1 Homo sapiens 24-29 15112053-2 2004 Here we report that (i) EDF-1 is in vitro and in vivo phosphorylated by protein kinase A (PKA); (ii) EDF-1/CaM interaction is modulated by the phosphorylation of EDF-1 by PKA; (iii) forskolin stimulates nuclear accumulation of EDF-1, and (iv) PKA phosphorylation enhances EDF-1 interaction with the TATA-binding protein. Colforsin 182-191 endothelial differentiation related factor 1 Homo sapiens 101-106 15112053-2 2004 Here we report that (i) EDF-1 is in vitro and in vivo phosphorylated by protein kinase A (PKA); (ii) EDF-1/CaM interaction is modulated by the phosphorylation of EDF-1 by PKA; (iii) forskolin stimulates nuclear accumulation of EDF-1, and (iv) PKA phosphorylation enhances EDF-1 interaction with the TATA-binding protein. Colforsin 182-191 endothelial differentiation related factor 1 Homo sapiens 101-106 15112053-2 2004 Here we report that (i) EDF-1 is in vitro and in vivo phosphorylated by protein kinase A (PKA); (ii) EDF-1/CaM interaction is modulated by the phosphorylation of EDF-1 by PKA; (iii) forskolin stimulates nuclear accumulation of EDF-1, and (iv) PKA phosphorylation enhances EDF-1 interaction with the TATA-binding protein. Colforsin 182-191 endothelial differentiation related factor 1 Homo sapiens 101-106 15112053-2 2004 Here we report that (i) EDF-1 is in vitro and in vivo phosphorylated by protein kinase A (PKA); (ii) EDF-1/CaM interaction is modulated by the phosphorylation of EDF-1 by PKA; (iii) forskolin stimulates nuclear accumulation of EDF-1, and (iv) PKA phosphorylation enhances EDF-1 interaction with the TATA-binding protein. Colforsin 182-191 endothelial differentiation related factor 1 Homo sapiens 101-106 15193767-3 2004 The addition of 10 microM forskolin increased the number of DAergic neurons, cooperating with 50 ng/ml FGF8. Colforsin 26-35 fibroblast growth factor 8 Homo sapiens 103-107 15007069-5 2004 Using neonatal rat cardiac myocytes, we found that disruption of lipid rafts with beta-cyclodextrin inhibited forskolin-stimulated AC activity and cAMP production, eliminated caveolin-3-eNOS interaction, and increased NO production. Colforsin 110-119 caveolin 3 Rattus norvegicus 175-185 15007069-7 2004 An NO donor, SNAP, inhibited basal and forskolin-stimulated cAMP production in both native cardiac myocytes and cardiac myocytes and pulmonary artery endothelial cells engineered to overexpress AC6. Colforsin 39-48 adenylate cyclase 6 Homo sapiens 194-197 15140627-3 2004 Forskolin-activated ICl(CFTR) was inhibited by reference blocker anthracene-9-carboxylic acid but unaffected by < or = 200 microM dideoxyforskolin and verapamil. Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Oryctolagus cuniculus 24-28 14736704-6 2004 Expression of a dominant-negative Rac1 mutant (N17Rac1) abolished glucose-induced translocation of Rac1 and significantly inhibited insulin secretion stimulated by glucose and forskolin. Colforsin 176-185 Rac family small GTPase 1 Rattus norvegicus 34-38 14736704-6 2004 Expression of a dominant-negative Rac1 mutant (N17Rac1) abolished glucose-induced translocation of Rac1 and significantly inhibited insulin secretion stimulated by glucose and forskolin. Colforsin 176-185 Rac family small GTPase 1 Rattus norvegicus 50-54 14736704-11 2004 These data suggest, for the first time, that Rac1 may be involved in glucose- and forskolin-stimulated insulin secretion, possibly at the level of recruitment of secretory granules through actin cytoskeletal network reorganization. Colforsin 82-91 Rac family small GTPase 1 Rattus norvegicus 45-49 14749354-0 2004 Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells. Colforsin 144-153 carbonyl reductase 1 Homo sapiens 70-107 14749354-2 2004 15-PGDH could be induced by IL-6 and forskolin in addition to androgens in a time- and dose-dependent manner but not by other cytokines and growth factors in LNCaP cells. Colforsin 37-46 carbonyl reductase 1 Homo sapiens 0-7 14749358-10 2004 In granulosa cell culture, SNURF mRNA accumulation was transiently increased by treatment with the LH agonists phorbol myristate and forskolin at 4 h after treatment and at 48 h in differentiated cells expressing markers of the preovulatory phenotype. Colforsin 133-142 SNRPN upstream reading frame Mus musculus 27-32 14749354-3 2004 Concurrent addition of IL-6 and forskolin showed additive effect in the induction of 15-PGDH activity. Colforsin 32-41 carbonyl reductase 1 Homo sapiens 85-92 14749354-4 2004 However, combined addition of dihydrotestosterone (DHT) and IL-6 or DHT plus forskolin exhibited synergistic induction of 15-PGDH activity. Colforsin 77-86 carbonyl reductase 1 Homo sapiens 122-129 14749354-7 2004 The induction by forskolin plus DHT or by either agent or by IL-6 alone was greatly inhibited by H-89, indicating the involvement of protein kinase A in the actions of forskolin, DHT, and IL-6. Colforsin 17-26 interleukin 6 Homo sapiens 188-192 14749354-7 2004 The induction by forskolin plus DHT or by either agent or by IL-6 alone was greatly inhibited by H-89, indicating the involvement of protein kinase A in the actions of forskolin, DHT, and IL-6. Colforsin 168-177 interleukin 6 Homo sapiens 61-65 14749354-9 2004 These results indicate that the induction of 15-PGDH by DHT, IL-6, and forskolin in LNCaP cells may involve a functional androgen receptor and phosphorylation-dependent multiple signaling pathways. Colforsin 71-80 carbonyl reductase 1 Homo sapiens 45-52 14702333-0 2004 Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent. Colforsin 0-9 carbonic anhydrase 1 Homo sapiens 29-32 15140465-8 2004 We also confirmed (using forskolin (20 microM) and phorbol 12-myristate 13-acetate (TPA) (100 nM)) that adenylate cyclase and protein kinase C participate in the downstream signaling responsible for the stimulation of BDNF synthesis, whereas in the regulation of NGF synthesis only the participation of protein kinase C was confirmed. Colforsin 25-34 brain-derived neurotrophic factor Rattus norvegicus 218-222 15140465-8 2004 We also confirmed (using forskolin (20 microM) and phorbol 12-myristate 13-acetate (TPA) (100 nM)) that adenylate cyclase and protein kinase C participate in the downstream signaling responsible for the stimulation of BDNF synthesis, whereas in the regulation of NGF synthesis only the participation of protein kinase C was confirmed. Colforsin 25-34 nerve growth factor Rattus norvegicus 263-266 15209361-5 2004 In this study, DBcAMP or forskolin reduced SNP-induced JNK/SAPK activation to the basal level, but KT5720 reversed the inhibitory effects of these two agents. Colforsin 25-34 mitogen-activated protein kinase 8 Rattus norvegicus 55-58 15209361-5 2004 In this study, DBcAMP or forskolin reduced SNP-induced JNK/SAPK activation to the basal level, but KT5720 reversed the inhibitory effects of these two agents. Colforsin 25-34 mitogen-activated protein kinase 9 Rattus norvegicus 59-63 15209361-6 2004 In contrast to JNK/SAPK activation, DBcAMP and forskolin significantly enhanced SNP-activated p38 MAPK phosphorylation and did not affect SNP-mediated ERK activation. Colforsin 47-56 mitogen activated protein kinase 14 Rattus norvegicus 94-97 15209361-7 2004 KT5720 reversed the effects of DBcAMP and forskolin on p38 MAPK phosphorylation. Colforsin 42-51 mitogen activated protein kinase 14 Rattus norvegicus 55-58 15128284-4 2004 Both mRNA and protein expression of CYP21 was upregulated with forskolin and A-II alone and in combination, as detected by Northern and Western blotting. Colforsin 63-72 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 36-41 15128284-5 2004 Whereas expression of CYP17 mRNA and protein was up regulated in the presence of forskolin and forskolin in combination with insulin. Colforsin 81-90 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-27 15128284-5 2004 Whereas expression of CYP17 mRNA and protein was up regulated in the presence of forskolin and forskolin in combination with insulin. Colforsin 95-104 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-27 15128284-7 2004 Forskolin, A-II and insulin increased the protein expression of SF-1. Colforsin 0-9 splicing factor 1 Homo sapiens 64-68 15128284-8 2004 Increased binding of SF-1 to its response element in the presence of forskolin, A-II and insulin was observed. Colforsin 69-78 splicing factor 1 Homo sapiens 21-25 15128284-8 2004 Increased binding of SF-1 to its response element in the presence of forskolin, A-II and insulin was observed. Colforsin 69-78 NLR family pyrin domain containing 3 Homo sapiens 80-96 15128284-10 2004 Increased protein expression of nur77 and the greatest binding of nur77 to its response element was seen when cells were stimulated with A-II in combination with forskolin. Colforsin 162-171 nuclear receptor subfamily 4 group A member 1 Homo sapiens 32-37 15128284-10 2004 Increased protein expression of nur77 and the greatest binding of nur77 to its response element was seen when cells were stimulated with A-II in combination with forskolin. Colforsin 162-171 nuclear receptor subfamily 4 group A member 1 Homo sapiens 66-71 14742439-6 2004 Activation of the cAMP pathway by dibutyryl cAMP (0.5 mm) alone or in combination with forskolin (20 microm) caused a 2-5-fold increase in the SMN promoter activity but had no effect on the CRE-II mutated promoter. Colforsin 87-96 survival of motor neuron 1, telomeric Homo sapiens 143-146 15082775-9 2004 Several of the CREB targets were altered in their expression by treatment with forskolin; interestingly, both induced and repressed genes were found. Colforsin 79-88 cAMP responsive element binding protein 1 Homo sapiens 15-19 15149737-3 2004 Expression levels of the natriuretic peptide receptor B (NPR-B), but not the natriruetic peptide receptor A (NPR-A) were also increased by forskolin, rising to a level of approximately 2 times control at 96 h. NPR-B transcript levels in the presence of dibutyryl cAMP were unaltered by the protein kinase A (PKA) inhibitor KT-5720, suggesting a PKA-independent pathway to NPR-B up-regulation. Colforsin 139-148 natriuretic peptide receptor 2 Homo sapiens 25-55 15149737-3 2004 Expression levels of the natriuretic peptide receptor B (NPR-B), but not the natriruetic peptide receptor A (NPR-A) were also increased by forskolin, rising to a level of approximately 2 times control at 96 h. NPR-B transcript levels in the presence of dibutyryl cAMP were unaltered by the protein kinase A (PKA) inhibitor KT-5720, suggesting a PKA-independent pathway to NPR-B up-regulation. Colforsin 139-148 natriuretic peptide receptor 2 Homo sapiens 57-62 15149737-3 2004 Expression levels of the natriuretic peptide receptor B (NPR-B), but not the natriruetic peptide receptor A (NPR-A) were also increased by forskolin, rising to a level of approximately 2 times control at 96 h. NPR-B transcript levels in the presence of dibutyryl cAMP were unaltered by the protein kinase A (PKA) inhibitor KT-5720, suggesting a PKA-independent pathway to NPR-B up-regulation. Colforsin 139-148 natriuretic peptide receptor 2 Homo sapiens 210-215 15149737-3 2004 Expression levels of the natriuretic peptide receptor B (NPR-B), but not the natriruetic peptide receptor A (NPR-A) were also increased by forskolin, rising to a level of approximately 2 times control at 96 h. NPR-B transcript levels in the presence of dibutyryl cAMP were unaltered by the protein kinase A (PKA) inhibitor KT-5720, suggesting a PKA-independent pathway to NPR-B up-regulation. Colforsin 139-148 natriuretic peptide receptor 2 Homo sapiens 210-215 15149737-6 2004 The dibutyryl cAMP/forskolin effect on NPR-C transcript was not reproduced by the beta2-selective adrenergic agonist isoproterenol (10 microM), but was replicated by incubation with the phosphodiesterase inhibitor isobutylmethylxanthine (0.5 mM). Colforsin 19-28 natriuretic peptide receptor 3 Homo sapiens 39-44 15050422-6 2004 Stimulating cells with dibutyryl-cAMP, cholera toxin and forskolin for 24 h increased (125)I-[Tyr(8)]-bradykinin (90 pM) binding with approximately 50%. Colforsin 57-66 kininogen 1 Homo sapiens 102-112 14761970-3 2004 Differential display analysis of rat primary Sertoli cell mRNA identified Id2 as being inducible by forskolin, a stimulator of cAMP production. Colforsin 100-109 inhibitor of DNA binding 2 Rattus norvegicus 74-77 14761970-4 2004 Northern blot analysis confirmed that Id2 mRNA expression peaked in Sertoli cells 6-12 h after stimulation with forskolin or follicle-stimulating hormone (FSH), the major physiological stimulator of cAMP in Sertoli cells. Colforsin 112-121 inhibitor of DNA binding 2 Rattus norvegicus 38-41 14761970-5 2004 Similarly, Id2 promoter activity in Sertoli cells was induced after forskolin or FSH stimulation as well as by overexpression of protein kinase A. Colforsin 68-77 inhibitor of DNA binding 2 Rattus norvegicus 11-14 14761970-6 2004 Forskolin induction of the Id2 promoter required sequences located between positions -122 and -82. Colforsin 0-9 inhibitor of DNA binding 2 Rattus norvegicus 27-30 15062850-8 2004 Both Bt(2)cAMP, a permeable analogue of cAMP, and forskolin, which directly activates adenylate cyclase, also induced an increase in Tyr phosphorylation of p38 MAP kinase. Colforsin 50-59 mitogen-activated protein kinase 14 Mus musculus 156-159 15149737-1 2004 Activation of the intracellular cAMP-signaling pathway by either forskolin or the cAMP-mimetic dibutyryl cAMP significantly increased transcript levels of NPR-C in primary cultures of human aortic smooth muscle cells. Colforsin 65-74 natriuretic peptide receptor 3 Homo sapiens 155-160 21214998-4 2004 RESULTS: (1) Before forskolin treatment, the activity of PKA of L9981-nm23-H1-pLXSN was remarkably higher than those of L9981 and L9981-pLXSN (P < 0.01), but no significant difference in the PKA activity was observed between L9981 and L9981-pLXSN (P > 0.05). Colforsin 20-29 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 70-77 21214998-7 2004 CONCLUSIONS: (1)Transfection of nm23-H1 gene can up-regulate the PKA activity of human high-metastasis large cell lung cancer cell line L9981, and its function as a tumor metastasis suppressor gene may be related to its effects on regulation of PKA signal transduction pathways; (2)Forskolin can remarkably up-regulate the PKA activity of L9981 cell line, and the elevation of PKA activity has a time-dependent and dose-dependent relation to forskolin. Colforsin 282-291 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 32-39 21214998-7 2004 CONCLUSIONS: (1)Transfection of nm23-H1 gene can up-regulate the PKA activity of human high-metastasis large cell lung cancer cell line L9981, and its function as a tumor metastasis suppressor gene may be related to its effects on regulation of PKA signal transduction pathways; (2)Forskolin can remarkably up-regulate the PKA activity of L9981 cell line, and the elevation of PKA activity has a time-dependent and dose-dependent relation to forskolin. Colforsin 442-451 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 32-39 14742439-10 2004 Combined treatment with dibutyryl cAMP and forskolin significantly increased the level of both the full-length and exon 7-deleted SMN (exonDelta7SMN) transcript in primary hepatocytes from mice expressing two copies of human SMN2 gene. Colforsin 43-52 survival motor neuron 1 Mus musculus 130-133 15033439-2 2004 Inhibition of forskolin-stimulated cAMP accumulation induced by alpha(2)-adrenergic receptor activation is altered following exposure of the neuron SH-SY5Y cell line to tumor necrosis factor-alpha (TNF). Colforsin 14-23 tumor necrosis factor Homo sapiens 169-196 15033439-2 2004 Inhibition of forskolin-stimulated cAMP accumulation induced by alpha(2)-adrenergic receptor activation is altered following exposure of the neuron SH-SY5Y cell line to tumor necrosis factor-alpha (TNF). Colforsin 14-23 tumor necrosis factor Homo sapiens 198-201 14742439-10 2004 Combined treatment with dibutyryl cAMP and forskolin significantly increased the level of both the full-length and exon 7-deleted SMN (exonDelta7SMN) transcript in primary hepatocytes from mice expressing two copies of human SMN2 gene. Colforsin 43-52 survival of motor neuron 2, centromeric Homo sapiens 225-229 15063152-8 2004 Our data demonstrated that (1) S-petasin inhibits ACTH- or forskolin-stimulated cellular cAMP production, (2) S-petasin increased the Michaelis constants of P450scc and 11beta-hydroxylase and (3) S-petasin decreased the expression levels and mRNA of steroidogenic acute regulatory protein. Colforsin 59-68 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 157-164 15020218-5 2004 Dexras1 decreased forskolin-stimulated CREB activation (P < 0.01) and this activity was also inhibited by co-expression of RGS4. Colforsin 18-27 ras related dexamethasone induced 1 Homo sapiens 0-7 15020218-5 2004 Dexras1 decreased forskolin-stimulated CREB activation (P < 0.01) and this activity was also inhibited by co-expression of RGS4. Colforsin 18-27 cAMP responsive element binding protein 1 Homo sapiens 39-43 15020218-5 2004 Dexras1 decreased forskolin-stimulated CREB activation (P < 0.01) and this activity was also inhibited by co-expression of RGS4. Colforsin 18-27 regulator of G protein signaling 4 Homo sapiens 126-130 15003937-4 2004 A wide variety of neurohumoral agents and inflammatory stimuli was without effect on lactoferrin and lysozyme release from HTE or Calu-3 cells, although forskolin did stimulate secretion of water and lysozyme from Calu-3 cells. Colforsin 153-162 lysozyme Homo sapiens 200-208 15003937-5 2004 However, the concentration of lysozyme in the forskolin-induced secretions was much less than in airway gland secretions. Colforsin 46-55 lysozyme Homo sapiens 30-38 15180304-7 2004 Both phorbol 12-myristate 13-acetate (PMA; 2.5 mM) and forskolin (FSK; 5 mM) increased the c-fos and c-jun mRNA expressions. Colforsin 55-64 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 91-96 15180304-7 2004 Both phorbol 12-myristate 13-acetate (PMA; 2.5 mM) and forskolin (FSK; 5 mM) increased the c-fos and c-jun mRNA expressions. Colforsin 55-64 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 101-106 15180304-7 2004 Both phorbol 12-myristate 13-acetate (PMA; 2.5 mM) and forskolin (FSK; 5 mM) increased the c-fos and c-jun mRNA expressions. Colforsin 66-69 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 91-96 15180304-7 2004 Both phorbol 12-myristate 13-acetate (PMA; 2.5 mM) and forskolin (FSK; 5 mM) increased the c-fos and c-jun mRNA expressions. Colforsin 66-69 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 101-106 15180304-9 2004 When LPS was co-treated with either PMA or FSK, it showed an additive interaction for the induction of c-jun mRNA expression. Colforsin 43-46 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 103-108 15053922-10 2004 Elevated levels of cAMP induced by forskolin mimicked the effects of relaxation on the regulation of Cyr61, CTGF and Nov. Colforsin 35-44 cellular communication network factor 1 Homo sapiens 101-106 15053922-10 2004 Elevated levels of cAMP induced by forskolin mimicked the effects of relaxation on the regulation of Cyr61, CTGF and Nov. Colforsin 35-44 cellular communication network factor 2 Homo sapiens 108-112 15053922-10 2004 Elevated levels of cAMP induced by forskolin mimicked the effects of relaxation on the regulation of Cyr61, CTGF and Nov. Colforsin 35-44 cellular communication network factor 3 Homo sapiens 117-120 15047617-4 2004 Only in cells overexpressing the wild-type liver PFK-2/FBPase-2 isoform was the increase of GK activity abolished by forskolin, apparently due to the regulatory site for phosphorylation by a cAMP-dependent protein kinase. Colforsin 117-126 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Rattus norvegicus 49-54 14615375-6 2004 The EPAC-specific cAMP analog 8CPT-2Me-cAMP (8-(4-chloro-phenylthio)-2"-O-methyladenosine-3",5"-cAMP) activates Rap1 in B-CLL cells, but, unlike rolipram/forskolin or 8-Bromo-cAMP, it does not induce PKA activation, as judged by phosphorylation of the transcription factor cAMP-response element binding protein (CREB). Colforsin 154-163 Rap guanine nucleotide exchange factor 3 Homo sapiens 4-8 14615375-6 2004 The EPAC-specific cAMP analog 8CPT-2Me-cAMP (8-(4-chloro-phenylthio)-2"-O-methyladenosine-3",5"-cAMP) activates Rap1 in B-CLL cells, but, unlike rolipram/forskolin or 8-Bromo-cAMP, it does not induce PKA activation, as judged by phosphorylation of the transcription factor cAMP-response element binding protein (CREB). Colforsin 154-163 RAB guanine nucleotide exchange factor 1 Homo sapiens 112-116 14691013-3 2004 We have shown that exposing granulosa cells to 5alpha-dihydrotestosterone (DHT) reduces forskolin-stimulated cyclin D2 mRNA expression, which leads to cell cycle arrest resulting in reduced cell proliferation. Colforsin 88-97 cyclin D2 Rattus norvegicus 109-118 14691013-7 2004 DHT treatment reduced forskolin stimulation of ERK phosphorylation. Colforsin 22-31 mitogen activated protein kinase 1 Rattus norvegicus 47-50 14963006-9 2004 Forskolin activated caspase-3 and attenuated basal ERK phosphorylation, which were prevented by SQ22536, endothelin-1, or bFGF. Colforsin 0-9 caspase 3 Rattus norvegicus 20-29 14963006-9 2004 Forskolin activated caspase-3 and attenuated basal ERK phosphorylation, which were prevented by SQ22536, endothelin-1, or bFGF. Colforsin 0-9 Eph receptor B1 Rattus norvegicus 51-54 14963006-9 2004 Forskolin activated caspase-3 and attenuated basal ERK phosphorylation, which were prevented by SQ22536, endothelin-1, or bFGF. Colforsin 0-9 endothelin 1 Rattus norvegicus 105-117 14963006-9 2004 Forskolin activated caspase-3 and attenuated basal ERK phosphorylation, which were prevented by SQ22536, endothelin-1, or bFGF. Colforsin 0-9 fibroblast growth factor 2 Rattus norvegicus 122-126 14715707-5 2004 During syncytialization these elements interacted with increasing amounts of the transcription factors Sp1, Sp3, and AP-2alpha in electrophoretic mobility shift assay, but only AP-2alpha binding rose upon elevation of cAMP levels with forskolin. Colforsin 235-244 Sp3 transcription factor Homo sapiens 108-111 14715707-5 2004 During syncytialization these elements interacted with increasing amounts of the transcription factors Sp1, Sp3, and AP-2alpha in electrophoretic mobility shift assay, but only AP-2alpha binding rose upon elevation of cAMP levels with forskolin. Colforsin 235-244 adaptor related protein complex 2 subunit alpha 1 Homo sapiens 117-126 15047617-4 2004 Only in cells overexpressing the wild-type liver PFK-2/FBPase-2 isoform was the increase of GK activity abolished by forskolin, apparently due to the regulatory site for phosphorylation by a cAMP-dependent protein kinase. Colforsin 117-126 fructose-bisphosphatase 2 Rattus norvegicus 55-63 15047617-4 2004 Only in cells overexpressing the wild-type liver PFK-2/FBPase-2 isoform was the increase of GK activity abolished by forskolin, apparently due to the regulatory site for phosphorylation by a cAMP-dependent protein kinase. Colforsin 117-126 glucokinase Rattus norvegicus 92-94 14760501-3 2004 Eel ANP, eel CNP and the NPR-C-specific C-ANF inhibited the forskolin-stimulated production of cyclic AMP. Colforsin 60-69 2',3'-cyclic nucleotide 3' phosphodiesterase Equus caballus 13-16 14760501-3 2004 Eel ANP, eel CNP and the NPR-C-specific C-ANF inhibited the forskolin-stimulated production of cyclic AMP. Colforsin 60-69 natriuretic peptide receptor 3 Rattus norvegicus 25-30 15030385-3 2004 Here, we report that KCl and forskolin synergistically increase CCK gene transcription via protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) signalling pathways, activating cAMP response element-binding protein (CREB) associated with the CRE(- 80) element of the CCK promoter. Colforsin 29-38 cholecystokinin Homo sapiens 284-287 15030385-6 2004 Moreover GAL4-CREB-DIEDML, which mediates the phosphorylation-independent binding of CBP, and the C-terminal domain of CBP was synergistically activated by forskolin and KCl. Colforsin 156-165 galectin 4 Homo sapiens 9-13 15030385-0 2004 KCl and forskolin synergistically up-regulate cholecystokinin gene expression via coordinate activation of CREB and the co-activator CBP. Colforsin 8-17 cholecystokinin Homo sapiens 46-61 15030385-6 2004 Moreover GAL4-CREB-DIEDML, which mediates the phosphorylation-independent binding of CBP, and the C-terminal domain of CBP was synergistically activated by forskolin and KCl. Colforsin 156-165 cAMP responsive element binding protein 1 Homo sapiens 14-18 15030385-0 2004 KCl and forskolin synergistically up-regulate cholecystokinin gene expression via coordinate activation of CREB and the co-activator CBP. Colforsin 8-17 cAMP responsive element binding protein 1 Homo sapiens 107-111 15030385-6 2004 Moreover GAL4-CREB-DIEDML, which mediates the phosphorylation-independent binding of CBP, and the C-terminal domain of CBP was synergistically activated by forskolin and KCl. Colforsin 156-165 CREB binding protein Homo sapiens 85-88 15030385-0 2004 KCl and forskolin synergistically up-regulate cholecystokinin gene expression via coordinate activation of CREB and the co-activator CBP. Colforsin 8-17 CREB binding protein Homo sapiens 133-136 15030385-3 2004 Here, we report that KCl and forskolin synergistically increase CCK gene transcription via protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) signalling pathways, activating cAMP response element-binding protein (CREB) associated with the CRE(- 80) element of the CCK promoter. Colforsin 29-38 cholecystokinin Homo sapiens 64-67 15030385-6 2004 Moreover GAL4-CREB-DIEDML, which mediates the phosphorylation-independent binding of CBP, and the C-terminal domain of CBP was synergistically activated by forskolin and KCl. Colforsin 156-165 CREB binding protein Homo sapiens 119-122 15030385-3 2004 Here, we report that KCl and forskolin synergistically increase CCK gene transcription via protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) signalling pathways, activating cAMP response element-binding protein (CREB) associated with the CRE(- 80) element of the CCK promoter. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 118-155 15072550-9 2004 The receptor-independent cAMP activator forskolin elevated sst1 and sst2 mRNA levels but did not affect sst5 expression, suggesting the stimulatory actions of high- and low-dose SRIF on sst1 and high-dose SRIF on sst2 mRNA levels can be mediated by activation of cAMP, whereas the stimulatory effect of high-dose SRIF on sst5 mRNA is elicited by a cAMP-independent pathway. Colforsin 40-49 somatostatin receptor 5 Sus scrofa 321-325 15030385-3 2004 Here, we report that KCl and forskolin synergistically increase CCK gene transcription via protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) signalling pathways, activating cAMP response element-binding protein (CREB) associated with the CRE(- 80) element of the CCK promoter. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 157-160 15030385-3 2004 Here, we report that KCl and forskolin synergistically increase CCK gene transcription via protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) signalling pathways, activating cAMP response element-binding protein (CREB) associated with the CRE(- 80) element of the CCK promoter. Colforsin 29-38 cAMP responsive element binding protein 1 Homo sapiens 194-231 15030385-3 2004 Here, we report that KCl and forskolin synergistically increase CCK gene transcription via protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) signalling pathways, activating cAMP response element-binding protein (CREB) associated with the CRE(- 80) element of the CCK promoter. Colforsin 29-38 cAMP responsive element binding protein 1 Homo sapiens 233-237 15056290-3 2004 RT-PCR analysis revealed that dopamine, D1 agonist, forskolin and 8-Br-cAMP stimulation potentiated PDE7B transcription in striatal neurons, while D2 agonist failed to activate the PDE7B transcription. Colforsin 52-61 phosphodiesterase 7B Rattus norvegicus 100-105 15072550-9 2004 The receptor-independent cAMP activator forskolin elevated sst1 and sst2 mRNA levels but did not affect sst5 expression, suggesting the stimulatory actions of high- and low-dose SRIF on sst1 and high-dose SRIF on sst2 mRNA levels can be mediated by activation of cAMP, whereas the stimulatory effect of high-dose SRIF on sst5 mRNA is elicited by a cAMP-independent pathway. Colforsin 40-49 somatostatin Sus scrofa 178-182 15072550-9 2004 The receptor-independent cAMP activator forskolin elevated sst1 and sst2 mRNA levels but did not affect sst5 expression, suggesting the stimulatory actions of high- and low-dose SRIF on sst1 and high-dose SRIF on sst2 mRNA levels can be mediated by activation of cAMP, whereas the stimulatory effect of high-dose SRIF on sst5 mRNA is elicited by a cAMP-independent pathway. Colforsin 40-49 somatostatin Sus scrofa 205-209 15072550-9 2004 The receptor-independent cAMP activator forskolin elevated sst1 and sst2 mRNA levels but did not affect sst5 expression, suggesting the stimulatory actions of high- and low-dose SRIF on sst1 and high-dose SRIF on sst2 mRNA levels can be mediated by activation of cAMP, whereas the stimulatory effect of high-dose SRIF on sst5 mRNA is elicited by a cAMP-independent pathway. Colforsin 40-49 somatostatin Sus scrofa 205-209 15072550-11 2004 Since the actions of GHRH and ghrelin on sst expression markedly contrasted with that observed for SRIF and forskolin these results clearly indicate GHRH and ghrelin are regulating sst5 mRNA levels by a cAMP-independent signaling pathway. Colforsin 108-117 growth hormone releasing hormone Sus scrofa 149-153 15072550-11 2004 Since the actions of GHRH and ghrelin on sst expression markedly contrasted with that observed for SRIF and forskolin these results clearly indicate GHRH and ghrelin are regulating sst5 mRNA levels by a cAMP-independent signaling pathway. Colforsin 108-117 somatostatin receptor 5 Sus scrofa 181-185 15023055-10 2004 A structural model predicts that YC-1 may adopt two configurations in one site that is pseudosymmetric with the GTP binding site and equivalent to the forskolin site in AC. Colforsin 151-160 RNA binding motif single stranded interacting protein 1 Homo sapiens 33-37 15179140-8 2004 Furthermore, 8 Br-cAMP and forskolin induced HO-1. Colforsin 27-36 heme oxygenase 1 Rattus norvegicus 45-49 15044621-7 2004 Treatment of the cells with antisense oligonucleotide of ANP-C receptor that attenuated ANP-C receptor-mediated inhibition of adenylyl cyclase resulted in a complete attenuation of C-ANP(4-23)-induced stimulation of IP(3) formation, whereas FSK, db cAMP, and ISO-mediated decrease and oxotremorine and endothelin-1 (ET-1)-induced increase in IP(3) production was not affected by this treatment. Colforsin 241-244 natriuretic peptide receptor 3 Homo sapiens 57-62 15044621-7 2004 Treatment of the cells with antisense oligonucleotide of ANP-C receptor that attenuated ANP-C receptor-mediated inhibition of adenylyl cyclase resulted in a complete attenuation of C-ANP(4-23)-induced stimulation of IP(3) formation, whereas FSK, db cAMP, and ISO-mediated decrease and oxotremorine and endothelin-1 (ET-1)-induced increase in IP(3) production was not affected by this treatment. Colforsin 241-244 natriuretic peptide receptor 3 Homo sapiens 88-93 14992811-0 2004 Differential regulation of MAP2 and alphaCamKII expression in hippocampal neurones by forskolin and calcium ionophore treatment. Colforsin 86-95 microtubule associated protein 2 Homo sapiens 27-31 14752026-9 2004 Induction of HAS2 mRNA and HA synthesis by prostaglandins was mimicked by stable cAMP analogues and forskolin. Colforsin 100-109 hyaluronan synthase 2 Homo sapiens 13-17 14992811-4 2004 The levels of immunoreactive (ir-) MAP2 were increased 4 h after forskolin treatment, but were unaffected by A23187 treatment. Colforsin 65-74 microtubule associated protein 2 Homo sapiens 35-39 14688288-3 2004 Furthermore, exposure of RINm5F cells to cAMP-increasing agents, 3-isobutyl-1-methylxanthine (IBMX), and forskolin completely abolished palmitate-mediated caspase 3 activity and significantly inhibited Annexin V staining and cell death. Colforsin 105-114 caspase 3 Rattus norvegicus 155-164 14701824-10 2004 Naturally occurring mutations of ABCA1 associated with Tangier disease (C1477R, 2203X, and 2145X) severely reduced apoA-I-mediated cAMP production, ABCA1 phosphorylation, (125)I-apoA-I binding, and lipid efflux, without affecting forskolin-mediated cAMP elevation. Colforsin 230-239 phospholipid-transporting ATPase ABCA1 Cricetulus griseus 33-38 14701824-10 2004 Naturally occurring mutations of ABCA1 associated with Tangier disease (C1477R, 2203X, and 2145X) severely reduced apoA-I-mediated cAMP production, ABCA1 phosphorylation, (125)I-apoA-I binding, and lipid efflux, without affecting forskolin-mediated cAMP elevation. Colforsin 230-239 apolipoprotein A1 Homo sapiens 115-121 14688288-3 2004 Furthermore, exposure of RINm5F cells to cAMP-increasing agents, 3-isobutyl-1-methylxanthine (IBMX), and forskolin completely abolished palmitate-mediated caspase 3 activity and significantly inhibited Annexin V staining and cell death. Colforsin 105-114 annexin A5 Rattus norvegicus 202-211 14688288-7 2004 In attempts to identify this PKA-independent mechanism, we found that the newly developed cAMP analog 8CPT-2Me-cAMP, which selectively activates the cAMP-dependent guanine nucleotide exchange factor (cAMP-GEF) pathway, mimicked the protective effects of IBMX and forskolin, suggesting that the cAMP-GEF pathway is involved. Colforsin 263-272 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 29-32 14981261-8 2004 AEA and EtOH (10(-1)M) reduced the forskolin-stimulated accumulation of cAMP, but AM251, a specific antagonist of CB1-r, significantly blocked that inhibition. Colforsin 35-44 cannabinoid receptor 1 Homo sapiens 114-119 14981261-10 2004 AEA and EtOH reduced forskolin-stimulated LHRH release, but AM251 significantly blocked that inhibition. Colforsin 21-30 gonadotropin releasing hormone 1 Homo sapiens 42-46 14687662-9 2004 However, forskolin, acting in a PKA-independent manner, increased the insulin stimulation of MAP kinase and MEK, but fully abrogated the effect of DPI to enhance these insulin responses. Colforsin 9-18 insulin Homo sapiens 70-77 14592811-4 2004 NKCC activation caused by PKA inhibition was insensitive to MEK MAPK inhibitors and to insulin but was abolished by the PKA stimulators isoproterenol and forskolin. Colforsin 154-163 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 26-29 14592811-4 2004 NKCC activation caused by PKA inhibition was insensitive to MEK MAPK inhibitors and to insulin but was abolished by the PKA stimulators isoproterenol and forskolin. Colforsin 154-163 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 120-123 14687662-9 2004 However, forskolin, acting in a PKA-independent manner, increased the insulin stimulation of MAP kinase and MEK, but fully abrogated the effect of DPI to enhance these insulin responses. Colforsin 9-18 mitogen-activated protein kinase kinase 7 Homo sapiens 108-111 14687662-9 2004 However, forskolin, acting in a PKA-independent manner, increased the insulin stimulation of MAP kinase and MEK, but fully abrogated the effect of DPI to enhance these insulin responses. Colforsin 9-18 insulin Homo sapiens 168-175 15066155-10 2004 These results provide evidence for increased glutamate release from the presynaptic terminals as the expression mechanism for both tetanus-induced and forskolin-induced LTP at mossy-CA3 synapses, and evidence supporting a postsynaptic expression mechanism at Schaffer-CA1 synapses. Colforsin 151-160 carbonic anhydrase 3 Homo sapiens 182-185 15003309-7 2004 Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of gamma-globin mRNA and decreased transcriptional activity of the gamma-globin gene promoter. Colforsin 44-53 hemoglobin subunit gamma 1 Homo sapiens 92-104 15003309-7 2004 Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of gamma-globin mRNA and decreased transcriptional activity of the gamma-globin gene promoter. Colforsin 44-53 hemoglobin subunit gamma 1 Homo sapiens 156-168 14660559-3 2004 Results revealed that overexpression of USF1 or USF2 caused a marked and significant increase in basal and forskolin-inducible promoter activities (p<0.05), and these effects were dependent on the presence of a consensus E-box cis-element within the promoter fragment. Colforsin 107-116 upstream transcription factor 1 Bos taurus 40-44 15066155-10 2004 These results provide evidence for increased glutamate release from the presynaptic terminals as the expression mechanism for both tetanus-induced and forskolin-induced LTP at mossy-CA3 synapses, and evidence supporting a postsynaptic expression mechanism at Schaffer-CA1 synapses. Colforsin 151-160 carbonic anhydrase 1 Homo sapiens 268-271 15001630-8 2004 In the adrenal cancer cell line H295R and in primary cultures from adrenocortical cells, ACTH (1 nM) and forskolin (10 micro M) effectively increased seladin-1/DHCR24 expression, confirming that seladin-1/DHCR24 is modulated by the ACTH/cAMP-driven pathway. Colforsin 105-114 24-dehydrocholesterol reductase Homo sapiens 150-159 15001630-8 2004 In the adrenal cancer cell line H295R and in primary cultures from adrenocortical cells, ACTH (1 nM) and forskolin (10 micro M) effectively increased seladin-1/DHCR24 expression, confirming that seladin-1/DHCR24 is modulated by the ACTH/cAMP-driven pathway. Colforsin 105-114 24-dehydrocholesterol reductase Homo sapiens 160-166 15001630-8 2004 In the adrenal cancer cell line H295R and in primary cultures from adrenocortical cells, ACTH (1 nM) and forskolin (10 micro M) effectively increased seladin-1/DHCR24 expression, confirming that seladin-1/DHCR24 is modulated by the ACTH/cAMP-driven pathway. Colforsin 105-114 24-dehydrocholesterol reductase Homo sapiens 195-204 15001630-8 2004 In the adrenal cancer cell line H295R and in primary cultures from adrenocortical cells, ACTH (1 nM) and forskolin (10 micro M) effectively increased seladin-1/DHCR24 expression, confirming that seladin-1/DHCR24 is modulated by the ACTH/cAMP-driven pathway. Colforsin 105-114 24-dehydrocholesterol reductase Homo sapiens 205-211 15001630-8 2004 In the adrenal cancer cell line H295R and in primary cultures from adrenocortical cells, ACTH (1 nM) and forskolin (10 micro M) effectively increased seladin-1/DHCR24 expression, confirming that seladin-1/DHCR24 is modulated by the ACTH/cAMP-driven pathway. Colforsin 105-114 proopiomelanocortin Homo sapiens 232-236 14975669-3 2004 MGS0039 attenuated both glutamate-induced inhibition of forskolin-evoked cyclic AMP formation in CHO cells expressing mGluR2 (IC50 = 20 nM) or mGluR3 (IC50 = 24 nM) and glutamate-increased [35S]GTPgammaS binding to mGluR2 (pA2 = 8.2), which means that MGS0039 acts as an antagonist. Colforsin 56-65 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 118-124 14975669-3 2004 MGS0039 attenuated both glutamate-induced inhibition of forskolin-evoked cyclic AMP formation in CHO cells expressing mGluR2 (IC50 = 20 nM) or mGluR3 (IC50 = 24 nM) and glutamate-increased [35S]GTPgammaS binding to mGluR2 (pA2 = 8.2), which means that MGS0039 acts as an antagonist. Colforsin 56-65 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 215-221 14660559-3 2004 Results revealed that overexpression of USF1 or USF2 caused a marked and significant increase in basal and forskolin-inducible promoter activities (p<0.05), and these effects were dependent on the presence of a consensus E-box cis-element within the promoter fragment. Colforsin 107-116 upstream stimulatory factor 2 Bos taurus 48-52 14660559-6 2004 Interestingly, transfections with U2Delta1-220 blocked the forskolin-dependent induction of PGHS-2 mRNA in granulosa cells, whereas transfections with full-length USF2 increased PGHS-2 transcript levels. Colforsin 59-68 prostaglandin-endoperoxide synthase 2 Bos taurus 92-98 15036626-5 2004 Treatment with H89, a specific inhibitor of protein kinase A (PKA), revealed that an enhancement in the IL-10 and IL-1beta levels by dbcAMP or forskolin totally depends on the PKA pathway, while changes in the other cytokines and iNOS are independent or only partially dependent on the PKA pathway. Colforsin 143-152 interleukin 1 beta Mus musculus 114-122 15036626-0 2004 Differential regulation of inducible nitric oxide synthase and cytokine gene expression by forskolin and dibutyryl-cAMP in lipopolysaccharide-stimulated murine BV2 microglial cells. Colforsin 91-100 nitric oxide synthase 2, inducible Mus musculus 27-58 15036626-5 2004 Treatment with H89, a specific inhibitor of protein kinase A (PKA), revealed that an enhancement in the IL-10 and IL-1beta levels by dbcAMP or forskolin totally depends on the PKA pathway, while changes in the other cytokines and iNOS are independent or only partially dependent on the PKA pathway. Colforsin 143-152 nitric oxide synthase 2, inducible Mus musculus 230-234 15036626-1 2004 This study shows that two cAMP elevating agents, dibutyryl-cAMP (dbcAMP) and forskolin, regulate the expression of several cytokines and inducible nitric oxide synthase (iNOS) in a different manner. Colforsin 77-86 nitric oxide synthase 2, inducible Mus musculus 137-168 14749286-2 2004 Immunofluorescence analyses also reveal that iPLA(2)beta accumulates in the perinuclear region of INS-1 cells stimulated with glucose and forskolin. Colforsin 138-147 phospholipase A2 group VI Rattus norvegicus 45-56 15036626-1 2004 This study shows that two cAMP elevating agents, dibutyryl-cAMP (dbcAMP) and forskolin, regulate the expression of several cytokines and inducible nitric oxide synthase (iNOS) in a different manner. Colforsin 77-86 nitric oxide synthase 2, inducible Mus musculus 170-174 15036626-2 2004 Both dbcAMP and forskolin repressed lipopolysaccharide (LPS)-induced TNF-alpha expression and enhanced anti-inflammatory cytokine IL-10 level in the BV2 microglia. Colforsin 16-25 tumor necrosis factor Mus musculus 69-78 15036626-2 2004 Both dbcAMP and forskolin repressed lipopolysaccharide (LPS)-induced TNF-alpha expression and enhanced anti-inflammatory cytokine IL-10 level in the BV2 microglia. Colforsin 16-25 interleukin 10 Mus musculus 130-135 15036626-4 2004 DbcAMP increased the IL-1beta level without affecting either the IL-6 or iNOS expression, whereas forskolin repressed the IL-6 and iNOS expression level without affecting IL-1beta in the LPS-stimulated microglia. Colforsin 98-107 interleukin 6 Mus musculus 122-126 15036626-4 2004 DbcAMP increased the IL-1beta level without affecting either the IL-6 or iNOS expression, whereas forskolin repressed the IL-6 and iNOS expression level without affecting IL-1beta in the LPS-stimulated microglia. Colforsin 98-107 nitric oxide synthase 2, inducible Mus musculus 131-135 15036626-5 2004 Treatment with H89, a specific inhibitor of protein kinase A (PKA), revealed that an enhancement in the IL-10 and IL-1beta levels by dbcAMP or forskolin totally depends on the PKA pathway, while changes in the other cytokines and iNOS are independent or only partially dependent on the PKA pathway. Colforsin 143-152 interleukin 10 Mus musculus 104-109 15062554-3 2004 As determined by Western blot and RT-PCR analysis, the four forskolin-resistant mutants all were deficient in AC-4; the levels of other AC isoforms (AC-1, AC-3 and AC-5/6) were comparable to the levels in parent Y1 cells. Colforsin 60-69 immunoglobulin kappa variable 4-63 Mus musculus 110-114 15062554-4 2004 Transfection of one of the mutant clones with an AC-4 expression vector increased forskolin-stimulated cAMP signaling, and restored forskolin-induced changes in cell morphology and growth. Colforsin 82-91 immunoglobulin kappa variable 4-63 Mus musculus 49-53 15062554-4 2004 Transfection of one of the mutant clones with an AC-4 expression vector increased forskolin-stimulated cAMP signaling, and restored forskolin-induced changes in cell morphology and growth. Colforsin 132-141 immunoglobulin kappa variable 4-63 Mus musculus 49-53 15062554-5 2004 Taken together, these observations indicate that AC-4 deficiency is a hallmark of the forskolin-resistant phenotype of these mutants and suggest that AC-4 is an important target of forskolin action in the Y1 adrenal cell line. Colforsin 86-95 immunoglobulin kappa variable 4-63 Mus musculus 49-53 15062554-5 2004 Taken together, these observations indicate that AC-4 deficiency is a hallmark of the forskolin-resistant phenotype of these mutants and suggest that AC-4 is an important target of forskolin action in the Y1 adrenal cell line. Colforsin 181-190 immunoglobulin kappa variable 4-63 Mus musculus 49-53 15062554-5 2004 Taken together, these observations indicate that AC-4 deficiency is a hallmark of the forskolin-resistant phenotype of these mutants and suggest that AC-4 is an important target of forskolin action in the Y1 adrenal cell line. Colforsin 181-190 immunoglobulin kappa variable 4-63 Mus musculus 150-154 14561639-5 2004 Pretreatment with forskolin or 8-bromo-cAMP mimics the PDE4 inhibitor effect. Colforsin 18-27 phosphodiesterase 4A Homo sapiens 55-59 14962808-5 2004 Agents that increase intracellular cyclic AMP (forskolin, prostaglandin E(2)) increased PAPP-A mRNA and protein expression approximately 3-fold. Colforsin 47-56 pappalysin 1 Homo sapiens 88-94 14871834-9 2004 Forskolin, 8-bromo cAMP, and isobutylmethylxanthine (IBMX) all prevented CD47-mediated apoptosis, indicating the involvement of cAMP. Colforsin 0-9 CD47 molecule Homo sapiens 73-77 14561591-2 2004 Because a similar localization and regulation are observed in transfected Madin-Darby Canine Kidney (MDCK) cells, we investigated which segments of AQP2 are important for its routing to forskolin-sensitive vesicles and the apical membrane through analysis of AQP1-AQP2 chimeras. Colforsin 186-195 aquaporin 2 Canis lupus familiaris 148-152 14561591-4 2004 AQP1 with the NH2 tail of AQP2 was constitutively localized in both plasma membranes, whereas AQP1 with the NH2 and COOH tail of AQP2 was sorted to intracellular vesicles and translocated to the apical membrane with forskolin. Colforsin 216-225 aquaporin-1 Canis lupus familiaris 0-4 14561591-4 2004 AQP1 with the NH2 tail of AQP2 was constitutively localized in both plasma membranes, whereas AQP1 with the NH2 and COOH tail of AQP2 was sorted to intracellular vesicles and translocated to the apical membrane with forskolin. Colforsin 216-225 aquaporin-1 Canis lupus familiaris 94-98 14758043-0 2004 Influence of receptor number on the cAMP response to forskolin in Chinese hamster ovary cells transfected with human beta2-adrenoceptor. Colforsin 53-62 adrenoceptor beta 2 Homo sapiens 117-135 14592955-5 2004 Activin enhanced ACTH-, forskolin-, or dibutyryl-cAMP- but not angiotensin II (Ang II)-induced aldosterone production, whereas BMP-6 specifically augmented Ang II-induced aldosterone production. Colforsin 24-33 inhibin subunit beta E Homo sapiens 0-7 14576182-6 2004 Western analyses demonstrated that VPA treatment increased both basal and forskolin-stimulated P450c17 and P450scc protein levels, whereas the amount of steroidogenic acute regulatory protein was unaffected. Colforsin 74-83 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 95-102 14576182-6 2004 Western analyses demonstrated that VPA treatment increased both basal and forskolin-stimulated P450c17 and P450scc protein levels, whereas the amount of steroidogenic acute regulatory protein was unaffected. Colforsin 74-83 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 107-114 14764074-10 2004 In myotubes, the GYS1 promoter was sensitive to negative regulation by forskolin, whereas insulin did not increase GYS1 transcription. Colforsin 71-80 glycogen synthase 1 Homo sapiens 17-21 14730695-3 2004 The addition to the culture medium of the cAMP-elevating agent forskolin or of the cAMP analogue 8Br-cAMP produced a time-course extinction of StAR gene expression. Colforsin 63-72 steroidogenic acute regulatory protein Rattus norvegicus 143-147 14730697-0 2004 Heregulin and forskolin-induced cyclin D3 expression in Schwann cells: role of a CCAAT promoter element and CCAAT enhancer binding protein. Colforsin 14-23 cyclin D3 Homo sapiens 32-41 14730697-1 2004 Heregulin, a polypeptide growth factor, and forskolin, an adenylyl cyclase activator, synergistically stimulate expression of cyclin D3 and cell division in Schwann cells. Colforsin 44-53 cyclin D3 Homo sapiens 126-135 14730697-8 2004 Heregulin and forskolin increased steady-state levels of CCAAT/enhancer binding protein-beta (C/EBPbeta) in Schwann cells. Colforsin 14-23 CCAAT enhancer binding protein beta Homo sapiens 57-92 14730697-8 2004 Heregulin and forskolin increased steady-state levels of CCAAT/enhancer binding protein-beta (C/EBPbeta) in Schwann cells. Colforsin 14-23 CCAAT enhancer binding protein beta Homo sapiens 94-103 14730697-11 2004 In contrast to these results, mutation of a cAMP response element in the cyclin D3 promoter had only a modest effect on heregulin- and forskolin-stimulated reporter expression. Colforsin 135-144 cyclin D3 Homo sapiens 73-82 14766009-8 2004 Of interest, forskolin-induced stimulation of LHbeta gene promoter activity was observed to increase synergistically with introduction of the transcription factor, steroidogenic factor-1 (SF-1). Colforsin 13-22 luteinizing hormone subunit beta Rattus norvegicus 46-52 15005271-11 2004 The stimulatory effect of PGE1 on HGF production might be due to an increase in cAMP, since forskolin and 8-bromo-cAMP induced HGF production. Colforsin 92-101 hepatocyte growth factor Homo sapiens 34-37 15005271-11 2004 The stimulatory effect of PGE1 on HGF production might be due to an increase in cAMP, since forskolin and 8-bromo-cAMP induced HGF production. Colforsin 92-101 hepatocyte growth factor Homo sapiens 127-130 14766009-4 2004 Using pituitary cell lines, we now demonstrate that rat LHbeta gene promoter activity is stimulated following activation of the cAMP system by the adenylate cyclase activating agent, forskolin, or by the peptide, pituitary adenylate cyclase-activating peptide. Colforsin 183-192 luteinizing hormone subunit beta Rattus norvegicus 56-62 14720206-4 2004 We now report that levels of NMDAR1 subunit protein in primary neocortical cultures are increased 66% in response to forskolin, an activator of adenylyl cyclase. Colforsin 117-126 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 29-35 14720206-6 2004 Three cAMP regulatory elements (CREs) in the rat NMDAR1 promoter (- 228, - 67, and - 39) bind CREB in vitro and forskolin increases binding to two of the sites (- 228 and - 67). Colforsin 112-121 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 49-55 14766009-8 2004 Of interest, forskolin-induced stimulation of LHbeta gene promoter activity was observed to increase synergistically with introduction of the transcription factor, steroidogenic factor-1 (SF-1). Colforsin 13-22 splicing factor 1 Rattus norvegicus 164-192 14766009-5 2004 The forskolin response was eliminated with mutation of a previously identified 3" cis-acting element for the early growth response protein-1 (Egr-1) when evaluated in the context of region -207/+5 of the LHbeta gene. Colforsin 4-13 early growth response 1 Rattus norvegicus 109-140 14766009-5 2004 The forskolin response was eliminated with mutation of a previously identified 3" cis-acting element for the early growth response protein-1 (Egr-1) when evaluated in the context of region -207/+5 of the LHbeta gene. Colforsin 4-13 early growth response 1 Rattus norvegicus 142-147 14604995-9 2004 Moreover, non-palmitoylated mutants were no longer able to inhibit forskolin-stimulated cAMP formation, indicating that palmitoylation of the 5-HT(1A) receptor is critical for the enabling of G(i) protein coupling/effector signaling. Colforsin 67-76 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 142-159 14766009-5 2004 The forskolin response was eliminated with mutation of a previously identified 3" cis-acting element for the early growth response protein-1 (Egr-1) when evaluated in the context of region -207/+5 of the LHbeta gene. Colforsin 4-13 luteinizing hormone subunit beta Rattus norvegicus 204-210 15084344-2 2004 Treatment of lactotrophs for 28 h with the PKA inhibitor H89 or KT5720, an effective inhibitor of forskolin-induced proliferation, inhibited both insulin- and estradiol-induced proliferation. Colforsin 98-107 insulin Homo sapiens 146-153 12947031-5 2004 PACAP-27 and VIP both shifted the maximal CCK concentration from 10(-8) to 10(-9) M. This sensitizing effect was mimicked by forskolin. Colforsin 125-134 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 15106839-2 2004 Nurr1 expression was induced by forskolin, an adenylate cyclase activator, via activation of CREB in both N2A and C6 cells. Colforsin 32-41 nuclear receptor subfamily 4, group A, member 2 Mus musculus 0-5 15106839-2 2004 Nurr1 expression was induced by forskolin, an adenylate cyclase activator, via activation of CREB in both N2A and C6 cells. Colforsin 32-41 cAMP responsive element binding protein 1 Mus musculus 93-97 15106839-3 2004 The effect of forskolin on ERK, however, was cell specific. Colforsin 14-23 mitogen-activated protein kinase 1 Mus musculus 27-30 15106839-4 2004 ERK phosphorylation was stimulated by forskolin in N2A cells whereas it was inhibited in C6 cells. Colforsin 38-47 mitogen-activated protein kinase 1 Mus musculus 0-3 15106839-5 2004 Pretreatment with H89, a PKA inhibitor, blocked the forskolin-induced Nurr1 expression in both N2A and C6 cells. Colforsin 52-61 nuclear receptor subfamily 4, group A, member 2 Mus musculus 70-75 15106839-7 2004 Pretreatment with PD98059 inhibited the forskolin-induced Nurr1 expression in N2A cells, however, in C6 cells, Nurr1 expression was further increased. Colforsin 40-49 nuclear receptor subfamily 4, group A, member 2 Mus musculus 58-63 15106839-7 2004 Pretreatment with PD98059 inhibited the forskolin-induced Nurr1 expression in N2A cells, however, in C6 cells, Nurr1 expression was further increased. Colforsin 40-49 nuclear receptor subfamily 4, group A, member 2 Mus musculus 111-116 14578357-7 2004 In both cell types, forskolin enhanced the activity of Cdc42, but not that of Rac, although both GTPases were necessary for the formation of branched extensions. Colforsin 20-29 cell division cycle 42 Mus musculus 55-60 15625562-6 2004 We also demonstrated that in H295R cells TGF-beta inhibited both basal and forskolin-stimulated accumulation of CYP17 mRNA. Colforsin 75-84 transforming growth factor beta 1 Homo sapiens 41-49 15625562-6 2004 We also demonstrated that in H295R cells TGF-beta inhibited both basal and forskolin-stimulated accumulation of CYP17 mRNA. Colforsin 75-84 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 112-117 15625563-2 2004 Treatment of the cells with an adenylyl cyclase activator, forskolin, known to stimulate the PKA pathway, resulted in an increase in HSD11B2 mRNA content. Colforsin 59-68 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 133-140 12969890-3 2004 When measured in 1 or 2 mM Ca(2+) external solution, the aligned myocytes displayed a large ICa that was weakly regulated (20% increase) during stimulation of PKA by 2 microM forskolin. Colforsin 175-184 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 159-162 12947031-5 2004 PACAP-27 and VIP both shifted the maximal CCK concentration from 10(-8) to 10(-9) M. This sensitizing effect was mimicked by forskolin. Colforsin 125-134 vasoactive intestinal peptide Homo sapiens 13-16 12947031-5 2004 PACAP-27 and VIP both shifted the maximal CCK concentration from 10(-8) to 10(-9) M. This sensitizing effect was mimicked by forskolin. Colforsin 125-134 cholecystokinin Homo sapiens 42-45 14662724-11 2004 The desensitisation induced by long-term treatments with salmeterol and formoterol was specific for beta(2)-adrenoceptor-mediated inhibition of histamine release as the inhibitory effects of alternative cAMP-elevating compounds, prostaglandin E(2), a receptor-mediated activator of adenylate cyclase, and forskolin, a direct activator of adenylate cyclase, were unaffected by desensitising treatments. Colforsin 305-314 adrenoceptor beta 2 Homo sapiens 100-120 14662737-19 2004 Forskolin (30 nm) evoked a potentiation of VIP relaxations. Colforsin 0-9 vasoactive intestinal peptide Sus scrofa 43-46 14514518-5 2004 Forskolin (10 microM), a stimulator of adenylate cyclase and an activator of cAMP, opened BKCa channels in single FHR PASMC, which were blocked by the PKC activators phorbol 12-myristate 13-acetate (100 nM) and thymeleatoxin (100 nM). Colforsin 0-9 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 90-94 14514518-5 2004 Forskolin (10 microM), a stimulator of adenylate cyclase and an activator of cAMP, opened BKCa channels in single FHR PASMC, which were blocked by the PKC activators phorbol 12-myristate 13-acetate (100 nM) and thymeleatoxin (100 nM). Colforsin 0-9 protein kinase C, gamma Rattus norvegicus 151-154 14514518-6 2004 The inhibitory response by thymeleatoxin on forskolin-induced BKCa channel activity was blocked by Go-6983, which selectively blocks the alpha, beta, delta, gamma, and zeta PKC isozymes, and Go-6976, which selectively inhibits PKC-alpha, PKC-beta, and PKC-mu, but not by rottlerin, which selectively inhibits PKC-delta. Colforsin 44-53 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 62-66 14514518-6 2004 The inhibitory response by thymeleatoxin on forskolin-induced BKCa channel activity was blocked by Go-6983, which selectively blocks the alpha, beta, delta, gamma, and zeta PKC isozymes, and Go-6976, which selectively inhibits PKC-alpha, PKC-beta, and PKC-mu, but not by rottlerin, which selectively inhibits PKC-delta. Colforsin 44-53 protein kinase C, gamma Rattus norvegicus 173-176 14514518-6 2004 The inhibitory response by thymeleatoxin on forskolin-induced BKCa channel activity was blocked by Go-6983, which selectively blocks the alpha, beta, delta, gamma, and zeta PKC isozymes, and Go-6976, which selectively inhibits PKC-alpha, PKC-beta, and PKC-mu, but not by rottlerin, which selectively inhibits PKC-delta. Colforsin 44-53 protein kinase C, alpha Rattus norvegicus 227-236 14514518-6 2004 The inhibitory response by thymeleatoxin on forskolin-induced BKCa channel activity was blocked by Go-6983, which selectively blocks the alpha, beta, delta, gamma, and zeta PKC isozymes, and Go-6976, which selectively inhibits PKC-alpha, PKC-beta, and PKC-mu, but not by rottlerin, which selectively inhibits PKC-delta. Colforsin 44-53 protein kinase C, beta Rattus norvegicus 238-246 14514518-6 2004 The inhibitory response by thymeleatoxin on forskolin-induced BKCa channel activity was blocked by Go-6983, which selectively blocks the alpha, beta, delta, gamma, and zeta PKC isozymes, and Go-6976, which selectively inhibits PKC-alpha, PKC-beta, and PKC-mu, but not by rottlerin, which selectively inhibits PKC-delta. Colforsin 44-53 protein kinase C, gamma Rattus norvegicus 227-230 14514518-6 2004 The inhibitory response by thymeleatoxin on forskolin-induced BKCa channel activity was blocked by Go-6983, which selectively blocks the alpha, beta, delta, gamma, and zeta PKC isozymes, and Go-6976, which selectively inhibits PKC-alpha, PKC-beta, and PKC-mu, but not by rottlerin, which selectively inhibits PKC-delta. Colforsin 44-53 protein kinase C, gamma Rattus norvegicus 227-230 14662730-10 2004 The FPRL-1 activation in CHO-K1 cells is mediated by Galpha(i)/Galpha(o) proteins, as assessed by pertussis toxin sensitivity and inhibition of forskolin-induced cyclic AMP accumulation. Colforsin 144-153 formyl peptide receptor 2 Homo sapiens 4-10 14512432-5 2004 Insulin alone had no effect on 17alpha-hydroxylase activity or CYP17 mRNA expression but required costimulation with forskolin. Colforsin 117-126 insulin Homo sapiens 0-7 14693706-7 2004 Orlistat inhibited the potentiating effect of forskolin on GSIS, an effect proposed to be due to activation of a lipase. Colforsin 46-55 lipase G, endothelial type Rattus norvegicus 113-119 15319533-5 2004 RESULTS: Stimulation of cAMP dependent signal transduction by forskolin induced prominent IL-16 RT/PCR signals in OA-DF and OA-SF. Colforsin 62-71 interleukin 16 Homo sapiens 90-95 15319533-5 2004 RESULTS: Stimulation of cAMP dependent signal transduction by forskolin induced prominent IL-16 RT/PCR signals in OA-DF and OA-SF. Colforsin 62-71 OAP Homo sapiens 124-129 15319533-6 2004 In contrast, in RA-DF and RA-SF staurosporine significantly augmented IL-16 RT/PCR signals, but forskolin induced less IL-16 transcript amounts. Colforsin 96-105 interleukin 16 Homo sapiens 119-124 14512432-10 2004 Our data demonstrate that insulin stimulates PI3-kinase and extracellular signal-regulated kinase-1/2 activities in human theca cells, but only PI3-kinase mediates the insulin augmentation of forskolin-stimulated 17alpha-hydroxylase activity. Colforsin 192-201 insulin Homo sapiens 26-33 14512432-10 2004 Our data demonstrate that insulin stimulates PI3-kinase and extracellular signal-regulated kinase-1/2 activities in human theca cells, but only PI3-kinase mediates the insulin augmentation of forskolin-stimulated 17alpha-hydroxylase activity. Colforsin 192-201 insulin Homo sapiens 168-175 14667824-7 2004 Elevation of cAMP in response to forskolin was confirmed by determining the phosphorylation of cAMP response element-binding protein and activating transcription factor-1 (CREB, ATF-1), which form the downstream targets of protein kinase A. Colforsin 33-42 cathelicidin-7 Bos taurus 13-17 14667824-7 2004 Elevation of cAMP in response to forskolin was confirmed by determining the phosphorylation of cAMP response element-binding protein and activating transcription factor-1 (CREB, ATF-1), which form the downstream targets of protein kinase A. Colforsin 33-42 cAMP responsive element binding protein 1 Bos taurus 172-176 14667824-7 2004 Elevation of cAMP in response to forskolin was confirmed by determining the phosphorylation of cAMP response element-binding protein and activating transcription factor-1 (CREB, ATF-1), which form the downstream targets of protein kinase A. Colforsin 33-42 cathelicidin-7 Bos taurus 95-99 14701748-7 2004 In contrast, mutation of Ser(39) to Glu or induction of HDAC8 phosphorylation by forskolin, a potent activator of adenyl cyclase, decreases HDAC8"s enzymatic activity. Colforsin 81-90 histone deacetylase 8 Homo sapiens 56-61 14667824-7 2004 Elevation of cAMP in response to forskolin was confirmed by determining the phosphorylation of cAMP response element-binding protein and activating transcription factor-1 (CREB, ATF-1), which form the downstream targets of protein kinase A. Colforsin 33-42 activating transcription factor 1 Bos taurus 178-183 14667824-14 2004 Exposure to forskolin, which resulted in CREB and ATF-1 phosphorylation, caused a reversible decrease in cell volume (14.5+/-5%; n=20) under isosmotic and hyposmotic conditions. Colforsin 12-21 cAMP responsive element binding protein 1 Bos taurus 41-45 14667824-14 2004 Exposure to forskolin, which resulted in CREB and ATF-1 phosphorylation, caused a reversible decrease in cell volume (14.5+/-5%; n=20) under isosmotic and hyposmotic conditions. Colforsin 12-21 activating transcription factor 1 Bos taurus 50-55 14667824-18 2004 The lack of CFTR expression and decrease in cell volume in response to forskolin concomitant with hyposmolarity suggest that elevated cAMP activates a K(+) conductance. Colforsin 71-80 cathelicidin-7 Bos taurus 134-138 14691681-6 2004 This calcitonin-induced inhibition was mimicked by forskolin and dibutyryl-adenosine 3",5"-cyclic monophosphate (db-cAMP), which are protein kinase A (PKA) activators, but not by phorbol 12-myristate 13-acetate, a protein kinase C activator. Colforsin 51-60 calcitonin related polypeptide alpha Homo sapiens 5-15 14691682-6 2004 Forskolin, a PKA agonist, decreased MT1-MMP expression, which was similar to the action of PTH on MT1-MMP expression, in MG-63 cells. Colforsin 0-9 matrix metallopeptidase 14 Homo sapiens 36-43 14709151-0 2004 Forskolin up-regulates aromatase (CYP19) activity and gene transcripts in the human adrenocortical carcinoma cell line H295R. Colforsin 0-9 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 34-39 14709151-4 2004 Aromatase activity and the transcript of the CYP19 gene were highly up-regulated by forskolin, but not by dexamethasone. Colforsin 84-93 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 45-50 14593077-9 2004 The combined treatment of forskolin and phorbol ester (which mimic PGE2) as well as LRH-1, which maximally induced reporter gene expression (140-fold), was also completely inhibited by SHP. Colforsin 26-35 nuclear receptor subfamily 0 group B member 2 Homo sapiens 185-188 15456957-5 2004 Forskolin-induced cAMP accumulation and chromogranin A (CgA) secretion were inhibited by BIM-23120, BIM-23206, and somatostatin-14 in a dose-dependent manner. Colforsin 0-9 chromogranin A Homo sapiens 56-59 15456957-5 2004 Forskolin-induced cAMP accumulation and chromogranin A (CgA) secretion were inhibited by BIM-23120, BIM-23206, and somatostatin-14 in a dose-dependent manner. Colforsin 0-9 somatostatin Homo sapiens 115-130 14701748-7 2004 In contrast, mutation of Ser(39) to Glu or induction of HDAC8 phosphorylation by forskolin, a potent activator of adenyl cyclase, decreases HDAC8"s enzymatic activity. Colforsin 81-90 histone deacetylase 8 Homo sapiens 140-145 14988663-0 2004 A forskolin derivative, colforsin daropate hydrochloride, inhibits the decrease in cortical renal blood flow induced by noradrenaline or angiotensin II in anesthetized rats. Colforsin 2-11 angiotensinogen Rattus norvegicus 120-151 14722251-5 2004 Epinephrine, prostaglandin E1, and forskolin at maximum concentrations stimulated phosphorylation of the beta2AR PKA site (Ser262) by 4-fold, whereas PMA stimulated it by 2-fold. Colforsin 35-44 adrenoceptor beta 2 Homo sapiens 105-112 14674698-5 2003 Using H7721 cells transfected with the sense or antisense cDNA of protein kinase B (PKB) and some inhibitors of signal transduction, it was discovered that FSK up-regulated the expression of SLex via PKB, but it was independent of phosphotidylinositide-3-kinase (PI-3K). Colforsin 156-159 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 231-261 14668433-8 2003 activating CFTR with forskolin/3-isobutyl-1-methylxanthine alkalinized NL ASL but acidified CF ASL; and (iii). Colforsin 21-30 CF transmembrane conductance regulator Homo sapiens 11-15 14662747-7 2003 Disruption of endogenous Rin function inhibited the neurite outgrowth stimulated by forskolin and extracellular calcium entry through voltage-dependent calcium channel evoked by KCl. Colforsin 84-93 Ras-like without CAAX 2 Rattus norvegicus 25-28 14517212-9 2003 Forskolin blocked ERK phosphorylation with an EC50 of <3 microm, and the protein kinase A (PKA) inhibitor H-89 enhanced ERK phosphorylation. Colforsin 0-9 mitogen-activated protein kinase 1 Mus musculus 18-21 14654784-5 2003 Using either an artificial SMAD3/4-dependent reporter construct or the natural TGF-beta target, plasminogen activator inhibitor-1, we show that membrane-permeable dibutyryl cAMP, and other intracellular cAMP-elevating agents such as the phosphodiesterase inhibitor isobutyl-methylxanthine, the adenylate cyclase activator forskolin, or exogenous prostaglandin E2 (PGE2), interfere with TGF-beta-induced SMAD-specific gene transactivation. Colforsin 322-331 SMAD family member 3 Homo sapiens 27-32 14654784-5 2003 Using either an artificial SMAD3/4-dependent reporter construct or the natural TGF-beta target, plasminogen activator inhibitor-1, we show that membrane-permeable dibutyryl cAMP, and other intracellular cAMP-elevating agents such as the phosphodiesterase inhibitor isobutyl-methylxanthine, the adenylate cyclase activator forskolin, or exogenous prostaglandin E2 (PGE2), interfere with TGF-beta-induced SMAD-specific gene transactivation. Colforsin 322-331 transforming growth factor beta 1 Homo sapiens 79-87 14654784-5 2003 Using either an artificial SMAD3/4-dependent reporter construct or the natural TGF-beta target, plasminogen activator inhibitor-1, we show that membrane-permeable dibutyryl cAMP, and other intracellular cAMP-elevating agents such as the phosphodiesterase inhibitor isobutyl-methylxanthine, the adenylate cyclase activator forskolin, or exogenous prostaglandin E2 (PGE2), interfere with TGF-beta-induced SMAD-specific gene transactivation. Colforsin 322-331 serpin family E member 1 Homo sapiens 96-129 14607782-6 2003 TSH upregulates MCT1/CD147 expression as a function of time through a cAMP-dependent mechanism as forskolin reproduces the effect of TSH. Colforsin 98-107 solute carrier family 16 member 1 Rattus norvegicus 16-20 14597604-12 2003 Forskolin, prostaglandin E2 and 8-bromo-cyclic AMP markedly reduced the production of fibronectin by the nephritic glomeruli compared with controls in a dose-dependent manner. Colforsin 0-9 fibronectin 1 Rattus norvegicus 86-97 14575866-4 2003 Short-term activation of 5-HT1A receptors with full agonists, as well as the partial agonist, buspirone, markedly enhanced subsequent forskolin-stimulated cyclic AMP accumulation. Colforsin 134-143 5-hydroxytryptamine receptor 1A Homo sapiens 25-31 14644659-6 2003 In the brainstem, the response to forskolin or Mn(2+) was markedly stimulated by doses at or below the threshold for observable toxicity of CPF or for inhibition of fetal brain cholinesterase, whereas comparable effects were seen in the forebrain only at higher doses. Colforsin 34-43 butyrylcholinesterase Rattus norvegicus 177-191 15340247-6 2004 Infection with the PDE-Ad completely blocked the forskolin-induced stimulation of GnRH secretion and [Ca2+]i and decreased the majority of the release of cAMP into the culture medium. Colforsin 49-58 gonadotropin releasing hormone 1 Mus musculus 82-86 15381390-3 2004 To verify whether cAMP directly activates ecNOS through the cAMP-dependent protein kinase A (PKA), we evaluated (i) the influence of 8-Br-cAMP, adenosine and forskolin on ecNOS activity and phosphorylation at Ser(1177) and (ii) the effect of PKA inhibition on ecNOS activity. Colforsin 158-167 nitric oxide synthase 3 Homo sapiens 171-176 15381390-3 2004 To verify whether cAMP directly activates ecNOS through the cAMP-dependent protein kinase A (PKA), we evaluated (i) the influence of 8-Br-cAMP, adenosine and forskolin on ecNOS activity and phosphorylation at Ser(1177) and (ii) the effect of PKA inhibition on ecNOS activity. Colforsin 158-167 nitric oxide synthase 3 Homo sapiens 171-176 15381390-8 2004 Platelet exposure to 8-Br-cAMP and forskolin, beside the phosphorylation of the specific PKA substrate VASP, markedly increased the expression of ecNOS protein phosphorylated at Ser(1177). Colforsin 35-44 vasodilator stimulated phosphoprotein Homo sapiens 103-107 15381390-8 2004 Platelet exposure to 8-Br-cAMP and forskolin, beside the phosphorylation of the specific PKA substrate VASP, markedly increased the expression of ecNOS protein phosphorylated at Ser(1177). Colforsin 35-44 nitric oxide synthase 3 Homo sapiens 146-151 14506258-6 2003 We found that forskolin, a stimulator of adenylate cyclase, decreased desensitization of TRPV1. Colforsin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-94 14566820-3 2003 In our present work, we demonstrate that cAMP and forskolin are able to prevent the expression of these mesenchymal properties, probably due to blockade of the Ras-ERK pathway. Colforsin 50-59 mitogen-activated protein kinase 1 Mus musculus 164-167 14566820-4 2003 Our results also show that cAMP and forskolin are able to abolish the TGF-beta1-induced reorganization of the actin cytoskeleton that is characteristic of the mesenchymal phenotype and also inhibits the disruption of the E-cadherin cell to cell interactions. Colforsin 36-45 transforming growth factor, beta 1 Mus musculus 70-79 14566820-4 2003 Our results also show that cAMP and forskolin are able to abolish the TGF-beta1-induced reorganization of the actin cytoskeleton that is characteristic of the mesenchymal phenotype and also inhibits the disruption of the E-cadherin cell to cell interactions. Colforsin 36-45 cadherin 1 Mus musculus 221-231 14607258-7 2003 We also briefly review our recent experimental data on the molecular mechanism of chronic opioid agonist-mediated functional sensitization of forskolin-stimulated cAMP formation, in a recombinant Chinese hamster ovary cell line stably expressing the human delta-opioid receptor (hDOR/CHO). Colforsin 142-151 tumor protein p53 inducible nuclear protein 2 Homo sapiens 279-283 14607258-9 2003 Raf-1 in turn phosphorylates and sensitizes the native adenylyl cyclase VI isoenzyme in hDOR/CHO cells, causing a rebound increase in forskolin-stimulated cAMP formation upon agonist withdrawal. Colforsin 134-143 RAF proto-oncogene serine/threonine-protein kinase Cricetulus griseus 0-5 14607258-9 2003 Raf-1 in turn phosphorylates and sensitizes the native adenylyl cyclase VI isoenzyme in hDOR/CHO cells, causing a rebound increase in forskolin-stimulated cAMP formation upon agonist withdrawal. Colforsin 134-143 tumor protein p53 inducible nuclear protein 2 Homo sapiens 88-92 14657179-4 2003 GT1-7 cells express many known core circadian clock genes, and we demonstrate that oscillations of these components can be induced by stimuli such as serum and the adenylyl cyclase activator forskolin, similar to effects observed in fibroblasts. Colforsin 191-200 retinoic acid induced 1 Mus musculus 0-3 14657179-4 2003 GT1-7 cells express many known core circadian clock genes, and we demonstrate that oscillations of these components can be induced by stimuli such as serum and the adenylyl cyclase activator forskolin, similar to effects observed in fibroblasts. Colforsin 191-200 circadian locomotor output cycles kaput Mus musculus 46-51 12917106-2 2003 However, when expressed in vitro, VACM-1 attenuates basal and vasopressin- and forskolin-induced cAMP production. Colforsin 79-88 cullin 5 Homo sapiens 34-40 14636638-9 2003 The up-regulation of follistatin expression by hCG could be mimicked by all the drugs that increase the intracellular cAMP level including 8-Br-cAMP, db-cAMP, forskolin, and 3-isobutyl-1-methylxanthine (IBMX). Colforsin 159-168 follistatin Homo sapiens 21-32 14636638-9 2003 The up-regulation of follistatin expression by hCG could be mimicked by all the drugs that increase the intracellular cAMP level including 8-Br-cAMP, db-cAMP, forskolin, and 3-isobutyl-1-methylxanthine (IBMX). Colforsin 159-168 hypertrichosis 2 (generalised, congenital) Homo sapiens 47-50 14636638-10 2003 The hCG (15IU/ml)- and forskolin (10microM)-induced follistatin expression could be blocked by H89 (10microM), a specific protein kinase A (PKA) inhibitor. Colforsin 23-32 follistatin Homo sapiens 52-63 14645671-7 2003 CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay. Colforsin 30-39 cAMP responsive element binding protein 1 Rattus norvegicus 0-4 14645671-7 2003 CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay. Colforsin 30-39 CREB binding protein Rattus norvegicus 69-89 14645671-7 2003 CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay. Colforsin 152-161 cAMP responsive element binding protein 1 Rattus norvegicus 0-4 14645671-7 2003 CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay. Colforsin 152-161 cAMP responsive element binding protein 1 Rattus norvegicus 60-64 14645671-7 2003 CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay. Colforsin 152-161 CREB binding protein Rattus norvegicus 69-89 14645672-9 2003 YC-1 increased the PGE1- and forskolin-induced but not 3-isobutyl-1-methylxanthine-produced cAMP formation, suggesting inhibition of phosphodiesterase. Colforsin 29-38 RNA binding motif single stranded interacting protein 1 Homo sapiens 0-4 14645671-7 2003 CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay. Colforsin 152-161 CREB binding protein Rattus norvegicus 91-94 14645671-7 2003 CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay. Colforsin 152-161 opioid receptor mu 1 Homo sapiens 122-125 14645671-8 2003 The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction. Colforsin 165-174 cAMP responsive element binding protein 1 Rattus norvegicus 23-27 14645671-8 2003 The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction. Colforsin 165-174 opioid receptor mu 1 Homo sapiens 48-51 14645666-6 2003 CRE-gene transcription responses to beta2-agonists, forskolin, and cAMP-analogs were sensitive to p42/44-mitogen-activated protein (MAP) kinase pathway inhibitors. Colforsin 52-61 cyclin dependent kinase 20 Homo sapiens 98-101 14645671-8 2003 The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction. Colforsin 165-174 cAMP responsive element binding protein 1 Rattus norvegicus 133-137 14525809-7 2003 Immunoblot analyses and measurements of maximally activated ICa,L (in presence of forskolin or BayK 8644) show that the differences in current density between Npy+/+ and Npy-/- cannot be attributed to altered Ca2+ channel alpha1C subunit protein expression. Colforsin 82-91 inhibitor of carbonic anhydrase Mus musculus 60-63 14645671-8 2003 The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction. Colforsin 165-174 cAMP responsive element binding protein 1 Rattus norvegicus 133-137 14645671-8 2003 The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction. Colforsin 165-174 opioid receptor mu 1 Homo sapiens 184-187 14645681-3 2003 KCl-induced elevation of PEnk mRNA was distinct from activation of the PEnk gene by either cAMP or protein kinase C. Twenty-five micromolar forskolin- and 100 nM phorbol 12-myristate 13-acetate-induced elevations of PEnk mRNA were cycloheximide-sensitive and were not blocked by cyclosporin A or ascomycin. Colforsin 140-149 proenkephalin Homo sapiens 25-29 14614081-6 2003 However, when the hypothalamic slices were treated with forskolin, dexamethasone decreased AVP mRNA expression even in the presence of DRB and/or TTX. Colforsin 56-65 arginine vasopressin Rattus norvegicus 91-94 14614081-7 2003 Furthermore, AVP hnRNA expression induced by forskolin was attenuated by dexamethasone treatment in the presence of TTX. Colforsin 45-54 arginine vasopressin Rattus norvegicus 13-16 14614081-3 2003 AVP heteronuclear (hn) RNA, an indicator for gene transcription, was induced in the PVN with incubation of forskolin as reported previously, and AVP mRNA was increased by forskolin in the presence of the gene transcription inhibitor 5,6-dichloro-1-D-ribofuranosylbenzimidazole (DRB). Colforsin 107-116 arginine vasopressin Rattus norvegicus 0-3 14574451-6 2003 In control subjects isoproterenol 1 micro mol/l and forskolin 1 micro mol/l increased platelet nitric oxide synthase activity (to 0.27+/-0.08 and 0.27+/-0.07 pmol L-citrulline/10(8) platelets respectively; p<0.05 for each in comparison with basal) and cyclic GMP (to 1.84+/-0.41 and 1.86+/-0.48; p<0.05 for each in comparison with basal). Colforsin 52-61 5'-nucleotidase, cytosolic II Homo sapiens 262-265 14614081-3 2003 AVP heteronuclear (hn) RNA, an indicator for gene transcription, was induced in the PVN with incubation of forskolin as reported previously, and AVP mRNA was increased by forskolin in the presence of the gene transcription inhibitor 5,6-dichloro-1-D-ribofuranosylbenzimidazole (DRB). Colforsin 171-180 arginine vasopressin Rattus norvegicus 0-3 14614081-3 2003 AVP heteronuclear (hn) RNA, an indicator for gene transcription, was induced in the PVN with incubation of forskolin as reported previously, and AVP mRNA was increased by forskolin in the presence of the gene transcription inhibitor 5,6-dichloro-1-D-ribofuranosylbenzimidazole (DRB). Colforsin 171-180 arginine vasopressin Rattus norvegicus 145-148 12738687-6 2003 The inhibitory effects of PGE2 on TGF-beta1-induced alpha-SMA expression are mimicked by an EP2 selective agonist, butaprost, and by forskolin-induced direct activation of adenyl cyclase. Colforsin 133-142 transforming growth factor beta 1 Homo sapiens 34-43 12933794-7 2003 Forskolin, which augments REN mRNA stability in Calu-6 cells, increased binding of several proteins, including HuR and CP1, to the REN 3"-UTR, whereas 4-bromocrotonic acid, a specific thiolase inhibitor, decreased binding and elevated renin protein levels. Colforsin 0-9 renin Homo sapiens 26-29 12933794-7 2003 Forskolin, which augments REN mRNA stability in Calu-6 cells, increased binding of several proteins, including HuR and CP1, to the REN 3"-UTR, whereas 4-bromocrotonic acid, a specific thiolase inhibitor, decreased binding and elevated renin protein levels. Colforsin 0-9 ELAV like RNA binding protein 1 Homo sapiens 111-114 12933794-7 2003 Forskolin, which augments REN mRNA stability in Calu-6 cells, increased binding of several proteins, including HuR and CP1, to the REN 3"-UTR, whereas 4-bromocrotonic acid, a specific thiolase inhibitor, decreased binding and elevated renin protein levels. Colforsin 0-9 renin Homo sapiens 131-134 12933794-7 2003 Forskolin, which augments REN mRNA stability in Calu-6 cells, increased binding of several proteins, including HuR and CP1, to the REN 3"-UTR, whereas 4-bromocrotonic acid, a specific thiolase inhibitor, decreased binding and elevated renin protein levels. Colforsin 0-9 renin Homo sapiens 235-240 12829438-9 2003 Enteric group III mGluRs are functional because mGluR8 agonists inhibited forskolin-induced accumulation of cAMP in isolated myenteric ganglia, and CPPG reduced this effect. Colforsin 74-83 glutamate receptor, metabotropic 8 Mus musculus 48-54 12869384-6 2003 Cell culture studies in human colonic T84 monolayers examined the effect of hydrogen peroxide and pharmacological activation of AMPK on forskolin-stimulated chloride secretion. Colforsin 136-145 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 128-132 12869384-7 2003 Inflamed colons from IL-10-deficient mice exhibited hyporesponsiveness to forskolin stimulation in association with reductions in surface CFTR expression and increased AMPK activity. Colforsin 74-83 interleukin 10 Mus musculus 21-26 12869384-8 2003 Inhibition of AMPK restored tissue responsiveness to forskolin, whereas stimulation of AMPK with 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) induced tissue hyporesponsivness in wild-type mice. Colforsin 53-62 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 14574451-8 2003 Isoproterenol- and forskolin-stimulated cyclic GMP correlated inversely with plasma glucose and HbA(1c). Colforsin 19-28 5'-nucleotidase, cytosolic II Homo sapiens 47-50 14596681-0 2003 Steroidogenic factor-1 enhances basal and forskolin-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in GH3 cells. Colforsin 42-51 nuclear receptor subfamily 5 group A member 1 Homo sapiens 0-22 12959988-8 2003 The stimulation of zfPACAP38-2 expression by gonadotropin could be mimicked by cAMP analogs and forskolin but suppressed by H89 (10 mum), suggesting the involvement of the cAMP-protein kinase A signaling pathway. Colforsin 96-105 adenylate cyclase activating polypeptide 1b Danio rerio 19-30 14596681-3 2003 In this study, we demonstrate that SF-1 significantly enhances basal and forskolin-stimulated transcription of the human alphaGSU promoter in GH(3) cells. Colforsin 73-82 nuclear receptor subfamily 5 group A member 1 Homo sapiens 35-39 14596681-4 2003 Mutation of the GSE abolished the SF-1-mediated transactivation of basal alphaGSU promoter activity, and significantly attenuated the forskolin effect by 50%. Colforsin 134-143 CELIAC2 Homo sapiens 16-19 14596681-5 2003 Mutation of the Ser203 residue in SF-1 to Ala blocked basal transactivation of alphaGSU promoter activity, and halved the forskolin effect. Colforsin 122-131 nuclear receptor subfamily 5 group A member 1 Homo sapiens 34-38 14596681-6 2003 These data collectively reveal a direct role for SF-1 and the GSE in mediating basal and forskolin-stimulated transcription of the human alphaGSU promoter in GH(3) cells. Colforsin 89-98 nuclear receptor subfamily 5 group A member 1 Homo sapiens 49-53 14596681-6 2003 These data collectively reveal a direct role for SF-1 and the GSE in mediating basal and forskolin-stimulated transcription of the human alphaGSU promoter in GH(3) cells. Colforsin 89-98 CELIAC2 Homo sapiens 62-65 12939279-9 2003 The adenylate cyclase activators, forskolin and 8-bromo-cAMP, enhanced intercellular connectivity, the number of functional gap junctions, and Cx43 protein expression, whereas the PKA inhibitor, H89, inhibited the stimulatory effect of PGE2 on gap junctions. Colforsin 34-43 gap junction protein, alpha 1 Mus musculus 143-147 12907753-4 2003 In FRTL-5 cells, TSH withdrawal induced a rapid down-regulation of CHOP that could be prevented by forskolin (Fk). Colforsin 99-108 DNA-damage inducible transcript 3 Rattus norvegicus 67-71 14600463-6 2003 The NaF signaling pathways were investigated using forskolin and verapamil. Colforsin 51-60 C-X-C motif chemokine ligand 8 Homo sapiens 4-7 14573758-10 2003 During these studies, we observed that forskolin activation of adenylyl cyclase was greatly reduced in filamin-lacking cells. Colforsin 39-48 filamin C Homo sapiens 103-110 14613819-6 2003 The addition of alpha- or beta-ZOL (7.5, 15 and 30 microM) to cultures stimulated with FSH (0.01 microg) or forskolin (10 microM) reduced progesterone synthesis and the levels of p450scc and 3beta-HSD transcripts in a dose-dependent manner (P<0.05). Colforsin 108-117 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 179-200 12893847-11 2003 Although forskolin interacted with carbachol, allowing acid secretion in HDC-/- mice, similar results were not achieved with gastrin. Colforsin 9-18 histidine decarboxylase Mus musculus 73-76 12947014-6 2003 Inhibition of MAP kinase activation by forskolin prevented CTGF induction. Colforsin 39-48 cellular communication network factor 2 Homo sapiens 59-63 12960055-6 2003 Effects of GIP on cell survival and inhibition of caspase-3 were mimicked by forskolin, but pharmacological experiments excluded roles for MAPK kinase (Mek)1/2, phosphatidylinositol 3-kinase, protein kinase A, Epac, and Rap 1. Colforsin 77-86 gastric inhibitory polypeptide Rattus norvegicus 11-14 12969258-5 2003 Precipitated morphine withdrawal was associated with enhanced dopamine-, SKF 82958 (D1 receptor agonist)-, and forskolin-induced CREB phosphorylation. Colforsin 111-120 cAMP responsive element binding protein 1 Rattus norvegicus 129-133 14583135-4 2003 In addition, CNP caused a dose-dependent increase in cGMP formation and inhibition of forskolin-stimulated cAMP accumulation. Colforsin 86-95 natriuretic peptide C Homo sapiens 13-16 14583135-6 2003 Treatment with the NPR-A antagonist, anantin, produced no influence on basal cGMP/cAMP levels, the CNP-stimulated cGMP accumulation and CNP-induced inhibition of forskolin-stimulated cAMP accumulation. Colforsin 162-171 natriuretic peptide C Homo sapiens 136-139 14583135-7 2003 However, CNP-induced reduction of forskolin-stimulated cAMP accumulation was inhibited by pretreatment with pertussis toxin (PTX). Colforsin 34-43 natriuretic peptide C Homo sapiens 9-12 14530312-8 2003 Direct activation of protein kinase A (PKA) by forskolin elevated the transcription of IL-10 in Jurkat cells. Colforsin 47-56 interleukin 10 Homo sapiens 87-92 14523097-7 2003 Based on the differential effects of forskolin and dibutyryl-cAMP on Nf1-/- astrocytes, neurofibromin likely functions at the level of adenylyl cyclase activation. Colforsin 37-46 Neurofibromin 1 Drosophila melanogaster 88-101 12919952-7 2003 RyR2:FKBP12.6 interaction remained intact after caffeine or 4-CMC activation, but was dramatically disrupted by isoproterenol or forskolin, an activator of adenylate cyclase. Colforsin 129-138 ryanodine receptor 2 Homo sapiens 0-4 14672278-7 2003 E2 enhanced the forskolin-stimulated release of CORT by ZFR cells. Colforsin 16-25 cortistatin Rattus norvegicus 48-52 12972182-5 2003 Transfection studies using granulosa cells demonstrated that LRH-1 is a potent regulator of both basal and forskolin-induced transcription of the ovary-specific hCYP19 promoter. Colforsin 107-116 nuclear receptor subfamily 5, group A, member 2 Mus musculus 61-66 12972182-5 2003 Transfection studies using granulosa cells demonstrated that LRH-1 is a potent regulator of both basal and forskolin-induced transcription of the ovary-specific hCYP19 promoter. Colforsin 107-116 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 161-167 14527672-7 2003 Among the isoforms, BeWo expressed AP-2alpha and AP-2gamma, while FSK increased only AP-2alpha. Colforsin 66-69 transcription factor AP-2 alpha Homo sapiens 85-94 14500737-8 2003 The PKA antagonist N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89) abolishes cell proliferation effects of PTX and restores cyclin D1 expression as well as Akt membrane translocation and activation by PDGF, whereas dibutyryl cAMP and forskolin recapitulate the functions of PTX in mesangial cells. Colforsin 241-250 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 4-7 12842891-5 2003 Both dibutyryl cyclic AMP and forskolin treatment inhibited IFN-gamma promoter activity. Colforsin 30-39 interferon gamma Mus musculus 60-69 14527672-2 2003 Here we investigated P-LAP expression and the regulatory mechanisms in BeWo choriocarcinoma cells with forskolin (FSK)-induced differentiation. Colforsin 103-112 leucyl and cystinyl aminopeptidase Homo sapiens 21-26 14527672-2 2003 Here we investigated P-LAP expression and the regulatory mechanisms in BeWo choriocarcinoma cells with forskolin (FSK)-induced differentiation. Colforsin 114-117 leucyl and cystinyl aminopeptidase Homo sapiens 21-26 14527672-4 2003 FSK significantly increased P-LAP activity and mRNA. Colforsin 0-3 leucyl and cystinyl aminopeptidase Homo sapiens 28-33 14527672-5 2003 Deletion or mutation of activator protein-2 (AP-2) binding site in the footprint-3 (-216 to -172) of P-LAP promoter abrogated the stimulatory effects of FSK on luciferase activity of the construct -216/+49. Colforsin 153-156 transcription factor AP-2 alpha Homo sapiens 24-43 14527672-5 2003 Deletion or mutation of activator protein-2 (AP-2) binding site in the footprint-3 (-216 to -172) of P-LAP promoter abrogated the stimulatory effects of FSK on luciferase activity of the construct -216/+49. Colforsin 153-156 transcription factor AP-2 alpha Homo sapiens 45-49 14527672-5 2003 Deletion or mutation of activator protein-2 (AP-2) binding site in the footprint-3 (-216 to -172) of P-LAP promoter abrogated the stimulatory effects of FSK on luciferase activity of the construct -216/+49. Colforsin 153-156 leucyl and cystinyl aminopeptidase Homo sapiens 101-106 12919952-7 2003 RyR2:FKBP12.6 interaction remained intact after caffeine or 4-CMC activation, but was dramatically disrupted by isoproterenol or forskolin, an activator of adenylate cyclase. Colforsin 129-138 FKBP prolyl isomerase 1B Homo sapiens 5-13 12919952-8 2003 Isoproterenol and forskolin elevated cyclic-AMP to similar magnitudes in all cells and were associated with equivalent hyperphosphorylation of mutant and WT hRyR2. Colforsin 18-27 ryanodine receptor 2 Homo sapiens 157-162 12791666-3 2003 Forskolin or 3-isobutyl-1-methyl xanthine (IBMX), 2 inducers of adenylate cyclase, markedly enhanced, whereas cyclooxygenase (COX) inhibitors including aspirin, piroxicam, and NS398 markedly inhibited CXCR4 expression on HMECs. Colforsin 0-9 C-X-C motif chemokine receptor 4 Homo sapiens 201-206 12957658-7 2003 Forskolin (10 microM) augmented the SIN-1 effect when added at the peak of the SIN-1 response but not when ISC had returned to its baseline value. Colforsin 0-9 mitogen-activated protein kinase associated protein 1 Mus musculus 36-41 12957658-7 2003 Forskolin (10 microM) augmented the SIN-1 effect when added at the peak of the SIN-1 response but not when ISC had returned to its baseline value. Colforsin 0-9 mitogen-activated protein kinase associated protein 1 Mus musculus 79-84 12834812-4 2003 eEF2 promotes translation in its unphosphorylated form, and we observed a rapid phosphorylation of the eEF2-protein upon forskolin treatment. Colforsin 121-130 eukaryotic translation elongation factor 2 Homo sapiens 0-4 12837761-8 2003 Whole-cell patch clamping of osmolyte-treated cells showed that Delta F508 CFTR had trafficked to the plasma membrane and was activated by forskolin. Colforsin 139-148 CF transmembrane conductance regulator Homo sapiens 75-79 12748066-7 2003 Nicotine stimulation reduced forskolin-stimulated AC activity by 35%, and this inhibition was negated by either treatment with alpha-bungarotoxin, a specific antagonist of nAChR alpha 7, or cholesterol depletion from plasma membranes. Colforsin 29-38 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 172-177 12834812-4 2003 eEF2 promotes translation in its unphosphorylated form, and we observed a rapid phosphorylation of the eEF2-protein upon forskolin treatment. Colforsin 121-130 eukaryotic translation elongation factor 2 Homo sapiens 103-107 12834812-5 2003 When using specific inhibitors of the eEF2-kinase prior to forskolin treatment, we were able to inhibit the increased phosphorylation of eEF2. Colforsin 59-68 eukaryotic elongation factor 2 kinase Homo sapiens 38-49 12834812-5 2003 When using specific inhibitors of the eEF2-kinase prior to forskolin treatment, we were able to inhibit the increased phosphorylation of eEF2. Colforsin 59-68 eukaryotic translation elongation factor 2 Homo sapiens 38-42 12834812-6 2003 Furthermore, inhibition of eEF2-kinase prevented the forskolin-mediated down-regulation of cyclin D3. Colforsin 53-62 eukaryotic elongation factor 2 kinase Homo sapiens 27-38 12834812-6 2003 Furthermore, inhibition of eEF2-kinase prevented the forskolin-mediated down-regulation of cyclin D3. Colforsin 53-62 cyclin D3 Homo sapiens 91-100 12956721-5 2003 Moreover, phospho-CREB1-specific immunoreactivity is increased significantly in protein extracts of the CNS by forskolin, an activator of adenylate cyclase. Colforsin 111-120 cAMP responsive element binding protein 1 Homo sapiens 18-23 12956721-6 2003 The forskolin-induced increase in phospho-CREB1 immunoreactivity is localized to the nuclei of CNS neurons, some of which have an important role in the formation of LTM. Colforsin 4-13 cAMP responsive element binding protein 1 Homo sapiens 42-47 12970327-5 2003 HES cells express functional EP4 (with absence of expression of EP1, EP2, and EP3) receptors and stimulate cAMP release and rapid phosphorylation of ERK1/2 proteins in response to PGE(2) or forskolin. Colforsin 190-199 prostaglandin E receptor 4 Homo sapiens 29-32 12970327-5 2003 HES cells express functional EP4 (with absence of expression of EP1, EP2, and EP3) receptors and stimulate cAMP release and rapid phosphorylation of ERK1/2 proteins in response to PGE(2) or forskolin. Colforsin 190-199 mitogen-activated protein kinase 3 Homo sapiens 149-155 12950455-6 2003 Forskolin and dBcAMP also enhanced MCT2 expression, suggesting the implication of a cAMP-mediated pathway in the effect of NA. Colforsin 0-9 solute carrier family 16 (monocarboxylic acid transporters), member 7 Mus musculus 35-39 12810818-5 2003 Pretreatment of VSMCs with pertussis toxin, cholera toxin, and forskolin for 24 h also attenuated the OxLDL-stimulated Akt phosphorylation. Colforsin 63-72 AKT serine/threonine kinase 1 Homo sapiens 119-122 12966176-9 2003 The effect of VIP appears to be mediated by a cAMP/PKA-dependent mechanism as forskolin mimics, while the PKA antagonist H-89 blocks the observed enhancement of GABA currents. Colforsin 78-87 vasoactive intestinal polypeptide Mus musculus 14-17 12865141-0 2003 KCl potentiates forskolin-induced PC12 cell neurite outgrowth via protein kinase A and extracellular signal-regulated kinase signaling pathways. Colforsin 16-25 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 66-82 12783871-5 2003 Treatment with forskolin and isoproternol also caused similar increases in AQP5 expression both in vitro and in mouse lung tissue slices. Colforsin 15-24 aquaporin 5 Mus musculus 75-79 12865141-4 2003 KCl depolarization and forskolin synergistically activate the ERK signaling pathway, but whereas KCl-mediated ERK activation depends on both PKA and MEK1, forskolin activates ERK in a PKA-independent manner. Colforsin 23-32 Eph receptor B1 Rattus norvegicus 62-65 14602552-7 2003 Forskolin (adenylate cyclase activator) and sodium nitroprusside (SNP, NO donor) resulted in the VASP phosphorylation, with increase in the cAMP and cGMP level, respectively. Colforsin 0-9 vasodilator stimulated phosphoprotein Homo sapiens 97-101 14602552-7 2003 Forskolin (adenylate cyclase activator) and sodium nitroprusside (SNP, NO donor) resulted in the VASP phosphorylation, with increase in the cAMP and cGMP level, respectively. Colforsin 0-9 cathelicidin antimicrobial peptide Homo sapiens 140-144 12931189-7 2003 Endogenous Syt IV, induced by forskolin treatment, had a similar effect. Colforsin 30-39 synaptotagmin 4 Homo sapiens 11-17 12829746-4 2003 However, AVP-, dibutyryl cAMP- and forskolin-induced AQP2 translocation was strongly inhibited. Colforsin 35-44 aquaporin 2 Rattus norvegicus 53-57 12865141-4 2003 KCl depolarization and forskolin synergistically activate the ERK signaling pathway, but whereas KCl-mediated ERK activation depends on both PKA and MEK1, forskolin activates ERK in a PKA-independent manner. Colforsin 155-164 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 141-144 12865141-0 2003 KCl potentiates forskolin-induced PC12 cell neurite outgrowth via protein kinase A and extracellular signal-regulated kinase signaling pathways. Colforsin 16-25 Eph receptor B1 Rattus norvegicus 87-124 12865141-4 2003 KCl depolarization and forskolin synergistically activate the ERK signaling pathway, but whereas KCl-mediated ERK activation depends on both PKA and MEK1, forskolin activates ERK in a PKA-independent manner. Colforsin 155-164 mitogen activated protein kinase kinase 1 Rattus norvegicus 149-153 12865141-4 2003 KCl depolarization and forskolin synergistically activate the ERK signaling pathway, but whereas KCl-mediated ERK activation depends on both PKA and MEK1, forskolin activates ERK in a PKA-independent manner. Colforsin 155-164 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 184-187 12865141-3 2003 The effects of KCl and forskolin were mediated via the protein kinase A (PKA) and the extracellular signal-regulated kinase (ERK) signaling pathways, since addition of the ERK kinase (MEK1) inhibitor PD98059 and the PKA inhibitor H89 inhibits neurite outgrowth. Colforsin 23-32 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 55-71 12865141-5 2003 Finally, we find that KCl depolarization and forskolin both induce nuclear ERK2 translocation via a PKA- and MEK1-dependent pathway. Colforsin 45-54 mitogen activated protein kinase 1 Rattus norvegicus 75-79 12865141-5 2003 Finally, we find that KCl depolarization and forskolin both induce nuclear ERK2 translocation via a PKA- and MEK1-dependent pathway. Colforsin 45-54 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 100-103 12865141-3 2003 The effects of KCl and forskolin were mediated via the protein kinase A (PKA) and the extracellular signal-regulated kinase (ERK) signaling pathways, since addition of the ERK kinase (MEK1) inhibitor PD98059 and the PKA inhibitor H89 inhibits neurite outgrowth. Colforsin 23-32 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 73-76 12865141-5 2003 Finally, we find that KCl depolarization and forskolin both induce nuclear ERK2 translocation via a PKA- and MEK1-dependent pathway. Colforsin 45-54 mitogen activated protein kinase kinase 1 Rattus norvegicus 109-113 12865141-3 2003 The effects of KCl and forskolin were mediated via the protein kinase A (PKA) and the extracellular signal-regulated kinase (ERK) signaling pathways, since addition of the ERK kinase (MEK1) inhibitor PD98059 and the PKA inhibitor H89 inhibits neurite outgrowth. Colforsin 23-32 Eph receptor B1 Rattus norvegicus 86-123 12865141-6 2003 The results demonstrate that PKA and ERK play a key role in KCl- and forskolin-induced neuronal differentiation by integration of signals from both pathways. Colforsin 69-78 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 29-32 12865141-6 2003 The results demonstrate that PKA and ERK play a key role in KCl- and forskolin-induced neuronal differentiation by integration of signals from both pathways. Colforsin 69-78 Eph receptor B1 Rattus norvegicus 37-40 12865141-3 2003 The effects of KCl and forskolin were mediated via the protein kinase A (PKA) and the extracellular signal-regulated kinase (ERK) signaling pathways, since addition of the ERK kinase (MEK1) inhibitor PD98059 and the PKA inhibitor H89 inhibits neurite outgrowth. Colforsin 23-32 Eph receptor B1 Rattus norvegicus 125-128 12865141-3 2003 The effects of KCl and forskolin were mediated via the protein kinase A (PKA) and the extracellular signal-regulated kinase (ERK) signaling pathways, since addition of the ERK kinase (MEK1) inhibitor PD98059 and the PKA inhibitor H89 inhibits neurite outgrowth. Colforsin 23-32 Eph receptor B1 Rattus norvegicus 172-175 12865141-3 2003 The effects of KCl and forskolin were mediated via the protein kinase A (PKA) and the extracellular signal-regulated kinase (ERK) signaling pathways, since addition of the ERK kinase (MEK1) inhibitor PD98059 and the PKA inhibitor H89 inhibits neurite outgrowth. Colforsin 23-32 mitogen activated protein kinase kinase 1 Rattus norvegicus 184-188 12865141-3 2003 The effects of KCl and forskolin were mediated via the protein kinase A (PKA) and the extracellular signal-regulated kinase (ERK) signaling pathways, since addition of the ERK kinase (MEK1) inhibitor PD98059 and the PKA inhibitor H89 inhibits neurite outgrowth. Colforsin 23-32 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 216-219 12884304-5 2003 In the presence of dibutyryl-cAMP, forskolin, tolafentrine or 3-isobutyl-1-methylxanthine, LPS-induced G-CSF formation was enhanced in THP-1 cells, primary monocytes and whole blood. Colforsin 35-44 colony stimulating factor 3 Homo sapiens 103-108 12902981-3 2003 Here, we report that NaB specifically represses the expression of the MUC2 gene, a differentiation marker of the secretory goblet cell lineage, in forskolin- and 12-O-tetradecanoylphorbol 13-acetate-induced HT29 cells, and Cl.16E cells, a clonal derivative of HT29 cells that spontaneously differentiates into goblet cells. Colforsin 147-156 mucin 2, oligomeric mucus/gel-forming Homo sapiens 70-74 12851219-3 2003 Release of the protein appears to be regulated because forskolin decreased the amount of immunoreactive AMP-18 in primary cultures of canine antrum mucosal epithelial cells, and indomethacin gavaged into the stomach of mice reduced AMP-18 content in antrum mucosal tissue before inducing histological injury. Colforsin 55-64 gastrokine 1 Mus musculus 104-110 12851219-3 2003 Release of the protein appears to be regulated because forskolin decreased the amount of immunoreactive AMP-18 in primary cultures of canine antrum mucosal epithelial cells, and indomethacin gavaged into the stomach of mice reduced AMP-18 content in antrum mucosal tissue before inducing histological injury. Colforsin 55-64 gastrokine 1 Mus musculus 232-238 12865333-5 2003 Using HEK293 cells stably expressing MCHR1, we demonstrate that MCH, acting through MCHR1, antagonizes the action of forskolin, an adenylate cyclase activator that increases intracellular levels of cAMP. Colforsin 117-126 melanin concentrating hormone receptor 1 Homo sapiens 37-42 12865333-5 2003 Using HEK293 cells stably expressing MCHR1, we demonstrate that MCH, acting through MCHR1, antagonizes the action of forskolin, an adenylate cyclase activator that increases intracellular levels of cAMP. Colforsin 117-126 pro-melanin concentrating hormone Homo sapiens 37-40 12865333-5 2003 Using HEK293 cells stably expressing MCHR1, we demonstrate that MCH, acting through MCHR1, antagonizes the action of forskolin, an adenylate cyclase activator that increases intracellular levels of cAMP. Colforsin 117-126 melanin concentrating hormone receptor 1 Homo sapiens 84-89 12873449-9 2003 The inhibitory effect of endothelin-1 on forskolin-induced nitrite production was significantly reversed by BQ123 (1 microM: 132.4+/-5.1%; P<0.01), but not by BQ788 (1 microM: 112.7+/-4.1%; P=0.64) or unoprostone (30 microM: 109.3+/-4.8%; P=0.98). Colforsin 41-50 endothelin 1 Homo sapiens 25-37 12873449-10 2003 These results suggest that endothelin-1, through an ETA receptor activation, can reduce both basal and forskolin-induced nitrite production in isolated porcine ciliary processes. Colforsin 103-112 endothelin 1 Homo sapiens 27-39 12873449-10 2003 These results suggest that endothelin-1, through an ETA receptor activation, can reduce both basal and forskolin-induced nitrite production in isolated porcine ciliary processes. Colforsin 103-112 endothelin receptor type A Homo sapiens 52-55 12952251-8 2003 H-89, an inhibitor of PKA, was able to inhibit the decrease in eotaxin and MCP-1 protein release induced by forskolin. Colforsin 108-117 C-C motif chemokine ligand 11 Homo sapiens 63-70 12952251-5 2003 Forskolin, a direct stimulator of adenylyl cyclase, decreased the interleukin (IL)-1beta-induced eotaxin and MCP-1 release by 73+/-8 and 65+/-6%, respectively. Colforsin 0-9 interleukin 1 beta Homo sapiens 66-88 12909194-4 2003 The selective adenosine A3 receptor agonist 1-[2-chloro-6[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-beta-D-ribofuranuronamide (2-Cl-IB-MECA) inhibited forskolin-mediated [3H]cyclic AMP accumulation and stimulated concentration-dependent increases in p42/p44 mitogen-activated protein kinase (MAPK) phosphorylation. Colforsin 170-179 adenosine A3 receptor Mus musculus 14-35 12952251-5 2003 Forskolin, a direct stimulator of adenylyl cyclase, decreased the interleukin (IL)-1beta-induced eotaxin and MCP-1 release by 73+/-8 and 65+/-6%, respectively. Colforsin 0-9 C-C motif chemokine ligand 11 Homo sapiens 97-104 12952251-8 2003 H-89, an inhibitor of PKA, was able to inhibit the decrease in eotaxin and MCP-1 protein release induced by forskolin. Colforsin 108-117 C-C motif chemokine ligand 2 Homo sapiens 75-80 12952251-5 2003 Forskolin, a direct stimulator of adenylyl cyclase, decreased the interleukin (IL)-1beta-induced eotaxin and MCP-1 release by 73+/-8 and 65+/-6%, respectively. Colforsin 0-9 C-C motif chemokine ligand 2 Homo sapiens 109-114 12915658-5 2003 Incubation of SVOG cells with forskolin augmented EG-VEGF/PK-1 expression in a dose-dependent manner. Colforsin 30-39 prokineticin 1 Homo sapiens 50-57 12838503-7 2003 Stimulation with NRG-1beta in the presence of forskolin produces a dose-dependent increase in JS1 DNA synthesis. Colforsin 46-55 carboxymethylenebutenolidase homolog Homo sapiens 94-97 12915658-5 2003 Incubation of SVOG cells with forskolin augmented EG-VEGF/PK-1 expression in a dose-dependent manner. Colforsin 30-39 prokineticin 1 Homo sapiens 58-62 12887697-4 2003 Activation of PKC in DRGs from control rats was associated with a significant decrease in opioid-mediated inhibition of forskolin-stimulated cyclic AMP that was similar to the decrease in inhibition observed in DRGs from diabetic rats. Colforsin 120-129 protein kinase C, alpha Rattus norvegicus 14-17 12904172-4 2003 Although H89, a selective protein kinase A (PKA) inhibitor, completely inhibited PKA activity stimulated by rPTH(1-34), forskolin or 8-pCPTcAMP, suppression of PTH/PTHrP receptor mRNA synthesis induced by these substances in UMR-106 cells was not affected by H89. Colforsin 120-129 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 44-47 12904172-4 2003 Although H89, a selective protein kinase A (PKA) inhibitor, completely inhibited PKA activity stimulated by rPTH(1-34), forskolin or 8-pCPTcAMP, suppression of PTH/PTHrP receptor mRNA synthesis induced by these substances in UMR-106 cells was not affected by H89. Colforsin 120-129 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 81-84 12904172-8 2003 Transcriptional activation of PTH/PTHrP receptor gene promoter (U3P or U4P)-luciferase constructs was decreased by rPTH(1-34), forskolin and 8-pCPTcAMP irrespective of H89. Colforsin 127-136 parathyroid hormone Rattus norvegicus 30-33 12890570-5 2003 Since activities of CRE-luc and c-fos-luc were highly dependent on cell types, GnRH-induced CRE-luc or c-fos-luc activity was normalized by forskolin-induced CRE-luc or 12-O-tetradecanoylphenol-13-acetate (TPA)-induced c-fos-luc activity, respectively. Colforsin 140-149 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 32-37 12721330-9 2003 Indeed, the efficacy of 4P-PDOT on forskolin-stimulated cAMP formation was reversed from an MT2 partial agonist in vehicle-treated cells to that of an MT1 inverse agonist in 17beta-estradiol (0.1 microM)-treated granulosa cells. Colforsin 35-44 metallothionein 2A Rattus norvegicus 92-95 12721330-9 2003 Indeed, the efficacy of 4P-PDOT on forskolin-stimulated cAMP formation was reversed from an MT2 partial agonist in vehicle-treated cells to that of an MT1 inverse agonist in 17beta-estradiol (0.1 microM)-treated granulosa cells. Colforsin 35-44 metallothionein 1 Rattus norvegicus 151-154 12734388-3 2003 Direct activation of PKC by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) or 1,2-dioctanoyl-sn-glycerol (DOG) desensitized CRF1 receptors in Y79 cells, reducing the maximum for CRF- (but not forskolin)-stimulated cAMP accumulation by 56.3 +/- 1.2% and 40.4 +/- 2.1%, respectively (p < 0.001). Colforsin 216-225 protein kinase C alpha Homo sapiens 21-24 12890570-5 2003 Since activities of CRE-luc and c-fos-luc were highly dependent on cell types, GnRH-induced CRE-luc or c-fos-luc activity was normalized by forskolin-induced CRE-luc or 12-O-tetradecanoylphenol-13-acetate (TPA)-induced c-fos-luc activity, respectively. Colforsin 140-149 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 103-108 12890570-5 2003 Since activities of CRE-luc and c-fos-luc were highly dependent on cell types, GnRH-induced CRE-luc or c-fos-luc activity was normalized by forskolin-induced CRE-luc or 12-O-tetradecanoylphenol-13-acetate (TPA)-induced c-fos-luc activity, respectively. Colforsin 140-149 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 103-108 12730225-7 2003 It appeared in response to forskolin and was bound to both cyclin D3 and p27, presumably reflecting the activating Thr-172 phosphorylation of CDK4. Colforsin 27-36 cyclin D3 Canis lupus familiaris 59-68 12877986-5 2003 Inhibition of L-type Ca2+ channels blocks forskolin-mediated induction of proenkephalin. Colforsin 42-51 proenkephalin Homo sapiens 74-87 12730225-7 2003 It appeared in response to forskolin and was bound to both cyclin D3 and p27, presumably reflecting the activating Thr-172 phosphorylation of CDK4. Colforsin 27-36 cyclin dependent kinase inhibitor 1B Canis lupus familiaris 73-76 12730225-7 2003 It appeared in response to forskolin and was bound to both cyclin D3 and p27, presumably reflecting the activating Thr-172 phosphorylation of CDK4. Colforsin 27-36 cyclin dependent kinase 4 Canis lupus familiaris 142-146 12743114-5 2003 Treatment with forskolin, an adenylyl cyclase activator, increased that activation-associated phosphorylation of CREB, which was prolonged by tTG overexpression. Colforsin 15-24 cAMP responsive element binding protein 1 Homo sapiens 113-117 12743114-5 2003 Treatment with forskolin, an adenylyl cyclase activator, increased that activation-associated phosphorylation of CREB, which was prolonged by tTG overexpression. Colforsin 15-24 transglutaminase 2 Homo sapiens 142-145 12730225-8 2003 Upon forskolin withdrawal or after cycloheximide addition, this CDK4 phosphoform unexpectedly persisted in p27 complexes devoid of cyclin D3 but it disappeared from the more labile cyclin D3 complexes. Colforsin 5-14 cyclin dependent kinase 4 Canis lupus familiaris 64-68 12730225-8 2003 Upon forskolin withdrawal or after cycloheximide addition, this CDK4 phosphoform unexpectedly persisted in p27 complexes devoid of cyclin D3 but it disappeared from the more labile cyclin D3 complexes. Colforsin 5-14 cyclin dependent kinase inhibitor 1B Canis lupus familiaris 107-110 12730225-8 2003 Upon forskolin withdrawal or after cycloheximide addition, this CDK4 phosphoform unexpectedly persisted in p27 complexes devoid of cyclin D3 but it disappeared from the more labile cyclin D3 complexes. Colforsin 5-14 cyclin D3 Canis lupus familiaris 131-140 12831842-9 2003 In addition, AVP treatment also enhanced the expression of Gsalpha protein and Gsalpha-mediated stimulation of adenylyl cyclase by GTPgammaS, N-ethylcarboxamide adenosine (NECA), and forskolin (FSK), whereas the levels of Gbeta were not altered by AVP treatment. Colforsin 194-197 arginine vasopressin Homo sapiens 13-16 12873387-3 2003 This expression selectively decreased basal phosphorylation of a membrane-associated pool of p42/44MAPK, impaired cAMP-dependent LTP in the hippocampal Schaffer collateral pathway induced by either forskolin or theta frequency stimulation, decreased complex spike firing, and reduced the p42/44MAPK-mediated phosphorylation of the A-type potassium channel Kv4.2. Colforsin 198-207 erythrocyte membrane protein band 4.2 Mus musculus 93-96 12873387-3 2003 This expression selectively decreased basal phosphorylation of a membrane-associated pool of p42/44MAPK, impaired cAMP-dependent LTP in the hippocampal Schaffer collateral pathway induced by either forskolin or theta frequency stimulation, decreased complex spike firing, and reduced the p42/44MAPK-mediated phosphorylation of the A-type potassium channel Kv4.2. Colforsin 198-207 erythrocyte membrane protein band 4.2 Mus musculus 288-291 12873387-3 2003 This expression selectively decreased basal phosphorylation of a membrane-associated pool of p42/44MAPK, impaired cAMP-dependent LTP in the hippocampal Schaffer collateral pathway induced by either forskolin or theta frequency stimulation, decreased complex spike firing, and reduced the p42/44MAPK-mediated phosphorylation of the A-type potassium channel Kv4.2. Colforsin 198-207 potassium voltage-gated channel, Shal-related family, member 2 Mus musculus 356-361 12831842-9 2003 In addition, AVP treatment also enhanced the expression of Gsalpha protein and Gsalpha-mediated stimulation of adenylyl cyclase by GTPgammaS, N-ethylcarboxamide adenosine (NECA), and forskolin (FSK), whereas the levels of Gbeta were not altered by AVP treatment. Colforsin 183-192 arginine vasopressin Homo sapiens 13-16 12831842-9 2003 In addition, AVP treatment also enhanced the expression of Gsalpha protein and Gsalpha-mediated stimulation of adenylyl cyclase by GTPgammaS, N-ethylcarboxamide adenosine (NECA), and forskolin (FSK), whereas the levels of Gbeta were not altered by AVP treatment. Colforsin 194-197 GNAS complex locus Homo sapiens 59-66 12831842-9 2003 In addition, AVP treatment also enhanced the expression of Gsalpha protein and Gsalpha-mediated stimulation of adenylyl cyclase by GTPgammaS, N-ethylcarboxamide adenosine (NECA), and forskolin (FSK), whereas the levels of Gbeta were not altered by AVP treatment. Colforsin 183-192 GNAS complex locus Homo sapiens 59-66 12831842-9 2003 In addition, AVP treatment also enhanced the expression of Gsalpha protein and Gsalpha-mediated stimulation of adenylyl cyclase by GTPgammaS, N-ethylcarboxamide adenosine (NECA), and forskolin (FSK), whereas the levels of Gbeta were not altered by AVP treatment. Colforsin 194-197 GNAS complex locus Homo sapiens 79-86 12831842-9 2003 In addition, AVP treatment also enhanced the expression of Gsalpha protein and Gsalpha-mediated stimulation of adenylyl cyclase by GTPgammaS, N-ethylcarboxamide adenosine (NECA), and forskolin (FSK), whereas the levels of Gbeta were not altered by AVP treatment. Colforsin 183-192 GNAS complex locus Homo sapiens 79-86 14502435-5 2003 However, in the presence of 10 microM forskolin, NS004 stimulated G551D-CFTR activity in a dose-dependent manner with an EC(50) approximately 1.5 microM. Colforsin 38-47 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 72-76 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 LOW QUALITY PROTEIN: ryanodine receptor 1 Cricetulus griseus 76-80 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 LOW QUALITY PROTEIN: ryanodine receptor 1 Cricetulus griseus 104-108 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 A kinase (PRKA) anchor protein 1 Mus musculus 126-131 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 A kinase (PRKA) anchor protein 1 Mus musculus 198-203 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 LOW QUALITY PROTEIN: ryanodine receptor 1 Cricetulus griseus 104-108 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 A kinase (PRKA) anchor protein 1 Mus musculus 198-203 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 A kinase (PRKA) anchor protein 1 Mus musculus 198-203 12810087-3 2003 Here, we showed that the amount of the rat Per1 (rPer1) transcript induced by forskolin (FK) was significantly upregulated by the inhibition of phosphodiesterase type 4 (PDE4), a specific phosphodiesterase for cAMP, in rat-1 fibroblasts. Colforsin 78-87 period circadian regulator 1 Rattus norvegicus 49-54 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 LOW QUALITY PROTEIN: ryanodine receptor 1 Cricetulus griseus 104-108 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 A kinase (PRKA) anchor protein 1 Mus musculus 198-203 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 LOW QUALITY PROTEIN: ryanodine receptor 1 Cricetulus griseus 104-108 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 36-45 A kinase (PRKA) anchor protein 1 Mus musculus 198-203 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 207-216 LOW QUALITY PROTEIN: ryanodine receptor 1 Cricetulus griseus 76-80 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 207-216 A kinase (PRKA) anchor protein 1 Mus musculus 126-131 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 352-361 LOW QUALITY PROTEIN: ryanodine receptor 1 Cricetulus griseus 76-80 12709444-6 2003 Following the addition of 10 microm forskolin to activate adenylyl cyclase, RyR1 phosphorylation in CHO-RyR1 cells expressing mAKAP increased by 42.4 +/- 6.6% (n = 4) compared with cells expressing mAKAP-P. Forskolin treatment alone did not increase the amplitude of the cytosolic Ca2+ transient in CHO-RyR1 cells expressing mAKAP or mAKAP-P; however, forskolin plus 10 mm caffeine elicited a cytosolic Ca2+ transient, the amplitude of which increased by 22% (p < 0.05) in RyR1/mAKAP-expressing cells compared with RyR1/mAKAP-P-expressing cells. Colforsin 352-361 A kinase (PRKA) anchor protein 1 Mus musculus 126-131 12926078-0 2003 Reduction of MDR3 mRNA levels by forskolin in Chang liver cells. Colforsin 33-42 ATP binding cassette subfamily B member 4 Homo sapiens 13-17 12812976-8 2003 There was a greater rate of growth in mutant cells; forskolin and isoproterenol inhibited LPA-induced ERK1/2 phosphorylation in normal but not in mutant cells. Colforsin 52-61 mitogen-activated protein kinase 3 Homo sapiens 102-108 12926078-6 2003 However, forskolin decreased the induction of MDR3 mRNA expression by doxorubicin. Colforsin 9-18 ATP binding cassette subfamily B member 4 Homo sapiens 46-50 12847556-3 2003 BP 897 displays significant intrinsic activity at the human dopamine D(3) receptor by decreasing forskolin-stimulated cAMP levels and by stimulating mitogenesis of dopamine D(3)-expressing NG108-15 cells. Colforsin 97-106 dopamine receptor D3 Rattus norvegicus 60-82 12812976-11 2003 We conclude that PKA activity in CNC cells is increased and that its stimulation by forskolin or isoproterenol increases LPA-induced ERK1/2 phosphorylation, cell metabolism and proliferation. Colforsin 84-93 mitogen-activated protein kinase 3 Homo sapiens 133-139 14502440-3 2003 CFTR activity was measured using the (125I) iodide efflux technique and whole-cell patch-clamp recording in response to either forskolin or xanthine derivatives. Colforsin 127-136 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 0-4 12818573-8 2003 The MEF2-responsive promoter showed high basal expression in both myocytes and fibroblasts, and minimal induction by phorbol esters and forskolin. Colforsin 136-145 myocyte enhancer factor 2A Homo sapiens 4-8 12818573-10 2003 The CMV promoter driving TnT could be induced more than 15-fold with phenylephrine or forskolin to replace the endogenous protein almost to completion at a multiplicity of infection of 10. Colforsin 86-95 troponin T1, slow skeletal type Homo sapiens 25-28 14502440-8 2003 Furthermore, CFTR activation by forskolin or IBMX failed to promote [Ca2+]i increase, suggesting that CFTR activation did not generate an ATP release large enough to stimulate P2Y2 receptors. Colforsin 32-41 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 13-17 12815706-5 2003 When forskolin is added at 39 degrees C, however, cells display bright fibrous GFAP staining in elongated processes. Colforsin 5-14 glial fibrillary acidic protein Homo sapiens 79-83 12807435-7 2003 Forskolin or brain-derived neurotropic factor (BDNF) induced a short ania-6 mRNA, that encodes the full-length cyclin, and this induction depended on ERK. Colforsin 0-9 brain derived neurotrophic factor Homo sapiens 47-51 12890892-2 2003 Forskolin-stimulated cyclic adenosine 3,5-monophosphate (cAMP) accumulation in OX2R-expressing cells was inhibited by orexin in a dose-dependent manner, and the effect was abolished by pretreatment with pertussis toxin (PTX). Colforsin 0-9 hypocretin (orexin) receptor 2 Mus musculus 79-83 12807435-7 2003 Forskolin or brain-derived neurotropic factor (BDNF) induced a short ania-6 mRNA, that encodes the full-length cyclin, and this induction depended on ERK. Colforsin 0-9 proliferating cell nuclear antigen Homo sapiens 111-117 12807435-7 2003 Forskolin or brain-derived neurotropic factor (BDNF) induced a short ania-6 mRNA, that encodes the full-length cyclin, and this induction depended on ERK. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 150-153 12660310-3 2003 Maximal forskolin-stimulated cAMP formation in hDOR/CHO cells increased by 472 +/- 91, 399 +/- 2, and 433 +/- 73% after chronic treatment with the delta-opioid agonists (+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxy-benzyl]-N,N-diethyl benzamide (SNC 80), [d-Pen2,d-Pen5]-enkephalin, and deltorphin II, respectively. Colforsin 8-17 tumor protein p53 inducible nuclear protein 2 Homo sapiens 47-51 12810578-4 2003 Ucn III secretion from the cells was measured using a highly specific RIA, and we found that high potassium, forskolin, or high glucose can stimulate Ucn III secretion from these cells. Colforsin 109-118 urocortin 3 Mus musculus 0-7 12890892-2 2003 Forskolin-stimulated cyclic adenosine 3,5-monophosphate (cAMP) accumulation in OX2R-expressing cells was inhibited by orexin in a dose-dependent manner, and the effect was abolished by pretreatment with pertussis toxin (PTX). Colforsin 0-9 hypocretin Mus musculus 118-124 12810578-4 2003 Ucn III secretion from the cells was measured using a highly specific RIA, and we found that high potassium, forskolin, or high glucose can stimulate Ucn III secretion from these cells. Colforsin 109-118 urocortin 3 Mus musculus 150-157 12890892-3 2003 The inhibitory effect of orexin on forskolin-stimulated cAMP accumulation was not observed in OX1R-expressing cells. Colforsin 35-44 hypocretin Mus musculus 25-31 12827213-10 2003 Additional PCR experiments revealed increases in Cx43-mRNA under the influence of db-cAMP, forskolin, PDD or TNFalpha (p<0.05), which all could be completely suppressed by SB203580. Colforsin 91-100 gap junction protein alpha 1 Homo sapiens 49-53 12695506-9 2003 In rat cortical neurons we showed that head domain phosphorylation of endogenous NF-M by forskolin-activated PKA inhibits NF-M tail domain phosphorylation. Colforsin 89-98 neurofilament medium chain Rattus norvegicus 81-85 12827213-7 2003 We found significantly enhanced Cx43 content in cells treated with db-cAMP, forskolin, PDD or TNF alpha (p<0.05), while 4 alpha-PDD or the solvent DMSO exerted no effect. Colforsin 76-85 gap junction protein alpha 1 Homo sapiens 32-36 12695506-9 2003 In rat cortical neurons we showed that head domain phosphorylation of endogenous NF-M by forskolin-activated PKA inhibits NF-M tail domain phosphorylation. Colforsin 89-98 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 109-112 12695506-9 2003 In rat cortical neurons we showed that head domain phosphorylation of endogenous NF-M by forskolin-activated PKA inhibits NF-M tail domain phosphorylation. Colforsin 89-98 neurofilament medium chain Rattus norvegicus 122-126 12695506-11 2003 Epidermal growth factor stimulation of cells with mutant NF-M in the presence of forskolin exhibited no inhibition of NF-tail domain phosphorylation compared with the wild type NF-M-transfected cells. Colforsin 81-90 neurofilament medium chain Rattus norvegicus 57-61 12588708-6 2003 Pretreatment of HMEC with 10 micro M forskolin plus 1 micro M IBMX (FI) to elevate intracellular cAMP levels inhibited both thrombin-induced RhoA activation and translocation responses. Colforsin 37-46 coagulation factor II, thrombin Homo sapiens 124-132 12788080-7 2003 Forskolin (PKA activator) and PMA (PKC activator) mimicked PTH-induced NOR-1 mRNA. Colforsin 0-9 parathyroid hormone Mus musculus 59-62 12788080-7 2003 Forskolin (PKA activator) and PMA (PKC activator) mimicked PTH-induced NOR-1 mRNA. Colforsin 0-9 nuclear receptor subfamily 4, group A, member 3 Mus musculus 71-76 12609843-5 2003 In comparison, Gi-mediated signaling induced by either thrombin, ADP, or adrenaline, examined by suppression of forskolin-stimulated rise in cyclic AMP (cAMP) was impaired, indicating dysfunctional Galphai signaling. Colforsin 112-121 coagulation factor II, thrombin Homo sapiens 55-63 12588708-6 2003 Pretreatment of HMEC with 10 micro M forskolin plus 1 micro M IBMX (FI) to elevate intracellular cAMP levels inhibited both thrombin-induced RhoA activation and translocation responses. Colforsin 37-46 ras homolog family member A Homo sapiens 141-145 12646569-4 2003 Protein kinase activators (cAMP, forskolin, or phorbol-12-myristate-13-acetate) markedly increased GSTA4-4 targeting to mitochondria, whereas kinase inhibitors caused its retention in the cytosol. Colforsin 33-42 glutathione S-transferase, alpha 4 Mus musculus 99-106 12801317-5 2003 The desensitization by TGF-beta 1 was greater against ISO than for forskolin. Colforsin 67-76 transforming growth factor beta-1 proprotein Cavia porcellus 23-33 12801317-11 2003 When the tissues were incubated with TGF-beta 1 in the presence of IFN-gamma, an intracellular antagonist of TGF-beta signalling, IFN-gamma inhibited the reduced response to ISO and forskolin after exposure to TGF-beta 1 in a concentration-dependent fashion. Colforsin 182-191 transforming growth factor beta-1 proprotein Cavia porcellus 37-47 12801317-11 2003 When the tissues were incubated with TGF-beta 1 in the presence of IFN-gamma, an intracellular antagonist of TGF-beta signalling, IFN-gamma inhibited the reduced response to ISO and forskolin after exposure to TGF-beta 1 in a concentration-dependent fashion. Colforsin 182-191 transforming growth factor beta-1 proprotein Cavia porcellus 210-220 12681447-7 2003 Overexpression of PKA-DN potentiated the effects of ET1 and ATP on SRF activity, whereas stimulation of PKA by isoproterenol, forskolin or by overexpression of the PKA catalytic subunit decreased SRF activity. Colforsin 126-135 serum response factor Homo sapiens 196-199 12606603-6 2003 A-304121 and A-317920 are potent antagonists at rat H3R in reversing R-alpha-methylhistamine [(R)-alpha-MeHA] inhibition of forskolin-stimulated cAMP formation (pKb values = 8.0 and 9.1) but weak antagonists at human H3Rs in cyclase (pKb values = 6.0 and 6.3) and calcium mobilization (pKb values = 6.0 and 7.3) assays in cells co-expressing Galphaqi5-protein. Colforsin 124-133 histamine receptor H3 Rattus norvegicus 52-55 12753388-4 2003 The MAPK activation is also decreased by the adenylate cyclase stimulant forskolin. Colforsin 73-82 mitogen-activated protein kinase 1 S homeolog Xenopus laevis 4-8 12531792-4 2003 In a subset of CLL patients, B-cell lymphoma 2 (Bcl-2)-associated death promoter homolog (Bad), a proapoptotic Bcl-2 family member that when phosphorylated on specific serine residues is sequestered in the cytosol by 14-3-3, was dephosphorylated at Ser112 following rolipram/forskolin treatment of leukemic cells. Colforsin 275-284 BCL2 apoptosis regulator Homo sapiens 29-46 12757936-7 2003 There was a spontaneous, time-dependent increase of amino acid transporter B(0) mRNA in vehicle, which was suppressed by 2% oxygen and by forskolin treatment in 20% oxygen. Colforsin 138-147 solute carrier family 6 member 14 Homo sapiens 52-79 12531792-2 2003 We show that treatment of CLL cells with rolipram, a prototypic PDE4 inhibitor, and forskolin, an adenylate cyclase activator, induces mitochondrial depolarization, release of cytochrome c into the cytosol, caspase-9 and -3 activation, and cleavage of poly(adenosine diphosphate [ADP]-ribose)polymerase. Colforsin 84-93 cytochrome c, somatic Homo sapiens 176-188 12531792-2 2003 We show that treatment of CLL cells with rolipram, a prototypic PDE4 inhibitor, and forskolin, an adenylate cyclase activator, induces mitochondrial depolarization, release of cytochrome c into the cytosol, caspase-9 and -3 activation, and cleavage of poly(adenosine diphosphate [ADP]-ribose)polymerase. Colforsin 84-93 caspase 9 Homo sapiens 207-223 12531792-4 2003 In a subset of CLL patients, B-cell lymphoma 2 (Bcl-2)-associated death promoter homolog (Bad), a proapoptotic Bcl-2 family member that when phosphorylated on specific serine residues is sequestered in the cytosol by 14-3-3, was dephosphorylated at Ser112 following rolipram/forskolin treatment of leukemic cells. Colforsin 275-284 BCL2 apoptosis regulator Homo sapiens 48-53 12531792-3 2003 Inhibitors of caspase-9, but not caspase-8, block rolipram/forskolin-induced CLL apoptosis. Colforsin 59-68 caspase 9 Homo sapiens 14-23 12531792-4 2003 In a subset of CLL patients, B-cell lymphoma 2 (Bcl-2)-associated death promoter homolog (Bad), a proapoptotic Bcl-2 family member that when phosphorylated on specific serine residues is sequestered in the cytosol by 14-3-3, was dephosphorylated at Ser112 following rolipram/forskolin treatment of leukemic cells. Colforsin 275-284 BCL2 apoptosis regulator Homo sapiens 111-116 12531792-7 2003 Rolipram/forskolin treatment augmented protein phosphatase 2A (PP2A) activity, as well as levels of immunoreactive PP2A catalytic subunit. Colforsin 9-18 protein phosphatase 2 phosphatase activator Homo sapiens 47-61 12531792-7 2003 Rolipram/forskolin treatment augmented protein phosphatase 2A (PP2A) activity, as well as levels of immunoreactive PP2A catalytic subunit. Colforsin 9-18 protein phosphatase 2 phosphatase activator Homo sapiens 63-67 12531792-7 2003 Rolipram/forskolin treatment augmented protein phosphatase 2A (PP2A) activity, as well as levels of immunoreactive PP2A catalytic subunit. Colforsin 9-18 protein phosphatase 2 phosphatase activator Homo sapiens 115-119 12531792-8 2003 Treatment of CLL cells with a concentration of okadaic acid (5 nM) that selectively inhibits PP2A, reduced both rolipram/forskolin-induced mitochondrial cytochrome c release and mitochondrial depolarization. Colforsin 121-130 protein phosphatase 2 phosphatase activator Homo sapiens 93-97 12531792-8 2003 Treatment of CLL cells with a concentration of okadaic acid (5 nM) that selectively inhibits PP2A, reduced both rolipram/forskolin-induced mitochondrial cytochrome c release and mitochondrial depolarization. Colforsin 121-130 cytochrome c, somatic Homo sapiens 153-165 12679373-8 2003 Furthermore, theophylline, as well as dibutyryl cAMP and forskolin, suppressed the LPA-induced membrane translocation of RhoA, indicating that they prevented airway hyperresponsiveness by inhibiting RhoA. Colforsin 57-66 ras homolog family member A Bos taurus 121-125 12505864-4 2003 The PTH response was dose dependent, with a half-maximal response at 5 x 10(-9) M and maximal response at 5 x 10(-8) M. Forskolin and dibutyryl-cAMP also stimulated I(sc), as did the phosphodiesterase inhibitor IBMX. Colforsin 120-129 parathyroid hormone Gallus gallus 4-7 12686464-5 2003 After treatment with 5 microM forskolin for 3 days, the concentration of the ir-relaxin 3 in the culture supernatant reached 12 nM. Colforsin 30-39 relaxin 3 Homo sapiens 80-89 12717139-12 2003 CONCLUSIONS: Benzodiazepines potentiate the effect of CRH or forskolin on proopiomelanocortin gene expression. Colforsin 61-70 pro-opiomelanocortin-alpha Mus musculus 74-93 12717139-8 2003 RESULTS: Diazepam and midazolam dose-dependently increased the proopiomelanocortin gene expression induced by CRH or forskolin. Colforsin 117-126 pro-opiomelanocortin-alpha Mus musculus 63-82 12519745-6 2003 Activation of endogenous AMPK with the cell-permeant adenosine analog 5-amino-4-imidazolecarboxamide-1-beta-d-ribofuranoside (AICAR) inhibited forskolin-stimulated CFTR-dependent I(sc) in nonpermeabilized monolayers and monolayers with nystatin permeabilization of the basolateral membrane. Colforsin 143-152 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 25-29 12519745-6 2003 Activation of endogenous AMPK with the cell-permeant adenosine analog 5-amino-4-imidazolecarboxamide-1-beta-d-ribofuranoside (AICAR) inhibited forskolin-stimulated CFTR-dependent I(sc) in nonpermeabilized monolayers and monolayers with nystatin permeabilization of the basolateral membrane. Colforsin 143-152 CF transmembrane conductance regulator Homo sapiens 164-168 12519745-8 2003 Finally, overexpression of a kinase-dead mutant AMPK-alpha1 subunit (alpha1-K45R) enhanced forskolin-stimulated I(sc) in polarized T84 monolayers, consistent with a dominant-negative reduction in the inhibition of CFTR by endogenous AMPK. Colforsin 91-100 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 48-59 12519745-8 2003 Finally, overexpression of a kinase-dead mutant AMPK-alpha1 subunit (alpha1-K45R) enhanced forskolin-stimulated I(sc) in polarized T84 monolayers, consistent with a dominant-negative reduction in the inhibition of CFTR by endogenous AMPK. Colforsin 91-100 CF transmembrane conductance regulator Homo sapiens 214-218 12519745-8 2003 Finally, overexpression of a kinase-dead mutant AMPK-alpha1 subunit (alpha1-K45R) enhanced forskolin-stimulated I(sc) in polarized T84 monolayers, consistent with a dominant-negative reduction in the inhibition of CFTR by endogenous AMPK. Colforsin 91-100 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 48-52 12697703-4 2003 We report that levels of the endogenous GnRHR mRNA in alpha T3-1 cells are stimulated by forskolin and 8-bromo-cAMP. Colforsin 89-98 gonadotropin releasing hormone receptor Mus musculus 40-45 12753864-4 2003 Using RT-PCR, we found that PTH(1-34), forskolin (FSK), and 8-bromo-cAMP (8Br-cAMP) induced ICER expression, while phorbol myristate acetate (PMA), ionomycin, and PTH(3-34) did not. Colforsin 39-48 cAMP responsive element modulator Mus musculus 92-96 12753864-4 2003 Using RT-PCR, we found that PTH(1-34), forskolin (FSK), and 8-bromo-cAMP (8Br-cAMP) induced ICER expression, while phorbol myristate acetate (PMA), ionomycin, and PTH(3-34) did not. Colforsin 50-53 cAMP responsive element modulator Mus musculus 92-96 12753864-6 2003 PKA inhibition by H89 markedly reduced PTH- and FSK-induced ICER expression, while PKC depletion by PMA had little effect. Colforsin 48-51 cAMP responsive element modulator Mus musculus 60-64 12753864-9 2003 PTHrP maximally induced ICER mRNA at 2-4 h, which then returned to baseline by 10 h. Finally, PTH, FSK, and PTHrP induced ICER in cultured mouse calvariae and osteoblastic ROS 17/2.8, UMR-106, and Pyla cells. Colforsin 99-102 parathyroid hormone-like peptide Mus musculus 0-5 12753864-9 2003 PTHrP maximally induced ICER mRNA at 2-4 h, which then returned to baseline by 10 h. Finally, PTH, FSK, and PTHrP induced ICER in cultured mouse calvariae and osteoblastic ROS 17/2.8, UMR-106, and Pyla cells. Colforsin 99-102 cAMP responsive element modulator Mus musculus 24-28 12753864-9 2003 PTHrP maximally induced ICER mRNA at 2-4 h, which then returned to baseline by 10 h. Finally, PTH, FSK, and PTHrP induced ICER in cultured mouse calvariae and osteoblastic ROS 17/2.8, UMR-106, and Pyla cells. Colforsin 99-102 cAMP responsive element modulator Mus musculus 122-126 12639716-3 2003 In the present study we show that treatment of intact mouse islets and RINm5F cells with protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) or protein kinase A (PKA) activator forskolin promoted insulin secretion with no changes of [Ca(2+)](i). Colforsin 196-205 protein kinase C, alpha Rattus norvegicus 107-110 12639716-3 2003 In the present study we show that treatment of intact mouse islets and RINm5F cells with protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) or protein kinase A (PKA) activator forskolin promoted insulin secretion with no changes of [Ca(2+)](i). Colforsin 196-205 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 163-179 12639716-3 2003 In the present study we show that treatment of intact mouse islets and RINm5F cells with protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) or protein kinase A (PKA) activator forskolin promoted insulin secretion with no changes of [Ca(2+)](i). Colforsin 196-205 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 181-184 12639716-5 2003 The secretagogue actions of PMA and forskolin were blocked by GF109203X and H89, selective inhibitors for PKC and PKA, respectively. Colforsin 36-45 protein kinase C, alpha Rattus norvegicus 106-109 12639716-5 2003 The secretagogue actions of PMA and forskolin were blocked by GF109203X and H89, selective inhibitors for PKC and PKA, respectively. Colforsin 36-45 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 114-117 12746229-13 2003 SRIF analogues inhibited the forskolin-stimulated cAMP levels depending on concentration. Colforsin 29-38 somatostatin Mus musculus 0-4 12748876-4 2003 In addition, granulosa cells obtained from the follicular fluid were cultured and treated with forskolin and 12- o-tetradecanoylphorbol 13-acetate for 24-48 h. The concentration of IL-6 was significantly higher in the follicular fluid than in the serum (P<0.01). Colforsin 95-104 interleukin 6 Homo sapiens 181-185 12748876-7 2003 The production of IL-6 was markedly increased over the basal level after 24 h of treatment with forskolin (P<0.001) and 48 h of treatment (P<0.01) with cultured granulosa cells. Colforsin 96-105 interleukin 6 Homo sapiens 18-22 12697703-8 2003 Furthermore, we show that forskolin up-regulates SF-1 mRNA levels in alpha T3-1 cells, indicating that the levels of SF-1 play a role in modulating the protein kinase A response. Colforsin 26-35 splicing factor 1 Mus musculus 49-53 12856808-2 2003 It has been shown that treatment of the SE cells with adenylyl cyclase activator, forskolin, known to stimulate the protein kinase A (PKA) pathway, resulted in an increase in 11betaHSD2 mRNA content in these cells. Colforsin 82-91 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 116-132 12697703-8 2003 Furthermore, we show that forskolin up-regulates SF-1 mRNA levels in alpha T3-1 cells, indicating that the levels of SF-1 play a role in modulating the protein kinase A response. Colforsin 26-35 splicing factor 1 Mus musculus 117-121 12856808-2 2003 It has been shown that treatment of the SE cells with adenylyl cyclase activator, forskolin, known to stimulate the protein kinase A (PKA) pathway, resulted in an increase in 11betaHSD2 mRNA content in these cells. Colforsin 82-91 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 134-137 12692270-7 2003 VR-1 activation that resulted in HSV-1 reactivation was calcium-dependent, since the calcium chelator BAPTA significantly reduced reactivation following treatment with caspsaicin and forskolin. Colforsin 183-192 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-4 12856808-2 2003 It has been shown that treatment of the SE cells with adenylyl cyclase activator, forskolin, known to stimulate the protein kinase A (PKA) pathway, resulted in an increase in 11betaHSD2 mRNA content in these cells. Colforsin 82-91 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 175-185 12856808-3 2003 Semi-quantitative RT-PCR revealed that the effect of forskolin was attenuated by the addition of phorbol ester, tetradecanoyl phorbol acetate (TPA), an activator of the protein kinase C (PKC) pathway, whereas TPA on its own slightly reduced the basal level of 11betaHSD2 expression judging from the content of specific mRNA. Colforsin 53-62 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 260-270 12856808-4 2003 Measurements of [35S]-methionine incorporation into immunoprecipitable 11betaHSD2 revealed an increased synthesis of this protein in renal epithelial cells treated with forskolin. Colforsin 169-178 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 71-81 12856808-5 2003 Phorbol ester TPA markedly reduced the effect of forskolin on the synthesis of 11betaHSD2 and attenuated the basal level of synthesis of this protein. Colforsin 49-58 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 79-89 12727988-2 2003 In the present work we demonstrate that highly luteinized human granulosa cells obtained from in vitro fertilization patients respond to human LH as well as to forskolin in phosphorylation of extracellular-signal regulated kinases 1 and 2 (ERK1 and -2). Colforsin 160-169 mitogen-activated protein kinase 1 Homo sapiens 192-238 12727988-2 2003 In the present work we demonstrate that highly luteinized human granulosa cells obtained from in vitro fertilization patients respond to human LH as well as to forskolin in phosphorylation of extracellular-signal regulated kinases 1 and 2 (ERK1 and -2). Colforsin 160-169 mitogen-activated protein kinase 3 Homo sapiens 240-251 12694408-2 2003 Forskolin treatment of cells transfected with the rat PNMT promoter-luciferase reporter gene construct pGL3RP893 increased promoter activity approximately two-fold whereas phorbol-12-myristate-13 acetate (PMA) treatment had no effect. Colforsin 0-9 phenylethanolamine-N-methyltransferase Rattus norvegicus 54-58 12694408-3 2003 However, simultaneous forskolin and PMA treatment synergistically activated the PNMT promoter approximately four-fold, suggesting that PKC stimulation requires prior induction of the PKA pathway. Colforsin 22-31 phenylethanolamine-N-methyltransferase Rattus norvegicus 80-84 12692897-5 2003 The effect of PACAP on cell survival was mimicked by dibutyryl-cAMP (dbcAMP) and forskolin and prevented by the MEK inhibitor U0126, indicating that both the adenylyl-cyclase and MAP-kinase pathways contribute to the neuroprotective action of the peptide. Colforsin 81-90 adenylate cyclase activating polypeptide 1 Homo sapiens 14-19 12694408-4 2003 Consistent with this possibility the adenylate cyclase inhibitor MDL12,330A, and the PKA inhibitor H-89 prevented PNMT promoter stimulation by the combination of forskolin and PMA. Colforsin 162-171 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 85-88 12694408-3 2003 However, simultaneous forskolin and PMA treatment synergistically activated the PNMT promoter approximately four-fold, suggesting that PKC stimulation requires prior induction of the PKA pathway. Colforsin 22-31 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 183-186 12694408-4 2003 Consistent with this possibility the adenylate cyclase inhibitor MDL12,330A, and the PKA inhibitor H-89 prevented PNMT promoter stimulation by the combination of forskolin and PMA. Colforsin 162-171 phenylethanolamine-N-methyltransferase Rattus norvegicus 114-118 12667634-5 2003 Levels of AT(1A)R mRNA were dose-dependently lowered by AM, with a maximal 40-50% inhibition by 6 h. The decreases in both AT(1)R binding and AT(1A)R mRNA levels were mimicked by 8-Br-cAMP or forskolin, suggesting that the effects of AM were mediated via an elevation of cAMP. Colforsin 192-201 angiotensin II receptor type 1 Homo sapiens 123-129 12694408-6 2003 Forskolin and PMA treatment of PC12 cells increased Egr-1 protein and phosphorylated Egr-1/DNA-binding complex formation to the same extent but only increased phosphorylated Sp1/DNA binding complex formation without altering Sp1 protein levels. Colforsin 0-9 early growth response 1 Rattus norvegicus 52-57 12694408-6 2003 Forskolin and PMA treatment of PC12 cells increased Egr-1 protein and phosphorylated Egr-1/DNA-binding complex formation to the same extent but only increased phosphorylated Sp1/DNA binding complex formation without altering Sp1 protein levels. Colforsin 0-9 early growth response 1 Rattus norvegicus 85-90 12694408-7 2003 Mutation of the - 165 bp Egr-1 and - 48 bp Sp1 sites, respectively, attenuated and abolished combined forskolin and PMA-mediated promoter activation. Colforsin 102-111 early growth response 1 Rattus norvegicus 25-39 12842460-9 2003 The amount of HSP20 that immunoprecipitated with alpha -actinin was markedly diminished in muscles that were treated with the vasorelaxant forskolin. Colforsin 139-148 heat shock protein beta-6 Bos taurus 14-19 12902638-14 2003 In arteries activated with vasopressin and exposed to either forskolin or sodium nitroprusside, the addition of NPY evoked contractions which were more pronounced in arteries from SHR compared to WKY arteries. Colforsin 61-70 neuropeptide Y Rattus norvegicus 112-115 12716456-7 2003 CONCLUSION: These results demonstrate that multiple mechanisms can induce force suppression that is correlated with ser16-HSP20 phosphorylation: 1) nitrovasodilators via cGMP, 2) forskolin via cAMP, and 2) thermal stress in a cyclic nucleotide independent manner. Colforsin 179-188 HSPB6 Sus scrofa 122-127 12456386-7 2003 Renal cortical cells in culture from animals receiving only saline exhibited increased levels of renin mRNA when treated with isoproterenol, forskolin, or IBMX. Colforsin 141-150 renin Ovis aries 97-102 12566449-2 2003 In transient transfections, forskolin plus 3-isobutyl-1-methylxanthine (IBMX), which increases intracellular cAMP, stimulated the transcriptional activities of both ER alpha and ER beta. Colforsin 28-37 estrogen receptor 1 Gallus gallus 165-173 12566449-2 2003 In transient transfections, forskolin plus 3-isobutyl-1-methylxanthine (IBMX), which increases intracellular cAMP, stimulated the transcriptional activities of both ER alpha and ER beta. Colforsin 28-37 estrogen receptor 2 Gallus gallus 178-185 12566449-7 2003 The E/F domains of ER alpha are sufficient for activation by forskolin/IBMX, and this is accompanied by an increase in receptor phosphorylation. Colforsin 61-70 estrogen receptor 1 Gallus gallus 19-27 12566449-8 2003 In contrast, cAMP signaling reduces the phosphorylation of the corresponding region of ER beta, and this correlates with the lack of forskolin/IBMX stimulated transcriptional activity. Colforsin 133-142 estrogen receptor 2 Gallus gallus 87-94 12566449-10 2003 Moreover, differences in the cofactor requirements, domains of ER alpha and ER beta sufficient for forskolin/IBMX activation, and the effect of cAMP on receptor phosphorylation indicate that this signaling pathway utilizes distinct mechanisms to stimulate ER alpha and ER beta transcriptional activity. Colforsin 99-108 estrogen receptor 2 Gallus gallus 76-83 12672250-10 2003 In addition, TCPA was a full agonist and inhibited the forskolin-induced cAMP production of CHO cells stably transfected with the human adenosine A(1) receptor with an IC(50) of 1.5 +/- 0.5 nM. Colforsin 55-64 adenosine A1 receptor Homo sapiens 136-159 12456386-8 2003 Only forskolin increased renin mRNA levels in renal cortical cells in culture from animals receiving COX-2 inhibitor. Colforsin 5-14 renin Ovis aries 25-30 12456386-8 2003 Only forskolin increased renin mRNA levels in renal cortical cells in culture from animals receiving COX-2 inhibitor. Colforsin 5-14 cytochrome c oxidase subunit II Ovis aries 101-106 12594185-5 2003 PGE2, forskolin, and retinoic acid induced a time-dependent up-regulation of Stra13 mRNA and protein expression in podocytes. Colforsin 6-15 basic helix-loop-helix family member e40 Homo sapiens 77-83 12712100-11 2003 After forskolin treatment for 2 hours, aquaporin 8 messenger RNA expression in WISH cells increased 4-fold (P <.001). Colforsin 6-15 aquaporin 8 Homo sapiens 39-50 12651617-7 2003 Moreover, the forskolin-mediated increases in intracellular cAMP concentrations were inhibited by the ligands for CCR1, CCL3, CCL4, and CCL5, suggesting that the expressed CCR1 was functional. Colforsin 14-23 C-C motif chemokine receptor 1 Homo sapiens 114-118 12651617-7 2003 Moreover, the forskolin-mediated increases in intracellular cAMP concentrations were inhibited by the ligands for CCR1, CCL3, CCL4, and CCL5, suggesting that the expressed CCR1 was functional. Colforsin 14-23 C-C motif chemokine ligand 3 Homo sapiens 120-124 12651617-7 2003 Moreover, the forskolin-mediated increases in intracellular cAMP concentrations were inhibited by the ligands for CCR1, CCL3, CCL4, and CCL5, suggesting that the expressed CCR1 was functional. Colforsin 14-23 C-C motif chemokine ligand 4 Homo sapiens 126-130 12651617-7 2003 Moreover, the forskolin-mediated increases in intracellular cAMP concentrations were inhibited by the ligands for CCR1, CCL3, CCL4, and CCL5, suggesting that the expressed CCR1 was functional. Colforsin 14-23 C-C motif chemokine ligand 5 Homo sapiens 136-140 12651617-7 2003 Moreover, the forskolin-mediated increases in intracellular cAMP concentrations were inhibited by the ligands for CCR1, CCL3, CCL4, and CCL5, suggesting that the expressed CCR1 was functional. Colforsin 14-23 C-C motif chemokine receptor 1 Homo sapiens 172-176 12655167-5 2003 The inhibitory action of TNF-alpha was also observed when I(Cl) had been previously stimulated by 1 micromol/L forskolin (n=5). Colforsin 111-120 tumor necrosis factor Cavia porcellus 25-34 12639912-2 2003 In 4B cells transfected with a CRH promoter-luciferase construct, the adenylyl cyclase stimulator, forskolin, increased luciferase activity in parallel with increases in intracellular cAMP. Colforsin 99-108 corticotropin releasing hormone Mus musculus 31-34 12648265-5 2003 The VIP-induced vasodilation was potentiated by forskolin (an adenylate cyclase stimulator) and partly reduced by l-NMMA or S-methyl-l-thiocitrulline (l-SMTC, a neuronal NO synthase inhibitor), whereas it was unaffected by indomethacin. Colforsin 48-57 VIP peptides Oryctolagus cuniculus 4-7 12679459-5 2003 Increasing cAMP by forskolin caused a protein kinase A-dependent increase of ERK activity (287 +/- 37%) in GH-omas and had no effect in NFPA. Colforsin 19-28 mitogen-activated protein kinase 1 Homo sapiens 77-80 12778365-7 2003 Moreover, stimulation of Gs-proteins with cholera toxin and adenylyl cyclase with forskolin and dibutyryl-cAMP dramatically downregulated AQPap mRNA. Colforsin 82-91 aquaporin 7 Homo sapiens 138-143 12646616-7 2003 Pretreatment of T cells with 8-bromo cAMP, forskolin, or 3-isobutyl-1-methylxanthine prevented the CD47-mediated apoptosis, and 1F7 dramatically reduced intracellular cAMP levels, an effect reversed with PTX. Colforsin 43-52 CD47 molecule Homo sapiens 99-103 12600897-7 2003 Forskolin, an activator of cAMP synthesis, considerably stimulates renin synthesis via inhibition of REN mRNA decay. Colforsin 0-9 renin Homo sapiens 67-72 12668733-5 2003 The NPo in cell-attached patches was not modified when tubules were preincubated in the presence of 10-5 M forskolin, but the channel was inhibited by phorbol ester (10-6 M). Colforsin 107-116 RNA binding motif protein 19 Mus musculus 4-7 12727446-4 2003 Similarly, the inhibition of translation of all hh genes and the perturbation of Shh signaling by forskolin resulted in a decrease in the number of cells. Colforsin 98-107 sonic hedgehog signaling molecule a Danio rerio 81-84 12646212-5 2003 Nicotinic acid and Acipimox inhibit forskolin-stimulated intracellular cAMP accumulation in human HM74b-expressing cells and activate GTP gamma S binding in a dose-dependent manner. Colforsin 36-45 hydroxycarboxylic acid receptor 2 Homo sapiens 98-103 12706289-9 2003 Bypassing the GHRH receptor through treatment with forskolin and 3-isobutyl-1-methylxanthine (IBMX) and phorbol 12-myristate-13-acetate failed to increase GH mRNA levels, suggesting that a lack of GHRH receptors alone cannot account for the lack of GHRH responses in the absence of CORT. Colforsin 51-60 growth hormone releasing hormone Gallus gallus 14-18 12623129-8 2003 Forskolin, a direct activator of adenylyl cyclase, and dibutyryl cAMP, a cell-permeable cAMP analogue-induced COX-2 mRNA, suggesting a cAMP-dependent COX-2 expression in hSMC. Colforsin 0-9 prostaglandin-endoperoxide synthase 2 Homo sapiens 150-155 12682798-4 2003 Stimulation of purinergic receptors by ATP/UTP or activation of CFTR by IBMX and forskolin inhibited amiloride-sensitive transport in mouse trachea and colon, respectively, by a mechanism that was Cl- dependent. Colforsin 81-90 cystic fibrosis transmembrane conductance regulator Mus musculus 64-68 12682798-7 2003 When coexpressed in Xenopus oocytes, activation of CFTR by IBMX and forskolin inhibited the epithelial Na+ channel (ENaC) in a Cl- dependent fashion. Colforsin 68-77 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 51-55 12682798-7 2003 When coexpressed in Xenopus oocytes, activation of CFTR by IBMX and forskolin inhibited the epithelial Na+ channel (ENaC) in a Cl- dependent fashion. Colforsin 68-77 sodium channel, nonvoltage-gated 1 alpha Mus musculus 116-120 12600897-7 2003 Forskolin, an activator of cAMP synthesis, considerably stimulates renin synthesis via inhibition of REN mRNA decay. Colforsin 0-9 renin Homo sapiens 101-104 12604622-5 2003 Chronic TNFalpha exposure led to a dose- and time-dependent increase in basal-, GTP-, NaF-, and forskolin-stimulated adenylyl cyclase (AC) activity. Colforsin 96-105 tumor necrosis factor Homo sapiens 8-16 12766480-4 2003 Similarly to serum deprivation, apoptosis triggered by [(3)H]-thymidine labeling was sharply potentiated by VSMC transfection with a functional analogue of c-myc, E1A-adenoviral protein (VSMC-E1A), and was suppressed by stimulation of cAMP signaling with forskolin as well as by and Na/K pump inhibition with ouabain. Colforsin 255-264 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 156-161 12892052-4 2003 Here we report that the culture of an antigen or anti-CD3-activated murine Th1 clone with the adenylcyclase agonist forskolin (FSK) in the absence of antigen reduces the activity of intracellular catalase, and diminishes levels of intracellular reduced glutathione (GSH). Colforsin 116-125 negative elongation factor complex member C/D, Th1l Mus musculus 75-78 12892052-4 2003 Here we report that the culture of an antigen or anti-CD3-activated murine Th1 clone with the adenylcyclase agonist forskolin (FSK) in the absence of antigen reduces the activity of intracellular catalase, and diminishes levels of intracellular reduced glutathione (GSH). Colforsin 127-130 negative elongation factor complex member C/D, Th1l Mus musculus 75-78 12737320-6 2003 Pre-treatment of CB1-VR1-HEK cells with forskolin, an adenylate cyclase activator, enhanced the capsaicin effect on [Ca2+]i. HU-210, which in the same cells inhibits forskolin-induced enhancement of cAMP levels, blocked the stimulatory effect of forskolin on capsaicin. Colforsin 40-49 cannabinoid receptor 1 Homo sapiens 17-24 12737320-6 2003 Pre-treatment of CB1-VR1-HEK cells with forskolin, an adenylate cyclase activator, enhanced the capsaicin effect on [Ca2+]i. HU-210, which in the same cells inhibits forskolin-induced enhancement of cAMP levels, blocked the stimulatory effect of forskolin on capsaicin. Colforsin 166-175 cannabinoid receptor 1 Homo sapiens 17-24 12586760-12 2003 Consistent with this possibility, we find that the ability of forskolin and membrane-permeable forms of cAMP to inhibit the GnRH response of the GnRHR promoter is associated with a loss of both JNK activation and GnRH-mediated recruitment of the primary AP-1-binding components. Colforsin 62-71 gonadotropin releasing hormone 1 Mus musculus 124-128 12737320-6 2003 Pre-treatment of CB1-VR1-HEK cells with forskolin, an adenylate cyclase activator, enhanced the capsaicin effect on [Ca2+]i. HU-210, which in the same cells inhibits forskolin-induced enhancement of cAMP levels, blocked the stimulatory effect of forskolin on capsaicin. Colforsin 166-175 cannabinoid receptor 1 Homo sapiens 17-24 12586760-12 2003 Consistent with this possibility, we find that the ability of forskolin and membrane-permeable forms of cAMP to inhibit the GnRH response of the GnRHR promoter is associated with a loss of both JNK activation and GnRH-mediated recruitment of the primary AP-1-binding components. Colforsin 62-71 jun proto-oncogene Mus musculus 254-258 12586779-7 2003 In cultured granulosa cells, forskolin and phorbol 12 myristate 13-acetate or FSH + testosterone increased expression of versican. Colforsin 29-38 versican Mus musculus 121-129 12586783-6 2003 Glyburide also blocked the glucocorticoid inhibition of forskolin-stimulated ACTH release from pituitary tissue in vitro. Colforsin 56-65 pro-opiomelanocortin-alpha Mus musculus 77-81 12586760-12 2003 Consistent with this possibility, we find that the ability of forskolin and membrane-permeable forms of cAMP to inhibit the GnRH response of the GnRHR promoter is associated with a loss of both JNK activation and GnRH-mediated recruitment of the primary AP-1-binding components. Colforsin 62-71 gonadotropin releasing hormone receptor Mus musculus 145-150 12586760-12 2003 Consistent with this possibility, we find that the ability of forskolin and membrane-permeable forms of cAMP to inhibit the GnRH response of the GnRHR promoter is associated with a loss of both JNK activation and GnRH-mediated recruitment of the primary AP-1-binding components. Colforsin 62-71 mitogen-activated protein kinase 8 Mus musculus 194-197 12586760-12 2003 Consistent with this possibility, we find that the ability of forskolin and membrane-permeable forms of cAMP to inhibit the GnRH response of the GnRHR promoter is associated with a loss of both JNK activation and GnRH-mediated recruitment of the primary AP-1-binding components. Colforsin 62-71 gonadotropin releasing hormone 1 Mus musculus 145-149 12620479-9 2003 Forskolin inhibited MMP-9 activity and increased TIMP-1 and progesterone secretion in both groups. Colforsin 0-9 matrix metallopeptidase 9 Homo sapiens 20-25 12620479-9 2003 Forskolin inhibited MMP-9 activity and increased TIMP-1 and progesterone secretion in both groups. Colforsin 0-9 TIMP metallopeptidase inhibitor 1 Homo sapiens 49-55 12734776-9 2003 Treatment of explants with agents that increase cAMP (isobutylmethylxanthine and forskolin) prevented TNFalpha production and expression and culture-induced alterations of adipocyte gene expression. Colforsin 81-90 tumor necrosis factor Homo sapiens 102-110 12554794-5 2003 The effect of PTH was mimicked by forskolin, an activator of adenylate cyclase leading to the protein kinase A pathway. Colforsin 34-43 parathyroid hormone Rattus norvegicus 14-17 12614345-10 2003 In OPCs the group II mGluR agonist (2S,2"R,3"R)-2-(2",3"-dicarboxycyclopropyl)glycine (DCG-IV) decreased forskolin-stimulated cAMP synthesis, indicating the presence of functional mGluR3. Colforsin 105-114 glutamate receptor, ionotropic, AMPA3 (alpha 3) Mus musculus 180-186 12603835-9 2003 This was confirmed by the unique induction of RGS2 (+ 111.1%) observed in the periventricular zone of the striatum after intracerebroventricular injection of forskolin. Colforsin 158-167 regulator of G protein signaling 2 Homo sapiens 46-50 12554796-3 2003 Forskolin/phorbol myristate (PMA) induced PR promoter-luciferase reporter activity in granulosa cells greater than 15-fold. Colforsin 0-9 progesterone receptor Mus musculus 42-44 12468529-6 2003 Suppression of AQP1 expression in cholangiocytes resulted in a decrease in water transport by IBDUs in response to both an inward osmotic gradient (200 mosm) or a secretory agonist (forskolin), the osmotic water permeability coefficient (P(f)) decreasing up to 58.8% and net water secretion (J(v)) decreasing up to 87%. Colforsin 182-191 aquaporin 1 Rattus norvegicus 15-19 12493747-4 2003 Interestingly enough, treatment of Jurkat cells with cyclic AMP-elevating agents such as forskolin, in combination with bpV, resulted in a more important COX-2 transcriptional activation. Colforsin 89-98 prostaglandin-endoperoxide synthase 2 Homo sapiens 154-159 12651911-8 2003 Substantial qualitative and quantitative differences in PSA expression and AR occupancy of the PSA enhancer were observed when DHT-induced and ligand-independent activations of the AR were compared; forskolin stimulated PSA mRNA and protein expression, whereas IL-6 inhibited both DHT- and forskolin-stimulated expression. Colforsin 199-208 kallikrein related peptidase 3 Homo sapiens 56-59 12651911-8 2003 Substantial qualitative and quantitative differences in PSA expression and AR occupancy of the PSA enhancer were observed when DHT-induced and ligand-independent activations of the AR were compared; forskolin stimulated PSA mRNA and protein expression, whereas IL-6 inhibited both DHT- and forskolin-stimulated expression. Colforsin 199-208 kallikrein related peptidase 3 Homo sapiens 95-98 12651911-8 2003 Substantial qualitative and quantitative differences in PSA expression and AR occupancy of the PSA enhancer were observed when DHT-induced and ligand-independent activations of the AR were compared; forskolin stimulated PSA mRNA and protein expression, whereas IL-6 inhibited both DHT- and forskolin-stimulated expression. Colforsin 199-208 kallikrein related peptidase 3 Homo sapiens 95-98 12651911-8 2003 Substantial qualitative and quantitative differences in PSA expression and AR occupancy of the PSA enhancer were observed when DHT-induced and ligand-independent activations of the AR were compared; forskolin stimulated PSA mRNA and protein expression, whereas IL-6 inhibited both DHT- and forskolin-stimulated expression. Colforsin 199-208 interleukin 6 Homo sapiens 261-265 12651911-8 2003 Substantial qualitative and quantitative differences in PSA expression and AR occupancy of the PSA enhancer were observed when DHT-induced and ligand-independent activations of the AR were compared; forskolin stimulated PSA mRNA and protein expression, whereas IL-6 inhibited both DHT- and forskolin-stimulated expression. Colforsin 290-299 kallikrein related peptidase 3 Homo sapiens 95-98 12651911-8 2003 Substantial qualitative and quantitative differences in PSA expression and AR occupancy of the PSA enhancer were observed when DHT-induced and ligand-independent activations of the AR were compared; forskolin stimulated PSA mRNA and protein expression, whereas IL-6 inhibited both DHT- and forskolin-stimulated expression. Colforsin 290-299 kallikrein related peptidase 3 Homo sapiens 95-98 12589790-3 2003 Chemical inhibition of PKA suppressed forskolin-induced EGFR tyrosine phosphorylation and ERK1/2 activation in PC12 cells. Colforsin 38-47 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 23-26 12589790-3 2003 Chemical inhibition of PKA suppressed forskolin-induced EGFR tyrosine phosphorylation and ERK1/2 activation in PC12 cells. Colforsin 38-47 epidermal growth factor receptor Rattus norvegicus 56-60 12589818-7 2003 Adiponectin secretion was also inhibited between 25% and 45% by chronic treatment with forskolin (50 microM), tumor necrosis factor alpha (100 ng/ml), and dexamethasone (100 nM). Colforsin 87-96 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 12589790-3 2003 Chemical inhibition of PKA suppressed forskolin-induced EGFR tyrosine phosphorylation and ERK1/2 activation in PC12 cells. Colforsin 38-47 mitogen activated protein kinase 3 Rattus norvegicus 90-96 12589790-5 2003 Forskolin-induced EGFR tyrosine phosphorylation was also observed in A431 cells and in membranes isolated from these cells. Colforsin 0-9 epidermal growth factor receptor Rattus norvegicus 18-22 12421748-4 2003 Taurochenodeoxycholate and tauroursodeoxycholate increased forskolin-induced cAMP accumulation to a similar extent, without affecting cAMP basal levels. Colforsin 59-68 cathelicidin antimicrobial peptide Homo sapiens 77-81 12578987-6 2003 Neither mutation interfered with receptor surface expression but both altered function, since ADP inhibited the forskolin-induced increase of cAMP markedly less in cells transfected with either mutant P2Y(12) as compared with wild-type receptor. Colforsin 112-121 purinergic receptor P2Y12 Homo sapiens 201-208 12571360-8 2003 Western blot analysis of subcellular fractions demonstrated translocation of BIG2 (and BIG1) from cytosol to the Golgi and other membrane structures after incubation of cells with 8-Br-cAMP or forskolin. Colforsin 193-202 ADP ribosylation factor guanine nucleotide exchange factor 2 Homo sapiens 77-81 12571360-8 2003 Western blot analysis of subcellular fractions demonstrated translocation of BIG2 (and BIG1) from cytosol to the Golgi and other membrane structures after incubation of cells with 8-Br-cAMP or forskolin. Colforsin 193-202 ADP ribosylation factor guanine nucleotide exchange factor 1 Homo sapiens 87-91 12533312-7 2003 In addition, a Grb2-SOS inhibitor (SH(3)b-p peptide), a RAS inhibitor (farnesyl transferase inhibitor 277), and a RAF-1 inhibitor (forskolin) each prevented FGF-10-induced extracellular signal-regulated kinase (ERK) 1/2 phosphorylation in AEC. Colforsin 131-140 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 114-119 12533312-7 2003 In addition, a Grb2-SOS inhibitor (SH(3)b-p peptide), a RAS inhibitor (farnesyl transferase inhibitor 277), and a RAF-1 inhibitor (forskolin) each prevented FGF-10-induced extracellular signal-regulated kinase (ERK) 1/2 phosphorylation in AEC. Colforsin 131-140 fibroblast growth factor 10 Homo sapiens 157-163 12710532-6 2003 In VSMCs with low or no NPY responsiveness, pre-exposure to beta-adrenergic receptor agonist (isoproterenol), forskolin, or dibutyryl cAMP augmented NPY"s mitogenic effect, while upregulating Y1, Y2, and Y5 receptor expression (isoproterenol only). Colforsin 110-119 neuropeptide Y Rattus norvegicus 149-152 12393539-3 2003 Here, using primary human T lymphocytes in which endogenous cAMP was increased by the use of forskolin and 3-isobutyl-1-methylxanthine (IBMX), we show that increase of cAMP resulted in inhibition of T-cell receptor (TCR)/CD3 plus CD28-mediated T-cell activation and cytokine production and blockade of cell cycle progression at the G(1) phase. Colforsin 93-102 cathelicidin antimicrobial peptide Homo sapiens 60-64 12393539-3 2003 Here, using primary human T lymphocytes in which endogenous cAMP was increased by the use of forskolin and 3-isobutyl-1-methylxanthine (IBMX), we show that increase of cAMP resulted in inhibition of T-cell receptor (TCR)/CD3 plus CD28-mediated T-cell activation and cytokine production and blockade of cell cycle progression at the G(1) phase. Colforsin 93-102 cathelicidin antimicrobial peptide Homo sapiens 168-172 12393539-3 2003 Here, using primary human T lymphocytes in which endogenous cAMP was increased by the use of forskolin and 3-isobutyl-1-methylxanthine (IBMX), we show that increase of cAMP resulted in inhibition of T-cell receptor (TCR)/CD3 plus CD28-mediated T-cell activation and cytokine production and blockade of cell cycle progression at the G(1) phase. Colforsin 93-102 CD28 molecule Homo sapiens 230-234 12641353-12 2003 Forskolin administration was associated with release of cyclic AMP from the heart and completely inhibited LPS-stimulated TNF release. Colforsin 0-9 tumor necrosis factor Rattus norvegicus 122-125 12641353-15 2003 Elevating myocardial cyclic AMP with forskolin completely attenuated LPS-stimulated TNF release. Colforsin 37-46 tumor necrosis factor Rattus norvegicus 84-87 12710532-6 2003 In VSMCs with low or no NPY responsiveness, pre-exposure to beta-adrenergic receptor agonist (isoproterenol), forskolin, or dibutyryl cAMP augmented NPY"s mitogenic effect, while upregulating Y1, Y2, and Y5 receptor expression (isoproterenol only). Colforsin 110-119 neuropeptide Y receptor Y5 Rattus norvegicus 204-215 12464395-7 2003 Treatment of cells with forskolin, a stimulator of adenylate cyclase, increased the amount of phosphorylated CREB and CBP, but not the amount of phosphorylated Smad2 bound in a complex to the SBE. Colforsin 24-33 cAMP responsive element binding protein 1 Mus musculus 109-113 12538618-9 2003 The presence of insulin in the culture medium converted forskolin from a stimulator to an inhibitor in FRTL-5 cells maintained in low serum conditions, but not in porcine thyrocytes in primary culture. Colforsin 56-65 insulin Sus scrofa 16-23 12464395-7 2003 Treatment of cells with forskolin, a stimulator of adenylate cyclase, increased the amount of phosphorylated CREB and CBP, but not the amount of phosphorylated Smad2 bound in a complex to the SBE. Colforsin 24-33 CREB binding protein Mus musculus 118-121 12464395-9 2003 Amounts of c-Ski and SnoN found in the SBE-containing complex increased in response to either TGFbeta or forskolin. Colforsin 105-114 ski sarcoma viral oncogene homolog (avian) Mus musculus 11-16 12464395-9 2003 Amounts of c-Ski and SnoN found in the SBE-containing complex increased in response to either TGFbeta or forskolin. Colforsin 105-114 SKI-like Mus musculus 21-25 12538618-1 2003 Insulin and forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and porcine thyrocytes. Colforsin 12-21 dual oxidase 2 Rattus norvegicus 36-41 12538609-8 2003 The differential regulation of the two beta-subunits by hCG could be mimicked by 3-isobutyl-1-methylxanthine, forskolin, and dibutyryl-cAMP, suggesting involvement of the intracellular cAMP pathway. Colforsin 110-119 chorionic gonadotropin subunit beta 5 Homo sapiens 56-59 12538609-9 2003 Interestingly, H89 (a specific inhibitor of protein kinase A, PKA) could effectively block hCG- and forskolin-stimulated activin betaA expression at 10 micro M, but it was unable to reverse the inhibitory effects of hCG and forskolin on betaB expression. Colforsin 100-109 inhibin subunit beta E Homo sapiens 121-128 12509806-10 2003 In addition, the cAMP elevating agents dibutyryl cAMP and forskolin both abolished LPS-induced TNFalpha release, thus rendering unlikely the possibility that (+)WIN 55,212-2 could ablate TNFalpha release through the inhibition of adenylate cyclase via the G(i)-coupled cannabinoid receptors type 1 and 2. Colforsin 58-67 tumor necrosis factor Rattus norvegicus 95-103 12574812-4 2003 Pretreatment of thrombin-stimulated platelets with forskolin resulted in a concentration- dependent inhibition of P-selectin expression that correlated with adenylyl cyclase activity. Colforsin 51-60 coagulation factor II, thrombin Homo sapiens 16-24 12574812-4 2003 Pretreatment of thrombin-stimulated platelets with forskolin resulted in a concentration- dependent inhibition of P-selectin expression that correlated with adenylyl cyclase activity. Colforsin 51-60 selectin P Homo sapiens 114-124 12519064-3 2003 Further, (+)-5a potently stimulated GTP gamma S binding to NOP membranes (EC50 = 65 nM) and inhibited forskolin-mediated cAMP accumulation in NOP-expressing cells (EC50 = 9.1 nM) with a potency comparable to that of the natural peptide agonist N/OFQ. Colforsin 102-111 opioid related nociceptin receptor 1 Homo sapiens 142-145 12421827-3 2003 Although proglucagon transcription and GLP-1 synthesis were shown to be activated by forskolin and other protein kinase A (PKA) activators, deleting or mutating the cAMP-response element (CRE) only moderately attenuates the proglucagon gene promoter in response to PKA activation. Colforsin 85-94 glucagon Rattus norvegicus 39-44 12421827-9 2003 Furthermore, forskolin and 8-Br-cAMP phosphorylated GSK-3beta at serine 9 in intestinal proglucagon-producing cells, and both lithium and forskolin induced the accumulation of free beta-catenin in these cell lines. Colforsin 13-22 glycogen synthase kinase 3 beta Rattus norvegicus 52-61 12374804-5 2003 However, long term hypertonicity, a feature of the inner medullary interstitium, resulted in an insertion of AQP2 into the basolateral membrane of Madin-Darby canine kidney cells after acute forskolin stimulation. Colforsin 191-200 aquaporin 2 Canis lupus familiaris 109-113 12427743-8 2003 Pharmacologic activation of AMPK inhibited forskolin-stimulated CFTR short circuit currents in polarized Calu-3 cell monolayers. Colforsin 43-52 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 28-32 12427743-8 2003 Pharmacologic activation of AMPK inhibited forskolin-stimulated CFTR short circuit currents in polarized Calu-3 cell monolayers. Colforsin 43-52 CF transmembrane conductance regulator Homo sapiens 64-68 12427743-9 2003 In whole-cell patch clamp experiments, the activation of endogenous AMPK either pharmacologically or by the overexpression of an AMPK-activating non-catalytic subunit mutant (AMPK-gamma1-R70Q) dramatically inhibited forskolin-stimulated CFTR conductance in Calu-3 and CFTR-expressing Chinese hamster ovary cells. Colforsin 216-225 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 68-72 12427743-9 2003 In whole-cell patch clamp experiments, the activation of endogenous AMPK either pharmacologically or by the overexpression of an AMPK-activating non-catalytic subunit mutant (AMPK-gamma1-R70Q) dramatically inhibited forskolin-stimulated CFTR conductance in Calu-3 and CFTR-expressing Chinese hamster ovary cells. Colforsin 216-225 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 129-133 12427743-9 2003 In whole-cell patch clamp experiments, the activation of endogenous AMPK either pharmacologically or by the overexpression of an AMPK-activating non-catalytic subunit mutant (AMPK-gamma1-R70Q) dramatically inhibited forskolin-stimulated CFTR conductance in Calu-3 and CFTR-expressing Chinese hamster ovary cells. Colforsin 216-225 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 129-133 12388213-6 2003 To investigate whether the cAMP-induced Na(+)-HCO(3)(-) cotransport activation was secondary to secretion-associated changes in HCO(3)(-) or cell volume, we measured potential forskolin-induced changes in intracellular pH and assessed Na(+)-HCO(3)(-) transport activity in CFTR -/- crypts (in which no forskolin-induced cell shrinkage occurs). Colforsin 176-185 cystic fibrosis transmembrane conductance regulator Mus musculus 273-277 12485811-5 2003 To gain further insights into the effects of ACTH, cultured endothelial cells (ECs) were treated with forskolin, which increases cAMP, the second messenger in ACTH action. Colforsin 102-111 pro-opiomelanocortin-alpha Mus musculus 45-49 12485811-5 2003 To gain further insights into the effects of ACTH, cultured endothelial cells (ECs) were treated with forskolin, which increases cAMP, the second messenger in ACTH action. Colforsin 102-111 pro-opiomelanocortin-alpha Mus musculus 159-163 12485811-6 2003 We demonstrate that Flk-1/KDR protein expression was markedly increased by forskolin within 24-48 h of treatment in a dose-dependent manner (0.1-10 microM). Colforsin 75-84 kinase insert domain protein receptor Mus musculus 20-25 12485811-6 2003 We demonstrate that Flk-1/KDR protein expression was markedly increased by forskolin within 24-48 h of treatment in a dose-dependent manner (0.1-10 microM). Colforsin 75-84 kinase insert domain protein receptor Mus musculus 26-29 12421827-9 2003 Furthermore, forskolin and 8-Br-cAMP phosphorylated GSK-3beta at serine 9 in intestinal proglucagon-producing cells, and both lithium and forskolin induced the accumulation of free beta-catenin in these cell lines. Colforsin 13-22 catenin beta 1 Rattus norvegicus 181-193 12421827-9 2003 Furthermore, forskolin and 8-Br-cAMP phosphorylated GSK-3beta at serine 9 in intestinal proglucagon-producing cells, and both lithium and forskolin induced the accumulation of free beta-catenin in these cell lines. Colforsin 138-147 glycogen synthase kinase 3 beta Rattus norvegicus 52-61 12421827-9 2003 Furthermore, forskolin and 8-Br-cAMP phosphorylated GSK-3beta at serine 9 in intestinal proglucagon-producing cells, and both lithium and forskolin induced the accumulation of free beta-catenin in these cell lines. Colforsin 138-147 catenin beta 1 Rattus norvegicus 181-193 12401517-0 2003 Forskolin suppresses insulin gene transcription in islet beta-cells through a protein kinase A-independent pathway. Colforsin 0-9 insulin Homo sapiens 21-28 12401517-2 2003 We studied the effects of forskolin on insulin gene transcription in the INS-1 beta-cell line, confirming key results in primary cultures of human islet cells. Colforsin 26-35 insulin Homo sapiens 39-46 12401517-5 2003 When cells were treated with forskolin for 12 h, insulin promoter activity was decreased 2- to 3-fold, whereas islet amyloid polypeptide promoter activity was significantly increased. Colforsin 29-38 insulin Homo sapiens 49-56 12401517-6 2003 This effect of forskolin on the insulin gene was time- and concentration-dependent, and was mimicked by 8-bromo-cAMP. Colforsin 15-24 insulin Homo sapiens 32-39 12401517-10 2003 These results demonstrate that forskolin suppresses insulin transcription in INS-1 cells through a PKA-independent mechanism that probably involves MAP kinase signalling. Colforsin 31-40 insulin Homo sapiens 52-59 12525251-5 2003 When TGFbeta1 was added simultaneously with forskolin, the production of cortisol and 11-hydroxyandrostenedione was decreased by 85% whereas that of deoxycortisol was increased. Colforsin 44-53 transforming growth factor beta 1 Homo sapiens 5-13 14586174-8 2003 Using semi-quantitative RT-PCR we showed that PGC gene expression was up-regulated by the gastro-intestinal hormones gastrin and secretin, and forskolin which stimulates adenylate cyclase activity. Colforsin 143-152 progastricsin Rattus norvegicus 46-49 12525251-7 2003 We observed that TGFbeta1 strongly inhibits forskolin-induced steroid 11beta-hydroxylase activity and CYP11B1 mRNA levels, as well as angiotensin II-induced aldosterone synthase activity and CYP11B2 mRNA levels. Colforsin 44-53 transforming growth factor beta 1 Homo sapiens 17-25 12525251-7 2003 We observed that TGFbeta1 strongly inhibits forskolin-induced steroid 11beta-hydroxylase activity and CYP11B1 mRNA levels, as well as angiotensin II-induced aldosterone synthase activity and CYP11B2 mRNA levels. Colforsin 44-53 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 191-198 12558985-2 2003 In 5-HT5A receptors-expressing cells, accumulation of cAMP by forskolin was inhibited by 5-HT as reported previously. Colforsin 62-71 5-hydroxytryptamine receptor 5A Homo sapiens 3-9 12499933-7 2003 In the presence of c-AMP elevating agents, isobutylmethylxanthine, and forskolin, in basal medium that did not contain the hormones and growth factors, the cells became GJIC-competent and expressed connexin43 gap junction protein within 48 hours after treatment. Colforsin 71-80 gap junction protein alpha 1 Homo sapiens 198-208 12591236-11 2003 Co-incubation of cells with TNF-alpha in combination with 8-Br-cyclic AMP or forskolin inhibited migration by approximately 25 and 70%, respectively. Colforsin 77-86 tumor necrosis factor Homo sapiens 28-37 12529429-5 2003 However, a brief treatment with forskolin, which is effective for short-term potentiation and which could also activate CREB, was not sufficient to induce long-term potentiation of resealing. Colforsin 32-41 cAMP responsive element binding protein 1 Homo sapiens 120-124 12899525-12 2003 We demonstrated that forskolin (an activator of PKA) increased the AN2 basal promoter activity 50%, whereas H-89 (an inhibitor of PKA) inhibited the basal and forskolin-stimulated AN2 promoter activity 40% and 70%, respectively. Colforsin 21-30 elongator acetyltransferase complex subunit 4 Homo sapiens 67-70 12899525-12 2003 We demonstrated that forskolin (an activator of PKA) increased the AN2 basal promoter activity 50%, whereas H-89 (an inhibitor of PKA) inhibited the basal and forskolin-stimulated AN2 promoter activity 40% and 70%, respectively. Colforsin 159-168 elongator acetyltransferase complex subunit 4 Homo sapiens 180-183 12403779-8 2002 Stimulation of CFTR with forskolin markedly inhibited NBC3 activity. Colforsin 25-34 CF transmembrane conductance regulator Homo sapiens 15-19 12403779-8 2002 Stimulation of CFTR with forskolin markedly inhibited NBC3 activity. Colforsin 25-34 solute carrier family 4 member 8 Homo sapiens 54-58 14753296-5 2003 In both cell lines binding of NPY induced signal transduction, which was monitored as reduction of forskolin-induced cAMP production in an ELISA. Colforsin 99-108 neuropeptide Y Homo sapiens 30-33 12297510-3 2002 ERK5 is activated by forskolin, isoproterenol, and epinephrine in NIH3T3 cells and C2C12 myoblasts. Colforsin 21-30 mitogen-activated protein kinase 7 Mus musculus 0-4 12388073-4 2002 Neither recombinant TGF-beta nor Ad-TGF beta infection affected baseline I(sc); however, exposure to > or = 1 ng/ml TGF-beta led to a significant (30-50%) reduction in the I(sc) responses to forskolin, vasoactive intestinal peptide, and cholera toxin (agents that evoke Cl(-) secretion via cAMP mobilization) and to the cell-permeant dibutyryl cAMP. Colforsin 194-203 transforming growth factor beta 1 Homo sapiens 119-127 12386156-6 2002 Oocytes co-injected with both G551D-CFTR and ENaC expressed an amiloride-sensitive whole cell current that was similar to that observed before and after G551D-CFTR activation with forskolin/isobutylmethylxanthine. Colforsin 180-189 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 36-40 12386156-6 2002 Oocytes co-injected with both G551D-CFTR and ENaC expressed an amiloride-sensitive whole cell current that was similar to that observed before and after G551D-CFTR activation with forskolin/isobutylmethylxanthine. Colforsin 180-189 sodium channel, nonvoltage-gated 1 alpha Mus musculus 45-49 12386156-6 2002 Oocytes co-injected with both G551D-CFTR and ENaC expressed an amiloride-sensitive whole cell current that was similar to that observed before and after G551D-CFTR activation with forskolin/isobutylmethylxanthine. Colforsin 180-189 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 159-163 12361948-8 2002 In contrast, a PKA stimulator, forskolin, reduced VWF binding and VWF-induced platelet agglutination, which was reversed by PKI. Colforsin 31-40 von Willebrand factor Cricetulus griseus 50-53 12361948-8 2002 In contrast, a PKA stimulator, forskolin, reduced VWF binding and VWF-induced platelet agglutination, which was reversed by PKI. Colforsin 31-40 von Willebrand factor Cricetulus griseus 66-69 12368283-9 2002 PMCA activity, when isolated pharmacologically, was also potentiated ( approximately 2-fold) by forskolin. Colforsin 96-105 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 0-4 12368283-11 2002 Finally, in situ phosphorylation assays demonstrated that PMCA was phosphorylated by treatment with forskolin but only in the presence of carbamylcholine (carbachol). Colforsin 100-109 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 58-62 12388381-6 2002 8-Bromo-cAMP, AVP, PGE(2), and forskolin increased I(SC); the current was reduced by blocking PKA, apical Cl- channels, basolateral NKCC1 (a Na+ - K+ - 2Cl- cotransporter), and basolateral Cl-/HCO(3)(-) exchangers. Colforsin 31-40 solute carrier family 12 member 2 Homo sapiens 132-137 12533784-9 2002 Glibenclamide, NPPB, DPC and DMA inhibited the forskolin-induced decrease. Colforsin 47-56 natriuretic peptide B Rattus norvegicus 15-19 12419709-10 2002 Moreover, Fsk induced phosphorylation of Raf-1 at serine-259. Colforsin 10-13 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 41-46 12454270-7 2002 Forskolin, a known cAMP regulator, increased both cellular cholesterol efflux and ABCA1 phosphorylation. Colforsin 0-9 ATP binding cassette subfamily A member 1 Homo sapiens 82-87 12533784-10 2002 Forskolin evokes the clearance of fluorescent dyes from duct space possibly due to fluid secretion in rat parotid ducts, associated with secretion through CFTR and DPC-sensitive anion channels of carbonic anhydrase-dependent bicarbonate linked with the Na+/H+ exchange mechanism. Colforsin 0-9 CF transmembrane conductance regulator Rattus norvegicus 155-159 12223484-8 2002 Exposure of TSHR(GFP/Myc) cells to forskolin or cytochalasin D caused no change in the FRET index, confirming that the decrease in the oligomeric complexes was a receptor-dependent phenomenon and free of energy or microtuble requirements. Colforsin 35-44 thyroid stimulating hormone receptor Homo sapiens 12-16 12451123-5 2002 The LIM domain proteins cysteine-rich protein-1 (CRP1) and CRP2 are expressed in sciatic nerve and induced by forskolin in cultured Schwann cells, but only CRP2 requires pou3f1 for normal expression. Colforsin 110-119 cysteine rich protein 1 Homo sapiens 24-47 12451123-5 2002 The LIM domain proteins cysteine-rich protein-1 (CRP1) and CRP2 are expressed in sciatic nerve and induced by forskolin in cultured Schwann cells, but only CRP2 requires pou3f1 for normal expression. Colforsin 110-119 cysteine rich protein 1 Homo sapiens 49-53 12451123-5 2002 The LIM domain proteins cysteine-rich protein-1 (CRP1) and CRP2 are expressed in sciatic nerve and induced by forskolin in cultured Schwann cells, but only CRP2 requires pou3f1 for normal expression. Colforsin 110-119 cysteine rich protein 2 Homo sapiens 59-63 12446019-3 2002 A mechanistic analysis revealed that the cAMP analog, dibutyryl cyclic AMP (dbcAMP), or the adenyl cyclase activator, forskolin, effectively suppressed the stimulant-induced TNF-alpha production by reducing the nuclear translocation and DNA binding activity of NF-kappaB. Colforsin 118-127 tumor necrosis factor Homo sapiens 174-183 12446019-3 2002 A mechanistic analysis revealed that the cAMP analog, dibutyryl cyclic AMP (dbcAMP), or the adenyl cyclase activator, forskolin, effectively suppressed the stimulant-induced TNF-alpha production by reducing the nuclear translocation and DNA binding activity of NF-kappaB. Colforsin 118-127 nuclear factor kappa B subunit 1 Homo sapiens 261-270 12492134-7 2002 An adenylate cyclase activator, forskolin, mimicked the GLP-1-induced increase in [Ca2+]i. Colforsin 32-41 glucagon Rattus norvegicus 56-61 12492134-7 2002 An adenylate cyclase activator, forskolin, mimicked the GLP-1-induced increase in [Ca2+]i. Colforsin 32-41 carbonic anhydrase 2 Rattus norvegicus 83-86 12441059-5 2002 Intra-ACC administration of forskolin rescued behavioral allodynia defective in the AC1&8 DKO mice. Colforsin 28-37 adenylate cyclase 1 Mus musculus 84-87 12376397-8 2002 TNF-alpha also attenuated forskolin-stimulated renin gene expression in primary cultures of mouse JG cells. Colforsin 26-35 tumor necrosis factor Mus musculus 0-9 12372763-5 2002 Selective stimulation of CaMK with Ca(2+) ionophores and of PKA with forskolin or dibutyryl cAMP both result in induction of c-fos mRNA. Colforsin 69-78 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 125-130 12372763-9 2002 Serum, ionomycin, and forskolin all caused a rapid decline in cyclin D1 levels, but only serum effected a subsequent increase, indicative of cell cycle progression. Colforsin 22-31 cyclin D1 Homo sapiens 62-71 12376356-2 2002 Incubation of human bronchi with 10(-6), 3 x 10(-6), and 10(-5) M forskolin (an adenyl cyclase activator) reproduced sensitization to ET-1 and ACh. Colforsin 66-75 endothelin 1 Homo sapiens 134-138 12485839-4 2002 We observed that (1) in the presence of serum, forskolin, an agent known to elevate intracellular cAMP, induced both a morphological change and proliferation of cultured Schwann cells; (2) StAR mRNA and protein were expressed in Schwann cells; (3) unexpectedly, forskolin and 8 Br-cAMP, a cell-permeant analogue of cAMP, extinguishcd StAR gene expression; and (4) this response was similar in the presence or absence of serum. Colforsin 47-56 steroidogenic acute regulatory protein Homo sapiens 189-193 12485839-4 2002 We observed that (1) in the presence of serum, forskolin, an agent known to elevate intracellular cAMP, induced both a morphological change and proliferation of cultured Schwann cells; (2) StAR mRNA and protein were expressed in Schwann cells; (3) unexpectedly, forskolin and 8 Br-cAMP, a cell-permeant analogue of cAMP, extinguishcd StAR gene expression; and (4) this response was similar in the presence or absence of serum. Colforsin 47-56 steroidogenic acute regulatory protein Homo sapiens 334-338 12485839-4 2002 We observed that (1) in the presence of serum, forskolin, an agent known to elevate intracellular cAMP, induced both a morphological change and proliferation of cultured Schwann cells; (2) StAR mRNA and protein were expressed in Schwann cells; (3) unexpectedly, forskolin and 8 Br-cAMP, a cell-permeant analogue of cAMP, extinguishcd StAR gene expression; and (4) this response was similar in the presence or absence of serum. Colforsin 262-271 steroidogenic acute regulatory protein Homo sapiens 189-193 12399414-5 2002 Forskolin, a direct activator of adenylyl cyclase, increased [Ca2+](i) and [Na+](i) via cAMP formation. Colforsin 0-9 cathelicidin antimicrobial peptide Mus musculus 88-92 12399408-5 2002 In the presence of TTX, the adenylate cyclase stimulator, forskolin, increased AVP transcription in the SCN. Colforsin 58-67 arginine vasopressin Rattus norvegicus 79-82 12399414-10 2002 Furthermore, the forskolin-induced increase in GnRH release was blunted in both low Ca2+ and low Na+ media. Colforsin 17-26 gonadotropin releasing hormone 1 Mus musculus 47-51 12397031-8 2002 Glibenclamide, an inhibitor of ATP-sensitive K(+) channels and the cystic fibrosis transmembrane conductance regulator (CFTR), modestly inhibited the forskolin-stimulated current when applied to the apical surface of the monolayers, suggesting a relatively weak effect on CFTR. Colforsin 150-159 CF transmembrane conductance regulator Homo sapiens 67-118 12444902-6 2002 The action of insulin on cyclic nucleotides persisted in the presence of phosphodiesterase inhibition, guanylate cyclase activation by NO donors and adenylate cyclase activation by Iloprost or forskolin. Colforsin 193-202 insulin Homo sapiens 14-21 12453050-5 2002 Furthermore, synaptic facilitation induced by forskolin, an adenylyl cyclase activator, was impaired in R(AB) transgenics and was also rescued by a PP1/2A inhibitor in mutant slices. Colforsin 46-55 protein phosphatase 1 catalytic subunit gamma Mus musculus 148-154 12397031-8 2002 Glibenclamide, an inhibitor of ATP-sensitive K(+) channels and the cystic fibrosis transmembrane conductance regulator (CFTR), modestly inhibited the forskolin-stimulated current when applied to the apical surface of the monolayers, suggesting a relatively weak effect on CFTR. Colforsin 150-159 CF transmembrane conductance regulator Homo sapiens 120-124 12397031-8 2002 Glibenclamide, an inhibitor of ATP-sensitive K(+) channels and the cystic fibrosis transmembrane conductance regulator (CFTR), modestly inhibited the forskolin-stimulated current when applied to the apical surface of the monolayers, suggesting a relatively weak effect on CFTR. Colforsin 150-159 CF transmembrane conductance regulator Homo sapiens 272-276 12417650-9 2002 This selective effect was reproduced by the specific PAC1 agonist maxadilan, as well as by the adenylate cyclase activator forskolin, suggesting that PAC1 provides a potent inhibitory signal for Shh-induced proliferation in developing cerebellum. Colforsin 123-132 sonic hedgehog signaling molecule Rattus norvegicus 195-198 12194985-4 2002 Except for Ser-256 mutants, seven correctly folded AQP2 kinase mutants trafficked as wild-type AQP2 to the apical membrane via forskolin-sensitive intracellular vesicles. Colforsin 127-136 aquaporin 2 Canis lupus familiaris 51-55 12194985-5 2002 With or without forskolin, AQP2-Ser-256A was localized in intracellular vesicles, whereas AQP2-S256D was localized in the apical membrane. Colforsin 16-25 aquaporin 2 Canis lupus familiaris 27-31 12194985-6 2002 Phorbol 12-myristate 13-acetate-induced PKC activation following forskolin treatment resulted in vesicular distribution of all AQP2 kinase mutants, while all were still phosphorylated at Ser-256. Colforsin 65-74 aquaporin 2 Canis lupus familiaris 127-131 12403848-6 2002 The inhibition of forskolin-stimulated cAMP accumulation by DHT was blocked by hydroxyflutamide, a specific inhibitor of the nuclear AR. Colforsin 18-27 androgen receptor Mus musculus 133-135 12186872-3 2002 To understand the mechanism of this induction of the StAR protein, we have examined the effect of Ang II and forskolin, a mimicker of adrenocorticotropic hormone action, on two transcription factors known to modulate StAR gene expression in opposite ways, DAX-1 and SF-1, in bovine adrenal glomerulosa cells in primary culture. Colforsin 109-118 steroidogenic acute regulatory protein Bos taurus 53-57 12391260-7 2002 Two-fold overexpression of AC6 caused enhancement of forskolin-, isoproterenol- and prostaglandin E(2)-stimulated cAMP formation but no changes in basal levels of cAMP. Colforsin 53-62 adenylate cyclase 6 Rattus norvegicus 27-30 12423667-2 2002 Prolonged (24 h) activation of the mu receptor desensitized both mu and ORL1 receptor-mediated inhibition of forskolin-stimulated cAMP accumulation and upregulated GRK2 levels in SH-SY5Y and BE(2)-C cells. Colforsin 109-118 opioid related nociceptin receptor 1 Homo sapiens 72-76 12433376-5 2002 Apoptosis of beta cells can be prevented with intravitreal injections of BDNF+CNTF+forskolin or a caspase inhibitor. Colforsin 83-92 ciliary neurotrophic factor Felis catus 78-82 12391281-8 2002 Finally, semiquantitative reverse transcription-polymerase chain reaction analysis reveals that endogenous A3 AR mRNA is elevated in response to forskolin. Colforsin 145-154 adenosine A3 receptor Mus musculus 107-112 12487379-9 2002 PKA and PKCzeta activators of forskolin and okadaic acid increased catalase activity and 110 kDa expression in NIH3T3 cells up to 2.4-fold and suppressed the cell growth, showing an inverse correlation of the indices (r: -0.9286, r2: 0.8622, n: 18, p < 0.0001). Colforsin 30-39 catalase Mus musculus 67-75 12186872-3 2002 To understand the mechanism of this induction of the StAR protein, we have examined the effect of Ang II and forskolin, a mimicker of adrenocorticotropic hormone action, on two transcription factors known to modulate StAR gene expression in opposite ways, DAX-1 and SF-1, in bovine adrenal glomerulosa cells in primary culture. Colforsin 109-118 steroidogenic acute regulatory protein Bos taurus 217-221 12186872-6 2002 Similarly, forskolin dramatically repressed DAX-1 protein and mRNA expression (to 19.6 +/- 1.8 and 50.3 +/- 4.7% of controls, respectively, p < 0.01). Colforsin 11-20 nuclear receptor subfamily 0 group B member 1 Bos taurus 44-49 12186872-9 2002 Whereas Ang II was without effect on SF-1 expression, forskolin significantly increased SF-1 protein and mRNA levels in a cycloheximide-sensitive manner (to 167.4 +/- 16.6 and 173.1 +/- 25.1% of controls after 6 h, respectively, p < 0.01). Colforsin 54-63 splicing factor 1 Bos taurus 88-92 12145304-2 2002 We found a phosphorylation stoichiometry of 3.0 +/- 0.4 phosphorylated residues/NKCC1 protein harvested from shark rectal gland tubules maximally stimulated with forskolin and calyculin A, showing that at least three sites on the cotransporter are phosphorylated upon stimulation. Colforsin 162-171 solute carrier family 12 member 2 Homo sapiens 80-85 12217874-10 2002 Acute application of PKA agonists (cAMP/forskolin/IBMX) caused a significant increase in UT-A1- and UT-A3-, but not UT-A2-mediated, urea transport. Colforsin 40-49 solute carrier family 14 (urea transporter), member 2 Mus musculus 89-94 12217874-10 2002 Acute application of PKA agonists (cAMP/forskolin/IBMX) caused a significant increase in UT-A1- and UT-A3-, but not UT-A2-mediated, urea transport. Colforsin 40-49 solute carrier family 14 (urea transporter), member 2 Mus musculus 100-105 12114513-3 2002 We now report that a significant elevation of cAMP-response element-binding protein (CREB) occurs in alpha(2)M*-stimulated cells, and this effect is potentiated by isobutylmethylxanthine, dibutyryl-cAMP, or forskolin. Colforsin 207-216 cAMP responsive element binding protein 1 Mus musculus 46-83 12405989-7 2002 Further, activation of the ACVIII promoter by forskolin was potentiated by expression of a constitutively active form of CREB, CREB-VP16, whereas it was inhibited by expression of a dominant-negative form of CREB, A-CREB. Colforsin 46-55 cAMP responsive element binding protein 1 Mus musculus 121-125 12405989-7 2002 Further, activation of the ACVIII promoter by forskolin was potentiated by expression of a constitutively active form of CREB, CREB-VP16, whereas it was inhibited by expression of a dominant-negative form of CREB, A-CREB. Colforsin 46-55 cAMP responsive element binding protein 1 Mus musculus 127-131 12405989-7 2002 Further, activation of the ACVIII promoter by forskolin was potentiated by expression of a constitutively active form of CREB, CREB-VP16, whereas it was inhibited by expression of a dominant-negative form of CREB, A-CREB. Colforsin 46-55 cAMP responsive element binding protein 1 Mus musculus 127-131 12405989-7 2002 Further, activation of the ACVIII promoter by forskolin was potentiated by expression of a constitutively active form of CREB, CREB-VP16, whereas it was inhibited by expression of a dominant-negative form of CREB, A-CREB. Colforsin 46-55 cAMP responsive element binding protein 1 Mus musculus 127-131 12124395-6 2002 In G551D-CFTR cells, channel activity was recovered by co-application of forskolin and genistein in a dose-dependent manner. Colforsin 73-82 CF transmembrane conductance regulator Homo sapiens 9-13 12239104-7 2002 We found that forskolin significantly increased STC gene expression and secretion by both rat and bovine TICs, an effect that was only replicated by human (h) chorionic gonadotropin (CG). Colforsin 14-23 stanniocalcin 1 Homo sapiens 48-51 12239104-7 2002 We found that forskolin significantly increased STC gene expression and secretion by both rat and bovine TICs, an effect that was only replicated by human (h) chorionic gonadotropin (CG). Colforsin 14-23 hypertrichosis 2 (generalised, congenital) Homo sapiens 183-185 12228279-7 2002 CT, LT, dibutyryl-cyclic-3",5"-AMP, and Forskolin also dominantly inhibit interleukin 12 and tumor necrosis factor alpha production by MDDC in the presence of saturating concentrations of lipopolysaccharide. Colforsin 40-49 tumor necrosis factor Homo sapiens 74-120 12369791-10 2002 Functional responses of CD14+ PBMC to KC correlated to forskolin-sensitive cAMP accumulation in cells and were inhibited by protein kinase A inhibitor (PKI) and Rp diastereomer of adenosine 3",5"-cyclic monophosphorothioate. Colforsin 55-64 CD14 molecule Homo sapiens 24-28 12369791-10 2002 Functional responses of CD14+ PBMC to KC correlated to forskolin-sensitive cAMP accumulation in cells and were inhibited by protein kinase A inhibitor (PKI) and Rp diastereomer of adenosine 3",5"-cyclic monophosphorothioate. Colforsin 55-64 calcitonin related polypeptide alpha Homo sapiens 38-40 12235258-8 2002 Norepinephrine-induced ERK1/2 phosphorylation was inhibited by the adenylyl cyclase activator forskolin and was enhanced by the adenylyl cyclase inhibitor 9-(tetrahydro-2-furanyl)-9H-purine-6-amine (SQ 22536) and the protein kinase A inhibitor 4-cyano-3-methylisoquinoline. Colforsin 94-103 mitogen-activated protein kinase 3 Mus musculus 23-29 12351703-2 2002 Activation of the dopamine-D2S receptor inhibited forskolin-induced cAMP production, reduced BayK8644- activated calcium influx, and blocked TRH-mediated p42/p44 MAPK phosphorylation. Colforsin 50-59 thyrotropin releasing hormone Rattus norvegicus 141-144 12351703-2 2002 Activation of the dopamine-D2S receptor inhibited forskolin-induced cAMP production, reduced BayK8644- activated calcium influx, and blocked TRH-mediated p42/p44 MAPK phosphorylation. Colforsin 50-59 mitogen activated protein kinase 3 Rattus norvegicus 158-161 12114513-3 2002 We now report that a significant elevation of cAMP-response element-binding protein (CREB) occurs in alpha(2)M*-stimulated cells, and this effect is potentiated by isobutylmethylxanthine, dibutyryl-cAMP, or forskolin. Colforsin 207-216 cAMP responsive element binding protein 1 Mus musculus 85-89 12114513-3 2002 We now report that a significant elevation of cAMP-response element-binding protein (CREB) occurs in alpha(2)M*-stimulated cells, and this effect is potentiated by isobutylmethylxanthine, dibutyryl-cAMP, or forskolin. Colforsin 207-216 PZP, alpha-2-macroglobulin like Mus musculus 101-110 12082090-7 2002 PP1, an inhibitor of SRC family kinases, blunted both the A(2A)-receptor- and the forskolin-induced MAP kinase stimulation (IC(50) = 50 nm); this was also seen in PC12 cells, which express the A(2A)-receptor endogenously, and in NIH3T3 fibroblasts, in which cAMP causes MAP kinase stimulation. Colforsin 82-91 neuropeptide Y receptor Y4 Rattus norvegicus 0-3 12114502-3 2002 Activation of the cAMP/PKA pathway by forskolin exerted the same effect as that by A(2A)-R stimulation. Colforsin 38-47 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 23-26 12223546-5 2002 The genetic ablation of the AC5 gene eliminated >80% of forskolin-induced AC activity and 85-90% of AC activity stimulated by either D1 or A2A receptor agonists in striatum. Colforsin 59-68 adenylate cyclase 5 Mus musculus 28-31 12082090-7 2002 PP1, an inhibitor of SRC family kinases, blunted both the A(2A)-receptor- and the forskolin-induced MAP kinase stimulation (IC(50) = 50 nm); this was also seen in PC12 cells, which express the A(2A)-receptor endogenously, and in NIH3T3 fibroblasts, in which cAMP causes MAP kinase stimulation. Colforsin 82-91 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 21-24 12175701-8 2002 Treatment of primary cultures of murine embryonic palate mesenchymal (MEPM) cells with forskolin (20 microM) to elevate intracellular cAMP levels, resulted in a time-dependent increase in CREB ser-133 phosphorylation and a corresponding time dependent decrease in PP-1 and PP-2A levels. Colforsin 87-96 cAMP responsive element binding protein 1 Mus musculus 188-192 12082090-8 2002 In the corresponding murine fibroblast cell line SYF, which lacks the ubiquitously expressed SRC family kinases SRC, YES, and FYN, forskolin barely stimulated MAP kinase; this reduction was reversed in cells in which c-SRC had been reintroduced. Colforsin 131-140 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 93-96 12082090-8 2002 In the corresponding murine fibroblast cell line SYF, which lacks the ubiquitously expressed SRC family kinases SRC, YES, and FYN, forskolin barely stimulated MAP kinase; this reduction was reversed in cells in which c-SRC had been reintroduced. Colforsin 131-140 Fyn proto-oncogene Mus musculus 126-129 12175701-8 2002 Treatment of primary cultures of murine embryonic palate mesenchymal (MEPM) cells with forskolin (20 microM) to elevate intracellular cAMP levels, resulted in a time-dependent increase in CREB ser-133 phosphorylation and a corresponding time dependent decrease in PP-1 and PP-2A levels. Colforsin 87-96 protein phosphatase 1 catalytic subunit gamma Mus musculus 264-268 12175701-8 2002 Treatment of primary cultures of murine embryonic palate mesenchymal (MEPM) cells with forskolin (20 microM) to elevate intracellular cAMP levels, resulted in a time-dependent increase in CREB ser-133 phosphorylation and a corresponding time dependent decrease in PP-1 and PP-2A levels. Colforsin 87-96 protein phosphatase 2, regulatory subunit A, alpha Mus musculus 273-278 12393172-3 2002 Using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) reduction assay and a DNA fragmentation assay as indicators of cell survival, we have shown that forskolin confers partial protection against TNF-alpha-mediated cytotoxicity and inhibits TNF-alpha-induced internucleosomal DNA fragmentation in L929 cells. Colforsin 175-184 tumor necrosis factor Mus musculus 220-229 12223234-4 2002 We found that pretreatment of the cells with the selective Raf-1 inhibitor GW5074 (3-(3,5-dibromo-4-hydroxybenzylidene-5-iodo-1,3-dihydro-indol-2-one) (10 microM, 30 min) attenuates chronic deltorphin II-mediated increase in forskolin-stimulated cAMP formation by 40% (n = 6, P < 0.05). Colforsin 225-234 RAF proto-oncogene serine/threonine-protein kinase Cricetulus griseus 59-64 12393172-3 2002 Using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) reduction assay and a DNA fragmentation assay as indicators of cell survival, we have shown that forskolin confers partial protection against TNF-alpha-mediated cytotoxicity and inhibits TNF-alpha-induced internucleosomal DNA fragmentation in L929 cells. Colforsin 175-184 tumor necrosis factor Mus musculus 265-274 12393172-4 2002 The protection conferred by forskolin is cAMP-independent since 1,9-dideoxyforskolin (an adenylate cyclase-inactive analog) also protected against TNF-alpha, while both dibutyryl-cAMP and the cAMP-phosphodiesterase inhibitor theophylline were not protective. Colforsin 28-37 tumor necrosis factor Mus musculus 147-156 12393172-6 2002 We conclude that forskolin acts in a cAMP-independent manner, potentially at a site upstream of caspase-3 activation, to protect against TNF-alpha-mediated cytotoxicity in L929 cells, and that cAMP elevation, in general, does not confer protection against TNF-alpha-induced death in L929 cells. Colforsin 17-26 caspase 3 Mus musculus 96-105 12393172-6 2002 We conclude that forskolin acts in a cAMP-independent manner, potentially at a site upstream of caspase-3 activation, to protect against TNF-alpha-mediated cytotoxicity in L929 cells, and that cAMP elevation, in general, does not confer protection against TNF-alpha-induced death in L929 cells. Colforsin 17-26 tumor necrosis factor Mus musculus 137-146 12393172-6 2002 We conclude that forskolin acts in a cAMP-independent manner, potentially at a site upstream of caspase-3 activation, to protect against TNF-alpha-mediated cytotoxicity in L929 cells, and that cAMP elevation, in general, does not confer protection against TNF-alpha-induced death in L929 cells. Colforsin 17-26 tumor necrosis factor Mus musculus 256-265 12205148-3 2002 L-LTP can be induced by either multiple-train tetanization, NO or 8-Br-cGMP paired with one-train tetanization, or the cAMP activator forskolin, and all three types of potentiation are accompanied by an increase in phospho-CREB immunofluorescence in the CA1 cell body area. Colforsin 134-143 liver transport protein Mus musculus 2-5 12211438-5 2002 These acute effects of PTH(1-34) were mimicked by PKA stimulators (8-bromoadenosine [8Br]-cAMP or forskolin [FSK]), blocked by the PKA inhibitor Rp-cAMPs but unaffected by the PKC inhibitor GF109203X. Colforsin 98-107 parathyroid hormone Mus musculus 23-26 12211438-5 2002 These acute effects of PTH(1-34) were mimicked by PKA stimulators (8-bromoadenosine [8Br]-cAMP or forskolin [FSK]), blocked by the PKA inhibitor Rp-cAMPs but unaffected by the PKC inhibitor GF109203X. Colforsin 109-112 parathyroid hormone Mus musculus 23-26 12358756-5 2002 Long-term 18 h treatment with the D2 receptor agonist, quinpirole, resulted in a two-fold enhancement of forskolin-stimulated cyclic AMP accumulation. Colforsin 105-114 dopamine receptor D2 Mus musculus 34-45 12354282-7 2002 Significantly, tyramine reduces forskolin-stimulated cAMP levels in HEK293 cells stably expressing SER-2 with an IC50 of about 360 nm, suggesting that SER-2 is a tyramine receptor. Colforsin 32-41 jagged canonical Notch ligand 2 Homo sapiens 99-104 12354282-7 2002 Significantly, tyramine reduces forskolin-stimulated cAMP levels in HEK293 cells stably expressing SER-2 with an IC50 of about 360 nm, suggesting that SER-2 is a tyramine receptor. Colforsin 32-41 jagged canonical Notch ligand 2 Homo sapiens 151-156 12181425-3 2002 Injections of rats with dibutyryl cAMP (dbcAMP) or forskolin increased both PDE3 and PDE4 activities in aortic and femoral artery VSMC. Colforsin 51-60 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 76-80 12181425-7 2002 Consistent with the effect of increased VSMC cAMP PDE on blood vessel function, inhibition of PDE3 and PDE4 activities potentiated the relaxant effect of forskolin in dbcAMP-treated femoral artery rings to a greater extent than in untreated control blood vessels. Colforsin 154-163 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 94-98 12243774-0 2002 Modulation of voltage-gated K(+) channels Kv11 and Kv1 4 by forskolin. Colforsin 60-69 potassium voltage-gated channel subfamily A member 1 Homo sapiens 42-46 12243774-3 2002 Low FSK concentrations induced a phosphorylation-dependent potentiation of Kv1.1 currents. Colforsin 4-7 potassium voltage-gated channel subfamily A member 1 Homo sapiens 75-80 12243774-5 2002 Kv1.4 currents were inhibited with lower potency by FSK but were not modified by phosphorylation. Colforsin 52-55 potassium voltage-gated channel subfamily A member 4 Homo sapiens 0-5 12147269-4 2002 However, forskolin induces cAMP production and ablates TGF beta-stimulated increases in CTGF mRNA. Colforsin 9-18 transforming growth factor, beta 1 Rattus norvegicus 55-63 12065583-6 2002 In Chinese hamster ovary cells transiently expressing TG1019, the forskolin-stimulated production of cAMP was inhibited up to approximately 70% by 5-oxo-ETE, with an IC(50) value of 33 nM. Colforsin 66-75 oxoeicosanoid receptor 1 Homo sapiens 54-60 12050161-11 2002 Artificial elevation of cAMP with forskolin activated ERK and caused a partial induction of c-Fos. Colforsin 34-43 mitogen-activated protein kinase 1 Mus musculus 54-57 12050161-11 2002 Artificial elevation of cAMP with forskolin activated ERK and caused a partial induction of c-Fos. Colforsin 34-43 FBJ osteosarcoma oncogene Mus musculus 92-97 12050161-12 2002 Finally, treatment of G alpha(q) (Q209L)-infected cells with forskolin enhanced the induction of c-Fos showing that the two pathways are independent and additive. Colforsin 61-70 FBJ osteosarcoma oncogene Mus musculus 97-102 12147269-4 2002 However, forskolin induces cAMP production and ablates TGF beta-stimulated increases in CTGF mRNA. Colforsin 9-18 cellular communication network factor 2 Rattus norvegicus 88-92 12147269-5 2002 A similar pattern of CTGF expression in response to PGE(2) and forskolin is observed in neonatal rat primary smooth muscle cell cultures. Colforsin 63-72 cellular communication network factor 2 Rattus norvegicus 21-25 12163474-5 2002 In MAP2-deficient cultured neurons, the induction rate of phosphorylated CREB after forskolin stimulation was much lower than in wild-type neurons. Colforsin 84-93 cAMP responsive element binding protein 1 Mus musculus 73-77 12146978-8 2002 In addition, cholera toxin, forskolin, and 8BrcAMP all mimic ACTH, causing dephosphorylation of Akt/PKB in wild-type Y1 cells. Colforsin 28-37 pro-opiomelanocortin-alpha Mus musculus 61-65 12146978-8 2002 In addition, cholera toxin, forskolin, and 8BrcAMP all mimic ACTH, causing dephosphorylation of Akt/PKB in wild-type Y1 cells. Colforsin 28-37 thymoma viral proto-oncogene 1 Mus musculus 96-103 12181283-11 2002 The application of dbcAMP and forskolin in combination with NPY negated the effect of NPY alone. Colforsin 30-39 neuropeptide Y Mus musculus 86-89 12130558-8 2002 Forskolin treatment stimulated the expression of cyclin D2 mRNA in control granulosa cells, whereas DHT treatment abolished this response. Colforsin 0-9 cyclin D2 Rattus norvegicus 49-58 12147288-10 2002 Furthermore, cells overexpressing the mutant receptor became responsive to I-BOP-induced Ca2+ mobilization even after pretreatment with PGE1 or forskolin. Colforsin 144-153 BOP Homo sapiens 77-80 12193136-5 2002 Forskolin, a potent stimulator which stimulates adenylate cyclase and increases the intracellular cAMP level, partially inhibited insulin-stimulated glucose uptake in 3T3-L1 cells, but had no significant impact on the effect of ET-1. Colforsin 0-9 endothelin 1 Mus musculus 228-232 12130572-2 2002 Two N-terminal peptides, ANXA1(Ac2-26) and ANXA1(Ac1-50), inhibited forskolin-evoked ACTH and prolactin release; however, they lacked the potency and full efficacy of the parent molecule (ANXA1(1-346)), whereas other shorter N-terminal sequences were without effect. Colforsin 68-77 annexin A1 Homo sapiens 25-30 12450317-6 2002 Forskolin-induced increase in E2 and P4 production was attenuated by CRH. Colforsin 0-9 cystatin 12, pseudogene Homo sapiens 30-39 12130572-2 2002 Two N-terminal peptides, ANXA1(Ac2-26) and ANXA1(Ac1-50), inhibited forskolin-evoked ACTH and prolactin release; however, they lacked the potency and full efficacy of the parent molecule (ANXA1(1-346)), whereas other shorter N-terminal sequences were without effect. Colforsin 68-77 adenylate cyclase 2 Homo sapiens 31-34 12130572-2 2002 Two N-terminal peptides, ANXA1(Ac2-26) and ANXA1(Ac1-50), inhibited forskolin-evoked ACTH and prolactin release; however, they lacked the potency and full efficacy of the parent molecule (ANXA1(1-346)), whereas other shorter N-terminal sequences were without effect. Colforsin 68-77 annexin A1 Homo sapiens 43-48 12130572-2 2002 Two N-terminal peptides, ANXA1(Ac2-26) and ANXA1(Ac1-50), inhibited forskolin-evoked ACTH and prolactin release; however, they lacked the potency and full efficacy of the parent molecule (ANXA1(1-346)), whereas other shorter N-terminal sequences were without effect. Colforsin 68-77 long intergenic non-protein coding RNA 1587 Homo sapiens 49-52 12130572-2 2002 Two N-terminal peptides, ANXA1(Ac2-26) and ANXA1(Ac1-50), inhibited forskolin-evoked ACTH and prolactin release; however, they lacked the potency and full efficacy of the parent molecule (ANXA1(1-346)), whereas other shorter N-terminal sequences were without effect. Colforsin 68-77 proopiomelanocortin Homo sapiens 85-89 12130572-2 2002 Two N-terminal peptides, ANXA1(Ac2-26) and ANXA1(Ac1-50), inhibited forskolin-evoked ACTH and prolactin release; however, they lacked the potency and full efficacy of the parent molecule (ANXA1(1-346)), whereas other shorter N-terminal sequences were without effect. Colforsin 68-77 annexin A1 Homo sapiens 43-48 12450317-6 2002 Forskolin-induced increase in E2 and P4 production was attenuated by CRH. Colforsin 0-9 corticotropin releasing hormone Homo sapiens 69-72 12127049-7 2002 Furthermore, while total cellular and cell surface CXCR4 protein levels were up-regulated in human PBL and in Jurkat T cells in response to DcAMP or forskolin stimulation, CXCR4 levels were unchanged by stimulation in CEM cells. Colforsin 149-158 C-X-C motif chemokine receptor 4 Homo sapiens 51-56 12145806-5 2002 RESULTS: Total anion secretion stimulated by forskolin treatment of NKCC1-null duodenum resulted from approximately equivalent rates of electrogenic chloride, electrogenic bicarbonate, and electroneutral bicarbonate secretion. Colforsin 45-54 solute carrier family 12, member 2 Mus musculus 68-73 12182941-2 2002 Regulation of the cell content of alpha-MSH and beta-endorphin occurred in two phases consisting of (a) initial depletion of cellular levels of these peptide hormones during short-term secretion (3 h) induced by isoproterenol, forskolin, or phorbol myristate acetate (PMA) which was followed by (b) long-term (24 h) increases in cellular levels of alpha-MSH and beta-endorphin in response to stimulated secretion induced by isoproterenol and PMA. Colforsin 227-236 proopiomelanocortin Homo sapiens 34-43 12177237-8 2002 CFTR functionality was assessed by analyzing the Cl(-) secretion after amiloride and forskolin perfusion. Colforsin 85-94 CF transmembrane conductance regulator Homo sapiens 0-4 12181609-2 2002 In wild-type CHO cells, after exposure to 2.5 microM forskolin, 25 microM genistein induced a further 2-fold and rapid increase of the forskolin-activated CFTR current. Colforsin 53-62 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 155-159 12181609-2 2002 In wild-type CHO cells, after exposure to 2.5 microM forskolin, 25 microM genistein induced a further 2-fold and rapid increase of the forskolin-activated CFTR current. Colforsin 135-144 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 155-159 12182941-2 2002 Regulation of the cell content of alpha-MSH and beta-endorphin occurred in two phases consisting of (a) initial depletion of cellular levels of these peptide hormones during short-term secretion (3 h) induced by isoproterenol, forskolin, or phorbol myristate acetate (PMA) which was followed by (b) long-term (24 h) increases in cellular levels of alpha-MSH and beta-endorphin in response to stimulated secretion induced by isoproterenol and PMA. Colforsin 227-236 proopiomelanocortin Homo sapiens 48-62 12182941-3 2002 In short-term experiments (3 h), cellular levels of alpha-MSH and beta-endorphin were reduced by 30-50% during stimulated secretion of these peptide hormones by isoproterenol (agonist for the beta-adrenergic receptor), forskolin that activates protein kinase A (PKA), and PMA that activates protein kinase C (PKC). Colforsin 219-228 proopiomelanocortin Homo sapiens 52-61 12182941-3 2002 In short-term experiments (3 h), cellular levels of alpha-MSH and beta-endorphin were reduced by 30-50% during stimulated secretion of these peptide hormones by isoproterenol (agonist for the beta-adrenergic receptor), forskolin that activates protein kinase A (PKA), and PMA that activates protein kinase C (PKC). Colforsin 219-228 proopiomelanocortin Homo sapiens 66-80 12084577-3 2002 The role of cis-acting elements within the CFTR minimal promoter in modulating responses to phorbol 12-myristate 13-acetate (PMA) and forskolin was assessed using luciferase reporter gene (luc)-containing plasmids transfected into Calu-3 and HT-29 cells. Colforsin 134-143 CF transmembrane conductance regulator Homo sapiens 43-47 12095540-0 2002 Activation of CFTR Cl(-) channel by tyrphostins via a protein tyrosine kinase-independent pathway in forskolin-stimulated renal epithelial A6 cells. Colforsin 101-110 CF transmembrane conductance regulator Homo sapiens 14-18 12095540-1 2002 We studied effects of tyrphostin A23 (an inhibitor of protein tyrosine kinase; PTK) and tyrphostin A63 (an inactive analog of tyrphostin A23) on forskolin-activated cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and Cl(-) secretion in renal epithelial A6 cells. Colforsin 145-154 CF transmembrane conductance regulator Homo sapiens 165-216 12095540-3 2002 However, under the forskolin-stimulated condition, tyrphostin A23 and A63 stimulated Cl(-) secretion by activating CFTR Cl(-) channels. Colforsin 19-28 CF transmembrane conductance regulator Homo sapiens 115-119 12084577-10 2002 As expected, endogenous CFTR expression increased in response to forskolin and decreased in response to PMA. Colforsin 65-74 CF transmembrane conductance regulator Homo sapiens 24-28 12151779-3 2002 To test this hypothesis, we used rat hypothalamic fragments and immortalized gonadotropin-releasing hormone neurons (GT1-7) in vitro and examined whether orphanin FQ would inhibit forskolin-induced gonadotropin-releasing hormone release. Colforsin 180-189 prepronociceptin Rattus norvegicus 154-165 12106667-12 2002 ORL(1) transcript levels did not significantly change, but vasoactive intestinal polypeptide (VIP) transcripts exhibited substantial increases, in the presence of forskolin or CTX. Colforsin 163-172 vasoactive intestinal peptide Homo sapiens 59-92 12106667-12 2002 ORL(1) transcript levels did not significantly change, but vasoactive intestinal polypeptide (VIP) transcripts exhibited substantial increases, in the presence of forskolin or CTX. Colforsin 163-172 vasoactive intestinal peptide Homo sapiens 94-97 12151779-4 2002 The studies revealed that orphanin FQ potently and dose-dependently inhibits forskolin-induced gonadotropin-releasing hormone release from rat hypothalamic fragments. Colforsin 77-86 prepronociceptin Rattus norvegicus 26-37 12111799-6 2002 On the contrary, forskolin and dibutyryl cAMP, which elevate intracellular cAMP by independent mechanisms, both counteracted H(2)O(2)-induced Fas, but not FasL, mRNA upregulation and increased constitutive expression of FasL mRNA. Colforsin 17-26 Fas ligand Rattus norvegicus 220-224 12006579-6 2002 Wild-type MEFs were responsive to S1P in activation of Rho and phospholipase C (PLC), intracellular calcium mobilization, and inhibition of forskolin-activated adenylyl cyclase. Colforsin 140-149 sphingosine-1-phosphate receptor 1 Mus musculus 34-37 12117553-4 2002 Western blotting showed that incubation of GH3 cells with forskolin, which enhances CART mRNA expression, caused an increase in phosphorylated CREB (P-CREB) levels. Colforsin 58-67 CART prepropeptide Rattus norvegicus 84-88 12117553-4 2002 Western blotting showed that incubation of GH3 cells with forskolin, which enhances CART mRNA expression, caused an increase in phosphorylated CREB (P-CREB) levels. Colforsin 58-67 cAMP responsive element binding protein 1 Rattus norvegicus 143-147 12117553-4 2002 Western blotting showed that incubation of GH3 cells with forskolin, which enhances CART mRNA expression, caused an increase in phosphorylated CREB (P-CREB) levels. Colforsin 58-67 cAMP responsive element binding protein 1 Rattus norvegicus 151-155 11978789-3 2002 The prosurvival effects of GLP-2 on LY294002-induced cell death were independent of Akt, p90(Rsk), or p70 S6 kinase activation; were mimicked by forskolin; and were abrogated by inhibition of protein kinase A (PKA) activity. Colforsin 145-154 mast cell protease 10 Rattus norvegicus 27-32 12126964-7 2002 These results suggest that angiotensin II down-regulates AT(1)-mRNA level of rat cardiomyocytes by inhibiting the transcription of AT(1) gene, which is mediated by AT(1) receptor and related to the activation of protein kinase C. Stimulation by forskolin plus 3-isobutyl-1-methyl-xanthine (IBMX) decreased the expression of AT(1)-mRNA to 68.1 +/- 21.5% of control at 6 h treatment; while increased to 207.9 +/- 27.1% of control at 48 h treatment. Colforsin 245-254 angiotensin II receptor, type 1a Rattus norvegicus 131-136 12126964-11 2002 The cAMP responsible element (CRE) cis-element located in the region -201/-61 of rat AT(1A) promoter is forskolin inducible, which may mediate the up-regulation of AT(1)-mRNA expression induced by cAMP long-lasting stimulation. Colforsin 104-113 angiotensin II receptor, type 1a Rattus norvegicus 85-90 12126964-7 2002 These results suggest that angiotensin II down-regulates AT(1)-mRNA level of rat cardiomyocytes by inhibiting the transcription of AT(1) gene, which is mediated by AT(1) receptor and related to the activation of protein kinase C. Stimulation by forskolin plus 3-isobutyl-1-methyl-xanthine (IBMX) decreased the expression of AT(1)-mRNA to 68.1 +/- 21.5% of control at 6 h treatment; while increased to 207.9 +/- 27.1% of control at 48 h treatment. Colforsin 245-254 angiotensinogen Rattus norvegicus 27-41 12126964-11 2002 The cAMP responsible element (CRE) cis-element located in the region -201/-61 of rat AT(1A) promoter is forskolin inducible, which may mediate the up-regulation of AT(1)-mRNA expression induced by cAMP long-lasting stimulation. Colforsin 104-113 angiotensin II receptor, type 1a Rattus norvegicus 164-169 12126964-7 2002 These results suggest that angiotensin II down-regulates AT(1)-mRNA level of rat cardiomyocytes by inhibiting the transcription of AT(1) gene, which is mediated by AT(1) receptor and related to the activation of protein kinase C. Stimulation by forskolin plus 3-isobutyl-1-methyl-xanthine (IBMX) decreased the expression of AT(1)-mRNA to 68.1 +/- 21.5% of control at 6 h treatment; while increased to 207.9 +/- 27.1% of control at 48 h treatment. Colforsin 245-254 angiotensin II receptor, type 1a Rattus norvegicus 57-62 12126964-7 2002 These results suggest that angiotensin II down-regulates AT(1)-mRNA level of rat cardiomyocytes by inhibiting the transcription of AT(1) gene, which is mediated by AT(1) receptor and related to the activation of protein kinase C. Stimulation by forskolin plus 3-isobutyl-1-methyl-xanthine (IBMX) decreased the expression of AT(1)-mRNA to 68.1 +/- 21.5% of control at 6 h treatment; while increased to 207.9 +/- 27.1% of control at 48 h treatment. Colforsin 245-254 angiotensin II receptor, type 1a Rattus norvegicus 131-136 12055093-4 2002 Insulin-stimulated leptin secretion could also be inhibited by a series of agents increasing intracellular cAMP levels, such as lipolytic hormones (ACTH and thyrotropin-stimulating hormone), various nonhydrolyzable cAMP analogs, pertussis toxin, forskolin, methylxanthines (caffeine, theophylline, IBMX), and specific inhibitors of phosphodiesterase III (imazodan, milrinone, and amrinone). Colforsin 246-255 leptin Rattus norvegicus 19-25 12126964-7 2002 These results suggest that angiotensin II down-regulates AT(1)-mRNA level of rat cardiomyocytes by inhibiting the transcription of AT(1) gene, which is mediated by AT(1) receptor and related to the activation of protein kinase C. Stimulation by forskolin plus 3-isobutyl-1-methyl-xanthine (IBMX) decreased the expression of AT(1)-mRNA to 68.1 +/- 21.5% of control at 6 h treatment; while increased to 207.9 +/- 27.1% of control at 48 h treatment. Colforsin 245-254 angiotensin II receptor, type 1a Rattus norvegicus 131-136 12086962-8 2002 Third, exogenous addition of dibutyryl cAMP, endogenous stimulation of cAMP production by forskolin, and antioxidant N-acetylcysteine (NAC) prevented stimulation of TNF-alpha secretion caused by AA alone or with high glucose. Colforsin 90-99 tumor necrosis factor Homo sapiens 165-174 12111350-11 2002 8-Br-cAMP and forskolin also increased PDE4 activity. Colforsin 14-23 phosphodiesterase 4A Homo sapiens 39-43 12093828-5 2002 Insulin-like growth factor-binding protein-1, a marker of decidualization, was clearly induced by db-cAMP, forskolin or E(2) + MPA, accompanied by morphological changes characteristic of decidualization. Colforsin 107-116 insulin like growth factor binding protein 1 Homo sapiens 0-44 12107264-7 2002 However, the intracellular level of connexin 43 was elevated in the presence of LH, forskolin, and Dex. Colforsin 84-93 gap junction protein alpha 1 Homo sapiens 36-47 12110442-8 2002 Treatment of cells with H-89, a PKA inhibitor, significantly reduced the ability of PTH and FSK to induce RANKL and inhibit OPG mRNA expression. Colforsin 92-95 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 106-111 12110442-8 2002 Treatment of cells with H-89, a PKA inhibitor, significantly reduced the ability of PTH and FSK to induce RANKL and inhibit OPG mRNA expression. Colforsin 92-95 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 124-127 12107264-8 2002 Endogenous levels of the survival gene protein Bcl-2 were significantly elevated in all cultures treated with Dex compared with either nonstimulated cultures or cultures stimulated with LH and forskolin. Colforsin 193-202 BCL2 apoptosis regulator Homo sapiens 47-52 12184734-4 2002 The attenuation of forskolin-stimulated cAMP formation by the stimulation of hm2 receptors was reduced in a medium containing toluene. Colforsin 19-28 cholinergic receptor muscarinic 2 Homo sapiens 77-80 12107239-1 2002 A dose- and time-dependent increase in the human GnRH receptor (GnRHR) promoter activity after forskolin treatment was observed after transient transfection of human placental choriocarcinoma JEG-3 cells with a 2297-bp human GnRHR promoter-luciferase construct (p2300-LucF). Colforsin 95-104 gonadotropin releasing hormone receptor Homo sapiens 49-62 12107239-1 2002 A dose- and time-dependent increase in the human GnRH receptor (GnRHR) promoter activity after forskolin treatment was observed after transient transfection of human placental choriocarcinoma JEG-3 cells with a 2297-bp human GnRHR promoter-luciferase construct (p2300-LucF). Colforsin 95-104 gonadotropin releasing hormone receptor Homo sapiens 64-69 12107239-1 2002 A dose- and time-dependent increase in the human GnRH receptor (GnRHR) promoter activity after forskolin treatment was observed after transient transfection of human placental choriocarcinoma JEG-3 cells with a 2297-bp human GnRHR promoter-luciferase construct (p2300-LucF). Colforsin 95-104 gonadotropin releasing hormone receptor Homo sapiens 225-230 12107239-3 2002 A specific adenylate cyclase inhibitor or protein kinase A inhibitor pretreatment reversed the forskolin- and human chorionic gonadotropin-induced increase in the human GnRHR promoter activity. Colforsin 95-104 gonadotropin releasing hormone receptor Homo sapiens 169-174 12107239-6 2002 Mutation of the putative hGR-AP/CRE-1 and hGR-AP/CRE-2 resulted in 32% and 35% decreases in the forskolin-induced stimulation, respectively. Colforsin 96-105 GRB2 related adaptor protein Homo sapiens 25-31 12107239-6 2002 Mutation of the putative hGR-AP/CRE-1 and hGR-AP/CRE-2 resulted in 32% and 35% decreases in the forskolin-induced stimulation, respectively. Colforsin 96-105 GRB2 related adaptor protein Homo sapiens 42-48 12099721-4 2002 A pro-apoptotic effect of beta(1)-AR was also blocked by the PKA inhibitor H89, while the protein kinase A (PKA) activators forskolin and dibutyryl-cAMP both induced apoptosis. Colforsin 124-133 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 90-106 12099721-4 2002 A pro-apoptotic effect of beta(1)-AR was also blocked by the PKA inhibitor H89, while the protein kinase A (PKA) activators forskolin and dibutyryl-cAMP both induced apoptosis. Colforsin 124-133 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 108-111 12065707-3 2002 Forskolin/IBMX treatment completely dephosphorylated a selective protein phosphatase 2A (PP2A) substrate, elongation factor-2 (EF-2), at its Ca(2+) calmodulin-dependent kinase site, and decreased phosphorylation of substrates for cyclin-dependent kinases, including retinoblastoma (Rb) protein. Colforsin 0-9 eukaryotic translation elongation factor 2 Rattus norvegicus 106-125 12065707-3 2002 Forskolin/IBMX treatment completely dephosphorylated a selective protein phosphatase 2A (PP2A) substrate, elongation factor-2 (EF-2), at its Ca(2+) calmodulin-dependent kinase site, and decreased phosphorylation of substrates for cyclin-dependent kinases, including retinoblastoma (Rb) protein. Colforsin 0-9 eukaryotic translation elongation factor 2 Rattus norvegicus 127-131 12184734-9 2002 On the contrary of the effect of toluene for [35S]GTPgammaS binding, the effect of toluene for attenuation of forskolin-stimulated cAMP formation by the stimulation of hm2 receptors was irreversible. Colforsin 110-119 cholinergic receptor muscarinic 2 Homo sapiens 168-171 12077213-3 2002 Striatal slices from PDE1B(-/-) mice exhibited increased levels of phospho-Thr34 DARPP-32 and phospho-Ser845 GluR1 after dopamine D1 receptor agonist or forskolin stimulation. Colforsin 153-162 phosphodiesterase 1B, Ca2+-calmodulin dependent Mus musculus 21-26 12137745-3 2002 Recently, we demonstrated that NEP/CD10 is upregulated during forskolin-induced choriocarcinoma cell differentiation, suggesting that NEP/CD10 is a trophoblast differentiation marker. Colforsin 62-71 membrane metalloendopeptidase Homo sapiens 31-34 12137745-3 2002 Recently, we demonstrated that NEP/CD10 is upregulated during forskolin-induced choriocarcinoma cell differentiation, suggesting that NEP/CD10 is a trophoblast differentiation marker. Colforsin 62-71 membrane metalloendopeptidase Homo sapiens 35-39 12137745-3 2002 Recently, we demonstrated that NEP/CD10 is upregulated during forskolin-induced choriocarcinoma cell differentiation, suggesting that NEP/CD10 is a trophoblast differentiation marker. Colforsin 62-71 membrane metalloendopeptidase Homo sapiens 134-137 12137745-3 2002 Recently, we demonstrated that NEP/CD10 is upregulated during forskolin-induced choriocarcinoma cell differentiation, suggesting that NEP/CD10 is a trophoblast differentiation marker. Colforsin 62-71 membrane metalloendopeptidase Homo sapiens 138-142 11943777-6 2002 Treatment of cells with forskolin results in a robust enhancement of the DNA binding of Arix, which is reversed by treatment with serine/threonine and tyrosine phosphatase inhibitors. Colforsin 24-33 paired like homeobox 2A Homo sapiens 88-92 11943777-7 2002 Consistent with the DNA binding activity of Arix, treatment of cultured cells with phosphatase inhibitors diminishes transcriptional activation with Arix plus forskolin. Colforsin 159-168 paired like homeobox 2A Homo sapiens 44-48 12056823-0 2002 Secretion of MUC5AC mucin from pancreatic cancer cells in response to forskolin and VIP. Colforsin 70-79 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 13-19 12056823-3 2002 In this study, we demonstrate that stimulation of adenylyl cyclase and the protein kinase A (PKA) pathway by forskolin and vasoactive intestinal peptide (VIP) increased MUC5AC antigen expression and release from pancreatic cancer cells. Colforsin 109-118 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 169-175 11997316-4 2002 Furthermore, by using a fracture-label technique applied to LLC-PK(1) cells expressing an AQP2-c-myc construct, we show that AQP2 is located in IMP aggregates and is concentrated in shallow membrane invaginations on the surface of forskolin-stimulated cells. Colforsin 231-240 aquaporin 2 Homo sapiens 125-129 12062899-4 2002 Acute melatonin treatment of INS-1 cells in the presence of either forskolin or the incretin hormone glucagon-like peptide 1 (GLP-1) caused an attenuation of the responses in insulin secretion, insulin promoter activity, and CRE mediated gene expression, consistent with its effects in inhibiting cAMP mediated signal transduction. Colforsin 67-76 insulin 1 Rattus norvegicus 29-34 12062899-5 2002 However, prolonged exposure (12 h) of INS-1 cells to melatonin treatment resulted in a sensitization of cAMP mediated responses to forskolin and GLP-1. Colforsin 131-140 insulin 1 Rattus norvegicus 38-43 11997240-4 2002 HS and cAMP-elevating drugs (forskolin and dibutyryl cAMP-acetoxymethyl ester) similarly suppressed extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase activation and superoxide formation in response to N-formylmethionyl-leucyl-phenylalanine (fMLP) stimulation. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 100-137 11997240-4 2002 HS and cAMP-elevating drugs (forskolin and dibutyryl cAMP-acetoxymethyl ester) similarly suppressed extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase activation and superoxide formation in response to N-formylmethionyl-leucyl-phenylalanine (fMLP) stimulation. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 139-142 11997240-4 2002 HS and cAMP-elevating drugs (forskolin and dibutyryl cAMP-acetoxymethyl ester) similarly suppressed extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase activation and superoxide formation in response to N-formylmethionyl-leucyl-phenylalanine (fMLP) stimulation. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 148-151 12034881-7 2002 In cultures of polarized human thyrocytes from normal patients, thyroid-stimulating hormone or forskolin increased, to a similar extent, Rab5a and Rab7 but not Rab8 expression, apical endocytosis of thyroglobulin and lucifer yellow, and basolateral secretion of T(3) and T(4). Colforsin 95-104 RAB5A, member RAS oncogene family Homo sapiens 137-142 12034881-7 2002 In cultures of polarized human thyrocytes from normal patients, thyroid-stimulating hormone or forskolin increased, to a similar extent, Rab5a and Rab7 but not Rab8 expression, apical endocytosis of thyroglobulin and lucifer yellow, and basolateral secretion of T(3) and T(4). Colforsin 95-104 RAB7B, member RAS oncogene family Homo sapiens 147-151 12034881-7 2002 In cultures of polarized human thyrocytes from normal patients, thyroid-stimulating hormone or forskolin increased, to a similar extent, Rab5a and Rab7 but not Rab8 expression, apical endocytosis of thyroglobulin and lucifer yellow, and basolateral secretion of T(3) and T(4). Colforsin 95-104 RAB8A, member RAS oncogene family Homo sapiens 160-164 12070611-11 2002 Treating seabream embryos with forskolin, a protein kinase A activator, inhibited MyoD1 expression in adaxial cells, while expression in fast muscle precursors was not affected. Colforsin 31-40 myogenic differentiation 1 Danio rerio 82-87 12114266-9 2002 We further provide evidence that CRH signaling can be mimicked by activation of cAMP/PKA/CREB using forskolin in primary human microvascular endothelial cells. Colforsin 100-109 corticotropin releasing hormone Homo sapiens 33-36 12114266-9 2002 We further provide evidence that CRH signaling can be mimicked by activation of cAMP/PKA/CREB using forskolin in primary human microvascular endothelial cells. Colforsin 100-109 cAMP responsive element binding protein 1 Homo sapiens 89-93 12093484-8 2002 At this concentration, NPY (and NPY 18-36) was able to inhibit forskolin (FSK)-induced cyclic adenosine-5"-monophosphate (cAMP) elevation in rat left ventricle slices. Colforsin 63-72 neuropeptide Y Rattus norvegicus 23-26 12093484-8 2002 At this concentration, NPY (and NPY 18-36) was able to inhibit forskolin (FSK)-induced cyclic adenosine-5"-monophosphate (cAMP) elevation in rat left ventricle slices. Colforsin 63-72 neuropeptide Y Rattus norvegicus 32-35 12093484-8 2002 At this concentration, NPY (and NPY 18-36) was able to inhibit forskolin (FSK)-induced cyclic adenosine-5"-monophosphate (cAMP) elevation in rat left ventricle slices. Colforsin 74-77 neuropeptide Y Rattus norvegicus 23-26 12093484-8 2002 At this concentration, NPY (and NPY 18-36) was able to inhibit forskolin (FSK)-induced cyclic adenosine-5"-monophosphate (cAMP) elevation in rat left ventricle slices. Colforsin 74-77 neuropeptide Y Rattus norvegicus 32-35 12095941-12 2002 Furthermore, E1 induced a twofold increase in connexin 43 (Cx43), whereas forskolin caused a 50% reduction in Cx32 expression in RWPE-1 cells. Colforsin 74-83 gap junction protein beta 1 Homo sapiens 110-114 12095946-5 2002 In addition, both forskolin and estrone increase Cx43 expression levels in WPEI-10 cells, with no apparent effect on WPEI-7 cells. Colforsin 18-27 gap junction protein alpha 1 Homo sapiens 49-53 12095946-6 2002 Conversely, forskolin and especially estrone induce a marked increase of Cx32 in WPEI-7 cells, whereas Cx32 expression is limitedly affected by both agents in WPEI-10 cells. Colforsin 12-21 gap junction protein beta 1 Homo sapiens 73-77 12021185-5 2002 Iodide accumulation increased after 2-h exposure to 5 IU/ml hCG, to 6-fold over the basal level after 8 h. This effect was reproduced using forskolin, the cAMP analog (Bu)(2)-cAMP, and phorbol acetate. Colforsin 140-149 chorionic gonadotropin subunit beta 5 Homo sapiens 60-63 12040081-8 2002 The forskolin-induced current potentiation was greatly reduced in cells transfected with VR-1 mutants carrying point mutations at the predicted PKA phosphorylation sites. Colforsin 4-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-93 12021190-9 2002 Treatment with FSH (0.9 IU/ml) or forskolin for 20 min increased CREB phosphorylation, but had little effect on AKT phosphorylation. Colforsin 34-43 cAMP responsive element binding protein 1 Rattus norvegicus 65-69 12050262-12 2002 Treatment of human thecal cells with GDF-9 blocked forskolin-stimulated progesterone, 17alpha-hydroxyprogesterone, and dehydroepiandrosterone synthesis. Colforsin 51-60 growth differentiation factor 9 Homo sapiens 37-42 12135537-6 2002 5-HT1A-mediated inhibition of forskolin-stimulated adenylyl cyclase (AC) was taken as an index of 5-HT1A receptor activation. Colforsin 30-39 5-hydroxytryptamine receptor 1A Homo sapiens 0-6 12135537-6 2002 5-HT1A-mediated inhibition of forskolin-stimulated adenylyl cyclase (AC) was taken as an index of 5-HT1A receptor activation. Colforsin 30-39 5-hydroxytryptamine receptor 1A Homo sapiens 98-113 12097191-4 2002 Agonists increased [(35)S]GTP gamma S binding or inhibited forskolin-stimulated cAMP, presumably by coupling to G(i/o), in cells expressing hCB(1) but not hCB(1)-G(alpha 16). Colforsin 59-68 cannabinoid receptor 1 Homo sapiens 140-146 12097191-4 2002 Agonists increased [(35)S]GTP gamma S binding or inhibited forskolin-stimulated cAMP, presumably by coupling to G(i/o), in cells expressing hCB(1) but not hCB(1)-G(alpha 16). Colforsin 59-68 G protein subunit alpha 15 Homo sapiens 162-172 12137754-3 2002 AQP1 did not show any significant change of water permeability when treated with CT. An adenylyl cyclase accelerator forskolin showed similar effects as CT did, suggesting that changes of the water permeability of AQP4 and AQP3 were due to an increase of intracellular cAMP concentration. Colforsin 117-126 aquaporin 4 Homo sapiens 214-218 12065610-6 2002 This was prevented by the D(1) receptor antagonist SCH 23390 and the protein kinase A inhibitor H89, and reproduced by forskolin. Colforsin 119-128 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 69-85 12028440-4 2002 RESULTS: Pretreatment with 5 micromol/L forskolin significantly enhanced the [Ca2+]i response induced by 10-7 mol/L either Ang II or Ang III. Colforsin 40-49 angiotensinogen Rattus norvegicus 123-129 12028440-7 2002 Furthermore, the fact that the forskolin-induced potentiation of the [Ca2+]i response to Ang III was blocked by 10 micromol/L H-89, a specific protein kinase A (PKA) inhibitor, indicated that this effect occurred via activation of PKA. Colforsin 31-40 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 143-159 12028440-7 2002 Furthermore, the fact that the forskolin-induced potentiation of the [Ca2+]i response to Ang III was blocked by 10 micromol/L H-89, a specific protein kinase A (PKA) inhibitor, indicated that this effect occurred via activation of PKA. Colforsin 31-40 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 161-164 12028440-7 2002 Furthermore, the fact that the forskolin-induced potentiation of the [Ca2+]i response to Ang III was blocked by 10 micromol/L H-89, a specific protein kinase A (PKA) inhibitor, indicated that this effect occurred via activation of PKA. Colforsin 31-40 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 231-234 12137754-3 2002 AQP1 did not show any significant change of water permeability when treated with CT. An adenylyl cyclase accelerator forskolin showed similar effects as CT did, suggesting that changes of the water permeability of AQP4 and AQP3 were due to an increase of intracellular cAMP concentration. Colforsin 117-126 aquaporin 3 (Gill blood group) Homo sapiens 223-227 11886856-5 2002 However, only the type II PKA antagonist inhibits forskolin-induced Calpha and ethanol-induced Calpha and RIIbeta translocation to the nucleus and CREB phosphorylation; the type I antagonist is without effect. Colforsin 50-59 cAMP responsive element binding protein 1 Mus musculus 147-151 12065886-6 2002 Tyr(11)-SRIH-14, compound 2 (sst(2)) or compound 5 (sst(5)) inhibited forskolin and corticotropin-releasing hormone (CRH)-induced increases in intracellular cAMP. Colforsin 70-79 somatostatin receptor 2 Mus musculus 29-35 12065886-6 2002 Tyr(11)-SRIH-14, compound 2 (sst(2)) or compound 5 (sst(5)) inhibited forskolin and corticotropin-releasing hormone (CRH)-induced increases in intracellular cAMP. Colforsin 70-79 somatostatin receptor 5 Mus musculus 52-58 12111241-7 2002 The promoter region responsible for the stimulatory effect of forskolin/IBMX was narrowed down to three 4 bp of the mouse Ren1(C) gene, which are known as putative CRE-sites. Colforsin 62-71 renin 1 structural Mus musculus 122-129 11886856-6 2002 Our data suggest that forskolin- and ethanol-induced CREB phosphorylation and gene activation are differentially mediated by the two types of PKA. Colforsin 22-31 cAMP responsive element binding protein 1 Mus musculus 53-57 12053213-6 2002 Forskolin and 8-Br-cyclic adenosine monophosphate (cAMP) were used to activate cAMP-dependent Cl? Colforsin 0-9 cathelicidin antimicrobial peptide Homo sapiens 79-83 12053213-11 2002 In contrast, long-term exposure (24 hours) to physiological concentrations of progesterone (100 nM), but not estradiol, dose-dependently reduced the peak Isc induced by the cAMP-agonist forskolin from 125 +/- 2.7 mA. Colforsin 186-195 cathelicidin antimicrobial peptide Homo sapiens 173-177 11943650-5 2002 The inhibition of Grb2-SOS interaction with an SH3 binding sequence peptide, Ras with a farnesyl transferase inhibitor, and Raf-1 with forskolin did not affect the stretch-induced ERK1/2 phosphorylation. Colforsin 135-144 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 124-129 12016269-8 2002 Indeed, forskolin and 8-bromo-cAMP exert similar inhibitory effects on SMC migration as 11,12-EET and the effects of 11,12-EET were blocked by cAMP and protein kinase A (PKA) inhibitors. Colforsin 8-17 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 152-168 12016269-8 2002 Indeed, forskolin and 8-bromo-cAMP exert similar inhibitory effects on SMC migration as 11,12-EET and the effects of 11,12-EET were blocked by cAMP and protein kinase A (PKA) inhibitors. Colforsin 8-17 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 170-173 11988078-5 2002 Adenylate cyclase hyperactivation (by forskolin) could stimulate CREB phosphorylation to the same extent as noradrenaline. Colforsin 38-47 cAMP responsive element binding protein 1 Mus musculus 65-69 12044785-6 2002 In whole CHO(hNOP) cells [(pF)Phe(4)] and N/OFQ-(1-13)NH(2) inhibited forskolin stimulated cAMP formation with pEC(50) values of 10.19+/-0.06 and 9.60+/-0.04, respectively (P<0.05). Colforsin 70-79 prepronociceptin Homo sapiens 42-47 11934705-5 2002 In both cell types, the alpha(2B)-AR is coupled to G protein, and its stimulation by dexmedetomidine, but not by UK-14304, provoked a significant inhibition of the accumulation of cAMP induced by forskolin or parathyroid hormone. Colforsin 196-205 adrenoceptor alpha 2B Rattus norvegicus 24-36 11986218-8 2002 Incubation with histamine, forskolin, and epinephrine induced the rapid, coordinate release of both t-PA and VWF, consistent with a single storage compartment. Colforsin 27-36 plasminogen activator, tissue type Homo sapiens 100-104 11986218-8 2002 Incubation with histamine, forskolin, and epinephrine induced the rapid, coordinate release of both t-PA and VWF, consistent with a single storage compartment. Colforsin 27-36 von Willebrand factor Homo sapiens 109-112 11961135-5 2002 Both 12-O-tetradecanoylphorbol-13 acetate (TPA) and forskolin increased the synthesis of Fn. Colforsin 52-61 fibronectin 1 Rattus norvegicus 89-91 11967217-4 2002 In contrast, after luteinization of granulosa cells by 8-day treatment with forskolin, the Cox-2 promoter was immediately inducible by phorbol esters but not by cAMP. Colforsin 76-85 prostaglandin-endoperoxide synthase 2 Bos taurus 91-96 11967217-5 2002 In granulosa cells cultured for 8 days without forskolin, the Cox-2 promoter continued to be inducible only by cAMP and not by phorbol esters. Colforsin 47-56 prostaglandin-endoperoxide synthase 2 Bos taurus 62-67 11967217-8 2002 Time-course experiments showed that only 2 days of forskolin treatment could induce PKC-responsiveness of the Cox-2 promoter, although maximal responsiveness was not observed until 10 days of luteinization. Colforsin 51-60 prostaglandin-endoperoxide synthase 2 Bos taurus 110-115 11956164-7 2002 Furthermore, overexpression of its inactive mutant, Rab27b N133I, significantly inhibits basal and forskolin-induced ACTH secretion in AtT20 cells. Colforsin 99-108 RAB27B, member RAS oncogene family Mus musculus 52-58 11959692-4 2002 The cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine (IBMX) inhibited myocytic ANP release. Colforsin 26-35 natriuretic peptides A Oryctolagus cuniculus 94-97 11959692-5 2002 The activation of adenylyl cyclase with forskolin inhibited ANP release, which was a function of an increase in cAMP production. Colforsin 40-49 natriuretic peptides A Oryctolagus cuniculus 60-63 11959692-6 2002 Inhibitors for L-type Ca(2+) channels and protein kinase A (PKA) attenuated a minor portion of the forskolin-induced inhibition of ANP release. Colforsin 99-108 natriuretic peptides A Oryctolagus cuniculus 131-134 11959692-8 2002 The nonspecific protein kinase inhibitor staurosporine blocked forskolin-induced inhibition of ANP release in a dose-dependent manner. Colforsin 63-72 natriuretic peptides A Oryctolagus cuniculus 95-98 11970988-9 2002 Dibutyryl cAMP and forskolin down-regulated ICAM-1 and B7.2 expression in IL-18-stimulated monocytes. Colforsin 19-28 intercellular adhesion molecule 1 Homo sapiens 44-50 11970988-9 2002 Dibutyryl cAMP and forskolin down-regulated ICAM-1 and B7.2 expression in IL-18-stimulated monocytes. Colforsin 19-28 CD86 molecule Homo sapiens 55-59 11970988-9 2002 Dibutyryl cAMP and forskolin down-regulated ICAM-1 and B7.2 expression in IL-18-stimulated monocytes. Colforsin 19-28 interleukin 18 Homo sapiens 74-79 11933169-5 2002 After 24-hr cultivation in the maturation medium, COCs, which were cultured for an additional 24 hr in the presence of either forskolin or 3-isobutyl-1-methylxanthine (IBMX), exhibited a significant increase in the oocyte cAMP level to the similar level of that in oocytes cultured with PI 3-kinase inhibitor or PKC inhibitor, and the addition of each agent significantly suppressed meiotic progression from the MI to the MII stage and the activity of mitogen-activated protein kinase (MAPK) and p34(cdc2) kinase. Colforsin 126-135 leucine rich repeat containing 59 Homo sapiens 496-499 11933169-5 2002 After 24-hr cultivation in the maturation medium, COCs, which were cultured for an additional 24 hr in the presence of either forskolin or 3-isobutyl-1-methylxanthine (IBMX), exhibited a significant increase in the oocyte cAMP level to the similar level of that in oocytes cultured with PI 3-kinase inhibitor or PKC inhibitor, and the addition of each agent significantly suppressed meiotic progression from the MI to the MII stage and the activity of mitogen-activated protein kinase (MAPK) and p34(cdc2) kinase. Colforsin 126-135 cyclin dependent kinase 1 Homo sapiens 500-504 11961135-6 2002 However, the extracellular assembly of Fn fibril from both endogenously released and exogenously applied soluble Fn was increased by TPA but decreased by forskolin. Colforsin 154-163 fibronectin 1 Rattus norvegicus 39-41 11961135-6 2002 However, the extracellular assembly of Fn fibril from both endogenously released and exogenously applied soluble Fn was increased by TPA but decreased by forskolin. Colforsin 154-163 fibronectin 1 Rattus norvegicus 113-115 11880324-7 2002 cAMP agonists (100 microM dibutryl cAMP, 25 microM forskolin, 0.5 mM IBMX) increased the activity of a 2.2-kb UT-Aalpha promoter construct 6.2-fold [from 0.026 +/- 0.003 to 0.160 +/- 0.004, relative light units (RLU)/microg protein] and a 2.4-kb UT-Abeta promoter construct 9.5-fold (from 0.020 +/- 0.002 to 0.190 +/- 0.043 RLU/microg protein) above that in untreated controls. Colforsin 51-60 histocompatibility 2, class II antigen A, alpha Mus musculus 113-119 11973452-4 2002 When CB1 was heterologously over-expressed using a retroviral transfer, high concentrations of anandamide increased forskolin-induced cAMP accumulation, and this effect was more prominent when cells were pretreated with PTX. Colforsin 116-125 cannabinoid receptor 1 Rattus norvegicus 5-8 11976939-15 2002 Stimulation of PKA by forskolin activated a pronounced I(CFTR). Colforsin 22-31 ATP-binding cassette sub-family C member 7 Cavia porcellus 57-61 11916944-9 2002 VSMCs, PDE3 inhibition did markedly potentiate the forskolin-induced inhibition of migration of cp/cp-derived VSMCs. Colforsin 51-60 phosphodiesterase 3A Rattus norvegicus 7-11 11964604-15 2002 In addition, elevating myocardial cyclic AMP with forskolin also blocked release of TNF-alpha stimulated by HX-XO. Colforsin 50-59 tumor necrosis factor Rattus norvegicus 84-93 11897707-5 2002 This effect was cAMP-independent but additive to the cAMP-mediated increase in FSHR gene expression induced by either forskolin or vasoactive intestinal peptide, a neurotransmitter previously shown to induce FSHR formation in neonatal rat ovaries. Colforsin 118-127 follicle stimulating hormone receptor Rattus norvegicus 79-83 11897707-5 2002 This effect was cAMP-independent but additive to the cAMP-mediated increase in FSHR gene expression induced by either forskolin or vasoactive intestinal peptide, a neurotransmitter previously shown to induce FSHR formation in neonatal rat ovaries. Colforsin 118-127 follicle stimulating hormone receptor Rattus norvegicus 208-212 11903058-7 2002 In transient transfection experiments, NCoR and the related silencing mediator for retinoid and thyroid hormone receptor (SMRT) were shown to exert a marked dose-dependent repression of ligand-induced PPAR delta-mediated transactivation; in addition, transactivation induced by the cAMP-elevating agent forskolin was efficiently reduced to basal levels by NCoR as well as SMRT coexpression. Colforsin 303-312 nuclear receptor corepressor 1 Homo sapiens 39-43 11903058-7 2002 In transient transfection experiments, NCoR and the related silencing mediator for retinoid and thyroid hormone receptor (SMRT) were shown to exert a marked dose-dependent repression of ligand-induced PPAR delta-mediated transactivation; in addition, transactivation induced by the cAMP-elevating agent forskolin was efficiently reduced to basal levels by NCoR as well as SMRT coexpression. Colforsin 303-312 nuclear receptor corepressor 2 Homo sapiens 122-126 11903058-7 2002 In transient transfection experiments, NCoR and the related silencing mediator for retinoid and thyroid hormone receptor (SMRT) were shown to exert a marked dose-dependent repression of ligand-induced PPAR delta-mediated transactivation; in addition, transactivation induced by the cAMP-elevating agent forskolin was efficiently reduced to basal levels by NCoR as well as SMRT coexpression. Colforsin 303-312 peroxisome proliferator activated receptor delta Homo sapiens 201-211 11934645-6 2002 Both forskolin and dibutyryl-cAMP mimicked the regulation of RANKL and OPG transcription in clinostat culture. Colforsin 5-14 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 61-66 11934645-6 2002 Both forskolin and dibutyryl-cAMP mimicked the regulation of RANKL and OPG transcription in clinostat culture. Colforsin 5-14 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 71-74 11857482-8 2002 TNFalpha did not affect basal or hCG-stimulated cAMP levels, but did inhibit forskolin (0.5 microM; adenylate cyclase activator) and 8-bromo-cAMP (0.15 mM; cAMP analog) stimulated T levels. Colforsin 77-86 tumor necrosis factor Mus musculus 0-8 12006113-3 2002 The expression of this inducible cAMP early repressor (ICER) was shown to be coincident with the time and concentration dependency of the repression of CRE-mediated luciferase gene expression on the treatment of CHO cells with forskolin. Colforsin 227-236 cAMP responsive element modulator Rattus norvegicus 55-59 12039071-5 2002 Forskolin (0.001-100 microM) activated ERK, while inhibition of protein kinase A (PKA) by H89 (0.01-10 microM) suppressed pERK levels and all GnRH-stimulated gonadotropin subunit transcripts. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 39-42 11897397-5 2002 DmNPF inhibited forskolin-stimulated adenylyl cyclase activity similarly (IC(50) = 51 nM). Colforsin 16-25 neuropeptide F Drosophila melanogaster 0-5 12022018-1 2002 BACKGROUND: To determine whether nitric oxide synthase (NOS) protein expression can be modulated by forskolin in porcine ciliary processes. Colforsin 100-109 nitric oxide synthase 1 Homo sapiens 33-54 11923475-7 2002 This promoter showed the strong activity in the pituitary-derived GH4C1 cells, and the region between -697 and -596 bp was responsible for the stimulation both by forskolin and overexpression of cAMP response element binding protein (CREB). Colforsin 163-172 cAMP responsive element binding protein 1 Rattus norvegicus 234-238 11773060-5 2002 In contrast, ENaC currents in oocytes co-expressing ENaC and DeltaF508-CFTR remained stable following stimulation with forskolin/IBMX/genistein. Colforsin 119-128 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 71-75 11782489-5 2002 Moreover, forskolin and cyclic 8-bromo-AMP fully reproduced the effects of AVP on AQP2 expression. Colforsin 10-19 aquaporin 2 Mus musculus 82-86 11773060-6 2002 Furthermore, co-expression of DeltaF508-CFTR with ENaC enhanced the forskolin/IBMX/genistein-mediated activation of DeltaF508-CFTR. Colforsin 68-77 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 40-44 11773060-6 2002 Furthermore, co-expression of DeltaF508-CFTR with ENaC enhanced the forskolin/IBMX/genistein-mediated activation of DeltaF508-CFTR. Colforsin 68-77 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 126-130 11909603-4 2002 In Chinese hamster ovary (CHO) cells expressing human SLC-1, T-226296 reversed the MCH-mediated inhibition of forskolin-stimulated cAMP accumulation, inhibited MCH-induced intracellular Ca2+ increase, and also inhibited MCH-stimulated arachidonic acid release. Colforsin 110-119 melanin concentrating hormone receptor 1 Homo sapiens 54-59 11870874-7 2002 If cells are maintained in olfactory mitogen medium alone, or if they are treated with forskolin or fibroblast growth factor 2 diluted in serum-free medium, O4 and low-affinity nerve growth factor receptor expression remains at 100%, but there is also an increase in expression of E-NCAM, the astrocyte-like marker. Colforsin 87-96 nerve growth factor receptor Homo sapiens 164-205 11866452-4 2002 The expression of annexin 5 mRNA was also augmented by phorbol 12-myristate 13-acetate but not by forskolin. Colforsin 98-107 annexin A5 Rattus norvegicus 18-27 11909603-4 2002 In Chinese hamster ovary (CHO) cells expressing human SLC-1, T-226296 reversed the MCH-mediated inhibition of forskolin-stimulated cAMP accumulation, inhibited MCH-induced intracellular Ca2+ increase, and also inhibited MCH-stimulated arachidonic acid release. Colforsin 110-119 pro-melanin concentrating hormone Homo sapiens 83-86 11832360-5 2002 RGS2 mRNA levels were also elevated by treatment with Ca(2+) ionophore, phorbol ester, or forskolin. Colforsin 90-99 regulator of G protein signaling 2 Homo sapiens 0-4 11861501-9 2002 Experiments with the PKA inhibitor 14-22 amide and forskolin, as well as the measurement of intracellular cAMP, suggested the downstream involvement of cAMP-PKA pathway in CRH-induced inhibition of Ishikawa cell growth. Colforsin 51-60 corticotropin releasing hormone Homo sapiens 172-175 11872668-3 2002 The response to GLP-1 was mimicked by forskolin and largely inhibited by the protein kinase A (PKA) inhibitors, H89 and myristoylated PKI(14--22) amide, indicating partial mediation via a cAMP/PKA pathway. Colforsin 38-47 glucagon Rattus norvegicus 16-21 11911837-6 2002 D(4) receptors, however, exhibited a similar degree of inhibition of forskolin-stimulated cAMP production in ABP-280-deficient M2 cells and ABP-280-replent M2 subclones (A7 cells). Colforsin 69-78 filamin C Homo sapiens 109-116 11861504-6 2002 The reduction of GATA-1 mRNA by cAMP can be mimicked by treatment with forskolin, which elevates intracellular cAMP levels. Colforsin 71-80 GATA binding protein 1 Mus musculus 17-23 11861509-2 2002 Human LH (hLH), hCG, and agents that indirectly elevate cAMP [cholera toxin, forskolin, (Bu)(2)cAMP], time- and dose-dependently activated ERK1/2 in hGL cells. Colforsin 77-86 mitogen-activated protein kinase 3 Homo sapiens 139-145 11861509-2 2002 Human LH (hLH), hCG, and agents that indirectly elevate cAMP [cholera toxin, forskolin, (Bu)(2)cAMP], time- and dose-dependently activated ERK1/2 in hGL cells. Colforsin 77-86 LLGL scribble cell polarity complex component 2 Homo sapiens 149-152 11861509-5 2002 In contrast, both inhibitors blocked cholera toxin-, forskolin-, and (Bu)(2)cAMP-induced ERK1/2 phosphorylation concomitant with a reduction in progesterone secretion. Colforsin 53-62 mitogen-activated protein kinase 3 Homo sapiens 89-95 11857679-9 2002 Exposure of 6-month denervated nerve explants to TGF-beta/forskolin increased the number of motor neurons that regenerated through them from 258 +/-13; mean +/- SE to 442 +/- 22. Colforsin 58-67 transforming growth factor, beta 1 Rattus norvegicus 49-57 11856765-6 2002 Enzyme activity in HUVEC (318 +/- 56 fmoles 1,25(OH)(2)D(3)/hr/mg protein) increased after treatment with tumor necrosis factor-alpha (1054 +/- 166, P < 0.01), lipopolysaccharide (1381 +/- 88, P < 0.01), or forskolin (554 +/- 56, P < 0.05). Colforsin 213-222 tumor necrosis factor Homo sapiens 106-133 12126060-8 2002 Immunohistochemical investigation further revealed the VEGF-expressed cells in the sponge granulation tissues to be fibroblasts, and the intensity of positive reactions was enhanced by bFGF, 8-bromo-cAMP, forskolin, and amrinone. Colforsin 205-214 vascular endothelial growth factor A Rattus norvegicus 55-59 11874707-10 2002 The effects of FSK and the PTP inhibitors on cell rounding were reflected in their effects on steroid production since PV and CP also inhibited FSK-stimulated steroid production. Colforsin 144-147 cell division cycle 25C Homo sapiens 27-30 11870225-0 2002 Forskolin-mediated G1 arrest in acute lymphoblastic leukaemia cells: phosphorylated pRB sequesters E2Fs. Colforsin 0-9 RB transcriptional corepressor 1 Homo sapiens 84-87 11870225-2 2002 As expected, we observed a rapid dephosphorylation of the retinoblastoma protein (pRB) within 2 hours of forskolin treatment concomitant with reduced activity of the pRB-specific kinases. Colforsin 105-114 RB transcriptional corepressor 1 Homo sapiens 82-85 11870225-6 2002 It was therefore interesting to find that the phosphatase inhibitor, tautomycin, was able to abolish the forskolin-mediated dephosphorylation of pRB, without increasing the activities of the pRB-specific kinases. Colforsin 105-114 RB transcriptional corepressor 1 Homo sapiens 145-148 11870225-9 2002 Surprisingly, however, prolonged treatment with forskolin, which induced partial rephosphorylation of pRB, in fact further increased the complex formation between the E2Fs and pRB, and this also resulted in reduced E2F-promoter activity in vivo. Colforsin 48-57 RB transcriptional corepressor 1 Homo sapiens 102-105 11815454-3 2002 In the presence of 250 micromol/l diazoxide, simultaneous application of forskolin and 16.7 mmol/l glucose strongly stimulated insulin release: fourfold and eightfold increases with 1 and 30 micromol/l forskolin, respectively. Colforsin 73-82 insulin Homo sapiens 127-134 11870225-9 2002 Surprisingly, however, prolonged treatment with forskolin, which induced partial rephosphorylation of pRB, in fact further increased the complex formation between the E2Fs and pRB, and this also resulted in reduced E2F-promoter activity in vivo. Colforsin 48-57 RB transcriptional corepressor 1 Homo sapiens 176-179 12071471-6 2002 In Chinese hamster ovary cells expressing both the cystic fibrosis transmembrane conductance regulator chloride channel and P2.6 receptor, melatonin counteracted the forskolin induced activation of the channel. Colforsin 166-175 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 51-102 12071471-6 2002 In Chinese hamster ovary cells expressing both the cystic fibrosis transmembrane conductance regulator chloride channel and P2.6 receptor, melatonin counteracted the forskolin induced activation of the channel. Colforsin 166-175 transmembrane p24 trafficking protein 3 Homo sapiens 124-128 11906205-3 2002 TGFbeta1 antagonized the effects of forskolin on the mRNA levels of the transcription factors Oct-6/tst-1/SCIP and Krox20. Colforsin 36-45 transforming growth factor, beta 1 Rattus norvegicus 0-8 11906205-3 2002 TGFbeta1 antagonized the effects of forskolin on the mRNA levels of the transcription factors Oct-6/tst-1/SCIP and Krox20. Colforsin 36-45 POU class 3 homeobox 1 Rattus norvegicus 94-99 11906205-3 2002 TGFbeta1 antagonized the effects of forskolin on the mRNA levels of the transcription factors Oct-6/tst-1/SCIP and Krox20. Colforsin 36-45 POU class 3 homeobox 1 Rattus norvegicus 100-105 11906205-3 2002 TGFbeta1 antagonized the effects of forskolin on the mRNA levels of the transcription factors Oct-6/tst-1/SCIP and Krox20. Colforsin 36-45 POU class 3 homeobox 1 Rattus norvegicus 106-110 11906205-3 2002 TGFbeta1 antagonized the effects of forskolin on the mRNA levels of the transcription factors Oct-6/tst-1/SCIP and Krox20. Colforsin 36-45 early growth response 2 Rattus norvegicus 115-121 11788448-4 2002 An AQP1 chimera (AQP1 with an AQP2 tail: AQP1/2-N220) was located only in the AM independent of forskolin treatment. Colforsin 96-105 aquaporin-1 Canis lupus familiaris 3-7 11788448-4 2002 An AQP1 chimera (AQP1 with an AQP2 tail: AQP1/2-N220) was located only in the AM independent of forskolin treatment. Colforsin 96-105 aquaporin-1 Canis lupus familiaris 17-21 11788448-4 2002 An AQP1 chimera (AQP1 with an AQP2 tail: AQP1/2-N220) was located only in the AM independent of forskolin treatment. Colforsin 96-105 aquaporin-1 Canis lupus familiaris 17-21 11788448-5 2002 Forskolin increased the apical expression of AQP1 and AQP1/2-N220 less than twofold; that of AQP2 increased more than fourfold with concomitant changes in osmotic water permeabilities. Colforsin 0-9 aquaporin-1 Canis lupus familiaris 45-49 11788448-5 2002 Forskolin increased the apical expression of AQP1 and AQP1/2-N220 less than twofold; that of AQP2 increased more than fourfold with concomitant changes in osmotic water permeabilities. Colforsin 0-9 aquaporin-1 Canis lupus familiaris 54-58 11861327-7 2002 The density of beta(2)-adrenoceptors was significantly reduced in lung membranes harvested from IL-1beta-treated rats, which was associated with impaired isoproterenol- and forskolin-stimulated cyclic AMP accumulation and adenylyl cyclase (AC) activity ex vivo. Colforsin 173-182 interleukin 1 beta Rattus norvegicus 96-104 11861327-8 2002 Dexamethasone did not prevent IL-1beta-induced down-regulation of beta(2)-adrenoceptors but completely blocked IL-1beta-induced impairment of cyclic AMP accumulation and AC activity stimulated by isoproterenol and forskolin. Colforsin 214-223 interleukin 1 beta Rattus norvegicus 111-119 11948252-8 2002 A construct containing the composite STAT/CRE/AP1 site was responsive to cyclic AMP induction by forskolin in GH3 cells. Colforsin 97-106 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 46-49 11948252-9 2002 Forskolin treatment also resulted in a 4.5-fold increase in CART mRNA levels after 6 h and the addition of H89, an inhibitor of protein kinase A, reduced the levels by 50%. Colforsin 0-9 CART prepropeptide Rattus norvegicus 60-64 11853684-1 2002 We have investigated the effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively. Colforsin 36-45 solute carrier family 5 member 1 Homo sapiens 109-114 11853684-1 2002 We have investigated the effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively. Colforsin 36-45 solute carrier family 2 member 2 Homo sapiens 119-124 11853684-2 2002 Forskolin treatment increased SGLT1 but decreased GLUT2 expression in mid and lower villus enterocytes. Colforsin 0-9 solute carrier family 5 member 1 Homo sapiens 30-35 11853684-2 2002 Forskolin treatment increased SGLT1 but decreased GLUT2 expression in mid and lower villus enterocytes. Colforsin 0-9 solute carrier family 2 member 2 Homo sapiens 50-55 11842109-5 2002 Transactivation by c-Maf was inhibited by activation of protein kinase A (PKA) (by signal transduction agonist forskolin) or of protein kinase C (PKC) (by signal transduction agonist tetradecanoyl phorbol acetate). Colforsin 111-120 MAF bZIP transcription factor Rattus norvegicus 19-24 11842109-5 2002 Transactivation by c-Maf was inhibited by activation of protein kinase A (PKA) (by signal transduction agonist forskolin) or of protein kinase C (PKC) (by signal transduction agonist tetradecanoyl phorbol acetate). Colforsin 111-120 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 56-72 11842109-5 2002 Transactivation by c-Maf was inhibited by activation of protein kinase A (PKA) (by signal transduction agonist forskolin) or of protein kinase C (PKC) (by signal transduction agonist tetradecanoyl phorbol acetate). Colforsin 111-120 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 74-77 11818328-4 2002 ET-1 (10(-9)-10(-7) mol/L) stimulated DNA synthesis (147 +/- 10% of control subjects; p < 0.05) and attenuated the antiproliferative action of cicaprost and forskolin on PASMCs, these effects being mediated via ET(A) and ET(B) receptors. Colforsin 160-169 endothelin 1 Homo sapiens 0-4 11827689-7 2002 Increasing PLB phosphorylation by forskolin in isolated cardiomyocytes after inhibition of the Na(+)-Ca(2+) exchanger activity had significantly greater effect on SERCA2 activity in failing than in sham cells (49 and 20% faster transient decline, respectively). Colforsin 34-43 phospholamban Rattus norvegicus 11-14 11815454-3 2002 In the presence of 250 micromol/l diazoxide, simultaneous application of forskolin and 16.7 mmol/l glucose strongly stimulated insulin release: fourfold and eightfold increases with 1 and 30 micromol/l forskolin, respectively. Colforsin 202-211 insulin Homo sapiens 127-134 11815454-4 2002 alpha-Ketoisocaproate (KIC) and 3-isobutylmethylxanthine (IBMX) could be used in place of glucose and forskolin, respectively, to trigger insulin release in the presence of diazoxide. Colforsin 102-111 insulin Homo sapiens 138-145 11815454-5 2002 Triggering of insulin release by a combination of nutrients and forskolin was not attenuated by 10 micromol/l nifedipine (a blocker of voltage-dependent Ca(2+) channels) and 2 micromol/l thapsigargin (an inhibitor of intracellular Ca(2+)-ATPase), ascertaining independence of this phenomenon from Ca(2+) entry and from intracellular Ca(2+) liberation. Colforsin 64-73 insulin Homo sapiens 14-21 11804623-5 2002 The PDE IV inhibitors, a beta-adrenergic agonist isoproterenol and an adenylyl cyclase stimulant forskolin suppressed the proliferation of microglial cells as revealed by PCNA-immunocytochemical staining. Colforsin 97-106 proliferating cell nuclear antigen Rattus norvegicus 171-175 11836300-6 2002 Moreover, the release of BDNF was enhanced upon stimulation with cAMP or forskolin, an activator of cAMP. Colforsin 73-82 brain derived neurotrophic factor Homo sapiens 25-29 11931349-0 2002 Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-stimulated cyclic AMP synthesis in rat cerebral cortical slices: interaction with noradrenaline, adrenaline, and forskolin. Colforsin 198-207 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-50 11818505-2 2002 IGF-I did not modify NIS mRNA levels but inhibited TSH- and forskolin-induced NIS mRNA expression in a dose-dependent manner. Colforsin 60-69 insulin-like growth factor 1 Rattus norvegicus 0-5 12047811-8 2002 The BFP-induced I(SC) could be mimicked by forskolin (10 microM), but inhibited by a pretreatment of the cells with adenylate cyclase inhibitor, MDL-12330A (10 microM). Colforsin 43-52 ring finger protein 112 Homo sapiens 4-7 11850806-5 2002 Elevations in cAMP following treatment with forskolin, 8BrcAMP or IBMX rescued cells from SNP-induced cell death. Colforsin 44-53 cathelicidin antimicrobial peptide Rattus norvegicus 14-18 11816015-7 2002 Furthermore, estrone induced a two-fold increase in connexin 43 (Cx43) and a 30% decrease in Cx32 expression, while forskolin caused a 50% reduction in Cx32 with no effect on Cx43 expression in RWPE-1 cells. Colforsin 116-125 gap junction protein beta 1 Homo sapiens 152-156 11761161-6 2002 But forskolin, a direct activator of adenylyl cyclase, and SBr cAMP, a cell-permeable analogue of cAMP, caused Cx 43 channel clustering in cells attached to polystyrene. Colforsin 4-13 gap junction protein, alpha 1 Mus musculus 111-116 11694504-8 2002 Furthermore, type II InsP(3) receptors (InsP(3)R) were shown to be directly phosphorylated by a protein kinase A (PKA)-mediated mechanism after treatment with forskolin. Colforsin 159-168 inositol 1,4,5-trisphosphate receptor 1 Mus musculus 13-48 11742832-6 2002 Activation of adenylate cyclase/PKA by forskolin (10 microM) mimicked the effect of PTH by significantly reducing net P(i) reabsorption by one-half. Colforsin 39-48 parathyroid hormone Gallus gallus 84-87 11860154-8 2002 An increase in ANP secretion by N/OFQ was also partially blocked by the pretreatment of forskolin. Colforsin 88-97 natriuretic peptide A Rattus norvegicus 15-18 11790817-10 2002 In addition, forskolin (10 microM), which activates the cystic fibrosis transmembrane conductance regulator Cl(-) conductance in these cells and depolarises the cell membrane, had no effect on recovery. Colforsin 13-22 CF transmembrane conductance regulator Homo sapiens 56-107 11788480-7 2002 Indeed, Rap1 activation parallels the iloprost- and forskolin-induced Ca(2+) increase and is unaffected by the calcium chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N",N",-tetraacetic acid-AM. Colforsin 52-61 RAP1A, member of RAS oncogene family Homo sapiens 8-12 12180265-6 2002 The clustering of integrin and vinculin was enhanced and inhibited by TPA and forskolin, respectively. Colforsin 78-87 vinculin Bos taurus 31-39 11786499-2 2002 We recently reported that nociceptin/orphanin FQ (N/OFQ) inhibited forskolin-stimulated adenylyl cyclase activity and increased basal enzyme activity in membranes of the external plexiform layer (EPL) and granule cell layer (GRL), respectively, of the rat main olfactory bulb. Colforsin 67-76 prepronociceptin Rattus norvegicus 26-36 11786499-2 2002 We recently reported that nociceptin/orphanin FQ (N/OFQ) inhibited forskolin-stimulated adenylyl cyclase activity and increased basal enzyme activity in membranes of the external plexiform layer (EPL) and granule cell layer (GRL), respectively, of the rat main olfactory bulb. Colforsin 67-76 prepronociceptin Rattus norvegicus 37-48 12180265-8 2002 Aprotinin and leupeptin selectively antagonized the Fn degradative action of forskolin, but not that caused by H-7. Colforsin 77-86 pancreatic trypsin inhibitor Bos taurus 0-9 12180265-8 2002 Aprotinin and leupeptin selectively antagonized the Fn degradative action of forskolin, but not that caused by H-7. Colforsin 77-86 fibronectin 1 Bos taurus 52-54 11815366-7 2002 The adenosine-induced GIRK currents were abolished by injection of pertussis toxin and CPA inhibited forskolin-stimulated cyclic AMP accumulation. Colforsin 101-110 potassium inwardly rectifying channel subfamily J member 3 S homeolog Xenopus laevis 22-26 11815367-3 2002 JTC-801 completely antagonized the suppression of nociceptin on forskolin-induced accumulation of cyclic AMP (IC(50) : 2.58 microM) using ORL(1) receptor expressing HeLa cells in vitro. Colforsin 64-73 prepronociceptin Homo sapiens 50-60 11815367-3 2002 JTC-801 completely antagonized the suppression of nociceptin on forskolin-induced accumulation of cyclic AMP (IC(50) : 2.58 microM) using ORL(1) receptor expressing HeLa cells in vitro. Colforsin 64-73 opioid related nociceptin receptor 1 Homo sapiens 138-144 11856314-7 2002 Finally, regulatory elements at the DHS in introns 10 and 18 may contribute to upregulation of CFTR gene transcription by forskolin and mitomycin C, respectively. Colforsin 122-131 CF transmembrane conductance regulator Homo sapiens 95-99 12242685-9 2002 Upon addition of forskolin (an activator of adenylate cyclase which has been shown previously to mimic the effect of ACTH on adrenal cells) to the culture medium, the level of A1 decreased approximately 70% by forskolin, whereas the levels of the other isoenzymes were slightly increased, and that of the unknown form doubled. Colforsin 17-26 proopiomelanocortin Homo sapiens 117-121 11754361-2 2002 Forskolin, an activator of the cAMP/PKA pathway, results in antagonism of Fas-dependent, activation-induced cell death (AICD) by suppressed expression of the FasL. Colforsin 0-9 Fas ligand (TNF superfamily, member 6) Mus musculus 158-162 11754361-3 2002 We report that forskolin-mediated induction of inducible cAMP early repressor (ICER) correlates with transcriptional attenuation of FasL expression in the AICD model 2B4 T cell hybridoma. Colforsin 15-24 cAMP responsive element modulator Mus musculus 47-77 11754361-3 2002 We report that forskolin-mediated induction of inducible cAMP early repressor (ICER) correlates with transcriptional attenuation of FasL expression in the AICD model 2B4 T cell hybridoma. Colforsin 15-24 cAMP responsive element modulator Mus musculus 79-83 11754361-3 2002 We report that forskolin-mediated induction of inducible cAMP early repressor (ICER) correlates with transcriptional attenuation of FasL expression in the AICD model 2B4 T cell hybridoma. Colforsin 15-24 Fas ligand (TNF superfamily, member 6) Mus musculus 132-136 11754361-4 2002 ICER is inducible in human peripheral blood CD3(+) T cells, but in CD19(+) B cells, its induction is less responsive to forskolin treatment. Colforsin 120-129 cAMP responsive element modulator Homo sapiens 0-4 11754361-4 2002 ICER is inducible in human peripheral blood CD3(+) T cells, but in CD19(+) B cells, its induction is less responsive to forskolin treatment. Colforsin 120-129 CD19 molecule Homo sapiens 67-71 11956024-8 2002 The effects of forskolin in a leptin and IL-6 context could not be explained at the promoter level, but rather events occurring upstream in the signalling cascade must be postulated to explain the differential co-regulatory effects. Colforsin 15-24 interleukin 6 Rattus norvegicus 41-45 12242685-9 2002 Upon addition of forskolin (an activator of adenylate cyclase which has been shown previously to mimic the effect of ACTH on adrenal cells) to the culture medium, the level of A1 decreased approximately 70% by forskolin, whereas the levels of the other isoenzymes were slightly increased, and that of the unknown form doubled. Colforsin 210-219 proopiomelanocortin Homo sapiens 117-121 11743222-4 2002 The inhibition of forskolin-induced renin secretion by endothelin-3 in primary cultures of mouse juxtaglomerular cells and by endothelin-1 in the isolated perfused rat kidney could not be blocked by naftidrofuryl. Colforsin 18-27 renin Rattus norvegicus 36-41 11948679-10 2002 Further analysis in UMR 106 cells demonstrated that PGE2, forskolin and dibutyryl cAMP increased UBP41 mRNA expression 4-, 4.5-, and 2.4-fold, respectively. Colforsin 58-67 ubiquitin specific peptidase 2 Gallus gallus 97-102 11743222-4 2002 The inhibition of forskolin-induced renin secretion by endothelin-3 in primary cultures of mouse juxtaglomerular cells and by endothelin-1 in the isolated perfused rat kidney could not be blocked by naftidrofuryl. Colforsin 18-27 endothelin 3 Mus musculus 55-67 11968023-11 2002 Functional analysis using RGS-2 overexpression suggests the potential negative regulatory effects of RGS-2 on PTH- and forskolin-induced cAMP production in osteoblastic cells. Colforsin 119-128 regulator of G-protein signaling 2 Rattus norvegicus 26-31 12210727-6 2002 Western blot analysis showed a rapid, fivefold increase, in GSTP1 protein levels after treatment with 25 microM forskolin, with a peak at 2 h post-treatment. Colforsin 112-121 glutathione S-transferase pi 1 Homo sapiens 60-65 11968023-11 2002 Functional analysis using RGS-2 overexpression suggests the potential negative regulatory effects of RGS-2 on PTH- and forskolin-induced cAMP production in osteoblastic cells. Colforsin 119-128 regulator of G-protein signaling 2 Rattus norvegicus 101-106 12210727-7 2002 The levels of phosphorylated CRE (Ser133) binding protein-1 (CREB-1) increased rapidly, sevenfold at 30 min, and reached 10-fold at 4 h following forskolin treatment. Colforsin 146-155 cAMP responsive element binding protein 1 Homo sapiens 61-67 12421622-11 2002 Thus, we examined whether A1254 activates PKA by increasing cAMP; 10 microM forskolin, but not A1254, elevated intracellular cAMP levels. Colforsin 76-85 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 42-45 11786384-5 2002 The re-addition of TSH or forskolin to the culture medium is able to restore to wild-type levels the expression of both Pax8 and Tg. Colforsin 26-35 paired box 8 Rattus norvegicus 120-124 11786384-5 2002 The re-addition of TSH or forskolin to the culture medium is able to restore to wild-type levels the expression of both Pax8 and Tg. Colforsin 26-35 thyroglobulin Rattus norvegicus 129-131 11786384-6 2002 We have determined that the action of TSH/forskolin on Pax8 is at the transcriptional level. Colforsin 42-51 paired box 8 Rattus norvegicus 55-59 12421622-6 2002 Cortical cultures treated with glutamate, forskolin or the phorbol ester phorbol 12-myristate 13-acetate exhibited robust increases in phospho-CREB. Colforsin 42-51 cAMP responsive element binding protein 1 Rattus norvegicus 143-147 11773320-4 2002 Relative to wild-type, the response induced by puff application of hypertonic solution was enhanced in a mutant, dunce, in which the cAMP level is elevated, or in wild-type embryos treated with forskolin, an activator of adenylyl cyclase, while protein kinase A (PKA) inhibitors decreased it. Colforsin 194-203 Protein kinase, cAMP-dependent, catalytic subunit 1 Drosophila melanogaster 245-261 11773320-4 2002 Relative to wild-type, the response induced by puff application of hypertonic solution was enhanced in a mutant, dunce, in which the cAMP level is elevated, or in wild-type embryos treated with forskolin, an activator of adenylyl cyclase, while protein kinase A (PKA) inhibitors decreased it. Colforsin 194-203 Protein kinase, cAMP-dependent, catalytic subunit 1 Drosophila melanogaster 263-266 12074893-10 2002 The protein kinase A activator forskolin and the protein kinase C activator phorbol 12,13-dibutyrate could mimic the effect of dopamine. Colforsin 31-40 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 4-20 11814622-2 2002 The Y(1) receptor agonist, [Leu(31),Pro(34)]-NPY, inhibited forskolin-stimulated cAMP production which was insensitive to thapsigargin or the CaM kinase II inhibitor, KN-93. Colforsin 60-69 neuropeptide Y Homo sapiens 45-48 11814622-7 2002 Consistently, [Leu(31),Pro(34)]-NPY induced trans-CREB mediated luciferase activity through a CaM kinase dependent pathway, and inhibited forskolin-stimulated luciferase gene expression. Colforsin 138-147 neuropeptide Y Homo sapiens 32-35 11739466-7 2001 Both basal and forskolin-stimulated 20 alpha HSD mRNA levels were increased in PCOS theca cells compared with normal theca cells. Colforsin 15-24 hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens 36-48 11739313-5 2001 CaSpF was greatly increased by the adenylate cyclase activator forskolin (100 nmol/L) in normal myocytes (iNOS not expressed), but this effect was suppressed (by 77%) in LPS myocytes (iNOS expressed). Colforsin 63-72 nitric oxide synthase 2 Homo sapiens 106-110 11739313-5 2001 CaSpF was greatly increased by the adenylate cyclase activator forskolin (100 nmol/L) in normal myocytes (iNOS not expressed), but this effect was suppressed (by 77%) in LPS myocytes (iNOS expressed). Colforsin 63-72 nitric oxide synthase 2 Homo sapiens 184-188 11739313-6 2001 When NO production by iNOS was inhibited by aminoguanidine (1 mmol/L), there was a further increase in the forskolin-induced CaSpF in LPS myocytes (to levels similar to the forskolin-stimulated CaSpF in normal myocytes). Colforsin 107-116 nitric oxide synthase 2 Homo sapiens 22-26 11698238-8 2001 In contrast, 8-bromo-cAMP or forskolin pretreatment blocked inhibition by NT-3 but not NGF. Colforsin 29-38 neurotrophin 3 Rattus norvegicus 74-78 11737051-9 2001 These results suggest that type 4 PDE inhibitors, alone or synergistically in combination with forskolin, inhibit PHA-induced IL-13 release from PBMC of atopic asthma patients by elevating intracellular cAMP concentrations. Colforsin 95-104 interleukin 13 Homo sapiens 126-131 11701442-4 2001 Forskolin and cholera toxin significantly suppressed the ET-1-stimulated accumulation of HSP27. Colforsin 0-9 endothelin 1 Mus musculus 57-61 11701442-4 2001 Forskolin and cholera toxin significantly suppressed the ET-1-stimulated accumulation of HSP27. Colforsin 0-9 heat shock protein 1 Mus musculus 89-94 11701442-6 2001 Forskolin reduced the p38 MAP kinase phosphorylation induced by ET-1 or 12-O-tetradecanoylphorbol-13-acetate (TPA). Colforsin 0-9 mitogen-activated protein kinase 14 Mus musculus 22-25 11701442-6 2001 Forskolin reduced the p38 MAP kinase phosphorylation induced by ET-1 or 12-O-tetradecanoylphorbol-13-acetate (TPA). Colforsin 0-9 endothelin 1 Mus musculus 64-68 11701442-9 2001 Forskolin, DBcAMP, and PGE(1) suppressed the ET-1-stimulated increase in the mRNA level for HSP27. Colforsin 0-9 endothelin 1 Mus musculus 45-49 11701442-9 2001 Forskolin, DBcAMP, and PGE(1) suppressed the ET-1-stimulated increase in the mRNA level for HSP27. Colforsin 0-9 heat shock protein 1 Mus musculus 92-97 11731549-12 2001 Consistent with these findings we confirmed that forskolin, a PKA activator, enhances the effect of NGF on the capsaicin response. Colforsin 49-58 nerve growth factor Homo sapiens 100-103 11728449-3 2001 Histamine as well as forskolin and dibutyryl cyclic AMP (Bt2-cAMP) stimulated the THP-1 monocytes to express the LOX-1 gene at the transcription level. Colforsin 21-30 GLI family zinc finger 2 Homo sapiens 82-87 11735278-13 2001 Promotion of cAMP generation by either ISP or FSK reduced TNF-alpha production by hypoxic cells. Colforsin 46-49 tumor necrosis factor Rattus norvegicus 58-67 11761027-9 2001 Colonic mucin secretion was significantly stimulated after intra-arterial infusion of 3-isobutyl-methylxanthine (IBMX, 100 microM) or forskolin (2-20 microM). Colforsin 134-143 solute carrier family 13 member 2 Rattus norvegicus 8-13 11708774-5 2001 In SK-MEL-37 cells, MCH inhibited forskolin-stimulated cyclic AMP accumulation and induced mitogen-activated protein kinase (MAPK) in a pertussis toxin-(PTX)-sensitive manner. Colforsin 34-43 pro-melanin concentrating hormone Homo sapiens 20-23 11723222-0 2001 Dopamine D2 receptor-induced heterologous sensitization of adenylyl cyclase requires Galphas: characterization of Galphas-insensitive mutants of adenylyl cyclase V. Whereas acute stimulation of Galphai/o-coupled receptors inhibits the activity of adenylyl cyclase, a delayed consequence of persistent activation of the receptors is heterologous sensitization, an enhanced responsiveness of adenylyl cyclase to activators such as forskolin or agonists of Galphas-coupled receptors. Colforsin 429-438 dopamine receptor D2 Homo sapiens 0-20 11723226-5 2001 In cells expressing alpha2A-ARs, UK-14,304 (5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine), an alpha2-AR agonist, inhibited (10 pM) and stimulated (1-10 nM) the accumulation of cAMP evoked by forskolin. Colforsin 205-214 adrenergic receptor, alpha 2a Mus musculus 20-27 11728449-3 2001 Histamine as well as forskolin and dibutyryl cyclic AMP (Bt2-cAMP) stimulated the THP-1 monocytes to express the LOX-1 gene at the transcription level. Colforsin 21-30 oxidized low density lipoprotein receptor 1 Homo sapiens 113-118 11728449-4 2001 This histamine effect on LOX-1 gene expression, via the histamine H2 receptor-mediated cAMP signal transduction pathway, was reduced after differentiation of the cells into macrophages, even though forskolin and Bt2-cAMP still enhanced the gene expression. Colforsin 198-207 oxidized low density lipoprotein receptor 1 Homo sapiens 25-30 11764007-8 2001 Cantharidin also decreased StAR protein levels and progesterone production induced by the adenylate cyclase activator forskolin (10(-5) M) or a cAMP analog 8-Br-cAMP (0.5 mM). Colforsin 118-127 steroidogenic acute regulatory protein Rattus norvegicus 27-31 11705398-4 2001 The lipid mediator inhibited forskolin-driven rises in cAMP by greater than 80% after introduction of the mouse or human S1P(5) DNAs into rat hepatoma RH7777 cells (IC(50) = 0.22 nM). Colforsin 29-38 sphingosine-1-phosphate receptor 5 Homo sapiens 121-127 11696370-4 2001 The effect of TNF-alpha on 11beta-HSD2 was reversed by inhibiting the mitogen-activated protein kinases ERK with PD-098050 and p38 by SB-202190, or by activating protein kinase A with forskolin. Colforsin 184-193 tumor necrosis factor Homo sapiens 14-23 11746390-7 2001 The mitogenic activity of HGF was potentiated by addition of heregulin (HRG), but inhibited by addition of forskolin. Colforsin 107-116 hepatocyte growth factor Rattus norvegicus 26-29 11546776-6 2001 In CHO-K1 cells expressing the P2Y(13) receptor, ADP and 2MeSADP had a biphasic effect on the forskolin-stimulated accumulation of cAMP: inhibition at nanomolar concentrations and potentiation at micromolar levels. Colforsin 94-103 purinergic receptor P2Y13 Homo sapiens 31-38 11696370-4 2001 The effect of TNF-alpha on 11beta-HSD2 was reversed by inhibiting the mitogen-activated protein kinases ERK with PD-098050 and p38 by SB-202190, or by activating protein kinase A with forskolin. Colforsin 184-193 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 27-38 11673900-7 2001 A unique feature of the AR-LUX assay is that effects on modulation of active endogenous AR-levels are reliably reflected in the luciferase induction response, as exemplified by vitamin D, all-trans-retinoic acid, epigallocatechin gallate, and forskolin. Colforsin 243-252 androgen receptor Homo sapiens 24-26 11600438-5 2001 CFTR function was assayed from the time course of cell fluorescence in response to extracellular addition of 100 mM I(-) followed by forskolin, resulting in decreased YFP fluorescence due to CFTR-mediated I(-) entry. Colforsin 133-142 CF transmembrane conductance regulator Homo sapiens 0-4 11600438-5 2001 CFTR function was assayed from the time course of cell fluorescence in response to extracellular addition of 100 mM I(-) followed by forskolin, resulting in decreased YFP fluorescence due to CFTR-mediated I(-) entry. Colforsin 133-142 CF transmembrane conductance regulator Homo sapiens 191-195 11600438-7 2001 In cells cultured on 96-well plastic dishes, the assay gave reproducible halide permeabilities from well to well and could reliably detect a 2% activation of CFTR-dependent halide transport produced by low concentrations of forskolin. Colforsin 224-233 CF transmembrane conductance regulator Homo sapiens 158-162 11595649-0 2001 Glucose and forskolin regulate IAPP gene expression through different signal transduction pathways. Colforsin 12-21 islet amyloid polypeptide Rattus norvegicus 31-35 11595649-2 2001 In the present study, we investigated the effects of glucose and forskolin on IAPP gene regulation in the INS-1 islet beta-cell line. Colforsin 65-74 islet amyloid polypeptide Rattus norvegicus 78-82 11595649-3 2001 Both glucose and forskolin increased the level of expression of this gene, as measured by Northern blot analysis, and increased IAPP gene transcription in a time- and concentration-dependent manner, as demonstrated in a reporter gene assay. Colforsin 17-26 islet amyloid polypeptide Rattus norvegicus 128-132 11595649-7 2001 Mutation of the cAMP regulatory element flanking the IAPP coding region resulted in the loss of most of the forskolin-stimulated IAPP gene promoter activity, whereas glucose-enhanced IAPP gene transcription was unaffected. Colforsin 108-117 islet amyloid polypeptide Rattus norvegicus 53-57 11595649-7 2001 Mutation of the cAMP regulatory element flanking the IAPP coding region resulted in the loss of most of the forskolin-stimulated IAPP gene promoter activity, whereas glucose-enhanced IAPP gene transcription was unaffected. Colforsin 108-117 islet amyloid polypeptide Rattus norvegicus 129-133 11595649-7 2001 Mutation of the cAMP regulatory element flanking the IAPP coding region resulted in the loss of most of the forskolin-stimulated IAPP gene promoter activity, whereas glucose-enhanced IAPP gene transcription was unaffected. Colforsin 108-117 islet amyloid polypeptide Rattus norvegicus 129-133 11595649-8 2001 These results demonstrate parallel and distinct regulatory pathways involved in glucose- and forskolin-induced IAPP gene expression in this model beta-cell system. Colforsin 93-102 islet amyloid polypeptide Rattus norvegicus 111-115 11597909-3 2001 Although the response to forskolin is CFTR mediated, the mechanisms responsible for the response to a chloride gradient are unknown. Colforsin 25-34 cystic fibrosis transmembrane conductance regulator Mus musculus 38-42 11597909-7 2001 The responses to low chloride and forskolin demonstrate significantly different pharmacological profiles to both DIDS and Rp-cAMPS, indicating that channels in addition to CFTR contribute to the low chloride response. Colforsin 34-43 cystic fibrosis transmembrane conductance regulator Mus musculus 172-176 11705454-0 2001 Regulation of human beta(1)-adrenergic receptors and their mRNA in neuroepithelioma SK-N-MC cells: effects of agonist, forskolin, and protein kinase A. Colforsin 119-128 adrenoceptor beta 1 Homo sapiens 20-48 11705454-4 2001 The differences between the effects of isoproterenol and forskolin on beta(1)-AR were unrelated to cyclic AMP levels, since both agents increased cyclic AMP equally. Colforsin 57-66 adrenoceptor beta 1 Homo sapiens 70-80 11606471-4 2001 Forskolin-induced AVP hnRNA expression was unaffected by blockage of neurotransmission by the sodium channel inhibitor, tetrodotoxin, indicating that forskolin acts directly on AVP cells in the PVN. Colforsin 150-159 arginine vasopressin Rattus norvegicus 177-180 11728004-8 2001 Dopamine as well as forskolin and dibutyryl cAMP-mediated stimulation of protein kinase A (PKA) was reduced in PTs of obese compared to lean rats. Colforsin 20-29 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 73-89 11728004-8 2001 Dopamine as well as forskolin and dibutyryl cAMP-mediated stimulation of protein kinase A (PKA) was reduced in PTs of obese compared to lean rats. Colforsin 20-29 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 91-94 11606471-5 2001 Dual staining in situ hybridization of forskolin-stimulated hypothalamic sections using both radio labeled AVP hnRNA and digoxigenin-labeled CRH mRNA probes revealed colocalization of both transcripts, indicating AVP hnRNA is expressed in the parvocellular neurons. Colforsin 39-48 arginine vasopressin Rattus norvegicus 107-110 11606471-2 2001 While AVP heteronuclear (hn) RNA was not detected in the PVN under basal conditions, a marked induction of AVP hnRNA was observed after 2 and 3 h incubation of slices with forskolin. Colforsin 172-181 arginine vasopressin Rattus norvegicus 6-9 11606471-2 2001 While AVP heteronuclear (hn) RNA was not detected in the PVN under basal conditions, a marked induction of AVP hnRNA was observed after 2 and 3 h incubation of slices with forskolin. Colforsin 172-181 arginine vasopressin Rattus norvegicus 107-110 11606471-5 2001 Dual staining in situ hybridization of forskolin-stimulated hypothalamic sections using both radio labeled AVP hnRNA and digoxigenin-labeled CRH mRNA probes revealed colocalization of both transcripts, indicating AVP hnRNA is expressed in the parvocellular neurons. Colforsin 39-48 corticotropin releasing hormone Rattus norvegicus 141-144 11606471-4 2001 Forskolin-induced AVP hnRNA expression was unaffected by blockage of neurotransmission by the sodium channel inhibitor, tetrodotoxin, indicating that forskolin acts directly on AVP cells in the PVN. Colforsin 0-9 arginine vasopressin Rattus norvegicus 18-21 11606471-4 2001 Forskolin-induced AVP hnRNA expression was unaffected by blockage of neurotransmission by the sodium channel inhibitor, tetrodotoxin, indicating that forskolin acts directly on AVP cells in the PVN. Colforsin 0-9 arginine vasopressin Rattus norvegicus 177-180 11606471-5 2001 Dual staining in situ hybridization of forskolin-stimulated hypothalamic sections using both radio labeled AVP hnRNA and digoxigenin-labeled CRH mRNA probes revealed colocalization of both transcripts, indicating AVP hnRNA is expressed in the parvocellular neurons. Colforsin 39-48 arginine vasopressin Rattus norvegicus 213-216 11606471-4 2001 Forskolin-induced AVP hnRNA expression was unaffected by blockage of neurotransmission by the sodium channel inhibitor, tetrodotoxin, indicating that forskolin acts directly on AVP cells in the PVN. Colforsin 150-159 arginine vasopressin Rattus norvegicus 18-21 11641420-7 2001 After a 3-min exposure to FSK, B-Raf was recruited to a vesicular compartment, where it colocalized with Rap1. Colforsin 26-29 B-Raf proto-oncogene, serine/threonine kinase Rattus norvegicus 31-36 11696583-4 2001 In Dio2(-/-) brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O(2) consumption are all reduced due to impaired cAMP generation. Colforsin 73-82 deiodinase, iodothyronine, type II Mus musculus 3-7 11696583-4 2001 In Dio2(-/-) brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O(2) consumption are all reduced due to impaired cAMP generation. Colforsin 73-82 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 115-119 11885966-6 2001 Immunohistochemical investigation further revealed the VEGF-expressed cells in the sponge granulation tissues to be fibroblasts, and the intensity of positive reactions was enhanced by 8-bromo-cAMP, forskolin and amrinone. Colforsin 199-208 vascular endothelial growth factor A Rattus norvegicus 55-59 11641420-3 2001 Accordingly, TSH, forskolin (FSK) and 8-bromo-cAMP induced a rapid (3 min) and transient activation of ERK1/2, as assessed by phosphorylation of myelin basic protein and ERK1/2. Colforsin 18-27 mitogen activated protein kinase 3 Rattus norvegicus 103-109 12020084-10 2001 Consistent with a signaling pathway involving D1 dopamine receptors, adenylate cyclase and protein kinase A (PKA), the selective D1 antagonist, SCH23390, inhibited the hyperpolarizing effect of dopamine; the activator of adenylate cyclase, forskolin, mimicked the dopaminergic effect, and H89, which inhibits PKA, significantly reduced the hyperpolarization induced by dopamine. Colforsin 240-249 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 91-107 11641420-3 2001 Accordingly, TSH, forskolin (FSK) and 8-bromo-cAMP induced a rapid (3 min) and transient activation of ERK1/2, as assessed by phosphorylation of myelin basic protein and ERK1/2. Colforsin 18-27 myelin basic protein Rattus norvegicus 145-165 11641420-3 2001 Accordingly, TSH, forskolin (FSK) and 8-bromo-cAMP induced a rapid (3 min) and transient activation of ERK1/2, as assessed by phosphorylation of myelin basic protein and ERK1/2. Colforsin 18-27 mitogen activated protein kinase 3 Rattus norvegicus 170-176 11641420-3 2001 Accordingly, TSH, forskolin (FSK) and 8-bromo-cAMP induced a rapid (3 min) and transient activation of ERK1/2, as assessed by phosphorylation of myelin basic protein and ERK1/2. Colforsin 29-32 mitogen activated protein kinase 3 Rattus norvegicus 103-109 11641420-3 2001 Accordingly, TSH, forskolin (FSK) and 8-bromo-cAMP induced a rapid (3 min) and transient activation of ERK1/2, as assessed by phosphorylation of myelin basic protein and ERK1/2. Colforsin 29-32 myelin basic protein Rattus norvegicus 145-165 11641420-3 2001 Accordingly, TSH, forskolin (FSK) and 8-bromo-cAMP induced a rapid (3 min) and transient activation of ERK1/2, as assessed by phosphorylation of myelin basic protein and ERK1/2. Colforsin 29-32 mitogen activated protein kinase 3 Rattus norvegicus 170-176 12020084-10 2001 Consistent with a signaling pathway involving D1 dopamine receptors, adenylate cyclase and protein kinase A (PKA), the selective D1 antagonist, SCH23390, inhibited the hyperpolarizing effect of dopamine; the activator of adenylate cyclase, forskolin, mimicked the dopaminergic effect, and H89, which inhibits PKA, significantly reduced the hyperpolarization induced by dopamine. Colforsin 240-249 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 109-112 11567778-9 2001 The NaF-induced IL-8 response was weakly augmented by the PKA stimulator forskolin and the G(i) inhibitor pertussis toxin. Colforsin 73-82 C-X-C motif chemokine ligand 8 Homo sapiens 4-7 11597569-5 2001 Stimulation of protein kinase A activity in EP4-HEK293 cells (10 microM forskolin or 1 mM 8-bromo-cAMP) did not induce EP4 desensitization, sequestration, or phosphorylation. Colforsin 72-81 prostaglandin E receptor 4 Homo sapiens 44-47 11514577-5 2001 Additionally, an increase in G protein-mediated inhibition of adenylate cyclase activity, measured by the inhibition of forskolin-mediated cAMP accumulation, could be detected in HEK293 and NIH3T3 cells after expression of hPBP and in Xenopus oocytes after injection of hPBP. Colforsin 120-129 phosphatidylethanolamine binding protein 1 Homo sapiens 223-227 11514577-5 2001 Additionally, an increase in G protein-mediated inhibition of adenylate cyclase activity, measured by the inhibition of forskolin-mediated cAMP accumulation, could be detected in HEK293 and NIH3T3 cells after expression of hPBP and in Xenopus oocytes after injection of hPBP. Colforsin 120-129 phosphatidylethanolamine binding protein 1 Homo sapiens 270-274 11594735-6 2001 Elevating the amount of cytosolic cAMP by preincubation with forskolin or Sp-cAMP also enhanced NMDA currents as effectively as BDNF in 18-day-old hippocampal neurons. Colforsin 61-70 brain derived neurotrophic factor Homo sapiens 128-132 11567778-9 2001 The NaF-induced IL-8 response was weakly augmented by the PKA stimulator forskolin and the G(i) inhibitor pertussis toxin. Colforsin 73-82 C-X-C motif chemokine ligand 8 Homo sapiens 16-20 11600673-4 2001 CICR was triggered by the GLP-1 receptor agonist exendin-4, an effect mimicked by caffeine, Sp-cAMPS or forskolin. Colforsin 104-113 glucagon-like peptide 1 receptor Rattus norvegicus 26-40 11600673-11 2001 CICR in response to forskolin was blocked by transient transfection and expression of a dominant negative mutant isoform of cAMP-GEF-II in which inactivating mutations were introduced into the exchange factor"s two cAMP-binding domains. Colforsin 20-29 Rap guanine nucleotide exchange factor 4 Rattus norvegicus 124-135 11573967-4 2001 Treatment of UMR106 cells with nonPTH activators of the cAMP/PKA signaling pathway such as cholera toxin, forskolin, 8-Br-cAMP, and dibutyryl-cAMP also significantly elevated RGS2 mRNA levels, while activator of the Galphaq pathway PMA did not. Colforsin 106-115 regulator of G-protein signaling 2 Rattus norvegicus 175-179 11573967-4 2001 Treatment of UMR106 cells with nonPTH activators of the cAMP/PKA signaling pathway such as cholera toxin, forskolin, 8-Br-cAMP, and dibutyryl-cAMP also significantly elevated RGS2 mRNA levels, while activator of the Galphaq pathway PMA did not. Colforsin 106-115 G protein subunit alpha q Rattus norvegicus 216-223 11546650-5 2001 NHE5 activity was inhibited by acute exposure to 8-bromo-cAMP or forskolin (which increases intracellular cAMP by activating adenylate cyclase). Colforsin 65-74 solute carrier family 9 member A5 Rattus norvegicus 0-4 11546650-5 2001 NHE5 activity was inhibited by acute exposure to 8-bromo-cAMP or forskolin (which increases intracellular cAMP by activating adenylate cyclase). Colforsin 65-74 cathelicidin antimicrobial peptide Rattus norvegicus 106-110 11573977-1 2001 Differential vasopressin (VP) gene expression and oxytocin (OT) gene expression were observed in hypothalamic cultures derived from 14-day-old rat fetuses, with VP but not OT being induced by treatment with forskolin and 3-isobutyl-1-methylxanthine. Colforsin 207-216 arginine vasopressin Rattus norvegicus 13-24 11557586-3 2001 Forskolin-induced adenylyl cyclase activity was inhibited by carbachol in GGTI-2147-pretreated cells, demonstrating that the effect of geranylgeranyltransferase I inhibition on stress fiber formation was not due to uncoupling of signaling between the heterotrimeric G(i) protein (the Ggamma subunit is isoprenylated) and distal effectors. Colforsin 0-9 protein geranylgeranyltransferase type I subunit beta Homo sapiens 74-78 11564698-3 2001 However, when granulosa cells were stimulated with either FSH or forskolin in the presence of activin-A, significant increases (P < 0.05) were observed for cyclin D2 and proliferating cell nuclear antigen at both the mRNA and protein levels as well as mRNAs for P450 aromatase, LH receptor, P450 cholesterol side-chain cleavage enzyme and 3 beta-hydroxysteroid dehydrogenase. Colforsin 65-74 inhibin subunit beta A Rattus norvegicus 94-103 11564698-3 2001 However, when granulosa cells were stimulated with either FSH or forskolin in the presence of activin-A, significant increases (P < 0.05) were observed for cyclin D2 and proliferating cell nuclear antigen at both the mRNA and protein levels as well as mRNAs for P450 aromatase, LH receptor, P450 cholesterol side-chain cleavage enzyme and 3 beta-hydroxysteroid dehydrogenase. Colforsin 65-74 cyclin D2 Rattus norvegicus 159-168 11564698-3 2001 However, when granulosa cells were stimulated with either FSH or forskolin in the presence of activin-A, significant increases (P < 0.05) were observed for cyclin D2 and proliferating cell nuclear antigen at both the mRNA and protein levels as well as mRNAs for P450 aromatase, LH receptor, P450 cholesterol side-chain cleavage enzyme and 3 beta-hydroxysteroid dehydrogenase. Colforsin 65-74 proliferating cell nuclear antigen Rattus norvegicus 173-207 11564698-3 2001 However, when granulosa cells were stimulated with either FSH or forskolin in the presence of activin-A, significant increases (P < 0.05) were observed for cyclin D2 and proliferating cell nuclear antigen at both the mRNA and protein levels as well as mRNAs for P450 aromatase, LH receptor, P450 cholesterol side-chain cleavage enzyme and 3 beta-hydroxysteroid dehydrogenase. Colforsin 65-74 luteinizing hormone/choriogonadotropin receptor Rattus norvegicus 281-292 11573977-1 2001 Differential vasopressin (VP) gene expression and oxytocin (OT) gene expression were observed in hypothalamic cultures derived from 14-day-old rat fetuses, with VP but not OT being induced by treatment with forskolin and 3-isobutyl-1-methylxanthine. Colforsin 207-216 arginine vasopressin Rattus norvegicus 161-163 11710991-3 2001 FSK did not affect the expression of CD4 or the T cell receptor (TCR) but did diminish levels of the phosphorylated (activated) mitogen-activated protein (MAP) kinases early response kinase-1 (ERK-1) and ERK-2. Colforsin 0-3 mitogen-activated protein kinase 3 Mus musculus 193-198 11571782-9 2001 Like primary rat Schwann cells, SpL201 cells upregulate Oct-6 and myelin gene expression in response to forskolin treatment. Colforsin 104-113 sphingosine-1-phosphate lyase 1 Rattus norvegicus 32-35 11571782-9 2001 Like primary rat Schwann cells, SpL201 cells upregulate Oct-6 and myelin gene expression in response to forskolin treatment. Colforsin 104-113 POU class 3 homeobox 1 Rattus norvegicus 56-61 11710991-3 2001 FSK did not affect the expression of CD4 or the T cell receptor (TCR) but did diminish levels of the phosphorylated (activated) mitogen-activated protein (MAP) kinases early response kinase-1 (ERK-1) and ERK-2. Colforsin 0-3 mitogen-activated protein kinase 1 Mus musculus 204-209 11710991-4 2001 Immunoblotting of lysates from an FSK-treated Th1 clone with antibodies to a carboxy-terminal epitope of p56(lck), a signal transduction enzyme upstream from ERK-1 and ERK2, did not detect p56(lck) unless the lysates were reduced prior to electrophoresis. Colforsin 34-37 negative elongation factor complex member C/D, Th1l Mus musculus 46-49 11710991-4 2001 Immunoblotting of lysates from an FSK-treated Th1 clone with antibodies to a carboxy-terminal epitope of p56(lck), a signal transduction enzyme upstream from ERK-1 and ERK2, did not detect p56(lck) unless the lysates were reduced prior to electrophoresis. Colforsin 34-37 interferon-induced protein with tetratricopeptide repeats 1 Mus musculus 105-108 11710991-4 2001 Immunoblotting of lysates from an FSK-treated Th1 clone with antibodies to a carboxy-terminal epitope of p56(lck), a signal transduction enzyme upstream from ERK-1 and ERK2, did not detect p56(lck) unless the lysates were reduced prior to electrophoresis. Colforsin 34-37 lymphocyte protein tyrosine kinase Mus musculus 109-112 11710991-4 2001 Immunoblotting of lysates from an FSK-treated Th1 clone with antibodies to a carboxy-terminal epitope of p56(lck), a signal transduction enzyme upstream from ERK-1 and ERK2, did not detect p56(lck) unless the lysates were reduced prior to electrophoresis. Colforsin 34-37 mitogen-activated protein kinase 3 Mus musculus 158-163 11710991-4 2001 Immunoblotting of lysates from an FSK-treated Th1 clone with antibodies to a carboxy-terminal epitope of p56(lck), a signal transduction enzyme upstream from ERK-1 and ERK2, did not detect p56(lck) unless the lysates were reduced prior to electrophoresis. Colforsin 34-37 mitogen-activated protein kinase 1 Mus musculus 168-172 11710991-4 2001 Immunoblotting of lysates from an FSK-treated Th1 clone with antibodies to a carboxy-terminal epitope of p56(lck), a signal transduction enzyme upstream from ERK-1 and ERK2, did not detect p56(lck) unless the lysates were reduced prior to electrophoresis. Colforsin 34-37 interferon-induced protein with tetratricopeptide repeats 1 Mus musculus 189-192 11710991-4 2001 Immunoblotting of lysates from an FSK-treated Th1 clone with antibodies to a carboxy-terminal epitope of p56(lck), a signal transduction enzyme upstream from ERK-1 and ERK2, did not detect p56(lck) unless the lysates were reduced prior to electrophoresis. Colforsin 34-37 lymphocyte protein tyrosine kinase Mus musculus 193-196 11710991-7 2001 N-acetylcysteine or catalase prevented FSK-induced suppression of antigen-induced proliferation and the loss of carboxy-terminal epitopes of p56(lck). Colforsin 39-42 lymphocyte protein tyrosine kinase Mus musculus 145-148 11710991-9 2001 In contrast, inhibitors of PKA or NOS, but not catalase, prevented FSK-induced suppression of IFN-gamma production. Colforsin 67-70 interferon gamma Mus musculus 94-103 11710991-10 2001 Moreover, immunoblots of lysates precipitated with anti-p56(lck), phosphotyrosine, or CD4 demonstrated that in FSK-treated, anti-CD3-stimulated cells, p56(lck) is not associated with CD4 zeta chain, nor is p56(lck) or zeta chain phosphorylated. Colforsin 111-114 interferon-induced protein with tetratricopeptide repeats 1 Mus musculus 56-59 11710991-10 2001 Moreover, immunoblots of lysates precipitated with anti-p56(lck), phosphotyrosine, or CD4 demonstrated that in FSK-treated, anti-CD3-stimulated cells, p56(lck) is not associated with CD4 zeta chain, nor is p56(lck) or zeta chain phosphorylated. Colforsin 111-114 lymphocyte protein tyrosine kinase Mus musculus 60-63 11710991-10 2001 Moreover, immunoblots of lysates precipitated with anti-p56(lck), phosphotyrosine, or CD4 demonstrated that in FSK-treated, anti-CD3-stimulated cells, p56(lck) is not associated with CD4 zeta chain, nor is p56(lck) or zeta chain phosphorylated. Colforsin 111-114 CD4 antigen Mus musculus 86-89 11710991-10 2001 Moreover, immunoblots of lysates precipitated with anti-p56(lck), phosphotyrosine, or CD4 demonstrated that in FSK-treated, anti-CD3-stimulated cells, p56(lck) is not associated with CD4 zeta chain, nor is p56(lck) or zeta chain phosphorylated. Colforsin 111-114 CD247 antigen Mus musculus 129-132 11710991-10 2001 Moreover, immunoblots of lysates precipitated with anti-p56(lck), phosphotyrosine, or CD4 demonstrated that in FSK-treated, anti-CD3-stimulated cells, p56(lck) is not associated with CD4 zeta chain, nor is p56(lck) or zeta chain phosphorylated. Colforsin 111-114 interferon-induced protein with tetratricopeptide repeats 1 Mus musculus 151-154 11710991-10 2001 Moreover, immunoblots of lysates precipitated with anti-p56(lck), phosphotyrosine, or CD4 demonstrated that in FSK-treated, anti-CD3-stimulated cells, p56(lck) is not associated with CD4 zeta chain, nor is p56(lck) or zeta chain phosphorylated. Colforsin 111-114 lymphocyte protein tyrosine kinase Mus musculus 155-158 11710991-10 2001 Moreover, immunoblots of lysates precipitated with anti-p56(lck), phosphotyrosine, or CD4 demonstrated that in FSK-treated, anti-CD3-stimulated cells, p56(lck) is not associated with CD4 zeta chain, nor is p56(lck) or zeta chain phosphorylated. Colforsin 111-114 CD4 antigen Mus musculus 183-186 11710991-10 2001 Moreover, immunoblots of lysates precipitated with anti-p56(lck), phosphotyrosine, or CD4 demonstrated that in FSK-treated, anti-CD3-stimulated cells, p56(lck) is not associated with CD4 zeta chain, nor is p56(lck) or zeta chain phosphorylated. Colforsin 111-114 interferon-induced protein with tetratricopeptide repeats 1 Mus musculus 151-154 11710991-10 2001 Moreover, immunoblots of lysates precipitated with anti-p56(lck), phosphotyrosine, or CD4 demonstrated that in FSK-treated, anti-CD3-stimulated cells, p56(lck) is not associated with CD4 zeta chain, nor is p56(lck) or zeta chain phosphorylated. Colforsin 111-114 lymphocyte protein tyrosine kinase Mus musculus 155-158 11710991-11 2001 In vitro kinase assays demonstrated that p56(lck) from FSK-treated cells does not have kinase activity. Colforsin 55-58 interferon-induced protein with tetratricopeptide repeats 1 Mus musculus 41-44 11710991-11 2001 In vitro kinase assays demonstrated that p56(lck) from FSK-treated cells does not have kinase activity. Colforsin 55-58 lymphocyte protein tyrosine kinase Mus musculus 45-48 11717004-0 2001 17beta-estradiol inhibits forskolin-induced vascular endothelial growth factor promoter in MCF-7 breast adenocarcinoma cells. Colforsin 26-35 vascular endothelial growth factor A Homo sapiens 44-78 11500310-6 2001 In addition, internalization of the wild-type receptor and the DSEL mutant is stimulated by the PTH analog [Gly(1),Arg(19)]hPTH-(1-28), which does not stimulate phospholipase C. Forskolin, IBMX, and the active phorbol ester, phorbol-12-myristate-13-acetate, did not promote receptor internalization or increase PTH-induced internalization. Colforsin 178-187 dermatan sulfate epimerase like Homo sapiens 63-67 11717004-4 2001 Moreover, estrogens, through estrogen receptors, partly inhibit the forskolin-induced VEGF promoter in MCF-7 human breast cancer cells. Colforsin 68-77 vascular endothelial growth factor A Homo sapiens 86-90 11459843-6 2001 Furthermore, activators (phorbol esters and forskolin) and inhibitors (Ro 31-8220 and H89) of protein kinase C or A, respectively, exhibit differential effects on NKA binding and associated responses; activated protein kinase C facilitates a switch between calcium and cAMP responses, whereas activation of protein kinase A diminishes cAMP responses. Colforsin 44-53 tachykinin precursor 1 Homo sapiens 163-166 11443126-3 2001 The mIP exhibited efficient G alpha(s) coupling and concentration-dependent increases in cAMP generation in response to the IP agonist cicaprost; however, mIP also coupled to G alpha(i) decreasing the levels of cAMP in forskolin-treated cells. Colforsin 219-228 major intrinsic protein of lens fiber Mus musculus 4-7 11443126-3 2001 The mIP exhibited efficient G alpha(s) coupling and concentration-dependent increases in cAMP generation in response to the IP agonist cicaprost; however, mIP also coupled to G alpha(i) decreasing the levels of cAMP in forskolin-treated cells. Colforsin 219-228 major intrinsic protein of lens fiber Mus musculus 5-7 11443126-3 2001 The mIP exhibited efficient G alpha(s) coupling and concentration-dependent increases in cAMP generation in response to the IP agonist cicaprost; however, mIP also coupled to G alpha(i) decreasing the levels of cAMP in forskolin-treated cells. Colforsin 219-228 major intrinsic protein of lens fiber Mus musculus 155-158 11669453-3 2001 TGF-beta1 and forskolin, an activator of the cAMP pathway, inhibited RA-induced expression of RAR-beta mRNA in MEPM cells, though only TGF-beta1 inhibited RA-induced RAR-beta protein expression. Colforsin 14-23 retinoic acid receptor, beta Mus musculus 94-102 11669453-3 2001 TGF-beta1 and forskolin, an activator of the cAMP pathway, inhibited RA-induced expression of RAR-beta mRNA in MEPM cells, though only TGF-beta1 inhibited RA-induced RAR-beta protein expression. Colforsin 14-23 retinoic acid receptor, beta Mus musculus 166-174 11669453-4 2001 Forskolin, but not TGF-beta1, abrogated RA-induced expression of a reporter construct containing 900 base pair (bp) of the RAR-beta gene promoter, transfected into MEPM cells, suggesting that this portion of the promoter contains the forskolin-responsive, but not the TGF-beta-responsive, element. Colforsin 0-9 retinoic acid receptor, beta Mus musculus 123-131 11669453-4 2001 Forskolin, but not TGF-beta1, abrogated RA-induced expression of a reporter construct containing 900 base pair (bp) of the RAR-beta gene promoter, transfected into MEPM cells, suggesting that this portion of the promoter contains the forskolin-responsive, but not the TGF-beta-responsive, element. Colforsin 234-243 retinoic acid receptor, beta Mus musculus 123-131 11410589-3 2001 Adenylate cyclase activation with forskolin (FSK) caused a time-dependent increase in ERK activity and translocation from cytoplasm to nucleus, which correlated with an increase in StAR mRNA levels, StAR protein accumulation, and steroidogenesis. Colforsin 34-43 mitogen-activated protein kinase 1 Homo sapiens 86-89 11410589-3 2001 Adenylate cyclase activation with forskolin (FSK) caused a time-dependent increase in ERK activity and translocation from cytoplasm to nucleus, which correlated with an increase in StAR mRNA levels, StAR protein accumulation, and steroidogenesis. Colforsin 34-43 steroidogenic acute regulatory protein Homo sapiens 181-185 11410589-3 2001 Adenylate cyclase activation with forskolin (FSK) caused a time-dependent increase in ERK activity and translocation from cytoplasm to nucleus, which correlated with an increase in StAR mRNA levels, StAR protein accumulation, and steroidogenesis. Colforsin 34-43 steroidogenic acute regulatory protein Homo sapiens 199-203 11410589-3 2001 Adenylate cyclase activation with forskolin (FSK) caused a time-dependent increase in ERK activity and translocation from cytoplasm to nucleus, which correlated with an increase in StAR mRNA levels, StAR protein accumulation, and steroidogenesis. Colforsin 45-48 mitogen-activated protein kinase 1 Homo sapiens 86-89 11410589-3 2001 Adenylate cyclase activation with forskolin (FSK) caused a time-dependent increase in ERK activity and translocation from cytoplasm to nucleus, which correlated with an increase in StAR mRNA levels, StAR protein accumulation, and steroidogenesis. Colforsin 45-48 steroidogenic acute regulatory protein Homo sapiens 181-185 11410589-3 2001 Adenylate cyclase activation with forskolin (FSK) caused a time-dependent increase in ERK activity and translocation from cytoplasm to nucleus, which correlated with an increase in StAR mRNA levels, StAR protein accumulation, and steroidogenesis. Colforsin 45-48 steroidogenic acute regulatory protein Homo sapiens 199-203 11410589-4 2001 Similarly, ERK inhibition led to a reduction in the levels of FSK-stimulated StAR mRNA, StAR protein, and steroid secretion. Colforsin 62-65 mitogen-activated protein kinase 1 Homo sapiens 11-14 11410589-4 2001 Similarly, ERK inhibition led to a reduction in the levels of FSK-stimulated StAR mRNA, StAR protein, and steroid secretion. Colforsin 62-65 steroidogenic acute regulatory protein Homo sapiens 77-81 11410589-4 2001 Similarly, ERK inhibition led to a reduction in the levels of FSK-stimulated StAR mRNA, StAR protein, and steroid secretion. Colforsin 62-65 steroidogenic acute regulatory protein Homo sapiens 88-92 11410589-6 2001 This conclusion was supported by our demonstration of an ERK-dependent increase in the binding of SF-1 from FSK-treated Y1 nuclei to three consensus double-stranded DNA sequences from the StAR promoter region. Colforsin 108-111 mitogen-activated protein kinase 1 Homo sapiens 57-60 11410589-6 2001 This conclusion was supported by our demonstration of an ERK-dependent increase in the binding of SF-1 from FSK-treated Y1 nuclei to three consensus double-stranded DNA sequences from the StAR promoter region. Colforsin 108-111 splicing factor 1 Homo sapiens 98-102 11410589-6 2001 This conclusion was supported by our demonstration of an ERK-dependent increase in the binding of SF-1 from FSK-treated Y1 nuclei to three consensus double-stranded DNA sequences from the StAR promoter region. Colforsin 108-111 steroidogenic acute regulatory protein Homo sapiens 188-192 11566196-6 2001 Treatment with forskolin increased the steady-state levels of ATA1 and ATA2 mRNAs, but decreased that of ATA3 mRNA. Colforsin 15-24 solute carrier family 38 member 1 Homo sapiens 62-66 11566196-6 2001 Treatment with forskolin increased the steady-state levels of ATA1 and ATA2 mRNAs, but decreased that of ATA3 mRNA. Colforsin 15-24 solute carrier family 38 member 2 Homo sapiens 71-75 11566196-6 2001 Treatment with forskolin increased the steady-state levels of ATA1 and ATA2 mRNAs, but decreased that of ATA3 mRNA. Colforsin 15-24 solute carrier family 38 member 4 Homo sapiens 105-109 11567621-5 2001 Tetanus and forskolin-induced activation of mitogen-activated protein kinase (MAPK) was blocked by PI-3 kinase inhibitors, which also inhibited cAMP response element binding protein (CREB) phosphorylation. Colforsin 12-21 cAMP responsive element binding protein 1 Rattus norvegicus 144-181 11567621-5 2001 Tetanus and forskolin-induced activation of mitogen-activated protein kinase (MAPK) was blocked by PI-3 kinase inhibitors, which also inhibited cAMP response element binding protein (CREB) phosphorylation. Colforsin 12-21 cAMP responsive element binding protein 1 Rattus norvegicus 183-187 11500310-6 2001 In addition, internalization of the wild-type receptor and the DSEL mutant is stimulated by the PTH analog [Gly(1),Arg(19)]hPTH-(1-28), which does not stimulate phospholipase C. Forskolin, IBMX, and the active phorbol ester, phorbol-12-myristate-13-acetate, did not promote receptor internalization or increase PTH-induced internalization. Colforsin 178-187 parathyroid hormone Homo sapiens 96-99 11514360-5 2001 TNF downregulates the expression of TbetaR II of insulin/forskolin-stimulated and of unstimulated cells. Colforsin 57-66 tumor necrosis factor Sus scrofa 0-3 11495722-6 2001 Interestingly, an increase of intracellular cAMP level with forskolin or 8-(4-chlorophenylthio)-cAMP augmented ERK1/2 phosphorylation by H(2)O(2), while inhibiting MEK1/2 phosphorylation by H(2)O(2). Colforsin 60-69 mitogen-activated protein kinase 3 Homo sapiens 111-117 11495722-6 2001 Interestingly, an increase of intracellular cAMP level with forskolin or 8-(4-chlorophenylthio)-cAMP augmented ERK1/2 phosphorylation by H(2)O(2), while inhibiting MEK1/2 phosphorylation by H(2)O(2). Colforsin 60-69 mitogen-activated protein kinase kinase 1 Homo sapiens 164-170 11532475-10 2001 Northern analysis revealed a significant decrease in the expression of CYP17 mRNA in forskolin-stimulated cells treated with metformin (200 microM) compared with forskolin-only-treated cells, however, there was no significant change in steroidogenic acute regulatory protein mRNA expression. Colforsin 85-94 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 71-76 11532475-10 2001 Northern analysis revealed a significant decrease in the expression of CYP17 mRNA in forskolin-stimulated cells treated with metformin (200 microM) compared with forskolin-only-treated cells, however, there was no significant change in steroidogenic acute regulatory protein mRNA expression. Colforsin 162-171 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 71-76 11514346-6 2001 Treatment with forskolin and (Bu)(2) cAMP led to a time- and dose-dependent increase in leptin release, significant after 48 and 72 h. Moreover, incubation with forskolin for 48 h also clearly increased leptin mRNA concentration. Colforsin 15-24 leptin Homo sapiens 88-94 11514346-6 2001 Treatment with forskolin and (Bu)(2) cAMP led to a time- and dose-dependent increase in leptin release, significant after 48 and 72 h. Moreover, incubation with forskolin for 48 h also clearly increased leptin mRNA concentration. Colforsin 15-24 leptin Homo sapiens 203-209 11514346-6 2001 Treatment with forskolin and (Bu)(2) cAMP led to a time- and dose-dependent increase in leptin release, significant after 48 and 72 h. Moreover, incubation with forskolin for 48 h also clearly increased leptin mRNA concentration. Colforsin 161-170 leptin Homo sapiens 88-94 11514346-6 2001 Treatment with forskolin and (Bu)(2) cAMP led to a time- and dose-dependent increase in leptin release, significant after 48 and 72 h. Moreover, incubation with forskolin for 48 h also clearly increased leptin mRNA concentration. Colforsin 161-170 leptin Homo sapiens 203-209 11532475-8 2001 Western blot analysis revealed that metformin significantly inhibited the expression of steroidogenic acute regulatory (StAR) protein and 17 alpha-hydroxylase (CYP17) expression in cells stimulated with forskolin compared with forskolin treatment alone. Colforsin 203-212 steroidogenic acute regulatory protein Homo sapiens 88-118 11532475-8 2001 Western blot analysis revealed that metformin significantly inhibited the expression of steroidogenic acute regulatory (StAR) protein and 17 alpha-hydroxylase (CYP17) expression in cells stimulated with forskolin compared with forskolin treatment alone. Colforsin 203-212 steroidogenic acute regulatory protein Homo sapiens 120-124 11532475-8 2001 Western blot analysis revealed that metformin significantly inhibited the expression of steroidogenic acute regulatory (StAR) protein and 17 alpha-hydroxylase (CYP17) expression in cells stimulated with forskolin compared with forskolin treatment alone. Colforsin 203-212 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 160-165 11532475-8 2001 Western blot analysis revealed that metformin significantly inhibited the expression of steroidogenic acute regulatory (StAR) protein and 17 alpha-hydroxylase (CYP17) expression in cells stimulated with forskolin compared with forskolin treatment alone. Colforsin 227-236 steroidogenic acute regulatory protein Homo sapiens 88-118 11514360-5 2001 TNF downregulates the expression of TbetaR II of insulin/forskolin-stimulated and of unstimulated cells. Colforsin 57-66 insulin Sus scrofa 49-56 11514360-6 2001 The progesterone receptor is also downregulated by the cytokine after insulin/forskolin-induced luteinization. Colforsin 78-87 progesterone receptor Sus scrofa 4-25 11509549-0 2001 Selected contribution: HSP20 phosphorylation in nitroglycerin- and forskolin-induced sustained reductions in swine carotid media tone. Colforsin 67-76 HSPB6 Sus scrofa 23-28 11514360-6 2001 The progesterone receptor is also downregulated by the cytokine after insulin/forskolin-induced luteinization. Colforsin 78-87 insulin Sus scrofa 70-77 11509549-7 2001 Forskolin, which increases cAMP concentration, also induced a sustained inhibitory response that was associated with increases in Ser(16)-HSP20 phosphorylation without reductions in MRLC phosphorylation levels. Colforsin 0-9 HSPB6 Sus scrofa 138-143 11524243-7 2001 Cholera toxin, an activator of G(s), and forskolin, an activator of adenylate cyclase, induced VEGF synthesis. Colforsin 41-50 vascular endothelial growth factor A Mus musculus 95-99 11509549-8 2001 Forskolin increased Ser(16)-HSP20 phosphorylation to a greater extent and inhibited force more completely than that observed with nitroglycerin. Colforsin 0-9 HSPB6 Sus scrofa 28-33 11524243-8 2001 SB203580 and PD169316, another specific inhibitor of p38 MAP kinase, reduced the cholera toxin-, forskolin- or 8bromo-cAMP-stimulated VEGF synthesis. Colforsin 97-106 mitogen-activated protein kinase 14 Mus musculus 53-56 11524243-8 2001 SB203580 and PD169316, another specific inhibitor of p38 MAP kinase, reduced the cholera toxin-, forskolin- or 8bromo-cAMP-stimulated VEGF synthesis. Colforsin 97-106 vascular endothelial growth factor A Mus musculus 134-138 11524243-10 2001 SB203580 reduced the phosphorylation of p38 MAP kinase induced by forskolin or 8bromo-cAMP. Colforsin 66-75 mitogen-activated protein kinase 14 Mus musculus 40-43 11553671-3 2001 Pharmacologically increasing intracellular cAMP levels in cultured cortical astroglia by treatment with dbcAMP or forskolin attenuated FGF-2-induced ERK phosphorylation and glial cell proliferation. Colforsin 114-123 fibroblast growth factor 2 Homo sapiens 135-140 11553671-3 2001 Pharmacologically increasing intracellular cAMP levels in cultured cortical astroglia by treatment with dbcAMP or forskolin attenuated FGF-2-induced ERK phosphorylation and glial cell proliferation. Colforsin 114-123 mitogen-activated protein kinase 1 Homo sapiens 149-152 11502885-5 2001 We have identified several NPY analogs that bind the NPY Y(1) receptor with high affinity and exhibit full agonist activity, measured as inhibition of forskolin-stimulated cAMP production in cells expressing the cloned NPY Y(1) receptor. Colforsin 151-160 neuropeptide Y Rattus norvegicus 27-30 11579131-6 2001 Conversely, overexpression of active GSK3 beta to 3.5-fold the normal levels completely blocked increases in CREB DNA binding activity induced by epidermal growth factor, insulin-like growth factor-1, forskolin, and cyclic AMP. Colforsin 201-210 glycogen synthase kinase 3 beta Homo sapiens 37-46 11579131-6 2001 Conversely, overexpression of active GSK3 beta to 3.5-fold the normal levels completely blocked increases in CREB DNA binding activity induced by epidermal growth factor, insulin-like growth factor-1, forskolin, and cyclic AMP. Colforsin 201-210 cAMP responsive element binding protein 1 Homo sapiens 109-113 11514056-5 2001 Progesterone inhibited forskolin-induced transcriptional activation of hCGalpha gene. Colforsin 23-32 chromogranin A Homo sapiens 71-79 11514056-8 2001 Although progesterone did not alter the amount of CRE-binding protein (CREB), which is a main transcriptional factor bound to CRE(s) on hCGalpha promoter, progesterone abolished forskolin-induced CREB phosphorylation. Colforsin 178-187 cAMP responsive element binding protein 1 Homo sapiens 50-69 11579146-5 2001 Mutation of the CRE in chimeric constructs containing 3.6 kb of the 5" flanking sequence of the mouse TH gene or coexpression of a dominant-negative mutant of CREB prevented the stimulation of TH promoter activity by forskolin. Colforsin 217-226 cAMP responsive element binding protein 1 Mus musculus 159-163 11502873-5 2001 HORK3, when transfected in the rat glioma cell subline (C6-15), responded to 2-methylthio-ADP (2MeSADP) (EC(50) = 0.08 nM) and ADP (EC(50) = 42 nM) with inhibition of forskolin-stimulated cAMP accumulation. Colforsin 167-176 purinergic receptor P2Y12 Homo sapiens 0-5 11514056-8 2001 Although progesterone did not alter the amount of CRE-binding protein (CREB), which is a main transcriptional factor bound to CRE(s) on hCGalpha promoter, progesterone abolished forskolin-induced CREB phosphorylation. Colforsin 178-187 cAMP responsive element binding protein 1 Homo sapiens 71-75 11514056-8 2001 Although progesterone did not alter the amount of CRE-binding protein (CREB), which is a main transcriptional factor bound to CRE(s) on hCGalpha promoter, progesterone abolished forskolin-induced CREB phosphorylation. Colforsin 178-187 chromogranin A Homo sapiens 136-144 11514056-8 2001 Although progesterone did not alter the amount of CRE-binding protein (CREB), which is a main transcriptional factor bound to CRE(s) on hCGalpha promoter, progesterone abolished forskolin-induced CREB phosphorylation. Colforsin 178-187 cAMP responsive element binding protein 1 Homo sapiens 196-200 11502885-5 2001 We have identified several NPY analogs that bind the NPY Y(1) receptor with high affinity and exhibit full agonist activity, measured as inhibition of forskolin-stimulated cAMP production in cells expressing the cloned NPY Y(1) receptor. Colforsin 151-160 neuropeptide Y Rattus norvegicus 53-56 11502885-5 2001 We have identified several NPY analogs that bind the NPY Y(1) receptor with high affinity and exhibit full agonist activity, measured as inhibition of forskolin-stimulated cAMP production in cells expressing the cloned NPY Y(1) receptor. Colforsin 151-160 neuropeptide Y Rattus norvegicus 53-56 11561718-0 2001 Differential effects of forskolin and phobol 12-myristate-13-acetate on the c-fos and c-jun mRNA expression in rat C6 glioma cells. Colforsin 24-33 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 76-81 11447221-8 2001 However, unlike BMP-15, BMP-6 inhibited forskolin- but not 8-bromo-cAMP-induced P(4) production and StAR and P450scc mRNA expression. Colforsin 40-49 bone morphogenetic protein 6 Rattus norvegicus 24-29 11447221-9 2001 BMP-6 also decreased FSH- and forskolin-stimulated cAMP production, suggesting that the underlying mechanism by which BMP-6 inhibits FSH action most likely involves the down-regulation of adenylate cyclase activity. Colforsin 30-39 bone morphogenetic protein 6 Rattus norvegicus 0-5 11447221-9 2001 BMP-6 also decreased FSH- and forskolin-stimulated cAMP production, suggesting that the underlying mechanism by which BMP-6 inhibits FSH action most likely involves the down-regulation of adenylate cyclase activity. Colforsin 30-39 bone morphogenetic protein 6 Rattus norvegicus 118-123 11447221-11 2001 As assumed, BMP-6 did not alter basal FSH-R mRNA levels, whereas it inhibited FSH- and forskolin- but not 8-bromo-cAMP-induced FSH-R mRNA accumulation. Colforsin 87-96 bone morphogenetic protein 6 Rattus norvegicus 12-17 11520498-1 2001 Previous studies from this laboratory have demonstrated that fibroblast growth factor 1 together with a number of co-activator molecules (dopamine, TPA, IBMX/forskolin), will induce the expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in 10% of human neurons (hNTs) derived from the NT2 cell line [10]. Colforsin 158-167 fibroblast growth factor 1 Homo sapiens 61-87 11520498-1 2001 Previous studies from this laboratory have demonstrated that fibroblast growth factor 1 together with a number of co-activator molecules (dopamine, TPA, IBMX/forskolin), will induce the expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in 10% of human neurons (hNTs) derived from the NT2 cell line [10]. Colforsin 158-167 tyrosine hydroxylase Homo sapiens 238-258 11520498-1 2001 Previous studies from this laboratory have demonstrated that fibroblast growth factor 1 together with a number of co-activator molecules (dopamine, TPA, IBMX/forskolin), will induce the expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in 10% of human neurons (hNTs) derived from the NT2 cell line [10]. Colforsin 158-167 tyrosine hydroxylase Homo sapiens 260-262 11561718-1 2001 The effects of forskolin (FSK) and phobol 12-myristate-13-acetate (PMA) on c-fos and c-jun mRNA expressions in rat C6 glioma cells were studied. Colforsin 26-29 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 75-80 11561718-2 2001 Both FSK and PMA increased the c-fos mRNA level. Colforsin 5-8 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 31-36 11561718-4 2001 The elevated c-fos mRNA level, induced by FSK or PMA, was significantly inhibited by dexamethasone (DEX). Colforsin 42-45 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 13-18 11561718-6 2001 Cycloheximide (CHX) caused a superinduction of the FSK- or PMA-induced c-fos mRNA level. Colforsin 51-54 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 71-76 11561718-13 2001 On-going protein synthesis inhibition is required for the superinduction of the c-fos expression that is induced by PMA, or FSK and the PMA-induced c-jun mRNA level. Colforsin 124-127 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 80-85 11526505-7 2001 In contrast, treatment with forskolin, an activator of adenylyl cyclase, led to phosphorylation of CREB and ATF-1 and activation of COX-2 promoter. Colforsin 28-37 cAMP responsive element binding protein 1 Homo sapiens 99-103 11526505-7 2001 In contrast, treatment with forskolin, an activator of adenylyl cyclase, led to phosphorylation of CREB and ATF-1 and activation of COX-2 promoter. Colforsin 28-37 activating transcription factor 1 Homo sapiens 108-113 11526505-7 2001 In contrast, treatment with forskolin, an activator of adenylyl cyclase, led to phosphorylation of CREB and ATF-1 and activation of COX-2 promoter. Colforsin 28-37 mitochondrially encoded cytochrome c oxidase II Homo sapiens 132-137 11494371-7 2001 Pretreatment of N1E-115 cells with a CB1 antisense oligodeoxynucleotide (ODN) suppressed HU-210-induced inhibition of forskolin-stimulated cAMP accumulation, indicating that the knocking down of functional CB1 cannabinoid receptor expression was achieved. Colforsin 118-127 cannabinoid receptor 1 (brain) Mus musculus 37-40 11513835-4 2001 Endothelin-1 failed to stimulate cAMP formation, but it did inhibit forskolin-induced cAMP formation. Colforsin 68-77 endothelin 1 Homo sapiens 0-12 11470465-9 2001 Adrenomedullin partially blocked phenylephrine-mediated transcriptional activation of ANP and MLC-2 reporter gene expression in cardiomyocytes and this effect was mimicked by 2 microM forskolin, suggesting that this response was mediated via the activation of adenylate cyclase. Colforsin 184-193 adrenomedullin Rattus norvegicus 0-14 11466218-13 2001 Forskolin, which potentiated the cAMP response to PDGF-BB, attenuated both DNA synthesis and ERK activation triggered by PDGF-BB, suggesting the presence of a negative feedback regulation. Colforsin 0-9 Eph receptor B1 Rattus norvegicus 93-96 11470465-9 2001 Adrenomedullin partially blocked phenylephrine-mediated transcriptional activation of ANP and MLC-2 reporter gene expression in cardiomyocytes and this effect was mimicked by 2 microM forskolin, suggesting that this response was mediated via the activation of adenylate cyclase. Colforsin 184-193 myosin light chain 2 Rattus norvegicus 94-99 11502794-9 2001 This was substantiated further with the findings that increasing intracellular cAMP using forskolin or (Bu)2cAMP inhibited basal extravillous trophoblast cell migration and blocked IGF-II stimulation of migration. Colforsin 90-99 insulin like growth factor 2 Homo sapiens 181-187 11459779-8 2001 Forskolin-induced activation of ER was enhanced by cotransfection of steroid receptor coactivator-1 and was inhibited by the repressor of ER action, suggesting that cAMP does not alter the normal interactions between ER and cofactors. Colforsin 0-9 nuclear receptor coactivator 1 Homo sapiens 69-99 11469886-8 2001 RESULTS: cAMP-elevating agents inhibited LPS-stimulated TNF-alpha release (0.77 +/- 0.13 ng/10(6) cells in LPS + dbcAMP and 0.68 +/- 0.19 ng/10(6) cells in LPS + FSK, both P < 0.05 vs 1.61 +/- 0.34 ng/10(6) cells in LPS alone). Colforsin 162-165 cathelicidin antimicrobial peptide Homo sapiens 9-13 11454946-4 2001 When human embryonic kidney 293 cells stably expressing the human ORL1 receptor were pre-exposed (30 min) to either OFQ/N or Ro 64-6198, the ability of both agonists to inhibit forskolin-mediated cAMP accumulation was strongly reduced, indicating a functional desensitization of the second messenger cascade. Colforsin 177-186 opioid related nociceptin receptor 1 Homo sapiens 66-70 11469886-9 2001 Conversely, cAMP enhanced LPS-stimulated IL-10 release (100 +/- 21.5 pg/10(6) cells in LPS + dbcAMP and 110 +/- 25.2 pg/10(6) cells in LPS + FSK, both P < 0.05 vs 53.3 +/- 12.8 pg/10(6) cells in LPS alone). Colforsin 141-144 cathelicidin antimicrobial peptide Homo sapiens 12-16 11520896-3 2001 This may be the mechanism by which the adenylyl cyclase activator forskolin inhibits presynaptic mGluR2 function at the medial perforant path-dentate gyrus synapse. Colforsin 66-75 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 97-103 11469886-8 2001 RESULTS: cAMP-elevating agents inhibited LPS-stimulated TNF-alpha release (0.77 +/- 0.13 ng/10(6) cells in LPS + dbcAMP and 0.68 +/- 0.19 ng/10(6) cells in LPS + FSK, both P < 0.05 vs 1.61 +/- 0.34 ng/10(6) cells in LPS alone). Colforsin 162-165 tumor necrosis factor Homo sapiens 56-65 11455022-6 2001 The evoked synaptic currents increased in response to forskolin in neurons grown on FN substratum. Colforsin 54-63 fibronectin 1 S homeolog Xenopus laevis 84-86 11467975-5 2001 Cells were treated with hCG (10 iu) or with increasing doses of forskolin (0-10 micromol l(-1)) for 24 h. Forskolin increased steady-state concentrations of mRNA for PGHS-2 (> 20-fold) and PGF(2alpha) receptor (> 1000-fold) in a dose-dependent fashion. Colforsin 64-73 prostaglandin-endoperoxide synthase 2 Bos taurus 166-172 11494334-8 2001 Adenylate cyclase activator, forskolin (FSK), significantly increased PSA secretion and gene expression, and potassium, which causes nonspecific depolarization of membranes, augmented gene expression, and secretion of PSA, but did not influence cAMP release. Colforsin 29-38 kallikrein related peptidase 3 Homo sapiens 70-73 11494334-8 2001 Adenylate cyclase activator, forskolin (FSK), significantly increased PSA secretion and gene expression, and potassium, which causes nonspecific depolarization of membranes, augmented gene expression, and secretion of PSA, but did not influence cAMP release. Colforsin 29-38 kallikrein related peptidase 3 Homo sapiens 218-221 11494334-8 2001 Adenylate cyclase activator, forskolin (FSK), significantly increased PSA secretion and gene expression, and potassium, which causes nonspecific depolarization of membranes, augmented gene expression, and secretion of PSA, but did not influence cAMP release. Colforsin 40-43 kallikrein related peptidase 3 Homo sapiens 70-73 11494334-8 2001 Adenylate cyclase activator, forskolin (FSK), significantly increased PSA secretion and gene expression, and potassium, which causes nonspecific depolarization of membranes, augmented gene expression, and secretion of PSA, but did not influence cAMP release. Colforsin 40-43 kallikrein related peptidase 3 Homo sapiens 218-221 11467975-5 2001 Cells were treated with hCG (10 iu) or with increasing doses of forskolin (0-10 micromol l(-1)) for 24 h. Forskolin increased steady-state concentrations of mRNA for PGHS-2 (> 20-fold) and PGF(2alpha) receptor (> 1000-fold) in a dose-dependent fashion. Colforsin 106-115 prostaglandin-endoperoxide synthase 2 Bos taurus 166-172 11467975-5 2001 Cells were treated with hCG (10 iu) or with increasing doses of forskolin (0-10 micromol l(-1)) for 24 h. Forskolin increased steady-state concentrations of mRNA for PGHS-2 (> 20-fold) and PGF(2alpha) receptor (> 1000-fold) in a dose-dependent fashion. Colforsin 106-115 prostaglandin F receptor Bos taurus 192-212 11467975-6 2001 Use of selective protein kinase A inhibitor (H89) reduced both hCG- and forskolin-induced expression of PGF(2alpha) receptor mRNA and PGHS-2 mRNA. Colforsin 72-81 prostaglandin F receptor Bos taurus 104-124 11467975-6 2001 Use of selective protein kinase A inhibitor (H89) reduced both hCG- and forskolin-induced expression of PGF(2alpha) receptor mRNA and PGHS-2 mRNA. Colforsin 72-81 prostaglandin-endoperoxide synthase 2 Bos taurus 134-140 11467975-8 2001 Treatment with PGF(2alpha) (100 nmol l(-1)) reduced forskolin-induced expression of PGF(2alpha) receptor mRNA on days 4, 7 and 10, but not on day 1 of culture (n = 3). Colforsin 52-61 prostaglandin F receptor Bos taurus 84-104 11467975-10 2001 In contrast, PGF(2alpha) significantly increased PGHS-2 mRNA expression in granulosa cells primed with forskolin for 7 or 10 days. Colforsin 103-112 prostaglandin-endoperoxide synthase 2 Bos taurus 49-55 11445280-0 2001 Pairing of forskolin and KCl increases differentiation of immortalized hippocampal neurons in a CREB Serine 133 phosphorylation-dependent and extracellular-regulated protein kinase-independent manner. Colforsin 11-20 cAMP responsive element binding protein 1 Homo sapiens 96-100 11352901-4 2001 14-3-3eta interacted with the recombinant alpha4 subunit alone in tsA 201 cells following activation of cAMP-dependent protein kinase by forskolin. Colforsin 137-146 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Homo sapiens 0-9 11445280-0 2001 Pairing of forskolin and KCl increases differentiation of immortalized hippocampal neurons in a CREB Serine 133 phosphorylation-dependent and extracellular-regulated protein kinase-independent manner. Colforsin 11-20 mitogen-activated protein kinase 1 Homo sapiens 142-180 11445280-2 2001 Using an immortalized hippocampal cell line, HiB5, we have tried a pairing of forskolin with KCl depolarization, which acts as an ERK and CREB kinase activator in hippocampal neurons, to investigate if an activation of ERK and phosphorylation of CREB at the critical regulatory site, serine 133 might be coupled in differentiation. Colforsin 78-87 mitogen-activated protein kinase 1 Homo sapiens 130-133 11467832-0 2001 Forskolin activation of apical Cl- channel and Na+/K+/2Cl- cotransporter via a PTK-dependent pathway in renal epithelium. Colforsin 0-9 protein tyrosine kinase 2 beta Homo sapiens 79-82 11445280-2 2001 Using an immortalized hippocampal cell line, HiB5, we have tried a pairing of forskolin with KCl depolarization, which acts as an ERK and CREB kinase activator in hippocampal neurons, to investigate if an activation of ERK and phosphorylation of CREB at the critical regulatory site, serine 133 might be coupled in differentiation. Colforsin 78-87 cAMP responsive element binding protein 1 Homo sapiens 138-142 11444827-4 2001 We showed that forskolin + IBMX inhibited serum-induced ERK activities, Rb hyperphosphorylation, Cdk2 activity, and p27(Kip1) downregulation and caused G1 arrest in MIA PaCa-2 cells. Colforsin 15-24 mitogen-activated protein kinase 1 Homo sapiens 56-59 11467832-4 2001 Tyrphostin A23 abolished the forskolin-induced transepithelial Cl- secretion by partially diminishing the activity of the Cl- channel and completely inhibiting the Na+/K+/2Cl- cotransporter. Colforsin 29-38 immunoglobulin kappa variable 2-24 Homo sapiens 11-14 11467832-5 2001 Further, forskolin increased phosphorylation of protein tyrosine, suggesting that cAMP activates PTK. Colforsin 9-18 protein tyrosine kinase 2 beta Homo sapiens 97-100 11476896-5 2001 Stimulation for 24 h by TSH, forskolin or dibutyryl cAMP induced an increase in mRNA levels of PDE4B, PDE4D, and PDE4C. Colforsin 29-38 phosphodiesterase 4B Rattus norvegicus 95-100 11476896-5 2001 Stimulation for 24 h by TSH, forskolin or dibutyryl cAMP induced an increase in mRNA levels of PDE4B, PDE4D, and PDE4C. Colforsin 29-38 phosphodiesterase 4D Rattus norvegicus 102-107 11476896-5 2001 Stimulation for 24 h by TSH, forskolin or dibutyryl cAMP induced an increase in mRNA levels of PDE4B, PDE4D, and PDE4C. Colforsin 29-38 phosphodiesterase 4C Rattus norvegicus 113-118 11369767-4 2001 Isoproterenol and forskolin mimicked the effect of CL on p38 MAPK. Colforsin 18-27 mitogen-activated protein kinase 14 Homo sapiens 57-65 11369767-7 2001 Treatment of primary brown adipocytes with CL or forskolin induced the expression of UCP1 mRNA levels (6.8- +/- 0.8-fold), and this response was eliminated by PKA inhibitors and SB202190. Colforsin 49-58 uncoupling protein 1 Homo sapiens 85-89 11369767-8 2001 A similar stimulation of a 3.7-kilobase UCP1 promoter by CL and forskolin was also completely inhibited by PKA inhibitors and SB202190, indicating that these effects on UCP1 expression are transcriptional. Colforsin 64-73 uncoupling protein 1 Homo sapiens 40-44 11369767-8 2001 A similar stimulation of a 3.7-kilobase UCP1 promoter by CL and forskolin was also completely inhibited by PKA inhibitors and SB202190, indicating that these effects on UCP1 expression are transcriptional. Colforsin 64-73 uncoupling protein 1 Homo sapiens 169-173 11444827-4 2001 We showed that forskolin + IBMX inhibited serum-induced ERK activities, Rb hyperphosphorylation, Cdk2 activity, and p27(Kip1) downregulation and caused G1 arrest in MIA PaCa-2 cells. Colforsin 15-24 cyclin dependent kinase 2 Homo sapiens 97-101 11444827-4 2001 We showed that forskolin + IBMX inhibited serum-induced ERK activities, Rb hyperphosphorylation, Cdk2 activity, and p27(Kip1) downregulation and caused G1 arrest in MIA PaCa-2 cells. Colforsin 15-24 dynactin subunit 6 Homo sapiens 116-119 11444827-4 2001 We showed that forskolin + IBMX inhibited serum-induced ERK activities, Rb hyperphosphorylation, Cdk2 activity, and p27(Kip1) downregulation and caused G1 arrest in MIA PaCa-2 cells. Colforsin 15-24 cyclin dependent kinase inhibitor 1B Homo sapiens 120-124 11444827-5 2001 Furthermore, forskolin + IBMX protected pancreatic cells against apoptosis induced by prolonged inhibition of ERK activities by preventing Bcl-X(L) downregulation, activation of caspases 3, 6, 8, and 9, and PARP cleavage and by inducing Bad phosphorylation (ser112). Colforsin 13-22 mitogen-activated protein kinase 1 Homo sapiens 110-113 11444827-5 2001 Furthermore, forskolin + IBMX protected pancreatic cells against apoptosis induced by prolonged inhibition of ERK activities by preventing Bcl-X(L) downregulation, activation of caspases 3, 6, 8, and 9, and PARP cleavage and by inducing Bad phosphorylation (ser112). Colforsin 13-22 collagen type XI alpha 2 chain Homo sapiens 207-211 11548900-8 2001 Addition of cAMP (10(-10) to 10(-5) M) caused a significant (P < 0.01) increase in CBF, whereas depletion of endogenous cAMP after pre-incubation with the adenylate cyclase activator forskolin (10(-5) M) prevented the PGE2-induced increase in CBF (P > 0.05). Colforsin 186-195 cathelicidin antimicrobial peptide Homo sapiens 12-16 11346659-1 2001 Forskolin and 8-bromoguanosine 3"-5"-cyclic monophosphate (8-Br-cGMP) induce phosphorylation of Ser-13 of telokin and relaxation of smooth muscle at constant calcium. Colforsin 0-9 myosin light chain kinase Homo sapiens 106-113 11476937-1 2001 Transient transfection of mouse gonadotrope-derived (alphaT3-1) cells with a 2297 bp human GnRHR promoter-luciferase construct (p2300-LucF) showed a dose- and time-dependent increase in the human gonodotropin-releasing hormone receptor (GnRHR) promoter activity after forskolin treatment. Colforsin 268-277 gonadotropin releasing hormone receptor Homo sapiens 91-96 11476937-4 2001 A specific adenylate cyclase (AC) inhibitor (ACI) or protein kinase A (PKA) inhibitor (PKAI) pretreatment reversed the forskolin- and PACAP-induced increase in the human GnRHR promoter activity. Colforsin 119-128 gonadotropin releasing hormone receptor Homo sapiens 170-175 11476937-8 2001 Mutation of the putative hGR-AP/CRE-1 and hGR-CRE-2 resulted in a 38 and 32% decrease in the forskolin-induced stimulation. Colforsin 93-102 GRB2 related adaptor protein Homo sapiens 25-31 11493567-7 2001 Similarly, treatment with PKA activators forskolin and Sp-cAMPs resulted in both reversed heart looping and bilateral expression of NODAL: Ectopic activin induced PKIalpha on the left side of the node, while ectopic Shh and anti-Shh antibody had no effect on PKIalpha expression. Colforsin 41-50 protein kinase (cAMP-dependent, catalytic) inhibitor alpha Gallus gallus 163-171 11493567-7 2001 Similarly, treatment with PKA activators forskolin and Sp-cAMPs resulted in both reversed heart looping and bilateral expression of NODAL: Ectopic activin induced PKIalpha on the left side of the node, while ectopic Shh and anti-Shh antibody had no effect on PKIalpha expression. Colforsin 41-50 sonic hedgehog Gallus gallus 216-219 11493567-7 2001 Similarly, treatment with PKA activators forskolin and Sp-cAMPs resulted in both reversed heart looping and bilateral expression of NODAL: Ectopic activin induced PKIalpha on the left side of the node, while ectopic Shh and anti-Shh antibody had no effect on PKIalpha expression. Colforsin 41-50 sonic hedgehog Gallus gallus 229-232 11493567-7 2001 Similarly, treatment with PKA activators forskolin and Sp-cAMPs resulted in both reversed heart looping and bilateral expression of NODAL: Ectopic activin induced PKIalpha on the left side of the node, while ectopic Shh and anti-Shh antibody had no effect on PKIalpha expression. Colforsin 41-50 protein kinase (cAMP-dependent, catalytic) inhibitor alpha Gallus gallus 259-267 11548900-8 2001 Addition of cAMP (10(-10) to 10(-5) M) caused a significant (P < 0.01) increase in CBF, whereas depletion of endogenous cAMP after pre-incubation with the adenylate cyclase activator forskolin (10(-5) M) prevented the PGE2-induced increase in CBF (P > 0.05). Colforsin 186-195 cathelicidin antimicrobial peptide Homo sapiens 123-127 11431159-3 2001 Furthermore, it was found that secretion of adrenomedullin is regulated by angiotensin II and forskolin. Colforsin 94-103 adrenomedullin Homo sapiens 44-58 11875267-7 2001 Although forskolin stimulation decreased cell volume only in normal, not in CFTR (-/-) crypts, it activated NBC and NKCC to a similar degree in both normal and CFTR (-/-) crypts. Colforsin 9-18 solute carrier family 4 (anion exchanger), member 4 Mus musculus 108-111 11875263-8 2001 Using these values for the R(bl) and the F(Rap) value of 0.08 yields a R(ap) of approximately 14 ohm cm(2) in the presence of forskolin and 4 ohm cm(2) in the presence of forskolin plus 1-EBIO. Colforsin 126-135 LDL receptor related protein associated protein 1 Homo sapiens 43-46 11451139-6 2001 Forskolin potentiated CCK-induced amylase release and this effect was blocked by octreotide treatment; although CCK-8 (3 x 10(-11) M) failed to stimulate cAMP formation, octreotide significantly inhibited basal cAMP formation in the acini. Colforsin 0-9 cholecystokinin Rattus norvegicus 22-25 11875263-8 2001 Using these values for the R(bl) and the F(Rap) value of 0.08 yields a R(ap) of approximately 14 ohm cm(2) in the presence of forskolin and 4 ohm cm(2) in the presence of forskolin plus 1-EBIO. Colforsin 171-180 LDL receptor related protein associated protein 1 Homo sapiens 43-46 11408599-8 2001 The effect of PACAP on SgII mRNA levels, like the effect of the PKC stimulator 12-O-tetradecanoylphorbol-13-acetate (TPA), was not affected by cycloheximide, whereas the effects of the PKA stimulator forskolin or cell-depolarization by high K(+) were significantly reduced by the protein synthesis inhibitor. Colforsin 200-209 secretogranin II Bos taurus 23-27 11434927-7 2001 Thus, both cholera toxin and forskolin decreased resistin mRNA expression in a dose-dependent fashion by up to 90% of control levels. Colforsin 29-38 resistin Homo sapiens 49-57 11406321-4 2001 Administration of FSK increased the expression of CNTFRalpha while lowering the levels of CNTF. Colforsin 18-21 ciliary neurotrophic factor receptor Rattus norvegicus 50-60 11406321-4 2001 Administration of FSK increased the expression of CNTFRalpha while lowering the levels of CNTF. Colforsin 18-21 ciliary neurotrophic factor Rattus norvegicus 50-54 11440542-5 2001 Treatment of BeWo cells with forskolin (FSK) for 48-72 h resulted in an 11- to 44-fold increase in the level of hCG secretion and induced cell fusion leading to the formation of multinucleated syncytiotrophoblasts, indicating functional and morphological differentiation. Colforsin 29-38 hypertrichosis 2 (generalised, congenital) Homo sapiens 112-115 11440542-5 2001 Treatment of BeWo cells with forskolin (FSK) for 48-72 h resulted in an 11- to 44-fold increase in the level of hCG secretion and induced cell fusion leading to the formation of multinucleated syncytiotrophoblasts, indicating functional and morphological differentiation. Colforsin 40-43 hypertrichosis 2 (generalised, congenital) Homo sapiens 112-115 11440542-6 2001 Fluorescence-activated cell sorting (FACS) analysis revealed that treatment with FSK significantly increased the cell-surface protein expression of NEP on differentiating BeWo cells. Colforsin 81-84 membrane metalloendopeptidase Homo sapiens 148-151 11440542-7 2001 Consistently, there was a significant increase in the NEP enzymatic activity after FSK treatment. Colforsin 83-86 membrane metalloendopeptidase Homo sapiens 54-57 11440542-8 2001 The level of hCG secretion from the FSK-treated cells was further enhanced when the cells were treated in the presence of the NEP inhibitor phosphoramidon. Colforsin 36-39 hypertrichosis 2 (generalised, congenital) Homo sapiens 13-16 11440542-8 2001 The level of hCG secretion from the FSK-treated cells was further enhanced when the cells were treated in the presence of the NEP inhibitor phosphoramidon. Colforsin 36-39 membrane metalloendopeptidase Homo sapiens 126-129 11313340-6 2001 Studies of cAMP regulation indicate that treatment with forskolin, dibutyryl cAMP, isobutylmethylxanthine, or isoproterenol activate cellular hAANAT within intact 1E7 cells approximately 8-fold without markedly increasing the abundance of AANAT protein or the activity of AANAT in broken cell preparations; and, that forskolin, isobutylmethylxanthine and isoproterenol elevate cyclic AMP production. Colforsin 56-65 aralkylamine N-acetyltransferase Homo sapiens 142-148 11313340-6 2001 Studies of cAMP regulation indicate that treatment with forskolin, dibutyryl cAMP, isobutylmethylxanthine, or isoproterenol activate cellular hAANAT within intact 1E7 cells approximately 8-fold without markedly increasing the abundance of AANAT protein or the activity of AANAT in broken cell preparations; and, that forskolin, isobutylmethylxanthine and isoproterenol elevate cyclic AMP production. Colforsin 56-65 arylalkylamine N-acetyltransferase Mus musculus 143-148 11313340-6 2001 Studies of cAMP regulation indicate that treatment with forskolin, dibutyryl cAMP, isobutylmethylxanthine, or isoproterenol activate cellular hAANAT within intact 1E7 cells approximately 8-fold without markedly increasing the abundance of AANAT protein or the activity of AANAT in broken cell preparations; and, that forskolin, isobutylmethylxanthine and isoproterenol elevate cyclic AMP production. Colforsin 56-65 arylalkylamine N-acetyltransferase Mus musculus 239-244 11516507-7 2001 Activity was evaluated by measurements of the inhibition of forskolin-stimulated 3",5"-cyclic adenosine monophosphate (c-AMP) performing competitive binding assays. Colforsin 60-69 cathelicidin antimicrobial peptide Homo sapiens 119-124 11390975-6 2001 Moreover, the A1R/P2Y1R coexpressed cells showed an ADPbetaS-dependent reduction of forskolin-evoked cAMP accumulation that was sensitive to pertussis toxin and A1R antagonist, indicating that ADPbetaS binds A1R and inhibits adenylyl cyclase activity via G(i/o) proteins. Colforsin 84-93 purinergic receptor P2Y1 Homo sapiens 18-23 11397723-5 2001 Because the expression of TF and PAI-1 mRNA induced by Ang II was attenuated by the increase of intracellular concentrations of cAMP by forskolin and 8-bromo-cAMP and because AM increased the intracellular level of cAMP in rat aortic endothelial cells, it was indicated that the inhibitory effect of AM on the expressions of TF and PAI-1 was mainly mediated by the cAMP-dependent signal transduction. Colforsin 136-145 coagulation factor III, tissue factor Rattus norvegicus 26-28 11350741-4 2001 After PAR2 activation and the addition of amiloride, the forskolin-stimulated increase in I(sc) was also attenuated. Colforsin 57-66 F2R like trypsin receptor 1 Homo sapiens 6-10 11426771-6 2001 Interleukin 1beta, interleukin 6, and interleukin 8 levels after cardiopulmonary bypass were significantly (p < 0.05) lower in the colforsin group. Colforsin 134-143 interleukin 1 beta Homo sapiens 0-17 11426771-6 2001 Interleukin 1beta, interleukin 6, and interleukin 8 levels after cardiopulmonary bypass were significantly (p < 0.05) lower in the colforsin group. Colforsin 134-143 interleukin 6 Homo sapiens 19-32 11426771-6 2001 Interleukin 1beta, interleukin 6, and interleukin 8 levels after cardiopulmonary bypass were significantly (p < 0.05) lower in the colforsin group. Colforsin 134-143 C-X-C motif chemokine ligand 8 Homo sapiens 38-51 11397723-5 2001 Because the expression of TF and PAI-1 mRNA induced by Ang II was attenuated by the increase of intracellular concentrations of cAMP by forskolin and 8-bromo-cAMP and because AM increased the intracellular level of cAMP in rat aortic endothelial cells, it was indicated that the inhibitory effect of AM on the expressions of TF and PAI-1 was mainly mediated by the cAMP-dependent signal transduction. Colforsin 136-145 serpin family E member 1 Rattus norvegicus 33-38 11397723-5 2001 Because the expression of TF and PAI-1 mRNA induced by Ang II was attenuated by the increase of intracellular concentrations of cAMP by forskolin and 8-bromo-cAMP and because AM increased the intracellular level of cAMP in rat aortic endothelial cells, it was indicated that the inhibitory effect of AM on the expressions of TF and PAI-1 was mainly mediated by the cAMP-dependent signal transduction. Colforsin 136-145 angiotensinogen Rattus norvegicus 55-61 11459289-10 2001 In line with the potentiating effect of P2Y2 receptors on forskolin-stimulated [cAMP]i increases, costimulation with forskolin and P2Y2 receptor agonists led to synergistic antiproliferative effects. Colforsin 58-67 purinergic receptor P2Y2 Homo sapiens 40-44 11368781-9 2001 By contrast, cells treated with cAMP or forskolin possessed discernibly higher IkappaBalpha levels. Colforsin 40-49 NFKB inhibitor alpha Homo sapiens 79-91 11368781-10 2001 In addition, we observed that forskolin potentiated and prolonged the IL-1-induced IkappaBalpha mRNA levels, whereas it did not stabilize the IkappaBalpha mRNA message. Colforsin 30-39 interleukin 1 alpha Homo sapiens 70-74 11368781-10 2001 In addition, we observed that forskolin potentiated and prolonged the IL-1-induced IkappaBalpha mRNA levels, whereas it did not stabilize the IkappaBalpha mRNA message. Colforsin 30-39 NFKB inhibitor alpha Homo sapiens 83-95 11356667-7 2001 We next determined the decay rate of the ERbeta mRNA in granulosa cells that were cultured in the presence of DRB and additional hCG, FSK, or TPA for various time periods, by estimating ERbeta mRNA levels, using semiquantitative RT-PCR assays and subsequent linear regression analyses. Colforsin 134-137 estrogen receptor 2 Rattus norvegicus 41-47 11356667-10 2001 Similarly, both FSK and TPA decreased the half-life of the ERbeta mRNA to 3.57 +/- 0.31 h and 4.02 +/- 0.13 h, respectively. Colforsin 16-19 estrogen receptor 2 Rattus norvegicus 59-65 11356667-12 2001 When granulosa cells were cultured in the presence of cycloheximide, a protein synthesis inhibitor, the inhibitory effects of hCG, FSK, and TPA on ERbeta mRNA levels were abolished. Colforsin 131-134 estrogen receptor 2 Rattus norvegicus 147-153 11368781-1 2001 We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony-stimulating factor (M-CSF) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression. Colforsin 252-261 interleukin 1 alpha Homo sapiens 31-49 11368781-1 2001 We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony-stimulating factor (M-CSF) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression. Colforsin 252-261 interleukin 1 alpha Homo sapiens 51-60 11368781-1 2001 We have recently reported that interleukin-1alpha (IL-1alpha) can induce human macrophage colony-stimulating factor (M-CSF) expression through nuclear factor kappaB (NF-kappaB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated the NF-kappaB activation as well as M-CSF expression. Colforsin 252-261 colony stimulating factor 1 Homo sapiens 117-122 11356700-7 2001 Considering the sites of action of LIF in inhibiting gonadotropin-stimulated testosterone formation, it was shown that LIF significantly (P < 0.002) reduced, in a comparable range (about 60% decrease), testosterone synthesis stimulated with LH/hCG or with pharmacological agents that enhance cAMP levels (cholera toxin, forskolin, and PG E2), and testosterone synthesis stimulated with 8-bromo-cAMP. Colforsin 323-332 LIF interleukin 6 family cytokine Homo sapiens 119-122 11459289-10 2001 In line with the potentiating effect of P2Y2 receptors on forskolin-stimulated [cAMP]i increases, costimulation with forskolin and P2Y2 receptor agonists led to synergistic antiproliferative effects. Colforsin 58-67 purinergic receptor P2Y2 Homo sapiens 131-135 11459289-10 2001 In line with the potentiating effect of P2Y2 receptors on forskolin-stimulated [cAMP]i increases, costimulation with forskolin and P2Y2 receptor agonists led to synergistic antiproliferative effects. Colforsin 117-126 purinergic receptor P2Y2 Homo sapiens 40-44 11413232-6 2001 Although forskolin modulates the phosphorylation of ERKs and Akt, it decreases the susceptibility of iSC to cytokines via a separate mechanism operating after NO induction and before cer accumulation. Colforsin 9-18 AKT serine/threonine kinase 1 Homo sapiens 61-64 11359835-7 2001 Pretreatment of THP-1 cells or mutant THP-1 cells with cAMP analog or forskolin followed by treatment with CKS-17 showed no activation of MEK or ERK1/2. Colforsin 70-79 GLI family zinc finger 2 Homo sapiens 38-43 11469536-6 2001 The cAMP-elevator forskolin did not augment the cytokine-induced elevation of sPLA2-IIa enzyme activity but significantly increased the IL-1beta-stimulated sPLA2-IIa mRNA contents in endothelial cells. Colforsin 18-27 interleukin 1 beta Rattus norvegicus 136-144 11356925-3 2001 In Chinese hamster ovary cells stably expressing the human 5-HT(1A) receptor, 5-HT(1A) receptor-mediated inhibition of forskolin-stimulated cAMP accumulation was reduced by a cyclooxygenase-dependent arachidonic acid (AA) metabolite produced in response to exogenously applied AA or activation of PLA(2) directly with melittin or indirectly by receptor activation. Colforsin 119-128 5-hydroxytryptamine receptor 1A Homo sapiens 59-76 11356925-3 2001 In Chinese hamster ovary cells stably expressing the human 5-HT(1A) receptor, 5-HT(1A) receptor-mediated inhibition of forskolin-stimulated cAMP accumulation was reduced by a cyclooxygenase-dependent arachidonic acid (AA) metabolite produced in response to exogenously applied AA or activation of PLA(2) directly with melittin or indirectly by receptor activation. Colforsin 119-128 5-hydroxytryptamine receptor 1A Homo sapiens 78-95 11356925-3 2001 In Chinese hamster ovary cells stably expressing the human 5-HT(1A) receptor, 5-HT(1A) receptor-mediated inhibition of forskolin-stimulated cAMP accumulation was reduced by a cyclooxygenase-dependent arachidonic acid (AA) metabolite produced in response to exogenously applied AA or activation of PLA(2) directly with melittin or indirectly by receptor activation. Colforsin 119-128 phospholipase A2 group IIA Homo sapiens 297-302 11353815-4 2001 Significantly, forskolin-stimulated CGRP release could be closely correlated with the phosphorylation of the protein kinase A (PKA) substrate cyclic AMP response element-binding protein (CREB). Colforsin 15-24 calcitonin-related polypeptide alpha Rattus norvegicus 36-40 11353815-4 2001 Significantly, forskolin-stimulated CGRP release could be closely correlated with the phosphorylation of the protein kinase A (PKA) substrate cyclic AMP response element-binding protein (CREB). Colforsin 15-24 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 109-125 11353815-4 2001 Significantly, forskolin-stimulated CGRP release could be closely correlated with the phosphorylation of the protein kinase A (PKA) substrate cyclic AMP response element-binding protein (CREB). Colforsin 15-24 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 127-130 11353815-4 2001 Significantly, forskolin-stimulated CGRP release could be closely correlated with the phosphorylation of the protein kinase A (PKA) substrate cyclic AMP response element-binding protein (CREB). Colforsin 15-24 cAMP responsive element binding protein 1 Rattus norvegicus 142-185 11353815-4 2001 Significantly, forskolin-stimulated CGRP release could be closely correlated with the phosphorylation of the protein kinase A (PKA) substrate cyclic AMP response element-binding protein (CREB). Colforsin 15-24 cAMP responsive element binding protein 1 Rattus norvegicus 187-191 11353815-5 2001 Forskolin-stimulated CGRP release could be potently and effectively inhibited by the adenosine A(1) receptor-selective agonist GR79236X (pIC(50) = 7.7 +/- 0.1, maximal inhibition 65 +/- 2.5% at 300 nM), whereas the A(2A) (CGS21680) and the A(3) (2-chloro-N(6)-(3-iodobenzyl)-adenosine-5"-N-methyluronamide) receptor-selective agonists were without effect. Colforsin 0-9 calcitonin-related polypeptide alpha Rattus norvegicus 21-25 11353815-5 2001 Forskolin-stimulated CGRP release could be potently and effectively inhibited by the adenosine A(1) receptor-selective agonist GR79236X (pIC(50) = 7.7 +/- 0.1, maximal inhibition 65 +/- 2.5% at 300 nM), whereas the A(2A) (CGS21680) and the A(3) (2-chloro-N(6)-(3-iodobenzyl)-adenosine-5"-N-methyluronamide) receptor-selective agonists were without effect. Colforsin 0-9 adenosine A1 receptor Rattus norvegicus 85-108 11353815-10 2001 Forskolin-stimulated CGRP release and CREB phosphorylation could be mimicked by incubation of the cells with chlorophenylthio-cAMP and blocked by pretreatment with the PKA inhibitor myrPKI(14-22). Colforsin 0-9 calcitonin-related polypeptide alpha Rattus norvegicus 21-25 11353815-10 2001 Forskolin-stimulated CGRP release and CREB phosphorylation could be mimicked by incubation of the cells with chlorophenylthio-cAMP and blocked by pretreatment with the PKA inhibitor myrPKI(14-22). Colforsin 0-9 cAMP responsive element binding protein 1 Rattus norvegicus 38-42 11353815-10 2001 Forskolin-stimulated CGRP release and CREB phosphorylation could be mimicked by incubation of the cells with chlorophenylthio-cAMP and blocked by pretreatment with the PKA inhibitor myrPKI(14-22). Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 168-171 11353815-11 2001 Taken together, the present data confirm the PKA-dependence of forskolin-stimulated CGRP release and suggest that A(1) adenosine agonists may warrant further investigation in models of migraine and neurogenic inflammation. Colforsin 63-72 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 45-48 11353815-11 2001 Taken together, the present data confirm the PKA-dependence of forskolin-stimulated CGRP release and suggest that A(1) adenosine agonists may warrant further investigation in models of migraine and neurogenic inflammation. Colforsin 63-72 calcitonin-related polypeptide alpha Rattus norvegicus 84-88 11390017-7 2001 Combined treatment with FSK and GHRH antagonist JV-1-38 potentiated the cAMP-inducing effect of FSK, but did not produce a greater inhibition of cell proliferation than JV-1-38 alone. Colforsin 96-99 growth hormone releasing hormone Homo sapiens 32-36 11376117-6 2001 Forskolin, norepinephrine, and dopamine, all of which stimulate cAMP production in GT1 cells, each increased the frequency of Ca(2+) oscillations. Colforsin 0-9 myosin light chain 4 Homo sapiens 83-86 11378162-3 2001 The CB1 agonist desacetyllevonantradol inhibited forskolin-stimulated adenylyl cyclase (18% and 36% maximal inhibition; EC50 = 160 and 73 nM, in rats and monkeys, respectively) and the CB1 antagonist SR141716A (10 microM) completely blocked the maximal inhibition. Colforsin 49-58 cannabinoid receptor 1 Rattus norvegicus 4-7 11378162-3 2001 The CB1 agonist desacetyllevonantradol inhibited forskolin-stimulated adenylyl cyclase (18% and 36% maximal inhibition; EC50 = 160 and 73 nM, in rats and monkeys, respectively) and the CB1 antagonist SR141716A (10 microM) completely blocked the maximal inhibition. Colforsin 49-58 cannabinoid receptor 1 Rattus norvegicus 185-188 11342660-10 2001 Forskolin, CTP-cAMP, and PGE(2) also enhanced LPS- and IFN-induced A8 mRNA, whereas indomethacin significantly reduced synergy between IL-10 and LPS. Colforsin 0-9 toll-like receptor 4 Mus musculus 46-69 11290527-3 2001 PGE(2) and forskolin inhibited mitogen-induced ERK activation. Colforsin 11-20 mitogen-activated protein kinase 1 Homo sapiens 47-50 11369453-6 2001 Following PACAP-27, PACAP-38 (30 nM) and forskolin (25 microM) treatment, there were significant increases in the reporter gene activities. Colforsin 41-50 adenylate cyclase activating polypeptide 1 Homo sapiens 10-15 11437736-7 2001 Prolactin and LPS treatment in vivo reduced the progesterone response to follicle stimulating hormone (FSH) (P < 0.001) in cultures of ovarian dispersates but did not inhibit the response to forskolin. Colforsin 194-203 prolactin Rattus norvegicus 0-9 11437736-8 2001 In contrast, prolactin or LPS added in vitro to the cultures inhibited the progesterone response to forskolin. Colforsin 100-109 prolactin Rattus norvegicus 13-22 11348877-6 2001 Forskolin and adrenomedullin also potentiated coronary NO production induced by bradykinin. Colforsin 0-9 kininogen 1 Canis lupus familiaris 80-90 11350835-3 2001 Chronic incubation with IL-1beta or RV caused a significant increase (approximately 3- and approximately 2-fold, respectively) in forskolin (FSK)-stimulated cAMP production, suggesting a sensitization of adenylyl cyclase (AC). Colforsin 130-139 interleukin 1 beta Homo sapiens 24-32 11350835-3 2001 Chronic incubation with IL-1beta or RV caused a significant increase (approximately 3- and approximately 2-fold, respectively) in forskolin (FSK)-stimulated cAMP production, suggesting a sensitization of adenylyl cyclase (AC). Colforsin 141-144 interleukin 1 beta Homo sapiens 24-32 11350835-4 2001 The observed augmentation of FSK-stimulated cAMP formation by IL-1beta was completely abrogated by pretreatment with an IL-1 receptor antagonist or cycloheximide, demonstrating that the effect is mediated via the IL-1 receptor 1 (IL-1R1) and that de novo protein synthesis is required. Colforsin 29-32 interleukin 1 beta Homo sapiens 62-70 11350835-4 2001 The observed augmentation of FSK-stimulated cAMP formation by IL-1beta was completely abrogated by pretreatment with an IL-1 receptor antagonist or cycloheximide, demonstrating that the effect is mediated via the IL-1 receptor 1 (IL-1R1) and that de novo protein synthesis is required. Colforsin 29-32 interleukin 1 receptor antagonist Homo sapiens 120-144 11350835-4 2001 The observed augmentation of FSK-stimulated cAMP formation by IL-1beta was completely abrogated by pretreatment with an IL-1 receptor antagonist or cycloheximide, demonstrating that the effect is mediated via the IL-1 receptor 1 (IL-1R1) and that de novo protein synthesis is required. Colforsin 29-32 interleukin 1 receptor type 1 Homo sapiens 213-228 11350835-4 2001 The observed augmentation of FSK-stimulated cAMP formation by IL-1beta was completely abrogated by pretreatment with an IL-1 receptor antagonist or cycloheximide, demonstrating that the effect is mediated via the IL-1 receptor 1 (IL-1R1) and that de novo protein synthesis is required. Colforsin 29-32 interleukin 1 receptor type 1 Homo sapiens 230-236 11325803-17 2001 SQA-NPFF inhibited forskolin induced cyclic AMP accumulation in recombinant CHO cells in a dose dependent manner. Colforsin 19-28 pro-FMRFamide-related neuropeptide FF Cricetulus griseus 4-8 11350858-4 2001 The stimulation of AChE synthesis induced by CGRP was mimicked by direct activation of AC with 3 - 30 microM forskolin. Colforsin 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 11350858-4 2001 The stimulation of AChE synthesis induced by CGRP was mimicked by direct activation of AC with 3 - 30 microM forskolin. Colforsin 109-118 calcitonin related polypeptide alpha Homo sapiens 45-49 11379759-6 2001 Our data show that DBcAMP or forskolin blocked SNAP-induced caspase-3-like cysteine protease activation and that H-89, a PKA inhibitor, reversed the cAMP-induced regulatory effect of caspase-3 like protease. Colforsin 29-38 caspase 3 Homo sapiens 60-69 11369514-4 2001 Forskolin (adenylate cyclase activator) affected more the GHA-induced TNF-alpha release than the phorbol 12-myristate 13-acetate (PMA)-induced one in undifferentiated cells. Colforsin 0-9 tumor necrosis factor Homo sapiens 70-79 11350859-7 2001 This increase in serum TNF-alpha was completely blocked by a pretreatment with pentoxifylline (160 mg kg-1), milrinone (5 mg kg-1), rolipram (1 mg kg-1), zaprinast (10 mg kg-1), salbutamol (0.5 mg kg-1), forskolin (1 mg kg-1) and 8-Br-cAMP (10 mg kg-1). Colforsin 204-213 tumor necrosis factor Mus musculus 23-32 11432722-2 2001 In the present study, we examined the effect of parathyroid hormone (PTH), dibutyryl cAMP (Bt2cAMP) and forskolin on the expression of DEC1 in various cells. Colforsin 104-113 deleted in esophageal cancer 1 Homo sapiens 135-139 11316746-7 2001 Furthermore, forskolin, (which stimulates adenylyl cyclase and insulin secretion), and 8-Bromo-cAMP, (an analog of cAMP which also stimulates insulin secretion), mimicked the effects of GLP-1 on PDX-1. Colforsin 13-22 glucagon Rattus norvegicus 186-191 11316751-4 2001 Time course and efficacy of transcription and translation blockade were assessed by determining the ability of specific inhibitors to block the robust, rapid induction of c-fos mRNA or protein accumulation by forskolin (10 microM). Colforsin 209-218 FBJ osteosarcoma oncogene Mus musculus 171-176 11417226-7 2001 CFTR currents were evoked by application of a forskolin/3-isobutyl-l-methylxanthine (IBMX) cocktail. Colforsin 46-55 CF transmembrane conductance regulator Bos taurus 0-4 11312556-2 2001 The novel expression of TH in these cells is signaled by the synergistic interaction of factors present in the media, such as fibroblast growth factor 1 (FGF1) and one of several possible coactivators [DA, phorbol 12-myristate 13-acetate (TPA), isobutylmethylxanthine (IBMX), or forskolin]. Colforsin 279-288 tyrosine hydroxylase Homo sapiens 24-26 11312556-2 2001 The novel expression of TH in these cells is signaled by the synergistic interaction of factors present in the media, such as fibroblast growth factor 1 (FGF1) and one of several possible coactivators [DA, phorbol 12-myristate 13-acetate (TPA), isobutylmethylxanthine (IBMX), or forskolin]. Colforsin 279-288 fibroblast growth factor 1 Homo sapiens 126-152 11359874-3 2001 Stimulation of this receptor by the apelin fragments K17F (Lys1-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe17) and pE13F (pGlu5-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe17) resulted in a dose-dependent inhibition of forskolin-induced cAMP production and promoted its internalization. Colforsin 242-251 apelin Rattus norvegicus 36-42 11328856-8 2001 The observed effect of FSH on MMP-23 expression was mimicked by treatment of granulosa cells with forskolin or 8-bromo (Br)-cAMP. Colforsin 98-107 matrix metallopeptidase 23 Rattus norvegicus 30-36 11328856-10 2001 However, treatment of theca-interstitial cells with forskolin or 8-Br-cAMP markedly reduced the expression of MMP-23 with a concomitant increase in progesterone production. Colforsin 52-61 matrix metallopeptidase 23 Rattus norvegicus 110-116 11319768-8 2001 These changes may be mediated by the cAMP or PKC pathways because both forskolin and TPA up-regulated the GFR alpha-1 gene. Colforsin 71-80 GDNF family receptor alpha 1 Rattus norvegicus 106-117 11360001-4 2001 B-20991 was found to antagonize the forskolin-induced increase of cAMP synthesis in a HeLa cell line transfected with the human 5-HT1A in a process sensitive to the selective blocker N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide maleate (WAY 100635). Colforsin 36-45 5-hydroxytryptamine receptor 1A Homo sapiens 128-134 11278733-2 2001 In this study, 57 analogues of MCH were investigated on the recently cloned human MCH receptor stably expressed in HEK293 cells, on both the inhibition of forskolin-stimulated cAMP production and guanosine-5"-O-(3-[(35)S]thiotriphosphate ([(35)S]- GTPgammaS) binding. Colforsin 155-164 pro-melanin concentrating hormone Homo sapiens 31-34 11334998-1 2001 Brain-derived neurotrophic factor (BDNF; 50 ng/ml), dopamine (DA; 10 microM) and forskolin (Fsk; 10 microM) have previously been shown by this and other laboratories to induce the tyrosine hydroxylase (TH) enzyme in foetal human and rat cerebral cortex during specified sensitive developmental periods. Colforsin 81-90 tyrosine hydroxylase Homo sapiens 180-200 11334998-1 2001 Brain-derived neurotrophic factor (BDNF; 50 ng/ml), dopamine (DA; 10 microM) and forskolin (Fsk; 10 microM) have previously been shown by this and other laboratories to induce the tyrosine hydroxylase (TH) enzyme in foetal human and rat cerebral cortex during specified sensitive developmental periods. Colforsin 81-90 tyrosine hydroxylase Homo sapiens 202-204 11334998-1 2001 Brain-derived neurotrophic factor (BDNF; 50 ng/ml), dopamine (DA; 10 microM) and forskolin (Fsk; 10 microM) have previously been shown by this and other laboratories to induce the tyrosine hydroxylase (TH) enzyme in foetal human and rat cerebral cortex during specified sensitive developmental periods. Colforsin 92-95 brain derived neurotrophic factor Homo sapiens 0-33 11334998-1 2001 Brain-derived neurotrophic factor (BDNF; 50 ng/ml), dopamine (DA; 10 microM) and forskolin (Fsk; 10 microM) have previously been shown by this and other laboratories to induce the tyrosine hydroxylase (TH) enzyme in foetal human and rat cerebral cortex during specified sensitive developmental periods. Colforsin 92-95 brain derived neurotrophic factor Homo sapiens 35-39 11334998-1 2001 Brain-derived neurotrophic factor (BDNF; 50 ng/ml), dopamine (DA; 10 microM) and forskolin (Fsk; 10 microM) have previously been shown by this and other laboratories to induce the tyrosine hydroxylase (TH) enzyme in foetal human and rat cerebral cortex during specified sensitive developmental periods. Colforsin 92-95 tyrosine hydroxylase Homo sapiens 180-200 11334998-1 2001 Brain-derived neurotrophic factor (BDNF; 50 ng/ml), dopamine (DA; 10 microM) and forskolin (Fsk; 10 microM) have previously been shown by this and other laboratories to induce the tyrosine hydroxylase (TH) enzyme in foetal human and rat cerebral cortex during specified sensitive developmental periods. Colforsin 92-95 tyrosine hydroxylase Homo sapiens 202-204 11311890-6 2001 The cAMP-elevating agent forskolin could mimic the effects of beta-agonists, indicating that IL-12p40 release inhibition involves intracellular cAMP accumulation. Colforsin 25-34 interleukin 12b Mus musculus 93-101 11278733-2 2001 In this study, 57 analogues of MCH were investigated on the recently cloned human MCH receptor stably expressed in HEK293 cells, on both the inhibition of forskolin-stimulated cAMP production and guanosine-5"-O-(3-[(35)S]thiotriphosphate ([(35)S]- GTPgammaS) binding. Colforsin 155-164 pro-melanin concentrating hormone Homo sapiens 82-85 11299302-3 2001 The inhibitory action of 100 ng/mL Tat approached 50% after 4 h of preincubation and reached a maximum of 70% after 24 h. The Tat-induced time- and dose-dependent decrease of cAMP accumulation was observed also when microglial cultures were stimulated with the adenylyl cyclase activator forskolin (100 microM). Colforsin 288-297 tyrosine aminotransferase Homo sapiens 35-38 11336791-10 2001 As H89 also abolished forskolin-induced UCP1 gene expression, and potentiated selective beta(3)-AR-induced cAMP production, H89 must be active downstream of cAMP. Colforsin 22-31 uncoupling protein 1 Homo sapiens 40-44 11334872-2 2001 In vessels preconstricted with endothelin-1, forskolin at concentrations < or =10(-7) M had no effect on cAMP content and adenylyl cyclase activity but caused up to 50% relaxation. Colforsin 45-54 EDN1 Ovis aries 31-43 11321362-7 2001 Furthermore, dibutyryl cAMP, a cAMP analogue, and forskolin, an adenylate cyclase activator, downregulated A. actinomycetemcomitans-, P. gingivalis- and E. coli-LPS-elicited ICAM-1 expression in HGF. Colforsin 50-59 intercellular adhesion molecule 1 Homo sapiens 174-180 11321362-7 2001 Furthermore, dibutyryl cAMP, a cAMP analogue, and forskolin, an adenylate cyclase activator, downregulated A. actinomycetemcomitans-, P. gingivalis- and E. coli-LPS-elicited ICAM-1 expression in HGF. Colforsin 50-59 hepatocyte growth factor Homo sapiens 195-198 11299302-8 2001 On the contrary, two inhibitors of nuclear factor kappaB activation, N-tosyl-( L)-phenylalanine chloromethyl ketone (10 microM) and SN50 (25 microM), markedly prevented the reduction of forskolin-evoked cAMP accumulation by Tat, suggesting a possible role for this nuclear transcriptional factor in the regulation of adenylyl cyclase by Tat in microglia. Colforsin 186-195 tyrosine aminotransferase Homo sapiens 224-227 11299302-8 2001 On the contrary, two inhibitors of nuclear factor kappaB activation, N-tosyl-( L)-phenylalanine chloromethyl ketone (10 microM) and SN50 (25 microM), markedly prevented the reduction of forskolin-evoked cAMP accumulation by Tat, suggesting a possible role for this nuclear transcriptional factor in the regulation of adenylyl cyclase by Tat in microglia. Colforsin 186-195 tyrosine aminotransferase Homo sapiens 337-340 11311970-4 2001 Furthermore, LPS-induced increases of p-p38, but not activation of NF kappa B, were also reduced by FSK and H89 reversed the FSK-induced inhibition response. Colforsin 125-128 mitogen-activated protein kinase 14 Homo sapiens 40-43 11288140-3 2001 In addition to a robust induction by NGF and FGF, both of which cause PC12 cells to differentiate, NID67 is strongly induced by forskolin, A23187 and ATP. Colforsin 128-137 small integral membrane protein 3 Rattus norvegicus 99-104 11278377-6 2001 Consistent with a role of cAMP and protein kinase A, both prostaglandins induced a marked accumulation of cAMP in human myotubes, and forskolin reproduced the effect of arachidonic acid on UCP-2 mRNA expression. Colforsin 134-143 uncoupling protein 2 Homo sapiens 189-194 11299302-3 2001 The inhibitory action of 100 ng/mL Tat approached 50% after 4 h of preincubation and reached a maximum of 70% after 24 h. The Tat-induced time- and dose-dependent decrease of cAMP accumulation was observed also when microglial cultures were stimulated with the adenylyl cyclase activator forskolin (100 microM). Colforsin 288-297 tyrosine aminotransferase Homo sapiens 126-129 11299302-6 2001 The target of Tat appeared to be adenylyl cyclase, whose activity was markedly reduced (up to 60%) in membranes prepared from Tat-treated microglial cells, both in basal conditions and after stimulation with isoproterenol and forskolin. Colforsin 226-235 tyrosine aminotransferase Homo sapiens 14-17 11299302-6 2001 The target of Tat appeared to be adenylyl cyclase, whose activity was markedly reduced (up to 60%) in membranes prepared from Tat-treated microglial cells, both in basal conditions and after stimulation with isoproterenol and forskolin. Colforsin 226-235 tyrosine aminotransferase Homo sapiens 126-129 11104774-10 2001 ADP was subsequently shown to inhibit forskolin-stimulated adenylyl cyclase activity through selective activation of SP1999 with an EC(50) of 60 nM. Colforsin 38-47 purinergic receptor P2Y12 Homo sapiens 117-123 11259542-3 2001 Using the transcriptional inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, CYP2C11 mRNA was found to have a half-life of 9.8 h. The kinetics of suppression of CYP2C11 mRNA by glucagon and forskolin was similar to that obtained with the transcriptional inhibitor, suggesting that glucagon and forskolin act at the transcriptional level. Colforsin 199-208 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 86-93 11259542-3 2001 Using the transcriptional inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, CYP2C11 mRNA was found to have a half-life of 9.8 h. The kinetics of suppression of CYP2C11 mRNA by glucagon and forskolin was similar to that obtained with the transcriptional inhibitor, suggesting that glucagon and forskolin act at the transcriptional level. Colforsin 303-312 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 86-93 11312608-4 2001 Application of cAMP and forskolin induced the expression of chick AChE but reduced human AChE promoter-driven luciferase activity. Colforsin 24-33 acetylcholinesterase (Cartwright blood group) Gallus gallus 66-70 11312608-4 2001 Application of cAMP and forskolin induced the expression of chick AChE but reduced human AChE promoter-driven luciferase activity. Colforsin 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 11371113-13 2001 A time-course analysis revealed that the GnRH-R mRNA levels were significantly lower up to 9 h after FSH treatment, and returned to the basal level between 12 h-24 h. Activation of adenylate cyclase with forskolin also decreased the GnRH-R mRNA levels. Colforsin 204-213 gonadotropin releasing hormone receptor Rattus norvegicus 41-47 11371113-13 2001 A time-course analysis revealed that the GnRH-R mRNA levels were significantly lower up to 9 h after FSH treatment, and returned to the basal level between 12 h-24 h. Activation of adenylate cyclase with forskolin also decreased the GnRH-R mRNA levels. Colforsin 204-213 gonadotropin releasing hormone receptor Rattus norvegicus 233-239 11290372-4 2001 We also demonstrated that a low dose of Db-cAMP, forskolin or dexamethasone inhibited the production of tumor necrosis factor-alpha and interleukin-1 beta by macrophages stimulated by zymosan. Colforsin 49-58 tumor necrosis factor Mus musculus 104-131 11290372-4 2001 We also demonstrated that a low dose of Db-cAMP, forskolin or dexamethasone inhibited the production of tumor necrosis factor-alpha and interleukin-1 beta by macrophages stimulated by zymosan. Colforsin 49-58 interleukin 1 beta Mus musculus 136-154 11282111-2 2001 In the human intestinal epithelial cell line HT29cl.19A, it has been previously shown that neuropeptide Y inhibits the electrophysiological phenomena related to Cl(-) secretion, when induced by elevation of cAMP via forskolin. Colforsin 216-225 neuropeptide Y Homo sapiens 91-105 11246232-6 2001 In serum-free medium, HRG and FGF-2 were mitogenic, but PDGF-BB, IGF-1 and FSK were not; however, FSK potentiated the stimulation by HRG and FGF-2, and the combination of HRG + FGF-2 promoted EG proliferation in an additive manner. Colforsin 98-101 fibroblast growth factor 2 Rattus norvegicus 30-35 11237861-5 2001 This TSH effect was mimicked by forskolin and thyroid-stimulating antibodies obtained from patients with Graves"s disease, suggesting that an increase in intracellular cAMP is responsible for the induction of different NF-kappaBs by TNF-alpha. Colforsin 32-41 tumor necrosis factor Homo sapiens 233-242 11113152-2 2001 The C1a and C2a domains form a catalytic core that can be stimulated by forskolin and the stimulatory G protein subunit alpha (Galpha(s)). Colforsin 72-81 endogenous retrovirus group K member 1 Homo sapiens 4-7 11113152-6 2001 SlyD protein can inhibit the Galpha(s)- and/or forskolin-activated activity of both soluble and membrane-bound AC7. Colforsin 47-56 adenylate cyclase 7 Homo sapiens 111-114 11246232-6 2001 In serum-free medium, HRG and FGF-2 were mitogenic, but PDGF-BB, IGF-1 and FSK were not; however, FSK potentiated the stimulation by HRG and FGF-2, and the combination of HRG + FGF-2 promoted EG proliferation in an additive manner. Colforsin 98-101 fibroblast growth factor 2 Rattus norvegicus 141-146 11246232-6 2001 In serum-free medium, HRG and FGF-2 were mitogenic, but PDGF-BB, IGF-1 and FSK were not; however, FSK potentiated the stimulation by HRG and FGF-2, and the combination of HRG + FGF-2 promoted EG proliferation in an additive manner. Colforsin 98-101 fibroblast growth factor 2 Rattus norvegicus 141-146 11245858-6 2001 In isolated islets elgodipine (10(-6) M) blocked forskolin (10(-6) M)-induced insulin release. Colforsin 49-58 insulin Oryctolagus cuniculus 78-85 11237748-4 2001 Activation of CFTR by IBMX and forskolin was attenuated in the presence of alphaG(i2), indicating inhibition of CFTR by alphaG(i2) in Xenopus oocytes. Colforsin 31-40 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 14-18 11237748-4 2001 Activation of CFTR by IBMX and forskolin was attenuated in the presence of alphaG(i2), indicating inhibition of CFTR by alphaG(i2) in Xenopus oocytes. Colforsin 31-40 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 112-116 11323002-8 2001 Cilostazol inhibited completely thrombin-induced aggregation in the presence of 1 microM forskolin, when cAMP levels were two-fold higher than those in the absence of forskolin. Colforsin 89-98 coagulation factor II, thrombin Homo sapiens 32-40 11248248-4 2001 Phospho-PYY potently inhibits forskolin-stimulated cAMP accumulation in SK-N-MC cells with an IC(50) value of 0.5 nM compared to 0.15 nM for non-phosphorylated PYY. Colforsin 30-39 peptide YY Homo sapiens 8-11 11237748-5 2001 Coexpression of the proteins RGS3 and RGS7 together with CFTR and alphaG(i2) partially recovered activation by IBMX/forskolin. Colforsin 116-125 regulator of G-protein signaling 3 L homeolog Xenopus laevis 29-33 11237748-5 2001 Coexpression of the proteins RGS3 and RGS7 together with CFTR and alphaG(i2) partially recovered activation by IBMX/forskolin. Colforsin 116-125 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 57-61 11120746-8 2001 IGF-I inhibited both basal and forskolin-stimulated cAMP levels. Colforsin 31-40 insulin like growth factor 1 Homo sapiens 0-5 11248248-4 2001 Phospho-PYY potently inhibits forskolin-stimulated cAMP accumulation in SK-N-MC cells with an IC(50) value of 0.5 nM compared to 0.15 nM for non-phosphorylated PYY. Colforsin 30-39 peptide YY Homo sapiens 160-163 11239505-10 2001 In addition alpha-MSH, alpha-MSH(1-10), alpha-MSH(11-13), and forskolin also inhibited the activity of an NF-kappaB-dependent luciferase reporter and these effects were partially counteracted by H89. Colforsin 62-71 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 106-115 11181520-10 2001 Forskolin had no measurable effect in RAP cells, but increased Smad7 mRNA levels in alpha T3-1 cells and decreased them in L beta T2 cells. Colforsin 0-9 SMAD family member 7 Mus musculus 63-68 11180971-9 2001 Moreover, the expression of TRP-2 mRNA was induced by retinoic acid in retinoblastoma cells but not noticeably affected by forskolin, a cAMP-elevating reagent, whereas in melanoma cells its expression was induced by forskolin but not by retinoic acid. Colforsin 216-225 dopachrome tautomerase Homo sapiens 28-33 11284200-3 2001 The forskolin-induced anion current was sustained and significantly (54%) suppressed by glibenclamide (200 microM), a blocker of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel. Colforsin 4-13 CF transmembrane conductance regulator Rattus norvegicus 133-184 11247980-12 2001 In cells transfected with mGluR3, but not mGluR2, beta-NAAG blocked forskolin-stimulated cAMP responses to glutamate, NAAG, the nonspecific group I, II agonist trans-ACPD, and the group II agonist DCG-IV. Colforsin 68-77 glutamate receptor, ionotropic, AMPA3 (alpha 3) Mus musculus 26-32 11223871-5 2001 Cholesterol and 25-OH cholesterol had no effect, while forskolin exerted a significant inhibitory effect, on apoE secretion in KYN-2 cells. Colforsin 55-64 apolipoprotein E Homo sapiens 109-113 11259503-5 2001 Detailed examination of the forskolin responsiveness of PNMT constructs harboring > or = 60 bp and < 893 bp of PNMT promoter demonstrated that the cAMP-responsive element(s) lay between < 392 bp and > or =60 bp. Colforsin 28-37 phenylethanolamine-N-methyltransferase Rattus norvegicus 56-60 11259503-7 2001 Forskolin treatment of PC12 cells also rapidly increased nuclear levels of Egr-1 and the catalytic subunit of PKA (PKA-C), with the rise in PKA-C preceding that of Egr-1. Colforsin 0-9 early growth response 1 Rattus norvegicus 75-80 11259503-7 2001 Forskolin treatment of PC12 cells also rapidly increased nuclear levels of Egr-1 and the catalytic subunit of PKA (PKA-C), with the rise in PKA-C preceding that of Egr-1. Colforsin 0-9 early growth response 1 Rattus norvegicus 164-169 11284200-3 2001 The forskolin-induced anion current was sustained and significantly (54%) suppressed by glibenclamide (200 microM), a blocker of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel. Colforsin 4-13 CF transmembrane conductance regulator Rattus norvegicus 186-190 11259503-8 2001 Mutation of the --165 bp Egr-1 site markedly decreased forskolin activation of the PNMT promoter. Colforsin 55-64 early growth response 1 Rattus norvegicus 25-30 11249067-5 2001 With high glucose, insulin release was markedly potentiated by forskolin, glucagon, glucagon-like peptide-1, and arginine and inhibited by somatostatin, the Ca2+ channel blocker nitrendipine, and the ATP-sensitive K+ channel opener diazoxide. Colforsin 63-72 insulin Homo sapiens 19-26 11259503-8 2001 Mutation of the --165 bp Egr-1 site markedly decreased forskolin activation of the PNMT promoter. Colforsin 55-64 phenylethanolamine-N-methyltransferase Rattus norvegicus 83-87 28095239-7 2001 However, enhanced Ang II (105+-10%, p<0.001) responses were seen during AC activation by forskolin (0.1-1 microM). Colforsin 92-101 angiotensinogen Homo sapiens 18-24 11181701-6 2001 Both PKA type I and Csk are targeted to lipid rafts where proximal T cell activation occurs, and phosphorylation of raft-associated Lck by Csk is increased in cells treated with forskolin. Colforsin 178-187 C-terminal Src kinase Homo sapiens 20-23 11316265-3 2001 At -20 mV, forskolin (4 microM) induced a fast activation of I(CFTR) and a delayed stimulation of Ip. Colforsin 11-20 cystic fibrosis transmembrane conductance regulator Cavia porcellus 63-67 11316265-5 2001 Half-maximal activation of I(CFTR) and stimulation of Ip, respectively, were observed at 9.6 x 10(-8) M and 9.9 x 10(-8) M forskolin. Colforsin 123-132 cystic fibrosis transmembrane conductance regulator Cavia porcellus 29-33 11316265-7 2001 However, regardless of the time allowed for cell dialysis, there still was a marked, transient activation of I(CFTR), which could be prevented by: (1) a short pre-activation of I(CFTR) with forskolin or (2) the additional inclusion in the pipette solution of a synthetic peptide (Ht31 peptide, 60 microM) that interferes with PKA binding to its anchoring proteins. Colforsin 190-199 cystic fibrosis transmembrane conductance regulator Cavia porcellus 111-115 11316265-7 2001 However, regardless of the time allowed for cell dialysis, there still was a marked, transient activation of I(CFTR), which could be prevented by: (1) a short pre-activation of I(CFTR) with forskolin or (2) the additional inclusion in the pipette solution of a synthetic peptide (Ht31 peptide, 60 microM) that interferes with PKA binding to its anchoring proteins. Colforsin 190-199 cystic fibrosis transmembrane conductance regulator Cavia porcellus 179-183 11287093-1 2001 In HEC-1B cells transfected with human Y(5) neuropeptide Y (NPY) receptors (but not in non-transfected cells) NPY inhibited forskolin-stimulated cAMP accumulation in a pertussis toxin-sensitive manner (-log EC(50) 8.88 +/- 0.25). Colforsin 124-133 neuropeptide Y Homo sapiens 60-63 11287093-1 2001 In HEC-1B cells transfected with human Y(5) neuropeptide Y (NPY) receptors (but not in non-transfected cells) NPY inhibited forskolin-stimulated cAMP accumulation in a pertussis toxin-sensitive manner (-log EC(50) 8.88 +/- 0.25). Colforsin 124-133 neuropeptide Y Homo sapiens 110-113 11181701-6 2001 Both PKA type I and Csk are targeted to lipid rafts where proximal T cell activation occurs, and phosphorylation of raft-associated Lck by Csk is increased in cells treated with forskolin. Colforsin 178-187 LCK proto-oncogene, Src family tyrosine kinase Homo sapiens 132-135 11181701-6 2001 Both PKA type I and Csk are targeted to lipid rafts where proximal T cell activation occurs, and phosphorylation of raft-associated Lck by Csk is increased in cells treated with forskolin. Colforsin 178-187 C-terminal Src kinase Homo sapiens 139-142 11208547-6 2001 After stimulation with forskolin, duct units from NHE3-/- mice fail to absorb the secreted fluid from the cholangiocyte lumen compared with control animals. Colforsin 23-32 solute carrier family 9 (sodium/hydrogen exchanger), member 3 Mus musculus 50-54 11165046-0 2001 GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line. Colforsin 31-40 gonadotropin releasing hormone receptor Rattus norvegicus 0-2 11165046-9 2001 Finally, treatment with 10 microM forskolin, to directly activate adenylate cyclase, increased GH mRNA to 140% of controls in TDM, and to 163% in serum-free medium after 2 days, and to 166% in TDM-treated cells and 174% in serum-free culture after 5 days (all P<0.05). Colforsin 34-43 gonadotropin releasing hormone receptor Rattus norvegicus 95-97 11050094-4 2001 Foscarnet was more potent than PP(i) in suppressing forskolin-stimulated catalysis by both, IC1/IIC2 and VIIC1/IIC2. Colforsin 52-61 ICR1 differentially methylated region Homo sapiens 92-95 11208583-7 2001 H-89 restored the cAMP- and forskolin-inhibited PLA(2) activities. Colforsin 28-37 phospholipase A2 group IB Homo sapiens 48-54 11284466-8 2001 PAF also enhanced the gastrin release stimulated by forskolin and bombesin. Colforsin 52-61 gastrin Oryctolagus cuniculus 22-29 11159837-7 2001 Activation of the PKA and PKC pathways by 10 microM forskolin and 1 microM PMA, respectively, induced Nurr1 mRNA levels. Colforsin 52-61 nuclear receptor subfamily 4, group A, member 2 Mus musculus 102-107 11174853-8 2001 Treatment of transfected cells with dexamethasone resulted in suppression of forskolin- or Nak1-stimulated POMC-reporter gene expression in the presence of co-transfected GR but not with GRDelta. Colforsin 77-86 proopiomelanocortin Homo sapiens 107-111 11207812-6 2001 In addition, the dopamine D(2) receptor agonist reduced both basal and forskolin-stimulated activity of TH, measured as 3,4-dihydroxyphenylalanine (DOPA) accumulation. Colforsin 71-80 tyrosine hydroxylase Rattus norvegicus 104-106 11168840-7 2001 Furthermore, basal and forskolin-stimulated conditioned medium from hamster pars tuberalis increased prolactin mRNA expression in primary cultures of pars distalis cells. Colforsin 23-32 prolactin Mesocricetus auratus 101-110 11174853-7 2001 Reporter gene expression under the control of proximal POMC promoter elements was stimulated by addition of forskolin to the culture medium or by transfection with expression constructs for human Nak1, the human homologue of Nur77. Colforsin 108-117 proopiomelanocortin Homo sapiens 55-59 11160626-5 2001 JTE-907 showed concentration-dependent increase of forskolin-stimulated cAMP production in CHO cells expressing human and mouse CB2 in vitro, i.e., JTE-907 behaved as an inverse agonist, which is in contrast to Win55212-2 that reduces cAMP as an agonist. Colforsin 51-60 cannabinoid receptor 2 (macrophage) Mus musculus 128-131 11246424-3 2001 The Cytosensor Microphysiometer was used to study forskolin-stimulated extracellular acidification rates in CFTR-expressing and control mouse mammary epithelial (C127) and fibroblast (NIH/3T3) cell lines. Colforsin 50-59 cystic fibrosis transmembrane conductance regulator Mus musculus 108-112 11246424-4 2001 Forskolin, which activates CFTR via raised cAMP, caused decreased extracellular acidification of CFTR-expressing NIH/3T3 and C127 cells by 15-35%. Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 27-31 11246424-4 2001 Forskolin, which activates CFTR via raised cAMP, caused decreased extracellular acidification of CFTR-expressing NIH/3T3 and C127 cells by 15-35%. Colforsin 0-9 cystic fibrosis transmembrane conductance regulator Mus musculus 97-101 11165399-4 2001 PGE2, VIP and forskolin caused increased VEGF expression in a time- and concentration-dependent manner using NSCLC cell line NCI-H157. Colforsin 14-23 vascular endothelial growth factor A Homo sapiens 41-45 11165399-7 2001 Also 1 microM PGE2, 0.1 microM VIP and 50 microM forskolin increased the VEGF mRNA 2.0-, 1.5- and 2.3-fold, respectively, after 4 h. The increase in VEGF mRNA caused by PGE2, VIP and forskolin was inhibited by H-89, a protein kinase A inhibitor. Colforsin 49-58 vascular endothelial growth factor A Homo sapiens 73-77 11565193-3 2001 In this study, we demonstrate that PGE2 enhances the expression of bFGF in normal human fibroblasts, and that calcium ionophore, A23187, and adenylate cyclase activator, forskolin, also enhances the expression bFGF mRNA. Colforsin 170-179 fibroblast growth factor 2 Homo sapiens 210-214 11165399-7 2001 Also 1 microM PGE2, 0.1 microM VIP and 50 microM forskolin increased the VEGF mRNA 2.0-, 1.5- and 2.3-fold, respectively, after 4 h. The increase in VEGF mRNA caused by PGE2, VIP and forskolin was inhibited by H-89, a protein kinase A inhibitor. Colforsin 49-58 vascular endothelial growth factor A Homo sapiens 149-153 11165399-7 2001 Also 1 microM PGE2, 0.1 microM VIP and 50 microM forskolin increased the VEGF mRNA 2.0-, 1.5- and 2.3-fold, respectively, after 4 h. The increase in VEGF mRNA caused by PGE2, VIP and forskolin was inhibited by H-89, a protein kinase A inhibitor. Colforsin 49-58 vasoactive intestinal peptide Homo sapiens 175-178 11165399-7 2001 Also 1 microM PGE2, 0.1 microM VIP and 50 microM forskolin increased the VEGF mRNA 2.0-, 1.5- and 2.3-fold, respectively, after 4 h. The increase in VEGF mRNA caused by PGE2, VIP and forskolin was inhibited by H-89, a protein kinase A inhibitor. Colforsin 183-192 vasoactive intestinal peptide Homo sapiens 31-34 11165399-7 2001 Also 1 microM PGE2, 0.1 microM VIP and 50 microM forskolin increased the VEGF mRNA 2.0-, 1.5- and 2.3-fold, respectively, after 4 h. The increase in VEGF mRNA caused by PGE2, VIP and forskolin was inhibited by H-89, a protein kinase A inhibitor. Colforsin 183-192 vascular endothelial growth factor A Homo sapiens 73-77 11165399-7 2001 Also 1 microM PGE2, 0.1 microM VIP and 50 microM forskolin increased the VEGF mRNA 2.0-, 1.5- and 2.3-fold, respectively, after 4 h. The increase in VEGF mRNA caused by PGE2, VIP and forskolin was inhibited by H-89, a protein kinase A inhibitor. Colforsin 183-192 vascular endothelial growth factor A Homo sapiens 149-153 11589621-3 2001 When compared to the results obtained with normal medium supplemented with regular FBS, the forskolin-stimulated I(SC), presumably mediated by CFTR, obtained in phenol red-free medium was significantly reduced, from 16.95+/-1.53 microA/cm(2)(control) to 9.72+/-0.89 microA/cm(2)(medium without phenol red, P< 0.05). Colforsin 92-101 cystic fibrosis transmembrane conductance regulator Mus musculus 143-147 11169166-8 2001 In rat pituitary cells, contrary to observations in BHK cells, preexposure with both forskolin and db-cAMP desensitised a subsequent growth hormone-releasing hormone stimulation, indicating a heterologous desensitisation. Colforsin 85-94 somatoliberin Mesocricetus auratus 133-165 11162596-5 2001 OPG secretion was decreased by 50% when the human bone marrow stromal cells were treated with 1 microM of prostaglandin E(2), possibly through activation of the protein kinase A-pathway since stimulation of protein kinase A by forskolin also inhibited OPG secretion. Colforsin 227-236 TNF receptor superfamily member 11b Homo sapiens 0-3 11162596-10 2001 Using this ELISA, the amount of OPG secreted from human bone marrow stromal cells was clearly detectable, and the secretion of OPG-protein was potently regulated by prostaglandin E(2), forskolin, phorbol 12,13 di butyrate, IL-1 alpha, TNF-alpha, and dexamethasone. Colforsin 185-194 TNF receptor superfamily member 11b Homo sapiens 32-35 11162596-10 2001 Using this ELISA, the amount of OPG secreted from human bone marrow stromal cells was clearly detectable, and the secretion of OPG-protein was potently regulated by prostaglandin E(2), forskolin, phorbol 12,13 di butyrate, IL-1 alpha, TNF-alpha, and dexamethasone. Colforsin 185-194 TNF receptor superfamily member 11b Homo sapiens 127-130 11022044-6 2001 In this region complex transcriptional regulation occurs, which indicates inhibition of AP-2 CCK promoter complexing by NF-kappa B. Six-point mutations introduced into this sequence prevent AP-2 and NF-kappa B binding to CCK promoter, as well as its transcriptional activation by phorbol ester and forskolin in GH3 cells. Colforsin 298-307 fatty acid binding protein 4 Rattus norvegicus 88-92 11022044-6 2001 In this region complex transcriptional regulation occurs, which indicates inhibition of AP-2 CCK promoter complexing by NF-kappa B. Six-point mutations introduced into this sequence prevent AP-2 and NF-kappa B binding to CCK promoter, as well as its transcriptional activation by phorbol ester and forskolin in GH3 cells. Colforsin 298-307 cholecystokinin Rattus norvegicus 93-96 11022044-6 2001 In this region complex transcriptional regulation occurs, which indicates inhibition of AP-2 CCK promoter complexing by NF-kappa B. Six-point mutations introduced into this sequence prevent AP-2 and NF-kappa B binding to CCK promoter, as well as its transcriptional activation by phorbol ester and forskolin in GH3 cells. Colforsin 298-307 fatty acid binding protein 4 Rattus norvegicus 190-194 11022044-6 2001 In this region complex transcriptional regulation occurs, which indicates inhibition of AP-2 CCK promoter complexing by NF-kappa B. Six-point mutations introduced into this sequence prevent AP-2 and NF-kappa B binding to CCK promoter, as well as its transcriptional activation by phorbol ester and forskolin in GH3 cells. Colforsin 298-307 cholecystokinin Rattus norvegicus 221-224 11211941-7 2001 The production of M-CSF was markedly increased over the basal level after treatment with forskolin (10 microM) for 24 (P < 0.02) and 48 hr (P < 0.01); however, the production of MCP-1 was unchanged. Colforsin 89-98 colony stimulating factor 1 Homo sapiens 18-23 11211941-7 2001 The production of M-CSF was markedly increased over the basal level after treatment with forskolin (10 microM) for 24 (P < 0.02) and 48 hr (P < 0.01); however, the production of MCP-1 was unchanged. Colforsin 89-98 C-C motif chemokine ligand 2 Homo sapiens 184-189 11410709-9 2001 Deletion of either the membrane targeting region of AKAP75 (AKAP45) or PKAII binding domain of AKAP75 (AKAP75DeltaC) abolished the effects of forskolin on ROMK1 channels. Colforsin 142-151 A-kinase anchoring protein 5 Bos taurus 52-58 11410709-9 2001 Deletion of either the membrane targeting region of AKAP75 (AKAP45) or PKAII binding domain of AKAP75 (AKAP75DeltaC) abolished the effects of forskolin on ROMK1 channels. Colforsin 142-151 A-kinase anchoring protein 5 Bos taurus 95-101 11237479-6 2001 The PKA activator, forskolin, induced small increases in bone resorption at lower concentrations (50-500 ng/ml) but a reversal of this effect, and inhibition of resorption induced by other stimuli (PTH, PGE2), at higher concentrations (0.5-5 microg/ml). Colforsin 19-28 parathyroid hormone Mus musculus 198-201 11146049-5 2001 When 2DIV slices were exposed to combined high potassium (K(+), 10 mM) and forskolin (10 microM) stimulation for 3 h, PPT mRNA levels were increased within areas of the brain normally associated with tachykinin production. Colforsin 75-84 tachykinin, precursor 1 Rattus norvegicus 118-121 11762347-6 2001 The activation of these receptors by NPY resulted in a reduction of forskolin-induced cAMP accumulation and an increase of [Ca2+]i. Colforsin 68-77 neuropeptide Y Homo sapiens 37-40 11133671-7 2001 Dexamethasone also decreased StAR protein levels and progesterone production induced by the adenylate cyclase activator forskolin (10(-5) M) or a cAMP analogue 8-Br-cAMP (0.5 mM). Colforsin 120-129 steroidogenic acute regulatory protein Rattus norvegicus 29-33 11410709-9 2001 Deletion of either the membrane targeting region of AKAP75 (AKAP45) or PKAII binding domain of AKAP75 (AKAP75DeltaC) abolished the effects of forskolin on ROMK1 channels. Colforsin 142-151 A-kinase anchoring protein 5 Bos taurus 103-115 11173928-5 2001 This is supported by the ability of the PKA inhibitor Rp-cAMPS to block increases in IGF-I caused by both DPAT and forskolin. Colforsin 115-124 insulin-like growth factor 1 Mus musculus 85-90 11410709-9 2001 Deletion of either the membrane targeting region of AKAP75 (AKAP45) or PKAII binding domain of AKAP75 (AKAP75DeltaC) abolished the effects of forskolin on ROMK1 channels. Colforsin 142-151 potassium inwardly rectifying channel subfamily J member 1 S homeolog Xenopus laevis 155-160 11145564-5 2001 Proglucagon and PC1 messenger RNA transcript levels were both increased after 12 h (but not 24 h) of treatment of GLUTag cells with forskolin/isobutylmethylxanthine (IBMX), by 2.7 +/- 0.3- and 2.4 +/- 0.3-fold, respectively, compared with controls (P < 0.01-0.001). Colforsin 132-141 proprotein convertase subtilisin/kexin type 1 Mus musculus 16-19 11145564-6 2001 Activation of PKA resulted in a 2.1 +/- 0.1-fold increase in PC1 reporter construct expression (P < 0.001) at 12 h, which was dependent on the presence of the CRE, and a 13- to 24-fold increment in PC1 protein levels (P < 0.01) at 12 and 24 h. Similarly, forskolin/IBMX increased secretion of GLP-1, by 1.8 +/- 0.2- and 2.2 +/- 0.6-fold at 12 and 24 h, respectively (P < 0.05-0.01). Colforsin 261-270 proprotein convertase subtilisin/kexin type 1 Mus musculus 61-64 11145564-7 2001 Although the cell content of GLP-1 was diminished after 12 h of treatment (P < 0.001), GLP-1 levels increased back to control values after 24 h of forskolin/IBMX treatment (P < 0.01 vs. 12-h levels). Colforsin 150-159 glucagon Mus musculus 90-95 11149914-5 2001 The effect of beta2-agonists was mimicked by forskolin and 8-bromo-cAMP and potentiated by the cAMP-dependent phosphodiesterase inhibitor rolipram, suggesting that it is cAMP dependent. Colforsin 45-54 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 14-19 11409298-10 2001 Tumour necrosis factor alpha (TNF alpha) stimulated (P < 0.05) VEGF with 10 or 100 ng/ml but not P. TPA (12-0 tetra decaenoyl-phorbol-13-acetate) or Ca2+ ionophore did not show a stimulatory effect in contrast to forskolin which increased P and VEGF secretion dose dependently. Colforsin 216-225 tumor necrosis factor Bos taurus 30-39 11173928-6 2001 Consistent with these results, DPAT and forskolin increased phosphorylation of the cAMP response element binding protein (CREB), which was also blocked by Rp-cAMPS. Colforsin 40-49 cAMP responsive element binding protein 1 Mus musculus 83-120 11173928-6 2001 Consistent with these results, DPAT and forskolin increased phosphorylation of the cAMP response element binding protein (CREB), which was also blocked by Rp-cAMPS. Colforsin 40-49 cAMP responsive element binding protein 1 Mus musculus 122-126 11145992-5 2001 Treatment with forskolin, but not dideoxyforskolin, up-regulates GalR1 transcription, likely through elevation of cAMP levels. Colforsin 15-24 galanin receptor 1 Mus musculus 65-70 11112692-6 2001 When treated with some growth arrest-inducing agents such as sodium nitroprusside, forskolin and butyrolactone I, cells expressing wild-type Akt regained their responsiveness to the effects of NGF on differentiation. Colforsin 83-92 AKT serine/threonine kinase 1 Rattus norvegicus 141-144 11746511-13 2001 The similar biphasic response of OPG to PTH, PTH 1-31, PTHrP 1-34, forskolin, IBMX and dibutyryl cAMP suggests that PTH regulates OPG transcription via activation of the cAMP/PKA signal transduction pathway. Colforsin 67-76 TNF receptor superfamily member 11B Rattus norvegicus 33-36 11123278-8 2001 The cAMP analogue dibutyryl cAMP and the cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine each reversed GD1b-, GT1b-, and GQ1b-induced stimulation of IL-2 and IFN-gamma production and inhibition of IL-4 and IL-5 production at the levels of proteins, transcription, and promoter activities. Colforsin 63-72 interleukin 2 Homo sapiens 165-169 11123278-8 2001 The cAMP analogue dibutyryl cAMP and the cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine each reversed GD1b-, GT1b-, and GQ1b-induced stimulation of IL-2 and IFN-gamma production and inhibition of IL-4 and IL-5 production at the levels of proteins, transcription, and promoter activities. Colforsin 63-72 interferon gamma Homo sapiens 174-183 11123278-8 2001 The cAMP analogue dibutyryl cAMP and the cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine each reversed GD1b-, GT1b-, and GQ1b-induced stimulation of IL-2 and IFN-gamma production and inhibition of IL-4 and IL-5 production at the levels of proteins, transcription, and promoter activities. Colforsin 63-72 interleukin 4 Homo sapiens 213-217 11123278-8 2001 The cAMP analogue dibutyryl cAMP and the cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine each reversed GD1b-, GT1b-, and GQ1b-induced stimulation of IL-2 and IFN-gamma production and inhibition of IL-4 and IL-5 production at the levels of proteins, transcription, and promoter activities. Colforsin 63-72 interleukin 5 Homo sapiens 222-226 11455586-4 2001 Forskolin, a stimulator of cAMP synthesis, was able to increase SAMDC enzyme activity but the response which occurred was dependent upon the cellular phenotype expressed. Colforsin 0-9 S-adenosylmethionine decarboxylase 1 Mus musculus 64-69 11455586-6 2001 Forskolin pre-treatment of C3 cells did result in a marked increase in the half-life of SAMDC mRNA transcripts suggesting a role for post-transcriptional stabilization. Colforsin 0-9 S-adenosylmethionine decarboxylase 1 Mus musculus 88-93 11455586-8 2001 Treatment of malignant C3 cells with both cycloheximide and forskolin together resulted in a further additive elevation in SAMDC message levels. Colforsin 60-69 S-adenosylmethionine decarboxylase 1 Mus musculus 123-128 11964068-9 2001 Here, we demonstrate that KRP is a major phosphoprotein in smooth muscle, and use a comparative approach to investigate how its phosphorylation correlates with sustained contraction and forskolin-induced relaxation. Colforsin 186-195 myosin light chain kinase Homo sapiens 26-29 11145992-6 2001 The region between - 1050 and - 700 base pairs upstream of exon one is necessary both for basal activity of the GalR1 promoter and for forskolin-mediated increases in transcription. Colforsin 135-144 galanin receptor 1 Mus musculus 112-117 11018034-6 2000 This conclusion was further supported by the ability of forskolin (10 microm), an adenylyl cyclase activator, to elevate p38 MAPK activity in a PKI-sensitive manner. Colforsin 56-65 mitogen-activated protein kinase 14 Mus musculus 121-124 12094624-8 2001 Forskolin significantly increased intracellular cAMP level and inhibited cytochrome P-450 2B1 expression in the presence of phenobarbital. Colforsin 0-9 cytochrome P450 2B1 Rattus norvegicus 73-93 11006268-8 2000 TSH and forskolin stimulated the activity of the alpha-isoform of p38-MAPK assayed by phosphorylation of the transcription factor ATF2. Colforsin 8-17 mitogen activated protein kinase 14 Rattus norvegicus 66-69 11006268-8 2000 TSH and forskolin stimulated the activity of the alpha-isoform of p38-MAPK assayed by phosphorylation of the transcription factor ATF2. Colforsin 8-17 activating transcription factor 2 Rattus norvegicus 130-134 11006268-11 2000 The protein kinase A inhibitor H89 inhibited the stimulation of phosphorylation of p38-MAPKs by forskolin, whereas inhibitors of protein kinase C, p70(S6k), and phosphatidylinositol 3-kinase were ineffective. Colforsin 96-105 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 4-20 11174002-8 2001 Forskolin also inhibited the production of MMP-9. Colforsin 0-9 matrix metallopeptidase 9 Homo sapiens 43-48 11145742-8 2001 Functional analysis of SF-1 and NF1 sites in the -121/+41 promoter showed that mutation of one of them decreases both constitutive and forskolin-stimulated promoter activity without affecting the fold induction (forskolin stimulated/basal). Colforsin 135-144 splicing factor 1 Mus musculus 23-27 11145742-8 2001 Functional analysis of SF-1 and NF1 sites in the -121/+41 promoter showed that mutation of one of them decreases both constitutive and forskolin-stimulated promoter activity without affecting the fold induction (forskolin stimulated/basal). Colforsin 135-144 neurofibromin 1 Mus musculus 32-35 11006268-11 2000 The protein kinase A inhibitor H89 inhibited the stimulation of phosphorylation of p38-MAPKs by forskolin, whereas inhibitors of protein kinase C, p70(S6k), and phosphatidylinositol 3-kinase were ineffective. Colforsin 96-105 mitogen activated protein kinase 14 Rattus norvegicus 83-86 11134654-5 2000 Almotriptan inhibited forskolin-stimulated cyclic AMP accumulation in HeLa cells transfected with 5-HT(1B) or 5-HT(1D) human receptors. Colforsin 22-31 5-hydroxytryptamine receptor 1D Homo sapiens 110-117 11006268-12 2000 Expression of the dominant negative form of Rac1, but not that of Ras, blocked forskolin-induced p38-MAPK activation. Colforsin 79-88 Rac family small GTPase 1 Rattus norvegicus 44-48 11006268-12 2000 Expression of the dominant negative form of Rac1, but not that of Ras, blocked forskolin-induced p38-MAPK activation. Colforsin 79-88 mitogen activated protein kinase 14 Rattus norvegicus 97-100 11006268-13 2000 Diphenylene iodonium, a potent inhibitor of NADPH oxidase(s), and ascorbic acid, an effective free radical scavenger, suppressed TSH- or forskolin-stimulated p38-MAPK phosphorylation, indicating that the generation of reactive oxygen species plays a key role in signaling from cAMP to p38-MAPKs. Colforsin 137-146 mitogen activated protein kinase 14 Rattus norvegicus 158-161 11006268-13 2000 Diphenylene iodonium, a potent inhibitor of NADPH oxidase(s), and ascorbic acid, an effective free radical scavenger, suppressed TSH- or forskolin-stimulated p38-MAPK phosphorylation, indicating that the generation of reactive oxygen species plays a key role in signaling from cAMP to p38-MAPKs. Colforsin 137-146 mitogen activated protein kinase 14 Rattus norvegicus 285-294 11118322-8 2000 Although VPATPD and HSD11B2 are both expressed in kidney and placenta, they are regulated differently; forskolin upregulates HSD11B2 but not VPATPD in human choriocarcinoma JEG3 cells. Colforsin 103-112 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 125-132 11118334-3 2000 HH4R-expressing cells responded to histamine, inhibiting forskolin-induced cAMP accumulation. Colforsin 57-66 histamine receptor H4 Homo sapiens 0-4 11118334-5 2000 RAMHA, NAMHA, and imetit inhibited forskolin-induced cAMP accumulation in HH4R-expressing cells. Colforsin 35-44 histamine receptor H4 Homo sapiens 74-78 11162896-3 2000 Cells were also treated with different concentration of TGFbeta1 in the presence of forskolin, combined steroid production was measured at the end of 48 h and after 3 h incubation with 22R-hydroxycholesterol. Colforsin 84-93 transforming growth factor beta 1 Homo sapiens 56-64 11113530-0 2000 The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes. Colforsin 90-99 proenkephalin Rattus norvegicus 49-62 11102578-7 2000 Forskolin (100 microM) attenuated the effect of bFGF on neuronal survival and neurite branch formation, indicating that cyclic AMP plays negative regulatory roles in these actions of bFGF. Colforsin 0-9 fibroblast growth factor 2 Rattus norvegicus 48-52 11102578-7 2000 Forskolin (100 microM) attenuated the effect of bFGF on neuronal survival and neurite branch formation, indicating that cyclic AMP plays negative regulatory roles in these actions of bFGF. Colforsin 0-9 fibroblast growth factor 2 Rattus norvegicus 183-187 11134654-5 2000 Almotriptan inhibited forskolin-stimulated cyclic AMP accumulation in HeLa cells transfected with 5-HT(1B) or 5-HT(1D) human receptors. Colforsin 22-31 5-hydroxytryptamine receptor 1B Homo sapiens 98-105 11112429-3 2000 In these cultures, S1P inhibited forskolin-driven rises in cAMP and this response was eliminated by pretreatment of the cultures with pertussis toxin. Colforsin 33-42 membrane-bound transcription factor peptidase, site 1 Danio rerio 19-22 11113530-7 2000 Dexamethasone (DEX; 1 microM) further enhanced FSK- or PMA-induced proENK mRNA expression, which was not correlated with the activation of AP-1 expression and CREB phosphorylation, suggesting that synergistic interaction of glucocorticoid with PKA or PKC pathway for the regulation of proENK mRNA expression appears to be mediated by other pathways rather than CREB and AP-1 families. Colforsin 47-50 proenkephalin Rattus norvegicus 67-73 11113530-1 2000 In rat astrocytes, forskolin (FSK; 5 microM) and phorbol-12-myristic-13-acetate (PMA; 2.5 microM) increase the proenkephalin (proENK) mRNA level via different pathways. Colforsin 19-28 proenkephalin Rattus norvegicus 111-124 11113530-7 2000 Dexamethasone (DEX; 1 microM) further enhanced FSK- or PMA-induced proENK mRNA expression, which was not correlated with the activation of AP-1 expression and CREB phosphorylation, suggesting that synergistic interaction of glucocorticoid with PKA or PKC pathway for the regulation of proENK mRNA expression appears to be mediated by other pathways rather than CREB and AP-1 families. Colforsin 47-50 proenkephalin Rattus norvegicus 285-291 11113530-1 2000 In rat astrocytes, forskolin (FSK; 5 microM) and phorbol-12-myristic-13-acetate (PMA; 2.5 microM) increase the proenkephalin (proENK) mRNA level via different pathways. Colforsin 19-28 proenkephalin Rattus norvegicus 126-132 11113530-7 2000 Dexamethasone (DEX; 1 microM) further enhanced FSK- or PMA-induced proENK mRNA expression, which was not correlated with the activation of AP-1 expression and CREB phosphorylation, suggesting that synergistic interaction of glucocorticoid with PKA or PKC pathway for the regulation of proENK mRNA expression appears to be mediated by other pathways rather than CREB and AP-1 families. Colforsin 47-50 cAMP responsive element binding protein 1 Rattus norvegicus 361-365 11113544-3 2000 D2 dopamine receptor expression was confirmed by quinpirole inhibition of forskolin-stimulated cAMP formation. Colforsin 74-83 dopamine receptor D2 Homo sapiens 0-20 11134581-12 2000 Forskolin selectively induces IRBP gene expression in the laminin-treated cells through a cAMP-mediated pathway without de novo protein synthesis. Colforsin 0-9 retinol binding protein 3 Homo sapiens 30-34 11113530-1 2000 In rat astrocytes, forskolin (FSK; 5 microM) and phorbol-12-myristic-13-acetate (PMA; 2.5 microM) increase the proenkephalin (proENK) mRNA level via different pathways. Colforsin 30-33 proenkephalin Rattus norvegicus 111-124 11113530-1 2000 In rat astrocytes, forskolin (FSK; 5 microM) and phorbol-12-myristic-13-acetate (PMA; 2.5 microM) increase the proenkephalin (proENK) mRNA level via different pathways. Colforsin 30-33 proenkephalin Rattus norvegicus 126-132 11113530-2 2000 FSK-induced proENK mRNA expression is independent of protein de novo synthesis, and well correlated with CREB phosphorylation. Colforsin 0-3 proenkephalin Rattus norvegicus 12-18 11113530-2 2000 FSK-induced proENK mRNA expression is independent of protein de novo synthesis, and well correlated with CREB phosphorylation. Colforsin 0-3 cAMP responsive element binding protein 1 Rattus norvegicus 105-109 11113530-6 2000 The combined treatment with FSK and PMA additively increased the proENK mRNA level, which was correlated with AP-1 or ENKCRE-2 DNA binding activity, and CREB phosphorylation. Colforsin 28-31 proenkephalin Rattus norvegicus 65-71 11113530-6 2000 The combined treatment with FSK and PMA additively increased the proENK mRNA level, which was correlated with AP-1 or ENKCRE-2 DNA binding activity, and CREB phosphorylation. Colforsin 28-31 cAMP responsive element binding protein 1 Rattus norvegicus 153-157 11087235-4 2000 Pretreatment of aortic rings from 6-wk-old or 6-mo-old male Fischer 344 rats with ANG II significantly enhanced vasorelaxation induced by isoproterenol (Iso), a beta-AR agonist, and forskolin, a direct activator of adenylyl cyclase, but not dibutyryl-cAMP or isobutylmethylxanthine. Colforsin 182-191 angiotensinogen Rattus norvegicus 82-88 11095748-3 2000 Compound sst(3)-ODN-8 potently reverses the somatostatin-28-induced inhibition of forskolin-stimulated cAMP production (pK(B) = 9.07) and reverses the somatostatin-28-induced stimulation of phospholipase C activity (pK(i) = 9.22) in sst(3)-transfected CCL39 cells. Colforsin 82-91 somatostatin Homo sapiens 44-59 11116053-4 2000 Treatment of VSMC with agents that increase intracellular cAMP (eg, forskolin, dibutyryl [db]-cAMP) resulted in a time- and concentration-dependent increase in sPLA(2) gene expression. Colforsin 68-77 phospholipase A2 group IIA Rattus norvegicus 160-167 11112151-6 2000 PGE(2) increased adenylate cyclase activity in a concentration dependent manner, and forskolin, a direct activator of adenylate cyclase, caused a marked increase in IL-1 beta-dependent COX-2, suggesting the existence of a causal relationship between the two events. Colforsin 85-94 interleukin 1 beta Homo sapiens 165-174 11112151-6 2000 PGE(2) increased adenylate cyclase activity in a concentration dependent manner, and forskolin, a direct activator of adenylate cyclase, caused a marked increase in IL-1 beta-dependent COX-2, suggesting the existence of a causal relationship between the two events. Colforsin 85-94 mitochondrially encoded cytochrome c oxidase II Homo sapiens 185-190 11104733-4 2000 Pretreatment of HASM with prostaglandin (PG) E(2), forskolin, or dibutyryl cAMP inhibited TNF-alpha-induced RANTES secretion but increased TNF-alpha-induced IL-6 secretion. Colforsin 51-60 tumor necrosis factor Homo sapiens 90-99 11104733-4 2000 Pretreatment of HASM with prostaglandin (PG) E(2), forskolin, or dibutyryl cAMP inhibited TNF-alpha-induced RANTES secretion but increased TNF-alpha-induced IL-6 secretion. Colforsin 51-60 C-C motif chemokine ligand 5 Homo sapiens 108-114 11104733-4 2000 Pretreatment of HASM with prostaglandin (PG) E(2), forskolin, or dibutyryl cAMP inhibited TNF-alpha-induced RANTES secretion but increased TNF-alpha-induced IL-6 secretion. Colforsin 51-60 tumor necrosis factor Homo sapiens 139-148 11104733-5 2000 Moreover, stimulation with PGE(2), forskolin, or dibutyryl cAMP alone increased basal IL-6 secretion in a concentration-dependent manner. Colforsin 35-44 interleukin 6 Homo sapiens 86-90 11104733-6 2000 SB 207499, a specific phosphodiesterase type 4 inhibitor, augmented the inhibitory effects of PGE(2) and forskolin on TNF-alpha-induced RANTES. Colforsin 105-114 tumor necrosis factor Homo sapiens 118-127 11104733-6 2000 SB 207499, a specific phosphodiesterase type 4 inhibitor, augmented the inhibitory effects of PGE(2) and forskolin on TNF-alpha-induced RANTES. Colforsin 105-114 C-C motif chemokine ligand 5 Homo sapiens 136-142 11116053-7 2000 Incubation of VSMC with H89, a specific protein kinase inhibitor, also blocked the binding of nuclear C/EBP to the C/EBP site of the rat promoter induced by db-cAMP and forskolin. Colforsin 169-178 CCAAT/enhancer binding protein gamma Rattus norvegicus 102-107 11116053-7 2000 Incubation of VSMC with H89, a specific protein kinase inhibitor, also blocked the binding of nuclear C/EBP to the C/EBP site of the rat promoter induced by db-cAMP and forskolin. Colforsin 169-178 CCAAT/enhancer binding protein gamma Rattus norvegicus 115-120 11108265-8 2000 Treatment of UMR 106 osteosarcoma cells with PTH, PGE2, forskolin, or (Bu)2cAMP increased ADAMTS-1 expression 7-, 4-, 5-, and 5-fold, respectively. Colforsin 56-65 ADAM metallopeptidase with thrombospondin type 1 motif, 1 Rattus norvegicus 90-98 11122302-8 2000 This regulation is mediated by cAMP as forskolin and 8-Bromo-cAMP also increased Tie-2 expression. Colforsin 39-48 TEK receptor tyrosine kinase Rattus norvegicus 81-86 11108286-13 2000 Forskolin enhanced RANKL mRNA expression but suppressed OPG mRNA expression in primary osteoblasts. Colforsin 0-9 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 19-24 11090432-6 2000 An inhibitor of protein kinase A, Rp-cAMPS, caused a 50% inhibition of Sertoli cell testin expression at 10 microM within 24 h. A biphasic response was noted in testin expression when forskolin was included in the Sertoli cell culture, and high concentrations of cAMP analogues (1 mM) rapidly reduced testin expression. Colforsin 184-193 testin gene Rattus norvegicus 161-167 11090432-6 2000 An inhibitor of protein kinase A, Rp-cAMPS, caused a 50% inhibition of Sertoli cell testin expression at 10 microM within 24 h. A biphasic response was noted in testin expression when forskolin was included in the Sertoli cell culture, and high concentrations of cAMP analogues (1 mM) rapidly reduced testin expression. Colforsin 184-193 testin gene Rattus norvegicus 161-167 11108271-12 2000 It contains several conserved AP-2 and Sp1 consensus binding sequences that may be important for the effects of IGF-I and forskolin on IGFBP-3 promoter activity. Colforsin 122-131 insulin like growth factor binding protein 3 Bos taurus 135-142 11108286-13 2000 Forskolin enhanced RANKL mRNA expression but suppressed OPG mRNA expression in primary osteoblasts. Colforsin 0-9 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 56-59 11108271-2 2000 The synthesis of IGFBP-3 is stimulated by both IGF-I and agents that increase intracellular cAMP (e.g. forskolin) in the bovine MEC line MAC-T. Colforsin 103-112 insulin like growth factor binding protein 3 Bos taurus 17-24 11108271-5 2000 The half-life of IGFBP-3 messenger RNA in untreated MAC-T cells was determined to be 11 h. Exposure to IGF-I or forskolin increased the half-life to 27 and 101 h, respectively. Colforsin 112-121 insulin like growth factor binding protein 3 Bos taurus 17-24 11108271-6 2000 Nuclear run-on assays indicated that IGFBP-3 transcription rates were increased 3.5 +/- 0.83-fold (n = 4) in cells treated with a combination of IGF-I and forskolin. Colforsin 155-164 insulin like growth factor binding protein 3 Bos taurus 37-44 11108271-8 2000 Transient transfection assays indicated that both IGF-I and forskolin alone produced small, but significant, increases in IGFBP-3 promoter activity of 1.57 +/- 0.12 and 1.59 +/- 0.08-fold (P < 0.01), respectively (mean +/- SE; n = 7). Colforsin 60-69 insulin like growth factor binding protein 3 Bos taurus 122-129 11108271-9 2000 However, the combination of IGF-I and forskolin increased IGFBP-3 promoter activity 2.25 +/- 0.14-fold above control values (P < 0.01), suggesting that these factors activate discrete signaling pathways that act in concert to stimulate IGFBP-3 gene transcription. Colforsin 38-47 insulin like growth factor binding protein 3 Bos taurus 58-65 11108271-9 2000 However, the combination of IGF-I and forskolin increased IGFBP-3 promoter activity 2.25 +/- 0.14-fold above control values (P < 0.01), suggesting that these factors activate discrete signaling pathways that act in concert to stimulate IGFBP-3 gene transcription. Colforsin 38-47 insulin like growth factor binding protein 3 Bos taurus 239-246 11093795-11 2000 Finally, isoproterenol and forskolin activated ERK, an effect that was blunted by propranolol. Colforsin 27-36 Eph receptor B1 Rattus norvegicus 47-50 11086074-4 2000 Treatments that inhibit macrophage proliferation by blocking the cell cycle at the G(1) phase, such as adenosine, forskolin, or LPS, blocked the IFN-gamma induction of IA. Colforsin 114-123 interferon gamma Homo sapiens 145-154 11216650-4 2000 This stimulatory effect of IL-6 became apparent at intervals as short as 4 h and continued through 24 h. IL-6 also potentiated the cortisol release stimulated by the adenylyl cyclase activator forskolin. Colforsin 193-202 interleukin 6 Bos taurus 27-31 11216650-4 2000 This stimulatory effect of IL-6 became apparent at intervals as short as 4 h and continued through 24 h. IL-6 also potentiated the cortisol release stimulated by the adenylyl cyclase activator forskolin. Colforsin 193-202 interleukin 6 Bos taurus 105-109 11216650-6 2000 The inhibitory effects of TNF-alpha on cortisol release were significant at time intervals as short as 4 h and continued through 24 h. TNF-alpha inhibited forskolin-stimulated cortisol release. Colforsin 155-164 tumor necrosis factor Bos taurus 26-35 11216650-6 2000 The inhibitory effects of TNF-alpha on cortisol release were significant at time intervals as short as 4 h and continued through 24 h. TNF-alpha inhibited forskolin-stimulated cortisol release. Colforsin 155-164 tumor necrosis factor Bos taurus 135-144 11056011-5 2000 Secretion of mucin was detected 15 min following exposure to forskolin, and continued to increase for a further 15 min before reaching a plateau. Colforsin 61-70 LOC100508689 Homo sapiens 13-18 11093787-7 2000 Dibutyryl-cyclic AMP and forskolin mimic the synergistic effect of isoproterenol on IL-1beta-induced NO production; H-89, a cyclic AMP-dependent protein kinase (PKA) inhibitor, antagonizes the enhancing effect of isoproterenol. Colforsin 25-34 interleukin 1 beta Rattus norvegicus 84-92 11080516-4 2000 Activation of cAMP-dependent protein kinase by forskolin and 8-bromo-cAMP increased the level of phosphorylated inhibitor-1. Colforsin 47-56 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 112-123 10938284-7 2000 In the human neuroblastoma cell line SK-N-SH, SYT IV is an immediate-early gene inducible by elevated intracellular calcium and by forskolin, an activator of adenylyl cyclase. Colforsin 131-140 synaptotagmin 4 Homo sapiens 46-52 11082292-6 2000 Furthermore, we also observed that DMSO and forskolin, two agents that inhibit the proliferation of 7TD1 cells, inhibit in parallel cyclin D2 and JNK1. Colforsin 44-53 cyclin D2 Mus musculus 132-141 11082292-6 2000 Furthermore, we also observed that DMSO and forskolin, two agents that inhibit the proliferation of 7TD1 cells, inhibit in parallel cyclin D2 and JNK1. Colforsin 44-53 mitogen-activated protein kinase 8 Mus musculus 146-150 11082292-7 2000 Altogether our results suggest that (i) JNK1 participates in the signaling pathway which controls the expression of cyclin D2 and (ii) that the inhibition of JNK1 by DMSO and forskolin could explain, at least in part, the antiproliferative action of these drugs in 7TD1 cells. Colforsin 175-184 mitogen-activated protein kinase 8 Mus musculus 40-44 11082292-7 2000 Altogether our results suggest that (i) JNK1 participates in the signaling pathway which controls the expression of cyclin D2 and (ii) that the inhibition of JNK1 by DMSO and forskolin could explain, at least in part, the antiproliferative action of these drugs in 7TD1 cells. Colforsin 175-184 cyclin D2 Mus musculus 116-125 11082292-7 2000 Altogether our results suggest that (i) JNK1 participates in the signaling pathway which controls the expression of cyclin D2 and (ii) that the inhibition of JNK1 by DMSO and forskolin could explain, at least in part, the antiproliferative action of these drugs in 7TD1 cells. Colforsin 175-184 mitogen-activated protein kinase 8 Mus musculus 158-162 11138844-4 2000 After TGF-beta1 treatment, the basal, procaterol- and forskolin-stimulated cAMP accumulations were also decreased. Colforsin 54-63 transforming growth factor beta 1 Homo sapiens 6-15 11154118-9 2000 Resting platelets treated with PGI2 and forskolin bound to immobilised recombinant amphoterin independently of divalent cations. Colforsin 40-49 high mobility group box 1 Homo sapiens 83-93 10969067-7 2000 In both rat PC12 and mouse AtT-20 cells, EP24.15 was serine-phosphorylated, and EP24.15 phosphate incorporation was enhanced by forskolin treatment, and attenuated by H89, consistent with PKA-mediated phosphorylation. Colforsin 128-137 thimet oligopeptidase 1 Rattus norvegicus 80-87 11087670-0 2000 Characterization of the adrenoleukodystrophy-related (ALDR, ABCD2) gene promoter: inductibility by retinoic acid and forskolin. Colforsin 117-126 ATP binding cassette subfamily D member 2 Homo sapiens 54-58 11084285-4 2000 Release of IL-8 was down-regulated by transforming growth factor beta2 (TGF-beta2), by the protein tyrosine-kinase inhibitor genistein, and via rises in intracellular cyclic AMP, generated by prostaglandin E(2), rolipram, pentoxifylline, forskolin, or dibutyryl-cyclic AMP. Colforsin 238-247 C-X-C motif chemokine ligand 8 Homo sapiens 11-15 11087670-0 2000 Characterization of the adrenoleukodystrophy-related (ALDR, ABCD2) gene promoter: inductibility by retinoic acid and forskolin. Colforsin 117-126 ATP binding cassette subfamily D member 2 Homo sapiens 60-65 11068015-4 2000 Pretreatment of cells with forskolin, that activates protein kinase-A by direct activation of adenylate cyclase, also caused adrenomedullin receptor desensitization. Colforsin 27-36 adrenomedullin Rattus norvegicus 125-139 11103806-7 2000 Furthermore, inhibition of JNK1 by treatment of the cells with forskolin or by pretreatment with an antisense oligonucleotide directed against JNK1 mRNA resulted in a decrease in F-ara-A-induced apoptosis. Colforsin 63-72 mitogen-activated protein kinase 8 Homo sapiens 27-31 11078876-2 2000 Forskolin was as potent as serum in stimulating MKP-1 gene expression, whereas dibutyryl-cAMP and neuropeptide PACAP were less effective. Colforsin 0-9 dual specificity phosphatase 1 Rattus norvegicus 48-53 11196473-6 2000 Both hCYP11B2 and hCYP11B1 driven reporter constructs responded in a similar manner to treatment with angiotensin II, potassium, dbcAMP, or forskolin. Colforsin 140-149 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 5-13 11196411-7 2000 Under the same conditions, ACTH or forskolin substantially stimulated CYP 17 mRNA accumulation. Colforsin 35-44 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 70-76 11196415-2 2000 We observed that StAR mRNA levels rapidly increased in response to forskolin, starting after 2 h of treatment and reaching a maximum by 12 h. Deletion analysis of the human StAR promoter demonstrated that the first 150 bp upstream of the transcription start were sufficient for both basal and cAMP-induced expression of a reporter gene. Colforsin 67-76 steroidogenic acute regulatory protein Homo sapiens 17-21 11196415-2 2000 We observed that StAR mRNA levels rapidly increased in response to forskolin, starting after 2 h of treatment and reaching a maximum by 12 h. Deletion analysis of the human StAR promoter demonstrated that the first 150 bp upstream of the transcription start were sufficient for both basal and cAMP-induced expression of a reporter gene. Colforsin 67-76 steroidogenic acute regulatory protein Homo sapiens 173-177 11052995-7 2000 PYY secretion stimulated by phorbol 12-myristate 13-acetate and by forskolin was also more potently suppressed by S-28 and the octapeptide SSTR-5 analogs. Colforsin 67-76 peptide YY Rattus norvegicus 0-3 11196481-3 2000 It reached the maximum within a few hours and returned to the base after 8 h. In contrast, the levels of mRNAs for CYP11A and StAR protein reached the maxima after 8 h. The SIK"s mRNA induction failed to occur in ACTH-, forskolin- or 8-Br-cAMP-treated Kin-7 cells, a mutant cell line of Y-1 with defective cAMP-dependent protein kinase A (PKA). Colforsin 220-229 cytochrome P450, family 11, subfamily a, polypeptide 1 Mus musculus 115-121 11196481-3 2000 It reached the maximum within a few hours and returned to the base after 8 h. In contrast, the levels of mRNAs for CYP11A and StAR protein reached the maxima after 8 h. The SIK"s mRNA induction failed to occur in ACTH-, forskolin- or 8-Br-cAMP-treated Kin-7 cells, a mutant cell line of Y-1 with defective cAMP-dependent protein kinase A (PKA). Colforsin 220-229 salt inducible kinase 1 Mus musculus 173-176 11196473-6 2000 Both hCYP11B2 and hCYP11B1 driven reporter constructs responded in a similar manner to treatment with angiotensin II, potassium, dbcAMP, or forskolin. Colforsin 140-149 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 18-26 10922374-10 2000 In contrast H89, an inhibitor of both PKA and cGK, clearly inhibited 8-pCPT-cGMP and forskolin-stimulated VASP phosphorylation in the two cell types. Colforsin 85-94 protein kinase cGMP-dependent 1 Homo sapiens 46-49 11196481-9 2000 The nuclear/cytosol re-distribution of GFP-SIK was also observed in forskolin- or 8-Br-cAMP-treated Y-1 cells, but not in Kin-7 cells. Colforsin 68-77 salt inducible kinase 1 Mus musculus 43-46 11246817-6 2000 Moreover, addition of cAMP-elevating agents such as dibutyryl-cAMP, forskolin and the phosphodiesterase inhibitors isobutyl-methylxanthine and milrinone resulted in a reduction of PAI-1 of varying degrees. Colforsin 68-77 serpin family E member 1 Homo sapiens 180-185 11246822-10 2000 Neither noradrenaline nor the beta3-adrenoceptor agonist, BRL 37 344, altered metallothionein release but forskolin and bromo-cAMP were stimulatory, markedly increasing both metallothionein-1 level and metallothionein secretion. Colforsin 106-115 metallothionein 1 Rattus norvegicus 174-191 11029487-0 2000 Forskolin increases the expression of the pancreatic tumor antigen, Nd2, and uptake of Nd2 antibody. Colforsin 0-9 mitochondrially encoded NADH dehydrogenase 2 Homo sapiens 68-71 11029487-0 2000 Forskolin increases the expression of the pancreatic tumor antigen, Nd2, and uptake of Nd2 antibody. Colforsin 0-9 mitochondrially encoded NADH dehydrogenase 2 Homo sapiens 87-90 11029487-3 2000 In the present study we show that the uptake of radiolabeled Nd2 antibody by SW1990 pancreatic carcinoma cells was increased by the adenyl cyclase activator, forskolin. Colforsin 158-167 mitochondrially encoded NADH dehydrogenase 2 Homo sapiens 61-64 11029487-4 2000 Dibutyryl cyclic AMP and forskolin were both effective in increasing the level of Nd2 antigen in SW1990 cells. Colforsin 25-34 mitochondrially encoded NADH dehydrogenase 2 Homo sapiens 82-85 11029487-6 2000 Forskolin increased Nd2/MUC1 antigen in both a membrane fraction and a high buoyant density mucin-like fraction. Colforsin 0-9 mitochondrially encoded NADH dehydrogenase 2 Homo sapiens 20-23 11029487-6 2000 Forskolin increased Nd2/MUC1 antigen in both a membrane fraction and a high buoyant density mucin-like fraction. Colforsin 0-9 mucin 1, cell surface associated Homo sapiens 24-28 11029487-6 2000 Forskolin increased Nd2/MUC1 antigen in both a membrane fraction and a high buoyant density mucin-like fraction. Colforsin 0-9 LOC100508689 Homo sapiens 92-97 10934195-7 2000 Forskolin and phorbol myristate acetate acted synergistically to enhance transcription of an AP1(-73COL)-luciferase construct. Colforsin 0-9 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 93-96 11095474-6 2000 Signaling experiments revealed that M&B28767, an EP3 agonist, not only inhibited forskolin-induced cAMP concentrations, but also activated mitogen-activated protein kinase in Chinese hamster ovary cells stably expressing EP3-V and EP3-VI. Colforsin 85-94 prostaglandin E receptor 3 Homo sapiens 53-56 11095474-6 2000 Signaling experiments revealed that M&B28767, an EP3 agonist, not only inhibited forskolin-induced cAMP concentrations, but also activated mitogen-activated protein kinase in Chinese hamster ovary cells stably expressing EP3-V and EP3-VI. Colforsin 85-94 prostaglandin E receptor 3 Homo sapiens 225-228 11095474-6 2000 Signaling experiments revealed that M&B28767, an EP3 agonist, not only inhibited forskolin-induced cAMP concentrations, but also activated mitogen-activated protein kinase in Chinese hamster ovary cells stably expressing EP3-V and EP3-VI. Colforsin 85-94 prostaglandin E receptor 3 Homo sapiens 235-241 11067991-11 2000 We found that forskolin/IBMX-induced synaptic facilitation was deficient in area CA1 of DBA/2J and CBA/J slices, but not in BL/6J and 129/SvEms/J slices. Colforsin 14-23 carbonic anhydrase 1 Mus musculus 81-84 11040036-6 2000 Furthermore, stimulation of adenylate cyclase with forskolin, or loading of HMC-1 with the cell-permeable cAMP analog 8-Br-cAMP, activated Cdc42. Colforsin 51-60 cell division cycle 42 Homo sapiens 139-144 11101146-6 2000 Temporal profiles of increases in c-fos mRNA by R(+)-SKF-38393 (50 microM) and forskolin (50 microM) were similar to that of dopamine. Colforsin 79-88 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 34-39 11101146-9 2000 However, when cells were treated with dopamine, an increase in the expression of c-Fos immunoreactivity was observed after treatment for 2 h. The treatment of hippocampal neurons with R(+)-SKF38393 (50 microM) or forskolin (50 microM) also induced a significant increase in c-Fos expression. Colforsin 213-222 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 81-86 10944524-5 2000 Moreover, agents that activate intracellular PKA, such as forskolin, dibutyryl cAMP or alpha(5)beta(1) antagonists, suppress endothelial cell migration on vitronectin in vitro or angiogenesis in vivo. Colforsin 58-67 vitronectin Homo sapiens 155-166 10922374-10 2000 In contrast H89, an inhibitor of both PKA and cGK, clearly inhibited 8-pCPT-cGMP and forskolin-stimulated VASP phosphorylation in the two cell types. Colforsin 85-94 vasodilator stimulated phosphoprotein Homo sapiens 106-110 11027674-9 2000 Results show that ZK98299 inhibited the stimulatory effect of hCG (or forskolin) on PAC(1) mRNA expression, at the level of all known splice variants of PAC(1) mRNA in granulosa cells. Colforsin 70-79 ADCYAP receptor type I Homo sapiens 84-90 11064152-11 2000 StAR expression was elevated by 8.3-, 2.5- and 4.7-fold upon stimulation with forskolin, isoproterenol and adrenalin, respectively. Colforsin 78-87 steroidogenic acute regulatory protein Homo sapiens 0-4 11005757-5 2000 Ion-replacement studies demonstrated that the forskolin response in the NKCC1 -/- jejuna was HCO(3)(-) dependent, whereas in the normal jejuna it was independent of the HCO(3)(-) concentration in the buffer. Colforsin 46-55 solute carrier family 12, member 2 Mus musculus 72-77 11005757-6 2000 NKCC1 -/- ceca exhibited a forskolin response that did not differ significantly from that of normal ceca, but unlike that of normal ceca, was bumetanide insensitive. Colforsin 27-36 solute carrier family 12, member 2 Mus musculus 0-5 10993847-5 2000 In immortalized theca cells, GDF-9 attenuated the forskolin-stimulated progesterone accumulation. Colforsin 50-59 growth differentiation factor 9 Rattus norvegicus 29-34 11089918-8 2000 Dibutyryl cAMP (cAMP agonist) and forskolin (cAMP-increasing agent) augmented the VD3-dependent induction of CD157 and CD11b expression while PGE1 (cAMP-decreasing agent) inhibited it, suggesting the involvement of a cAMP-dependent mechanism in VD3-induced CD157 upregulation. Colforsin 34-43 bone marrow stromal cell antigen 1 Homo sapiens 109-114 11015292-2 2000 In whole oocytes, the CFTR Cl(-) current (I(CFTR)) was activated by superfusion with isobutylmethylxanthine and forskolin. Colforsin 112-121 CF transmembrane conductance regulator Homo sapiens 22-49 11014221-7 2000 The adenylyl cyclase activator forskolin, nerve growth factor, and retinoic acid also activated the chromogranin B gene. Colforsin 31-40 chromogranin B Mus musculus 100-114 11089918-8 2000 Dibutyryl cAMP (cAMP agonist) and forskolin (cAMP-increasing agent) augmented the VD3-dependent induction of CD157 and CD11b expression while PGE1 (cAMP-decreasing agent) inhibited it, suggesting the involvement of a cAMP-dependent mechanism in VD3-induced CD157 upregulation. Colforsin 34-43 integrin subunit alpha M Homo sapiens 119-124 11089918-8 2000 Dibutyryl cAMP (cAMP agonist) and forskolin (cAMP-increasing agent) augmented the VD3-dependent induction of CD157 and CD11b expression while PGE1 (cAMP-decreasing agent) inhibited it, suggesting the involvement of a cAMP-dependent mechanism in VD3-induced CD157 upregulation. Colforsin 34-43 bone marrow stromal cell antigen 1 Homo sapiens 257-262 11057434-5 2000 RESULTS: In the presence of low glucose concentrations (5 mmol/l), insulin enhanced isoproterenol-, forskolin- and cholera toxin-stimulated adenylyl cyclase activities. Colforsin 100-109 insulin Homo sapiens 67-74 11061546-9 2000 The hCG-induced decrease in ERalpha and ERbeta expression was mimicked by 8-bromo-cAMP (1 mmol/L) and forskolin (10 micromol/L) treatment. Colforsin 102-111 estrogen receptor 1 Homo sapiens 28-35 11061546-9 2000 The hCG-induced decrease in ERalpha and ERbeta expression was mimicked by 8-bromo-cAMP (1 mmol/L) and forskolin (10 micromol/L) treatment. Colforsin 102-111 estrogen receptor 2 Homo sapiens 40-46 11061546-15 2000 In agreement with the semiquantitative RT-PCR results, Western blot analysis detected a decrease in ERalpha and ERbeta proteins levels in hGLCs after treatment with hCG (10 IU/mL), GnRH (0.1 micromol/L), 8-bromo-cAMP (1 mmol/L), forskolin (10 micromol/L), or phorbol 12-myristate 13 acetate (10 micromol/L). Colforsin 229-238 estrogen receptor 1 Homo sapiens 100-107 11061546-15 2000 In agreement with the semiquantitative RT-PCR results, Western blot analysis detected a decrease in ERalpha and ERbeta proteins levels in hGLCs after treatment with hCG (10 IU/mL), GnRH (0.1 micromol/L), 8-bromo-cAMP (1 mmol/L), forskolin (10 micromol/L), or phorbol 12-myristate 13 acetate (10 micromol/L). Colforsin 229-238 estrogen receptor 2 Homo sapiens 112-118 11014859-5 2000 The nucleotide [Ca(2+)](i) response could be mimicked by activation of CFTR with forskolin (20 microm) in a temperature-dependent manner. Colforsin 81-90 CF transmembrane conductance regulator Homo sapiens 71-75 11007895-5 2000 Furthermore, addition of BMP2 plus forskolin in decreased oxygen cultures elicited differentiation of thousands of cells expressing tyrosine hydroxylase, dopamine-beta-hydroxylase, and the SA lineage marker SA-1 in nearly all colonies. Colforsin 35-44 dopamine beta-hydroxylase Homo sapiens 154-179 10999939-5 2000 Forskolin and interleukin-1beta are substantially weaker COX-2 mRNA inducers, and CsA does not inhibit their effect. Colforsin 0-9 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 57-62 11154420-7 2000 Dibutyryl cAMP, a cAMP analogue, and forskolin, a direct activator of adenylate cyclase, significantly inhibited TNF alpha-induced ICAM-1 expression in oral gingival epithelial cells. Colforsin 37-46 tumor necrosis factor Homo sapiens 113-122 10999953-3 2000 On the other hand, treatment with forskolin resulted in a large reduction of alpha2C-AR number. Colforsin 34-43 adrenoceptor alpha 2C Homo sapiens 77-87 11154420-7 2000 Dibutyryl cAMP, a cAMP analogue, and forskolin, a direct activator of adenylate cyclase, significantly inhibited TNF alpha-induced ICAM-1 expression in oral gingival epithelial cells. Colforsin 37-46 intercellular adhesion molecule 1 Homo sapiens 131-137 10880520-3 2000 In recombinant Chinese hamster ovary cells expressing the human ORL1 receptor, [Bpa(10),Tyr(14)]noc binds the receptor with high affinity (K(i) approximately 0.7 nm) and is as potent as nociceptin in the inhibition of forskolin-induced cAMP synthesis (EC(50) approximately 0.5 nm). Colforsin 218-227 opioid related nociceptin receptor 1 Homo sapiens 64-68 11006079-3 2000 However, the magnitude of the forskolin-induced Isc, previously demonstrated to be mediated by CFTR, decreased as the amiloride sensitivity of the basal current increased, suggesting a possible inhibitory effect of elevated expression of ENaC on CFTR-mediated Cl(-) secretion. Colforsin 30-39 cystic fibrosis transmembrane conductance regulator Mus musculus 95-99 11013125-6 2000 Forskolin, a stimulator of cyclic AMP, blocked TGF- beta induced CTGF expression and reduced the basal level of CTGF, whereas an inhibitor that blocks the MAP kinase signaling pathway (PD 98059) significantly enhanced TGF- beta induced CTGF expression. Colforsin 0-9 transforming growth factor beta 1 Homo sapiens 47-56 11013125-6 2000 Forskolin, a stimulator of cyclic AMP, blocked TGF- beta induced CTGF expression and reduced the basal level of CTGF, whereas an inhibitor that blocks the MAP kinase signaling pathway (PD 98059) significantly enhanced TGF- beta induced CTGF expression. Colforsin 0-9 cellular communication network factor 2 Homo sapiens 65-69 11013125-6 2000 Forskolin, a stimulator of cyclic AMP, blocked TGF- beta induced CTGF expression and reduced the basal level of CTGF, whereas an inhibitor that blocks the MAP kinase signaling pathway (PD 98059) significantly enhanced TGF- beta induced CTGF expression. Colforsin 0-9 cellular communication network factor 2 Homo sapiens 112-116 11013125-6 2000 Forskolin, a stimulator of cyclic AMP, blocked TGF- beta induced CTGF expression and reduced the basal level of CTGF, whereas an inhibitor that blocks the MAP kinase signaling pathway (PD 98059) significantly enhanced TGF- beta induced CTGF expression. Colforsin 0-9 transforming growth factor beta 1 Homo sapiens 218-227 11013125-6 2000 Forskolin, a stimulator of cyclic AMP, blocked TGF- beta induced CTGF expression and reduced the basal level of CTGF, whereas an inhibitor that blocks the MAP kinase signaling pathway (PD 98059) significantly enhanced TGF- beta induced CTGF expression. Colforsin 0-9 cellular communication network factor 2 Homo sapiens 112-116 11006079-3 2000 However, the magnitude of the forskolin-induced Isc, previously demonstrated to be mediated by CFTR, decreased as the amiloride sensitivity of the basal current increased, suggesting a possible inhibitory effect of elevated expression of ENaC on CFTR-mediated Cl(-) secretion. Colforsin 30-39 sodium channel, nonvoltage-gated 1 alpha Mus musculus 238-242 11006079-3 2000 However, the magnitude of the forskolin-induced Isc, previously demonstrated to be mediated by CFTR, decreased as the amiloride sensitivity of the basal current increased, suggesting a possible inhibitory effect of elevated expression of ENaC on CFTR-mediated Cl(-) secretion. Colforsin 30-39 cystic fibrosis transmembrane conductance regulator Mus musculus 246-250 11006079-5 2000 However, competitive RT-PCR demonstrated that the expression of both ENaC and CFTR was enhanced in Matrigel-treated culture, suggesting that the reduced forskolin-induced Isc with enhanced amiloride sensitivity was not due to a reduction in CFTR expression, but rather suppression of CFTR function by enhanced ENaC expression. Colforsin 153-162 sodium channel, nonvoltage-gated 1 alpha Mus musculus 69-73 11006079-5 2000 However, competitive RT-PCR demonstrated that the expression of both ENaC and CFTR was enhanced in Matrigel-treated culture, suggesting that the reduced forskolin-induced Isc with enhanced amiloride sensitivity was not due to a reduction in CFTR expression, but rather suppression of CFTR function by enhanced ENaC expression. Colforsin 153-162 cystic fibrosis transmembrane conductance regulator Mus musculus 78-82 10980241-3 2000 This effect was mimicked by co-treatment with a growth factor (aFGF, bFGF or BDNF; but not GDNF, IGF-1, EGF or TGF) and the neurotransmitter 5-HT (but not GABA, dopamine, glutamate) and/or a protein kinase activator (IBMX, forskolin, TPA). Colforsin 223-232 fibroblast growth factor 1 Homo sapiens 63-67 10862777-5 2000 Interestingly, the EGF-stimulated Raf kinase activity of the S43A mutant was inhibited by forskolin equivalently to that of the WT Raf. Colforsin 90-99 v-raf-leukemia viral oncogene 1 Mus musculus 34-37 10862777-6 2000 Forskolin also inhibited the activation of an N-terminal deletion mutant Delta5-50 Raf completely lacking this phosphorylation site. Colforsin 0-9 zinc fingers and homeoboxes 2 Homo sapiens 83-86 10862777-8 2000 In contrast, forskolin inhibited the EGF-dependent activation of a Raf isoform (B-Raf), lacking an analogous phosphorylation site to Ser(43). Colforsin 13-22 v-raf-leukemia viral oncogene 1 Mus musculus 67-70 10862777-8 2000 In contrast, forskolin inhibited the EGF-dependent activation of a Raf isoform (B-Raf), lacking an analogous phosphorylation site to Ser(43). Colforsin 13-22 Braf transforming gene Mus musculus 80-85 10980241-3 2000 This effect was mimicked by co-treatment with a growth factor (aFGF, bFGF or BDNF; but not GDNF, IGF-1, EGF or TGF) and the neurotransmitter 5-HT (but not GABA, dopamine, glutamate) and/or a protein kinase activator (IBMX, forskolin, TPA). Colforsin 223-232 fibroblast growth factor 2 Homo sapiens 69-73 10980241-3 2000 This effect was mimicked by co-treatment with a growth factor (aFGF, bFGF or BDNF; but not GDNF, IGF-1, EGF or TGF) and the neurotransmitter 5-HT (but not GABA, dopamine, glutamate) and/or a protein kinase activator (IBMX, forskolin, TPA). Colforsin 223-232 brain derived neurotrophic factor Homo sapiens 77-81 10967311-2 2000 Application of forskolin or dopamine to brain cells that were prelabeled with (32)Pi enhanced phosphorylation of a 25-kDa protein (p25a). Colforsin 15-24 jdp Drosophila melanogaster 131-135 10972959-2 2000 We report that chronic exposure of the serotonergic CNS cell line RN46A to cyclic AMP analogs, forskolin, or cholera toxin represses GAP-43 expression in a dose dependent manner. Colforsin 95-104 growth associated protein 43 Rattus norvegicus 133-139 10965903-4 2000 In contrast, glibenclamide enhanced forskolin- or CRH-induced POMC expression in a dose-dependent manner. Colforsin 36-45 pro-opiomelanocortin-alpha Mus musculus 62-66 10971817-3 2000 The secretion of both forms of GnRH was increased in a dependent manner during depolarization by high K+ solutions, and was stimulated by forskolin and 12-O-tetradecanoylphorbol-13-acetate (TPA), activators of adenylate cyclase and protein kinase C pathways, respectively. Colforsin 138-147 gonadotropin releasing hormone 1 Rattus norvegicus 31-35 10889186-6 2000 During screening of endogenous ligands for JULF2, we found that leukotriene B(4) induced inhibition of forskolin-stimulated cAMP accumulation in Chinese hamster ovary cells, stably expressing JULF2. Colforsin 103-112 leukotriene B4 receptor 2 Homo sapiens 43-48 10889186-6 2000 During screening of endogenous ligands for JULF2, we found that leukotriene B(4) induced inhibition of forskolin-stimulated cAMP accumulation in Chinese hamster ovary cells, stably expressing JULF2. Colforsin 103-112 leukotriene B4 receptor 2 Homo sapiens 192-197 10999829-12 2000 In contrast, BMP-4 decreased forskolin-stimulated HOTT cell secretion of androstenedione and 17OHP by 50% but increased progesterone production 3-fold above forskolin treatment alone. Colforsin 29-38 bone morphogenetic protein 4 Homo sapiens 13-18 10999829-12 2000 In contrast, BMP-4 decreased forskolin-stimulated HOTT cell secretion of androstenedione and 17OHP by 50% but increased progesterone production 3-fold above forskolin treatment alone. Colforsin 157-166 bone morphogenetic protein 4 Homo sapiens 13-18 10999829-13 2000 Forskolin treatment led to an increase in CYP17, CYP11A1, 3betaHSD, and StAR protein expression. Colforsin 0-9 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 42-47 10999829-13 2000 Forskolin treatment led to an increase in CYP17, CYP11A1, 3betaHSD, and StAR protein expression. Colforsin 0-9 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 49-56 10999829-13 2000 Forskolin treatment led to an increase in CYP17, CYP11A1, 3betaHSD, and StAR protein expression. Colforsin 0-9 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 58-66 10999829-13 2000 Forskolin treatment led to an increase in CYP17, CYP11A1, 3betaHSD, and StAR protein expression. Colforsin 0-9 steroidogenic acute regulatory protein Homo sapiens 72-76 10999829-14 2000 BMP-4 markedly inhibited forskolin stimulation of CYP17 expression but had little effect on 3betaHSD, CYP11A1, or StAR protein levels. Colforsin 25-34 bone morphogenetic protein 4 Homo sapiens 0-5 10999829-14 2000 BMP-4 markedly inhibited forskolin stimulation of CYP17 expression but had little effect on 3betaHSD, CYP11A1, or StAR protein levels. Colforsin 25-34 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 50-55 10999829-16 2000 In addition, BMP-4 inhibited basal and forskolin stimulation of CYP17 messenger RNA expression as determined by RNase protection assay. Colforsin 39-48 bone morphogenetic protein 4 Homo sapiens 13-18 10999829-16 2000 In addition, BMP-4 inhibited basal and forskolin stimulation of CYP17 messenger RNA expression as determined by RNase protection assay. Colforsin 39-48 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-69 10999829-18 2000 In the presence of forskolin, activin inhibited androstenedione production by 80%. Colforsin 19-28 inhibin subunit beta E Homo sapiens 30-37 10999829-19 2000 Activin also inhibited forskolin induction of CYP17 protein expression as determined by Western analysis. Colforsin 23-32 inhibin subunit beta E Homo sapiens 0-7 10999829-19 2000 Activin also inhibited forskolin induction of CYP17 protein expression as determined by Western analysis. Colforsin 23-32 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 46-51 11043449-4 2000 Forskolin was able to mimic the Ca2+ response to ISO. Colforsin 0-9 carbonic anhydrase 2 Rattus norvegicus 32-35 11043449-6 2000 In the absence of extracellular Ca2+, ISO or forskolin caused a transient increase in [Ca2+]i, indicating Ca2+ mobilization from intracellular Ca2+ stores. Colforsin 45-54 carbonic anhydrase 2 Rattus norvegicus 87-90 10980416-5 2000 The increased transcription was mimicked by both forskolin (10(-6) M) and isoproterenol (10(-7) M), and was also increased by 3-isobutyl-1-methylxanthine (IBMX; 10(-5) M), while the transcriptional activity induced by PTH was inhibited by the protein kinase A inhibitor, H89 (5x10(-6) M). Colforsin 49-58 parathyroid hormone Rattus norvegicus 218-221 10980416-8 2000 Binding of a nuclear protein, recognized by anti-Pit-1 antibodies, to a radiolabelled Pit-1-BSP probe was decreased in nuclear extracts prepared from PTH, forskolin and isoproterenol-stimulated ROS 17/2.8 cells. Colforsin 155-164 POU class 1 homeobox 1 Rattus norvegicus 49-54 10980416-8 2000 Binding of a nuclear protein, recognized by anti-Pit-1 antibodies, to a radiolabelled Pit-1-BSP probe was decreased in nuclear extracts prepared from PTH, forskolin and isoproterenol-stimulated ROS 17/2.8 cells. Colforsin 155-164 POU class 1 homeobox 1 Rattus norvegicus 86-91 10980416-8 2000 Binding of a nuclear protein, recognized by anti-Pit-1 antibodies, to a radiolabelled Pit-1-BSP probe was decreased in nuclear extracts prepared from PTH, forskolin and isoproterenol-stimulated ROS 17/2.8 cells. Colforsin 155-164 integrin-binding sialoprotein Rattus norvegicus 92-95 11043449-6 2000 In the absence of extracellular Ca2+, ISO or forskolin caused a transient increase in [Ca2+]i, indicating Ca2+ mobilization from intracellular Ca2+ stores. Colforsin 45-54 carbonic anhydrase 2 Rattus norvegicus 87-90 11043449-6 2000 In the absence of extracellular Ca2+, ISO or forskolin caused a transient increase in [Ca2+]i, indicating Ca2+ mobilization from intracellular Ca2+ stores. Colforsin 45-54 carbonic anhydrase 2 Rattus norvegicus 87-90 10981712-8 2000 Rabbit portal vein telokin was phosphorylated on both Ser-13 and -19 as a result of forskolin and GTPgammaS stimulation in vivo. Colforsin 84-93 myosin light chain kinase, smooth muscle Oryctolagus cuniculus 19-26 10953055-8 2000 Forskolin, a direct activator of adenylyl cyclase, inhibited CCK- and EGF-induced activation of c-Raf-1 and ERK1/2 in a manner similar to that of PTx. Colforsin 0-9 cholecystokinin Rattus norvegicus 61-64 10953055-8 2000 Forskolin, a direct activator of adenylyl cyclase, inhibited CCK- and EGF-induced activation of c-Raf-1 and ERK1/2 in a manner similar to that of PTx. Colforsin 0-9 epidermal growth factor Rattus norvegicus 70-73 10953055-8 2000 Forskolin, a direct activator of adenylyl cyclase, inhibited CCK- and EGF-induced activation of c-Raf-1 and ERK1/2 in a manner similar to that of PTx. Colforsin 0-9 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 96-101 10953055-8 2000 Forskolin, a direct activator of adenylyl cyclase, inhibited CCK- and EGF-induced activation of c-Raf-1 and ERK1/2 in a manner similar to that of PTx. Colforsin 0-9 mitogen activated protein kinase 3 Rattus norvegicus 108-114 11108142-2 2000 To test whether the transcription factor CREB is in the pathway involved in modulation of AT1-receptor gene expression, AT1 receptor mRNA levels were measured after stimulation with forskolin, angiotensin II and PDGF-BB in VSMC expressing the inducible cAMP early repressor protein, ICERIIgamma, fused to the green fluorescent protein (eGFP). Colforsin 182-191 cAMP responsive element binding protein 1 Rattus norvegicus 41-45 10862764-10 2000 This difference may be explained in part by a lesser forskolin-induced increase in glycogen phosphorylase activity in PTG-overexpressing cells. Colforsin 53-62 protein phosphatase 1, regulatory subunit 3C Rattus norvegicus 118-121 10964727-6 2000 The potency and the efficacy of MCH were significantly increased in the simultaneous presence of forskolin, suggesting that MCH may amplify the insulinotropic effect of cyclic AMP elevating stimuli. Colforsin 97-106 pro-melanin concentrating hormone Homo sapiens 32-35 10964727-6 2000 The potency and the efficacy of MCH were significantly increased in the simultaneous presence of forskolin, suggesting that MCH may amplify the insulinotropic effect of cyclic AMP elevating stimuli. Colforsin 97-106 pro-melanin concentrating hormone Homo sapiens 124-127 10926834-4 2000 Treatment of the cells with forskolin or dibutyryl-cAMP attenuated the expression of M-CSF induced by IL-1alpha or LPS, but not by PMA. Colforsin 28-37 colony stimulating factor 1 Homo sapiens 85-90 10960153-11 2000 In intact mIMCD-K2 layers in Ussing chambers, forskolin stimulation of an inward short-circuit current (due to transepithelial Cl(-) secretion via apical CFTR) was inhibited by cell swelling upon hypotonic exposure at the basolateral surface. Colforsin 46-55 cystic fibrosis transmembrane conductance regulator Mus musculus 154-158 10926834-4 2000 Treatment of the cells with forskolin or dibutyryl-cAMP attenuated the expression of M-CSF induced by IL-1alpha or LPS, but not by PMA. Colforsin 28-37 interleukin 1 alpha Homo sapiens 102-111 10983847-2 2000 The intrinsic activity of the compounds was also evaluated by measuring the inhibition of forskolin-stimulated 3"-5"-cyclic adenosine monophosphate (c-AMP) levels in isolated epididymal rat adipocytes. Colforsin 90-99 cathelicidin antimicrobial peptide Rattus norvegicus 149-154 10924347-3 2000 ACTH also induced ACS4 protein but not its mRNA in Y1 adrenocortical tumor cells, whereas both ACS4 mRNA and protein were increased by dibutyryl cAMP (db-cAMP) and forskolin. Colforsin 164-173 acyl-CoA synthetase long chain family member 4 Homo sapiens 95-99 10913004-0 2000 Forskolin-induced apical membrane insertion of virally expressed, epitope-tagged CFTR in polarized MDCK cells. Colforsin 0-9 CF transmembrane conductance regulator Canis lupus familiaris 81-85 10913004-6 2000 We have developed replication-defective recombinant adenoviruses that express M2-901/CFTR and used them to probe cell surface CFTR in forskolin (FSK)-stimulated polarized Madin-Darby canine kidney (MDCK) cells. Colforsin 134-143 CF transmembrane conductance regulator Canis lupus familiaris 126-130 10913004-6 2000 We have developed replication-defective recombinant adenoviruses that express M2-901/CFTR and used them to probe cell surface CFTR in forskolin (FSK)-stimulated polarized Madin-Darby canine kidney (MDCK) cells. Colforsin 145-148 CF transmembrane conductance regulator Canis lupus familiaris 126-130 10913004-7 2000 Virally expressed M2-901/CFTR was functional and was readily detected on the apical surface of FSK-stimulated polarized MDCK cells. Colforsin 95-98 CF transmembrane conductance regulator Canis lupus familiaris 25-29 10913004-8 2000 Interestingly, at low multiplicity of infection, we observed FSK-stimulated insertion of M2901/CFTR into the apical PM, whereas at higher M2-901/CFTR expression levels, no increase in surface expression was detected using indirect immunofluorescence. Colforsin 61-64 CF transmembrane conductance regulator Canis lupus familiaris 95-99 10913004-9 2000 Immunoelectron microscopy of unstimulated and FSK-stimulated cells confirmed the M2-901/CFTR redistribution to the PM upon FSK stimulation and demonstrates that the apically inserted M2-901/CFTR originates from a population of subapical vesicles. Colforsin 46-49 CF transmembrane conductance regulator Canis lupus familiaris 88-92 10913004-9 2000 Immunoelectron microscopy of unstimulated and FSK-stimulated cells confirmed the M2-901/CFTR redistribution to the PM upon FSK stimulation and demonstrates that the apically inserted M2-901/CFTR originates from a population of subapical vesicles. Colforsin 46-49 CF transmembrane conductance regulator Canis lupus familiaris 190-194 10913004-9 2000 Immunoelectron microscopy of unstimulated and FSK-stimulated cells confirmed the M2-901/CFTR redistribution to the PM upon FSK stimulation and demonstrates that the apically inserted M2-901/CFTR originates from a population of subapical vesicles. Colforsin 123-126 CF transmembrane conductance regulator Canis lupus familiaris 88-92 10856433-7 2000 In contrast, PDE4 inhibitors increased the forskolin-induced cellular cAMP concentration 13- to 17-fold above control. Colforsin 43-52 phosphodiesterase 4A Homo sapiens 13-17 10856433-7 2000 In contrast, PDE4 inhibitors increased the forskolin-induced cellular cAMP concentration 13- to 17-fold above control. Colforsin 43-52 cathelicidin antimicrobial peptide Homo sapiens 70-74 10919863-6 2000 After forskolin stimulation, the endogenous adenylyl cyclase in C6-2B glioma cells produced high concentrations of cAMP near the channels, yet the global cAMP concentration remained low. Colforsin 6-15 cathelicidin antimicrobial peptide Mus musculus 115-119 10972167-6 2000 Stimulation of PKA activity was also seen with forskolin and di-butyryl cAMP. Colforsin 47-56 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 15-18 10971617-3 2000 Forskolin treatment and depolarization with potassium plus BayK 8644 led to significant increases in secretogranin II mRNA in the principal cells of the hippocampus. Colforsin 0-9 secretogranin II Rattus norvegicus 101-117 10971617-6 2000 Both forskolin and depolarization upregulated the prohormone convertase (PC)1, but not PC2, indicating that PC1 levels are critical for secretoneurin production under stimulating conditions. Colforsin 5-14 proprotein convertase subtilisin/kexin type 1 Rattus norvegicus 50-77 10971617-6 2000 Both forskolin and depolarization upregulated the prohormone convertase (PC)1, but not PC2, indicating that PC1 levels are critical for secretoneurin production under stimulating conditions. Colforsin 5-14 proprotein convertase subtilisin/kexin type 1 Rattus norvegicus 108-111 10922990-5 2000 After reperfusion, the relaxation responses to isoproterenol and forskolin after K-CP were significantly reduced (both P <.05 vs control) but were preserved after PCO-CP. Colforsin 65-74 kielin cysteine rich BMP regulator Rattus norvegicus 81-85 10915219-9 2000 Octreotide (10(-6) and 10(-7) M) significantly decreased (P<0.001) forskolin-induced but not basal cAMP accumulation; at both doses for 72 h it inhibited cell growth (20 and 55% respectively), and induced apoptosis (20 and 40%), and abolished Bcl-2 protein in cell lysates. Colforsin 70-79 BCL2 apoptosis regulator Homo sapiens 246-251 10899967-4 2000 Combined treatment with forskolin and elevated potassium significantly increased expression of both endogenous PPT mRNA and the PPT promoter-GFP construct. Colforsin 24-33 tachykinin, precursor 1 Rattus norvegicus 111-114 10899967-4 2000 Combined treatment with forskolin and elevated potassium significantly increased expression of both endogenous PPT mRNA and the PPT promoter-GFP construct. Colforsin 24-33 tachykinin, precursor 1 Rattus norvegicus 128-131 10900076-6 2000 Treatment of raphe neurons with forskolin induced BDNF mRNA assayed by competitive RT-PCR. Colforsin 32-41 brain-derived neurotrophic factor Rattus norvegicus 50-54 10900076-7 2000 Moreover, trkB-IgG receptor bodies fully prevented the forskolin-induced numerical increase in TpOH- and 5,7-DHT-positive cells suggesting an implication of a TrkB-activated pathway. Colforsin 55-64 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 10-14 10900076-7 2000 Moreover, trkB-IgG receptor bodies fully prevented the forskolin-induced numerical increase in TpOH- and 5,7-DHT-positive cells suggesting an implication of a TrkB-activated pathway. Colforsin 55-64 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 159-163 10900076-9 2000 K252b, a specific inhibitor of trk kinase activity likewise abolished the induction of serotonergic markers by forskolin. Colforsin 111-120 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 31-34 10908604-3 2000 cAMP analogs and the adenylyl cyclase activator forskolin inhibit the function of presynaptic group II mGluRs in area CA3 of the hippocampus. Colforsin 48-57 carbonic anhydrase 3 Homo sapiens 118-121 10908604-4 2000 We now report that forskolin has a similar inhibitory effect on putative mGluR2-mediated responses at the medial perforant path synapse and that this effect of forskolin is blocked by a selective inhibitor of cAMP-dependent protein kinase (PKA). Colforsin 19-28 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 73-79 10908604-4 2000 We now report that forskolin has a similar inhibitory effect on putative mGluR2-mediated responses at the medial perforant path synapse and that this effect of forskolin is blocked by a selective inhibitor of cAMP-dependent protein kinase (PKA). Colforsin 160-169 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 73-79 11354927-6 2000 While little NO was released from articular chondrocytes in the presence of PGE2 or direct adenylate cyclase activator such as forskolin, synergistic augmentation of NO generation was observed when chondrocytes were stimulated by PGE2 or forskolin in combination with IL-1 alpha. Colforsin 127-136 interleukin 1 alpha Bos taurus 268-278 10930508-3 2000 Inhibition of forskolin-stimulated chloride secretion, as measured by the short-circuit current (Isc) technique, had an IC50 of 200-500 nM, which is 100-fold higher than for inhibition of phosphatidylinositol 3-kinase (PI3K), but similar to the IC50 for inhibition of myosin light chain kinase (MLCK) and mitogen-activated protein kinases (MAPK). Colforsin 14-23 myosin light chain kinase Homo sapiens 268-293 10770951-4 2000 Forskolin induced Erk1/2 activation similarly to beta(3) activation, indicating cAMP-mediation; this induction could be inhibited with H89, implying protein kinase A mediation. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 18-24 10930508-3 2000 Inhibition of forskolin-stimulated chloride secretion, as measured by the short-circuit current (Isc) technique, had an IC50 of 200-500 nM, which is 100-fold higher than for inhibition of phosphatidylinositol 3-kinase (PI3K), but similar to the IC50 for inhibition of myosin light chain kinase (MLCK) and mitogen-activated protein kinases (MAPK). Colforsin 14-23 myosin light chain kinase Homo sapiens 295-299 10915841-3 2000 The modulatory and relaxant effects of dibutyryl cyclic AMP, NECA and forskolin were sensitive to the protein kinase A inhibitor, Rp-cAMPS. Colforsin 70-79 calmodulin 2, pseudogene 1 Rattus norvegicus 133-138 10806197-4 2000 We confirmed that adenylate cyclase activation by forskolin results in diminished O-GlcNAc modification of several cellular proteins which can be overcome by exposure of the cells to glucosamine but not glucose, suggesting the PKA activation results in depletion of UDP-GlcNAc for O-glycosylation. Colforsin 50-59 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 82-90 10801894-9 2000 However, the Raf inhibitor forskolin blocked ERK activation by H(2)O(2), but not by ONOO(-). Colforsin 27-36 Eph receptor B1 Rattus norvegicus 45-48 10908723-2 2000 Using this procedure we demonstrate that the cyclic AMP-elevating agent forskolin activates both Rap1A and Rap1B in Rat1 cells. Colforsin 72-81 RAP1A, member of RAS oncogene family Rattus norvegicus 97-102 10908723-0 2000 Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells. Colforsin 114-123 RAP1A, member of RAS oncogene family Rattus norvegicus 49-54 10903915-4 2000 We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate NF-kappaB, AP-1, and CREB activation induced by TNFalpha, PMA, and forskolin and by expression of signaling intermediate kinases, NIK, MEKK, and PKA in HEK293 cells. Colforsin 221-230 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 165-169 10903915-4 2000 We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate NF-kappaB, AP-1, and CREB activation induced by TNFalpha, PMA, and forskolin and by expression of signaling intermediate kinases, NIK, MEKK, and PKA in HEK293 cells. Colforsin 221-230 cAMP responsive element binding protein 1 Homo sapiens 175-179 10908723-2 2000 Using this procedure we demonstrate that the cyclic AMP-elevating agent forskolin activates both Rap1A and Rap1B in Rat1 cells. Colforsin 72-81 RAP1B, member of RAS oncogene family Rattus norvegicus 107-112 10908723-0 2000 Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells. Colforsin 114-123 RAP1B, member of RAS oncogene family Rattus norvegicus 59-64 10908723-3 2000 Whilst the protein kinase A inhibitor H89 ablated the ability of forskolin to cause cAMP response element binding protein (CREB) phosphorylation in Rat1 cells, it did not affect the ability of forskolin to activate either Rap1A and Rap1B. Colforsin 65-74 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 11-27 10908723-3 2000 Whilst the protein kinase A inhibitor H89 ablated the ability of forskolin to cause cAMP response element binding protein (CREB) phosphorylation in Rat1 cells, it did not affect the ability of forskolin to activate either Rap1A and Rap1B. Colforsin 65-74 cAMP responsive element binding protein 1 Rattus norvegicus 84-121 10908723-3 2000 Whilst the protein kinase A inhibitor H89 ablated the ability of forskolin to cause cAMP response element binding protein (CREB) phosphorylation in Rat1 cells, it did not affect the ability of forskolin to activate either Rap1A and Rap1B. Colforsin 65-74 cAMP responsive element binding protein 1 Rattus norvegicus 123-127 10908723-4 2000 Forskolin differentially activated Rap1A and Rap1B isoforms in a time- and dose-dependent manner. Colforsin 0-9 RAP1A, member of RAS oncogene family Rattus norvegicus 35-40 10908723-4 2000 Forskolin differentially activated Rap1A and Rap1B isoforms in a time- and dose-dependent manner. Colforsin 0-9 RAP1B, member of RAS oncogene family Rattus norvegicus 45-50 10908723-5 2000 The cAMP-specific type 4 family phosphodiesterase inhibitor rolipram potentiated the rate of activation of both Rap1A and Rap1B by forskolin challenge of Rat1 cells. Colforsin 131-140 RAP1A, member of RAS oncogene family Rattus norvegicus 112-117 10908723-5 2000 The cAMP-specific type 4 family phosphodiesterase inhibitor rolipram potentiated the rate of activation of both Rap1A and Rap1B by forskolin challenge of Rat1 cells. Colforsin 131-140 RAP1B, member of RAS oncogene family Rattus norvegicus 122-127 10869820-4 2000 Application of Bt(2)-cAMP and forskolin increased the promoter driven luciferase activity over 2-fold in the transfected NG108-15 cells; the increase was parallel to the activation of endogenous AChE protein and enzymatic activity. Colforsin 30-39 acetylcholinesterase Mus musculus 195-199 10875233-8 2000 In addition, 10 microM phorbol ester or forskolin treatments resulted in a significant increase in GnRHR expression in both JEG-3 and IEVT cells. Colforsin 40-49 gonadotropin releasing hormone receptor Homo sapiens 99-104 10893328-9 2000 In islets from L-NAME-drinking mice, cyclic nucleotides were upregulated, and forskolin-stimulated hormone release, CO production, and heme oxygenase (HO)-2 expression increased. Colforsin 78-87 heme oxygenase 2 Mus musculus 135-156 10898738-4 2000 Expression of the VACM-1 gene reduced basal as well as forskolin- and AVP-stimulated cAMP production. Colforsin 55-64 cullin 5 Homo sapiens 18-24 10898738-5 2000 In cells cotransfected with VACM-1 and the V(2) receptor, the AVP- and forskolin-induced increases in adenylyl cyclase activity and cAMP production were inhibited. Colforsin 71-80 cullin 5 Homo sapiens 28-34 10873156-4 2000 TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP. Colforsin 194-197 tumor necrosis factor Homo sapiens 0-9 10873156-4 2000 TNF-alpha (10 ng/ml)-induced IL-8 release was markedly inhibited by the steroids dexamethasone (Dex) (0.1 to 10 microM) and fluticasone (Flut) (0.01 to 1 microM) but unaffected by Salbu, Salme, FSK, or 8-Br-cAMP. Colforsin 194-197 C-X-C motif chemokine ligand 8 Homo sapiens 29-33 10898715-5 2000 ClC-2 Cl(-) channels were activated by a combination of forskolin plus IBMX and were inhibited by the cell-permeant myristoylated PKA inhibitor (mPKI). Colforsin 56-65 chloride voltage-gated channel 2 Homo sapiens 0-5 10903977-4 2000 The ability of PGE(2), dbcAMP, rolipram, forskolin, dbcGMP and PGD(2), to modulate the responses to GM-CSF and IL-5 in colony formation (progenitor) and eosinophil differentiation (precursor) assays using bone-marrow from nonsensitized or from intranasally-challenged, ovalbumin-sensitized mice of five strains was studied. Colforsin 41-50 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 100-106 10903977-4 2000 The ability of PGE(2), dbcAMP, rolipram, forskolin, dbcGMP and PGD(2), to modulate the responses to GM-CSF and IL-5 in colony formation (progenitor) and eosinophil differentiation (precursor) assays using bone-marrow from nonsensitized or from intranasally-challenged, ovalbumin-sensitized mice of five strains was studied. Colforsin 41-50 interleukin 5 Mus musculus 111-115 10874508-0 2000 Effects of NKH477 on endothelin-1-induced renal responses in anaesthetized dogs. Colforsin 11-17 endothelin 1 Canis lupus familiaris 21-33 10874508-4 2000 Intrarenal arterial infusion of endothelin (ET)-1 (2 ng/kg per min) reduced basal values of these parameters and glomerular filtration rate, which were recovered by the addition of NKH477 during ET-1 infusion. Colforsin 181-187 endothelin 1 Canis lupus familiaris 32-42 10909970-3 2000 Quantitative competitive reverse transcriptase-polymerase chain reaction revealed that an increase of cellular cAMP mediated by forskolin (10 micromol/l, 24 h) or 3-isobutyl-1-methylxanthine (100 micromol/l, 24 h) induced maximal stimulation of IA-2 mRNA levels (451 +/- 85 and 338 +/- 86% compared with basal conditions; P < 0.001). Colforsin 128-137 protein tyrosine phosphatase, receptor type, N Rattus norvegicus 245-249 10816606-6 2000 Indeed, the cAMP agonist forskolin increased the binding of the transcription factors NF-IL-6 and C/EBPdelta to the CAAT box of the IL-6 promoter in nuclear extracts of astrocytes. Colforsin 25-34 CCAAT enhancer binding protein beta Homo sapiens 86-93 10816606-6 2000 Indeed, the cAMP agonist forskolin increased the binding of the transcription factors NF-IL-6 and C/EBPdelta to the CAAT box of the IL-6 promoter in nuclear extracts of astrocytes. Colforsin 25-34 CCAAT enhancer binding protein delta Homo sapiens 98-108 10816606-6 2000 Indeed, the cAMP agonist forskolin increased the binding of the transcription factors NF-IL-6 and C/EBPdelta to the CAAT box of the IL-6 promoter in nuclear extracts of astrocytes. Colforsin 25-34 interleukin 6 Homo sapiens 89-93 10816606-7 2000 Inhibition of the de novo synthesis of NF-IL-6 by cycloheximide or an antisense oligonucleotide reduced the enhancement of NF-IL-6 binding to the CAAT box and inhibited stimulation of IL-6 transcription by forskolin. Colforsin 206-215 CCAAT enhancer binding protein beta Homo sapiens 39-46 10816606-7 2000 Inhibition of the de novo synthesis of NF-IL-6 by cycloheximide or an antisense oligonucleotide reduced the enhancement of NF-IL-6 binding to the CAAT box and inhibited stimulation of IL-6 transcription by forskolin. Colforsin 206-215 CCAAT enhancer binding protein beta Homo sapiens 123-130 10816606-7 2000 Inhibition of the de novo synthesis of NF-IL-6 by cycloheximide or an antisense oligonucleotide reduced the enhancement of NF-IL-6 binding to the CAAT box and inhibited stimulation of IL-6 transcription by forskolin. Colforsin 206-215 interleukin 6 Homo sapiens 42-46 12659167-4 2000 Fractionation of media obtained from cells stimulated with nicotine reveals an NPY-like substance that inhibits FSK-stimulated cAMP accumulation. Colforsin 112-115 neuropeptide Y Bos taurus 79-82 11039498-7 2000 A maximum increase of 40-50% in the quantity of MHC was observed at 0.2 microM forskolin, but higher concentrations of forskolin reduced the quantity of MHC back to control levels. Colforsin 79-88 myosin, heavy chain 15 Gallus gallus 48-51 11039498-7 2000 A maximum increase of 40-50% in the quantity of MHC was observed at 0.2 microM forskolin, but higher concentrations of forskolin reduced the quantity of MHC back to control levels. Colforsin 119-128 myosin, heavy chain 15 Gallus gallus 153-156 10861802-2 2000 In 5HT(5a) receptor-transfected cells, 5HT caused a concentration-dependent inhibition of forskolin-stimulated cAMP accumulation, with an EC(50) value of 41 nM and a maximal effect of 57% inhibition. Colforsin 90-99 5-hydroxytryptamine receptor 5A Rattus norvegicus 3-9 10860936-4 2000 We found that elevation of intracellular cAMP by forskolin abolishes epidermal growth factor (EGF)- or scatter factor/hepatocyte growth factor-dependent colony dispersion. Colforsin 49-58 epidermal growth factor Homo sapiens 94-97 10860936-5 2000 Concentrations of forskolin that inhibit growth factor-induced motility also eliminate EGF- or scatter factor/hepatocyte growth factor-dependent induction of the 92-kDa gelatinase/MMP-9. Colforsin 18-27 epidermal growth factor Homo sapiens 87-90 10860936-5 2000 Concentrations of forskolin that inhibit growth factor-induced motility also eliminate EGF- or scatter factor/hepatocyte growth factor-dependent induction of the 92-kDa gelatinase/MMP-9. Colforsin 18-27 matrix metallopeptidase 9 Homo sapiens 180-185 10860936-7 2000 However, forskolin effectively inhibited EGF-dependent activation of c-Jun N-terminal kinase and p38, demonstrating that cAMP selectively interferes with a different subset of growth factor-induced mitogen-activated protein kinase signaling cascades than reported previously in fibroblasts. Colforsin 9-18 epidermal growth factor Homo sapiens 41-44 10860936-7 2000 However, forskolin effectively inhibited EGF-dependent activation of c-Jun N-terminal kinase and p38, demonstrating that cAMP selectively interferes with a different subset of growth factor-induced mitogen-activated protein kinase signaling cascades than reported previously in fibroblasts. Colforsin 9-18 mitogen-activated protein kinase 14 Homo sapiens 97-100 10940738-5 2000 ERK activation was mimicked by cholera toxin, forskolin and 8bromo-cAMP. Colforsin 46-55 Eph receptor B1 Rattus norvegicus 0-3 10873606-3 2000 Previous results from our laboratory demonstrated that water channel activity of AQP1 was significantly increased by protein kinase A (PKA) activators such as cyclic-AMP (cAMP) and forskolin. Colforsin 181-190 aquaporin 1 (Colton blood group) Homo sapiens 81-85 10880128-8 2000 Finally, cotransfection studies demonstrated that PLP-GFP, but not DM20-GFP mRNA is down-regulated in Schwann cells cultured in the absence of forskolin. Colforsin 143-152 proteolipid protein 1 Homo sapiens 50-53 10873559-5 2000 Exposure of Y1 cells to forskolin significantly increased the expression of StAR mRNA and this forskolin-induced increase was reduced after exposure to Cal A at levels similar to those seen in the controls. Colforsin 24-33 steroidogenic acute regulatory protein Homo sapiens 76-80 10873559-5 2000 Exposure of Y1 cells to forskolin significantly increased the expression of StAR mRNA and this forskolin-induced increase was reduced after exposure to Cal A at levels similar to those seen in the controls. Colforsin 95-104 steroidogenic acute regulatory protein Homo sapiens 76-80 12659167-5 2000 Thus, an NPY-like substance can be secreted from bovine chromaffin cells in quantities sufficient to inhibit FSK-stimulated cAMP accumulation. Colforsin 109-112 neuropeptide Y Bos taurus 9-12 10843754-3 2000 In a B-cell line that fails to elevate cAMP, attenuate NRE-binding protein (NRE-BP) activity or express CD25 following IL-4 treatment, stimulation of cAMP accumulation by forskolin facilitates IL-4-mediated induction of both the endogenous gene and an exogenous reporter gene under the control of a minimal promoter/enhancer fragment of the CD25 gene. Colforsin 171-180 SON DNA and RNA binding protein Homo sapiens 55-74 10844032-4 2000 Levels of CDK2 protein were elevated in proliferating Schwann cells cultured in serum and forskolin. Colforsin 90-99 cyclin dependent kinase 2 Homo sapiens 10-14 10830310-6 2000 The increases in PRL release induced in vitro by drugs that signal via cAMP/protein kinase A [vasoactive intestinal polypeptide (10 nM), forskolin (100 microM), 8-bromo-cAMP (0.1 microM)] or phospholipase C (TRH, 10 nM) were attenuated by preincubation of the pituitary tissue with either corticosterone (1 nM) or dexamethasone (100 nM). Colforsin 137-146 prolactin Rattus norvegicus 17-20 10830310-7 2000 The inhibitory actions of the steroids on the secretory responses to vasoactive intestinal polypeptide, forskolin, and 8-bromo-cAMP were specifically quenched by inclusion in the medium of the annexin 1 antisense ODN (50 nM) or a neutralizing antiannexin 1 monoclonal antibody (antiannexin 1 mAb, diluted 1:15,000). Colforsin 104-113 annexin A1 Rattus norvegicus 193-202 10848707-8 2000 Direct stimulation of protein kinase C (PKC) by phorbol ester (33 ng/mL) or elevation of cAMP using forskolin (10 micromol/L) increased NGF, suggesting that at least two intracellular pathways (PKC- and PKA-dependent) are involved. Colforsin 100-109 nerve growth factor Homo sapiens 136-139 10866046-7 2000 Costimulation of the beta-cell by TPA and forskolin induced drastic translocation of insulin granules and MLCK to the cell periphery, resulting in enormous potentiation of insulin release. Colforsin 42-51 myosin light chain kinase 3 Mus musculus 106-110 10843754-3 2000 In a B-cell line that fails to elevate cAMP, attenuate NRE-binding protein (NRE-BP) activity or express CD25 following IL-4 treatment, stimulation of cAMP accumulation by forskolin facilitates IL-4-mediated induction of both the endogenous gene and an exogenous reporter gene under the control of a minimal promoter/enhancer fragment of the CD25 gene. Colforsin 171-180 SON DNA and RNA binding protein Homo sapiens 76-82 10843754-3 2000 In a B-cell line that fails to elevate cAMP, attenuate NRE-binding protein (NRE-BP) activity or express CD25 following IL-4 treatment, stimulation of cAMP accumulation by forskolin facilitates IL-4-mediated induction of both the endogenous gene and an exogenous reporter gene under the control of a minimal promoter/enhancer fragment of the CD25 gene. Colforsin 171-180 interleukin 2 receptor subunit alpha Homo sapiens 104-108 10843754-3 2000 In a B-cell line that fails to elevate cAMP, attenuate NRE-binding protein (NRE-BP) activity or express CD25 following IL-4 treatment, stimulation of cAMP accumulation by forskolin facilitates IL-4-mediated induction of both the endogenous gene and an exogenous reporter gene under the control of a minimal promoter/enhancer fragment of the CD25 gene. Colforsin 171-180 interleukin 4 Homo sapiens 119-123 10843754-3 2000 In a B-cell line that fails to elevate cAMP, attenuate NRE-binding protein (NRE-BP) activity or express CD25 following IL-4 treatment, stimulation of cAMP accumulation by forskolin facilitates IL-4-mediated induction of both the endogenous gene and an exogenous reporter gene under the control of a minimal promoter/enhancer fragment of the CD25 gene. Colforsin 171-180 interleukin 4 Homo sapiens 193-197 10843754-3 2000 In a B-cell line that fails to elevate cAMP, attenuate NRE-binding protein (NRE-BP) activity or express CD25 following IL-4 treatment, stimulation of cAMP accumulation by forskolin facilitates IL-4-mediated induction of both the endogenous gene and an exogenous reporter gene under the control of a minimal promoter/enhancer fragment of the CD25 gene. Colforsin 171-180 interleukin 2 receptor subunit alpha Homo sapiens 341-345 10843764-6 2000 IFN-gamma also synergistically augmented HGF production induced by interleukin-1beta and cAMP-increasing agents cholera toxin, forskolin and prostaglandin E(2). Colforsin 127-136 interferon gamma Homo sapiens 0-9 10843764-6 2000 IFN-gamma also synergistically augmented HGF production induced by interleukin-1beta and cAMP-increasing agents cholera toxin, forskolin and prostaglandin E(2). Colforsin 127-136 hepatocyte growth factor Homo sapiens 41-44 10843764-6 2000 IFN-gamma also synergistically augmented HGF production induced by interleukin-1beta and cAMP-increasing agents cholera toxin, forskolin and prostaglandin E(2). Colforsin 127-136 cathelicidin antimicrobial peptide Homo sapiens 89-93 10843764-7 2000 HGF gene expression upregulated by cholera toxin, forskolin and 8-bromo-cAMP was markedly enhanced by IFN-gamma, which was detected as early as 3 h after its addition. Colforsin 50-59 hepatocyte growth factor Homo sapiens 0-3 10806109-4 2000 In intact cells, in vivo phosphorylation studies revealed that forskolin stimulation resulted in a threefold increase in AQP2 phosphorylation. Colforsin 63-72 aquaporin 2 Homo sapiens 121-125 10898514-4 2000 A rapid effect of forskolin was noted on the activity of cyclin-dependent kinase (cdk) 4, which decreased significantly within 30 min of treatment. Colforsin 18-27 cyclin dependent kinase 4 Homo sapiens 57-88 10804193-7 2000 Moreover, at 14 DIV, but not at 7 DIV, NMDA receptor stimulation induced a dephosphorylation of CREB that previously had been phosphorylated by KCl depolarization or forskolin, suggesting an NMDA receptor-dependent activation of a CREB phosphatase. Colforsin 166-175 cAMP responsive element binding protein 1 Homo sapiens 96-100 10852468-4 2000 Cotransfection of a steroidogenic factor-1 expression plasmid was found to be required for detection of basal and forskolin-stimulated CYP17 promoter activity but not for StAR promoter activity. Colforsin 114-123 nuclear receptor subfamily 5 group A member 1 Homo sapiens 20-42 10852468-4 2000 Cotransfection of a steroidogenic factor-1 expression plasmid was found to be required for detection of basal and forskolin-stimulated CYP17 promoter activity but not for StAR promoter activity. Colforsin 114-123 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 135-140 10852468-5 2000 However, cotransfection with a steroidogenic factor-1 expression plasmid augmented both basal and forskolin-stimulated StAR promoter activity. Colforsin 98-107 nuclear receptor subfamily 5 group A member 1 Homo sapiens 31-53 10852468-5 2000 However, cotransfection with a steroidogenic factor-1 expression plasmid augmented both basal and forskolin-stimulated StAR promoter activity. Colforsin 98-107 steroidogenic acute regulatory protein Homo sapiens 119-123 10852468-7 2000 Basal and forskolin-stimulated CYP17 promoter activity was 4-fold greater in PCOS cells than in theca cells isolated from normal ovaries. Colforsin 10-19 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 31-36 10888256-7 2000 The levels of VEGF mRNA in CEVM were significantly augmented by forskolin (100 microM), or phorbol 12-myristate, 13-acetate (200 nM) in a time-dependent manner in CEVM. Colforsin 64-73 vascular endothelial growth factor A Gallus gallus 14-18 10825384-7 2000 On the other hand, benazoline and other I(1) receptor-selective imidazolines decreased forskolin-stimulated cAMP level in the cells expressing I(1)R, in a rauwolscine- and pertussis toxin-insensitive manner. Colforsin 87-96 nischarin Rattus norvegicus 143-148 10880694-1 2000 The effects of a soluble derivative of forskolin and of two membrane-permeable analogs of cAMP, dibutyryl cAMP, and 8-bromo-cAMP, on the ability of a serotonin (5-HT)(1A) receptor agonist to inhibit lordosis behavior were examined. Colforsin 39-48 5-hydroxytryptamine receptor 1A Rattus norvegicus 150-179 10799507-4 2000 In a rat hepatoma Rh7777 cell line that exhibits modest endogenous responses to sphingosine 1-phosphate, this lipid mediator inhibited forskolin-driven rises in cAMP by greater than 90% when the cells were transfected with Edg-8 DNA (IC(50) 0.7 nm). Colforsin 135-144 sphingosine-1-phosphate receptor 5 Rattus norvegicus 223-228 10828079-7 2000 Forskolin, a known activator of adenylate cyclase, and dibutryl-cAMP, a cAMP analog, induced COX-1 and COX-2 mRNA, suggesting that cAMP is a second messenger for COX expression. Colforsin 0-9 mitochondrially encoded cytochrome c oxidase I Homo sapiens 93-98 10828079-7 2000 Forskolin, a known activator of adenylate cyclase, and dibutryl-cAMP, a cAMP analog, induced COX-1 and COX-2 mRNA, suggesting that cAMP is a second messenger for COX expression. Colforsin 0-9 mitochondrially encoded cytochrome c oxidase II Homo sapiens 103-108 10848557-9 2000 Forskolin, an activator of PKA, increases baseline evoked IPSCs as well as the number of sIPSCs, and a tetanic stimulation during this enhancement uncovers a long-term depression of the evoked IPSC. Colforsin 0-9 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 27-30 10849366-9 2000 Furthermore, the expressions of both c-Myc and Mad1 were reduced by forskolin, which also inhibited the anti-mu + TPA driven growth and differentiation of the B lymphocytes. Colforsin 68-77 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-42 10849366-9 2000 Furthermore, the expressions of both c-Myc and Mad1 were reduced by forskolin, which also inhibited the anti-mu + TPA driven growth and differentiation of the B lymphocytes. Colforsin 68-77 MAX dimerization protein 1 Homo sapiens 47-51 10814518-4 2000 CF gene expression was measured by Northern analysis and CFTR function by forskolin-stimulated (125)I efflux. Colforsin 74-83 CF transmembrane conductance regulator Homo sapiens 57-61 10804204-8 2000 The action of VIP is cAMP-mediated because (1) activation of cAMP by forskolin mimics the action; (2) PKA inhibition by H89 reverses the neuropeptide-induced inhibition; and (3) the lipophilic neuropeptide mimic, stearyl-norleucine(17) VIP (SNV), which does not use a cAMP-mediated pathway, fails to duplicate the inhibition. Colforsin 69-78 vasoactive intestinal peptide Rattus norvegicus 14-17 10788462-7 2000 The HUVEC AEA transporter contributes to the termination of a typical type 1 cannabinoid receptor (CB(1)) -mediated action of AEA, i.e. the inhibition of forskolin-stimulated adenylyl cyclase, because NO/ONOO(-) donors and alpha-linolenoyl-vanillyl-amide/N-(4-hydroxyphenyl)-arachidonoylamide were found to attenuate and enhance, respectively, this effect of AEA. Colforsin 154-163 cannabinoid receptor 1 Homo sapiens 62-104 10799319-6 2000 hPRP4 is activated by epidermal growth factor (EGF) or forskolin treatment, but not tetradecanoyl phorbol acetate (TPA) nor ultraviolet (UV) irradiation. Colforsin 55-64 pre-mRNA processing factor 4 Homo sapiens 0-5 10788429-1 2000 In the EAhy926 endothelial cell line, UTP, ATP, and forskolin, but not UDP and epidermal growth factor, inhibited tumor necrosis factor alpha (TNFalpha)- and sorbitol stimulation of the stress-activated protein kinases, JNK, and p38 mitogen-activated protein (MAP) kinase, and MAPKAP kinase-2, the downstream target of p38 MAP kinase. Colforsin 52-61 tumor necrosis factor Homo sapiens 114-141 10788429-1 2000 In the EAhy926 endothelial cell line, UTP, ATP, and forskolin, but not UDP and epidermal growth factor, inhibited tumor necrosis factor alpha (TNFalpha)- and sorbitol stimulation of the stress-activated protein kinases, JNK, and p38 mitogen-activated protein (MAP) kinase, and MAPKAP kinase-2, the downstream target of p38 MAP kinase. Colforsin 52-61 tumor necrosis factor Homo sapiens 143-151 10788429-1 2000 In the EAhy926 endothelial cell line, UTP, ATP, and forskolin, but not UDP and epidermal growth factor, inhibited tumor necrosis factor alpha (TNFalpha)- and sorbitol stimulation of the stress-activated protein kinases, JNK, and p38 mitogen-activated protein (MAP) kinase, and MAPKAP kinase-2, the downstream target of p38 MAP kinase. Colforsin 52-61 mitogen-activated protein kinase 14 Homo sapiens 229-232 10788429-1 2000 In the EAhy926 endothelial cell line, UTP, ATP, and forskolin, but not UDP and epidermal growth factor, inhibited tumor necrosis factor alpha (TNFalpha)- and sorbitol stimulation of the stress-activated protein kinases, JNK, and p38 mitogen-activated protein (MAP) kinase, and MAPKAP kinase-2, the downstream target of p38 MAP kinase. Colforsin 52-61 MAPK activated protein kinase 2 Homo sapiens 277-292 10788429-1 2000 In the EAhy926 endothelial cell line, UTP, ATP, and forskolin, but not UDP and epidermal growth factor, inhibited tumor necrosis factor alpha (TNFalpha)- and sorbitol stimulation of the stress-activated protein kinases, JNK, and p38 mitogen-activated protein (MAP) kinase, and MAPKAP kinase-2, the downstream target of p38 MAP kinase. Colforsin 52-61 mitogen-activated protein kinase 14 Homo sapiens 319-333 10788432-5 2000 The forskolin/3-isobutyl-1-methylxanthine-stimulated whole-cell conductance in hCFTR-mENaC co-injected oocytes was amiloride-insensitive, indicating an inhibition of mENaC following hCFTR activation, and it was blocked by DPC (diphenylamine-2-carboxylic acid) and was DIDS (4, 4"-diisothiocyanatostilbene-2,2"-disulfonic acid)-insensitive. Colforsin 4-13 CF transmembrane conductance regulator Homo sapiens 79-84 10788432-5 2000 The forskolin/3-isobutyl-1-methylxanthine-stimulated whole-cell conductance in hCFTR-mENaC co-injected oocytes was amiloride-insensitive, indicating an inhibition of mENaC following hCFTR activation, and it was blocked by DPC (diphenylamine-2-carboxylic acid) and was DIDS (4, 4"-diisothiocyanatostilbene-2,2"-disulfonic acid)-insensitive. Colforsin 4-13 sodium channel, nonvoltage-gated 1 alpha Mus musculus 85-90 10788432-5 2000 The forskolin/3-isobutyl-1-methylxanthine-stimulated whole-cell conductance in hCFTR-mENaC co-injected oocytes was amiloride-insensitive, indicating an inhibition of mENaC following hCFTR activation, and it was blocked by DPC (diphenylamine-2-carboxylic acid) and was DIDS (4, 4"-diisothiocyanatostilbene-2,2"-disulfonic acid)-insensitive. Colforsin 4-13 sodium channel, nonvoltage-gated 1 alpha Mus musculus 166-171 10769242-6 2000 The smu(-/-) phenotype is phenocopied by treatment of wild-type embryos with forskolin, which inhibits the response of cells to Hedgehog signaling by indirect activation of cAMP-dependent protein kinase (PKA). Colforsin 77-86 smoothened, frizzled class receptor Danio rerio 4-7 10788432-5 2000 The forskolin/3-isobutyl-1-methylxanthine-stimulated whole-cell conductance in hCFTR-mENaC co-injected oocytes was amiloride-insensitive, indicating an inhibition of mENaC following hCFTR activation, and it was blocked by DPC (diphenylamine-2-carboxylic acid) and was DIDS (4, 4"-diisothiocyanatostilbene-2,2"-disulfonic acid)-insensitive. Colforsin 4-13 CF transmembrane conductance regulator Homo sapiens 182-187 10794664-4 2000 The effect of vasopressin can be mimicked by either forskolin (1-5 microM) or 8-bromo-cAMP/dibutyryl-cAMP (8-Br-cAMP/DBcAMP) (200-500 microM). Colforsin 52-61 arginine vasopressin Rattus norvegicus 14-25 10783131-4 2000 V(2)O(5)-induced ERK-1/2 activation was abolished by pretreatment with forskolin or PD98059, indicating a dependence on Raf and mitogen-activated protein (MAP) kinase kinase, respectively. Colforsin 71-80 mitogen activated protein kinase 3 Rattus norvegicus 17-24 10810292-9 2000 Homologous desensitization of the insulin-potentiating activity of GIP was found to affect both GIP-stimulated and forskolin-stimulated insulin release, indicating desensitization of distal steps in the stimulus-exocytosis cascade. Colforsin 115-124 gastric inhibitory polypeptide Mus musculus 67-70 10803591-9 2000 A-CREB, a dominant negative inhibitor of CREB, completely inhibited forskolin induction of the hD2 promoter. Colforsin 68-77 cAMP responsive element binding protein 1 Homo sapiens 2-6 10803591-9 2000 A-CREB, a dominant negative inhibitor of CREB, completely inhibited forskolin induction of the hD2 promoter. Colforsin 68-77 cAMP responsive element binding protein 1 Homo sapiens 41-45 10803591-9 2000 A-CREB, a dominant negative inhibitor of CREB, completely inhibited forskolin induction of the hD2 promoter. Colforsin 68-77 iodothyronine deiodinase 2 Homo sapiens 95-98 10804017-7 2000 Forskolin, a PKA agonist, increased TGF-beta2 but not TGF-beta1 concentrations in supernatants of human osteoblasts. Colforsin 0-9 transforming growth factor beta 2 Homo sapiens 36-45 10800926-2 2000 Using representational difference analysis, we isolated the cDNA for a previously unidentified gene, rTLE3 (rat transducin-like enhancer of split 3), as a sequence induced by depolarization and forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. Colforsin 194-203 TLE family member 3, transcriptional corepressor Rattus norvegicus 101-106 10777769-7 2000 However, incubation of slices with forskolin, an activator of the cAMP-dependent protein kinase (PKA) cascade, did result in increases in active ERK and cAMP response element-binding protein (CREB) phosphorylation in area CA3. Colforsin 35-44 mitogen-activated protein kinase 1 Homo sapiens 145-148 10777769-7 2000 However, incubation of slices with forskolin, an activator of the cAMP-dependent protein kinase (PKA) cascade, did result in increases in active ERK and cAMP response element-binding protein (CREB) phosphorylation in area CA3. Colforsin 35-44 cAMP responsive element binding protein 1 Homo sapiens 153-190 10777769-7 2000 However, incubation of slices with forskolin, an activator of the cAMP-dependent protein kinase (PKA) cascade, did result in increases in active ERK and cAMP response element-binding protein (CREB) phosphorylation in area CA3. Colforsin 35-44 cAMP responsive element binding protein 1 Homo sapiens 192-196 10797531-2 2000 We found that BDNF-promoted neuritogenesis was enhanced by forskolin in RGCs from rats at P2-P21 plated on either poly-L-lysine or collagen. Colforsin 59-68 brain-derived neurotrophic factor Rattus norvegicus 14-18 10797531-4 2000 Laminin blocked the enhancement of BDNF-induced RGCs neuritogenesis by forskolin, in RGCs from either P14 or P21, and induced a tenfold increase of protein kinase C (PKC) activity compared to poly-L-lysine. Colforsin 71-80 brain-derived neurotrophic factor Rattus norvegicus 35-39 10800926-2 2000 Using representational difference analysis, we isolated the cDNA for a previously unidentified gene, rTLE3 (rat transducin-like enhancer of split 3), as a sequence induced by depolarization and forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. Colforsin 194-203 TLE family member 3, transcriptional corepressor Rattus norvegicus 112-147 10777769-7 2000 However, incubation of slices with forskolin, an activator of the cAMP-dependent protein kinase (PKA) cascade, did result in increases in active ERK and cAMP response element-binding protein (CREB) phosphorylation in area CA3. Colforsin 35-44 carbonic anhydrase 3 Homo sapiens 222-225 10777769-8 2000 The forskolin-induced increase in active ERK was inhibited by U0126, whereas the increase in CREB phosphorylation was not, which suggests that in area CA3 the PKA cascade is not coupled to CREB phosphorylation via ERK. Colforsin 4-13 mitogen-activated protein kinase 1 Homo sapiens 41-44 10779390-6 2000 In a mammalian expression system (Chinese hamster ovary-hCB2 cells), HU210 and 2-AG maximally inhibited forskolin-stimulated cAMP synthesis (IC(50) = 1.61 +/- 0.42 nM and 1.30 +/- 0.37 microM, respectively) although anandamide was ineffective. Colforsin 104-113 cannabinoid receptor 2 Homo sapiens 56-60 10777769-8 2000 The forskolin-induced increase in active ERK was inhibited by U0126, whereas the increase in CREB phosphorylation was not, which suggests that in area CA3 the PKA cascade is not coupled to CREB phosphorylation via ERK. Colforsin 4-13 carbonic anhydrase 3 Homo sapiens 151-154 10779323-3 2000 At maximal doses, administration of EGF resulted in a 50% increase in a subunit reporter activity; forskolin administration induced a fivefold activation; the combined actions of EGF and forskolin resulted in synergistic activation (greater than eightfold) of the alpha subunit reporter. Colforsin 187-196 epidermal growth factor Homo sapiens 36-39 10779323-4 2000 Mutagenesis studies revealed that the cyclic AMP response elements (CRE) were required and sufficient to mediate EGF-forskolin-induced synergistic activation. Colforsin 117-126 epidermal growth factor Homo sapiens 113-116 10779323-5 2000 The combined actions of EGF and forskolin resulted in potentiated activation of extracellular signal-regulated kinase (ERK) enzyme activity compared with EGF alone. Colforsin 32-41 mitogen-activated protein kinase 1 Homo sapiens 80-117 10779323-5 2000 The combined actions of EGF and forskolin resulted in potentiated activation of extracellular signal-regulated kinase (ERK) enzyme activity compared with EGF alone. Colforsin 32-41 mitogen-activated protein kinase 1 Homo sapiens 119-122 10779323-5 2000 The combined actions of EGF and forskolin resulted in potentiated activation of extracellular signal-regulated kinase (ERK) enzyme activity compared with EGF alone. Colforsin 32-41 epidermal growth factor Homo sapiens 154-157 10779323-6 2000 Specific blockade of ERK activation was sufficient to block EGF-forskolin-induced synergistic activation of the alpha subunit reporter. Colforsin 64-73 mitogen-activated protein kinase 1 Homo sapiens 21-24 10779323-6 2000 Specific blockade of ERK activation was sufficient to block EGF-forskolin-induced synergistic activation of the alpha subunit reporter. Colforsin 64-73 epidermal growth factor Homo sapiens 60-63 10779394-2 2000 Following gene transfer of AC6, isoproterenol- and forskolin-stimulated increases in cAMP were markedly enhanced, whereas basal levels of cAMP and responses to several other agonists that stimulate cAMP formation, e. g., prostaglandin E(2) (PGE(2)), H(2) agonist, glucagon, and A(2) agonist were not increased. Colforsin 51-60 adenylate cyclase 6 Homo sapiens 27-30 10779323-8 2000 However, overexpression of c-Jun N-terminal kinase (JNK)-interacting protein 1 as a dominant interfering molecule abolished the synergistic effects of EGF and forskolin on the alpha subunit reporter. Colforsin 159-168 mitogen-activated protein kinase 8 interacting protein 1 Homo sapiens 27-78 10779323-11 2000 Thus, synergistic activation of the alpha subunit gene induced by EGF-forskolin requires the ERK and JNK cascades and the recruitment of AP-1 to the CRE binding complex. Colforsin 70-79 epidermal growth factor Homo sapiens 66-69 10779323-11 2000 Thus, synergistic activation of the alpha subunit gene induced by EGF-forskolin requires the ERK and JNK cascades and the recruitment of AP-1 to the CRE binding complex. Colforsin 70-79 mitogen-activated protein kinase 1 Homo sapiens 93-96 10777606-3 2000 Furthermore, forskolin, which increases intracellular cAMP levels, also effectively suppressed TNFalpha+ActD-induced apoptosis. Colforsin 13-22 cathelicidin antimicrobial peptide Homo sapiens 54-58 10779323-11 2000 Thus, synergistic activation of the alpha subunit gene induced by EGF-forskolin requires the ERK and JNK cascades and the recruitment of AP-1 to the CRE binding complex. Colforsin 70-79 mitogen-activated protein kinase 8 Homo sapiens 101-104 10859531-9 2000 Forskolin, an adenylate cyclase activator, promotes hair epithelial cell growth and boosts the growth-promoting effect of procyanidin B-2. Colforsin 0-9 bradykinin receptor, beta 2 Mus musculus 134-137 10785513-3 2000 Single-channel patch-clamp data revealed that 10 micromol/L isoproterenol, forskolin, or dopamine opens BK(Ca) channels in coronary myocytes and that this effect is attenuated by inhibitors of PKG (KT5823; Rp-8-pCPT-cGMPS), but not by inhibiting the cAMP-dependent protein kinase (protein kinase A, PKA). Colforsin 75-84 protein kinase cGMP-dependent 1 Homo sapiens 193-196 10785513-5 2000 Direct biochemical measurement confirmed that dopamine or forskolin stimulates PKG activity in coronary arteries but does not elevate cGMP. Colforsin 58-67 protein kinase cGMP-dependent 1 Homo sapiens 79-82 10777606-3 2000 Furthermore, forskolin, which increases intracellular cAMP levels, also effectively suppressed TNFalpha+ActD-induced apoptosis. Colforsin 13-22 tumor necrosis factor Homo sapiens 95-103 10764409-7 2000 Forskolin, an activator of adenylyl cyclase, and sodium nitroprusside, an NO donor, increased P-CREB and c-fos levels. Colforsin 0-9 cAMP responsive element binding protein 1 Mus musculus 96-100 10764409-7 2000 Forskolin, an activator of adenylyl cyclase, and sodium nitroprusside, an NO donor, increased P-CREB and c-fos levels. Colforsin 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 105-110 10780975-1 2000 Simultaneous measurements of intracellular calcium concentration ([Ca(2+)](i)) and tension were performed to clarify whether the mechanisms which cause the neuropeptide Y (NPY)-elicited contraction and potentiation of noradrenaline contractions, and the NPY inhibition of forskolin responses are linked to a single or different NPY receptor(s) in rat mesenteric small arteries. Colforsin 272-281 neuropeptide Y Rattus norvegicus 156-170 10814831-5 2000 Transfected Puralpha suppressed the CRE enhancer activity stimulated by forskolin (which increases intracellular cAMP), but suppression was not observed when the PUR element was deleted. Colforsin 72-81 purine rich element binding protein A Rattus norvegicus 12-20 10814831-6 2000 The neurite extension induced by forskolin was inhibited by the transfection of Puralpha, but that by NGF was not suppressed. Colforsin 33-42 purine rich element binding protein A Rattus norvegicus 80-88 10814831-7 2000 The c-fos mRNA induced by forskolin, but not by NGF, was also suppressed by Puralpha transfection. Colforsin 26-35 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 4-9 10814831-7 2000 The c-fos mRNA induced by forskolin, but not by NGF, was also suppressed by Puralpha transfection. Colforsin 26-35 purine rich element binding protein A Rattus norvegicus 76-84 10814831-8 2000 These results indicate that Puralpha suppresses the biological activities induced by forskolin, but not by NGF, in PC12 cells and that Puralpha could interfere with a cAMP-CRE signal pathway. Colforsin 85-94 purine rich element binding protein A Rattus norvegicus 28-36 10742293-9 2000 The increase in cytosolic PKA activity was indirect as (i) it was inhibited by the adenylyl cyclase inhibitor SQ22536, (ii) it was mimicked by forskolin and (iii) 17beta-oestradiol did not cause a stimulation of basal PKA activity in either type I or type II commercially available PKA holoenzymes. Colforsin 143-152 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 26-29 10780975-1 2000 Simultaneous measurements of intracellular calcium concentration ([Ca(2+)](i)) and tension were performed to clarify whether the mechanisms which cause the neuropeptide Y (NPY)-elicited contraction and potentiation of noradrenaline contractions, and the NPY inhibition of forskolin responses are linked to a single or different NPY receptor(s) in rat mesenteric small arteries. Colforsin 272-281 neuropeptide Y Rattus norvegicus 172-175 10780975-6 2000 In arteries activated by vasopressin, the adenylyl cyclase activator forskolin (3 microM) induced a maximum relaxation and a return of [Ca(2+)](i) to resting levels. Colforsin 69-78 arginine vasopressin Rattus norvegicus 25-36 10780975-9 2000 BIBP 3226 competitively antagonized the contraction to NPY in forskolin-relaxed arteries with a pA(2) of 7.92+/-0.29. Colforsin 62-71 neuropeptide Y Rattus norvegicus 55-58 10779013-4 2000 Stimulation of cAMP-dependent pathways with forskolin or dibutyryl cAMP decreased ICAM-1 protein expression, whereas it increased NOS-2 protein expression. Colforsin 44-53 cathelicidin antimicrobial peptide Homo sapiens 15-19 10746643-7 2000 A Ca2+ ionophore mimicked the effects of FSK on IP3R mRNA expression, whereas blockade of voltage-dependent Ca2+ channels or chelation of intracellular Ca2+ inhibited the actions of FSK. Colforsin 41-44 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 48-52 10746643-9 2000 In G-treated islets, FSK slowed IP3R-III mRNA degradation. Colforsin 21-24 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 32-36 10792504-4 2000 PMA-induced MCP-3 mRNA and protein production of human endothelial cells were partially inhibited by pretreatment with the adenylate cyclase activator, forskolin, or membrane-permeable cAMP derivative. Colforsin 152-161 C-C motif chemokine ligand 7 Homo sapiens 12-17 10770202-8 2000 Treatment with 8-bromo-cAMP and forskolin also attenuated P2UR mRNA levels. Colforsin 32-41 purinergic receptor P2Y2 Homo sapiens 58-62 10770202-11 2000 These results demonstrate for the first time that the P2UR mRNA is expressed in hGLCs and that P2UR mRNA is regulated by human CG, cAMP, and forskolin. Colforsin 141-150 purinergic receptor P2Y2 Homo sapiens 95-99 10792504-6 2000 Forskolin inhibited the transcription of PMA-induced MCP-3 gene expression. Colforsin 0-9 C-C motif chemokine ligand 7 Homo sapiens 53-58 10779013-4 2000 Stimulation of cAMP-dependent pathways with forskolin or dibutyryl cAMP decreased ICAM-1 protein expression, whereas it increased NOS-2 protein expression. Colforsin 44-53 intercellular adhesion molecule 1 Homo sapiens 82-88 10737590-2 2000 Treatment of NG108-15 cells with TPA (100 nM) for 48 h increased delta-opioid receptor mRNA levels, whereas different concentrations of forskolin induced a transient down-regulation of mRNA 5 h after treatment, followed by increased mRNA levels after 48 h. Reporter gene assays in transiently transfected NG108-15 cells in combination with electrophoretic mobility shift assays indicate that the increase of delta-opioid receptor mRNA after stimulation with TPA is mediated by transcription factor AP-1, which binds 355 bp upstream of the start codon within the gene promoter. Colforsin 136-145 jun proto-oncogene Mus musculus 498-502 10737590-3 2000 The forskolin-induced mRNA increase is mediated neither by a cyclic AMP-response element nor indirectly by AP-1 up-regulation. Colforsin 4-13 jun proto-oncogene Mus musculus 107-111 10737590-4 2000 Reporter gene assays, mutational analysis, and electrophoretic mobility shift assays revealed that delta-opioid receptor gene regulation by forskolin is mediated by transcription factor AP-2, which binds to an element 157 bp upstream of the start codon. Colforsin 140-149 transcription factor AP-2, alpha Mus musculus 186-190 10773741-0 2000 Estradiol attenuates the forskolin-induced increase in hypothalamic tyrosine hydroxylase activity. Colforsin 25-34 tyrosine hydroxylase Rattus norvegicus 68-88 10750024-3 2000 Forskolin-induced activation of cyclic AMP-dependent protein kinase (PKA) enhanced steroidogenesis and this was accompanied by an increased expression of StAR protein. Colforsin 0-9 steroidogenic acute regulatory protein Mus musculus 154-158 10750028-5 2000 Tumour necrosis factor-alpha (TNFalpha), forskolin and a cell-permeable cAMP analogue (dibutyryl cAMP) caused concentration-dependent increases in ET-2 synthesis. Colforsin 41-50 endothelin 2 Homo sapiens 147-151 10750028-6 2000 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone, indicating that adenylate cyclase and TNFalpha induce ET-2 synthesis by separate signalling pathways. Colforsin 15-24 endothelin 2 Homo sapiens 102-106 10750028-6 2000 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone, indicating that adenylate cyclase and TNFalpha induce ET-2 synthesis by separate signalling pathways. Colforsin 15-24 tumor necrosis factor Homo sapiens 181-189 10750028-6 2000 Combination of forskolin or dibutyryl cAMP with TNFalpha produced a significantly greater increase in ET-2 production than these agents alone, indicating that adenylate cyclase and TNFalpha induce ET-2 synthesis by separate signalling pathways. Colforsin 15-24 endothelin 2 Homo sapiens 197-201 10750028-8 2000 PreproET-2 mRNA levels were increased by TNFalpha at 1 h and 2 h, but returned to control levels at 4 h. Treatment with forskolin significantly increased preproET-2 mRNA levels after 1 h and 4 h. ACHN cells expressed ECE-1b and ECE-1c, but not the ECE-1a isoform of this peptidase. Colforsin 120-129 tumor necrosis factor Homo sapiens 41-49 10750028-8 2000 PreproET-2 mRNA levels were increased by TNFalpha at 1 h and 2 h, but returned to control levels at 4 h. Treatment with forskolin significantly increased preproET-2 mRNA levels after 1 h and 4 h. ACHN cells expressed ECE-1b and ECE-1c, but not the ECE-1a isoform of this peptidase. Colforsin 120-129 endothelin converting enzyme 1 Homo sapiens 217-220 10750028-8 2000 PreproET-2 mRNA levels were increased by TNFalpha at 1 h and 2 h, but returned to control levels at 4 h. Treatment with forskolin significantly increased preproET-2 mRNA levels after 1 h and 4 h. ACHN cells expressed ECE-1b and ECE-1c, but not the ECE-1a isoform of this peptidase. Colforsin 120-129 endothelin converting enzyme 1 Homo sapiens 228-231 10750028-8 2000 PreproET-2 mRNA levels were increased by TNFalpha at 1 h and 2 h, but returned to control levels at 4 h. Treatment with forskolin significantly increased preproET-2 mRNA levels after 1 h and 4 h. ACHN cells expressed ECE-1b and ECE-1c, but not the ECE-1a isoform of this peptidase. Colforsin 120-129 endothelin converting enzyme 1 Homo sapiens 228-231 10766452-8 2000 IAPP (10 microM) enhanced the inhibitory effect of somatostatin on insulin secretion induced by L-arginine or forskolin. Colforsin 110-119 islet amyloid polypeptide Rattus norvegicus 0-4 10773741-2 2000 The first experiment examined the ability of forskolin to activate TH in the tuberoinfundibular dopaminergic neurons of adult ovariectomized rats with or without estradiol treatment. Colforsin 45-54 tyrosine hydroxylase Rattus norvegicus 67-69 10773741-3 2000 Estradiol treatment reduced both basal and forskolin-stimulated TH activity in the median eminence. Colforsin 43-52 tyrosine hydroxylase Rattus norvegicus 64-66 10773741-4 2000 The second group of experiments examined the effect of estradiol on the forskolin-induced activation of TH in fetal hypothalamic cells cultures. Colforsin 72-81 tyrosine hydroxylase Rattus norvegicus 104-106 10773741-6 2000 Forskolin treatment for 1 h increased TH activity in a concentration-dependent manner in control and estradiol-treated cells, but estradiol attenuated the stimulatory response to 0.01-10 microM forskolin. Colforsin 0-9 tyrosine hydroxylase Rattus norvegicus 38-40 10773741-7 2000 The suppressive effect of estradiol on cAMP-dependent activation of TH was evident with 1-12 h of forskolin treatment. Colforsin 98-107 tyrosine hydroxylase Rattus norvegicus 68-70 10773741-9 2000 Forskolin treatment for 1 h increased radiolabeled phosphate incorporation into TH protein in control but not estradiol-treated cells, suggesting that estradiol interferes with the ability of the cAMP pathway to phosphorylate TH. Colforsin 0-9 tyrosine hydroxylase Rattus norvegicus 80-82 10773741-9 2000 Forskolin treatment for 1 h increased radiolabeled phosphate incorporation into TH protein in control but not estradiol-treated cells, suggesting that estradiol interferes with the ability of the cAMP pathway to phosphorylate TH. Colforsin 0-9 tyrosine hydroxylase Rattus norvegicus 226-228 10773741-10 2000 Forskolin caused a time-dependent increase in TH mRNA signal levels in control cultures. Colforsin 0-9 tyrosine hydroxylase Rattus norvegicus 46-48 10773741-11 2000 The magnitude of the forskolin-induced increase in TH mRNA levels was less in the estradiol-treated cells after 6 h of forskolin treatment, indicating that estradiol hinders cAMP-regulated TH gene expression. Colforsin 21-30 tyrosine hydroxylase Rattus norvegicus 51-53 10720069-6 2000 Both forskolin and 8-bromo-cAMP, activators of protein kinase A, can increase CRH promoter activity 5-fold in transiently transfected human primary placental cells, in a manner that parallels the increase in endogenous CRH peptide. Colforsin 5-14 corticotropin releasing hormone Homo sapiens 78-81 10739532-11 2000 Stimulatory action of keratinocyte growth factor on human chorionic gonadotropin production in the BeWo cells was markedly enhanced after forskolin-induced differentiation. Colforsin 138-147 fibroblast growth factor 7 Homo sapiens 22-48 10725275-11 2000 Treatment with forskolin (4 h) or dexamethasone (4 h) significantly reduced beta(3a)-AR mRNA levels in BAT and WAT but did not alter levels in ileum. Colforsin 15-24 adaptor-related protein complex 3, beta 1 subunit Mus musculus 76-83 10700725-8 2000 Incubation of the NCI-h295 tumour cell line with 10nmol ACTH and 10micromol forskolin induced an increase in the abundance of StAR and P450scc mRNA, demonstrating gene regulation by the cAMP protein kinase A pathway. Colforsin 76-85 steroidogenic acute regulatory protein Homo sapiens 126-130 10700725-8 2000 Incubation of the NCI-h295 tumour cell line with 10nmol ACTH and 10micromol forskolin induced an increase in the abundance of StAR and P450scc mRNA, demonstrating gene regulation by the cAMP protein kinase A pathway. Colforsin 76-85 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 135-142 10694507-3 2000 Forskolin, IBMX, and dbcAMP reduced [(3)H]arachidonic acid ([(3)H]AA) efflux from prelabelled islets during PLA(2) activation by mellitin or cholecystokinin (CCK-8), while efflux induced by carbachol was unaffected. Colforsin 0-9 phospholipase A2 group IB Rattus norvegicus 108-114 10704620-11 2000 Activation of adenyl cyclase (with forskolin) caused a significant increase in cells expressing ICAM-1. Colforsin 35-44 intercellular adhesion molecule 1 Rattus norvegicus 96-102 10786926-4 2000 The amount of alpha subunit of stimulatory GTP-binding protein (GSalpha) and adenylyl cyclase activity in response to forskolin were not different in the two cell lines. Colforsin 118-127 GNAS complex locus Homo sapiens 64-71 10714824-7 2000 The highest level of expression of Gas6 messenger RNA (mRNA) was observed in the Sertoli cells, and its expression was responsive to the addition of forskolin in vitro. Colforsin 149-158 growth arrest specific 6 Mus musculus 35-39 10714824-10 2000 The forskolin-stimulated Gas6 expression was accompanied by an increase in tyrosine phosphorylation of the Rse receptor in vitro, suggesting that Gas6 may exhibit an autocrine effect in the Sertoli cells through multiple tyrosine kinase receptors. Colforsin 4-13 growth arrest specific 6 Mus musculus 25-29 10714824-10 2000 The forskolin-stimulated Gas6 expression was accompanied by an increase in tyrosine phosphorylation of the Rse receptor in vitro, suggesting that Gas6 may exhibit an autocrine effect in the Sertoli cells through multiple tyrosine kinase receptors. Colforsin 4-13 growth arrest specific 6 Mus musculus 146-150 10720069-6 2000 Both forskolin and 8-bromo-cAMP, activators of protein kinase A, can increase CRH promoter activity 5-fold in transiently transfected human primary placental cells, in a manner that parallels the increase in endogenous CRH peptide. Colforsin 5-14 corticotropin releasing hormone Homo sapiens 219-222 10720069-7 2000 Maximal stimulation of CRH promoter activity occurs at 500 micromol/L 8-bromo-cAMP and 10 micromol/L forskolin. Colforsin 101-110 corticotropin releasing hormone Homo sapiens 23-26 10676852-6 2000 IFN alpha could significantly inhibit the production of the cAMP stimulated by forskolin in SK-N-SH cells expressing the mu-opioid receptor, not in NG108-15 cells expressing the delta-opioid receptor uniformly. Colforsin 79-88 interferon alpha 1 Homo sapiens 0-9 10669727-6 2000 This approach identified Galpha(i)2 and Galpha(i)3 as mediators of the D2S receptor-mediated inhibition of forskolin-stimulated adenylyl cyclase activity; Galpha(i)2-mediated D2S-induced stimulation of p42 and p44 mitogen-activated kinase (MAPK) and DNA synthesis, whereas Galpha(i)3 was required for formation of transformed foci. Colforsin 107-116 guanine nucleotide binding protein (G protein), alpha inhibiting 3 Mus musculus 25-50 10676857-1 2000 The stereoselectivity of the serotonin1A (5-HT1A) receptor compound 8-hydroxy-2(di-N-propylamino)tetralin (8-OH-DPAT) on forskolin-stimulated adenylyl cyclase activity was investigated in membranes from human 5-HT pre-synaptic (raphe nuclei) and post-synaptic (hippocampus and prefrontal cortex) regions of autopsy brains. Colforsin 121-130 5-hydroxytryptamine receptor 1A Homo sapiens 29-58 10669727-6 2000 This approach identified Galpha(i)2 and Galpha(i)3 as mediators of the D2S receptor-mediated inhibition of forskolin-stimulated adenylyl cyclase activity; Galpha(i)2-mediated D2S-induced stimulation of p42 and p44 mitogen-activated kinase (MAPK) and DNA synthesis, whereas Galpha(i)3 was required for formation of transformed foci. Colforsin 107-116 guanine nucleotide binding protein (G protein), alpha inhibiting 2 Mus musculus 25-35 10669727-6 2000 This approach identified Galpha(i)2 and Galpha(i)3 as mediators of the D2S receptor-mediated inhibition of forskolin-stimulated adenylyl cyclase activity; Galpha(i)2-mediated D2S-induced stimulation of p42 and p44 mitogen-activated kinase (MAPK) and DNA synthesis, whereas Galpha(i)3 was required for formation of transformed foci. Colforsin 107-116 cyclin-dependent kinase 20 Mus musculus 202-205 10657611-6 2000 By contrast, cAMP agonists (dibutyryl-cAMP and forskolin) induced apoptosis via TNF-alpha, as evidenced by 1) the ability of anti-TNF-alpha mAbs to abrogate cAMP analogue-induced DP apoptosis in a dose-dependent manner; and 2) increased resistance of DP thymocytes from TNF-alpha-/- and TNFR I-/-II-/- animals to cAMP agonist-mediated apoptosis. Colforsin 47-56 tumor necrosis factor Mus musculus 80-89 10669727-6 2000 This approach identified Galpha(i)2 and Galpha(i)3 as mediators of the D2S receptor-mediated inhibition of forskolin-stimulated adenylyl cyclase activity; Galpha(i)2-mediated D2S-induced stimulation of p42 and p44 mitogen-activated kinase (MAPK) and DNA synthesis, whereas Galpha(i)3 was required for formation of transformed foci. Colforsin 107-116 mitogen-activated protein kinase 3 Mus musculus 210-213 10669727-6 2000 This approach identified Galpha(i)2 and Galpha(i)3 as mediators of the D2S receptor-mediated inhibition of forskolin-stimulated adenylyl cyclase activity; Galpha(i)2-mediated D2S-induced stimulation of p42 and p44 mitogen-activated kinase (MAPK) and DNA synthesis, whereas Galpha(i)3 was required for formation of transformed foci. Colforsin 107-116 mitogen-activated protein kinase 3 Mus musculus 240-244 10669727-6 2000 This approach identified Galpha(i)2 and Galpha(i)3 as mediators of the D2S receptor-mediated inhibition of forskolin-stimulated adenylyl cyclase activity; Galpha(i)2-mediated D2S-induced stimulation of p42 and p44 mitogen-activated kinase (MAPK) and DNA synthesis, whereas Galpha(i)3 was required for formation of transformed foci. Colforsin 107-116 guanine nucleotide binding protein (G protein), alpha inhibiting 3 Mus musculus 40-50 10707961-11 2000 However, the phosphorylation of S727 in STAT1 was induced by IFN-gamma, TSH, and forskolin. Colforsin 81-90 signal transducer and activator of transcription 1 Rattus norvegicus 40-45 10707962-8 2000 In B16 melanoma cells, the high basal expression of TFE3 is down-regulated by forskolin and by alphaMSH. Colforsin 78-87 transcription factor E3 Mus musculus 52-56 10698678-4 2000 In addition to the classical bile acids deoxycholate (DCA) and chenodeoxycholate (CDCA), FXR was shown to be transcriptionally active in the presence of the androgen catabolites 5alpha-androstan-3alpha-ol-17-one (androsterone) and 5beta-androstan-3alpha-ol-17-one (etiocholanolone), as well as the sterol bronchodilatory drug forskolin. Colforsin 326-335 nuclear receptor subfamily 1 group H member 4 Homo sapiens 89-92 10698678-7 2000 By far, the most efficacious activator of FXR was forskolin. Colforsin 50-59 nuclear receptor subfamily 1 group H member 4 Homo sapiens 42-45 10698678-9 2000 These data would suggest that forskolin acts as a ligand for FXR rather than as a secondary activator of FXR and could have important implications with respect to its potential toxicity and pharmacological use. Colforsin 30-39 nuclear receptor subfamily 1 group H member 4 Homo sapiens 61-64 10698678-9 2000 These data would suggest that forskolin acts as a ligand for FXR rather than as a secondary activator of FXR and could have important implications with respect to its potential toxicity and pharmacological use. Colforsin 30-39 nuclear receptor subfamily 1 group H member 4 Homo sapiens 105-108 10692489-6 2000 Alanine replacement of glutamine 286, located at the C terminus of TM VI, yields a mutant receptor that binds nociceptin with nearly the same affinity as does the wild-type receptor (K(d) values of 0.13 and 0.22 nM, respectively) but, unlike the latter, is unable to mediate nociceptin inhibition of forskolin-induced cAMP synthesis in recombinant Chinese hamster ovary cells (ED(50) > 10,000 nM compared with 0.8 nM at the wild-type receptor). Colforsin 300-309 prepronociceptin Cricetulus griseus 110-120 10688975-6 2000 Forskolin, a direct activator of adenylyl cyclase also stimulated ERK and P38 activities in these cells suggesting the invovement of cAMP in this process. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 66-69 10688975-6 2000 Forskolin, a direct activator of adenylyl cyclase also stimulated ERK and P38 activities in these cells suggesting the invovement of cAMP in this process. Colforsin 0-9 mitogen-activated protein kinase 14 Homo sapiens 74-77 10657611-6 2000 By contrast, cAMP agonists (dibutyryl-cAMP and forskolin) induced apoptosis via TNF-alpha, as evidenced by 1) the ability of anti-TNF-alpha mAbs to abrogate cAMP analogue-induced DP apoptosis in a dose-dependent manner; and 2) increased resistance of DP thymocytes from TNF-alpha-/- and TNFR I-/-II-/- animals to cAMP agonist-mediated apoptosis. Colforsin 47-56 tumor necrosis factor Mus musculus 130-139 10657611-6 2000 By contrast, cAMP agonists (dibutyryl-cAMP and forskolin) induced apoptosis via TNF-alpha, as evidenced by 1) the ability of anti-TNF-alpha mAbs to abrogate cAMP analogue-induced DP apoptosis in a dose-dependent manner; and 2) increased resistance of DP thymocytes from TNF-alpha-/- and TNFR I-/-II-/- animals to cAMP agonist-mediated apoptosis. Colforsin 47-56 tumor necrosis factor Mus musculus 130-139 10657611-6 2000 By contrast, cAMP agonists (dibutyryl-cAMP and forskolin) induced apoptosis via TNF-alpha, as evidenced by 1) the ability of anti-TNF-alpha mAbs to abrogate cAMP analogue-induced DP apoptosis in a dose-dependent manner; and 2) increased resistance of DP thymocytes from TNF-alpha-/- and TNFR I-/-II-/- animals to cAMP agonist-mediated apoptosis. Colforsin 47-56 tumor necrosis factor receptor superfamily, member 1a Mus musculus 287-293 11263257-7 2000 Importantly, GABABR2 receptors can form a heteromeric assembly with GABABR1 proteins to operate as a heterodimer that displays robust coupling to inward-rectifying K+ channels, as well as inhibition of forskolin-stimulated adenylate cyclase activity. Colforsin 202-211 gamma-aminobutyric acid type B receptor subunit 2 Homo sapiens 13-20 10710282-7 2000 Examination of BIBP3226 antagonism of NPY inhibition of forskolin stimulated cyclic AMP accumulation reveals that it is a competitive antagonist with a K(B) similar to the IC50 for [125I]BIBP3226 binding. Colforsin 56-65 neuropeptide Y Bos taurus 38-41 11263257-7 2000 Importantly, GABABR2 receptors can form a heteromeric assembly with GABABR1 proteins to operate as a heterodimer that displays robust coupling to inward-rectifying K+ channels, as well as inhibition of forskolin-stimulated adenylate cyclase activity. Colforsin 202-211 gamma-aminobutyric acid type B receptor subunit 1 Homo sapiens 68-75 10737676-1 2000 Aiming to develop a functional assay for the human NPY Y5 receptor based on adenylyl cyclase activity, HEC-1B cells, in which cAMP synthesis can be efficiently stimulated with forskolin, were selected for the transfection with the pcDNA3-Y5-FLAG and the pcDEF3-Y5 vectors. Colforsin 176-185 neuropeptide Y receptor Y5 Homo sapiens 51-66 10653816-6 2000 In cells expressing GFP-AQP2, fluorescence recovered to >98% with D of 5.7 and 9.0 x 10(-11) cm(2)/s at 23 degrees C and 37 degrees C. In contrast to results for GFP-AQP1, the cAMP agonist forskolin slowed GFP-AQP2 mobility by up to tenfold. Colforsin 192-201 aquaporin 2 Sus scrofa 24-28 10811295-15 2000 In non-adrenal cells, the forskolin-responsiveness was observed only when SF-1-expressing plasmid was cotransfected. Colforsin 26-35 splicing factor 1 Homo sapiens 74-78 10650934-10 2000 In contrast, increasing intracellular cAMP with forskolin resulted in abrogation of IGF-I-induced JNK activity. Colforsin 48-57 insulin like growth factor 1 Homo sapiens 84-89 10650934-10 2000 In contrast, increasing intracellular cAMP with forskolin resulted in abrogation of IGF-I-induced JNK activity. Colforsin 48-57 mitogen-activated protein kinase 8 Homo sapiens 98-101 10855687-5 2000 Using antisense-transfected ROS cells, PTH/PTHrP receptor mRNA expression and 125I-[Tyr36] PTHrP (1-36) binding were downregulated by treatment for 24 h with exogenous PTHrP (1-36), forskolin, or dibutyryl cAMP. Colforsin 182-191 parathyroid hormone Rattus norvegicus 39-42 10855687-5 2000 Using antisense-transfected ROS cells, PTH/PTHrP receptor mRNA expression and 125I-[Tyr36] PTHrP (1-36) binding were downregulated by treatment for 24 h with exogenous PTHrP (1-36), forskolin, or dibutyryl cAMP. Colforsin 182-191 parathyroid hormone-like hormone Rattus norvegicus 43-48 10651985-6 2000 Treatment of melanocyte cultures with yohimbine blocks the increase in tyrosinase activity by either 3-isobutyl-1-methylxanthine, dibutyryl cAMP, or forskolin. Colforsin 149-158 tyrosinase Homo sapiens 71-81 10672003-4 2000 Our results showed a negative role of the cAMP-dependent pathway, as treatment with cAMP-dependent protein kinase (PKA) activators (10 microM dibutyryl-cAMP and 50 microM forskolin) dramatically inhibited PB-induced Cyp2b9/10 mRNA accumulation, whereas PKA inhibitor potentiated the PB responsiveness of this gene. Colforsin 171-180 cytochrome P450, family 2, subfamily b, polypeptide 9 Mus musculus 216-222 10649505-4 2000 Functional analysis using forskolin-stimulated efflux of (125)I in HEK cells transfected with an ABCC7 construct harboring the L1093P mutation confirmed that cAMP-mediated anion efflux was abnormal, but some function was preserved. Colforsin 26-35 CF transmembrane conductance regulator Homo sapiens 97-102 10646500-7 2000 The level of PACAP mRNA peaked 3 h after stimulation and gradually returned to basal levels by 48 h. PC12 cells are known to express predominantly the hop isoform of the PAC1 receptor, which positively couples to both adenylate cyclase and phospholipase C. To determine the role of the cyclic AMP and protein kinase C pathways in PACAP gene expression, the effects of forskolin and phorbol 12-myristate 13-acetate (PMA) were then examined. Colforsin 368-377 adenylate cyclase activating polypeptide 1 Rattus norvegicus 13-18 10646500-8 2000 PMA did not alter PACAP mRNA levels but enhanced forskolin-induced PACAP mRNA expression. Colforsin 49-58 adenylate cyclase activating polypeptide 1 Rattus norvegicus 67-72 10686086-8 2000 A significant increase in photoreceptor survival was seen with forskolin added to CNTF, but not to BDNF, FGF2, or GDNF. Colforsin 63-72 ciliary neurotrophic factor Mus musculus 82-86 10766260-4 2000 These effects of forskolin were associated with overexpression of type-3 adenylyl cyclase (AC) mRNA due to the presence of two functional point mutations in the promoter region of AC3 gene in GK rat. Colforsin 17-26 adenylate cyclase 3 Rattus norvegicus 180-183 10746226-3 2000 It is postulated that a similar type of mechanism may be operative in C. albicans and protein phosphorylation inhibitors: forskolin (stimulates cyclic adenosine monophosphate production), okadaic acid (phosphatase inhibitor) and D-erythro-sphingosine (retinoblastoma protein phosphorylation inhibitor) have been used to further strengthen this hypothesis. Colforsin 122-131 RB transcriptional corepressor 1 Homo sapiens 252-266 10713964-12 2000 The forskolin- and isoprenaline-induced increases in IKr were inhibited by staurosporine and by the selective protein kinase C (PKC) inhibitor bisindolymaleimide I. Colforsin 4-13 Prkca Cavia porcellus 110-126 10713964-12 2000 The forskolin- and isoprenaline-induced increases in IKr were inhibited by staurosporine and by the selective protein kinase C (PKC) inhibitor bisindolymaleimide I. Colforsin 4-13 Prkca Cavia porcellus 128-131 10664502-9 2000 This impaired vasorelaxation was associated with increases in the phosphorylation of HSP27 and decreases in forskolin-induced phosphorylation of HSP20. Colforsin 108-117 heat shock protein beta-6 Bos taurus 145-150 10650183-4 2000 Nociceptin/orphanin FQ-induced suppression of cyclic AMP accumulation elicited by forskolin was completely inhibited by J-113397 with an IC(50) value of 26 nM. Colforsin 82-91 prepronociceptin Cricetulus griseus 0-10 10627461-8 2000 Forskolin treatment of Chinese hamster ovary cells expressing wild-type GpIbalpha/beta/IX resulted in the phosphorylation of GpIbbeta associated with enhanced binding of GpIbbeta to GST-14-3-3zeta fusion protein and increased 14-3-3zeta coimmunoprecipitated with GpIbalpha. Colforsin 0-9 glycoprotein Ib platelet subunit alpha Homo sapiens 72-81 10627461-8 2000 Forskolin treatment of Chinese hamster ovary cells expressing wild-type GpIbalpha/beta/IX resulted in the phosphorylation of GpIbbeta associated with enhanced binding of GpIbbeta to GST-14-3-3zeta fusion protein and increased 14-3-3zeta coimmunoprecipitated with GpIbalpha. Colforsin 0-9 glycoprotein Ib platelet subunit beta Homo sapiens 125-133 10627461-8 2000 Forskolin treatment of Chinese hamster ovary cells expressing wild-type GpIbalpha/beta/IX resulted in the phosphorylation of GpIbbeta associated with enhanced binding of GpIbbeta to GST-14-3-3zeta fusion protein and increased 14-3-3zeta coimmunoprecipitated with GpIbalpha. Colforsin 0-9 glycoprotein Ib platelet subunit beta Homo sapiens 170-178 10627461-8 2000 Forskolin treatment of Chinese hamster ovary cells expressing wild-type GpIbalpha/beta/IX resulted in the phosphorylation of GpIbbeta associated with enhanced binding of GpIbbeta to GST-14-3-3zeta fusion protein and increased 14-3-3zeta coimmunoprecipitated with GpIbalpha. Colforsin 0-9 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Homo sapiens 186-196 10627461-8 2000 Forskolin treatment of Chinese hamster ovary cells expressing wild-type GpIbalpha/beta/IX resulted in the phosphorylation of GpIbbeta associated with enhanced binding of GpIbbeta to GST-14-3-3zeta fusion protein and increased 14-3-3zeta coimmunoprecipitated with GpIbalpha. Colforsin 0-9 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Homo sapiens 226-236 10627461-8 2000 Forskolin treatment of Chinese hamster ovary cells expressing wild-type GpIbalpha/beta/IX resulted in the phosphorylation of GpIbbeta associated with enhanced binding of GpIbbeta to GST-14-3-3zeta fusion protein and increased 14-3-3zeta coimmunoprecipitated with GpIbalpha. Colforsin 0-9 glycoprotein Ib platelet subunit alpha Homo sapiens 263-272 10648887-4 2000 In addition, ERK activation was also observed following treatment with phorbol dibutyrate (PdBu) and forskolin, activators of protein kinase C (PKC) and protein kinase A (PKA), respectively. Colforsin 101-110 Eph receptor B1 Rattus norvegicus 13-16 10625638-6 2000 We have found that forskolin, cAMP, and PTH, as well as insulin-like growth factor I (IGF-I) and basic fibroblast growth factor, all were effective in activating the osteocalcin promoter. Colforsin 19-28 bone gamma-carboxyglutamate protein Homo sapiens 166-177 10617655-2 2000 In Xenopus oocytes, during two-electrode voltage-clamp, forskolin plus isobutylmethylxanthine induced a Ca(2+)-dependent increase in hIK1 activity. Colforsin 56-65 potassium calcium-activated channel subfamily N member 4 Homo sapiens 133-137 10644591-1 2000 Incubation of spontaneously beating ventricular cardiomyocytes from neonatal rats with prostaglandin E(2) (0.1 microM) or forskolin (0.1 microM) simultaneously increased the rate of cellular contraction and atrial natriuretic peptide (ANP) secretion. Colforsin 122-131 natriuretic peptide A Rattus norvegicus 207-233 10644591-1 2000 Incubation of spontaneously beating ventricular cardiomyocytes from neonatal rats with prostaglandin E(2) (0.1 microM) or forskolin (0.1 microM) simultaneously increased the rate of cellular contraction and atrial natriuretic peptide (ANP) secretion. Colforsin 122-131 natriuretic peptide A Rattus norvegicus 235-238 10629088-8 2000 Down-regulation of Pgp by H(2)O(2) was abolished when either forskolin, 8-Br-cAMP or IBMX, which raise intracellular cAMP levels, was co-administered, indicating that Pgp expression is regulated by protein kinase A (PKA). Colforsin 61-70 ATP binding cassette subfamily B member 1 Homo sapiens 19-22 10629088-8 2000 Down-regulation of Pgp by H(2)O(2) was abolished when either forskolin, 8-Br-cAMP or IBMX, which raise intracellular cAMP levels, was co-administered, indicating that Pgp expression is regulated by protein kinase A (PKA). Colforsin 61-70 ATP binding cassette subfamily B member 1 Homo sapiens 167-170 10620710-0 2000 Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat-1 fibroblasts. Colforsin 0-9 period circadian regulator 1 Rattus norvegicus 47-52 10620710-0 2000 Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat-1 fibroblasts. Colforsin 0-9 period circadian regulator 2 Rattus norvegicus 54-59 10620710-0 2000 Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat-1 fibroblasts. Colforsin 0-9 D-box binding PAR bZIP transcription factor Homo sapiens 64-67 10620710-3 2000 In the present study, we incubated rat-1 cells with forskolin and successfully induced the rhythmic expression of Per1, Per2 and dbp. Colforsin 52-61 period circadian regulator 2 Rattus norvegicus 120-124 10620710-3 2000 In the present study, we incubated rat-1 cells with forskolin and successfully induced the rhythmic expression of Per1, Per2 and dbp. Colforsin 52-61 D-box binding PAR bZIP transcription factor Rattus norvegicus 129-132 10849656-11 2000 Thus, the mechanism by which hypoxia regulates CREB is distinct, and more complex, than that induced by forskolin, depolarization, or nerve growth factor. Colforsin 104-113 cAMP responsive element binding protein 1 Rattus norvegicus 47-51 10644591-3 2000 By contrast, a higher regimen of forskolin (10 microM) promoted a 20- to 30-fold increase in basal cAMP production, which was accompanied by the abolition of contractile activity and ANP release. Colforsin 33-42 natriuretic peptide A Rattus norvegicus 183-186 11193856-4 2000 Analysis of PACAP promoter activity in PC12 cells suggests that forskolin responsiveness of the gene is dependent on elements located between -77 and -413 bp from the transcription start site. Colforsin 64-73 adenylate cyclase activating polypeptide 1 Rattus norvegicus 12-17 10648887-4 2000 In addition, ERK activation was also observed following treatment with phorbol dibutyrate (PdBu) and forskolin, activators of protein kinase C (PKC) and protein kinase A (PKA), respectively. Colforsin 101-110 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 153-169 10648887-4 2000 In addition, ERK activation was also observed following treatment with phorbol dibutyrate (PdBu) and forskolin, activators of protein kinase C (PKC) and protein kinase A (PKA), respectively. Colforsin 101-110 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 171-174 10648887-7 2000 Ras activation by cAMP was unique for neurons, since in PC12 cells forskolin caused activation of ERK but did not increase Ras-GTP level. Colforsin 67-76 Eph receptor B1 Rattus norvegicus 98-101 11235988-4 2000 When HT-1080 cells were pretreated with cAMP elevating reagents, forskolin and dibutyryl cAMP for 4 h instead of heat shock and then maintained in a fresh medium, the production and gene expression of MT1-MMP were similarly suppressed. Colforsin 65-74 matrix metallopeptidase 14 Homo sapiens 201-208 11213468-2 2000 Forskolin, dibutyryl cAMP, and a phosphodiesterase inhibitor, 3-isobutyl-1-methyl xanthine, resulted in an elevated production of nitrite and nitrate, NOS II activities, NOS II mRNA accumulation, and the protein level in RAW264.7 cells stimulated with LPS or IFN-gamma. Colforsin 0-9 nitric oxide synthase 2, inducible Mus musculus 151-157 11213468-2 2000 Forskolin, dibutyryl cAMP, and a phosphodiesterase inhibitor, 3-isobutyl-1-methyl xanthine, resulted in an elevated production of nitrite and nitrate, NOS II activities, NOS II mRNA accumulation, and the protein level in RAW264.7 cells stimulated with LPS or IFN-gamma. Colforsin 0-9 nitric oxide synthase 2, inducible Mus musculus 170-176 11213468-2 2000 Forskolin, dibutyryl cAMP, and a phosphodiesterase inhibitor, 3-isobutyl-1-methyl xanthine, resulted in an elevated production of nitrite and nitrate, NOS II activities, NOS II mRNA accumulation, and the protein level in RAW264.7 cells stimulated with LPS or IFN-gamma. Colforsin 0-9 interferon gamma Mus musculus 259-268 10769627-4 2000 Exposure to the c-AMP dependent protein kinase (PKA) activator, forskolin, did not decrease the phosphorylation of p53 protein. Colforsin 64-73 cathelicidin antimicrobial peptide Mus musculus 16-21 10769627-4 2000 Exposure to the c-AMP dependent protein kinase (PKA) activator, forskolin, did not decrease the phosphorylation of p53 protein. Colforsin 64-73 mitogen-activated protein kinase kinase kinase 14 Mus musculus 32-46 10769627-4 2000 Exposure to the c-AMP dependent protein kinase (PKA) activator, forskolin, did not decrease the phosphorylation of p53 protein. Colforsin 64-73 mitogen-activated protein kinase kinase kinase 14 Mus musculus 48-51 10694248-11 2000 The responses to the NO donor, SIN-1 (10 nM - 100 microM), and to 8-Br-cyclic GMP (10 nM - 100 microM) were markedly impaired in strips from cGKI-deficient mice, whereas the responses to VIP (0.1 nM - 1 microM) and forskolin (0.1 nM - 1 microM) were similar to those in wild type mice. Colforsin 215-224 protein kinase cGMP-dependent 1 Homo sapiens 141-145 11235988-5 2000 The MT1-MMP-mediated activation of proMMP-2 was also inhibited in the forskolin- and dibutyryl cAMP-treated HT-1080 cells. Colforsin 70-79 matrix metallopeptidase 14 Homo sapiens 4-11 10670453-7 2000 Western blot analysis of total protein extracts revealed the appearance of a higher molecular weight connexin43 protein band after treatment of SVG cells with forskolin or forskolin + 3-isobutyl-1-methylxanthine, that was not observed in vehicle-treated controls. Colforsin 159-168 gap junction protein alpha 1 Homo sapiens 101-111 10741304-0 2000 Forskolin and phorbol ester have opposite effects on the expression of mucin-associated sialyl-Lewis(a) in pancreatic cancer cells. Colforsin 0-9 LOC100508689 Homo sapiens 71-76 10741304-5 2000 Forskolin also increased the cellular content of antigen and MUC1 mRNA. Colforsin 0-9 mucin 1, cell surface associated Homo sapiens 61-65 10614620-9 2000 In vitro, forskolin and dibutyryl cAMP similarly elevated RGS2 mRNA. Colforsin 10-19 regulator of G protein signaling 2 Homo sapiens 58-62 10642304-5 2000 The protein of p53 was potentiated by cilostazol as well as forskolin and 8-bromo-cAMP, whereas PDGF decreased p53 expression. Colforsin 60-69 tumor protein p53 Homo sapiens 15-18 10670453-7 2000 Western blot analysis of total protein extracts revealed the appearance of a higher molecular weight connexin43 protein band after treatment of SVG cells with forskolin or forskolin + 3-isobutyl-1-methylxanthine, that was not observed in vehicle-treated controls. Colforsin 172-181 gap junction protein alpha 1 Homo sapiens 101-111 10670453-10 2000 In addition, treatment of the SVG cells with the forskolin or forskolin + 3-isobutyl-l-methylxanthine stimulated outgrowth of neurite-like processes from the cell body which immunostained positive for the connexin43 protein as well as protein markers for neurons and oligodendrocytes. Colforsin 49-58 gap junction protein alpha 1 Homo sapiens 205-215 10670453-10 2000 In addition, treatment of the SVG cells with the forskolin or forskolin + 3-isobutyl-l-methylxanthine stimulated outgrowth of neurite-like processes from the cell body which immunostained positive for the connexin43 protein as well as protein markers for neurons and oligodendrocytes. Colforsin 62-71 gap junction protein alpha 1 Homo sapiens 205-215 10585888-4 1999 The adenylyl cyclase activator, forskolin, decreased phosphorylation of this P20 isoform and increased phosphorylation of another two P20 isoforms, with pI values of 5.9 and 5.6. Colforsin 32-41 heat shock protein family B (small) member 6 Rattus norvegicus 77-80 10707900-0 1999 Promotion of forskolin-induced long-term potentiation of synaptic transmission by caffeine in area CA1 of the rat hippocampus. Colforsin 13-22 carbonic anhydrase 1 Rattus norvegicus 99-102 10585876-11 1999 We here demonstrated that there was a dramatic rise of Id2 and Id3 mRNA levels when 3T3-L1 adipocytes or isolated rat fat cells were exposed to lipolytic and anti-lipogenic agents, forskolin and isoproterenol. Colforsin 181-190 inhibitor of DNA binding 2 Mus musculus 55-58 10606728-3 1999 Here, we show that, in MCF-7 cells: (i) forskolin and the mitogen-activated protein kinase (MAPK) kinase inhibitor PD098059 prevent, and the protein kinase A inhibitor RpcAMPs mimics, the inhibitory effects of ANA on cell proliferation and PRLr/trk expression and (ii) ANA inhibits forskolin-induced cAMP formation and stimulates Raf-1 translocation and MAPK activity, in a fashion sensitive to the selective CB(1) antagonist SR141716A. Colforsin 40-49 prolactin receptor Homo sapiens 240-244 10606728-3 1999 Here, we show that, in MCF-7 cells: (i) forskolin and the mitogen-activated protein kinase (MAPK) kinase inhibitor PD098059 prevent, and the protein kinase A inhibitor RpcAMPs mimics, the inhibitory effects of ANA on cell proliferation and PRLr/trk expression and (ii) ANA inhibits forskolin-induced cAMP formation and stimulates Raf-1 translocation and MAPK activity, in a fashion sensitive to the selective CB(1) antagonist SR141716A. Colforsin 40-49 neurotrophic receptor tyrosine kinase 1 Homo sapiens 245-248 10606728-3 1999 Here, we show that, in MCF-7 cells: (i) forskolin and the mitogen-activated protein kinase (MAPK) kinase inhibitor PD098059 prevent, and the protein kinase A inhibitor RpcAMPs mimics, the inhibitory effects of ANA on cell proliferation and PRLr/trk expression and (ii) ANA inhibits forskolin-induced cAMP formation and stimulates Raf-1 translocation and MAPK activity, in a fashion sensitive to the selective CB(1) antagonist SR141716A. Colforsin 40-49 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 330-335 10606728-5 1999 Forskolin inhibited MAPK and ANA-induced Raf-1 translocation. Colforsin 0-9 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 41-46 10585876-11 1999 We here demonstrated that there was a dramatic rise of Id2 and Id3 mRNA levels when 3T3-L1 adipocytes or isolated rat fat cells were exposed to lipolytic and anti-lipogenic agents, forskolin and isoproterenol. Colforsin 181-190 inhibitor of DNA binding 3 Mus musculus 63-66 10585888-4 1999 The adenylyl cyclase activator, forskolin, decreased phosphorylation of this P20 isoform and increased phosphorylation of another two P20 isoforms, with pI values of 5.9 and 5.6. Colforsin 32-41 heat shock protein family B (small) member 6 Rattus norvegicus 134-137 10565837-1 1999 Cannabinol (CBN), an immunosuppressive cannabinoid and ligand for the peripheral cannabinoid receptor CB2, inhibits the cAMP signaling cascade in forskolin-stimulated thymocytes. Colforsin 146-155 cannabinoid receptor 2 Homo sapiens 102-105 10594671-5 1999 The D1 dopamine agonist SKF-38393 (250 microM), forskolin (5 microM) and 8Br-cAMP (2 mM), known to activate the cAMP/PKA-dependent signalling pathway, all enhanced the mEPSC frequency. Colforsin 48-57 cathelicidin antimicrobial peptide Rattus norvegicus 112-116 10594671-5 1999 The D1 dopamine agonist SKF-38393 (250 microM), forskolin (5 microM) and 8Br-cAMP (2 mM), known to activate the cAMP/PKA-dependent signalling pathway, all enhanced the mEPSC frequency. Colforsin 48-57 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 117-120 10588815-3 1999 In this study, we examined direct effects of LH, the proinflammatory cytokine, interleukin-1beta (IL-1beta), and pharmacological activators of protein kinase A (PKA) (forskolin and dibutyryl (db) cAMP) and PKC (LH-releasing hormone and phorbol 12-myristate 13-acetate (PMA)) signalling on the expression of 11betaHSD1 mRNA in vitro. Colforsin 167-176 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 143-159 10588815-3 1999 In this study, we examined direct effects of LH, the proinflammatory cytokine, interleukin-1beta (IL-1beta), and pharmacological activators of protein kinase A (PKA) (forskolin and dibutyryl (db) cAMP) and PKC (LH-releasing hormone and phorbol 12-myristate 13-acetate (PMA)) signalling on the expression of 11betaHSD1 mRNA in vitro. Colforsin 167-176 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 161-164 10582593-7 1999 Furthermore, in cortical astrocytes, the simultaneous treatment of hSDF1alpha with the HIV-1 capside glycoprotein gp120 inhibits the cyclic AMP formation induced by forskolin treatment. Colforsin 165-174 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 114-119 10595920-6 1999 Treatment with forskolin but not phorbol 12-myristate 13-acetate (PMA) also inhibited TGF-beta1-induced apoptosis. Colforsin 15-24 transforming growth factor beta 1 Homo sapiens 86-95 10595920-8 1999 Immunocytochemical analysis of the cell cycle cyclin-dependent kinase inhibitor p27 showed that treatment with TGF-beta1, forskolin, PMA, and PACAP increased p27 expression in cultured HP75 cells. Colforsin 122-131 interferon alpha inducible protein 27 Homo sapiens 80-83 10595920-8 1999 Immunocytochemical analysis of the cell cycle cyclin-dependent kinase inhibitor p27 showed that treatment with TGF-beta1, forskolin, PMA, and PACAP increased p27 expression in cultured HP75 cells. Colforsin 122-131 interferon alpha inducible protein 27 Homo sapiens 158-161 10588926-6 1999 After pre-contraction of the tissue with U46619, followed by relaxation with forskolin, the responses to both UK14304 and NPY were enhanced. Colforsin 77-86 neuropeptide Y Homo sapiens 122-125 10583731-5 1999 CRF-BP mRNA levels were determined by Northern analysis following 12 h treatment with the following agents: forskolin (1-30 microM), CRF (1-1000 nM), phorbol-12-myristate-13-acetate (TPA; 1-50 nM), dexamethasone (1-100 nM) and IL6 (10-500 pM). Colforsin 108-117 corticotropin releasing hormone binding protein Rattus norvegicus 0-6 10583731-6 1999 Significant increases in CRF-BP mRNA were observed in response to forskolin (30 mM), CRF (100, 1000 nM), IL6 (100, 500 pM), TPA (50 nM) and dexamethasone (100 nM; P<0.05 for all; n=3-6 for all). Colforsin 66-75 corticotropin releasing hormone binding protein Rattus norvegicus 25-31 10583731-8 1999 Twenty-four hour treatment with 30 microM forskolin, 1000 nM CRF, 50 nM TPA, 100 pM IL6 or 100 nM dexamethasone significantly increased CRF-BP expression (P<0.05, n=3 for each treatment). Colforsin 42-51 corticotropin releasing hormone binding protein Rattus norvegicus 136-142 10612708-6 1999 Further, experiments on cultured cells transfected with nociceptin receptor cDNA show that NalBzoH competes [3H]-nociceptin binding and attenuates the nociceptin-induced inhibition of cAMP accumulation induced by forskolin. Colforsin 213-222 opioid receptor-like 1 Mus musculus 56-75 10588449-11 1999 Forskolin and choleratoxin stimulated ALP activity and cyclic AMP formation in a concentration-dependent manner, without affecting cell number. Colforsin 0-9 alopecia, recessive Mus musculus 38-41 10570057-11 1999 These results collectively demonstrate that a 3.4-kb PvuII fragment of the murine alpha(1B)AR gene promoter can: 1) drive tissue-specific production of a CAT reporter in both clonal and primary cell lines; and 2) confer tissue-specific regulation of that CAT reporter when induced by challenge with forskolin and/or hypoxic conditions. Colforsin 299-308 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 82-90 10600091-6 1999 Incubation of BSMC with forskolin 5 microM, for 1 hour before TNF-alpha, decreased TNF-alpha-induced expression of ICAM-1 by 62% and VCAM-1 slightly by 17%. Colforsin 24-33 tumor necrosis factor Homo sapiens 62-71 10600091-6 1999 Incubation of BSMC with forskolin 5 microM, for 1 hour before TNF-alpha, decreased TNF-alpha-induced expression of ICAM-1 by 62% and VCAM-1 slightly by 17%. Colforsin 24-33 tumor necrosis factor Homo sapiens 83-92 10600091-6 1999 Incubation of BSMC with forskolin 5 microM, for 1 hour before TNF-alpha, decreased TNF-alpha-induced expression of ICAM-1 by 62% and VCAM-1 slightly by 17%. Colforsin 24-33 intercellular adhesion molecule 1 Homo sapiens 115-121 10600091-6 1999 Incubation of BSMC with forskolin 5 microM, for 1 hour before TNF-alpha, decreased TNF-alpha-induced expression of ICAM-1 by 62% and VCAM-1 slightly by 17%. Colforsin 24-33 vascular cell adhesion molecule 1 Homo sapiens 133-139 10619397-6 1999 Treatment by forskolin or 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a 1.5- and 10-fold increase, respectively, in SgII mRNA levels in SH-SY5Y cells but not in AtT-20 cells. Colforsin 13-22 secretogranin II Homo sapiens 122-126 10619397-11 1999 Forskolin and TPA stimulated the activity of a SgII-luciferase fusion gene in SH-SY5Y but not in AtT-20 cells. Colforsin 0-9 secretogranin II Homo sapiens 47-51 10563809-3 1999 Recently, YC-1, a novel activator of the heterodimeric soluble GC (sGC), has been identified which acts like forskolin on AC. Colforsin 109-118 RNA binding motif single stranded interacting protein 1 Homo sapiens 10-14 10563809-7 1999 Conceivably, this domain which corresponds to the forskolin site of the ACs may comprise the binding site for YC-1. Colforsin 50-59 RNA binding motif single stranded interacting protein 1 Homo sapiens 110-114 10542109-4 1999 Further, we demonstrate that gastrin-releasing peptide, which activates a Gq-coupled GRP receptor, isoproterenol, which activates a Gs-coupled beta-adrenergic receptor, calcium ionophores, and phorbol 12-myristate 13-acetate, a stimulator of protein kinase C, can mediate increases in luciferase expression in the presence of forskolin but not in its absence. Colforsin 326-335 gastrin releasing peptide Homo sapiens 29-54 10551851-7 1999 We demonstrate that in Y1 cells, forskolin-induced MVDP expression enhanced NADH-linked ICR activity by 5-6-fold, whereas no variation in ICR-linked NADPH activity was observed in the same experiment. Colforsin 33-42 aldo-keto reductase family 1, member B7 Mus musculus 51-55 10551851-8 1999 In cells stably transfected with MVDP antisense cDNA, NADH-linked ICR activity was abolished even in the presence of forskolin, and the isocaproaldehyde toxicity was increased compared with that of intact Y1 cells, as measured by isocaproaldehyde LD(50). Colforsin 117-126 aldo-keto reductase family 1, member B7 Mus musculus 33-37 10551851-9 1999 In Y1 cells transfected with MVDP antisense cDNA, forskolin-induced toxicity was abolished by aminoglutethimide. Colforsin 50-59 aldo-keto reductase family 1, member B7 Mus musculus 29-33 10564094-10 1999 LZQ was used to measure forskolin-stimulated I(-)/Cl(-) and I(-)/NO(-)(3) exchange in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing cell lines by fluorescence microscopy and microplate reader instrumentation using 96-well plates. Colforsin 24-33 CF transmembrane conductance regulator Homo sapiens 86-137 10564094-10 1999 LZQ was used to measure forskolin-stimulated I(-)/Cl(-) and I(-)/NO(-)(3) exchange in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing cell lines by fluorescence microscopy and microplate reader instrumentation using 96-well plates. Colforsin 24-33 CF transmembrane conductance regulator Homo sapiens 139-143 10556144-6 1999 The adenylate cyclase activator, forskolin, also inhibited LPS-induced changes in TNF-alpha and lipid peroxidation. Colforsin 33-42 tumor necrosis factor Homo sapiens 82-91 10548524-8 1999 The adenylate cyclase agonist forskolin lowered the PTHrP mRNA dose-dependently. Colforsin 30-39 parathyroid hormone like hormone Homo sapiens 52-57 10555036-7 1999 The cAMP mimetics, 3-isobutyl-1-methyl xanthine plus forskolin, completely blocked IL-17-induced NO production. Colforsin 53-62 interleukin 17A Homo sapiens 83-88 10497313-5 1999 TSH or forskolin increased the levels of c-myc, jun B, jun D, c-fos, and fos B while decreasing those of c-jun and egr1. Colforsin 7-16 MYC proto-oncogene, bHLH transcription factor Canis lupus familiaris 41-46 10537148-6 1999 In cultured granulosa cells, both human CG and forskolin induced PR and PACAP mRNA levels in a dose-dependent manner, as determined by semi-quantitative RT-PCR assays. Colforsin 47-56 adenylate cyclase activating polypeptide 1 Homo sapiens 72-77 10497313-5 1999 TSH or forskolin increased the levels of c-myc, jun B, jun D, c-fos, and fos B while decreasing those of c-jun and egr1. Colforsin 7-16 JUNB Canis lupus familiaris 48-53 10497313-5 1999 TSH or forskolin increased the levels of c-myc, jun B, jun D, c-fos, and fos B while decreasing those of c-jun and egr1. Colforsin 7-16 JunD proto-oncogene, AP-1 transcription factor subunit Canis lupus familiaris 55-60 10497313-5 1999 TSH or forskolin increased the levels of c-myc, jun B, jun D, c-fos, and fos B while decreasing those of c-jun and egr1. Colforsin 7-16 Fos proto-oncogene, AP-1 transcription factor subunit Canis lupus familiaris 64-67 10497313-5 1999 TSH or forskolin increased the levels of c-myc, jun B, jun D, c-fos, and fos B while decreasing those of c-jun and egr1. Colforsin 7-16 Fos proto-oncogene, AP-1 transcription factor subunit Canis lupus familiaris 73-76 10497313-5 1999 TSH or forskolin increased the levels of c-myc, jun B, jun D, c-fos, and fos B while decreasing those of c-jun and egr1. Colforsin 7-16 Jun proto-oncogene, AP-1 transcription factor subunit Canis lupus familiaris 105-110 10497313-5 1999 TSH or forskolin increased the levels of c-myc, jun B, jun D, c-fos, and fos B while decreasing those of c-jun and egr1. Colforsin 7-16 early growth response 1 Canis lupus familiaris 115-119 10497313-19 1999 (5) fos B, which is induced by TSH, forskolin, phorbol ester, and HGF but not by insulin, could be involved in the mitogenic action of the former factors. Colforsin 36-45 Fos proto-oncogene, AP-1 transcription factor subunit Canis lupus familiaris 4-7 10525543-11 1999 In agreement with this, 4N1K evoked a rapid decrease in cAMP levels which was intensified in the presence of collagen, and forskolin and 8-Br-cAMP both inhibited SMC migration stimulated via IAP. Colforsin 123-132 CD47 molecule Homo sapiens 191-194 10562469-4 1999 Treatment with 10 or 50 microM forskolin resulted in a 20-60% reduction of expression for HSD17B1 (encoding 17beta-HSD I) in T and B lymphoid cell lines and peripheral blood mononuclear cells, although such a change was not observed in the expression of SRD5A1 (encoding 5alpha-reductase I). Colforsin 31-40 hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens 90-97 10562469-4 1999 Treatment with 10 or 50 microM forskolin resulted in a 20-60% reduction of expression for HSD17B1 (encoding 17beta-HSD I) in T and B lymphoid cell lines and peripheral blood mononuclear cells, although such a change was not observed in the expression of SRD5A1 (encoding 5alpha-reductase I). Colforsin 31-40 steroid 5 alpha-reductase 1 Homo sapiens 254-260 10531359-11 1999 Two cAMP-elevating agents, forskolin and cholera toxin, potentiated the LPS-induced NO release and iNOS expression. Colforsin 27-36 nitric oxide synthase 2 Homo sapiens 99-103 10612435-8 1999 Cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) messenger RNA (mRNA) accumulation was stimulated by FSH, 8-bromo-cAMP (8Br-cAMP, 0.5 mM) and forskolin. Colforsin 158-167 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 56-63 10537047-4 1999 AA-NAT mRNA levels were elevated by acute treatment with cyclic AMP protagonists, including forskolin; this response was blocked by H-89, a selective inhibitor of cyclic AMP-dependent protein kinase. Colforsin 92-101 aralkylamine N-acetyltransferase Gallus gallus 0-6 10537047-6 1999 Forskolin-induced elevation of AA-NAT mRNA levels was enhanced by cycloheximide, which decreased the degradation of the transcript in cells treated with actinomycin D. Colforsin 0-9 aralkylamine N-acetyltransferase Gallus gallus 31-37 10598790-3 1999 The five human somatostatin receptor subtypes (hsst1-5) were stably expressed in CCL39 cells (Chinese hamster lung fibroblast cells) to study the inhibition of forskolin-stimulated adenylate cyclase (FSAC) activity induced by somatostatin (somatotropin release inhibiting factor, SRIF), cortistatin (CST) and SRIF peptide analogues. Colforsin 160-169 somatostatin Cricetulus griseus 15-27 10612422-5 1999 Both forskolin and PMA increased bFGF mRNA expression significantly and melatonin was able to inhibit these effects partially, however there was no independent effect of melatonin on bFGF mRNA levels. Colforsin 5-14 fibroblast growth factor 2 Rattus norvegicus 33-37 10816662-8 1999 CRH production was enhanced by ultraviolet light radiation and forskolin (a stimulator for intracellular cAMP production), and inhibited by dexamethasone. Colforsin 63-72 corticotropin releasing hormone Homo sapiens 0-3 10502413-8 1999 In the second approach PKA dominant negative stable clones of MDA-MB-157 treated with CT + IBMX or forskolin also resulted in p21 induction, in the absence of any PKA activity. Colforsin 99-108 H3 histone pseudogene 16 Homo sapiens 126-129 10516213-4 1999 A beta-adrenergic agonist and cAMP mimicked the forskolin action. Colforsin 48-57 amyloid beta precursor protein Rattus norvegicus 0-6 10506130-6 1999 Cbfa1 inhibition was paralleled by an inhibitory effect of forskolin on Cbfa1-regulated genes. Colforsin 59-68 RUNX family transcription factor 2 Homo sapiens 0-5 10506130-6 1999 Cbfa1 inhibition was paralleled by an inhibitory effect of forskolin on Cbfa1-regulated genes. Colforsin 59-68 RUNX family transcription factor 2 Homo sapiens 72-77 10506130-7 1999 Northern and Western blot analyses suggested that the inhibition of Cbfa1 by forskolin was mainly at the protein level. Colforsin 77-86 RUNX family transcription factor 2 Homo sapiens 68-73 10506130-9 1999 Furthermore, addition of proteasome inhibitors to forskolin-pretreated samples resulted in recovery of Cbfa1 protein levels and accumulation of polyubiquitinated forms of Cbfa1, indicating a role for the proteasome pathway in the degradation of Cbfa1. Colforsin 50-59 RUNX family transcription factor 2 Homo sapiens 103-108 10506130-9 1999 Furthermore, addition of proteasome inhibitors to forskolin-pretreated samples resulted in recovery of Cbfa1 protein levels and accumulation of polyubiquitinated forms of Cbfa1, indicating a role for the proteasome pathway in the degradation of Cbfa1. Colforsin 50-59 RUNX family transcription factor 2 Homo sapiens 171-176 10506130-9 1999 Furthermore, addition of proteasome inhibitors to forskolin-pretreated samples resulted in recovery of Cbfa1 protein levels and accumulation of polyubiquitinated forms of Cbfa1, indicating a role for the proteasome pathway in the degradation of Cbfa1. Colforsin 50-59 RUNX family transcription factor 2 Homo sapiens 171-176 10516113-2 1999 In HeLa cells recombinantly expressing the trafficking-competent G551D-CFTR, the forskolin-stimulated Cl currents were small, and average open probability of G551D-CFTR was P(o) = 0.047 +/- 0.019. Colforsin 81-90 CF transmembrane conductance regulator Homo sapiens 71-75 10516113-2 1999 In HeLa cells recombinantly expressing the trafficking-competent G551D-CFTR, the forskolin-stimulated Cl currents were small, and average open probability of G551D-CFTR was P(o) = 0.047 +/- 0.019. Colforsin 81-90 CF transmembrane conductance regulator Homo sapiens 164-168 10496950-7 1999 5-HT resulted in strong inhibition of forskolin-amplified adenylyl cyclase in intact cells expressing the isolated 5-HT(1A) receptor. Colforsin 38-47 5-hydroxytryptamine receptor 1A Homo sapiens 115-132 10493914-2 1999 The alpha(2A)AR-mediated inhibition of forskolin-stimulated cAMP accumulation was completely ablated by CTX pretreatment only after additional treatment with PMA. Colforsin 39-48 adrenoceptor alpha 2A Rattus norvegicus 4-15 10564368-10 1999 Furthermore, pretreatment of the neurons with the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), attenuated the N/OFQ inhibition of the calcium channel current whereas the cAMP-dependent kinase A activator, forskolin, showed no effect, suggesting the probable involvement of PKC in the N/OFQ-induced desensitization. Colforsin 233-242 protein kinase C, gamma Rattus norvegicus 50-66 10564368-10 1999 Furthermore, pretreatment of the neurons with the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), attenuated the N/OFQ inhibition of the calcium channel current whereas the cAMP-dependent kinase A activator, forskolin, showed no effect, suggesting the probable involvement of PKC in the N/OFQ-induced desensitization. Colforsin 233-242 protein kinase C, gamma Rattus norvegicus 68-71 10499519-9 1999 In contrast, the IGFBP-5 expression induced by forskolin was unaffected by PKC down-regulation or inhibition, suggesting that PKC activation is required for the IGF-regulated but not the cAMP-regulated events. Colforsin 47-56 insulin like growth factor binding protein 5 Homo sapiens 17-24 10499519-9 1999 In contrast, the IGFBP-5 expression induced by forskolin was unaffected by PKC down-regulation or inhibition, suggesting that PKC activation is required for the IGF-regulated but not the cAMP-regulated events. Colforsin 47-56 proline rich transmembrane protein 2 Homo sapiens 126-129 10570970-6 1999 An increase of cellular cyclic AMP levels by forskolin treatment up-regulates prepro-nociceptin transcription. Colforsin 45-54 prepronociceptin Homo sapiens 85-95 10501833-5 1999 The transient [Ca(2+)](i) increase produced by ATP or UTP could be mimicked by activation of CFTR with forskolin (20 microm) in CHO-CFTR confluent monolayers. Colforsin 103-112 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 93-97 10501833-5 1999 The transient [Ca(2+)](i) increase produced by ATP or UTP could be mimicked by activation of CFTR with forskolin (20 microm) in CHO-CFTR confluent monolayers. Colforsin 103-112 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 132-136 10501833-8 1999 (100 microm), and with hexokinase (0.28 U/mg) inhibited the [Ca(2+)](i) response to forskolin in CHO-CFTR infected cells. Colforsin 84-93 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 101-105 10508224-3 1999 AC activity was determined by the conversion of substrate ATP into cyclic AMP under basal conditions and in the presence of guanine nucleotide or forskolin. Colforsin 146-155 adenylate cyclase 1 Homo sapiens 0-2 10508224-5 1999 Our results indicate that endometrial AC was highly responsive to activation by both guanine nucleotide and forskolin and its rate of cyclic AMP production was highly pronounced. Colforsin 108-117 adenylate cyclase 1 Homo sapiens 38-40 10481072-4 1999 These mice were mated with the G alpha q transgenics resulting in animals (ACV/G alpha q) that had restored levels of forskolin stimulated AC activities in cardiac membranes. Colforsin 118-127 guanine nucleotide binding protein, alpha q polypeptide Mus musculus 31-40 10555560-4 1999 This inhibition was increased by stimulation (isobutylmethylxanthine, forskolin) of CFTR in cells expressing WT CFTR. Colforsin 70-79 CF transmembrane conductance regulator Bos taurus 84-88 10555560-4 1999 This inhibition was increased by stimulation (isobutylmethylxanthine, forskolin) of CFTR in cells expressing WT CFTR. Colforsin 70-79 CF transmembrane conductance regulator Bos taurus 112-116 10549794-4 1999 Chronic treatment of 293/ORL1 cells with nociceptin/OFQ resulted in enhanced AC activity in response to forskolin stimulation. Colforsin 104-113 opioid related nociceptin receptor 1 Homo sapiens 25-29 10549794-4 1999 Chronic treatment of 293/ORL1 cells with nociceptin/OFQ resulted in enhanced AC activity in response to forskolin stimulation. Colforsin 104-113 prepronociceptin Homo sapiens 41-51 10549794-4 1999 Chronic treatment of 293/ORL1 cells with nociceptin/OFQ resulted in enhanced AC activity in response to forskolin stimulation. Colforsin 104-113 prepronociceptin Homo sapiens 52-55 10488122-7 1999 In EDG7- or EDG4-expressing Sf9 cells, LPA stimulated forskolin-induced increase in intracellular cAMP levels, which was not observed in EDG2-expressing cells. Colforsin 54-63 lysophosphatidic acid receptor 3 Rattus norvegicus 3-7 10488122-7 1999 In EDG7- or EDG4-expressing Sf9 cells, LPA stimulated forskolin-induced increase in intracellular cAMP levels, which was not observed in EDG2-expressing cells. Colforsin 54-63 lysophosphatidic acid receptor 2 Rattus norvegicus 12-16 10488122-7 1999 In EDG7- or EDG4-expressing Sf9 cells, LPA stimulated forskolin-induced increase in intracellular cAMP levels, which was not observed in EDG2-expressing cells. Colforsin 54-63 lysophosphatidic acid receptor 1 Rattus norvegicus 137-141 10546560-0 1999 Effects of BAPTA-AM and forskolin on apoptosis and cytochrome c release in photosensitized Chinese hamster V79 cells. Colforsin 24-33 cytochrome c Cricetulus griseus 51-63 10488078-6 1999 Furthermore, the adenylate cyclase activator forskolin that leads to PKA activation (400 microM, 60 min), shifted HERG wild type channel activation by 14.1 mV and reduced currents by 39.9%, whereas HERG 4M channels showed only a small shift of 4.3 mV and a weaker current reduction of 22.3%. Colforsin 45-54 potassium voltage-gated channel subfamily H member 2 Homo sapiens 114-118 10488078-6 1999 Furthermore, the adenylate cyclase activator forskolin that leads to PKA activation (400 microM, 60 min), shifted HERG wild type channel activation by 14.1 mV and reduced currents by 39.9%, whereas HERG 4M channels showed only a small shift of 4.3 mV and a weaker current reduction of 22.3%. Colforsin 45-54 potassium voltage-gated channel subfamily H member 2 Homo sapiens 198-202 10481072-4 1999 These mice were mated with the G alpha q transgenics resulting in animals (ACV/G alpha q) that had restored levels of forskolin stimulated AC activities in cardiac membranes. Colforsin 118-127 guanine nucleotide binding protein, alpha q polypeptide Mus musculus 79-88 10484345-4 1999 Treatment with 0.5 microM thrombin increased transendothelial albumin clearance rate (0.012 +/- 0.003 and 0.035 +/- 0.005 microl/min for control and thrombin, respectively); the increase was prevented with forskolin + 3-isobutyl-1-methylxanthine (F + I) treatment. Colforsin 206-215 coagulation factor II, thrombin Homo sapiens 26-34 10507539-4 1999 On the other hand, stimulation of PKA by forskolin had a weak suppressive effect on NeuroD mRNA expression. Colforsin 41-50 neuronal differentiation 1 Homo sapiens 84-90 10456845-7 1999 Northern blot analysis revealed that RTP mRNA expression was induced to 3-fold in BeWo after 24-h incubation with forskolin and increased up to 11-fold by 72 h of forskolin treatment. Colforsin 114-123 N-myc downstream regulated 1 Homo sapiens 37-40 10456845-7 1999 Northern blot analysis revealed that RTP mRNA expression was induced to 3-fold in BeWo after 24-h incubation with forskolin and increased up to 11-fold by 72 h of forskolin treatment. Colforsin 163-172 N-myc downstream regulated 1 Homo sapiens 37-40 10455028-8 1999 Forskolin/IBMX inhibited the growth factor-induced expression of c-myc mRNA and cyclin D(1) protein, and enhanced the protein expression of p27(kip1). Colforsin 0-9 myc proto-oncogene protein Oryctolagus cuniculus 65-70 10465281-3 1999 Forskolin (Fsk, 10 microM) or 12-O-tetradecanoyl-phorbol 13-acetate (TPA, 100 nM) increases CRH-BP mRNA levels up to 30 times control level, and together they act synergistically to increase CRH-BP gene expression up to 100 times control levels. Colforsin 0-9 corticotropin releasing hormone binding protein Rattus norvegicus 92-98 10455028-8 1999 Forskolin/IBMX inhibited the growth factor-induced expression of c-myc mRNA and cyclin D(1) protein, and enhanced the protein expression of p27(kip1). Colforsin 0-9 G1/S-specific cyclin-D2 Oryctolagus cuniculus 80-91 10465260-8 1999 The same observations as with GLP-1 were made when adenylate cyclase was stimulated with forskolin, for selective examination of signal transduction downstream of receptor and G protein. Colforsin 89-98 glucagon Mus musculus 30-35 10510460-6 1999 3 In CHOmu cells, E-1/E-2 inhibited forskolin (1 microM) stimulated cyclic AMP formation with pIC50 values of 8.03+/-0.16 (Imax = 53.0+/-9. Colforsin 36-45 small nucleolar RNA, H/ACA box 73A Homo sapiens 18-25 10465281-3 1999 Forskolin (Fsk, 10 microM) or 12-O-tetradecanoyl-phorbol 13-acetate (TPA, 100 nM) increases CRH-BP mRNA levels up to 30 times control level, and together they act synergistically to increase CRH-BP gene expression up to 100 times control levels. Colforsin 11-14 corticotropin releasing hormone binding protein Rattus norvegicus 92-98 10465281-3 1999 Forskolin (Fsk, 10 microM) or 12-O-tetradecanoyl-phorbol 13-acetate (TPA, 100 nM) increases CRH-BP mRNA levels up to 30 times control level, and together they act synergistically to increase CRH-BP gene expression up to 100 times control levels. Colforsin 11-14 corticotropin releasing hormone binding protein Rattus norvegicus 191-197 10465281-7 1999 CRH-BP hnRNA transcripts can be detected transiently after the addition of Fsk or TPA, and dexamethasone can repress Fsk- or TPA-induced CRH-BP hnRNA levels in this assay. Colforsin 75-78 corticotropin releasing hormone binding protein Rattus norvegicus 0-6 10465281-3 1999 Forskolin (Fsk, 10 microM) or 12-O-tetradecanoyl-phorbol 13-acetate (TPA, 100 nM) increases CRH-BP mRNA levels up to 30 times control level, and together they act synergistically to increase CRH-BP gene expression up to 100 times control levels. Colforsin 0-9 corticotropin releasing hormone binding protein Rattus norvegicus 191-197 10465281-7 1999 CRH-BP hnRNA transcripts can be detected transiently after the addition of Fsk or TPA, and dexamethasone can repress Fsk- or TPA-induced CRH-BP hnRNA levels in this assay. Colforsin 117-120 corticotropin releasing hormone binding protein Rattus norvegicus 137-143 10465306-0 1999 Expression and function of estrogen receptor subtypes in granulosa cells: regulation by estradiol and forskolin. Colforsin 102-111 estrogen receptor 1 Rattus norvegicus 27-44 10487706-10 1999 The repressive action of TSH on MMP-1 mRNA was mimicked by forskolin and 8-bromo-cAMP and was abrogated by the PKA inhibitor, H-89, suggesting that the TSH inhibitory action is PKA-mediated. Colforsin 59-68 matrix metallopeptidase 1 Homo sapiens 32-37 10521580-2 1999 Treatment of primary Schwann cells with the adenylate cyclase activator, forskolin, or the cAMP agonist, 8-Br-cAMP, induced a significant reduction in NT-3 transcript levels. Colforsin 73-82 neurotrophin 3 Homo sapiens 151-155 10454503-5 1999 CYP3A-induced expression was inhibited by activators of cyclic AMP-dependent protein kinase (PKA) (dibutyryl-cyclic AMP and forskolin) whereas inhibition of PKA by PKA inhibitor enhanced induction. Colforsin 124-133 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 0-5 10521580-5 1999 The TGF-beta1, GGF(2) and forskolin dependent reduction in NT-3 mRNA levels involved a destabilization of transcripts which was antagonised by co-treatment with cycloheximide. Colforsin 26-35 neurotrophin 3 Rattus norvegicus 59-63 10521580-6 1999 The cAMP-dependent protein kinase A (PKA) inhibitor, H-89, blocked the reduction in levels of NT-3 mRNA induced by TGF-beta1, GGF(2) and forskolin. Colforsin 137-146 neurotrophin 3 Rattus norvegicus 94-98 10521580-7 1999 The data show that the effects of TGF-beta1, GGF(2) and forskolin on the downregulation of NT-3 mRNA, at least in part, were due to a post-transcriptional event involving a labile protein intermediate under the control of PKA. Colforsin 56-65 neurotrophin 3 Rattus norvegicus 91-95 10446213-10 1999 The cell-permeable cAMP analog 8-bromo-cAMP and the adenylate cyclase activator forskolin both induce LPL phosphorylation in cells. Colforsin 80-89 lymphocyte cytosolic protein 1 Homo sapiens 102-105 10441476-3 1999 The extract of rat whole brain showed inhibition of intracellular forskolin-induced cAMP accumulation in rat SLC-1-expressing CHO cells and was purified. Colforsin 66-75 melanin-concentrating hormone receptor 1 Rattus norvegicus 109-114 10509796-5 1999 The overproduction of the transcriptionally inactive form of NGFI-B in thyrocytes maintained in the presence of forskolin after infection did not impair the accumulation of the thyroid-specific transcripts. Colforsin 112-121 nuclear receptor subfamily 4 group A member 1 Canis lupus familiaris 61-67 10451362-14 1999 Consistent with its proposed role as a nuclear transcriptional factor, transient expression of MINT(1-812) suppresses the FGF/forskolin-activated OC promoter, does not significantly regulate CMV promoter activity, but markedly upregulates the HSV thymidine kinase promoter in MC3T3E1 cells. Colforsin 126-135 spen family transcription repressor Mus musculus 95-99 10441476-5 1999 The authentic MCH demonstrated a dose-dependent inhibitory effect on cAMP accumulation in forskolin-stimulated rat and human SLC-1-expressing CHO cells with an EC(50) value of 0.2 nM for both the rat and human SLC-1 receptors. Colforsin 90-99 melanin concentrating hormone receptor 1 Homo sapiens 125-130 10417318-6 1999 Phosphorylation of phogrin was also stimulated in cells exposed to forskolin, an effect presumably mediated by protein kinase A (cAMP-dependent protein kinase). Colforsin 67-76 protein tyrosine phosphatase, receptor type, N polypeptide 2 Mus musculus 19-26 10441476-5 1999 The authentic MCH demonstrated a dose-dependent inhibitory effect on cAMP accumulation in forskolin-stimulated rat and human SLC-1-expressing CHO cells with an EC(50) value of 0.2 nM for both the rat and human SLC-1 receptors. Colforsin 90-99 melanin concentrating hormone receptor 1 Homo sapiens 210-215 10444407-5 1999 A 30-50% suppression in the autophosphorylation and the kinase activity of p59(fyn) in T cells incubated with PGE(2) or forskolin was observed. Colforsin 120-129 FKBP prolyl isomerase 4 Rattus norvegicus 75-78 10444407-5 1999 A 30-50% suppression in the autophosphorylation and the kinase activity of p59(fyn) in T cells incubated with PGE(2) or forskolin was observed. Colforsin 120-129 FYN proto-oncogene, Src family tyrosine kinase Rattus norvegicus 79-82 10454705-8 1999 Treatment of BeWo cells with the receptor agonist blocked the activity of the constitutive, as well as the forskolin-induced, serotonin transporter without affecting the serotonin transporter density. Colforsin 107-116 solute carrier family 6 member 4 Homo sapiens 126-147 10433805-4 1999 In RIN5F cells, the activity of iNOS induced by IL-1beta (10 pM, 24 h), was significantly reduced by glucagon (1000 nM), which raises cyclic AMP, and by forskolin (1-10 microM), a non specific activator of adenylate cyclase. Colforsin 153-162 nitric oxide synthase 2, inducible Mus musculus 32-36 10433805-4 1999 In RIN5F cells, the activity of iNOS induced by IL-1beta (10 pM, 24 h), was significantly reduced by glucagon (1000 nM), which raises cyclic AMP, and by forskolin (1-10 microM), a non specific activator of adenylate cyclase. Colforsin 153-162 interleukin 1 beta Mus musculus 48-56 10433805-5 1999 Glucagon and forskolin also decreased iNOS expression in RIN5F cells, and rat and human islets, as shown by Western blotting. Colforsin 13-22 nitric oxide synthase 2, inducible Mus musculus 38-42 10413674-7 1999 Treatment with colchicine or forskolin induced the association of E-cadherin to the cytoskeleton fraction of subconfluent HT29 cells. Colforsin 29-38 cadherin 1 Homo sapiens 66-76 10433200-4 1999 When this sequence was deleted, the GnRHR promoter activity was significantly increased in both basal and GnRH agonist (Buserelin)-, phorbol ester-, and forskolin-stimulated cells. Colforsin 153-162 gonadotropin releasing hormone receptor Mus musculus 36-41 10433214-14 1999 However, GHRH and forskolin reduced GHRH-R mRNA levels by 40% (P < 0.05). Colforsin 18-27 growth hormone releasing hormone receptor Rattus norvegicus 36-42 10580739-8 1999 Both tetradecanoyl phorbol acetate (TPA), and forskolin increased PTH-rP mRNA levels and the PTH-rP production in amnion cells, and the effect of TPA was much greater than that of forskolin. Colforsin 46-55 parathyroid hormone like hormone Homo sapiens 66-72 10580739-8 1999 Both tetradecanoyl phorbol acetate (TPA), and forskolin increased PTH-rP mRNA levels and the PTH-rP production in amnion cells, and the effect of TPA was much greater than that of forskolin. Colforsin 46-55 parathyroid hormone like hormone Homo sapiens 93-99 10432398-8 1999 On the other hand, forskolin, db-cAMP, and 11-deoxy-PGE1, an EP4/EP3/EP2 agonist, significantly decreased DNA synthesis in MCs. Colforsin 19-28 prostaglandin E receptor 4 Rattus norvegicus 61-64 10458598-7 1999 In all cultures, sumatriptan inhibited (35-58%, P < .05) the forskolin-stimulated production of cyclic AMP, an effect blocked by the 5-HT1B/1D receptor antagonists GR127935 and GR55562. Colforsin 64-73 5-hydroxytryptamine receptor 1B Homo sapiens 136-142 10432398-8 1999 On the other hand, forskolin, db-cAMP, and 11-deoxy-PGE1, an EP4/EP3/EP2 agonist, significantly decreased DNA synthesis in MCs. Colforsin 19-28 prostaglandin E receptor 3 Rattus norvegicus 65-68 10432398-8 1999 On the other hand, forskolin, db-cAMP, and 11-deoxy-PGE1, an EP4/EP3/EP2 agonist, significantly decreased DNA synthesis in MCs. Colforsin 19-28 prostaglandin E receptor 2 Rattus norvegicus 69-72 10419552-3 1999 N/OFQ and N/OFQ(1-13)NH(2) inhibited the forskolin-induced luciferase gene expression with IC(50) values of 0.81 +/- 0.5 and 0.87 +/- 0.16 nM, respectively. Colforsin 41-50 prepronociceptin Homo sapiens 0-5 10419552-3 1999 N/OFQ and N/OFQ(1-13)NH(2) inhibited the forskolin-induced luciferase gene expression with IC(50) values of 0.81 +/- 0.5 and 0.87 +/- 0.16 nM, respectively. Colforsin 41-50 prepronociceptin Homo sapiens 10-15 10482244-5 1999 Administration of forskolin to area CA1 before training restored normal LTM. Colforsin 18-27 carbonic anhydrase 1 Mus musculus 36-39 10446909-4 1999 However, granulosa cells expressing CREB M1, but not adenovirus-directed beta-galactosidase or enhanced green fluorescent protein, exhibited a 35% reduction in viability that was further reduced to 65% after stimulation with 10 microM forskolin. Colforsin 235-244 cAMP responsive element binding protein 1 Rattus norvegicus 36-40 10446906-12 1999 Aromatase, Sgk, and phospho-CREB were expressed at elevated levels in a non-forskolin-responsive manner. Colforsin 76-85 cAMP responsive element binding protein 1 Rattus norvegicus 28-32 10419452-7 1999 Expression of chick Rap1GAP in PC-12 cells inhibited activation of Rap1 by forskolin. Colforsin 75-84 RAP1 GTPase activating protein 1 Gallus gallus 20-27 10657504-3 1999 Dopamine inhibited forskolin-stimulated accumulation of cAMP in the intermediate lobe of Cpe(fat)/ Cpe(fat)mice, showing that their dopamine receptors were fully functional. Colforsin 19-28 carboxypeptidase E Mus musculus 89-92 10657504-3 1999 Dopamine inhibited forskolin-stimulated accumulation of cAMP in the intermediate lobe of Cpe(fat)/ Cpe(fat)mice, showing that their dopamine receptors were fully functional. Colforsin 19-28 carboxypeptidase E Mus musculus 99-102 12567455-6 1999 RESULTS: Stimulation of forskolin (30 mumol/L) plus 3-isobutyl-1-methyl-xanthine (IBMX, 30 mumol/L) which induced the accumulation of cellular cAMP decreased the expression of AT1 receptor mRNA to (64.4 +/- 20.3)% of control at 6 h treatment; while it increased the expression of AT1 receptor mRNA to (209.6 +/- 24.0)% of control at 48 h treatment. Colforsin 24-33 angiotensin II receptor, type 1a Rattus norvegicus 176-179 12567455-6 1999 RESULTS: Stimulation of forskolin (30 mumol/L) plus 3-isobutyl-1-methyl-xanthine (IBMX, 30 mumol/L) which induced the accumulation of cellular cAMP decreased the expression of AT1 receptor mRNA to (64.4 +/- 20.3)% of control at 6 h treatment; while it increased the expression of AT1 receptor mRNA to (209.6 +/- 24.0)% of control at 48 h treatment. Colforsin 24-33 angiotensin II receptor, type 1a Rattus norvegicus 280-283 10419452-7 1999 Expression of chick Rap1GAP in PC-12 cells inhibited activation of Rap1 by forskolin. Colforsin 75-84 RAP1 GTPase activating protein 3 Gallus gallus 20-24 10395944-6 1999 hPTP-J transcription was down-regulated not only by PMA but also by several signaling modulators including 1-oleoyl-2-acetylglycerol, forskolin, orthovanadate, manumycin and okadaic acid. Colforsin 134-143 protein tyrosine phosphatase receptor type U Homo sapiens 0-6 10421367-6 1999 Here we show that the 353-amino-acid human orphan G-protein-coupled receptor SLC-1 expressed in HEK293 cells binds MCH with sub-nanomolar affinity, and is stimulated by MCH to mobilize intracellular Ca2+ and reduce forskolin-elevated cyclic AMP levels. Colforsin 215-224 melanin concentrating hormone receptor 1 Homo sapiens 77-82 10421367-6 1999 Here we show that the 353-amino-acid human orphan G-protein-coupled receptor SLC-1 expressed in HEK293 cells binds MCH with sub-nanomolar affinity, and is stimulated by MCH to mobilize intracellular Ca2+ and reduce forskolin-elevated cyclic AMP levels. Colforsin 215-224 pro-melanin concentrating hormone Homo sapiens 169-172 10415364-4 1999 In cultured pineal glands from 4-day-old chicks, cyclic AMP analogs and the adenylate cyclase activator, forskolin, increased HIOMT mRNA levels twofold to threefold in a dose-dependent manner. Colforsin 105-114 acetylserotonin O-methyltransferase Gallus gallus 126-131 10443477-2 1999 In the presence of 10(-4) M amiloride, the addition of VIP to the serosal solution led to an increase in the Isc in a concentration-dependent manner, the 50% effective concentration (EC50) being 2.6 x 10(-11) M. However, the addition of 10(-5) M forskolin had little effect on the increase in Isc. Colforsin 246-255 vasoactive intestinal peptide Homo sapiens 55-58 10395955-7 1999 cAMP elevating agents (forskolin and cholera toxin) mimic the PGE2-induced inhibition of M-CSF production. Colforsin 23-32 colony stimulating factor 1 Homo sapiens 89-94 10406641-1 1999 2-O-Acetyl-D-glucose was synthesized in order to evaluate the influence of an acyl group on the binding with the glucose carrier protein (GluT); as its affinity neighbours that of glucose itself, the glucose-forskolin analogy appears to be coincidental and several explanations are proposed. Colforsin 208-217 solute carrier family 2 member 1 Homo sapiens 113-136 10406641-1 1999 2-O-Acetyl-D-glucose was synthesized in order to evaluate the influence of an acyl group on the binding with the glucose carrier protein (GluT); as its affinity neighbours that of glucose itself, the glucose-forskolin analogy appears to be coincidental and several explanations are proposed. Colforsin 208-217 solute carrier family 2 member 1 Homo sapiens 138-142 10453077-4 1999 In VSMC-E1A, the addition of an activator of adenylate cyclase, forskolin, abolished chromatin cleavage, DNA laddering, caspase-3 activation and the appearance of morphologically-defined apoptotic cells triggered by 6 h of serum deprivation. Colforsin 64-73 caspase 3 Homo sapiens 120-129 10385409-5 1999 Forskolin (a stimulator of cAMP accumulation) also down regulated the PTH-1 receptor, whereas 9-(tetrahydro-2-furyl) adenine (THFA) (an inhibitor of adenylyl cyclase) had no effect. Colforsin 0-9 parathyroid hormone 1 receptor Rattus norvegicus 70-84 10385409-8 1999 In contrast, PTH-stimulated cAMP levels were significantly increased in cultures treated with PTH (7-34) and THFA for 6 days during osteoblast differentiation and were decreased in cultures treated with PTH (1-34) and forskolin compared with controls. Colforsin 218-227 parathyroid hormone Rattus norvegicus 13-16 10419647-6 1999 In addition, elevated cAMP levels were shown to inhibit IP-10 mRNA expression as could be concluded from experiments with forskolin and W-7, substances which, directly or indirectly, raise the intracellular cAMP level. Colforsin 122-131 C-X-C motif chemokine ligand 10 Homo sapiens 56-61 10385419-5 1999 Long term treatment with 8-bromo-cAMP or forskolin resulted in a selective induction of PDE4B and of PDE4D short form messenger RNA variants. Colforsin 41-50 phosphodiesterase 4B Homo sapiens 88-93 10385419-5 1999 Long term treatment with 8-bromo-cAMP or forskolin resulted in a selective induction of PDE4B and of PDE4D short form messenger RNA variants. Colforsin 41-50 phosphodiesterase 4D Homo sapiens 101-106 10385409-10 1999 THFA and PTH (7-34)-treated cultures had increased OCN expression; whereas, PTH (1-34) and forskolin reduced OCN expression. Colforsin 91-100 bone gamma-carboxyglutamate protein Rattus norvegicus 109-112 10386963-3 1999 The proenkephalin gene is a target of cyclic AMP-dependent agonists like forskolin, and its expression is driven by the enhancer element CRE-2. Colforsin 73-82 proenkephalin Homo sapiens 4-17 10362019-3 1999 We show for the first time that forskolin (which increases intracellular levels of cAMP) increases apoptosis in the CD10- cells in a dose-dependent manner (19%-94% with 0-1,000 microM forskolin after 48 hours incubation, IC50 = 150 microM). Colforsin 32-41 membrane metalloendopeptidase Homo sapiens 116-120 10362019-7 1999 We found that treatment of the cells with forskolin or 8-CPT-cAMP for 48 hours resulted in a fourfold decline in the expression of Mcl-1 (n = 6, P = 0.002) compared to control cells. Colforsin 42-51 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 131-136 10395798-7 1999 However, NBPhox substantially enhances second messenger-mediated activation of the DBH promoter by forskolin and/or phorbol ester. Colforsin 99-108 paired like homeobox 2B Homo sapiens 9-15 10395798-7 1999 However, NBPhox substantially enhances second messenger-mediated activation of the DBH promoter by forskolin and/or phorbol ester. Colforsin 99-108 dopamine beta-hydroxylase Homo sapiens 83-86 10386963-9 1999 We have found that the inhibition of src-related nonreceptor tyrosine kinases blocks forskolin-induced proenkephalin gene expression without having any effect on serine-133-phosphorylated CREB levels and that constitutively activated src kinase can activate the proenkephalin promoter. Colforsin 85-94 proenkephalin Homo sapiens 103-116 10386963-9 1999 We have found that the inhibition of src-related nonreceptor tyrosine kinases blocks forskolin-induced proenkephalin gene expression without having any effect on serine-133-phosphorylated CREB levels and that constitutively activated src kinase can activate the proenkephalin promoter. Colforsin 85-94 proenkephalin Homo sapiens 262-275 10373549-6 1999 Moreover, phosphopeptide maps of overexpressed PKB from COS cells showed differences between insulin- and forskolin-stimulated cells that pointed to distinct activation mechanisms of PKB depending on whether insulin or cAMP was used. Colforsin 106-115 protein tyrosine kinase 2 beta Homo sapiens 47-50 10373549-6 1999 Moreover, phosphopeptide maps of overexpressed PKB from COS cells showed differences between insulin- and forskolin-stimulated cells that pointed to distinct activation mechanisms of PKB depending on whether insulin or cAMP was used. Colforsin 106-115 protein tyrosine kinase 2 beta Homo sapiens 183-186 10373549-8 1999 Overexpression of a dominant negative PKB led to the loss of inhibition of GSK-3 in both insulin- and forskolin-treated cells, demonstrating that PKB was responsible for this inhibition in both cases. Colforsin 102-111 protein tyrosine kinase 2 beta Homo sapiens 38-41 10373549-9 1999 Finally, we show by confocal microscopy that forskolin, similar to insulin, was able to induce translocation of PKB to the plasma membrane. Colforsin 45-54 protein tyrosine kinase 2 beta Homo sapiens 112-115 10385697-2 1999 GAL mRNA up-regulation via the protein kinase A (PKA) pathway (25 microM forskolin) required new protein synthesis. Colforsin 73-82 galanin and GMAP prepropeptide Homo sapiens 0-3 10377071-5 1999 When stimulated through the betaAR, cardiac responsiveness was increased (P=0.02), and cardiac myocytes showed increased cAMP production in response to isoproterenol (P=0.03) and forskolin (P<0.0001). Colforsin 179-188 adrenergic receptor, beta 1 Mus musculus 28-34 10370106-9 1999 Successive additions of insulin and forskolin caused additive increases in CT. Because increases in CT and Na+ transport occurred in the absence of stimulation of water permeability and increases of CT and GT were directly proportional when Na+ was the major permeating ion across the apical membrane, we suggest that the increase in apical Na+ permeability in the presence of either forskolin or insulin is due to the insertion of channels residing in intracellular pools. Colforsin 36-45 insulin Homo sapiens 397-404 10370106-9 1999 Successive additions of insulin and forskolin caused additive increases in CT. Because increases in CT and Na+ transport occurred in the absence of stimulation of water permeability and increases of CT and GT were directly proportional when Na+ was the major permeating ion across the apical membrane, we suggest that the increase in apical Na+ permeability in the presence of either forskolin or insulin is due to the insertion of channels residing in intracellular pools. Colforsin 384-393 insulin Homo sapiens 24-31 10406459-0 1999 A dominant role for the Raf-MEK pathway in forskolin, 12-O-tetradecanoyl-phorbol acetate, and platelet-derived growth factor-induced CREB (cAMP-responsive element-binding protein) activation, uncoupled from serine 133 phosphorylation in NIH 3T3 cells. Colforsin 43-52 zinc fingers and homeoboxes 2 Mus musculus 24-27 10406459-0 1999 A dominant role for the Raf-MEK pathway in forskolin, 12-O-tetradecanoyl-phorbol acetate, and platelet-derived growth factor-induced CREB (cAMP-responsive element-binding protein) activation, uncoupled from serine 133 phosphorylation in NIH 3T3 cells. Colforsin 43-52 midkine Mus musculus 28-31 10406459-1 1999 In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells. Colforsin 116-125 cAMP responsive element binding protein 1 Mus musculus 134-138 10406459-1 1999 In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells. Colforsin 116-125 cAMP responsive element binding protein 1 Mus musculus 140-179 10406459-2 1999 While forskolin was the most potent activator of CREB, TPA or PDGF modestly increased CREB activity. Colforsin 6-15 cAMP responsive element binding protein 1 Mus musculus 49-53 10406459-2 1999 While forskolin was the most potent activator of CREB, TPA or PDGF modestly increased CREB activity. Colforsin 6-15 cAMP responsive element binding protein 1 Mus musculus 86-90 10406459-6 1999 We further demonstrate that although inhibition of Raf-MEK represses forskolin-induced CREB activation, forskolin by itself failed to activate ERK1/2 and Elk-1 mediated transcription. Colforsin 69-78 zinc fingers and homeoboxes 2 Mus musculus 51-54 10406459-6 1999 We further demonstrate that although inhibition of Raf-MEK represses forskolin-induced CREB activation, forskolin by itself failed to activate ERK1/2 and Elk-1 mediated transcription. Colforsin 69-78 midkine Mus musculus 55-58 10406459-6 1999 We further demonstrate that although inhibition of Raf-MEK represses forskolin-induced CREB activation, forskolin by itself failed to activate ERK1/2 and Elk-1 mediated transcription. Colforsin 69-78 cAMP responsive element binding protein 1 Mus musculus 87-91 10406459-7 1999 These results suggest that a basal level of Raf-MEK activity is necessary for both PDGF- and forskolin-induced CREB activation, independent of CREB Ser-133 phosphorylation. Colforsin 93-102 zinc fingers and homeoboxes 2 Mus musculus 44-47 10406459-7 1999 These results suggest that a basal level of Raf-MEK activity is necessary for both PDGF- and forskolin-induced CREB activation, independent of CREB Ser-133 phosphorylation. Colforsin 93-102 midkine Mus musculus 48-51 10406459-7 1999 These results suggest that a basal level of Raf-MEK activity is necessary for both PDGF- and forskolin-induced CREB activation, independent of CREB Ser-133 phosphorylation. Colforsin 93-102 cAMP responsive element binding protein 1 Mus musculus 111-115 10359826-6 1999 PTH(1-34) and forskolin stimulated the activity of all constructs to varying degrees with significantly greater responsiveness for both compounds on AN2 and AN5. Colforsin 14-23 paired box 6 Homo sapiens 149-152 10720424-5 1999 The cellular adenosine 3"-5"-cyclic monophosphate (cAMP) concentration positively correlated with PRL concentration in the presence of forskolin or 3-isobutyl-1-methylxanthine (IBMX). Colforsin 135-144 prolactin Rattus norvegicus 98-101 10720424-6 1999 PRL enhanced the stimulatory effects of cAMP mimetic reagents, i.e., forskolin, 8-bromo-adenosine 3",5"-cyclic monophosphate (8-Br-cAMP), and IBMX on the release of corticosterone. Colforsin 69-78 prolactin Rattus norvegicus 0-3 10359826-4 1999 By using luciferase reporter gene constructs of truncated forms of the 1alpha-OHase promoter transfected into a modified pig kidney cell line, AOK-B50, we identified regulatory regions of the 1.4-kb 1alpha-OHase promoter for parathyroid hormone 1-34 [PTH(1-34)], forskolin, and 1,25-hydroxyvitamin D3 [1,25(OH)2D3]. Colforsin 263-272 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 71-83 10336676-8 1999 When cAMP was elevated in mGluR2-expressing cells, by forskolin or dibutyryl-cAMP, slight elevation of ERK activity was observed. Colforsin 54-63 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 26-32 10359826-4 1999 By using luciferase reporter gene constructs of truncated forms of the 1alpha-OHase promoter transfected into a modified pig kidney cell line, AOK-B50, we identified regulatory regions of the 1.4-kb 1alpha-OHase promoter for parathyroid hormone 1-34 [PTH(1-34)], forskolin, and 1,25-hydroxyvitamin D3 [1,25(OH)2D3]. Colforsin 263-272 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 199-211 10433494-10 1999 The results emphasise the importance of the Ser200 and Ser204 residues of the alpha2A-adrenoceptor in exerting an inhibitory influence on the ability of (+/-)-para-octopamine and (+/-)-meta-octopamine respectively, to induce a receptor-agonist conformation capable of inhibiting forskolin-stimulation of cyclic AMP levels. Colforsin 279-288 adrenoceptor alpha 2A Homo sapiens 78-98 10400316-6 1999 C2-ceramide reduced the IL-6 synthesis induced by cholera toxin, forskolin or dibutyryl cAMP. Colforsin 65-74 interleukin 6 Mus musculus 24-28 10374262-8 1999 By contrast, post-confluence treatment of the murine 3T3-L1 cell line with either forskolin or MIX markedly enhanced lipid accumulation and led to a dramatic increase in GPDH activity (up to 120 times). Colforsin 82-91 glycerol phosphate dehydrogenase 2, mitochondrial Mus musculus 170-174 10348817-6 1999 RF inhibited transepithelial cAMP-stimulated Cl- current in T84 cells and inhibited forskolin (i.e., cAMP)-induced current in cells transfected with CFTR. Colforsin 84-93 CF transmembrane conductance regulator Homo sapiens 149-153 10336821-7 1999 In vitro treatment with hCG and protein kinase A (PKA) activators (dbcAMP and forskolin) induced ovarian Cx32.2 mRNA levels and OMC. Colforsin 78-87 hypertrichosis 2 (generalised, congenital) Homo sapiens 24-27 10336518-3 1999 In striatal slices from Adra2c+/+ mice, the alpha2 adrenoceptor antagonist RX821002 facilitated forskolin-stimulated cyclic AMP accumulation in a concentration-dependent manner. Colforsin 96-105 adrenergic receptor, alpha 2c Mus musculus 24-30 10352098-7 1999 In TPXM cells, peptide-specific immunoassays detected high basal levels of PTHrP, increasing by 2-fold in cell extracts and 4-fold in culture media at 7 h and 24 h after exposure to forskolin, respectively, paralleling changes in PTHrP mRNA expression. Colforsin 182-191 parathyroid hormone like hormone Homo sapiens 75-80 10352098-7 1999 In TPXM cells, peptide-specific immunoassays detected high basal levels of PTHrP, increasing by 2-fold in cell extracts and 4-fold in culture media at 7 h and 24 h after exposure to forskolin, respectively, paralleling changes in PTHrP mRNA expression. Colforsin 182-191 parathyroid hormone like hormone Homo sapiens 230-235 10336518-7 1999 Both norepinephrine and dopamine inhibited forskolin-stimulated cAMP accumulation in intact NRK-alpha2C cells. Colforsin 43-52 adrenergic receptor, alpha 2c Mus musculus 96-103 10336536-4 1999 Both ACPA and ACEA have the characteristics of agonists at the CB1 receptor; both inhibit forskolin-induced accumulation of cAMP in Chinese hamster ovary cells expressing the human CB1 receptor, and both analogs increase the binding of [35S]GTPgammaS to cerebellar membranes and inhibit electrically evoked contractions of the mouse vas deferens. Colforsin 90-99 cannabinoid receptor 1 Homo sapiens 63-66 10336536-4 1999 Both ACPA and ACEA have the characteristics of agonists at the CB1 receptor; both inhibit forskolin-induced accumulation of cAMP in Chinese hamster ovary cells expressing the human CB1 receptor, and both analogs increase the binding of [35S]GTPgammaS to cerebellar membranes and inhibit electrically evoked contractions of the mouse vas deferens. Colforsin 90-99 cannabinoid receptor 1 Homo sapiens 181-184 10336518-8 1999 In NRK-alpha2A cells, norepinephrine facilitated forskolin-stimulated cAMP accumulation, an effect not observed for dopamine. Colforsin 49-58 adrenergic receptor, alpha 2a Mus musculus 7-14 10411124-4 1999 TSH/forskolin downregulate ICAM-1 RNA levels independent of the presence or absence of hydrocortisone or insulin. Colforsin 4-13 intercellular adhesion molecule 1 Rattus norvegicus 27-33 10347254-6 1999 Transfection of GPCR97 into a variety of cell lines conferred an ability to inhibit forskolin-stimulated cAMP formation in response to histamine, but not to acetylcholine or any other biogenic amine. Colforsin 84-93 histamine receptor H3 Homo sapiens 16-22 10370087-13 1999 When, however, the monolayers were pre-stimulated by forskolin (1 microM), BK further enhanced Cl-secretion (DeltaIsc=21+/-5 microA/cm2, n=10) transiently and biphasically. Colforsin 53-62 kininogen 1 Homo sapiens 75-77 10411124-5 1999 Moreover, TSH/forskolin decrease ICAM-1 RNA levels that are maximally induced by two cytokines: 100 ng/mL tumor necrosis factor-alpha (TNF-alpha) or 100 U/ml interferon-gamma (IFN-gamma). Colforsin 14-23 intercellular adhesion molecule 1 Rattus norvegicus 33-39 10411124-5 1999 Moreover, TSH/forskolin decrease ICAM-1 RNA levels that are maximally induced by two cytokines: 100 ng/mL tumor necrosis factor-alpha (TNF-alpha) or 100 U/ml interferon-gamma (IFN-gamma). Colforsin 14-23 tumor necrosis factor Rattus norvegicus 135-144 10411124-5 1999 Moreover, TSH/forskolin decrease ICAM-1 RNA levels that are maximally induced by two cytokines: 100 ng/mL tumor necrosis factor-alpha (TNF-alpha) or 100 U/ml interferon-gamma (IFN-gamma). Colforsin 14-23 interferon gamma Rattus norvegicus 158-174 10411124-5 1999 Moreover, TSH/forskolin decrease ICAM-1 RNA levels that are maximally induced by two cytokines: 100 ng/mL tumor necrosis factor-alpha (TNF-alpha) or 100 U/ml interferon-gamma (IFN-gamma). Colforsin 14-23 interferon gamma Rattus norvegicus 176-185 10411124-6 1999 The effect of TSH/forskolin, as well as TNF-alpha and IFN-gamma, on ICAM-1 RNA levels is transcriptional. Colforsin 18-27 intercellular adhesion molecule 1 Rattus norvegicus 68-74 10379893-5 1999 Forskolin-stimulated cholesterol side chain cleavage enzyme (CYP11A) and 17alpha-hydroxylase/17,20-desmolase (CYP17) expression were augmented in PCOS theca cells compared with normal cells, whereas no differences were found in steroidogenic acute regulatory protein mRNA expression. Colforsin 0-9 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 61-67 10379893-5 1999 Forskolin-stimulated cholesterol side chain cleavage enzyme (CYP11A) and 17alpha-hydroxylase/17,20-desmolase (CYP17) expression were augmented in PCOS theca cells compared with normal cells, whereas no differences were found in steroidogenic acute regulatory protein mRNA expression. Colforsin 0-9 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 110-115 11230799-5 1999 Stimulation of cells with Ang II blocked the generation of cyclic adenosine monophosphate (cAMP), which follows the stimulation of hepatocytes with forskolin. Colforsin 148-157 angiotensinogen Rattus norvegicus 26-32 10411124-8 1999 TSH or forskolin, in contrast, halved the activity of the full length chimera within 24 hours and significantly suppressed the TNF-alpha and IFN-gamma-induced increase (>50%; p < 0.02). Colforsin 7-16 tumor necrosis factor Rattus norvegicus 127-136 10411124-8 1999 TSH or forskolin, in contrast, halved the activity of the full length chimera within 24 hours and significantly suppressed the TNF-alpha and IFN-gamma-induced increase (>50%; p < 0.02). Colforsin 7-16 interferon gamma Rattus norvegicus 141-150 10320759-0 1999 Forskolin-induced expression of tyrosine hydroxylase in human foetal brain cortex. Colforsin 0-9 tyrosine hydroxylase Homo sapiens 32-52 10320759-2 1999 In the present study this induction by BDNF/DA was found to be greatly amplified by adding forskolin (fsk: 10 microM) to the rat and human cerebral cortex cultures together with DA (10 microM) and BDNF (50 ng/ml). Colforsin 91-100 brain-derived neurotrophic factor Rattus norvegicus 39-43 10226075-1 1999 We demonstrated previously that in bovine tracheal myocytes, pretreatment with either forskolin or histamine significantly reduces both platelet-derived growth factor (PDGF)- and epidermal growth factor- induced Raf-1 activation but fails to inhibit extracellular signal-regulated kinase (ERK) activation substantially, evidence of a Raf-1-independent ERK activation pathway. Colforsin 86-95 RAF1 Bos taurus 212-217 10224047-9 1999 We now show that addition of a synthetic peptide corresponding to the entire third intracellular loop (3i) of the LH/CG R completely and specifically reverses desensitization of AC activity, with an ED50 of 10 microM but does not modulate basal, hCG-stimulated, or forskolin-stimulated AC activities. Colforsin 265-274 luteinizing hormone/choriogonadotropin receptor Homo sapiens 114-121 10340745-1 1999 Our previous studies have shown that transcription of brain creatine kinase (CKB) mRNA in U87-MG glioblastoma cells is stimulated by a forskolin-mediated increase in cyclic AMP (cAMP) via a pathway involving protein kinase A (PKA) and the activation of Galphas proteins. Colforsin 135-144 creatine kinase B Rattus norvegicus 54-75 10340745-1 1999 Our previous studies have shown that transcription of brain creatine kinase (CKB) mRNA in U87-MG glioblastoma cells is stimulated by a forskolin-mediated increase in cyclic AMP (cAMP) via a pathway involving protein kinase A (PKA) and the activation of Galphas proteins. Colforsin 135-144 creatine kinase B Homo sapiens 77-80 10226075-1 1999 We demonstrated previously that in bovine tracheal myocytes, pretreatment with either forskolin or histamine significantly reduces both platelet-derived growth factor (PDGF)- and epidermal growth factor- induced Raf-1 activation but fails to inhibit extracellular signal-regulated kinase (ERK) activation substantially, evidence of a Raf-1-independent ERK activation pathway. Colforsin 86-95 RAF1 Bos taurus 334-339 10320562-9 1999 Prolonged pretreatment of the cells with TGF-beta1(4 days) did not modify GH or TSH secretion nor dopamine-induced inhibition of prolactin secretion, and blunted prolactin responses to TRH, Forskolin, But2-cAMP and to the calcium ionophore A23187. Colforsin 190-199 transforming growth factor, beta 1 Rattus norvegicus 41-50 10385254-5 1999 PGE2, forskolin and db-cAMP suppressed IL-5 production by human T cell line following T cell receptor (TCR)-stimulation. Colforsin 6-15 interleukin 5 Homo sapiens 39-43 10385254-5 1999 PGE2, forskolin and db-cAMP suppressed IL-5 production by human T cell line following T cell receptor (TCR)-stimulation. Colforsin 6-15 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 86-101 10385254-5 1999 PGE2, forskolin and db-cAMP suppressed IL-5 production by human T cell line following T cell receptor (TCR)-stimulation. Colforsin 6-15 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 103-106 10218961-8 1999 cAMP elevating agents, forskolin and LH, suppressed ETA receptor mRNA expression in luteinized theca cells (LTC). Colforsin 23-32 endothelin receptor type A Bos taurus 52-55 10218961-11 1999 In both LGC and LTC there was an inverse relationship between ETA receptor gene expression and progesterone production; insulin (in LGC) and forskolin (in LTC) enhanced progesterone production while inhibiting ETA receptor mRNA levels. Colforsin 141-150 endothelin receptor type A Bos taurus 210-213 10217258-4 1999 After depolarization, Syt IV increases rapidly, peaks at 4 h, and decays to near baseline levels by 12 h. Forskolin stimulation also leads to rapid Syt IV protein accumulation. Colforsin 106-115 synaptotagmin 4 Rattus norvegicus 22-28 10217258-4 1999 After depolarization, Syt IV increases rapidly, peaks at 4 h, and decays to near baseline levels by 12 h. Forskolin stimulation also leads to rapid Syt IV protein accumulation. Colforsin 106-115 synaptotagmin 4 Rattus norvegicus 148-154 10217258-5 1999 The rate of Syt IV protein synthesis, determined by labeling with radioactive amino acids and immunoprecipitation, is low in unstimulated PC12 cells, but increases over the first 3 h after forskolin stimulation and remains elevated for several hours. Colforsin 189-198 synaptotagmin 4 Rattus norvegicus 12-18 10217258-8 1999 Vesicles immunoisolated from forskolin-treated PC12 cells with anti-Syt I antibody contain radioactively labeled Syt IV, demonstrating that Syt I and Syt IV colocalize in common vesicles. Colforsin 29-38 synaptotagmin 1 Rattus norvegicus 68-73 10217258-8 1999 Vesicles immunoisolated from forskolin-treated PC12 cells with anti-Syt I antibody contain radioactively labeled Syt IV, demonstrating that Syt I and Syt IV colocalize in common vesicles. Colforsin 29-38 synaptotagmin 4 Rattus norvegicus 113-119 10217258-8 1999 Vesicles immunoisolated from forskolin-treated PC12 cells with anti-Syt I antibody contain radioactively labeled Syt IV, demonstrating that Syt I and Syt IV colocalize in common vesicles. Colforsin 29-38 synaptotagmin 1 Rattus norvegicus 113-118 10217258-8 1999 Vesicles immunoisolated from forskolin-treated PC12 cells with anti-Syt I antibody contain radioactively labeled Syt IV, demonstrating that Syt I and Syt IV colocalize in common vesicles. Colforsin 29-38 synaptotagmin 4 Rattus norvegicus 150-156 10369484-4 1999 An enhanced NPY response was uncovered if the tissue was pre-contracted with 0.1 microM U46619, and relaxed back to baseline with 1-2 microM forskolin before the addition of NPY (49.8+/-5.3%, n = 14). Colforsin 141-150 neuropeptide Y Homo sapiens 12-15 10369484-5 1999 Forskolin (1 microM) stimulated cyclic AMP accumulation in porcine ear artery segments in the presence of 0.1 microM U46619 and 1 mM isobutylmethylxanthine (IBMX), NPY (0.1 microM) inhibited this response by 40%, but had no effect on basal levels of cyclic AMP. Colforsin 0-9 neuropeptide Y Homo sapiens 164-167 10320526-2 1999 Treatment of MC3T3-E1 cells with PTH(1-34) (10-8M) or forskolin (FSK; 10-5M) transiently increased a 7 kb FGF-2 transcript with a peak at 2 h. The PTH increase in FGF-2 mRNA was maintained in the presence of cycloheximide. Colforsin 54-63 fibroblast growth factor 2 Mus musculus 106-111 10320526-2 1999 Treatment of MC3T3-E1 cells with PTH(1-34) (10-8M) or forskolin (FSK; 10-5M) transiently increased a 7 kb FGF-2 transcript with a peak at 2 h. The PTH increase in FGF-2 mRNA was maintained in the presence of cycloheximide. Colforsin 54-63 fibroblast growth factor 2 Mus musculus 163-168 10320526-2 1999 Treatment of MC3T3-E1 cells with PTH(1-34) (10-8M) or forskolin (FSK; 10-5M) transiently increased a 7 kb FGF-2 transcript with a peak at 2 h. The PTH increase in FGF-2 mRNA was maintained in the presence of cycloheximide. Colforsin 65-68 fibroblast growth factor 2 Mus musculus 106-111 10320526-2 1999 Treatment of MC3T3-E1 cells with PTH(1-34) (10-8M) or forskolin (FSK; 10-5M) transiently increased a 7 kb FGF-2 transcript with a peak at 2 h. The PTH increase in FGF-2 mRNA was maintained in the presence of cycloheximide. Colforsin 65-68 fibroblast growth factor 2 Mus musculus 163-168 10320526-4 1999 In cells transiently transfected with an 1800-bp FGF-2 promoter-luciferase reporter, PTH and FSK increased luciferase activity at 2 h and 4 h. Immunohistochemistry showed that PTH and FSK increased FGF-2 protein labeling in the nuclei of MC3T3-E1 cells. Colforsin 93-96 fibroblast growth factor 2 Mus musculus 49-54 10320526-4 1999 In cells transiently transfected with an 1800-bp FGF-2 promoter-luciferase reporter, PTH and FSK increased luciferase activity at 2 h and 4 h. Immunohistochemistry showed that PTH and FSK increased FGF-2 protein labeling in the nuclei of MC3T3-E1 cells. Colforsin 93-96 fibroblast growth factor 2 Mus musculus 198-203 10320526-4 1999 In cells transiently transfected with an 1800-bp FGF-2 promoter-luciferase reporter, PTH and FSK increased luciferase activity at 2 h and 4 h. Immunohistochemistry showed that PTH and FSK increased FGF-2 protein labeling in the nuclei of MC3T3-E1 cells. Colforsin 184-187 fibroblast growth factor 2 Mus musculus 49-54 10217303-0 1999 Stimulation of adenylyl cyclase and induction of brain-derived neurotrophic factor and TrkB mRNA by NKH477, a novel and potent forskolin derivative. Colforsin 127-136 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 87-91 10320562-12 1999 The short-term TGF-beta1 effect did not modify Erk-2 phosphorylation, basal or TRH-induced increase in intracellular calcium concentration, but blunted basal and forskolin stimulated cAMP levels. Colforsin 162-171 transforming growth factor, beta 1 Rattus norvegicus 15-24 10319317-5 1999 Binding of CREB to a fragment of the hCRH promoter containing a canonical, functional cAMP response element was absent in untreated cells, but was specifically induced after activation of the protein kinase A pathway with forskolin. Colforsin 222-231 cAMP responsive element binding protein 1 Homo sapiens 11-15 10319317-5 1999 Binding of CREB to a fragment of the hCRH promoter containing a canonical, functional cAMP response element was absent in untreated cells, but was specifically induced after activation of the protein kinase A pathway with forskolin. Colforsin 222-231 corticotropin releasing hormone Homo sapiens 37-41 10411298-6 1999 In contrast, LH-, 8Br-cAMP and forskolin-stimulated progesterone production was inhibited by TNF alpha. Colforsin 31-40 tumor necrosis factor Mus musculus 93-102 10588574-6 1999 This seemed to be a direct effect because H2O2 also inhibited CREB phosphorylation induced by the adenylyl cyclase stimulator forskolin. Colforsin 126-135 cAMP responsive element binding protein 1 Rattus norvegicus 62-66 10420436-6 1999 A low concentration (10(-9) M) antagonizes melatonin inhibition of forskolin stimulation of cyclic AMP in NIH3T3 cells expressing human MT2 receptors, but has no effect in cells expressing mt1 receptors. Colforsin 67-76 metallothionein 2A Homo sapiens 136-139 10334508-9 1999 We conclude that adrenomedullin, forskolin and dbcAMP cause an increase in hyaluronic acid release in rat mesangial cells through a pathway that involves activation of wortmannin-sensitive kinase and P38 MAPK. Colforsin 33-42 mitogen activated protein kinase 14 Rattus norvegicus 200-208 10187789-6 1999 In intact PC12 cells, activation of PKA with forskolin resulted in a rapid inhibition of both CaMKK and CaMKI activity. Colforsin 45-54 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 36-39 10187833-5 1999 In these studies we confirmed that H7, but not HA1004, potently blocks the induction of zif268 and c-fos mRNA by nerve growth factor, carbachol, phorbol ester, Ca2+ ionophore, or forskolin. Colforsin 179-188 early growth response 1 Rattus norvegicus 88-94 10187789-6 1999 In intact PC12 cells, activation of PKA with forskolin resulted in a rapid inhibition of both CaMKK and CaMKI activity. Colforsin 45-54 calcium/calmodulin-dependent protein kinase I Rattus norvegicus 104-109 10365684-7 1999 The presence of cyclic adenosine monophosphate (cAMP)-generating system (forskolin) in TSH-free medium increased MMI-mediated TPO activity. Colforsin 73-82 thyroid peroxidase Homo sapiens 126-129 11225728-5 1999 Furthermore, the formation of this complex of p85alpha and phospho-IRS-1 was abolished by the presence of BAPTA-AM but not forskolin. Colforsin 123-132 insulin receptor substrate 1 Cricetulus griseus 67-72 10090941-4 1999 Inhibition of JAK3 may be controlled by intracellular cyclic adenosine monophosphate (cAMP) levels, as forskolin, a direct activator of adenylate cyclase and dibutyryl cAMP (dbcAMP), a membrane permeable analogue of cAMP suppressed JAK3 expression. Colforsin 103-112 Janus kinase 3 Homo sapiens 14-18 10090941-4 1999 Inhibition of JAK3 may be controlled by intracellular cyclic adenosine monophosphate (cAMP) levels, as forskolin, a direct activator of adenylate cyclase and dibutyryl cAMP (dbcAMP), a membrane permeable analogue of cAMP suppressed JAK3 expression. Colforsin 103-112 Janus kinase 3 Homo sapiens 232-236 10217400-4 1999 Mutation of the E-box enhanced the activation by c-Jun/c-Fos, as well as stimulation by forskolin and bFGF, that acts through the CRE/TRE site. Colforsin 88-97 tRNA-Glu (anticodon TTC) 3-1 Homo sapiens 134-137 10098509-8 1999 The stimulation of JNK by TSH was blocked by two PKC inhibitors and suppressed by 8-bromo-cAMP or forskolin. Colforsin 98-107 mitogen-activated protein kinase 8 Homo sapiens 19-22 10098510-7 1999 Costimulation of progesterone production by forskolin and dexamethasone was also inhibited by leptin, whereas the forskolin-induced cAMP production was not affected. Colforsin 44-53 leptin Rattus norvegicus 94-100 10102708-6 1999 Concomitant addition of insulin (10(-8) mol/l) to forskolin (5 x 10(-5) mol/l) reversed the decrease in PAI-1 antigen caused by forskolin alone. Colforsin 50-59 serpin family E member 1 Homo sapiens 104-109 10102708-6 1999 Concomitant addition of insulin (10(-8) mol/l) to forskolin (5 x 10(-5) mol/l) reversed the decrease in PAI-1 antigen caused by forskolin alone. Colforsin 128-137 insulin Homo sapiens 24-31 10102708-6 1999 Concomitant addition of insulin (10(-8) mol/l) to forskolin (5 x 10(-5) mol/l) reversed the decrease in PAI-1 antigen caused by forskolin alone. Colforsin 128-137 serpin family E member 1 Homo sapiens 104-109 10229085-5 1999 Stabilized cAMP or increasing the cAMP level by forskolin enhanced fibronectin synthesis with similar kinetics. Colforsin 48-57 fibronectin 1 Homo sapiens 67-78 10464778-12 1999 Experiments on the cultured cells transfected with the nociceptin receptor cDNA showed that NalBzoH competed in [3H]-nociceptin binding and attenuated the nociceptin-induced inhibition of cyclic AMP accumulation induced by forskolin. Colforsin 223-232 opioid receptor-like 1 Mus musculus 55-74 10230790-4 1999 Phox2 proteins are, moreover, necessary for the induction of both TH and DBH by bone morphogenetic protein 2 (BMP2) (which induces Phox2a/b) and forskolin. Colforsin 145-154 tyrosine hydroxylase Homo sapiens 66-68 10230790-4 1999 Phox2 proteins are, moreover, necessary for the induction of both TH and DBH by bone morphogenetic protein 2 (BMP2) (which induces Phox2a/b) and forskolin. Colforsin 145-154 dopamine beta-hydroxylase Homo sapiens 73-76 10230790-4 1999 Phox2 proteins are, moreover, necessary for the induction of both TH and DBH by bone morphogenetic protein 2 (BMP2) (which induces Phox2a/b) and forskolin. Colforsin 145-154 bone morphogenetic protein 2 Homo sapiens 110-114 10070131-4 1999 Jejunal segments from anti-CD3-treated mice displayed a significantly elevated epithelial baseline short-circuit current (which indicates increased ion transport) and a concomitant reduction in responsiveness to prosecretory stimuli (nerve stimulation, carbachol, and forskolin). Colforsin 268-277 CD3 antigen, epsilon polypeptide Mus musculus 27-30 10203138-4 1999 Carbachol and BrcAMP or BrcAMP and forskolin, given in combination, produced additive effects on enzyme secretion in the Cftr+/+ acini. Colforsin 35-44 cystic fibrosis transmembrane conductance regulator Mus musculus 121-125 10037721-3 1999 Treatment of bovine carotid artery smooth muscles with the phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine, and the adenylate cyclase activator, forskolin, led to increases in the phosphorylation of HSP20 and dissociation of macromolecular aggregates of HSP20. Colforsin 154-163 heat shock protein beta-6 Bos taurus 208-213 10037721-3 1999 Treatment of bovine carotid artery smooth muscles with the phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine, and the adenylate cyclase activator, forskolin, led to increases in the phosphorylation of HSP20 and dissociation of macromolecular aggregates of HSP20. Colforsin 154-163 heat shock protein beta-6 Bos taurus 263-268 10203138-3 1999 BrcAMP and forskolin alone induced higher amylase secretion (% initial amylase content) in the Cftr+/+ acini than carbachol (p < 0.05). Colforsin 11-20 cystic fibrosis transmembrane conductance regulator Mus musculus 95-99 10075669-3 1999 Activation of PKA by forskolin resulted in elevated expression of the PSA gene in androgen-depleted LNCaP cells, an effect that was blocked by the antiandrogen, bicalutamide. Colforsin 21-30 kallikrein related peptidase 3 Homo sapiens 70-73 10075669-6 1999 In addition, when nuclear AR from forskolin-treated LNCaP cells was incubated with oligonucleotides encoding an androgen response element of the PSA promoter and examined by electromobility shift assay, an increase in AR-androgen response element complex formation was observed. Colforsin 34-43 androgen receptor Homo sapiens 26-28 10075669-6 1999 In addition, when nuclear AR from forskolin-treated LNCaP cells was incubated with oligonucleotides encoding an androgen response element of the PSA promoter and examined by electromobility shift assay, an increase in AR-androgen response element complex formation was observed. Colforsin 34-43 kallikrein related peptidase 3 Homo sapiens 145-148 10075669-6 1999 In addition, when nuclear AR from forskolin-treated LNCaP cells was incubated with oligonucleotides encoding an androgen response element of the PSA promoter and examined by electromobility shift assay, an increase in AR-androgen response element complex formation was observed. Colforsin 34-43 androgen receptor Homo sapiens 218-220 10066362-7 1999 Forskolin and pentoxifylline, two other agents known to elevate intracellular cyclic AMP through different mechanisms, also potently decreased Id4 gene expression. Colforsin 0-9 inhibitor of DNA binding 4 Mus musculus 143-146 10026109-4 1999 This was probably a result of a synergistic interaction between forskolin and insulin, observed on both StAR and P450scc mRNA levels. Colforsin 64-73 steroidogenic acute regulatory protein Bos taurus 104-108 10026109-4 1999 This was probably a result of a synergistic interaction between forskolin and insulin, observed on both StAR and P450scc mRNA levels. Colforsin 64-73 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 113-120 10026109-5 1999 However, in luteinized granulosa cells (LGC), forskolin and insulin each independently were able to up-regulate the levels of P450scc and StAR mRNA levels, respectively. Colforsin 46-55 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 126-133 10026109-5 1999 However, in luteinized granulosa cells (LGC), forskolin and insulin each independently were able to up-regulate the levels of P450scc and StAR mRNA levels, respectively. Colforsin 46-55 steroidogenic acute regulatory protein Bos taurus 138-142 10067864-7 1999 The effect of TSH on [125I]ANF binding was mimicked by forskolin and (Bu)2cAMP, indicating receptor up-regulation via a cAMP pathway. Colforsin 55-64 natriuretic peptide A Rattus norvegicus 27-30 10192430-6 1999 INF increased IGFBP4 mRNA and protein levels at 12 h, with a decline to baseline by 24 h. In contrast, IGFBP4 was not regulated in response to IL-6, TNF-alpha, PDGF BB, bFGF, TGF-beta or the cAMP agonist, forskolin. Colforsin 205-214 interferon gamma Homo sapiens 0-3 10205014-18 1999 This suggestion is supported by the finding that GR128107, like melatonin, acted as a full agonist and inhibited forskolin-stimulation of cyclic AMP accumulation in NIH-3T3 cells expressing a high density of human mt1 or MT2 receptors. Colforsin 113-122 metallothionein 1I, pseudogene Homo sapiens 214-217 10205014-18 1999 This suggestion is supported by the finding that GR128107, like melatonin, acted as a full agonist and inhibited forskolin-stimulation of cyclic AMP accumulation in NIH-3T3 cells expressing a high density of human mt1 or MT2 receptors. Colforsin 113-122 metallothionein 2A Homo sapiens 221-224 10067849-7 1999 In addition, treatment with GDF-9, like forskolin, also stimulated inhibin-alpha content in explants of neonatal ovaries. Colforsin 40-49 growth differentiation factor 9 Rattus norvegicus 28-33 10024343-10 1999 Third, we increased the size of exo/endo cycling vesicle pool by forskolin, which enhances synaptic transmission. Colforsin 65-74 phantom Drosophila melanogaster 32-35 10082506-6 1999 Experiments with both actinomycin D and 5, 6-dichlororibofuranosylbenzimidazole (DRB) showed that forskolin treatment markedly stabilized hREN mRNA in Calu-6 cells. Colforsin 98-107 renin Homo sapiens 138-142 10082506-8 1999 Experiments with DRB demonstrated a similar robust stabilization of hREN mRNA after forskolin and phorbol ester treatment. Colforsin 84-93 renin Homo sapiens 68-72 10024343-11 1999 The forskolin treatment increased both the size of exo/endo cycling vesicle pool and the quantal content. Colforsin 4-13 phantom Drosophila melanogaster 51-54 10100738-2 1999 During forskolin (Fsk) stimulation, melatonin reduced the amplitude of the CFTR currents in oocytes injected with in vitro transcribed cRNAs for the Xenopus melatonin receptor and CFTR. Colforsin 7-16 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 75-79 10100738-2 1999 During forskolin (Fsk) stimulation, melatonin reduced the amplitude of the CFTR currents in oocytes injected with in vitro transcribed cRNAs for the Xenopus melatonin receptor and CFTR. Colforsin 18-21 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 75-79 10100738-2 1999 During forskolin (Fsk) stimulation, melatonin reduced the amplitude of the CFTR currents in oocytes injected with in vitro transcribed cRNAs for the Xenopus melatonin receptor and CFTR. Colforsin 18-21 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 180-184 10100738-3 1999 Pertussis toxin (Ptx) treatment eliminated melatonin inhibition of Fsk stimulated CFTR currents. Colforsin 67-70 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 82-86 10026223-6 1999 H-89 blocks ERK activation by forskolin, but weakly affects the response to NECA or UTP. Colforsin 30-39 mitogen-activated protein kinase 1 Homo sapiens 12-15 10077003-2 1999 We have examined the effect of basic fibroblast factor (bFGF) and forskolin on CCK gene transcription and depicted the signaling pathways that lead to promoter activation. Colforsin 66-75 cholecystokinin Homo sapiens 79-82 10026223-9 1999 In the presence of forskolin, Ro 31-8220 loses its ability to block UTP-stimulated ERK activation. Colforsin 19-28 mitogen-activated protein kinase 1 Homo sapiens 83-86 10077003-8 1999 Forskolin stimulation proceeded via the PKA pathway, and to a minor extent via the p38 and ERK MAPK pathways. Colforsin 0-9 mitogen-activated protein kinase 14 Homo sapiens 83-86 10077003-8 1999 Forskolin stimulation proceeded via the PKA pathway, and to a minor extent via the p38 and ERK MAPK pathways. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 91-94 10077003-8 1999 Forskolin stimulation proceeded via the PKA pathway, and to a minor extent via the p38 and ERK MAPK pathways. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 95-99 10077003-9 1999 We conclude that bFGF and forskolin stimulate the CCK gene promoter via the CRE/TRE(-80) in the proximal promoter region. Colforsin 26-35 cholecystokinin Homo sapiens 50-53 10077006-2 1999 Treatment of confluent monolayers either with forskolin or cAMP produced a 60- to 75-fold induction of IGFBP-3 mRNA and protein levels. Colforsin 46-55 insulin like growth factor binding protein 3 Bos taurus 103-110 9988736-3 1999 In nonstimulated IMCD cells the majority of AQP-2 staining was detected intracellularly but became mainly localized within the cell membrane after stimulation with AVP or forskolin. Colforsin 171-180 aquaporin 2 Rattus norvegicus 44-49 9988736-4 1999 Quantitative analysis revealed that preincubation of the cells with the synthetic peptide S-Ht31, which prevents the binding between AKAPs and regulatory subunits of PKA, strongly inhibited AQP-2 translocation in response to forskolin. Colforsin 225-234 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 166-169 9988736-4 1999 Quantitative analysis revealed that preincubation of the cells with the synthetic peptide S-Ht31, which prevents the binding between AKAPs and regulatory subunits of PKA, strongly inhibited AQP-2 translocation in response to forskolin. Colforsin 225-234 aquaporin 2 Rattus norvegicus 190-195 9988736-5 1999 Preincubation of the cells with the PKA inhibitor H89 prior to forskolin stimulation abolished AQP-2 translocation. Colforsin 63-72 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 36-39 9988736-5 1999 Preincubation of the cells with the PKA inhibitor H89 prior to forskolin stimulation abolished AQP-2 translocation. Colforsin 63-72 aquaporin 2 Rattus norvegicus 95-100 10082211-4 1999 In addition, the potencies and efficacies of pergolide and bromocriptine, as well as that of dopamine, at the dopamine D1 receptor were increased in the presence of forskolin, an adenylate cyclase activator. Colforsin 165-174 dopamine receptor D1 Homo sapiens 110-130 9933023-8 1999 Adenosine deaminase (ADA, EC 3.5.44, 1 U/mL) reduced the intracellular cyclic AMP response to forskolin by 68%, whereas the adenosine transport inhibitor, dipyridamole (10 microM), significantly increased 1 and 10 microM forskolin-dependent cyclic AMP accumulation. Colforsin 94-103 adenosine deaminase Rattus norvegicus 0-19 9933023-8 1999 Adenosine deaminase (ADA, EC 3.5.44, 1 U/mL) reduced the intracellular cyclic AMP response to forskolin by 68%, whereas the adenosine transport inhibitor, dipyridamole (10 microM), significantly increased 1 and 10 microM forskolin-dependent cyclic AMP accumulation. Colforsin 94-103 adenosine deaminase Rattus norvegicus 21-24 9933023-8 1999 Adenosine deaminase (ADA, EC 3.5.44, 1 U/mL) reduced the intracellular cyclic AMP response to forskolin by 68%, whereas the adenosine transport inhibitor, dipyridamole (10 microM), significantly increased 1 and 10 microM forskolin-dependent cyclic AMP accumulation. Colforsin 221-230 adenosine deaminase Rattus norvegicus 0-19 9933023-8 1999 Adenosine deaminase (ADA, EC 3.5.44, 1 U/mL) reduced the intracellular cyclic AMP response to forskolin by 68%, whereas the adenosine transport inhibitor, dipyridamole (10 microM), significantly increased 1 and 10 microM forskolin-dependent cyclic AMP accumulation. Colforsin 221-230 adenosine deaminase Rattus norvegicus 21-24 10082650-6 1999 Only SF-35 and SF-98 seem to play a major role in the cAMP-induced regulation of the hACTH-R gene, since mutation of either one of these sites reduced the forskolin induction of luciferase activity by 50%. Colforsin 155-164 melanocortin 2 receptor Homo sapiens 85-92 9922228-0 1999 Forskolin inhibits cyclin D1 expression in cultured airway smooth-muscle cells. Colforsin 0-9 cyclin D1 Bos taurus 19-28 9922228-8 1999 In addition, forskolin pretreatment decreased both cyclin D1 promoter activity and protein levels. Colforsin 13-22 cyclin D1 Bos taurus 51-60 9922228-9 1999 Forskolin treatment induced the phosphorylation of CREB and increased the binding of nuclear protein to the cyclin D1 promoter CRE. Colforsin 0-9 cAMP responsive element binding protein 1 Bos taurus 51-55 9922228-9 1999 Forskolin treatment induced the phosphorylation of CREB and increased the binding of nuclear protein to the cyclin D1 promoter CRE. Colforsin 0-9 cyclin D1 Bos taurus 108-117 9927320-6 1999 Similarly, the combination of IL-1beta and the diterpene forskolin (but not the inactive analog 1,9-dideoxyforskolin) or cholera toxin also resulted in a synergistic stimulation of C6 glioma IL-6 release. Colforsin 57-66 interleukin 6 Rattus norvegicus 191-195 10188977-3 1999 In CB2-transfected cells, L759633 and L759656 were potent inhibitors of forskolin-stimulated cyclic AMP production, with EC50 values of 8.1 and 3.1 nM respectively and CB1/CB2 EC50 ratios of > 1000 and > 3000 respectively. Colforsin 72-81 cannabinoid receptor 2 Homo sapiens 3-6 10188977-3 1999 In CB2-transfected cells, L759633 and L759656 were potent inhibitors of forskolin-stimulated cyclic AMP production, with EC50 values of 8.1 and 3.1 nM respectively and CB1/CB2 EC50 ratios of > 1000 and > 3000 respectively. Colforsin 72-81 cannabinoid receptor 1 Homo sapiens 168-171 10188977-3 1999 In CB2-transfected cells, L759633 and L759656 were potent inhibitors of forskolin-stimulated cyclic AMP production, with EC50 values of 8.1 and 3.1 nM respectively and CB1/CB2 EC50 ratios of > 1000 and > 3000 respectively. Colforsin 72-81 cannabinoid receptor 2 Homo sapiens 172-175 10188977-4 1999 AM630 inhibited [35S]-GTPgammaS binding to CB2 receptor membranes (EC50 = 76.6 nM), enhanced forskolin-stimulated cyclic AMP production in CB2-transfected cells (5.2 fold by 1 microM), and antagonized the inhibition of forskolin-stimulated cyclic AMP production in this cell line induced by CP55940. Colforsin 93-102 cannabinoid receptor 2 Homo sapiens 139-142 10188977-5 1999 In CB1-transfected cells, forskolin-stimulated cyclic AMP production was significantly inhibited by AM630 (22.6% at 1 microM and 45.9% at 10 microM) and by L759633 at 10 microM (48%) but not 1 microM. Colforsin 26-35 cannabinoid receptor 1 Homo sapiens 3-6 10065344-12 1999 The component of whole-cell Kv current affected by PGI2 may be due to slowly inactivating, 4-AP-sensitive, 15 pS delayed-rectifier K+ channels (KDR); the activity of these channels in vascular myocytes is increased by forskolin and protein kinase A (PKA) and rabbit portal vein Kv1.5 pore-forming alpha-subunits, which appear to be a component of native KDR current and possess consensus phosphorylation sequences for PKA. Colforsin 218-227 vascular endothelial growth factor receptor 2 Oryctolagus cuniculus 144-147 10027771-10 1999 Finally, NPY significantly inhibited the forskolin-induced cAMP production in smooth muscle but not in endothelial cell cultures. Colforsin 41-50 neuropeptide Y Homo sapiens 9-12 9922315-6 1999 Forskolin mimicked the stimulatory effects of these neurotransmitters on IL-6 secretion, and the protein kinase inhibitor6-22 amide abolished the actions of VIP, CGRP, and norepinephrine, but not that of human recombinant IL-1beta, on IL-6 secretion. Colforsin 0-9 interleukin 6 Homo sapiens 73-77 9950956-8 1999 This effect on AQP2 phosphorylation was mimicked by the vasopressin (V2) agonist, 1-desamino-[8-D-arginine]vasopressin (DDAVP), or forskolin. Colforsin 131-140 aquaporin 2 Rattus norvegicus 15-19 9950956-9 1999 Two-dimensional phosphopeptide mapping indicated that AVP and forskolin stimulated the phosphorylation of the same site in AQP2. Colforsin 62-71 aquaporin 2 Rattus norvegicus 123-127 9878848-3 1999 We investigated proliferation and differentiation of twi/twi Schwann cells in response to forskolin, an adenylate cyclase activator. Colforsin 90-99 galactosylceramidase Mus musculus 53-56 9930728-12 1999 The adenylyl cyclase activator forskolin and the cAMP analogue dibutyryl cAMP also reduced IL-1beta production. Colforsin 31-40 interleukin 1 beta Rattus norvegicus 91-99 10213069-9 1999 A limited increase in VDR mRNA levels was observed in the cells treated with 1,25(OH)2D3, fetal bovine serum or forskolin. Colforsin 112-121 vitamin D receptor Homo sapiens 22-25 9878848-3 1999 We investigated proliferation and differentiation of twi/twi Schwann cells in response to forskolin, an adenylate cyclase activator. Colforsin 90-99 galactosylceramidase Mus musculus 57-60 9878848-4 1999 In twi/twi Schwann cells isolated at the postnatal day (P) 10 prior to the onset of demyelination, proliferation and an expression of the surface galactocerebroside (galC) in response to forskolin were similar to those of +/+ mice. Colforsin 187-196 galactosylceramidase Mus musculus 3-6 9878848-4 1999 In twi/twi Schwann cells isolated at the postnatal day (P) 10 prior to the onset of demyelination, proliferation and an expression of the surface galactocerebroside (galC) in response to forskolin were similar to those of +/+ mice. Colforsin 187-196 galactosylceramidase Mus musculus 7-10 9878848-4 1999 In twi/twi Schwann cells isolated at the postnatal day (P) 10 prior to the onset of demyelination, proliferation and an expression of the surface galactocerebroside (galC) in response to forskolin were similar to those of +/+ mice. Colforsin 187-196 galactosylceramidase Mus musculus 166-170 9878848-7 1999 However, with an administration of 50 microM forskolin in the media containing 1% fetal bovine serum (FBS) on the 4 DIV, surface galC could be reexpressed in all +/+ and P10 twi/twi Schwann cells but not in P20 or P30 twi/twi cells. Colforsin 45-54 galactosylceramidase Mus musculus 129-133 9878848-7 1999 However, with an administration of 50 microM forskolin in the media containing 1% fetal bovine serum (FBS) on the 4 DIV, surface galC could be reexpressed in all +/+ and P10 twi/twi Schwann cells but not in P20 or P30 twi/twi cells. Colforsin 45-54 S100 calcium binding protein A10 (calpactin) Mus musculus 170-173 9878848-7 1999 However, with an administration of 50 microM forskolin in the media containing 1% fetal bovine serum (FBS) on the 4 DIV, surface galC could be reexpressed in all +/+ and P10 twi/twi Schwann cells but not in P20 or P30 twi/twi cells. Colforsin 45-54 galactosylceramidase Mus musculus 174-177 9878848-7 1999 However, with an administration of 50 microM forskolin in the media containing 1% fetal bovine serum (FBS) on the 4 DIV, surface galC could be reexpressed in all +/+ and P10 twi/twi Schwann cells but not in P20 or P30 twi/twi cells. Colforsin 45-54 galactosylceramidase Mus musculus 178-181 9878848-7 1999 However, with an administration of 50 microM forskolin in the media containing 1% fetal bovine serum (FBS) on the 4 DIV, surface galC could be reexpressed in all +/+ and P10 twi/twi Schwann cells but not in P20 or P30 twi/twi cells. Colforsin 45-54 demilune cell and parotid protein 1 Mus musculus 207-210 9878719-4 1999 5-HT and the 5-HT1A receptor agonist, (+)8-hydroxy-2(di-N-propylamino)tetraline (8-OH-DPAT), were able to inhibit forskolin-stimulated adenylyl cyclase activity in a dose-dependent manner for 48 h after death in rat and human brain. Colforsin 114-123 5-hydroxytryptamine receptor 1A Homo sapiens 13-28 10195701-5 1999 The promoter activity in VSMC was stimulated by TNF alpha and dexamethasone, and was suppressed by 8-bromo-cAMP and forskolin. Colforsin 116-125 tumor necrosis factor Rattus norvegicus 48-57 9878848-7 1999 However, with an administration of 50 microM forskolin in the media containing 1% fetal bovine serum (FBS) on the 4 DIV, surface galC could be reexpressed in all +/+ and P10 twi/twi Schwann cells but not in P20 or P30 twi/twi cells. Colforsin 45-54 high mobility group box 1 Mus musculus 214-217 9878848-7 1999 However, with an administration of 50 microM forskolin in the media containing 1% fetal bovine serum (FBS) on the 4 DIV, surface galC could be reexpressed in all +/+ and P10 twi/twi Schwann cells but not in P20 or P30 twi/twi cells. Colforsin 45-54 galactosylceramidase Mus musculus 178-181 9878848-7 1999 However, with an administration of 50 microM forskolin in the media containing 1% fetal bovine serum (FBS) on the 4 DIV, surface galC could be reexpressed in all +/+ and P10 twi/twi Schwann cells but not in P20 or P30 twi/twi cells. Colforsin 45-54 galactosylceramidase Mus musculus 178-181 9878848-8 1999 In the media containing 10% FBS, forskolin also stimulated proliferation of Schwann cells from P10 twi/twi, and P10 and P30+/+ mice but not those from P30 twi/twi mice. Colforsin 33-42 S100 calcium binding protein A10 (calpactin) Mus musculus 95-98 9878848-8 1999 In the media containing 10% FBS, forskolin also stimulated proliferation of Schwann cells from P10 twi/twi, and P10 and P30+/+ mice but not those from P30 twi/twi mice. Colforsin 33-42 galactosylceramidase Mus musculus 99-102 9878848-8 1999 In the media containing 10% FBS, forskolin also stimulated proliferation of Schwann cells from P10 twi/twi, and P10 and P30+/+ mice but not those from P30 twi/twi mice. Colforsin 33-42 galactosylceramidase Mus musculus 103-106 9878848-8 1999 In the media containing 10% FBS, forskolin also stimulated proliferation of Schwann cells from P10 twi/twi, and P10 and P30+/+ mice but not those from P30 twi/twi mice. Colforsin 33-42 S100 calcium binding protein A10 (calpactin) Mus musculus 112-115 9878848-8 1999 In the media containing 10% FBS, forskolin also stimulated proliferation of Schwann cells from P10 twi/twi, and P10 and P30+/+ mice but not those from P30 twi/twi mice. Colforsin 33-42 high mobility group box 1 Mus musculus 120-123 9878848-8 1999 In the media containing 10% FBS, forskolin also stimulated proliferation of Schwann cells from P10 twi/twi, and P10 and P30+/+ mice but not those from P30 twi/twi mice. Colforsin 33-42 galactosylceramidase Mus musculus 103-106 9878848-8 1999 In the media containing 10% FBS, forskolin also stimulated proliferation of Schwann cells from P10 twi/twi, and P10 and P30+/+ mice but not those from P30 twi/twi mice. Colforsin 33-42 galactosylceramidase Mus musculus 103-106 10077231-11 1999 Treatment of the cells with adrenaline and forskolin evoked a 3 fold increase in the activity of serotonin N-acetyltransferase with the peak occurring 6 h after stimulation. Colforsin 43-52 arylalkylamine N-acetyltransferase Mus musculus 97-126 9931442-8 1999 Nurr2 and Nurr1 were also concomitantly induced by forskolin in NIH3T3 cells. Colforsin 51-60 nuclear receptor subfamily 4, group A, member 2 Mus musculus 10-15 9887008-5 1999 Effects of VIP and PACAP-(1-38) were mimicked by forskolin (10(-7) to 10(-6) M) but not by 8-bromo-cGMP, whereas theophylline enhanced the effects of VIP. Colforsin 49-58 VIP peptides Oryctolagus cuniculus 11-14 9887008-5 1999 Effects of VIP and PACAP-(1-38) were mimicked by forskolin (10(-7) to 10(-6) M) but not by 8-bromo-cGMP, whereas theophylline enhanced the effects of VIP. Colforsin 49-58 LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide Oryctolagus cuniculus 19-24 10810514-12 1999 Intracellular mechanisms of the melatonin effect may involve cAMP, because melatonin inhibits the VIP-induced increase of cAMP and increase of cAMP formation by forskolin stimulates AVP release from the cultures. Colforsin 161-170 vasoactive intestinal peptide Rattus norvegicus 98-101 10025508-9 1999 In addition, the opioid agonist D-Pen2-D-Pen5-enkephalin inhibited forskolin-stimulated OFQ peptide secretion. Colforsin 67-76 presenilin enhancer gamma secretase subunit Mus musculus 34-38 9892211-3 1999 We have studied the effects of EGF, IGF-I, and the protein kinase A (PKA) activator forskolin on the activation of p42/ extracellular signal-regulated kinase (ERK)2, which is a key kinase in mediation of growth factor-induced mitogenesis in prostate cancer cells. Colforsin 84-93 cyclin dependent kinase 20 Homo sapiens 115-118 9892211-3 1999 We have studied the effects of EGF, IGF-I, and the protein kinase A (PKA) activator forskolin on the activation of p42/ extracellular signal-regulated kinase (ERK)2, which is a key kinase in mediation of growth factor-induced mitogenesis in prostate cancer cells. Colforsin 84-93 mitogen-activated protein kinase 1 Homo sapiens 120-164 9892211-5 1999 EGF, IGF-I, and forskolin-induced PKA activity stimulate intracellular signaling pathways converging at the level of p42/ERK2. Colforsin 16-25 cyclin dependent kinase 20 Homo sapiens 117-120 9892211-5 1999 EGF, IGF-I, and forskolin-induced PKA activity stimulate intracellular signaling pathways converging at the level of p42/ERK2. Colforsin 16-25 mitogen-activated protein kinase 1 Homo sapiens 121-125 9892211-9 1999 The effects of EGF on p42/ERK2 are potentiated by forskolin in both cell lines. Colforsin 50-59 epidermal growth factor Homo sapiens 15-18 9892211-9 1999 The effects of EGF on p42/ERK2 are potentiated by forskolin in both cell lines. Colforsin 50-59 cyclin dependent kinase 20 Homo sapiens 22-25 10449982-4 1999 Forskolin also stimulated cAMP and IGF-I (but not IGF-II) in both serum-containing and serum-free cultures. Colforsin 0-9 insulin-like growth factor 1 Mus musculus 35-40 9886493-9 1999 By continually treating Reh cells with forskolin for 72 h, we observed a sustained elevated expression of Mad1 concomitant with downregulated c-Myc expression, still without changing the differentiation profile of the Reh cells. Colforsin 39-48 MAX dimerization protein 1 Homo sapiens 106-110 9886832-8 1999 The expression of both CRF and CRF-BP is positively regulated by forskolin and interleukin-6. Colforsin 65-74 corticotropin releasing hormone binding protein Homo sapiens 31-37 9886493-8 1999 By coimmunoprecipitation we detected increased binding of Mad1 to Max in forskolin-treated cells, indicating that the changes in Mad1 protein levels had functional implications. Colforsin 73-82 MAX dimerization protein 1 Homo sapiens 58-62 9886493-8 1999 By coimmunoprecipitation we detected increased binding of Mad1 to Max in forskolin-treated cells, indicating that the changes in Mad1 protein levels had functional implications. Colforsin 73-82 MAX dimerization protein 1 Homo sapiens 129-133 9854186-4 1999 In both adrenocortical cell lines used, MVDP is constitutively synthesized and its accumulation is increased by treatment with cAMP or forskolin. Colforsin 135-144 aldo-keto reductase family 1, member B7 Mus musculus 40-44 9886493-7 1999 The Mad1 protein levels essentially paralleled those of mRNA, with peak levels at 4 h of forskolin treatment. Colforsin 89-98 MAX dimerization protein 1 Homo sapiens 4-8 9886493-9 1999 By continually treating Reh cells with forskolin for 72 h, we observed a sustained elevated expression of Mad1 concomitant with downregulated c-Myc expression, still without changing the differentiation profile of the Reh cells. Colforsin 39-48 MYC proto-oncogene, bHLH transcription factor Homo sapiens 142-147 9886493-11 1999 To this extent, following forskolin treatment of Reh cells, cyclin E-cdk2 activity was transiently reduced concomitant with dephosphorylation of pRB. Colforsin 26-35 RB transcriptional corepressor 1 Homo sapiens 145-148 10838433-9 1999 Of the compounds tested, only PTH, prostaglandin E(2), 8-bromo-cAMP, and forskolin induced c-fos mRNA levels, indicating that this assay was specific for compounds that are known to induce cAMP and stimulate bone growth. Colforsin 73-82 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 91-96 9854186-5 1999 MVDP mRNA steady-state levels were up-regulated by forskolin in adrenocortical cells by a process that does not require de novo protein synthesis. Colforsin 51-60 aldo-keto reductase family 1, member B7 Mus musculus 0-4 10462075-4 1999 We previously showed that a line of C6 rat glioma cells that expresses a GFAP-TH transgene, C6-THA, displays increased transgene activity when differentiated by forskolin treatment. Colforsin 161-170 glial fibrillary acidic protein Homo sapiens 73-77 10227591-3 1999 Treatment of RASMC and H9C2 cells with forskolin, an adenylyl cyclase stimulator, decreased caveolin-1 mRNA levels in a dose-dependent manner. Colforsin 39-48 caveolin 1 Rattus norvegicus 92-102 10227591-6 1999 The levels of caveolin-1 and -3 proteins were also decreased by forskolin treatment, but only after 60-72 hours in RASMC and 24-36 hours in H9C2 cells. Colforsin 64-73 caveolin 1 Rattus norvegicus 14-31 10462083-7 1999 Forskolin (0.1 to 3 microM), an activator of adenylyl cyclase, induced a concentration-dependent positive inotropism which was also inhibited by (R)p-cAMPS, actinomycin D and cycloheximide. Colforsin 0-9 calmodulin 2, pseudogene 1 Rattus norvegicus 150-155 10462083-10 1999 As it was inhibited by a protein kinase A inhibitor ((R)p-cAMPS) and similarly to isoproterenol, the positive inotropism induced by forskolin, which increases cytosolic cAMP, was also inhibited by actinomycin D and cycloheximide. Colforsin 132-141 calmodulin 2, pseudogene 1 Rattus norvegicus 58-63 9870951-5 1999 PACAP elicited increases of [Ca2+]i in 27% of the analyzed neurons, many of which were also responsive to the RHT neurotransmitters glutamate and/or substance P. PACAP-induced changes of [Ca2+]i were independent of cAMP, because they were not mimicked by forskolin or 8-bromo-cAMP. Colforsin 255-264 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 9870951-5 1999 PACAP elicited increases of [Ca2+]i in 27% of the analyzed neurons, many of which were also responsive to the RHT neurotransmitters glutamate and/or substance P. PACAP-induced changes of [Ca2+]i were independent of cAMP, because they were not mimicked by forskolin or 8-bromo-cAMP. Colforsin 255-264 adenylate cyclase activating polypeptide 1 Rattus norvegicus 162-167 10374908-4 1999 Glucagon and GLP-1 (10(-7) M) decreased by about 45-50% cyclic-AMP production by dispersed inner adrenocortical cells in response to ACTH (10(-9) M), but not to the adenylate cyclase activator forskolin (10(-5) M). Colforsin 193-202 glucagon Rattus norvegicus 13-18 9950152-3 1999 The expression of ERV-3 env mRNA increased after 48 h forskolin treatment, concurrently with increased intercellular fusion and production of human chorionic gonadotropin (beta-hCG) mRNA, a hormonal differentiation marker for trophoblast. Colforsin 54-63 endogenous retrovirus group 3 member 1, envelope Homo sapiens 18-23 10815617-13 1999 Similarly, forskolin (10, 50 or 100 microM) can also reverse the inhibition of PGE2 on increased COX activity in IL-1beta treated HUVEC. Colforsin 11-20 interleukin 1 beta Homo sapiens 113-121 10051190-0 1999 Masking of forskolin-induced long-term potentiation by adenosine accumulation in area CA1 of the rat hippocampus. Colforsin 11-20 carbonic anhydrase 1 Rattus norvegicus 86-89 10051190-3 1999 The present study was aimed at investigating whether forskolin, an adenylyl cyclase activator, could produce long-term effects at the Schaffer collateral-CA1 synapses using extracellular recording techniques. Colforsin 53-62 carbonic anhydrase 1 Rattus norvegicus 154-157 10051202-7 1999 In contrast, forskolin, another potent stimulator of adenylate cyclase besides PACAP, dramatically decreased [3H]thymidine incorporation. Colforsin 13-22 adenylate cyclase activating polypeptide 1 Rattus norvegicus 79-84 9880335-5 1999 Second, in polarized Madin-Darby canine kidney (MDCK) cells, which expressed human uPAR apically, the low basal rate of uPAR ligand endocytosis, which could not be inhibited by RAP, was increased by forskolin or phorbol ester (phorbol 12-myristate 13-acetate), which selectively up-regulate clathrin-independent endocytosis from the apical domain of epithelial cells. Colforsin 199-208 plasminogen activator, urokinase receptor Homo sapiens 83-87 9880335-5 1999 Second, in polarized Madin-Darby canine kidney (MDCK) cells, which expressed human uPAR apically, the low basal rate of uPAR ligand endocytosis, which could not be inhibited by RAP, was increased by forskolin or phorbol ester (phorbol 12-myristate 13-acetate), which selectively up-regulate clathrin-independent endocytosis from the apical domain of epithelial cells. Colforsin 199-208 plasminogen activator, urokinase receptor Homo sapiens 120-124 9892847-12 1999 The cAMP enhancers, caffeine, NaF and forskolin significantly increased the thymulin-stimulated release of GH while trifluoperazine, a protein kinase C inhibitor, had no effect. Colforsin 38-47 gonadotropin releasing hormone receptor Rattus norvegicus 107-109 10362304-0 1999 Forskolin and dopamine D1 receptor activation increase huntingtin"s association with endosomes in immortalized neuronal cells of striatal origin. Colforsin 0-9 huntingtin Homo sapiens 55-65 10362304-5 1999 When these neurons were differentiated by treatment with forskolin, huntingtin redistributed to perinuclear regions, discrete puncta along plasma membranes, and branch points and terminal growth cones in neurites. Colforsin 57-66 huntingtin Homo sapiens 68-78 9950152-3 1999 The expression of ERV-3 env mRNA increased after 48 h forskolin treatment, concurrently with increased intercellular fusion and production of human chorionic gonadotropin (beta-hCG) mRNA, a hormonal differentiation marker for trophoblast. Colforsin 54-63 endogenous retrovirus group K member 20 Homo sapiens 24-27 9852118-3 1998 Both forskolin and 8-(4-chlorophenylthio)adenosine 3"-5"-monophosphate (CPT-cAMP) prevented the activation of mTOR by insulin in adipocytes, but neither agent affected mTOR activity when added directly to the immunopurified protein. Colforsin 5-14 mechanistic target of rapamycin kinase Homo sapiens 110-114 10355282-6 1999 Nine (AC-1-AC-9) mammalian enzymes are stimulated by an "alpha" subunit of Gs-protein (Gs alpha) and by the diterpene forskolin, albeit to varying degrees (with AC-9 being least sensitive to forskolin). Colforsin 191-200 GNAS complex locus Homo sapiens 87-95 9852118-1 1998 Incubating 3T3-L1 adipocytes with forskolin, which increases intracellular cAMP by activating adenylate cyclase, mimicked rapamycin by attenuating the effect of insulin on stimulating the phosphorylation of four (S/T)P sites in PHAS-I, a downstream target of the mammalian target of rapamycin (mTOR) signaling pathway. Colforsin 34-43 insulin Homo sapiens 161-168 9852118-3 1998 Both forskolin and 8-(4-chlorophenylthio)adenosine 3"-5"-monophosphate (CPT-cAMP) prevented the activation of mTOR by insulin in adipocytes, but neither agent affected mTOR activity when added directly to the immunopurified protein. Colforsin 5-14 insulin Homo sapiens 118-125 9852118-1 1998 Incubating 3T3-L1 adipocytes with forskolin, which increases intracellular cAMP by activating adenylate cyclase, mimicked rapamycin by attenuating the effect of insulin on stimulating the phosphorylation of four (S/T)P sites in PHAS-I, a downstream target of the mammalian target of rapamycin (mTOR) signaling pathway. Colforsin 34-43 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 228-234 9852118-1 1998 Incubating 3T3-L1 adipocytes with forskolin, which increases intracellular cAMP by activating adenylate cyclase, mimicked rapamycin by attenuating the effect of insulin on stimulating the phosphorylation of four (S/T)P sites in PHAS-I, a downstream target of the mammalian target of rapamycin (mTOR) signaling pathway. Colforsin 34-43 mechanistic target of rapamycin kinase Homo sapiens 263-292 9852118-3 1998 Both forskolin and 8-(4-chlorophenylthio)adenosine 3"-5"-monophosphate (CPT-cAMP) prevented the activation of mTOR by insulin in adipocytes, but neither agent affected mTOR activity when added directly to the immunopurified protein. Colforsin 5-14 mechanistic target of rapamycin kinase Homo sapiens 168-172 9852118-1 1998 Incubating 3T3-L1 adipocytes with forskolin, which increases intracellular cAMP by activating adenylate cyclase, mimicked rapamycin by attenuating the effect of insulin on stimulating the phosphorylation of four (S/T)P sites in PHAS-I, a downstream target of the mammalian target of rapamycin (mTOR) signaling pathway. Colforsin 34-43 mechanistic target of rapamycin kinase Homo sapiens 294-298 9852118-5 1998 Forskolin and CPT-cAMP blocked the effect of insulin on increasing mTOR phosphorylation, which was assessed using mTAb1, an antibody whose binding is inhibited by phosphorylation of mTOR. Colforsin 0-9 insulin Homo sapiens 45-52 9852118-5 1998 Forskolin and CPT-cAMP blocked the effect of insulin on increasing mTOR phosphorylation, which was assessed using mTAb1, an antibody whose binding is inhibited by phosphorylation of mTOR. Colforsin 0-9 mechanistic target of rapamycin kinase Homo sapiens 67-71 9883885-4 1998 Forskolin, a stimulator of the adenylyl cyclase, and dibutyryl-cAMP reduced the effect of Lp(a) on MAPK phosphorylation and activation. Colforsin 0-9 lipoprotein(a) Homo sapiens 90-95 9852118-5 1998 Forskolin and CPT-cAMP blocked the effect of insulin on increasing mTOR phosphorylation, which was assessed using mTAb1, an antibody whose binding is inhibited by phosphorylation of mTOR. Colforsin 0-9 TGF-beta activated kinase 1/MAP3K7 binding protein 1 Mus musculus 114-119 9852118-5 1998 Forskolin and CPT-cAMP blocked the effect of insulin on increasing mTOR phosphorylation, which was assessed using mTAb1, an antibody whose binding is inhibited by phosphorylation of mTOR. Colforsin 0-9 mechanistic target of rapamycin kinase Homo sapiens 182-186 9852568-7 1998 Brief incubations with forskolin and 8-bromo-cAMP (8-Br-cAMP) were found to stimulate striatal DAT activity by increasing the Vmax of transport without affecting the Km. Colforsin 23-32 solute carrier family 6 member 3 Homo sapiens 95-98 9878114-7 1998 When stimulated with forskolin, an activator of cAMP-dependent PKC, CD44.3R3A transfectants were able to bind low but detectable level of fluorescent-conjugated HA (F-HA). Colforsin 21-30 CD44 molecule (Indian blood group) Homo sapiens 68-72 9843850-6 1998 The cystic fibrosis transmembrane conductance regulator channel blocker glibenclamide and the loop diuretic bumetanide partially decreased the forskolin-induced increase in short-circuit current. Colforsin 143-152 cystic fibrosis transmembrane conductance regulator Oryctolagus cuniculus 4-55 9853756-4 1998 Here we report that activation of Rap1 by forskolin and cAMP occurs independently of protein kinase A (also known as cAMP-activated protein kinase). Colforsin 42-51 RAP1A, member of RAS oncogene family Homo sapiens 34-38 9843763-5 1998 Increased intracellular cAMP (by basolateral addition of 100 micromol/l IBMX and 1 micromol/l forskolin) activated a sustained lumen-negative current (DeltaIsc = -42.4 +/- 7.2 microA/cm2) that was inhibited by basolateral trans-6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2, 2-dimethyl&2-chromane (10 micromol/l), a blocker of KvLQT1 channels. Colforsin 94-103 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 339-345 9838095-7 1998 On the other hand, an adenylyl cyclase activator forskolin and a cyclic AMP analog 8-Br-cyclic AMP markedly attenuated the effect of bFGF, which indicates the presence of a cyclic AMP-mediated negative regulatory mechanism, possibly the interference of Ras-Raf interaction. Colforsin 49-58 fibroblast growth factor 2 Rattus norvegicus 133-137 9843860-4 1998 Forskolin (an activator of CFTR) tripled fluid absorption across primary cultures of bovine tracheal epithelium but had no effect on human cells. Colforsin 0-9 CF transmembrane conductance regulator Bos taurus 27-31 9856973-5 1998 Similarly, the inhibition of forskolin (1 micromol/L)-induced cAMP accumulation caused by Ang II (10 pmol/L) was also abolished in bromocriptine-pretreated tubules. Colforsin 29-38 angiotensinogen Homo sapiens 90-96 9887962-9 1998 Telokin, the independently expressed C-terminus of myosin light chain kinase, is extensively phosphorylated during forskolin- and 8-br-cGMP-induced relaxation in situ. Colforsin 115-124 myosin light chain kinase, smooth muscle Oryctolagus cuniculus 0-7 9887962-9 1998 Telokin, the independently expressed C-terminus of myosin light chain kinase, is extensively phosphorylated during forskolin- and 8-br-cGMP-induced relaxation in situ. Colforsin 115-124 myosin light chain kinase, smooth muscle Oryctolagus cuniculus 51-76 10221587-12 1998 Concentrations of mRNA encoding SF-1 were increased (p < 0.05) to 157 and 149% of control values by LH and forskolin, respectively, 12 h following infusion and returned to control values by 24 h following either treatment. Colforsin 110-119 splicing factor 1 Homo sapiens 32-36 10221587-17 1998 In addition, although LH or forskolin increased luteal SF-1 mRNA 12 h following infusion, no increases in mRNA encoding StAR, P450scc, or 3beta-HSD were observed. Colforsin 28-37 splicing factor 1 Homo sapiens 55-59 9884079-6 1998 Prolonged incubation of cultured aortic VSMC with agents that increase VSMC cyclic AMP (forskolin or 8-bromo-cyclic AMP) produced marked time-dependent increases in PDE3 activity which correlated with increases in PDE3A and PDE3B RT PCR signals and a marked increase in particulate PDE3 activity and PDE3B protein. Colforsin 88-97 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 165-169 9884079-6 1998 Prolonged incubation of cultured aortic VSMC with agents that increase VSMC cyclic AMP (forskolin or 8-bromo-cyclic AMP) produced marked time-dependent increases in PDE3 activity which correlated with increases in PDE3A and PDE3B RT PCR signals and a marked increase in particulate PDE3 activity and PDE3B protein. Colforsin 88-97 phosphodiesterase 3A Rattus norvegicus 214-219 9884079-6 1998 Prolonged incubation of cultured aortic VSMC with agents that increase VSMC cyclic AMP (forskolin or 8-bromo-cyclic AMP) produced marked time-dependent increases in PDE3 activity which correlated with increases in PDE3A and PDE3B RT PCR signals and a marked increase in particulate PDE3 activity and PDE3B protein. Colforsin 88-97 phosphodiesterase 3B Rattus norvegicus 224-229 9884079-6 1998 Prolonged incubation of cultured aortic VSMC with agents that increase VSMC cyclic AMP (forskolin or 8-bromo-cyclic AMP) produced marked time-dependent increases in PDE3 activity which correlated with increases in PDE3A and PDE3B RT PCR signals and a marked increase in particulate PDE3 activity and PDE3B protein. Colforsin 88-97 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 214-218 9884079-6 1998 Prolonged incubation of cultured aortic VSMC with agents that increase VSMC cyclic AMP (forskolin or 8-bromo-cyclic AMP) produced marked time-dependent increases in PDE3 activity which correlated with increases in PDE3A and PDE3B RT PCR signals and a marked increase in particulate PDE3 activity and PDE3B protein. Colforsin 88-97 phosphodiesterase 3B Rattus norvegicus 300-305 9867210-6 1998 Further, it was found that AGE decreased the intracellular cyclic AMP concentrations in EC and that cyclic AMP agonists such as dibutyryl cyclic AMP, forskolin and PGI2 analogue reduced the AGE-stimulated PAI-1 production, suggesting the involvement of cyclic AMP in the AGE-signalling pathway. Colforsin 150-159 serpin family E member 1 Homo sapiens 205-210 9924808-5 1998 In contrast, incubation of mouse pituitary tumor AtT20 cells with CRH inhibited MAP kinase activity, an effect also mimicked by forskolin and inhibited by H89. Colforsin 128-137 corticotropin releasing hormone Mus musculus 66-69 9878303-10 1998 In the presence of LPS, both FSK and 8-Br-cAMP significantly reduced TNF-alpha release. Colforsin 29-32 tumor necrosis factor Mus musculus 69-78 9832124-1 1998 Culture of rat astrocytes in the presence of 10 microM forskolin, isoproterenol, a nonselective beta-adrenergic agonist, or 8-bromo-cyclic AMP increased transiently in a time-dependent manner the levels of G(i alpha2) and G(i alpha3) mRNAs as measured by northern blot analysis. Colforsin 55-64 G protein subunit alpha i3 Rattus norvegicus 222-232 9832124-3 1998 After 6-9 h of culture with forskolin or isoproterenol the amounts of G(i alpha2) and G(i alpha3) mRNAs were maximal (150-300% over control). Colforsin 28-37 G protein subunit alpha i3 Rattus norvegicus 86-96 9832124-7 1998 In contrast, forskolin induced only a modest increase in the quantity of G(i alpha3) protein (150% over control) despite a large increase of G(i alpha3) mRNA content. Colforsin 13-22 G protein subunit alpha i3 Rattus norvegicus 73-83 9832124-7 1998 In contrast, forskolin induced only a modest increase in the quantity of G(i alpha3) protein (150% over control) despite a large increase of G(i alpha3) mRNA content. Colforsin 13-22 G protein subunit alpha i3 Rattus norvegicus 141-151 9832124-10 1998 Culturing astrocytes in the presence of forskolin resulted in an increase in the half-lives of G(i alpha2) mRNA and G(i alpha3) mRNA by five- and twofold, respectively. Colforsin 40-49 G protein subunit alpha i3 Rattus norvegicus 116-126 9832124-11 1998 The relative transcription rate of the G(i alpha3) gene was slightly increased by approximately 1.3-1.5-fold in forskolin-treated cells but not that of G(i alpha2) gene. Colforsin 112-121 G protein subunit alpha i3 Rattus norvegicus 39-49 9878303-11 1998 For instance at 6 h in the presence of LPS and FSK or 8-Br-cAMP, TNF-alpha was 126 +/- 24 and 71.6 +/- 22 units/g tissue, respectively (P < 0.05 vs LPS alone). Colforsin 47-50 tumor necrosis factor Mus musculus 65-74 9878303-13 1998 Similar results were obtained with smooth muscle cells cultured from the coronary arteries; i.e., LPS stimulated TNF-alpha release which was inhibited in a concentration-dependent manner by a rise in intracellular cAMP induced by FSK. Colforsin 230-233 tumor necrosis factor Mus musculus 113-122 9853270-5 1998 Regulation of the hREN promoter activity was investigated using Y-1 adrenal cells that were transfected with the hREN-luciferase DNA and were treated with forskolin, calcium ionophore A23187, phorbol ester, angiotensin II (Ang II), or cytokines. Colforsin 155-164 renin Homo sapiens 18-22 9853270-7 1998 In transfected Y-1 cells, luciferase reporter expression was induced by forskolin, suppressed by the calcium ionophore A23187, and phorbol ester in a dose-dependent manner, but was unaffected by angiotensin II (Ang II). Colforsin 72-81 angiotensinogen Homo sapiens 211-217 9819380-5 1998 Forskolin treatment reduced binding to the DRE, and the time course paralleled that for an increase in prodynorphin gene expression. Colforsin 0-9 prodynorphin Homo sapiens 103-115 9845337-2 1998 Treatment of IEC-6 cells with the adenylate cyclase activator forskolin led to coordinate induction of C/EBP isoforms alpha, beta and delta at the mRNA and protein levels. Colforsin 62-71 CCAAT/enhancer binding protein gamma Rattus norvegicus 103-108 9879660-4 1998 Treatment of PC12 cells with a combination of agents (NGF, forskolin, and tetradecanoylphorbol acetate [TPA]) increased c-fos expression over that detected with NGF alone. Colforsin 59-68 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 120-125 9819228-11 1998 Finally, Dlx5 reverses Msx2 inhibition of OC promoter activation by FGF2/forskolin. Colforsin 73-82 distal-less homeobox 5 Rattus norvegicus 9-13 9819228-11 1998 Finally, Dlx5 reverses Msx2 inhibition of OC promoter activation by FGF2/forskolin. Colforsin 73-82 msh homeobox 2 Rattus norvegicus 23-27 9845337-4 1998 Forskolin treatment induced haptoglobin mRNA levels. Colforsin 0-9 haptoglobin Rattus norvegicus 28-39 9845337-6 1998 Site-specific mutations of both sites led to a decrease in transcriptional induction by forskolin, suggesting that C/EBP isoforms are involved in the cAMP-dependent regulation of the acute-phase protein gene haptoglobin in intestinal epithelial cells. Colforsin 88-97 CCAAT/enhancer binding protein gamma Rattus norvegicus 115-120 9845337-6 1998 Site-specific mutations of both sites led to a decrease in transcriptional induction by forskolin, suggesting that C/EBP isoforms are involved in the cAMP-dependent regulation of the acute-phase protein gene haptoglobin in intestinal epithelial cells. Colforsin 88-97 cathelicidin antimicrobial peptide Rattus norvegicus 150-154 9845337-6 1998 Site-specific mutations of both sites led to a decrease in transcriptional induction by forskolin, suggesting that C/EBP isoforms are involved in the cAMP-dependent regulation of the acute-phase protein gene haptoglobin in intestinal epithelial cells. Colforsin 88-97 haptoglobin Rattus norvegicus 208-219 9873152-1 1998 Modulatory effects of the activation of either protein kinase C (PKC) by phorbol 12,13-dibutyrate (PDBu) or protein kinase A (PKA) by forskolin on stimulant-evoked secretory processes in the perfused rat adrenal medulla were studied. Colforsin 134-143 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 108-124 9815137-5 1998 Immunofluorescence and biochemical studies indicate a shuttling of AQP-2-bearing vesicles after stimulation with vasopressin or forskolin. Colforsin 128-137 aquaporin 2 Rattus norvegicus 67-72 9815052-5 1998 Supramaximal concentrations of CCK-8 or CCh also reduced forskolin-induced potentiation of amylase release but did not reduce that induced by 8-bromo-cAMP. Colforsin 57-66 cholecystokinin Rattus norvegicus 31-34 9815052-8 1998 These results indicate that supramaximal concentrations of CCK-8 and CCh reduce the potentiating effect of VIP and forskolin on amylase secretion by inhibiting the adenylyl cyclase activity. Colforsin 115-124 cholecystokinin Rattus norvegicus 59-62 9806674-7 1998 Pretreatment of the H9c2 cells with ketamine, plus the combination of TNF-alpha and IFN-gamma, inhibited the reduction of ISO or FSK-induced intracellular cAMP accumulation caused by the proinflammatory cytokines alone. Colforsin 129-132 tumor necrosis factor Rattus norvegicus 70-79 9806674-7 1998 Pretreatment of the H9c2 cells with ketamine, plus the combination of TNF-alpha and IFN-gamma, inhibited the reduction of ISO or FSK-induced intracellular cAMP accumulation caused by the proinflammatory cytokines alone. Colforsin 129-132 interferon gamma Rattus norvegicus 84-93 9806674-8 1998 These results demonstrate that the combination of the proinflammatory cytokines TNF-alpha and IFN-gamma reduce poststimulation (ISO or FSK) intracellular cAMP accumulation. Colforsin 135-138 tumor necrosis factor Rattus norvegicus 80-89 9806674-8 1998 These results demonstrate that the combination of the proinflammatory cytokines TNF-alpha and IFN-gamma reduce poststimulation (ISO or FSK) intracellular cAMP accumulation. Colforsin 135-138 interferon gamma Rattus norvegicus 94-103 9873152-1 1998 Modulatory effects of the activation of either protein kinase C (PKC) by phorbol 12,13-dibutyrate (PDBu) or protein kinase A (PKA) by forskolin on stimulant-evoked secretory processes in the perfused rat adrenal medulla were studied. Colforsin 134-143 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 126-129 9774641-7 1998 In cells treated with both heregulin and forskolin there was a sustained accumulation of phospho-CREB, which was not observed in cells treated with either agent alone. Colforsin 41-50 cAMP responsive element binding protein 1 Homo sapiens 97-101 9786963-8 1998 NO release from PFs was also potentiated by L-Arg (ARG) (100 microM), forskolin (50 microM), and 8-bromo-cAMP (Br-cAMP) (1 mM) but not by 1,9-dideoxyforskolin (50 microM), a biologically inactive analog of forskolin. Colforsin 149-158 Rho guanine nucleotide exchange factor 12 Rattus norvegicus 44-49 9769421-15 1998 The response of the beta-AR-coupled adenylyl cyclase system to isoprenaline, Gpp(NH)p and forskolin was studied by measuring cAMP production. Colforsin 90-99 adrenergic receptor, beta 1 Mus musculus 20-27 9765424-8 1998 The ATF/CRE site is also essential for CD4 promoter activation by forskolin, an activator of adenylate cyclase. Colforsin 66-75 CD4 molecule Homo sapiens 39-42 9817596-7 1998 Stimulation of Sertoli cells with activators of the cAMP-protein kinase A (PKA) signaling pathway such as forskolin or FSH also increased NF-kappaB DNA binding activity. Colforsin 106-115 nuclear factor kappa B subunit 1 Homo sapiens 138-147 9879979-10 1998 Estradiol had no influence on DRG-Schwann cell proliferation, only replated secondary Schwann cells showed a slightly higher level of proliferation in presence of 100 nM E2 and 5 microM forskolin. Colforsin 186-195 dihydrolipoamide S-succinyltransferase Rattus norvegicus 170-178 9856469-4 1998 In rab3A-deficient synaptosomes, forskolin still enhances KCl- and sucrose-induced glutamate release but not ionomycin-induced release. Colforsin 33-42 RAB3A, member RAS oncogene family Homo sapiens 3-8 9763638-16 1998 Forskolin, an activator of endogenous adenylate cyclase, and 3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, mimicked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from imposed acid loads, as did Sp-cAMPS, a selective activator of cAMP-dependent protein kinase. Colforsin 0-9 glucose-6-phosphate isomerase Rattus norvegicus 189-192 9932109-5 1998 RESULTS: We show here that the cAMP-dependent protein kinase (PKA) effectors, dibutyryl-cAMP (dBut-cAMP) and forskolin, but not the inactive analog dideoxyforskolin, enhance the secretion of APP alpha and the intracellular production of its C-terminal counterpart (p10) in stably transfected HEK293 cells. Colforsin 109-118 S100 calcium binding protein A10 Homo sapiens 265-268 9932109-9 1998 We show here that the dBut-cAMP and forskolin-induced increase of APP alpha and A beta s secretions is not prevented by the transcription inhibitor actinomycin D. Colforsin 36-45 amyloid beta precursor protein Homo sapiens 80-86 9859862-13 1998 The second messenger analogue dibutyryl cAMP (db cAMP) and the cAMP elevating factor (forskolin) mimicked the effects of hCG by stimulating a dose-dependent increase of trophoblastic cell UEG-3) invasion. Colforsin 86-95 chorionic gonadotropin subunit beta 5 Homo sapiens 121-124 9859864-7 1998 Forskolin and methotrexate, which induce biochemical differentiation/ growth arrest in choriocarcinoma cells, stimulate eNOS mRNA and protein synthesis, but cannot overcome the decline of eNOS polypeptide levels during hypoxic incubation. Colforsin 0-9 nitric oxide synthase 3 Homo sapiens 120-124 9786935-3 1998 Treatment of SK-UT-1 cells with forskolin or 8-bromo-cAMP strongly increased biglycan mRNA and this effect was transcriptional as shown by transient transfection experiments with biglycan promoter-luciferase reporter fusion genes. Colforsin 32-41 biglycan Homo sapiens 77-85 9786935-3 1998 Treatment of SK-UT-1 cells with forskolin or 8-bromo-cAMP strongly increased biglycan mRNA and this effect was transcriptional as shown by transient transfection experiments with biglycan promoter-luciferase reporter fusion genes. Colforsin 32-41 biglycan Homo sapiens 179-187 9765227-2 1998 In a CHO clone stably expressing EDG1 receptor (CHO-EDG1 cells), SP induced increases in the production of inositol phosphates and the [Ca2+]i and inhibited forskolin-induced increase in the cellular cAMP content, all in a manner sensitive to pertussis toxin. Colforsin 157-166 sphingosine-1-phosphate receptor 1 Homo sapiens 33-37 9765227-2 1998 In a CHO clone stably expressing EDG1 receptor (CHO-EDG1 cells), SP induced increases in the production of inositol phosphates and the [Ca2+]i and inhibited forskolin-induced increase in the cellular cAMP content, all in a manner sensitive to pertussis toxin. Colforsin 157-166 sphingosine-1-phosphate receptor 1 Homo sapiens 52-56 9763638-17 1998 The effect of forskolin on steady-state pHi was blocked by pre-treatment with Rp-cAMPS whereas the effect of Sp-cAMPS was enhanced by pre-treatment with the protein phosphatase inhibitor, okadaic acid. Colforsin 14-23 glucose-6-phosphate isomerase Rattus norvegicus 40-43 9763638-17 1998 The effect of forskolin on steady-state pHi was blocked by pre-treatment with Rp-cAMPS whereas the effect of Sp-cAMPS was enhanced by pre-treatment with the protein phosphatase inhibitor, okadaic acid. Colforsin 14-23 calmodulin 2, pseudogene 1 Rattus norvegicus 81-86 9763638-16 1998 Forskolin, an activator of endogenous adenylate cyclase, and 3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, mimicked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from imposed acid loads, as did Sp-cAMPS, a selective activator of cAMP-dependent protein kinase. Colforsin 0-9 glucose-6-phosphate isomerase Rattus norvegicus 206-209 9763638-16 1998 Forskolin, an activator of endogenous adenylate cyclase, and 3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, mimicked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from imposed acid loads, as did Sp-cAMPS, a selective activator of cAMP-dependent protein kinase. Colforsin 0-9 calmodulin 2, pseudogene 1 Rattus norvegicus 254-259 9766444-6 1998 The differentiation response to transfected p53 with or without INF-gamma was inhibited by cyclic adenosine monophosphate (cAMP)-inducing agents (dibutyryl cyclic adenosine 3":5"-monophosphate, forskolin, and 3-isobutyl-1-methylxanthine) in a dose-dependent manner. Colforsin 194-203 tumor protein p53 Homo sapiens 44-47 9755049-4 1998 Our studies demonstrate that, in transfected NIH-3T3 cells, maximal enhancements of forskolin-dependent DeltaF508-CFTR activity are greatest with genistein, IBMX, and NS004. Colforsin 84-93 cystic fibrosis transmembrane conductance regulator Mus musculus 114-118 9755049-6 1998 Because forskolin and calyculin A increase in vivo phosphorylation of cAMP binding response element (CREB), the inability of milrinone, genistein, CPX, and NS004 to increase CREB phosphorylation suggests that they do not stimulate protein kinase A or inhibit phosphatase activity. Colforsin 8-17 cAMP responsive element binding protein 1 Mus musculus 101-105 9788971-3 1998 In primary cultures of renal juxtaglomerular cells (JG) established from wild-type, cGKI-/-, and cGKII-/- mice, the adenylate cyclase activator forskolin stimulated renin secretion similarly in all genotypes tested. Colforsin 144-153 protein kinase, cGMP-dependent, type I Mus musculus 84-88 9788971-3 1998 In primary cultures of renal juxtaglomerular cells (JG) established from wild-type, cGKI-/-, and cGKII-/- mice, the adenylate cyclase activator forskolin stimulated renin secretion similarly in all genotypes tested. Colforsin 144-153 protein kinase, cGMP-dependent, type II Mus musculus 97-102 9788971-3 1998 In primary cultures of renal juxtaglomerular cells (JG) established from wild-type, cGKI-/-, and cGKII-/- mice, the adenylate cyclase activator forskolin stimulated renin secretion similarly in all genotypes tested. Colforsin 144-153 renin Rattus norvegicus 165-170 9788971-4 1998 8-bromo-cGMP attenuated basal and forskolin-stimulated renin secretion in cultures from wild-type and cGKI-/-, but had no effect in cells isolated from cGKII-/- mice. Colforsin 34-43 renin Rattus norvegicus 55-60 9788971-4 1998 8-bromo-cGMP attenuated basal and forskolin-stimulated renin secretion in cultures from wild-type and cGKI-/-, but had no effect in cells isolated from cGKII-/- mice. Colforsin 34-43 protein kinase, cGMP-dependent, type I Mus musculus 102-107 9751489-3 1998 GLP-1 secretion was stimulated in a dose-dependent fashion by activation of protein kinase A or C with forskolin or phorbol 12,13-dibutyrate, respectively (by 2.3 +/- 0.5-fold at 100 microM and 4.3 +/- 0.6-fold at 0.3 microM, respectively; P < 0.01-0.001). Colforsin 103-112 glucagon Mus musculus 0-5 9761782-7 1998 Forskolin (1 microM), an adenylate cyclase activator, induced a 48% increase in lipolysis in human adipocytes (P<0.05); this effect was reversed by 100 nM agouti (P<005), demonstrating that the antilipolytic effect of agouti is distal to the ACTH receptor. Colforsin 0-9 melanocortin 2 receptor Homo sapiens 248-261 9768673-5 1998 Leptin production and gene expression in BeWo cells were increased by treatment with forskolin. Colforsin 85-94 leptin Homo sapiens 0-6 9792416-4 1998 The GFP-AQP2(NT) chimera trafficked in a regulated pathway from intracellular vesicles to the basolateral plasma membrane in response to vasopressin or forskolin stimulation of cells. Colforsin 152-161 aquaporin 2 Sus scrofa 4-16 9768668-5 1998 3), GHRP plus forskolin (adenylate cyclase activator), but not GHRP plus phorbol 12-myristate 13-acetate (protein kinase C activator), additively enhanced the GH response. Colforsin 14-23 growth hormone 1 Homo sapiens 4-6 9768673-6 1998 The forskolin-induced increase in leptin production was completely suppressed by H89, an inhibitor of protein kinase A. Colforsin 4-13 leptin Homo sapiens 34-40 9768673-9 1998 Leptin production and gene expression in explant cultures of placental tissue at both stages of pregnancy were augmented markedly by treatment with forskolin or PMA. Colforsin 148-157 leptin Homo sapiens 0-6 9751193-8 1998 Thus, forskolin decreased in parallel ACC activity and intracellular malonyl-CoA levels, whereas it stimulated CPT-I activity and [14C]palmitate oxidation to both ketone bodies and CO2. Colforsin 6-15 carnitine palmitoyltransferase 1B Rattus norvegicus 111-116 9742135-7 1998 Forskolin, which increases intracellular cAMP levels, induced a 1.5- to 1.6-fold increase in the number of TH-immunostained neurons. Colforsin 0-9 tyrosine hydroxylase Mus musculus 107-109 9795339-10 1998 Stimulation of the protein kinase A pathway by simultaneous incubation of ACTH (10 nM) or forskolin (10 microM) together with AG was not able to overcome the steroid biosynthesis blockade, but reversed the inhibitory effects of AG on the ACTH-R mRNA expression. Colforsin 90-99 melanocortin 2 receptor Homo sapiens 238-244 9759900-5 1998 Forskolin and dibutyryl cAMP, which increase intracellular cAMP, stimulated IL-8 in a fashion similar to that of PGE2. Colforsin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 76-80 9759900-8 1998 However, PGE2, forskolin, and PMA enhanced the stability of IL-8 mRNA transcripts, suggesting the involvement of posttranscriptional regulation. Colforsin 15-24 C-X-C motif chemokine ligand 8 Homo sapiens 60-64 9765331-6 1998 IL-10 dose-dependently inhibited the increased T84 permeability and the reduced responsiveness to forskolin that were evoked by coculture with SEB-activated PBMC or T + B cells. Colforsin 98-107 interleukin 10 Homo sapiens 0-5 9771969-4 1998 Endogenous insulin-like growth factor II mRNA derived from the P3 as well as transfected P3 promoter activity were modestly and consistently increased to the same extent following treatment of the rhabdomyosarcoma cell line RD with forskolin, a compound implicated in AP-2 transactivation. Colforsin 232-241 transcription factor AP-2 alpha Homo sapiens 268-272 9737994-11 1998 Forskolin (400 microM), an activator of the adenylate cyclase that results in PKA activation, shifted the HERG activation curve by 14 mV. Colforsin 0-9 potassium voltage-gated channel subfamily H member 2 Homo sapiens 106-110 9802422-5 1998 Of these agents, PMA and bFGF markedly induced NPY-IR production by rat as well as human astrocytes, forskolin induced NPY-IR production by human but not rat astrocytes, and neither BDNF nor substance P induced NPY-IR production by rat or human astrocytes. Colforsin 101-110 neuropeptide Y Homo sapiens 119-122 9802422-5 1998 Of these agents, PMA and bFGF markedly induced NPY-IR production by rat as well as human astrocytes, forskolin induced NPY-IR production by human but not rat astrocytes, and neither BDNF nor substance P induced NPY-IR production by rat or human astrocytes. Colforsin 101-110 neuropeptide Y Homo sapiens 119-122 9802424-11 1998 NPY augmented forskolin-stimulated luciferase activity from 11- to 15-fold, but had no significant effect on thapsigargin-induced luciferase activity. Colforsin 14-23 neuropeptide Y Homo sapiens 0-3 9802424-14 1998 Pretreatment with CREB antisense, but not the sense oligodeoxynucleotides, inhibited forskolin-, thapsigargin- and NPY-stimulated luciferase activity. Colforsin 85-94 cAMP responsive element binding protein 1 Homo sapiens 18-22 9808467-2 1998 We have found that inhibitors of tPA inhibit the late phase of long-term potentiation (L-LTP) induced by either forskolin or tetanic stimulation in the hippocampal mossy fiber and Schaffer collateral pathways. Colforsin 112-121 chromosome 20 open reading frame 181 Homo sapiens 33-36 9808467-4 1998 Exposure of granule cells in culture to forskolin results in secretion of tPA, elongation of mossy fiber axons, and formation of new, active presynaptic varicosities contiguous to dendritic clusters of the glutamate receptor R1. Colforsin 40-49 chromosome 20 open reading frame 181 Homo sapiens 74-77 9771969-4 1998 Endogenous insulin-like growth factor II mRNA derived from the P3 as well as transfected P3 promoter activity were modestly and consistently increased to the same extent following treatment of the rhabdomyosarcoma cell line RD with forskolin, a compound implicated in AP-2 transactivation. Colforsin 232-241 insulin like growth factor 2 Homo sapiens 11-40 9724791-3 1998 L-054,522 is a full agonist based on its inhibition of forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary-K1 cells stably expressing sst2. Colforsin 55-64 somatostatin receptor 2 Rattus norvegicus 155-159 9730948-4 1998 As measured by I- efflux, maximal CFTR activity with PGF and FSK was equivalent and fivefold greater than that with PMA. Colforsin 61-64 cystic fibrosis transmembrane conductance regulator Mus musculus 34-38 9730948-5 1998 Both PGF and PMA had additive effects on FSK-dependent CFTR activity. Colforsin 41-44 cystic fibrosis transmembrane conductance regulator Mus musculus 55-59 9730948-6 1998 PMA did not increase cellular cAMP, and maximal PGF-dependent CFTR activity occurred with approximately 20% of the cellular cAMP observed with FSK-dependent activation. Colforsin 143-146 cystic fibrosis transmembrane conductance regulator Mus musculus 62-66 9730948-9 1998 As judged by protease digestion, the sites of in vivo CFTR phosphorylation with FSK and PMA differed. Colforsin 80-83 cystic fibrosis transmembrane conductance regulator Mus musculus 54-58 9786508-7 1998 On the other hand, acute stimulation of adenylyl cyclase by secretin, iloprost, NaF and forskolin was the same in GRK2 overexpressing cells and plasmid-transfected control cells. Colforsin 88-97 G protein-coupled receptor kinase 2 Mus musculus 114-118 9758168-7 1998 In +/+ astrocytes, ET-1 (1 nM) stimulated cAMP accumulation, and the ET(B) receptor-selective agonist IRL 1620 (1 nM) suppressed 10 microM forskolin-induced cAMP accumulation, suggesting Gs coupling to the ET(A) receptor and Gi/o coupling to the ET(B) receptor. Colforsin 139-148 endothelin receptor type A Rattus norvegicus 206-211 9758168-8 1998 On the other hand, ET-1 did not increase cAMP accumulation in sl/sl astrocytes, although ET-1 (1 nM) suppressed the forskolin-induced response, suggesting Gi/o coupling to the ET(A) receptor. Colforsin 116-125 endothelin receptor type A Rattus norvegicus 176-181 9721722-7 1998 The fastest activation of GalNAc-T was achieved with forskolin, yielding up to 160% of the initial activity within 30 min of effector incubation. Colforsin 53-62 beta-1,4-N-acetyl-galactosaminyl transferase 1 Mus musculus 26-34 9721722-10 1998 In particular, the biosynthesis of GM1 was specifically elevated within 2 h of incubation with forskolin. Colforsin 95-104 coenzyme Q10A Mus musculus 35-38 9818729-11 1998 The cAMP enhancers, caffeine, NaF and forskolin, significantly increased the thymulin-stimulated release of PRL and TSH, while trifluoperazine, a protein kinase C inhibitor, had no effect. Colforsin 38-47 prolactin Rattus norvegicus 108-111 9728041-9 1998 The effect of IL-4 (50 ng/ml), PGE2 (1 microM), and forskolin (10 microM) on cyclin D1 protein expression in 10% FBS-stimulated human airway smooth muscle cells was also examined. Colforsin 52-61 cyclin D1 Homo sapiens 77-86 9721191-4 1998 Dibutyryl cAMP (dbcAMP) or the adenylate cyclase activator, forskolin, increased RBP mRNA levels >6-fold at 24 h. Increases in RBP mRNA were dose dependent over the range of 10 microM-1 mM for dbcAMP and 0.5-10 microM for forskolin. Colforsin 60-69 retinol binding protein 4, plasma Mus musculus 81-84 9721191-4 1998 Dibutyryl cAMP (dbcAMP) or the adenylate cyclase activator, forskolin, increased RBP mRNA levels >6-fold at 24 h. Increases in RBP mRNA were dose dependent over the range of 10 microM-1 mM for dbcAMP and 0.5-10 microM for forskolin. Colforsin 60-69 retinol binding protein 4, plasma Mus musculus 130-133 9721191-4 1998 Dibutyryl cAMP (dbcAMP) or the adenylate cyclase activator, forskolin, increased RBP mRNA levels >6-fold at 24 h. Increases in RBP mRNA were dose dependent over the range of 10 microM-1 mM for dbcAMP and 0.5-10 microM for forskolin. Colforsin 225-234 retinol binding protein 4, plasma Mus musculus 130-133 9776362-11 1998 SRIF (3 pM-3 nM) also caused concentration-dependent inhibition of forskolin-stimulated cyclic AMP formation in CHO-sst2(a) cells (pIC50 10.5) and CHO-sst2(b) cells (pIC50 10.4). Colforsin 67-76 somatostatin Mus musculus 0-4 9776362-11 1998 SRIF (3 pM-3 nM) also caused concentration-dependent inhibition of forskolin-stimulated cyclic AMP formation in CHO-sst2(a) cells (pIC50 10.5) and CHO-sst2(b) cells (pIC50 10.4). Colforsin 67-76 somatostatin receptor 2 Mus musculus 116-120 9788104-5 1998 RESULTS: TGF-beta 1-induced collagen synthesis in HCC SMC was inhibited by receptor-mediated (PGE1) and non-receptor-mediated (forskolin) increases in cAMP synthesis, as well as the cell-permeable analog, dibutyryl cAMP. Colforsin 127-136 transforming growth factor beta 1 Homo sapiens 9-19 9706871-6 1998 The IL-6 synthesis induced by cholera toxin, forskolin, or dibutyryl cAMP was inhibited by sphingosine. Colforsin 45-54 interleukin 6 Mus musculus 4-8 9730910-3 1998 PKA activity elicited both by forskolin and angiotensin II is suppressed in cells expressing this fusion protein (PKIalpha-eGFP), but platelet-derived growth factor-BB does not stimulate PKA activity in this preparation. Colforsin 30-39 cAMP-dependent protein kinase inhibitor alpha Rattus norvegicus 114-122 9730910-4 1998 PKIalpha-eGFP expression fully inhibits the forskolin-stimulated down-regulation of AT1-R mRNA levels and blocks 50% of the effect elicited by angiotensin II. Colforsin 44-53 cAMP-dependent protein kinase inhibitor alpha Rattus norvegicus 0-8 9730910-4 1998 PKIalpha-eGFP expression fully inhibits the forskolin-stimulated down-regulation of AT1-R mRNA levels and blocks 50% of the effect elicited by angiotensin II. Colforsin 44-53 angiotensin II receptor, type 1b Rattus norvegicus 84-89 9707637-1 1998 In the present study, we have used the two-electrode voltage-clamp and patch-clamp techniques to study the effects of forskolin and cAMP on the ROMK1 channels, which are believed to be the native K+ secretory channels in the kidney. Colforsin 118-127 potassium inwardly rectifying channel subfamily J member 1 S homeolog Xenopus laevis 144-149 9731216-6 1998 Treatment with forskolin led to a dose dependent inhibition of the 2.5kg-20 alpha-HSD-luciferase construct. Colforsin 15-24 aldo-keto reductase family 1, member C3 Rattus norvegicus 73-85 9707637-3 1998 In contrast, application of 1 microM forskolin, within 3 min, significantly increased whole-cell K+ current by 35%, when ROMK1 channels were coexpressed with the A kinase anchoring protein AKAP79, which was cloned from neuronal tissue. Colforsin 37-46 potassium inwardly rectifying channel subfamily J member 1 S homeolog Xenopus laevis 121-126 9705199-3 1998 To elucidate the mechanism of this induction, we first studied the effects of cAMP on phenobarbital-induced CYP3A31 expression using forskolin and N6,O2"-dibutyryl cAMP in hepatocyte cultures. Colforsin 133-142 cytochrome P450 3A31 Mesocricetus auratus 108-115 9698308-6 1998 In addition to inhibiting mGluR modulation of excitatory synaptic transmission, we found that activation of PKC reduces inhibition of forskolin-stimulated cAMP accumulation by group II and group III mGluRs, suggesting that the effect of PKC on mGluR signaling is not specific to their effects on neurotransmitter release. Colforsin 134-143 proline rich transmembrane protein 2 Homo sapiens 108-111 9698308-6 1998 In addition to inhibiting mGluR modulation of excitatory synaptic transmission, we found that activation of PKC reduces inhibition of forskolin-stimulated cAMP accumulation by group II and group III mGluRs, suggesting that the effect of PKC on mGluR signaling is not specific to their effects on neurotransmitter release. Colforsin 134-143 proline rich transmembrane protein 2 Homo sapiens 237-240 9705199-4 1998 At 100 microM, forskolin significantly inhibited both the phenobarbital-induced CYP3A31 mRNAs expression and the testosterone 6beta-hydroxylation activity related to the CYP3A subfamily in rats, whereas 0.1 microM forskolin potentiated the phenobarbital induction of CYP3A31 mRNA and the testosterone 6beta-hydroxylation activity. Colforsin 15-24 cytochrome P450 3A31 Mesocricetus auratus 80-87 9705199-4 1998 At 100 microM, forskolin significantly inhibited both the phenobarbital-induced CYP3A31 mRNAs expression and the testosterone 6beta-hydroxylation activity related to the CYP3A subfamily in rats, whereas 0.1 microM forskolin potentiated the phenobarbital induction of CYP3A31 mRNA and the testosterone 6beta-hydroxylation activity. Colforsin 15-24 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 80-85 9710271-4 1998 We now report that forskolin, but not depolarization or growth factors, induces PIM-1 expression in PC12 cells. Colforsin 19-28 Pim-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 80-85 9705199-4 1998 At 100 microM, forskolin significantly inhibited both the phenobarbital-induced CYP3A31 mRNAs expression and the testosterone 6beta-hydroxylation activity related to the CYP3A subfamily in rats, whereas 0.1 microM forskolin potentiated the phenobarbital induction of CYP3A31 mRNA and the testosterone 6beta-hydroxylation activity. Colforsin 15-24 cytochrome P450 3A31 Mesocricetus auratus 267-274 9710271-5 1998 PIM-1 is an immediate early gene induced in response to forskolin stimulation. Colforsin 56-65 Pim-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 0-5 9698608-5 1998 Acute heterologous beta2AR desensitization was characterized by an approximately 20% and 30% loss of maximal responsiveness to ISO challenge when cells were pretreated with forskolin and prostaglandin E2 (PGE2), respectively. Colforsin 173-182 adrenoceptor beta 2 Homo sapiens 19-26 9721879-9 1998 In CEM-C1 cells, Dex alone did not affect c-Myc; however, Dex plus forskolin suppressed c-Myc levels. Colforsin 67-76 MYC proto-oncogene, bHLH transcription factor Homo sapiens 88-93 9721879-11 1998 In these, forskolin (with or without Dex) caused a similar increase in cAMP (approximately 300-fold) and phospho-cAMP-responsive element binding protein (approximately 4-5-fold) levels, whereas total cAMP-responsive element binding protein expression was not affected. Colforsin 10-19 cathelicidin antimicrobial peptide Homo sapiens 71-75 9721879-11 1998 In these, forskolin (with or without Dex) caused a similar increase in cAMP (approximately 300-fold) and phospho-cAMP-responsive element binding protein (approximately 4-5-fold) levels, whereas total cAMP-responsive element binding protein expression was not affected. Colforsin 10-19 cathelicidin antimicrobial peptide Homo sapiens 113-117 9721879-11 1998 In these, forskolin (with or without Dex) caused a similar increase in cAMP (approximately 300-fold) and phospho-cAMP-responsive element binding protein (approximately 4-5-fold) levels, whereas total cAMP-responsive element binding protein expression was not affected. Colforsin 10-19 cathelicidin antimicrobial peptide Homo sapiens 113-117 9788291-5 1998 While after treatment with forskolin for 24 h, the cells retained the ability to respond to ET-1-induced Ca2+ mobilization to the same extent as the control group. Colforsin 27-36 endothelin 1 Canis lupus familiaris 92-96 9888553-2 1998 The protein kinase A (PKA) pathway agonists forskolin, dibutyryl cAMP and ACTH caused a 5-10 fold increase in 11beta-HSD2 mRNA as determined by semiquantitative PCR. Colforsin 44-53 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 4-20 9888553-2 1998 The protein kinase A (PKA) pathway agonists forskolin, dibutyryl cAMP and ACTH caused a 5-10 fold increase in 11beta-HSD2 mRNA as determined by semiquantitative PCR. Colforsin 44-53 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 22-25 9888553-2 1998 The protein kinase A (PKA) pathway agonists forskolin, dibutyryl cAMP and ACTH caused a 5-10 fold increase in 11beta-HSD2 mRNA as determined by semiquantitative PCR. Colforsin 44-53 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 110-121 9788291-7 1998 Forskolin (1-100 microM) inhibited the ET-1-induced increase in [Ca2+]i, but the lower concentrations had little effect on this response. Colforsin 0-9 endothelin 1 Canis lupus familiaris 39-43 9788291-10 1998 The water-soluble forskolin analogue L-858051, 7-deacetyl-7beta-(gamma-N-methylpiperazino)-butyryl forskolin, significantly inhibited ET-1-stimulated IPs accumulation. Colforsin 18-27 endothelin 1 Canis lupus familiaris 134-138 9683628-3 1998 The permeant analogs dibutyryl cyclic AMP and 8-bromo-cyclic AMP, as well as the pharmacological activator of adenylate cyclase forskolin, similarly decreased by about 35% the net endocytic accumulation of the fluid-phase tracer horseradish peroxidase at intervals >5 minutes in v-Src-transformed cells but not in the non-transformed parental Rat-1 cell line. Colforsin 128-137 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 284-287 9694969-4 1998 Exposure of CATH.a and SH-SY5Y cells to forskolin, a direct activator of adenylyl cyclase, resulted in a time-dependent decrease in levels of immunoreactivity of C and the two types of R (RI and RII). Colforsin 40-49 cathepsin H Mus musculus 12-16 9694942-3 1998 Determination of high-affinity [3H]forskolin binding to intact cells, which provides a direct parameter for the binding of the activated alpha-subunit of Gs (Gsalpha) to AC, revealed that the enhancement of AC activity after opioid withdrawal is not caused by an increased stimulation of effector activity by Gsalpha. Colforsin 35-44 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 158-165 9694942-4 1998 Although not a direct function of Gs, the expression of AC supersensitivity required Gsalpha-mediated stimulation of AC, because 1) the enhancement of AC activity after opioid withdrawal was observed only in the presence of low, but not of high concentrations of forskolin, and 2) chemical inactivation of Gsalpha by low pH pretreatment abolished the induction of AC supersensitivity. Colforsin 263-272 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 85-92 9660876-9 1998 Binding of SPP to Edg-1 resulted in inhibition of forskolin-stimulated cAMP accumulation, in a pertussis toxin-sensitive manner. Colforsin 50-59 sphingosine-1-phosphate receptor 1 Homo sapiens 18-23 9717846-4 1998 Rather, induction of PR mRNA depends on the differentiation of granulosa cells in response to E and a physiological amount of FSH followed by exposure to agonists (elevated levels of LH, FSH, and forskolin) that markedly increase cAMP. Colforsin 196-205 progesterone receptor Rattus norvegicus 21-23 9717846-5 1998 Induction of PR mRNA by forskolin is blocked by the A-kinase inhibitor H89 and cycloheximide but not by the E antagonist, ICI 164,384. Colforsin 24-33 progesterone receptor Rattus norvegicus 13-15 9717846-7 1998 When distal and proximal PR promoter-reporter constructs that are responsive to E in other cell types were transiently transfected into differentiated granulosa cells, forskolin, but not E, induced activity. Colforsin 168-177 progesterone receptor Rattus norvegicus 25-27 9717846-11 1998 The GC-rich region of the distal PR promoter bound Sp1 and Sp3 but not C/EBPalpha/beta, indicating that factors binding to ERE3 interact synergistically with Sp1/Sp3 to confer increased responsiveness of the distal promoter to forskolin. Colforsin 227-236 progesterone receptor Rattus norvegicus 33-35 9717848-8 1998 Furthermore, a CRH promoter containing this mutation exhibited a diminished response to forskolin. Colforsin 88-97 corticotropin releasing hormone Homo sapiens 15-18 9677418-3 1998 Hypoxia-induced phosphorylation of CREB was more robust than that induced by any other stimulus tested, including forskolin, depolarization, and osmotic stress. Colforsin 114-123 cAMP responsive element binding protein 1 Rattus norvegicus 35-39 9671794-6 1998 Expression of either cGK II or cGK I in JG cells by using adenoviral vectors enhanced the inhibition of forskolin-stimulated renin release by 8-pCPT-cGMP to 50%. Colforsin 104-113 protein kinase cGMP-dependent 2 Rattus norvegicus 21-27 9667962-11 1998 Antagonist activity of these BIs was confirmed by measuring the ability of selected compounds to reverse NPY-induced forskolin-stimulated cyclic AMP. Colforsin 117-126 neuropeptide Y Homo sapiens 105-108 9685625-6 1998 In HEK-293 cells, human GALR2 couples both to Galphaq/11 to stimulate phospholipase C and increase intracellular calcium levels and to Galphai/o to inhibit forskolin-stimulated intracellular cAMP accumulation. Colforsin 156-165 galanin receptor 2 Homo sapiens 24-29 9704017-5 1998 Forskolin added to LNCaP cells increased MSP mRNA to 6-fold within 12 h. These results suggest that the expression of MSP gene is regulated by cAMP via the CRE present in the promoter. Colforsin 0-9 microseminoprotein beta Homo sapiens 41-44 9704017-5 1998 Forskolin added to LNCaP cells increased MSP mRNA to 6-fold within 12 h. These results suggest that the expression of MSP gene is regulated by cAMP via the CRE present in the promoter. Colforsin 0-9 microseminoprotein beta Homo sapiens 118-121 9651211-4 1998 Secretin, a peptide chemically related to VIP, or forskolin increased VIP levels above those seen in ganglia cultured in control medium, whereas treatment with VIP or secretin increased the level of peptide histidine isoleucine (PHI), a peptide coded for by the same mRNA that encodes VIP. Colforsin 50-59 vasoactive intestinal peptide Rattus norvegicus 70-73 9651211-4 1998 Secretin, a peptide chemically related to VIP, or forskolin increased VIP levels above those seen in ganglia cultured in control medium, whereas treatment with VIP or secretin increased the level of peptide histidine isoleucine (PHI), a peptide coded for by the same mRNA that encodes VIP. Colforsin 50-59 vasoactive intestinal peptide Rattus norvegicus 70-73 9651211-4 1998 Secretin, a peptide chemically related to VIP, or forskolin increased VIP levels above those seen in ganglia cultured in control medium, whereas treatment with VIP or secretin increased the level of peptide histidine isoleucine (PHI), a peptide coded for by the same mRNA that encodes VIP. Colforsin 50-59 vasoactive intestinal peptide Rattus norvegicus 70-73 9651211-5 1998 VIP or forskolin also increased VIP-PHI mRNA. Colforsin 7-16 vasoactive intestinal peptide Rattus norvegicus 32-35 9793684-9 1998 Furthermore, direct activation of the cellular adenylyl cyclase activity by treatment with forskolin alone induced a prompt Ca2+ signal in the presence, but not in the absence, of extracellular Ca2+, identical results were obtained with the cell permeable cAMP analogue 8-bromo-cAMP. Colforsin 91-100 cathelicidin antimicrobial peptide Homo sapiens 256-260 9688835-8 1998 Furthermore, stimulation of isolated parietal cells, distal colonic crypts, and pancreatic cells with the adenylyl cyclase activator forskolin leads to the appearance of a higher molecular weight form of pp40/lasp-1, a finding which is consistent with an increase in protein phosphorylation. Colforsin 133-142 LIM and SH3 domain protein 1 Oryctolagus cuniculus 204-208 9688835-8 1998 Furthermore, stimulation of isolated parietal cells, distal colonic crypts, and pancreatic cells with the adenylyl cyclase activator forskolin leads to the appearance of a higher molecular weight form of pp40/lasp-1, a finding which is consistent with an increase in protein phosphorylation. Colforsin 133-142 LIM and SH3 domain protein 1 Oryctolagus cuniculus 209-215 9793684-9 1998 Furthermore, direct activation of the cellular adenylyl cyclase activity by treatment with forskolin alone induced a prompt Ca2+ signal in the presence, but not in the absence, of extracellular Ca2+, identical results were obtained with the cell permeable cAMP analogue 8-bromo-cAMP. Colforsin 91-100 cathelicidin antimicrobial peptide Homo sapiens 278-282 9645677-2 1998 Short exposure (10 min) of h mt1 melatonin receptors to melatonin (400 pM) inhibited forskolin-stimulated cAMP formation, cAMP-dependent protein kinase activity, and phosphorylation of the cAMP response element-binding protein. Colforsin 85-94 metallothionein-1 Cricetulus griseus 29-32 9787829-7 1998 Caffeine and forskolin were also effective relaxants of contractions evoked by ET-1 in both veins, suggesting relaxation by elevated levels of cAMP. Colforsin 13-22 endothelin 1 Bos taurus 79-83 9645711-3 1998 FSH-induced phosphorylation of p38 MAPK was blocked by pretreatment with the protein kinase A (PKA) inhibitor H89 and mimicked by the cAMP generating agonist forskolin, indicating that FSH-induced cAMP production and PKA activation are necessary and sufficient for the activation of p38 MAPK in GC. Colforsin 158-167 mitogen activated protein kinase 14 Rattus norvegicus 31-34 9645711-3 1998 FSH-induced phosphorylation of p38 MAPK was blocked by pretreatment with the protein kinase A (PKA) inhibitor H89 and mimicked by the cAMP generating agonist forskolin, indicating that FSH-induced cAMP production and PKA activation are necessary and sufficient for the activation of p38 MAPK in GC. Colforsin 158-167 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 217-220 9645711-3 1998 FSH-induced phosphorylation of p38 MAPK was blocked by pretreatment with the protein kinase A (PKA) inhibitor H89 and mimicked by the cAMP generating agonist forskolin, indicating that FSH-induced cAMP production and PKA activation are necessary and sufficient for the activation of p38 MAPK in GC. Colforsin 158-167 mitogen activated protein kinase 14 Rattus norvegicus 283-286 9645675-6 1998 PKC stimulation potentiated forskolin-induced cAMP accumulation to a greater degree in POA, but not HYP, slices from estrogen-treated OVX female rats. Colforsin 28-37 protein kinase C, gamma Rattus norvegicus 0-3 9661070-10 1998 Although FSK alone had little effect, it enhanced induction of PGHS-2 mRNA by IL-1. Colforsin 9-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 63-69 9661070-10 1998 Although FSK alone had little effect, it enhanced induction of PGHS-2 mRNA by IL-1. Colforsin 9-12 interleukin 1 alpha Homo sapiens 78-82 9625880-15 1998 It is concluded that an action on basolateral cAMP-sensitive K+ channels is an important determinant of the maintained responses to forskolin in nasal and colonic epithelia, in addition to the effects on the cystic fibrosis transmembrane conductance regulator (CFTR) in the apical membrane. Colforsin 132-141 cystic fibrosis transmembrane conductance regulator Mus musculus 261-265 9658398-5 1998 In serum-free cultures of rat granulosa cells, cyclin D2 mRNA was rapidly elevated in response to FSH, forskolin, and estradiol, indicating that estradiol as well as cAMP can act directly and independently to increase cyclin D2 expression. Colforsin 103-112 cyclin D2 Rattus norvegicus 47-56 9920534-7 1998 Parallel studies on the inhibition of forskolin-stimulated adenylyl cyclase activity in hS-HT1A x CHO cells revealed that agonist potencies were generally similar between the two functional assays and were in good agreement with the estimated 5-HT1A receptor binding affinities. Colforsin 38-47 5-hydroxytryptamine receptor 1A Homo sapiens 243-258 9663564-8 1998 Co-incubation of LPS with agents directly raising cAMP-levels like forskolin or dibutyryl cAMP yielded even stronger IL-6 induction. Colforsin 67-76 interleukin 6 Rattus norvegicus 117-121 9594016-3 1998 As determined by noise analysis of multi channel patches, DM- or CsA-activated CFTR displayed gating kinetics comparable to those of forskolin-activated CFTR. Colforsin 133-142 cystic fibrosis transmembrane conductance regulator Mus musculus 153-157 9594016-5 1998 CFTR-mediated currents were, on average, 6.1 times larger when cells were stimulated by forskolin during PP2B block compared to stimulation by forskolin alone. Colforsin 88-97 cystic fibrosis transmembrane conductance regulator Mus musculus 0-4 9594016-5 1998 CFTR-mediated currents were, on average, 6.1 times larger when cells were stimulated by forskolin during PP2B block compared to stimulation by forskolin alone. Colforsin 143-152 cystic fibrosis transmembrane conductance regulator Mus musculus 0-4 9635891-8 1998 Unexpectedly, the effect of APB could not be mimicked by application of Sp-adenosine 3",5"-cyclic monophosphothioate triethylamine (Sp-cAMPS, 100-200 microM), a membrane-permeable analog of cyclic AMP (cAMP), or by pretreatment with forskolin (25 microM), an activator of adenylyl cyclase. Colforsin 233-242 arginyl aminopeptidase Rattus norvegicus 28-31 9642127-7 1998 To elucidate whether the OPG mRNA levels are regulated via the proteinkinase A and/or the proteinkinase C pathways we stimulated cells with either forskolin (FSK) or phorbolic ester (PDbu) respectively. Colforsin 147-156 TNF receptor superfamily member 11b Homo sapiens 25-28 9642127-8 1998 FSK (10 microM) decreased OPG mRNA levels to 50 % of control, whereas PE (10 nM) upregulated the mRNA levels to 250 % of control. Colforsin 0-3 TNF receptor superfamily member 11b Homo sapiens 26-29 9632723-2 1998 Using representational difference analysis, we have identified a previously undiscovered cDNA, KID-1 (kinase induced by depolarization), that is induced by membrane depolarization or forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. Colforsin 183-192 Pim-3 proto-oncogene, serine/threonine kinase Rattus norvegicus 95-134 9609742-1 1998 Exposure of cultured human umbilical vein endothelial cells to the cAMP agonists theophylline and forskolin decreased constitutive isometric tension of a confluent monolayer inoculated on a collagen membrane, but it did not prevent increased tension in cells exposed to thrombin. Colforsin 98-107 coagulation factor II, thrombin Homo sapiens 270-278 9618556-5 1998 We find that SNAP-25 cleavage also perturbs PKA-dependent modulation of secretion; facilitation of ruthenium red-evoked neurotransmitter release by the adenylyl cyclase activator forskolin is blocked completely after Botulinum toxin A action. Colforsin 179-188 synaptosome associated protein 25 Homo sapiens 13-20 9618556-6 1998 Together with our observation that forskolin modifies the Ca2+ to neurotransmitter release relationship, our results suggest that SNAP-25 acts as a functional linker between Ca2+ detection and fusion and that PKA modulates an early step in the secretory machinery related to calcium sensing to facilitate synaptic transmission. Colforsin 35-44 synaptosome associated protein 25 Homo sapiens 130-137 9871775-3 1998 Studies of inhibition of the forskolin-stimulated c-AMP formation mediated by the human 5HT1B receptor show that hetero-bivalent ligands [combining an agonist (5HT) with an antagonist (1-NP)] behave as partial agonists while the intrinsic activity of bivalent antagonists (combining two 1-NP residues) was found to be spacer dependent. Colforsin 29-38 5-hydroxytryptamine receptor 1B Homo sapiens 88-93 9623596-5 1998 In this study, cultured term human placental and chorionic trophoblasts were used to examine the regulation of 11beta-HSD1 and 11beta-HSD2 activities and mRNA expression by progesterone, estrogen, and activators of adenylate cyclase (forskolin) and protein kinase C (phorbol 12-myristate 13-acetate, PMA). Colforsin 234-243 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 111-138 9623596-13 1998 Activation of adenylate cyclase by forskolin (100 microM) up-regulated both 11beta-HSD2 activity and mRNA expression; there was no effect of PMA (1 microM) on 11beta-HSD2. Colforsin 35-44 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 76-87 10984315-3 1998 After 72 h incubation, forskolin and 8-(4-chlorophenylthio)-cAMP (CPT-cAMP) both increased IGFBP-6 protein levels in conditioned media to maximum levels of 231 +/- 40 and 275 +/- 30%, respectively. Colforsin 23-32 insulin-like growth factor binding protein 6 Rattus norvegicus 91-98 9636995-11 1998 Pre-treatments with forskolin or cyclic AMP analogues diminished in the insulin-, EGF- and insulin plus EGF-dependent activation of MAPK in rat hepatocytes without effecting phosphorylation of receptors or MAPK. Colforsin 20-29 epidermal growth factor Rattus norvegicus 72-107 10984315-4 1998 Incubation with forskolin resulted in a small, transient rise in IGFBP-6 mRNA levels which was insufficient to account for the increased protein levels. Colforsin 16-25 insulin-like growth factor binding protein 6 Rattus norvegicus 65-72 10984315-7 1998 Co-incubation of forskolin with dexamethasone (which decreases IGFBP-6 protein and mRNA) demonstrated that the effects of the latter were dominant. Colforsin 17-26 insulin-like growth factor binding protein 6 Rattus norvegicus 63-70 9618428-4 1998 In Chinese hamster ovary cells expressing human mt1 or MT2 receptors, both melatonin and GR196429 dose-dependently inhibited forskolin-stimulated cAMP accumulation. Colforsin 125-134 metallothionein 1I, pseudogene Homo sapiens 48-51 9616219-11 1998 Further, the ACTH response to potassium and to forskolin was markedly blunted by the CRH antiserum as well as by the CRH antagonist, alpha-helical CRH(9-41). Colforsin 47-56 corticotropin releasing hormone Rattus norvegicus 85-88 9616219-11 1998 Further, the ACTH response to potassium and to forskolin was markedly blunted by the CRH antiserum as well as by the CRH antagonist, alpha-helical CRH(9-41). Colforsin 47-56 corticotropin releasing hormone Rattus norvegicus 117-120 9616219-11 1998 Further, the ACTH response to potassium and to forskolin was markedly blunted by the CRH antiserum as well as by the CRH antagonist, alpha-helical CRH(9-41). Colforsin 47-56 corticotropin releasing hormone Rattus norvegicus 117-120 9626154-11 1998 In samples from both sexes, coincubation with 1 mumol/L estrone or progesterone had no effect, whereas 1 mumol/L forskolin significantly (P < 0.05) reduced leptin release. Colforsin 113-122 leptin Homo sapiens 159-165 9626154-12 1998 In conclusion, leptin secretion from omental adipose tissue in vitro 1) is significantly higher in samples from women than in samples from men, 2) is stimulated by dexamethasone and estradiol in women but not in men, 3) is not modified by progesterone or estrone in both sexes, and 4) is inhibited by forskolin in both genders. Colforsin 301-310 leptin Homo sapiens 15-21 9618428-4 1998 In Chinese hamster ovary cells expressing human mt1 or MT2 receptors, both melatonin and GR196429 dose-dependently inhibited forskolin-stimulated cAMP accumulation. Colforsin 125-134 metallothionein 2A Homo sapiens 55-58 9669489-5 1998 However, in recombinant chinese hamster ovary cells expressing the human nociceptin receptor, we find that the pseudopeptide is a potent (IC50 = 7.5 nM) and fully efficacious inhibitor of forskolin-induced accumulation of cAMP, thus behaving as a pure "agonist" rather than an antagonist of the receptor. Colforsin 188-197 opioid related nociceptin receptor 1 Homo sapiens 73-92 9628819-5 1998 Functional studies following transient transfection of urocortin reporter plasmids in PC12 cells revealed that the urocortin promoter is controlled by both positive and negative elements; the CRE is important for basal activity as well as responsiveness to forskolin stimulation. Colforsin 257-266 urocortin Rattus norvegicus 115-124 9683023-7 1998 Furthermore, c-Myc levels decreased following forskolin treatment, while the histamine H2 receptor agonist dimaprit had no effect. Colforsin 46-55 MYC proto-oncogene, bHLH transcription factor Homo sapiens 13-18 9610389-6 1998 Expression of p105/p130 in quiescent SMC and growth-stimulated SMC (respectively, in serum-free and serum or PDGF-BB containing culture conditions) was increased by forskolin and 8-Br-cyclic GMP, both anti-mitogenic substances, but was unaffected by phorbol ester, calcium ionophores, or calcium antagonists. Colforsin 165-174 cadherin 13 Homo sapiens 14-18 9610389-6 1998 Expression of p105/p130 in quiescent SMC and growth-stimulated SMC (respectively, in serum-free and serum or PDGF-BB containing culture conditions) was increased by forskolin and 8-Br-cyclic GMP, both anti-mitogenic substances, but was unaffected by phorbol ester, calcium ionophores, or calcium antagonists. Colforsin 165-174 nucleolar and coiled-body phosphoprotein 1 Homo sapiens 19-23 9619855-5 1998 The cyclic AMP inducer, forskolin, and the activator of protein kinase C, phorbol 12-myristate 13-acetate, also stimulated the production of Il-11. Colforsin 24-33 interleukin 11 Homo sapiens 141-146 9669502-2 1998 In this study, the activity of these peptides at each of the cloned neuropeptide Y receptor subtypes is determined in radioligand binding assays and in functional assays (inhibition of forskolin-stimulated cAMP formation). Colforsin 185-194 neuropeptide Y Homo sapiens 68-82 9580572-6 1998 Interestingly, prolonged exposure to forskolin (12 hr) induced a clear decrease of CFTR-mRNA levels in T84 cells, but an increase of CFTR-mRNA levels in HT-29 cells, thus demonstrating different behaviour of CFTR gene regulation in different epithelial cells in response to intracellular cAMP. Colforsin 37-46 CF transmembrane conductance regulator Homo sapiens 83-87 9578554-5 1998 Galanin inhibited forskolin-stimulated cAMP production in GalR1/CHO cells by 70% and in GalR2/CHO cells by 30%, suggesting a strong coupling of GalR1 to Gi and a more modest coupling between GalR2 and Gi. Colforsin 18-27 Galanin receptor type 1 Cricetulus griseus 144-149 9578554-5 1998 Galanin inhibited forskolin-stimulated cAMP production in GalR1/CHO cells by 70% and in GalR2/CHO cells by 30%, suggesting a strong coupling of GalR1 to Gi and a more modest coupling between GalR2 and Gi. Colforsin 18-27 galanin receptor type 2 Cricetulus griseus 191-196 9578554-5 1998 Galanin inhibited forskolin-stimulated cAMP production in GalR1/CHO cells by 70% and in GalR2/CHO cells by 30%, suggesting a strong coupling of GalR1 to Gi and a more modest coupling between GalR2 and Gi. Colforsin 18-27 galanin peptides Cricetulus griseus 0-7 9578554-5 1998 Galanin inhibited forskolin-stimulated cAMP production in GalR1/CHO cells by 70% and in GalR2/CHO cells by 30%, suggesting a strong coupling of GalR1 to Gi and a more modest coupling between GalR2 and Gi. Colforsin 18-27 Galanin receptor type 1 Cricetulus griseus 58-63 9580572-6 1998 Interestingly, prolonged exposure to forskolin (12 hr) induced a clear decrease of CFTR-mRNA levels in T84 cells, but an increase of CFTR-mRNA levels in HT-29 cells, thus demonstrating different behaviour of CFTR gene regulation in different epithelial cells in response to intracellular cAMP. Colforsin 37-46 CF transmembrane conductance regulator Homo sapiens 133-137 9580572-6 1998 Interestingly, prolonged exposure to forskolin (12 hr) induced a clear decrease of CFTR-mRNA levels in T84 cells, but an increase of CFTR-mRNA levels in HT-29 cells, thus demonstrating different behaviour of CFTR gene regulation in different epithelial cells in response to intracellular cAMP. Colforsin 37-46 CF transmembrane conductance regulator Homo sapiens 133-137 9652344-1 1998 We have previously reported that the transfected Gi/Go protein-coupled human adenosine A1 receptor (expressed at 200 fmol/mg of protein) and the endogenous 5-HT1B receptor (not detectable using radioligand binding) suppress forskolin-stimulated cyclic AMP accumulation and stimulate increases in [Ca2+]i in Chinese hamster ovary cells (CHO). Colforsin 224-233 5-hydroxytryptamine receptor 1B Homo sapiens 156-162 9612222-1 1998 Forskolin, which elevates cAMP levels, and sodium nitroprusside (SNP) and nicorandil, which elevate cGMP levels, increased, by two- to threefold, the frequency of subcellular Ca2+ release ("Ca2+ sparks") through ryanodine-sensitive Ca2+ release (RyR) channels in the sarcoplasmic reticulum (SR) of myocytes isolated from cerebral and coronary arteries of rats. Colforsin 0-9 ryanodine receptor 2 Rattus norvegicus 212-244 9576105-5 1998 Incubation of cultured VSMCs with a PDE4-selective inhibitor, Ro 20-1724, markedly potentiated both the antimigratory effect and the increase in cAMP caused by forskolin. Colforsin 160-169 phosphodiesterase 4A Homo sapiens 36-40 9572838-6 1998 PTH/PTHrP receptor phosphorylation in ROS 17/2.8, COS-7, and LLCPK-1 cells was also stimulated with forskolin and phorbol myristate acetate (PMA). Colforsin 100-109 parathyroid hormone Rattus norvegicus 0-3 9572838-6 1998 PTH/PTHrP receptor phosphorylation in ROS 17/2.8, COS-7, and LLCPK-1 cells was also stimulated with forskolin and phorbol myristate acetate (PMA). Colforsin 100-109 parathyroid hormone-like hormone Rattus norvegicus 4-9 9612222-1 1998 Forskolin, which elevates cAMP levels, and sodium nitroprusside (SNP) and nicorandil, which elevate cGMP levels, increased, by two- to threefold, the frequency of subcellular Ca2+ release ("Ca2+ sparks") through ryanodine-sensitive Ca2+ release (RyR) channels in the sarcoplasmic reticulum (SR) of myocytes isolated from cerebral and coronary arteries of rats. Colforsin 0-9 ryanodine receptor 2 Rattus norvegicus 246-249 9625375-3 1998 METHODS: In cultured rat granulosa cells, the effect of tyrphostin on LH-, dibutyryl cyclic AMP ((Bu)2cAMP)- or forskolin-stimulated tissue type plasminogen activator (tPA) activities was examined by using a fibrin autography technique. Colforsin 112-121 plasminogen activator, tissue type Rattus norvegicus 133-166 9629248-8 1998 This synergy involved cAMP-dependent pathways, as forskolin action was also potentiated by LIF. Colforsin 50-59 leukemia inhibitory factor Mus musculus 91-94 9607407-4 1998 Angiotensin II produced inhibition of forskolin-stimulated cAMP accumulation at 10(-13) - 10(-10) M followed by a stimulation in basal cAMP levels at 10(-7) - 10(-5) M. Pretreatment of proximal tubules with losartan (1nM) antagonized both the stimulatory and inhibitory effects of angiotensin II on cAMP accumulation. Colforsin 38-47 angiotensinogen Homo sapiens 0-14 9607407-4 1998 Angiotensin II produced inhibition of forskolin-stimulated cAMP accumulation at 10(-13) - 10(-10) M followed by a stimulation in basal cAMP levels at 10(-7) - 10(-5) M. Pretreatment of proximal tubules with losartan (1nM) antagonized both the stimulatory and inhibitory effects of angiotensin II on cAMP accumulation. Colforsin 38-47 angiotensinogen Homo sapiens 281-295 9589661-4 1998 Forskolin (10 mumol/L) treatment caused a progressive increase in CYP21 mRNA levels (maximum, 4-fold; P < 0.05) over 36 h of treatment, whereas angiotensin II (AII; 10 nmol/L) produced a smaller, biphasic rise (maximum, 1.8-fold at 12 h; P < 0.05). Colforsin 0-9 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 66-71 9628798-10 1998 Mucin-like glycoprotein secretion was stimulated in a dose-dependent manner following elevation of cAMP levels by exposure to either forskolin, dibutyryl cAMP or 3-isobutyl-1-methylxanthine. Colforsin 133-142 cathelicidin antimicrobial peptide Rattus norvegicus 99-103 9556631-2 1998 Incorporation of 32P into telokin, a smooth muscle-specific, 17-18-kDa, acidic (pI 4.2-4.4) protein, was increased by forskolin (20 microM) in intact rabbit ileum smooth muscle (ileum) and by 8-bromo-cyclic GMP (100 microM) in alpha-toxin-permeabilized ileum. Colforsin 118-127 myosin light chain kinase, smooth muscle Oryctolagus cuniculus 26-33 9556631-7 1998 Forskolin (20 microM) also increased phosphorylation of telokin in intact ileum. Colforsin 0-9 myosin light chain kinase, smooth muscle Oryctolagus cuniculus 56-63 9589661-11 1998 Inhibition of protein synthesis with cycloheximide blocked induction of CYP21 as well as type II 3 beta-hydroxysteroid dehydrogenase (3 beta HSDII) mRNA expression in response to AII, forskolin, and dibutyryl cAMP, but had no effect on 17 alpha-hydroxylase cytochrome P450 (CYP17) or cholesterol side-chain cleavage cytochrome P450 (CYP11A) mRNA. Colforsin 184-193 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 72-77 9533945-4 1998 Pretreatment of cells with inhibitors of MEK (PD98059), Raf-1 (forskolin), and PKC (chelerythrine) each reduced H2O2-induced ERK activity. Colforsin 63-72 RAF1 Bos taurus 56-61 9547227-7 1998 High concentrations of forskolin induced mossy fiber LTP to comparable levels in wild-type and AC1 mutant mice, indicating that signaling components downstream from the adenylyl cyclase, including PKA, ion channels, and secretory machinery, were not affected by disruption of the AC1 gene. Colforsin 23-32 adenylate cyclase 1 Mus musculus 95-98 9659296-12 1998 Forskolin, which increases cAMP, increased IGFBP-3 protein and mRNA levels. Colforsin 0-9 insulin like growth factor binding protein 3 Bos taurus 43-50 9659296-14 1998 In contrast, forskolin decreased IGFBP-6 mRNA relative to controls, but had no effect on IGFBP-2. Colforsin 13-22 insulin like growth factor binding protein 6 Bos taurus 33-40 9659296-15 1998 The decrease in IGFBP-6 was less marked when cells were treated with a combination of IGF-I and forskolin. Colforsin 96-105 insulin like growth factor binding protein 6 Bos taurus 16-23 9614644-6 1998 Forskolin treatment increased the basal production of DHEAS ten-fold. Colforsin 0-9 sulfotransferase family 2A member 1 Homo sapiens 54-59 9614644-7 1998 Estradiol also increased the forskolin stimulation of DHEAS production two-fold. Colforsin 29-38 sulfotransferase family 2A member 1 Homo sapiens 54-59 9553093-8 1998 alpha2A-Adrenoreceptor agonists could stimulate both p44 mitogen-activated protein kinase and p70 S6 kinase and inhibit forskolin-amplified adenylyl cyclase activity in untreated alpha2A-adrenoreceptor-C351G Gi1alpha fusion protein-expressing cells, but these signals were abolished following pertussis toxin treatment. Colforsin 120-129 adrenoceptor alpha 2A Homo sapiens 0-22 9553093-8 1998 alpha2A-Adrenoreceptor agonists could stimulate both p44 mitogen-activated protein kinase and p70 S6 kinase and inhibit forskolin-amplified adenylyl cyclase activity in untreated alpha2A-adrenoreceptor-C351G Gi1alpha fusion protein-expressing cells, but these signals were abolished following pertussis toxin treatment. Colforsin 120-129 adrenoceptor alpha 2A Homo sapiens 179-201 9545284-5 1998 In extracts prepared from human medullary thymocytes treated with forskolin and ionomycin, these composite sites bind endogenously expressed ICER either singly or in complexes. Colforsin 66-75 cAMP responsive element modulator Homo sapiens 141-145 9628464-9 1998 The LPS-induced IL-6 production from macrophages was also potentiated by forskolin 5 microM, an activator of adenylate cyclase. Colforsin 73-82 toll-like receptor 4 Mus musculus 4-7 9628464-9 1998 The LPS-induced IL-6 production from macrophages was also potentiated by forskolin 5 microM, an activator of adenylate cyclase. Colforsin 73-82 interleukin 6 Mus musculus 16-20 9575827-0 1998 The cAMP-response element mediates induction of secretogranin II by CHX and FSK in GH4C1 cells. Colforsin 76-79 secretogranin II Rattus norvegicus 48-64 9575854-3 1998 Under control conditions, forskolin increased Js-->m and Isc (+1.7 and +3.5, respectively) across the CFTR(+) but not CFTR(-) duodenum. Colforsin 26-35 cystic fibrosis transmembrane conductance regulator Mus musculus 105-109 9575827-2 1998 We have defined elements in the SgII promoter that mediate regulation by cycloheximide (CHX) and forskolin (FSK) and characterized the nuclear proteins that interact with them. Colforsin 97-106 secretogranin II Rattus norvegicus 32-36 9606178-12 1998 CONCLUSIONS: The results presented here support a model in which okadaic acid, forskolin, and isoproterenol achieve their synergistic effects with serotonin through phosphorylation of DARPP-32 and inhibitor-1, inhibition of protein phosphatase-1, and a reduction of dephosphorylation of Na+,K(+)-ATPase at a protein kinase C phosphorylation site. Colforsin 79-88 protein phosphatase 1 regulatory inhibitor subunit 1B Homo sapiens 184-192 9575827-2 1998 We have defined elements in the SgII promoter that mediate regulation by cycloheximide (CHX) and forskolin (FSK) and characterized the nuclear proteins that interact with them. Colforsin 108-111 secretogranin II Rattus norvegicus 32-36 9528997-8 1998 The receptor-independent secretagogues beta phorbol myristate acetate and forskolin dose dependently increased the secretion of GLP-1; effects inhibited by staurosporine and H8 respectively. Colforsin 74-83 glucagon Canis lupus familiaris 128-133 9543165-9 1998 In primary cultures of human fetal adrenal cortical cells, ACTH (1 nmol/L) and forskolin (10 micromol/L) increased the abundance of messenger ribonucleic acid transcripts encoding VEGF, as assessed by Northern and slot blot analyses. Colforsin 79-88 vascular endothelial growth factor A Homo sapiens 180-184 9543165-10 1998 The stimulatory effect of ACTH and forskolin on VEGF gene expression occurred within 2 h of agonist exposure and persisted for at least 24 h. ACTH and forskolin also increased VEGF protein secretion by fetal adrenal cortical cells, as assessed by enzyme-linked immunosorbent assay for VEGF in fetal adrenal cortical cell-conditioned medium. Colforsin 35-44 vascular endothelial growth factor A Homo sapiens 48-52 9543165-10 1998 The stimulatory effect of ACTH and forskolin on VEGF gene expression occurred within 2 h of agonist exposure and persisted for at least 24 h. ACTH and forskolin also increased VEGF protein secretion by fetal adrenal cortical cells, as assessed by enzyme-linked immunosorbent assay for VEGF in fetal adrenal cortical cell-conditioned medium. Colforsin 35-44 proopiomelanocortin Homo sapiens 142-146 9543165-10 1998 The stimulatory effect of ACTH and forskolin on VEGF gene expression occurred within 2 h of agonist exposure and persisted for at least 24 h. ACTH and forskolin also increased VEGF protein secretion by fetal adrenal cortical cells, as assessed by enzyme-linked immunosorbent assay for VEGF in fetal adrenal cortical cell-conditioned medium. Colforsin 35-44 vascular endothelial growth factor A Homo sapiens 176-180 9543165-10 1998 The stimulatory effect of ACTH and forskolin on VEGF gene expression occurred within 2 h of agonist exposure and persisted for at least 24 h. ACTH and forskolin also increased VEGF protein secretion by fetal adrenal cortical cells, as assessed by enzyme-linked immunosorbent assay for VEGF in fetal adrenal cortical cell-conditioned medium. Colforsin 35-44 vascular endothelial growth factor A Homo sapiens 176-180 9543165-10 1998 The stimulatory effect of ACTH and forskolin on VEGF gene expression occurred within 2 h of agonist exposure and persisted for at least 24 h. ACTH and forskolin also increased VEGF protein secretion by fetal adrenal cortical cells, as assessed by enzyme-linked immunosorbent assay for VEGF in fetal adrenal cortical cell-conditioned medium. Colforsin 151-160 proopiomelanocortin Homo sapiens 26-30 9543165-10 1998 The stimulatory effect of ACTH and forskolin on VEGF gene expression occurred within 2 h of agonist exposure and persisted for at least 24 h. ACTH and forskolin also increased VEGF protein secretion by fetal adrenal cortical cells, as assessed by enzyme-linked immunosorbent assay for VEGF in fetal adrenal cortical cell-conditioned medium. Colforsin 151-160 vascular endothelial growth factor A Homo sapiens 48-52 9543165-10 1998 The stimulatory effect of ACTH and forskolin on VEGF gene expression occurred within 2 h of agonist exposure and persisted for at least 24 h. ACTH and forskolin also increased VEGF protein secretion by fetal adrenal cortical cells, as assessed by enzyme-linked immunosorbent assay for VEGF in fetal adrenal cortical cell-conditioned medium. Colforsin 151-160 vascular endothelial growth factor A Homo sapiens 176-180 9543165-10 1998 The stimulatory effect of ACTH and forskolin on VEGF gene expression occurred within 2 h of agonist exposure and persisted for at least 24 h. ACTH and forskolin also increased VEGF protein secretion by fetal adrenal cortical cells, as assessed by enzyme-linked immunosorbent assay for VEGF in fetal adrenal cortical cell-conditioned medium. Colforsin 151-160 vascular endothelial growth factor A Homo sapiens 176-180 9543165-11 1998 A significant (P < 0.05) increase in VEGF secretion was detected as early as 8 h after ACTH or forskolin treatment. Colforsin 98-107 vascular endothelial growth factor A Homo sapiens 40-44 9543165-12 1998 By 24 h after the addition of ACTH or forskolin, VEGF secreted from isolated human fetal adrenal cells was increased 5- to 6-fold. Colforsin 38-47 vascular endothelial growth factor A Homo sapiens 49-53 9544985-3 1998 Temporal differences in c-fos, junB, and inducible cAMP early repressor (ICER) steady-state mRNA levels were observed after forskolin exposure. Colforsin 124-133 FBJ osteosarcoma oncogene Mus musculus 24-29 9544985-3 1998 Temporal differences in c-fos, junB, and inducible cAMP early repressor (ICER) steady-state mRNA levels were observed after forskolin exposure. Colforsin 124-133 cAMP responsive element modulator Mus musculus 41-71 9544985-3 1998 Temporal differences in c-fos, junB, and inducible cAMP early repressor (ICER) steady-state mRNA levels were observed after forskolin exposure. Colforsin 124-133 cAMP responsive element modulator Mus musculus 73-77 9566579-5 1998 The levels of [3H]forskolin binding were elevated (28-67%) in cortex, thalamus, dentate gyrus, hippocampal CA3 and cerebellum of the pentobarbital withdrawal animals, while these changes were not observed in tolerant rats. Colforsin 18-27 carbonic anhydrase 3 Rattus norvegicus 107-110 9575854-4 1998 Both the forskolin-stimulated delta Js-->m and delta Isc were abolished by the CFTR channel blocker 5-nitro-2-(3-phenylpropylamino)benzoate, whereas inhibition of luminal Cl-/HCO3- exchange by luminal Cl- removal or DIDS reduced the Js-->m by approximately 18% without a consistent effect on the delta Isc. Colforsin 9-18 cystic fibrosis transmembrane conductance regulator Mus musculus 82-86 9575854-6 1998 When carbonic anhydrase-dependent HCO3- secretion was isolated by using a CO2-gassed, HCO3(-)-free Ringer bath, forskolin stimulated the Js-->m and Isc (+0.7 and +2.0, respectively) across CFTR(+) but not CFTR(-) duodenum. Colforsin 112-121 cystic fibrosis transmembrane conductance regulator Mus musculus 192-196 9575854-6 1998 When carbonic anhydrase-dependent HCO3- secretion was isolated by using a CO2-gassed, HCO3(-)-free Ringer bath, forskolin stimulated the Js-->m and Isc (+0.7 and +2.0, respectively) across CFTR(+) but not CFTR(-) duodenum. Colforsin 112-121 cystic fibrosis transmembrane conductance regulator Mus musculus 208-212 9614355-9 1998 Galanin also dose-dependently inhibited forskolin-induced GLP-1 secretion (74% of inhibition with 100 nM galanin), but not TPA-stimulated hormone release. Colforsin 40-49 glucagon Rattus norvegicus 58-63 9630398-6 1998 Application of somatostatin-14 and -28 to human embryonic kidney cells expressing the recombinant receptor resulted in the inhibition of forskolin-stimulated adenylyl cyclase with comparable EC50 values. Colforsin 137-146 somatostatin Homo sapiens 15-38 9606178-11 1998 Forskolin and isoproterenol also stimulate the phosphorylation of DARPP-32 and protein phosphatase inhibitor-1, which in their phosphorylated form are potent inhibitors of protein phosphatase-1. Colforsin 0-9 protein phosphatase 1 regulatory inhibitor subunit 1B Homo sapiens 66-74 9606178-11 1998 Forskolin and isoproterenol also stimulate the phosphorylation of DARPP-32 and protein phosphatase inhibitor-1, which in their phosphorylated form are potent inhibitors of protein phosphatase-1. Colforsin 0-9 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 79-110 9606178-12 1998 CONCLUSIONS: The results presented here support a model in which okadaic acid, forskolin, and isoproterenol achieve their synergistic effects with serotonin through phosphorylation of DARPP-32 and inhibitor-1, inhibition of protein phosphatase-1, and a reduction of dephosphorylation of Na+,K(+)-ATPase at a protein kinase C phosphorylation site. Colforsin 79-88 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 197-208 9569204-2 1998 Prostacyclin, isoproterenol and forskolin, which increased [cAMP]i in HUVEC, and the cell-permeant cAMP analog 8-bromo-cAMP induced dose- and time-dependent secretion of tPA and vWF. Colforsin 32-41 plasminogen activator, tissue type Homo sapiens 170-173 9654400-8 1998 Treatment of cells with forskolin and EGF causes similar inhibition of MAP kinase phosphorylation as observed with PGE2 and EGF. Colforsin 24-33 pro-epidermal growth factor Mesocricetus auratus 115-127 9569204-2 1998 Prostacyclin, isoproterenol and forskolin, which increased [cAMP]i in HUVEC, and the cell-permeant cAMP analog 8-bromo-cAMP induced dose- and time-dependent secretion of tPA and vWF. Colforsin 32-41 von Willebrand factor Homo sapiens 178-181 9555020-3 1998 Treatment of mesangial cells with IL-1beta or forskolin for 24 h induces group II PLA2 activity secreted into cell culture supernatants by about 15-fold and 11-fold, respectively. Colforsin 46-55 phospholipase A2 group IB Homo sapiens 82-86 9555020-6 1998 Basic fibroblast growth factor (bFGF) virtually does not inhibit IL-1beta-stimulated group II PLA2 activity, but markedly inhibits forskolin-induced expression of group II PLA2 activity. Colforsin 131-140 fibroblast growth factor 2 Rattus norvegicus 0-30 9554975-3 1998 Cholesterol efflux and HDL3 binding were stimulated by the cAMP analogue CPT-cAMP, the adenylate cyclase activator forskolin, and by iloprost and prostaglandin E1 (PGE1) (which elevate cAMP via receptor-mediated processes). Colforsin 115-124 HDL3 Homo sapiens 23-27 9555020-6 1998 Basic fibroblast growth factor (bFGF) virtually does not inhibit IL-1beta-stimulated group II PLA2 activity, but markedly inhibits forskolin-induced expression of group II PLA2 activity. Colforsin 131-140 fibroblast growth factor 2 Rattus norvegicus 32-36 9555020-6 1998 Basic fibroblast growth factor (bFGF) virtually does not inhibit IL-1beta-stimulated group II PLA2 activity, but markedly inhibits forskolin-induced expression of group II PLA2 activity. Colforsin 131-140 phospholipase A2 group IB Homo sapiens 172-176 9592034-11 1998 Forskolin-induced bone resorption was, as with parathyroid hormone but in contrast to ionophore-induced bone resorption, not abolished by indomethacin (1 microM). Colforsin 0-9 parathyroid hormone Mus musculus 47-66 9521705-0 1998 Forskolin-induced dephosphorylation of the androgen receptor impairs ligand binding. Colforsin 0-9 androgen receptor Homo sapiens 43-60 9514865-11 1998 The gene expression for ADM in glomerular epithelial cells was down-regulated when incubated with increasing concentration of TNF-alpha, forskolin or FBS. Colforsin 137-146 adrenomedullin Homo sapiens 24-27 9521705-1 1998 When androgen receptor containing cells are cultured in the presence of the PKA stimulator forskolin, a rapid dephosphorylation of the androgen receptor occurs resulting in a decrease in the amount of 112 kDa androgen receptor isoform and an increase in 110 kDa androgen receptor isoform on SDS-PAGE. Colforsin 91-100 androgen receptor Homo sapiens 5-22 9521705-1 1998 When androgen receptor containing cells are cultured in the presence of the PKA stimulator forskolin, a rapid dephosphorylation of the androgen receptor occurs resulting in a decrease in the amount of 112 kDa androgen receptor isoform and an increase in 110 kDa androgen receptor isoform on SDS-PAGE. Colforsin 91-100 androgen receptor Homo sapiens 135-152 9521705-1 1998 When androgen receptor containing cells are cultured in the presence of the PKA stimulator forskolin, a rapid dephosphorylation of the androgen receptor occurs resulting in a decrease in the amount of 112 kDa androgen receptor isoform and an increase in 110 kDa androgen receptor isoform on SDS-PAGE. Colforsin 91-100 androgen receptor Homo sapiens 135-152 9482792-7 1998 L-Glutamate or agonists of class II receptors decreased NE- or forskolin-dependent increase of cAMP and serotonin-N-acetyltransferase activities to similar extents. Colforsin 63-72 aralkylamine N-acetyltransferase Rattus norvegicus 104-133 9521705-1 1998 When androgen receptor containing cells are cultured in the presence of the PKA stimulator forskolin, a rapid dephosphorylation of the androgen receptor occurs resulting in a decrease in the amount of 112 kDa androgen receptor isoform and an increase in 110 kDa androgen receptor isoform on SDS-PAGE. Colforsin 91-100 androgen receptor Homo sapiens 135-152 9521705-2 1998 To establish which amino acid residues in the androgen receptor were phosphorylated in control and forskolin-treated cells, trypsin-digested androgen receptors were subjected to RP-HPLC analysis and subsequently to Edman degradation. Colforsin 99-108 androgen receptor Homo sapiens 46-63 9521705-4 1998 When the dephosphorylated androgen receptor was analyzed for its transcription activation capacity, it was observed that androgen-induced transcriptional regulation of two endogenous genes (PSA) and beta 1-subunit of Na,K-ATPase), in cells cultured in the presence of forskolin, was inhibited as compared to the control situation. Colforsin 268-277 androgen receptor Homo sapiens 26-43 9521705-4 1998 When the dephosphorylated androgen receptor was analyzed for its transcription activation capacity, it was observed that androgen-induced transcriptional regulation of two endogenous genes (PSA) and beta 1-subunit of Na,K-ATPase), in cells cultured in the presence of forskolin, was inhibited as compared to the control situation. Colforsin 268-277 ATPase Na+/K+ transporting subunit beta 1 Homo sapiens 199-228 9685226-2 1998 Both calcitonin and forskolin caused a 5-6-fold increase in transcription initiated from both the P1 and P3 promoters, but with no observed effect on the P2 promoter. Colforsin 20-29 crystallin gamma F, pseudogene Homo sapiens 98-107 9492065-5 1998 T3 also reduced PGE1-induced activation of protein kinase A. T3 inhibited the IL-6 synthesis induced by cholera toxin, an activator of Gs, or forskolin, which directly activates adenylate cyclase. Colforsin 142-151 interleukin 6 Mus musculus 78-82 9494083-4 1998 cAMP, forskolin and glucagon (half-maximal effect at 10 nM) mimicked inhibition of the thapsigargin-stimulated Ca2+o-induced increase in [Ca2+]c by GTP[S], but had little effect on thapsigargin-induced release of Ca2+ from intracellular stores. Colforsin 6-15 carbonic anhydrase 2 Rattus norvegicus 111-114 9494083-4 1998 cAMP, forskolin and glucagon (half-maximal effect at 10 nM) mimicked inhibition of the thapsigargin-stimulated Ca2+o-induced increase in [Ca2+]c by GTP[S], but had little effect on thapsigargin-induced release of Ca2+ from intracellular stores. Colforsin 6-15 carbonic anhydrase 2 Rattus norvegicus 138-141 9494083-4 1998 cAMP, forskolin and glucagon (half-maximal effect at 10 nM) mimicked inhibition of the thapsigargin-stimulated Ca2+o-induced increase in [Ca2+]c by GTP[S], but had little effect on thapsigargin-induced release of Ca2+ from intracellular stores. Colforsin 6-15 carbonic anhydrase 2 Rattus norvegicus 138-141 9494083-6 1998 In contrast, Ruthenium Red markedly enhanced the thapsigargin-stimulated Ca2+o-induced increase in [Ca2+]c in both the presence and absence of increased cAMP (induced by forskolin and dibutyryl cAMP). Colforsin 170-179 carbonic anhydrase 2 Rattus norvegicus 73-76 9580817-3 1998 Preliminary data in three human melanoma cell lines also showed alpha-MSH and forskolin to be effective in significantly reducing TNF-alpha stimulated ICAM-1 expression over 24 h. The extent of the inhibition varied from cell line to cell line and was greatest in those cells with the highest number of alpha-MSH receptors. Colforsin 78-87 tumor necrosis factor Homo sapiens 130-139 9580817-3 1998 Preliminary data in three human melanoma cell lines also showed alpha-MSH and forskolin to be effective in significantly reducing TNF-alpha stimulated ICAM-1 expression over 24 h. The extent of the inhibition varied from cell line to cell line and was greatest in those cells with the highest number of alpha-MSH receptors. Colforsin 78-87 intercellular adhesion molecule 1 Homo sapiens 151-157 9580817-3 1998 Preliminary data in three human melanoma cell lines also showed alpha-MSH and forskolin to be effective in significantly reducing TNF-alpha stimulated ICAM-1 expression over 24 h. The extent of the inhibition varied from cell line to cell line and was greatest in those cells with the highest number of alpha-MSH receptors. Colforsin 78-87 proopiomelanocortin Homo sapiens 303-312 9519762-3 1998 We demonstrate here that the insulinotropic effect of forskolin in the GK rat is due to increased generation of cAMP and that it is associated with overexpression of adenylyl cyclase (AC)-III mRNA and gene mutations. Colforsin 54-63 adenylate cyclase 3 Rattus norvegicus 166-191 9539153-4 1998 The stable PGI2 analog iloprost, like other cAMP-raising agents (forskolin and adenosine), caused an acute dose-dependent increase in vWf release and potentiated the secretory response to thrombin. Colforsin 65-74 von Willebrand factor Homo sapiens 134-137 9539153-4 1998 The stable PGI2 analog iloprost, like other cAMP-raising agents (forskolin and adenosine), caused an acute dose-dependent increase in vWf release and potentiated the secretory response to thrombin. Colforsin 65-74 coagulation factor II, thrombin Homo sapiens 188-196 9555029-6 1998 Forskolin also increased cAMP, but did not mimic the [Ca2+]i-raising effect of AM. Colforsin 0-9 adrenomedullin Homo sapiens 26-28 9580144-4 1998 The maximum B2 receptor mRNA expression (160% above control) was observed in cells treated during 24 h with forskolin and was prevented by actinomycin D. Colforsin 108-117 bradykinin receptor B2 Rattus norvegicus 12-23 9519739-1 1998 Under Ca2+-free conditions, activation of the pancreatic beta-cell with forskolin and 12-O-tetradecanoylphorbol 13-acetate (TPA) is permissive for the augmentation of insulin release by glucose and other nutrients. Colforsin 72-81 insulin Homo sapiens 167-174 9492053-14 1998 Phosphorylated CREB was increased by forskolin treatment, an effect that was blocked by a PKA-inhibitor. Colforsin 37-46 cAMP responsive element binding protein 1 Homo sapiens 15-19 9454737-9 1998 Both Rb dephosphorylation and PARP cleavage were inhibited by forskolin plus theophylline. Colforsin 62-71 RB transcriptional corepressor 1 Homo sapiens 5-7 9501870-10 1998 Forskolin (10 microM), a cyclic adenosine monophosphate activator, also stimulated VEGF and bFGF mRNA expression. Colforsin 0-9 vascular endothelial growth factor A Rattus norvegicus 83-87 9501870-10 1998 Forskolin (10 microM), a cyclic adenosine monophosphate activator, also stimulated VEGF and bFGF mRNA expression. Colforsin 0-9 fibroblast growth factor 2 Rattus norvegicus 92-96 9501870-11 1998 However, the effects of forskolin and PGE2 on VEGF gene expression were not additive, whereas forskolin enhanced the effect of PGE2 on bFGF mRNA expression. Colforsin 24-33 vascular endothelial growth factor A Rattus norvegicus 46-50 9501870-11 1998 However, the effects of forskolin and PGE2 on VEGF gene expression were not additive, whereas forskolin enhanced the effect of PGE2 on bFGF mRNA expression. Colforsin 94-103 fibroblast growth factor 2 Rattus norvegicus 135-139 9454737-9 1998 Both Rb dephosphorylation and PARP cleavage were inhibited by forskolin plus theophylline. Colforsin 62-71 poly(ADP-ribose) polymerase 1 Homo sapiens 30-34 9462691-4 1998 Agents that elevate intracellular cAMP concentrations (dcAMP, forskolin, isoproterenol, and prostaglandin [PGE1]) increase secretion of IGFBP-4 and IGFBP-5 from L6 cells. Colforsin 62-71 insulin-like growth factor binding protein 4 Mus musculus 136-143 9506767-4 1998 Forskolin and dexamethasone at concentrations of 10 micromol/L stimulated and inhibited, respectively, CRH peptide production in squamous cell carcinoma and melanoma cells, but had no significant effect on the CRH mRNA level. Colforsin 0-9 corticotropin releasing hormone Homo sapiens 103-106 9462691-4 1998 Agents that elevate intracellular cAMP concentrations (dcAMP, forskolin, isoproterenol, and prostaglandin [PGE1]) increase secretion of IGFBP-4 and IGFBP-5 from L6 cells. Colforsin 62-71 insulin-like growth factor binding protein 5 Mus musculus 148-155 9489722-4 1998 Treatment with forskolin elicited a relatively poor mRNA induction for immediate early genes in PC12D-ATF1 RL cells, a PC12D cell line stably expressing ATF1RL, in comparison with the parental PC12D cells. Colforsin 15-24 activating transcription factor 1 Rattus norvegicus 102-106 9482713-2 1998 Previous studies have shown that genistein increased cystic fibrosis transmembrane conductance regulator (CFTR) channel activity in the presence of saturating concentrations of forskolin and calyculin A in intact cells. Colforsin 177-186 cystic fibrosis transmembrane conductance regulator Mus musculus 53-104 9482713-2 1998 Previous studies have shown that genistein increased cystic fibrosis transmembrane conductance regulator (CFTR) channel activity in the presence of saturating concentrations of forskolin and calyculin A in intact cells. Colforsin 177-186 cystic fibrosis transmembrane conductance regulator Mus musculus 106-110 9506451-9 1998 Western blot analysis of extracts from control and forskolin or dibutyryl cAMP-treated A431 and KB cells demonstrated the presence of proteins with a molecular mass identical to that corresponding to recombinant human PDE 4B. Colforsin 51-60 phosphodiesterase 4B Homo sapiens 218-224 9478958-10 1998 Also, we observed that forskolin induced transcription of the IkappaBalpha gene in a time-dependent manner and in addition up-regulated LPS-induced IkappaBalpha mRNA levels. Colforsin 23-32 NFKB inhibitor alpha Rattus norvegicus 62-74 9478958-10 1998 Also, we observed that forskolin induced transcription of the IkappaBalpha gene in a time-dependent manner and in addition up-regulated LPS-induced IkappaBalpha mRNA levels. Colforsin 23-32 NFKB inhibitor alpha Rattus norvegicus 148-160 9478958-2 1998 Agents that elevated intracellular cAMP levels (e.g. forskolin, dibutyryl cAMP, cholera toxin, and isoproterenol) markedly decreased nitrite production and iNOS protein formation by LPS-stimulated Kupffer cells. Colforsin 53-62 nitric oxide synthase 2 Rattus norvegicus 156-160 9478958-4 1998 Forskolin, the most potent inhibitor of LPS-induced nitrite formation by Kupffer cells, decreased iNOS mRNA levels in a time-dependent manner. Colforsin 0-9 nitric oxide synthase 2 Rattus norvegicus 98-102 9473304-8 1998 Forskolin and dibutyryl cAMP mimicked the suppressive effect of glucagon on aldolase B gene expression. Colforsin 0-9 aldolase, fructose-bisphosphate B Rattus norvegicus 76-86 9478958-5 1998 Time course studies indicated that forskolin was most effective at inhibiting LPS-induced nitrite formation and iNOS mRNA levels by Kupffer cells when added before LPS. Colforsin 35-44 nitric oxide synthase 2 Rattus norvegicus 112-116 9478958-7 1998 Nuclear run-on assays revealed that forskolin decreased LPS-induced transcription of the iNOS gene. Colforsin 36-45 nitric oxide synthase 2 Rattus norvegicus 89-93 9466982-12 1998 Cotransfection of expression plasmids encoding the protein kinase A inhibitor, or an inactive protein kinase A (PKA) catalytic beta subunit, inhibited both forskolin and PACAP activation of chromogranin A transcription, revealing that PACAP-induced trans-activation is highly dependent on PKA. Colforsin 156-165 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 51-67 9466982-12 1998 Cotransfection of expression plasmids encoding the protein kinase A inhibitor, or an inactive protein kinase A (PKA) catalytic beta subunit, inhibited both forskolin and PACAP activation of chromogranin A transcription, revealing that PACAP-induced trans-activation is highly dependent on PKA. Colforsin 156-165 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 94-110 9466982-12 1998 Cotransfection of expression plasmids encoding the protein kinase A inhibitor, or an inactive protein kinase A (PKA) catalytic beta subunit, inhibited both forskolin and PACAP activation of chromogranin A transcription, revealing that PACAP-induced trans-activation is highly dependent on PKA. Colforsin 156-165 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 112-115 9448281-6 1998 In parallel experiments performed on cells transfected with lacZ (control) or ACVI, [3H]forskolin binding, used to assess AC protein expression, was amplified 6-fold, while betaAR-stimulated cAMP production from these cells was increased 7-fold. Colforsin 88-97 adenylate cyclase 6 Rattus norvegicus 78-82 9512670-3 1998 Co-stimulation with serum and forskolin resulted in a more than additive increase in c-fos transcription. Colforsin 30-39 FBJ osteosarcoma oncogene Mus musculus 85-90 9512670-4 1998 Synergistic increase in c-fos promoter activity was also observed in transient transfection studies after co-stimulation with serum plus forskolin or co-transfection with c-Raf and PKA expression plasmids. Colforsin 137-146 FBJ osteosarcoma oncogene Mus musculus 24-29 9473478-3 1998 Treatment of the PC12 cells with forskolin, dibutryl cAMP, or 8-CPT-cAMP for three hours decreased RGS4 message by nearly 50%. Colforsin 33-42 regulator of G-protein signaling 4 Rattus norvegicus 99-103 9473478-6 1998 In contrast, RGS2 message is not evident in unstimulated cells but is strongly induced by one hour of treatment with forskolin. Colforsin 117-126 regulator of G-protein signaling 2 Rattus norvegicus 13-17 9486142-3 1998 Sustained [Ca2+]i elevation, induced by high KCl (25 mM) at a basal glucose concentration (2.8 mM), was substantially reduced by cAMP-increasing agents, dibutyryl cAMP (DBcAMP, 5 mM), an adenylyl cyclase activator forskolin (10 microM), and an incretin glucagon-like peptide-1-(7-36) amide (10(-9) M), as well as by glucose (16.7 mM). Colforsin 214-223 cathelicidin antimicrobial peptide Rattus norvegicus 129-133 9486142-3 1998 Sustained [Ca2+]i elevation, induced by high KCl (25 mM) at a basal glucose concentration (2.8 mM), was substantially reduced by cAMP-increasing agents, dibutyryl cAMP (DBcAMP, 5 mM), an adenylyl cyclase activator forskolin (10 microM), and an incretin glucagon-like peptide-1-(7-36) amide (10(-9) M), as well as by glucose (16.7 mM). Colforsin 214-223 cathelicidin antimicrobial peptide Rattus norvegicus 163-167 9486138-8 1998 Forskolin blocked ET-1-, PDGF-BB-, and PMA-induced ets-1 mRNA, as well as inositol phosphate formation, consistent with an effect through impairment of PKC activation. Colforsin 0-9 endothelin 1 Rattus norvegicus 18-22 9525090-9 1998 The three above mentioned ligands were tested on HeLa cells (cell line HA6) expressing recombinant human 5-HT1A receptors for their effects on forskolin-stimulated cAMP accumulation in intact cells. Colforsin 143-152 keratin 36 Homo sapiens 71-74 9486138-8 1998 Forskolin blocked ET-1-, PDGF-BB-, and PMA-induced ets-1 mRNA, as well as inositol phosphate formation, consistent with an effect through impairment of PKC activation. Colforsin 0-9 ETS proto-oncogene 1, transcription factor Rattus norvegicus 51-56 9525090-9 1998 The three above mentioned ligands were tested on HeLa cells (cell line HA6) expressing recombinant human 5-HT1A receptors for their effects on forskolin-stimulated cAMP accumulation in intact cells. Colforsin 143-152 5-hydroxytryptamine receptor 1A Homo sapiens 105-111 9463474-1 1998 Forskolin potently activates all cloned mammalian adenylyl cyclases except type IX by interacting with two homologous cytoplasmic domains (C1 and C2) that form the catalytic core. Colforsin 0-9 heterogeneous nuclear ribonucleoprotein C Homo sapiens 139-148 9504388-12 1998 Co-application of a number of drugs with actions on second messenger systems, in association with the second AMPA stimulus, revealed significant potentiation of the AMPA-induced release of [3H]-noradrenaline: forskolin (10 microM, +78%), Rp-cAMPS (100 microM, +65%), Ro 31-8220 (10 microM, +163%) and thapsigargin (100 pM, + 161%). Colforsin 209-218 calmodulin 2, pseudogene 1 Rattus norvegicus 241-246 9473343-6 1998 A 4-h treatment with forskolin (10(-5) M) induced a 2-fold stimulation of VEGF mRNA expression in smooth muscle cells and fibroblasts, but, in contrast, did not affect VEGF expression in endothelial cells. Colforsin 21-30 vascular endothelial growth factor A Rattus norvegicus 74-78 9484653-5 1998 The increases in CD29 and CD54 staining were inhibited in a dose dependent manner by agents which increased intracellular cAMP levels including 100 microM 8-bromoadenosine 3":5"-cyclic monophosphate but not 8-bromoadenosine monophosphate, the phosphodiesterase inhibitor isobutyl methylxanthine and by direct activation of adenylate cyclase with forskolin. Colforsin 346-355 integrin subunit beta 1 Homo sapiens 17-21 9484653-5 1998 The increases in CD29 and CD54 staining were inhibited in a dose dependent manner by agents which increased intracellular cAMP levels including 100 microM 8-bromoadenosine 3":5"-cyclic monophosphate but not 8-bromoadenosine monophosphate, the phosphodiesterase inhibitor isobutyl methylxanthine and by direct activation of adenylate cyclase with forskolin. Colforsin 346-355 intercellular adhesion molecule 1 Rattus norvegicus 26-30 9447994-7 1998 A-CREB inhibited activation of CRE-mediated transcription evoked by three distinct stimuli: forskolin, which increases intracellular cAMP; membrane depolarization, which promotes Ca2+ influx; and nerve growth factor (NGF). Colforsin 92-101 cAMP responsive element binding protein 1 Rattus norvegicus 2-6 9514100-4 1998 Combinations of CT or FSK with IBMX exhibited additive effects on reduction of MT1-MMP mRNA expression and MMP-2 activation. Colforsin 22-25 matrix metallopeptidase 14 Homo sapiens 79-86 9514100-4 1998 Combinations of CT or FSK with IBMX exhibited additive effects on reduction of MT1-MMP mRNA expression and MMP-2 activation. Colforsin 22-25 matrix metallopeptidase 2 Homo sapiens 107-112 9536948-10 1998 The tyrosine kinase inhibitor herbimycin reduced the inhibitory effects of TNF-alpha against all stimuli but only reduced the effects of IL-1 beta against histamine and forskolin stimulation. Colforsin 169-178 interleukin-1 beta Oryctolagus cuniculus 137-146 9453547-7 1998 Elevation of cyclic AMP levels by either forskolin (10 microM) or dibutyryl cyclic AMP (1 mM) repressed GDNF secretion, as did treatment with the glucocorticoid dexamethasone (1 microM). Colforsin 41-50 glial cell derived neurotrophic factor Rattus norvegicus 104-108 9454810-4 1998 In vitro, SR 144528 antagonizes the inhibitory effects of the cannabinoid receptor agonist CP 55,940 on forskolin-stimulated adenylyl cyclase activity in cell lines permanently expressing the h CB2 receptor (EC50 = 10 nM) but not in cells expressing the h CB1 (no effect at 10 microM). Colforsin 104-113 cannabinoid receptor 2 Homo sapiens 194-197 9463474-3 1998 The C1/C2 complex has only one forskolin, one ATP, and one binding site for the alpha subunit of the G protein that stimulates adenylyl cyclase (Gsalpha) and its structure may be modeled using the three-dimensional structure of (IIC2/forskolin)2. Colforsin 234-243 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 145-152 9463474-5 1998 Thus, the forskolin-binding site is close to the Gsalpha-binding site but distal (15-20A) from the catalytic site. Colforsin 10-19 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 49-56 9425005-6 1998 However, when we treated the CA1 and CA3 synaptosomes with forskolin (an agent that enhances PKA activity) or induced Ca2+ influx into synaptosomes with high K+, rabphilin phosphorylation was increased selectively in mossy fiber CA3 synaptosomes, but not in CA1 synaptosomes. Colforsin 59-68 carbonic anhydrase 1 Homo sapiens 29-32 9578154-2 1998 We show that forskolin and 8-brcAMP, activators of PKA, amplify the AIF4(-)-induced stimulation of phosphatidylinositol-specific phospholipase C (phosphatidylinositol inositolphosphohydrolase; EC 3.1.4.3), measured by the formation of [3H]inositol phosphates in prelabeled cells. Colforsin 13-22 itchy E3 ubiquitin protein ligase Homo sapiens 68-72 9578154-3 1998 However, the AIF4(-)-stimulated production of 1,2-diacylglycerols and the release of [3H]arachidonic acid ([3H]AA) were inhibited 50-75% by forskolin and 8-bromocAMP. Colforsin 140-149 itchy E3 ubiquitin protein ligase Homo sapiens 13-17 9464366-8 1998 Antagonist activity was confirmed for these compounds by measuring their ability to antagonize (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibition of forskolin-stimulated cyclic-AMP in RGT cells transfected with human mGluR2 and mGluR3. Colforsin 167-176 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 235-241 9464366-8 1998 Antagonist activity was confirmed for these compounds by measuring their ability to antagonize (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibition of forskolin-stimulated cyclic-AMP in RGT cells transfected with human mGluR2 and mGluR3. Colforsin 167-176 glutamate receptor, ionotropic, AMPA3 (alpha 3) Mus musculus 246-252 9464367-8 1998 Antagonist activity was confirmed for these compounds by measuring their ability to antagonize (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells transfected with human mGluR2 and mGluR3. Colforsin 167-176 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 235-241 9464367-8 1998 Antagonist activity was confirmed for these compounds by measuring their ability to antagonize (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells transfected with human mGluR2 and mGluR3. Colforsin 167-176 glutamate receptor, ionotropic, AMPA3 (alpha 3) Mus musculus 246-252 9435270-4 1998 A significant increase in Posm after forskolin (FK) plus vasopressin (VP) was found in AQP2 transfected cells (39.9 +/- 8.2 vs. 12.5 +/- 3.3 cm.sec-1.10(-3)), but not in cells transfected with AQP1 (15.3 +/- 3.6 vs. 13.4 +/- 3.6 cm.sec-1.10(-3)). Colforsin 37-46 vasopressin Sus scrofa 70-72 9425005-6 1998 However, when we treated the CA1 and CA3 synaptosomes with forskolin (an agent that enhances PKA activity) or induced Ca2+ influx into synaptosomes with high K+, rabphilin phosphorylation was increased selectively in mossy fiber CA3 synaptosomes, but not in CA1 synaptosomes. Colforsin 59-68 carbonic anhydrase 3 Homo sapiens 37-40 9435270-4 1998 A significant increase in Posm after forskolin (FK) plus vasopressin (VP) was found in AQP2 transfected cells (39.9 +/- 8.2 vs. 12.5 +/- 3.3 cm.sec-1.10(-3)), but not in cells transfected with AQP1 (15.3 +/- 3.6 vs. 13.4 +/- 3.6 cm.sec-1.10(-3)). Colforsin 37-46 aquaporin 2 Sus scrofa 87-91 9425005-6 1998 However, when we treated the CA1 and CA3 synaptosomes with forskolin (an agent that enhances PKA activity) or induced Ca2+ influx into synaptosomes with high K+, rabphilin phosphorylation was increased selectively in mossy fiber CA3 synaptosomes, but not in CA1 synaptosomes. Colforsin 59-68 carbonic anhydrase 3 Homo sapiens 229-232 9435270-4 1998 A significant increase in Posm after forskolin (FK) plus vasopressin (VP) was found in AQP2 transfected cells (39.9 +/- 8.2 vs. 12.5 +/- 3.3 cm.sec-1.10(-3)), but not in cells transfected with AQP1 (15.3 +/- 3.6 vs. 13.4 +/- 3.6 cm.sec-1.10(-3)). Colforsin 37-46 aquaporin-1 Sus scrofa 193-197 9425005-6 1998 However, when we treated the CA1 and CA3 synaptosomes with forskolin (an agent that enhances PKA activity) or induced Ca2+ influx into synaptosomes with high K+, rabphilin phosphorylation was increased selectively in mossy fiber CA3 synaptosomes, but not in CA1 synaptosomes. Colforsin 59-68 carbonic anhydrase 1 Homo sapiens 258-261 9446794-2 1998 We have analyzed TTF-2 DNA-binding activity in primary cultures of dog thyrocytes maintained in control condition or in the presence of the cAMP agonist forskolin. Colforsin 153-162 transcription termination factor 2 Canis lupus familiaris 17-22 9446794-4 1998 TTF-2 DNA-binding activity was clearly detectable in nuclear extracts from unstimulated cells and appeared increased in forskolin-treated cells. Colforsin 120-129 transcription termination factor 2 Canis lupus familiaris 0-5 9797013-4 1998 Removal of fetal calf serum (FCS) from the culture medium or addition of forskolin or phorbol ester (TPA) also induced rapid elevation of aromatase mRNA and switching to exon 1c, whereas TGFbeta almost abolished the expression, suggesting that cancer cells might secret forskolin- or TPA-like stimulatory factors, or consume TGFbeta-like inhibitory factors in serum for expression of aromatase mRNA. Colforsin 73-82 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 138-147 9507195-2 1998 Multifibre nerve responses during noxious heating were enhanced by adding forskolin, an agent that elevates cAMP. Colforsin 74-83 cathelicidin antimicrobial peptide Homo sapiens 108-112 9781344-4 1998 The mouse lactoferrin gene responded to forskolin, cAMP, TPA and EGF stimulation via two adjacent enhancer elements, the CRE and EGFRE and collectively referred to as the Mitogen Response Unit (MRU). Colforsin 40-49 lactotransferrin Mus musculus 10-21 9535536-6 1998 In endothelin-1-preconstricted vessels, isoprenaline, PGE2, and forskolin (an activator of adenylyl cyclase) induced greater relaxations of pulmonary arteries of betamethasone-treated lambs than those of controls. Colforsin 64-73 EDN1 Ovis aries 3-15 9473629-6 1998 Transcription of the full-length OTR promoter was induced by forskolin and by the phorbol ester PMA, and a synergistic (17-fold) effect was observed in MCF7 cells treated with both agents. Colforsin 61-70 oxytocin receptor Homo sapiens 33-36 9473629-7 1998 Receptor binding studies using the OTR antagonist 125I-labeled ornithine vasotocin, and Western blot analyses of OTRs in MCF7 cells, showed that PMA and forskolin also increased the density of endogenous human oxytocin receptors. Colforsin 153-162 oxytocin receptor Homo sapiens 35-38 9492903-1 1998 The efficacy of the selective 5-HT1B receptor agonist CP 93,129 in inhibiting the forskolin-stimulated adenylyl cyclase activity in the rat substantia nigra was reduced by both moderate and intensive prolonged training compared with sedentary resting rats. Colforsin 82-91 5-hydroxytryptamine receptor 1B Rattus norvegicus 30-36 9472944-7 1998 Forskolin, cholera toxin, and 8-bromo-cAMP increased Inh-alpha production approximately 3.5-fold, and the effects were blocked by IGFBP-4 or -5. Colforsin 0-9 inhibin subunit alpha Rattus norvegicus 53-62 9472944-7 1998 Forskolin, cholera toxin, and 8-bromo-cAMP increased Inh-alpha production approximately 3.5-fold, and the effects were blocked by IGFBP-4 or -5. Colforsin 0-9 insulin-like growth factor binding protein 4 Rattus norvegicus 130-137 9472944-8 1998 Increases in Inh-alpha by FSH, IGF-I, forskolin, cholera toxin, and 8-bromo-cAMP were totally blocked by the protein tyrosine kinase inhibitor, tyrphostin A23. Colforsin 38-47 inhibin subunit alpha Rattus norvegicus 13-22 9405735-10 1998 Forskolin (10(-8) M) and dibutyryl cAMP (10(-3) M) increased IGF-I mRNA levels sixfold, and cotreatment with E2 did not affect these changes, consistent with a possible mediation of the estrogen effect on IGF-I gene expression by cAMP. Colforsin 0-9 insulin like growth factor 1 Homo sapiens 61-66 9405735-10 1998 Forskolin (10(-8) M) and dibutyryl cAMP (10(-3) M) increased IGF-I mRNA levels sixfold, and cotreatment with E2 did not affect these changes, consistent with a possible mediation of the estrogen effect on IGF-I gene expression by cAMP. Colforsin 0-9 insulin like growth factor 1 Homo sapiens 205-210 9797013-4 1998 Removal of fetal calf serum (FCS) from the culture medium or addition of forskolin or phorbol ester (TPA) also induced rapid elevation of aromatase mRNA and switching to exon 1c, whereas TGFbeta almost abolished the expression, suggesting that cancer cells might secret forskolin- or TPA-like stimulatory factors, or consume TGFbeta-like inhibitory factors in serum for expression of aromatase mRNA. Colforsin 73-82 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 384-393 9472478-8 1998 One microM isoproterenol and 5 microM forskolin induced phosphorylation of connexin43, as did 16 nanomolar TPA. Colforsin 38-47 gap junction protein alpha 1 Homo sapiens 75-85 9515168-4 1998 Phagocytosis and accumulation of PDE-4 and PKA near adherent zymosan were inhibited by elevating cAMP levels with forskolin or rolipram. Colforsin 114-123 phosphodiesterase 4A Homo sapiens 33-38 9515168-4 1998 Phagocytosis and accumulation of PDE-4 and PKA near adherent zymosan were inhibited by elevating cAMP levels with forskolin or rolipram. Colforsin 114-123 cathelicidin antimicrobial peptide Homo sapiens 97-101 9681295-0 1998 Progesterone receptor synthesis in human meningiomas: relation to the estrogen-induced proteins pS2 and cathepsin-D and influence of epidermal growth factor, Forskolin and phorbol ester in vitro. Colforsin 158-167 progesterone receptor Homo sapiens 0-21 9506824-5 1998 PGE2 and forskolin inhibited IL-2 production of Jurkat cells stimulated with concanavalin A. T-440 by itself did not affect IL-2 production, but significantly enhanced the effect of PGE2 on IL-2 production. Colforsin 9-18 interleukin 2 Homo sapiens 29-33 9506824-6 1998 The increase of intracellular cAMP by T-440, PGE2, forskolin and T-440 plus PGE2 was well correlated with the inhibition of IL-2 production. Colforsin 51-60 interleukin 2 Homo sapiens 124-128 9710361-8 1998 This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min. Colforsin 83-92 growth hormone releasing hormone Homo sapiens 216-219 9710361-8 1998 This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min. Colforsin 83-92 growth hormone 1 Homo sapiens 262-264 9710361-8 1998 This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min. Colforsin 83-92 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 299-303 9710361-8 1998 This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min. Colforsin 83-92 growth hormone releasing hormone Homo sapiens 386-389 9710361-8 1998 This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min. Colforsin 83-92 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 412-416 9595397-0 1998 Comparison of the regulation of endothelin-2 and endothelin-converting enzyme-1 b [correction of beta] by forskolin and TNF-alpha in ACHN cells. Colforsin 106-115 endothelin 2 Homo sapiens 32-44 9595434-13 1998 The effects of ISO and forskolin on attenuating ET-1-stimulated MAPK activity could be reversed by treating cells with H89, an inhibitor of protein kinase A. Colforsin 23-32 endothelin 1 Homo sapiens 48-52 9595434-13 1998 The effects of ISO and forskolin on attenuating ET-1-stimulated MAPK activity could be reversed by treating cells with H89, an inhibitor of protein kinase A. Colforsin 23-32 mitogen-activated protein kinase 3 Homo sapiens 64-68 9407310-6 1998 Stimulation of dye coupling and Cx43 gene transcription were reproduced by forskolin and 8Br-cAMP. Colforsin 75-84 gap junction protein, alpha 1 Rattus norvegicus 32-36 9407317-6 1998 Time-course studies indicated that RA elevated MMP-2 activity levels in the cultures within 16 h. This increase was inhibited by cycloheximide and was enhanced by forskolin. Colforsin 163-172 matrix metallopeptidase 2 Gallus gallus 47-52 9595397-3 1998 Treatment for 4 with TNF-alpha (3 ng/ml), forskolin (30 microM), or the combination caused significant increases in ET-2 release, TNF-alpha alone or in combination with forskolin increased ET-2 mRNA levels at 1 h and 2 h. After 4 h the expression of ET-2 mRNA was comparable to control levels. Colforsin 42-51 endothelin 2 Homo sapiens 116-120 9595397-1 1998 The effects on the expression and secretion of ET-2 of forskolin and tumor necrosis factor-alpha (TNF-alpha) were investigated using the human renal adenocarcinoma (ACHN) cell line. Colforsin 55-64 endothelin 2 Homo sapiens 47-51 9595397-3 1998 Treatment for 4 with TNF-alpha (3 ng/ml), forskolin (30 microM), or the combination caused significant increases in ET-2 release, TNF-alpha alone or in combination with forskolin increased ET-2 mRNA levels at 1 h and 2 h. After 4 h the expression of ET-2 mRNA was comparable to control levels. Colforsin 42-51 tumor necrosis factor Homo sapiens 130-139 9595397-3 1998 Treatment for 4 with TNF-alpha (3 ng/ml), forskolin (30 microM), or the combination caused significant increases in ET-2 release, TNF-alpha alone or in combination with forskolin increased ET-2 mRNA levels at 1 h and 2 h. After 4 h the expression of ET-2 mRNA was comparable to control levels. Colforsin 42-51 endothelin 2 Homo sapiens 189-193 9510022-7 1998 The effects of Shh on Nkr-3.1 expression were antagonized by a forskolin-induced increase in the activity of cyclic AMP-dependent protein kinase A. Additionally, we confirmed that the expression of the earliest expressed murine myogenic marker, myf 5, is also regulated by the axial structures but that Shh by itself is not capable of inducing or maintaining it. Colforsin 63-72 sonic hedgehog Mus musculus 15-18 9595397-3 1998 Treatment for 4 with TNF-alpha (3 ng/ml), forskolin (30 microM), or the combination caused significant increases in ET-2 release, TNF-alpha alone or in combination with forskolin increased ET-2 mRNA levels at 1 h and 2 h. After 4 h the expression of ET-2 mRNA was comparable to control levels. Colforsin 42-51 endothelin 2 Homo sapiens 189-193 9595397-3 1998 Treatment for 4 with TNF-alpha (3 ng/ml), forskolin (30 microM), or the combination caused significant increases in ET-2 release, TNF-alpha alone or in combination with forskolin increased ET-2 mRNA levels at 1 h and 2 h. After 4 h the expression of ET-2 mRNA was comparable to control levels. Colforsin 169-178 tumor necrosis factor Homo sapiens 21-30 9595397-3 1998 Treatment for 4 with TNF-alpha (3 ng/ml), forskolin (30 microM), or the combination caused significant increases in ET-2 release, TNF-alpha alone or in combination with forskolin increased ET-2 mRNA levels at 1 h and 2 h. After 4 h the expression of ET-2 mRNA was comparable to control levels. Colforsin 169-178 endothelin 2 Homo sapiens 116-120 9595397-3 1998 Treatment for 4 with TNF-alpha (3 ng/ml), forskolin (30 microM), or the combination caused significant increases in ET-2 release, TNF-alpha alone or in combination with forskolin increased ET-2 mRNA levels at 1 h and 2 h. After 4 h the expression of ET-2 mRNA was comparable to control levels. Colforsin 169-178 endothelin 2 Homo sapiens 189-193 9595397-3 1998 Treatment for 4 with TNF-alpha (3 ng/ml), forskolin (30 microM), or the combination caused significant increases in ET-2 release, TNF-alpha alone or in combination with forskolin increased ET-2 mRNA levels at 1 h and 2 h. After 4 h the expression of ET-2 mRNA was comparable to control levels. Colforsin 169-178 endothelin 2 Homo sapiens 189-193 9595397-4 1998 In contrast to ET-2, ECE-1 b [corrected] mRNA levels were increased by TNF-alpha only at 4 h. Forskolin increased expression of ET-2 mRNA at 1 and 4 but had no significant effect on expression of ECE-beta. Colforsin 94-103 endothelin 2 Homo sapiens 128-148 9496706-7 1998 In addition, receptor independent stimulation of adenylate cyclase by forskolin reveals an increased formation of cAMP in Phd expressing cells, which is accompanied by an increased binding of [3H]forskolin. Colforsin 70-79 phosducin Mus musculus 122-125 9496706-7 1998 In addition, receptor independent stimulation of adenylate cyclase by forskolin reveals an increased formation of cAMP in Phd expressing cells, which is accompanied by an increased binding of [3H]forskolin. Colforsin 196-205 phosducin Mus musculus 122-125 9698035-6 1998 However, PDE4 specific inhibitors (rolipram and RO-20-1724) promoted apoptosis within 5 h. In HL60 cells, other cAMP-eliciting reagents (8-bromo-cAMP, Sp-cAMP and forskolin) also inhibited apoptosis, while cell-permeable cGMP analogs did not affect apoptosis. Colforsin 163-172 phosphodiesterase 4A Homo sapiens 9-13 9808067-5 1998 When an effect of lysophosphatidic acid (LPA) stimulation on an adenylate cyclase activity was examined, LPA partly attenuated forskolin-stimulated adenylate cyclase activity via Gi because IAP pretreatment blocked the inhibitory effect of LPA. Colforsin 127-136 Cd47 molecule Rattus norvegicus 190-193 9585124-5 1998 Forskolin also inhibited the iNOS expression. Colforsin 0-9 nitric oxide synthase 2 Rattus norvegicus 29-33 9705607-6 1998 In addition to 8BrcAMP, other cAMP agonists such as dibutyryl-cAMP, forskolin, pertussis toxin, or prostaglandin E2 (PGE2) had the same inhibitory effect on GM-CSF stimulation by IL-1. Colforsin 68-77 colony stimulating factor 2 Homo sapiens 157-163 9510022-7 1998 The effects of Shh on Nkr-3.1 expression were antagonized by a forskolin-induced increase in the activity of cyclic AMP-dependent protein kinase A. Additionally, we confirmed that the expression of the earliest expressed murine myogenic marker, myf 5, is also regulated by the axial structures but that Shh by itself is not capable of inducing or maintaining it. Colforsin 63-72 myogenic factor 5 Mus musculus 245-250 9927231-3 1998 Of note however, when GM-CSF is used in combination with cAMP-elevating agents, an additive effect on neutrophil survival is observed with dibutyryl cAMP only, whereas supplementation of cell cultures with GM-CSF and forskolin results in a progressive reduction of antiapoptotic effects exerted by the single compounds. Colforsin 217-226 colony stimulating factor 2 Homo sapiens 22-28 9927231-4 1998 Moreover, although dibutyryl cAMP and forskolin do not affect Fas-triggered apoptotic events, they are still able to modulate the GM-CSF capacity to prolong neutrophil survival following anti-Fas IgM cell challenge, with effects similar to those respectively exerted on spontaneous neutrophil apoptosis. Colforsin 38-47 colony stimulating factor 2 Homo sapiens 130-136 9510022-7 1998 The effects of Shh on Nkr-3.1 expression were antagonized by a forskolin-induced increase in the activity of cyclic AMP-dependent protein kinase A. Additionally, we confirmed that the expression of the earliest expressed murine myogenic marker, myf 5, is also regulated by the axial structures but that Shh by itself is not capable of inducing or maintaining it. Colforsin 63-72 sonic hedgehog Mus musculus 303-306 9382934-4 1998 It was found that application of NPY, after the adenylyl-cyclase-activating drug forskolin, resulted in complete inhibition of forskolin-induced effects within approximately 20 min. Colforsin 81-90 neuropeptide Y Homo sapiens 33-36 9546582-9 1998 Cyclic AMP derivatives or cAMP generating agents such as PTH and forskolin inhibited ERK2 activation by bFGF and PDGF-BB suggesting a "cross-talk" between the two different signalling pathways activated by receptor tyrosine kinases and cAMP-dependent protein kinase. Colforsin 65-74 cathelicidin antimicrobial peptide Homo sapiens 26-30 9546582-9 1998 Cyclic AMP derivatives or cAMP generating agents such as PTH and forskolin inhibited ERK2 activation by bFGF and PDGF-BB suggesting a "cross-talk" between the two different signalling pathways activated by receptor tyrosine kinases and cAMP-dependent protein kinase. Colforsin 65-74 mitogen-activated protein kinase 1 Homo sapiens 85-89 9546582-9 1998 Cyclic AMP derivatives or cAMP generating agents such as PTH and forskolin inhibited ERK2 activation by bFGF and PDGF-BB suggesting a "cross-talk" between the two different signalling pathways activated by receptor tyrosine kinases and cAMP-dependent protein kinase. Colforsin 65-74 fibroblast growth factor 2 Homo sapiens 104-108 9546582-9 1998 Cyclic AMP derivatives or cAMP generating agents such as PTH and forskolin inhibited ERK2 activation by bFGF and PDGF-BB suggesting a "cross-talk" between the two different signalling pathways activated by receptor tyrosine kinases and cAMP-dependent protein kinase. Colforsin 65-74 cathelicidin antimicrobial peptide Homo sapiens 236-240 9680254-2 1998 LY341495 was a nanomolar potent antagonist of 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD)-induced inhibition of forskolin-stimulated cAMP formation at mGlu2 and mGlu3 receptors (respective IC50S of 0.021 and 0.014 microM). Colforsin 123-132 glutamate receptor, metabotropic 3 Mus musculus 172-177 9382934-4 1998 It was found that application of NPY, after the adenylyl-cyclase-activating drug forskolin, resulted in complete inhibition of forskolin-induced effects within approximately 20 min. Colforsin 127-136 neuropeptide Y Homo sapiens 33-36 9880083-8 1998 It is concluded that the Na+-K+-2Cl(-)-cotransporter of rat submandibular glands is activated by isoproterenol, forskolin, and neuropeptides of the VIP family by a mechanism involving cAMP-dependent processes. Colforsin 112-121 vasoactive intestinal peptide Rattus norvegicus 148-151 9426245-7 1997 On the other hand, the gene expression of GDNF in C6 glioma cells was transiently induced by treatment with phorbol myristate acetate (PMA), but not by forskolin. Colforsin 152-161 glial cell line derived neurotrophic factor Mus musculus 42-46 9690667-10 1998 Forskolin significantly stimulated the synthesis and secretion of the chromogranin B-derived peptide PE-11 and the secretogranin II-derived secretoneurin. Colforsin 0-9 chromogranin B Homo sapiens 70-84 9690667-10 1998 Forskolin significantly stimulated the synthesis and secretion of the chromogranin B-derived peptide PE-11 and the secretogranin II-derived secretoneurin. Colforsin 0-9 secretogranin II Homo sapiens 115-131 9442914-4 1997 Northern blot analysis revealed the expression of the VDR gene, the VDR mRNA bands being prominent in 1,25(OH)2D3, serum or forskolin treated fibroblasts. Colforsin 124-133 vitamin D receptor Homo sapiens 54-57 9448108-3 1997 When the confluent cells were incubated for 47 h after a 1 h-pulse exposure or continuously exposed to calcitonin and forskolin for 48 h, ALP activity in the cells was increased by calcitonin about 2-fold compared with the basal activity at the maximum level but was not dependent on the exposure time; it was markedly increased by forskolin in parallel with the exposure time. Colforsin 118-127 ALPA Sus scrofa 138-141 9448108-4 1997 The increase in activity produced by calcitonin was abolished by a PKA inhibitor H-89, and, in contrast, potentiated by a PKC inhibitor, NA-382 to near the forskolin-induced level. Colforsin 156-165 Calcitonin gene-related peptide Sus scrofa 37-47 9408240-5 1997 Precontraction of bovine carotid artery smooth muscle with serotonin followed by relaxation with forskolin was associated with increases in the phosphorylation of HSP27 and HSP20. Colforsin 97-106 heat shock protein beta-1 Bos taurus 163-168 9408240-5 1997 Precontraction of bovine carotid artery smooth muscle with serotonin followed by relaxation with forskolin was associated with increases in the phosphorylation of HSP27 and HSP20. Colforsin 97-106 heat shock protein beta-6 Bos taurus 173-178 9408240-6 1997 Precontraction of umbilical artery with serotonin followed by forskolin treatment led to increases in the phosphorylation of HSP27. Colforsin 62-71 heat shock protein family B (small) member 1 Homo sapiens 125-130 9408240-7 1997 However, the umbilical artery smooth muscle did not relax, nor was there an increase in the phosphorylation of HSP20 with forskolin treatment. Colforsin 122-131 heat shock protein family B (small) member 6 Homo sapiens 111-116 9442914-4 1997 Northern blot analysis revealed the expression of the VDR gene, the VDR mRNA bands being prominent in 1,25(OH)2D3, serum or forskolin treated fibroblasts. Colforsin 124-133 vitamin D receptor Homo sapiens 68-71 9440032-11 1997 The activity of adenylate cyclase, stimulated by forskolin, was inhibited by maximally 25% at 10(-6) M SST-14 or octreotide in one of 5 selected glioblastoma cell lines. Colforsin 49-58 somatostatin Homo sapiens 103-109 9450681-5 1997 Intracellular cAMP-raising agents, such as forskolin and 3-isobutyl-1-methylxanthine, partially prevented the SMase- and C2-ceramide-induced secretion of NGF to the cell supernatant. Colforsin 43-52 nerve growth factor Rattus norvegicus 154-157 9400371-5 1997 Forskolin, interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, or interferon (IFN)-gamma enhanced the LPS-induced iNOS expression. Colforsin 0-9 nitric oxide synthase 2 Rattus norvegicus 117-121 9417811-5 1997 Like CGRP, the cAMP agonists prostaglandin E2 (PGE2), dibutyryl cAMP (Bt2cAMP) and forskolin inhibit TNF-alpha production by osteoblasts. Colforsin 83-92 tumor necrosis factor Rattus norvegicus 101-110 9389528-7 1997 Forskolin [a guanine-nucleotide-binding protein (G(alpha)) agonist] stimulated c-fos mRNA, whereas 9-(tetrahydro-2-furyl) adenine (THFA) (a cAMP antagonist), 1,9 dideoxyforskolin (a cAMP independent analog of forskolin), and phorbol 12-myristate 13-acetate (a protein kinase C activator) did not. Colforsin 0-9 FBJ osteosarcoma oncogene Mus musculus 79-84 9405121-7 1997 Similarly, SRIF abolished the GH responses to an activator of adenylate cyclase (10 microM forskolin), a membrane-permeant cAMP analog (1 mM 8-bromo-cAMP), and a voltage-sensitive calcium channel agonist (1 microM Bay K 8644). Colforsin 91-100 somatostatin 1 Gallus gallus 11-15 9488231-6 1997 RESULTS: VIP treatment produced an increase in cortisol secretion without pre-incubation, but this was markedly enhanced by prior exposure of cells to forskolin. Colforsin 151-160 vasoactive intestinal peptide Homo sapiens 9-12 9488231-7 1997 VIP was potent, with a threshold of 10(-11) mol/l (n = 4), reaching a maximum 3.9+/-0.9-fold increase in effect on cells pre-exposed to forskolin (n = 4) by 3.3 x 10(-8) mol/l. Colforsin 136-145 vasoactive intestinal peptide Homo sapiens 0-3 9812342-9 1997 Pituitary cell incubation with 30 microM forskolin alone or in the presence of H2A or H2B, stimulated GH release in the same magnitude. Colforsin 41-50 histone cluster 1, H2bg Rattus norvegicus 86-89 9812342-9 1997 Pituitary cell incubation with 30 microM forskolin alone or in the presence of H2A or H2B, stimulated GH release in the same magnitude. Colforsin 41-50 gonadotropin releasing hormone receptor Rattus norvegicus 102-104 9517483-4 1997 The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription. Colforsin 16-25 cAMP responsive element modulator Homo sapiens 103-107 9517483-4 1997 The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription. Colforsin 16-25 cAMP responsive element modulator Homo sapiens 117-121 9517483-4 1997 The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription. Colforsin 16-25 cAMP responsive element modulator Homo sapiens 123-159 9517483-5 1997 Overexpression of ICER in cultured spinal cord neurons results in the repression of the c-fos and c-jun promoters induced by forskolin and glutamate. Colforsin 125-134 cAMP responsive element modulator Homo sapiens 18-22 9517483-5 1997 Overexpression of ICER in cultured spinal cord neurons results in the repression of the c-fos and c-jun promoters induced by forskolin and glutamate. Colforsin 125-134 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 88-93 9517483-5 1997 Overexpression of ICER in cultured spinal cord neurons results in the repression of the c-fos and c-jun promoters induced by forskolin and glutamate. Colforsin 125-134 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 98-103 9361190-5 1997 Both VEGF- and bFGF-induced Raf-1 activity are blocked in the presence of forskolin or 8-bromo-cAMP by 80%. Colforsin 74-83 vascular endothelial growth factor A Homo sapiens 5-10 9361190-5 1997 Both VEGF- and bFGF-induced Raf-1 activity are blocked in the presence of forskolin or 8-bromo-cAMP by 80%. Colforsin 74-83 fibroblast growth factor 2 Homo sapiens 15-19 9361190-5 1997 Both VEGF- and bFGF-induced Raf-1 activity are blocked in the presence of forskolin or 8-bromo-cAMP by 80%. Colforsin 74-83 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 28-33 9415711-5 1997 Further experiments demonstrated that the induction of alpha 1B-AR by forskolin requires new protein synthesis and is protein kinase A dependent. Colforsin 70-79 adrenoceptor alpha 1B Rattus norvegicus 55-66 9415398-4 1997 In culture, FSH or forskolin, activators of the protein kinase A (PKA) pathway, rapidly (2 h) and transiently increased sgk mRNA levels in undifferentiated granulosa cells. Colforsin 19-28 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 48-64 9415398-4 1997 In culture, FSH or forskolin, activators of the protein kinase A (PKA) pathway, rapidly (2 h) and transiently increased sgk mRNA levels in undifferentiated granulosa cells. Colforsin 19-28 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 66-69 9415711-6 1997 In DDT1MF-2 cells transfected with alpha 1B-AR gene P2 promoter/CAT constructs, both forskolin and dibutyryl cAMP significantly increased P2 promoter activity. Colforsin 85-94 adrenoceptor alpha 1B Rattus norvegicus 35-46 9415398-4 1997 In culture, FSH or forskolin, activators of the protein kinase A (PKA) pathway, rapidly (2 h) and transiently increased sgk mRNA levels in undifferentiated granulosa cells. Colforsin 19-28 serum/glucocorticoid regulated kinase 1 Rattus norvegicus 120-123 9415709-7 1997 Furthermore, high affinity [3H]forskolin binding experiments demonstrated that depalmitoylated Gs alpha is able to associated directly with AC during the state of opioid dependence even without preceding receptor activation. Colforsin 31-40 GNAS complex locus Homo sapiens 95-103 9415711-3 1997 Receptor binding assays, Northern blotting, and nuclear run-on analyses demonstrated that forskolin (1 microM) in the presence of isobutylmethylxanthine (0.25 mM) increased alpha 1B-AR numbers, mRNA level, and gene transcription rate by 2.3 +/- 0.2-, 2.5 +/- 0.3-, and 3.5 +/- 0.2-fold over control, respectively. Colforsin 90-99 adrenoceptor alpha 1B Rattus norvegicus 173-184 9415398-5 1997 Sgk mRNA exhibited a biphasic expression pattern, with maximal levels observed at 48 h of FSH/forskolin as granulosa cells differentiate to the preovulatory phenotype. Colforsin 94-103 serum/glucocorticoid regulated kinase 1 Rattus norvegicus 0-3 9415398-6 1997 Deletion analyses using sgk promoter-reporter constructs (-4.0 kb to -35 bp) identified a region between -63 and -43 bp that mediated FSH and forskolin-responsive transcription in undifferentiated and differentiated granulosa cells. Colforsin 142-151 serum/glucocorticoid regulated kinase 1 Rattus norvegicus 24-27 9368026-2 1997 OC expression is up-regulated in part by signals initiated by basic fibroblast growth factor (FGF2), cyclic AMP or forskolin (FSK), and calcitriol via defined elements and DNA-protein interactions in the OC promoter. Colforsin 126-129 bone gamma-carboxyglutamate protein Rattus norvegicus 0-2 9359899-5 1997 When 5-HT or CGRP was added after the administration of forskolin, the responses were not observed. Colforsin 56-65 calcitonin-related polypeptide alpha Rattus norvegicus 13-17 9368026-2 1997 OC expression is up-regulated in part by signals initiated by basic fibroblast growth factor (FGF2), cyclic AMP or forskolin (FSK), and calcitriol via defined elements and DNA-protein interactions in the OC promoter. Colforsin 126-129 bone gamma-carboxyglutamate protein Rattus norvegicus 204-206 9368026-2 1997 OC expression is up-regulated in part by signals initiated by basic fibroblast growth factor (FGF2), cyclic AMP or forskolin (FSK), and calcitriol via defined elements and DNA-protein interactions in the OC promoter. Colforsin 115-124 bone gamma-carboxyglutamate protein Rattus norvegicus 0-2 9368026-4 1997 In this study, we examine the effects of Msx2 expression on OC promoter activation (luciferase reporter) by FGF2/FSK and calcitriol in MC3T3-E1 osteoblasts. Colforsin 113-116 msh homeobox 2 Rattus norvegicus 41-45 9368026-4 1997 In this study, we examine the effects of Msx2 expression on OC promoter activation (luciferase reporter) by FGF2/FSK and calcitriol in MC3T3-E1 osteoblasts. Colforsin 113-116 bone gamma-carboxyglutamate protein Rattus norvegicus 60-62 9368026-6 1997 By contrast, OC promoter induction by FGF2/FSK is completely abrogated by Msx2. Colforsin 43-46 bone gamma-carboxyglutamate protein Rattus norvegicus 13-15 9368026-8 1997 Treatment of MC3T3-E1 cells with FGF2/FSK or calcitriol up-regulates specific DNA-protein interactions at the OCFRE or VDRE, respectively, as detected by gel shift assay. Colforsin 38-41 fibroblast growth factor 2 Mus musculus 33-37 9368026-15 1997 Thus, Msx2 abrogates up-regulation of the OC promoter by FGF2/FSK in part by inhibiting OCFREB binding to the OCFRE. Colforsin 62-65 msh homeobox 2 Rattus norvegicus 6-10 9397179-3 1997 Studies of inhibition of the forskolin-stimulated cAMP formation mediated by the human 5-HT1B receptor demonstrate that the nature of the arylpiperazide substituent modulates the intrinsic activity of these 1-NP derivatives. Colforsin 29-38 5-hydroxytryptamine receptor 1B Homo sapiens 87-93 9368026-15 1997 Thus, Msx2 abrogates up-regulation of the OC promoter by FGF2/FSK in part by inhibiting OCFREB binding to the OCFRE. Colforsin 62-65 bone gamma-carboxyglutamate protein Rattus norvegicus 42-44 9404722-8 1997 In addition, rCM and hCM each enhanced BDNF-, forskolin-, or PMA-stimulated NPY production by rat aggregates. Colforsin 46-55 neuropeptide Y Rattus norvegicus 76-79 9374736-5 1997 A combination of the adenylate cyclase agonist forskolin and CNP demonstrated a synergistic ability to induce Cl- secretion across the nasal epithelium of CFTR(delta F/delta F) mice. Colforsin 47-56 cystic fibrosis transmembrane conductance regulator Mus musculus 155-159 9348319-10 1997 The effects of PGE2 on IL-12 synthesis and CD83 expression could be mimicked by dibutyryl-cAMP and forskolin, indicating that they were due to the intracellular elevation of cAMP levels. Colforsin 99-108 CD83 molecule Homo sapiens 43-47 9409469-16 1997 The synergistic activation of CFTR by low concentrations of FSK and GST cannot be explained by either a GST-induced elevation of cAMP concentration or inhibition of serine/threonine phosphatase. Colforsin 60-63 ATP-binding cassette sub-family C member 7 Cavia porcellus 30-34 9374665-4 1997 Treatments with forskolin, phorbol 12-myristate 13-acetate, staurosporine, and genistein also induced cell shape change and decreased F-actin staining and ET-1 mRNA levels. Colforsin 16-25 endothelin 1 Bos taurus 155-159 9409309-7 1997 When HUVECs were treated with forskolin (FK) (100 and 25 mumol/l), there was a decrease in the appearance of the 64 to 62 kDa doublet, suggesting an inhibition of the fully activated form of MMP-2. Colforsin 30-39 matrix metallopeptidase 2 Homo sapiens 191-196 9409229-5 1997 Cicaprost as well as forskolin significantly inhibited TNF-alpha- and IL-1 beta-induced cell surface expression of ICAM-1 and VCAM-1. Colforsin 21-30 tumor necrosis factor Homo sapiens 55-64 9409229-5 1997 Cicaprost as well as forskolin significantly inhibited TNF-alpha- and IL-1 beta-induced cell surface expression of ICAM-1 and VCAM-1. Colforsin 21-30 interleukin 1 beta Homo sapiens 70-79 9409229-5 1997 Cicaprost as well as forskolin significantly inhibited TNF-alpha- and IL-1 beta-induced cell surface expression of ICAM-1 and VCAM-1. Colforsin 21-30 intercellular adhesion molecule 1 Homo sapiens 115-121 9409229-5 1997 Cicaprost as well as forskolin significantly inhibited TNF-alpha- and IL-1 beta-induced cell surface expression of ICAM-1 and VCAM-1. Colforsin 21-30 vascular cell adhesion molecule 1 Homo sapiens 126-132 9366770-11 1997 Forskolin-inhibited bacterial lipopolysaccharide stimulated TNF-alpha release. Colforsin 0-9 tumor necrosis factor Homo sapiens 60-69 9366770-16 1997 Similar inhibition by forskolin and 8-Br-cAMP on TNF-alpha release was obtained with smooth muscle cells from saphenous vein. Colforsin 22-31 tumor necrosis factor Homo sapiens 49-58 9366770-12 1997 In the presence of lipopolysaccharide and forskolin, TNF-alpha release at 6 hrs was 8.6 +/- 1.5 U/mg of cell protein (p < .05 vs. in the presence of bacterial lipopolysaccharide alone). Colforsin 42-51 tumor necrosis factor Homo sapiens 53-62 9366770-17 1997 Finally, in tissue segments from either internal mammary artery or saphenous vein, both forskolin and 8-Br-cAMP inhibited lipopolysaccharide-stimulated TNF-alpha release. Colforsin 88-97 tumor necrosis factor Homo sapiens 152-161 9348193-10 1997 Stimulation of luciferase activity and PGHS-2 mRNA levels by other agonists, including interleukin-1, TGF alpha, forskolin, and phorbol 13-myristate 12-acetate, were enhanced by TGFbeta. Colforsin 113-122 prostaglandin-endoperoxide synthase 2 Mus musculus 39-45 9348193-10 1997 Stimulation of luciferase activity and PGHS-2 mRNA levels by other agonists, including interleukin-1, TGF alpha, forskolin, and phorbol 13-myristate 12-acetate, were enhanced by TGFbeta. Colforsin 113-122 transforming growth factor, beta 1 Mus musculus 178-185 9367644-6 1997 Forskolin, an activator of adenylate cyclase, and dibutylyl cAMP, a cyclic AMP analog, could also induce thioredoxin and extend survival of retinal pigment epithelial cells. Colforsin 0-9 thioredoxin Homo sapiens 105-116 9425443-2 1997 Studies with the IB3 human CF-derived respiratory epithelial line as a model target for CF gene therapy and forskolin to elevate cAMP levels demonstrated that following infection with the AdCF126(CRE8) CFTR vector, there was a marked increase in CFTR mRNA levels after forskolin addition. Colforsin 108-117 CF transmembrane conductance regulator Homo sapiens 202-206 9334390-5 1997 In contrast, the D2 receptor agonist quinpirole decreased basal as well as D1 agonist-, forskolin-, and 8-bromo-cAMP-stimulated phosphorylation of DARPP-32. Colforsin 88-97 dopamine receptor D2 Mus musculus 17-28 9334390-5 1997 In contrast, the D2 receptor agonist quinpirole decreased basal as well as D1 agonist-, forskolin-, and 8-bromo-cAMP-stimulated phosphorylation of DARPP-32. Colforsin 88-97 protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus 147-155 9351968-3 1997 AT1-R mRNA levels are rapidly reduced by forskolin treatment, in which the maximal effect yields an 80% reduction in AT1-R mRNA levels after 6 hr of treatment. Colforsin 41-50 angiotensin II receptor, type 1a Rattus norvegicus 0-5 9351968-3 1997 AT1-R mRNA levels are rapidly reduced by forskolin treatment, in which the maximal effect yields an 80% reduction in AT1-R mRNA levels after 6 hr of treatment. Colforsin 41-50 angiotensin II receptor, type 1a Rattus norvegicus 117-122 9351968-4 1997 The rate of AT1-R mRNA decay in response to forskolin is greater than its apparent intrinsic decay, as assessed in the presence of the transcriptional inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, suggesting forskolin treatment destabilizes the AT1-R mRNA. Colforsin 44-53 angiotensin II receptor, type 1a Rattus norvegicus 12-17 9351968-4 1997 The rate of AT1-R mRNA decay in response to forskolin is greater than its apparent intrinsic decay, as assessed in the presence of the transcriptional inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, suggesting forskolin treatment destabilizes the AT1-R mRNA. Colforsin 44-53 angiotensin II receptor, type 1a Rattus norvegicus 259-264 9425443-2 1997 Studies with the IB3 human CF-derived respiratory epithelial line as a model target for CF gene therapy and forskolin to elevate cAMP levels demonstrated that following infection with the AdCF126(CRE8) CFTR vector, there was a marked increase in CFTR mRNA levels after forskolin addition. Colforsin 269-278 CF transmembrane conductance regulator Homo sapiens 202-206 9362361-8 1997 The functional activity of Gs alpha, as determined by adenylyl cyclase (AC) activity, was significantly decreased in tumor as compared to normal liver under both basal and agonist stimulated (guanosine triphosphate gamma S and forskolin) conditions. Colforsin 227-236 GNAS complex locus Homo sapiens 27-35 9328832-8 1997 Activation of the cAMP-PKA pathway by treatment with forskolin induced a comparable level of induction with PTH. Colforsin 53-62 parathyroid hormone Homo sapiens 108-111 9328832-13 1997 These results demonstrate PTH, forskolin, the PTHrP analog RS-66271, and IL-1 alpha stimulate IL-6 expression by stimulating gene transcription. Colforsin 31-40 interleukin 6 Homo sapiens 94-98 9328832-14 1997 The response to forskolin suggests that the messenger system mediated by PKA is sufficient to induce IL-6 expression. Colforsin 16-25 interleukin 6 Homo sapiens 101-105 9353393-4 1997 The activity of these compounds was investigated in three different assays: stimulation of [35S]GTPgammaS binding and inhibition of forskolin-stimulated cAMP accumulation in Chinese hamster ovary cells transfected with ORL1, and inhibition of electrically induced contractions in the mouse vas deferens. Colforsin 132-141 opioid receptor-like 1 Mus musculus 219-223 9408887-8 1997 At a dose of 10 mumol/L, forskolin induced PTP1D mRNA expression almost two times higher than control values. Colforsin 25-34 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 43-48 9351968-4 1997 The rate of AT1-R mRNA decay in response to forskolin is greater than its apparent intrinsic decay, as assessed in the presence of the transcriptional inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, suggesting forskolin treatment destabilizes the AT1-R mRNA. Colforsin 222-231 angiotensin II receptor, type 1a Rattus norvegicus 12-17 9351968-5 1997 Nuclear run-on analysis indicates forskolin treatment does not affect transcription of the AT1-R gene in VSMCs, implying induced AT1-R mRNA destabilization accounts for the entire effect of forskolin in decreasing AT1-R mRNA levels. Colforsin 190-199 angiotensin II receptor, type 1a Rattus norvegicus 129-134 9351968-5 1997 Nuclear run-on analysis indicates forskolin treatment does not affect transcription of the AT1-R gene in VSMCs, implying induced AT1-R mRNA destabilization accounts for the entire effect of forskolin in decreasing AT1-R mRNA levels. Colforsin 190-199 angiotensin II receptor, type 1a Rattus norvegicus 129-134 9351968-8 1997 Similarly, forskolin elicits reductions in AT1-R mRNA, which occur at concentrations that fail to elicit a detectable production of cAMP. Colforsin 11-20 angiotensin II receptor, type 1a Rattus norvegicus 43-48 9406911-14 1997 However, co-treatment of 10 ng/ml aFGF with either (250 microM) IBMX or (10 microM) forskolin resulted in the novel expression of TH in 25% of plated neurons. Colforsin 84-93 fibroblast growth factor 1 Homo sapiens 34-38 9306012-7 1997 Fsk and IBMX depolarized wt-CFTR-expressing CHO cells significantly (from -40 +/- 1.5 to -32 +/- 1.6 mV, n = 41) and enhanced Gm strongly from 5.0 +/- 0.9 to 36 +/- 3.9 nS (n = 65). Colforsin 0-3 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 28-32 9341200-4 1997 In immunoprecipitation experiments employing alpha-toxin-permeabilized betaTC3 cells, elevation of intracellular Ca2+ or addition of forskolin, an adenylate cyclase activator, induced significant phosphorylation of MAP-2 in situ. Colforsin 133-142 microtubule-associated protein 2 Mus musculus 215-220 9341200-6 1997 H-89, a specific and potent inhibitor of cAMP-dependent protein kinase (PKA), prevented forskolin-induced MAP-2 phosphorylation but had little effect on MAP-2 phosphorylation stimulated by elevated Ca2+. Colforsin 88-97 microtubule-associated protein 2 Mus musculus 106-111 9366517-4 1997 In this study, we show that the WT1 protein expressed exogenously in fibroblasts was phosphorylated in vivo, and that treatment with forskolin, which activates the cAMP-dependent protein kinase (PKA) in vivo, induced phosphorylation of additional sites in WT1. Colforsin 133-142 WT1 transcription factor Homo sapiens 32-35 9366517-4 1997 In this study, we show that the WT1 protein expressed exogenously in fibroblasts was phosphorylated in vivo, and that treatment with forskolin, which activates the cAMP-dependent protein kinase (PKA) in vivo, induced phosphorylation of additional sites in WT1. Colforsin 133-142 WT1 transcription factor Homo sapiens 256-259 9406930-4 1997 Alternate BDNF transcripts were elevated to varying degrees after treatment with this ionophore and a subset of these transcripts was elevated following forskolin + IBMX treatment. Colforsin 153-162 brain-derived neurotrophic factor Rattus norvegicus 10-14 9406911-14 1997 However, co-treatment of 10 ng/ml aFGF with either (250 microM) IBMX or (10 microM) forskolin resulted in the novel expression of TH in 25% of plated neurons. Colforsin 84-93 tyrosine hydroxylase Homo sapiens 130-132 9406911-15 1997 The number of TH-expressing neurons was increased to 55% in aFGF-treated cultures co-incubated with aFGF and both (250 microM) IBMX and (10 microM) forskolin. Colforsin 148-157 tyrosine hydroxylase Homo sapiens 14-16 9406911-15 1997 The number of TH-expressing neurons was increased to 55% in aFGF-treated cultures co-incubated with aFGF and both (250 microM) IBMX and (10 microM) forskolin. Colforsin 148-157 fibroblast growth factor 1 Homo sapiens 60-64 9406911-17 1997 Induction of TH by aFGF and IBMX/forskolin was partially blocked by inhibitors of protein kinase, such as H7, H8 and H89, as well as pretreatment with protein (cyclohexamide) or RNA synthesis (amanitin and actinomycin D) inhibitors. Colforsin 33-42 tyrosine hydroxylase Homo sapiens 13-15 9406911-18 1997 The concomitant addition of combinations of co-activator molecules (DA, TPA and IBMX/forskolin) and aFGF resulted in the additive induction of TH. Colforsin 85-94 tyrosine hydroxylase Homo sapiens 143-145 9366262-3 1997 Using cells metabolically labeled with [32P]phosphate, TPA caused concerted stimulation of basal and forskolin activated adenylyl cyclase together with incorporation of [32P]phosphate into AC II protein. Colforsin 101-110 plasminogen activator, tissue type Homo sapiens 55-58 9344607-4 1997 The induction of HSP70 by butyrate was inhibited by the simultaneous addition of cAMP-increasing agents (dibutyryl cAMP or the combination of forskolin plus theophylline). Colforsin 142-151 heat shock protein family A (Hsp70) member 4 Homo sapiens 17-22 9365911-7 1997 Both the CRH-induced depolarization and [Ca2+]i elevation could be mimicked by extracellular application of the adenylate cyclase activator forskolin or the membrane-permeable cAMP analogue, 8-(4-chlorophenylthio)-adenosine-3",5"-cyclic monophosphate (8-CPT-cAMP). Colforsin 140-149 corticotropin releasing hormone Rattus norvegicus 9-12 9362453-5 1997 Binding of MEL cell nuclear proteins to a NF-kappaB recognition sequence in c-myb intron I was strongly induced by 8-Br-cAMP or forskolin; induction was delayed and correlated with the up-regulation of c-myb. Colforsin 128-137 myeloblastosis oncogene Mus musculus 76-81 9362453-5 1997 Binding of MEL cell nuclear proteins to a NF-kappaB recognition sequence in c-myb intron I was strongly induced by 8-Br-cAMP or forskolin; induction was delayed and correlated with the up-regulation of c-myb. Colforsin 128-137 myeloblastosis oncogene Mus musculus 202-207 9362453-7 1997 8-Br-cAMP and forskolin also increased the DNA binding activity of AP-1 complexes containing JunB, JunD and c-Fos in MEL cells which could cooperate with NF-kappaB. Colforsin 14-23 jun B proto-oncogene Mus musculus 93-97 9362453-7 1997 8-Br-cAMP and forskolin also increased the DNA binding activity of AP-1 complexes containing JunB, JunD and c-Fos in MEL cells which could cooperate with NF-kappaB. Colforsin 14-23 jun D proto-oncogene Mus musculus 99-103 9384238-4 1997 Nociceptin inhibited forskolin-stimulated increases in intracellular cAMP with an IC50 of 70 pM. Colforsin 21-30 prepronociceptin Cricetulus griseus 0-10 9326243-8 1997 Finally, we provide evidence that C2-ceramide, calcium ionophore, and forskolin (which increases intracellular levels of cAMP) independently induce apoptosis of CD77+ BL cells and, moreover, that C2-ceramide and forskolin strongly synergize to cause cell death. Colforsin 70-79 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 161-165 9384224-6 1997 Serotonin-like activity was seen in in vitro functional assays including inhibition of forskolin-stimulated cAMP accumulation in human 5-HT1D receptor-transfected fibroblasts or eliciting vasoconstriction in isolated human pial arteries. Colforsin 87-96 5-hydroxytryptamine receptor 1D Homo sapiens 135-141 9352075-2 1997 Isoproterenol, forskolin, and CPS-cAMP markedly stimulated the phosphorylation of CREB in parotid acinar cells, and PKA inhibitors H-8 and H-89 dose-dependently inhibited it. Colforsin 15-24 cAMP responsive element binding protein 1 Homo sapiens 82-86 9314578-3 1997 In a mouse Leydig cell line (MA-10) we show that hCG and forskolin are effective inducers of progesterone production and P450scc expression. Colforsin 57-66 cytochrome P450, family 11, subfamily a, polypeptide 1 Mus musculus 121-128 9314578-6 1997 The transcriptional activity of SF-1, measured by induction of an SF-1 synthetic reporter, was only minimally increased by forskolin. Colforsin 123-132 splicing factor 1 Mus musculus 32-36 9362453-7 1997 8-Br-cAMP and forskolin also increased the DNA binding activity of AP-1 complexes containing JunB, JunD and c-Fos in MEL cells which could cooperate with NF-kappaB. Colforsin 14-23 FBJ osteosarcoma oncogene Mus musculus 108-113 9336410-8 1997 Studies of mRNA half-life showed that both NECA and forskolin decreased the half-life of collagenase mRNA in IL-1-stimulated FLS and HS68 cells. Colforsin 52-61 interleukin 1 alpha Homo sapiens 109-113 9314572-5 1997 Although ovarian steroids showed no effect on OT receptors, forskolin (an adenylate cyclase activator) and dibutyryl cAMP caused 1.5- to 1.6-fold increases in specific binding of OT without changing the binding affinity. Colforsin 60-69 oxytocin/neurophysin I prepropeptide Homo sapiens 179-181 9329361-4 1997 Forskolin treatment also caused an increase in KGF mRNA but not to the levels attained with tetradecanoyl phorbol acetate treatment. Colforsin 0-9 fibroblast growth factor 7 Homo sapiens 47-50 9353595-2 1997 Human dopamine (DA) D2long (hD2L) receptors, expressed by Ltk- cells, can be up-regulated by treating the cells with forskolin for 16 hr (Johansson and Westlind-Danielsson, 1994). Colforsin 117-126 leukocyte receptor tyrosine kinase Homo sapiens 58-61 9353595-9 1997 Forskolin also produced an increase in the level of the DA hD2short (hD2S) receptor expressed by Ltk- cells. Colforsin 0-9 leukocyte receptor tyrosine kinase Homo sapiens 97-100 9322976-9 1997 PMA increased mRNA for MCP-1 at 4, 12, and 24 h. Treatment with LH or forskolin transiently decreased MCP-1 mRNA expression. Colforsin 70-79 C-C motif chemokine 2 Bos taurus 23-28 9322976-9 1997 PMA increased mRNA for MCP-1 at 4, 12, and 24 h. Treatment with LH or forskolin transiently decreased MCP-1 mRNA expression. Colforsin 70-79 C-C motif chemokine 2 Bos taurus 102-107 9312201-8 1997 The effects of forskolin were unchanged by pretreatment with the PKC blocker. Colforsin 15-24 protein kinase C, gamma Rattus norvegicus 65-68 9322912-4 1997 In response to 10 microM forskolin and to various concentrations of isoproterenol (0.1-3.0 microM), cAMP accumulation was reduced in the G alpha(s) knockout ES cell lines, relative to wild-type ES cells and to five of six ES cell lines with randomly integrated targeting vector. Colforsin 25-34 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 137-147 9364935-6 1997 Upon stimulation of the cells with the adenylate cyclase-activator forskolin, a DNase I-hypersensitive site is induced in the distal promoter region. Colforsin 67-76 deoxyribonuclease 1 Bos taurus 80-87 9333129-4 1997 In baby hamster kidney cells transfected with the human CT receptor, phosphorylation of the receptor increased approximately 2.5-fold after cells were treated with calcitonin, phorbol ester, forskolin, or calcitonin plus phorbol ester. Colforsin 191-200 calcitonin receptor Homo sapiens 56-67 9336342-3 1997 Prostaglandin E2 and forskolin raised intracellular cAMP level of Dermatophagoides farinae extract-reactive human T cell line and inhibited T cell receptor-stimulated IL-5 production. Colforsin 21-30 interleukin 5 Homo sapiens 167-171 9326272-4 1997 The phosphodiesterase type IV inhibitor, rolipram, was able to potentiate the inhibitory effect of forskolin on ICAM-1 and VCAM-1 gene expression. Colforsin 99-108 intercellular adhesion molecule 1 Homo sapiens 112-118 9326272-4 1997 The phosphodiesterase type IV inhibitor, rolipram, was able to potentiate the inhibitory effect of forskolin on ICAM-1 and VCAM-1 gene expression. Colforsin 99-108 vascular cell adhesion molecule 1 Homo sapiens 123-129 9326272-5 1997 Inhibition of tumor necrosis factor-alpha-induced VCAM-1 mRNA levels by forskolin was partially due to enhanced degradation of VCAM-1 message, whereas the decay rates of tumor necrosis factor-alpha-induced ICAM-1 message and interleukin-1beta-induced ICAM-1/VCAM-1 message were not affected by forskolin treatment. Colforsin 72-81 tumor necrosis factor Homo sapiens 14-41 9326272-5 1997 Inhibition of tumor necrosis factor-alpha-induced VCAM-1 mRNA levels by forskolin was partially due to enhanced degradation of VCAM-1 message, whereas the decay rates of tumor necrosis factor-alpha-induced ICAM-1 message and interleukin-1beta-induced ICAM-1/VCAM-1 message were not affected by forskolin treatment. Colforsin 72-81 vascular cell adhesion molecule 1 Homo sapiens 50-56 9326272-5 1997 Inhibition of tumor necrosis factor-alpha-induced VCAM-1 mRNA levels by forskolin was partially due to enhanced degradation of VCAM-1 message, whereas the decay rates of tumor necrosis factor-alpha-induced ICAM-1 message and interleukin-1beta-induced ICAM-1/VCAM-1 message were not affected by forskolin treatment. Colforsin 72-81 vascular cell adhesion molecule 1 Homo sapiens 127-133 9326272-5 1997 Inhibition of tumor necrosis factor-alpha-induced VCAM-1 mRNA levels by forskolin was partially due to enhanced degradation of VCAM-1 message, whereas the decay rates of tumor necrosis factor-alpha-induced ICAM-1 message and interleukin-1beta-induced ICAM-1/VCAM-1 message were not affected by forskolin treatment. Colforsin 72-81 vascular cell adhesion molecule 1 Homo sapiens 127-133 9326272-5 1997 Inhibition of tumor necrosis factor-alpha-induced VCAM-1 mRNA levels by forskolin was partially due to enhanced degradation of VCAM-1 message, whereas the decay rates of tumor necrosis factor-alpha-induced ICAM-1 message and interleukin-1beta-induced ICAM-1/VCAM-1 message were not affected by forskolin treatment. Colforsin 294-303 tumor necrosis factor Homo sapiens 14-41 9326272-5 1997 Inhibition of tumor necrosis factor-alpha-induced VCAM-1 mRNA levels by forskolin was partially due to enhanced degradation of VCAM-1 message, whereas the decay rates of tumor necrosis factor-alpha-induced ICAM-1 message and interleukin-1beta-induced ICAM-1/VCAM-1 message were not affected by forskolin treatment. Colforsin 294-303 vascular cell adhesion molecule 1 Homo sapiens 50-56 9326272-5 1997 Inhibition of tumor necrosis factor-alpha-induced VCAM-1 mRNA levels by forskolin was partially due to enhanced degradation of VCAM-1 message, whereas the decay rates of tumor necrosis factor-alpha-induced ICAM-1 message and interleukin-1beta-induced ICAM-1/VCAM-1 message were not affected by forskolin treatment. Colforsin 294-303 tumor necrosis factor Homo sapiens 170-197 9350039-2 1997 Incubations of the [32P]-labelled cardiomyocytes with a beta-adrenoceptor agonist isoproterenol (10 microM) and with a plant diterpene forskolin (100 microM) which directly stimulates adenylyl cyclase increased the phosphorylation of an inhibitory subunit of troponin (TN-I) and phospholamban (PLN). Colforsin 135-144 phospholamban Rattus norvegicus 294-297 9350039-3 1997 Brief exposure (1 min) of labelled myocytes to the hydroxyl radical generating system (H2O2 plus FeCl2) decreased markedly the stimulatory action of isoproterenol and forskolin on TN-I and PLN phosphorylation. Colforsin 167-176 troponin I3, cardiac type Rattus norvegicus 180-184 9350039-2 1997 Incubations of the [32P]-labelled cardiomyocytes with a beta-adrenoceptor agonist isoproterenol (10 microM) and with a plant diterpene forskolin (100 microM) which directly stimulates adenylyl cyclase increased the phosphorylation of an inhibitory subunit of troponin (TN-I) and phospholamban (PLN). Colforsin 135-144 troponin I3, cardiac type Rattus norvegicus 259-267 9350039-2 1997 Incubations of the [32P]-labelled cardiomyocytes with a beta-adrenoceptor agonist isoproterenol (10 microM) and with a plant diterpene forskolin (100 microM) which directly stimulates adenylyl cyclase increased the phosphorylation of an inhibitory subunit of troponin (TN-I) and phospholamban (PLN). Colforsin 135-144 troponin I3, cardiac type Rattus norvegicus 269-273 9350039-3 1997 Brief exposure (1 min) of labelled myocytes to the hydroxyl radical generating system (H2O2 plus FeCl2) decreased markedly the stimulatory action of isoproterenol and forskolin on TN-I and PLN phosphorylation. Colforsin 167-176 phospholamban Rattus norvegicus 189-192 9350039-2 1997 Incubations of the [32P]-labelled cardiomyocytes with a beta-adrenoceptor agonist isoproterenol (10 microM) and with a plant diterpene forskolin (100 microM) which directly stimulates adenylyl cyclase increased the phosphorylation of an inhibitory subunit of troponin (TN-I) and phospholamban (PLN). Colforsin 135-144 phospholamban Rattus norvegicus 279-292 9309309-1 1997 Our recent studies determining the effect of cAMP-elevating agents forskolin and dibutyryl cAMP on ethanol-induced immunoreactive beta-endorphin (IR-beta-EP) release from hypothalamic cells in primary cultures suggested the possibility that both stimulatory and adaptive secretory responses of beta-EP neurons after ethanol exposure may involve the cAMP system. Colforsin 67-76 proopiomelanocortin Homo sapiens 130-144 9330437-6 1997 Finally, PCA-4230 also potentiated the forskolin- and sodium nitroprusside-inhibited serotonin release evoked by thrombin, probably related to the increased cyclic nucleotide level. Colforsin 39-48 prothrombin Oryctolagus cuniculus 113-121 9369342-5 1997 Here, 5-HT1A receptor activation was examined in vitro, by measuring forskolin-stimulated cAMP accumulation in HeLa cells expressing human 5-HT1A receptors, and in vivo, by using microdialysis to measure the extracellular concentration of hippocampal 5-hydroxytryptamine (5-HT) in rats. Colforsin 69-78 5-hydroxytryptamine receptor 1A Homo sapiens 6-21 9369342-5 1997 Here, 5-HT1A receptor activation was examined in vitro, by measuring forskolin-stimulated cAMP accumulation in HeLa cells expressing human 5-HT1A receptors, and in vivo, by using microdialysis to measure the extracellular concentration of hippocampal 5-hydroxytryptamine (5-HT) in rats. Colforsin 69-78 5-hydroxytryptamine receptor 1A Homo sapiens 6-12 9349586-7 1997 TGFbeta1 also suppressed (Bu)2 cyclic adenosine monophosphate (cAMP)- and forskolin-stimulated NIS mRNA and protein levels, indicating a role for TGFbeta1 downstream of cAMP production. Colforsin 74-83 transforming growth factor, beta 1 Rattus norvegicus 0-8 9349586-7 1997 TGFbeta1 also suppressed (Bu)2 cyclic adenosine monophosphate (cAMP)- and forskolin-stimulated NIS mRNA and protein levels, indicating a role for TGFbeta1 downstream of cAMP production. Colforsin 74-83 transforming growth factor, beta 1 Rattus norvegicus 146-154 9295336-9 1997 The two strongest agonists, epinephrine and fenoterol, provoked 11-13-fold increases in the level of betaAR phosphorylation after just 1 min, whereas the weak agonists dobutamine and ephedrine caused only 3-4-fold increases, similar to levels induced by cAMP-dependent protein kinase activation with forskolin. Colforsin 300-309 adrenoceptor beta 2 Homo sapiens 101-107 9294125-7 1997 By contrast, renin secretion from CaLu-6 cells comprised approximately 30% of cellular stores, yet was also stimulated twofold by 10 microM forskolin (P </= 0.001). Colforsin 140-149 renin Homo sapiens 13-18 9294125-8 1997 In JG cells, mechanical stretch inhibited basal renin release by 42% (P < 0.01) and forskolin-stimulated renin release by 25% (P < 0.05). Colforsin 87-96 renin Homo sapiens 108-113 9294125-9 1997 In CaLu-6 cells, stretch inhibited basal- and forskolin-stimulated renin release by 30 and 26%, respectively (both P < 0.01). Colforsin 46-55 renin Homo sapiens 67-72 9369342-6 1997 Nemonapride markedly decreased both forskolin-stimulated cAMP accumulation and the extracellular concentration of 5-HT; both effects were antagonized by the 5-HT1A receptor antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide (WAY100635). Colforsin 36-45 5-hydroxytryptamine receptor 1A Homo sapiens 157-172 9316420-2 1997 As measured by I- efflux, half-maximal concentration of agonist (K1/2) for forskolin-dependent activation was greater for delta F508-CFTR than wt-CFTR. Colforsin 75-84 cystic fibrosis transmembrane conductance regulator Mus musculus 133-137 9313930-6 1997 Using cilostamide or Ro 20-1724, we demonstrated that both PDE3 and PDE4 activities were increased following forskolin or 8-bromo-cyclic AMP treatment, with a relatively larger effect observed on PDE3 activity. Colforsin 109-118 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 59-63 9316420-2 1997 As measured by I- efflux, half-maximal concentration of agonist (K1/2) for forskolin-dependent activation was greater for delta F508-CFTR than wt-CFTR. Colforsin 75-84 cystic fibrosis transmembrane conductance regulator Mus musculus 146-150 9316420-4 1997 In cell-attached patches, 10 microM forskolin induced minimal delta F508-CFTR activity with characteristic prolonged closed times (estimated time constant, > 30 s). Colforsin 36-45 cystic fibrosis transmembrane conductance regulator Mus musculus 73-77 9316420-5 1997 Genistein increased the forskolin-induced macroscopic currents of wt-CFTR and delta F508-CFTR by 3- and 19-fold, respectively. Colforsin 24-33 cystic fibrosis transmembrane conductance regulator Mus musculus 69-73 9316420-5 1997 Genistein increased the forskolin-induced macroscopic currents of wt-CFTR and delta F508-CFTR by 3- and 19-fold, respectively. Colforsin 24-33 cystic fibrosis transmembrane conductance regulator Mus musculus 89-93 9316420-6 1997 Variance analysis suggested that in the presence of forskolin and genistein the open probabilities (Po) of wt- and delta F508-CFTR were identical. Colforsin 52-61 cystic fibrosis transmembrane conductance regulator Mus musculus 126-130 9316506-7 1997 Despite the marked increase in Bmax, however, IL-1 beta depressed adenosine 3",5"-cyclic monophosphate (cAMP) responses to isoproterenol and forskolin, a direct activator of AC (P < 0.001 by analysis of variance for both). Colforsin 141-150 interleukin 1 beta Homo sapiens 46-55 9291130-7 1997 Such inhibition was not due to an action on the catalytic unit of adenylate cyclase, as forskolin-stimulated cAMP production was unchanged by PMA treatment of COS cells that had been co-transfected with both the glucagon receptor and PKD. Colforsin 88-97 glucagon receptor Rattus norvegicus 212-229 9291137-5 1997 Cox-2 expression induced by U46619 or FGF-2 was similarly reduced by prostaglandin (PGE2), forskolin or dibutyryl-cAMP, suggesting a regulatory effect of adenylate cyclase on Cox-2 expression. Colforsin 91-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5 9291137-5 1997 Cox-2 expression induced by U46619 or FGF-2 was similarly reduced by prostaglandin (PGE2), forskolin or dibutyryl-cAMP, suggesting a regulatory effect of adenylate cyclase on Cox-2 expression. Colforsin 91-100 fibroblast growth factor 2 Homo sapiens 38-43 9291137-7 1997 The effects of PGE2 and forskolin on Cox-2 and phosphorylation of JNK1 were reversed with the protein kinase A inhibitor H89. Colforsin 24-33 mitochondrially encoded cytochrome c oxidase II Homo sapiens 37-42 9291137-7 1997 The effects of PGE2 and forskolin on Cox-2 and phosphorylation of JNK1 were reversed with the protein kinase A inhibitor H89. Colforsin 24-33 mitogen-activated protein kinase 8 Homo sapiens 66-70 9313930-6 1997 Using cilostamide or Ro 20-1724, we demonstrated that both PDE3 and PDE4 activities were increased following forskolin or 8-bromo-cyclic AMP treatment, with a relatively larger effect observed on PDE3 activity. Colforsin 109-118 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 196-200 9330595-7 1997 Finally, IL-1 beta inhibited progesterone responses to forskolin and PGE2 in ovarian dispersates: an effect not observed in GL cell-only cultures nor in co-cultures in which forskolin-induced progesterone production is always inhibited. Colforsin 55-64 interleukin 1 beta Rattus norvegicus 9-18 9376227-3 1997 The stimulatory effects of forskolin, vasoactive intestinal peptide (VIP) and isoproterenol on adenylyl cyclase activity increased between 0.5-3 mo, remained constant up to 12 mo and decreased thereafter, conceivably following the expression of VIP and beta-adrenergic receptors. Colforsin 27-36 vasoactive intestinal peptide Rattus norvegicus 245-248 9275048-10 1997 The protein kinase A (PKA) inhibitors, H-89 (10 microM; 30 min) and dideoxyadenosine (5 nM; 10 min) significantly decreased the forskolin- and dbcAMP-mediated PLD activation without any effect on the phorbol ester-mediated PLD response. Colforsin 128-137 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 4-20 9275048-10 1997 The protein kinase A (PKA) inhibitors, H-89 (10 microM; 30 min) and dideoxyadenosine (5 nM; 10 min) significantly decreased the forskolin- and dbcAMP-mediated PLD activation without any effect on the phorbol ester-mediated PLD response. Colforsin 128-137 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 22-25 9275048-12 1997 These studies indicate that forskolin and dbcAMP stimulate PLD in FRTL-5 thyroid cells directly via PKA without involvement of PKC. Colforsin 28-37 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 100-103 9330595-7 1997 Finally, IL-1 beta inhibited progesterone responses to forskolin and PGE2 in ovarian dispersates: an effect not observed in GL cell-only cultures nor in co-cultures in which forskolin-induced progesterone production is always inhibited. Colforsin 174-183 interleukin 1 beta Rattus norvegicus 9-18 9299372-5 1997 PKA activators such as forskolin (FSK), isobutylmethylxanthine, dibutyryl cAMP and isoproterenol, significantly activated Raf-1 and MAP kinases with a peak at 2 and 8 min, respectively, followed by an increase in protein synthesis in cardiac myocytes. Colforsin 23-32 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-3 9282941-11 1997 Forskolin stimulated AChE expression, an action that was blocked by the L-type VDCC antagonist nifedipine. Colforsin 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 9299372-5 1997 PKA activators such as forskolin (FSK), isobutylmethylxanthine, dibutyryl cAMP and isoproterenol, significantly activated Raf-1 and MAP kinases with a peak at 2 and 8 min, respectively, followed by an increase in protein synthesis in cardiac myocytes. Colforsin 23-32 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 122-127 9299372-8 1997 Furthermore, FSK and TPA synergistically activated Raf-1. Colforsin 13-16 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 51-56 9299372-5 1997 PKA activators such as forskolin (FSK), isobutylmethylxanthine, dibutyryl cAMP and isoproterenol, significantly activated Raf-1 and MAP kinases with a peak at 2 and 8 min, respectively, followed by an increase in protein synthesis in cardiac myocytes. Colforsin 34-37 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-3 9299372-5 1997 PKA activators such as forskolin (FSK), isobutylmethylxanthine, dibutyryl cAMP and isoproterenol, significantly activated Raf-1 and MAP kinases with a peak at 2 and 8 min, respectively, followed by an increase in protein synthesis in cardiac myocytes. Colforsin 34-37 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 122-127 9288733-5 1997 Leptin production was also detected in a cultured human choriocarcinoma cell line, BeWo cells, and was augmented during the course of forskolin-induced differentiation of cytotrophoblasts into syncytiotrophoblasts. Colforsin 134-143 leptin Homo sapiens 0-6 9280068-9 1997 Forskolin, (Bu)2-cAMP, 8-bromo-cAMP, and 8-(4-chlorophenylthio)-cAMP increased the MKP-1 mRNA content moderately above basal. Colforsin 0-9 dual specificity phosphatase 1 Rattus norvegicus 83-88 9236220-4 1997 PKA was induced by perfusing oocytes with a cocktail that contained forskolin, chlorophenylthio-cAMP, dibutyryl-cAMP, and 3-isobutyl-1-methylxanthine. Colforsin 68-77 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-3 9322226-2 1997 It has been shown that only opioid agonists which bind to delta receptors bring about a significant inhibition of the release of LHRH, when this is stimulated by forskolin- or PGE2. Colforsin 162-171 gonadotropin releasing hormone 1 Mus musculus 129-133 9268376-3 1997 In the presence of Gsalpha, adenylyl cyclase is activated in response to occupation of only one forskolin-binding site. Colforsin 96-105 GNAS complex locus Homo sapiens 19-26 9268376-5 1997 The affinity of forskolin for adenylyl cyclase is greatly reduced in the absence of Gsalpha ( approximately 40 microM). Colforsin 16-25 GNAS complex locus Homo sapiens 84-91 9277431-2 1997 Fos immunoreactivity was detected immunohistochemically following in vitro manipulations, which included distension, electrical stimulation, exposure to forskolin, and peristalsis. Colforsin 153-162 proto-oncogene c-Fos Cavia porcellus 0-3 9287125-4 1997 Biochemical analysis of DAC9 confirms it encodes a functional enzyme which can be activated by forskolin or G protein. Colforsin 95-104 Adenylyl cyclase 13E Drosophila melanogaster 24-28 9277566-6 1997 The increase in AC-III expression was paralleled by an increase in forskolin-stimulated AC activity in BAT membranes. Colforsin 67-76 adenylate cyclase 3 Rattus norvegicus 16-22 9277481-2 1997 AT1 mRNA expression in cultured bovine VSMC increased twofold after 8 h of protein kinase C (PKC) activation with phorbol 12-myristate 13-acetate (PMA), whereas stimulation with forskolin did not alter the AT1 mRNA level. Colforsin 178-187 angiotensin II receptor type 1 Bos taurus 0-3 9277405-4 1997 Gastrin release stimulated by terbutaline (beta 2-agonist) and forskolin was abolished by blockade of L-type VDCCs; the effect of 3.6 mM extracellular Ca2+ was only partially reversed. Colforsin 63-72 gastrin Homo sapiens 0-7 9303305-2 1997 Here we describe functional coupling of CCR-5 to inhibition of forskolin-stimulated cAMP formation via a pertussis toxin-sensitive G(i) protein mechanism in transfected HEK 293 cells. Colforsin 63-72 C-C motif chemokine receptor 5 Homo sapiens 40-45 9242182-10 1997 ET-1 antagonized IKs enhanced by histamine (250 nmol/L, n = 7) and forskolin (500 nmol/L, n = 7) but did not inhibit IKs enhanced by the internal application of cAMP (100 mumol/L, n = 6). Colforsin 67-76 endothelin-1 Cavia porcellus 0-4 9292955-9 1997 In contrast, both TSH (1 mU/mL) and forskolin (16 microM) decreased TGF beta 1 mRNA expression to about 70%, and this effect was abolished when follicles were pretreated with iodide (40 microM KI) in a concentration known to inhibit TSH action on cyclic adenosine monophosphate (cAMP) formation and proliferation. Colforsin 36-45 transforming growth factor beta 1 Homo sapiens 68-78 9231726-6 1997 Furthermore, cyclic AMP-elevating agents (dibutyryl cyclic AMP and forskolin) inhibited TNF-alpha/IL-1beta-induced and LPS-induced iNOS expression and nitrite accumulation. Colforsin 67-76 tumor necrosis factor Rattus norvegicus 88-97 9231726-6 1997 Furthermore, cyclic AMP-elevating agents (dibutyryl cyclic AMP and forskolin) inhibited TNF-alpha/IL-1beta-induced and LPS-induced iNOS expression and nitrite accumulation. Colforsin 67-76 interleukin 1 beta Rattus norvegicus 98-106 9231726-6 1997 Furthermore, cyclic AMP-elevating agents (dibutyryl cyclic AMP and forskolin) inhibited TNF-alpha/IL-1beta-induced and LPS-induced iNOS expression and nitrite accumulation. Colforsin 67-76 nitric oxide synthase 2 Rattus norvegicus 131-135 9213226-3 1997 In the current study, we show that either IGFBP-3 or IGFBP-5 are the major forms of IGFBP released from monolayers of human GM10 fibroblasts, T98G glioblastoma cells and forskolin-treated bovine MDBK cells. Colforsin 170-179 insulin like growth factor binding protein 3 Homo sapiens 42-49 9213226-3 1997 In the current study, we show that either IGFBP-3 or IGFBP-5 are the major forms of IGFBP released from monolayers of human GM10 fibroblasts, T98G glioblastoma cells and forskolin-treated bovine MDBK cells. Colforsin 170-179 insulin like growth factor binding protein 5 Homo sapiens 53-60 9213226-3 1997 In the current study, we show that either IGFBP-3 or IGFBP-5 are the major forms of IGFBP released from monolayers of human GM10 fibroblasts, T98G glioblastoma cells and forskolin-treated bovine MDBK cells. Colforsin 170-179 insulin like growth factor binding protein 2 Homo sapiens 42-47 9263910-9 1997 NPY (0.1 microM) inhibited the responses to 1 microM forskolin, but did not alter the stable hyperpolarization elicited by the specific activator of protein kinase A (PKA) SP-5,6-DCl-cBIMPS (0.1 mM). Colforsin 53-62 neuropeptide Y Rattus norvegicus 0-3 9228061-3 1997 Based on the three-dimensional structure of C2.forskolin dimer, these three regions (C2 alpha2, C2 alpha3/beta4, and C1 beta1) are close together and form a negatively charged and hydrophobic groove the width of an alpha helix that can accommodate the positively charged adenylyl cyclase binding region of Gsalpha. Colforsin 47-56 tubulin beta 3 class III Homo sapiens 99-111 9228061-3 1997 Based on the three-dimensional structure of C2.forskolin dimer, these three regions (C2 alpha2, C2 alpha3/beta4, and C1 beta1) are close together and form a negatively charged and hydrophobic groove the width of an alpha helix that can accommodate the positively charged adenylyl cyclase binding region of Gsalpha. Colforsin 47-56 GNAS complex locus Homo sapiens 306-313 9272681-0 1997 Regulation of stimulatory adenylyl cyclase signaling during forskolin-induced differentiation of mouse neuroblastoma x rat glioma (NG108-15) cells. Colforsin 60-69 Rho guanine nucleotide exchange factor (GEF) 16 Mus musculus 103-116 9286080-0 1997 D-Glucose, forskolin and cytochalasin B affinities for the glucose transporter Glut1. Colforsin 11-20 solute carrier family 2 member 1 Homo sapiens 79-84 9286080-2 1997 The affinities of D-glucose and the transport inhibitors, forskolin and cytochalasin B (CB), for Glut1 were studied by frontal affinity chromatography at pH 5-10 on sterically immobilized proteoliposomes with reconstituted human red cell glucose transporter Glut1. Colforsin 58-67 solute carrier family 2 member 1 Homo sapiens 97-102 9218443-2 1997 Using primary cultures of rat astroglial cells as a model system, we demonstrate that the mRNA for the type II iodothyronine deiodinase (DII) selenoenzyme is rapidly and markedly induced by forskolin and 8-bromo-cAMP. Colforsin 190-199 iodothyronine deiodinase 2 Rattus norvegicus 103-135 9263910-16 1997 However, the blocking effect of NPY on forskolin-elicited hyperpolarization was not affected by gadolinium. Colforsin 39-48 neuropeptide Y Rattus norvegicus 32-35 9263910-10 1997 Forskolin increased the cyclic AMP (cAMP) content of the arteries 21-fold, and NPY inhibited the forskolin-evoked increase in cAMP levels by 91%. Colforsin 97-106 neuropeptide Y Rattus norvegicus 79-82 9214454-6 1997 Forskolin, which stimulates adenylate cyclase activity, increased cAMP and PCK mRNA levels 1.6-fold and fivefold, respectively. Colforsin 0-9 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 75-78 9223428-5 1997 The increase was also induced by treatment with forskolin but not in the presence of cycloheximide, indicating that the TSH effect on Ref-1 mRNA is mediated by intracellular cAMP and requires de novo protein synthesis. Colforsin 48-57 apurinic/apyrimidinic endodeoxyribonuclease 1 Rattus norvegicus 134-139 9249506-3 1997 Treatment of smooth muscle cells with the membrane-permeable cAMP derivative dibutyryl cAMP or with compounds that increase intracellular cAMP levels (isoproterenol and forskolin) resulted in a concentration- and time-dependent increase in the levels of HO-1 mRNA and protein, whereas the expression of HO-2 remained unchanged. Colforsin 169-178 cathelicidin antimicrobial peptide Rattus norvegicus 61-65 9249506-3 1997 Treatment of smooth muscle cells with the membrane-permeable cAMP derivative dibutyryl cAMP or with compounds that increase intracellular cAMP levels (isoproterenol and forskolin) resulted in a concentration- and time-dependent increase in the levels of HO-1 mRNA and protein, whereas the expression of HO-2 remained unchanged. Colforsin 169-178 cathelicidin antimicrobial peptide Rattus norvegicus 87-91 9249506-3 1997 Treatment of smooth muscle cells with the membrane-permeable cAMP derivative dibutyryl cAMP or with compounds that increase intracellular cAMP levels (isoproterenol and forskolin) resulted in a concentration- and time-dependent increase in the levels of HO-1 mRNA and protein, whereas the expression of HO-2 remained unchanged. Colforsin 169-178 cathelicidin antimicrobial peptide Rattus norvegicus 87-91 9249506-3 1997 Treatment of smooth muscle cells with the membrane-permeable cAMP derivative dibutyryl cAMP or with compounds that increase intracellular cAMP levels (isoproterenol and forskolin) resulted in a concentration- and time-dependent increase in the levels of HO-1 mRNA and protein, whereas the expression of HO-2 remained unchanged. Colforsin 169-178 heme oxygenase 1 Rattus norvegicus 254-258 9249506-3 1997 Treatment of smooth muscle cells with the membrane-permeable cAMP derivative dibutyryl cAMP or with compounds that increase intracellular cAMP levels (isoproterenol and forskolin) resulted in a concentration- and time-dependent increase in the levels of HO-1 mRNA and protein, whereas the expression of HO-2 remained unchanged. Colforsin 169-178 heme oxygenase 2 Rattus norvegicus 303-307 9221900-2 1997 Exposure of the cells to compounds that increase cAMP levels (forskolin, forskolin + IBMX, or dibutyryl cAMP) resulted in the attenuation of ethanol-induced up-regulation of DOR mRNA. Colforsin 62-71 opioid receptor, delta 1 Mus musculus 174-177 9221900-2 1997 Exposure of the cells to compounds that increase cAMP levels (forskolin, forskolin + IBMX, or dibutyryl cAMP) resulted in the attenuation of ethanol-induced up-regulation of DOR mRNA. Colforsin 73-82 opioid receptor, delta 1 Mus musculus 174-177 9221900-4 1997 Northern blot analysis of RNA extracts from ethanol-, forskolin- or ethanol + forskolin-treated cells showed proportional changes in each of the multiple DOR mRNA bands, so that no difference was observed in the fraction of the total hybridization signal produced by each band of the DOR mRNA. Colforsin 54-63 opioid receptor, delta 1 Mus musculus 154-157 9221900-4 1997 Northern blot analysis of RNA extracts from ethanol-, forskolin- or ethanol + forskolin-treated cells showed proportional changes in each of the multiple DOR mRNA bands, so that no difference was observed in the fraction of the total hybridization signal produced by each band of the DOR mRNA. Colforsin 78-87 opioid receptor, delta 1 Mus musculus 154-157 9221900-4 1997 Northern blot analysis of RNA extracts from ethanol-, forskolin- or ethanol + forskolin-treated cells showed proportional changes in each of the multiple DOR mRNA bands, so that no difference was observed in the fraction of the total hybridization signal produced by each band of the DOR mRNA. Colforsin 78-87 opioid receptor, delta 1 Mus musculus 284-287 9221900-5 1997 In the absence of ethanol, forskolin or dibutyryl cAMP reduced the basal levels of DOR mRNA. Colforsin 27-36 opioid receptor, delta 1 Mus musculus 83-86 9207273-8 1997 IFN-gamma and IL-10 both separately reduced peak forskolin and carbachol-stimulated Isc. Colforsin 49-58 interferon gamma Homo sapiens 0-9 9207273-8 1997 IFN-gamma and IL-10 both separately reduced peak forskolin and carbachol-stimulated Isc. Colforsin 49-58 interleukin 10 Homo sapiens 14-19 9207273-11 1997 In addition, both IL-10 and IFN-gamma limit carbachol and forskolin-induced increase in Isc. Colforsin 58-67 interleukin 10 Homo sapiens 18-23 9207273-11 1997 In addition, both IL-10 and IFN-gamma limit carbachol and forskolin-induced increase in Isc. Colforsin 58-67 interferon gamma Homo sapiens 28-37 9214454-7 1997 However, IL-6 attenuated the forskolin-stimulated increase in PCK mRNA but not the increase in cAMP. Colforsin 29-38 interleukin 6 Rattus norvegicus 9-13 9214454-7 1997 However, IL-6 attenuated the forskolin-stimulated increase in PCK mRNA but not the increase in cAMP. Colforsin 29-38 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 62-65 9219156-5 1997 The addition of isoproterenol or forskolin further enhanced the stimulatory effect of pRSV/ CREB on the expression of pOGH (ANG N-1498/+18). Colforsin 33-42 cAMP responsive element binding protein 1 Homo sapiens 92-96 9202330-3 1997 Pre- and coinfusions of baclofen for 80 min had no effect on the basal efflux of cAMP from the striatum but induced a significant decrease of forskolin (10 microM)-stimulated cAMP efflux from the striatum in a dose-dependent manner. Colforsin 142-151 cathelicidin antimicrobial peptide Rattus norvegicus 175-179 9207925-5 1997 Anti-IGF-I antibody (3 micrograms/ml) significantly blocked osteoclastlike cell formation stimulated by 10(-4) M dbcAMP, 10(-4) M Sp-cAMPS, a direct PKA activator, and 10(-5) M forskolin in mouse bone cell cultures. Colforsin 177-186 insulin-like growth factor 1 Mus musculus 5-10 9207925-6 1997 Dibutyryl cAMP, forskolin, and hPTH-(1-34) significantly stimulated mRNA expression of both IGF-I and IGF-binding protein 5 (IGFBP-5) in these cultures, but neither 10(-7) M PMA, a PKC activator, nor 10(-7) M A23187 did. Colforsin 16-25 insulin-like growth factor 1 Mus musculus 92-97 9207925-6 1997 Dibutyryl cAMP, forskolin, and hPTH-(1-34) significantly stimulated mRNA expression of both IGF-I and IGF-binding protein 5 (IGFBP-5) in these cultures, but neither 10(-7) M PMA, a PKC activator, nor 10(-7) M A23187 did. Colforsin 16-25 insulin-like growth factor binding protein 5 Mus musculus 102-123 9207925-6 1997 Dibutyryl cAMP, forskolin, and hPTH-(1-34) significantly stimulated mRNA expression of both IGF-I and IGF-binding protein 5 (IGFBP-5) in these cultures, but neither 10(-7) M PMA, a PKC activator, nor 10(-7) M A23187 did. Colforsin 16-25 insulin-like growth factor binding protein 5 Mus musculus 125-132 9202330-2 1997 Addition of forskolin, an activator of adenylate cyclase, to perfusate for 20 min resulted in a dose-dependent increase of cAMP efflux from the striatum. Colforsin 12-21 cathelicidin antimicrobial peptide Rattus norvegicus 123-127 9202330-4 1997 SKF 97541 (100 microM), a GABA(B) receptor agonist, and GABA (50 microM) also decreased forskolin-induced cAMP efflux from the striatum. Colforsin 88-97 cathelicidin antimicrobial peptide Rattus norvegicus 106-110 9202330-5 1997 Coinfusion of CGP 54626A (100 microM), a GABA(B) receptor antagonist, counteracted the effect of baclofen on the forskolin-stimulated cAMP efflux. Colforsin 113-122 cathelicidin antimicrobial peptide Rattus norvegicus 134-138 9245567-10 1997 Pretreatment with isoproterenol and forskolin yielded superoxide generation of 3.2 +/- 0.6 and 3.1 +/- 1.2 nmole/2.5 x 10(5) PMN/min compared to 9.0 +/- 0.6 nmole/2.5 x 10(5) PMN/min for PAF/fMLP alone, whereas isoproterenol and forskolin did not significantly affect PAF-mediated neutrophil elastase release, 22.4 +/- 5.3 and 24.0 +/- 3.6%, respectively, compared to 39.4 +/- 9.1% for PAF/fMLP alone. Colforsin 36-45 formyl peptide receptor 1 Homo sapiens 390-394 9245567-10 1997 Pretreatment with isoproterenol and forskolin yielded superoxide generation of 3.2 +/- 0.6 and 3.1 +/- 1.2 nmole/2.5 x 10(5) PMN/min compared to 9.0 +/- 0.6 nmole/2.5 x 10(5) PMN/min for PAF/fMLP alone, whereas isoproterenol and forskolin did not significantly affect PAF-mediated neutrophil elastase release, 22.4 +/- 5.3 and 24.0 +/- 3.6%, respectively, compared to 39.4 +/- 9.1% for PAF/fMLP alone. Colforsin 36-45 PCNA clamp associated factor Homo sapiens 187-190 9207173-5 1997 In agreement with the effect on filamentous actin (F-actin) forskolin and IBMX markedly suppressed the migration of granulocytes towards fMLP. Colforsin 60-69 formyl peptide receptor 1 Homo sapiens 137-141 9245567-10 1997 Pretreatment with isoproterenol and forskolin yielded superoxide generation of 3.2 +/- 0.6 and 3.1 +/- 1.2 nmole/2.5 x 10(5) PMN/min compared to 9.0 +/- 0.6 nmole/2.5 x 10(5) PMN/min for PAF/fMLP alone, whereas isoproterenol and forskolin did not significantly affect PAF-mediated neutrophil elastase release, 22.4 +/- 5.3 and 24.0 +/- 3.6%, respectively, compared to 39.4 +/- 9.1% for PAF/fMLP alone. Colforsin 36-45 formyl peptide receptor 1 Homo sapiens 191-195 9245567-10 1997 Pretreatment with isoproterenol and forskolin yielded superoxide generation of 3.2 +/- 0.6 and 3.1 +/- 1.2 nmole/2.5 x 10(5) PMN/min compared to 9.0 +/- 0.6 nmole/2.5 x 10(5) PMN/min for PAF/fMLP alone, whereas isoproterenol and forskolin did not significantly affect PAF-mediated neutrophil elastase release, 22.4 +/- 5.3 and 24.0 +/- 3.6%, respectively, compared to 39.4 +/- 9.1% for PAF/fMLP alone. Colforsin 36-45 PCNA clamp associated factor Homo sapiens 268-271 9245567-10 1997 Pretreatment with isoproterenol and forskolin yielded superoxide generation of 3.2 +/- 0.6 and 3.1 +/- 1.2 nmole/2.5 x 10(5) PMN/min compared to 9.0 +/- 0.6 nmole/2.5 x 10(5) PMN/min for PAF/fMLP alone, whereas isoproterenol and forskolin did not significantly affect PAF-mediated neutrophil elastase release, 22.4 +/- 5.3 and 24.0 +/- 3.6%, respectively, compared to 39.4 +/- 9.1% for PAF/fMLP alone. Colforsin 36-45 PCNA clamp associated factor Homo sapiens 268-271 9212055-6 1997 Agonist stimulation of Mel1c(alpha) receptor was associated with the inhibition of cAMP accumulation stimulated by forskolin (IC50 approximately 10(-10) M) in HeLa, Ltk-, and human embryonic kidney 293 (HEK 293) cells. Colforsin 115-124 clone X2.0 melatonin receptor L homeolog Xenopus laevis 23-28 9212055-6 1997 Agonist stimulation of Mel1c(alpha) receptor was associated with the inhibition of cAMP accumulation stimulated by forskolin (IC50 approximately 10(-10) M) in HeLa, Ltk-, and human embryonic kidney 293 (HEK 293) cells. Colforsin 115-124 leukocyte receptor tyrosine kinase Homo sapiens 165-168 10072925-5 1997 DL111-IT 3 mg.L-1 also inhibited the stimulatory effect of forskolin (cAMP activator) 10 mumol.L-1 and pregnenolone [converted to progesterone by 3 beta-hydroxysteroid dehydrogenase-isomerase complex (3 beta-HSD)] 10 mumol.L-1 on progesterone production in cultured LC, and their inhibitory rates were 43% and 155%, respectively. Colforsin 59-68 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Rattus norvegicus 201-211 9207173-3 1997 Elevation of cAMP by exposure to forskolin (100 microM) and 1-isobutyl-methylxanthine (IBMX; 100 microM) caused a marked reduction in beta2 integrin-induced polymerisation of actin, but had a less pronounced effect on the fMLP-induced actin response. Colforsin 33-42 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 134-139 9207173-3 1997 Elevation of cAMP by exposure to forskolin (100 microM) and 1-isobutyl-methylxanthine (IBMX; 100 microM) caused a marked reduction in beta2 integrin-induced polymerisation of actin, but had a less pronounced effect on the fMLP-induced actin response. Colforsin 33-42 formyl peptide receptor 1 Homo sapiens 222-226 9224819-6 1997 When Asp114 in transmembrane 2 of MOR was converted to alanine, the ability was abolished of DAMGO or morphine to inhibit forskolin-stimulated [3H]cAMP production in Neuro2A cells stably expressing this mutant receptor. Colforsin 122-131 opioid receptor, mu 1 Mus musculus 34-37 9195972-0 1997 The rat D4 dopamine receptor couples to cone transducin (Galphat2) to inhibit forskolin-stimulated cAMP accumulation. Colforsin 78-87 dopamine receptor D4 Rattus norvegicus 8-28 9195972-0 1997 The rat D4 dopamine receptor couples to cone transducin (Galphat2) to inhibit forskolin-stimulated cAMP accumulation. Colforsin 78-87 guanine nucleotide binding protein, alpha transducing 1 Mus musculus 45-55 9256163-4 1997 Forskolin (10 microM), an activator of adenylyl cyclase, and terbutaline (100 microM), a beta2-adrenergic agonist known to increase cAMP levels, also increased renin mRNA and prorenin release. Colforsin 0-9 renin Homo sapiens 160-165 9226413-1 1997 The diterpene forskolin inhibits nicotine-evoked chromaffin cell Ca2+ influx, scinderin redistribution, F-actin disassembly and catecholamine secretion in a concentration-dependent (10-50 microM) fashion. Colforsin 14-23 scinderin Homo sapiens 78-87 9199185-2 1997 A synthetic glucocorticoid dexamethasone (100 nM) potently suppressed forskolin-induced cAMP generation, adrenocorticotropin (ACTH) secretion, and proopiomelanocortin gene expression. Colforsin 70-79 pro-opiomelanocortin-alpha Mus musculus 147-166 9199208-3 1997 Transfection of these cells with biglycan promoter luciferase reporter fusion genes and subsequent treatment with forskolin or the cAMP analog 8-Bromo-cAMP resulted in an up to 3.8-fold stimulation of biglycan promoter activity. Colforsin 114-123 biglycan Homo sapiens 201-209 9199208-5 1997 Up-regulation of transcription is also reflected at the level of mRNA expression, since biglycan mRNA steady state levels in MG-63 cells increased approximately 2-fold after 24 hours of forskolin treatment. Colforsin 186-195 biglycan Homo sapiens 88-96 9196057-8 1997 Interestingly, forskolin, which increased intracellular cAMP levels, significantly inhibited MAP kinase activation by GIP, but did not affect MAP kinase activation by GIP in the presence of wortmannin, suggesting that the wortmannin-sensitive pathway activates an MAP kinase cascade at or above the level of Raf-1 and that the wortmannin-insensitive pathway activates an MAP kinase cascade below the level of Raf-1. Colforsin 15-24 gastric inhibitory polypeptide Cricetulus griseus 118-121 9182531-2 1997 Addition of forskolin or prostaglandin E1, agents known to elevate platelet cAMP and calcium efflux, to platelets pre-labeled with [32P]PO4 resulted in the direct phosphorylation of platelet PMCA. Colforsin 12-21 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 191-195 9196057-8 1997 Interestingly, forskolin, which increased intracellular cAMP levels, significantly inhibited MAP kinase activation by GIP, but did not affect MAP kinase activation by GIP in the presence of wortmannin, suggesting that the wortmannin-sensitive pathway activates an MAP kinase cascade at or above the level of Raf-1 and that the wortmannin-insensitive pathway activates an MAP kinase cascade below the level of Raf-1. Colforsin 15-24 RAF proto-oncogene serine/threonine-protein kinase Cricetulus griseus 308-313 9196057-8 1997 Interestingly, forskolin, which increased intracellular cAMP levels, significantly inhibited MAP kinase activation by GIP, but did not affect MAP kinase activation by GIP in the presence of wortmannin, suggesting that the wortmannin-sensitive pathway activates an MAP kinase cascade at or above the level of Raf-1 and that the wortmannin-insensitive pathway activates an MAP kinase cascade below the level of Raf-1. Colforsin 15-24 RAF proto-oncogene serine/threonine-protein kinase Cricetulus griseus 409-414 9196070-5 1997 Our results show that somatostatin, in a concentration-dependent manner, inhibited basal and forskolin-stimulated interleukin 6 release from rat cortical type I astrocytes in culture. Colforsin 93-102 somatostatin Rattus norvegicus 22-34 9196070-5 1997 Our results show that somatostatin, in a concentration-dependent manner, inhibited basal and forskolin-stimulated interleukin 6 release from rat cortical type I astrocytes in culture. Colforsin 93-102 interleukin 6 Rattus norvegicus 114-127 9196070-9 1997 In our experimental conditions somatostatin significantly inhibited both basal and forskolin-stimulated cAMP accumulation. Colforsin 83-92 somatostatin Rattus norvegicus 31-43 9227644-8 1997 However, after stimulation with vasopressin or forskolin, the cellular distribution of S256A-AQP2 remained unchanged. Colforsin 47-56 aquaporin 2 Sus scrofa 93-97 9261564-4 1997 Stimulation with ORL1 specific agonist, nociceptin/orphanin FQ, increased [35S]GTP gamma S binding to SK-N-SH cell membranes (EC50 = 14 +/- 0.45 nM), and attenuated forskolin-stimulated accumulation of cellular cAMP (EC50 = 0.80 +/- 0.45 nM), indicative that activation of ORL1 activates G proteins and inhibits adenylyl cyclase. Colforsin 165-174 opioid related nociceptin receptor 1 Homo sapiens 17-21 9179387-21 1997 The adenylyl cyclase activator forskolin (100 microM, P < 0.01) also stimulated the release of ir-CRH-41, producing effects which were additive with those of rolipram and denbufylline but not with those of BRL 61063. Colforsin 31-40 corticotropin releasing hormone Rattus norvegicus 101-104 9191094-2 1997 In catecholaminergic cells, the expression of TH-mRNA is up-regulated by forskolin (FK) and is suppressed by retinoic acid (RA). Colforsin 73-82 tyrosine hydroxylase Rattus norvegicus 46-48 9177393-9 1997 The repressive action of TSH on the effects of TPA and EGF mRNA were mimicked by forskolin and 8-bromo-cAMP, suggesting that the TSH inhibitory action is PKA mediated. Colforsin 81-90 epidermal growth factor Homo sapiens 55-58 9165044-3 1997 Treatment of L6E9 myotubes with 8-bromo-cAMP, forskolin, or monobutyryl-8-bromo-cAMP led to a marked decrease in GLUT4 protein levels; 8-bromo-cAMP also diminished GLUT4 messenger RNA (mRNA), suggesting pretranslational repression. Colforsin 46-55 solute carrier family 2 member 4 Rattus norvegicus 113-118 9165044-3 1997 Treatment of L6E9 myotubes with 8-bromo-cAMP, forskolin, or monobutyryl-8-bromo-cAMP led to a marked decrease in GLUT4 protein levels; 8-bromo-cAMP also diminished GLUT4 messenger RNA (mRNA), suggesting pretranslational repression. Colforsin 46-55 solute carrier family 2 member 4 Rattus norvegicus 164-169 9165044-4 1997 In contrast, L6E9 myoblasts and myotubes responded to 8-bromo-cAMP or forskolin by increasing the cell content of GLUT1 protein. Colforsin 70-79 solute carrier family 2 member 1 Rattus norvegicus 114-119 9180634-9 1997 8-Bromo-cAMP, a cAMP analogue, and forskolin, an activator of adenylate cyclase, inhibited the Ang II-induced SMC migration. Colforsin 35-44 angiotensinogen Homo sapiens 95-101 9169347-5 1997 Agonists for protein kinase A (PKA) (forskolin), and protein kinase C (PKC) (phorbol 12-myristate 13-acetate; PMA) also stimulated IL-6/IL-11 production. Colforsin 37-46 interleukin 6 Homo sapiens 131-135 9169347-5 1997 Agonists for protein kinase A (PKA) (forskolin), and protein kinase C (PKC) (phorbol 12-myristate 13-acetate; PMA) also stimulated IL-6/IL-11 production. Colforsin 37-46 interleukin 11 Homo sapiens 136-141 9165004-5 1997 This effect of IGF-I and EGF was not inhibited by increased intracellular cAMP generated by pretreatment of the cells with 10 microM forskolin. Colforsin 133-142 insulin like growth factor 1 Homo sapiens 15-20 9165004-10 1997 Pretreatment of cells with 10 microM forskolin decreased IGF-I- and EGF-stimulated luciferase activity by approximately 75%. Colforsin 37-46 insulin like growth factor 1 Homo sapiens 57-62 9165004-10 1997 Pretreatment of cells with 10 microM forskolin decreased IGF-I- and EGF-stimulated luciferase activity by approximately 75%. Colforsin 37-46 epidermal growth factor Homo sapiens 68-71 9191599-15 1997 Although forskolin (5 microM), an adenylate cyclase activator, also upregulated the level of bFGF mRNA, the effects of forskolin and bFGF were additive. Colforsin 9-18 fibroblast growth factor 2 Rattus norvegicus 93-97 9191599-15 1997 Although forskolin (5 microM), an adenylate cyclase activator, also upregulated the level of bFGF mRNA, the effects of forskolin and bFGF were additive. Colforsin 9-18 fibroblast growth factor 2 Rattus norvegicus 133-137 9191599-15 1997 Although forskolin (5 microM), an adenylate cyclase activator, also upregulated the level of bFGF mRNA, the effects of forskolin and bFGF were additive. Colforsin 119-128 fibroblast growth factor 2 Rattus norvegicus 93-97 9223076-3 1997 N/OFQ stimulation increased [35S]GTP gamma S binding to cell membranes and attenuated forskolin-induced cAMP accumulation in a concentration-dependent manner. Colforsin 86-95 prepronociceptin Homo sapiens 0-5 9166715-3 1997 In the presence of 40 microM H-89, mRNA levels of TH, DBH, and PNMT were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. At 20 microM, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%. Colforsin 380-389 tyrosine hydroxylase Bos taurus 50-52 9166715-3 1997 In the presence of 40 microM H-89, mRNA levels of TH, DBH, and PNMT were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. At 20 microM, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%. Colforsin 380-389 phenylethanolamine N-methyltransferase Bos taurus 63-67 9166719-8 1997 SRIF-14 and octreotide inhibited forskolin-stimulated adenylyl cyclase activity in neurons and glia, whereas CH-275 was effective in neurons only. Colforsin 33-42 somatostatin Mus musculus 0-4 9197282-2 1997 The transcript levels of the four subunit genes of the nAChR (alpha3, alpha5, alpha7, and beta4) were down-regulated by the treatment with forskolin, whereas the mRNA levels of the TH gene was increased in PC12 cells. Colforsin 139-148 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 55-60 9197282-3 1997 By long-term nicotine treatment, the mRNA level of the nAChR genes did not change, but transcript levels of alpha3, alpha5, alpha7, and beta4 nAChR genes were still negatively regulated by forskolin. Colforsin 189-198 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 142-147 9182807-6 1997 In addition, ASIP blocked the stimulatory effects of forskolin or dibutyryl cAMP, agents that act downstream from the MC1R, on tyrosinase activity and cell proliferation. Colforsin 53-62 nonagouti Mus musculus 13-17 9182807-6 1997 In addition, ASIP blocked the stimulatory effects of forskolin or dibutyryl cAMP, agents that act downstream from the MC1R, on tyrosinase activity and cell proliferation. Colforsin 53-62 melanocortin 1 receptor Mus musculus 118-122 9182807-6 1997 In addition, ASIP blocked the stimulatory effects of forskolin or dibutyryl cAMP, agents that act downstream from the MC1R, on tyrosinase activity and cell proliferation. Colforsin 53-62 tyrosinase Homo sapiens 127-137 9182808-13 1997 Our results indicate that keratolinin is identical with cystatin A, a cysteine proteinase inhibitor, and its expression is positively regulated by Ca2+, TPA, and forskolin. Colforsin 162-171 cystatin A Homo sapiens 56-66 9166752-4 1997 Activation and inhibition of PKA were carried out by means of forskolin and the PKA inhibitory peptide (PKA-IP), respectively. Colforsin 62-71 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 29-32 9241755-4 1997 vWf release increased by 50% in response to forskolin, which activates adenylate cyclase. Colforsin 44-53 von Willebrand factor Homo sapiens 0-3 9241755-11 1997 We found a close correlation between cellular cAMP content and vWf release after stimulation with epinephrine and forskolin. Colforsin 114-123 von Willebrand factor Homo sapiens 63-66 9194575-3 1997 Thrombin (0.001-0.25 U/ml) dose-dependently inhibited IBMX-, isoproterenol- and forskolin-stimulated cAMP accumulation. Colforsin 80-89 coagulation factor II Rattus norvegicus 0-8 9223097-3 1997 In contrast, both beta-adrenoceptor- and forskolin-stimulated adenylyl cyclase activities were significantly increased in fibroblasts bearing PS1 M146V and PS1 H163Y mutations compared with controls (p < 0.01 and p < 0.05, respectively). Colforsin 41-50 presenilin 1 Homo sapiens 142-145 9223097-3 1997 In contrast, both beta-adrenoceptor- and forskolin-stimulated adenylyl cyclase activities were significantly increased in fibroblasts bearing PS1 M146V and PS1 H163Y mutations compared with controls (p < 0.01 and p < 0.05, respectively). Colforsin 41-50 presenilin 1 Homo sapiens 156-159 9133371-3 1997 Although glutamate, dopamine, and forskolin (an activator of adenylate cyclase) all induce c-fos mRNA and AP-1 binding, we found, surprisingly, that only glutamate induces transcription of a transfected AP-1-driven fusion gene. Colforsin 34-43 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 91-96 9188860-2 1997 We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-induced cell death that was always accompanied by selective downregulation of the nuclear levels of NF-kappa B p65-p50 (RelA-p50) transcription factor. Colforsin 119-128 CD244 molecule Homo sapiens 34-37 9188860-2 1997 We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-induced cell death that was always accompanied by selective downregulation of the nuclear levels of NF-kappa B p65-p50 (RelA-p50) transcription factor. Colforsin 119-128 BCL2 apoptosis regulator Homo sapiens 86-91 9188860-2 1997 We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-induced cell death that was always accompanied by selective downregulation of the nuclear levels of NF-kappa B p65-p50 (RelA-p50) transcription factor. Colforsin 119-128 nuclear factor kappa B subunit 1 Homo sapiens 313-323 9188860-2 1997 We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-induced cell death that was always accompanied by selective downregulation of the nuclear levels of NF-kappa B p65-p50 (RelA-p50) transcription factor. Colforsin 119-128 RELA proto-oncogene, NF-kB subunit Homo sapiens 324-327 9188860-2 1997 We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-induced cell death that was always accompanied by selective downregulation of the nuclear levels of NF-kappa B p65-p50 (RelA-p50) transcription factor. Colforsin 119-128 nuclear factor kappa B subunit 1 Homo sapiens 328-331 9188860-2 1997 We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-induced cell death that was always accompanied by selective downregulation of the nuclear levels of NF-kappa B p65-p50 (RelA-p50) transcription factor. Colforsin 119-128 nuclear factor kappa B subunit 1 Homo sapiens 338-341 9188860-3 1997 Forskolin not only inhibited activation-induced cell death and NF-kappa B activation, but also suppressed expression of Fas and Fas ligand (Fas-L). Colforsin 0-9 nuclear factor kappa B subunit 1 Homo sapiens 63-73 9188860-3 1997 Forskolin not only inhibited activation-induced cell death and NF-kappa B activation, but also suppressed expression of Fas and Fas ligand (Fas-L). Colforsin 0-9 Fas ligand Homo sapiens 128-138 9188860-3 1997 Forskolin not only inhibited activation-induced cell death and NF-kappa B activation, but also suppressed expression of Fas and Fas ligand (Fas-L). Colforsin 0-9 Fas ligand Homo sapiens 140-145 9196288-4 1997 Significant levels of prolactin (PRL), growth hormone and luteinizing hormone were present in the culture media after several weeks in vitro and PRL release could be modulated by dopaminergic agonists or forskolin. Colforsin 204-213 prolactin Rattus norvegicus 22-31 9196288-4 1997 Significant levels of prolactin (PRL), growth hormone and luteinizing hormone were present in the culture media after several weeks in vitro and PRL release could be modulated by dopaminergic agonists or forskolin. Colforsin 204-213 prolactin Rattus norvegicus 145-148 9133371-3 1997 Although glutamate, dopamine, and forskolin (an activator of adenylate cyclase) all induce c-fos mRNA and AP-1 binding, we found, surprisingly, that only glutamate induces transcription of a transfected AP-1-driven fusion gene. Colforsin 34-43 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 106-110 9133371-3 1997 Although glutamate, dopamine, and forskolin (an activator of adenylate cyclase) all induce c-fos mRNA and AP-1 binding, we found, surprisingly, that only glutamate induces transcription of a transfected AP-1-driven fusion gene. Colforsin 34-43 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 203-207 28715099-0 1997 Forskolin Delays the Ethanol-Induced Desensitization of Hypothalamic beta-Endorphin Neurons in Primary Cultures. Colforsin 0-9 proopiomelanocortin Homo sapiens 69-83 9214688-3 1997 In both whole cells and membranes, genistein also inhibited cAMP produced in response to direct stimulation of adenylyl cyclase with forskolin. Colforsin 133-142 cathelicidin antimicrobial peptide Mus musculus 60-64 9214688-7 1997 Another tyrosine kinase inhibitor, herbimycin A, which inhibits by a different mechanism than genistein, also decreased forskolin-stimulated cAMP in whole cells. Colforsin 120-129 cathelicidin antimicrobial peptide Mus musculus 141-145 9214688-8 1997 As would be expected for the involvement of tyrosine phosphorylation in the control of cAMP production, inhibition of tyrosine phosphatases by vandate increased forskolin-stimulated cAMP production. Colforsin 161-170 cathelicidin antimicrobial peptide Mus musculus 87-91 9214688-8 1997 As would be expected for the involvement of tyrosine phosphorylation in the control of cAMP production, inhibition of tyrosine phosphatases by vandate increased forskolin-stimulated cAMP production. Colforsin 161-170 cathelicidin antimicrobial peptide Mus musculus 182-186 9144195-3 1997 Using COS7 cells transfected with human PS1, we have found that phorbol 12, 13-dibutyrate and forskolin increase the state of phosphorylation of serine residues of the human CTF. Colforsin 94-103 presenilin 1 Homo sapiens 40-43 9161608-0 1997 Forskolin delays the ethanol-induced desensitization of hypothalamic beta-endorphin neurons in primary cultures. Colforsin 0-9 proopiomelanocortin Homo sapiens 69-83 9161608-9 1997 Pretreatment of cultures with a cAMP analog, forskolin, increased the activity of functional beta-EP neurons and delayed the ethanol desensitization effects on these neurons. Colforsin 45-54 proopiomelanocortin Homo sapiens 93-100 9154331-11 1997 Both populations of cells were equally susceptible towards inhibition of TNF release by cyclic AMP elevating agents such as dibutyryl cyclic AMP, prostaglandin E2 (PGE2) or forskolin, which all led to a complete abrogation of TNF production in a concentration-dependent manner and which were more efficient than the glucocorticoid dexamethasone. Colforsin 173-182 tumor necrosis factor Homo sapiens 73-76 9157961-9 1997 Addition of forskolin (3 micromol/L) or dibutyryl cAMP (1 mmol/L) to macrophage cultures reproduced the oxLDL-mediated inhibition of PAF receptor expression; carbamyl PAF reduced PAF binding and PAF mRNA to a similar degree (approximately 50%). Colforsin 12-21 PCNA clamp associated factor Homo sapiens 133-136 9157961-9 1997 Addition of forskolin (3 micromol/L) or dibutyryl cAMP (1 mmol/L) to macrophage cultures reproduced the oxLDL-mediated inhibition of PAF receptor expression; carbamyl PAF reduced PAF binding and PAF mRNA to a similar degree (approximately 50%). Colforsin 12-21 PCNA clamp associated factor Homo sapiens 167-170 9157961-9 1997 Addition of forskolin (3 micromol/L) or dibutyryl cAMP (1 mmol/L) to macrophage cultures reproduced the oxLDL-mediated inhibition of PAF receptor expression; carbamyl PAF reduced PAF binding and PAF mRNA to a similar degree (approximately 50%). Colforsin 12-21 PCNA clamp associated factor Homo sapiens 167-170 9157961-9 1997 Addition of forskolin (3 micromol/L) or dibutyryl cAMP (1 mmol/L) to macrophage cultures reproduced the oxLDL-mediated inhibition of PAF receptor expression; carbamyl PAF reduced PAF binding and PAF mRNA to a similar degree (approximately 50%). Colforsin 12-21 PCNA clamp associated factor Homo sapiens 167-170 9154343-8 1997 Isoforms EP3I and EP3II showed concentration-dependent inhibition of forskolin-stimulated adenylyl cyclase in CHO-K1 cells by the EP3 receptor agonist, sulprostone. Colforsin 69-78 prostaglandin E receptor 3 Homo sapiens 9-13 9154343-8 1997 Isoforms EP3I and EP3II showed concentration-dependent inhibition of forskolin-stimulated adenylyl cyclase in CHO-K1 cells by the EP3 receptor agonist, sulprostone. Colforsin 69-78 prostaglandin E receptor 3 Homo sapiens 18-23 9154343-8 1997 Isoforms EP3I and EP3II showed concentration-dependent inhibition of forskolin-stimulated adenylyl cyclase in CHO-K1 cells by the EP3 receptor agonist, sulprostone. Colforsin 69-78 prostaglandin E receptor 3 (subtype EP3) Mus musculus 9-12 9154343-12 1997 Isoforms EP3III and EP3IV showed marked constitutive activity, inhibiting forskolin-stimulated adenylyl cyclase in the absence of agonist. Colforsin 74-83 prostaglandin E receptor 3 Homo sapiens 9-15 9154343-12 1997 Isoforms EP3III and EP3IV showed marked constitutive activity, inhibiting forskolin-stimulated adenylyl cyclase in the absence of agonist. Colforsin 74-83 prostaglandin E receptor 3 Homo sapiens 20-25 9154343-18 1997 Pertussis toxin reversed sulprostone-mediated inhibition of cyclic AMP formation in EP3I and EP3II and abolished constitutive activity of EP3III, EP3IV and T-359 so that the level of forskolin-stimulated cyclic AMP produced was the same in all cells and similar to that obtained in mock-transfected cells. Colforsin 183-192 prostaglandin E receptor 3 Homo sapiens 138-144 9154343-18 1997 Pertussis toxin reversed sulprostone-mediated inhibition of cyclic AMP formation in EP3I and EP3II and abolished constitutive activity of EP3III, EP3IV and T-359 so that the level of forskolin-stimulated cyclic AMP produced was the same in all cells and similar to that obtained in mock-transfected cells. Colforsin 183-192 prostaglandin E receptor 3 Homo sapiens 146-151 9133546-3 1997 The stimulatory actions of GLP-I(7-36) amide and GIP were mimicked by forskolin and antagonized by the protein kinase A (PKA)-inhibitor Rp-8-Br-cAMPS. Colforsin 70-79 granzyme B Rattus norvegicus 27-32 9133546-3 1997 The stimulatory actions of GLP-I(7-36) amide and GIP were mimicked by forskolin and antagonized by the protein kinase A (PKA)-inhibitor Rp-8-Br-cAMPS. Colforsin 70-79 gastric inhibitory polypeptide Rattus norvegicus 49-52 9112381-4 1997 In GH4C1 cells, activation of D4 receptor variants (D4.2, D4.4, and D4.7) resulted in a similar level of reduction in forskolin- and vasoactive intestinal peptide (VIP)-stimulated cAMP levels (33% and 50%, respectively). Colforsin 118-127 dopamine receptor D4 Homo sapiens 30-41 9112381-5 1997 In addition, the forskolin-stimulated activity of cAMP response elements fused to the VIP promoter driving the lacZ reporter gene could be blocked by D4 activation. Colforsin 17-26 vasoactive intestinal peptide Rattus norvegicus 86-89 9218133-9 1997 We conclude the PDGF induces the activation of p38MAPK, whereas forskolin elicits its dissociation from the complex with Ste20. Colforsin 64-73 serine/threonine kinase 24 Homo sapiens 121-126 9218135-7 1997 Forskolin stimulated the induction of the dual specific phosphatase MAP kinase phosphatase-1 (MKP-1), although this effect was small relative to levels induced by PDGF and angiotensin II. Colforsin 0-9 dual specificity phosphatase 1 Rattus norvegicus 68-92 9218135-7 1997 Forskolin stimulated the induction of the dual specific phosphatase MAP kinase phosphatase-1 (MKP-1), although this effect was small relative to levels induced by PDGF and angiotensin II. Colforsin 0-9 dual specificity phosphatase 1 Rattus norvegicus 94-99 9218135-8 1997 However, PDGF stimulated induction of MKP-1 was abolished by the protein kinase A inhibitor H89 and this correlated with the reversal of forskolin-mediated inhibition of PDGF-stimulated MAP kinase activity. Colforsin 137-146 dual specificity phosphatase 1 Rattus norvegicus 38-43 9187876-9 1997 Constitutive release of GM-CSF from cultured human gastric AGS cells could be significantly enhanced by co-culture with live H. pylori or the addition of interleukin-1 beta, tumour necrosis factor alpha and PMA, but not by exposure to forskolin. Colforsin 235-244 colony stimulating factor 2 Homo sapiens 24-30 9136078-8 1997 The activation of cAMP-dependent protein kinase, or protein kinase A, by the treatment of cells with forskolin or 8-BrcAMP augmented basal, tumor necrosis factor-alpha and A1F4(-)-induced [3H]inositol phosphate formation. Colforsin 101-110 tumor necrosis factor Homo sapiens 140-167 9141522-7 1997 As expected, ACTH, forskolin, and cAMP markedly increased the production of cortisol by 26-, 10-, and 13-fold, respectively, and that of DHEA-S by 5.4-, 4.6-, and 5.5-fold, respectively, compared with basal levels. Colforsin 19-28 sulfotransferase family 2A member 1 Homo sapiens 137-143 9141522-8 1997 IGF-II (100 ng/mL) significantly (P < 0.001) increased ACTH-, forskolin-, and cAMP-stimulated production of cortisol by 2.4-, 4.3-, and 3.2-fold, respectively, and that of DHEA-S by 1.4, 1.6-, and 1.4-fold, respectively. Colforsin 65-74 insulin like growth factor 2 Homo sapiens 0-6 9141522-9 1997 IGF-I (100 ng/mL) had similar effects as IGF-II and significantly (P < 0.001) increased ACTH-, forskolin-, and cAMP-stimulated production of cortisol by 2.8-, 3.9-, and 3.1-fold, respectively, and that of DHEA-S by 1.3-, 1.6-, and 1.4-fold, respectively. Colforsin 98-107 insulin like growth factor 1 Homo sapiens 0-5 9141522-9 1997 IGF-I (100 ng/mL) had similar effects as IGF-II and significantly (P < 0.001) increased ACTH-, forskolin-, and cAMP-stimulated production of cortisol by 2.8-, 3.9-, and 3.1-fold, respectively, and that of DHEA-S by 1.3-, 1.6-, and 1.4-fold, respectively. Colforsin 98-107 insulin like growth factor 2 Homo sapiens 41-47 9109541-6 1997 The stimulatory effect was also observed after direct stimulation of the adenylyl cyclase with forskolin, indicating that VILIP acts downstream of receptor and G protein in the beta-adrenergic signaling pathway in C6 cells. Colforsin 95-104 visinin like 1 Homo sapiens 122-127 9109507-4 1997 Forskolin or dibutyryl cyclic AMP inhibited the increase in APPs secretion caused by metabotropic glutamate receptor agonists or by phorbol ester treatment but did not affect basal APPs levels. Colforsin 0-9 cathepsin B Homo sapiens 60-64 9175633-4 1997 Treatment of myometrial smooth muscle cells with analogs of PTH-rP caused an increase the intracellular levels of cAMP and treatment of myometrial cells with forskolin or dibutyryl cyclic AMP caused an increase in the levels of PTH-rP mRNAs. Colforsin 158-167 parathyroid hormone like hormone Homo sapiens 228-234 9165460-4 1997 NPY receptor function in the absence of or following RA treatment was determined by the ability of various concentrations of NPY to attenuate the forskolin-stimulated accumulation of intracellular cAMP. Colforsin 146-155 neuropeptide Y Homo sapiens 0-3 9165460-4 1997 NPY receptor function in the absence of or following RA treatment was determined by the ability of various concentrations of NPY to attenuate the forskolin-stimulated accumulation of intracellular cAMP. Colforsin 146-155 neuropeptide Y Homo sapiens 125-128 9165460-8 1997 The effect of forskolin was inhibited by NPY in a dose-dependent fashion in both untreated and treated cells indicating functional receptors in both NPY stimulates the growth of normal SK-N-MC cells. Colforsin 14-23 neuropeptide Y Homo sapiens 41-44 9165460-8 1997 The effect of forskolin was inhibited by NPY in a dose-dependent fashion in both untreated and treated cells indicating functional receptors in both NPY stimulates the growth of normal SK-N-MC cells. Colforsin 14-23 neuropeptide Y Homo sapiens 149-152 9111020-6 1997 Forskolin, an agent that elevates intracellular cAMP, rapidly inhibited processing of the 150-kDa isoform to the 135-kDa isoform and transport of eNOS to the sarcolemma, effects paralleled by protein kinase A-dependent phosphorylation of the larger eNOS isoform. Colforsin 0-9 nitric oxide synthase 3 Rattus norvegicus 146-150 9111020-6 1997 Forskolin, an agent that elevates intracellular cAMP, rapidly inhibited processing of the 150-kDa isoform to the 135-kDa isoform and transport of eNOS to the sarcolemma, effects paralleled by protein kinase A-dependent phosphorylation of the larger eNOS isoform. Colforsin 0-9 nitric oxide synthase 3 Rattus norvegicus 249-253 9145782-4 1997 The beta-adrenoceptor agonists, metaproterenol and isoproterenol, and other cAMP-elevating agents, such as glucagon, forskolin, and dibutyryl cAMP, potentiated both hepatocyte DNA synthesis and proliferation about 1.4-fold when cultured in combination with 20 ng/ml EGF. Colforsin 117-126 epidermal growth factor like 1 Rattus norvegicus 266-269 9172156-1 1997 Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons. Colforsin 170-179 fibroblast growth factor 1 Homo sapiens 71-102 9172156-1 1997 Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons. Colforsin 170-179 fibroblast growth factor 1 Homo sapiens 104-108 9172156-1 1997 Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons. Colforsin 170-179 tyrosine hydroxylase Homo sapiens 254-274 9172156-1 1997 Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons. Colforsin 170-179 tyrosine hydroxylase Homo sapiens 276-278 9172156-1 1997 Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons. Colforsin 170-179 tyrosine hydroxylase Homo sapiens 287-289 9150432-6 1997 In PC12 cells, forskolin elevated MSE activity several fold, and this induction was abolished in CRE mutants. Colforsin 15-24 enolase 3 Rattus norvegicus 34-37 9106486-6 1997 The interactions between D-glucose, the transport inhibitor forskolin and Glut1 were analyzed by quantitative frontal affinity chromatography. Colforsin 60-69 solute carrier family 2 member 1 Homo sapiens 74-79 9142872-5 1997 At low glucose, IAPP mRNA levels were increased 1.9-fold in islets treated with forskolin or dibutyryl adenosine 3",5"-cyclic monophosphate (DBcAMP) but not with 12-O-tetradecanoylphorbol 13-acetate. Colforsin 80-89 islet amyloid polypeptide Rattus norvegicus 16-20 9075801-7 1997 These effects of GLP-I and forskolin in the presence of GIP did not involve a change in the whole-cell Ca2+-current or [Ca2+]i. Colforsin 27-36 gastric inhibitory polypeptide Mus musculus 56-59 9075722-1 1997 The forskolin-induced steroidogenic block of testosterone production residing beyond pregnenolone synthesis in rat Leydig cells was localized to the level of the 17beta-hydroxysteroid dehydrogenase (17betaHSD) reaction in this study. Colforsin 4-13 aldo-keto reductase family 1, member C12 Rattus norvegicus 162-197 9137913-0 1997 Induction of tyrosine hydroxylase by forskolin: modulation with age. Colforsin 37-46 tyrosine hydroxylase Rattus norvegicus 13-33 9137913-6 1997 Forskolin at doses of 1.8 and 3.5 mg/kg increased tyrosine hydroxylase mRNA levels 2.5-fold in adrenal medulla from young rats but did not increase either tyrosine hydroxylase immunoreactivity or tyrosine hydroxylase enzyme activity 5 h after administration. Colforsin 0-9 tyrosine hydroxylase Rattus norvegicus 50-70 9137913-7 1997 Prolonged treatment with forskolin (3 doses, 12 h apart) increased tyrosine hydroxylase mRNA levels and tyrosine hydroxylase immunoreactivity and tyrosine hydroxylase enzyme activity. Colforsin 25-34 tyrosine hydroxylase Rattus norvegicus 67-87 9137913-7 1997 Prolonged treatment with forskolin (3 doses, 12 h apart) increased tyrosine hydroxylase mRNA levels and tyrosine hydroxylase immunoreactivity and tyrosine hydroxylase enzyme activity. Colforsin 25-34 tyrosine hydroxylase Rattus norvegicus 104-124 9137913-7 1997 Prolonged treatment with forskolin (3 doses, 12 h apart) increased tyrosine hydroxylase mRNA levels and tyrosine hydroxylase immunoreactivity and tyrosine hydroxylase enzyme activity. Colforsin 25-34 tyrosine hydroxylase Rattus norvegicus 104-124 9137913-9 1997 A single injection of the lower dose of forskolin increased tyrosine hydroxylase mRNA levels by the same increment in senescent as compared with young rats. Colforsin 40-49 tyrosine hydroxylase Rattus norvegicus 60-80 9140073-8 1997 Following treatment with forskolin, thapsigargin, or dexamethasone, the CRE binding protein (CREB) was phosphorylated at levels correlating with the level of induced gene expression. Colforsin 25-34 cAMP responsive element binding protein 1 Mus musculus 72-91 9140073-8 1997 Following treatment with forskolin, thapsigargin, or dexamethasone, the CRE binding protein (CREB) was phosphorylated at levels correlating with the level of induced gene expression. Colforsin 25-34 cAMP responsive element binding protein 1 Mus musculus 93-97 9142920-9 1997 Moreover, in CFTR(-/-) mice, both forskolin- and carbachol-stimulated peak HCO3- secretions were fourfold less compared with those in CFTR(+/+) littermates (3.7 +/- 0.2 vs. 15.6 +/- 2.1 and 4.7 +/- 0.3 vs. 14.2 +/- 2.5 micromol x cm(-1) x h(-1), respectively; P < 0.01). Colforsin 34-43 cystic fibrosis transmembrane conductance regulator Mus musculus 13-17 9173892-5 1997 Stimulation of AtT-20 cells with either forskolin or phorbol 12-myristate 13-acetate induces the secretion of wild-type CPE and of CPE lacking the pro region to similar extents, indicating a similar efficiency of sorting of the mutant. Colforsin 40-49 carboxypeptidase E Mus musculus 120-123 9173892-5 1997 Stimulation of AtT-20 cells with either forskolin or phorbol 12-myristate 13-acetate induces the secretion of wild-type CPE and of CPE lacking the pro region to similar extents, indicating a similar efficiency of sorting of the mutant. Colforsin 40-49 carboxypeptidase E Mus musculus 131-134 9075706-4 1997 We now show that, in Northern blot analyses, TSH-induced down-regulation of TSHR mRNA levels, which can be duplicated by forskolin and dibutylyl cAMP, i.e. which is cAMP-mediated. Colforsin 121-130 thyroid stimulating hormone receptor Rattus norvegicus 76-80 9075730-10 1997 Elevation of cAMP by forskolin exerted partial inhibition on EGF, but not on TPA or GnRH-a action, suggesting that MEK activators other than Raf-1 might be involved in GnRH action. Colforsin 21-30 midkine Mus musculus 115-118 9084443-5 1997 Both forms of PACAP, as well as forskolin, stimulated transcriptional induction of tyrosine hydroxylase (TH) and c-fos promoters fused to a chloramphenicol acetyltransferase (CAT) reporter gene in transiently transfected cells (p < 0.01 vs. controls). Colforsin 32-41 tyrosine hydroxylase Mus musculus 83-103 10495789-15 1997 Both forskolin and dexamethasone also reduced the amount of RANTES protein secreted by MC in response to aggr. Colforsin 5-14 chemokine (C-C motif) ligand 5 Mus musculus 60-66 9075734-5 1997 The effects of VIP and forskolin on PKC isozyme distribution could be blocked by pretreating cells with the PKA inhibitor rp-cAMP. Colforsin 23-32 protein kinase C, alpha Rattus norvegicus 36-39 9084443-5 1997 Both forms of PACAP, as well as forskolin, stimulated transcriptional induction of tyrosine hydroxylase (TH) and c-fos promoters fused to a chloramphenicol acetyltransferase (CAT) reporter gene in transiently transfected cells (p < 0.01 vs. controls). Colforsin 32-41 tyrosine hydroxylase Mus musculus 105-107 9084443-5 1997 Both forms of PACAP, as well as forskolin, stimulated transcriptional induction of tyrosine hydroxylase (TH) and c-fos promoters fused to a chloramphenicol acetyltransferase (CAT) reporter gene in transiently transfected cells (p < 0.01 vs. controls). Colforsin 32-41 FBJ osteosarcoma oncogene Mus musculus 113-118 9106622-3 1997 Acute incubation of NG108-15 cells with NMDA, a specific agonist of NMDA receptor, significantly attenuated the ability of DOR agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) to inhibit forskolin-stimulated cAMP production. Colforsin 182-191 opioid receptor, delta 1 Mus musculus 123-126 9365188-11 1997 However, removal of the serum or the addition of forskolin or phorbol ester (TPA) induced a rapid elevation of aromatase mRNA and the switching of aromatase transcripts to exon 1c in the cells, whereas TGFbeta almost abolished the expression of aromatase mRNA. Colforsin 49-58 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 111-120 9365188-11 1997 However, removal of the serum or the addition of forskolin or phorbol ester (TPA) induced a rapid elevation of aromatase mRNA and the switching of aromatase transcripts to exon 1c in the cells, whereas TGFbeta almost abolished the expression of aromatase mRNA. Colforsin 49-58 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 147-156 9365188-11 1997 However, removal of the serum or the addition of forskolin or phorbol ester (TPA) induced a rapid elevation of aromatase mRNA and the switching of aromatase transcripts to exon 1c in the cells, whereas TGFbeta almost abolished the expression of aromatase mRNA. Colforsin 49-58 transforming growth factor beta 1 Homo sapiens 202-209 9365188-11 1997 However, removal of the serum or the addition of forskolin or phorbol ester (TPA) induced a rapid elevation of aromatase mRNA and the switching of aromatase transcripts to exon 1c in the cells, whereas TGFbeta almost abolished the expression of aromatase mRNA. Colforsin 49-58 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 147-156 9365188-12 1997 Because co-culture of cancer cells such as MCF-7 increased aromatase mRNA of the cells cultured in the serum-containing medium, it is possible that cancer cells secret stimulatory factors acting like forskolin or TPA, or consume serum inhibitory factors acting like TGFbeta, consequently causing levels of aromatase mRNA to increase. Colforsin 200-209 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 59-68 9098861-7 1997 Maximal inhibition was observed with 30 microU/mL of insulin in the presence of either isoprenaline or forskolin. Colforsin 103-112 insulin Homo sapiens 53-60 9225266-1 1997 Inhibition of forskolin-stimulated cyclic AMP accumulation was measured in two stable HeLa cell lines HA6 and HA7 expressing different levels of recombinant human 5-HT1A receptors. Colforsin 14-23 5-hydroxytryptamine receptor 1A Homo sapiens 163-169 9179864-4 1997 The proDYN mRNA level began to increase 1 h, then reached and remained at a peak 3-6 h after stimulation by forskolin or PMA. Colforsin 108-117 prodynorphin Rattus norvegicus 4-10 9179864-5 1997 proDYN mRNA levels in forskolin treated cells decreased slightly from their peak after 9 h of treatment, whereas the level of proDYN mRNA returned to the basal level in PMA-treated cells. Colforsin 22-31 prodynorphin Rattus norvegicus 0-6 9179864-9 1997 Calcium influx through both L- and N-type calcium channels and Ca2+/calmodulin-dependent protein kinase II appear to be involved in the increase of proDYN mRNA levels induced by either forskolin or PMA. Colforsin 185-194 prodynorphin Rattus norvegicus 148-154 9065441-3 1997 Compounds (forskolin, 8-bromo-cAMP, and (Sp)-cAMP) that increase cAMP and activate protein kinase A (PKA) were found to inhibit LPS- and cytokine-mediated production of NO as well as the expression of iNOS, whereas compounds (H-89 and (Rp)-cAMP) that decrease cAMP and PKA activity stimulated the production of NO and the expression of iNOS in rat primary astrocytes. Colforsin 11-20 nitric oxide synthase 2 Rattus norvegicus 201-205 9098900-3 1997 Recombinant C1 and C2 domains catalyze the synthesis of cyclic AMP when they are mixed and activated by forskolin, and C2 domains alone also manifest reduced levels of forskolin-stimulated enzyme activity. Colforsin 104-113 complement C2 Homo sapiens 12-21 9098900-3 1997 Recombinant C1 and C2 domains catalyze the synthesis of cyclic AMP when they are mixed and activated by forskolin, and C2 domains alone also manifest reduced levels of forskolin-stimulated enzyme activity. Colforsin 168-177 complement C2 Homo sapiens 12-21 9065441-3 1997 Compounds (forskolin, 8-bromo-cAMP, and (Sp)-cAMP) that increase cAMP and activate protein kinase A (PKA) were found to inhibit LPS- and cytokine-mediated production of NO as well as the expression of iNOS, whereas compounds (H-89 and (Rp)-cAMP) that decrease cAMP and PKA activity stimulated the production of NO and the expression of iNOS in rat primary astrocytes. Colforsin 11-20 nitric oxide synthase 2 Rattus norvegicus 336-340 9065441-4 1997 Forskolin, but not the inactive analogue 1,9-dideoxyforskolin, inhibited NO production and iNOS expression in a dose-dependent manner in astrocytes. Colforsin 0-9 nitric oxide synthase 2 Rattus norvegicus 91-95 9130164-11 1997 The difference between the current elicited by forskolin in wild-type and CF tracheas was highly significantly different (P < 0.001), giving a CFTR-dependent current of 11.2 microA cm-2. Colforsin 47-56 cystic fibrosis transmembrane conductance regulator Mus musculus 146-150 9065441-5 1997 The inhibition of LPS- and/or cytokine-induced NO production in rat C6 glial cells by forskolin suggest that similar to astrocytes, iNOS expression in C6 cells is also regulated by similar mechanisms. Colforsin 86-95 nitric oxide synthase 2 Rattus norvegicus 132-136 9069282-1 1997 Mammalian adenylyl cyclases contain two conserved regions, C1 and C2, which are responsible for forskolin- and G-protein-stimulated catalysis. Colforsin 96-105 heterogeneous nuclear ribonucleoprotein C Homo sapiens 59-68 9054858-6 1997 Similar synergistic activation of MAP kinases was observed when other protein kinase A-activating agents such as forskolin, dibutyryl cAMP, and isobutyl-methylxanthine were used with a protein kinase C-activating agent at the same time. Colforsin 113-122 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 70-86 9138702-2 1997 In RAW 264.7 murine macrophages and rat aortic smooth muscle (RASM) cells lipopolysaccharide (LPS) alone or in combination with interferon gamma (IFN gamma) or forskolin, respectively, stimulated the expression of the 130 kDa inducible isoform of nitric oxide synthase (iNOS) in both a time- and concentration-dependent manner. Colforsin 160-169 nitric oxide synthase 2 Rattus norvegicus 270-274 9074644-5 1997 Expression of the xlAC in COS-7 cells resulted in increased basal AC activity, that was stimulated by forskolin, Gpp(NH)p and aluminium fluoride, and was insensitive to calcium and calcium-calmodulin (Ca2(+)-CaM). Colforsin 102-111 adenylate cyclase 9 L homeolog Xenopus laevis 18-22 9074644-5 1997 Expression of the xlAC in COS-7 cells resulted in increased basal AC activity, that was stimulated by forskolin, Gpp(NH)p and aluminium fluoride, and was insensitive to calcium and calcium-calmodulin (Ca2(+)-CaM). Colforsin 102-111 adenylate cyclase 9 L homeolog Xenopus laevis 20-22 9134219-13 1997 Moreover, staurosporine significantly augmented the activation of C/EBP by IL-1 beta and forskolin. Colforsin 89-98 CCAAT/enhancer binding protein gamma Rattus norvegicus 66-71 9138702-11 1997 In RASM cells chronic PMA pretreatment resulted in down-regulation of alpha and epsilon PKC isoforms and corresponded to potentiation of iNOS expression in response to LPS alone or in combination with forskolin. Colforsin 201-210 nitric oxide synthase 2 Rattus norvegicus 137-141 9138702-13 1997 Co-incubation of RASM cells in the presence of PMA, angiotensin II (AII) or foetal calf serum (FCS) resulted in the inhibition of iNOS expression in response to LPS alone or in combination with forskolin. Colforsin 194-203 angiotensinogen Rattus norvegicus 52-66 9138702-13 1997 Co-incubation of RASM cells in the presence of PMA, angiotensin II (AII) or foetal calf serum (FCS) resulted in the inhibition of iNOS expression in response to LPS alone or in combination with forskolin. Colforsin 194-203 angiotensinogen Rattus norvegicus 68-71 9138702-13 1997 Co-incubation of RASM cells in the presence of PMA, angiotensin II (AII) or foetal calf serum (FCS) resulted in the inhibition of iNOS expression in response to LPS alone or in combination with forskolin. Colforsin 194-203 nitric oxide synthase 2 Rattus norvegicus 130-134 9048609-14 1997 Forskolin (10 microM) significantly reduced GHRH-R mRNA concentrations (37 +/- 6% of control values) indicating that GHRH acts through the cAMP-second messenger system cascade to regulate GHRH-R mRNA. Colforsin 0-9 growth hormone releasing hormone receptor Rattus norvegicus 44-50 9183441-9 1997 In DCTb cells which exhibited swelling-activated Cl- currents subsequently inhibited by DIDS, forskolin could activate CFTR related Cl- currents. Colforsin 94-103 cystic fibrosis transmembrane conductance regulator Oryctolagus cuniculus 119-123 9048595-4 1997 Furthermore, forskolin was shown to reverse the inhibitory effect of H-89 and to prevent the somatostatin-induced reduction in HDC affinity for L-histidine. Colforsin 13-22 somatostatin Oryctolagus cuniculus 93-105 9048595-4 1997 Furthermore, forskolin was shown to reverse the inhibitory effect of H-89 and to prevent the somatostatin-induced reduction in HDC affinity for L-histidine. Colforsin 13-22 histidine decarboxylase Oryctolagus cuniculus 127-130 9048609-14 1997 Forskolin (10 microM) significantly reduced GHRH-R mRNA concentrations (37 +/- 6% of control values) indicating that GHRH acts through the cAMP-second messenger system cascade to regulate GHRH-R mRNA. Colforsin 0-9 growth hormone releasing hormone receptor Rattus norvegicus 188-194 9101540-3 1997 [3H]Forskolin binding significantly decreased in the striatum, hippocampal CA3 sector, dentate gyrus, hilus, thalamus, substantia nigra and cerebellum of 24-month-old (aged) rats, as compared with 6-month-old (adult) animals. Colforsin 4-13 carbonic anhydrase 3 Rattus norvegicus 75-78 9133612-6 1997 ET-1 suppressed forskolin-stimulated accumulation of cAMP through the activation of ET(A) and ET(B) in GH(AB) cells; 1 microM BQ-123 or BQ-788 inhibited the suppression by only 20%, whereas a mixture of BQ-123 and BQ-788 (1 microM each) completely inhibited the cAMP decrease. Colforsin 16-25 endothelin receptor type A Homo sapiens 84-89 9133612-6 1997 ET-1 suppressed forskolin-stimulated accumulation of cAMP through the activation of ET(A) and ET(B) in GH(AB) cells; 1 microM BQ-123 or BQ-788 inhibited the suppression by only 20%, whereas a mixture of BQ-123 and BQ-788 (1 microM each) completely inhibited the cAMP decrease. Colforsin 16-25 endothelin receptor type B Homo sapiens 94-99 9834339-7 1997 Agents that activate PKA at different stages of the PKA activation pathway, including 3-isobutyl-1-methylxanthine (IBMX), forskolin, and cholera toxin, inhibited EGF-induced migration. Colforsin 122-131 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 21-24 9834339-7 1997 Agents that activate PKA at different stages of the PKA activation pathway, including 3-isobutyl-1-methylxanthine (IBMX), forskolin, and cholera toxin, inhibited EGF-induced migration. Colforsin 122-131 epidermal growth factor like 1 Rattus norvegicus 162-165 9072551-6 1997 Neurokinin B and to a lesser extent neurokinin A inhibit forskolin-activated adenylyl cyclase activity. Colforsin 57-66 tachykinin-3 Cavia porcellus 0-12 9068120-8 1997 Application of the D1 agonist SKF 38393, or direct stimulation of adenylyl cyclase with forskolin, also resulted in the phosphorylation of CREB and the induction of c-fos in striatal neurons. Colforsin 88-97 cAMP responsive element binding protein 1 Homo sapiens 139-143 9129186-2 1997 In the present study, we demonstrate that the efficacy of the selective 5-HT(1B) receptor agonist CP 93 129 in inhibiting the forskolin-stimulated adenylyl cyclase activity in the rat substantia nigra was reduced 15 min after intracerebral injection of LSAL compared to vehicle or ALLS (scrambled peptide) injected rats. Colforsin 126-135 5-hydroxytryptamine receptor 1B Rattus norvegicus 72-79 10684111-20 1997 However, forskolin, a cAMP inducer for protein kinase A (PKA) activation, inhibited the phosphorylation of LPS- and PMA-stimulated Raf-1, MAPK p44 and MAPK p42 (Fig. Colforsin 9-18 v-raf-leukemia viral oncogene 1 Mus musculus 131-136 10684111-20 1997 However, forskolin, a cAMP inducer for protein kinase A (PKA) activation, inhibited the phosphorylation of LPS- and PMA-stimulated Raf-1, MAPK p44 and MAPK p42 (Fig. Colforsin 9-18 mitogen-activated protein kinase 3 Mus musculus 143-146 9068120-8 1997 Application of the D1 agonist SKF 38393, or direct stimulation of adenylyl cyclase with forskolin, also resulted in the phosphorylation of CREB and the induction of c-fos in striatal neurons. Colforsin 88-97 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 165-170 10684111-20 1997 However, forskolin, a cAMP inducer for protein kinase A (PKA) activation, inhibited the phosphorylation of LPS- and PMA-stimulated Raf-1, MAPK p44 and MAPK p42 (Fig. Colforsin 9-18 cyclin-dependent kinase 20 Mus musculus 156-159 9083791-6 1997 A few opiates, namely lofentanil, a 4-anilinopiperidine derivative and etorphine, a 6,14-endo-ethenotetrahydrothebaine derivative, were found to be quite potent not only in competing with binding of [3H]nociceptin at the ORL 1 receptor but also in inhibiting forskolin-induced accumulation of cyclic AMP in intact recombinant CHO cells. Colforsin 259-268 prepronociceptin Cricetulus griseus 203-213 10684111-22 1997 Similarly, in agreement with a very recent report from David, M et al in NIH, in which they indicated that forskolin (30 mumol/L) inhibited IFN-beta-stimulated ERK activity by U 266 cells (J. Biol. Colforsin 107-116 interferon beta 1 Homo sapiens 140-148 10684111-22 1997 Similarly, in agreement with a very recent report from David, M et al in NIH, in which they indicated that forskolin (30 mumol/L) inhibited IFN-beta-stimulated ERK activity by U 266 cells (J. Biol. Colforsin 107-116 mitogen-activated protein kinase 1 Homo sapiens 160-163 10684111-24 1997 271: 4585-4588 1996), we found that the levels of phosphorylations of Raf-1 and ERK1 and ERK2 were declined when forskolin (30 mumol/L) was added to macrophages for 20 min at 37 degrees C prior to the stimulation by LPS and PMA. Colforsin 113-122 v-raf-leukemia viral oncogene 1 Mus musculus 70-75 10684111-24 1997 271: 4585-4588 1996), we found that the levels of phosphorylations of Raf-1 and ERK1 and ERK2 were declined when forskolin (30 mumol/L) was added to macrophages for 20 min at 37 degrees C prior to the stimulation by LPS and PMA. Colforsin 113-122 mitogen-activated protein kinase 3 Mus musculus 80-84 10684111-24 1997 271: 4585-4588 1996), we found that the levels of phosphorylations of Raf-1 and ERK1 and ERK2 were declined when forskolin (30 mumol/L) was added to macrophages for 20 min at 37 degrees C prior to the stimulation by LPS and PMA. Colforsin 113-122 mitogen-activated protein kinase 1 Mus musculus 89-93 10684111-25 1997 Interestingly, under the same condition, forskolin (30 mumol/L) stimulated the phosphorylation of LPS- and PMA-triggered p38 MAPK of murine peritoneal suppressor macrophages, suggesting that activatio Colforsin 41-50 mitogen-activated protein kinase 14 Mus musculus 121-129 9070641-0 1997 D2 dopamine receptor activation inhibits basal and forskolin-evoked acetylcholine release from dissociated striatal cholinergic interneurons. Colforsin 51-60 dopamine receptor D2 Homo sapiens 0-20 9138726-6 1997 Further support was provided by the observation of a marked accentuation and attenuation in a dose-related manner of ethanol-induced motor impairment as well as CHA"s accentuation of ethanol"s motor impairment by intracerebellar miconazole and forskolin, respectively. Colforsin 244-253 POC1 centriolar protein A Mus musculus 161-164 9085272-4 1997 In the present experiment, the activators of protein kinase C and the adenylate cyclase, PMA (5 nM) and forskolin (10 microM) respectively, have elevated the steady state levels of LH beta mRNA significantly by 18 h at the specific concentrations shown in the parenthesis. Colforsin 104-113 luteinizing hormone subunit beta Rattus norvegicus 181-188 9085272-5 1997 Subsequently, we have determined whether the elevation of LH beta mRNA levels by either PMA or forskolin is due to the new synthesis of LH beta mRNA or the suppression of LH beta mRNA turnover. Colforsin 95-104 luteinizing hormone subunit beta Rattus norvegicus 58-65 9085272-5 1997 Subsequently, we have determined whether the elevation of LH beta mRNA levels by either PMA or forskolin is due to the new synthesis of LH beta mRNA or the suppression of LH beta mRNA turnover. Colforsin 95-104 luteinizing hormone subunit beta Rattus norvegicus 136-143 9085272-5 1997 Subsequently, we have determined whether the elevation of LH beta mRNA levels by either PMA or forskolin is due to the new synthesis of LH beta mRNA or the suppression of LH beta mRNA turnover. Colforsin 95-104 luteinizing hormone subunit beta Rattus norvegicus 136-143 9085272-6 1997 Result showed that the ability of PMA or forskolin to elevate the LH beta mRNA levels was suppressed by the addition of actinomycin D, an inhibitor of transcription. Colforsin 41-50 luteinizing hormone subunit beta Rattus norvegicus 66-73 9055828-7 1997 The transcriptional activities of all SCF deletion constructs treated with cyclic adenosine 3",5"-monophosphate (cAMP) and forskolin were increased two- to threefold, indicating that SCF transcription in Sertoli cells is regulated by a cAMP-dependent pathway in the proximal promoter region. Colforsin 123-132 KIT ligand Rattus norvegicus 38-41 9038367-2 1997 [3H]Nociceptin/orphanin FQ (OFQ) bound to the cell membrane specifically (Kd = 3.6 +/- 0.6 nM) and inhibited forskolin-stimulated cAMP accumulation (EC50 = 0.72 +/- 0.3 nM). Colforsin 109-118 prepronociceptin Mus musculus 15-26 9055828-7 1997 The transcriptional activities of all SCF deletion constructs treated with cyclic adenosine 3",5"-monophosphate (cAMP) and forskolin were increased two- to threefold, indicating that SCF transcription in Sertoli cells is regulated by a cAMP-dependent pathway in the proximal promoter region. Colforsin 123-132 KIT ligand Rattus norvegicus 183-186 9032464-9 1997 An increase in LPL mRNA level similar to (but not significantly exceeding) that caused by noradrenaline could also be induced by the cAMP-elevating agents forskolin and cholera toxin, and 8-Br-cAMP also increased LPL mRNA levels. Colforsin 155-164 lipoprotein lipase Rattus norvegicus 15-18 9065735-5 1997 The adenylate cyclase stimulator forskolin (1 microM) did not affect the basal secretion but strongly potentiated the release evoked by all secretagogues used, suggesting a role for protein kinase A (PKA) downstream of the receptor. Colforsin 33-42 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 182-198 9065735-5 1997 The adenylate cyclase stimulator forskolin (1 microM) did not affect the basal secretion but strongly potentiated the release evoked by all secretagogues used, suggesting a role for protein kinase A (PKA) downstream of the receptor. Colforsin 33-42 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 200-203 9124353-7 1997 Also, forskolin/8-(4-chlorophenylthio)-cAMP stimulated 36Cl- efflux rates only in medium and large cholangiocytes, consistent with selective functional expression of CFTR in these subpopulations. Colforsin 6-15 CF transmembrane conductance regulator Rattus norvegicus 166-170 9089652-7 1997 The PKA inhibitor H-89 attenuated the ET-1 response to PGE2, forskolin and ChT, but not that due to the PKC agonist TPA. Colforsin 61-70 endothelin 1 Homo sapiens 38-42 9071561-0 1997 Downregulation of TGF-beta 1 gene expression in anterior pituitary cells treated with forskolin. Colforsin 86-95 transforming growth factor beta 1 Homo sapiens 18-28 9113415-0 1997 Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells. Colforsin 10-19 kininogen 1 Canis lupus familiaris 23-33 9113415-2 1997 Pretreatment of TSMCs with either forskolin or dibutyryl cyclic AMP attenuated BK-stimulated responses. Colforsin 34-43 kininogen 1 Canis lupus familiaris 79-81 9113415-6 1997 The KD and Bmax, values of the BK receptor for [3H]BK binding were not significantly changed by forskolin treatment for 30 min and 4 h. The AlF4(-)-induced IPs accumulation was attenuated by forskolin, indicating that G protein(s) are directly activated by AlF4- and uncoupled to phospholipase C by forskolin treatment. Colforsin 191-200 kininogen 1 Canis lupus familiaris 31-33 9113415-6 1997 The KD and Bmax, values of the BK receptor for [3H]BK binding were not significantly changed by forskolin treatment for 30 min and 4 h. The AlF4(-)-induced IPs accumulation was attenuated by forskolin, indicating that G protein(s) are directly activated by AlF4- and uncoupled to phospholipase C by forskolin treatment. Colforsin 191-200 kininogen 1 Canis lupus familiaris 31-33 9071561-3 1997 Treatment with a dose of forskolin (5 microM), known to induce PRL gene transcription, significantly inhibited TGF-beta 1 levels in culture medium and TGF-beta 1 mRNA levels in cellular extracts. Colforsin 25-34 prolactin Homo sapiens 63-66 9071561-3 1997 Treatment with a dose of forskolin (5 microM), known to induce PRL gene transcription, significantly inhibited TGF-beta 1 levels in culture medium and TGF-beta 1 mRNA levels in cellular extracts. Colforsin 25-34 transforming growth factor beta 1 Homo sapiens 111-121 9071561-3 1997 Treatment with a dose of forskolin (5 microM), known to induce PRL gene transcription, significantly inhibited TGF-beta 1 levels in culture medium and TGF-beta 1 mRNA levels in cellular extracts. Colforsin 25-34 transforming growth factor beta 1 Homo sapiens 151-161 9071561-4 1997 Nuclear run-off transcription analysis revealed that the forskolin effect on TGF-beta 1 mRNA expression is due to reduced transcription initiation rates. Colforsin 57-66 transforming growth factor beta 1 Homo sapiens 77-87 9157011-5 1997 Since VILIP inhibits the forskolin-induced formation of cAMP, it is conceivable that VILIP may directly affect the olfactory adenylyl cyclase. Colforsin 25-34 visinin-like 1 Rattus norvegicus 6-11 9002992-6 1997 Both TTF-1 mRNA and protein were significantly decreased after the addition of (Bu)2 cAMP or forskolin for 24 h, whereas they were not decreased by 12-O-tetradecanoyl-phorbol-13-acetate. Colforsin 93-102 transcription termination factor 1 Rattus norvegicus 5-10 9003002-4 1997 Reverse transcriptase-PCR demonstrates that the addition of NE; selective beta 1-, beta 2-, or beta 3-adrenergic receptor agonists; or agents increasing cAMP production, such as forskolin, to brown adipocytes stimulates inducible NOS (iNOS) messenger RNA, which is present within 4 h after exposure. Colforsin 178-187 nitric oxide synthase 2 Rattus norvegicus 220-233 9003002-4 1997 Reverse transcriptase-PCR demonstrates that the addition of NE; selective beta 1-, beta 2-, or beta 3-adrenergic receptor agonists; or agents increasing cAMP production, such as forskolin, to brown adipocytes stimulates inducible NOS (iNOS) messenger RNA, which is present within 4 h after exposure. Colforsin 178-187 nitric oxide synthase 2 Rattus norvegicus 235-239 9157011-5 1997 Since VILIP inhibits the forskolin-induced formation of cAMP, it is conceivable that VILIP may directly affect the olfactory adenylyl cyclase. Colforsin 25-34 visinin-like 1 Rattus norvegicus 85-90 9034831-5 1997 First, iNOS expression was also inhibited by agents such as isoproterenol and forskolin, which cause an elevation of cAMP levels, and by dibutyryl cAMP (dbcAMP), a cAMP stable analogue. Colforsin 78-87 nitric oxide synthase 2 Rattus norvegicus 7-11 9021933-5 1997 The addition of forskolin, which activates CFTR anion channel activity through the cAMP system, resulted in net fluid secretion in normal gallbladders. Colforsin 16-25 cystic fibrosis transmembrane conductance regulator Mus musculus 43-47 9040011-8 1997 Forskolin treatment reverses Raf-1 hyperphosphorylation in the cells and inhibits proliferation by blocking G1/S transition. Colforsin 0-9 v-raf-leukemia viral oncogene 1 Mus musculus 29-34 9013764-17 1997 Moreover, agents stimulating LH/CG receptor-associated intracellular signaling pathways (forskolin and a phorbol ester) readily mimicked the effect of hCG in down-regulating ER beta mRNA in cultured granulosa cells. Colforsin 89-98 glycoprotein hormones, alpha polypeptide Homo sapiens 32-34 9041048-8 1997 The effect of PTH could be mimicked by the cAMP analogs Bt2 cAMP and forskolin, but not by PTH fragment 3-34, calcium ionophore A23187, or by the PKC activator phorbol 12-myristate 13-acetate. Colforsin 69-78 parathyroid hormone Rattus norvegicus 14-17 9055190-2 1997 All had nanomolar affinities for 5-HT1A receptors and fully inhibited forskolin-stimulated adenylyl cyclase in-vitro (i.e. the four compounds appeared to be 5-HT1A agonists). Colforsin 70-79 5-hydroxytryptamine receptor 1A Rattus norvegicus 157-163 9013764-17 1997 Moreover, agents stimulating LH/CG receptor-associated intracellular signaling pathways (forskolin and a phorbol ester) readily mimicked the effect of hCG in down-regulating ER beta mRNA in cultured granulosa cells. Colforsin 89-98 glycoprotein hormones, alpha polypeptide Homo sapiens 151-154 9013764-17 1997 Moreover, agents stimulating LH/CG receptor-associated intracellular signaling pathways (forskolin and a phorbol ester) readily mimicked the effect of hCG in down-regulating ER beta mRNA in cultured granulosa cells. Colforsin 89-98 estrogen receptor 2 Rattus norvegicus 174-181 9006930-2 1997 We found that forskolin, an adenylyl cyclase activator, markedly enhanced GnT-III at the transcriptional level in various hepatoma cells and hepatocytes, resulting in an increase of bisecting GlcNAc residues in various glycoproteins, as judged from the lectin binding to erythroagglutinating phytohemagglutinin (E-PHA). Colforsin 14-23 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Rattus norvegicus 74-81 9006930-8 1997 The expression levels of lysosomal membrane glycoprotein 1 and gamma-glutamyltranspeptidase on the cell surface were decreased at 12 h after forskolin treatment, indicating that the bisecting GlcNAc structure may act as a negative sorting signal for the cell surface glycoproteins and may alter the characteristics of hepatoma cells. Colforsin 141-150 lysosomal-associated membrane protein 1 Rattus norvegicus 25-58 9006930-3 1997 In whole cell lysates, the E-PHA binding was increased, and leukoagglutinating phytohemagglutinin (L-PHA) binding was decreased at 12 h after forskolin treatment, by time, both GnT-III activity and mRNA had reached the maximum levels. Colforsin 142-151 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Rattus norvegicus 177-184 9006930-8 1997 The expression levels of lysosomal membrane glycoprotein 1 and gamma-glutamyltranspeptidase on the cell surface were decreased at 12 h after forskolin treatment, indicating that the bisecting GlcNAc structure may act as a negative sorting signal for the cell surface glycoproteins and may alter the characteristics of hepatoma cells. Colforsin 141-150 gamma-glutamyltransferase 1 Rattus norvegicus 63-91 8999953-4 1997 Forskolin treatment alone only caused a 2-3-fold activation of the HREN promoter in Calu-6 cells, but nearly a 10-fold activation in JEG-3 cells, which do not express renin but are highly responsive to cAMP. Colforsin 0-9 renin Homo sapiens 167-172 9037509-5 1997 Forskolin, but not its inactive analog 1,9-dideoxyforskolin, mimicked the stimulatory effect of VIP on spontaneous IPSCs and mIPSCs. Colforsin 0-9 vasoactive intestinal peptide Homo sapiens 96-99 9013884-7 1997 HEK293 cells transiently transfected with the chimeric rEP3hEP4R cDNA expressed a plasma membrane PGE2 binding site with a slightly lower Kd value for PGE2 but an identical binding profile for receptor-specific ligands as cells transfected with the native rat EP(3beta)R. In HepG2 cells stably transfected with the chimeric rEP3hEP4R cDNA PGE2 did not increase cAMP formation characteristic of Gs coupling but attenuated the forskolin-stimulated cAMP synthesis characteristic of Gi coupling. Colforsin 425-434 prostaglandin E receptor 3 Rattus norvegicus 55-64 9020856-6 1997 Treatment of C2C12 cells with forskolin, which is known to induce TIS1 expression, also stimulated MCK reporter gene activity. Colforsin 30-39 nuclear receptor subfamily 4, group A, member 1 Mus musculus 66-70 9020856-6 1997 Treatment of C2C12 cells with forskolin, which is known to induce TIS1 expression, also stimulated MCK reporter gene activity. Colforsin 30-39 creatine kinase, muscle Mus musculus 99-102 9016803-5 1997 In brain homogenates, both OFQ/N and OFQ/N(1-11) inhibit forskolin-stimulated camp accumulation with IC50 values of 1 nM or less, an action which is readily reversed by opioid antagonists. Colforsin 57-66 prepronociceptin Mus musculus 27-32 9020878-4 1997 The effects of 100 nM NPY were mimicked by H-89, while forskolin and 8-Br-cAMP mimicked the effects of 1 microM NPY. Colforsin 55-64 neuropeptide Y Homo sapiens 112-115 9020878-5 1997 Both basal and forskolin-stimulated cAMP levels were inhibited by 100 nM NPY and by 100 nM NPY(13-36), a selective agonist of the NPY Y2-receptor subtype. Colforsin 15-24 neuropeptide Y Homo sapiens 73-76 9020878-5 1997 Both basal and forskolin-stimulated cAMP levels were inhibited by 100 nM NPY and by 100 nM NPY(13-36), a selective agonist of the NPY Y2-receptor subtype. Colforsin 15-24 neuropeptide Y Homo sapiens 91-94 9020878-5 1997 Both basal and forskolin-stimulated cAMP levels were inhibited by 100 nM NPY and by 100 nM NPY(13-36), a selective agonist of the NPY Y2-receptor subtype. Colforsin 15-24 neuropeptide Y receptor Y2 Homo sapiens 130-145 9121677-2 1997 The aim of this study was to examine effects of NPY and its related peptides on forskolin (1 microM)-stimulated cyclic AMP production in slices of the rat NTS. Colforsin 80-89 neuropeptide Y Rattus norvegicus 48-51 9016773-3 1997 Forskolin-mediated elevation of intracellular cAMP levels led to a qualitatively similar inhibitory effect on both ANP gene expression and secretion. Colforsin 0-9 natriuretic peptide A Homo sapiens 115-118 9016803-5 1997 In brain homogenates, both OFQ/N and OFQ/N(1-11) inhibit forskolin-stimulated camp accumulation with IC50 values of 1 nM or less, an action which is readily reversed by opioid antagonists. Colforsin 57-66 prepronociceptin Mus musculus 37-42 9009224-3 1997 In addition, all three MCPs showed dose-dependent inhibition of adenylyl cyclase activity stimulated by forskolin (IC50 values: 0.3 nM for MCP-1, 7 nM for MCP-2, and 1.5 nM for MCP-3). Colforsin 104-113 C-C motif chemokine ligand 2 Homo sapiens 139-144 8990204-5 1997 In contrast, elevating cAMP by forskolin treatment markedly increases AA-NAT activity without producing strong changes in AA-NAT mRNA levels, and lowering cAMP by norepinephrine treatment decreases enzyme activity without markedly decreasing mRNA. Colforsin 31-40 aralkylamine N-acetyltransferase Gallus gallus 70-76 9001390-8 1997 Application of 8-CPT cAMP, forskolin/isobutylmethylxanthine or isoproterenol blocked Erk activation following hypo-osmotic treatment of the cells, suggesting a role of the Ras/Raf pathway upstream from Erk-1 and Erk-2. Colforsin 27-36 Eph receptor B1 Rattus norvegicus 85-88 9001390-8 1997 Application of 8-CPT cAMP, forskolin/isobutylmethylxanthine or isoproterenol blocked Erk activation following hypo-osmotic treatment of the cells, suggesting a role of the Ras/Raf pathway upstream from Erk-1 and Erk-2. Colforsin 27-36 mitogen activated protein kinase 3 Rattus norvegicus 202-207 9001390-8 1997 Application of 8-CPT cAMP, forskolin/isobutylmethylxanthine or isoproterenol blocked Erk activation following hypo-osmotic treatment of the cells, suggesting a role of the Ras/Raf pathway upstream from Erk-1 and Erk-2. Colforsin 27-36 mitogen activated protein kinase 1 Rattus norvegicus 212-217 9009224-3 1997 In addition, all three MCPs showed dose-dependent inhibition of adenylyl cyclase activity stimulated by forskolin (IC50 values: 0.3 nM for MCP-1, 7 nM for MCP-2, and 1.5 nM for MCP-3). Colforsin 104-113 C-C motif chemokine ligand 8 Homo sapiens 155-160 9009224-3 1997 In addition, all three MCPs showed dose-dependent inhibition of adenylyl cyclase activity stimulated by forskolin (IC50 values: 0.3 nM for MCP-1, 7 nM for MCP-2, and 1.5 nM for MCP-3). Colforsin 104-113 C-C motif chemokine ligand 7 Homo sapiens 177-182 8977429-3 1997 Our data indicate that the human Mel1a receptor is coupled to inhibition of forskolin-stimulated cAMP accumulation by a pertussis toxin-sensitive G protein. Colforsin 76-85 melatonin receptor 1A Homo sapiens 33-47 9530435-7 1997 Sulprostone (EP3 > EP1) did not stimulate adenylyl cyclase activity per se, but inhibited forskolin-stimulated adenylyl cyclase in a pertussis toxin (PT) sensitive way. Colforsin 93-102 prostaglandin E receptor 3 Homo sapiens 13-16 9530435-7 1997 Sulprostone (EP3 > EP1) did not stimulate adenylyl cyclase activity per se, but inhibited forskolin-stimulated adenylyl cyclase in a pertussis toxin (PT) sensitive way. Colforsin 93-102 prostaglandin E receptor 1 Homo sapiens 22-25 9003416-0 1997 Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant. Colforsin 71-80 phosphodiesterase 4D Homo sapiens 181-186 9003416-0 1997 Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant. Colforsin 71-80 phosphodiesterase 4A Homo sapiens 250-255 9003416-6 1997 Forskolin treatment did not induce transcripts for either PDE4B or PDE4C; however, it reduced the RT-PCR signal for PDE4A transcripts and markedly enhanced that for PDE4D transcripts. Colforsin 0-9 phosphodiesterase 4A Homo sapiens 116-121 9003416-6 1997 Forskolin treatment did not induce transcripts for either PDE4B or PDE4C; however, it reduced the RT-PCR signal for PDE4A transcripts and markedly enhanced that for PDE4D transcripts. Colforsin 0-9 phosphodiesterase 4D Homo sapiens 165-170 9003416-7 1997 Using RT-PCR primers for PDE4 splice variants, a weak signal for PDE4D1 was evident in control cells whereas, in forskolin-treated cells, clear signals for both PDE4D1 and PDE4D2 were detected. Colforsin 113-122 phosphodiesterase 4A Homo sapiens 25-29 9003416-10 1997 Forskolin treatment led to a marked decrease of this novel PDE4A species and allowed the detection of a strong signal for an approximately 67 kDa PDE4D species, suggested to be PDE4D1, but did not induce PDE4B and PDE4C isoforms. Colforsin 0-9 phosphodiesterase 4A Homo sapiens 59-64 9003416-10 1997 Forskolin treatment led to a marked decrease of this novel PDE4A species and allowed the detection of a strong signal for an approximately 67 kDa PDE4D species, suggested to be PDE4D1, but did not induce PDE4B and PDE4C isoforms. Colforsin 0-9 phosphodiesterase 4D Homo sapiens 146-151 9193641-2 1997 Persistent treatment (24-48 h) of C6 glioma cells with cholera toxin (100 ng/ml) caused marked downregulation of Gs alpha (75-80%) which could not be mimicked by dibutyryl cAMP (1 mM) and forskolin (10 microM) over the same time periods suggesting that CT-mediated Gs alpha downregulation is independent of cAMP production. Colforsin 188-197 GNAS complex locus Homo sapiens 113-121 9097034-3 1997 Both Cx32 and P0 mRNAs were detectable in cultured Schwann cells and were enhanced by the addition of forskolin. Colforsin 102-111 gap junction protein, beta 1 Rattus norvegicus 5-9 8977379-8 1997 Treatment of cells with forskolin (FSK; 50 microM), which activates the cAMP-protein kinase A pathway, resulted in an 8- to 10-fold up-regulation of VDR by 6 h, and VDR remained elevated at 24 h, as we have reported for other cells. Colforsin 24-33 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 149-152 8977379-8 1997 Treatment of cells with forskolin (FSK; 50 microM), which activates the cAMP-protein kinase A pathway, resulted in an 8- to 10-fold up-regulation of VDR by 6 h, and VDR remained elevated at 24 h, as we have reported for other cells. Colforsin 24-33 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 165-168 8977379-8 1997 Treatment of cells with forskolin (FSK; 50 microM), which activates the cAMP-protein kinase A pathway, resulted in an 8- to 10-fold up-regulation of VDR by 6 h, and VDR remained elevated at 24 h, as we have reported for other cells. Colforsin 35-38 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 149-152 8977379-8 1997 Treatment of cells with forskolin (FSK; 50 microM), which activates the cAMP-protein kinase A pathway, resulted in an 8- to 10-fold up-regulation of VDR by 6 h, and VDR remained elevated at 24 h, as we have reported for other cells. Colforsin 35-38 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 165-168 8977379-11 1997 VDR up-regulation by FSK pretreatment augmented the NGF response to 1,25-(OH)2D3 2-fold compared to that in vehicle-pretreated cells for a total 6-fold increase compared to basal NGF levels. Colforsin 21-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 8977379-13 1997 The effects of these analogs were further enhanced by prior up-regulation of VDR with FSK. Colforsin 86-89 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 77-80 9007683-5 1997 The inhibitory action of ET-1 was still observed when ICaL was previously increased by forskolin (3 x 10(-6) M), 8-bromo-cyclic adenosine monophosphate (8-Br-cAMP; 200 microM), or cAMP (100 microM) in presence of isobutyl methyl xanthine (IBMX; 10(-6) M), suggesting that the antiadrenergic action of ET-1 on ICaL was exerted independent of the cAMP-dependent phosphorylation pathway. Colforsin 87-96 endothelin 1 Rattus norvegicus 25-29 9039126-5 1997 These actions are mimicked by forskolin 1 to 10 mumol/L, a direct activator of adenylate cyclase and 8-bromo-cAMP 0.1 to 1 mmol/L, and are blocked by a specific protein kinase A (PKA) inhibitor N-[2-(P-bromcoinnamylamino)ethyl]-5-isoquinoline-sulfonamide (H89) but not blocked by its negative control. Colforsin 30-39 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 161-177 9039126-5 1997 These actions are mimicked by forskolin 1 to 10 mumol/L, a direct activator of adenylate cyclase and 8-bromo-cAMP 0.1 to 1 mmol/L, and are blocked by a specific protein kinase A (PKA) inhibitor N-[2-(P-bromcoinnamylamino)ethyl]-5-isoquinoline-sulfonamide (H89) but not blocked by its negative control. Colforsin 30-39 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 179-182 9018005-7 1997 The adenylate cyclase activator forskolin (10 micromol/l) potentiated the low concentration CCK-8 effect, shifting the peak stimulation to a CCK-8 concentration of 10 pmol/l, and inhibited the high concentration CCK-8 effect on 60-hour cultured cells. Colforsin 32-41 cholecystokinin Homo sapiens 92-95 9018005-7 1997 The adenylate cyclase activator forskolin (10 micromol/l) potentiated the low concentration CCK-8 effect, shifting the peak stimulation to a CCK-8 concentration of 10 pmol/l, and inhibited the high concentration CCK-8 effect on 60-hour cultured cells. Colforsin 32-41 cholecystokinin Homo sapiens 141-144 9018005-7 1997 The adenylate cyclase activator forskolin (10 micromol/l) potentiated the low concentration CCK-8 effect, shifting the peak stimulation to a CCK-8 concentration of 10 pmol/l, and inhibited the high concentration CCK-8 effect on 60-hour cultured cells. Colforsin 32-41 cholecystokinin Homo sapiens 141-144 9366515-8 1997 The LPS-induced TNF-alpha production from macrophages was also inhibited by forskolin 3 microM, an activator of adenylate cyclase. Colforsin 76-85 toll-like receptor 4 Mus musculus 4-7 8978725-2 1997 The loss in Gs alpha was accompanied by reduced (64.3 +/- 0.35% of control values) NaF-mediated stimulation of adenylyl cyclase and was independent of accumulated cyclic AMP (cAMP) levels, because neither forskolin nor dibutyryl cAMP treatment of cells mimicked the DA-induced effects. Colforsin 205-214 GNAS complex locus Homo sapiens 12-20 8978725-5 1997 Gs alpha mRNA levels were also attenuated (52 +/- 3.5% of control values) by the D1-selective agonist SKF R-38393 but not by forskolin or dibutyryl cAMP. Colforsin 125-134 GNAS complex locus Homo sapiens 0-8 8985363-7 1997 Both MAPK activation and IL-8 production were inhibited by forskolin, a potent inhibitor of Raf-1. Colforsin 59-68 mitogen-activated protein kinase 1 Homo sapiens 5-9 8985363-7 1997 Both MAPK activation and IL-8 production were inhibited by forskolin, a potent inhibitor of Raf-1. Colforsin 59-68 C-X-C motif chemokine ligand 8 Homo sapiens 25-29 8985363-7 1997 Both MAPK activation and IL-8 production were inhibited by forskolin, a potent inhibitor of Raf-1. Colforsin 59-68 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 92-97 8978709-2 1997 Levels of alpha 2A-AR mRNA were reduced to approximately 10% of control levels within 4 h of 1 microM FSK treatment. Colforsin 102-105 adrenoceptor alpha 2A Rattus norvegicus 10-21 8978709-4 1997 A 90% decrease in alpha 2A-AR mRNA levels was observed with 50 nM PMA in 4 h. The decrease in alpha 2A-AR mRNA levels caused by FSK and PMA treatment appears to be the result of decreases in transcription of the alpha 2A-AR gene and is not due to decreases in alpha 2A-AR mRNA degradation rate. Colforsin 128-131 adrenoceptor alpha 2A Rattus norvegicus 18-29 8978709-4 1997 A 90% decrease in alpha 2A-AR mRNA levels was observed with 50 nM PMA in 4 h. The decrease in alpha 2A-AR mRNA levels caused by FSK and PMA treatment appears to be the result of decreases in transcription of the alpha 2A-AR gene and is not due to decreases in alpha 2A-AR mRNA degradation rate. Colforsin 128-131 adrenoceptor alpha 2A Rattus norvegicus 94-105 8978709-4 1997 A 90% decrease in alpha 2A-AR mRNA levels was observed with 50 nM PMA in 4 h. The decrease in alpha 2A-AR mRNA levels caused by FSK and PMA treatment appears to be the result of decreases in transcription of the alpha 2A-AR gene and is not due to decreases in alpha 2A-AR mRNA degradation rate. Colforsin 128-131 adrenoceptor alpha 2A Rattus norvegicus 94-105 8978709-4 1997 A 90% decrease in alpha 2A-AR mRNA levels was observed with 50 nM PMA in 4 h. The decrease in alpha 2A-AR mRNA levels caused by FSK and PMA treatment appears to be the result of decreases in transcription of the alpha 2A-AR gene and is not due to decreases in alpha 2A-AR mRNA degradation rate. Colforsin 128-131 adrenoceptor alpha 2A Rattus norvegicus 94-105 9284080-7 1997 Rp-cAMPS antagonized the relaxation elicited by forskolin, papaverine and vinpocetine, but not that of rolipram and 8-BrcAMP. Colforsin 48-57 calmodulin 2, pseudogene 1 Rattus norvegicus 3-8 9416763-2 1997 Forskolin (0.1 to 6 microM) induced concentration-dependent relaxation on KCl-induced tonic contractions in rat uterus (IC50: 0.55 +/- 0.12 microM) which was antagonized (p<0.05) by Rp-cAMPS (30 microM), TPCK (3 microM), cycloheximide (300 microM), actinomycin D (4 and 12 microM) and TPCK (3 microM) plus actinomycin D (12 microM). Colforsin 0-9 calmodulin 2, pseudogene 1 Rattus norvegicus 188-193 9366515-8 1997 The LPS-induced TNF-alpha production from macrophages was also inhibited by forskolin 3 microM, an activator of adenylate cyclase. Colforsin 76-85 tumor necrosis factor Mus musculus 16-25 9416763-7 1997 Our results suggest that, in rat uterus, forskolin: a) produced cAMP-dependent relaxation, as this is antagonized by Rp-cAMP and TPCK, and b) increased the activity of ornithine decarboxylase, as this is inhibited by DFMO. Colforsin 41-50 ornithine decarboxylase 1 Rattus norvegicus 168-191 9395253-3 1997 When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Colforsin 41-50 5-hydroxytryptamine receptor 1F Homo sapiens 122-128 8994186-4 1997 We provide evidence that nurr1 and nur77 are rapidly induced by CRF in primary pituitary cells and that this induction is mimicked by forskolin in an anterior pituitary cell line. Colforsin 134-143 nuclear receptor subfamily 4 group A member 2 Homo sapiens 25-30 8994186-5 1997 Further, we demonstrate that both nurr1- and forskolin-dependent induction of a POMC-chloramphenicol acetyltransferase reporter gene are inhibited by mutation of the nurr1-binding site within the POMC promoter and that this site alone can confer cAMP responsiveness to a heterologous promoter. Colforsin 45-54 proopiomelanocortin Homo sapiens 80-84 8994186-5 1997 Further, we demonstrate that both nurr1- and forskolin-dependent induction of a POMC-chloramphenicol acetyltransferase reporter gene are inhibited by mutation of the nurr1-binding site within the POMC promoter and that this site alone can confer cAMP responsiveness to a heterologous promoter. Colforsin 45-54 nuclear receptor subfamily 4 group A member 2 Homo sapiens 166-171 8994186-5 1997 Further, we demonstrate that both nurr1- and forskolin-dependent induction of a POMC-chloramphenicol acetyltransferase reporter gene are inhibited by mutation of the nurr1-binding site within the POMC promoter and that this site alone can confer cAMP responsiveness to a heterologous promoter. Colforsin 45-54 proopiomelanocortin Homo sapiens 196-200 9031467-5 1997 HEL cells grown for 24 h in the presence of 50 microM forskolin, an adenylate cyclase activator, demonstrate further increase in PDE3A of 274% of control (p = 0.03). Colforsin 54-63 phosphodiesterase 3A Homo sapiens 129-134 8971765-10 1997 The FGFR1 transcript level is increased in the presence of forskolin. Colforsin 59-68 fibroblast growth factor receptor 1 Homo sapiens 4-9 9272575-4 1997 After a sustained incubation with isoproterenol or forskolin, the accumulation of cAMP could still be observed in S49 beta Gs cells, expressing the fusion gene, which showed, in addition, an up-regulation of their beta 2AR binding sites, while in S49 wt cells, the same treatments completely abolished the rise of cAMP and markedly reduced the number of receptors. Colforsin 51-60 adrenergic receptor, beta 2 Mus musculus 214-222 9144638-7 1997 Agonists of mGluR4 caused a minor decrease in forskolin-induced cAMP formation in Sf-9 cells expressing either mGluR4a or mGluR4b, suggesting that both receptors are coupled to adenylate cyclase in an inhibitory manner. Colforsin 46-55 glutamate receptor, ionotropic, AMPA4 (alpha 4) Mus musculus 12-18 8961279-6 1996 These beta 2-adrenergic receptor transformants, nonetheless, remained resistant to forskolin and ACTH. Colforsin 83-92 adrenergic receptor, beta 2 Mus musculus 6-32 8993475-4 1996 Comparisons with forskolin, a known cAMP inducer, suggest that the increase in intracellular cAMP represents at least one of the transduction pathways involved in IL-2 inhibition, especially in the higher range of neuropeptide concentration. Colforsin 17-26 interleukin 2 Mus musculus 163-167 8981923-7 1996 Analysis of early steps associated with growth inhibition indicated that: (a) similar to ET-1, forskolin decreased c-jun mRNA induction without affecting c-fos and krox 24 mRNA expression; (b) ET-1, sarafotoxin-S6C, as well as forskolin, reduced activation of both c-Jun kinase and extracellular signal-regulated kinase. Colforsin 95-104 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 115-120 8981923-7 1996 Analysis of early steps associated with growth inhibition indicated that: (a) similar to ET-1, forskolin decreased c-jun mRNA induction without affecting c-fos and krox 24 mRNA expression; (b) ET-1, sarafotoxin-S6C, as well as forskolin, reduced activation of both c-Jun kinase and extracellular signal-regulated kinase. Colforsin 95-104 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 265-270 8981923-8 1996 Finally, forskolin, PGI2, and PGE2 raised by fivefold the number of ET binding sites after 6 h, and increased the proportion of ETB receptors from 50% in control cells to 80% in treated cells. Colforsin 9-18 endothelin receptor type B Homo sapiens 128-131 8954955-2 1996 Control vector-transfected Caco-2 cell monolayer preparations (Caco-2-H) responded to forskolin with an increase in short circuit current (Isc) mediated by CFTR. Colforsin 86-95 CF transmembrane conductance regulator Homo sapiens 156-160 8997189-2 1996 ICl and Cm increased in parallel when oocytes expressing CFTR were stimulated by forskolin (10 microM) and 3-isobutyl-1-methylxanthine (1 mM). Colforsin 81-90 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 57-61 8940364-9 1996 When mouse Sertoli SF7 or human JEG.3 cell lines were transfected with these plasmids, all of the mutants were regulated by 8Br-cAMP or forskolin, as expected for the SCF gene, whereas FSH and TPA had no effect. Colforsin 136-145 KIT ligand Homo sapiens 167-170 8940364-11 1996 In SCF-luc plasmids extending to -853 or -2185, luciferase expression was still inducible by 8Br-cAMP and forskolin to high levels, but basal promoter activity was repressed to levels over 15-fold lower, in both the absence or presence of testosterone in the media for SF7 cells. Colforsin 106-115 KIT ligand Homo sapiens 3-6 8913880-12 1996 Also, forskolin decreased bradykinin-induced arachidonic acid release. Colforsin 6-15 kininogen 1 Bos taurus 26-36 8931487-7 1996 Forskolin treatment of the cells shifted Gs alpha protein toward the light-density membranes. Colforsin 0-9 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 41-49 9037523-3 1996 The peptide inhibited the forskolin-induced cyclic AMP accumulation in ROR-C expressing Chinese hamster ovary cells. Colforsin 26-35 nuclear receptor ROR-gamma Cricetulus griseus 71-76 9051743-4 1996 Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the delta opioid receptor is functional. Colforsin 72-81 interleukin 2 Mus musculus 13-17 9051743-4 1996 Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the delta opioid receptor is functional. Colforsin 72-81 interleukin 2 Homo sapiens 162-166 8943224-6 1996 Specific kinase assays revealed that forskolin partially inhibited phosphatidylinositol 3-kinase activity and completely blocked p70(S6)-kinase activity and phosphorylation. Colforsin 37-46 ubiquitin associated and SH3 domain containing, B Mus musculus 129-143 8960551-3 1996 Studies of inhibition of the forskolin-stimulated c-AMP formation mediated by the human 5-HT(1B) receptor (formerly the 5-HT(1Dbeta) receptor) demonstrate that all of these serotonin dimers behave as full agonists. Colforsin 29-38 5-hydroxytryptamine receptor 1B Homo sapiens 88-95 8958576-4 1996 Treatment of slices of rat prefrontal cortex and caudate-putamen with 5 microM forskolin plus 0.5 mM IBMX (3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor) caused a significant elevation of potassium-evoked CCK release. Colforsin 79-88 cholecystokinin Rattus norvegicus 218-221 8943957-5 1996 After infection with RAd35 beta-Gal at 30, 100, and 1000 plaque-forming units per cell (pfu/cell), expression of beta-galactosidase was augmented up to 17-, 19-, and 23-fold, respectively, in human VSMCs treated with forskolin and phorbol ester compared with unstimulated cells. Colforsin 217-226 galactosidase beta 1 Homo sapiens 113-131 8940368-4 1996 The effect of PTH was maximal at 1 h and decreased almost to control levels by 6 h. Phorbol myristate acetate (PMA), forskolin, and 8-bromo-cAMP increased PGHS-2 mRNA levels, whereas ionomycin had no effect. Colforsin 117-126 prostaglandin-endoperoxide synthase 2 Mus musculus 155-161 8940368-7 1996 However, treatment of cells with 30 microM H-89, a protein kinase A inhibitor, significantly reduced the ability of PTH and forskolin to induce PGHS-2 mRNA levels. Colforsin 124-133 prostaglandin-endoperoxide synthase 2 Mus musculus 144-150 8967989-3 1996 Forskolin-stimulated cAMP accumulation in the 293/DOR cells was dose-dependently suppressed by the delta-selective agonist [D-Pen2, D-Pen5]enkephalin, and such inhibition was abolished by pertussis toxin or the opiate antagonist naloxone. Colforsin 0-9 tumor protein p53 inducible nuclear protein 2 Homo sapiens 50-53 8967989-3 1996 Forskolin-stimulated cAMP accumulation in the 293/DOR cells was dose-dependently suppressed by the delta-selective agonist [D-Pen2, D-Pen5]enkephalin, and such inhibition was abolished by pertussis toxin or the opiate antagonist naloxone. Colforsin 0-9 presenilin enhancer, gamma-secretase subunit Homo sapiens 126-130 8967989-5 1996 The ICI-174,864-induced enhancement of the forskolin response exhibited dose-dependency and was antagonized by [D-Pen2,D-Pen5]enkephalin and blocked by pertussis toxin. Colforsin 43-52 presenilin enhancer, gamma-secretase subunit Homo sapiens 114-118 8961279-8 1996 Expression of the human ACTH receptor in Y6 and OS3 cells restored ACTH-responsive adenylyl cyclase activity and increased the level of Gs alpha, but did not otherwise reverse the forskolin-resistant phenotype. Colforsin 180-189 melanocortin 2 receptor Mus musculus 24-37 8961279-9 1996 Together, these results demonstrate that mutations to forskolin resistance have downstream consequences that result in the loss of ACTH receptor expression and the consequent reduction in levels of membrane-associated G alpha subunits. Colforsin 54-63 melanocortin 2 receptor Mus musculus 131-144 8961279-11 1996 According to current models, forskolin activates adenylyl cyclase by forming a ternary complex with adenylyl cyclase and Gs alpha. Colforsin 29-38 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 121-129 8941384-2 1996 In addition, the intrinsic efficacy was measured as the reduction of forskolin-stimulated cAMP in cells transfected with 5-HT1D alpha and 5-HT1D beta receptors in vitro. Colforsin 69-78 5-hydroxytryptamine receptor 1D Rattus norvegicus 121-127 8941384-2 1996 In addition, the intrinsic efficacy was measured as the reduction of forskolin-stimulated cAMP in cells transfected with 5-HT1D alpha and 5-HT1D beta receptors in vitro. Colforsin 69-78 5-hydroxytryptamine receptor 1D Rattus norvegicus 138-144 8955337-2 1996 By transfection analysis with a plasmid containing the -614/+804 human apoE gene fused to the secreted placental alkaline phosphatase (SPAP) reporter gene, we showed that the SPAP activity was decreased by 50% when HepG2 cells were incubated in the presence of db-cAMP or forskolin, indicating that this promoter region mediated this negative effect. Colforsin 272-281 apolipoprotein E Homo sapiens 71-75 8954139-6 1996 The elevation of [Ca2+]i induced by thrombin, STA2 or PGE2 was significantly suppressed by pretreatment of the cells with TPA (100 nM) as well as cAMP mimetics such as dibutyryl cAMP (5 mM), forskolin (5 microM) and iloprost (1 microM). Colforsin 191-200 coagulation factor II, thrombin Homo sapiens 36-44 8954139-3 1996 Addition of a thromboxane (TX)A2 mimetic (U46619 or STA2) or thrombin stimulated the formation of inositol phosphates and dose-dependently augmented a prostaglandin (PG)I2 mimetic (iloprost)- or forskolin-induced cAMP formation. Colforsin 195-204 coagulation factor II, thrombin Homo sapiens 61-69 8910605-4 1996 Moreover, prior cell exposure to TSH or forskolin increased their responsiveness to insulin, IGF-I, and IGF-II, as seen on DNA synthesis and activation of a common insulin/IGF signaling pathway. Colforsin 40-49 insulin Canis lupus familiaris 84-91 8910605-4 1996 Moreover, prior cell exposure to TSH or forskolin increased their responsiveness to insulin, IGF-I, and IGF-II, as seen on DNA synthesis and activation of a common insulin/IGF signaling pathway. Colforsin 40-49 insulin like growth factor 1 Canis lupus familiaris 93-98 8910605-4 1996 Moreover, prior cell exposure to TSH or forskolin increased their responsiveness to insulin, IGF-I, and IGF-II, as seen on DNA synthesis and activation of a common insulin/IGF signaling pathway. Colforsin 40-49 insulin Canis lupus familiaris 164-171 8941720-4 1996 Although both forskolin and Bt2 cAMP potently reduced background tyrosine phosphorylation of paxillin, they allowed Ang II to induce the same reaction. Colforsin 14-23 paxillin Homo sapiens 93-101 8947492-3 1996 With membranes from both clones, the opioid agonist [D-Ala2]leucine enkephalin (DADLE) caused stimulation of high-affinity GTPase activity and of the binding of guanosine 5"-[gamma-[35S]thio]triphosphate, and inhibition of forskolin-amplified adenylate cyclase activity. Colforsin 223-232 proenkephalin Rattus norvegicus 68-78 8944640-2 1996 In CFPAC-1 cells, adenosine 3",5"-cyclic monophosphate (cAMP) stimulation with forskolin (10 microM) plus 8-(4-chlorophenylthio)adenosine 3",5"-cyclic monophosphate (400 microM) activated neither Cl- nor K+ currents. Colforsin 79-88 cathelicidin antimicrobial peptide Homo sapiens 56-60 8944643-3 1996 Tyrosine phosphorylation of paxillin increased by three- to fourfold with a time course similar to force development during contractile stimulation with acetylcholine (ACh), 5-hydroxytryptamine, and KCl and decreased during washout of contractile stimuli and during relaxation induced by forskolin. Colforsin 288-297 paxillin Homo sapiens 28-36 8912883-3 1996 Cells precultured with dbcAMP or forskolin for 3 days did not proliferate or produce IL-2 in response to antigen and APC, but did proliferate to antigen and APC in the presence of IL-2. Colforsin 33-42 interleukin 2 Mus musculus 180-184 8945961-5 1996 An increase in intracellular adenosine 3",5"-cyclic monophosphate levels by forskolin (10 microM) diminished t-PA and PAI-1 levels 43 and 17%, respectively. Colforsin 76-85 plasminogen activator, tissue type Homo sapiens 109-113 8945961-5 1996 An increase in intracellular adenosine 3",5"-cyclic monophosphate levels by forskolin (10 microM) diminished t-PA and PAI-1 levels 43 and 17%, respectively. Colforsin 76-85 serpin family E member 1 Homo sapiens 118-123 8969900-6 1996 When transfected into Y-1 cells, reporter gene expression was increased following treatment with ACTH or forskolin, but not with Ang II, the L-type calcium channel agonist BAYK8644, or ionomycin. Colforsin 105-114 RNA, Ro60-associated Y1 Homo sapiens 22-25 8969909-3 1996 Androstenedione, cortisol and corticosterone secreted into the medium in response to a subsequent 4 hour treatment with angiotensin II (10nM) indicated that the steroidogenic phenotype of NCI-H295 cells changes away from 17-deoxysteroid biosynthesis towards adrenal androgen production in response to forskolin. Colforsin 301-310 angiotensinogen Homo sapiens 120-134 8863518-6 1996 Substance P, cholecystokinin, neurotensin, and brain natriuretic peptide also increased the level of expression along with phorbol 12-myristate 13-acetate and dibutyrylcyclic GMP, whereas forskolin and dibutyryl-cyclic AMP caused a decrease. Colforsin 188-197 tachykinin 1 Mus musculus 0-11 8895335-3 1996 We have shown that TSH and forskolin, which both induce proliferation and differentiation of the thyroid cells by activation of the protein kinase A pathway, lead to a strong and transient expression of two NGFI-B mRNA species, which differ in the length of the poly(A) tail. Colforsin 27-36 nuclear receptor subfamily 4 group A member 1 Canis lupus familiaris 207-213 8950104-10 1996 Unexpectedly, however, agonist which preferentially activate group II and III mGluRs increased both basal and forskolin-stimulated cAMP accumulation in GT1-7 cells. Colforsin 110-119 glutamyl-tRNA synthetase 2, mitochondrial Mus musculus 78-84 8933759-5 1996 Functional studies involved the inhibition of forskolin-stimulated cyclic adenosine monophosphate (cAMP) production, the stimulation of mitogen-activated protein (MAP) kinase activity, and the stimulation of mitotic activity as reflected by the expression of proliferating cell nuclear antigen (PCNA). Colforsin 46-55 proliferating cell nuclear antigen Homo sapiens 259-293 8933759-5 1996 Functional studies involved the inhibition of forskolin-stimulated cyclic adenosine monophosphate (cAMP) production, the stimulation of mitogen-activated protein (MAP) kinase activity, and the stimulation of mitotic activity as reflected by the expression of proliferating cell nuclear antigen (PCNA). Colforsin 46-55 proliferating cell nuclear antigen Homo sapiens 295-299 8933759-7 1996 The administration of the alpha 2-agonist, dexmedetomidine, to HTM cells resulted in a 90% inhibition of forskolin-stimulated cAMP formation, a twofold stimulation of MAP kinase activity, and a threefold increase in the expression of PCNA. Colforsin 105-114 proliferating cell nuclear antigen Homo sapiens 234-238 8908208-8 1996 Iloprost, dibutyryl cAMP, forskolin, or cholera toxin, when applied alone, enhanced [3H]thymidine incorporation, while they inhibited [3H]thymidine incorporation induced by submaximal concentrations of PGF2 alpha or epidermal growth factor (EGF), when applied within 12 hr after agonist stimulation. Colforsin 26-35 epidermal growth factor Mus musculus 216-239 8908208-8 1996 Iloprost, dibutyryl cAMP, forskolin, or cholera toxin, when applied alone, enhanced [3H]thymidine incorporation, while they inhibited [3H]thymidine incorporation induced by submaximal concentrations of PGF2 alpha or epidermal growth factor (EGF), when applied within 12 hr after agonist stimulation. Colforsin 26-35 epidermal growth factor Mus musculus 241-244 8895322-12 1996 PTH (10 and 100 nM) had no effect on the intracellular accumulation of cAMP at 34 C but stimulated a 14- to 18-fold increase in the production of this second messenger at 40 C. In contrast, 100 nM prostaglandin E2 and 1 microM forskolin stimulated cAMP synthesis better at 34 C. Western blot analysis indicated that the cells expressed CD44, a putative osteocytic marker, at both temperatures. Colforsin 227-236 parathyroid hormone Homo sapiens 0-3 8923870-6 1996 Forskolin treatment was also found to increase the expression of a human StAR proximal promoter-luciferase fusion gene transfected into the proliferating granulosa-lutein cells. Colforsin 0-9 steroidogenic acute regulatory protein Homo sapiens 73-77 8863492-6 1996 Forskolin-mediated induction of the reporter gene in SH-EP and SK-N-SH cells was completely abolished by mutations in the VIP-CRE but not by deletion of the upstream sequence, indicating that the VIP-CRE alone determines cyclic AMP responsiveness. Colforsin 0-9 vasoactive intestinal peptide Homo sapiens 122-125 8863492-6 1996 Forskolin-mediated induction of the reporter gene in SH-EP and SK-N-SH cells was completely abolished by mutations in the VIP-CRE but not by deletion of the upstream sequence, indicating that the VIP-CRE alone determines cyclic AMP responsiveness. Colforsin 0-9 vasoactive intestinal peptide Homo sapiens 196-199 8939455-12 1996 In addition, forskolin decreased the outgrowth of postcrush retinal explants in a dose-dependent manner, suggesting the importance of critical levels of cAMP in this process. Colforsin 13-22 cathelicidin antimicrobial peptide Rattus norvegicus 153-157 8946564-12 1996 Forskolin (FK) alone inhibited postnuclear PTK activity and stimulated its nuclear activity. Colforsin 0-9 protein tyrosine kinase 2 beta Homo sapiens 43-46 8945089-9 1996 In animals with minor infarction (n = 7, LVEDP = 7.7 +/- 0.9 mmHg), forskolin (3 mumol/L) increased the maximal available INa+ to 109% +/- 13% of baseline values. Colforsin 68-77 internexin neuronal intermediate filament protein, alpha Rattus norvegicus 122-125 8901608-7 1996 However, in CFTR-expressing cells activated by forskolin, ffusion was increased by 1.30 +/- 0.18- and 2.65 +/- 0.17-fold for a 0 and 10 min chase time between avidin and biotin-albumin pulses; f(fusion) also increased (1.32 +/- 0.11-fold) when biotin-transferrin replaced biotin-albumin. Colforsin 47-56 CF transmembrane conductance regulator Homo sapiens 12-16 8901608-7 1996 However, in CFTR-expressing cells activated by forskolin, ffusion was increased by 1.30 +/- 0.18- and 2.65 +/- 0.17-fold for a 0 and 10 min chase time between avidin and biotin-albumin pulses; f(fusion) also increased (1.32 +/- 0.11-fold) when biotin-transferrin replaced biotin-albumin. Colforsin 47-56 transferrin Homo sapiens 251-262 8810303-10 1996 Forskolin stimulation of PC12 cells and reserpine treatment of rats increased, in nuclear extracts derived from cells and adrenal glands, respectively, the amount of a fast moving CRE/protein complex that was supershifted by an anti-CREM antibody. Colforsin 0-9 cAMP responsive element modulator Rattus norvegicus 233-237 8914576-3 1996 In Chinese hamster ovary (CHO) cells expressing the mouse NPY-Y2 receptor, an increase in intracellular Ca2+ and inhibition of forskolin-induced cAMP accumulation were observed due to stimulation with NPY, NPY-(13-36) and peptide YY, but not with pancreatic polypeptide or [Leu31, Pro34]NPY. Colforsin 127-136 neuropeptide Y receptor Y2 Mus musculus 58-73 8914576-3 1996 In Chinese hamster ovary (CHO) cells expressing the mouse NPY-Y2 receptor, an increase in intracellular Ca2+ and inhibition of forskolin-induced cAMP accumulation were observed due to stimulation with NPY, NPY-(13-36) and peptide YY, but not with pancreatic polypeptide or [Leu31, Pro34]NPY. Colforsin 127-136 neuropeptide Y Mus musculus 58-61 8914576-3 1996 In Chinese hamster ovary (CHO) cells expressing the mouse NPY-Y2 receptor, an increase in intracellular Ca2+ and inhibition of forskolin-induced cAMP accumulation were observed due to stimulation with NPY, NPY-(13-36) and peptide YY, but not with pancreatic polypeptide or [Leu31, Pro34]NPY. Colforsin 127-136 neuropeptide Y Mus musculus 201-204 8914576-3 1996 In Chinese hamster ovary (CHO) cells expressing the mouse NPY-Y2 receptor, an increase in intracellular Ca2+ and inhibition of forskolin-induced cAMP accumulation were observed due to stimulation with NPY, NPY-(13-36) and peptide YY, but not with pancreatic polypeptide or [Leu31, Pro34]NPY. Colforsin 127-136 neuropeptide Y Mus musculus 201-204 8914576-4 1996 The fact that the NPY-induced increase in intracellular Ca2+ and inhibition of forskolin-induced cAMP accumulation were eliminated by pretreatment with pertussis toxin suggests that the NPY-Y2 receptor couples to PTX-sensitive G-protein(s), probably Gi/Go, in CHO cells. Colforsin 79-88 pro-neuropeptide Y Cricetulus griseus 18-21 8914576-4 1996 The fact that the NPY-induced increase in intracellular Ca2+ and inhibition of forskolin-induced cAMP accumulation were eliminated by pretreatment with pertussis toxin suggests that the NPY-Y2 receptor couples to PTX-sensitive G-protein(s), probably Gi/Go, in CHO cells. Colforsin 79-88 neuropeptide Y Mus musculus 186-189 8912813-4 1996 Melatonin was able to significantly inhibit forskolin-stimulated induction of c-fos and jun B mRNA whilst forskolin had no effect upon c-jun or jun D. Colforsin 44-53 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 78-83 8912813-4 1996 Melatonin was able to significantly inhibit forskolin-stimulated induction of c-fos and jun B mRNA whilst forskolin had no effect upon c-jun or jun D. Colforsin 44-53 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 88-93 8912813-5 1996 Induction of c-Fos translation by forskolin was also inhibited by melatonin. Colforsin 34-43 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 13-18 8961254-10 1996 We conclude that StAR message is expressed only in the steroidogenic rat granulosa cells and can be upregulated by FSH, hCG, isoproterenol and forskolin in the appropriate cell lines. Colforsin 143-152 steroidogenic acute regulatory protein Rattus norvegicus 17-21 8921165-4 1996 Forskolin exposure of CFPAC-1 cells, containing delta F508 CFTR, and CFPAC-1 PLJ4.7 cells, transfected with WT-CFTR stimulated Cl- secretion only from the latter, showing that the assay can be used to measure CFTR function. Colforsin 0-9 CF transmembrane conductance regulator Homo sapiens 59-63 8831588-7 1996 IL-10 reversed, or markedly attenuated, forskolin- and carbachol-induced net chloride secretion. Colforsin 40-49 interleukin 10 Rattus norvegicus 0-5 8831588-8 1996 The effects of IL-10 on net secretion were accompanied by a reduction in forskolin-stimulated cAMP levels and a decrease in basal cAMP levels. Colforsin 73-82 interleukin 10 Rattus norvegicus 15-20 8855796-11 1996 Indeed, Bu2cAMP and forskolin, known to decrease iodide organification in human thyroid, inhibited the PLD stimulation induced by ATP and PDBu. Colforsin 20-29 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 103-106 8812149-3 1996 The cultures were maintained in either control medium or medium containing the cAMP elevating drugs, IBMX (3-isobutyl-1-methylxanthine), and forskolin for 23 or 30 days of culture to induce VP synthesis and secretion. Colforsin 141-150 arginine vasopressin Rattus norvegicus 190-192 8812149-5 1996 Administration of VP mRNA to the cultures treated continuously with IBMX and forskolin also resulted in a small increase in VP secretion which did not reach significance after either 6 or 24 h. When cultures prepared with continuous I/F were exposed to antisense VP mRNA, VP secretion into the media was decreased by 58%, and VP immunoreactive perikayra were difficult to observe. Colforsin 77-86 arginine vasopressin Rattus norvegicus 18-20 8812149-5 1996 Administration of VP mRNA to the cultures treated continuously with IBMX and forskolin also resulted in a small increase in VP secretion which did not reach significance after either 6 or 24 h. When cultures prepared with continuous I/F were exposed to antisense VP mRNA, VP secretion into the media was decreased by 58%, and VP immunoreactive perikayra were difficult to observe. Colforsin 77-86 arginine vasopressin Rattus norvegicus 124-126 8812149-5 1996 Administration of VP mRNA to the cultures treated continuously with IBMX and forskolin also resulted in a small increase in VP secretion which did not reach significance after either 6 or 24 h. When cultures prepared with continuous I/F were exposed to antisense VP mRNA, VP secretion into the media was decreased by 58%, and VP immunoreactive perikayra were difficult to observe. Colforsin 77-86 arginine vasopressin Rattus norvegicus 124-126 8812149-5 1996 Administration of VP mRNA to the cultures treated continuously with IBMX and forskolin also resulted in a small increase in VP secretion which did not reach significance after either 6 or 24 h. When cultures prepared with continuous I/F were exposed to antisense VP mRNA, VP secretion into the media was decreased by 58%, and VP immunoreactive perikayra were difficult to observe. Colforsin 77-86 arginine vasopressin Rattus norvegicus 124-126 8812149-5 1996 Administration of VP mRNA to the cultures treated continuously with IBMX and forskolin also resulted in a small increase in VP secretion which did not reach significance after either 6 or 24 h. When cultures prepared with continuous I/F were exposed to antisense VP mRNA, VP secretion into the media was decreased by 58%, and VP immunoreactive perikayra were difficult to observe. Colforsin 77-86 arginine vasopressin Rattus norvegicus 124-126 8889836-8 1996 The opposite effect of PTH, observed between the preconfluent and the postconfluent state, was reproduced by adding dibutyryl cyclic adenosine monophosphate (cAMP) or forskolin, but not by adding phorbol myristate acetate. Colforsin 167-176 parathyroid hormone Mus musculus 23-26 8921165-4 1996 Forskolin exposure of CFPAC-1 cells, containing delta F508 CFTR, and CFPAC-1 PLJ4.7 cells, transfected with WT-CFTR stimulated Cl- secretion only from the latter, showing that the assay can be used to measure CFTR function. Colforsin 0-9 CF transmembrane conductance regulator Homo sapiens 111-115 8974059-4 1996 The hypertrophic effect of the non-specific beta-adrenoceptor agonist isoprenaline was abolished in presence of a specific beta 2-adrenoceptor antagonist (ICI 118,551), could be mimicked by use of a beta 2-adrenoceptor agonist (procaterol) or direct stimulation of adenylate cyclase (forskolin) or addition of a cell-permeable analogue of cAMP (dibuytyrylcyclo-AMP). Colforsin 284-293 adrenoceptor beta 2 Rattus norvegicus 123-142 8858999-5 1996 cAMP-elevating agents, such as PGE2, forskolin and dibutyryl cAMP, suppressed IL-2, IL-4 and IL-5 production by concanavalin A-stimulated PBMC in a manner similar to that of T-440. Colforsin 37-46 interleukin 2 Homo sapiens 78-82 8858999-5 1996 cAMP-elevating agents, such as PGE2, forskolin and dibutyryl cAMP, suppressed IL-2, IL-4 and IL-5 production by concanavalin A-stimulated PBMC in a manner similar to that of T-440. Colforsin 37-46 interleukin 4 Homo sapiens 84-88 8858999-5 1996 cAMP-elevating agents, such as PGE2, forskolin and dibutyryl cAMP, suppressed IL-2, IL-4 and IL-5 production by concanavalin A-stimulated PBMC in a manner similar to that of T-440. Colforsin 37-46 interleukin 5 Homo sapiens 93-97 8887269-10 1996 Ang IV stimulated cAMP production by intact HCD cells in the presence of forskolin but did not modify cGMP production or cytosolic calcium concentration. Colforsin 73-82 angiogenin Homo sapiens 0-3 8863849-1 1996 We previously reported that in Chinese hamster ovary (CHO) cells, 5-hydroxytryptamine (5-HT)1B-like (CHO/5-HT1B) receptor-mediated inhibition of forskolin-stimulated cAMP accumulation is inhibited by activation of transfected human 5-HT2C receptors but not 5-HT2A receptors. Colforsin 145-154 5-hydroxytryptamine receptor 2C Homo sapiens 232-238 8863849-1 1996 We previously reported that in Chinese hamster ovary (CHO) cells, 5-hydroxytryptamine (5-HT)1B-like (CHO/5-HT1B) receptor-mediated inhibition of forskolin-stimulated cAMP accumulation is inhibited by activation of transfected human 5-HT2C receptors but not 5-HT2A receptors. Colforsin 145-154 5-hydroxytryptamine receptor 2A Cricetulus griseus 257-263 8899638-27 1996 Activation of PKA by the adenylate cyclase activator forskolin led to inhibition of IAHP. Colforsin 53-62 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 14-17 8910214-11 1996 ACh and TPA also inhibited fluid secretion stimulated by the adenylate cyclase activator, forskolin. Colforsin 90-99 acyl-CoA thioesterase 12 Rattus norvegicus 0-3 8974059-4 1996 The hypertrophic effect of the non-specific beta-adrenoceptor agonist isoprenaline was abolished in presence of a specific beta 2-adrenoceptor antagonist (ICI 118,551), could be mimicked by use of a beta 2-adrenoceptor agonist (procaterol) or direct stimulation of adenylate cyclase (forskolin) or addition of a cell-permeable analogue of cAMP (dibuytyrylcyclo-AMP). Colforsin 284-293 adrenoceptor beta 2 Rattus norvegicus 199-218 8855340-7 1996 In addition, activators of protein kinase A, including forskolin and 8-Br-cAMP, which are known to inhibit ERK-mediated events, also inhibited urea-inducible Egr-1 transcription. Colforsin 55-64 mitogen-activated protein kinase 1 Mus musculus 107-110 8923515-4 1996 The proENK mRNA level began to increase within an hour, then reached and remained at a peak 3-12 h after stimulation by both forskolin and PMA. Colforsin 125-134 proenkephalin Rattus norvegicus 4-10 8923515-5 1996 The increased proENK mRNA level in forskolin-treated cells was slightly decreased 24 h after the stimulation, whereas the level of proENK mRNA returned to basal levels in PMA-treated cells. Colforsin 35-44 proenkephalin Rattus norvegicus 14-20 8923515-11 1996 Calcium influx through both L- and N-type calcium channels, calmodulin and Ca2+/calmodulin-dependent protein kinase II appear to be involved in the increase of proENK mRNA levels induced by either forskolin or PMA. Colforsin 197-206 proenkephalin Rattus norvegicus 160-166 8884849-8 1996 Forskolin, the PKA activator 5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole-3, 5-monophosphorothiotate, and GLP-I stabilized the GLP-I receptor mRNA. Colforsin 0-9 granzyme B Rattus norvegicus 132-137 8855340-7 1996 In addition, activators of protein kinase A, including forskolin and 8-Br-cAMP, which are known to inhibit ERK-mediated events, also inhibited urea-inducible Egr-1 transcription. Colforsin 55-64 early growth response 1 Mus musculus 158-163 8798479-5 1996 The intracellular interaction of PKA, GMF, and p38 is supported by the phosphorylation of GMF upon cellular stimulation by forskolin (blocked by PKA inhibitor) and by the co-immunoprecipitation of p38 with GMF from cell lysates. Colforsin 123-132 glia maturation factor beta Homo sapiens 38-41 8798479-5 1996 The intracellular interaction of PKA, GMF, and p38 is supported by the phosphorylation of GMF upon cellular stimulation by forskolin (blocked by PKA inhibitor) and by the co-immunoprecipitation of p38 with GMF from cell lysates. Colforsin 123-132 mitogen-activated protein kinase 14 Homo sapiens 47-50 8798479-5 1996 The intracellular interaction of PKA, GMF, and p38 is supported by the phosphorylation of GMF upon cellular stimulation by forskolin (blocked by PKA inhibitor) and by the co-immunoprecipitation of p38 with GMF from cell lysates. Colforsin 123-132 glia maturation factor beta Homo sapiens 90-93 8798479-5 1996 The intracellular interaction of PKA, GMF, and p38 is supported by the phosphorylation of GMF upon cellular stimulation by forskolin (blocked by PKA inhibitor) and by the co-immunoprecipitation of p38 with GMF from cell lysates. Colforsin 123-132 glia maturation factor beta Homo sapiens 90-93 8891583-8 1996 Moreover, incubation of eosinophils with the adenylate cyclase activator forskolin (1-100 microM), while inducing a discrete increase in cyclic AMP, markedly inhibited PAF- and leukotriene B4-induced eosinophil chemotaxis. Colforsin 73-82 PCNA clamp associated factor Rattus norvegicus 168-171 8816777-7 1996 The CFTR protein was present at the apical surfaces of cyst epithelial cells that had been stimulated to secrete through incubation in forskolin. Colforsin 135-144 CF transmembrane conductance regulator Homo sapiens 4-8 8816777-8 1996 CFTR was detected in intracellular structures in cultured cyst epithelial cells that had not received the forskolin treatment. Colforsin 106-115 CF transmembrane conductance regulator Homo sapiens 0-4 8891583-9 1996 Eosinophils treated with a combination of individually inactive amounts of forskolin plus rolipram significantly inhibited the eosinophil migration elicited by PAF and leukotriene B4, but did not change cyclic AMP baseline levels. Colforsin 75-84 PCNA clamp associated factor Rattus norvegicus 160-163 8836153-6 1996 Each of NaF, forskolin and guanosine 5"-[beta, gamma-imido]triphosphate (a poorly hydrolysed analogue of GTP) produced substantially higher levels of adenylate cyclase activity in membranes of the clones positive for expression of adenylate cyclase type II than was achieved with the parental cells. Colforsin 13-22 adenylate cyclase 2 Mus musculus 231-256 8836145-7 1996 Raising intracellular cAMP levels using forskolin, however, resulted in a marked time-dependent inhibition of p70s6k activity, a decrease in the tyrosine phosphorylation of the PtdIns 3-kinase p85 subunit and reduced PtdIns 3-kinase activity. Colforsin 40-49 cathelicidin-7 Bos taurus 22-26 8765477-3 1996 Culture of islets at 5.5 mM glucose for 2 days in the presence of forskolin, 3-isobutylmethylxanthine (IBMX), and 8-bromo-cyclic AMP also significantly increased G3PD activity compared with control islets, although there was no change in enzyme activity after only 1 day of culture with forskolin. Colforsin 66-75 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 162-166 8836145-7 1996 Raising intracellular cAMP levels using forskolin, however, resulted in a marked time-dependent inhibition of p70s6k activity, a decrease in the tyrosine phosphorylation of the PtdIns 3-kinase p85 subunit and reduced PtdIns 3-kinase activity. Colforsin 40-49 ribosomal protein S6 kinase B1 Bos taurus 110-116 8765477-3 1996 Culture of islets at 5.5 mM glucose for 2 days in the presence of forskolin, 3-isobutylmethylxanthine (IBMX), and 8-bromo-cyclic AMP also significantly increased G3PD activity compared with control islets, although there was no change in enzyme activity after only 1 day of culture with forskolin. Colforsin 287-296 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 162-166 8765477-4 1996 Treatment with forskolin was associated with an increase in the Vmax of G3PD, but no change was observed in the apparent K(m) with NAD. Colforsin 15-24 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 72-76 8795615-4 1996 The dnc phenotype could be mimicked by normal neurons when perfused with dibutyryl cAMP (db-cAMP) or forskolin. Colforsin 101-110 dunce Drosophila melanogaster 4-7 8891268-5 1996 This was in contrast to forskolin + phorbol 12 myristate 13-acetate (PMA) which were highly effective in inducing NPY production, verifying that expression of NPY is a regulated process in these cultures. Colforsin 24-33 neuropeptide Y Rattus norvegicus 114-117 8891268-5 1996 This was in contrast to forskolin + phorbol 12 myristate 13-acetate (PMA) which were highly effective in inducing NPY production, verifying that expression of NPY is a regulated process in these cultures. Colforsin 24-33 neuropeptide Y Rattus norvegicus 159-162 8891268-8 1996 Moreover, the effects of BDNF or NT-4/5 and forskolin + PMA on NPY production were additive, indicating the involvement of distinct intracellular signalling pathways. Colforsin 44-53 neuropeptide Y Rattus norvegicus 63-66 8853375-3 1996 Time course analysis revealed that IBMX and forskolin reduced the VP mRNA content to 50% of control explants after 8 and 12 h despite a dramatic stimulation of VP release. Colforsin 44-53 arginine vasopressin Homo sapiens 66-68 8853375-3 1996 Time course analysis revealed that IBMX and forskolin reduced the VP mRNA content to 50% of control explants after 8 and 12 h despite a dramatic stimulation of VP release. Colforsin 44-53 arginine vasopressin Homo sapiens 160-162 8853375-4 1996 This effect was due to the activation of adenyl cyclase by forskolin, because neither IBMX alone nor the inactive analogue of forskolin, 1,9-dideoxyforskolin, decreased VP mRNA content. Colforsin 59-68 arginine vasopressin Homo sapiens 169-171 8853375-6 1996 This was confirmed when forskolin (10 microM) was found to increase VP mRNA content. Colforsin 24-33 arginine vasopressin Homo sapiens 68-70 8702997-4 1996 Treatment of aorta with the adenyl cyclase activator, forskolin, also demonstrated increased phosphorylation of the IP3 receptor on the PKG site, although the selective cAMP-dependent protein kinase activator, 8-(4-para-chlorophenylthio)-cAMP (8-CPT-cAMP), did not increase the phosphorylation of the IP3 receptor. Colforsin 54-63 inositol 1,4,5-trisphosphate receptor, type 3 Rattus norvegicus 116-128 8702997-4 1996 Treatment of aorta with the adenyl cyclase activator, forskolin, also demonstrated increased phosphorylation of the IP3 receptor on the PKG site, although the selective cAMP-dependent protein kinase activator, 8-(4-para-chlorophenylthio)-cAMP (8-CPT-cAMP), did not increase the phosphorylation of the IP3 receptor. Colforsin 54-63 inositol 1,4,5-trisphosphate receptor, type 3 Rattus norvegicus 301-313 8702997-5 1996 Moreover, the PKG selective inhibitor, KT 5823, inhibited both sodium nitroprusside and forskolin-induced IP3 receptor phosphorylation more potently than the selective cAMP-dependent protein kinase inhibitor, KT 5720, suggesting that PKG mediates the increase in IP3 receptor phosphorylation by both cyclic nucleotides in intact aorta. Colforsin 88-97 inositol 1,4,5-trisphosphate receptor, type 3 Rattus norvegicus 106-118 8702997-5 1996 Moreover, the PKG selective inhibitor, KT 5823, inhibited both sodium nitroprusside and forskolin-induced IP3 receptor phosphorylation more potently than the selective cAMP-dependent protein kinase inhibitor, KT 5720, suggesting that PKG mediates the increase in IP3 receptor phosphorylation by both cyclic nucleotides in intact aorta. Colforsin 88-97 inositol 1,4,5-trisphosphate receptor, type 3 Rattus norvegicus 263-275 8876753-14 1996 NPY attenuated forskolin-stimulated cAMP production in renal tubules and exogenous cAMP counteracted the NPY-stimulated Na+,K(+)-ATPase activity. Colforsin 15-24 neuropeptide Y Rattus norvegicus 0-3 8809060-7 1996 The differential inhibition of MAP kinase activation by forskolin was not due to specific activation of A-Raf by PDGF; both PDGF and AII stimulated A-Raf kinase and this activity was strongly inhibited by forskolin. Colforsin 56-65 angiotensinogen Rattus norvegicus 133-136 8809060-7 1996 The differential inhibition of MAP kinase activation by forskolin was not due to specific activation of A-Raf by PDGF; both PDGF and AII stimulated A-Raf kinase and this activity was strongly inhibited by forskolin. Colforsin 205-214 angiotensinogen Rattus norvegicus 133-136 8809060-7 1996 The differential inhibition of MAP kinase activation by forskolin was not due to specific activation of A-Raf by PDGF; both PDGF and AII stimulated A-Raf kinase and this activity was strongly inhibited by forskolin. Colforsin 205-214 A-Raf proto-oncogene, serine/threonine kinase Rattus norvegicus 148-153