PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21237683-1	2011	Long-chain fatty acids are an important source of energy in muscle and heart where the acyl-CoA dehydrogenases (ACADs) participate in consecutive cycles of beta-oxidation to generate acetyl-CoA and reducing equivalents for generating energy.	long-chain fatty acids	0-22	acyl-CoA dehydrogenase short chain	Homo sapiens	87-110
21237683-1	2011	Long-chain fatty acids are an important source of energy in muscle and heart where the acyl-CoA dehydrogenases (ACADs) participate in consecutive cycles of beta-oxidation to generate acetyl-CoA and reducing equivalents for generating energy.	long-chain fatty acids	0-22	acyl-CoA dehydrogenase short chain	Homo sapiens	112-117
21245374-1	2011	Long-chain acyl coenzyme A (acyl-CoA) synthetase isoform 1 (ACSL1) catalyzes the synthesis of acyl-CoA from long-chain fatty acids and contributes the majority of cardiac long-chain acyl-CoA synthetase activity.	long-chain fatty acids	108-130	acyl-CoA synthetase long-chain family member 1	Mus musculus	60-65
21184843-3	2011	METHODS: Rat Acsl3-, Acsl6v1- and Acsl6v2-, and Acsl4-flag proteins were expressed in E. coli, and the ability of VPA to inhibit their activation of long-chain fatty acids to acyl-CoA was estimated using Michaelis-Menten kinetics.	long-chain fatty acids	149-171	acyl-CoA synthetase long-chain family member 4	Rattus norvegicus	48-53
21294903-3	2011	The current study examined breast cancer as a metabolic disease in the context of altered fatty acid catabolism by examining the effect of PRL on carnitine palmitoyl transferase 1 (CPT1), an enzyme that shuttles long-chain fatty acids into the mitochondrial matrix for beta-oxidation.	long-chain fatty acids	212-234	prolactin	Homo sapiens	139-142
21307243-1	2011	Acyl-CoA synthetase long-chain family member 4 (ACSL4) converts long-chain fatty acids to acyl-CoAs that are indispensable for lipid metabolism and cell signaling.	long-chain fatty acids	64-86	acyl-CoA synthetase long chain family member 4	Homo sapiens	48-53
21294903-3	2011	The current study examined breast cancer as a metabolic disease in the context of altered fatty acid catabolism by examining the effect of PRL on carnitine palmitoyl transferase 1 (CPT1), an enzyme that shuttles long-chain fatty acids into the mitochondrial matrix for beta-oxidation.	long-chain fatty acids	212-234	carnitine palmitoyltransferase 1A	Homo sapiens	181-185
21041072-1	2011	We found previously that long-chain fatty-acid-CoA ligase 3 (FACL3), a critical enzyme for activation of long-chain fatty acids, was upregulated by 1alpha, 25(OH)(2)D(3) at an mRNA and enzyme activity levels in prostate cancer cells.	long-chain fatty acids	105-127	acyl-CoA synthetase long chain family member 3	Homo sapiens	25-59
21106902-1	2011	ELOVL2 is a member of the mammalian microsomal ELOVL fatty acid enzyme family, involved in the elongation of very long-chain fatty acids including PUFAs required for various cellular functions in mammals.	long-chain fatty acids	114-136	ELOVL fatty acid elongase 2	Homo sapiens	0-6
21041072-1	2011	We found previously that long-chain fatty-acid-CoA ligase 3 (FACL3), a critical enzyme for activation of long-chain fatty acids, was upregulated by 1alpha, 25(OH)(2)D(3) at an mRNA and enzyme activity levels in prostate cancer cells.	long-chain fatty acids	105-127	acyl-CoA synthetase long chain family member 3	Homo sapiens	61-66
20601113-0	2010	Expression and role of Elovl4 elongases in biosynthesis of very long-chain fatty acids during zebrafish Danio rerio early embryonic development.	long-chain fatty acids	64-86	ELOVL fatty acid elongase 4b	Danio rerio	23-29
21139992-1	2010	PURPOSE: Stargardt disease 3 (STGD3) is a juvenile macular dystrophy caused by mutations in the elongase of very long-chain fatty acids-like 4 (ELOVL4) gene, which encodes an elongase involved in the production of extremely long-chain fatty acids.	long-chain fatty acids	113-135	ELOVL fatty acid elongase 4	Homo sapiens	30-35
21139992-1	2010	PURPOSE: Stargardt disease 3 (STGD3) is a juvenile macular dystrophy caused by mutations in the elongase of very long-chain fatty acids-like 4 (ELOVL4) gene, which encodes an elongase involved in the production of extremely long-chain fatty acids.	long-chain fatty acids	113-135	ELOVL fatty acid elongase 4	Homo sapiens	144-150
21139992-1	2010	PURPOSE: Stargardt disease 3 (STGD3) is a juvenile macular dystrophy caused by mutations in the elongase of very long-chain fatty acids-like 4 (ELOVL4) gene, which encodes an elongase involved in the production of extremely long-chain fatty acids.	long-chain fatty acids	224-246	ELOVL fatty acid elongase 4	Homo sapiens	30-35
21139992-1	2010	PURPOSE: Stargardt disease 3 (STGD3) is a juvenile macular dystrophy caused by mutations in the elongase of very long-chain fatty acids-like 4 (ELOVL4) gene, which encodes an elongase involved in the production of extremely long-chain fatty acids.	long-chain fatty acids	224-246	ELOVL fatty acid elongase 4	Homo sapiens	144-150
20709688-3	2010	We screened for mutants showing resistance to this drug, and found that a lack of ELO3, the gene involved in synthesis of very long-chain fatty acids, confers resistance to the inhibitor.	long-chain fatty acids	127-149	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	82-86
21035124-4	2010	Recent interest in the role played by VLC-PUFA arose from the findings that a protein called elongation of very-long-chain fatty acids 4 (ELOVL4) is involved in their biosynthesis and that mutations in the ELOVL4 gene are associated with Stargardt-like macular dystrophy (STD3), a dominantly inherited juvenile macular degeneration leading to vision loss.	long-chain fatty acids	112-134	ELOVL fatty acid elongase 4	Homo sapiens	138-144
21035124-4	2010	Recent interest in the role played by VLC-PUFA arose from the findings that a protein called elongation of very-long-chain fatty acids 4 (ELOVL4) is involved in their biosynthesis and that mutations in the ELOVL4 gene are associated with Stargardt-like macular dystrophy (STD3), a dominantly inherited juvenile macular degeneration leading to vision loss.	long-chain fatty acids	112-134	ELOVL fatty acid elongase 4	Homo sapiens	206-212
20601113-1	2010	Elovl4 is a fatty acyl elongase that participates in the biosynthesis of very long-chain fatty acids (>/=C24), which are relatively abundant in skin (saturated chains), or retina, brain and testes (polyunsaturated chains) of mammals.	long-chain fatty acids	78-100	ELOVL fatty acid elongase 4b	Danio rerio	0-6
20179078-2	2010	It results from the functional loss of a member of the peroxisomal ATP-binding cassette transporter subfamily D (ABCD1), which is involved in the metabolism of very long-chain fatty acids (VLCFA).	long-chain fatty acids	165-187	ATP binding cassette subfamily D member 1	Homo sapiens	113-118
20633576-4	2010	An autosomal dominant form of Stargardt disease also known as Stargardt-like dystrophy is caused by mutations in a gene encoding ELOVL4, an enzyme that catalyzes the elongation of very long-chain fatty acids in photoreceptors and other tissues.	long-chain fatty acids	185-207	ELOVL fatty acid elongase 4	Homo sapiens	129-135
20173212-1	2010	Childhood adrenoleukodystrophy (cALD) is a metabolic disorder in which very long-chain fatty acids (VLCFA) accumulate due to ALD protein gene defects, ultimately leading to lipotoxicity-induced neuroinflammatory demyelinating disease.	long-chain fatty acids	76-98	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	33-36
20345608-3	2010	PED3 is involved in the import of several biologically important molecules into the peroxisome, including very-long-chain fatty acids associated with the breakdown of seed-reserve lipids, and precursors of auxin and jasmonic acid.	long-chain fatty acids	111-133	peroxisomal ABC transporter 1	Arabidopsis thaliana	0-4
20543519-13	2010	CONCLUSION: Ezetimibe alone reduces PHTG by blocking both the absorption of cholesterol and the intracellular trafficking and metabolism of long-chain fatty acids in enterocytes, resulting in the reduction of the formation of ApoB-48 which is necessary for the ApoB48-containing lipoprotein production in the small intestines.	long-chain fatty acids	140-162	apolipoprotein B	Mus musculus	226-233
20816094-2	2010	It closely resembles very long-chain acyl-CoA dehydrogenase (VLCAD), involved in mitochondrial beta oxidation of long-chain fatty acids.	long-chain fatty acids	113-135	acyl-CoA dehydrogenase very long chain	Homo sapiens	21-59
20816094-2	2010	It closely resembles very long-chain acyl-CoA dehydrogenase (VLCAD), involved in mitochondrial beta oxidation of long-chain fatty acids.	long-chain fatty acids	113-135	acyl-CoA dehydrogenase very long chain	Homo sapiens	61-66
20626743-1	2010	X-adrenoleukodystrophy (X-ALD) is a metabolic, peroxisomal disease affecting the nervous system, adrenal cortex and testis resulting from inactivating mutations in ABCD1 gene which encodes a peroxisomal membrane half-adenosine triphosphate (ATP)-binding cassette transporter, ABCD1 (or ALDP), whose defect is associated with impaired peroxisomal beta-oxidation and accumulation of saturated very long-chain fatty acids (VLCFA) in tissues and body fluids.	long-chain fatty acids	396-418	ATP binding cassette subfamily D member 1	Homo sapiens	164-169
20626744-5	2010	Furthermore, we pay special attention to the role of the VLCFA elongation system in VLCFA homeostasis, with elongation of very long-chain fatty acids like-1 (ELOVL1) as key player, and its relevance to X-ALD.	long-chain fatty acids	127-149	ELOVL fatty acid elongase 1	Homo sapiens	158-164
20040693-10	2010	Importantly, LPL also acts to assure delivery of long-chain fatty acids (LCFA) to milk.	long-chain fatty acids	49-71	lipoprotein lipase	Mus musculus	13-16
20159858-2	2010	Increased long-chain fatty acids, in particular saturated fatty acids, induce ER stress, Chop expression, and apoptosis in liver cells.	long-chain fatty acids	10-32	DNA-damage inducible transcript 3	Rattus norvegicus	89-93
20067991-1	2010	Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids, is involved in both normal lipid synthesis and cancer development.	long-chain fatty acids	58-80	fatty acid synthase	Homo sapiens	0-19
20067991-1	2010	Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids, is involved in both normal lipid synthesis and cancer development.	long-chain fatty acids	58-80	fatty acid synthase	Homo sapiens	21-25
19837920-9	2010	CONCLUSION: Generation of long-chain fatty acids through hydrolysis of fat is a critical step for fat-induced stimulation of GLP-1 in humans; the signal is mediated via CCK release and CCK-1 receptors.	long-chain fatty acids	26-48	glucagon	Homo sapiens	125-130
19837920-9	2010	CONCLUSION: Generation of long-chain fatty acids through hydrolysis of fat is a critical step for fat-induced stimulation of GLP-1 in humans; the signal is mediated via CCK release and CCK-1 receptors.	long-chain fatty acids	26-48	cholecystokinin	Homo sapiens	169-172
19837920-9	2010	CONCLUSION: Generation of long-chain fatty acids through hydrolysis of fat is a critical step for fat-induced stimulation of GLP-1 in humans; the signal is mediated via CCK release and CCK-1 receptors.	long-chain fatty acids	26-48	cholecystokinin	Homo sapiens	185-188
20035485-1	2010	Since liver fatty acid binding protein (L-FABP) facilitates uptake/oxidation of long-chain fatty acids in cultured transfected cells and primary hepatocytes, loss of L-FABP was expected to exacerbate weight gain and/or obesity in response to high dietary fat.	long-chain fatty acids	80-102	fatty acid binding protein 1, liver	Mus musculus	6-38
20035485-1	2010	Since liver fatty acid binding protein (L-FABP) facilitates uptake/oxidation of long-chain fatty acids in cultured transfected cells and primary hepatocytes, loss of L-FABP was expected to exacerbate weight gain and/or obesity in response to high dietary fat.	long-chain fatty acids	80-102	fatty acid binding protein 1, liver	Mus musculus	40-46
20035485-1	2010	Since liver fatty acid binding protein (L-FABP) facilitates uptake/oxidation of long-chain fatty acids in cultured transfected cells and primary hepatocytes, loss of L-FABP was expected to exacerbate weight gain and/or obesity in response to high dietary fat.	long-chain fatty acids	80-102	fatty acid binding protein 1, liver	Mus musculus	166-172
20357432-2	2010	Increased malonyl coenzyme A production which compromises oxidation of long-chain fatty acids via carnitine palmitoyltransferase (CPT) 1 inhibition plays a crucial role in the pathogenesis of these complications.	long-chain fatty acids	71-93	carnitine palmitoyltransferase 1A	Homo sapiens	98-136
20229815-1	2010	Fatty acid binding protein (FABP) is one of the intracellular proteins, with a low molecular weight of approximately 15 kDa, that plays important roles in the transportation and metabolism of long-chain fatty acids.	long-chain fatty acids	192-214	glutamic-oxaloacetic transaminase 2	Homo sapiens	0-26
20229815-1	2010	Fatty acid binding protein (FABP) is one of the intracellular proteins, with a low molecular weight of approximately 15 kDa, that plays important roles in the transportation and metabolism of long-chain fatty acids.	long-chain fatty acids	192-214	glutamic-oxaloacetic transaminase 2	Homo sapiens	28-32
20919650-5	2010	CerK is specific for natural ceramides with the erythro configuration in the base component and esterified to long-chain fatty acids.	long-chain fatty acids	110-132	ceramide kinase	Homo sapiens	0-4
20024786-1	2010	Acetyl-CoA carboxylase alpha (ACCalpha) is a major rate-limiting enzyme in the biogenesis of long-chain fatty acids.	long-chain fatty acids	93-115	acetyl-CoA carboxylase alpha	Gallus gallus	0-28
19700560-6	2009	Heterologous expression of CYP704B1 in yeast cells demonstrated that it catalyzes omega-hydroxylation of long-chain fatty acids, implicating these molecules in sporopollenin synthesis.	long-chain fatty acids	105-127	cytochrome P450, family 704, subfamily B, polypeptide 1	Arabidopsis thaliana	27-35
19758793-1	2010	BACKGROUND AND AIMS: GPR40 is a membrane-bound receptor paired with medium and long-chain fatty acids (FFA) as endogenous ligands.	long-chain fatty acids	79-101	free fatty acid receptor 1	Homo sapiens	21-26
19723916-2	2009	Fatty acid synthase (FAS) catalyzes the synthesis of long-chain fatty acids and is overexpressed in most human solid tumors.	long-chain fatty acids	53-75	fatty acid synthase	Homo sapiens	0-19
19723916-2	2009	Fatty acid synthase (FAS) catalyzes the synthesis of long-chain fatty acids and is overexpressed in most human solid tumors.	long-chain fatty acids	53-75	fatty acid synthase	Homo sapiens	21-24
19621081-4	2009	Feeding of C. elegans with [U-(13)C]-labelled E. coli revealed a decreased de novo synthesis of long-chain fatty acids in pept-1(lg601) and reduced levels of polyunsaturated fatty acids.	long-chain fatty acids	96-118	Peptide transporter family 1	Caenorhabditis elegans	122-128
19392830-1	2009	Acetyl-coenzyme A carboxylase alpha (ACACA) catalyses the first committed step in the biosynthesis of long-chain fatty acids (FA) by converting acetyl-CoA into malonyl-CoA.	long-chain fatty acids	102-124	acetyl-CoA carboxylase alpha	Sus scrofa	0-35
19392830-1	2009	Acetyl-coenzyme A carboxylase alpha (ACACA) catalyses the first committed step in the biosynthesis of long-chain fatty acids (FA) by converting acetyl-CoA into malonyl-CoA.	long-chain fatty acids	102-124	acetyl-CoA carboxylase alpha	Sus scrofa	37-42
19505953-1	2009	ELOVL6, a member of the elongation of very long-chain fatty acids (ELOVL) family, has recently been identified as the rate-limiting enzyme for the elongation of palmitoyl-CoA.	long-chain fatty acids	43-65	ELOVL family member 6, elongation of long chain fatty acids (yeast)	Mus musculus	0-6
19459852-2	2009	Acyl-CoA synthetase (ACS), which converts long-chain fatty acids to acyl-CoA, is overexpressed in various types of cancer.	long-chain fatty acids	42-64	acyl-CoA synthetase long-chain family member 1	Mus musculus	0-19
19459852-2	2009	Acyl-CoA synthetase (ACS), which converts long-chain fatty acids to acyl-CoA, is overexpressed in various types of cancer.	long-chain fatty acids	42-64	acyl-CoA synthetase long-chain family member 1	Mus musculus	21-24
19445909-6	2009	In addition, estradiol inhibited hypothalamic expression of carnitine palmitoyltransferase (CPT1a and CPT1c) and pyruvate dehydrogenase kinase 4 (PDK4), effects that would be expected to enhance the accumulation of long-chain fatty acids and glycolysis.	long-chain fatty acids	215-237	carnitine palmitoyltransferase 1a, liver	Mus musculus	92-97
19445909-6	2009	In addition, estradiol inhibited hypothalamic expression of carnitine palmitoyltransferase (CPT1a and CPT1c) and pyruvate dehydrogenase kinase 4 (PDK4), effects that would be expected to enhance the accumulation of long-chain fatty acids and glycolysis.	long-chain fatty acids	215-237	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	146-150
19517019-3	2009	Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids and is involved in both embryogenesis and cancer, has been recently proposed as a direct target of p53 family members, including p63 and p73.	long-chain fatty acids	58-80	fatty acid synthase	Homo sapiens	0-19
19553926-3	2009	Muscle carnitine palmitoyltransferase-1B (CPT1B) is a key enzyme in the regulation of skeletal muscle mitochondrial beta-oxidation of long-chain fatty acids, and as such is a reasonable biological candidate gene for skeletal muscle fat accumulation.	long-chain fatty acids	134-156	carnitine palmitoyltransferase 1B	Homo sapiens	42-47
19820339-3	2009	In a recent publication, we reported that the epidermal mis-expression of FATTY ACID ELONGASE1 (FAE1) in the Arabidopsis plant both increased the levels of very long-chain fatty acids in various lipid classes, and unexpectedly induced a cell-type specific cell death program in trichome cells, giving the plants a glabrous appearance.	long-chain fatty acids	161-183	3-ketoacyl-CoA synthase 18	Arabidopsis thaliana	74-94
19820339-3	2009	In a recent publication, we reported that the epidermal mis-expression of FATTY ACID ELONGASE1 (FAE1) in the Arabidopsis plant both increased the levels of very long-chain fatty acids in various lipid classes, and unexpectedly induced a cell-type specific cell death program in trichome cells, giving the plants a glabrous appearance.	long-chain fatty acids	161-183	3-ketoacyl-CoA synthase 18	Arabidopsis thaliana	96-100
19359527-2	2009	The elongase of long-chain fatty acids (ELOVL) family 6 (ELOVL6) is involved in the elongation of saturated and monosaturated fatty acids.	long-chain fatty acids	16-38	ELOVL fatty acid elongase 6	Homo sapiens	57-63
19517019-3	2009	Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids and is involved in both embryogenesis and cancer, has been recently proposed as a direct target of p53 family members, including p63 and p73.	long-chain fatty acids	58-80	fatty acid synthase	Homo sapiens	21-25
19517019-3	2009	Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids and is involved in both embryogenesis and cancer, has been recently proposed as a direct target of p53 family members, including p63 and p73.	long-chain fatty acids	58-80	tumor protein p53	Homo sapiens	180-183
19517019-3	2009	Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids and is involved in both embryogenesis and cancer, has been recently proposed as a direct target of p53 family members, including p63 and p73.	long-chain fatty acids	58-80	tumor protein p63	Homo sapiens	210-213
19517019-3	2009	Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids and is involved in both embryogenesis and cancer, has been recently proposed as a direct target of p53 family members, including p63 and p73.	long-chain fatty acids	58-80	tumor protein p73	Homo sapiens	218-221
19448714-3	2009	Extracellular long-chain fatty acids bind TLR2 and 4 and induce downstream signalling cascades implicated in cellular stress and inflammatory processes.	long-chain fatty acids	14-36	toll like receptor 2	Homo sapiens	42-52
19302064-1	2009	Liver mitochondrial beta-oxidation of LCFAs (long-chain fatty acids) is tightly regulated through inhibition of CPT1A (carnitine palmitoyltransferase 1A) by malonyl-CoA, an intermediate of lipogenesis stimulated by glucose and insulin.	long-chain fatty acids	45-67	carnitine palmitoyltransferase 1A	Rattus norvegicus	112-117
19302064-1	2009	Liver mitochondrial beta-oxidation of LCFAs (long-chain fatty acids) is tightly regulated through inhibition of CPT1A (carnitine palmitoyltransferase 1A) by malonyl-CoA, an intermediate of lipogenesis stimulated by glucose and insulin.	long-chain fatty acids	45-67	carnitine palmitoyltransferase 1A	Rattus norvegicus	119-152
19259639-2	2009	This review addresses the hypothesis that elongation of long-chain fatty acids family member 6 (Elovl6) has an important role in energy metabolism and insulin sensitivity.	long-chain fatty acids	56-78	ELOVL family member 6, elongation of long chain fatty acids (yeast)	Mus musculus	96-102
19208912-1	2009	OBJECTIVE: Intestinal L-cells secrete the incretin glucagon-like peptide-1 (GLP-1) in response to ingestion of nutrients, especially long-chain fatty acids.	long-chain fatty acids	133-155	glucagon	Rattus norvegicus	51-74
19208912-1	2009	OBJECTIVE: Intestinal L-cells secrete the incretin glucagon-like peptide-1 (GLP-1) in response to ingestion of nutrients, especially long-chain fatty acids.	long-chain fatty acids	133-155	glucagon	Rattus norvegicus	76-81
19505229-1	2009	Elongase of very-long-chain fatty acid (Elovl) 6 is a rate-limiting enzyme that is responsible for the elongation of long-chain fatty acids such as palmitoic acid (C16).	long-chain fatty acids	117-139	ELOVL family member 6, elongation of long chain fatty acids (yeast)	Mus musculus	40-48
19038945-0	2008	Short communication: elevated concentrations of oleic acid and long-chain fatty acids in milk fat of multiparous subclinical ketotic cows.	long-chain fatty acids	63-85	Weaning weight-maternal milk	Bos taurus	89-93
19254568-5	2009	A GAL4-dHNF4;UAS-lacZ ligand sensor can be activated by starvation or exogenous long-chain fatty acids, suggesting that dHNF4 is responsive to dietary signals.	long-chain fatty acids	80-102	Hepatocyte nuclear factor 4	Drosophila melanogaster	7-12
19254568-5	2009	A GAL4-dHNF4;UAS-lacZ ligand sensor can be activated by starvation or exogenous long-chain fatty acids, suggesting that dHNF4 is responsive to dietary signals.	long-chain fatty acids	80-102	Hepatocyte nuclear factor 4	Drosophila melanogaster	120-125
19112106-8	2009	These results, in conjunction with the findings that BmFATP stimulates the uptake of extracellular long-chain fatty acids and BmFATP knockdown reduces cellular long-chain acyl-CoA synthetase activity, suggest that BmFATP plays an essential role in bombykol biosynthesis by stimulating both LD accumulation and triacylglycerol synthesis via a process called vectorial acylation that couples the uptake of extracellular fatty acids with activation to CoA thioesters during pheromonogenesis.	long-chain fatty acids	99-121	fatty acid transport protein	Bombyx mori	53-59
19021548-6	2008	Interactive binding of zinc and long-chain fatty acids to albumin may therefore have physiological implications.	long-chain fatty acids	32-54	albumin	Homo sapiens	58-65
18706890-0	2008	Regulation of uncoupling protein 2 expression by long-chain fatty acids and hormones in bovine mammary epithelial cells.	long-chain fatty acids	49-71	uncoupling protein 2	Bos taurus	14-34
18761702-6	2008	Cotyledons of etiolated pd1 mutants have proplastids (compared with etioplasts in wt), less cuticular wax and fewer long-chain fatty acids.	long-chain fatty acids	116-138	prephenate dehydratase 1	Arabidopsis thaliana	24-27
18804373-0	2008	A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes.	long-chain fatty acids	16-38	furrow	Drosophila melanogaster	42-48
18718999-6	2008	Expression analysis showed less fatty acid transport protein 4 (FATP4) in intestinal scrapings of Npc1l1(-/-) and ezetimibe-treated mice, suggesting an important role for FATP4 in intestinal absorption of long-chain fatty acids.	long-chain fatty acids	205-227	solute carrier family 27 (fatty acid transporter), member 4	Mus musculus	32-62
18718999-6	2008	Expression analysis showed less fatty acid transport protein 4 (FATP4) in intestinal scrapings of Npc1l1(-/-) and ezetimibe-treated mice, suggesting an important role for FATP4 in intestinal absorption of long-chain fatty acids.	long-chain fatty acids	205-227	solute carrier family 27 (fatty acid transporter), member 4	Mus musculus	64-69
18718999-6	2008	Expression analysis showed less fatty acid transport protein 4 (FATP4) in intestinal scrapings of Npc1l1(-/-) and ezetimibe-treated mice, suggesting an important role for FATP4 in intestinal absorption of long-chain fatty acids.	long-chain fatty acids	205-227	solute carrier family 27 (fatty acid transporter), member 4	Mus musculus	171-176
18652860-1	2008	The mitochondrial trifunctional protein (MTP) is a heterotrimeric protein that consists of four alpha-subunits and four beta-subunits and catalyzes three of the four chain-shortening reactions in the mitochondrial beta-oxidation of long-chain fatty acids.	long-chain fatty acids	232-254	microsomal triglyceride transfer protein	Homo sapiens	4-39
18652860-1	2008	The mitochondrial trifunctional protein (MTP) is a heterotrimeric protein that consists of four alpha-subunits and four beta-subunits and catalyzes three of the four chain-shortening reactions in the mitochondrial beta-oxidation of long-chain fatty acids.	long-chain fatty acids	232-254	microsomal triglyceride transfer protein	Homo sapiens	41-44
18793157-8	2008	Long-chain fatty acids are proposed as natural PPAR ligands and some specific endogenous pathways of lipid metabolism are believed to generate PPAR agonists.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Homo sapiens	47-51
18793157-8	2008	Long-chain fatty acids are proposed as natural PPAR ligands and some specific endogenous pathways of lipid metabolism are believed to generate PPAR agonists.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Homo sapiens	143-147
18793167-1	2008	GPR40 (G-protein-coupled receptor 40) has been shown to be a physiologically relevant receptor for long-chain fatty acids.	long-chain fatty acids	99-121	free fatty acid receptor 1	Mus musculus	0-5
18793167-1	2008	GPR40 (G-protein-coupled receptor 40) has been shown to be a physiologically relevant receptor for long-chain fatty acids.	long-chain fatty acids	99-121	free fatty acid receptor 1	Mus musculus	7-36
19012600-1	2008	Fatty acids translocase (FAT) is a transporter that facilitate long-chain fatty acids uptake as well as lipid accretion.	long-chain fatty acids	63-85	CD36 molecule	Homo sapiens	0-23
19012600-1	2008	Fatty acids translocase (FAT) is a transporter that facilitate long-chain fatty acids uptake as well as lipid accretion.	long-chain fatty acids	63-85	CD36 molecule	Homo sapiens	25-28
18804373-5	2008	Here, we show that mutations in the gene bond, which encodes a Drosophila member of the family of Elovl proteins that mediate elongation of very-long-chain fatty acids, block or dramatically slow cleavage-furrow ingression during early telophase in dividing spermatocytes.	long-chain fatty acids	145-167	furrow	Drosophila melanogaster	205-211
18635971-1	2008	Fatty Acid Synthase (FASN), a cytoplasmic biosynthetic enzyme, is the major source of long-chain fatty acids, particularly palmitate.	long-chain fatty acids	86-108	fatty acid synthase	Homo sapiens	0-19
18723500-1	2008	Expression of fatty acid synthase (FASN), the key enzyme in de novo synthesis of long-chain fatty acids, is normally low but increases in cancer.	long-chain fatty acids	81-103	fatty acid synthase	Homo sapiens	14-33
18723500-1	2008	Expression of fatty acid synthase (FASN), the key enzyme in de novo synthesis of long-chain fatty acids, is normally low but increases in cancer.	long-chain fatty acids	81-103	fatty acid synthase	Homo sapiens	35-39
18559658-1	2008	OBJECTIVE: The G-protein-coupled receptor GPR40 is expressed in pancreatic beta-cells and is activated by long-chain fatty acids.	long-chain fatty acids	106-128	free fatty acid receptor 1	Mus musculus	42-47
18635971-1	2008	Fatty Acid Synthase (FASN), a cytoplasmic biosynthetic enzyme, is the major source of long-chain fatty acids, particularly palmitate.	long-chain fatty acids	86-108	fatty acid synthase	Homo sapiens	21-25
18521119-4	2008	To identify the product of the whd gene we used a sequence-based positional candidate approach and by this method we determined that whd encodes carnitine palmitoyltransferase I (CPT I), an enzyme of the outer mitochondrial membrane that is required for the import of long-chain fatty acids into the mitochondria for beta-oxidation.	long-chain fatty acids	268-290	withered	Drosophila melanogaster	145-177
18481958-2	2008	GPR40 functions as a receptor for medium and long-chain fatty acids, and has been implicated in mediating both physiological and pathological effects of fatty acids on beta-cells.	long-chain fatty acids	45-67	free fatty acid receptor 1	Homo sapiens	0-5
18362158-1	2008	Bovine serum albumin (BSA) and fatty acid-free human serum albumin (HSAFAF) reduce the K(m) values for UGT2B7 substrates by sequestering inhibitory long-chain fatty acids released by incubations of human liver microsomes (HLM) and HEK293 cells expressing this enzyme.	long-chain fatty acids	148-170	albumin	Homo sapiens	7-20
18362158-1	2008	Bovine serum albumin (BSA) and fatty acid-free human serum albumin (HSAFAF) reduce the K(m) values for UGT2B7 substrates by sequestering inhibitory long-chain fatty acids released by incubations of human liver microsomes (HLM) and HEK293 cells expressing this enzyme.	long-chain fatty acids	148-170	albumin	Homo sapiens	53-66
18440731-1	2008	The human fatty acid binding protein (FABP2) is involved in intestinal absorption and intracellular trafficking of long-chain fatty acids.	long-chain fatty acids	115-137	glutamic-oxaloacetic transaminase 2	Homo sapiens	10-36
18440731-1	2008	The human fatty acid binding protein (FABP2) is involved in intestinal absorption and intracellular trafficking of long-chain fatty acids.	long-chain fatty acids	115-137	fatty acid binding protein 2	Homo sapiens	38-43
18520060-1	2008	The tissue distribution and disposition of carnitine, which plays an important role in the transport of long-chain fatty acids across the mitochondrial inner membrane for beta-oxidation, are well controlled by carnitine transporter organic cation/carnitine transporter 2 (OCTN2).	long-chain fatty acids	104-126	solute carrier family 22 member 5	Rattus norvegicus	232-270
18520060-1	2008	The tissue distribution and disposition of carnitine, which plays an important role in the transport of long-chain fatty acids across the mitochondrial inner membrane for beta-oxidation, are well controlled by carnitine transporter organic cation/carnitine transporter 2 (OCTN2).	long-chain fatty acids	104-126	solute carrier family 22 member 5	Rattus norvegicus	272-277
18362158-1	2008	Bovine serum albumin (BSA) and fatty acid-free human serum albumin (HSAFAF) reduce the K(m) values for UGT2B7 substrates by sequestering inhibitory long-chain fatty acids released by incubations of human liver microsomes (HLM) and HEK293 cells expressing this enzyme.	long-chain fatty acids	148-170	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	103-109
18521119-4	2008	To identify the product of the whd gene we used a sequence-based positional candidate approach and by this method we determined that whd encodes carnitine palmitoyltransferase I (CPT I), an enzyme of the outer mitochondrial membrane that is required for the import of long-chain fatty acids into the mitochondria for beta-oxidation.	long-chain fatty acids	268-290	withered	Drosophila melanogaster	179-184
18279394-0	2008	Suppressed catalytic efficiency of plasmin in the presence of long-chain fatty acids.	long-chain fatty acids	62-84	plasminogen	Homo sapiens	35-42
18226296-1	2008	The solute carrier family 27 member 1 (SLC27A1) is an integral membrane protein involved in the transport of long-chain fatty acids across the plasma membrane.	long-chain fatty acids	109-131	solute carrier family 27 member 1	Bos taurus	4-37
18226296-1	2008	The solute carrier family 27 member 1 (SLC27A1) is an integral membrane protein involved in the transport of long-chain fatty acids across the plasma membrane.	long-chain fatty acids	109-131	solute carrier family 27 member 1	Bos taurus	39-46
18272525-1	2008	Yeast Phs1 is the 3-hydroxyacyl-CoA dehydratase that catalyzes the third reaction of the four-step cycle in the elongation of very long-chain fatty acids (VLCFAs).	long-chain fatty acids	131-153	enoyl-CoA hydratase PHS1	Saccharomyces cerevisiae S288C	6-10
18281277-1	2008	Here we report that in skeletal muscle cells the contribution to insulin resistance and inflammation of two common dietary long-chain fatty acids depends on the channeling of these lipids to distinct cellular metabolic fates.	long-chain fatty acids	123-145	insulin	Homo sapiens	65-72
18262487-1	2008	The rat hepatic gene CYP4F1 encodes a fatty acid omega hydroxylase P450 that metabolizes proinflammatory eicosanoids and long-chain fatty acids.	long-chain fatty acids	121-143	cytochrome P450, family 4, subfamily f, polypeptide 1	Rattus norvegicus	21-27
18172011-8	2008	Our studies also suggested that cycloxygenase 2-derived metabolites of long-chain fatty acids function as endogenous activating ligands of PPARgamma in the preovulatory follicles.	long-chain fatty acids	71-93	peroxisome proliferator activated receptor gamma	Mus musculus	139-148
17905618-6	2008	Conversely, the Ki for fluvastatin and norfloxacin were in the order of 10(-7) and 10(-6)M, similar to the affinity for BLG by natural ligands, such as retinoids and long-chain fatty acids.	long-chain fatty acids	166-188	beta-lactoglobulin	Bos taurus	120-123
18326828-4	2008	The acyl-coA elongase complex synthesizes very-long-chain fatty acids (VLCFAs), and the accumulation of extracellular VLCFA-derived metabolites (leaf epidermal wax components) was affected in MYB30 knockout mutant and overexpressing lines.	long-chain fatty acids	47-69	myb domain protein 30	Arabidopsis thaliana	192-197
18407910-9	2008	A so-called structured lipid composed of the medium-chain fatty acid dodecanoic acid on the 2 position and long-chain fatty acids on the 1 and 3 positions appeared to be endogenously synthesized in response to the LCT/2mono diet.	long-chain fatty acids	107-129	lactase	Rattus norvegicus	214-217
17950700-1	2007	Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the synthesis of cholesteryl esters from cholesterol and long-chain fatty acids.	long-chain fatty acids	118-140	carboxylesterase 1	Homo sapiens	0-43
17936861-0	2008	Peptide YY levels are associated with appetite suppression in response to long-chain fatty acids.	long-chain fatty acids	74-96	peptide YY	Homo sapiens	0-10
18154422-5	2008	RESULTS: Long-chain fatty acids significantly increased the abundance of PPAR and PPAR.	long-chain fatty acids	9-31	peroxisome proliferator activated receptor alpha	Mus musculus	73-77
18154422-5	2008	RESULTS: Long-chain fatty acids significantly increased the abundance of PPAR and PPAR.	long-chain fatty acids	9-31	peroxisome proliferator activated receptor alpha	Mus musculus	82-86
17950700-1	2007	Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the synthesis of cholesteryl esters from cholesterol and long-chain fatty acids.	long-chain fatty acids	118-140	carboxylesterase 1	Homo sapiens	45-49
17011156-3	2007	In this study, we determined effects of SCFA and long-chain fatty acids (LCFA) on leptin expression in bovine adipocytes.	long-chain fatty acids	49-71	leptin	Bos taurus	82-88
17827874-2	2007	In a previous study, we showed that the genes for elongation of long-chain fatty acids family member 5 (ELOVL5) and stearoyl-CoA desaturase 1 (SCD1) increased their expression significantly, concomitant with induction of pheromone synthesis.	long-chain fatty acids	64-86	elongation of very long chain fatty acids protein 5	Capra hircus	104-110
17827874-2	2007	In a previous study, we showed that the genes for elongation of long-chain fatty acids family member 5 (ELOVL5) and stearoyl-CoA desaturase 1 (SCD1) increased their expression significantly, concomitant with induction of pheromone synthesis.	long-chain fatty acids	64-86	stearoyl-CoA desaturase	Capra hircus	116-141
17827874-2	2007	In a previous study, we showed that the genes for elongation of long-chain fatty acids family member 5 (ELOVL5) and stearoyl-CoA desaturase 1 (SCD1) increased their expression significantly, concomitant with induction of pheromone synthesis.	long-chain fatty acids	64-86	stearoyl-CoA desaturase	Capra hircus	143-147
17620421-11	2007	Ceramides or their metabolites could contribute to adverse effects of long-chain fatty acids on insulin resistance and inflammation.	long-chain fatty acids	70-92	insulin	Homo sapiens	96-103
18253084-1	2007	Carnitine palmitoyl transferase I (CPT1) catalyzes the transport of long-chain fatty acids into mitochondria for beta-oxidation.	long-chain fatty acids	68-90	carnitine palmitoyltransferase 1A	Homo sapiens	35-39
17508264-1	2007	Carnitine-acylcarnitine translocase (CACT) deficiency is a rare disorder that results in long-chain fatty acids being unavailable for mitochondrial beta-oxidation and ketogenesis.	long-chain fatty acids	89-111	solute carrier family 25 member 20	Homo sapiens	0-35
17508264-1	2007	Carnitine-acylcarnitine translocase (CACT) deficiency is a rare disorder that results in long-chain fatty acids being unavailable for mitochondrial beta-oxidation and ketogenesis.	long-chain fatty acids	89-111	solute carrier family 25 member 20	Homo sapiens	37-41
17514507-1	2007	Very long-chain acyl-CoA dehydrogenase (VLCAD) catalyses the initial step of mitochondrial beta-oxidation of long-chain fatty acids with a chain length of 14 to 20 carbons.	long-chain fatty acids	109-131	acyl-CoA dehydrogenase very long chain	Homo sapiens	0-38
17514507-1	2007	Very long-chain acyl-CoA dehydrogenase (VLCAD) catalyses the initial step of mitochondrial beta-oxidation of long-chain fatty acids with a chain length of 14 to 20 carbons.	long-chain fatty acids	109-131	acyl-CoA dehydrogenase very long chain	Homo sapiens	40-45
17530838-1	2007	Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids.	long-chain fatty acids	129-151	stearoyl-CoA desaturase	Homo sapiens	0-25
17478525-1	2007	The transport of long-chain fatty acids (LCFAs) across mitochondrial membranes is regulated by carnitine palmitoyltransferase I (CPTI) activity.	long-chain fatty acids	17-39	carnitine palmitoyltransferase 1B	Rattus norvegicus	95-127
17478525-1	2007	The transport of long-chain fatty acids (LCFAs) across mitochondrial membranes is regulated by carnitine palmitoyltransferase I (CPTI) activity.	long-chain fatty acids	17-39	carnitine palmitoyltransferase 1B	Rattus norvegicus	129-133
17583696-1	2007	Elongation of very long-chain fatty acids (ELOVL) members were overexpressed in two preadipocyte cell lines, ELOVL2 and ELOVL3 in 3T3-L1 cells, and ELOVL1-3 in F442A cells.	long-chain fatty acids	19-41	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	Mus musculus	109-115
17583696-1	2007	Elongation of very long-chain fatty acids (ELOVL) members were overexpressed in two preadipocyte cell lines, ELOVL2 and ELOVL3 in 3T3-L1 cells, and ELOVL1-3 in F442A cells.	long-chain fatty acids	19-41	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	120-126
17530838-1	2007	Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids.	long-chain fatty acids	129-151	stearoyl-CoA desaturase	Homo sapiens	27-31
16645727-1	2007	Fatty acid translocase (FAT)/CD36 is a multi-functional membrane protein participating in uptake of long-chain fatty acids and oxidized low density lipoprotein, playing an important role in lipid homeostasis.	long-chain fatty acids	100-122	CD36 molecule	Homo sapiens	0-22
16645727-1	2007	Fatty acid translocase (FAT)/CD36 is a multi-functional membrane protein participating in uptake of long-chain fatty acids and oxidized low density lipoprotein, playing an important role in lipid homeostasis.	long-chain fatty acids	100-122	CD36 molecule	Homo sapiens	24-27
17445541-2	2007	The carnitine palmitoyltransferase (CPT) enzyme system facilitates the transport of long-chain fatty acids into mitochondria, and the gene for the hepatic isoform of CPT1 (CPT1A) is a candidate gene for metabolic disorders such as insulin resistance associated with fatty liver.	long-chain fatty acids	84-106	carnitine palmitoyltransferase 1A	Homo sapiens	166-170
17445541-2	2007	The carnitine palmitoyltransferase (CPT) enzyme system facilitates the transport of long-chain fatty acids into mitochondria, and the gene for the hepatic isoform of CPT1 (CPT1A) is a candidate gene for metabolic disorders such as insulin resistance associated with fatty liver.	long-chain fatty acids	84-106	carnitine palmitoyltransferase 1A	Homo sapiens	172-177
17445541-2	2007	The carnitine palmitoyltransferase (CPT) enzyme system facilitates the transport of long-chain fatty acids into mitochondria, and the gene for the hepatic isoform of CPT1 (CPT1A) is a candidate gene for metabolic disorders such as insulin resistance associated with fatty liver.	long-chain fatty acids	84-106	insulin	Homo sapiens	231-238
17134953-4	2007	PPARalpha is a transcriptional factor that regulates gene expression when activated by endogenous or exogenous long-chain fatty acids.	long-chain fatty acids	111-133	peroxisome proliferator activated receptor alpha	Homo sapiens	0-9
17242157-4	2007	It is shown that despite apparently different physiological functions, hUCP2 exhibited its protonophoric function similar to hUCP1--exclusively in the presence of long-chain fatty acids (FA).	long-chain fatty acids	163-185	uncoupling protein 2	Homo sapiens	71-76
17343826-1	2007	The cytosolic human intestinal fatty acid binding protein (hFABP2) is proposed to be involved in intestinal absorption of long-chain fatty acids.	long-chain fatty acids	122-144	fatty acid binding protein 2	Homo sapiens	59-65
17236726-3	2007	Phylogenetic analysis of the deduced amino acid sequence suggests that HpELO1 is an ortholog of the Saccharomyces cerevisiae ELO3 gene that is involved in the elongation of very long-chain fatty acids (VLCFAs).	long-chain fatty acids	178-200	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	125-129
17092750-2	2007	Mutations in ALDP result in elevated levels of very long-chain fatty acids (VLCFA) and reduced VLCFA beta-oxidation in peroxisomes.	long-chain fatty acids	52-74	ATP binding cassette subfamily D member 1	Homo sapiens	13-17
17250804-1	2007	Recently, it has been found that long-chain fatty acids activate the G protein-coupled receptors (GPRs), GPR120 and GPR40.	long-chain fatty acids	33-55	free fatty acid receptor 4	Homo sapiens	105-111
17250804-1	2007	Recently, it has been found that long-chain fatty acids activate the G protein-coupled receptors (GPRs), GPR120 and GPR40.	long-chain fatty acids	33-55	free fatty acid receptor 1	Homo sapiens	116-121
17208947-0	2007	Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.	long-chain fatty acids	40-62	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	19-25
17208947-8	2007	Lipid analyses of epidermis from Elovl4(del/del) mice revealed a global decrease in very long-chain fatty acids (VLFAs) (i.e., carbon chain > or =C28) in both the ceramide/glucosylceramide and the free fatty-acid fractions.	long-chain fatty acids	89-111	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	33-39
17311939-4	2007	Although dietary fats have been shown to modulate the expression of genes involved in both lipid and carbohydrate metabolism in liver, little is known regarding the molecular mechanism of transcriptional response of the Glc-6-Pase gene to long-chain fatty acids.	long-chain fatty acids	239-261	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	220-230
17201745-4	2007	Long-chain fatty acids activate peroxisome proliferator-activated receptors (PPAR), thus mRNA levels of PPAR target genes were measured.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	32-75
17201745-4	2007	Long-chain fatty acids activate peroxisome proliferator-activated receptors (PPAR), thus mRNA levels of PPAR target genes were measured.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	77-81
17201745-4	2007	Long-chain fatty acids activate peroxisome proliferator-activated receptors (PPAR), thus mRNA levels of PPAR target genes were measured.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	104-108
16949688-5	2006	ALDP defects lead to characteristic accumulation of saturated very long-chain fatty acids, the diagnostic disease marker.	long-chain fatty acids	67-89	ATP binding cassette subfamily D member 1	Homo sapiens	0-4
17007889-2	2006	Long-chain fatty acids have been shown to induce expression of the genes related to fatty acid metabolism through PPARalpha.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Homo sapiens	114-123
17168665-1	2006	The expression and activity of Fatty Acid Synthase (FASN; the sole enzyme capable of the reductive de novo synthesis of long-chain fatty acids from acetyl-CoA, malonyl-CoA, and nicotinamide adenine dinucleotide phosphate -NADPH-) is extremely low in nearly all nonmalignant adult tissues, whereas it is significantly up-regulated or activated in many cancer types, thus creating the potential for a large therapeutic index.	long-chain fatty acids	120-142	fatty acid synthase	Homo sapiens	52-56
17130495-1	2006	The secretagogue, the incretin-like, and the suppressive activities of long-chain fatty acids (LCFAs) in modulating insulin secretion in vivo and in cultured islets were simulated here by beta,beta"-tetramethyl-hexadecanedioic acid (M16) and alpha,alpha"-tetrachloro-tetradecanedioic acid (Cl-DICA).	long-chain fatty acids	71-93	insulin	Homo sapiens	116-123
16640656-2	2006	(J Immunol 2000;165:3584-91) that the maturation of dendritic cells (DC) in the presence of long-chain fatty acids redirects DC into Th0/Th2-inducing cells suggesting the involvement of a receptor for long-chain fatty acids like members of the peroxisome proliferator-activated receptors (PPAR) superfamily.	long-chain fatty acids	92-114	peroxisome proliferator activated receptor alpha	Homo sapiens	244-287
16920127-2	2006	In this procedure, long-chain fatty acids (C(14), C(16) and C(18)) were converted into their ion-pair complexes with tetrabutylammonium hydrogen sulfate and then extracted by organic solvent (1-octanol) impregnated in the hollow fiber.	long-chain fatty acids	19-41	Bardet-Biedl syndrome 9	Homo sapiens	60-65
17052194-6	2006	GPR40, activated by medium and long-chain fatty acids, has been shown to potentiate insulin secretion at the beta-cell, and has been hypothesized to participate in the detrimental effects of chronic fatty acid exposure on beta-cell function.	long-chain fatty acids	31-53	free fatty acid receptor 1	Homo sapiens	0-5
17052194-6	2006	GPR40, activated by medium and long-chain fatty acids, has been shown to potentiate insulin secretion at the beta-cell, and has been hypothesized to participate in the detrimental effects of chronic fatty acid exposure on beta-cell function.	long-chain fatty acids	31-53	insulin	Homo sapiens	84-91
16980563-14	2006	These data indicate that CER4 is an alcohol-forming FAR that has specificity for very-long-chain fatty acids and is responsible for the synthesis of primary alcohols in the epidermal cells of aerial tissues and in roots.	long-chain fatty acids	86-108	Jojoba acyl CoA reductase-related male sterility protein	Arabidopsis thaliana	25-29
16777940-1	2006	Long-chain fatty acids acyl coenzyme A esters (LC-CoA) are obligate intermediates of fatty acid metabolism and have been shown to activate K(ATP) channels but to inhibit most other Kir channels (e.g. Kir2.1) by direct channel binding.	long-chain fatty acids	0-22	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	181-184
16777940-1	2006	Long-chain fatty acids acyl coenzyme A esters (LC-CoA) are obligate intermediates of fatty acid metabolism and have been shown to activate K(ATP) channels but to inhibit most other Kir channels (e.g. Kir2.1) by direct channel binding.	long-chain fatty acids	0-22	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	200-206
16834775-3	2006	RESULTS: Acyl-CoA Synthetase Long-chain member 6 (ACSL6) is responsible for activation of long-chain fatty acids in erythrocytes.	long-chain fatty acids	90-112	acyl-CoA synthetase long chain family member 6	Homo sapiens	9-48
16834775-3	2006	RESULTS: Acyl-CoA Synthetase Long-chain member 6 (ACSL6) is responsible for activation of long-chain fatty acids in erythrocytes.	long-chain fatty acids	90-112	acyl-CoA synthetase long chain family member 6	Homo sapiens	50-55
16611988-1	2006	Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues.	long-chain fatty acids	115-137	solute carrier family 27 member 1	Homo sapiens	0-30
16611988-1	2006	Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues.	long-chain fatty acids	115-137	solute carrier family 27 member 1	Homo sapiens	32-37
16611988-1	2006	Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues.	long-chain fatty acids	115-137	solute carrier family 27 member 1	Homo sapiens	32-36
16611988-1	2006	Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues.	long-chain fatty acids	115-137	insulin	Homo sapiens	174-181
17168665-1	2006	The expression and activity of Fatty Acid Synthase (FASN; the sole enzyme capable of the reductive de novo synthesis of long-chain fatty acids from acetyl-CoA, malonyl-CoA, and nicotinamide adenine dinucleotide phosphate -NADPH-) is extremely low in nearly all nonmalignant adult tissues, whereas it is significantly up-regulated or activated in many cancer types, thus creating the potential for a large therapeutic index.	long-chain fatty acids	120-142	fatty acid synthase	Homo sapiens	31-50
17012783-2	2006	ACBP is a carrier for activated long-chain fatty acids and has been associated with many aspects of lipid metabolism.	long-chain fatty acids	32-54	diazepam binding inhibitor, acyl-CoA binding protein	Bos taurus	0-4
16781677-1	2006	Carnitine palmitoyltransferase II (CPT-II) has a crucial role in the beta-oxidation of long-chain fatty acids in mitochondria.	long-chain fatty acids	87-109	carnitine palmitoyltransferase 2	Rattus norvegicus	0-33
16781677-1	2006	Carnitine palmitoyltransferase II (CPT-II) has a crucial role in the beta-oxidation of long-chain fatty acids in mitochondria.	long-chain fatty acids	87-109	carnitine palmitoyltransferase 2	Rattus norvegicus	35-41
16880373-1	2006	Very long-chain acyl-CoA dehydrogenase deficiency (VLCAD) is a key enzyme catalysing the dehydrogenation of long-chain fatty acids in mitochondrial beta-oxidation.	long-chain fatty acids	108-130	acyl-CoA dehydrogenase very long chain	Homo sapiens	51-56
17021367-2	2006	Fatty acid synthase (FAS) catalyzes the synthesis of long-chain fatty acids, whereas the breakdown of fatty acids by beta-oxidation is regulated by carnitine palmitoyltransferase-1, the rate-limiting enzyme for the entry of fatty acids into the mitochondria for oxidation.	long-chain fatty acids	53-75	fatty acid synthase	Homo sapiens	0-19
17021367-2	2006	Fatty acid synthase (FAS) catalyzes the synthesis of long-chain fatty acids, whereas the breakdown of fatty acids by beta-oxidation is regulated by carnitine palmitoyltransferase-1, the rate-limiting enzyme for the entry of fatty acids into the mitochondria for oxidation.	long-chain fatty acids	53-75	fatty acid synthase	Homo sapiens	21-24
16753600-1	2006	Fatty acid synthase is an enzyme that catalyzes the synthesis of long-chain fatty acids.	long-chain fatty acids	65-87	fatty acid synthase	Homo sapiens	0-19
16882015-2	2006	B-FABP exhibits a binding affinity to long-chain fatty acids (FAs) whose effects on brain functions including development, emotion, learning and memory have been proposed.	long-chain fatty acids	38-60	fatty acid binding protein 7, brain	Mus musculus	0-6
16981429-0	2006	The inhibitory action of long-chain fatty acids on the DNA binding activity of p53.	long-chain fatty acids	25-47	tumor protein p53	Homo sapiens	79-82
16406390-0	2006	Wettability of calcite and mica modified by different long-chain fatty acids (C18 acids).	long-chain fatty acids	54-76	MHC class I polypeptide-related sequence A	Homo sapiens	27-31
16406390-0	2006	Wettability of calcite and mica modified by different long-chain fatty acids (C18 acids).	long-chain fatty acids	54-76	Bardet-Biedl syndrome 9	Homo sapiens	78-81
16640656-2	2006	(J Immunol 2000;165:3584-91) that the maturation of dendritic cells (DC) in the presence of long-chain fatty acids redirects DC into Th0/Th2-inducing cells suggesting the involvement of a receptor for long-chain fatty acids like members of the peroxisome proliferator-activated receptors (PPAR) superfamily.	long-chain fatty acids	92-114	peroxisome proliferator activated receptor alpha	Homo sapiens	289-293
16640656-2	2006	(J Immunol 2000;165:3584-91) that the maturation of dendritic cells (DC) in the presence of long-chain fatty acids redirects DC into Th0/Th2-inducing cells suggesting the involvement of a receptor for long-chain fatty acids like members of the peroxisome proliferator-activated receptors (PPAR) superfamily.	long-chain fatty acids	201-223	peroxisome proliferator activated receptor alpha	Homo sapiens	244-287
16640656-2	2006	(J Immunol 2000;165:3584-91) that the maturation of dendritic cells (DC) in the presence of long-chain fatty acids redirects DC into Th0/Th2-inducing cells suggesting the involvement of a receptor for long-chain fatty acids like members of the peroxisome proliferator-activated receptors (PPAR) superfamily.	long-chain fatty acids	201-223	peroxisome proliferator activated receptor alpha	Homo sapiens	289-293
16449229-6	2006	Elo2p and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both Elo2p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular functions.	long-chain fatty acids	55-77	fatty acid elongase ELO2	Saccharomyces cerevisiae S288C	0-5
16449229-6	2006	Elo2p and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both Elo2p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular functions.	long-chain fatty acids	55-77	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	10-15
16449229-6	2006	Elo2p and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both Elo2p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular functions.	long-chain fatty acids	158-180	fatty acid elongase ELO2	Saccharomyces cerevisiae S288C	0-5
16449229-6	2006	Elo2p and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both Elo2p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular functions.	long-chain fatty acids	158-180	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	10-15
16449229-6	2006	Elo2p and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both Elo2p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular functions.	long-chain fatty acids	158-180	fatty acid elongase ELO2	Saccharomyces cerevisiae S288C	104-109
16449229-6	2006	Elo2p and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both Elo2p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular functions.	long-chain fatty acids	158-180	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	114-119
16469493-2	2006	Gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) is a novel hormonally regulated fatty acyl-CoA synthetase (FACS) with activity for long-chain fatty acids.	long-chain fatty acids	147-169	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	0-53
16219667-1	2006	Fatty acid translocase (FAT/CD36) is a transport protein with a high affinity for long-chain fatty acids (LCFA).	long-chain fatty acids	82-104	CD36 molecule	Homo sapiens	0-22
16219667-1	2006	Fatty acid translocase (FAT/CD36) is a transport protein with a high affinity for long-chain fatty acids (LCFA).	long-chain fatty acids	82-104	CD36 molecule	Homo sapiens	24-27
16423905-1	2006	BACKGROUND: The human mitochondrial trifunctional protein (MTP) complex is composed of 4 hydroacyl-CoA dehydrogenase-alpha (HADHA) and 4 hydroacyl-CoA dehydrogenase-beta (HADHB) subunits, which catalyze the last 3 steps in the fatty acid beta-oxidation spiral of long-chain fatty acids.	long-chain fatty acids	263-285	microsomal triglyceride transfer protein	Homo sapiens	22-57
16423905-1	2006	BACKGROUND: The human mitochondrial trifunctional protein (MTP) complex is composed of 4 hydroacyl-CoA dehydrogenase-alpha (HADHA) and 4 hydroacyl-CoA dehydrogenase-beta (HADHB) subunits, which catalyze the last 3 steps in the fatty acid beta-oxidation spiral of long-chain fatty acids.	long-chain fatty acids	263-285	microsomal triglyceride transfer protein	Homo sapiens	59-62
16423905-1	2006	BACKGROUND: The human mitochondrial trifunctional protein (MTP) complex is composed of 4 hydroacyl-CoA dehydrogenase-alpha (HADHA) and 4 hydroacyl-CoA dehydrogenase-beta (HADHB) subunits, which catalyze the last 3 steps in the fatty acid beta-oxidation spiral of long-chain fatty acids.	long-chain fatty acids	263-285	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	124-129
16423905-1	2006	BACKGROUND: The human mitochondrial trifunctional protein (MTP) complex is composed of 4 hydroacyl-CoA dehydrogenase-alpha (HADHA) and 4 hydroacyl-CoA dehydrogenase-beta (HADHB) subunits, which catalyze the last 3 steps in the fatty acid beta-oxidation spiral of long-chain fatty acids.	long-chain fatty acids	263-285	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	Homo sapiens	171-176
16615913-1	2006	Carnitine palmitoyltransferases 1 and 2 (CPTs) facilitate the import of long-chain fatty acids into mitochondria.	long-chain fatty acids	72-94	carnitine palmitoyltransferase 2	Homo sapiens	0-39
16262600-3	2006	More recent observations, notably on L-FABP-deficient mice, indicated a possible direct involvement of L-FABP in the peroxisomal oxidation of long-chain fatty acids.	long-chain fatty acids	142-164	fatty acid binding protein 1, liver	Mus musculus	37-43
16262600-3	2006	More recent observations, notably on L-FABP-deficient mice, indicated a possible direct involvement of L-FABP in the peroxisomal oxidation of long-chain fatty acids.	long-chain fatty acids	142-164	fatty acid binding protein 1, liver	Mus musculus	103-109
16469493-2	2006	Gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) is a novel hormonally regulated fatty acyl-CoA synthetase (FACS) with activity for long-chain fatty acids.	long-chain fatty acids	147-169	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	55-62
16499569-1	2006	Clonorchis sinensis, the Chinese liver fluke, resides chronically in the biliary tract, and fatty acid-binding protein (FABP) is known to play an important role in the intracellular transport of long-chain fatty acids obtained from the host.	long-chain fatty acids	195-217	fatty acid binding protein 2	Rattus norvegicus	120-124
16304351-1	2006	The purpose of this study was to investigate the effects of long-chain fatty acids (LCFAs) on AMP-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC) phosphorylation and beta-oxidation in skeletal muscle.	long-chain fatty acids	60-82	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	94-122
16304351-1	2006	The purpose of this study was to investigate the effects of long-chain fatty acids (LCFAs) on AMP-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC) phosphorylation and beta-oxidation in skeletal muscle.	long-chain fatty acids	60-82	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	124-128
16249179-1	2005	Mammalian isoforms of acetyl-CoA carboxylase (ACC-1 and ACC-2) play important roles in synthesis, elongation, and oxidation of long-chain fatty acids, and the possible significance of ACC in the development of obesity has led to interest in the development of inhibitors.	long-chain fatty acids	127-149	acetyl-CoA carboxylase alpha	Rattus norvegicus	46-51
16601878-1	2006	Infantile neuronal ceroid lipofuscinosis (INCL, also known as infantile Batten disease) is a devastating neurodegenerative disorder caused by deficiency in the lysosomal enzyme palmitoyl-protein thioesterase (PPT, or CLN1), which functions to remove long-chain fatty acids from cysteine residues in proteins.	long-chain fatty acids	250-272	palmitoyl-protein thioesterase 1	Homo sapiens	177-207
16601878-1	2006	Infantile neuronal ceroid lipofuscinosis (INCL, also known as infantile Batten disease) is a devastating neurodegenerative disorder caused by deficiency in the lysosomal enzyme palmitoyl-protein thioesterase (PPT, or CLN1), which functions to remove long-chain fatty acids from cysteine residues in proteins.	long-chain fatty acids	250-272	palmitoyl-protein thioesterase 1	Homo sapiens	209-212
16529296-1	2006	The intestinal fatty acid-binding protein (I-FABP) shows binding specificity for long-chain fatty acids and is proposed to be involved in the uptake of dietary fatty acids and their intracellular transport.	long-chain fatty acids	81-103	fatty acid binding protein 2	Sus scrofa	4-41
16529296-1	2006	The intestinal fatty acid-binding protein (I-FABP) shows binding specificity for long-chain fatty acids and is proposed to be involved in the uptake of dietary fatty acids and their intracellular transport.	long-chain fatty acids	81-103	fatty acid binding protein 2	Sus scrofa	43-49
16249179-1	2005	Mammalian isoforms of acetyl-CoA carboxylase (ACC-1 and ACC-2) play important roles in synthesis, elongation, and oxidation of long-chain fatty acids, and the possible significance of ACC in the development of obesity has led to interest in the development of inhibitors.	long-chain fatty acids	127-149	acetyl-CoA carboxylase beta	Rattus norvegicus	56-61
16306812-1	2005	The antianginal agent perhexiline inhibits rat cardiac carnitine palmitoyltransferase-1 (CPT-1) and CPT-2, key enzymes for mitochondrial transport of long-chain fatty acids.	long-chain fatty acids	150-172	carnitine palmitoyltransferase 2	Rattus norvegicus	100-105
16223892-2	2005	In peroxisomes, a subfamily of four ABC transporters (ABCD1 to ABCD4) has been related to fatty acid transport, because patients with mutations in ABCD1 (ALD gene) suffer from X-linked adrenoleukodystrophy (X-ALD), a disease characterized by an accumulation of very-long-chain fatty acids (VLCFAs).	long-chain fatty acids	266-288	ATP binding cassette subfamily D member 1	Homo sapiens	54-59
16223892-2	2005	In peroxisomes, a subfamily of four ABC transporters (ABCD1 to ABCD4) has been related to fatty acid transport, because patients with mutations in ABCD1 (ALD gene) suffer from X-linked adrenoleukodystrophy (X-ALD), a disease characterized by an accumulation of very-long-chain fatty acids (VLCFAs).	long-chain fatty acids	266-288	ATP binding cassette subfamily D member 4	Homo sapiens	63-68
16223892-2	2005	In peroxisomes, a subfamily of four ABC transporters (ABCD1 to ABCD4) has been related to fatty acid transport, because patients with mutations in ABCD1 (ALD gene) suffer from X-linked adrenoleukodystrophy (X-ALD), a disease characterized by an accumulation of very-long-chain fatty acids (VLCFAs).	long-chain fatty acids	266-288	ATP binding cassette subfamily D member 1	Homo sapiens	147-152
16354187-3	2005	In particular, fatty acid transport proteins (FATP/solute carrier family 27) are integral transmembrane proteins that enhance the uptake of long-chain fatty acids into cells.	long-chain fatty acids	140-162	solute carrier family 27 member 1	Homo sapiens	46-50
16249461-1	2005	The intestinal fatty-acid binding protein-2 (FABP2) gene codes a protein responsible for the absorption of long-chain fatty acids.	long-chain fatty acids	107-129	fatty acid binding protein 2	Homo sapiens	45-50
16043284-2	2005	Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), an endoplasmic-reticulum-resident enzyme that catalyses the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids, modulates the generation of beta amyloid peptide (Abeta).	long-chain fatty acids	175-197	sterol O-acyltransferase 1	Homo sapiens	0-46
16043284-2	2005	Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), an endoplasmic-reticulum-resident enzyme that catalyses the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids, modulates the generation of beta amyloid peptide (Abeta).	long-chain fatty acids	175-197	acetyl-CoA acetyltransferase 1	Homo sapiens	48-53
16043284-2	2005	Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), an endoplasmic-reticulum-resident enzyme that catalyses the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids, modulates the generation of beta amyloid peptide (Abeta).	long-chain fatty acids	175-197	amyloid beta precursor protein	Homo sapiens	227-247
16043284-2	2005	Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), an endoplasmic-reticulum-resident enzyme that catalyses the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids, modulates the generation of beta amyloid peptide (Abeta).	long-chain fatty acids	175-197	amyloid beta precursor protein	Homo sapiens	249-254
16448220-1	2005	The function of adipose differentiation-related protein (ADRP) is known to be the uptake of long-chain fatty acids and formation of lipid droplets in lipid-accumulating cells.	long-chain fatty acids	92-114	perilipin 2	Rattus norvegicus	16-55
16448220-1	2005	The function of adipose differentiation-related protein (ADRP) is known to be the uptake of long-chain fatty acids and formation of lipid droplets in lipid-accumulating cells.	long-chain fatty acids	92-114	perilipin 2	Rattus norvegicus	57-61
15896819-5	2005	OCTN2 was not expressed in B-cells, notwithstanding that the metabolism of long-chain fatty acids, which are transported into the mitochondria with the help of carnitine, was expected for fatty acid-stimulated insulin secretion.	long-chain fatty acids	75-97	solute carrier family 22 (organic cation transporter), member 5	Mus musculus	0-5
15961790-1	2005	ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty acids.	long-chain fatty acids	72-94	sterol O-acyltransferase 1	Homo sapiens	0-4
15929861-1	2005	Acute increases in plasma levels of long-chain fatty acids raise plasma insulin levels by stimulating insulin secretion or by decreasing insulin clearance.	long-chain fatty acids	36-58	insulin	Homo sapiens	72-79
15929861-1	2005	Acute increases in plasma levels of long-chain fatty acids raise plasma insulin levels by stimulating insulin secretion or by decreasing insulin clearance.	long-chain fatty acids	36-58	insulin	Homo sapiens	102-109
15845636-6	2005	In this study, using in situ hybridization of the VLCAD and the LCHAD mRNA, we report on the expression of genes involved in the mitochondrial oxidation of long-chain fatty acids during early human development.	long-chain fatty acids	156-178	acyl-CoA dehydrogenase very long chain	Homo sapiens	50-55
15845636-6	2005	In this study, using in situ hybridization of the VLCAD and the LCHAD mRNA, we report on the expression of genes involved in the mitochondrial oxidation of long-chain fatty acids during early human development.	long-chain fatty acids	156-178	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	64-69
15878185-2	2005	Fatty acid synthase (FAS) catalyzes the condensation of acetyl-CoA and malonyl-CoA to generate long-chain fatty acids in the cytoplasm, while the breakdown of fatty acids (beta-oxidation) occurs in mitochondria and is regulated by carnitine palmitoyltransferase-1 (CPT-1), the rate-limiting step for the entry of fatty acids into the mitochondria.	long-chain fatty acids	95-117	fatty acid synthase	Homo sapiens	0-19
15878185-2	2005	Fatty acid synthase (FAS) catalyzes the condensation of acetyl-CoA and malonyl-CoA to generate long-chain fatty acids in the cytoplasm, while the breakdown of fatty acids (beta-oxidation) occurs in mitochondria and is regulated by carnitine palmitoyltransferase-1 (CPT-1), the rate-limiting step for the entry of fatty acids into the mitochondria.	long-chain fatty acids	95-117	fatty acid synthase	Homo sapiens	21-24
15885201-4	2005	PPARgamma also binds natural ligands such as long-chain fatty acids.	long-chain fatty acids	45-67	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
15871848-1	2005	BACKGROUND: Hormone sensitive lipase (HSL) plays a central role in free fatty acid homeostasis in adipose tissue and in pancreatic beta-cells, where it contributes to the control of insulin secretion by generating long-chain fatty acids.	long-chain fatty acids	214-236	lipase E, hormone sensitive type	Homo sapiens	12-36
15699031-4	2005	The yeast FATP orthologue, Fat1p, is a dual functional protein and is required for both the import of long-chain fatty acids and the activation of very long-chain fatty acids; these activities intrinsic to Fat1p are separable functions.	long-chain fatty acids	102-124	solute carrier family 27 (fatty acid transporter), member 1	Mus musculus	10-14
15699031-4	2005	The yeast FATP orthologue, Fat1p, is a dual functional protein and is required for both the import of long-chain fatty acids and the activation of very long-chain fatty acids; these activities intrinsic to Fat1p are separable functions.	long-chain fatty acids	102-124	long-chain fatty acid transporter FAT1	Saccharomyces cerevisiae S288C	27-32
15699031-4	2005	The yeast FATP orthologue, Fat1p, is a dual functional protein and is required for both the import of long-chain fatty acids and the activation of very long-chain fatty acids; these activities intrinsic to Fat1p are separable functions.	long-chain fatty acids	102-124	long-chain fatty acid transporter FAT1	Saccharomyces cerevisiae S288C	206-211
15699031-4	2005	The yeast FATP orthologue, Fat1p, is a dual functional protein and is required for both the import of long-chain fatty acids and the activation of very long-chain fatty acids; these activities intrinsic to Fat1p are separable functions.	long-chain fatty acids	152-174	solute carrier family 27 (fatty acid transporter), member 1	Mus musculus	10-14
15699031-4	2005	The yeast FATP orthologue, Fat1p, is a dual functional protein and is required for both the import of long-chain fatty acids and the activation of very long-chain fatty acids; these activities intrinsic to Fat1p are separable functions.	long-chain fatty acids	152-174	long-chain fatty acid transporter FAT1	Saccharomyces cerevisiae S288C	27-32
15699031-4	2005	The yeast FATP orthologue, Fat1p, is a dual functional protein and is required for both the import of long-chain fatty acids and the activation of very long-chain fatty acids; these activities intrinsic to Fat1p are separable functions.	long-chain fatty acids	152-174	long-chain fatty acid transporter FAT1	Saccharomyces cerevisiae S288C	206-211
15677481-4	2005	This study uncovered a significant activity of At4g05160 with medium-chain fatty acids, medium-chain fatty acids carrying a phenyl substitution, long-chain fatty acids, as well as the jasmonic acid precursors 12-oxo-phytodienoic acid and 3-oxo-2-(2"-pentenyl)-cyclopentane-1-hexanoic acid.	long-chain fatty acids	145-167	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	47-56
15677481-5	2005	The closest homolog of At4g05160, namely At5g63380, showed high activity with long-chain fatty acids and 12-oxo-phytodienoic acid, the latter representing the most efficiently converted substrate.	long-chain fatty acids	78-100	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	23-32
15677481-5	2005	The closest homolog of At4g05160, namely At5g63380, showed high activity with long-chain fatty acids and 12-oxo-phytodienoic acid, the latter representing the most efficiently converted substrate.	long-chain fatty acids	78-100	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	41-50
15749821-2	2005	An autosomal dominant form of Stargardt macular degeneration (STGD) is caused by mutations in ELOVL4, which is predicted to encode an enzyme involved in the elongation of long-chain fatty acids.	long-chain fatty acids	171-193	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4	Mus musculus	94-100
15579906-1	2005	Carnitine palmitoyltransferase (CPT) I catalyzes the conversion of long-chain fatty acyl-CoAs to acyl carnitines in the presence of l-carnitine, a rate-limiting step in the transport of long-chain fatty acids from the cytoplasm to the mitochondrial matrix.	long-chain fatty acids	186-208	carnitine palmitoyltransferase 1B	Homo sapiens	0-38
15871848-1	2005	BACKGROUND: Hormone sensitive lipase (HSL) plays a central role in free fatty acid homeostasis in adipose tissue and in pancreatic beta-cells, where it contributes to the control of insulin secretion by generating long-chain fatty acids.	long-chain fatty acids	214-236	lipase E, hormone sensitive type	Homo sapiens	38-41
15606695-1	2005	AIMS: Recently, a novel human G protein-coupled receptor 40 (GPR40), which is predominantly expressed in pancreatic islets, was shown to mediate an amplifying effect of long-chain fatty acids on glucose-induced insulin secretion.	long-chain fatty acids	169-191	free fatty acid receptor 1	Homo sapiens	30-59
15606695-1	2005	AIMS: Recently, a novel human G protein-coupled receptor 40 (GPR40), which is predominantly expressed in pancreatic islets, was shown to mediate an amplifying effect of long-chain fatty acids on glucose-induced insulin secretion.	long-chain fatty acids	169-191	free fatty acid receptor 1	Homo sapiens	61-66
15621070-8	2004	CPT 1alpha transfers long-chain fatty acids in the cytosol from CoA to carnitine, which is the precondition for the entry of long-chain fatty acids into mitochondria and the rate-controlling step in mitochondrial fatty acid oxidation.	long-chain fatty acids	21-43	carnitine palmitoyltransferase 1A	Rattus norvegicus	0-10
15356215-1	2005	Carnitine palmitoyltransferase 1beta (CPT-1beta) is a key regulator of the beta oxidation of long-chain fatty acids in skeletal muscle and therefore a potential therapeutic target for diseases associated with defects in lipid metabolism such as obesity and type 2 diabetes.	long-chain fatty acids	93-115	carnitine palmitoyltransferase 1B	Homo sapiens	0-36
15356215-1	2005	Carnitine palmitoyltransferase 1beta (CPT-1beta) is a key regulator of the beta oxidation of long-chain fatty acids in skeletal muscle and therefore a potential therapeutic target for diseases associated with defects in lipid metabolism such as obesity and type 2 diabetes.	long-chain fatty acids	93-115	carnitine palmitoyltransferase 1B	Homo sapiens	38-47
16374067-1	2005	OBJECTIVE: A key enzyme of fatty acid synthesis, fatty acid synthase (FAS), is expressed in human cancers, including squamous-cell carcinoma of the lung, and long-chain fatty acids are intracellularly transported and/or taken up from blood by fatty-acid-binding proteins (FABPs).	long-chain fatty acids	158-180	fatty acid synthase	Homo sapiens	49-68
16374067-1	2005	OBJECTIVE: A key enzyme of fatty acid synthesis, fatty acid synthase (FAS), is expressed in human cancers, including squamous-cell carcinoma of the lung, and long-chain fatty acids are intracellularly transported and/or taken up from blood by fatty-acid-binding proteins (FABPs).	long-chain fatty acids	158-180	fatty acid synthase	Homo sapiens	70-73
15808662-1	2005	OBJECTIVE: Liver fatty acid-binding protein (L-FABP) is a small protein (15 kD) involved in the intracellular transport of long-chain fatty acids in the liver.	long-chain fatty acids	123-145	fatty acid binding protein 1	Sus scrofa	11-43
15808662-1	2005	OBJECTIVE: Liver fatty acid-binding protein (L-FABP) is a small protein (15 kD) involved in the intracellular transport of long-chain fatty acids in the liver.	long-chain fatty acids	123-145	fatty acid binding protein 1	Sus scrofa	45-51
15621070-8	2004	CPT 1alpha transfers long-chain fatty acids in the cytosol from CoA to carnitine, which is the precondition for the entry of long-chain fatty acids into mitochondria and the rate-controlling step in mitochondrial fatty acid oxidation.	long-chain fatty acids	125-147	carnitine palmitoyltransferase 1A	Rattus norvegicus	0-10
15577262-5	2004	CPTI is a protein necessary for the beta-oxidation of long-chain fatty acids in mammalian mitochondria, and it has been suggested that at least two isoforms, the liver type and muscle (M-CPTI) type, exist.	long-chain fatty acids	54-76	carnitine palmitoyltransferase 1B	Homo sapiens	0-4
15516711-5	2004	CPTI is known to be a protein necessary for the beta-oxidation of long-chain fatty acids in mammalian mitochondria, and it has been suggested that at least two isoforms, the liver type and muscle type, exist.	long-chain fatty acids	66-88	carnitine palmitoyltransferase 1B	Homo sapiens	0-4
15591000-3	2004	CPT-I and CPT-II are crucial for the beta-oxidation of long-chain fatty acids in the mitochondria by enabling their transport across the mitochondrial membrane.	long-chain fatty acids	55-77	carnitine palmitoyltransferase 1B	Homo sapiens	0-5
15591000-3	2004	CPT-I and CPT-II are crucial for the beta-oxidation of long-chain fatty acids in the mitochondria by enabling their transport across the mitochondrial membrane.	long-chain fatty acids	55-77	carnitine palmitoyltransferase 2	Homo sapiens	10-16
15337740-4	2004	Liver fatty acid-binding protein (L-FABP) plays a role in the influx of long-chain fatty acids into hepatocytes.	long-chain fatty acids	72-94	fatty acid binding protein 1	Rattus norvegicus	0-32
15337740-4	2004	Liver fatty acid-binding protein (L-FABP) plays a role in the influx of long-chain fatty acids into hepatocytes.	long-chain fatty acids	72-94	fatty acid binding protein 1	Rattus norvegicus	34-40
15365988-1	2004	The enzyme carnitine-acylcarnitine translocase (CACT) is involved in the transport of long-chain fatty acids into mitochondria.	long-chain fatty acids	86-108	solute carrier family 25 member 20	Homo sapiens	11-46
15449958-1	2004	The outer mitochondrial membrane enzyme carnitine palmitoyltransferase I (CPTI) catalyzes the initial and regulatory step in the beta-oxidation of long-chain fatty acids.	long-chain fatty acids	147-169	carnitine palmitoyltransferase 1A	Rattus norvegicus	40-72
15449958-1	2004	The outer mitochondrial membrane enzyme carnitine palmitoyltransferase I (CPTI) catalyzes the initial and regulatory step in the beta-oxidation of long-chain fatty acids.	long-chain fatty acids	147-169	carnitine palmitoyltransferase 1A	Rattus norvegicus	74-78
15365988-1	2004	The enzyme carnitine-acylcarnitine translocase (CACT) is involved in the transport of long-chain fatty acids into mitochondria.	long-chain fatty acids	86-108	solute carrier family 25 member 20	Homo sapiens	48-52
15335354-7	2004	Twenty-two major differentially expressed spots were observed in serially passaged HDMECs and identified with high confidence by MALDI-TOF-MS. One of these spots was found to be a 14-15 kDa psoriasis-associated fatty acid-binding protein (PA-FABP) with high affinity for long-chain fatty acids.	long-chain fatty acids	271-293	fatty acid binding protein 5	Homo sapiens	190-237
15335354-7	2004	Twenty-two major differentially expressed spots were observed in serially passaged HDMECs and identified with high confidence by MALDI-TOF-MS. One of these spots was found to be a 14-15 kDa psoriasis-associated fatty acid-binding protein (PA-FABP) with high affinity for long-chain fatty acids.	long-chain fatty acids	271-293	fatty acid binding protein 5	Homo sapiens	239-246
15324484-12	2004	This may be due to the non-availability of long-chain fatty acids or other intracellular mediators that are transported by L-FABP to the nucleus.	long-chain fatty acids	43-65	fatty acid binding protein 1	Rattus norvegicus	123-129
15105415-4	2004	Two to 3-fold overexpression of L-CPT I, the endogenous isoform in L6 cells, proportionally increased oxidation of the long-chain fatty acids palmitate and oleate and increased insulin stimulation of [(14)C]glucose incorporation into glycogen by 60% while enhancing insulin-stimulated phosphorylation of p38MAPK.	long-chain fatty acids	119-141	carnitine palmitoyltransferase 1B	Homo sapiens	34-39
15325340-1	2004	The intestinal fatty acid-binding protein (I-FABP) shows binding specificity for long-chain fatty acids and is proposed to be involved in uptake of dietary fatty acids and their intracellular transport.	long-chain fatty acids	81-103	fatty acid binding protein 2, intestinal	Danio rerio	4-41
15325340-1	2004	The intestinal fatty acid-binding protein (I-FABP) shows binding specificity for long-chain fatty acids and is proposed to be involved in uptake of dietary fatty acids and their intracellular transport.	long-chain fatty acids	81-103	fatty acid binding protein 2, intestinal	Danio rerio	43-49
15127202-1	2004	AIMS/HYPOTHESIS: Defective oxidation of long-chain fatty acids is a feature of insulin resistance and Type 2 diabetes.	long-chain fatty acids	40-62	insulin	Homo sapiens	79-86
15173434-7	2004	Long-chain fatty acids are ligands for PPARalpha, and the fatty acid oxidation is promoted by several physiological conditions including exercise.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	39-48
15294037-8	2004	A higher utilization of plasma long-chain fatty acids during exercise in males compared with females could explain the gender-dependent influence of exercise training on FABPpm.	long-chain fatty acids	31-53	glutamic-oxaloacetic transaminase 2	Homo sapiens	170-176
14741707-1	2004	GPR40, which has recently been identified as a G-protein-coupled cell-surface receptor for long-chain fatty acids, was assessed in a human breast cancer cell line (MCF-7).	long-chain fatty acids	91-113	free fatty acid receptor 1	Homo sapiens	0-5
14741707-5	2004	These results indicate the possibility that GPR40 for long-chain fatty acids may be involved in cellular function such as cell proliferation, providing a new perspective for the action of long-chain fatty acids on mammary epithelial cells.	long-chain fatty acids	54-76	free fatty acid receptor 1	Homo sapiens	44-49
14741707-5	2004	These results indicate the possibility that GPR40 for long-chain fatty acids may be involved in cellular function such as cell proliferation, providing a new perspective for the action of long-chain fatty acids on mammary epithelial cells.	long-chain fatty acids	188-210	free fatty acid receptor 1	Homo sapiens	44-49
14999402-2	2004	They mediate the effects of small lipophilic compounds such as long-chain fatty acids and their derivatives on transcription of genes commonly called PPAR target genes.	long-chain fatty acids	63-85	peroxisome proliferator activated receptor alpha	Homo sapiens	150-154
14656998-1	2004	Liver fatty acid binding protein (L-FABP) has been proposed to limit the availability of long-chain fatty acids (LCFA) for oxidation and for peroxisome proliferator-activated receptor alpha (PPAR-alpha), a fatty acid binding transcription factor that determines the capacity of hepatic fatty acid oxidation.	long-chain fatty acids	89-111	fatty acid binding protein 1, liver	Mus musculus	0-32
14656998-1	2004	Liver fatty acid binding protein (L-FABP) has been proposed to limit the availability of long-chain fatty acids (LCFA) for oxidation and for peroxisome proliferator-activated receptor alpha (PPAR-alpha), a fatty acid binding transcription factor that determines the capacity of hepatic fatty acid oxidation.	long-chain fatty acids	89-111	fatty acid binding protein 1, liver	Mus musculus	34-40
12954596-1	2004	Carnitine palmitoyltransferase I (CPT I) is considered the rate-limiting enzyme in the transfer of long-chain fatty acids (LCFA) into the mitochondria and is reversibly inhibited by malonyl-CoA (M-CoA) in vitro.	long-chain fatty acids	99-121	carnitine palmitoyltransferase 1B	Homo sapiens	0-32
12954596-1	2004	Carnitine palmitoyltransferase I (CPT I) is considered the rate-limiting enzyme in the transfer of long-chain fatty acids (LCFA) into the mitochondria and is reversibly inhibited by malonyl-CoA (M-CoA) in vitro.	long-chain fatty acids	99-121	carnitine palmitoyltransferase 1B	Homo sapiens	34-39
14500732-6	2003	We conclude that disruption of peroxisomal fatty acid beta-oxidation at the level of second enzyme in mice leads to the induction of many of the PPARalpha target genes independently of peroxisome proliferation in hepatocytes, raising the possibility that intermediate metabolites of very long-chain fatty acids and peroxisomal beta-oxidation act as ligands for PPARalpha.	long-chain fatty acids	288-310	peroxisome proliferator activated receptor alpha	Mus musculus	145-154
14525936-6	2003	Second, inhibition of mitochondrial entry of esterified long-chain fatty acids up-regulated UCP3 by 1.9-fold.	long-chain fatty acids	56-78	uncoupling protein 3	Homo sapiens	92-96
14525936-7	2003	Third, high-fat diets, to increase mitochondrial supply of non-esterified long-chain fatty acids exceeding oxidative capacity, up-regulated UCP3 twofold.	long-chain fatty acids	74-96	uncoupling protein 3	Homo sapiens	140-144
14592453-7	2003	The long-chain fatty acids stearate (18:0), arachidate (20:0), and lignocerate (24:0) reproduced palmitate"s effects on these events, while saturated fatty acids with shorter hydrocarbon chains [i.e., laurate (12:0) and myristate (14:0)] failed to induce ceramide accumulation or inhibit Akt/PKB activation.	long-chain fatty acids	4-26	AKT serine/threonine kinase 1	Rattus norvegicus	288-291
14592453-7	2003	The long-chain fatty acids stearate (18:0), arachidate (20:0), and lignocerate (24:0) reproduced palmitate"s effects on these events, while saturated fatty acids with shorter hydrocarbon chains [i.e., laurate (12:0) and myristate (14:0)] failed to induce ceramide accumulation or inhibit Akt/PKB activation.	long-chain fatty acids	4-26	AKT serine/threonine kinase 1	Rattus norvegicus	292-295
12736159-8	2003	These results demonstrate that long-chain fatty acids mimic the effects of norepinephrine on leptin secretion and suggest that they may play a regulatory role as messengers between stimulation of lipolysis by norepinephrine and inhibition of leptin secretion.	long-chain fatty acids	31-53	leptin	Rattus norvegicus	93-99
12975357-5	2003	The expression pattern and ability of BG1 to activate very long-chain fatty acids implicates this enzyme in the pathogenesis of X-linked adrenoleukodystrophy.	long-chain fatty acids	59-81	acyl-CoA synthetase bubblegum family member 1	Mus musculus	38-41
12975357-8	2003	These results suggest that in Neuro2a cells, mBG1-activated long-chain fatty acids are directed toward mitochondrial degradation.	long-chain fatty acids	60-82	acyl-CoA synthetase bubblegum family member 1	Mus musculus	45-49
12736159-8	2003	These results demonstrate that long-chain fatty acids mimic the effects of norepinephrine on leptin secretion and suggest that they may play a regulatory role as messengers between stimulation of lipolysis by norepinephrine and inhibition of leptin secretion.	long-chain fatty acids	31-53	leptin	Rattus norvegicus	242-248
12864741-1	2003	The intracellular transport of long-chain fatty acids in muscle cells is facilitated to a great extent by heart-type cytoplasmic fatty acid-binding protein (H-FABP).	long-chain fatty acids	31-53	fatty acid binding protein 3, muscle and heart	Mus musculus	106-155
12810727-6	2003	However, BACAT is also expressed in a variety of tissues unrelated to bile acid formation and transport, suggesting important functions also in the regulation of intracellular levels of very long-chain fatty acids.	long-chain fatty acids	191-213	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	9-14
12810727-8	2003	Therefore, the cytosolic BACAT enzyme may play important roles in protection against toxicity by accumulation of unconjugated bile acids and non-esterified very long-chain fatty acids.	long-chain fatty acids	161-183	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	25-30
12864741-1	2003	The intracellular transport of long-chain fatty acids in muscle cells is facilitated to a great extent by heart-type cytoplasmic fatty acid-binding protein (H-FABP).	long-chain fatty acids	31-53	fatty acid binding protein 3, muscle and heart	Mus musculus	157-163
12810950-1	2003	Acetyl-CoA carboxylase 1 (ACC1) catalyzes the formation of malonyl-CoA, the C2 donor for de novo synthesis of long-chain fatty acids.	long-chain fatty acids	110-132	acetyl-CoA carboxylase alpha	Homo sapiens	0-24
12892634-3	2003	Here, we describe the molecular characterization of extant acuH alleles and the development of a fungal model for CACT deficiency based on the ability of human CACT to fully complement, when expressed at physiological levels, the growth defect of an A. nidulans DeltaacuH strain on acetate and long-chain fatty acids.	long-chain fatty acids	294-316	solute carrier family 25 member 20	Homo sapiens	114-118
12892634-3	2003	Here, we describe the molecular characterization of extant acuH alleles and the development of a fungal model for CACT deficiency based on the ability of human CACT to fully complement, when expressed at physiological levels, the growth defect of an A. nidulans DeltaacuH strain on acetate and long-chain fatty acids.	long-chain fatty acids	294-316	solute carrier family 25 member 20	Homo sapiens	160-164
12909364-3	2003	INCL is caused by mutations in the palmitoyl-protein thioesterase 1 (PPT1) gene, which encodes a palmitoyl-protein thioesterase 1 enzyme that cleaves long-chain fatty acids from S-acylated proteins within the lysosome.	long-chain fatty acids	150-172	Palmitoyl-protein thioesterase 1	Drosophila melanogaster	35-67
12909364-3	2003	INCL is caused by mutations in the palmitoyl-protein thioesterase 1 (PPT1) gene, which encodes a palmitoyl-protein thioesterase 1 enzyme that cleaves long-chain fatty acids from S-acylated proteins within the lysosome.	long-chain fatty acids	150-172	Palmitoyl-protein thioesterase 1	Drosophila melanogaster	69-73
12909364-3	2003	INCL is caused by mutations in the palmitoyl-protein thioesterase 1 (PPT1) gene, which encodes a palmitoyl-protein thioesterase 1 enzyme that cleaves long-chain fatty acids from S-acylated proteins within the lysosome.	long-chain fatty acids	150-172	Palmitoyl-protein thioesterase 1	Drosophila melanogaster	97-129
12810950-1	2003	Acetyl-CoA carboxylase 1 (ACC1) catalyzes the formation of malonyl-CoA, the C2 donor for de novo synthesis of long-chain fatty acids.	long-chain fatty acids	110-132	acetyl-CoA carboxylase alpha	Homo sapiens	26-30
12796309-1	2003	Beta-oxidation of long-chain fatty acids and branched-chain fatty acids is carried out in mammalian peroxisomes by a multifunctional enzyme (MFE) or D-bifunctional protein, with separate domains for hydroxyacyl coenzyme A (CoA) dehydrogenase, enoyl-CoA hydratase, and steroid carrier protein SCP2.	long-chain fatty acids	18-40	sterol carrier protein 2	Homo sapiens	292-296
12746301-0	2003	In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters.	long-chain fatty acids	51-73	insulin degrading enzyme	Rattus norvegicus	23-47
12719378-2	2003	The biochemical signature of X-ALD is increased levels of saturated very long-chain fatty acids (VLCFA; carbon chains of 22 or more) in tissues and plasma that has been associated with decreased peroxisomal very long-chain acyl-CoA synthetase (VLCS) activity and decreased peroxisomal VLCFA beta-oxidation.	long-chain fatty acids	73-95	solute carrier family 27 (fatty acid transporter), member 2	Mus musculus	207-242
12819639-5	2003	Second, long-chain fatty acids inhibited 3alpha-hydroxysteroid dehydrogenase activity.	long-chain fatty acids	8-30	aldo-keto reductase family 1 member C3	Homo sapiens	41-76
12971426-3	2003	All enzymes were found to be expressed, with a very high activity of two enzymes involved in the metabolism of long-chain fatty acids (CPT2 and VLCAD), whereas the activity of medium-chain acyl-CoA dehydrogenase (MCAD) was found to be low, when compared to liver.	long-chain fatty acids	111-133	carnitine palmitoyltransferase 2	Homo sapiens	135-139
12644315-11	2003	Long-chain fatty acids dose-dependently inhibited the stimulated-IFN-gamma production at concentrations greater than 10 micro M, but the medium-chain fatty acid did not cause any significant changes in IFN-gamma production.	long-chain fatty acids	0-22	interferon gamma	Mus musculus	65-74
12646277-2	2003	The H(+) transport activity of UCP1 is activated by long-chain fatty acids and inhibited by purine nucleotides.	long-chain fatty acids	52-74	uncoupling protein 1	Homo sapiens	31-35
12609736-1	2003	Very-long-chain acyl-CoA dehydrogenase (VLCAD) is a major enzyme catalysing the first step in mitochondrial beta-oxidation of long-chain fatty acids.	long-chain fatty acids	126-148	acyl-CoA dehydrogenase very long chain	Homo sapiens	0-38
12609736-1	2003	Very-long-chain acyl-CoA dehydrogenase (VLCAD) is a major enzyme catalysing the first step in mitochondrial beta-oxidation of long-chain fatty acids.	long-chain fatty acids	126-148	acyl-CoA dehydrogenase very long chain	Homo sapiens	40-45
12548384-1	2003	UNLABELLED: The mitochondrial trifunctional protein (MTP) is a multienzyme complex which catalyses three of the four chain-shortening reactions in the beta-oxidation of long-chain fatty acids.	long-chain fatty acids	169-191	microsomal triglyceride transfer protein	Homo sapiens	16-51
12548384-1	2003	UNLABELLED: The mitochondrial trifunctional protein (MTP) is a multienzyme complex which catalyses three of the four chain-shortening reactions in the beta-oxidation of long-chain fatty acids.	long-chain fatty acids	169-191	microsomal triglyceride transfer protein	Homo sapiens	53-56
12971426-3	2003	All enzymes were found to be expressed, with a very high activity of two enzymes involved in the metabolism of long-chain fatty acids (CPT2 and VLCAD), whereas the activity of medium-chain acyl-CoA dehydrogenase (MCAD) was found to be low, when compared to liver.	long-chain fatty acids	111-133	acyl-CoA dehydrogenase very long chain	Homo sapiens	144-149
12531555-4	2002	If nonadipose tissues are exposed to an excess of long-chain fatty acids, unless leptin action increases their oxidation sufficiently, unoxidized fatty acids enter nonoxidative pathways.	long-chain fatty acids	50-72	leptin	Homo sapiens	81-87
12479579-1	2002	The fatty acid-binding protein (FABP) superfamily is constituted by 14-15 kDa soluble proteins which bind with a high affinity either long-chain fatty acids (LCFAs), bile acids (BAs) or retinoids.	long-chain fatty acids	134-156	glutamic-oxaloacetic transaminase 2	Homo sapiens	4-30
12464674-3	2002	We hypothesized that the transfer of long-chain fatty acids (LCFAs) into the mitochondria via carnitine palmitoyltransferase-1 (CPT-1) is inhibited by increased malonyl coenzyme A (malonyl-CoA) (a known potent inhibitor of CPT-1) in human muscle during hyperglycemia with hyperinsulinemia.	long-chain fatty acids	37-59	carnitine palmitoyltransferase 1A	Homo sapiens	94-126
12464674-3	2002	We hypothesized that the transfer of long-chain fatty acids (LCFAs) into the mitochondria via carnitine palmitoyltransferase-1 (CPT-1) is inhibited by increased malonyl coenzyme A (malonyl-CoA) (a known potent inhibitor of CPT-1) in human muscle during hyperglycemia with hyperinsulinemia.	long-chain fatty acids	37-59	carnitine palmitoyltransferase 1A	Homo sapiens	128-133
12464674-3	2002	We hypothesized that the transfer of long-chain fatty acids (LCFAs) into the mitochondria via carnitine palmitoyltransferase-1 (CPT-1) is inhibited by increased malonyl coenzyme A (malonyl-CoA) (a known potent inhibitor of CPT-1) in human muscle during hyperglycemia with hyperinsulinemia.	long-chain fatty acids	37-59	carnitine palmitoyltransferase 1A	Homo sapiens	223-228
12416806-7	2002	The decrease in long-chain fatty acids, related to the decreased mammary uptake of plasma total glycerides, was likely due to a decrease in lipoprotein lipase and esterification activities.	long-chain fatty acids	16-38	lipoprotein lipase	Bos taurus	140-158
12479570-8	2002	It is speculated that recruitment of an iLBP during evolution of animals enabled the mitochondrial oxidation of long-chain fatty acids.	long-chain fatty acids	112-134	fatty acid binding protein 6	Homo sapiens	40-44
12479579-1	2002	The fatty acid-binding protein (FABP) superfamily is constituted by 14-15 kDa soluble proteins which bind with a high affinity either long-chain fatty acids (LCFAs), bile acids (BAs) or retinoids.	long-chain fatty acids	134-156	glutamic-oxaloacetic transaminase 2	Homo sapiens	32-36
12479583-4	2002	The promoter activity was studied with reporter gene constructs in L6 myoblasts, in which H-FABP expression is stimulated by long-chain fatty acids in a similar manner as in adult cardiomyocytes.	long-chain fatty acids	125-147	fatty acid binding protein 3	Rattus norvegicus	90-96
12110517-2	2002	Exposure to long-chain fatty acids led to significant increases (2-fold) in MCAD mRNA abundance in RC.SV1 and RC.SV2 cells; kinetics and dose-response studies established that maximal MCAD gene stimulation was reached 4 h after addition of 50 microM oleate (C18:1) in the culture medium.	long-chain fatty acids	12-34	medium-chain specific acyl-CoA dehydrogenase, mitochondrial	Oryctolagus cuniculus	76-80
12189492-2	2002	CPT1 controls the import of long-chain fatty acids into the mitochondria, where they are oxidized.	long-chain fatty acids	28-50	carnitine palmitoyltransferase 1A	Homo sapiens	0-4
12110517-2	2002	Exposure to long-chain fatty acids led to significant increases (2-fold) in MCAD mRNA abundance in RC.SV1 and RC.SV2 cells; kinetics and dose-response studies established that maximal MCAD gene stimulation was reached 4 h after addition of 50 microM oleate (C18:1) in the culture medium.	long-chain fatty acids	12-34	medium-chain specific acyl-CoA dehydrogenase, mitochondrial	Oryctolagus cuniculus	184-188
12015320-1	2002	Muscle-type carnitine palmitoyltransferase I (M-CPT I) is a key enzyme in the control of beta-oxidation of long-chain fatty acids in the heart and skeletal muscle.	long-chain fatty acids	107-129	carnitine palmitoyltransferase 1B	Homo sapiens	48-53
11969406-1	2002	Uniformly (13)C-labeled long-chain fatty acids were used to probe ligand binding to rat liver fatty acid-binding protein (LFABP), an atypical member of the fatty acid-binding protein (FABP) family that binds more than one molecule of long-chain fatty acid, accommodates a variety of diverse ligands, and exhibits diffusion-mediated lipid transport to membranes.	long-chain fatty acids	24-46	fatty acid binding protein 1	Rattus norvegicus	122-127
11867619-1	2002	Fatty acid translocase (FAT)/CD36 is a glycoprotein involved in multiple membrane functions including uptake of long-chain fatty acids and oxidized low density lipoprotein.	long-chain fatty acids	112-134	CD36 molecule	Homo sapiens	0-22
11867619-1	2002	Fatty acid translocase (FAT)/CD36 is a glycoprotein involved in multiple membrane functions including uptake of long-chain fatty acids and oxidized low density lipoprotein.	long-chain fatty acids	112-134	CD36 molecule	Homo sapiens	24-27
11928954-13	2001	At age 40 d, plasma triglyceride in the beta-lg-fed group was higher (P < 0.05) than in the control group only at 9 h. Ratios of palmitic, stearic, and oleic acids to total plasma lipids were higher (P < 0.05) in the calves fed beta-lg milk than in the control calves at age 10 d. These results suggest that beta-lg enhances the intestinal uptake of retinol, triglyceride, and long-chain fatty acids in preruminant calves.	long-chain fatty acids	383-405	beta-lactoglobulin	Bos taurus	40-47
11878804-1	2002	Carnitine palmitoyltransferase II (CPT-II) mediates the import of long-chain fatty acids into the mitochondrial matrix for subsequent beta-oxidation.	long-chain fatty acids	66-88	carnitine palmitoyltransferase 2	Homo sapiens	0-33
11878804-1	2002	Carnitine palmitoyltransferase II (CPT-II) mediates the import of long-chain fatty acids into the mitochondrial matrix for subsequent beta-oxidation.	long-chain fatty acids	66-88	carnitine palmitoyltransferase 2	Homo sapiens	35-41
11809922-2	2002	Recently, it has been suggested that ADR inhibits the carnitine palmitoyltransferase system (CPT I) and consequently the transport of long-chain fatty acids across mitochondrial membranes.	long-chain fatty acids	134-156	carnitine palmitoyltransferase 1B	Rattus norvegicus	93-98
16233300-4	2002	These results suggest that Plc1p is normally functional for phospholipid reconstitution in exponentially growing cells and enhancement of its activity by exogenous Mg2+ could be a cause of the irreversible deacylation of plasma membrane phospholipids when their reacylation is blocked at the step of activation of long-chain fatty acids by one of the Faap isozymes.	long-chain fatty acids	314-336	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	27-32
11748843-1	2001	X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene, which encodes a peroxisomal ABC half-transporter (ALDP) involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.	long-chain fatty acids	167-189	ATP binding cassette subfamily D member 1	Homo sapiens	68-73
11748843-1	2001	X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene, which encodes a peroxisomal ABC half-transporter (ALDP) involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.	long-chain fatty acids	167-189	ATP binding cassette subfamily D member 1	Homo sapiens	130-134
11834092-3	2001	Long-chain fatty acids (FA) have been named the "one true" endogenous ligand for activating the peroxisome proliferator-activator receptor (PPAR), and DHEA has been named a "good candidate" as a naturally occurring indirect activator of PPAR.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	96-138
11834092-3	2001	Long-chain fatty acids (FA) have been named the "one true" endogenous ligand for activating the peroxisome proliferator-activator receptor (PPAR), and DHEA has been named a "good candidate" as a naturally occurring indirect activator of PPAR.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	140-144
11928954-2	2001	Although beta-lg can bind in vitro to a variety of hydrophobic substrates, mainly retinol and long-chain fatty acids, its physiological function is still unknown.	long-chain fatty acids	94-116	beta-lactoglobulin	Bos taurus	9-16
11785933-4	2001	CHAPS-solubilized recombinant ACS6 protein preferred utilising long-chain fatty acids that contained a cis-9 double bond, i.e. palmitoleic, oleic, linoleic and linolenic acids.	long-chain fatty acids	63-85	long chain acyl-CoA synthetase 9, chloroplastic	Brassica napus	30-34
11441142-1	2001	Carnitine palmitoyltransferase I (CPT I) catalyzes the formation of acylcarnitine, the first step in the oxidation of long-chain fatty acids in mitochondria.	long-chain fatty acids	118-140	carnitine palmitoyltransferase 1B	Homo sapiens	0-32
11485560-1	2001	The enzyme acetyl-CoA carboxylase alpha (ACC-alpha) is rate-limiting for the synthesis of long-chain fatty acids de novo.	long-chain fatty acids	90-112	acetyl-CoA carboxylase alpha	Bos taurus	11-39
11485560-1	2001	The enzyme acetyl-CoA carboxylase alpha (ACC-alpha) is rate-limiting for the synthesis of long-chain fatty acids de novo.	long-chain fatty acids	90-112	acetyl-CoA carboxylase alpha	Bos taurus	41-50
11694623-6	2001	Administration of long-chain fatty acids significantly increased the GRO/CINC-1 and IL-6 secretion into culture media, and this secretion was markedly increased (P < 0.05) in the presence of IL-1beta or TGF-beta.	long-chain fatty acids	18-40	C-X-C motif chemokine ligand 1	Rattus norvegicus	69-72
11694623-6	2001	Administration of long-chain fatty acids significantly increased the GRO/CINC-1 and IL-6 secretion into culture media, and this secretion was markedly increased (P < 0.05) in the presence of IL-1beta or TGF-beta.	long-chain fatty acids	18-40	C-X-C motif chemokine ligand 1	Rattus norvegicus	73-79
11694623-6	2001	Administration of long-chain fatty acids significantly increased the GRO/CINC-1 and IL-6 secretion into culture media, and this secretion was markedly increased (P < 0.05) in the presence of IL-1beta or TGF-beta.	long-chain fatty acids	18-40	interleukin 6	Rattus norvegicus	84-88
11694623-6	2001	Administration of long-chain fatty acids significantly increased the GRO/CINC-1 and IL-6 secretion into culture media, and this secretion was markedly increased (P < 0.05) in the presence of IL-1beta or TGF-beta.	long-chain fatty acids	18-40	interleukin 1 beta	Rattus norvegicus	194-202
11694623-6	2001	Administration of long-chain fatty acids significantly increased the GRO/CINC-1 and IL-6 secretion into culture media, and this secretion was markedly increased (P < 0.05) in the presence of IL-1beta or TGF-beta.	long-chain fatty acids	18-40	transforming growth factor, beta 1	Rattus norvegicus	206-214
11694623-8	2001	Furthermore, treatment with long-chain fatty acids significantly enhanced the GRO/CINC-1 and IL-6 expression that was induced by IL-1beta or TGF-beta.	long-chain fatty acids	28-50	C-X-C motif chemokine ligand 1	Rattus norvegicus	78-81
11694623-8	2001	Furthermore, treatment with long-chain fatty acids significantly enhanced the GRO/CINC-1 and IL-6 expression that was induced by IL-1beta or TGF-beta.	long-chain fatty acids	28-50	C-X-C motif chemokine ligand 1	Rattus norvegicus	82-88
11694623-8	2001	Furthermore, treatment with long-chain fatty acids significantly enhanced the GRO/CINC-1 and IL-6 expression that was induced by IL-1beta or TGF-beta.	long-chain fatty acids	28-50	interleukin 6	Rattus norvegicus	93-97
11694623-8	2001	Furthermore, treatment with long-chain fatty acids significantly enhanced the GRO/CINC-1 and IL-6 expression that was induced by IL-1beta or TGF-beta.	long-chain fatty acids	28-50	interleukin 1 beta	Rattus norvegicus	129-137
11694623-8	2001	Furthermore, treatment with long-chain fatty acids significantly enhanced the GRO/CINC-1 and IL-6 expression that was induced by IL-1beta or TGF-beta.	long-chain fatty acids	28-50	transforming growth factor, beta 1	Rattus norvegicus	141-149
11551854-1	2001	The aim of this study was to investigate the interaction between long-chain fatty acids (LCFA) and growth hormone (GH) in the regulation of liver fatty acid binding protein (LFABP) and peroxisome proliferator-activated receptor-alpha (PPARalpha).	long-chain fatty acids	65-87	fatty acid binding protein 1	Rattus norvegicus	174-179
11551854-1	2001	The aim of this study was to investigate the interaction between long-chain fatty acids (LCFA) and growth hormone (GH) in the regulation of liver fatty acid binding protein (LFABP) and peroxisome proliferator-activated receptor-alpha (PPARalpha).	long-chain fatty acids	65-87	peroxisome proliferator activated receptor alpha	Rattus norvegicus	185-233
11551854-1	2001	The aim of this study was to investigate the interaction between long-chain fatty acids (LCFA) and growth hormone (GH) in the regulation of liver fatty acid binding protein (LFABP) and peroxisome proliferator-activated receptor-alpha (PPARalpha).	long-chain fatty acids	65-87	peroxisome proliferator activated receptor alpha	Rattus norvegicus	235-244
11446882-0	2001	Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids.	long-chain fatty acids	107-129	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
11441142-1	2001	Carnitine palmitoyltransferase I (CPT I) catalyzes the formation of acylcarnitine, the first step in the oxidation of long-chain fatty acids in mitochondria.	long-chain fatty acids	118-140	carnitine palmitoyltransferase 1B	Homo sapiens	34-39
11278959-5	2001	In order to understand why gelatinases are more susceptible than collagenase-1 to inhibition by long-chain fatty acids, the possible role of the fibronectin-like domain (a domain unique to gelatinases) in binding inhibitory fatty acids was investigated.	long-chain fatty acids	96-118	fibronectin 1	Homo sapiens	145-156
11278959-6	2001	Affinity and kinetic studies with a recombinant fibronectin-like domain of gelatinase A and with a recombinant mutant of gelatinase A from which this domain had been deleted pointed to an interaction of long-chain fatty acids with the fibronectin-like domain of the protease.	long-chain fatty acids	203-225	fibronectin 1	Homo sapiens	48-59
11278959-2	2001	In the present study, we show that long-chain fatty acids (e.g. oleic acid, elaidic acid, and cis- and trans-parinaric acids) inhibit gelatinase A as well as gelatinase B with K(i) values in the micromolar range but had only weak inhibitory effect on collagenase-1 (MMP-1), as assessed using synthetic or natural substrates.	long-chain fatty acids	35-57	matrix metallopeptidase 1	Homo sapiens	266-271
11278959-6	2001	Affinity and kinetic studies with a recombinant fibronectin-like domain of gelatinase A and with a recombinant mutant of gelatinase A from which this domain had been deleted pointed to an interaction of long-chain fatty acids with the fibronectin-like domain of the protease.	long-chain fatty acids	203-225	fibronectin 1	Homo sapiens	235-246
11278959-7	2001	Surface plasmon resonance studies on the interaction of long-chain fatty acids with the three individual type II modules of the fibronectin-like domain of gelatinase A revealed that the first type II module is primarily responsible for binding these compounds.	long-chain fatty acids	56-78	fibronectin 1	Homo sapiens	128-139
11284737-1	2001	Liver fatty-acid-binding protein (L-FABP) is a cytoplasmic polypeptide that binds with strong affinity especially to long-chain fatty acids (LCFAs).	long-chain fatty acids	117-139	fatty acid binding protein 1, liver	Mus musculus	0-32
11506175-1	2001	The induction of cardiac FABP expression by long-chain fatty acids was measured in cultured rat myoblasts, myotubes and adult cardiomyocytes.	long-chain fatty acids	44-66	fatty acid binding protein 2	Rattus norvegicus	25-29
11284737-1	2001	Liver fatty-acid-binding protein (L-FABP) is a cytoplasmic polypeptide that binds with strong affinity especially to long-chain fatty acids (LCFAs).	long-chain fatty acids	117-139	fatty acid binding protein 1, liver	Mus musculus	34-40
11383693-0	2001	Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells.	long-chain fatty acids	14-36	cholesteryl ester transfer protein	Homo sapiens	58-92
11284692-3	2001	A wide variety of hydrophobic modifications increased the potency of Shh when added at the N-terminus of the protein, ranging from long-chain fatty acids to hydrophobic amino acids, with EC(50) values from 99 nM for the unmodified protein to 0.6 nM for the myristoylated form.	long-chain fatty acids	131-153	sonic hedgehog signaling molecule	Homo sapiens	69-72
10954726-1	2000	Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids.	long-chain fatty acids	81-103	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	7-17
11171094-0	2001	Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway.	long-chain fatty acids	0-22	carnitine palmitoyltransferase 1a, liver	Mus musculus	32-70
11171094-0	2001	Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway.	long-chain fatty acids	0-22	carnitine palmitoyltransferase 1a, liver	Mus musculus	77-84
11171094-0	2001	Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Mus musculus	107-155
11171094-0	2001	Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Mus musculus	157-166
11272168-1	2001	A recently identified function of leptin is to protect nonadipose tissues from the nonoxidative metabolic products of long-chain fatty acids (FAs) during periods of overnutrition by increasing the beta-oxidative metabolism of surplus FAs and reducing lipogenesis.	long-chain fatty acids	118-140	leptin	Homo sapiens	34-40
11181833-1	2001	Myelin proteolipid protein (PLP) contains thioester-bound, long-chain fatty acids which are known to influence the structure of the molecule.	long-chain fatty acids	59-81	proteolipid protein 1	Rattus norvegicus	0-32
11341955-6	2001	The up-regulation of UCP-2 was also found in cultured intestinal epithelial cells (IEC-6) treated for 24 h with various long-chain fatty acids and PPARalpha agonists.	long-chain fatty acids	120-142	uncoupling protein 2	Rattus norvegicus	21-26
10991946-2	2000	Ectopic expression of the nuclear receptors PPARgamma or PPARdelta promotes adipogenesis in fibroblastic cells exposed to thiazolidinediones or long-chain fatty acids.	long-chain fatty acids	144-166	peroxisome proliferator activated receptor gamma	Mus musculus	44-53
10991946-2	2000	Ectopic expression of the nuclear receptors PPARgamma or PPARdelta promotes adipogenesis in fibroblastic cells exposed to thiazolidinediones or long-chain fatty acids.	long-chain fatty acids	144-166	peroxisome proliferator activator receptor delta	Mus musculus	57-66
11093925-1	2000	Acyl-CoA synthetase (ACS) catalyzes the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO(2), triacylglycerol (TAG), phospholipids (PL), and cholesteryl esters (CE).	long-chain fatty acids	54-76	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	0-19
11093925-1	2000	Acyl-CoA synthetase (ACS) catalyzes the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO(2), triacylglycerol (TAG), phospholipids (PL), and cholesteryl esters (CE).	long-chain fatty acids	54-76	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	21-24
10915637-1	2000	Long-chain fatty acids are potent stimulants of secretin and CCK release.	long-chain fatty acids	0-22	secretin	Rattus norvegicus	48-56
11076785-7	2000	- CONCLUSION: Cardiac endothelial cells and cardiomyocytes express FAT and FATP1 in vivo, suggesting an active part of these proteins in the uptake process of long-chain fatty acids.	long-chain fatty acids	159-181	CD36 molecule	Mus musculus	67-70
11076785-7	2000	- CONCLUSION: Cardiac endothelial cells and cardiomyocytes express FAT and FATP1 in vivo, suggesting an active part of these proteins in the uptake process of long-chain fatty acids.	long-chain fatty acids	159-181	solute carrier family 27 (fatty acid transporter), member 1	Mus musculus	75-80
10926831-0	2000	Peroxisome-proliferator-activated receptor delta mediates the effects of long-chain fatty acids on post-confluent cell proliferation.	long-chain fatty acids	73-95	peroxisome proliferator activator receptor delta	Mus musculus	0-48
10926831-7	2000	Ectopic expression of PPARdelta renders 3T3C2 cells capable of responding to treatment with long-chain fatty acids by a resumption of mitosis, and this effect is limited to a few days after confluence.	long-chain fatty acids	92-114	peroxisome proliferator activator receptor delta	Mus musculus	22-31
11063720-9	2000	Consequently, increased amounts of mutated ALDP resulted in decreased peroxisomal beta-oxidation and accumulation of very long-chain fatty acids.	long-chain fatty acids	122-144	ATP binding cassette subfamily D member 1	Homo sapiens	43-47
10915637-1	2000	Long-chain fatty acids are potent stimulants of secretin and CCK release.	long-chain fatty acids	0-22	cholecystokinin	Rattus norvegicus	61-64
10880966-3	2000	The FAT1 gene encodes a protein, Fat1p, which is required for maximal levels of fatty-acid import and has an acyl CoA synthetase activity specific for very-long-chain fatty acids suggesting this protein plays a pivotal role in fatty-acid trafficking.	long-chain fatty acids	156-178	long-chain fatty acid transporter FAT1	Saccharomyces cerevisiae S288C	4-8
11282301-4	2000	Among the ligand activators of PPARalpha are long-chain fatty acids; therefore, increased uptake of fatty acid substrate into the cardiac myocyte induces a transcriptional response leading to increased expression of FAO enzymes.	long-chain fatty acids	45-67	peroxisome proliferator activated receptor alpha	Homo sapiens	31-40
10880966-3	2000	The FAT1 gene encodes a protein, Fat1p, which is required for maximal levels of fatty-acid import and has an acyl CoA synthetase activity specific for very-long-chain fatty acids suggesting this protein plays a pivotal role in fatty-acid trafficking.	long-chain fatty acids	156-178	long-chain fatty acid transporter FAT1	Saccharomyces cerevisiae S288C	33-38
10880966-14	2000	Fat1p or FATP also restored wild-type levels of beta-oxidation of exogenous long-chain fatty acids.	long-chain fatty acids	76-98	long-chain fatty acid transporter FAT1	Saccharomyces cerevisiae S288C	0-5
10880966-6	2000	FAT1 disruptants (fat1Delta) fail to accumulate the fluorescent long-chain fatty acid fatty-acid analogue 4, 4-difluoro-5-methyl-4-bora-3a,4a-diaza-s-indacene-3-do decanoic acid (C1-BODIPY-C12), have a greatly diminished capacity to transport exogenous long-chain fatty acids, and have very long-chain acyl CoA synthetase activities that were 40% wild-type.	long-chain fatty acids	253-275	long-chain fatty acid transporter FAT1	Saccharomyces cerevisiae S288C	0-4
10880966-14	2000	Fat1p or FATP also restored wild-type levels of beta-oxidation of exogenous long-chain fatty acids.	long-chain fatty acids	76-98	solute carrier family 27 (fatty acid transporter), member 1	Mus musculus	9-13
10455061-1	1999	Heart-type fatty acid binding protein (H-FABP), abundantly expressed in cardiac myocytes, has been postulated to facilitate the cardiac uptake of long-chain fatty acids (LCFAs) and to promote their intracellular trafficking to sites of metabolic conversion.	long-chain fatty acids	146-168	fatty acid binding protein 3, muscle and heart	Mus musculus	0-37
10976758-1	2000	Studies show that uptake of long-chain fatty acids (LCFA) across the plasma membranes (PM) may occur partly via a carrier-mediated process and that the plasma membrane fatty acid-binding protein (FABP(PM)) may be a component of this system.	long-chain fatty acids	28-50	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	196-204
10856718-9	2000	A third example, the ABC transporter involved in the import of long-chain fatty acids into peroxisomes, is discussed in the chapter by Hettema and Tabak in this volume.	long-chain fatty acids	63-85	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	21-24
10623894-0	2000	Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids.	long-chain fatty acids	100-122	perilipin 2	Homo sapiens	15-54
10623894-0	2000	Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids.	long-chain fatty acids	100-122	perilipin 2	Homo sapiens	56-60
10623894-2	2000	Recent experiments have demonstrated that ADRP is a fatty acid binding protein that specifically facilitates the uptake of long-chain fatty acids.	long-chain fatty acids	123-145	perilipin 2	Homo sapiens	42-46
10623894-7	2000	Comparison of the effect of several fatty acids with varying carbon chain lengths indicated that long-chain fatty acids were active in stimulating ADRP, whereas short-chain fatty acids such as caproate and 2-bromooctanoate had no effect.	long-chain fatty acids	97-119	perilipin 2	Homo sapiens	147-151
10593663-1	1999	Liver cytosolic fatty acid binding protein (FABP) represents the intracellular equivalent to extracellular serum albumin, participating in the intracellular transport of long-chain fatty acids.	long-chain fatty acids	170-192	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	16-42
10593663-1	1999	Liver cytosolic fatty acid binding protein (FABP) represents the intracellular equivalent to extracellular serum albumin, participating in the intracellular transport of long-chain fatty acids.	long-chain fatty acids	170-192	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	44-48
10582655-4	1999	On the other hand, BCL-2 prevented apoptosis induced by these long-chain fatty acids, where as n-3 fatty acids suppressed ras expression leading to suppression of development of overt neoplasia.	long-chain fatty acids	62-84	BCL2 apoptosis regulator	Homo sapiens	19-24
10582655-7	1999	Based on these results, it is suggested that long-chain fatty acids induce apoptosis by enhancing lipid peroxidation, suppressing BCL-2 expression possibly by phosphorylation and augmentation of P450 activity.	long-chain fatty acids	45-67	BCL2 apoptosis regulator	Homo sapiens	130-135
10769045-1	2000	Animal fatty acid synthase (FAS) is a homodimer protein which synthesizes long-chain fatty acids and is rich in liver, brain, breast, and lung.	long-chain fatty acids	74-96	fatty acid synthase	Homo sapiens	7-26
10823577-1	2000	Myelin proteolipid protein (PLP) is modified after translation by the attachment of long-chain fatty acids to several cysteine residues.	long-chain fatty acids	84-106	proteolipid protein 1	Rattus norvegicus	0-32
10548543-6	1999	The 78 kDa expressed LACS5 protein used the long-chain fatty acids palmitic acid, oleic acid and arachidonic acid as substrates.	long-chain fatty acids	44-66	acyl-CoA synthetase long chain family member 5	Homo sapiens	21-26
10551832-3	1999	The dysfunction of ALDP is responsible for X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder in which saturated very long-chain fatty acids accumulate because of their impaired peroxisomal beta-oxidation.	long-chain fatty acids	135-157	ATP binding cassette subfamily D member 1	Homo sapiens	19-23
10464295-2	1999	We reported previously that long-chain fatty acids are potent inhibitors of mammalian DNA polymerase beta.	long-chain fatty acids	28-50	DNA polymerase beta	Homo sapiens	86-105
10455061-1	1999	Heart-type fatty acid binding protein (H-FABP), abundantly expressed in cardiac myocytes, has been postulated to facilitate the cardiac uptake of long-chain fatty acids (LCFAs) and to promote their intracellular trafficking to sites of metabolic conversion.	long-chain fatty acids	146-168	fatty acid binding protein 3, muscle and heart	Mus musculus	39-45
10426378-9	1999	Since long-chain fatty acids activate PPAR-alpha endogenously, increased levels of these compounds in starvation and diabetes may signal increased expression of PDK4 in skeletal muscle.	long-chain fatty acids	6-28	peroxisome proliferator activated receptor alpha	Rattus norvegicus	38-48
10426378-9	1999	Since long-chain fatty acids activate PPAR-alpha endogenously, increased levels of these compounds in starvation and diabetes may signal increased expression of PDK4 in skeletal muscle.	long-chain fatty acids	6-28	pyruvate dehydrogenase kinase 4	Rattus norvegicus	161-165
10403814-3	1999	Long-chain fatty acids and eicosanoids were even more potent ligands for human PPARalpha than the hitherto most potent PPARalpha ligand WY-14,643.	long-chain fatty acids	0-22	peroxisome proliferator activated receptor alpha	Homo sapiens	79-88
10331656-3	1999	ALBP/aP2 and KLBP exhibit similar binding affinities for most long-chain fatty acids; however, ALBP/aP2 exhibits a two to three-fold increased affinity for myristic, palmitic, oleic and linoleic acids, the predominant fatty acids of adipocytes.	long-chain fatty acids	62-84	fatty acid binding protein 4	Homo sapiens	0-8
10333485-1	1999	Carnitine palmitoyltransferase (CPT)-I catalyses the transfer of long-chain fatty acids from CoA to carnitine for translocation across the mitochondrial inner membrane.	long-chain fatty acids	65-87	carnitine palmitoyltransferase 1A	Rattus norvegicus	0-38
10380116-1	1999	The aim of the present study was to investigate the hepatic regulation and beta-oxidation of long-chain fatty acids in peroxisomes and mitochondria, after 3-thia- tetradecylthioacetic acid (C14-S-acetic acid) treatment.	long-chain fatty acids	93-115	anti-Mullerian hormone receptor type 2	Rattus norvegicus	190-193
9895283-1	1999	The rat membrane protein fatty acid translocase (FAT), which shows sequence similarity to human CD36 (a membrane protein supposedly involved in a variety of membrane processes), is implicated in the transport of long-chain fatty acids across cellular membranes.	long-chain fatty acids	212-234	CD36 molecule	Rattus norvegicus	25-47
9895283-1	1999	The rat membrane protein fatty acid translocase (FAT), which shows sequence similarity to human CD36 (a membrane protein supposedly involved in a variety of membrane processes), is implicated in the transport of long-chain fatty acids across cellular membranes.	long-chain fatty acids	212-234	CD36 molecule	Rattus norvegicus	49-52
10331653-1	1999	An adipocyte membrane glycoprotein, FAT, homologous to CD36, has been implicated in the binding/transport of long-chain fatty acids.	long-chain fatty acids	109-131	CD36 molecule	Mus musculus	36-39
10331653-1	1999	An adipocyte membrane glycoprotein, FAT, homologous to CD36, has been implicated in the binding/transport of long-chain fatty acids.	long-chain fatty acids	109-131	CD36 molecule	Mus musculus	55-59
10231541-1	1999	To better understand the mechanism by which fatty acids bind to and dissociate from the binding cavities of fatty acid binding proteins (FABPs), we constructed 31 single amino acid mutants of the intestinal FABP (I-FABP) and determined the rate constants for binding and dissociation, primarily for long-chain fatty acids (FA).	long-chain fatty acids	299-321	fatty acid binding protein 2	Homo sapiens	213-219
10234607-2	1999	Current dietary management of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD; long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxido-reductase, EC 1.1.1.211) deficiency (LCHADD) is based on avoiding fasting, and minimizing energy production from long-chain fatty acids.	long-chain fatty acids	238-260	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	30-72
10234607-2	1999	Current dietary management of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD; long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxido-reductase, EC 1.1.1.211) deficiency (LCHADD) is based on avoiding fasting, and minimizing energy production from long-chain fatty acids.	long-chain fatty acids	238-260	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	119-134
10331667-1	1999	Long-chain fatty acids (LCFA) are the major energy substrate for heart and their oxidation is important for achieving maximal cardiac work.	long-chain fatty acids	0-22	LCFA	Bos taurus	24-28
9765271-1	1998	Fatty acid transport protein (FATP) was identified by expression cloning strategies (Schaffer, J. E., and Lodish, H. F. (1994) Cell 79, 427-436) and shown by transfection analysis to catalyze the transfer of long-chain fatty acids across the plasma membrane of cells.	long-chain fatty acids	208-230	solute carrier family 27 (fatty acid transporter), member 1	Mus musculus	0-28
9972874-1	1999	The hydrophobic myelin proteolipid protein (PLP) contains covalently bound long-chain fatty acids which are attached to intracellular cysteine residues via thioester linkages.	long-chain fatty acids	75-97	proteolipid protein 1	Homo sapiens	16-42
9972874-1	1999	The hydrophobic myelin proteolipid protein (PLP) contains covalently bound long-chain fatty acids which are attached to intracellular cysteine residues via thioester linkages.	long-chain fatty acids	75-97	proteolipid protein 1	Homo sapiens	44-47
9765271-1	1998	Fatty acid transport protein (FATP) was identified by expression cloning strategies (Schaffer, J. E., and Lodish, H. F. (1994) Cell 79, 427-436) and shown by transfection analysis to catalyze the transfer of long-chain fatty acids across the plasma membrane of cells.	long-chain fatty acids	208-230	solute carrier family 27 (fatty acid transporter), member 1	Mus musculus	30-34
9683528-1	1998	We report that Ex-FABP, an extracellular protein belonging to the lipocalin family and involved in the extracellular transport of long-chain fatty acids, is expressed in the forming myotubes both in vivo and in vitro.	long-chain fatty acids	130-152	extracellular fatty acid-binding protein	Gallus gallus	15-22
9772126-9	1998	These results suggest that the dioxygenase and CRBP (II) are regulated by the same mechanism involving long-chain fatty acids and their metabolites.	long-chain fatty acids	103-125	retinol binding protein 2	Rattus norvegicus	47-56
9726988-9	1998	These results demonstrate that long-chain fatty acids regulate the transcription of a gene encoding a pivotal enzyme in the mitochondrial fatty acid uptake pathway in cardiac myocytes and define a role for PPARalpha in the control of myocardial lipid metabolism.	long-chain fatty acids	31-53	peroxisome proliferator activated receptor alpha	Mus musculus	206-215
9788250-1	1998	Fatty acid translocase (FAT/CD36) is a membrane protein putatively involved in the transmembrane transport of long-chain fatty acids.	long-chain fatty acids	110-132	CD36 molecule	Rattus norvegicus	0-22
9788250-1	1998	Fatty acid translocase (FAT/CD36) is a membrane protein putatively involved in the transmembrane transport of long-chain fatty acids.	long-chain fatty acids	110-132	CD36 molecule	Rattus norvegicus	24-27
9721185-1	1998	The protonophoric (uncoupling) action of various long-chain fatty acids and their derivatives in mitochondria was investigated as related to their ability for rapid transbilayer movement in the inner mitochondrial membrane (flip-flop) and interaction with the ADP/ATP carrier (AAC).	long-chain fatty acids	49-71	WD and tetratricopeptide repeats 1	Homo sapiens	260-275
9548258-3	1998	Here we show that long-chain fatty acids directly modulate the transcriptional activity of HNF-4alpha by binding as their acyl-CoA thioesters to the ligand-binding domain of HNF-4alpha.	long-chain fatty acids	18-40	hepatocyte nuclear factor 4 alpha	Homo sapiens	91-101
9660783-2	1998	Very long-chain fatty acids, which accumulate in tissues of patients with X-linked adrenoleukodystrophy, are activated by very long-chain acyl-CoA synthetase (VLCS) normally found in peroxisomes and microsomes.	long-chain fatty acids	5-27	solute carrier family 27 member 2	Homo sapiens	122-157
9660783-2	1998	Very long-chain fatty acids, which accumulate in tissues of patients with X-linked adrenoleukodystrophy, are activated by very long-chain acyl-CoA synthetase (VLCS) normally found in peroxisomes and microsomes.	long-chain fatty acids	5-27	solute carrier family 27 member 2	Homo sapiens	159-163
9660783-8	1998	FAT1 deletion strains grown on either dextrose or oleic acid medium accumulated very long-chain fatty acids.	long-chain fatty acids	85-107	long-chain fatty acid transporter FAT1	Saccharomyces cerevisiae S288C	0-4
9607414-1	1998	Adrenoleukodystrophy (ALD) is a demyelinating disease of the central nervous system that results from a genetic deficiency of ALDP, an ABC protein involved in the transport of very long-chain fatty acids (VLCFAs).	long-chain fatty acids	181-203	ATP binding cassette subfamily D member 1	Homo sapiens	126-130
9607414-1	1998	Adrenoleukodystrophy (ALD) is a demyelinating disease of the central nervous system that results from a genetic deficiency of ALDP, an ABC protein involved in the transport of very long-chain fatty acids (VLCFAs).	long-chain fatty acids	181-203	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	135-138
9610770-1	1998	The binding of monoacylglycerides of long-chain fatty acids to human serum albumin has been examined using monooleoylglycerol as the ligand.	long-chain fatty acids	37-59	albumin	Homo sapiens	69-82
9604863-14	1998	Long-chain fatty acids (LCFAs), but not medium-chain fatty acids, induced the accumulation of Glc-6-Pase mRNA and the stabilization of the transcript.	long-chain fatty acids	0-22	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	94-104
9548258-3	1998	Here we show that long-chain fatty acids directly modulate the transcriptional activity of HNF-4alpha by binding as their acyl-CoA thioesters to the ligand-binding domain of HNF-4alpha.	long-chain fatty acids	18-40	hepatocyte nuclear factor 4 alpha	Homo sapiens	174-184
9482947-2	1998	In this study we used the whole-cell voltage-clamp technique to assess the effects of dietary, free long-chain fatty acids on the Na+ current (INa,alpha) in human embryonic kidney (HEK293t) cells transfected with the alpha-subunit of the human cardiac Na+ channel (hH1alpha).	long-chain fatty acids	100-122	internexin neuronal intermediate filament protein alpha	Homo sapiens	143-152
9204553-1	1997	The human intestinal fatty acid binding protein (I-FABP) is a small (131 amino acids) protein which binds dietary long-chain fatty acids in the cytosol of enterocytes.	long-chain fatty acids	114-136	fatty acid binding protein 2	Homo sapiens	10-47
9501266-1	1998	Deficiency of enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase (peroxisomal bifunctional enzyme), one of the enzymes of the peroxisomal beta-oxidation system, leads to clinical manifestations resembling Zellweger syndrome with hypotonia, psychomotor delay, hepatomegaly, typical facial appearance and accumulation of very long-chain fatty acids.	long-chain fatty acids	326-348	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	14-66
9501266-1	1998	Deficiency of enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase (peroxisomal bifunctional enzyme), one of the enzymes of the peroxisomal beta-oxidation system, leads to clinical manifestations resembling Zellweger syndrome with hypotonia, psychomotor delay, hepatomegaly, typical facial appearance and accumulation of very long-chain fatty acids.	long-chain fatty acids	326-348	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	68-99
9498103-1	1998	Very-long-chain acyl-CoA dehydrogenase (VLCAD) is an enzyme catalyzing the dehydrogenation of long-chain fatty acids in the first step of mitochondrial fatty acid oxidation.	long-chain fatty acids	94-116	acyl-CoA dehydrogenase very long chain	Homo sapiens	0-38
9498103-1	1998	Very-long-chain acyl-CoA dehydrogenase (VLCAD) is an enzyme catalyzing the dehydrogenation of long-chain fatty acids in the first step of mitochondrial fatty acid oxidation.	long-chain fatty acids	94-116	acyl-CoA dehydrogenase very long chain	Homo sapiens	40-45
9245824-7	1997	Competition experiments showed specificity of the mediated transport component for long-chain fatty acids (> C10).	long-chain fatty acids	83-105	homeobox C10	Homo sapiens	112-115
9191096-5	1997	Because of the high expression of FATP mRNA in the embryonic ventricular zone and the postnatal cerebellar cortical neurons in parallel to the gene expression for fatty acid binding protein (FABP) which we have recently reported, co-operated involvement of FATP and FABP in the active uptake of long-chain fatty acids is plausible in these cells.	long-chain fatty acids	295-317	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	163-189
9191096-5	1997	Because of the high expression of FATP mRNA in the embryonic ventricular zone and the postnatal cerebellar cortical neurons in parallel to the gene expression for fatty acid binding protein (FABP) which we have recently reported, co-operated involvement of FATP and FABP in the active uptake of long-chain fatty acids is plausible in these cells.	long-chain fatty acids	295-317	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	191-195
9191096-5	1997	Because of the high expression of FATP mRNA in the embryonic ventricular zone and the postnatal cerebellar cortical neurons in parallel to the gene expression for fatty acid binding protein (FABP) which we have recently reported, co-operated involvement of FATP and FABP in the active uptake of long-chain fatty acids is plausible in these cells.	long-chain fatty acids	295-317	CD36 molecule	Rattus norvegicus	257-261
9179548-2	1997	Threonine encoding allele in codon 54 of the I-FABP gene has been suggested as regulating the absorption of long-chain fatty acids.	long-chain fatty acids	108-130	fatty acid binding protein 2	Homo sapiens	45-51
9356448-4	1997	Adding equivalent amounts of TRX-hFAS-dI and TRX-hFAS-dII-III to a reaction mixture containing acetyl-CoA, malonyl-CoA, and NADPH resulted in the synthesis of long-chain fatty acids.	long-chain fatty acids	159-181	thioredoxin	Homo sapiens	29-32
9356448-4	1997	Adding equivalent amounts of TRX-hFAS-dI and TRX-hFAS-dII-III to a reaction mixture containing acetyl-CoA, malonyl-CoA, and NADPH resulted in the synthesis of long-chain fatty acids.	long-chain fatty acids	159-181	thioredoxin	Homo sapiens	45-48
9344464-2	1997	Carnitine palmitoyltransferase I (CPT-I) catalyzes the first reaction in the transport of long-chain fatty acids from the cytoplasm to the mitochondrion, a rate-limiting step in beta-oxidation.	long-chain fatty acids	90-112	carnitine palmitoyltransferase 1B	Homo sapiens	34-39
9397406-1	1997	Although it was recently recognized that sterol carrier protein-2 (SCP-2) interacts with fatty acids, little is known regarding the specificity of SCP-2 for long-chain fatty acids or branched-chain fatty-acid-like molecules.	long-chain fatty acids	157-179	sterol carrier protein 2	Homo sapiens	147-152
9373766-3	1997	Two common genetic variants, A54 and T54, of the intestinal fatty acid-binding protein gene (FABP2) have different in vitro binding affinities for long-chain fatty acids.	long-chain fatty acids	147-169	fatty acid binding protein 2	Homo sapiens	93-98
9312173-3	1997	Since long-chain fatty acids (FFA), like IL-1beta, upregulate inducible nitric oxide synthase and enhance NO generation in islets, it seemed possible that islets might be protected from IL-1beta-induced damage by lowering their lipid content.	long-chain fatty acids	6-28	interleukin 1 beta	Rattus norvegicus	186-194
9342538-8	1997	Insulin and glucocorticoids increase leptin expression, whereas catecholamines, via beta-adrenergic receptors and cAMP, and long-chain fatty acids (and thiazolidinediones), via PPARy, inhibit leptin expression.	long-chain fatty acids	124-146	insulin	Homo sapiens	0-7
9342538-8	1997	Insulin and glucocorticoids increase leptin expression, whereas catecholamines, via beta-adrenergic receptors and cAMP, and long-chain fatty acids (and thiazolidinediones), via PPARy, inhibit leptin expression.	long-chain fatty acids	124-146	leptin	Homo sapiens	192-198
9313156-0	1997	Effect of recombinant bovine somatotropin and calcium salts of long-chain fatty acids on milk from Italian buffalo.	long-chain fatty acids	63-85	Weaning weight-maternal milk	Bos taurus	89-93
9313156-3	1997	Administration of bST and Ca salts of long-chain fatty acids increased milk production.	long-chain fatty acids	38-60	Weaning weight-maternal milk	Bos taurus	71-75
9313156-7	1997	Milk protein percentage was decreased by the addition of Ca salts of long-chain fatty acids.	long-chain fatty acids	69-91	Weaning weight-maternal milk	Bos taurus	0-4
9313156-9	1997	Body condition score was lowered by bST administration, but the addition of Ca salts of long-chain fatty acids reduced body condition loss in buffalo that were treated with somatotropin.	long-chain fatty acids	88-110	somatotropin	Bos taurus	173-185
9277406-4	1997	The L-FABP induction was only found with long-chain fatty acids, with the nonmetabolizable, substituted fatty acid alpha-bromopalmitate being far more active.	long-chain fatty acids	41-63	fatty acid binding protein 1, liver	Mus musculus	4-10
9277406-5	1997	A hormonally mediated effect is unlikely because long-chain fatty acids induced L-FABP mRNA in the Caco-2 cell line cultured in serum-free medium.	long-chain fatty acids	49-71	fatty acid binding protein 1	Homo sapiens	80-86
9277406-6	1997	Therefore, long-chain fatty acids are strong inducers of L-FABP gene expression in the small intestine.	long-chain fatty acids	11-33	fatty acid binding protein 1, liver	Mus musculus	57-63
9173869-1	1997	Two important factors that determine the flux of hepatic beta-oxidation of long-chain fatty acids are the availability of fatty acid and the activity of carnitine palmitoyltransferase I (CPT I).	long-chain fatty acids	75-97	carnitine palmitoyltransferase 1B	Rattus norvegicus	153-185
9173869-1	1997	Two important factors that determine the flux of hepatic beta-oxidation of long-chain fatty acids are the availability of fatty acid and the activity of carnitine palmitoyltransferase I (CPT I).	long-chain fatty acids	75-97	carnitine palmitoyltransferase 1B	Rattus norvegicus	187-192
9204553-1	1997	The human intestinal fatty acid binding protein (I-FABP) is a small (131 amino acids) protein which binds dietary long-chain fatty acids in the cytosol of enterocytes.	long-chain fatty acids	114-136	fatty acid binding protein 2	Homo sapiens	49-55
9032094-0	1997	Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1.	long-chain fatty acids	0-22	insulin 1	Rattus norvegicus	103-108
8985169-7	1996	A study of the specificity of fatty acids revealed that long-chain fatty acids of more than 16 carbons chain length had a suppressive effect on the CPS mRNA level induced by dexamethasone and that the presence of double bonds enhanced the effect.	long-chain fatty acids	56-78	carbamoyl-phosphate synthetase 1	Mus musculus	148-151
9013572-1	1997	To identify cell death-induced genes, we employed a subtractive hybridization approach and isolated a cDNA encoding a mouse homolog of carnitine palmitoyltransferase I (CPT I), an enzyme that resides at the outer mitochondrial membrane and facilitates passage of long-chain fatty acids into mitochondria for beta-oxidation.	long-chain fatty acids	263-285	carnitine palmitoyltransferase 1b, muscle	Mus musculus	135-167
9013572-1	1997	To identify cell death-induced genes, we employed a subtractive hybridization approach and isolated a cDNA encoding a mouse homolog of carnitine palmitoyltransferase I (CPT I), an enzyme that resides at the outer mitochondrial membrane and facilitates passage of long-chain fatty acids into mitochondria for beta-oxidation.	long-chain fatty acids	263-285	carnitine palmitoyltransferase 1b, muscle	Mus musculus	169-174
8993549-2	1996	PPAR alpha signaling is modulated by long-chain fatty acids, whereas PPAR gamma ligands are potent antidiabetic agents.	long-chain fatty acids	37-59	peroxisome proliferator activated receptor alpha	Homo sapiens	0-10
9049433-1	1997	Previous studies have shown that fatty acid ethyl ester synthase (FAEES) which catalyzes the formation of ethyl or 2-chloroethyl esters of long-chain fatty acids is localized in the microsomal fraction of rat liver.	long-chain fatty acids	139-161	carboxylesterase 1D	Rattus norvegicus	33-64
9049433-1	1997	Previous studies have shown that fatty acid ethyl ester synthase (FAEES) which catalyzes the formation of ethyl or 2-chloroethyl esters of long-chain fatty acids is localized in the microsomal fraction of rat liver.	long-chain fatty acids	139-161	carboxylesterase 1D	Rattus norvegicus	66-71
9240920-3	1997	ACC-alpha is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC-beta is believed to control mitochondrial fatty acid oxidation.	long-chain fatty acids	59-81	acetyl-CoA carboxylase alpha	Homo sapiens	0-9
8876158-1	1996	Acetyl-CoA carboxylase, which has a molecular mass of 265 kDa (ACC-alpha), catalyzes the rate-limiting step in the biosynthesis of long-chain fatty acids.	long-chain fatty acids	131-153	acetyl-CoA carboxylase alpha	Homo sapiens	63-72
8912685-0	1996	Up-regulation of the expression of the gene for liver fatty acid-binding protein by long-chain fatty acids.	long-chain fatty acids	84-106	fatty acid binding protein 1	Rattus norvegicus	48-80
8912685-9	1996	Therefore long-chain fatty acids are strong inducers of L-FABP gene expression.	long-chain fatty acids	10-32	fatty acid binding protein 1	Rattus norvegicus	56-62
8944749-0	1996	Covalent complexes between serum albumin and 7-hydroxycoumarin-4-acetic acid: synthesis and applications in the spectrophotometric detection of long-chain fatty acids.	long-chain fatty acids	144-166	albumin	Homo sapiens	27-40
8914941-4	1996	Significant increases in lymph lipid (triglyceride, phospholipid) and apo A-IV output were observed in response to long-chain fatty acids (14:0, 18:0, 18:1, 18:2, 20:4) or triolein; short- or medium-chain fatty acids (4:0, 8:0, 12:0) or tributyrin or tricaprylin produced no significant increase in lymph lipid output above basal levels.	long-chain fatty acids	115-137	apolipoprotein A4	Rattus norvegicus	70-78
8694909-0	1996	Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homolog.	long-chain fatty acids	22-44	CD36 molecule	Rattus norvegicus	57-60
8694909-1	1996	Transport of long-chain fatty acids into rat adipocytes was previously shown to be inhibited by the reactive derivative sulfosuccinimidyl oleate consequent to its binding to a membrane protein FAT, which is homologous to CD36.	long-chain fatty acids	13-35	CD36 molecule	Rattus norvegicus	193-196
8615793-1	1996	Rat liver fatty acid-binding protein (FABP) is able to accommodate a wide range of non-polar anions in addition to long-chain fatty acids.	long-chain fatty acids	115-137	fatty acid binding protein 2	Rattus norvegicus	38-42
8670886-0	1996	The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae.	long-chain fatty acids	70-92	Pat1p	Saccharomyces cerevisiae S288C	29-33
8670886-0	1996	The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae.	long-chain fatty acids	70-92	ATP-binding cassette long-chain fatty acid transporter PXA1	Saccharomyces cerevisiae S288C	38-42
8670886-5	1996	On the other hand, long-chain fatty acids are imported from the cytosolic pool of activated long-chain fatty acids via Pat1p and Pat2p, peroxisomal membrane proteins belonging to the ATP binding cassette transporter superfamily.	long-chain fatty acids	19-41	Pat1p	Saccharomyces cerevisiae S288C	119-124
8670886-5	1996	On the other hand, long-chain fatty acids are imported from the cytosolic pool of activated long-chain fatty acids via Pat1p and Pat2p, peroxisomal membrane proteins belonging to the ATP binding cassette transporter superfamily.	long-chain fatty acids	19-41	ATP-binding cassette long-chain fatty acid transporter PXA1	Saccharomyces cerevisiae S288C	129-134
8670886-5	1996	On the other hand, long-chain fatty acids are imported from the cytosolic pool of activated long-chain fatty acids via Pat1p and Pat2p, peroxisomal membrane proteins belonging to the ATP binding cassette transporter superfamily.	long-chain fatty acids	92-114	Pat1p	Saccharomyces cerevisiae S288C	119-124
8670886-5	1996	On the other hand, long-chain fatty acids are imported from the cytosolic pool of activated long-chain fatty acids via Pat1p and Pat2p, peroxisomal membrane proteins belonging to the ATP binding cassette transporter superfamily.	long-chain fatty acids	92-114	ATP-binding cassette long-chain fatty acid transporter PXA1	Saccharomyces cerevisiae S288C	129-134
8631905-1	1996	The human intestinal fatty acid binding protein (IFABP) binds long-chain fatty acids in vitro, but its intracellular function has remained speculative.	long-chain fatty acids	62-84	fatty acid binding protein 2	Homo sapiens	10-47
8631905-1	1996	The human intestinal fatty acid binding protein (IFABP) binds long-chain fatty acids in vitro, but its intracellular function has remained speculative.	long-chain fatty acids	62-84	fatty acid binding protein 2	Homo sapiens	49-54
8631905-2	1996	A polymorphism in the gene that encodes IFABP results in an alanine (Ala54) to threonine (Thr54) substitution at codon 54 that alters the in vitro binding affinity of the protein for long-chain fatty acids.	long-chain fatty acids	183-205	fatty acid binding protein 2	Homo sapiens	40-45
8631905-4	1996	We found that Caco-2 cells expressing Thr54 IFABP transport long-chain fatty acids and secrete triglycerides to a greater degree than Caco-2 cells expressing Ala54 IFABP.	long-chain fatty acids	60-82	fatty acid binding protein 2	Homo sapiens	44-49
8631905-5	1996	These results provide the first demonstration that IFABP participates in the intracellular transport of long-chain fatty acids.	long-chain fatty acids	104-126	fatty acid binding protein 2	Homo sapiens	51-56
8872718-8	1996	Milk fat from cows fed soybeans or sunflower seeds contained higher concentrations of unsaturated fatty acids and long-chain fatty acids than did milk fat from cows fed the control diet.	long-chain fatty acids	114-136	Weaning weight-maternal milk	Bos taurus	0-4
8797095-2	1996	In this paper, we report that lipogenesis in primary cultured rat hepatocytes treated with 10 ng/ml of recombinant human HGF (rhHGF) for 24 h was stimulated, as measured by the incorporation of 3H2O into long-chain fatty acids, to more than twice as much as the control.	long-chain fatty acids	204-226	hepatocyte growth factor	Homo sapiens	121-124
8610095-1	1996	An adipocyte membrane glycoprotein, (FAT), homologous to human CD36, has been previously implicated in the binding/transport of long-chain fatty acids.	long-chain fatty acids	128-150	CD36 molecule	Homo sapiens	37-40
8610095-12	1996	The data support the interpretation that FAT/CD36 functions as a high-affinity membrane receptor/transporter for long-chain fatty acids.	long-chain fatty acids	113-135	CD36 molecule	Homo sapiens	41-44
8830055-8	1996	Very-long-chain acyl-CoA synthetase was active toward long- and very-long-chain fatty acids, but more active toward very-long-chain fatty acids compared with long-chain acyl-CoA synthetase.	long-chain fatty acids	69-91	solute carrier family 27 member 2	Rattus norvegicus	0-35
7643237-6	1995	Transcripts of both retinoid X receptor alpha and peroxisome proliferator-activated receptor (PPAR), which are thought to interact as a heterodimer with the cis-element located in the CRBP II promoter and to be activated by 9-cis retinoic acid and long-chain fatty acids, respectively, were constitutively expressed in the rat jejunum.	long-chain fatty acids	248-270	retinoid X receptor alpha	Rattus norvegicus	20-45
8631336-12	1996	Xenobiotic hypolipidemic peroxisome proliferators and native long-chain fatty acids seem to exploit the PPAR/PPRE transduction pathway used by prostacyclin.	long-chain fatty acids	61-83	peroxisome proliferator activated receptor alpha	Rattus norvegicus	104-108
21413269-1	1996	These genera are characterized by the presence of long-chain fatty acids, called mycolic aids, which have the following general structures in their cell walls: The side chains (R1 and R2) vary in length according to the genus; C60 to C90 in Mycobacterium; C40 to C56 in Nocardia.	long-chain fatty acids	50-72	CCR4-NOT transcription complex subunit 11	Homo sapiens	256-259
8554625-1	1995	Very-long-chain acyl-CoA dehydrogenase (VLCAD) is a major enzyme catalyzing long-chain fatty acids in the first step of mitochondrial beta-oxidation system.	long-chain fatty acids	76-98	acyl-CoA dehydrogenase very long chain	Homo sapiens	0-38
8554625-1	1995	Very-long-chain acyl-CoA dehydrogenase (VLCAD) is a major enzyme catalyzing long-chain fatty acids in the first step of mitochondrial beta-oxidation system.	long-chain fatty acids	76-98	acyl-CoA dehydrogenase very long chain	Homo sapiens	40-45
19245473-3	1995	Human neutrophil elastase (HNE) can be inhibited by long-chain fatty acids and their derivatives; it was therefore postulated that plant ceramides could be inhibitors of HNE.	long-chain fatty acids	52-74	elastase, neutrophil expressed	Homo sapiens	6-25
8892024-4	1996	The present study was undertaken as a first step towards elucidating a possible role for PKC in the pathogenesis of Zellweger syndrome, in which there are both perturbation of plasma membrane phospholipids and accumulation of very long-chain fatty acids.	long-chain fatty acids	231-253	proline rich transmembrane protein 2	Homo sapiens	89-92
7643237-6	1995	Transcripts of both retinoid X receptor alpha and peroxisome proliferator-activated receptor (PPAR), which are thought to interact as a heterodimer with the cis-element located in the CRBP II promoter and to be activated by 9-cis retinoic acid and long-chain fatty acids, respectively, were constitutively expressed in the rat jejunum.	long-chain fatty acids	248-270	peroxisome proliferator activated receptor alpha	Rattus norvegicus	50-92
7643237-6	1995	Transcripts of both retinoid X receptor alpha and peroxisome proliferator-activated receptor (PPAR), which are thought to interact as a heterodimer with the cis-element located in the CRBP II promoter and to be activated by 9-cis retinoic acid and long-chain fatty acids, respectively, were constitutively expressed in the rat jejunum.	long-chain fatty acids	248-270	peroxisome proliferator activated receptor alpha	Rattus norvegicus	94-98
7643237-6	1995	Transcripts of both retinoid X receptor alpha and peroxisome proliferator-activated receptor (PPAR), which are thought to interact as a heterodimer with the cis-element located in the CRBP II promoter and to be activated by 9-cis retinoic acid and long-chain fatty acids, respectively, were constitutively expressed in the rat jejunum.	long-chain fatty acids	248-270	retinol binding protein 2	Rattus norvegicus	184-191
7864868-1	1995	A membrane protein (FAT) homologous to CD36 has recently been implicated in the binding and transport of long-chain fatty acids (FA).	long-chain fatty acids	105-127	CD36 molecule	Rattus norvegicus	20-23
7755560-0	1995	A direct role for serum albumin in the cellular uptake of long-chain fatty acids.	long-chain fatty acids	58-80	albumin	Homo sapiens	18-31
7755560-2	1995	The majority of long-chain fatty acids circulating in plasma exist as complexes with serum albumin.	long-chain fatty acids	16-38	albumin	Homo sapiens	85-98
7755560-4	1995	The effect of serum albumin on the uptake of long-chain fatty acids was studied in 3T3-L1 adipocytes.	long-chain fatty acids	45-67	albumin	Homo sapiens	14-27
7755560-10	1995	These results indicate that the stimulatory effect of serum albumin on the rate of oleate uptake is due to a direct interaction of serum albumin with the cells and point to an involvement of albumin binding sites in the cell surface in the cellular uptake of long-chain fatty acids.	long-chain fatty acids	259-281	albumin	Homo sapiens	54-67
7755560-10	1995	These results indicate that the stimulatory effect of serum albumin on the rate of oleate uptake is due to a direct interaction of serum albumin with the cells and point to an involvement of albumin binding sites in the cell surface in the cellular uptake of long-chain fatty acids.	long-chain fatty acids	259-281	albumin	Homo sapiens	131-144
7552171-2	1995	As well as being the precursors of the triacylglycerols deposited as fat in adipose tissue, long-chain fatty acids are one class of agents that induce the differentiation of preadipocytes to adipocytes.	long-chain fatty acids	92-114	FAT atypical cadherin 1	Homo sapiens	69-72
7673524-6	1995	The magnitude of decrease in the percentage of medium-chain fatty acids in milk of cows infused with oil was similar to the magnitude of the increase in the long-chain fatty acids of milk.	long-chain fatty acids	157-179	Weaning weight-maternal milk	Bos taurus	183-187
7840673-11	1995	Based upon these results, we suggest that this long-chain acyl-ACP thioesterase may be a ubiquitous enzyme in plants which is involved in the synthesis of long-chain fatty acids.	long-chain fatty acids	155-177	Acyl-ACP thioesterase	Arabidopsis thaliana	58-79
7879864-8	1994	The HPLC analysis of the estrogens released following hydrolysis of the esters indicated that E2 beta was the main estrogen acylated by long-chain fatty acids in the fraction of lipoidal estrogens.	long-chain fatty acids	136-158	dihydrolipoamide branched chain transacylase E2	Bos taurus	94-101
1438299-0	1992	Induction of aP2 gene expression by nonmetabolized long-chain fatty acids.	long-chain fatty acids	51-73	fatty acid binding protein 4	Homo sapiens	13-16
8141397-1	1994	The effect of thermal acclimation on the activity of carnitine palmitoyltransferase I (CPT I), the rate-limiting enzyme for beta-oxidation of long-chain fatty acids, was determined in oxidative red muscle of striped bass (Morone saxatilis) acclimated at 5 or 25 degrees C. As observed in mammalian tissues, malonyl-CoA potently inhibited CPT I activity of mitochondria.	long-chain fatty acids	142-164	carnitine palmitoyltransferase 1B	Homo sapiens	87-92
8121293-0	1994	Long-chain fatty acids decrease lipoprotein lipase activity of cultured rat adipocyte precursors.	long-chain fatty acids	0-22	lipoprotein lipase	Rattus norvegicus	32-50
8399375-13	1993	In brown adipose tissue, the special thermogenic organ of mammals, long-chain fatty acids promote operation of the unique natural uncoupling protein, thermogenin.	long-chain fatty acids	67-89	uncoupling protein 1	Homo sapiens	150-161
8125532-8	1993	The rate of release of IgA into the intestinal lumen is stimulated by absorption of long-chain fatty acids possibly through the influence of locally released CCK, while the transport process of IgA into lymphatics is controlled by a different mechanism which is closely correlated with the intracellular formation and secretion of chylomicron.	long-chain fatty acids	84-106	cholecystokinin	Rattus norvegicus	158-161
7693843-1	1993	The adipocyte fatty acid-binding protein, aP2 or ALBP, is an abundant cytosolic protein postulated to function in binding and intracellular transport of long-chain fatty acids.	long-chain fatty acids	153-175	fatty acid binding protein 4	Rattus norvegicus	42-45
7693843-1	1993	The adipocyte fatty acid-binding protein, aP2 or ALBP, is an abundant cytosolic protein postulated to function in binding and intracellular transport of long-chain fatty acids.	long-chain fatty acids	153-175	fatty acid binding protein 4	Rattus norvegicus	49-53
7688729-15	1993	The data suggest that FAT and CD36 belong to a family of proteins that bind/transport long-chain fatty acids or function as regulators of these processes.	long-chain fatty acids	86-108	CD36 molecule	Rattus norvegicus	22-25
7827256-3	1994	As CPT-1 and CPT-2 are both required for the oxidation of long-chain fatty acids in mitochondria, it can be concluded that inhibition of fatty acid oxidation per se is not responsible for cell growth, but rather the accumulation of a metabolite, probably long-chain acylcoenzyme A. CPT-1 and CPT-2 inhibitors cause different metabolic changes in the heart.	long-chain fatty acids	58-80	carnitine palmitoyltransferase 2	Rattus norvegicus	13-18
8034667-10	1994	The cDNA expression in both rat hepatoma H4IIEC3 and McA-RH7777 enhanced about 3-fold mitochondrial beta-oxidation activity of long-chain fatty acids such as palmitic acid and stearic acid; hence, VLCAD is probably a rate-limiting enzyme in the long-chain fatty acid beta-oxidation system in these cell lines.	long-chain fatty acids	127-149	acyl-CoA dehydrogenase, very long chain	Rattus norvegicus	197-202
8186230-5	1994	These results suggest that the expression level of the CRBP II gene is not directly related to the RXR alpha expression, and that it might be modulated by long-chain fatty acids or their metabolites.	long-chain fatty acids	155-177	retinol binding protein 2	Rattus norvegicus	55-62
8262919-3	1993	Although both long-chain dicarboxylic fatty acids, which are poorly metabolized in hepatocytes, and non-beta-oxidizable fatty acid analogs induce peroxisomal beta-oxidation and liver fatty acid-binding protein (L-FABP) by a pretranslational mechanism, monocarboxylic long-chain fatty acids, which are rapidly esterified and oxidized, do not.	long-chain fatty acids	267-289	fatty acid binding protein 1	Homo sapiens	211-217
8262919-10	1993	These results provide support for a mechanism by which long-chain fatty acids or specific metabolites, including long-chain acyl-CoA esters and long-chain dicarboxylic acids, act as signals in the induction of P-450 4A1, peroxisomal beta-oxidation, and L-FABP under conditions in which long-chain fatty acids accumulate due to impaired entry into the mitochondrial beta-oxidation pathway.	long-chain fatty acids	55-77	fatty acid binding protein 1	Homo sapiens	253-259
8262919-10	1993	These results provide support for a mechanism by which long-chain fatty acids or specific metabolites, including long-chain acyl-CoA esters and long-chain dicarboxylic acids, act as signals in the induction of P-450 4A1, peroxisomal beta-oxidation, and L-FABP under conditions in which long-chain fatty acids accumulate due to impaired entry into the mitochondrial beta-oxidation pathway.	long-chain fatty acids	286-308	fatty acid binding protein 1	Homo sapiens	253-259
8238519-1	1993	A relationship between plasma membrane fatty acid binding protein (FABPpm), a putative membrane transporter for long-chain fatty acids, and the mitochondrial isoform of aspartate aminotransferase (m-AspAT) has been reported.	long-chain fatty acids	112-134	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	67-73
8238519-1	1993	A relationship between plasma membrane fatty acid binding protein (FABPpm), a putative membrane transporter for long-chain fatty acids, and the mitochondrial isoform of aspartate aminotransferase (m-AspAT) has been reported.	long-chain fatty acids	112-134	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	199-204
8218196-0	1993	Interactions of all-trans-retinol and long-chain fatty acids with interphotoreceptor retinoid-binding protein.	long-chain fatty acids	38-60	retinol binding protein 3	Homo sapiens	66-109
8218196-6	1993	Long-chain fatty acids were found in this study to displace all-trans-retinol from the stronger retinol-binding site on IRBP.	long-chain fatty acids	0-22	retinol binding protein 3	Homo sapiens	120-124
8499488-5	1993	In addition, PFDA and CPIB compete with long-chain fatty acids for binding to FABP but do not compete with long-chain acyl-CoA esters for binding to ACBP.	long-chain fatty acids	40-62	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	78-82
1295883-0	1992	Preferential activation of phospholipase A2 by low concentrations of phosphatidic acid with long-chain fatty acids in rabbit platelets.	long-chain fatty acids	92-114	phospholipase A2	Oryctolagus cuniculus	27-43
1438299-1	1992	Long-chain fatty acids (FA) have been shown to regulate expression of the gene for the adipocyte FA-binding protein aP2.	long-chain fatty acids	0-22	fatty acid binding protein 4	Homo sapiens	116-119
1322170-1	1992	Esterification of retinol (vitamin A alcohol) with long-chain fatty acids by lecithin-retinol acyltransferase (LRAT) is an important step in both the absorption and storage of vitamin A.	long-chain fatty acids	51-73	lecithin retinol acyltransferase	Homo sapiens	77-109
1420290-2	1992	Inhibition of the mitochondrial uptake of long-chain fatty acids was achieved by treating rats with 2-tetradecylglycidic acid (TDGA), a potent inhibitor of the overt form of carnitine palmitoyltransferase (CPT-I).	long-chain fatty acids	42-64	carnitine palmitoyltransferase 1B	Rattus norvegicus	206-211
1322170-1	1992	Esterification of retinol (vitamin A alcohol) with long-chain fatty acids by lecithin-retinol acyltransferase (LRAT) is an important step in both the absorption and storage of vitamin A.	long-chain fatty acids	51-73	lecithin retinol acyltransferase	Homo sapiens	111-115
1795060-5	1991	Bovine somatotropin may cause an increase in the relative amount of long-chain fatty acids, and the SCC is sometimes increased.	long-chain fatty acids	68-90	somatotropin	Bos taurus	7-19
1533971-0	1992	Inhibition of Zn(2+)-dependent ATPase in prostasome membrane by nonsaturated, long-chain fatty acids.	long-chain fatty acids	78-100	dynein axonemal heavy chain 8	Homo sapiens	31-37
1533971-4	1992	The restraining role of nonsaturated, long-chain fatty acids on sperm motility in human semen is discussed in terms of their established inhibitory action on prostasome ATPase systems.	long-chain fatty acids	38-60	dynein axonemal heavy chain 8	Homo sapiens	169-175
1999498-9	1991	As observed in the patient described herein, CPT II activity ought to be more reduced to induce an impaired oxidation of long-chain fatty acids in these tissues.	long-chain fatty acids	121-143	carnitine palmitoyltransferase 2	Homo sapiens	45-51
1753215-8	1991	Long-chain fatty acids (greater than or equal to C12) are able to activate the aP2 gene.	long-chain fatty acids	0-22	transcription factor AP-2, alpha	Mus musculus	79-82
2026168-0	1991	Binding of long-chain fatty acids to serum albumin in healthy humans.	long-chain fatty acids	11-33	albumin	Homo sapiens	37-50
1773450-4	1991	Again like spectrin, the alpha-actinin fragment contains multiple binding sites for long-chain fatty acids, as revealed by quenching of tryptophan fluorescence by 2-bromostearate (though not by 9(10)-bromostearate).	long-chain fatty acids	84-106	actinin alpha 1	Homo sapiens	25-38
1695508-1	1990	Myelin proteolipid protein (PLP) contains covalently bound long-chain fatty acids.	long-chain fatty acids	59-81	proteolipid protein 1	Bos taurus	0-32
2266958-3	1990	(b) What is the relationship between the acinar gradient of L-FABP and acinar gradients in the transport and metabolism of long-chain fatty acids?	long-chain fatty acids	123-145	fatty acid binding protein 1	Rattus norvegicus	60-66
2317197-0	1990	A continuous fluorescence displacement assay for the measurement of phospholipase A2 and other lipases that release long-chain fatty acids.	long-chain fatty acids	116-138	phospholipase A2 group IB	Rattus norvegicus	68-84
2317197-2	1990	A new continuous fluorescence assay for phospholipase A2 is described which involves the displacement of the highly fluorescent fatty-acid probe 11-(dansylamino)undecanoic acid from rat liver fatty-acid-binding protein by long-chain fatty acids released as a result of phospholipase A2-catalysed hydrolysis of phospholipids.	long-chain fatty acids	222-244	phospholipase A2 group IB	Rattus norvegicus	40-56
2317197-2	1990	A new continuous fluorescence assay for phospholipase A2 is described which involves the displacement of the highly fluorescent fatty-acid probe 11-(dansylamino)undecanoic acid from rat liver fatty-acid-binding protein by long-chain fatty acids released as a result of phospholipase A2-catalysed hydrolysis of phospholipids.	long-chain fatty acids	222-244	phospholipase A2 group IB	Rattus norvegicus	269-285
2301636-7	1990	CPT I participates in that control by regulating the partitioning of long-chain fatty acids between pathways of storage and intramitochondrial oxidation.	long-chain fatty acids	69-91	carnitine palmitoyltransferase 1B	Rattus norvegicus	0-5
2176647-5	1990	Results show that 1) long-chain fatty acids depress the synthesis of fatty acids, cholesterol, and sulphatide; and 2) the presence of long-chain, in contrast to short-chain, fatty acids in the culture medium lowers the activities of 2",3"-cyclic-nucleotide 3"-phosphodiesterase and glycerol 3-phosphate dehydrogenase and decreases the number of oligodendrocytes.	long-chain fatty acids	21-43	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	233-277
2176647-5	1990	Results show that 1) long-chain fatty acids depress the synthesis of fatty acids, cholesterol, and sulphatide; and 2) the presence of long-chain, in contrast to short-chain, fatty acids in the culture medium lowers the activities of 2",3"-cyclic-nucleotide 3"-phosphodiesterase and glycerol 3-phosphate dehydrogenase and decreases the number of oligodendrocytes.	long-chain fatty acids	21-43	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	282-316
34813948-1	2022	The long-chain acyl-CoA synthase1 (Acsl1) is a major enzyme that converts long-chain fatty acids to acyl-CoAs.	long-chain fatty acids	74-96	acyl-CoA synthetase long-chain family member 1	Mus musculus	35-40
34237158-4	2022	METHODS AND RESULTS: We provide evidence that RIP140 is modulated through a redox-dependent mechanism driven by very long-chain fatty acids (VLCFAs), the levels of which are increased in X-ALD.	long-chain fatty acids	117-139	nuclear receptor interacting protein 1	Mus musculus	46-52
34449874-3	2022	Fatty acid-binding protein 5 (FABP5) is a cellular chaperone of long-chain fatty acids that induce biological responses.	long-chain fatty acids	64-86	fatty acid binding protein 5, epidermal	Mus musculus	0-28
34449874-3	2022	Fatty acid-binding protein 5 (FABP5) is a cellular chaperone of long-chain fatty acids that induce biological responses.	long-chain fatty acids	64-86	fatty acid binding protein 5, epidermal	Mus musculus	30-35
34605573-7	2021	While the modulation of ROS-production seemed to be indirectly affected by miR-100 via Alox5-and Nox4-downregulation, we demonstrated that miR-100 induced a direct repression of the scavenger protein CD36 in murine hearts resulting in a decreased uptake of long-chain fatty acids and an alteration of mitochondrial respiratory function with an enhanced glycolytic state.	long-chain fatty acids	257-279	microRNA 100	Mus musculus	75-82
34617154-7	2021	By measuring the PageRank centrality of molecules in this module, we computationally evaluated the network-based importance of the 23 metabolites and demonstrated that the metabolism pathways of aromatic amino acids and long-chain fatty acids provided potential molecular targets of NSCLC (i.e., IL4l1 and ACOT2).	long-chain fatty acids	220-242	acyl-CoA thioesterase 2	Homo sapiens	306-311
34109887-7	2021	CONCLUSIONS: This carrier strategy for small molecule drugs is based on naturally evolved interactions between long-chain fatty acids (LCFAs) and Human Serum Albumin (HSA), demonstrated here for PTX.	long-chain fatty acids	111-133	albumin	Mus musculus	152-165
34716609-1	2021	X-linked adrenoleukodystrophy (X-ALD) is a phenotypically heterogeneous disorder involving defective peroxisomal beta-oxidation of very long-chain fatty acids (VLCFAs), due to mutation in the ABCD1 gene.	long-chain fatty acids	136-158	ATP binding cassette subfamily D member 1	Homo sapiens	192-197
34605573-7	2021	While the modulation of ROS-production seemed to be indirectly affected by miR-100 via Alox5-and Nox4-downregulation, we demonstrated that miR-100 induced a direct repression of the scavenger protein CD36 in murine hearts resulting in a decreased uptake of long-chain fatty acids and an alteration of mitochondrial respiratory function with an enhanced glycolytic state.	long-chain fatty acids	257-279	microRNA 100	Mus musculus	139-146
34573356-6	2021	After target gene prediction, we found that ACSL3 was cis-targeted by lncRNA TCONS-00052400 and could activate the conversion of long-chain fatty acids.	long-chain fatty acids	129-151	acyl-CoA synthetase long chain family member 3	Sus scrofa	44-49
34506728-3	2022	Chemical biological analysis of its photoaffinity probe identified the hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha (HADHA), a mitochondrial enzyme that catalyzes beta-oxidation of long-chain fatty acids, as its selective binding protein.	long-chain fatty acids	214-236	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	150-155
35144186-1	2022	The long-chain fatty acid receptor FFAR4 is the main G-protein-coupled receptor in the body for detecting long-chain fatty acids.	long-chain fatty acids	106-128	free fatty acid receptor 4	Homo sapiens	35-40
34085843-3	2021	Cardiac knockout of carnitine palmitoyltransferase 2 (Cpt2M-/-) in mice hinders cardiomyocyte bioenergetic metabolism of long-chain fatty acids, and leads to progressive cardiac hypertrophy and heart failure.	long-chain fatty acids	121-143	carnitine palmitoyltransferase 2	Mus musculus	20-52
35001637-7	2022	Many kinds of natural products promote white adipose tissue browning, such as alkaloids, flavonoids, terpenoids, and long-chain fatty acids, which can also ameliorate metabolic disorders including obesity, insulin resistance and diabetes.	long-chain fatty acids	117-139	insulin	Homo sapiens	206-213
35588628-2	2022	FFAR4 is highly expressed in the intestine and acts primarily as the receptor of long-chain fatty acids, which are major components of the human diet.	long-chain fatty acids	81-103	free fatty acid receptor 4	Homo sapiens	0-5
35179151-2	2022	We have found that CYP152A1 possesses catalase activity, which competes with the hydroxylation of long-chain fatty acids, the oxidation of non-native substrates, and haem degradation.	long-chain fatty acids	98-120	catalase	Homo sapiens	38-46
35624726-1	2022	The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance.	long-chain fatty acids	74-96	insulin	Homo sapiens	151-158
35516426-7	2022	The content of eight long-chain fatty acids (LCFAs) was significantly increased in mice with Rb1, which was positively correlated with the increase of Akkermansia and Parasuttereller, and negatively correlated with the decrease of Oscillibacter and Intestinimonas.	long-chain fatty acids	21-43	RB transcriptional corepressor 1	Mus musculus	93-96
35379526-3	2022	ELOVL1 catalyzes fatty acid elongation to produce very long-chain fatty acids (VLCFAs; >=C21), most of which are components of sphingolipids such as ceramides and sphingomyelins.	long-chain fatty acids	55-77	ELOVL fatty acid elongase 1	Homo sapiens	0-6
35416753-1	2022	Fatty acid binding protein 3 (FABP3) is involved in signal transduction pathways, and in the uptake and utilization of long-chain fatty acids.	long-chain fatty acids	119-141	fatty acid-binding protein, heart	Capra hircus	0-28
35416753-1	2022	Fatty acid binding protein 3 (FABP3) is involved in signal transduction pathways, and in the uptake and utilization of long-chain fatty acids.	long-chain fatty acids	119-141	fatty acid-binding protein, heart	Capra hircus	30-35
35119129-1	2022	Our objective was to determine the effects of chemical structure, amount, and site of infusion of long-chain fatty acids (LCFA) in lactating dairy cows.	long-chain fatty acids	98-120	LCFA	Bos taurus	122-126
35479665-2	2022	The dysfunction of ALD protein, a peroxisomal ATP-binding cassette transporter, results in the excessive saturated very long-chain fatty acids (VLCFAs) accumulation in organs including the brain, spine, and adrenal cortex.	long-chain fatty acids	120-142	ATP binding cassette subfamily D member 1	Homo sapiens	19-22
35479665-2	2022	The dysfunction of ALD protein, a peroxisomal ATP-binding cassette transporter, results in the excessive saturated very long-chain fatty acids (VLCFAs) accumulation in organs including the brain, spine, and adrenal cortex.	long-chain fatty acids	120-142	ATP binding cassette subfamily A member 4	Homo sapiens	46-78
2671390-2	1989	Rat intestinal fatty-acid-binding protein (I-FABP) is a small (15,124 Mr) cytoplasmic polypeptide that binds long-chain fatty acids in a non-covalent fashion.	long-chain fatty acids	109-131	fatty acid binding protein 2	Rattus norvegicus	4-41
2671390-2	1989	Rat intestinal fatty-acid-binding protein (I-FABP) is a small (15,124 Mr) cytoplasmic polypeptide that binds long-chain fatty acids in a non-covalent fashion.	long-chain fatty acids	109-131	fatty acid binding protein 2	Rattus norvegicus	43-49
2917153-8	1989	We conclude that a limited gastric lipolysis of human milk triacylglycerol, resulting in a release of a low concentration of long-chain fatty acids, is of major importance for the subsequent hydrolysis by colipase-dependent lipase in the duodenum.	long-chain fatty acids	125-147	colipase	Homo sapiens	205-213
2564395-5	1989	VIP appeared to specifically enhance the oxidation of long-chain fatty acids since its effects were counteracted by 5.10(-5) M sodium 2-[6-(chlorophenoxy)hexyl]oxirane-2-carboxylate, a potent inhibitor of carnitine palmitoyltransferase 1, and since VIP did not affect cell respiration in the presence of octanoate.	long-chain fatty acids	54-76	vasoactive intestinal peptide	Rattus norvegicus	0-3
2564395-5	1989	VIP appeared to specifically enhance the oxidation of long-chain fatty acids since its effects were counteracted by 5.10(-5) M sodium 2-[6-(chlorophenoxy)hexyl]oxirane-2-carboxylate, a potent inhibitor of carnitine palmitoyltransferase 1, and since VIP did not affect cell respiration in the presence of octanoate.	long-chain fatty acids	54-76	vasoactive intestinal peptide	Rattus norvegicus	249-252
3525233-1	1986	The activity of hepatic fatty acid synthase (EC 2.3.1.85) correlates positively with the rate of synthesis of long-chain fatty acids.	long-chain fatty acids	110-132	fatty acid synthase	Gallus gallus	24-43
2640356-0	1989	[The effect of a diet containing long-chain fatty acids on the formation of insoluble elastin in the rat aorta].	long-chain fatty acids	33-55	elastin	Rattus norvegicus	86-93
2640356-1	1989	The paper deals with the influence of long-chain fatty acids on the formation of insoluble elastin in vivo.	long-chain fatty acids	38-60	elastin	Rattus norvegicus	91-98
3230185-8	1988	The soybean oil diet reduced short-chain fatty acids and increased long-chain fatty acids in milk.	long-chain fatty acids	67-89	Weaning weight-maternal milk	Bos taurus	93-97
3297651-2	1987	Insulin action (measured as the effect on incorporation of acetate-carbon into long-chain fatty acids) was unaffected by bGH in short term incubations regardless of whether hydrocortisone (HC) was present.	long-chain fatty acids	79-101	insulin	Bos taurus	0-7
2882519-5	1987	We conclude that the deficiency of peroxisomal 3-oxoacyl-CoA thiolase is responsible for the very low peroxisomal beta-oxidation activity and for the accumulation of very-long-chain fatty acids and intermediates in the biosynthesis of bile acids.	long-chain fatty acids	171-193	acetyl-CoA acyltransferase 1	Homo sapiens	35-69
6241020-2	1984	The results emphasize a decrease of long-chain fatty acids (greater than C18) in the hyperkeratotic tissues.	long-chain fatty acids	36-58	Bardet-Biedl syndrome 9	Homo sapiens	73-76
2869786-0	1986	Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin.	long-chain fatty acids	10-32	serpin family A member 7	Homo sapiens	91-117
6426504-1	1984	The activity of an NAD:arginine ADP-ribosyltransferase was stimulated 4-6-fold by lysolecithin; lysolecithins containing long-chain fatty acids such as stearoyl (C18) and palmitoyl (C16) were more effective than those with shorter chains: C14 greater than C12 greater than C10 congruent to C8.	long-chain fatty acids	121-143	Bardet-Biedl syndrome 9	Homo sapiens	162-165
6426504-1	1984	The activity of an NAD:arginine ADP-ribosyltransferase was stimulated 4-6-fold by lysolecithin; lysolecithins containing long-chain fatty acids such as stearoyl (C18) and palmitoyl (C16) were more effective than those with shorter chains: C14 greater than C12 greater than C10 congruent to C8.	long-chain fatty acids	121-143	chromosome 12 open reading frame 57	Homo sapiens	273-276
6367855-1	1983	Stimulation of lipid synthesis by insulin in MCF-7 human breast cancer cells is characterized by an increase in acetate incorporation into long-chain fatty acids.	long-chain fatty acids	139-161	insulin	Homo sapiens	34-41
6185269-0	1982	Long-chain fatty acids bound to alpha-fetoprotein and to serum albumin from fetal and adult pig.	long-chain fatty acids	0-22	alpha fetoprotein	Sus scrofa	32-49
720331-1	1978	Imidazolide derivatives of long-chain fatty acids are shown to be potent irreversible activators of bee venom phospholipase A2.	long-chain fatty acids	27-49	phospholipase A2 group IB	Homo sapiens	110-126
381617-3	1979	Fat balance studies during the ingestion of a formula containing long-chain fatty acids demonstrated significant degrees of steatorrhea in patients (mean CFA 70.6 +/- 10.7 compared to 90.3 +/- 2.4 in control subjects).	long-chain fatty acids	65-87	FAT atypical cadherin 1	Homo sapiens	0-3
638175-9	1978	These results confirm and extend our previous findings of inhibition of progesterone binding to human albumin by long-chain fatty acids.	long-chain fatty acids	113-135	albumin	Homo sapiens	102-109
34020866-1	2021	Carnitine palmitoyl transferase II (CPT II) catalyzes the release of activated long-chain fatty acids from acylcarnitines into mitochondria for subsequent fatty acid oxidation.	long-chain fatty acids	79-101	carnitine palmitoyltransferase 2	Homo sapiens	0-34
4655826-11	1972	When mammary explants from rabbits pregnant for 23 days were cultured for 2 days with insulin, corticosterone and prolactin, the rate of fatty acid synthesis increased fivefold, but there was a preferential synthesis of long-chain fatty acids.	long-chain fatty acids	220-242	insulin	Oryctolagus cuniculus	86-93
5167104-0	1971	The action of pure pig pancreatic lipase upon esters of long-chain fatty acids and short-chain primary alcohols.	long-chain fatty acids	56-78	pancreatic lipase	Sus scrofa	23-40
33900381-1	2021	Fatty acid transport protein 4 (FATP4) belongs to a family of acyl-CoA synthetases which activate long-chain fatty acids into acyl-CoAs subsequently used in specific metabolic pathways.	long-chain fatty acids	98-120	solute carrier family 27 member 4	Homo sapiens	0-30
33900381-1	2021	Fatty acid transport protein 4 (FATP4) belongs to a family of acyl-CoA synthetases which activate long-chain fatty acids into acyl-CoAs subsequently used in specific metabolic pathways.	long-chain fatty acids	98-120	solute carrier family 27 member 4	Homo sapiens	32-37
34010726-1	2021	Spexin is a newly described peptide and is known to reduce the uptake of long-chain fatty acids into adipocytes.	long-chain fatty acids	73-95	spexin hormone	Homo sapiens	0-6
20301763-0	1993	Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency CLINICAL CHARACTERISTICS: Deficiency of very long-chain acyl-CoA dehydrogenase (VLCAD), which catalyzes the initial step of mitochondrial beta-oxidation of long-chain fatty acids with a chain length of 14 to 20 carbons, is associated with three phenotypes.	long-chain fatty acids	213-235	acyl-CoA dehydrogenase very long chain	Homo sapiens	137-142
33373044-2	2021	The disease is caused by mutations in the ABCD1 gene resulting in a defect in peroxisomal degradation of very long-chain fatty acids (VLCFA) and their accumulation in plasma and tissues.	long-chain fatty acids	110-132	ATP binding cassette subfamily D member 1	Homo sapiens	42-47
1155596-0	1975	Z protein in hepatic uptake and esterification of long-chain fatty acids.	long-chain fatty acids	50-72	fatty acid binding protein 1	Rattus norvegicus	0-9
1155596-5	1975	These results suggest that the binding of long-chain fatty acids to Z protein is not an obligatory step in their uptakeby the liver and that Z protein may be involved in fatty acid esterification.	long-chain fatty acids	42-64	fatty acid binding protein 1	Rattus norvegicus	68-77
5773785-0	1969	Binding of long-chain fatty acids to bovine serum albumin.	long-chain fatty acids	11-33	albumin	Homo sapiens	44-57
14021680-0	1962	[Effect of human pancreatic lipase on mixed, symmetrical, synthetic triglycerides made up of long-chain fatty acids and of butyric acid].	long-chain fatty acids	93-115	pancreatic lipase	Homo sapiens	17-34
13489882-0	1957	The binding of various long-chain fatty acids by serum albumin.	long-chain fatty acids	23-45	albumin	Homo sapiens	49-62
34020866-1	2021	Carnitine palmitoyl transferase II (CPT II) catalyzes the release of activated long-chain fatty acids from acylcarnitines into mitochondria for subsequent fatty acid oxidation.	long-chain fatty acids	79-101	carnitine palmitoyltransferase 2	Homo sapiens	36-42
33900028-7	2021	Moreover, targeted fatty acid analysis by GC-MS showed a significant decrease in the hepatic concentration of certain very long-chain fatty acids (VLCFA) in CR offspring, partially or totally reverted by leptin supplementation.	long-chain fatty acids	123-145	leptin	Rattus norvegicus	204-210
33724708-4	2021	We demonstrate that premature death of hlh-30 animals under starvation can be prevented by supplementation of exogenous fatty acids, and that HLH-30 is required for complete oxidation of long-chain fatty acids.	long-chain fatty acids	187-209	Helix-loop-helix protein 30	Caenorhabditis elegans	142-148
33210212-1	2021	Peroxisome proliferator-activated receptor (PPAR) beta/delta belongs to the family of hormone and lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids, cholesterol, and sphingolipids.	long-chain fatty acids	169-191	peroxisome proliferator activated receptor delta	Homo sapiens	0-60
33742447-11	2022	The results here suggest that the ELOVL6 can catalyse the synthesis of long-chain fatty acids in the BuMECs, and it can indirectly affect the expression of genes related to milk fat synthesis through its catalytic products to promote the lipid biosynthesis of BuMECs.	long-chain fatty acids	71-93	ELOVL fatty acid elongase 6	Homo sapiens	34-40
33533304-0	2021	Carbonic anhydrase 8 (Car8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids.	long-chain fatty acids	107-129	carbonic anhydrase 8	Mus musculus	0-20
33533304-0	2021	Carbonic anhydrase 8 (Car8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids.	long-chain fatty acids	107-129	carbonic anhydrase 8	Mus musculus	22-26
33533304-0	2021	Carbonic anhydrase 8 (Car8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids.	long-chain fatty acids	107-129	glucagon	Mus musculus	49-54
33343508-4	2020	ChREBP regulates fatty acid synthesis, elongation, and desaturation by inducing Acc1 and Fasn, elongation of long-chain fatty acids family member 6 (encoded by Elovl6), and Scd1 expression, respectively.	long-chain fatty acids	109-131	MLX interacting protein like	Homo sapiens	0-6
33861460-1	2021	Fatty Acid Binding-Protein 5 (FABP5) is a cytoplasmic protein, which binds long-chain fatty acids and other hydrophobic ligands.	long-chain fatty acids	75-97	fatty acid binding protein 5	Homo sapiens	0-28
33861460-1	2021	Fatty Acid Binding-Protein 5 (FABP5) is a cytoplasmic protein, which binds long-chain fatty acids and other hydrophobic ligands.	long-chain fatty acids	75-97	fatty acid binding protein 5	Homo sapiens	30-35
33343508-4	2020	ChREBP regulates fatty acid synthesis, elongation, and desaturation by inducing Acc1 and Fasn, elongation of long-chain fatty acids family member 6 (encoded by Elovl6), and Scd1 expression, respectively.	long-chain fatty acids	109-131	ELOVL fatty acid elongase 6	Homo sapiens	160-166
33247737-3	2021	A critical role for ACC in de novo synthesis of long-chain fatty acids during fetal development has been demonstrated in studies in mice lacking Acc1, where the absence of Acc1 results in early embryonic lethality.	long-chain fatty acids	48-70	acetyl-Coenzyme A carboxylase alpha	Mus musculus	145-149
33247737-3	2021	A critical role for ACC in de novo synthesis of long-chain fatty acids during fetal development has been demonstrated in studies in mice lacking Acc1, where the absence of Acc1 results in early embryonic lethality.	long-chain fatty acids	48-70	acetyl-Coenzyme A carboxylase alpha	Mus musculus	172-176
32868338-0	2020	The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4.	long-chain fatty acids	48-70	TBC1 domain family, member 1	Mus musculus	12-18
33207796-8	2020	ACSL4 catalyzes the activation of long-chain fatty acids for cellular lipid synthesis.	long-chain fatty acids	34-56	acyl-CoA synthetase long chain family member 4	Bos taurus	0-5
32868338-0	2020	The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4.	long-chain fatty acids	48-70	TBC1 domain family, member 4	Mus musculus	23-29
32868338-0	2020	The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4.	long-chain fatty acids	48-70	solute carrier family 27 (fatty acid transporter), member 4	Mus musculus	119-126
32868338-0	2020	The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4.	long-chain fatty acids	48-70	solute carrier family 27 (fatty acid transporter), member 4	Mus musculus	127-132
32968186-6	2020	The proteins related to the biosynthesis of lignin, flavonoids and long-chain fatty acids, including phenylalanine ammonia lyase, cinnamoyl-CoA reductase, peroxidase, chalcone synthase, flavanone 3-hydroxylase, flavonol synthase, acetyl-CoA carboxylase 1,3-ketoacyl-CoA synthase 6 and 3-ketoacyl-CoA reductase 1, were downregulated.	long-chain fatty acids	67-89	acetyl-CoA carboxylase alpha	Homo sapiens	230-254
33195520-2	2020	Major long-chain fatty acids (LCFA) in NEFA are palmitic (PA), palmitoleic (POA), stearic (SA), oleic (OA), and linoleic (LA) acid.	long-chain fatty acids	6-28	LCFA	Bos taurus	30-34
32799609-1	2020	INTRODUCTION: G protein-coupled receptor 120 (GPR120) is a Galphaq coupled GPCR specifically activated by long-chain fatty acids (LCFAs).	long-chain fatty acids	106-128	free fatty acid receptor 4	Homo sapiens	14-44
32799609-1	2020	INTRODUCTION: G protein-coupled receptor 120 (GPR120) is a Galphaq coupled GPCR specifically activated by long-chain fatty acids (LCFAs).	long-chain fatty acids	106-128	free fatty acid receptor 4	Homo sapiens	46-52
32799609-1	2020	INTRODUCTION: G protein-coupled receptor 120 (GPR120) is a Galphaq coupled GPCR specifically activated by long-chain fatty acids (LCFAs).	long-chain fatty acids	106-128	G protein subunit alpha q	Homo sapiens	59-66
33027714-3	2020	Two main functions of FATP2 are to activate long-chain fatty acids (LCFAs) as a very long-chain acyl-coenzyme A (CoA) synthetase (ACSVL) and to transport LCFAs as a fatty acid transporter.	long-chain fatty acids	44-66	solute carrier family 27 member 2	Homo sapiens	22-27
32582686-4	2020	Liquid chromatography coupled with mass spectrometry (LC-MS) based detection of differential proteomics revealed that TUDCA reduces the mitochondrial levels of the long-chain acyl-CoA dehydrogenase (LCAD), an enzyme crucial for beta-oxidation of long-chain fatty acids (FA).	long-chain fatty acids	246-268	acyl-CoA dehydrogenase, long chain	Rattus norvegicus	164-197
32820071-5	2020	By complementary biophysical approaches, we show that the START domain binds to long-chain fatty acids, products of Them1"s enzymatic reaction, as well as lysophosphatidylcholine (LPC), lipids shown to activate thermogenesis in brown adipocytes.	long-chain fatty acids	80-102	acyl-CoA thioesterase 11	Homo sapiens	116-121
32314517-5	2020	Besides, derivatization with long-chain fatty acids yielded potent sirtuin 2 inhibitors, featuring another intriguing aspect of azo-based photoswitches.	long-chain fatty acids	29-51	sirtuin 2	Homo sapiens	67-76
32756427-6	2020	Moreover, considering the ability of the long-chain fatty acids (LCFAs) to displace ATRA from FABP5, the actions of the saturated palmitic acid (PA), unsaturated omega-6 linoleic acid (LA) and omega-3 docosahexaenoic acid (DHA) were evaluated to counteract ATRA-related proliferation.	long-chain fatty acids	41-63	fatty acid binding protein 5	Homo sapiens	94-99
32875445-4	2020	Cytochrome P450 metabolism of specifically long-chain fatty acids forms epoxide metabolites, the epoxy-fatty acids (EpFA).	long-chain fatty acids	43-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
32491160-0	2020	Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells.	long-chain fatty acids	16-38	CD8a molecule	Homo sapiens	107-110
32491160-5	2020	Here, we found that intrapancreatic CD8+ T cells progressively accumulate specific long-chain fatty acids (LCFAs), which, rather than provide a fuel source, impair their mitochondrial function and trigger major transcriptional reprogramming of pathways involved in lipid metabolism, with the subsequent reduction of fatty acid catabolism.	long-chain fatty acids	83-105	CD8a molecule	Homo sapiens	36-39
32694731-3	2020	Here, we use pooled genome-wide CRISPR screens to systematically map genetic interactions (GIs) in human HAP1 cells carrying a loss-of-function mutation in fatty acid synthase (FASN), whose product catalyses the formation of long-chain fatty acids.	long-chain fatty acids	225-247	fatty acid synthase	Homo sapiens	156-175
32694731-3	2020	Here, we use pooled genome-wide CRISPR screens to systematically map genetic interactions (GIs) in human HAP1 cells carrying a loss-of-function mutation in fatty acid synthase (FASN), whose product catalyses the formation of long-chain fatty acids.	long-chain fatty acids	225-247	fatty acid synthase	Homo sapiens	177-181
32582686-4	2020	Liquid chromatography coupled with mass spectrometry (LC-MS) based detection of differential proteomics revealed that TUDCA reduces the mitochondrial levels of the long-chain acyl-CoA dehydrogenase (LCAD), an enzyme crucial for beta-oxidation of long-chain fatty acids (FA).	long-chain fatty acids	246-268	acyl-CoA dehydrogenase, long chain	Rattus norvegicus	199-203
31173805-1	2019	Heart fatty acid-binding protein (H-FABP) belongs to a family of intracellular fatty acid-binding proteins that are involved in the transport of long-chain fatty acids.	long-chain fatty acids	145-167	fatty acid-binding protein, heart	Sus scrofa	0-32
32188695-1	2020	Fatty acid transport protein 2 (FATP2) is highly expressed in the liver, small intestine, and kidney, where it functions in both the transport of exogenous long-chain fatty acids and the activation of very-long-chain fatty acids.	long-chain fatty acids	156-178	solute carrier family 27 (fatty acid transporter), member 2	Mus musculus	32-37
32243843-6	2020	MTLN directly interacts with the beta subunit of the mitochondrial trifunctional protein, an enzyme critical in the beta-oxidation of long-chain fatty acids.	long-chain fatty acids	134-156	mitoregulin	Homo sapiens	0-4
32120190-5	2020	Long-chain fatty acids stimulate angiogenesis in these cells via vascular endothelium growth factor (VEGF), angiopoietin-like protein 4 (ANGPTL4), fatty acid-binding proteins (FABPs), or eicosanoids.	long-chain fatty acids	0-22	vascular endothelial growth factor A	Homo sapiens	65-99
32120190-5	2020	Long-chain fatty acids stimulate angiogenesis in these cells via vascular endothelium growth factor (VEGF), angiopoietin-like protein 4 (ANGPTL4), fatty acid-binding proteins (FABPs), or eicosanoids.	long-chain fatty acids	0-22	vascular endothelial growth factor A	Homo sapiens	101-105
32120190-5	2020	Long-chain fatty acids stimulate angiogenesis in these cells via vascular endothelium growth factor (VEGF), angiopoietin-like protein 4 (ANGPTL4), fatty acid-binding proteins (FABPs), or eicosanoids.	long-chain fatty acids	0-22	angiopoietin like 4	Homo sapiens	108-135
32120190-5	2020	Long-chain fatty acids stimulate angiogenesis in these cells via vascular endothelium growth factor (VEGF), angiopoietin-like protein 4 (ANGPTL4), fatty acid-binding proteins (FABPs), or eicosanoids.	long-chain fatty acids	0-22	angiopoietin like 4	Homo sapiens	137-144
31350932-0	2020	AKR2A participates in the regulation of cotton fibre development by modulating biosynthesis of very-long-chain fatty acids.	long-chain fatty acids	100-122	ankyrin repeat-containing protein 2	Arabidopsis thaliana	0-5
32010688-1	2019	Very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) is a coenzyme encoded by ACADVL that converts very-long-chain fatty acids into energy.	long-chain fatty acids	105-127	acyl-CoA dehydrogenase very long chain	Homo sapiens	0-45
32010688-1	2019	Very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) is a coenzyme encoded by ACADVL that converts very-long-chain fatty acids into energy.	long-chain fatty acids	105-127	acyl-CoA dehydrogenase very long chain	Homo sapiens	47-52
32010688-1	2019	Very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) is a coenzyme encoded by ACADVL that converts very-long-chain fatty acids into energy.	long-chain fatty acids	105-127	acyl-CoA dehydrogenase very long chain	Homo sapiens	79-85
31777199-1	2020	BACKGROUND: X-linked adrenoleukodystrophy (ALD) is one of the most common peroxisomal disorders characterized by abnormal accumulation of very long-chain fatty acids (VLCFA) in plasma and tissues and caused by mutations within ABCD1.	long-chain fatty acids	143-165	ATP binding cassette subfamily D member 1	Homo sapiens	227-232
31326818-1	2019	Facilitating anaerobic degradation of long-chain fatty acids (LCFA) is key for tapping the high methane production potential of the fats, oil and grease (FOG) content of dairy wastewaters.	long-chain fatty acids	38-60	chromosome 10 open reading frame 90	Homo sapiens	132-152
31504388-1	2019	ACSL4 is a member of the ACSL family that catalyzes the conversion of long-chain fatty acids to acyl-coenzyme As, which are essential for fatty-acid incorporation and utilization in diverse metabolic pathways, including cholesteryl ester synthesis.	long-chain fatty acids	70-92	acyl-CoA synthetase long-chain family member 4	Mus musculus	0-5
31451493-1	2019	Liver fatty acid-binding protein (LFABP) binds long-chain fatty acids with high affinity and is abundantly expressed in the liver and small intestine.	long-chain fatty acids	47-69	fatty acid binding protein 1, liver	Mus musculus	0-32
31451493-1	2019	Liver fatty acid-binding protein (LFABP) binds long-chain fatty acids with high affinity and is abundantly expressed in the liver and small intestine.	long-chain fatty acids	47-69	fatty acid binding protein 1, liver	Mus musculus	34-39
31059784-6	2019	Also, groups fed diet VCO and CO expressed highly in LPL, whereas, elongase of very long-chain fatty acids (ELOVL-5) was not influenced by the lipid sources.	long-chain fatty acids	84-106	elongation of very long chain fatty acids protein 5	Oreochromis niloticus	108-115
31073775-8	2019	Consistently upregulated genes on the 15th and 30th days of early postpartum indicated the promotion of immune tolerance (e.g., IFITM3), medium and long-chain fatty acids" oxidation (e.g., ACSM3), and lipid accumulation (e.g., INSIG1).	long-chain fatty acids	148-170	interferon induced transmembrane protein 3	Homo sapiens	128-134
31073775-8	2019	Consistently upregulated genes on the 15th and 30th days of early postpartum indicated the promotion of immune tolerance (e.g., IFITM3), medium and long-chain fatty acids" oxidation (e.g., ACSM3), and lipid accumulation (e.g., INSIG1).	long-chain fatty acids	148-170	insulin induced gene 1	Homo sapiens	227-233
32434239-4	2021	Moreover, we studied DNA methylation of FASN (fatty acid synthase), that catalyses the synthesis of long-chain fatty acids, in VAT of the same subjects and whether it is associated with metabolic traits.	long-chain fatty acids	100-122	fatty acid synthase	Homo sapiens	40-44
32434239-4	2021	Moreover, we studied DNA methylation of FASN (fatty acid synthase), that catalyses the synthesis of long-chain fatty acids, in VAT of the same subjects and whether it is associated with metabolic traits.	long-chain fatty acids	100-122	fatty acid synthase	Homo sapiens	46-65
32202512-4	2020	Myelin lipids, especially the monounsaturated fatty acids and very-long-chain fatty acids, were dramatically reduced by Qki depletion, whereas the major myelin proteins remained intact, and the demyelinating phenotypes of Qki-depleted mice were alleviated by a high-fat diet.	long-chain fatty acids	67-89	quaking, KH domain containing RNA binding	Mus musculus	120-123
32146873-9	2020	Acyl-CoA synthetase-1 (ACSL1), known for activating long-chain fatty acids, was decreased in moderate and severe cachexia based on LC-MS/MS and immunoblotting.	long-chain fatty acids	52-74	acyl-CoA synthetase long-chain family member 1	Mus musculus	23-28
32188695-1	2020	Fatty acid transport protein 2 (FATP2) is highly expressed in the liver, small intestine, and kidney, where it functions in both the transport of exogenous long-chain fatty acids and the activation of very-long-chain fatty acids.	long-chain fatty acids	156-178	solute carrier family 27 (fatty acid transporter), member 2	Mus musculus	0-30
32546357-5	2020	One such regulator is carnitine palmitoyltransferase 1A (CPT1A), which is involved in transportation of long-chain fatty acids into the mitochondrial matrix for beta-oxidation, thereby providing an alternative pathway for the generation of energy for tumour growth and development.	long-chain fatty acids	104-126	carnitine palmitoyltransferase 1A	Canis lupus familiaris	22-55
32546357-5	2020	One such regulator is carnitine palmitoyltransferase 1A (CPT1A), which is involved in transportation of long-chain fatty acids into the mitochondrial matrix for beta-oxidation, thereby providing an alternative pathway for the generation of energy for tumour growth and development.	long-chain fatty acids	104-126	carnitine palmitoyltransferase 1A	Canis lupus familiaris	57-62
31173805-1	2019	Heart fatty acid-binding protein (H-FABP) belongs to a family of intracellular fatty acid-binding proteins that are involved in the transport of long-chain fatty acids.	long-chain fatty acids	145-167	fatty acid-binding protein, heart	Sus scrofa	34-40
31078517-1	2019	FFA4 (Free Fatty Acid receptor 4, previously known as GPR120) is a G protein-coupled receptor that acts as a sensor of long-chain fatty acids, modulates metabolism, and whose dysfunction participates in endocrine disturbances.	long-chain fatty acids	119-141	free fatty acid receptor 4	Homo sapiens	0-4
31388073-5	2019	Quantitative analysis of extracellular long-chain fatty acids and aliphatic alcohols in the atabcg1 mutants demonstrated altered root suberin composition, specifically a reduction in longer chain dicarboxylic acids, fatty alcohols and acids.	long-chain fatty acids	39-61	ABC-2 type transporter family protein	Arabidopsis thaliana	92-99
31427678-7	2019	We hypothesize that the failure in turning on BAT thermogenesis occurs due to accumulation of unsaturated long-chain fatty acids or their metabolites in Decr-/- mice BAT suppressing down-stream propagation of NE-signaling.	long-chain fatty acids	106-128	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	153-157
31078517-1	2019	FFA4 (Free Fatty Acid receptor 4, previously known as GPR120) is a G protein-coupled receptor that acts as a sensor of long-chain fatty acids, modulates metabolism, and whose dysfunction participates in endocrine disturbances.	long-chain fatty acids	119-141	free fatty acid receptor 4	Homo sapiens	6-32
31078517-1	2019	FFA4 (Free Fatty Acid receptor 4, previously known as GPR120) is a G protein-coupled receptor that acts as a sensor of long-chain fatty acids, modulates metabolism, and whose dysfunction participates in endocrine disturbances.	long-chain fatty acids	119-141	free fatty acid receptor 4	Homo sapiens	54-60
30857422-5	2019	Compared with EtOH feeding, CB feeding resulted in higher concentrations of functional saturated long-chain fatty acids and short-chain fatty acids.	long-chain fatty acids	97-119	cathepsin B	Mus musculus	28-30
31242216-12	2019	In blood serum, C18:1trans11 limited the synthesis of long-chain fatty acids.	long-chain fatty acids	54-76	Bardet-Biedl syndrome 9	Homo sapiens	16-19
30831087-2	2019	In fact, we previously reported that stress-induced pain prolongation might be mediated through the suppression of the G-protein coupled-receptor 40/free fatty acid receptor 1 (GPR40/FFAR1), which is activated by DHA and long-chain fatty acids.	long-chain fatty acids	221-243	free fatty acid receptor 1	Mus musculus	177-182
30831087-2	2019	In fact, we previously reported that stress-induced pain prolongation might be mediated through the suppression of the G-protein coupled-receptor 40/free fatty acid receptor 1 (GPR40/FFAR1), which is activated by DHA and long-chain fatty acids.	long-chain fatty acids	221-243	free fatty acid receptor 1	Mus musculus	183-188
31214048-1	2019	Long-chain fatty acids activate the free fatty acid receptor 1 (FFA1) and FFA4.	long-chain fatty acids	0-22	free fatty acid receptor 1	Homo sapiens	36-62
31214048-1	2019	Long-chain fatty acids activate the free fatty acid receptor 1 (FFA1) and FFA4.	long-chain fatty acids	0-22	free fatty acid receptor 1	Homo sapiens	64-68
30560457-2	2019	Recent studies have indicated that these cells express GPR120 (also known as FFAR4), the G protein-coupled receptor for long-chain fatty acids (LCFAs).	long-chain fatty acids	120-142	free fatty acid receptor 4	Mus musculus	55-61
30358470-1	2019	Mutations in the gene encoding the peroxisomal ATP-binding cassette transporter (ABCD1) cause elevations in very long-chain fatty acids (VLCFAs) and the neurodegenerative disease adrenoleukodystrophy (ALD).	long-chain fatty acids	113-135	ATP-binding cassette, sub-family A (ABC1), member 13	Mus musculus	47-79
30358470-1	2019	Mutations in the gene encoding the peroxisomal ATP-binding cassette transporter (ABCD1) cause elevations in very long-chain fatty acids (VLCFAs) and the neurodegenerative disease adrenoleukodystrophy (ALD).	long-chain fatty acids	113-135	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	81-86
30769094-1	2019	X-linked adrenoleukodystrophy (X-ALD), the most frequent peroxisomal disorder, is associated with mutation in the ABCD1 gene which encodes a peroxisomal ATP-binding cassette transporter for very long-chain fatty acids (VLCFA).	long-chain fatty acids	195-217	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	114-119
30560457-2	2019	Recent studies have indicated that these cells express GPR120 (also known as FFAR4), the G protein-coupled receptor for long-chain fatty acids (LCFAs).	long-chain fatty acids	120-142	free fatty acid receptor 4	Mus musculus	77-82
30333365-1	2019	It is known that long-chain fatty acids bind to free fatty acid receptor 1 (Ffar1), also known as G protein-coupled receptor 40 (GPR40), and amplify glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells and that Ffar1 agonists facilitates insulin secretion and ameliorates glycemic control.	long-chain fatty acids	17-39	free fatty acid receptor 1	Mus musculus	48-74
30540494-0	2019	Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4.	long-chain fatty acids	36-58	ATP binding cassette subfamily D member 3	Homo sapiens	87-92
30540494-0	2019	Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4.	long-chain fatty acids	36-58	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	97-104
30982505-0	2019	ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function.	long-chain fatty acids	13-35	ELOVL fatty acid elongase 4	Homo sapiens	0-6
30738829-5	2019	FINDINGS: We identified that GPR120, a receptor for long-chain fatty acids, was important for the acquisition of chemoresistance in breast cancer cells.	long-chain fatty acids	52-74	free fatty acid receptor 4	Homo sapiens	29-35
30764601-6	2019	We also found that G-protein-coupled receptor 120 (GPR120), a receptor of long-chain fatty acids, is expressed in SNU-601/cis2 cells, and the knockdown of GPR120 using specific shRNAs alleviated DHA-mediated ROS production and apoptosis.	long-chain fatty acids	74-96	free fatty acid receptor 4	Homo sapiens	19-49
30764601-6	2019	We also found that G-protein-coupled receptor 120 (GPR120), a receptor of long-chain fatty acids, is expressed in SNU-601/cis2 cells, and the knockdown of GPR120 using specific shRNAs alleviated DHA-mediated ROS production and apoptosis.	long-chain fatty acids	74-96	free fatty acid receptor 4	Homo sapiens	51-57
30764601-6	2019	We also found that G-protein-coupled receptor 120 (GPR120), a receptor of long-chain fatty acids, is expressed in SNU-601/cis2 cells, and the knockdown of GPR120 using specific shRNAs alleviated DHA-mediated ROS production and apoptosis.	long-chain fatty acids	74-96	free fatty acid receptor 4	Homo sapiens	155-161
30333365-1	2019	It is known that long-chain fatty acids bind to free fatty acid receptor 1 (Ffar1), also known as G protein-coupled receptor 40 (GPR40), and amplify glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells and that Ffar1 agonists facilitates insulin secretion and ameliorates glycemic control.	long-chain fatty acids	17-39	free fatty acid receptor 1	Mus musculus	76-81
30333365-1	2019	It is known that long-chain fatty acids bind to free fatty acid receptor 1 (Ffar1), also known as G protein-coupled receptor 40 (GPR40), and amplify glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells and that Ffar1 agonists facilitates insulin secretion and ameliorates glycemic control.	long-chain fatty acids	17-39	free fatty acid receptor 1	Mus musculus	98-127
30333365-1	2019	It is known that long-chain fatty acids bind to free fatty acid receptor 1 (Ffar1), also known as G protein-coupled receptor 40 (GPR40), and amplify glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells and that Ffar1 agonists facilitates insulin secretion and ameliorates glycemic control.	long-chain fatty acids	17-39	free fatty acid receptor 1	Mus musculus	129-134
30333365-1	2019	It is known that long-chain fatty acids bind to free fatty acid receptor 1 (Ffar1), also known as G protein-coupled receptor 40 (GPR40), and amplify glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells and that Ffar1 agonists facilitates insulin secretion and ameliorates glycemic control.	long-chain fatty acids	17-39	free fatty acid receptor 1	Mus musculus	229-234
30604175-4	2019	ELO2 and ELO3 are condensing enzymes that synthesize very-long-chain fatty acids (VLCFAs), major fatty acids in plant sphingolipids.	long-chain fatty acids	58-80	IKI3 family protein	Arabidopsis thaliana	0-4
29797089-3	2019	As an uncoupling protein, UCP1 transports H+ across the IMM in presence of long-chain fatty acids (FA), which makes brown fat mitochondria produce heat at the expense of ATP.	long-chain fatty acids	75-97	uncoupling protein 1	Homo sapiens	26-30
30604175-4	2019	ELO2 and ELO3 are condensing enzymes that synthesize very-long-chain fatty acids (VLCFAs), major fatty acids in plant sphingolipids.	long-chain fatty acids	58-80	radical SAM domain-containing protein / GCN5-related N-acetyltransferase (GNAT) family protein	Arabidopsis thaliana	9-13
30546814-2	2019	It is caused by a mutation of the ABCD1 gene, resulting in the impaired degradation of very long-chain fatty acids and their subsequent accumulation in several organs and tissues.	long-chain fatty acids	92-114	ATP binding cassette subfamily D member 1	Homo sapiens	34-39
29787827-2	2018	Fatty acid elongase 6 (ELOVL6), which elongates saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs), plays a distinct role in the balance of long-chain fatty acids composition in animals.	long-chain fatty acids	158-180	ELOVL fatty acid elongase 6	Bos taurus	23-29
30651994-2	2019	Mitochondrial carnitine palmitoyltransferase II (CPT II) plays an important role in adenosine triphosphate (ATP) generation from long-chain fatty acids, and its thermolabile phenotype of CPT2 polymorphisms leads to ATP production loss under high fever.	long-chain fatty acids	129-151	carnitine palmitoyltransferase 2	Homo sapiens	49-55
30199530-5	2018	Activated SSAO oppositely regulates uptake of glucose and long-chain fatty acids and remodels the cellular proteome to coordinate changes in fuel availability and related downstream processes, such as glycolysis, de novo lipogenesis, and sphingomyelin/ceramide synthesis.	long-chain fatty acids	58-80	amine oxidase copper containing 3	Homo sapiens	10-14
29787827-3	2018	ELOVL6 catalyzes the elongation of palmitic acids (C16:0) which is the most common saturated fatty acid found in animals and also an essential precursor to synthesize other long-chain fatty acids.	long-chain fatty acids	173-195	ELOVL fatty acid elongase 6	Bos taurus	0-6
29965978-1	2018	Stearoyl-CoA desaturase 1 (SCD1) catalyzes the rate limiting step in monounsaturated fatty acid synthesis by inserting a double bond at the delta-9 position of long-chain fatty acids.	long-chain fatty acids	160-182	stearoyl-Coenzyme A desaturase 1	Mus musculus	0-25
29733968-0	2018	Molecular characterization of elongase of very long-chain fatty acids 6 (elovl6) genes in Misgurnus anguillicaudatus and their potential roles in adaptation to cold temperature.	long-chain fatty acids	47-69	ELOVL fatty acid elongase 6	Homo sapiens	73-79
29733968-1	2018	Elongase of very long-chain fatty acids 6 (ELOVL6) is a rate-limiting enzyme catalyzing elongation of saturated and monounsaturated long-chain fatty acid.	long-chain fatty acids	17-39	ELOVL fatty acid elongase 6	Homo sapiens	43-49
29997171-3	2018	This rare neurometabolic disease is caused by the loss of function of the peroxisomal transporter ABCD1, leading to an accumulation of very long-chain fatty acids and the induction of reactive oxygen species of mitochondrial origin.	long-chain fatty acids	140-162	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	98-103
29965978-1	2018	Stearoyl-CoA desaturase 1 (SCD1) catalyzes the rate limiting step in monounsaturated fatty acid synthesis by inserting a double bond at the delta-9 position of long-chain fatty acids.	long-chain fatty acids	160-182	stearoyl-Coenzyme A desaturase 1	Mus musculus	27-31
29058795-1	2018	Fatty acid synthase (FAS) is an important enzyme involved in the de novo synthesis of long-chain fatty acids.	long-chain fatty acids	86-108	fatty acid synthase	Sus scrofa	0-19
29907775-6	2018	Our results suggest that the medium-chain fatty acid used for the acyl-modification of ghrelin is produced in ghrelin-producing cells themselves by beta-oxidation of long-chain fatty acids provided from the circulation.	long-chain fatty acids	166-188	ghrelin	Mus musculus	87-94
29907775-6	2018	Our results suggest that the medium-chain fatty acid used for the acyl-modification of ghrelin is produced in ghrelin-producing cells themselves by beta-oxidation of long-chain fatty acids provided from the circulation.	long-chain fatty acids	166-188	ghrelin	Mus musculus	110-117
29353241-12	2018	In endothelial-specific Rbp-jkappa-mutant mice, lipase activity and transendothelial transport of long-chain fatty acids to muscle cells were impaired.	long-chain fatty acids	98-120	recombination signal binding protein for immunoglobulin kappa J region	Mus musculus	24-34
29353241-14	2018	The attenuated supply of cardiomyocytes with long-chain fatty acids was accompanied by higher glucose uptake, increased concentration of glycolysis intermediates, and mTOR-S6K signaling.	long-chain fatty acids	45-67	mechanistic target of rapamycin kinase	Mus musculus	167-171
29115671-1	2018	Fatty Acid Elongase 7 (ELOVL7) is the newly discovered protein on human that catalyzes the rate-limiting step towards the synthesis of very long-chain fatty acids and exhibits the highest activity toward C18: 3 (n-3) acyl-CoAs, which is the precursor of eicosapentaenoic acid (EPA, 20: 5n-3).	long-chain fatty acids	140-162	ELOVL fatty acid elongase 7	Homo sapiens	23-29
29496980-4	2018	The functional effect of prioritised variant in ELOVL1 (very-long-chain fatty acids (VLCFAs) elongase) was analysed by VLCFA profiling by gas chromatography-mass spectrometry in stably transfected HEK2932 cells and in cultured patient"s fibroblasts.	long-chain fatty acids	61-83	ELOVL fatty acid elongase 1	Homo sapiens	48-54
29664569-4	2018	Moreover, it has been proposed that CD8+ Tmem cells have a specific requirement for the oxidation of long-chain fatty acids (LC-FAO), a process modulated in lymphocytes by the enzyme CPT1A.	long-chain fatty acids	101-123	CD8a molecule	Homo sapiens	36-39
29664569-4	2018	Moreover, it has been proposed that CD8+ Tmem cells have a specific requirement for the oxidation of long-chain fatty acids (LC-FAO), a process modulated in lymphocytes by the enzyme CPT1A.	long-chain fatty acids	101-123	carnitine palmitoyltransferase 1A	Homo sapiens	183-188
29581157-1	2018	Mitochondrial trifunctional protein (MTP) plays a critical role in the oxidation of long-chain fatty acids.	long-chain fatty acids	84-106	lysosomal-associated protein transmembrane 4A	Mus musculus	0-35
29581157-1	2018	Mitochondrial trifunctional protein (MTP) plays a critical role in the oxidation of long-chain fatty acids.	long-chain fatty acids	84-106	lysosomal-associated protein transmembrane 4A	Mus musculus	37-40
29805599-2	2018	The expression of G-protein coupled receptor 40 (GPR40), a membrane-bound receptor for long-chain fatty acids (LCFAs), was examined in 36 cases of subserosal-invading CRC and compared with clinicopathological parameters as well as triglyceride (TG) and low-density lipoprotein (LDL) levels in the blood.	long-chain fatty acids	87-109	free fatty acid receptor 1	Homo sapiens	18-47
29805599-2	2018	The expression of G-protein coupled receptor 40 (GPR40), a membrane-bound receptor for long-chain fatty acids (LCFAs), was examined in 36 cases of subserosal-invading CRC and compared with clinicopathological parameters as well as triglyceride (TG) and low-density lipoprotein (LDL) levels in the blood.	long-chain fatty acids	87-109	free fatty acid receptor 1	Homo sapiens	49-54
29277329-2	2018	Evidence indicates that this increased risk is linked to an altered cardiac substrate preference of the insulin resistant heart, which shifts from a balanced utilization of glucose and long-chain fatty acids (FAs) towards an almost complete reliance on FAs as main fuel source.	long-chain fatty acids	185-207	insulin	Homo sapiens	104-111
29058795-1	2018	Fatty acid synthase (FAS) is an important enzyme involved in the de novo synthesis of long-chain fatty acids.	long-chain fatty acids	86-108	fatty acid synthase	Sus scrofa	21-24
29700319-1	2018	The elongation of long-chain fatty acids family member 6 (Elovl6) is a key enzyme in lipogenesis that catalyzes the elongation of saturated and monounsaturated fatty acids.	long-chain fatty acids	18-40	ELOVL family member 6, elongation of long chain fatty acids (yeast)	Mus musculus	58-64
29362226-4	2018	VLC fatty acids that incorporate into VLC ceramides are produced by elongase elongation of very long-chain fatty acids protein 4 (ELOVL4).	long-chain fatty acids	96-118	ELOVL fatty acid elongase 4	Homo sapiens	130-136
29463677-2	2018	For instance, inhibition of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids, prevents the proinflammatory response in macrophages; however, the precise role of this enzyme in this response remains poorly defined.	long-chain fatty acids	89-111	fatty acid synthase	Homo sapiens	28-47
29463677-2	2018	For instance, inhibition of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids, prevents the proinflammatory response in macrophages; however, the precise role of this enzyme in this response remains poorly defined.	long-chain fatty acids	89-111	fatty acid synthase	Homo sapiens	49-53
28940384-7	2018	Impairment of peroxisomal beta-oxidation in Mfp2-/- BMDM did not cause lipid accumulation but rather an altered distribution of lipid species with very-long-chain fatty acids accumulating in the triglyceride and phospholipid fraction.	long-chain fatty acids	152-174	hydroxysteroid (17-beta) dehydrogenase 4	Mus musculus	44-48
29541228-1	2018	Fatty acid synthase (FASN) is the key enzyme required for the de novo synthesis of long-chain fatty acids.	long-chain fatty acids	83-105	fatty acid synthase	Homo sapiens	0-19
29541228-1	2018	Fatty acid synthase (FASN) is the key enzyme required for the de novo synthesis of long-chain fatty acids.	long-chain fatty acids	83-105	fatty acid synthase	Homo sapiens	21-25
29557549-3	2018	The loss of functioning of ABCD1 triggers ineffective beta oxidation of very long-chain fatty acids, which gives rise to an accumulation of these fatty acids.	long-chain fatty acids	77-99	ATP binding cassette subfamily D member 1	Homo sapiens	27-32
29596410-8	2018	Taken together, these results suggest that transport of at least some long-chain fatty acids into the mitochondria by CPT1 may be required for anabolic processes that support healthy mitochondrial function and cancer cell proliferation independent of FAO.	long-chain fatty acids	70-92	carnitine palmitoyltransferase 1A	Homo sapiens	118-122
29321392-1	2018	G-protein-coupled receptor 40 (GPR40)/free fatty acid receptor (FFAR) 1 is activated by long-chain fatty acids such as docosahexaenoic acid (DHA).	long-chain fatty acids	88-110	free fatty acid receptor 1	Homo sapiens	0-29
29467325-10	2018	Downregulation of ELOVL3/ELOVL6 expression in keratinocytes by siRNA decreased the proportion of long-chain fatty acids globally and in sphingolipids.	long-chain fatty acids	97-119	ELOVL fatty acid elongase 3	Homo sapiens	18-24
29467325-10	2018	Downregulation of ELOVL3/ELOVL6 expression in keratinocytes by siRNA decreased the proportion of long-chain fatty acids globally and in sphingolipids.	long-chain fatty acids	97-119	ELOVL fatty acid elongase 6	Homo sapiens	25-31
29293497-5	2018	While PC-3/M cells showed an enhanced entry of long-chain fatty acids into the mitochondria, PC-3/S cells used long-chain fatty acids as precursors of eicosanoid metabolism.	long-chain fatty acids	47-69	chromobox 8	Homo sapiens	6-10
29293497-5	2018	While PC-3/M cells showed an enhanced entry of long-chain fatty acids into the mitochondria, PC-3/S cells used long-chain fatty acids as precursors of eicosanoid metabolism.	long-chain fatty acids	111-133	chromobox 8	Homo sapiens	93-97
30016793-1	2018	BACKGROUND/AIMS: Carnitine palmitoyltransferase 1A (CPT1A) is a rate-limiting enzyme in the transport of long-chain fatty acids for beta-oxidation.	long-chain fatty acids	105-127	carnitine palmitoyltransferase 1A	Homo sapiens	17-50
30016793-1	2018	BACKGROUND/AIMS: Carnitine palmitoyltransferase 1A (CPT1A) is a rate-limiting enzyme in the transport of long-chain fatty acids for beta-oxidation.	long-chain fatty acids	105-127	carnitine palmitoyltransferase 1A	Homo sapiens	52-57
30785686-6	2018	In the later stages of phylogenesis, insulin initiated: a) the transformation of carnivorous ancestors of the species Homo sapiens in the ocean into a herbivorous species while living on land; b) the formation of the new biological function of locomotion and c) the dominance of the oleic variant of the metabolism of long-chain fatty acids with higher kinetic parameters of mitochondria oxidation.	long-chain fatty acids	318-340	insulin	Homo sapiens	37-44
29469952-1	2018	ABCD1 is a gene responsible for X-linked adrenoleukodystrophy (X-ALD), and is critical for the transport of very long-chain fatty acids (VLCFA) into peroxisomes and subsequent beta-oxidation.	long-chain fatty acids	113-135	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	0-5
29458843-1	2018	Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae.	long-chain fatty acids	86-108	fatty acid elongase ELO2	Saccharomyces cerevisiae S288C	10-14
29458843-1	2018	Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae.	long-chain fatty acids	86-108	fatty acid elongase ELO2	Saccharomyces cerevisiae S288C	15-19
29458843-1	2018	Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae.	long-chain fatty acids	86-108	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	24-28
29458843-1	2018	Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae.	long-chain fatty acids	86-108	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	29-33
29458843-1	2018	Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae.	long-chain fatty acids	125-147	fatty acid elongase ELO2	Saccharomyces cerevisiae S288C	10-14
29458843-1	2018	Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae.	long-chain fatty acids	125-147	fatty acid elongase ELO2	Saccharomyces cerevisiae S288C	15-19
29458843-1	2018	Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae.	long-chain fatty acids	125-147	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	24-28
29458843-1	2018	Elongases FEN1/ELO2 and SUR4/ELO3 are important enzymes involved in the elongation of long-chain fatty acids (LCFAs) to very long-chain fatty acids (VLCFAs) in Saccharomyces cerevisiae.	long-chain fatty acids	125-147	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	29-33
29458843-12	2018	The data suggest that the very long-chain fatty acids elongases ELO2 and ELO3 play important roles in lipotoxic cell death induced by OLA through maintaining a balanced FA composition in plasma membrane.	long-chain fatty acids	31-53	fatty acid elongase ELO2	Saccharomyces cerevisiae S288C	64-68
29458843-12	2018	The data suggest that the very long-chain fatty acids elongases ELO2 and ELO3 play important roles in lipotoxic cell death induced by OLA through maintaining a balanced FA composition in plasma membrane.	long-chain fatty acids	31-53	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	73-77
29459657-4	2018	Experiments using the NOX2-specific inhibitor Phox-I2 suggest that NOX2 is activated by accumulating long-chain fatty acids and generates ROS, which in turn changes mitochondrial morphology and activity.	long-chain fatty acids	101-123	cytochrome b-245 beta chain	Homo sapiens	22-26
29459657-4	2018	Experiments using the NOX2-specific inhibitor Phox-I2 suggest that NOX2 is activated by accumulating long-chain fatty acids and generates ROS, which in turn changes mitochondrial morphology and activity.	long-chain fatty acids	101-123	cytochrome b-245 beta chain	Homo sapiens	67-71
29433421-3	2018	CPT1A encodes a protein that imports long-chain fatty acids into the mitochondria for fatty-acid oxidation.	long-chain fatty acids	37-59	carnitine palmitoyltransferase 1A	Homo sapiens	0-5
29321392-1	2018	G-protein-coupled receptor 40 (GPR40)/free fatty acid receptor (FFAR) 1 is activated by long-chain fatty acids such as docosahexaenoic acid (DHA).	long-chain fatty acids	88-110	free fatty acid receptor 1	Homo sapiens	31-36
28364190-11	2017	Moreover, PTE inhibited VAT inflammation by simultaneously downregulating inflammatory molecules and inducing expression of Gpr120 that encodes an anti-inflammatory and pro-adipogenesis receptor (GPR-120) that recognizes unsaturated long-chain fatty acids, including DNL products.	long-chain fatty acids	233-255	free fatty acid receptor 4	Mus musculus	124-130
28364190-11	2017	Moreover, PTE inhibited VAT inflammation by simultaneously downregulating inflammatory molecules and inducing expression of Gpr120 that encodes an anti-inflammatory and pro-adipogenesis receptor (GPR-120) that recognizes unsaturated long-chain fatty acids, including DNL products.	long-chain fatty acids	233-255	free fatty acid receptor 4	Mus musculus	196-203
29089175-2	2017	The disease is caused by mutations in ABCD1 and characterized by very long-chain fatty acids (VLCFA) accumulation.	long-chain fatty acids	70-92	ATP binding cassette subfamily D member 1	Homo sapiens	38-43
29059709-4	2017	Because mutations in ABCD1 lead to incorporation of very-long-chain fatty acids into phospholipids, we separately examined the effects of lysophosphatidylcholine (LPC) upon microglia.	long-chain fatty acids	57-79	ATP binding cassette subfamily D member 1	Homo sapiens	21-26
28824022-1	2017	GPR120 is a G-protein-coupled receptor that is activated by long-chain fatty acids.	long-chain fatty acids	60-82	free fatty acid receptor 4	Mus musculus	0-6
28916721-3	2017	CPT2 loss in heart and muscle reduced complete oxidation of long-chain fatty acids by 87 and 69%, respectively, without altering body weight, energy expenditure, respiratory quotient, or adiposity.	long-chain fatty acids	60-82	carnitine palmitoyltransferase 2	Mus musculus	0-4
28911862-2	2017	Fabp5 is a cytoplasmic protein that binds long-chain fatty acids and other lipophilic ligands.	long-chain fatty acids	42-64	fatty acid binding protein 5	Homo sapiens	0-5
29151954-3	2017	In this study, we showed that expression of carnitine palmitoyltransferase 1C (Cpt1c), as a member of the gate-keeper enzymes , which transferring long-chain fatty acids into mitochondria to further oxidation, which is regulated by AMPK promotes papillary thyroid carcinomas cells survival under metabolic stress conditions.	long-chain fatty acids	147-169	carnitine palmitoyltransferase 1C	Homo sapiens	44-77
29151954-3	2017	In this study, we showed that expression of carnitine palmitoyltransferase 1C (Cpt1c), as a member of the gate-keeper enzymes , which transferring long-chain fatty acids into mitochondria to further oxidation, which is regulated by AMPK promotes papillary thyroid carcinomas cells survival under metabolic stress conditions.	long-chain fatty acids	147-169	carnitine palmitoyltransferase 1C	Homo sapiens	79-84
29151954-3	2017	In this study, we showed that expression of carnitine palmitoyltransferase 1C (Cpt1c), as a member of the gate-keeper enzymes , which transferring long-chain fatty acids into mitochondria to further oxidation, which is regulated by AMPK promotes papillary thyroid carcinomas cells survival under metabolic stress conditions.	long-chain fatty acids	147-169	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	232-236
28601575-2	2017	The disease is the consequence of mutations in the ABCD1 gene that encodes the peroxisomal membrane protein ALDP which is involved in the transmembrane transport of very long-chain fatty acids.	long-chain fatty acids	170-192	ATP binding cassette subfamily D member 1	Homo sapiens	51-56
29152099-2	2017	It is a heterogeneous disorder caused by mutations in the ATP-binding cassette protein subfamily D1 (ABCD1) gene, encoding the peroxisomal membrane protein ALDP, which is involved in the transmembrane transport of very long-chain fatty acids.	long-chain fatty acids	219-241	ATP binding cassette subfamily D member 1	Homo sapiens	101-106
29152099-2	2017	It is a heterogeneous disorder caused by mutations in the ATP-binding cassette protein subfamily D1 (ABCD1) gene, encoding the peroxisomal membrane protein ALDP, which is involved in the transmembrane transport of very long-chain fatty acids.	long-chain fatty acids	219-241	ATP binding cassette subfamily D member 1	Homo sapiens	156-160
28601575-2	2017	The disease is the consequence of mutations in the ABCD1 gene that encodes the peroxisomal membrane protein ALDP which is involved in the transmembrane transport of very long-chain fatty acids.	long-chain fatty acids	170-192	ATP binding cassette subfamily D member 1	Homo sapiens	108-112
28450226-3	2017	In this study, we found that long-chain fatty acids and their CoA ester derivatives inhibit CBR1.	long-chain fatty acids	29-51	carbonyl reductase 1	Homo sapiens	92-96
28734639-1	2017	Free Fatty Acid receptor 4 (FFA4), also known as GPR120, is a G-protein-coupled receptor (GPCR) responsive to long-chain fatty acids that is attracting considerable attention as a potential novel therapeutic target for the treatment of type 2 diabetes mellitus (T2DM).	long-chain fatty acids	110-132	free fatty acid receptor 4	Homo sapiens	0-26
28734639-1	2017	Free Fatty Acid receptor 4 (FFA4), also known as GPR120, is a G-protein-coupled receptor (GPCR) responsive to long-chain fatty acids that is attracting considerable attention as a potential novel therapeutic target for the treatment of type 2 diabetes mellitus (T2DM).	long-chain fatty acids	110-132	free fatty acid receptor 4	Homo sapiens	28-32
28734639-1	2017	Free Fatty Acid receptor 4 (FFA4), also known as GPR120, is a G-protein-coupled receptor (GPCR) responsive to long-chain fatty acids that is attracting considerable attention as a potential novel therapeutic target for the treatment of type 2 diabetes mellitus (T2DM).	long-chain fatty acids	110-132	free fatty acid receptor 4	Homo sapiens	49-55
28482236-7	2017	The global hypothalamic metabolomic results revealed that depletion of BCO2 resulted in striking metabolic changes, including suppression of long-chain fatty acids transport into mitochondria, inhibition of the metabolism of dipeptides and sulfur-containing amino acids, and stimulation of local oxidative stress and inflammation in the hypothalamus of BCO2 KO mice.	long-chain fatty acids	141-163	beta-carotene oxygenase 2	Mus musculus	71-75
28125087-1	2017	Carnitine palmitoyltransferase 1 isoform A (CPT1A) is a crucial enzyme for the transport of long-chain fatty acids into the mitochondria.	long-chain fatty acids	92-114	carnitine palmitoyltransferase 1A	Homo sapiens	0-42
28125087-1	2017	Carnitine palmitoyltransferase 1 isoform A (CPT1A) is a crucial enzyme for the transport of long-chain fatty acids into the mitochondria.	long-chain fatty acids	92-114	carnitine palmitoyltransferase 1A	Homo sapiens	44-49
27041118-1	2017	X-linked adrenoleukodystrophy (X-ALD) is a genetic disorder induced by a mutation in the ABCD1 gene, which causes the accumulation of very long-chain fatty acids in tissue and plasma.	long-chain fatty acids	139-161	ATP binding cassette subfamily D member 1	Homo sapiens	89-94
28737695-2	2017	Defective ABCD1 leads to the accumulation of very long-chain fatty acids and is associated with a complex and severe neurodegenerative disorder called X-linked adrenoleukodystrophy (X-ALD).	long-chain fatty acids	50-72	ATP binding cassette subfamily D member 1	Homo sapiens	10-15
28955759-1	2017	Adipocyte fatty acid-binding protein (AFABP: FABP4) is a member of the intracellular lipid-binding protein family that is thought to target long-chain fatty acids to nuclear receptors such as peroxisome proliferator-activated receptor gamma (PPARgamma), which in turn plays roles in insulin resistance and obesity.	long-chain fatty acids	140-162	fatty acid binding protein 4	Homo sapiens	38-43
28955759-1	2017	Adipocyte fatty acid-binding protein (AFABP: FABP4) is a member of the intracellular lipid-binding protein family that is thought to target long-chain fatty acids to nuclear receptors such as peroxisome proliferator-activated receptor gamma (PPARgamma), which in turn plays roles in insulin resistance and obesity.	long-chain fatty acids	140-162	fatty acid binding protein 4	Homo sapiens	45-50
28955759-1	2017	Adipocyte fatty acid-binding protein (AFABP: FABP4) is a member of the intracellular lipid-binding protein family that is thought to target long-chain fatty acids to nuclear receptors such as peroxisome proliferator-activated receptor gamma (PPARgamma), which in turn plays roles in insulin resistance and obesity.	long-chain fatty acids	140-162	peroxisome proliferator activated receptor gamma	Homo sapiens	192-240
28955759-1	2017	Adipocyte fatty acid-binding protein (AFABP: FABP4) is a member of the intracellular lipid-binding protein family that is thought to target long-chain fatty acids to nuclear receptors such as peroxisome proliferator-activated receptor gamma (PPARgamma), which in turn plays roles in insulin resistance and obesity.	long-chain fatty acids	140-162	peroxisome proliferator activated receptor gamma	Homo sapiens	242-251
28955759-1	2017	Adipocyte fatty acid-binding protein (AFABP: FABP4) is a member of the intracellular lipid-binding protein family that is thought to target long-chain fatty acids to nuclear receptors such as peroxisome proliferator-activated receptor gamma (PPARgamma), which in turn plays roles in insulin resistance and obesity.	long-chain fatty acids	140-162	insulin	Homo sapiens	283-290
28330968-1	2017	Carnitine palmitoyltransferase 1 (CPT1) is essential for the transport of long-chain fatty acids into the mitochondria for oxidation.	long-chain fatty acids	74-96	carnitine palmitoyltransferase 1b, muscle	Mus musculus	34-38
27799409-10	2017	Our studies showed that ACBD5 deficiency leads to accumulation of very long-chain fatty acids (VLCFAs) due to impaired peroxisomal beta-oxidation.	long-chain fatty acids	71-93	acyl-CoA binding domain containing 5	Homo sapiens	24-29
28436449-8	2017	The decreased activity of the desaturase FADS1 appeared as a bottleneck, leading upstream to an accumulation of fatty acids and downstream to a deficiency of long-chain fatty acids resulting to impaired phospholipid synthesis.	long-chain fatty acids	158-180	fatty acid desaturase 1	Homo sapiens	41-46
28132807-2	2017	Acyl-CoA synthetase long-chain family member 1 (ACSL1) is required for thioesterification of long-chain fatty acids into their acyl-CoA derivatives.	long-chain fatty acids	93-115	acyl-CoA synthetase long chain family member 1	Homo sapiens	0-46
28571184-3	2017	Liver- Fatty Acid Binding Protein (L-FABP) is a small protein that is abundant in hepatocytes, and which binds most of the long-chain fatty acids present in the cytosol.	long-chain fatty acids	123-145	fatty acid binding protein 1	Homo sapiens	0-33
28571184-3	2017	Liver- Fatty Acid Binding Protein (L-FABP) is a small protein that is abundant in hepatocytes, and which binds most of the long-chain fatty acids present in the cytosol.	long-chain fatty acids	123-145	fatty acid binding protein 1	Homo sapiens	35-41
28132807-2	2017	Acyl-CoA synthetase long-chain family member 1 (ACSL1) is required for thioesterification of long-chain fatty acids into their acyl-CoA derivatives.	long-chain fatty acids	93-115	acyl-CoA synthetase long chain family member 1	Homo sapiens	48-53
28153718-6	2017	Given that HADHA catalyzes the last three steps of mitochondrial beta-oxidation of long-chain fatty acids, we investigated whether long-chain fatty acids induce autophagy in IECs.	long-chain fatty acids	83-105	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	11-16
28107461-1	2017	Fatty acid synthase (FASN) is an enzyme responsible for the de novo synthesis of long-chain fatty acids.	long-chain fatty acids	81-103	fatty acid synthase	Sus scrofa	0-19
27986444-9	2017	We also examine mechanistic studies suggesting that omega3-PUFAs signal through free fatty acid receptor 4 (Ffar4), a G-protein coupled receptor (GPR) for long-chain fatty acids (FA), thereby identifying an entirely novel mechanism of action for omega3-PUFA mediated cardioprotection.	long-chain fatty acids	155-177	free fatty acid receptor 4	Homo sapiens	80-106
27986444-9	2017	We also examine mechanistic studies suggesting that omega3-PUFAs signal through free fatty acid receptor 4 (Ffar4), a G-protein coupled receptor (GPR) for long-chain fatty acids (FA), thereby identifying an entirely novel mechanism of action for omega3-PUFA mediated cardioprotection.	long-chain fatty acids	155-177	free fatty acid receptor 4	Homo sapiens	108-113
27986444-9	2017	We also examine mechanistic studies suggesting that omega3-PUFAs signal through free fatty acid receptor 4 (Ffar4), a G-protein coupled receptor (GPR) for long-chain fatty acids (FA), thereby identifying an entirely novel mechanism of action for omega3-PUFA mediated cardioprotection.	long-chain fatty acids	155-177	lysophosphatidic acid receptor 2	Homo sapiens	118-144
27986444-9	2017	We also examine mechanistic studies suggesting that omega3-PUFAs signal through free fatty acid receptor 4 (Ffar4), a G-protein coupled receptor (GPR) for long-chain fatty acids (FA), thereby identifying an entirely novel mechanism of action for omega3-PUFA mediated cardioprotection.	long-chain fatty acids	155-177	lysophosphatidic acid receptor 2	Homo sapiens	146-149
27984203-3	2017	Classic biochemical studies revealed the general principle of adaptive thermogenesis: in the presence of long-chain fatty acids (FA), UCP1 increases the permeability of the inner mitochondrial membrane for H+, which makes brown fat mitochondria produce heat rather than ATP.	long-chain fatty acids	105-127	uncoupling protein 1	Homo sapiens	134-138
28107461-1	2017	Fatty acid synthase (FASN) is an enzyme responsible for the de novo synthesis of long-chain fatty acids.	long-chain fatty acids	81-103	fatty acid synthase	Sus scrofa	21-25
28117025-1	2017	BACKGROUND: GPR40, an orphan G-protein coupled receptor that is activated by medium and long-chain fatty acids and is highly expressed in pancreatic islets, adipose depots and the gastrointestinal tract are involved in energy source recognition, absorption, storage and/or metabolism.	long-chain fatty acids	88-110	free fatty acid receptor 1	Homo sapiens	12-17
27757764-2	2017	Among them, FFA1 (GPR40) and FFA4 (GPR120) bind long-chain fatty acids, FFA2 (GPR43) and FFA3 (GPR41) bind short-chain fatty acids and GPR84 binds medium-chain fatty acids.	long-chain fatty acids	48-70	free fatty acid receptor 1	Homo sapiens	18-23
27757764-2	2017	Among them, FFA1 (GPR40) and FFA4 (GPR120) bind long-chain fatty acids, FFA2 (GPR43) and FFA3 (GPR41) bind short-chain fatty acids and GPR84 binds medium-chain fatty acids.	long-chain fatty acids	48-70	free fatty acid receptor 4	Homo sapiens	35-41
27807695-1	2017	The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders.	long-chain fatty acids	114-136	free fatty acid receptor 4	Homo sapiens	53-59
27807695-1	2017	The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders.	long-chain fatty acids	114-136	insulin	Homo sapiens	206-213
27807695-1	2017	The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders.	long-chain fatty acids	114-136	insulin	Homo sapiens	236-243
27980502-7	2017	The major changes of the metabolite profiles following G-CSF administration included alteration of several fatty acids, including increased levels of several medium and long-chain fatty acids, as well as polyunsaturated fatty acids; while there were lower levels of other lipid metabolites such as phospholipids, lysolipids, sphingolipids.	long-chain fatty acids	169-191	colony stimulating factor 3	Homo sapiens	55-60
27819726-2	2016	It is shown here that HSD17B4, a bifunctional enzyme mediating dehydrogenation and anhydration during beta-oxidation of long-chain fatty acids, contains a non-synonymous SNP (nsSNP) of chr2:128,825,976A>G, c.2137A>G, I690V, within the sterol carrier protein-2 domain of the HSD17B4 gene, by RNA-Seq of liver RNA.	long-chain fatty acids	120-142	hydroxysteroid 17-beta dehydrogenase 4	Sus scrofa	22-29
28154332-2	2017	Recently, it has been determined that G-protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFA1) is activated by long-chain fatty acids, such as docosahexaenoic acid (DHA).	long-chain fatty acids	124-146	free fatty acid receptor 1	Homo sapiens	96-101
28154332-9	2017	Our findings suggest that brain free long-chain fatty acids-GPR40/FFA1 signaling might have an important role in the modulation of endogenous pain control systems.	long-chain fatty acids	37-59	free fatty acid receptor 1	Homo sapiens	60-65
27758871-1	2016	Previous research has indicated that long-chain fatty acids can bind myoglobin (Mb) in an oxygen-dependent manner.	long-chain fatty acids	37-59	myoglobin	Homo sapiens	69-78
27758871-1	2016	Previous research has indicated that long-chain fatty acids can bind myoglobin (Mb) in an oxygen-dependent manner.	long-chain fatty acids	37-59	myoglobin	Homo sapiens	80-82
28606572-9	2017	RESULTS: Serum DAO activity in both phases was positively correlated with intake of long-chain fatty acids, saturated fatty acids, and monounsaturated fatty acids (P < 0.05).	long-chain fatty acids	84-106	amine oxidase copper containing 1	Homo sapiens	15-18
27793673-1	2016	A high-throughput RapidFire mass spectrometry assay is described for elongation of very long-chain fatty acids family 6 (Elovl6).	long-chain fatty acids	88-110	ELOVL fatty acid elongase 6	Homo sapiens	121-127
27819726-2	2016	It is shown here that HSD17B4, a bifunctional enzyme mediating dehydrogenation and anhydration during beta-oxidation of long-chain fatty acids, contains a non-synonymous SNP (nsSNP) of chr2:128,825,976A>G, c.2137A>G, I690V, within the sterol carrier protein-2 domain of the HSD17B4 gene, by RNA-Seq of liver RNA.	long-chain fatty acids	120-142	hydroxysteroid 17-beta dehydrogenase 4	Sus scrofa	280-287
27779191-1	2016	X-linked adrenoleukodystrophy (X-ALD), caused by an ABCD1 mutation, is a progressive neurodegenerative disorder associated with the accumulation of very long-chain fatty acids (VLCFA).	long-chain fatty acids	153-175	ATP binding cassette subfamily D member 1	Homo sapiens	52-57
27647366-1	2016	The free fatty acid receptor 1 (FFA1), a G protein-coupled receptor (GPCR) naturally activated by long-chain fatty acids is a novel target for the treatment of metabolic diseases.	long-chain fatty acids	98-120	free fatty acid receptor 1	Mus musculus	4-30
27647366-1	2016	The free fatty acid receptor 1 (FFA1), a G protein-coupled receptor (GPCR) naturally activated by long-chain fatty acids is a novel target for the treatment of metabolic diseases.	long-chain fatty acids	98-120	free fatty acid receptor 1	Mus musculus	32-36
27189022-8	2016	In conclusion, we identified the functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping, as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Delta20 molecules, a mitochondrial located enzyme, is involved in migraine pathology.	long-chain fatty acids	211-233	acyl-CoA synthetase long chain family member 5	Homo sapiens	81-86
27189022-8	2016	In conclusion, we identified the functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping, as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Delta20 molecules, a mitochondrial located enzyme, is involved in migraine pathology.	long-chain fatty acids	211-233	acyl-CoA synthetase long chain family member 5	Homo sapiens	249-254
27425035-0	2016	CYP4F2 affects phenotypic outcome in adrenoleukodystrophy by modulating the clearance of very long-chain fatty acids.	long-chain fatty acids	94-116	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	0-6
27425035-1	2016	X-linked adrenoleukodystrophy (ALD) is a severe neurodegenerative disorder caused by the accumulation of very long-chain fatty acids (VLCFA) due to mutations in the ABCD1 gene.	long-chain fatty acids	110-132	ATP binding cassette subfamily D member 1	Homo sapiens	165-170
27412859-1	2016	The intracellular serine amidase, fatty acid amide hydrolase (FAAH), degrades a heterogeneous family of lipid-derived bioactive molecules that include amides of long-chain fatty acids with taurine [N-acyl-taurines (NATs)].	long-chain fatty acids	161-183	fatty acid amide hydrolase	Homo sapiens	34-60
27077479-5	2016	MEASUREMENTS AND MAIN RESULTS: By metabolomics analysis, we found an increase in long-chain fatty acids in BMPR2 mutant mouse RVs compared with controls, which correlated with cardiac index.	long-chain fatty acids	81-103	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Mus musculus	107-112
27312864-2	2016	ALD is caused by mutations in the ABCD1 gene, which leads to the accumulation of very long-chain fatty acids in plasma and tissues.	long-chain fatty acids	86-108	ATP binding cassette subfamily D member 1	Homo sapiens	34-39
27363707-2	2016	Long-chain fatty acids bind free fatty acid receptor (FFAR)-1/GPR40, which is expressed on bovine neutrophils, and increase responses such as granule release and gene expression.	long-chain fatty acids	0-22	free fatty acid receptor 1	Bos taurus	54-61
27412859-1	2016	The intracellular serine amidase, fatty acid amide hydrolase (FAAH), degrades a heterogeneous family of lipid-derived bioactive molecules that include amides of long-chain fatty acids with taurine [N-acyl-taurines (NATs)].	long-chain fatty acids	161-183	fatty acid amide hydrolase	Homo sapiens	62-66
27241966-1	2016	X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene and leads to an elevation of very-long-chain fatty acids (VLCFA).	long-chain fatty acids	113-135	ATP binding cassette subfamily D member 1	Homo sapiens	68-73
27143115-1	2016	INTRODUCTION: SCA38 (MIM 611805) caused by mutations within the ELOVL5 gene, which encodes an enzyme involved in the synthesis of long-chain fatty acids with a high and specific expression in Purkinje cells, has recently been identified.	long-chain fatty acids	130-152	ELOVL fatty acid elongase 5	Homo sapiens	14-19
27143115-1	2016	INTRODUCTION: SCA38 (MIM 611805) caused by mutations within the ELOVL5 gene, which encodes an enzyme involved in the synthesis of long-chain fatty acids with a high and specific expression in Purkinje cells, has recently been identified.	long-chain fatty acids	130-152	ELOVL fatty acid elongase 5	Homo sapiens	64-70
27008858-3	2016	Mfsd2a is a newly described sodium-dependent lysophosphatidylcholine (LPC) symporter expressed at the blood-brain barrier that transports LPCs containing DHA and other long-chain fatty acids.	long-chain fatty acids	168-190	major facilitator superfamily domain containing 2A	Mus musculus	0-6
27160910-4	2016	We find that mutated EHHADH is incorporated into mitochondrial trifunctional protein (MTP), thereby disturbing beta-oxidation of long-chain fatty acids.	long-chain fatty acids	129-151	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Homo sapiens	21-27
27160910-4	2016	We find that mutated EHHADH is incorporated into mitochondrial trifunctional protein (MTP), thereby disturbing beta-oxidation of long-chain fatty acids.	long-chain fatty acids	129-151	microsomal triglyceride transfer protein	Homo sapiens	49-84
27160910-4	2016	We find that mutated EHHADH is incorporated into mitochondrial trifunctional protein (MTP), thereby disturbing beta-oxidation of long-chain fatty acids.	long-chain fatty acids	129-151	microsomal triglyceride transfer protein	Homo sapiens	86-89
26910791-4	2016	Fatty acid synthase (FASN) catalyzes the de novo synthesis of long-chain fatty acids from acetyl-coenzyme A and malonyl-coenzyme A.	long-chain fatty acids	62-84	fatty acid synthase	Mus musculus	0-19
26910791-4	2016	Fatty acid synthase (FASN) catalyzes the de novo synthesis of long-chain fatty acids from acetyl-coenzyme A and malonyl-coenzyme A.	long-chain fatty acids	62-84	fatty acid synthase	Mus musculus	21-25
26898284-9	2016	Different from effects on fatty acid composition, effects of the DGAT1 polymorphism on yields of long-chain fatty acids C18:1 cis-9, CLA cis-9,trans-11, C18:2 cis-9,cis-12, and C18:3 cis-9,cis-12,cis-15 were not significant.	long-chain fatty acids	97-119	diacylglycerol O-acyltransferase 1	Bos taurus	65-70
26799588-2	2016	Carnitine palmitoyl transferase I (CPT1) is the rate-limiting enzyme in the transport of long-chain fatty acids for beta-oxidation.	long-chain fatty acids	89-111	carnitine palmitoyltransferase 1A	Homo sapiens	35-39
26853521-1	2016	Here, we assessed the effects of long-chain fatty acids (LCFAs) and the LCFA receptor agonist GW9508 on the transcription of the gonadotropin subunit genes Cga, Lhb and Fshb because LCFA receptor GPR120 was observed in mouse gonadotropes in our recent study.	long-chain fatty acids	33-55	chromogranin A	Mus musculus	156-159
26853521-1	2016	Here, we assessed the effects of long-chain fatty acids (LCFAs) and the LCFA receptor agonist GW9508 on the transcription of the gonadotropin subunit genes Cga, Lhb and Fshb because LCFA receptor GPR120 was observed in mouse gonadotropes in our recent study.	long-chain fatty acids	33-55	luteinizing hormone beta	Mus musculus	161-164
26853521-1	2016	Here, we assessed the effects of long-chain fatty acids (LCFAs) and the LCFA receptor agonist GW9508 on the transcription of the gonadotropin subunit genes Cga, Lhb and Fshb because LCFA receptor GPR120 was observed in mouse gonadotropes in our recent study.	long-chain fatty acids	33-55	follicle stimulating hormone beta	Mus musculus	169-173
26739335-4	2016	GPR40 and GPR120 are activated by long-chain fatty acids (>C12) with both receptors coupling to the Galphaq subunit that activates the Ca(2+)-dependent pathway.	long-chain fatty acids	34-56	free fatty acid receptor 1	Homo sapiens	0-5
26739335-4	2016	GPR40 and GPR120 are activated by long-chain fatty acids (>C12) with both receptors coupling to the Galphaq subunit that activates the Ca(2+)-dependent pathway.	long-chain fatty acids	34-56	free fatty acid receptor 4	Homo sapiens	10-16
26739335-4	2016	GPR40 and GPR120 are activated by long-chain fatty acids (>C12) with both receptors coupling to the Galphaq subunit that activates the Ca(2+)-dependent pathway.	long-chain fatty acids	34-56	G protein subunit alpha q	Homo sapiens	103-110
26991015-0	2016	High incorporation of long-chain fatty acids contributes to the efficient production of acylated ghrelin in ghrelin-producing cells.	long-chain fatty acids	22-44	ghrelin	Mus musculus	97-104
26991015-0	2016	High incorporation of long-chain fatty acids contributes to the efficient production of acylated ghrelin in ghrelin-producing cells.	long-chain fatty acids	22-44	ghrelin	Mus musculus	108-115
26991015-2	2016	We found that long-chain fatty acids were incorporated at a higher rate in the ghrelin-producing cell line MGN3-1 than in MIN6 cells, in part due to higher expression level of long-chain fatty acyl-CoA synthetase family member 1 (Acsl1).	long-chain fatty acids	14-36	ghrelin	Mus musculus	79-86
26991015-2	2016	We found that long-chain fatty acids were incorporated at a higher rate in the ghrelin-producing cell line MGN3-1 than in MIN6 cells, in part due to higher expression level of long-chain fatty acyl-CoA synthetase family member 1 (Acsl1).	long-chain fatty acids	14-36	acyl-CoA synthetase long-chain family member 1	Mus musculus	193-228
26991015-2	2016	We found that long-chain fatty acids were incorporated at a higher rate in the ghrelin-producing cell line MGN3-1 than in MIN6 cells, in part due to higher expression level of long-chain fatty acyl-CoA synthetase family member 1 (Acsl1).	long-chain fatty acids	14-36	acyl-CoA synthetase long-chain family member 1	Mus musculus	230-235
26991015-4	2016	These results suggest that high incorporation of long-chain fatty acids into the ghrelin-producing cells plays a role in the supply of octanoic acid for ghrelin acylation.	long-chain fatty acids	49-71	ghrelin	Mus musculus	81-88
26991015-4	2016	These results suggest that high incorporation of long-chain fatty acids into the ghrelin-producing cells plays a role in the supply of octanoic acid for ghrelin acylation.	long-chain fatty acids	49-71	ghrelin	Mus musculus	153-160
26898284-9	2016	Different from effects on fatty acid composition, effects of the DGAT1 polymorphism on yields of long-chain fatty acids C18:1 cis-9, CLA cis-9,trans-11, C18:2 cis-9,cis-12, and C18:3 cis-9,cis-12,cis-15 were not significant.	long-chain fatty acids	97-119	complement C9	Bos taurus	120-131
26898284-9	2016	Different from effects on fatty acid composition, effects of the DGAT1 polymorphism on yields of long-chain fatty acids C18:1 cis-9, CLA cis-9,trans-11, C18:2 cis-9,cis-12, and C18:3 cis-9,cis-12,cis-15 were not significant.	long-chain fatty acids	97-119	complement C9	Bos taurus	177-188
26898284-10	2016	This indicates that effects of DGAT1 on these fatty acids are indirect, not direct, effects: DGAT1 affects de novo synthesis of fatty acids and, consequently, the contribution of the long-chain fatty acids to total fat is decreased.	long-chain fatty acids	183-205	diacylglycerol O-acyltransferase 1	Bos taurus	31-36
26898284-10	2016	This indicates that effects of DGAT1 on these fatty acids are indirect, not direct, effects: DGAT1 affects de novo synthesis of fatty acids and, consequently, the contribution of the long-chain fatty acids to total fat is decreased.	long-chain fatty acids	183-205	diacylglycerol O-acyltransferase 1	Bos taurus	93-98
26828581-1	2016	PURPOSE OF REVIEW: Endogenous synthesis of the long-chain polyunsaturated fatty acids (LCPUFAs) is mediated by the fatty acid desaturase (FADS) gene cluster (11q12-13.1) and elongation of very long-chain fatty acids 2 (ELOVL2) (6p24.2) and ELOVL5 (6p12.1).	long-chain fatty acids	193-215	stearoyl-CoA desaturase	Homo sapiens	115-136
26812986-8	2016	Recent data indicate the possibility of nutrigenomic interventions to increase milk fat synthesis by feeding long-chain fatty acids and milk protein synthesis by feeding amino acids.	long-chain fatty acids	109-131	Weaning weight-maternal milk	Bos taurus	79-83
26680361-2	2016	FAS synthesizes long-chain fatty acids from three substrates: acetyl-CoA as a primer, malonyl-CoA as a 2 carbon donor, and NADPH for reduction.	long-chain fatty acids	16-38	fatty acid synthase	Homo sapiens	0-3
26828581-1	2016	PURPOSE OF REVIEW: Endogenous synthesis of the long-chain polyunsaturated fatty acids (LCPUFAs) is mediated by the fatty acid desaturase (FADS) gene cluster (11q12-13.1) and elongation of very long-chain fatty acids 2 (ELOVL2) (6p24.2) and ELOVL5 (6p12.1).	long-chain fatty acids	193-215	stearoyl-CoA desaturase	Homo sapiens	138-142
26881707-3	2016	Since binding affinities of long-chain fatty acids exceed those of plasma Zn2+, this means that under certain circumstances the binding of fatty acid molecules to HSA is likely to diminish HSA Zn2+-binding, and hence affects the control of circulatory and cellular Zn2+ dynamics.	long-chain fatty acids	28-50	albumin	Homo sapiens	163-166
26902786-1	2016	Mitochondrial aspartate aminotransferase (mAspAT) was recognized as a moonlighting enzyme because it has not only aminotransferase activity but also a high-affinity long-chain fatty acids (LCFA) binding site.	long-chain fatty acids	165-187	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	42-48
27030498-1	2016	OBJECTIVE: To investigate the expression of elongation of very long-chain fatty acids family member 6 (ELOVL6) in high-grade serous ovarian carcinoma (HSOC), and explore the correlation between its expression and clinical prognosis in these patients.	long-chain fatty acids	63-85	ELOVL fatty acid elongase 6	Homo sapiens	103-109
26798409-8	2016	CPT1A holds a cardinal position in the metabolism of long-chain fatty acids while ABCG1 plays a role in triglyceride metabolism.	long-chain fatty acids	53-75	carnitine palmitoyltransferase 1A	Homo sapiens	0-5
26881707-3	2016	Since binding affinities of long-chain fatty acids exceed those of plasma Zn2+, this means that under certain circumstances the binding of fatty acid molecules to HSA is likely to diminish HSA Zn2+-binding, and hence affects the control of circulatory and cellular Zn2+ dynamics.	long-chain fatty acids	28-50	albumin	Homo sapiens	189-192
27117849-2	2016	Medium-chain fatty acids (MCFAs) have anti-obesogenic effects in rodents and humans, while long-chain fatty acids (LCFAs) cause increases in body weight and insulin resistance.	long-chain fatty acids	91-113	insulin	Homo sapiens	157-164
27272436-3	2016	High long-chain fatty acids-low phytosterols (HLLP) SPS >= 750 nM with testosterone significantly increased and >=500 nM with dihydrotestosterone significantly decreased LNCaP cell number.	long-chain fatty acids	5-27	LLP homolog, long-term synaptic facilitation factor	Homo sapiens	46-50
26517907-3	2015	ABCD1 performs transport of coenzyme A esters of very-long-chain fatty acids (VLCFA) in peroxisomes and a number of mutations in ABCD1 gene were linked to an X-linked adrenoleucodystrophy (X-ALD).	long-chain fatty acids	54-76	ATP binding cassette subfamily D member 1	Homo sapiens	0-5
26370417-4	2015	Though ABCD1 codes for a peroxisomal transporter of very long-chain fatty acids, the molecular mechanisms that govern disease onset and progression, or its transformation to a cerebral, inflammatory demyelinating form, remain largely unknown.	long-chain fatty acids	57-79	ATP binding cassette subfamily D member 1	Homo sapiens	7-12
26668261-5	2015	Deletion of gspD or gspE in A. baumannii ATCC 17978 results in loss of secretion of LipA, a lipase that breaks down long-chain fatty acids.	long-chain fatty acids	116-138	lysosomal acid lipase A	Mus musculus	84-88
26668261-6	2015	Due to a lack of extracellular lipase, the gspD mutant, the gspE mutant, and a lipA deletion strain are incapable of growth on long-chain fatty acids as a sole source of carbon, while their growth characteristics are indistinguishable from those of the wild-type strain in nutrient-rich broth.	long-chain fatty acids	127-149	lysosomal acid lipase A	Mus musculus	79-83
26708865-2	2016	CPT1A and CPT1B were identified as the gate-keeper enzymes for the entry of long-chain fatty acids (as carnitine esters) into mitochondria and their further oxidation, and they show differences in their kinetics and tissue expression.	long-chain fatty acids	76-98	carnitine palmitoyltransferase 1A	Homo sapiens	0-5
26708865-2	2016	CPT1A and CPT1B were identified as the gate-keeper enzymes for the entry of long-chain fatty acids (as carnitine esters) into mitochondria and their further oxidation, and they show differences in their kinetics and tissue expression.	long-chain fatty acids	76-98	carnitine palmitoyltransferase 1B	Homo sapiens	10-15
26494228-4	2015	Therefore, we assessed whether PCSK9 enhances the degradation of CD36, a major receptor involved in transport of long-chain fatty acids and triglyceride storage.	long-chain fatty acids	113-135	proprotein convertase subtilisin/kexin type 9	Mus musculus	31-36
26417688-1	2015	G protein-coupled receptor 40 (GPR40) is predominantly expressed in pancreatic beta-cells and activated by long-chain fatty acids.	long-chain fatty acids	107-129	free fatty acid receptor 1	Rattus norvegicus	0-29
26417688-1	2015	G protein-coupled receptor 40 (GPR40) is predominantly expressed in pancreatic beta-cells and activated by long-chain fatty acids.	long-chain fatty acids	107-129	free fatty acid receptor 1	Rattus norvegicus	31-36
26488817-2	2015	We report that long-chain fatty acids (LCFAs) enhanced differentiation and proliferation of T helper 1 (Th1) and/or Th17 cells and impaired their intestinal sequestration via p38-MAPK pathway.	long-chain fatty acids	15-37	mitogen-activated protein kinase 14	Homo sapiens	175-178
26381015-3	2015	The G-protein-coupled receptor, FFAR1 (previously GPR40), expressed on L cells and activated by long-chain fatty acids (LCFAs) is a potential target.	long-chain fatty acids	96-118	free fatty acid receptor 1	Rattus norvegicus	50-55
26381015-3	2015	The G-protein-coupled receptor, FFAR1 (previously GPR40), expressed on L cells and activated by long-chain fatty acids (LCFAs) is a potential target.	long-chain fatty acids	96-118	free fatty acid receptor 1	Rattus norvegicus	32-37
26345771-3	2015	FASN (fatty acid synthase) plays an important role in de novo lipogenesis, through catalyzing the reductive synthesis of long-chain fatty acids.	long-chain fatty acids	121-143	fatty acid synthase	Sus scrofa	0-4
26026766-10	2015	Cows fed the HE diet also had greater expression of transcription factors involved in metabolism of long-chain fatty acids (PPARD, RXRA), suggesting that immune cells might be predisposed to use endogenous ligands such as nonesterified fatty acids available in the circulation when glucose is in high demand for milk synthesis.	long-chain fatty acids	100-122	peroxisome proliferator activated receptor delta	Bos taurus	124-129
26026766-10	2015	Cows fed the HE diet also had greater expression of transcription factors involved in metabolism of long-chain fatty acids (PPARD, RXRA), suggesting that immune cells might be predisposed to use endogenous ligands such as nonesterified fatty acids available in the circulation when glucose is in high demand for milk synthesis.	long-chain fatty acids	100-122	retinoid X receptor alpha	Bos taurus	131-135
26108543-2	2015	Little is known about the effects of long-chain fatty acids (LCFAs) on mucin 2 (MUC2) production by goblet cells, which are crucial for intestinal protection.	long-chain fatty acids	37-59	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	71-78
26711077-0	2015	[Study on the methylation of LCHAD gene promoter region in mitochondria of trophoblast cells incubated with long-chain fatty acids].	long-chain fatty acids	108-130	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	29-34
26711077-1	2015	OBJECTIVE: To explore the methylation level of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) gene promoter region in mitochondria of trophoblasts incubated with long-chain fatty acids and the time-effect of methylation modification.	long-chain fatty acids	166-188	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	47-89
26711077-1	2015	OBJECTIVE: To explore the methylation level of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) gene promoter region in mitochondria of trophoblasts incubated with long-chain fatty acids and the time-effect of methylation modification.	long-chain fatty acids	166-188	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	91-96
26711077-17	2015	CONCLUSIONS: Methylation modification effect on LCHAD gene promoter region in trophoblast cells incubated with long-chain fatty acids is more significant than with medium-chain and short-chain fatty acids and shows obvious time-effect as incubation time prolonged.	long-chain fatty acids	111-133	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	48-53
26345771-3	2015	FASN (fatty acid synthase) plays an important role in de novo lipogenesis, through catalyzing the reductive synthesis of long-chain fatty acids.	long-chain fatty acids	121-143	fatty acid synthase	Sus scrofa	6-25
26001654-8	2015	This still holds true for GPR40 and GPR120 as sensors for medium/long-chain fatty acids and GPR41 and GPR43 for microbiota-derived short-chain fatty acids.	long-chain fatty acids	65-87	free fatty acid receptor 1	Homo sapiens	26-31
26001654-8	2015	This still holds true for GPR40 and GPR120 as sensors for medium/long-chain fatty acids and GPR41 and GPR43 for microbiota-derived short-chain fatty acids.	long-chain fatty acids	65-87	free fatty acid receptor 4	Homo sapiens	36-42
25721401-2	2015	ACAD9 also retains enzyme ACAD activity for long-chain fatty acids in vitro, but the biological relevance of this function remains controversial partly because of the tissue specificity of ACAD9 expression: high in liver and neurons and minimal in skin fibroblasts.	long-chain fatty acids	44-66	acyl-CoA dehydrogenase family member 9	Homo sapiens	0-5
25053716-2	2015	We recently reported that caspase-2 was pivotal for the induction of cell death triggered by excessive intracellular accumulation of long-chain fatty acids, a response known as lipoapoptosis.	long-chain fatty acids	133-155	caspase 2	Mus musculus	26-35
25721401-2	2015	ACAD9 also retains enzyme ACAD activity for long-chain fatty acids in vitro, but the biological relevance of this function remains controversial partly because of the tissue specificity of ACAD9 expression: high in liver and neurons and minimal in skin fibroblasts.	long-chain fatty acids	44-66	acyl-CoA dehydrogenase family member 9	Homo sapiens	0-4
25946120-7	2015	At 4 days after surgery, insulin levels correlated positively with metabolites of branched chain and aromatic amino acid metabolism and negatively with triglycerides with long-chain fatty acids.	long-chain fatty acids	171-193	insulin	Homo sapiens	25-32
25583114-0	2015	Astrocytes and mitochondria from adrenoleukodystrophy protein (ABCD1)-deficient mice reveal that the adrenoleukodystrophy-associated very long-chain fatty acids target several cellular energy-dependent functions.	long-chain fatty acids	138-160	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	63-68
25583114-2	2015	ABCD1 mediates peroxisomal uptake of free very-long-chain fatty acids (VLCFA) as well as their CoA-esters.	long-chain fatty acids	47-69	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	0-5
25639618-2	2015	Liver FABP (L-FABP) is prominent among FABPs for its wide ligand repertoire, which includes long-chain fatty acids as well as bile acids (BAs).	long-chain fatty acids	92-114	fatty acid binding protein 1	Homo sapiens	12-18
25753196-9	2015	These results suggest that raffinose and melezitose monoesters with long-chain fatty acids (C16 to C18) are promising surfactants for pharmaceutical applications and could be an alternative to the use of current commercial nonionic polyoxyethylene-based surfactants in parenteral formulations.	long-chain fatty acids	68-90	Bardet-Biedl syndrome 9	Homo sapiens	99-102
25370574-1	2015	BACKGROUND: Adipocyte fatty acid-binding protein (FABP4) is a member of a highly conserved family of cytosolic proteins that bind with high affinity to hydrophobic ligands, such as saturated and unsaturated long-chain fatty acids and eicosanoids.	long-chain fatty acids	207-229	fatty acid binding protein 4	Homo sapiens	50-55
25598214-2	2015	Several studies have suggested that ACBP acts as an acyl-CoA pool former and regulates long-chain fatty acids (LCFA) metabolism in peripheral tissues.	long-chain fatty acids	87-109	diazepam binding inhibitor	Mus musculus	36-40
25598214-12	2015	Using brain slices, cortical, and hypothalamic astrocyte cultures from ACBP KO mice, we demonstrate that ACBP mainly localizes in astrocytes and regulates unsaturated but not saturated long-chain fatty acids (LCFA) metabolism.	long-chain fatty acids	185-207	diazepam binding inhibitor	Mus musculus	105-109
25141826-1	2015	Children with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHAD) have a defect in the degradation of long-chain fatty acids and are at risk of hypoketotic hypoglycemia and insufficient energy production as well as accumulation of toxic fatty acid intermediates.	long-chain fatty acids	112-134	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	69-74
25698233-7	2015	In addition, a number of PACAP-analogs were identified that had high selectivity for PAC1-R over VPAC2-R as well as PACAP-analogs that could prove more useful therapeutically because of substitutions known to extend their half-lives (substitutions at potential sites of proteolysis and attachment of long-chain fatty acids).	long-chain fatty acids	300-322	adenylate cyclase activating polypeptide 1	Homo sapiens	25-30
25790291-2	2015	GPR120 (FFA4) is a G protein-coupled receptor (GPCR) for long-chain fatty acids that functions as a regulator of physiological energy metabolism.	long-chain fatty acids	57-79	free fatty acid receptor 4	Homo sapiens	0-6
25519905-0	2015	Rom2-dependent phosphorylation of Elo2 controls the abundance of very long-chain fatty acids.	long-chain fatty acids	70-92	ELOVL fatty acid elongase 6	Homo sapiens	34-38
25729276-1	2015	"G protein-coupled receptor 40" (GPR40), a receptor for long-chain fatty acids, mediates the stimulation of glucose-induced insulin secretion.	long-chain fatty acids	56-78	free fatty acid receptor 1	Rattus norvegicus	0-31
25729276-1	2015	"G protein-coupled receptor 40" (GPR40), a receptor for long-chain fatty acids, mediates the stimulation of glucose-induced insulin secretion.	long-chain fatty acids	56-78	free fatty acid receptor 1	Rattus norvegicus	33-38
26567099-1	2014	BACKGROUND: Deficiency of very long-chain acyl-CoA dehydrogenase (VLCAD) is the most common disorder of mitochondrial beta-oxidation of long-chain fatty acids.	long-chain fatty acids	136-158	acyl-Coenzyme A dehydrogenase, very long chain	Mus musculus	66-71
25147052-1	2015	Epidermal fatty acid-binding protein (E-FABP/FABP5/DA11) binds and transport long-chain fatty acids in the cytoplasm and may play a protecting role during neuronal injury.	long-chain fatty acids	77-99	fatty acid binding protein 5	Rattus norvegicus	0-36
25147052-1	2015	Epidermal fatty acid-binding protein (E-FABP/FABP5/DA11) binds and transport long-chain fatty acids in the cytoplasm and may play a protecting role during neuronal injury.	long-chain fatty acids	77-99	fatty acid binding protein 5	Rattus norvegicus	38-44
25147052-1	2015	Epidermal fatty acid-binding protein (E-FABP/FABP5/DA11) binds and transport long-chain fatty acids in the cytoplasm and may play a protecting role during neuronal injury.	long-chain fatty acids	77-99	fatty acid binding protein 5	Rattus norvegicus	45-50
25147052-1	2015	Epidermal fatty acid-binding protein (E-FABP/FABP5/DA11) binds and transport long-chain fatty acids in the cytoplasm and may play a protecting role during neuronal injury.	long-chain fatty acids	77-99	fatty acid binding protein 5	Rattus norvegicus	51-55
25614308-1	2015	BACKGROUND: Carnitine-acylcarnitine translocase (CACT) deficiency is a rare autosomal recessive disease in the mitochondrial transport of long-chain fatty acids.	long-chain fatty acids	138-160	solute carrier family 25 member 20	Homo sapiens	12-47
25614308-1	2015	BACKGROUND: Carnitine-acylcarnitine translocase (CACT) deficiency is a rare autosomal recessive disease in the mitochondrial transport of long-chain fatty acids.	long-chain fatty acids	138-160	solute carrier family 25 member 20	Homo sapiens	49-53
25281760-1	2014	Elongation of very long chain fatty acid-like family member 6 (ELOVL6) is a fatty acyl elongase that performs the initial and rate-limiting condensing reaction required for microsomal elongation of long-chain fatty acids.	long-chain fatty acids	198-220	ELOVL family member 6, elongation of long chain fatty acids (yeast)	Mus musculus	63-69
25112963-1	2015	G-protein-coupled receptor 120 (GPR120) has been known to be a receptor of long-chain fatty acids.	long-chain fatty acids	75-97	free fatty acid receptor 4	Mus musculus	0-30
25112963-1	2015	G-protein-coupled receptor 120 (GPR120) has been known to be a receptor of long-chain fatty acids.	long-chain fatty acids	75-97	free fatty acid receptor 4	Mus musculus	32-38
24947174-2	2014	As one of the target genes of SREBP1 and PPARgamma, fatty acid-binding protein 3(FABP3) is the main protein allowing for rapid diffusion and selective targeting of long-chain fatty acids toward specific organelles for metabolism.	long-chain fatty acids	164-186	sterol regulatory element binding transcription factor 1	Bos taurus	30-36
25414667-4	2014	GPR40/FFAR1 and GPR120/FFAR4 are activated by medium- and/or long-chain fatty acids, whereas GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain fatty acids.	long-chain fatty acids	61-83	free fatty acid receptor 1	Homo sapiens	0-5
25414667-4	2014	GPR40/FFAR1 and GPR120/FFAR4 are activated by medium- and/or long-chain fatty acids, whereas GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain fatty acids.	long-chain fatty acids	61-83	free fatty acid receptor 1	Homo sapiens	6-11
25414667-4	2014	GPR40/FFAR1 and GPR120/FFAR4 are activated by medium- and/or long-chain fatty acids, whereas GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain fatty acids.	long-chain fatty acids	61-83	free fatty acid receptor 4	Homo sapiens	16-22
25414667-4	2014	GPR40/FFAR1 and GPR120/FFAR4 are activated by medium- and/or long-chain fatty acids, whereas GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain fatty acids.	long-chain fatty acids	61-83	free fatty acid receptor 4	Homo sapiens	23-28
24947174-2	2014	As one of the target genes of SREBP1 and PPARgamma, fatty acid-binding protein 3(FABP3) is the main protein allowing for rapid diffusion and selective targeting of long-chain fatty acids toward specific organelles for metabolism.	long-chain fatty acids	164-186	peroxisome proliferator activated receptor gamma	Bos taurus	41-50
24947174-2	2014	As one of the target genes of SREBP1 and PPARgamma, fatty acid-binding protein 3(FABP3) is the main protein allowing for rapid diffusion and selective targeting of long-chain fatty acids toward specific organelles for metabolism.	long-chain fatty acids	164-186	fatty acid binding protein 3	Bos taurus	52-80
24947174-2	2014	As one of the target genes of SREBP1 and PPARgamma, fatty acid-binding protein 3(FABP3) is the main protein allowing for rapid diffusion and selective targeting of long-chain fatty acids toward specific organelles for metabolism.	long-chain fatty acids	164-186	fatty acid binding protein 3	Bos taurus	81-86
24879443-2	2014	Fatty acid-binding proteins (FABPs) bind and transport hydrophobic long-chain fatty acids intracellularly, and epidermal-type FABP (E-FABP) has an affinity for n-3 fatty acids.	long-chain fatty acids	67-89	fatty acid binding protein 5, epidermal	Mus musculus	132-138
25309513-3	2014	Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be highly expressed in pancreatic beta cells and involved in the regulation of insulin secretion.	long-chain fatty acids	64-86	free fatty acid receptor 1	Homo sapiens	10-39
25309513-3	2014	Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be highly expressed in pancreatic beta cells and involved in the regulation of insulin secretion.	long-chain fatty acids	64-86	free fatty acid receptor 1	Homo sapiens	41-46
25255441-2	2014	ABCD1 transports CoA-esters of very long-chain fatty acids (VLCFA) into peroxisomes for degradation by beta-oxidation; thus, ABCD1 deficiency results in VLCFA accumulation.	long-chain fatty acids	36-58	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	0-5
24919687-3	2014	In most animals, the elongation of very long-chain fatty acids (ELOVL) enzyme ELOVL2 is essential for conversion of dietary ALA to DHA because only ELOVL2 and not ELOVL5 can elongate docosapentaenoic acid (DPA; 22:5n-3) to 24:5n-3, the precursor of DHA.	long-chain fatty acids	40-62	ELOVL fatty acid elongase 2	Meleagris gallopavo	78-84
25022676-7	2014	Addition of the PPARG ligand rosiglitazone (ROSI) to GMEC overexpressing both isoforms upregulated the expression of LPL and CD36, which help control uptake of long-chain fatty acids into mammary cells.	long-chain fatty acids	160-182	peroxisome proliferator-activated receptor gamma	Capra hircus	16-21
25049234-5	2014	TER is known to be involved in the production of very long-chain fatty acids (VLCFAs).	long-chain fatty acids	54-76	trans-2,3-enoyl-CoA reductase	Homo sapiens	0-3
24919687-3	2014	In most animals, the elongation of very long-chain fatty acids (ELOVL) enzyme ELOVL2 is essential for conversion of dietary ALA to DHA because only ELOVL2 and not ELOVL5 can elongate docosapentaenoic acid (DPA; 22:5n-3) to 24:5n-3, the precursor of DHA.	long-chain fatty acids	40-62	ELOVL fatty acid elongase 2	Meleagris gallopavo	148-154
24571165-1	2014	gamma-Butyrobetaine hydroxylase (BBOX) catalyzes the conversion of gamma butyrobetaine (GBB) to l-carnitine, which is involved in the generation of metabolic energy from long-chain fatty acids.	long-chain fatty acids	170-192	gamma-butyrobetaine hydroxylase 1	Homo sapiens	0-31
24828044-8	2014	Notably, Mfsd2a transports common plasma LPCs carrying long-chain fatty acids such LPC oleate and LPC palmitate, but not LPCs with less than a 14-carbon acyl chain.	long-chain fatty acids	55-77	major facilitator superfamily domain containing 2A	Mus musculus	9-15
24665124-6	2014	Furthermore, myeloid cell expression of the enzyme acyl-CoA synthetase 1 (ACSL1), which converts long-chain fatty acids into their acyl-CoA derivatives, has emerged as causal to diabetes mellitus-induced lesion initiation.	long-chain fatty acids	97-119	acyl-CoA synthetase long-chain family member 1	Mus musculus	74-79
24489111-2	2014	Elongation of very long-chain fatty acids (ELOVLs) in mammals is catalyzed by the ELOVL enzymes to which the PUFA elongase ELOVL2 belongs.	long-chain fatty acids	19-41	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	Mus musculus	123-129
24938128-1	2014	ELOVL family member 6, elongation of very long-chain fatty acids (Elovl6) is a microsomal enzyme that regulates the elongation of C12-16 saturated and monounsaturated fatty acids and is related to the development of obesity-induced insulin resistance via the modification of the fatty acid composition.	long-chain fatty acids	42-64	ELOVL family member 6, elongation of long chain fatty acids (yeast)	Mus musculus	66-72
24363066-2	2014	The ABCD1 protein transports CoA-activated very long-chain fatty acids (VLCFAs) into peroxisomes for degradation via beta-oxidation.	long-chain fatty acids	48-70	ATP binding cassette subfamily D member 1	Homo sapiens	4-9
24357536-2	2014	Although long-chain fatty acids (FAs, >= C12) are well known to stimulate CCK secretion, the CCK-releasing activities of other aliphatic compounds, such as aldehydes (Alds) or alcohols (Alcs), have not been studied.	long-chain fatty acids	9-31	cholecystokinin	Homo sapiens	77-80
24571165-1	2014	gamma-Butyrobetaine hydroxylase (BBOX) catalyzes the conversion of gamma butyrobetaine (GBB) to l-carnitine, which is involved in the generation of metabolic energy from long-chain fatty acids.	long-chain fatty acids	170-192	gamma-butyrobetaine hydroxylase 1	Homo sapiens	33-37
24553921-2	2014	Mutations in acyl-CoA synthetase long-chain family member 4 (ACSL4), which converts long-chain fatty acids to acyl-CoAs, result in nonsyndromic X-linked mental retardation.	long-chain fatty acids	84-106	acyl-CoA synthetase long chain family member 4	Homo sapiens	61-66
24316281-3	2014	ABCD1 transports CoA-activated very long-chain fatty acids from the cytosol into the peroxisome for degradation.	long-chain fatty acids	36-58	ATP binding cassette subfamily D member 1	Homo sapiens	0-5
24008422-0	2014	Interferon-gamma decreases ceramides with long-chain fatty acids: possible involvement in atopic dermatitis and psoriasis.	long-chain fatty acids	42-64	interferon gamma	Homo sapiens	0-16
24008422-6	2014	Using cultured human keratinocytes and epidermal sheets, we found that only IFN-gamma among various cytokines decreased the mRNA expression of elongase of long-chain fatty acids (ELOVL) and ceramide synthase (CerS), enzymes involved in FA chain elongation.	long-chain fatty acids	155-177	interferon gamma	Homo sapiens	76-85
24076127-3	2014	The disease is caused by loss of function of the ABCD1 gene, a peroxisomal ATP-binding cassette transporter, resulting in the accumulation of VLCFA (very long-chain fatty acids) in organs and plasma.	long-chain fatty acids	154-176	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	49-54
24480483-2	2014	The disease is caused by mutations in the ABCD1 gene that encodes the peroxisomal transporter of very long-chain fatty acids.	long-chain fatty acids	102-124	ATP binding cassette subfamily D member 1	Homo sapiens	42-47
24480483-3	2014	A defect in the ABCD1 protein results in elevated levels of very long-chain fatty acids in plasma and tissues.	long-chain fatty acids	65-87	ATP binding cassette subfamily D member 1	Homo sapiens	16-21
24306512-1	2014	Abnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel disease (IBD).	long-chain fatty acids	121-143	fatty acid synthase	Mus musculus	60-79
23914904-2	2014	Carnitine palmitoyltransferase-1 (CPT1), an enzyme responsible for the transport of long-chain fatty acids for beta-oxidation, is closely related to fat deposition.	long-chain fatty acids	84-106	carnitine palmitoyltransferase 1B	Sus scrofa	0-32
23914904-2	2014	Carnitine palmitoyltransferase-1 (CPT1), an enzyme responsible for the transport of long-chain fatty acids for beta-oxidation, is closely related to fat deposition.	long-chain fatty acids	84-106	carnitine palmitoyltransferase 1B	Sus scrofa	34-38
24306512-1	2014	Abnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel disease (IBD).	long-chain fatty acids	121-143	fatty acid synthase	Mus musculus	81-85
24584021-7	2014	Among these receptors, G protein-coupled receptor 40 (GPR40) has been reported to be activated by long-chain fatty acids such as DHA, eicosapentaenoic acid (EPA) and arachidonic acid.	long-chain fatty acids	98-120	free fatty acid receptor 1	Homo sapiens	23-52
24222669-12	2014	These results suggest that the decrease of ghrelin secretion after feeding is induced partially by long-chain fatty acids that act directly on gastric GPR120-expressing ghrelin cells.	long-chain fatty acids	99-121	ghrelin	Mus musculus	43-50
24222669-12	2014	These results suggest that the decrease of ghrelin secretion after feeding is induced partially by long-chain fatty acids that act directly on gastric GPR120-expressing ghrelin cells.	long-chain fatty acids	99-121	free fatty acid receptor 4	Mus musculus	151-157
24222669-12	2014	These results suggest that the decrease of ghrelin secretion after feeding is induced partially by long-chain fatty acids that act directly on gastric GPR120-expressing ghrelin cells.	long-chain fatty acids	99-121	ghrelin	Mus musculus	169-176
25743342-1	2014	We recently reported that G-protein-coupled receptor 120 (GPR120) is expressed on taste buds, and that rodents showed preference for long-chain fatty acids (LCFA) at a low concentration.	long-chain fatty acids	133-155	free fatty acid receptor 4	Mus musculus	26-56
25743342-1	2014	We recently reported that G-protein-coupled receptor 120 (GPR120) is expressed on taste buds, and that rodents showed preference for long-chain fatty acids (LCFA) at a low concentration.	long-chain fatty acids	133-155	free fatty acid receptor 4	Mus musculus	58-64
25269899-9	2014	RESULTS: Cells treated with long-chain fatty acids showed significant increased lipid droplets deposition, severe mitochondrial damage, decreased CPT2 and LCHAD protein expression (P < 0.05) but no significant difference in CPT1 protein expression (P > 0.05).	long-chain fatty acids	28-50	carnitine palmitoyltransferase 2	Homo sapiens	146-150
25269899-9	2014	RESULTS: Cells treated with long-chain fatty acids showed significant increased lipid droplets deposition, severe mitochondrial damage, decreased CPT2 and LCHAD protein expression (P < 0.05) but no significant difference in CPT1 protein expression (P > 0.05).	long-chain fatty acids	28-50	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	155-160
24584021-7	2014	Among these receptors, G protein-coupled receptor 40 (GPR40) has been reported to be activated by long-chain fatty acids such as DHA, eicosapentaenoic acid (EPA) and arachidonic acid.	long-chain fatty acids	98-120	free fatty acid receptor 1	Homo sapiens	54-59
24204965-6	2013	However, HNE strongly potentiated the membrane conductance increase (Gm) mediated by different long-chain fatty acids in UCP-containing and in UCP-free membranes and this suggest the involvement of both lipid-mediated and protein-mediated mechanisms with FA playing the central role.	long-chain fatty acids	95-117	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	121-124
24349089-1	2013	GPR40 has been reported to be activated by long-chain fatty acids, such as docosahexaenoic acid (DHA).	long-chain fatty acids	43-65	free fatty acid receptor 1	Mus musculus	0-5
24088670-1	2013	Carnitine-acylcarnitine translocase (CACT) and carnitine palmitoyltransferase II (CPT2) are key enzymes for transporting long-chain fatty acids into mitochondria.	long-chain fatty acids	121-143	solute carrier family 25 member 20	Homo sapiens	0-35
24088670-1	2013	Carnitine-acylcarnitine translocase (CACT) and carnitine palmitoyltransferase II (CPT2) are key enzymes for transporting long-chain fatty acids into mitochondria.	long-chain fatty acids	121-143	solute carrier family 25 member 20	Homo sapiens	37-41
24088670-1	2013	Carnitine-acylcarnitine translocase (CACT) and carnitine palmitoyltransferase II (CPT2) are key enzymes for transporting long-chain fatty acids into mitochondria.	long-chain fatty acids	121-143	carnitine palmitoyltransferase 2	Homo sapiens	47-80
24088670-1	2013	Carnitine-acylcarnitine translocase (CACT) and carnitine palmitoyltransferase II (CPT2) are key enzymes for transporting long-chain fatty acids into mitochondria.	long-chain fatty acids	121-143	carnitine palmitoyltransferase 2	Homo sapiens	82-86
24243599-3	2013	In this paper, we have investigated the ability of covalently linked long-chain fatty acids in modulating the self-assembly of an aromatic amino acid-rich highly amyloidogenic sequence derived from the amino acid region 59-71 of human beta2-microglobulin by thioflavin T (ThT) fluorescence microscopy, circular dichroism, and fluorescence spectroscopy.	long-chain fatty acids	69-91	beta-2-microglobulin	Homo sapiens	235-254
25014867-1	2013	In very long-chain acylCoA dehydrogenase deficiency (VLCAD), the activity of this enzyme is either reduced or absent with the inability to use long-chain fatty acids as energy substrates.	long-chain fatty acids	143-165	acyl-CoA dehydrogenase very long chain	Homo sapiens	53-58
24052263-0	2013	Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.	long-chain fatty acids	47-69	sirtuin 6	Homo sapiens	38-43
23643928-1	2013	BACKGROUND: Serum albumin is a major transport protein in mammals and is known to have at least seven binding sites for long-chain fatty acids (FAs).	long-chain fatty acids	120-142	albumin	Homo sapiens	12-25
24118240-4	2013	Among the many metabolite changes detected, the most characteristic metabolites uniquely indicated carnitine palmitoyltransferase-1 (CPT1), the critical enzyme for mitochondrial beta-oxidation of long-chain fatty acids, to be a target for oxidative inactivation.	long-chain fatty acids	196-218	carnitine palmitoyltransferase 1A	Homo sapiens	99-131
24118240-4	2013	Among the many metabolite changes detected, the most characteristic metabolites uniquely indicated carnitine palmitoyltransferase-1 (CPT1), the critical enzyme for mitochondrial beta-oxidation of long-chain fatty acids, to be a target for oxidative inactivation.	long-chain fatty acids	196-218	carnitine palmitoyltransferase 1A	Homo sapiens	133-137
24241823-2	2013	Due to its involvement in the metabolism of long-chain fatty acids and cholesterol uptake, it has been the focus of intense research in mammals and insects; much less characterized are SCP2 from other eukaryotic cells and microorganisms.	long-chain fatty acids	44-66	sterol carrier protein 2	Homo sapiens	185-189
23903678-1	2013	Recent animal studies have indicated that overexpression of the elongation of long-chain fatty acids family member 6 (Elovl6) gene can cause insulin resistance and beta-cell dysfunction.	long-chain fatty acids	78-100	ELOVL fatty acid elongase 6	Homo sapiens	118-124
23794606-1	2013	X-linked adrenoleukodystrophy is a neurometabolic disorder caused by inactivation of the peroxisomal ABCD1 transporter of very long-chain fatty acids.	long-chain fatty acids	127-149	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	101-106
24005625-2	2013	Insulin release is chiefly stimulated by glucose, but also modulated by other nutrients, including long-chain fatty acids which potentiate glucose-induced insulin secretion.	long-chain fatty acids	99-121	insulin	Homo sapiens	0-7
23933272-3	2013	In this paper we report an AML case showing a novel t(4;16)(q25;q23.1) rearrangement causing the activation of epidermal growth factor (EGF) and elongation of long-chain fatty acids family member 6 (ELOVL6) genes, rather than the generation of a novel fusion gene.	long-chain fatty acids	159-181	ELOVL fatty acid elongase 6	Homo sapiens	199-205
23938082-2	2013	Deficiencies in LC-PUFAs and VLC-PUFAs, as well as mutations in the enzyme responsible for elongation of very long-chain fatty acids (ELOVL4), have been associated with macular dystrophies and degenerations.	long-chain fatty acids	110-132	ELOVL fatty acid elongase 4	Homo sapiens	134-140
23766131-6	2013	However, acute treatment of PDE3B KO mice with the beta3-adrenergic agonist, CL316243, markedly increased the expression of cyclooxygenase-2, which catalyzes prostaglandin synthesis and is thought to be important in the formation of BAT in WAT and the elongation of very long-chain fatty acids 3, which is linked to BAT recruitment upon cold exposure, causing a clear shift toward fat burning and the induction of BAT in KO EWAT.	long-chain fatty acids	271-293	phosphodiesterase 3B, cGMP-inhibited	Mus musculus	28-33
23766131-6	2013	However, acute treatment of PDE3B KO mice with the beta3-adrenergic agonist, CL316243, markedly increased the expression of cyclooxygenase-2, which catalyzes prostaglandin synthesis and is thought to be important in the formation of BAT in WAT and the elongation of very long-chain fatty acids 3, which is linked to BAT recruitment upon cold exposure, causing a clear shift toward fat burning and the induction of BAT in KO EWAT.	long-chain fatty acids	271-293	prostaglandin-endoperoxide synthase 2	Mus musculus	124-140
23768953-1	2013	BACKGROUND: X-linked adrenoleukodystrophy (X-ALD) is a genetic disorder of X-linked inheritance caused by a mutation in the ABCD1 gene which determines an accumulation of long-chain fatty acids in plasma and tissues.	long-chain fatty acids	171-193	ATP binding cassette subfamily D member 1	Homo sapiens	124-129
23903678-1	2013	Recent animal studies have indicated that overexpression of the elongation of long-chain fatty acids family member 6 (Elovl6) gene can cause insulin resistance and beta-cell dysfunction.	long-chain fatty acids	78-100	insulin	Homo sapiens	141-148
23492556-2	2013	Loss of function of the peroxisomal ABCD1 fatty-acid transporter, resulting in the accumulation of very long-chain fatty acids in organs and plasma, is the genetic cause.	long-chain fatty acids	104-126	ATP binding cassette subfamily D member 1	Homo sapiens	36-41
23602251-6	2013	Overexpression of wild-type PGC-1alpha, but not mutant PGC-1alpha, also caused a significant increase in hepatocyte expression of carnitine palmitoyl transferase 1a, a rate-determining enzyme that transfers long-chain fatty acids into mitochondria for oxidation.	long-chain fatty acids	207-229	PPARG coactivator 1 alpha	Rattus norvegicus	28-38
23403053-2	2013	FFA1 (GPR40) and GPR120 are G-protein-coupled receptors activated by long-chain fatty acids.	long-chain fatty acids	69-91	free fatty acid receptor 1	Mus musculus	6-11
23403053-2	2013	FFA1 (GPR40) and GPR120 are G-protein-coupled receptors activated by long-chain fatty acids.	long-chain fatty acids	69-91	free fatty acid receptor 4	Mus musculus	17-23
23415518-1	2013	Milk fat synthesis might be promoted by the dietary addition of long-chain fatty acids (LCFA) or short- and medium-chain fatty acids (SMCFA).	long-chain fatty acids	64-86	LCFA	Bos taurus	88-92
22932756-5	2012	The lpcat1/lpcat2 mutant showed increased contents of very-long-chain fatty acids and decreased PUFA in TAG and the accumulation of small amounts of lysophosphatidylcholine in developing seeds revealed by [14C]acetate-labeling experiments.	long-chain fatty acids	59-81	MBOAT (membrane bound O-acyl transferase) family protein	Arabidopsis thaliana	4-10
23555103-1	2013	The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population.	long-chain fatty acids	175-197	fatty acid desaturase 1	Homo sapiens	86-109
23555103-1	2013	The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population.	long-chain fatty acids	175-197	fatty acid desaturase 1	Homo sapiens	111-116
23555103-1	2013	The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population.	long-chain fatty acids	175-197	fatty acid desaturase 2	Homo sapiens	119-142
23555103-1	2013	The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population.	long-chain fatty acids	175-197	fatty acid desaturase 2	Homo sapiens	144-149
23555103-1	2013	The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population.	long-chain fatty acids	175-197	ELOVL fatty acid elongase 2	Homo sapiens	206-212
24113622-2	2013	The elongation of long-chain fatty acids family member 6 (Elovl6) is a rate-limiting enzyme catalysing the elongation of saturated and monounsaturated fatty acids.	long-chain fatty acids	18-40	ELOVL family member 6, elongation of long chain fatty acids (yeast)	Mus musculus	58-64
23737762-5	2013	As in monogastrics, PPAR isotypes in ruminants are activated by long-chain fatty acids, therefore, making them ideal candidates for fine-tuning metabolism in this species via nutrients.	long-chain fatty acids	64-86	peroxisome proliferator activated receptor alpha	Mus musculus	20-24
23316967-6	2013	Substantial upregulation of adipose and liver carnitine palmitoyltransferase (Cpt) 1, the rate-limiting enzyme in the transport of long-chain fatty acids into mitochondria, occurred by 2 months.	long-chain fatty acids	131-153	carnitine palmitoyltransferase 1b, muscle	Mus musculus	46-84
23302080-1	2013	Fatty acid-binding protein (FABP) has high affinity for long-chain fatty acids and appears to participate in the metabolism and intracellular transport of lipids.	long-chain fatty acids	56-78	fatty acid-binding protein, intestinal	Bos taurus	28-32
22952014-4	2013	Since carnitine is essential for beta-oxidation of long-chain fatty acids to produce ATP, OCTN2 gene mutation causes a range of symptoms, including cardiomyopathy, skeletal muscle weakness, fatty liver and male infertility.	long-chain fatty acids	51-73	solute carrier family 22 (organic cation transporter), member 5	Mus musculus	90-95
23349733-2	2013	A genome-wide association study (GWAS) identified a novel narcolepsy-related single nucleotide polymorphism (SNP), which is located adjacent to the carnitine palmitoyltransferase 1B (CPT1B) gene encoding an enzyme involved in beta-oxidation of long-chain fatty acids.	long-chain fatty acids	244-266	carnitine palmitoyltransferase 1B	Homo sapiens	148-181
23349733-2	2013	A genome-wide association study (GWAS) identified a novel narcolepsy-related single nucleotide polymorphism (SNP), which is located adjacent to the carnitine palmitoyltransferase 1B (CPT1B) gene encoding an enzyme involved in beta-oxidation of long-chain fatty acids.	long-chain fatty acids	244-266	carnitine palmitoyltransferase 1B	Homo sapiens	183-188
22447153-2	2012	ALDP deficiency results in impaired peroxisomal beta-oxidation and the subsequent accumulation of very long-chain fatty acids (VLCFA; > C22:0) in plasma and tissues.	long-chain fatty acids	103-125	ATP binding cassette subfamily D member 1	Homo sapiens	0-4
22932756-5	2012	The lpcat1/lpcat2 mutant showed increased contents of very-long-chain fatty acids and decreased PUFA in TAG and the accumulation of small amounts of lysophosphatidylcholine in developing seeds revealed by [14C]acetate-labeling experiments.	long-chain fatty acids	59-81	MBOAT (membrane bound O-acyl transferase) family protein	Arabidopsis thaliana	11-17
22820510-1	2012	AIMS/HYPOTHESIS: Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy.	long-chain fatty acids	73-95	free fatty acid receptor 1	Mus musculus	35-69
23063128-2	2012	Upon activation by long-chain fatty acids (LCFAs), UCP1 increases the conductance of the inner mitochondrial membrane (IMM) to make BAT mitochondria generate heat rather than ATP.	long-chain fatty acids	19-41	uncoupling protein 1	Homo sapiens	51-55
22859366-1	2012	The liver expresses high levels of two proteins with high affinity for long-chain fatty acids (LCFAs): liver fatty acid binding protein (L-FABP) and sterol carrier protein-2 (SCP-2).	long-chain fatty acids	71-93	fatty acid binding protein 1, liver	Mus musculus	103-135
22859366-1	2012	The liver expresses high levels of two proteins with high affinity for long-chain fatty acids (LCFAs): liver fatty acid binding protein (L-FABP) and sterol carrier protein-2 (SCP-2).	long-chain fatty acids	71-93	fatty acid binding protein 1, liver	Mus musculus	137-143
22859366-1	2012	The liver expresses high levels of two proteins with high affinity for long-chain fatty acids (LCFAs): liver fatty acid binding protein (L-FABP) and sterol carrier protein-2 (SCP-2).	long-chain fatty acids	71-93	sterol carrier protein 2, liver	Mus musculus	149-173
22859366-1	2012	The liver expresses high levels of two proteins with high affinity for long-chain fatty acids (LCFAs): liver fatty acid binding protein (L-FABP) and sterol carrier protein-2 (SCP-2).	long-chain fatty acids	71-93	sterol carrier protein 2, liver	Mus musculus	175-180
22483867-5	2012	ALDP deficiency impairs the peroxisomal beta-oxidation of very long-chain fatty acids (VLCFA) and facilitates their further chain elongation by ELOVL1 resulting in accumulation of VLCFA in plasma and tissues.	long-chain fatty acids	63-85	ATP binding cassette subfamily D member 1	Homo sapiens	0-4
22757966-5	2012	Various long-chain fatty acids differentially stimulated release of glucagon-like peptide 1 (GLP-1) (up to 500%) and glucagon-like peptide 2 (GLP-2) (up to 200%) from ileal tissue disks, but effects on peptide YY (PYY) did not reach significance.	long-chain fatty acids	8-30	glucagon	Homo sapiens	68-91
22757966-5	2012	Various long-chain fatty acids differentially stimulated release of glucagon-like peptide 1 (GLP-1) (up to 500%) and glucagon-like peptide 2 (GLP-2) (up to 200%) from ileal tissue disks, but effects on peptide YY (PYY) did not reach significance.	long-chain fatty acids	8-30	glucagon like peptide 1 receptor	Homo sapiens	93-98
22757966-5	2012	Various long-chain fatty acids differentially stimulated release of glucagon-like peptide 1 (GLP-1) (up to 500%) and glucagon-like peptide 2 (GLP-2) (up to 200%) from ileal tissue disks, but effects on peptide YY (PYY) did not reach significance.	long-chain fatty acids	8-30	glucagon	Homo sapiens	117-140
22757966-5	2012	Various long-chain fatty acids differentially stimulated release of glucagon-like peptide 1 (GLP-1) (up to 500%) and glucagon-like peptide 2 (GLP-2) (up to 200%) from ileal tissue disks, but effects on peptide YY (PYY) did not reach significance.	long-chain fatty acids	8-30	glucagon	Homo sapiens	142-147
22757966-5	2012	Various long-chain fatty acids differentially stimulated release of glucagon-like peptide 1 (GLP-1) (up to 500%) and glucagon-like peptide 2 (GLP-2) (up to 200%) from ileal tissue disks, but effects on peptide YY (PYY) did not reach significance.	long-chain fatty acids	8-30	peptide YY	Homo sapiens	202-212
22757966-5	2012	Various long-chain fatty acids differentially stimulated release of glucagon-like peptide 1 (GLP-1) (up to 500%) and glucagon-like peptide 2 (GLP-2) (up to 200%) from ileal tissue disks, but effects on peptide YY (PYY) did not reach significance.	long-chain fatty acids	8-30	peptide YY	Homo sapiens	214-217
22718502-4	2012	One of two isozymes of this enzyme, acetyl-CoA carboxylase-alpha (ACACA), catalyses the first committed step of fatty acid synthesis in mammalian cytosol, leading to the biosynthesis of long-chain fatty acids.	long-chain fatty acids	186-208	acetyl-CoA carboxylase alpha	Homo sapiens	36-64
22718502-4	2012	One of two isozymes of this enzyme, acetyl-CoA carboxylase-alpha (ACACA), catalyses the first committed step of fatty acid synthesis in mammalian cytosol, leading to the biosynthesis of long-chain fatty acids.	long-chain fatty acids	186-208	acetyl-CoA carboxylase alpha	Homo sapiens	66-71
22313587-1	2012	Long-chain fatty acids have been shown to suppress appetite and reduce energy intake (EI) by stimulating the release of gastrointestinal hormones such as cholecystokinin (CCK).	long-chain fatty acids	0-22	cholecystokinin	Homo sapiens	154-169
22889154-2	2012	The disease is caused by mutations in the ABCD1 gene that encodes the peroxisomal membrane protein ALDP which is involved in the transmembrane transport of very long-chain fatty acids (VLCFA; >= C22).	long-chain fatty acids	161-183	ATP binding cassette subfamily D member 1	Homo sapiens	42-47
22889154-2	2012	The disease is caused by mutations in the ABCD1 gene that encodes the peroxisomal membrane protein ALDP which is involved in the transmembrane transport of very long-chain fatty acids (VLCFA; >= C22).	long-chain fatty acids	161-183	ATP binding cassette subfamily D member 1	Homo sapiens	99-103
22313587-1	2012	Long-chain fatty acids have been shown to suppress appetite and reduce energy intake (EI) by stimulating the release of gastrointestinal hormones such as cholecystokinin (CCK).	long-chain fatty acids	0-22	cholecystokinin	Homo sapiens	171-174
22521588-7	2012	As a myelin-enriched putative sugar transporter, SLC45A3 enhances intracellular glucose levels and the synthesis of long-chain fatty acids.	long-chain fatty acids	116-138	solute carrier family 45 member 3	Homo sapiens	49-56
22330023-2	2012	A variety of molecular components can activate TLR2 and TLR4, among others, long-chain fatty acids.	long-chain fatty acids	76-98	toll-like receptor 2	Mus musculus	47-51
22330023-2	2012	A variety of molecular components can activate TLR2 and TLR4, among others, long-chain fatty acids.	long-chain fatty acids	76-98	toll-like receptor 4	Mus musculus	56-60
23012892-5	2012	Among these receptors, GPR40 has been reported to be activated by long-chain fatty acids such as DHA, eicosapentaenoic acid (EPA) and arachidonic acid.	long-chain fatty acids	66-88	free fatty acid receptor 1	Homo sapiens	23-28
22436697-1	2012	Here, we show that Elovl3 (elongation of very long-chain fatty acids 3) was involved in the regulation of the progression of adipogenesis through activation of peroxisome proliferator-activated receptor (PPAR)gamma in mouse adipocytic 3T3-L1 cells.	long-chain fatty acids	46-68	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	19-25
22436697-1	2012	Here, we show that Elovl3 (elongation of very long-chain fatty acids 3) was involved in the regulation of the progression of adipogenesis through activation of peroxisome proliferator-activated receptor (PPAR)gamma in mouse adipocytic 3T3-L1 cells.	long-chain fatty acids	46-68	peroxisome proliferator activated receptor gamma	Mus musculus	204-214
22436697-7	2012	In a mammalian two-hybrid assay, C18:1 and C20:1 very long-chain fatty acids (VLCFAs), which are the products of Elovl3 and activated PPARgamma function.	long-chain fatty acids	54-76	ELOVL fatty acid elongase 3	Homo sapiens	113-119
22436697-7	2012	In a mammalian two-hybrid assay, C18:1 and C20:1 very long-chain fatty acids (VLCFAs), which are the products of Elovl3 and activated PPARgamma function.	long-chain fatty acids	54-76	peroxisome proliferator activated receptor gamma	Homo sapiens	134-143
22866302-1	2012	Albumin is a carrier of nonesterified long-chain fatty acids and many other ligands.	long-chain fatty acids	38-60	albumin	Homo sapiens	0-7
22988513-4	2012	Feeding a diet supplemented with 0.3% trans-10, cis-12-CLA (wt/wt basis) for 6 weeks increased liver mass and concentration of long-chain fatty acids (LCFAs) in liver, while adipose tissue mass decreased markedly.	long-chain fatty acids	127-149	clasper	Mus musculus	55-58
22056209-8	2012	Calcium salts of long-chain fatty acids increased plasma ghrelin concentration, and the ghrelin concentration with CLFAs plus RPM was the highest among the treatments.	long-chain fatty acids	17-39	ghrelin and obestatin prepropeptide	Bos taurus	57-64
22293348-5	2012	mRNA levels of SCD1 and elongation of very long-chain fatty acids (Elovl6), but not Elovl5, in the liver of SHR/NDcp were remarkably higher than those of the other four groups of rats.	long-chain fatty acids	43-65	ELOVL fatty acid elongase 6	Rattus norvegicus	67-73
22519963-1	2012	GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases.	long-chain fatty acids	36-58	free fatty acid receptor 4	Homo sapiens	0-6
22519963-1	2012	GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases.	long-chain fatty acids	36-58	glucagon like peptide 1 receptor	Homo sapiens	79-84
22519963-1	2012	GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases.	long-chain fatty acids	36-58	insulin	Homo sapiens	96-103
22386849-1	2012	The long-chain acyl-CoA dehydrogenase (LCAD) (Acadl=gene; LCAD=protein) deficient mouse model has been important in evaluating the role of mitochondrial fatty acid oxidation of long-chain fatty acids in metabolic disorders.	long-chain fatty acids	177-199	acyl-Coenzyme A dehydrogenase, long-chain	Mus musculus	4-37
22386849-1	2012	The long-chain acyl-CoA dehydrogenase (LCAD) (Acadl=gene; LCAD=protein) deficient mouse model has been important in evaluating the role of mitochondrial fatty acid oxidation of long-chain fatty acids in metabolic disorders.	long-chain fatty acids	177-199	acyl-Coenzyme A dehydrogenase, long-chain	Mus musculus	39-43
22386849-1	2012	The long-chain acyl-CoA dehydrogenase (LCAD) (Acadl=gene; LCAD=protein) deficient mouse model has been important in evaluating the role of mitochondrial fatty acid oxidation of long-chain fatty acids in metabolic disorders.	long-chain fatty acids	177-199	acyl-Coenzyme A dehydrogenase, long-chain	Mus musculus	46-51
22386849-1	2012	The long-chain acyl-CoA dehydrogenase (LCAD) (Acadl=gene; LCAD=protein) deficient mouse model has been important in evaluating the role of mitochondrial fatty acid oxidation of long-chain fatty acids in metabolic disorders.	long-chain fatty acids	177-199	acyl-Coenzyme A dehydrogenase, long-chain	Mus musculus	58-62
22095690-3	2012	Loss of function of the ABCD1 peroxisomal fatty acid transporter and subsequent accumulation of very-long-chain fatty acids (VLCFAs) are the common culprits to all forms of X-ALD, an aberrant microglial activation accounts for the cerebral forms, whereas inflammation allegedly plays no role in AMN.	long-chain fatty acids	101-123	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	24-29
22300073-7	2012	FFA1, previously GPR40, is activated by long-chain fatty acids with GPR120 activated by medium- and long-chain fatty acids.	long-chain fatty acids	40-62	free fatty acid receptor 1	Homo sapiens	17-22
22300073-7	2012	FFA1, previously GPR40, is activated by long-chain fatty acids with GPR120 activated by medium- and long-chain fatty acids.	long-chain fatty acids	40-62	free fatty acid receptor 4	Homo sapiens	68-74
22075538-2	2012	A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids.	long-chain fatty acids	88-110	CD36 molecule	Homo sapiens	30-34
22348016-3	2012	Fatty acid synthase (FAS) plays a central role in lipid metabolism as a key enzyme in the formation of long-chain fatty acids.	long-chain fatty acids	103-125	fatty acid synthase	Mus musculus	0-19
22485149-1	2012	Fatty acid synthase (FASN), a key player in the de novo synthetic pathway of long-chain fatty acids, has been shown to contribute to the tumorigenesis in various types of solid tumors.	long-chain fatty acids	77-99	fatty acid synthase	Homo sapiens	0-19
22485149-1	2012	Fatty acid synthase (FASN), a key player in the de novo synthetic pathway of long-chain fatty acids, has been shown to contribute to the tumorigenesis in various types of solid tumors.	long-chain fatty acids	77-99	fatty acid synthase	Homo sapiens	21-25
22348016-3	2012	Fatty acid synthase (FAS) plays a central role in lipid metabolism as a key enzyme in the formation of long-chain fatty acids.	long-chain fatty acids	103-125	fatty acid synthase	Mus musculus	21-24
22004349-9	2011	Ras increases the abundance and alters the labeling patterns of saturated and monounsaturated very-long-chain fatty acids, with the observed pattern consistent with Ras leading to enhanced activity of ELOVL4 or an enzyme with similar catalytic activity.	long-chain fatty acids	99-121	ELOVL fatty acid elongase 4	Homo sapiens	201-207
21453200-3	2011	The disease is caused by loss of function of the ABCD1 transporter, involved in the import and degradation of very long-chain fatty acids (VLCFA) in peroxisomes.	long-chain fatty acids	115-137	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	49-54
21984583-1	2011	OBJECTIVE: Metabolism of long-chain fatty acids within the duodenum leads to the activation of duodenal mucosal protein kinase C (PKC)-delta and the cholecystokinin (CCK)-A receptor to lower glucose production through a neuronal network.	long-chain fatty acids	25-47	protein kinase C, delta	Rattus norvegicus	112-140
21984583-1	2011	OBJECTIVE: Metabolism of long-chain fatty acids within the duodenum leads to the activation of duodenal mucosal protein kinase C (PKC)-delta and the cholecystokinin (CCK)-A receptor to lower glucose production through a neuronal network.	long-chain fatty acids	25-47	cholecystokinin A receptor	Rattus norvegicus	149-181
21984583-3	2011	Although long-chain fatty acids activate PKC to stimulate the release of CCK in CCK-secreting cells, CCK has also been found to activate PKC-delta in pancreatic acinar cells.	long-chain fatty acids	9-31	protein kinase C, delta	Rattus norvegicus	41-44
21984583-3	2011	Although long-chain fatty acids activate PKC to stimulate the release of CCK in CCK-secreting cells, CCK has also been found to activate PKC-delta in pancreatic acinar cells.	long-chain fatty acids	9-31	cholecystokinin	Rattus norvegicus	73-76
21984583-3	2011	Although long-chain fatty acids activate PKC to stimulate the release of CCK in CCK-secreting cells, CCK has also been found to activate PKC-delta in pancreatic acinar cells.	long-chain fatty acids	9-31	cholecystokinin	Rattus norvegicus	80-83
21984583-3	2011	Although long-chain fatty acids activate PKC to stimulate the release of CCK in CCK-secreting cells, CCK has also been found to activate PKC-delta in pancreatic acinar cells.	long-chain fatty acids	9-31	cholecystokinin	Rattus norvegicus	80-83
21409596-1	2011	Hydroxysteroid (17beta) dehydrogenase type 12 (HSD17B12) is a multifunctional isoenzyme functional in the conversion of estrone to estradiol (E2), and elongation of long-chain fatty acids, in particular the conversion of palmitic to archadonic (AA) acid, the precursor of sterols and the inflammatory mediator, prostaglandin E(2).	long-chain fatty acids	165-187	hydroxysteroid 17-beta dehydrogenase 12	Homo sapiens	47-55
21908709-1	2011	Human fatty acid synthase (hFAS) is a homodimeric multidomain enzyme that catalyzes a series of reactions leading to the de novo biosynthesis of long-chain fatty acids, mainly palmitate.	long-chain fatty acids	145-167	fatty acid synthase	Homo sapiens	6-25
21801259-2	2011	Desaturase loci are involved in key biochemical changes in long-chain fatty acids.	long-chain fatty acids	59-81	Desaturase 1	Drosophila melanogaster	0-10
21586700-9	2011	In the GIP network combining data on GIP-infusion, EC+GIP and HC+GIP experiments, ghrelin was integrated into hormone-metabolite networks through a connection to a group of long-chain fatty acids.	long-chain fatty acids	173-195	gastric inhibitory polypeptide	Homo sapiens	7-10
21377536-0	2011	Biosynthesis of very long-chain fatty acids (C>24) in Atlantic salmon: cloning, functional characterisation, and tissue distribution of an Elovl4 elongase.	long-chain fatty acids	21-43	elongation of very long chain fatty acids-like 4	Salmo salar	142-148
21377536-2	2011	One member of the Elovl family, Elovl4, has been regarded as a critical enzyme in vertebrates in the production of the so-called very long-chain fatty acids (VLC-FA), a group of compounds that has been scarcely explored in fish.	long-chain fatty acids	134-156	elongation of very long chain fatty acids-like 4	Salmo salar	32-38
21508110-1	2011	PURPOSE: The S1 RNA binding domain 1 (SRBD1) and elongation of long-chain fatty acids family member 5 (ELOVL5) have been reported to be susceptibility genes for early-onset normal-tension glaucoma (NTG).	long-chain fatty acids	63-85	ELOVL fatty acid elongase 5	Homo sapiens	103-109