PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34688155-10	2021	The Hh signaling inhibitor cyclopamine, like wogonin, inhibited the colony formation of HT144 cells, however, the inhibitory effect of wogonin on colony formation of HT144 cells was abrogated by the Hh signaling agonist SAG.	cyclopamine	27-38	S-antigen visual arrestin	Homo sapiens	220-223
34755677-2	2021	METHODS: Cultured ANSCs were treated with purmorphamine (PM, an agonist of Smo) or cyclopamine (CPM, an inhibitor of Smo), and the changes in cell proliferation migration abilities were assessed using cell counting kit-8 (CCK8) assay and wound healing assay, respectively.	cyclopamine	83-94	smoothened, frizzled class receptor	Homo sapiens	117-120
34755677-2	2021	METHODS: Cultured ANSCs were treated with purmorphamine (PM, an agonist of Smo) or cyclopamine (CPM, an inhibitor of Smo), and the changes in cell proliferation migration abilities were assessed using cell counting kit-8 (CCK8) assay and wound healing assay, respectively.	cyclopamine	96-99	smoothened, frizzled class receptor	Homo sapiens	117-120
34579725-7	2021	With the help of cyclopamine to degrade the tumor associated matrix, this size-tunable gold wrapped immunoliposome was more likely to penetrate the deeper layers of the tumor, while the presence of gold nanoparticles makes GTSL-CYC-HER2 multimodal imaging feasible.	cyclopamine	17-28	cytochrome c, somatic	Homo sapiens	228-231
34592910-5	2022	Cyclopamine, a specific inhibitor of Shh, or saline was administered 12 h after MCAO surgery and lasted for 7 days.	cyclopamine	0-11	sonic hedgehog signaling molecule	Rattus norvegicus	37-40
34592910-10	2022	Treatment with cyclopamine can partially block the Shh signaling pathway, prevent myelin repair, and decrease the Olig1 expression following ischemic stroke.	cyclopamine	15-26	sonic hedgehog signaling molecule	Rattus norvegicus	51-54
34592910-10	2022	Treatment with cyclopamine can partially block the Shh signaling pathway, prevent myelin repair, and decrease the Olig1 expression following ischemic stroke.	cyclopamine	15-26	oligodendrocyte transcription factor 1	Rattus norvegicus	114-119
34579725-7	2021	With the help of cyclopamine to degrade the tumor associated matrix, this size-tunable gold wrapped immunoliposome was more likely to penetrate the deeper layers of the tumor, while the presence of gold nanoparticles makes GTSL-CYC-HER2 multimodal imaging feasible.	cyclopamine	17-28	erb-b2 receptor tyrosine kinase 2	Homo sapiens	232-236
34579725-10	2021	As for the in vivo experiments, compared to the other groups, under near-infrared laser irradiation, the temperature of GTSL-CYC-HER2 rises rapidly to the phase transition temperature, and released the cyclopamine locally in the tumor.	cyclopamine	202-213	cytochrome c, somatic	Homo sapiens	125-128
34579725-10	2021	As for the in vivo experiments, compared to the other groups, under near-infrared laser irradiation, the temperature of GTSL-CYC-HER2 rises rapidly to the phase transition temperature, and released the cyclopamine locally in the tumor.	cyclopamine	202-213	erb-b2 receptor tyrosine kinase 2	Homo sapiens	129-133
34155807-8	2021	Furthermore, simultaneous application of Shh pathway inhibitor cyclopamine proved that PB2 targets the Hh pathway.	cyclopamine	63-74	sonic hedgehog	Mus musculus	41-44
34534256-4	2021	Experiments using the sonic hedgehog (Shh) signaling inhibitor cyclopamine in vivo suggested that Shh signaling pathway was involved in the BE-induced undifferentiation process.	cyclopamine	63-74	sonic hedgehog	Mus musculus	22-36
34534256-4	2021	Experiments using the sonic hedgehog (Shh) signaling inhibitor cyclopamine in vivo suggested that Shh signaling pathway was involved in the BE-induced undifferentiation process.	cyclopamine	63-74	sonic hedgehog	Mus musculus	38-41
34534256-4	2021	Experiments using the sonic hedgehog (Shh) signaling inhibitor cyclopamine in vivo suggested that Shh signaling pathway was involved in the BE-induced undifferentiation process.	cyclopamine	63-74	sonic hedgehog	Mus musculus	98-101
34116113-10	2021	However, cyclopamine, a Smo inhibitor, canceled the above effects of resveratrol.	cyclopamine	9-20	smoothened, frizzled class receptor	Rattus norvegicus	24-27
34439999-7	2021	Our evidence suggests that modulation of the SHH effector smoothened (SMO), by using a known agonist (i.e., purmorphamine) and a known antagonist (i.e., cyclopamine), affects the CX43 expression levels and therefore the related functions.	cyclopamine	153-164	sonic hedgehog signaling molecule	Homo sapiens	45-48
34439999-7	2021	Our evidence suggests that modulation of the SHH effector smoothened (SMO), by using a known agonist (i.e., purmorphamine) and a known antagonist (i.e., cyclopamine), affects the CX43 expression levels and therefore the related functions.	cyclopamine	153-164	smoothened, frizzled class receptor	Homo sapiens	58-68
34439999-7	2021	Our evidence suggests that modulation of the SHH effector smoothened (SMO), by using a known agonist (i.e., purmorphamine) and a known antagonist (i.e., cyclopamine), affects the CX43 expression levels and therefore the related functions.	cyclopamine	153-164	smoothened, frizzled class receptor	Homo sapiens	70-73
34439999-7	2021	Our evidence suggests that modulation of the SHH effector smoothened (SMO), by using a known agonist (i.e., purmorphamine) and a known antagonist (i.e., cyclopamine), affects the CX43 expression levels and therefore the related functions.	cyclopamine	153-164	gap junction protein alpha 1	Homo sapiens	179-183
34440066-9	2021	Injection of the Shh agonist purmorphamine in undamaged fish induced a significant proliferative response, while the proliferative response was inhibited in injured fish treated with cyclopamine, a Shh antagonist.	cyclopamine	183-194	sonic hedgehog signaling molecule a	Danio rerio	198-201
34076346-3	2021	Cyclopamine (Cyp, a well-known inhibitor of SHH signaling pathway) and chloroquine (CQ, the pharmaceutical inhibitor of autophagy) were used in vivo and in vitro (autophagic flux, CCK-8 assay, wound healing assay, transwell assay, tumor xenograft model).	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	44-47
34210294-10	2021	Surprisingly, this dataset predicted that the Sonic Hedgehog (Shh) pathway inhibitor, cyclopamine, would mimic the effects of ethanol, despite ethanol not altering the expression levels of direct targets of Shh signaling.	cyclopamine	86-97	sonic hedgehog signaling molecule a	Danio rerio	46-60
34210294-10	2021	Surprisingly, this dataset predicted that the Sonic Hedgehog (Shh) pathway inhibitor, cyclopamine, would mimic the effects of ethanol, despite ethanol not altering the expression levels of direct targets of Shh signaling.	cyclopamine	86-97	sonic hedgehog signaling molecule a	Danio rerio	62-65
34076346-6	2021	Cyp induced autophagy through the PI3K/AKT signaling pathway.	cyclopamine	0-3	AKT serine/threonine kinase 1	Homo sapiens	39-42
34158608-7	2021	This conclusion was supported by the fact that WISP-1 activated the Hedgehog-Gli1 pathway in LF fibroblasts and that cyclopamine attenuated the effect of WISP-1-induced fibrogenesis.	cyclopamine	117-128	GLI family zinc finger 1	Homo sapiens	77-81
34164397-8	2021	Additionally, applying cyclopamine (CPE) to suppress Ihh was efficient to prevent NP cell apoptosis but did not decrease the ROS level.	cyclopamine	23-34	Indian hedgehog	Mus musculus	53-56
34306310-10	2021	Intriguingly, the inhibition of the Shh signaling pathway with cyclopamine significantly inhibited the protective effects of KXS on glutamate-induced neurotoxicity in PC12 cells.	cyclopamine	63-74	sonic hedgehog signaling molecule	Rattus norvegicus	36-39
35579188-7	2022	More importantly, we found that combination of hedgehog pathway inhibitor cyclopamine and chemotherapy revealed an improved anticancer effect in MUC21 overexpression xenograft model.	cyclopamine	74-85	mucin 21, cell surface associated	Homo sapiens	145-150
35584663-4	2022	INPP5E mutant organoids also show increased Sonic hedgehog (SHH) signaling, and cyclopamine treatment partially rescues this ventralization.	cyclopamine	80-91	inositol polyphosphate-5-phosphatase E	Homo sapiens	0-6
35266008-11	2022	Cyclopamine treatment was found to arrest 786-O cells in the G2/M phase and decreased the expression levels of GLI1, BCL2, VEGFA and CCND1.	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	111-115
35521940-6	2022	The SMO inhibitor cyclopamine significantly decreased cell viability and colony-forming ability in the canine OSA cell lines in a dose-dependent manner.	cyclopamine	18-29	smoothened, frizzled class receptor	Canis lupus familiaris	4-7
35521940-7	2022	Moresco cells, which expressed the highest level of SMO protein, were the most sensitive to the anticancer effect of cyclopamine among the three canine OSA cell lines tested.	cyclopamine	117-128	smoothened, frizzled class receptor	Canis lupus familiaris	52-55
35521940-10	2022	The findings that Hh/SMO is activated in canine OSA cell lines and cyclopamine suppresses OSA cell survival via inhibition of SMO suggest that the Hh/SMO signaling pathway might be a novel therapeutic target for canine OSA.	cyclopamine	67-78	smoothened, frizzled class receptor	Homo sapiens	126-129
35521940-10	2022	The findings that Hh/SMO is activated in canine OSA cell lines and cyclopamine suppresses OSA cell survival via inhibition of SMO suggest that the Hh/SMO signaling pathway might be a novel therapeutic target for canine OSA.	cyclopamine	67-78	smoothened, frizzled class receptor	Homo sapiens	150-153
35266008-11	2022	Cyclopamine treatment was found to arrest 786-O cells in the G2/M phase and decreased the expression levels of GLI1, BCL2, VEGFA and CCND1.	cyclopamine	0-11	BCL2 apoptosis regulator	Homo sapiens	117-121
35266008-11	2022	Cyclopamine treatment was found to arrest 786-O cells in the G2/M phase and decreased the expression levels of GLI1, BCL2, VEGFA and CCND1.	cyclopamine	0-11	vascular endothelial growth factor A	Homo sapiens	123-128
35266008-11	2022	Cyclopamine treatment was found to arrest 786-O cells in the G2/M phase and decreased the expression levels of GLI1, BCL2, VEGFA and CCND1.	cyclopamine	0-11	cyclin D1	Homo sapiens	133-138
35119381-8	2022	Furthermore, the proliferation of SG3 in the presence of mOlDhh could be inhibited by Smo antagonist (Cyclopamine) resulting in apoptosis.	cyclopamine	102-113	smoothened homolog	Oryzias latipes	86-89
35203385-4	2022	To this end, we simulated an inflammatory environment in vitro using lipopolysaccharide (LPS) and induced the Shh-pathway using recombinant Shh or blocked it using Cyclopamine, a potent Smo inhibitor.	cyclopamine	164-175	sonic hedgehog signaling molecule	Homo sapiens	110-113
35203385-6	2022	At the same time, our results indicate that a reduction of the Shh-pathway activation by blockage with Cyclopamine is associated with reduced NPC-survival, reduced neuronal differentiation and increased astroglial differentiation.	cyclopamine	103-114	sonic hedgehog signaling molecule	Homo sapiens	63-66
33717417-6	2021	Transcription of foxa2 is positively regulated by Sonic Hedgehog (SHH), and treatment of cyclopamine, an SHH inhibitor, represses transcription of foxa2 in 4 hpf through 24 hpf embryos.	cyclopamine	89-100	forkhead box A2	Danio rerio	17-22
33966040-2	2021	Our recent study showed that the inhibitors of the Shh pathway such as cyclopamine (CP), a Smothened (SMO) inhibitor, and GANT61, a Gli1 inhibitor, have modest inhibitory effects on thyroid tumor cell proliferation and tumor growth.	cyclopamine	71-82	sonic hedgehog signaling molecule	Homo sapiens	51-54
33966040-4	2021	Here we report that inhibition of the Shh pathway by Gli1 siRNA or by cyclopamine and GANT61 induced autophagy in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines; whereas Gli1 overexpression suppressed autophagy.	cyclopamine	70-81	sonic hedgehog signaling molecule	Homo sapiens	38-41
33732371-0	2021	Cyclopamine sensitizes multiple myeloma cells to circularly permuted TRAIL-induced apoptosis.	cyclopamine	0-11	TNF superfamily member 10	Homo sapiens	69-74
33732371-10	2021	Quantitative PCR showed that cyclopamine decreased the mRNA expression levels of GLI1/GLI2/GLI3 and increased the expression levels of death receptor 4.	cyclopamine	29-40	GLI family zinc finger 1	Homo sapiens	81-85
33732371-10	2021	Quantitative PCR showed that cyclopamine decreased the mRNA expression levels of GLI1/GLI2/GLI3 and increased the expression levels of death receptor 4.	cyclopamine	29-40	GLI family zinc finger 2	Homo sapiens	86-95
33732371-10	2021	Quantitative PCR showed that cyclopamine decreased the mRNA expression levels of GLI1/GLI2/GLI3 and increased the expression levels of death receptor 4.	cyclopamine	29-40	TNF receptor superfamily member 10a	Homo sapiens	135-151
34006832-6	2021	Cyclopamine, as a specific SMO inhibitor, was incubated with BPH-1 and WPMY-1, and intraperitoneally injected into a BPH rat model established by castration with testosterone supplementation.	cyclopamine	0-11	smoothened, frizzled class receptor	Rattus norvegicus	27-30
33717417-6	2021	Transcription of foxa2 is positively regulated by Sonic Hedgehog (SHH), and treatment of cyclopamine, an SHH inhibitor, represses transcription of foxa2 in 4 hpf through 24 hpf embryos.	cyclopamine	89-100	sonic hedgehog signaling molecule a	Danio rerio	66-69
33717417-6	2021	Transcription of foxa2 is positively regulated by Sonic Hedgehog (SHH), and treatment of cyclopamine, an SHH inhibitor, represses transcription of foxa2 in 4 hpf through 24 hpf embryos.	cyclopamine	89-100	sonic hedgehog signaling molecule a	Danio rerio	105-108
33717417-6	2021	Transcription of foxa2 is positively regulated by Sonic Hedgehog (SHH), and treatment of cyclopamine, an SHH inhibitor, represses transcription of foxa2 in 4 hpf through 24 hpf embryos.	cyclopamine	89-100	forkhead box A2	Danio rerio	147-152
33717417-8	2021	Finally, spatiotemporal expression patterns of a midbrain marker otx2b in the developmental defects confirmed inhibition of SHH by cyclopamine caused underdevelopment of the midbrain and MHB at 24 hpf.	cyclopamine	131-142	sonic hedgehog signaling molecule a	Danio rerio	124-127
33135420-13	2020	An inhibitor (cyclopamine) of Ihh/PTHrP signalling pathway inhibited the proliferation and restored the differentiation of chondrocytes in MUT group.	cyclopamine	14-25	Indian hedgehog signaling molecule	Homo sapiens	30-33
33617370-7	2021	Cyclopamine (Shh inhibitor) and LY294002 (PI3K inhibitor) showed the similar toxic effects as EGCG on colon cancer cells.	cyclopamine	0-11	sonic hedgehog	Mus musculus	13-16
33127578-12	2021	Supplementation with cyclopamine suppressed PTHrP/PTH1R signalling and inhibited ATDC5 cell proliferation and differentiation.	cyclopamine	21-32	parathyroid hormone-like peptide	Mus musculus	44-49
33127578-12	2021	Supplementation with cyclopamine suppressed PTHrP/PTH1R signalling and inhibited ATDC5 cell proliferation and differentiation.	cyclopamine	21-32	parathyroid hormone 1 receptor	Mus musculus	50-55
33616621-8	2021	Smo antagonist, cyclopamine, reduced cell numbers, and the expression of Ki67 in MGECM, and promoted the expression of SREBP1 and lipid production in DM + AZM.	cyclopamine	16-27	smoothened, frizzled class receptor	Rattus norvegicus	0-3
33499351-6	2021	Here we report that inhibition of the Shh pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.	cyclopamine	70-81	sonic hedgehog signaling molecule	Homo sapiens	38-41
33499351-6	2021	Here we report that inhibition of the Shh pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.	cyclopamine	70-81	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	101-105
33499351-6	2021	Here we report that inhibition of the Shh pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.	cyclopamine	70-81	SRY-box transcription factor 2	Homo sapiens	110-114
33380787-4	2020	Methods: Here, we prepared liposomes loaded with curcumin and cyclopamine to inhibit HSC activation.	cyclopamine	62-73	fucosyltransferase 1 (H blood group)	Homo sapiens	85-88
33343302-6	2020	Methods: Cyclopamine (CYC) is a potent, selective inhibitor that specifically blocks the SHH signaling pathway.	cyclopamine	9-20	sonic hedgehog	Mus musculus	89-92
33343302-6	2020	Methods: Cyclopamine (CYC) is a potent, selective inhibitor that specifically blocks the SHH signaling pathway.	cyclopamine	22-25	sonic hedgehog	Mus musculus	89-92
33343302-9	2020	Compared with the vehicle-treated group, inhibition of the SHH signaling pathway with CYC and its derivatives treatments aggravated neurological function deficits, brain edema, hematoma volume, and BBB impairment by downregulating TJs in ECs through the SHH-Gli-1 axis in vivo and in vitro.	cyclopamine	86-89	sonic hedgehog	Mus musculus	59-62
33343302-9	2020	Compared with the vehicle-treated group, inhibition of the SHH signaling pathway with CYC and its derivatives treatments aggravated neurological function deficits, brain edema, hematoma volume, and BBB impairment by downregulating TJs in ECs through the SHH-Gli-1 axis in vivo and in vitro.	cyclopamine	86-89	sonic hedgehog	Mus musculus	254-257
33343302-9	2020	Compared with the vehicle-treated group, inhibition of the SHH signaling pathway with CYC and its derivatives treatments aggravated neurological function deficits, brain edema, hematoma volume, and BBB impairment by downregulating TJs in ECs through the SHH-Gli-1 axis in vivo and in vitro.	cyclopamine	86-89	GLI-Kruppel family member GLI1	Mus musculus	258-263
33649337-3	2021	Using transgenic eGFP mice and genetic lineage tracing of S100beta vSCs in vivo, we identified S100beta/Sca1 cells derived from a S100beta non-SMC parent population within lesions that co-localise with smooth muscle alpha-actin (SMA) cells following iatrogenic flow restriction, an effect attenuated following hedgehog inhibition with the smoothened inhibitor, cyclopamine.	cyclopamine	361-372	S100 calcium binding protein A1	Mus musculus	95-103
33649337-3	2021	Using transgenic eGFP mice and genetic lineage tracing of S100beta vSCs in vivo, we identified S100beta/Sca1 cells derived from a S100beta non-SMC parent population within lesions that co-localise with smooth muscle alpha-actin (SMA) cells following iatrogenic flow restriction, an effect attenuated following hedgehog inhibition with the smoothened inhibitor, cyclopamine.	cyclopamine	361-372	ataxin 1	Mus musculus	104-108
33649337-3	2021	Using transgenic eGFP mice and genetic lineage tracing of S100beta vSCs in vivo, we identified S100beta/Sca1 cells derived from a S100beta non-SMC parent population within lesions that co-localise with smooth muscle alpha-actin (SMA) cells following iatrogenic flow restriction, an effect attenuated following hedgehog inhibition with the smoothened inhibitor, cyclopamine.	cyclopamine	361-372	S100 calcium binding protein A1	Mus musculus	95-103
33748811-11	2021	Upregulation of Shh signaling with Smoothened agonist (SAG) results in an increase of newly proliferating cells expressing glial fibrillary acidic protein (GFAP), whereas the Shh signaling inhibitor cyclopamine leads to a reduction.	cyclopamine	199-210	sonic hedgehog signaling molecule	Homo sapiens	16-19
33748811-11	2021	Upregulation of Shh signaling with Smoothened agonist (SAG) results in an increase of newly proliferating cells expressing glial fibrillary acidic protein (GFAP), whereas the Shh signaling inhibitor cyclopamine leads to a reduction.	cyclopamine	199-210	sonic hedgehog signaling molecule	Homo sapiens	175-178
32777528-5	2020	We have previously reported that the inhibitor of Hh, cyclopamine, reduces the metastatic activity of MGC-803 via inhibiting the expression of matrix metalloproteinases (MMP)-9.	cyclopamine	54-65	matrix metallopeptidase 9	Homo sapiens	143-176
33135420-13	2020	An inhibitor (cyclopamine) of Ihh/PTHrP signalling pathway inhibited the proliferation and restored the differentiation of chondrocytes in MUT group.	cyclopamine	14-25	parathyroid hormone like hormone	Homo sapiens	34-39
33080820-6	2020	To this end we performed a scratch assay in the presence of the smoothened (SMO) antagonist cyclopamine (cyclo) or CAs inhibitors under normoxia or hypoxia.	cyclopamine	92-103	smoothened, frizzled class receptor	Homo sapiens	76-79
32383186-6	2020	Targeting of smoothened (SMO), a key protein in the SHH pathway, using the small molecule inhibitor Cyclopamine partially reversed the increased proliferation, colony formation and migration in PAX8-GLIS3 expressing cells.	cyclopamine	100-111	smoothened, frizzled class receptor	Homo sapiens	13-23
32383186-6	2020	Targeting of smoothened (SMO), a key protein in the SHH pathway, using the small molecule inhibitor Cyclopamine partially reversed the increased proliferation, colony formation and migration in PAX8-GLIS3 expressing cells.	cyclopamine	100-111	smoothened, frizzled class receptor	Homo sapiens	25-28
32383186-6	2020	Targeting of smoothened (SMO), a key protein in the SHH pathway, using the small molecule inhibitor Cyclopamine partially reversed the increased proliferation, colony formation and migration in PAX8-GLIS3 expressing cells.	cyclopamine	100-111	sonic hedgehog signaling molecule	Homo sapiens	52-55
32383186-6	2020	Targeting of smoothened (SMO), a key protein in the SHH pathway, using the small molecule inhibitor Cyclopamine partially reversed the increased proliferation, colony formation and migration in PAX8-GLIS3 expressing cells.	cyclopamine	100-111	paired box 8	Homo sapiens	194-198
32383186-6	2020	Targeting of smoothened (SMO), a key protein in the SHH pathway, using the small molecule inhibitor Cyclopamine partially reversed the increased proliferation, colony formation and migration in PAX8-GLIS3 expressing cells.	cyclopamine	100-111	GLIS family zinc finger 3	Homo sapiens	199-204
33080820-6	2020	To this end we performed a scratch assay in the presence of the smoothened (SMO) antagonist cyclopamine (cyclo) or CAs inhibitors under normoxia or hypoxia.	cyclopamine	92-97	smoothened, frizzled class receptor	Homo sapiens	76-79
32622951-0	2020	Cyclopamine sensitizes glioblastoma cells to temozolomide treatment through Sonic hedgehog pathway.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	76-90
32622951-4	2020	Here, we investigated if the inhibitor of the Sonic hedgehog pathway, cyclopamine, could potentiate the temozolomide effect in cancer stem-like cells and glioblastoma cell lines in vitro.	cyclopamine	70-81	sonic hedgehog signaling molecule	Homo sapiens	46-60
32622951-8	2020	Cyclopamine potentiated temozolomide treatment in glioblastoma cell lines by inducing apoptosis through activation of caspase-3 cleaved.	cyclopamine	0-11	caspase 3	Homo sapiens	118-127
32622951-9	2020	Conversely, the combined treatment of cyclopamine and temozolomide potentiated the stemness properties of glioblastoma cells by inducing the expression of SOX-2 and OCT-4.	cyclopamine	38-49	SRY-box transcription factor 2	Homo sapiens	155-160
32622951-9	2020	Conversely, the combined treatment of cyclopamine and temozolomide potentiated the stemness properties of glioblastoma cells by inducing the expression of SOX-2 and OCT-4.	cyclopamine	38-49	POU class 5 homeobox 1	Homo sapiens	165-170
32542407-6	2020	Expression of procollagen type IV, alpha 1 (Col4a1) in organ-cultured ovaries was significantly reduced by CPA, but not by DES.	cyclopamine	107-110	collagen, type IV, alpha 1	Mus musculus	14-42
32542407-6	2020	Expression of procollagen type IV, alpha 1 (Col4a1) in organ-cultured ovaries was significantly reduced by CPA, but not by DES.	cyclopamine	107-110	collagen, type IV, alpha 1	Mus musculus	44-50
32751882-0	2020	Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver.	cyclopamine	0-11	mechanistic target of rapamycin kinase	Mus musculus	50-54
32802036-5	2020	Treatment with purmorphamine, a Shh agonist, increased Gli-1 in the nucleus of neurons and protected against OGD injury, whereas the Shh inhibitor, cyclopamine, produced the opposite effects.	cyclopamine	148-159	sonic hedgehog signaling molecule	Rattus norvegicus	133-136
32751882-0	2020	Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver.	cyclopamine	0-11	mechanistic target of rapamycin kinase	Mus musculus	129-133
32751882-7	2020	Furthermore, in vitro studies show a synergistic effect of cyclopamine and rapamycin on the inhibition of mTor signalling and oxidative respiration in primary hepatocytes from male and female C57BL/6N mice.	cyclopamine	59-70	mechanistic target of rapamycin kinase	Mus musculus	106-110
32735563-9	2020	Additionally, although treatment of zebrafish larvae with Shh inhibitor cyclopamine results in BRB breakdown, the Ift mutant fish were not sensitized to cyclopamine-induced BRB breakdown.	cyclopamine	72-83	sonic hedgehog signaling molecule a	Danio rerio	58-61
32319534-9	2020	In response to cyclopamine treatment, epithelial and stromal cell proliferation was inhibited; this was concomitant with decreased Ki67, TGF-beta, and b-FGF expression.	cyclopamine	15-26	transforming growth factor alpha	Rattus norvegicus	137-145
32298032-8	2020	Cyclopamine (CPN) was observed to block the Shh signaling induced by high glucose, accompanied by cell migration inhibition, decreased expression of alpha-SMA, fibronectin, collagen I and snail1 as well as increased expression of E-cadherin.	cyclopamine	0-11	sonic hedgehog signaling molecule	Rattus norvegicus	44-47
32298032-8	2020	Cyclopamine (CPN) was observed to block the Shh signaling induced by high glucose, accompanied by cell migration inhibition, decreased expression of alpha-SMA, fibronectin, collagen I and snail1 as well as increased expression of E-cadherin.	cyclopamine	0-11	fibronectin 1	Rattus norvegicus	160-171
32298032-8	2020	Cyclopamine (CPN) was observed to block the Shh signaling induced by high glucose, accompanied by cell migration inhibition, decreased expression of alpha-SMA, fibronectin, collagen I and snail1 as well as increased expression of E-cadherin.	cyclopamine	0-11	cadherin 1	Rattus norvegicus	230-240
32298032-8	2020	Cyclopamine (CPN) was observed to block the Shh signaling induced by high glucose, accompanied by cell migration inhibition, decreased expression of alpha-SMA, fibronectin, collagen I and snail1 as well as increased expression of E-cadherin.	cyclopamine	13-16	sonic hedgehog signaling molecule	Rattus norvegicus	44-47
32298032-8	2020	Cyclopamine (CPN) was observed to block the Shh signaling induced by high glucose, accompanied by cell migration inhibition, decreased expression of alpha-SMA, fibronectin, collagen I and snail1 as well as increased expression of E-cadherin.	cyclopamine	13-16	fibronectin 1	Rattus norvegicus	160-171
32298032-8	2020	Cyclopamine (CPN) was observed to block the Shh signaling induced by high glucose, accompanied by cell migration inhibition, decreased expression of alpha-SMA, fibronectin, collagen I and snail1 as well as increased expression of E-cadherin.	cyclopamine	13-16	cadherin 1	Rattus norvegicus	230-240
32723329-8	2020	RESULTS: Specific antagonists (cyclopamine and GANT61) of the Hh pathway down-regulated TPX2, whereas activation of Hh signaling stimulated TPX2 expression.	cyclopamine	31-42	TPX2, microtubule-associated S homeolog	Xenopus laevis	88-92
32765048-9	2020	Cyclopamine attenuated hyperalgesia and down-regulated the expressions of Gil1, BDNF, p-TrkB, p-PI3K and p-Akt in CPTP rats.	cyclopamine	0-11	brain-derived neurotrophic factor	Rattus norvegicus	80-84
32765048-9	2020	Cyclopamine attenuated hyperalgesia and down-regulated the expressions of Gil1, BDNF, p-TrkB, p-PI3K and p-Akt in CPTP rats.	cyclopamine	0-11	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	88-92
32765048-9	2020	Cyclopamine attenuated hyperalgesia and down-regulated the expressions of Gil1, BDNF, p-TrkB, p-PI3K and p-Akt in CPTP rats.	cyclopamine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
32319534-9	2020	In response to cyclopamine treatment, epithelial and stromal cell proliferation was inhibited; this was concomitant with decreased Ki67, TGF-beta, and b-FGF expression.	cyclopamine	15-26	fibroblast growth factor 2	Rattus norvegicus	151-156
32449381-7	2021	Additionally, canonical Shh cascade was further blocked in LAMA4-overexpressed fibroblasts by cyclopamine, and the changes in cellular proliferation and migration were investigated.	cyclopamine	94-105	sonic hedgehog protein	Oryctolagus cuniculus	24-27
32670287-9	2020	We observed that treatment of SHH agonist (SAG) significantly increased the levels of phosphorylation of JNK and c-Jun, while SHH antagonist (cyclopamine) significantly decreased the expression of phospho-JNK and phospho-c-Jun in FLSs.	cyclopamine	142-153	sonic hedgehog signaling molecule	Homo sapiens	126-129
32670287-9	2020	We observed that treatment of SHH agonist (SAG) significantly increased the levels of phosphorylation of JNK and c-Jun, while SHH antagonist (cyclopamine) significantly decreased the expression of phospho-JNK and phospho-c-Jun in FLSs.	cyclopamine	142-153	mitogen-activated protein kinase 8	Homo sapiens	205-208
32670287-9	2020	We observed that treatment of SHH agonist (SAG) significantly increased the levels of phosphorylation of JNK and c-Jun, while SHH antagonist (cyclopamine) significantly decreased the expression of phospho-JNK and phospho-c-Jun in FLSs.	cyclopamine	142-153	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	221-226
32449865-9	2021	Compared with that in the PN-1 siRNA + cyclopamine + Abeta1-42 group, apoptosis of HT22 cells in the cyclopamine + Abeta1-42 group was reduced and cell viability was improved.Conclusion: PN-1, by blocking SHH pathway, reduced apoptosis of hippocampal neurons to improve spatial learning and memory ability, thereby playing a protective role in AD.	cyclopamine	39-50	serine (or cysteine) peptidase inhibitor, clade E, member 2	Mus musculus	26-30
32449865-9	2021	Compared with that in the PN-1 siRNA + cyclopamine + Abeta1-42 group, apoptosis of HT22 cells in the cyclopamine + Abeta1-42 group was reduced and cell viability was improved.Conclusion: PN-1, by blocking SHH pathway, reduced apoptosis of hippocampal neurons to improve spatial learning and memory ability, thereby playing a protective role in AD.	cyclopamine	39-50	serine (or cysteine) peptidase inhibitor, clade E, member 2	Mus musculus	187-191
32449865-9	2021	Compared with that in the PN-1 siRNA + cyclopamine + Abeta1-42 group, apoptosis of HT22 cells in the cyclopamine + Abeta1-42 group was reduced and cell viability was improved.Conclusion: PN-1, by blocking SHH pathway, reduced apoptosis of hippocampal neurons to improve spatial learning and memory ability, thereby playing a protective role in AD.	cyclopamine	39-50	sonic hedgehog	Mus musculus	205-208
32449865-9	2021	Compared with that in the PN-1 siRNA + cyclopamine + Abeta1-42 group, apoptosis of HT22 cells in the cyclopamine + Abeta1-42 group was reduced and cell viability was improved.Conclusion: PN-1, by blocking SHH pathway, reduced apoptosis of hippocampal neurons to improve spatial learning and memory ability, thereby playing a protective role in AD.	cyclopamine	101-112	serine (or cysteine) peptidase inhibitor, clade E, member 2	Mus musculus	26-30
32449865-9	2021	Compared with that in the PN-1 siRNA + cyclopamine + Abeta1-42 group, apoptosis of HT22 cells in the cyclopamine + Abeta1-42 group was reduced and cell viability was improved.Conclusion: PN-1, by blocking SHH pathway, reduced apoptosis of hippocampal neurons to improve spatial learning and memory ability, thereby playing a protective role in AD.	cyclopamine	101-112	serine (or cysteine) peptidase inhibitor, clade E, member 2	Mus musculus	187-191
32449865-9	2021	Compared with that in the PN-1 siRNA + cyclopamine + Abeta1-42 group, apoptosis of HT22 cells in the cyclopamine + Abeta1-42 group was reduced and cell viability was improved.Conclusion: PN-1, by blocking SHH pathway, reduced apoptosis of hippocampal neurons to improve spatial learning and memory ability, thereby playing a protective role in AD.	cyclopamine	101-112	sonic hedgehog	Mus musculus	205-208
32449381-7	2021	Additionally, canonical Shh cascade was further blocked in LAMA4-overexpressed fibroblasts by cyclopamine, and the changes in cellular proliferation and migration were investigated.	cyclopamine	94-105	LAMA4	Oryctolagus cuniculus	59-64
32449381-11	2021	Intriguingly, blockage of Shh/Gli1 signaling with cyclopamine reversed the promoting effects of LAMA4 on proliferation and migration of fibroblasts.	cyclopamine	50-61	sonic hedgehog protein	Oryctolagus cuniculus	26-29
32449381-11	2021	Intriguingly, blockage of Shh/Gli1 signaling with cyclopamine reversed the promoting effects of LAMA4 on proliferation and migration of fibroblasts.	cyclopamine	50-61	zinc finger protein GLI1	Oryctolagus cuniculus	30-34
32449381-11	2021	Intriguingly, blockage of Shh/Gli1 signaling with cyclopamine reversed the promoting effects of LAMA4 on proliferation and migration of fibroblasts.	cyclopamine	50-61	LAMA4	Oryctolagus cuniculus	96-101
32194421-7	2020	PUR upregulated the expression of Shh pathway mediators, while suppression of the Shh signaling pathway with cyclopamine (Cyc) reversed these beneficial effects of PUR on HI insult.	cyclopamine	109-120	sonic hedgehog	Mus musculus	82-85
32326611-3	2020	Here, we found that cyclopamine (smoothened (Smo) inhibitor), GANT-58 (GLI1 inhibitor), or GANT-61 (GLI1/2 inhibitor) significantly inhibited RANKL-induced osteoclast differentiation of bone marrow-derived macrophages.	cyclopamine	20-31	smoothened, frizzled class receptor	Mus musculus	33-43
32326611-3	2020	Here, we found that cyclopamine (smoothened (Smo) inhibitor), GANT-58 (GLI1 inhibitor), or GANT-61 (GLI1/2 inhibitor) significantly inhibited RANKL-induced osteoclast differentiation of bone marrow-derived macrophages.	cyclopamine	20-31	smoothened, frizzled class receptor	Mus musculus	45-48
32326611-3	2020	Here, we found that cyclopamine (smoothened (Smo) inhibitor), GANT-58 (GLI1 inhibitor), or GANT-61 (GLI1/2 inhibitor) significantly inhibited RANKL-induced osteoclast differentiation of bone marrow-derived macrophages.	cyclopamine	20-31	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	142-147
32319512-10	2020	Furthermore, treatment with miR-132/212 mimics obviously increased the protein expression of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP), which was decreased after treatment with Hedgehog signaling inhibitor, cyclopamine.	cyclopamine	235-246	microRNA 132	Homo sapiens	28-35
32319512-10	2020	Furthermore, treatment with miR-132/212 mimics obviously increased the protein expression of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP), which was decreased after treatment with Hedgehog signaling inhibitor, cyclopamine.	cyclopamine	235-246	Indian hedgehog signaling molecule	Homo sapiens	93-108
32319512-10	2020	Furthermore, treatment with miR-132/212 mimics obviously increased the protein expression of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP), which was decreased after treatment with Hedgehog signaling inhibitor, cyclopamine.	cyclopamine	235-246	Indian hedgehog signaling molecule	Homo sapiens	110-113
32319512-10	2020	Furthermore, treatment with miR-132/212 mimics obviously increased the protein expression of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP), which was decreased after treatment with Hedgehog signaling inhibitor, cyclopamine.	cyclopamine	235-246	parathyroid hormone like hormone	Homo sapiens	119-154
32319512-10	2020	Furthermore, treatment with miR-132/212 mimics obviously increased the protein expression of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP), which was decreased after treatment with Hedgehog signaling inhibitor, cyclopamine.	cyclopamine	235-246	parathyroid hormone like hormone	Homo sapiens	156-161
32319512-11	2020	We also found that inhibition of Ihh/PTHrP signaling by cyclopamine significantly suppressed growth and DNA synthesis, and induced apoptosis in PCSCs.	cyclopamine	56-67	Indian hedgehog signaling molecule	Homo sapiens	33-36
32319512-11	2020	We also found that inhibition of Ihh/PTHrP signaling by cyclopamine significantly suppressed growth and DNA synthesis, and induced apoptosis in PCSCs.	cyclopamine	56-67	parathyroid hormone like hormone	Homo sapiens	37-42
32194421-7	2020	PUR upregulated the expression of Shh pathway mediators, while suppression of the Shh signaling pathway with cyclopamine (Cyc) reversed these beneficial effects of PUR on HI insult.	cyclopamine	122-125	sonic hedgehog	Mus musculus	82-85
32343239-8	2020	Both lanthanum citrate and KAAD-cyclopamine downregulated the protein expressions of CyclinD1, Bcl-2, Gli1, and Shh and upregulated the protein expressions of p21 and Caspase-3.	cyclopamine	32-43	cyclin D1	Homo sapiens	85-93
32343239-8	2020	Both lanthanum citrate and KAAD-cyclopamine downregulated the protein expressions of CyclinD1, Bcl-2, Gli1, and Shh and upregulated the protein expressions of p21 and Caspase-3.	cyclopamine	32-43	BCL2 apoptosis regulator	Homo sapiens	95-100
32343239-8	2020	Both lanthanum citrate and KAAD-cyclopamine downregulated the protein expressions of CyclinD1, Bcl-2, Gli1, and Shh and upregulated the protein expressions of p21 and Caspase-3.	cyclopamine	32-43	GLI family zinc finger 1	Homo sapiens	102-106
32343239-8	2020	Both lanthanum citrate and KAAD-cyclopamine downregulated the protein expressions of CyclinD1, Bcl-2, Gli1, and Shh and upregulated the protein expressions of p21 and Caspase-3.	cyclopamine	32-43	sonic hedgehog signaling molecule	Homo sapiens	112-115
32343239-8	2020	Both lanthanum citrate and KAAD-cyclopamine downregulated the protein expressions of CyclinD1, Bcl-2, Gli1, and Shh and upregulated the protein expressions of p21 and Caspase-3.	cyclopamine	32-43	cyclin dependent kinase inhibitor 1A	Homo sapiens	159-162
32343239-9	2020	Additionally, the immunofluorescence results revealed that the protein expressions of Gli1 and Shh were significantly decreased in both the lanthanum citrate group and the KAAD-cyclopamine group compared to the control group.	cyclopamine	177-188	GLI family zinc finger 1	Homo sapiens	86-90
32343239-9	2020	Additionally, the immunofluorescence results revealed that the protein expressions of Gli1 and Shh were significantly decreased in both the lanthanum citrate group and the KAAD-cyclopamine group compared to the control group.	cyclopamine	177-188	sonic hedgehog signaling molecule	Homo sapiens	95-98
32074731-1	2020	Objective: To investigate the change and association of glioma-associated oncogene homolog 1 (Gli1) and beta-catenin on bone formation in rats with chronic fluorosis which were inhibited by cyclopamine (Cycl).	cyclopamine	190-201	GLI family zinc finger 1	Rattus norvegicus	94-98
32074731-1	2020	Objective: To investigate the change and association of glioma-associated oncogene homolog 1 (Gli1) and beta-catenin on bone formation in rats with chronic fluorosis which were inhibited by cyclopamine (Cycl).	cyclopamine	190-201	catenin beta 1	Rattus norvegicus	104-116
32074731-12	2020	The expression of Gli1 and beta-catenin mRNA and protein was higher in the F and F+Cycl groups than controls, but lower in the F+Cycl group than in the F group.	cyclopamine	83-87	GLI family zinc finger 1	Rattus norvegicus	18-22
32074731-12	2020	The expression of Gli1 and beta-catenin mRNA and protein was higher in the F and F+Cycl groups than controls, but lower in the F+Cycl group than in the F group.	cyclopamine	83-87	catenin beta 1	Rattus norvegicus	27-39
32074731-12	2020	The expression of Gli1 and beta-catenin mRNA and protein was higher in the F and F+Cycl groups than controls, but lower in the F+Cycl group than in the F group.	cyclopamine	129-133	GLI family zinc finger 1	Rattus norvegicus	18-22
32074731-12	2020	The expression of Gli1 and beta-catenin mRNA and protein was higher in the F and F+Cycl groups than controls, but lower in the F+Cycl group than in the F group.	cyclopamine	129-133	catenin beta 1	Rattus norvegicus	27-39
32074731-15	2020	Conclusions: The expression of Gli1 can be inhibited by Cycl.	cyclopamine	56-60	GLI family zinc finger 1	Rattus norvegicus	31-35
31707356-0	2020	A NanoBRET-based binding assay for Smoothened allows real time analysis of ligand binding and distinction of two binding sites for BODIPY-cyclopamine.	cyclopamine	131-149	smoothened, frizzled class receptor	Homo sapiens	35-45
31708014-8	2020	Our results show that use of the Hedgehog pathway Smoothened Agonist (SAG) HCl and antagonists cyclopamine and gant6 affects the expression levels of Glioma-Associated Oncogene Homolog 1 (Gli1), Ccnd2 and other genes in this pathway.	cyclopamine	95-106	GLI-Kruppel family member GLI1	Mus musculus	188-192
31708014-8	2020	Our results show that use of the Hedgehog pathway Smoothened Agonist (SAG) HCl and antagonists cyclopamine and gant6 affects the expression levels of Glioma-Associated Oncogene Homolog 1 (Gli1), Ccnd2 and other genes in this pathway.	cyclopamine	95-106	cyclin D2	Mus musculus	195-200
32161016-10	2020	As compared with the control group, different doses of cyclopamine (0.3, 3 and 10 mg/l) significantly decreased the expression of Shh, Ptch1 and Gli1 proteins in AA chondrocytes.	cyclopamine	55-66	sonic hedgehog signaling molecule	Rattus norvegicus	130-133
32161016-10	2020	As compared with the control group, different doses of cyclopamine (0.3, 3 and 10 mg/l) significantly decreased the expression of Shh, Ptch1 and Gli1 proteins in AA chondrocytes.	cyclopamine	55-66	patched 1	Rattus norvegicus	135-140
32161016-10	2020	As compared with the control group, different doses of cyclopamine (0.3, 3 and 10 mg/l) significantly decreased the expression of Shh, Ptch1 and Gli1 proteins in AA chondrocytes.	cyclopamine	55-66	GLI family zinc finger 1	Rattus norvegicus	145-149
31707356-5	2020	In the NanoBRET-based binding assay, SMO is N-terminally tagged with nanoluciferase (Nluc) and binding of BODIPY-cyclopamine is assessed by quantifying resonance energy transfer between receptor and ligand.	cyclopamine	106-124	smoothened, frizzled class receptor	Homo sapiens	37-40
31707356-9	2020	This assay allows distinction of two separate binding sites for BODIPY-cyclopamine on SMO transmembrane core in live cells in real time.	cyclopamine	64-82	smoothened, frizzled class receptor	Homo sapiens	86-89
31461626-7	2019	Likewise, pharmacologic inhibition of Shh signaling with cyclopamine also hindered fibroblast activation and exacerbated kidney damage.	cyclopamine	57-68	sonic hedgehog	Mus musculus	38-41
31634481-6	2019	Cyclopamine treatment suppressed hypoxia induced SHH pathway activation, consequently reducing invasiveness by downregulating the expression of CSC transcription factors, CD133 and EMT.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	49-52
31634481-6	2019	Cyclopamine treatment suppressed hypoxia induced SHH pathway activation, consequently reducing invasiveness by downregulating the expression of CSC transcription factors, CD133 and EMT.	cyclopamine	0-11	prominin 1	Homo sapiens	171-176
31634481-7	2019	Cyclopamine induced apoptosis in CC cells under hypoxia, suggesting that hypoxia induced activation of SHH pathway has modulatory effects on CC progression.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	103-106
31016387-7	2019	Here we consolidated our previous finding that taurine stimulated SGN density and the proliferation index, which were completely abolished by Shh inhibitor, cyclopamine.	cyclopamine	157-168	sonic hedgehog	Mus musculus	142-145
31702025-8	2019	Small-interfering RNA (siRNA) for glioma-associated antigen-1 (Gli1) or cyclopamine was used to inhibit SHH signaling in HBECs.	cyclopamine	72-83	sonic hedgehog signaling molecule	Homo sapiens	104-107
31016387-9	2019	In addition, cyclopamine antagonized taurine"s effect on glutamatergic and GABAergic neuron population via suppression of VGLUT1 and GAT1 expression.	cyclopamine	13-24	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	Mus musculus	122-128
31016387-9	2019	In addition, cyclopamine antagonized taurine"s effect on glutamatergic and GABAergic neuron population via suppression of VGLUT1 and GAT1 expression.	cyclopamine	13-24	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	133-137
31016387-10	2019	Mechanistically, taurine evidently activated the Sonic HedgeHog pathway and upregulated Shh, Ptc-1, Smo and Gli-1 proteins, which were specifically blockaded by cyclopamine.	cyclopamine	161-172	sonic hedgehog	Mus musculus	88-91
31016387-10	2019	Mechanistically, taurine evidently activated the Sonic HedgeHog pathway and upregulated Shh, Ptc-1, Smo and Gli-1 proteins, which were specifically blockaded by cyclopamine.	cyclopamine	161-172	patched 1	Mus musculus	93-98
31016387-10	2019	Mechanistically, taurine evidently activated the Sonic HedgeHog pathway and upregulated Shh, Ptc-1, Smo and Gli-1 proteins, which were specifically blockaded by cyclopamine.	cyclopamine	161-172	smoothened, frizzled class receptor	Mus musculus	100-103
31016387-10	2019	Mechanistically, taurine evidently activated the Sonic HedgeHog pathway and upregulated Shh, Ptc-1, Smo and Gli-1 proteins, which were specifically blockaded by cyclopamine.	cyclopamine	161-172	GLI-Kruppel family member GLI1	Mus musculus	108-113
30548093-7	2019	Meanwhile, cyclopamine, a specific Shh pathway inhibitor, was intraperitoneally injected at 1 and 21 hours after stroke.	cyclopamine	11-22	sonic hedgehog	Mus musculus	35-38
31326407-14	2019	Suppression of SHH pathway by cyclopamine attenuated the protective effects of hyperoside on H2O2-induced injury.	cyclopamine	30-41	sonic hedgehog signaling molecule	Rattus norvegicus	15-18
31367836-10	2019	Significant cyclopamine-induced suppression of Gli1 in 5637 and T24 mouse tumors (both p = 0.03) was seen, suggesting that muscle-invasive bladder cancer may be more dependent on Shh signaling than non-muscle-invasive bladder cancer.	cyclopamine	12-23	GLI-Kruppel family member GLI1	Mus musculus	47-51
31367836-10	2019	Significant cyclopamine-induced suppression of Gli1 in 5637 and T24 mouse tumors (both p = 0.03) was seen, suggesting that muscle-invasive bladder cancer may be more dependent on Shh signaling than non-muscle-invasive bladder cancer.	cyclopamine	12-23	sonic hedgehog	Mus musculus	179-182
30638689-8	2019	Furthermore, after treating with Smo inhibitor cyclopamine, the Smo and Gli1 expressions in BMSCs are dramatically down-regulation for the BGC coating compared to those for the control group.	cyclopamine	47-58	smoothened, frizzled class receptor	Homo sapiens	33-36
30638689-8	2019	Furthermore, after treating with Smo inhibitor cyclopamine, the Smo and Gli1 expressions in BMSCs are dramatically down-regulation for the BGC coating compared to those for the control group.	cyclopamine	47-58	smoothened, frizzled class receptor	Homo sapiens	64-67
30638689-8	2019	Furthermore, after treating with Smo inhibitor cyclopamine, the Smo and Gli1 expressions in BMSCs are dramatically down-regulation for the BGC coating compared to those for the control group.	cyclopamine	47-58	GLI family zinc finger 1	Homo sapiens	72-76
30638689-9	2019	Both mRNA and protein expression levels of osteogenesis-related factors was downregulated after treating Smo inhibitor cyclopamine in BMSCs with the BGC coating.	cyclopamine	119-130	smoothened, frizzled class receptor	Homo sapiens	105-108
31297044-10	2019	By contrast, the expression levels of TGF-beta2 and p-Smad3 did not change significantly after pre-injection of Smo inhibitor cyclopamine, but reduced the expression levels of Shh, Ptch, and Gli1.	cyclopamine	126-137	transforming growth factor, beta 2	Rattus norvegicus	38-47
31297044-10	2019	By contrast, the expression levels of TGF-beta2 and p-Smad3 did not change significantly after pre-injection of Smo inhibitor cyclopamine, but reduced the expression levels of Shh, Ptch, and Gli1.	cyclopamine	126-137	SMAD family member 3	Rattus norvegicus	54-59
30548093-10	2019	Meanwhile, cyclopamine blocked the effect of TXL-up-regulated expression of occludin, claudin-5 and ZO-1.	cyclopamine	11-22	occludin	Mus musculus	76-84
30548093-10	2019	Meanwhile, cyclopamine blocked the effect of TXL-up-regulated expression of occludin, claudin-5 and ZO-1.	cyclopamine	11-22	claudin 5	Mus musculus	86-95
30548093-10	2019	Meanwhile, cyclopamine blocked the effect of TXL-up-regulated expression of occludin, claudin-5 and ZO-1.	cyclopamine	11-22	tight junction protein 1	Mus musculus	100-104
30548093-12	2019	And cyclopamine inhibited TXL-induced activation of the Shh pathway.	cyclopamine	4-15	sonic hedgehog	Mus musculus	56-59
31120491-8	2019	Finally, the influence of SHH signalling on foetal growth was examined by placental administration of cyclopamine, an SHH pathway inhibitor, to pregnant mice.	cyclopamine	102-113	sonic hedgehog	Mus musculus	118-121
30865837-8	2019	Accordingly, inhibition of SMO by cyclopamine reversed miR-370i-induced HDMEC proliferation and migration.	cyclopamine	34-45	smoothened, frizzled class receptor	Mus musculus	27-30
31258739-0	2019	Co-delivery of Cyclopamine and Doxorubicin Mediated by Bovine Serum Albumin Nanoparticles Reverses Doxorubicin Resistance in Breast Cancer by Down-regulating P-glycoprotein Expression.	cyclopamine	15-26	ATP binding cassette subfamily B member 1	Homo sapiens	99-121
31258739-0	2019	Co-delivery of Cyclopamine and Doxorubicin Mediated by Bovine Serum Albumin Nanoparticles Reverses Doxorubicin Resistance in Breast Cancer by Down-regulating P-glycoprotein Expression.	cyclopamine	15-26	ATP binding cassette subfamily B member 1	Homo sapiens	158-172
30784288-8	2019	Cyclopamine, a Shh signaling pathway inhibitor, reduced the effects of LKB1 silence, indicating that LKB1 inhibits the migration, invasion and angiogenesis through suppressing the Shh signaling pathway.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	15-18
30784288-8	2019	Cyclopamine, a Shh signaling pathway inhibitor, reduced the effects of LKB1 silence, indicating that LKB1 inhibits the migration, invasion and angiogenesis through suppressing the Shh signaling pathway.	cyclopamine	0-11	serine/threonine kinase 11	Homo sapiens	71-75
30784288-8	2019	Cyclopamine, a Shh signaling pathway inhibitor, reduced the effects of LKB1 silence, indicating that LKB1 inhibits the migration, invasion and angiogenesis through suppressing the Shh signaling pathway.	cyclopamine	0-11	serine/threonine kinase 11	Homo sapiens	101-105
30784288-8	2019	Cyclopamine, a Shh signaling pathway inhibitor, reduced the effects of LKB1 silence, indicating that LKB1 inhibits the migration, invasion and angiogenesis through suppressing the Shh signaling pathway.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	180-183
31190842-10	2019	Those changes were inhibited by the Shh-pathway inhibitor cyclopamine.	cyclopamine	58-69	sonic hedgehog signaling molecule	Rattus norvegicus	36-39
30582981-10	2019	Additionally, the Smo inhibitor cyclopamine was shown to impair the self-renewal of liver CSCs and suppress tumor propagation.	cyclopamine	32-43	smoothened, frizzled class receptor	Homo sapiens	18-21
31018557-5	2019	Purmorphamine treatment significantly increased NSC proliferation and clonal expansion via GLI-Kruppel family member 1 (Gli1) nuclear translocation and such effects were prevented by cyclopamine co-treatment.	cyclopamine	183-194	GLI family zinc finger 1	Homo sapiens	91-118
31018557-5	2019	Purmorphamine treatment significantly increased NSC proliferation and clonal expansion via GLI-Kruppel family member 1 (Gli1) nuclear translocation and such effects were prevented by cyclopamine co-treatment.	cyclopamine	183-194	GLI family zinc finger 1	Homo sapiens	120-124
31018557-7	2019	Moreover, cellular thermal shift assay suggested that clobetasol induces the canonical Smo-dependent activation of Shh signaling, as confirmed by Gli1 nuclear translocation and also by cyclopamine co-treatment, which abolished these effects.	cyclopamine	185-196	smoothened, frizzled class receptor	Homo sapiens	87-90
31018557-7	2019	Moreover, cellular thermal shift assay suggested that clobetasol induces the canonical Smo-dependent activation of Shh signaling, as confirmed by Gli1 nuclear translocation and also by cyclopamine co-treatment, which abolished these effects.	cyclopamine	185-196	sonic hedgehog signaling molecule	Homo sapiens	115-118
31024240-10	2019	However, cyclopamine, the specific inhibitor of the Sonic hedgehog (Shh) signaling pathway, decreased the expression levels of VEGF and CD34, and counteracted the protective effects of ISO post-conditioning against I/R injury in rats.	cyclopamine	9-20	sonic hedgehog signaling molecule	Rattus norvegicus	52-66
31024240-10	2019	However, cyclopamine, the specific inhibitor of the Sonic hedgehog (Shh) signaling pathway, decreased the expression levels of VEGF and CD34, and counteracted the protective effects of ISO post-conditioning against I/R injury in rats.	cyclopamine	9-20	sonic hedgehog signaling molecule	Rattus norvegicus	68-71
31024240-10	2019	However, cyclopamine, the specific inhibitor of the Sonic hedgehog (Shh) signaling pathway, decreased the expression levels of VEGF and CD34, and counteracted the protective effects of ISO post-conditioning against I/R injury in rats.	cyclopamine	9-20	vascular endothelial growth factor A	Rattus norvegicus	127-131
31024240-10	2019	However, cyclopamine, the specific inhibitor of the Sonic hedgehog (Shh) signaling pathway, decreased the expression levels of VEGF and CD34, and counteracted the protective effects of ISO post-conditioning against I/R injury in rats.	cyclopamine	9-20	CD34 molecule	Rattus norvegicus	136-140
30497008-3	2019	Functional experiments were performed by previously treating (2 h) semiconfluent osteoblast cultures with cyclopamine molecule (cyc), a widely used Shh inhibitor.	cyclopamine	106-117	sonic hedgehog signaling molecule	Homo sapiens	148-151
30367510-11	2019	Further analysis showed that using cyclopamine to inhibit Shh signaling significantly ameliorated the effect on cell proliferation, invasion, and migration, as well as EMT triggered by PEBP4 overexpression.	cyclopamine	35-46	sonic hedgehog signaling molecule	Homo sapiens	58-61
30367510-11	2019	Further analysis showed that using cyclopamine to inhibit Shh signaling significantly ameliorated the effect on cell proliferation, invasion, and migration, as well as EMT triggered by PEBP4 overexpression.	cyclopamine	35-46	phosphatidylethanolamine binding protein 4	Homo sapiens	185-190
30644322-6	2019	Moreover, the SMO inhibitor cyclopamine enhances the cytotoxic effects of bortezomib in MM cell lines.	cyclopamine	28-39	smoothened, frizzled class receptor	Homo sapiens	14-17
30807555-0	2019	Cyclopamine Suppresses Human Esophageal Carcinoma Cell Growth by Inhibiting Glioma-Associated Oncogene Protein-1, a Marker of Human Esophageal Carcinoma Progression.	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	76-112
30807555-13	2019	Gli-1 was obviously reduced after cyclopamine treatment and the effect was dose-dependent.	cyclopamine	34-45	GLI family zinc finger 1	Homo sapiens	0-5
30714153-7	2019	Further, we evaluated the role of two inhibitors (cyclopamine and GANT58) of the Hh pathway on invasiveness and apoptosis in E-cadherin low cervical cancer cells.	cyclopamine	50-61	cadherin 1	Homo sapiens	125-135
30712259-12	2019	After blocking the Shh signaling pathway with a specific inhibitor, cyclopamine, the cardioprotective functions of MEKK3 downregulation were partly abolished.	cyclopamine	68-79	sonic hedgehog signaling molecule	Rattus norvegicus	19-22
30535481-7	2019	The combination of astragaloside IV and cyclopamine reduced MG-63 and U-2OS cell proliferation and migration, and inhibited the gene expression of SHH and GLI1.	cyclopamine	40-51	sonic hedgehog signaling molecule	Homo sapiens	147-150
30535481-7	2019	The combination of astragaloside IV and cyclopamine reduced MG-63 and U-2OS cell proliferation and migration, and inhibited the gene expression of SHH and GLI1.	cyclopamine	40-51	GLI family zinc finger 1	Homo sapiens	155-159
29215733-7	2018	At the same time, a significant increase in the expression levels of mRNAs related to cumulus expansion, oocyte maturation and SHH signaling-related mRNAs and proteins from the resveratrol treatment group was also inhibited by simultaneous addition of cyclopamine.	cyclopamine	252-263	sonic hedgehog signaling molecule	Sus scrofa	127-130
30036521-7	2018	The treatment of PCK cholangiocytes with cyclopamine inhibited cell proliferative activity that was associated with the inhibition of nuclear translocation of Gli1 and Gli2, and reduced cyclin D1 expression.	cyclopamine	41-52	GLI family zinc finger 1	Rattus norvegicus	159-163
30036521-7	2018	The treatment of PCK cholangiocytes with cyclopamine inhibited cell proliferative activity that was associated with the inhibition of nuclear translocation of Gli1 and Gli2, and reduced cyclin D1 expression.	cyclopamine	41-52	GLI family zinc finger 2	Rattus norvegicus	168-172
30036521-7	2018	The treatment of PCK cholangiocytes with cyclopamine inhibited cell proliferative activity that was associated with the inhibition of nuclear translocation of Gli1 and Gli2, and reduced cyclin D1 expression.	cyclopamine	41-52	cyclin D1	Rattus norvegicus	186-195
29573522-10	2018	Treatment with cyclopamine, a Shh signaling pathway inhibitor, reversed the effects of LKB1 silencing and enhanced the effects of LKB1 over-expression.	cyclopamine	15-26	sonic hedgehog signaling molecule	Homo sapiens	30-33
29573522-10	2018	Treatment with cyclopamine, a Shh signaling pathway inhibitor, reversed the effects of LKB1 silencing and enhanced the effects of LKB1 over-expression.	cyclopamine	15-26	serine/threonine kinase 11	Homo sapiens	87-91
29573522-10	2018	Treatment with cyclopamine, a Shh signaling pathway inhibitor, reversed the effects of LKB1 silencing and enhanced the effects of LKB1 over-expression.	cyclopamine	15-26	serine/threonine kinase 11	Homo sapiens	130-134
30568656-4	2018	SHH signaling was studied by using SHH agonist (Purmorphamine) and antagonist (Cyclopamine) targeting the Smoothened (SMO) in FLSs.	cyclopamine	79-90	sonic hedgehog signaling molecule	Homo sapiens	0-3
30568656-4	2018	SHH signaling was studied by using SHH agonist (Purmorphamine) and antagonist (Cyclopamine) targeting the Smoothened (SMO) in FLSs.	cyclopamine	79-90	smoothened, frizzled class receptor	Homo sapiens	106-116
30568656-10	2018	Co-treated with Purmorphamine and U0126-EtOH or Cyclopamine both decreased the levels of p-ERK1/2 (P < 0.05).	cyclopamine	48-59	mitogen-activated protein kinase 3	Homo sapiens	91-97
30272371-12	2018	SHH acts as a potent promoter of the expression of Gremlin 1, and cyclopamine and Gli-1 siRNA modulated this effect.	cyclopamine	66-77	sonic hedgehog signaling molecule	Homo sapiens	0-3
30218952-13	2018	Blockade of the Shh pathway using cyclopamine abolished the effects of polydatin on mice with colitis.	cyclopamine	34-45	sonic hedgehog	Mus musculus	16-19
28849750-2	2018	Different SMO inhibitors/drugs (e.g. Cyclopamine, Vismodegib, Taladegib) used till date are found to be associated with several drug-related resistivity and toxicity.	cyclopamine	37-48	smoothened, frizzled class receptor	Homo sapiens	10-13
29132010-4	2018	SNK-6 cells were transfected with FOXQ1-shRNA or Shh pathway inhibitor Cyclopamine/recombinant protein Shh.	cyclopamine	71-82	sonic hedgehog signaling molecule	Homo sapiens	49-52
29861625-11	2018	The mRNA and protein expressions of Smoothened, Gli1, and vascular endothelial growth factor in the signal pathway of the OIR and OIR-control groups were significantly higher than those of the control group; however, in the cyclopamine group, these factors were reduced when compared with the OIR and OIR-control groups (all P<0.05).	cyclopamine	224-235	smoothened, frizzled class receptor	Mus musculus	36-46
29861625-11	2018	The mRNA and protein expressions of Smoothened, Gli1, and vascular endothelial growth factor in the signal pathway of the OIR and OIR-control groups were significantly higher than those of the control group; however, in the cyclopamine group, these factors were reduced when compared with the OIR and OIR-control groups (all P<0.05).	cyclopamine	224-235	GLI-Kruppel family member GLI1	Mus musculus	48-52
29861625-13	2018	Inhibiting the Smoothened receptor using cyclopamine could control retinal neovascularization, providing new ideas and measures for the prevention of oxygen-induced retinal neovascularization.	cyclopamine	41-52	smoothened, frizzled class receptor	Mus musculus	15-25
29731823-11	2018	However, the EGCG-mediated neuroprotective effects, as well as upregulation of the Shh pathway were all attenuated by the Shh signaling inhibitor cyclopamine.	cyclopamine	146-157	sonic hedgehog signaling molecule	Rattus norvegicus	83-86
29731823-11	2018	However, the EGCG-mediated neuroprotective effects, as well as upregulation of the Shh pathway were all attenuated by the Shh signaling inhibitor cyclopamine.	cyclopamine	146-157	sonic hedgehog signaling molecule	Rattus norvegicus	122-125
29189160-5	2018	GLI inhibitors such as zerumbone, GANT61, resveratrol, and cyclopamine depress the Hh pathway in vitro and in vivo cancer research, and other non-canonical pathways may also activate expression of GLI1.	cyclopamine	59-70	GLI family zinc finger 1	Homo sapiens	197-201
29128669-10	2018	Additionally, activating or inhibiting the SHH pathway by purmorphamine or cyclopamine, respectively, abolished the Wip1-induced changes in transepithelial electrical resistance and permeability and inflammatory responses in the LPS-injured BBB model.	cyclopamine	75-86	sonic hedgehog signaling molecule	Homo sapiens	43-46
29128669-10	2018	Additionally, activating or inhibiting the SHH pathway by purmorphamine or cyclopamine, respectively, abolished the Wip1-induced changes in transepithelial electrical resistance and permeability and inflammatory responses in the LPS-injured BBB model.	cyclopamine	75-86	protein phosphatase, Mg2+/Mn2+ dependent 1D	Homo sapiens	116-120
29225516-9	2017	Inhibition of the HH/Gli1 signaling by cyclopamine in U251 cells resulted in decreased MGMT expression and increased sensitivity to TMZ treatment.	cyclopamine	39-50	GLI family zinc finger 1	Homo sapiens	21-25
29225516-9	2017	Inhibition of the HH/Gli1 signaling by cyclopamine in U251 cells resulted in decreased MGMT expression and increased sensitivity to TMZ treatment.	cyclopamine	39-50	O-6-methylguanine-DNA methyltransferase	Homo sapiens	87-91
29849100-6	2018	Furthermore, our experiments show that cyclopamine acts late downregulating GLI1 expression in ADSCs but promotes the upregulation of mRNAs associated with energy pathways and metabolism at early times.	cyclopamine	39-50	GLI family zinc finger 1	Homo sapiens	76-80
29618829-7	2018	In the presence of HLA-G inducers (interferon-beta and progesterone) or repressors (cyclopamine) HLA-G promoter activity was modulated, but certain haplotypes exhibited differential responses.	cyclopamine	84-95	major histocompatibility complex, class I, G	Homo sapiens	97-102
29428403-8	2018	Inhibition of Shh signaling by cyclopamine application at the transection site led to abnormal axon growth in random directions, a reduced number of macrophages, and an increase in myelin debris within the distal region.	cyclopamine	31-42	sonic hedgehog	Mus musculus	14-17
29329377-6	2018	Transfection with overactive Gli2 plasmids induced higher fibrosis-related protein expression, while blocking Gli2 signaling with cyclopamine caused the opposite effect in endometriotic stromal cells (ESCs), including inducing cell-cycle arrest.	cyclopamine	130-141	GLI family zinc finger 2	Homo sapiens	110-114
29305935-9	2018	Hedgehog and YAP activity were inhibited by incubation of cells with cyclopamine or verteporfin, and effects on glutaminolysis were measured.	cyclopamine	69-80	Yes1 associated transcriptional regulator	Homo sapiens	13-16
29541219-6	2018	Compared with control group values, Gli-1, Twist1 and N-cadherin expression levels were reduced, whereas E-cadherin levels were increased in the casticin- and cyclopamine-treated groups.	cyclopamine	159-170	cadherin 2	Homo sapiens	54-64
29541219-6	2018	Compared with control group values, Gli-1, Twist1 and N-cadherin expression levels were reduced, whereas E-cadherin levels were increased in the casticin- and cyclopamine-treated groups.	cyclopamine	159-170	cadherin 1	Homo sapiens	105-115
29137952-3	2018	In this study, it was further revealed that the pro-chondrogenic activities of Nell-1 also rely on Ihh signaling, by showing: i) Nell-1 significantly elevated Ihh signal transduction; ii) Nell-1 deficiency markedly reduced Ihh activation in chondrocytes; and iii) Nell-1-stimulated chondrogenesis was significantly reduced by the specific hedgehog inhibitor cyclopamine.	cyclopamine	358-369	neural EGFL like 1	Homo sapiens	79-85
30355933-15	2018	RESULTS: Resveratrol, Sirt1 agonist STR1720 and recombinant mouse Shh protein, an activator of hedgehog signaling, enhanced the viability of NIH3T3 cells, promoted Smo to translocated to the primary cilia and Gli-1 entered into the nuclei from cytoplasm, and upregulated expressions of Shh, Ptc-1, Smo, and Gli-1 proteins, which can be reversed by Smo antagonist cyclopamine and Sirt1 antagonist Sirtinol.	cyclopamine	363-374	sirtuin 1	Mus musculus	22-27
30355933-15	2018	RESULTS: Resveratrol, Sirt1 agonist STR1720 and recombinant mouse Shh protein, an activator of hedgehog signaling, enhanced the viability of NIH3T3 cells, promoted Smo to translocated to the primary cilia and Gli-1 entered into the nuclei from cytoplasm, and upregulated expressions of Shh, Ptc-1, Smo, and Gli-1 proteins, which can be reversed by Smo antagonist cyclopamine and Sirt1 antagonist Sirtinol.	cyclopamine	363-374	sonic hedgehog	Mus musculus	66-69
30355933-15	2018	RESULTS: Resveratrol, Sirt1 agonist STR1720 and recombinant mouse Shh protein, an activator of hedgehog signaling, enhanced the viability of NIH3T3 cells, promoted Smo to translocated to the primary cilia and Gli-1 entered into the nuclei from cytoplasm, and upregulated expressions of Shh, Ptc-1, Smo, and Gli-1 proteins, which can be reversed by Smo antagonist cyclopamine and Sirt1 antagonist Sirtinol.	cyclopamine	363-374	smoothened, frizzled class receptor	Mus musculus	164-167
29030175-8	2018	Conversely, inhibition of Shh signaling using intraocular injections of cyclopamine resulted in decreased Muller glial cell proliferation and a fewer number of regenerated amacrine and ganglion cells.	cyclopamine	72-83	sonic hedgehog signaling molecule a	Danio rerio	26-29
29607715-6	2018	Inhibiting sonic hedgehog signaling activation with cyclopamine, in vivo or in vitro, greatly suppresses tumor cell implantation-induced increase of intracellular Ca2+ and hyperexcitability of the sensory neurons and also the activation of GluN2B receptor and the subsequent Ca2+-dependent signals CaMKII and CREB in dorsal root ganglion and the spinal cord.	cyclopamine	52-63	cAMP responsive element binding protein 1	Rattus norvegicus	309-313
29115520-6	2018	Cyclopamine, a smoothened (SMO) antagonist, was used to inhibit SMO activity.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	27-30
29115520-6	2018	Cyclopamine, a smoothened (SMO) antagonist, was used to inhibit SMO activity.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	64-67
29115520-12	2018	Furthermore, pretreatment with cyclopamine or predepletion of Gli-1 by siRNA also eliminated the changes of Snail, vimentin and E-cadherin, and HCC invasion and EMT caused by CCL2.	cyclopamine	31-42	snail family transcriptional repressor 1	Homo sapiens	108-113
29115520-12	2018	Furthermore, pretreatment with cyclopamine or predepletion of Gli-1 by siRNA also eliminated the changes of Snail, vimentin and E-cadherin, and HCC invasion and EMT caused by CCL2.	cyclopamine	31-42	vimentin	Homo sapiens	115-123
29115520-12	2018	Furthermore, pretreatment with cyclopamine or predepletion of Gli-1 by siRNA also eliminated the changes of Snail, vimentin and E-cadherin, and HCC invasion and EMT caused by CCL2.	cyclopamine	31-42	cadherin 1	Homo sapiens	128-138
29115520-12	2018	Furthermore, pretreatment with cyclopamine or predepletion of Gli-1 by siRNA also eliminated the changes of Snail, vimentin and E-cadherin, and HCC invasion and EMT caused by CCL2.	cyclopamine	31-42	C-C motif chemokine ligand 2	Homo sapiens	175-179
30102120-7	2018	Here we presented our findings that taurine stimulated proliferation and neurite outgrowth of NSCs, which was completely abolished by Shh inhibitor cyclopamine.	cyclopamine	148-159	sonic hedgehog	Mus musculus	134-137
30102120-8	2018	In addition, cyclopamine antagonized taurine"s effect on glutamatergic and GABAergic neuron population via suppressing expressions of Ptc-1, Smo and Gli-1.	cyclopamine	13-24	patched 1	Mus musculus	134-139
30102120-8	2018	In addition, cyclopamine antagonized taurine"s effect on glutamatergic and GABAergic neuron population via suppressing expressions of Ptc-1, Smo and Gli-1.	cyclopamine	13-24	smoothened, frizzled class receptor	Mus musculus	141-144
30102120-8	2018	In addition, cyclopamine antagonized taurine"s effect on glutamatergic and GABAergic neuron population via suppressing expressions of Ptc-1, Smo and Gli-1.	cyclopamine	13-24	GLI-Kruppel family member GLI1	Mus musculus	149-154
29039491-9	2017	Primary cells developed from ovarian carcinoma tissue respond to cyclopamine treatment with a short-term decrease in cell proliferation, downregulation of Hedgehog pathway genes, including BIRC5, and changes in protein dynamics.	cyclopamine	65-76	baculoviral IAP repeat containing 5	Homo sapiens	189-194
29119099-7	2017	The expected increase in Wnt/beta-catenin-dependent TCF-LEF reporter activity and PrE markers induced by RA was, however, blocked by cyclopamine.	cyclopamine	133-144	catenin (cadherin associated protein), beta 1	Mus musculus	29-41
28921619-8	2017	Intraperitoneal injection of ligated Sca1-eGFP mice with the SHh signaling inhibitor cyclopamine diminished SHh target gene expression, reduced the number of Sca1+ cells, and ameliorated carotid remodeling.	cyclopamine	85-96	lymphocyte antigen 6 complex, locus A	Mus musculus	37-41
28921619-8	2017	Intraperitoneal injection of ligated Sca1-eGFP mice with the SHh signaling inhibitor cyclopamine diminished SHh target gene expression, reduced the number of Sca1+ cells, and ameliorated carotid remodeling.	cyclopamine	85-96	sonic hedgehog	Mus musculus	61-64
28921619-8	2017	Intraperitoneal injection of ligated Sca1-eGFP mice with the SHh signaling inhibitor cyclopamine diminished SHh target gene expression, reduced the number of Sca1+ cells, and ameliorated carotid remodeling.	cyclopamine	85-96	sonic hedgehog	Mus musculus	108-111
28921619-8	2017	Intraperitoneal injection of ligated Sca1-eGFP mice with the SHh signaling inhibitor cyclopamine diminished SHh target gene expression, reduced the number of Sca1+ cells, and ameliorated carotid remodeling.	cyclopamine	85-96	lymphocyte antigen 6 complex, locus A	Mus musculus	158-162
28887094-6	2017	Sonic hedgehog (Shh) inhibitor cyclopamine (CYC) was injected to determine the involvement of Shh pathway in the therapeutic effects of SAFI.	cyclopamine	31-42	sonic hedgehog	Mus musculus	0-14
28887094-9	2017	Simultaneous administration with CYC strikingly attenuated the beneficial outcomes of SAFI as well as abolished SAFI induced BDNF and NGF production.	cyclopamine	33-36	brain derived neurotrophic factor	Mus musculus	125-129
29187450-4	2017	We also evaluated the function of SHH signaling using the hedgehog signaling inhibitor cyclopamine in vivo and in vitro by proliferation, migration and angiogenesis analyses.	cyclopamine	87-98	sonic hedgehog signaling molecule	Homo sapiens	34-37
28840059-4	2017	Additionally, injection of Shh into MHE/DA-treated rats reversed downregulation of BDNF/NT3, whereas administration of cyclopamine (Cyc) enhanced the inhibition of expression of BDNF/NT3.	cyclopamine	119-130	brain-derived neurotrophic factor	Rattus norvegicus	178-182
28779609-4	2017	Our results showed that supplementation of Shh (0.25 or 0.5 mug mL-1) enhanced oocyte maturation as compared with the control group (92.4% and 95.0% vs. 86.2%, P < 0.05), yet the effect could be reversed by the simultaneous addition of cyclopamine (an inhibitor of Shh signaling by direct binding to the essential signal transducer Smo).	cyclopamine	239-250	LOW QUALITY PROTEIN: sonic hedgehog protein	Capra hircus	43-46
29137400-8	2017	Moreover, we show via cyclopamine inhibition of the SHH/GLI pathway of ex vivo cultures that NEO1 likely functions as a downstream target of SHH/GLI signaling in the skin.	cyclopamine	22-33	sonic hedgehog signaling molecule	Homo sapiens	52-55
29137400-8	2017	Moreover, we show via cyclopamine inhibition of the SHH/GLI pathway of ex vivo cultures that NEO1 likely functions as a downstream target of SHH/GLI signaling in the skin.	cyclopamine	22-33	GLI family zinc finger 1	Homo sapiens	56-59
29137400-8	2017	Moreover, we show via cyclopamine inhibition of the SHH/GLI pathway of ex vivo cultures that NEO1 likely functions as a downstream target of SHH/GLI signaling in the skin.	cyclopamine	22-33	neogenin 1	Homo sapiens	93-97
29137400-8	2017	Moreover, we show via cyclopamine inhibition of the SHH/GLI pathway of ex vivo cultures that NEO1 likely functions as a downstream target of SHH/GLI signaling in the skin.	cyclopamine	22-33	sonic hedgehog signaling molecule	Homo sapiens	141-144
29137400-8	2017	Moreover, we show via cyclopamine inhibition of the SHH/GLI pathway of ex vivo cultures that NEO1 likely functions as a downstream target of SHH/GLI signaling in the skin.	cyclopamine	22-33	GLI family zinc finger 1	Homo sapiens	145-148
28667508-10	2017	After adding the hedgehog signaling inhibitor CY (cyclopamine), cell proliferation and Ihh, Ptch, Smo, and Gli expressions were inhibited (p = 0.00), and the cell amount at S phase was reduced compared with combination groups (p = 0.00).	cyclopamine	46-48	Indian hedgehog	Mus musculus	87-90
28667508-10	2017	After adding the hedgehog signaling inhibitor CY (cyclopamine), cell proliferation and Ihh, Ptch, Smo, and Gli expressions were inhibited (p = 0.00), and the cell amount at S phase was reduced compared with combination groups (p = 0.00).	cyclopamine	46-48	patched 1	Mus musculus	92-96
28667508-10	2017	After adding the hedgehog signaling inhibitor CY (cyclopamine), cell proliferation and Ihh, Ptch, Smo, and Gli expressions were inhibited (p = 0.00), and the cell amount at S phase was reduced compared with combination groups (p = 0.00).	cyclopamine	46-48	smoothened, frizzled class receptor	Mus musculus	98-101
28667508-10	2017	After adding the hedgehog signaling inhibitor CY (cyclopamine), cell proliferation and Ihh, Ptch, Smo, and Gli expressions were inhibited (p = 0.00), and the cell amount at S phase was reduced compared with combination groups (p = 0.00).	cyclopamine	50-61	Indian hedgehog	Mus musculus	87-90
28667508-10	2017	After adding the hedgehog signaling inhibitor CY (cyclopamine), cell proliferation and Ihh, Ptch, Smo, and Gli expressions were inhibited (p = 0.00), and the cell amount at S phase was reduced compared with combination groups (p = 0.00).	cyclopamine	50-61	patched 1	Mus musculus	92-96
28667508-10	2017	After adding the hedgehog signaling inhibitor CY (cyclopamine), cell proliferation and Ihh, Ptch, Smo, and Gli expressions were inhibited (p = 0.00), and the cell amount at S phase was reduced compared with combination groups (p = 0.00).	cyclopamine	50-61	smoothened, frizzled class receptor	Mus musculus	98-101
28624529-0	2017	Cyclopamine sensitizes TRAIL-resistant gastric cancer cells to TRAIL-induced apoptosis via endoplasmic reticulum stress-mediated increase of death receptor 5 and survivin degradation.	cyclopamine	0-11	TNF superfamily member 10	Homo sapiens	23-28
28624529-0	2017	Cyclopamine sensitizes TRAIL-resistant gastric cancer cells to TRAIL-induced apoptosis via endoplasmic reticulum stress-mediated increase of death receptor 5 and survivin degradation.	cyclopamine	0-11	TNF superfamily member 10	Homo sapiens	63-68
28624529-0	2017	Cyclopamine sensitizes TRAIL-resistant gastric cancer cells to TRAIL-induced apoptosis via endoplasmic reticulum stress-mediated increase of death receptor 5 and survivin degradation.	cyclopamine	0-11	TNF receptor superfamily member 10b	Homo sapiens	141-157
28624529-3	2017	In this study, we show that cyclopamine sensitizes gastric cancer cells to TRAIL-induced apoptosis by elevating the expression of DR5.	cyclopamine	28-39	TNF superfamily member 10	Homo sapiens	75-80
28624529-3	2017	In this study, we show that cyclopamine sensitizes gastric cancer cells to TRAIL-induced apoptosis by elevating the expression of DR5.	cyclopamine	28-39	TNF receptor superfamily member 10b	Homo sapiens	130-133
28624529-4	2017	Interestingly, survivin hampers the existence of DR5 protein under normal conditions and cyclopamine decreases the expression of survivin, thus acting as a TRAIL sensitizer.	cyclopamine	89-100	TNF superfamily member 10	Homo sapiens	156-161
28624529-5	2017	Mechanistically, cyclopamine induces endoplasmic reticulum (ER) stress via reactive oxygen species (ROS) and CHOP, the last protein of the ER stress pathway and it regulates the proteasome degradation of survivin.	cyclopamine	17-28	DNA damage inducible transcript 3	Homo sapiens	109-113
28624529-6	2017	Taken together, our results indicate that cyclopamine can be used for combination therapy in TRAIL-resistant gastric cancer cells.	cyclopamine	42-53	TNF superfamily member 10	Homo sapiens	93-98
28840059-4	2017	Additionally, injection of Shh into MHE/DA-treated rats reversed downregulation of BDNF/NT3, whereas administration of cyclopamine (Cyc) enhanced the inhibition of expression of BDNF/NT3.	cyclopamine	119-130	neurotrophin 3	Rattus norvegicus	183-186
28840059-4	2017	Additionally, injection of Shh into MHE/DA-treated rats reversed downregulation of BDNF/NT3, whereas administration of cyclopamine (Cyc) enhanced the inhibition of expression of BDNF/NT3.	cyclopamine	132-135	brain-derived neurotrophic factor	Rattus norvegicus	178-182
28840059-4	2017	Additionally, injection of Shh into MHE/DA-treated rats reversed downregulation of BDNF/NT3, whereas administration of cyclopamine (Cyc) enhanced the inhibition of expression of BDNF/NT3.	cyclopamine	132-135	neurotrophin 3	Rattus norvegicus	183-186
28477008-0	2017	Combination therapy with micellarized cyclopamine and temozolomide attenuate glioblastoma growth through Gli1 down-regulation.	cyclopamine	38-49	GLI family zinc finger 1	Homo sapiens	105-109
28477008-2	2017	We studied the efficacy and related mechanisms of the combination of cyclopamine (Cyp, a Sonic-hedgehog pathway (Shh) inhibitor) and temozolomide (TMZ, the clinically most used chemotherapeutic agent) in anti-GBM treatment.	cyclopamine	69-80	peptidylprolyl isomerase G	Homo sapiens	82-85
28607372-3	2017	In this study, we established a robust hPSC-derived cortical neurogenesis system by applying the SHH inhibitor cyclopamine.	cyclopamine	111-122	sonic hedgehog signaling molecule	Homo sapiens	97-100
28607372-4	2017	Cyclopamine specified the dorsal cortical fate in a dose-dependent manner and enhanced the generation of cortical glutamatergic neurons, expressing PAX6, TBR1, TBR2, CTIP2, SATB2, and vesicular glutamate transporters (vGLUT).	cyclopamine	0-11	paired box 6	Homo sapiens	148-152
28607372-4	2017	Cyclopamine specified the dorsal cortical fate in a dose-dependent manner and enhanced the generation of cortical glutamatergic neurons, expressing PAX6, TBR1, TBR2, CTIP2, SATB2, and vesicular glutamate transporters (vGLUT).	cyclopamine	0-11	T-box brain transcription factor 1	Homo sapiens	154-158
28607372-4	2017	Cyclopamine specified the dorsal cortical fate in a dose-dependent manner and enhanced the generation of cortical glutamatergic neurons, expressing PAX6, TBR1, TBR2, CTIP2, SATB2, and vesicular glutamate transporters (vGLUT).	cyclopamine	0-11	eomesodermin	Homo sapiens	160-164
28607372-4	2017	Cyclopamine specified the dorsal cortical fate in a dose-dependent manner and enhanced the generation of cortical glutamatergic neurons, expressing PAX6, TBR1, TBR2, CTIP2, SATB2, and vesicular glutamate transporters (vGLUT).	cyclopamine	0-11	BAF chromatin remodeling complex subunit BCL11B	Homo sapiens	166-171
28607372-4	2017	Cyclopamine specified the dorsal cortical fate in a dose-dependent manner and enhanced the generation of cortical glutamatergic neurons, expressing PAX6, TBR1, TBR2, CTIP2, SATB2, and vesicular glutamate transporters (vGLUT).	cyclopamine	0-11	SATB homeobox 2	Homo sapiens	173-178
28477008-2	2017	We studied the efficacy and related mechanisms of the combination of cyclopamine (Cyp, a Sonic-hedgehog pathway (Shh) inhibitor) and temozolomide (TMZ, the clinically most used chemotherapeutic agent) in anti-GBM treatment.	cyclopamine	69-80	sonic hedgehog signaling molecule	Homo sapiens	89-111
28477008-2	2017	We studied the efficacy and related mechanisms of the combination of cyclopamine (Cyp, a Sonic-hedgehog pathway (Shh) inhibitor) and temozolomide (TMZ, the clinically most used chemotherapeutic agent) in anti-GBM treatment.	cyclopamine	69-80	sonic hedgehog signaling molecule	Homo sapiens	113-116
28957797-9	2017	These effects were reversed by treatment with the Smo inhibitor cyclopamine, whereas the Sirt1 inhibitor sirtinol reduced the levels of Shh, Ptc-1, Smo, and Gli-1.	cyclopamine	64-75	smoothened, frizzled class receptor	Homo sapiens	50-53
28391011-8	2017	We found that (1) Shh improved neurological scores and reduced infarct volume, which was blocked by Cyclopamine, (2) Shh improved the microvascular density and promoted angiogenesis and neuron survival in the ischemic boundary zone, (3) Shh enhanced VEGF expression and VEGF antibody could reverse angiogenic and protective effect of Shh in vivo and in vitro.	cyclopamine	100-111	sonic hedgehog signaling molecule	Rattus norvegicus	18-21
28380428-4	2017	Inhibiting Akt with LY294002 and siRNA, or inhibiting GLI1 using GANT61, cyclopamine, siRNA and CRISPR/Cas9 resulted in enhanced cell growth suppressive effects of penfluridol.	cyclopamine	73-84	GLI family zinc finger 1	Homo sapiens	54-58
28458545-4	2017	MG63 cells treated with the Smo inhibitor cyclopamine were seeded onto the titanium specimens, and the cell proliferation and differentiation were studied in the presence or absence of cyclopamine.	cyclopamine	42-53	smoothened, frizzled class receptor	Homo sapiens	28-31
28458545-6	2017	The enhanced proliferative activity, ALP production, and expression of the osteogenesis-related genes (bone morphogenetic protein-2, ALP, and runt-related transcription factor 2) enabled by the MNTs were significantly downregulated by the presence of cyclopamine to a similar level as those on the smooth and acid-etched microstructured surfaces in the absence of cyclopamine.	cyclopamine	251-262	bone morphogenetic protein 2	Homo sapiens	103-131
28458545-6	2017	The enhanced proliferative activity, ALP production, and expression of the osteogenesis-related genes (bone morphogenetic protein-2, ALP, and runt-related transcription factor 2) enabled by the MNTs were significantly downregulated by the presence of cyclopamine to a similar level as those on the smooth and acid-etched microstructured surfaces in the absence of cyclopamine.	cyclopamine	251-262	RUNX family transcription factor 2	Homo sapiens	142-177
28458545-6	2017	The enhanced proliferative activity, ALP production, and expression of the osteogenesis-related genes (bone morphogenetic protein-2, ALP, and runt-related transcription factor 2) enabled by the MNTs were significantly downregulated by the presence of cyclopamine to a similar level as those on the smooth and acid-etched microstructured surfaces in the absence of cyclopamine.	cyclopamine	364-375	bone morphogenetic protein 2	Homo sapiens	103-131
27856965-6	2017	Finally, a significant downregulation of Hedgehog pathway readouts Patched-1 and Gli-1 was observed within the IoN after CCI and local injections of cyclopamine, a Hedgehog pathway inhibitor, replicated in naive rats the molecular, vascular, and behavioral changes observed following IoN-CCI.	cyclopamine	149-160	GLI family zinc finger 1	Rattus norvegicus	81-86
28112475-6	2017	Downregulation of Smo activity, using selective Smo inhibitor cyclopamine, lead to a synergistic effect with TMP, whereas Smo overexpression plasmid impaired the induction of antiangiogenesic effects of TMP.	cyclopamine	62-73	smoothened, frizzled class receptor	Homo sapiens	18-21
28591579-7	2017	Arachidonic acid displaces the Smo transmembrane domain inhibitor cyclopamine to rescue CRD agonist-induced signaling, suggesting that arachidonic acid may target the transmembrane bundle to allosterically enhance signaling by CRD agonist-bound Smo.	cyclopamine	66-77	smoothened, frizzled class receptor	Homo sapiens	31-34
28591579-7	2017	Arachidonic acid displaces the Smo transmembrane domain inhibitor cyclopamine to rescue CRD agonist-induced signaling, suggesting that arachidonic acid may target the transmembrane bundle to allosterically enhance signaling by CRD agonist-bound Smo.	cyclopamine	66-77	smoothened, frizzled class receptor	Homo sapiens	245-248
28052321-6	2017	The SMO inhibitor cyclopamine and Gli1 inhibitor GANT-58 reduced expression of VEGF and angiopoietin 1 in HSCs and suppressed HSC tubulogenesis capacity.	cyclopamine	18-29	smoothened, frizzled class receptor	Rattus norvegicus	4-7
28052321-6	2017	The SMO inhibitor cyclopamine and Gli1 inhibitor GANT-58 reduced expression of VEGF and angiopoietin 1 in HSCs and suppressed HSC tubulogenesis capacity.	cyclopamine	18-29	vascular endothelial growth factor A	Rattus norvegicus	79-83
28052321-6	2017	The SMO inhibitor cyclopamine and Gli1 inhibitor GANT-58 reduced expression of VEGF and angiopoietin 1 in HSCs and suppressed HSC tubulogenesis capacity.	cyclopamine	18-29	angiopoietin 1	Rattus norvegicus	88-102
28994542-7	2017	After being interfered with Hh pathway inhibitor (cyclopamine) and Ezhu-containing serum, the expressions of Shh and Gli1 were decreased significantly(compared with the model group, P<0.01).	cyclopamine	50-61	sonic hedgehog signaling molecule	Rattus norvegicus	109-112
28994542-7	2017	After being interfered with Hh pathway inhibitor (cyclopamine) and Ezhu-containing serum, the expressions of Shh and Gli1 were decreased significantly(compared with the model group, P<0.01).	cyclopamine	50-61	GLI family zinc finger 1	Rattus norvegicus	117-121
26738852-7	2017	Intriguingly, in vivo and in vitro inhibition of the Shh signaling pathway with cyclopamine, a Smo inhibitor, completely reversed the above effects of resveratrol.	cyclopamine	80-91	sonic hedgehog signaling molecule	Rattus norvegicus	53-56
28149272-7	2016	Notably, PUR treatment significantly reversed the changes of Shh pathway mediators containing Patched, Gli1, and Shh by SAH insult, and the neuroprotection of PUR on SAH was blocked by Smo antagonist cyclopamine.	cyclopamine	200-211	smoothened, frizzled class receptor	Rattus norvegicus	185-188
27736063-3	2016	Complementary mechanism studies confirmed that 65 inhibits Hh signaling pathway by targeting Smo and shares the same binding site as that of the tool drug cyclopamine.	cyclopamine	155-166	smoothened, frizzled class receptor	Homo sapiens	93-96
26738852-7	2017	Intriguingly, in vivo and in vitro inhibition of the Shh signaling pathway with cyclopamine, a Smo inhibitor, completely reversed the above effects of resveratrol.	cyclopamine	80-91	smoothened, frizzled class receptor	Rattus norvegicus	95-98
27752995-8	2016	Furthermore, cyclopamine treatment could induce inhibition of cell proliferation, invasiveness, and migration and suppression of Smo, Gli1, and VEGF expressions.	cyclopamine	13-24	smoothened, frizzled class receptor	Homo sapiens	129-132
27904711-3	2016	BMSCs were cultured in basal medium, basal medium with naringin, osteogenic induction medium, osteogenic induction medium with naringin and osteogenic induction medium with naringin in the presence of the IHH inhibitor cyclopamine (CPE).	cyclopamine	219-230	Indian hedgehog signaling molecule	Homo sapiens	205-208
28009972-10	2016	We found that cyclopamine significantly upregulated the expression of Sufu.	cyclopamine	14-25	SUFU negative regulator of hedgehog signaling	Mus musculus	70-74
28009972-12	2016	Furthermore, cyclopamine reversed dermal fibrosis induced by TGF-beta1.	cyclopamine	13-24	transforming growth factor, beta 1	Mus musculus	61-70
28009972-13	2016	Cyclopamine and the overexpression of Sufu inhibited the phosphorylation of GSK-3beta and restrained the migration of fibroblasts.	cyclopamine	0-11	glycogen synthase kinase 3 beta	Mus musculus	76-85
28009972-15	2016	Our findings suggest that cyclopamine and Sufu-overexpression may effectively inhibit the endogenous as well as the TGF-beta1-induced activation of fibroblasts through subsequent activation of GSK-3beta.	cyclopamine	26-37	transforming growth factor, beta 1	Mus musculus	116-125
28009972-15	2016	Our findings suggest that cyclopamine and Sufu-overexpression may effectively inhibit the endogenous as well as the TGF-beta1-induced activation of fibroblasts through subsequent activation of GSK-3beta.	cyclopamine	26-37	glycogen synthase kinase 3 beta	Mus musculus	193-202
27752995-8	2016	Furthermore, cyclopamine treatment could induce inhibition of cell proliferation, invasiveness, and migration and suppression of Smo, Gli1, and VEGF expressions.	cyclopamine	13-24	GLI family zinc finger 1	Homo sapiens	134-138
27752995-8	2016	Furthermore, cyclopamine treatment could induce inhibition of cell proliferation, invasiveness, and migration and suppression of Smo, Gli1, and VEGF expressions.	cyclopamine	13-24	vascular endothelial growth factor A	Homo sapiens	144-148
27678330-7	2016	Inhibition by cyclopamine resulted in dose-dependent reduction of Smo and GLI1 and loss of cell viability with a higher magnitude in HPV-positive cells.	cyclopamine	14-25	smoothened, frizzled class receptor	Homo sapiens	66-69
27289556-5	2016	The osteoblastic/cementoblastic differentiation of rh-SHH was abolished by the SHH inhibitor cyclopamine (Cy) and the BMP antagonist noggin.	cyclopamine	93-104	sonic hedgehog signaling molecule	Homo sapiens	54-57
27289556-5	2016	The osteoblastic/cementoblastic differentiation of rh-SHH was abolished by the SHH inhibitor cyclopamine (Cy) and the BMP antagonist noggin.	cyclopamine	93-104	sonic hedgehog signaling molecule	Homo sapiens	79-82
27289556-5	2016	The osteoblastic/cementoblastic differentiation of rh-SHH was abolished by the SHH inhibitor cyclopamine (Cy) and the BMP antagonist noggin.	cyclopamine	106-108	sonic hedgehog signaling molecule	Homo sapiens	54-57
27289556-5	2016	The osteoblastic/cementoblastic differentiation of rh-SHH was abolished by the SHH inhibitor cyclopamine (Cy) and the BMP antagonist noggin.	cyclopamine	106-108	sonic hedgehog signaling molecule	Homo sapiens	79-82
27510750-8	2016	Exogenous SHH reduced the Fgf8 mRNA and protein expression levels, whereas cyclopamine (an SHH-smoothened receptor inhibitor) interfered with SHH-mediated downregulation of Fgf8 expression.	cyclopamine	75-86	sonic hedgehog	Mus musculus	91-94
27510750-8	2016	Exogenous SHH reduced the Fgf8 mRNA and protein expression levels, whereas cyclopamine (an SHH-smoothened receptor inhibitor) interfered with SHH-mediated downregulation of Fgf8 expression.	cyclopamine	75-86	sonic hedgehog	Mus musculus	91-94
27510750-8	2016	Exogenous SHH reduced the Fgf8 mRNA and protein expression levels, whereas cyclopamine (an SHH-smoothened receptor inhibitor) interfered with SHH-mediated downregulation of Fgf8 expression.	cyclopamine	75-86	fibroblast growth factor 8	Mus musculus	173-177
27639396-5	2016	To address these questions, we manipulated Shh signaling using cyclopamine, a potent inhibitor of Shh signaling activator Smoothened (Smo), alone or combined with the agonist SAG in OLG primary cultures and assessed expression of myelin-specific markers.	cyclopamine	63-74	sonic hedgehog signaling molecule	Homo sapiens	43-46
27639396-5	2016	To address these questions, we manipulated Shh signaling using cyclopamine, a potent inhibitor of Shh signaling activator Smoothened (Smo), alone or combined with the agonist SAG in OLG primary cultures and assessed expression of myelin-specific markers.	cyclopamine	63-74	sonic hedgehog signaling molecule	Homo sapiens	98-101
27639396-5	2016	To address these questions, we manipulated Shh signaling using cyclopamine, a potent inhibitor of Shh signaling activator Smoothened (Smo), alone or combined with the agonist SAG in OLG primary cultures and assessed expression of myelin-specific markers.	cyclopamine	63-74	smoothened, frizzled class receptor	Homo sapiens	122-132
27639396-5	2016	To address these questions, we manipulated Shh signaling using cyclopamine, a potent inhibitor of Shh signaling activator Smoothened (Smo), alone or combined with the agonist SAG in OLG primary cultures and assessed expression of myelin-specific markers.	cyclopamine	63-74	smoothened, frizzled class receptor	Homo sapiens	122-125
27639396-7	2016	Co-treatment of the cells with SAG reversed the inhibitory effect of cyclopamine on both myelin-specific protein levels and morphological changes associated with it.	cyclopamine	69-80	S-antigen visual arrestin	Homo sapiens	31-34
27481074-4	2016	The treatment with cyclopamine (a specific inhibitor of Smoothened) or 5E1 (an anti-Shh antibody) not only markedly inhibited the activation of the Shh pathway, but also dramatically suppressed the nephroprotective effects of polydatin above-mentioned.	cyclopamine	19-30	sonic hedgehog signaling molecule	Homo sapiens	84-87
27481074-4	2016	The treatment with cyclopamine (a specific inhibitor of Smoothened) or 5E1 (an anti-Shh antibody) not only markedly inhibited the activation of the Shh pathway, but also dramatically suppressed the nephroprotective effects of polydatin above-mentioned.	cyclopamine	19-30	sonic hedgehog signaling molecule	Homo sapiens	148-151
26917208-0	2016	Activity of ABCG2 Is Regulated by Its Expression and Localization in DHT and Cyclopamine-Treated Breast Cancer Cells.	cyclopamine	77-88	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	12-17
26917208-2	2016	In this study, gene expression analysis identified that treatment of the MCF-7 and T-47D breast cancer cell lines with the androgen, 5alpha-dihydrotestosterone (DHT), and the Hedgehog signaling inhibitor, cyclopamine downregulated ABCG2 mRNA levels.	cyclopamine	205-216	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	231-236
26917208-5	2016	In contrast, cyclopamine, which did not alter ABCG2 protein levels, induced accumulation of ABCG2 in cytoplasmic vesicles, reducing its localization in cell-to-cell junction complexes.	cyclopamine	13-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	92-97
26917208-6	2016	The reduced localization of ABCG2 at the plasma membrane of MCF-7 cells was associated with decreased efflux of the ABCG2 substrate, mitoxantrone, and increased sensitivity of cyclopamine-treated cultures to the cytotoxic effects of mitoxantrone.	cyclopamine	176-187	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	28-33
26917208-7	2016	Together, these findings indicate that DHT and cyclopamine reduce ABCG2 activity in breast cancer cells by distinct mechanisms, providing evidence to advocate the adjunct use of analogous pharmaceutics to increase or prolong the efficacy of breast cancer treatments.	cyclopamine	47-58	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	66-71
27345135-4	2016	RESULTS: Abundant glutamatergic neurons were observed following the treatment with an antagonist of SHH signaling, cyclopamine, while Islet-1 and HB9-expressing motor neurons were enriched by an SHH agonist, purmorphamine.	cyclopamine	115-126	sonic hedgehog signaling molecule	Homo sapiens	100-103
27678330-7	2016	Inhibition by cyclopamine resulted in dose-dependent reduction of Smo and GLI1 and loss of cell viability with a higher magnitude in HPV-positive cells.	cyclopamine	14-25	GLI family zinc finger 1	Homo sapiens	74-78
27316313-7	2016	Furthermore, either knockdown of RET by shRNA or inhibition of HH pathway by cyclopamine attenuates not only basal but also GDNF-induced proliferation of SH-SY5Y cells, and knockdown of either RET or smoothened in SH-SY5Y cell xenografts significantly attenuated the tumor growth.	cyclopamine	77-88	glial cell derived neurotrophic factor	Homo sapiens	124-128
27660224-4	2016	At 48 h after transfection, Smo protein level of siRNA 4 group was 64.8% lower than that of blank control group (P<0.05), and Gli1 protein level of 4 mug/mL cyclopamine group was 68.9% lower than that of blank control group (P<0.05).	cyclopamine	160-171	GLI family zinc finger 1	Homo sapiens	129-133
26459360-3	2016	Here, we revealed that Shh increased neurite outgrowth in primary cortical neurons, while the Shh pathway inhibitor (cyclopamine, CPM) partially suppressed Shh-induced neurite outgrowth.	cyclopamine	117-128	sonic hedgehog signaling molecule	Homo sapiens	94-97
27269880-6	2016	This effect was attenuated when an SHH antagonist, cyclopamine was added, suggesting the involvement of SHH signaling in this process.	cyclopamine	51-62	sonic hedgehog	Gallus gallus	35-38
27269880-6	2016	This effect was attenuated when an SHH antagonist, cyclopamine was added, suggesting the involvement of SHH signaling in this process.	cyclopamine	51-62	sonic hedgehog	Gallus gallus	104-107
26787175-3	2016	The precise mechanism of cyclopamine action remained enigmatic for 30 years, until this steroid alkaloid was found to be the first specific inhibitor of Hedgehog (Hh) signalling and a direct antagonist of the transmembrane receptor Smoothened (SMO).	cyclopamine	25-36	smoothened homolog	Ovis aries	232-242
26787175-3	2016	The precise mechanism of cyclopamine action remained enigmatic for 30 years, until this steroid alkaloid was found to be the first specific inhibitor of Hedgehog (Hh) signalling and a direct antagonist of the transmembrane receptor Smoothened (SMO).	cyclopamine	25-36	smoothened homolog	Ovis aries	244-247
27035418-9	2016	The blockade of SHH signaling with cyclopamine abolished SHH-mediated EMT as well as the acquisition of a myofibroblastic phenotype, and decreased TGF-beta1 expression and ECM production.	cyclopamine	35-46	sonic hedgehog signaling molecule	Rattus norvegicus	16-19
27035418-9	2016	The blockade of SHH signaling with cyclopamine abolished SHH-mediated EMT as well as the acquisition of a myofibroblastic phenotype, and decreased TGF-beta1 expression and ECM production.	cyclopamine	35-46	sonic hedgehog signaling molecule	Rattus norvegicus	57-60
27035418-9	2016	The blockade of SHH signaling with cyclopamine abolished SHH-mediated EMT as well as the acquisition of a myofibroblastic phenotype, and decreased TGF-beta1 expression and ECM production.	cyclopamine	35-46	transforming growth factor, beta 1	Rattus norvegicus	147-156
26779630-10	2016	Gli-1 inhibited by cyclopamine blocked knockdown SET7/9-driven proliferation, migration, and invasion in breast cancer cell.	cyclopamine	19-30	GLI family zinc finger 1	Homo sapiens	0-5
26779630-10	2016	Gli-1 inhibited by cyclopamine blocked knockdown SET7/9-driven proliferation, migration, and invasion in breast cancer cell.	cyclopamine	19-30	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	49-55
26459360-3	2016	Here, we revealed that Shh increased neurite outgrowth in primary cortical neurons, while the Shh pathway inhibitor (cyclopamine, CPM) partially suppressed Shh-induced neurite outgrowth.	cyclopamine	117-128	sonic hedgehog signaling molecule	Homo sapiens	94-97
26979762-2	2016	In vitro directional analysis showed the chemotactic response of NCCs up Shh gradients and to notochord co-cultures (Shh source) or to their conditioned medium, a response inhibited by anti-Shh antibody, receptor inhibitor cyclopamine and anti-Smo morpholino (MO).	cyclopamine	223-234	sonic hedgehog signaling molecule	Homo sapiens	117-120
26710974-5	2016	Results showed that the expression of the critical gene of Hh pathway PTCH and androgen-regulated gene KLK3 was significantly decreased on 3, 6 and 9 days with Hh pathway inhibitor cyclopamine"s treatment.	cyclopamine	181-192	patched 1	Homo sapiens	70-74
26710974-5	2016	Results showed that the expression of the critical gene of Hh pathway PTCH and androgen-regulated gene KLK3 was significantly decreased on 3, 6 and 9 days with Hh pathway inhibitor cyclopamine"s treatment.	cyclopamine	181-192	kallikrein related peptidase 3	Homo sapiens	103-107
26710974-6	2016	MEHP notably up-regulated the expression of PTCH with a dose-response relationship in the presence of cyclopamine, which indicate that MEHP might target on the downstream components of Hh pathway and advance the progression of PCa through activating the Hh pathway.	cyclopamine	102-113	patched 1	Homo sapiens	44-48
26825960-11	2016	Additionally, the blockage of the sonic hedgehog (SHH) pathway by cyclopamine (10  muM) resulted in markedly decreases in DIO3 mRNA levels.	cyclopamine	66-77	sonic hedgehog signaling molecule	Homo sapiens	34-48
26825960-11	2016	Additionally, the blockage of the sonic hedgehog (SHH) pathway by cyclopamine (10  muM) resulted in markedly decreases in DIO3 mRNA levels.	cyclopamine	66-77	sonic hedgehog signaling molecule	Homo sapiens	50-53
26825960-11	2016	Additionally, the blockage of the sonic hedgehog (SHH) pathway by cyclopamine (10  muM) resulted in markedly decreases in DIO3 mRNA levels.	cyclopamine	66-77	latexin	Homo sapiens	83-86
26825960-11	2016	Additionally, the blockage of the sonic hedgehog (SHH) pathway by cyclopamine (10  muM) resulted in markedly decreases in DIO3 mRNA levels.	cyclopamine	66-77	iodothyronine deiodinase 3	Homo sapiens	122-126
26979762-2	2016	In vitro directional analysis showed the chemotactic response of NCCs up Shh gradients and to notochord co-cultures (Shh source) or to their conditioned medium, a response inhibited by anti-Shh antibody, receptor inhibitor cyclopamine and anti-Smo morpholino (MO).	cyclopamine	223-234	sonic hedgehog signaling molecule	Homo sapiens	117-120
26760767-8	2016	In one cell line, SHH-induced cell proliferation was prevented in vitro by either expressing dnKif3a or inhibiting SMO signaling using cyclopamine, and the survival times of mice implanted with dnKif3a-expressing cells were increased.	cyclopamine	135-146	sonic hedgehog	Mus musculus	18-21
26918681-3	2016	To better understand the mechanisms of limb development in anuran amphibians, we used cyclopamine to inhibit Hedgehog signaling at various stages of development in the western clawed frog, Xenopus tropicalis, and observed resulting morphologies.	cyclopamine	86-97	sonic hedgehog	Xenopus tropicalis	109-117
26859575-2	2016	Here, we report that the motility and invasiveness of two anaplastic thyroid tumor cell lines, KAT-18 and SW1736, were inhibited by two inhibitors of the Shh pathway (cyclopamine and GANT61).	cyclopamine	167-178	sonic hedgehog signaling molecule	Homo sapiens	154-157
27158358-5	2016	Pre-treatment with 2 or 5 microM cyclopamine significantly attenuated TGF-beta1-induced rise in the mRNA transcript levels of Gli1, but failed to attenuate TGF-beta1-induced rise in Shh mRNA transcript levels.	cyclopamine	33-44	transforming growth factor beta 1	Homo sapiens	70-79
27158358-5	2016	Pre-treatment with 2 or 5 microM cyclopamine significantly attenuated TGF-beta1-induced rise in the mRNA transcript levels of Gli1, but failed to attenuate TGF-beta1-induced rise in Shh mRNA transcript levels.	cyclopamine	33-44	GLI family zinc finger 1	Homo sapiens	126-130
27158358-6	2016	Additionally, immunoblotting assays and immunofluorescence staining demonstrated that inhibition of Shh signaling by cyclopamine significantly attenuated TGF-beta1-induced increase in the mRNA transcript levels of alpha-SMA, collagen I, and fibronectin.	cyclopamine	117-128	sonic hedgehog signaling molecule	Homo sapiens	100-103
27158358-6	2016	Additionally, immunoblotting assays and immunofluorescence staining demonstrated that inhibition of Shh signaling by cyclopamine significantly attenuated TGF-beta1-induced increase in the mRNA transcript levels of alpha-SMA, collagen I, and fibronectin.	cyclopamine	117-128	transforming growth factor beta 1	Homo sapiens	154-163
27158358-6	2016	Additionally, immunoblotting assays and immunofluorescence staining demonstrated that inhibition of Shh signaling by cyclopamine significantly attenuated TGF-beta1-induced increase in the mRNA transcript levels of alpha-SMA, collagen I, and fibronectin.	cyclopamine	117-128	fibronectin 1	Homo sapiens	241-252
26676748-8	2016	Finally, intravesical instillation of GALNT1 siRNA and the SHH inhibitor cyclopamine exerted potent antitumor activity against bladder tumor growth.	cyclopamine	73-84	sonic hedgehog signaling molecule	Homo sapiens	59-62
25502463-9	2016	Finally, both the SHH pathway inhibitor cyclopamine and its neutralizing antibody attenuated Abeta cytotoxicity, albeit to a minor extent.	cyclopamine	40-51	sonic hedgehog	Mus musculus	18-21
26545965-5	2015	Similar effects were produced by cyclopamine, a regulator of the Shh pathway.	cyclopamine	33-44	sonic hedgehog signaling molecule	Homo sapiens	65-68
26773496-0	2016	Induction of MITF expression in human cholangiocarcinoma cells and hepatocellular carcinoma cells by cyclopamine, an inhibitor of the Hedgehog signaling.	cyclopamine	101-112	melanocyte inducing transcription factor	Homo sapiens	13-17
26773496-6	2016	Moreover, cyclopamine, an inhibitor of the Hedgehog signalling, increased the expression levels of MITF proteins in HuCCT1 and HepG2 cells, but not in KKU-100 cells, suggesting that MITF expression may be down-regulated in some liver cancer cases.	cyclopamine	10-21	melanocyte inducing transcription factor	Homo sapiens	99-103
26773496-6	2016	Moreover, cyclopamine, an inhibitor of the Hedgehog signalling, increased the expression levels of MITF proteins in HuCCT1 and HepG2 cells, but not in KKU-100 cells, suggesting that MITF expression may be down-regulated in some liver cancer cases.	cyclopamine	10-21	melanocyte inducing transcription factor	Homo sapiens	182-186
26674309-6	2016	Inhibition of Shh signaling, by addition of cyclopamine or a function-blocking antibody, resulted in large, ectopic ganglia adjacent to the epithelium.	cyclopamine	44-55	sonic hedgehog signaling molecule	Homo sapiens	14-17
26775700-5	2016	Inhibitors of the Hedgehog/GLI pathway, cyclopamine and GANT61, decreased the promoter activity in reporter assays.	cyclopamine	40-51	GLI family zinc finger 1	Homo sapiens	27-30
27576501-13	2016	Blockade of the Shh pathway in cyclopamine abolished the effects of baicalin in vitro.	cyclopamine	31-42	sonic hedgehog signaling molecule	Rattus norvegicus	16-19
27994624-4	2016	Ihh signal blocking group was set up using Ihh signaling pathway-specific blocking agent cyclopamine.	cyclopamine	89-100	Indian hedgehog signaling molecule	Sus scrofa	0-3
27994624-4	2016	Ihh signal blocking group was set up using Ihh signaling pathway-specific blocking agent cyclopamine.	cyclopamine	89-100	Indian hedgehog signaling molecule	Sus scrofa	43-46
27994624-9	2016	Blocking Ihh signaling with cyclopamine resulted in reduced PTHrP gene expression and protein synthesis and increased Col X gene expression and protein synthesis.	cyclopamine	28-39	Indian hedgehog signaling molecule	Sus scrofa	9-12
26299938-4	2015	However, inhibition of hedgehog signaling with cyclopamine suppressed the adhesion, invasion and migration of GBM cells, accompanied by decreases in mRNA and protein levels of MMP-2 and -9.	cyclopamine	47-58	matrix metallopeptidase 2	Homo sapiens	176-188
26545089-4	2015	The sonic hedgehog inhibitor cyclopamine (50 mg/kg) was given to the LPS-cyclopamine group at 30 min after LPS injection as well as normal mice as control.	cyclopamine	29-40	sonic hedgehog	Mus musculus	4-18
26545089-11	2015	Intervention with cyclopamine in ALI mice led to a reduction in mRNA levels of SHH, PTC, and GLI1 as well as SHH and GLI1 protein levels; meanwhile, the pathological injury scores of lung tissues, thickness of alveolar septa, W/D, and mRNA expression levels of TNF-alpha increased compared with mice receiving LPS only.	cyclopamine	18-29	sonic hedgehog	Mus musculus	79-82
26545089-11	2015	Intervention with cyclopamine in ALI mice led to a reduction in mRNA levels of SHH, PTC, and GLI1 as well as SHH and GLI1 protein levels; meanwhile, the pathological injury scores of lung tissues, thickness of alveolar septa, W/D, and mRNA expression levels of TNF-alpha increased compared with mice receiving LPS only.	cyclopamine	18-29	GLI-Kruppel family member GLI1	Mus musculus	93-97
26545089-11	2015	Intervention with cyclopamine in ALI mice led to a reduction in mRNA levels of SHH, PTC, and GLI1 as well as SHH and GLI1 protein levels; meanwhile, the pathological injury scores of lung tissues, thickness of alveolar septa, W/D, and mRNA expression levels of TNF-alpha increased compared with mice receiving LPS only.	cyclopamine	18-29	sonic hedgehog	Mus musculus	109-112
26545089-11	2015	Intervention with cyclopamine in ALI mice led to a reduction in mRNA levels of SHH, PTC, and GLI1 as well as SHH and GLI1 protein levels; meanwhile, the pathological injury scores of lung tissues, thickness of alveolar septa, W/D, and mRNA expression levels of TNF-alpha increased compared with mice receiving LPS only.	cyclopamine	18-29	GLI-Kruppel family member GLI1	Mus musculus	117-121
26545089-11	2015	Intervention with cyclopamine in ALI mice led to a reduction in mRNA levels of SHH, PTC, and GLI1 as well as SHH and GLI1 protein levels; meanwhile, the pathological injury scores of lung tissues, thickness of alveolar septa, W/D, and mRNA expression levels of TNF-alpha increased compared with mice receiving LPS only.	cyclopamine	18-29	tumor necrosis factor	Mus musculus	261-270
26902390-6	2016	This response was inhibited by cyclopamine and activated by oxysterol 20(S)-hydroxycholesterol, both of which modulate the activity of the Shh co-receptor Smoothened (Smo), demonstrating that Shh-mediated neurite outgrowth is Smo-dependent.	cyclopamine	31-42	sonic hedgehog signaling molecule	Homo sapiens	139-142
26902390-6	2016	This response was inhibited by cyclopamine and activated by oxysterol 20(S)-hydroxycholesterol, both of which modulate the activity of the Shh co-receptor Smoothened (Smo), demonstrating that Shh-mediated neurite outgrowth is Smo-dependent.	cyclopamine	31-42	smoothened, frizzled class receptor	Homo sapiens	155-165
26902390-6	2016	This response was inhibited by cyclopamine and activated by oxysterol 20(S)-hydroxycholesterol, both of which modulate the activity of the Shh co-receptor Smoothened (Smo), demonstrating that Shh-mediated neurite outgrowth is Smo-dependent.	cyclopamine	31-42	smoothened, frizzled class receptor	Homo sapiens	155-158
26902390-6	2016	This response was inhibited by cyclopamine and activated by oxysterol 20(S)-hydroxycholesterol, both of which modulate the activity of the Shh co-receptor Smoothened (Smo), demonstrating that Shh-mediated neurite outgrowth is Smo-dependent.	cyclopamine	31-42	sonic hedgehog signaling molecule	Homo sapiens	192-195
26902390-6	2016	This response was inhibited by cyclopamine and activated by oxysterol 20(S)-hydroxycholesterol, both of which modulate the activity of the Shh co-receptor Smoothened (Smo), demonstrating that Shh-mediated neurite outgrowth is Smo-dependent.	cyclopamine	31-42	smoothened, frizzled class receptor	Homo sapiens	167-170
26405049-8	2015	We show that disc1 is prominently expressed in olig2-positive midline progenitor cells that are absent in smo mutants, while cyclopamine treatment blocks disc1 expression in these cells and mimics the effect of disc1 knock down on OPC specification.	cyclopamine	125-136	DISC1 scaffold protein	Danio rerio	154-159
26319366-5	2015	This toxicity can be produced by numerous Hedgehog antagonists (vismodegib, cyclopamine, and jervine) and is Bax/Bak dependent but p53 independent.	cyclopamine	76-87	BCL2 associated X, apoptosis regulator	Homo sapiens	109-112
26319366-5	2015	This toxicity can be produced by numerous Hedgehog antagonists (vismodegib, cyclopamine, and jervine) and is Bax/Bak dependent but p53 independent.	cyclopamine	76-87	BCL2 antagonist/killer 1	Homo sapiens	113-116
26319366-5	2015	This toxicity can be produced by numerous Hedgehog antagonists (vismodegib, cyclopamine, and jervine) and is Bax/Bak dependent but p53 independent.	cyclopamine	76-87	tumor protein p53	Homo sapiens	131-134
27097426-6	2015	Compared with the model group, after cyclopamine group (Hh pathway inhibitor), Danshen-containing serum and colchicine were interfered, the expression of DYRK2 mRNA and DYRK2 proteins were decreased clearly (P < 0.01), but the expression of SuFu mRNA and SuFu proteins were increased significantly (P < 0.01 or P < 0.05).	cyclopamine	37-48	dual specificity tyrosine phosphorylation regulated kinase 2	Rattus norvegicus	154-159
27097426-6	2015	Compared with the model group, after cyclopamine group (Hh pathway inhibitor), Danshen-containing serum and colchicine were interfered, the expression of DYRK2 mRNA and DYRK2 proteins were decreased clearly (P < 0.01), but the expression of SuFu mRNA and SuFu proteins were increased significantly (P < 0.01 or P < 0.05).	cyclopamine	37-48	dual specificity tyrosine phosphorylation regulated kinase 2	Rattus norvegicus	169-174
27097426-6	2015	Compared with the model group, after cyclopamine group (Hh pathway inhibitor), Danshen-containing serum and colchicine were interfered, the expression of DYRK2 mRNA and DYRK2 proteins were decreased clearly (P < 0.01), but the expression of SuFu mRNA and SuFu proteins were increased significantly (P < 0.01 or P < 0.05).	cyclopamine	37-48	SUFU negative regulator of hedgehog signaling	Rattus norvegicus	244-248
27097426-6	2015	Compared with the model group, after cyclopamine group (Hh pathway inhibitor), Danshen-containing serum and colchicine were interfered, the expression of DYRK2 mRNA and DYRK2 proteins were decreased clearly (P < 0.01), but the expression of SuFu mRNA and SuFu proteins were increased significantly (P < 0.01 or P < 0.05).	cyclopamine	37-48	SUFU negative regulator of hedgehog signaling	Rattus norvegicus	258-262
25154865-6	2015	In silkworm larval models, enhanced adipocyte differentiation and an increase in adipocyte cell size were observed in silkworms that had been treated with a specific Hh signaling pathway antagonist, cyclopamine.	cyclopamine	199-210	desert hedgehog protein B	Bombyx mori	166-168
26254735-6	2015	This effect was accompanied by reduction of AICD and Ptch1 levels and was prevented by inhibition of the Shh pathway with cyclopamine.	cyclopamine	122-133	sonic hedgehog	Mus musculus	105-108
26405049-8	2015	We show that disc1 is prominently expressed in olig2-positive midline progenitor cells that are absent in smo mutants, while cyclopamine treatment blocks disc1 expression in these cells and mimics the effect of disc1 knock down on OPC specification.	cyclopamine	125-136	DISC1 scaffold protein	Danio rerio	154-159
26393651-6	2015	Consistent with a role for HH in regulating the invasive potential we show that cyclopamine reduces the expression of transcription factors (Slug, Snail and Twist) associated with the epithelial-mesenchymal transition and reduces the invasiveness of colorectal cancer cells in vitro.	cyclopamine	80-91	snail family transcriptional repressor 1	Homo sapiens	147-152
25820869-9	2015	After 3-day administration with b-FGF, exendin-4, and cyclopamine, Pdx1-high/Shh-low cells were differentiated from CXCR4(+) cells.	cyclopamine	54-65	chemokine (C-X-C motif) receptor 4	Mus musculus	116-121
26393651-0	2015	The Hedgehog Inhibitor Cyclopamine Reduces beta-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells.	cyclopamine	23-34	catenin beta 1	Homo sapiens	43-55
26393651-0	2015	The Hedgehog Inhibitor Cyclopamine Reduces beta-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells.	cyclopamine	23-34	hepatocyte nuclear factor 4 alpha	Homo sapiens	56-59
26393651-0	2015	The Hedgehog Inhibitor Cyclopamine Reduces beta-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells.	cyclopamine	23-34	cadherin 1	Homo sapiens	94-104
26393651-4	2015	We now show that cyclopamine treatment reduces beta-catenin related transcription in colorectal cancer cell lines, and that this effect can be reversed by addition of Sonic Hedgehog protein.	cyclopamine	17-28	catenin beta 1	Homo sapiens	47-59
26393651-4	2015	We now show that cyclopamine treatment reduces beta-catenin related transcription in colorectal cancer cell lines, and that this effect can be reversed by addition of Sonic Hedgehog protein.	cyclopamine	17-28	sonic hedgehog signaling molecule	Homo sapiens	167-189
26393651-5	2015	We also show that cyclopamine concomitantly induces expression of the tumour suppressor and prognostic indicator E-cadherin.	cyclopamine	18-29	cadherin 1	Homo sapiens	113-123
26393651-6	2015	Consistent with a role for HH in regulating the invasive potential we show that cyclopamine reduces the expression of transcription factors (Slug, Snail and Twist) associated with the epithelial-mesenchymal transition and reduces the invasiveness of colorectal cancer cells in vitro.	cyclopamine	80-91	snail family transcriptional repressor 2	Homo sapiens	141-145
26113054-6	2015	Furthermore, we identified that AT-101 potentially acted on smoothened (Smo) by sharing the same binding site with cyclopamine, a classical Hh signaling pathway inhibitor.	cyclopamine	115-126	smoothened, frizzled class receptor	Mus musculus	60-70
26113054-6	2015	Furthermore, we identified that AT-101 potentially acted on smoothened (Smo) by sharing the same binding site with cyclopamine, a classical Hh signaling pathway inhibitor.	cyclopamine	115-126	smoothened, frizzled class receptor	Mus musculus	72-75
24768363-12	2015	Moreover, cyclopamine significantly increased TGF-beta1 mRNA expression by 2.6 +- 0.9-fold.	cyclopamine	10-21	transforming growth factor beta 1	Homo sapiens	46-55
26218245-4	2015	We confirmed the interaction between these pathways, as cyclopamine inhibition of Hedgehog function impairs both PDGF-mediated OPC proliferation and Shh-dependent cell branching.	cyclopamine	56-67	sonic hedgehog signaling molecule	Rattus norvegicus	149-152
25682950-11	2015	When combined with cyclopamine, irradiation inhibited Gli-1 and increased DNA double-strand breakage.	cyclopamine	19-30	GLI family zinc finger 1	Homo sapiens	54-59
26146059-8	2015	After cyclopamine intervention, the mRNA levels of SHH, PTC and GLI1 and the protein levels of SHH and GLI1 were all reduced, while pathological injury score of lung tissues, W/D and mRNA level of TNF-alpha were obviously higher than those in the LPS-treated group.	cyclopamine	6-17	sonic hedgehog	Mus musculus	51-54
25645065-4	2015	KEY FINDINGS: Cyclopamine effectively attenuated inflammation and cartilage damage of AIA rats, as evidenced by reduced paw swelling, serum levels of tumor necrosis factors (TNF)-alpha, IL-1beta, IL-6 and histological scores of joint damage, increased proteoglycans expression and mRNA levels of COII and aggrecan in articular cartilage.	cyclopamine	14-25	tumor necrosis factor	Rattus norvegicus	174-184
25645065-4	2015	KEY FINDINGS: Cyclopamine effectively attenuated inflammation and cartilage damage of AIA rats, as evidenced by reduced paw swelling, serum levels of tumor necrosis factors (TNF)-alpha, IL-1beta, IL-6 and histological scores of joint damage, increased proteoglycans expression and mRNA levels of COII and aggrecan in articular cartilage.	cyclopamine	14-25	interleukin 1 beta	Rattus norvegicus	186-194
25645065-4	2015	KEY FINDINGS: Cyclopamine effectively attenuated inflammation and cartilage damage of AIA rats, as evidenced by reduced paw swelling, serum levels of tumor necrosis factors (TNF)-alpha, IL-1beta, IL-6 and histological scores of joint damage, increased proteoglycans expression and mRNA levels of COII and aggrecan in articular cartilage.	cyclopamine	14-25	interleukin 6	Rattus norvegicus	196-200
25645065-4	2015	KEY FINDINGS: Cyclopamine effectively attenuated inflammation and cartilage damage of AIA rats, as evidenced by reduced paw swelling, serum levels of tumor necrosis factors (TNF)-alpha, IL-1beta, IL-6 and histological scores of joint damage, increased proteoglycans expression and mRNA levels of COII and aggrecan in articular cartilage.	cyclopamine	14-25	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	296-300
26146059-8	2015	After cyclopamine intervention, the mRNA levels of SHH, PTC and GLI1 and the protein levels of SHH and GLI1 were all reduced, while pathological injury score of lung tissues, W/D and mRNA level of TNF-alpha were obviously higher than those in the LPS-treated group.	cyclopamine	6-17	GLI-Kruppel family member GLI1	Mus musculus	64-68
26146059-8	2015	After cyclopamine intervention, the mRNA levels of SHH, PTC and GLI1 and the protein levels of SHH and GLI1 were all reduced, while pathological injury score of lung tissues, W/D and mRNA level of TNF-alpha were obviously higher than those in the LPS-treated group.	cyclopamine	6-17	sonic hedgehog	Mus musculus	95-98
26146059-8	2015	After cyclopamine intervention, the mRNA levels of SHH, PTC and GLI1 and the protein levels of SHH and GLI1 were all reduced, while pathological injury score of lung tissues, W/D and mRNA level of TNF-alpha were obviously higher than those in the LPS-treated group.	cyclopamine	6-17	GLI-Kruppel family member GLI1	Mus musculus	103-107
26146059-8	2015	After cyclopamine intervention, the mRNA levels of SHH, PTC and GLI1 and the protein levels of SHH and GLI1 were all reduced, while pathological injury score of lung tissues, W/D and mRNA level of TNF-alpha were obviously higher than those in the LPS-treated group.	cyclopamine	6-17	tumor necrosis factor	Mus musculus	197-206
25898852-4	2015	With a double emulsion method, a nano delivery system was constructed to deliver doxorubicin (DOX) and cyclopamine (CYC, a primary inhibitor of the hedgehog signaling pathway of CSCs) to both a CD44-overexpressing breast CSC subpopulation and bulk breast cancer cells and allow an on-demand release.	cyclopamine	103-114	cytochrome c, somatic	Homo sapiens	116-119
25406358-6	2015	TNF-alpha significantly increased the expression of Shh signalling components in EA.hy926 endothelial cells, while cyclopamine decreased the expression of Shh signalling components.	cyclopamine	115-126	sonic hedgehog signaling molecule	Homo sapiens	155-158
25406358-7	2015	EA.hy926 endothelial cells treated with various concentrations of cyclopamine (2-8 mumol/l) showed a significant decrease in cell viability and cell survival rate, and an increase in the rate of cell apoptosis compared with endothelial cells treated with TNF-alpha and ActD (P < 0.05).	cyclopamine	66-77	tumor necrosis factor	Homo sapiens	255-264
25872645-8	2015	Furthermore, the BMP9-induced transcriptional activity of Smad1/5/8 and the expression of pivotal osteogenic transcription factors were reduced by cyclopamine, and were increased by purmorphamine.	cyclopamine	147-158	growth differentiation factor 2	Homo sapiens	17-21
25872645-8	2015	Furthermore, the BMP9-induced transcriptional activity of Smad1/5/8 and the expression of pivotal osteogenic transcription factors were reduced by cyclopamine, and were increased by purmorphamine.	cyclopamine	147-158	SMAD family member 1	Homo sapiens	58-67
25936695-2	2015	Cyclopamine (CPA), a potent inhibitor for sonic hedgehog pathway (SHH), shows great promises in PDAC treatment, including the disruption of tumor-associated stroma, and enhancement of radiation therapy.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	66-69
25936695-2	2015	Cyclopamine (CPA), a potent inhibitor for sonic hedgehog pathway (SHH), shows great promises in PDAC treatment, including the disruption of tumor-associated stroma, and enhancement of radiation therapy.	cyclopamine	13-16	sonic hedgehog signaling molecule	Homo sapiens	66-69
25936695-6	2015	The results showed that M-CPA had higher cytotoxicity than CPA, abolished Gli-1 expression (a key component of SHH), and enhanced the radiation therapy of Cs-137.	cyclopamine	26-29	GLI family zinc finger 1	Homo sapiens	74-79
25936695-6	2015	The results showed that M-CPA had higher cytotoxicity than CPA, abolished Gli-1 expression (a key component of SHH), and enhanced the radiation therapy of Cs-137.	cyclopamine	26-29	sonic hedgehog signaling molecule	Homo sapiens	111-114
25843803-7	2015	Moreover, we demonstrated that downregulation of TRIM16 activated the sonic hedgehog pathway, and that inhibition of the sonic hedgehog pathway by cyclopamine abrogated the effect of TRIM16-downregulation induced EMT and metastasis on NSCLC cells.	cyclopamine	147-158	tripartite motif containing 16	Homo sapiens	183-189
25898852-4	2015	With a double emulsion method, a nano delivery system was constructed to deliver doxorubicin (DOX) and cyclopamine (CYC, a primary inhibitor of the hedgehog signaling pathway of CSCs) to both a CD44-overexpressing breast CSC subpopulation and bulk breast cancer cells and allow an on-demand release.	cyclopamine	103-114	CD44 molecule (Indian blood group)	Homo sapiens	194-198
25519748-5	2015	More importantly, pharmacological inhibition of Hedgehog signaling with cyclopamine or knockdown of IHH almost completely blocked TGFbeta1-induced chondrogenesis in hBMSCs, demonstrating that endogenously produced IHH is necessary for hBMSC chondrogenesis.	cyclopamine	72-83	Indian hedgehog signaling molecule	Homo sapiens	214-217
26137001-5	2015	Furthermore, the secretion of TGF-beta1 was significantly reduced following the administration of cyclopamine to the AGS cells.	cyclopamine	98-109	transforming growth factor beta 1	Homo sapiens	30-39
26137075-11	2015	The RT-PCR and western blotting showed a decrease in Gli-1, Snail and N-cadherin expression, and an increase in E-cadherin expression in the resveratrol and cyclopamine group compared with the control group, suggesting that resveratrol inhibited the Hh pathway and EMT, as did cyclopamine.	cyclopamine	157-168	snail family transcriptional repressor 1	Homo sapiens	60-65
26137075-11	2015	The RT-PCR and western blotting showed a decrease in Gli-1, Snail and N-cadherin expression, and an increase in E-cadherin expression in the resveratrol and cyclopamine group compared with the control group, suggesting that resveratrol inhibited the Hh pathway and EMT, as did cyclopamine.	cyclopamine	157-168	cadherin 2	Homo sapiens	70-80
26137075-11	2015	The RT-PCR and western blotting showed a decrease in Gli-1, Snail and N-cadherin expression, and an increase in E-cadherin expression in the resveratrol and cyclopamine group compared with the control group, suggesting that resveratrol inhibited the Hh pathway and EMT, as did cyclopamine.	cyclopamine	157-168	cadherin 1	Homo sapiens	112-122
25813994-8	2015	Exogenous SHH increased the mRNA and protein expression of SHH, SMO, and GLI1 and cyclopamine reversed that effect.	cyclopamine	82-93	sonic hedgehog signaling molecule	Rattus norvegicus	10-13
25821409-14	2015	In vitro, cyclopamine effectively decreased the mRNA levels of Shh, Ptch1, Smo and Gli1, and increased the mRNA levels of COII and aggrecan in AIA chondrocytes, suggesting Hh signal inhibition might directly promote ECM production.	cyclopamine	10-21	sonic hedgehog signaling molecule	Rattus norvegicus	63-66
25500071-8	2015	As vitamin D has been reported to be an inhibitor of hedgehog (Hh) signaling through Smo, we tested the effect of cyclopamine, an established inhibitor of the Hh pathway, on DHCR7 activity.	cyclopamine	114-125	7-dehydrocholesterol reductase	Homo sapiens	174-179
25680941-8	2015	To test this hypothesis, a loss-of-function study using cyclopamine, an inhibitor of the sonic hedgehog (Shh) pathway, was employed in vivo.	cyclopamine	56-67	sonic hedgehog	Mus musculus	89-103
25680941-8	2015	To test this hypothesis, a loss-of-function study using cyclopamine, an inhibitor of the sonic hedgehog (Shh) pathway, was employed in vivo.	cyclopamine	56-67	sonic hedgehog	Mus musculus	105-108
25680941-13	2015	However, combination treatment of EAE mice with cyclopamine-Fingolimod decreased Fingolimod monotherapy elevated protein levels of Smoothened and Gli1, and abolished the effect of Fingolimod on OPC proliferation and differentiation, as well as on neurological function outcome.	cyclopamine	48-59	smoothened, frizzled class receptor	Mus musculus	131-141
25680941-13	2015	However, combination treatment of EAE mice with cyclopamine-Fingolimod decreased Fingolimod monotherapy elevated protein levels of Smoothened and Gli1, and abolished the effect of Fingolimod on OPC proliferation and differentiation, as well as on neurological function outcome.	cyclopamine	48-59	GLI-Kruppel family member GLI1	Mus musculus	146-150
25821409-14	2015	In vitro, cyclopamine effectively decreased the mRNA levels of Shh, Ptch1, Smo and Gli1, and increased the mRNA levels of COII and aggrecan in AIA chondrocytes, suggesting Hh signal inhibition might directly promote ECM production.	cyclopamine	10-21	patched 1	Rattus norvegicus	68-73
25821409-14	2015	In vitro, cyclopamine effectively decreased the mRNA levels of Shh, Ptch1, Smo and Gli1, and increased the mRNA levels of COII and aggrecan in AIA chondrocytes, suggesting Hh signal inhibition might directly promote ECM production.	cyclopamine	10-21	smoothened, frizzled class receptor	Rattus norvegicus	75-78
25821409-14	2015	In vitro, cyclopamine effectively decreased the mRNA levels of Shh, Ptch1, Smo and Gli1, and increased the mRNA levels of COII and aggrecan in AIA chondrocytes, suggesting Hh signal inhibition might directly promote ECM production.	cyclopamine	10-21	GLI family zinc finger 1	Rattus norvegicus	83-87
25821409-14	2015	In vitro, cyclopamine effectively decreased the mRNA levels of Shh, Ptch1, Smo and Gli1, and increased the mRNA levels of COII and aggrecan in AIA chondrocytes, suggesting Hh signal inhibition might directly promote ECM production.	cyclopamine	10-21	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	122-126
25750281-8	2015	YangZheng XiaoJi and its combination with cyclopamine also significantly reduced the growth of lung tumors in vivo together with a reduction of SHH and smoothened (Smo) proteins in the lung tumors.	cyclopamine	42-53	sonic hedgehog signaling molecule	Homo sapiens	144-147
25859319-5	2015	RESULTS: We have addressed this issue by treating tadpoles with Shh inhibitor cyclopamine.	cyclopamine	78-89	sonic hedgehog signaling molecule	Homo sapiens	64-67
25859319-6	2015	We showed that cyclopamine but not the structurally related chemical tomatidine inhibited the expression of Shh response genes BMP4, Snai2, and Twist1.	cyclopamine	15-26	sonic hedgehog signaling molecule	Homo sapiens	108-111
25859319-6	2015	We showed that cyclopamine but not the structurally related chemical tomatidine inhibited the expression of Shh response genes BMP4, Snai2, and Twist1.	cyclopamine	15-26	bone morphogenetic protein 4	Homo sapiens	127-131
25859319-6	2015	We showed that cyclopamine but not the structurally related chemical tomatidine inhibited the expression of Shh response genes BMP4, Snai2, and Twist1.	cyclopamine	15-26	snail family transcriptional repressor 2	Homo sapiens	133-138
25859319-6	2015	We showed that cyclopamine but not the structurally related chemical tomatidine inhibited the expression of Shh response genes BMP4, Snai2, and Twist1.	cyclopamine	15-26	twist family bHLH transcription factor 1	Homo sapiens	144-150
25774684-6	2015	Addition of retinoic acid (RA), Noggin and Cyclopamine promoted pancreatic differentiation as indicated by the expression of the early pancreatic progenitor markers ISL1, NGN3 and PDX1.	cyclopamine	43-54	ISL LIM homeobox 1	Homo sapiens	165-169
25774684-6	2015	Addition of retinoic acid (RA), Noggin and Cyclopamine promoted pancreatic differentiation as indicated by the expression of the early pancreatic progenitor markers ISL1, NGN3 and PDX1.	cyclopamine	43-54	neurogenin 3	Homo sapiens	171-175
25774684-6	2015	Addition of retinoic acid (RA), Noggin and Cyclopamine promoted pancreatic differentiation as indicated by the expression of the early pancreatic progenitor markers ISL1, NGN3 and PDX1.	cyclopamine	43-54	pancreatic and duodenal homeobox 1	Homo sapiens	180-184
24747971-4	2015	We also demonstrate that BBS activates Gli in SCLC cells, which is crucial for BBS-mediated SCLC proliferation, because cyclopamine, an inhibitor of the Shh pathway, hampered the BBS-mediated effects.	cyclopamine	120-131	gastrin releasing peptide	Homo sapiens	25-28
24747971-4	2015	We also demonstrate that BBS activates Gli in SCLC cells, which is crucial for BBS-mediated SCLC proliferation, because cyclopamine, an inhibitor of the Shh pathway, hampered the BBS-mediated effects.	cyclopamine	120-131	GLI family zinc finger 1	Homo sapiens	39-42
24747971-4	2015	We also demonstrate that BBS activates Gli in SCLC cells, which is crucial for BBS-mediated SCLC proliferation, because cyclopamine, an inhibitor of the Shh pathway, hampered the BBS-mediated effects.	cyclopamine	120-131	gastrin releasing peptide	Homo sapiens	79-82
24747971-4	2015	We also demonstrate that BBS activates Gli in SCLC cells, which is crucial for BBS-mediated SCLC proliferation, because cyclopamine, an inhibitor of the Shh pathway, hampered the BBS-mediated effects.	cyclopamine	120-131	sonic hedgehog signaling molecule	Homo sapiens	153-156
24747971-4	2015	We also demonstrate that BBS activates Gli in SCLC cells, which is crucial for BBS-mediated SCLC proliferation, because cyclopamine, an inhibitor of the Shh pathway, hampered the BBS-mediated effects.	cyclopamine	120-131	gastrin releasing peptide	Homo sapiens	79-82
25750281-8	2015	YangZheng XiaoJi and its combination with cyclopamine also significantly reduced the growth of lung tumors in vivo together with a reduction of SHH and smoothened (Smo) proteins in the lung tumors.	cyclopamine	42-53	smoothened, frizzled class receptor	Homo sapiens	152-162
25750281-8	2015	YangZheng XiaoJi and its combination with cyclopamine also significantly reduced the growth of lung tumors in vivo together with a reduction of SHH and smoothened (Smo) proteins in the lung tumors.	cyclopamine	42-53	smoothened, frizzled class receptor	Homo sapiens	164-167
25557621-8	2015	Consistent with these results, coloboma in sox4 morphants could be rescued by pharmacological treatment with the Hh inhibitor cyclopamine, or by co-knockdown of ihhb.	cyclopamine	126-137	SRY-box transcription factor 4a	Danio rerio	43-47
25595187-7	2015	Cyclopamine, a Hedgehog/Smoothened (SMO) inhibitor, reversed the protective effect of Shh in U87MG cells.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	15-34
25595187-7	2015	Cyclopamine, a Hedgehog/Smoothened (SMO) inhibitor, reversed the protective effect of Shh in U87MG cells.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	36-39
25595187-7	2015	Cyclopamine, a Hedgehog/Smoothened (SMO) inhibitor, reversed the protective effect of Shh in U87MG cells.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	86-89
25595187-8	2015	Cyclopamine increased Shh plus IR-induced H2AX, a marker of DNA double-strand breaks, in these cells.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	22-25
25595187-8	2015	Cyclopamine increased Shh plus IR-induced H2AX, a marker of DNA double-strand breaks, in these cells.	cyclopamine	0-11	H2A.X variant histone	Homo sapiens	42-46
26380286-7	2015	Furthermore, TMP can inhibit the expression of connective tissue growth factor (CTGF), and the inhibitory effect was intensified after the application of joint treatment with TMP and cyclopamine.	cyclopamine	183-194	cellular communication network factor 2	Rattus norvegicus	47-78
25576868-8	2015	Hedgehog stimulation and nutritional deprivation synergistically enhanced GLI1 transcription levels, and this was blocked more efficiently by vismodegib, a SMO inhibitor, than by the natural compound, cyclopamine.	cyclopamine	201-212	hedgehog	Drosophila melanogaster	0-8
25576868-8	2015	Hedgehog stimulation and nutritional deprivation synergistically enhanced GLI1 transcription levels, and this was blocked more efficiently by vismodegib, a SMO inhibitor, than by the natural compound, cyclopamine.	cyclopamine	201-212	GLI family zinc finger 1	Homo sapiens	74-78
25716561-9	2015	Furthermore, depletion of Gli1 by siRNA and cyclopamine (a specific SMO inhibitor) induced autophagy.	cyclopamine	44-55	smoothened, frizzled class receptor	Homo sapiens	68-71
25961032-6	2015	The survival of astrocytes pretreated with Shh was significantly elevated in cocultures with the antigens but reduced by its inhibitor cyclopamine.	cyclopamine	135-146	sonic hedgehog	Mus musculus	43-46
26380286-7	2015	Furthermore, TMP can inhibit the expression of connective tissue growth factor (CTGF), and the inhibitory effect was intensified after the application of joint treatment with TMP and cyclopamine.	cyclopamine	183-194	cellular communication network factor 2	Rattus norvegicus	80-84
25871875-9	2015	At the same time, the expression of Patched-1, Smoothened (Smo), and Gli-1 proteins and mRNAs was upregulated, and Gli-1 entered the nucleus, which was inhibited by cyclopamine, a Smo inhibitor.	cyclopamine	165-176	patched 1	Rattus norvegicus	36-45
25871875-9	2015	At the same time, the expression of Patched-1, Smoothened (Smo), and Gli-1 proteins and mRNAs was upregulated, and Gli-1 entered the nucleus, which was inhibited by cyclopamine, a Smo inhibitor.	cyclopamine	165-176	GLI family zinc finger 1	Rattus norvegicus	115-120
25871875-9	2015	At the same time, the expression of Patched-1, Smoothened (Smo), and Gli-1 proteins and mRNAs was upregulated, and Gli-1 entered the nucleus, which was inhibited by cyclopamine, a Smo inhibitor.	cyclopamine	165-176	smoothened, frizzled class receptor	Rattus norvegicus	47-57
25871875-9	2015	At the same time, the expression of Patched-1, Smoothened (Smo), and Gli-1 proteins and mRNAs was upregulated, and Gli-1 entered the nucleus, which was inhibited by cyclopamine, a Smo inhibitor.	cyclopamine	165-176	smoothened, frizzled class receptor	Rattus norvegicus	59-62
25871875-9	2015	At the same time, the expression of Patched-1, Smoothened (Smo), and Gli-1 proteins and mRNAs was upregulated, and Gli-1 entered the nucleus, which was inhibited by cyclopamine, a Smo inhibitor.	cyclopamine	165-176	smoothened, frizzled class receptor	Rattus norvegicus	47-50
25871875-9	2015	At the same time, the expression of Patched-1, Smoothened (Smo), and Gli-1 proteins and mRNAs was upregulated, and Gli-1 entered the nucleus, which was inhibited by cyclopamine, a Smo inhibitor.	cyclopamine	165-176	GLI family zinc finger 1	Rattus norvegicus	69-74
25861282-4	2015	The Shh signaling inhibitor, cyclopamine, inhibited high-risk MDS BMSC-induced survival of SKM-1 and MUTZ-1 cells, suggesting a role for Shh signaling in MDS cell survival.	cyclopamine	29-40	sonic hedgehog signaling molecule	Homo sapiens	4-7
25280457-3	2015	An inhibitor of this pathway is the steroidal alkaloid cyclopamine, an antagonist of the Hh coreceptor Smoothened (SMO).	cyclopamine	55-66	smoothened, frizzled class receptor	Rattus norvegicus	103-113
25280457-3	2015	An inhibitor of this pathway is the steroidal alkaloid cyclopamine, an antagonist of the Hh coreceptor Smoothened (SMO).	cyclopamine	55-66	smoothened, frizzled class receptor	Rattus norvegicus	115-118
25280457-4	2015	To limit the toxicity of cyclopamine toward Hh-dependent non-tumor cells, our group previously reported the synthesis of a prodrug (called 1b), designed to deliver cyclopamine in the presence of beta-glucuronidase, an enzyme found in the necrotic area of GBM.	cyclopamine	25-36	glucuronidase, beta	Rattus norvegicus	195-213
25861282-4	2015	The Shh signaling inhibitor, cyclopamine, inhibited high-risk MDS BMSC-induced survival of SKM-1 and MUTZ-1 cells, suggesting a role for Shh signaling in MDS cell survival.	cyclopamine	29-40	sodium voltage-gated channel alpha subunit 4	Homo sapiens	91-96
25861282-4	2015	The Shh signaling inhibitor, cyclopamine, inhibited high-risk MDS BMSC-induced survival of SKM-1 and MUTZ-1 cells, suggesting a role for Shh signaling in MDS cell survival.	cyclopamine	29-40	sonic hedgehog signaling molecule	Homo sapiens	137-140
25861282-5	2015	Furthermore, cyclopamine-mediated inhibition of Shh signaling in SKM-1 and MUTZ-1 cells resulted in decreased DNMT1 expression and cell survival; however, exogenous Shh peptide had the opposite effect, suggesting that Shh signaling could regulate the expression of DNMT1, thereby modulating cell survival in MDS.	cyclopamine	13-24	sonic hedgehog signaling molecule	Homo sapiens	48-51
25861282-5	2015	Furthermore, cyclopamine-mediated inhibition of Shh signaling in SKM-1 and MUTZ-1 cells resulted in decreased DNMT1 expression and cell survival; however, exogenous Shh peptide had the opposite effect, suggesting that Shh signaling could regulate the expression of DNMT1, thereby modulating cell survival in MDS.	cyclopamine	13-24	sodium voltage-gated channel alpha subunit 4	Homo sapiens	65-70
25861282-5	2015	Furthermore, cyclopamine-mediated inhibition of Shh signaling in SKM-1 and MUTZ-1 cells resulted in decreased DNMT1 expression and cell survival; however, exogenous Shh peptide had the opposite effect, suggesting that Shh signaling could regulate the expression of DNMT1, thereby modulating cell survival in MDS.	cyclopamine	13-24	DNA methyltransferase 1	Homo sapiens	110-115
25861282-5	2015	Furthermore, cyclopamine-mediated inhibition of Shh signaling in SKM-1 and MUTZ-1 cells resulted in decreased DNMT1 expression and cell survival; however, exogenous Shh peptide had the opposite effect, suggesting that Shh signaling could regulate the expression of DNMT1, thereby modulating cell survival in MDS.	cyclopamine	13-24	sonic hedgehog signaling molecule	Homo sapiens	165-168
25861282-5	2015	Furthermore, cyclopamine-mediated inhibition of Shh signaling in SKM-1 and MUTZ-1 cells resulted in decreased DNMT1 expression and cell survival; however, exogenous Shh peptide had the opposite effect, suggesting that Shh signaling could regulate the expression of DNMT1, thereby modulating cell survival in MDS.	cyclopamine	13-24	sonic hedgehog signaling molecule	Homo sapiens	165-168
25861282-5	2015	Furthermore, cyclopamine-mediated inhibition of Shh signaling in SKM-1 and MUTZ-1 cells resulted in decreased DNMT1 expression and cell survival; however, exogenous Shh peptide had the opposite effect, suggesting that Shh signaling could regulate the expression of DNMT1, thereby modulating cell survival in MDS.	cyclopamine	13-24	DNA methyltransferase 1	Homo sapiens	265-270
25861282-6	2015	In addition, the apoptosis of SKM-1 and MUTZ-1 cell increased significantly when cultured with cyclopamine and a demethylation agent, 5-Aza-2"-deoxycytidine.	cyclopamine	95-106	sodium voltage-gated channel alpha subunit 4	Homo sapiens	30-35
25503972-0	2014	Combination of cyclopamine and tamoxifen promotes survival and migration of mcf-7 breast cancer cells--interaction of hedgehog-gli and estrogen receptor signaling pathways.	cyclopamine	15-26	GLI family zinc finger 1	Homo sapiens	127-130
25503972-4	2014	ER-positive MCF-7 cells show decreased viability after treatment with cyclopamine, a Hh-Gli pathway inhibitor, as well as after tamoxifen (an ERalpha inhibitor) treatment.	cyclopamine	70-81	GLI family zinc finger 1	Homo sapiens	88-91
25297633-4	2014	Hh pathway blockade with cyclopamine suppressed GLI1 activation and enhanced tumor sensitivity to radiotherapy.	cyclopamine	25-36	GLI family zinc finger 1	Homo sapiens	48-52
24862798-0	2014	Inhibitory potential of postnatal treatment with cyclopamine, a hedgehog signaling inhibitor, on medulloblastoma development in Ptch1 heterozygous mice.	cyclopamine	49-60	patched 1	Mus musculus	128-133
24862798-3	2014	The present study was conducted to evaluate postnatal effects of a Shh signaling inhibitor, cyclopamine, on the development of MBs in Ptch1 mice.	cyclopamine	92-103	sonic hedgehog	Mus musculus	67-70
24862798-3	2014	The present study was conducted to evaluate postnatal effects of a Shh signaling inhibitor, cyclopamine, on the development of MBs in Ptch1 mice.	cyclopamine	92-103	patched 1	Mus musculus	134-139
24862798-4	2014	Ptch1 and wild-type mice were treated daily with subcutaneous cyclopamine at 40 mg/kg or vehicle from postnatal day (PND) 1 to PND14, and the subsequent development of MBs and preneoplastic lesions was examined up to week 12 (W12).	cyclopamine	62-73	patched 1	Mus musculus	0-5
25623978-0	2014	[Expression of sonic hedgehog signaling pathw ay and its inhibition by cyclopamine in rat liver with chronic fluorosis].	cyclopamine	71-82	sonic hedgehog signaling molecule	Rattus norvegicus	15-29
25356787-7	2014	Real-time RT-PCR showed whereas both Shh and DHT induced N-cadherin and vimentin, DHT also induced the expression of osteonectin in LNCaP and cyclopamine blocked these expressions in osteonectin, N-cadherin and vimentin (p = 0.0084, 0.0002 and 0.0373, respectively).	cyclopamine	142-153	sonic hedgehog signaling molecule	Homo sapiens	37-40
25356787-7	2014	Real-time RT-PCR showed whereas both Shh and DHT induced N-cadherin and vimentin, DHT also induced the expression of osteonectin in LNCaP and cyclopamine blocked these expressions in osteonectin, N-cadherin and vimentin (p = 0.0084, 0.0002 and 0.0373, respectively).	cyclopamine	142-153	cadherin 2	Homo sapiens	57-67
25356787-7	2014	Real-time RT-PCR showed whereas both Shh and DHT induced N-cadherin and vimentin, DHT also induced the expression of osteonectin in LNCaP and cyclopamine blocked these expressions in osteonectin, N-cadherin and vimentin (p = 0.0084, 0.0002 and 0.0373, respectively).	cyclopamine	142-153	vimentin	Homo sapiens	72-80
25356787-7	2014	Real-time RT-PCR showed whereas both Shh and DHT induced N-cadherin and vimentin, DHT also induced the expression of osteonectin in LNCaP and cyclopamine blocked these expressions in osteonectin, N-cadherin and vimentin (p = 0.0084, 0.0002 and 0.0373, respectively).	cyclopamine	142-153	cadherin 2	Homo sapiens	196-206
25356787-7	2014	Real-time RT-PCR showed whereas both Shh and DHT induced N-cadherin and vimentin, DHT also induced the expression of osteonectin in LNCaP and cyclopamine blocked these expressions in osteonectin, N-cadherin and vimentin (p = 0.0084, 0.0002 and 0.0373, respectively).	cyclopamine	142-153	vimentin	Homo sapiens	211-219
25373737-6	2014	Furthermore, overexpressed Sufu sensitized glioblastoma to Temozolomide and Cyclopamine.	cyclopamine	76-87	SUFU negative regulator of hedgehog signaling	Homo sapiens	27-31
25281744-0	2014	Cyclopamine modulates gamma-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradation.	cyclopamine	0-11	amyloid beta precursor protein	Homo sapiens	59-84
25623978-12	2014	CONCLUSIONS: The overexpression and cyclopamine inhibition of the Shh signaling pathway are closely related to the content of fluoride in the liver.	cyclopamine	36-47	sonic hedgehog signaling molecule	Rattus norvegicus	66-69
24744439-9	2014	Correspondingly, blockade of Shh signaling by cyclopamine, a small molecule inhibitor of Smoothened, inhibited fibroblast proliferation, reduced myofibroblast accumulation, and attenuated renal fibrosis.	cyclopamine	46-57	sonic hedgehog signaling molecule	Homo sapiens	29-32
25368233-0	2014	Cyclopamine decreased the expression of Sonic Hedgehog and its downstream genes in colon cancer stem cells.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	40-54
25368233-6	2014	The expression of stemness markers, Shh downstream genes and EMT markers were higher in cancer spheres than the parental cell line and down-regulated by cyclopamine treatment in a dose-dependent manner.	cyclopamine	153-164	sonic hedgehog signaling molecule	Homo sapiens	36-39
25368233-7	2014	CONCLUSION: Overall, these findings show that cyclopamine treatment could down-regulate the expression of stemness markers, shh downstream genes and EMT markers on HCT-116 spheres.	cyclopamine	46-57	sonic hedgehog signaling molecule	Homo sapiens	124-127
25378935-0	2014	Gli3 silencing enhances cyclopamine suppressive effects on ovarian cancer.	cyclopamine	24-35	GLI family zinc finger 3	Homo sapiens	0-4
25378935-4	2014	In addition, the silencing of the glioma-associated oncogene (Gli)3, a downstream component of the hedgehog signaling pathway, could further enhance the antitumor effects of cyclopamine.	cyclopamine	174-185	GLI family zinc finger 3	Homo sapiens	34-67
25378935-5	2014	Our results suggest that Gli3 may act as resistance to cyclopamine"s effect on tumor growth.	cyclopamine	55-66	GLI family zinc finger 3	Homo sapiens	25-29
24993635-10	2014	We used cyclopamine, a specific inhibitor of this pathway, to analyze the expression of DZIP1 and its associated mRNAs.	cyclopamine	8-19	DAZ interacting zinc finger protein 1	Homo sapiens	88-93
25034046-8	2014	The effect of cyclopamine (Cpn), a HH signaling inhibitor, on the expression of COL10A1, ALP, OC and COL1A1 was also determined.	cyclopamine	14-25	collagen type X alpha 1 chain	Homo sapiens	80-87
25034046-8	2014	The effect of cyclopamine (Cpn), a HH signaling inhibitor, on the expression of COL10A1, ALP, OC and COL1A1 was also determined.	cyclopamine	14-25	bone gamma-carboxyglutamate protein	Homo sapiens	94-96
25034046-8	2014	The effect of cyclopamine (Cpn), a HH signaling inhibitor, on the expression of COL10A1, ALP, OC and COL1A1 was also determined.	cyclopamine	14-25	collagen type I alpha 1 chain	Homo sapiens	101-107
25034046-8	2014	The effect of cyclopamine (Cpn), a HH signaling inhibitor, on the expression of COL10A1, ALP, OC and COL1A1 was also determined.	cyclopamine	27-30	collagen type X alpha 1 chain	Homo sapiens	80-87
25034046-8	2014	The effect of cyclopamine (Cpn), a HH signaling inhibitor, on the expression of COL10A1, ALP, OC and COL1A1 was also determined.	cyclopamine	27-30	alkaline phosphatase, placental	Homo sapiens	89-92
25034046-8	2014	The effect of cyclopamine (Cpn), a HH signaling inhibitor, on the expression of COL10A1, ALP, OC and COL1A1 was also determined.	cyclopamine	27-30	bone gamma-carboxyglutamate protein	Homo sapiens	94-96
25034046-8	2014	The effect of cyclopamine (Cpn), a HH signaling inhibitor, on the expression of COL10A1, ALP, OC and COL1A1 was also determined.	cyclopamine	27-30	collagen type I alpha 1 chain	Homo sapiens	101-107
25034046-14	2014	Cpn reversed the effect of Npx on the expression of COL10A1, ALP, OPN and COL1A1.	cyclopamine	0-3	collagen type X alpha 1 chain	Homo sapiens	52-59
25034046-14	2014	Cpn reversed the effect of Npx on the expression of COL10A1, ALP, OPN and COL1A1.	cyclopamine	0-3	alkaline phosphatase, placental	Homo sapiens	61-64
25034046-14	2014	Cpn reversed the effect of Npx on the expression of COL10A1, ALP, OPN and COL1A1.	cyclopamine	0-3	secreted phosphoprotein 1	Homo sapiens	66-69
25034046-14	2014	Cpn reversed the effect of Npx on the expression of COL10A1, ALP, OPN and COL1A1.	cyclopamine	0-3	collagen type I alpha 1 chain	Homo sapiens	74-80
24837216-9	2014	Using cyclopamine for 24 h, PTHrP mRNA expression was significantly decreased (-88%, P<0.05), types I and II collagen were decreased (-90% and -82%, P<0.001), and type X collagen was increased (+261%, P<0.001).	cyclopamine	6-17	parathyroid hormone like hormone	Homo sapiens	28-33
24837216-9	2014	Using cyclopamine for 24 h, PTHrP mRNA expression was significantly decreased (-88%, P<0.05), types I and II collagen were decreased (-90% and -82%, P<0.001), and type X collagen was increased (+261%, P<0.001).	cyclopamine	6-17	collagen type X alpha 1 chain	Sus scrofa	169-184
25010521-4	2014	Sox11-deficient zebrafish embryos displayed delayed and abnormal lens formation, coloboma, and a specific reduction in rod photoreceptors, all of which could be rescued by treatment with the Hedgehog pathway inhibitor cyclopamine.	cyclopamine	218-229	SRY-box transcription factor 11	Homo sapiens	0-5
24810957-14	2014	MMP-2 expression was significantly greater in Shh-N-treated eyes than in the control eyes, and was lower in the cyclopamine plus FDM groups than in the FDM group.	cyclopamine	112-123	72 kDa type IV collagenase	Cavia porcellus	0-5
24712566-8	2014	In vitro treatment with cyclopamine resulted in decreased GLI3, SFRP1, and CTNNB1 mRNA expression and beta-catenin staining as well as decreased cell viability.	cyclopamine	24-35	GLI family zinc finger 3	Homo sapiens	58-62
24712566-8	2014	In vitro treatment with cyclopamine resulted in decreased GLI3, SFRP1, and CTNNB1 mRNA expression and beta-catenin staining as well as decreased cell viability.	cyclopamine	24-35	secreted frizzled related protein 1	Homo sapiens	64-69
24712566-8	2014	In vitro treatment with cyclopamine resulted in decreased GLI3, SFRP1, and CTNNB1 mRNA expression and beta-catenin staining as well as decreased cell viability.	cyclopamine	24-35	catenin beta 1	Homo sapiens	75-81
24712566-8	2014	In vitro treatment with cyclopamine resulted in decreased GLI3, SFRP1, and CTNNB1 mRNA expression and beta-catenin staining as well as decreased cell viability.	cyclopamine	24-35	catenin beta 1	Homo sapiens	102-114
24394624-4	2014	We found that T-ALL cells were insensitive to specific Smoothened (SMO) inhibition following the use of low concentrations of the SMO antagonist cyclopamine.	cyclopamine	145-156	smoothened, frizzled class receptor	Homo sapiens	130-133
24653675-5	2014	We observed that SHH increases proliferation of cortical progenitors and generation of astrocytes, whereas blocking SHH signaling with cyclopamine has opposite effects.	cyclopamine	135-146	sonic hedgehog signaling molecule	Homo sapiens	116-119
24765141-4	2014	It was identified that the Shh antagonist, cyclopamine, inhibited cancer proliferation, migration and invasion in a dose- and time-dependent manner.	cyclopamine	43-54	sonic hedgehog signaling molecule	Homo sapiens	27-30
24765141-5	2014	Additionally, it was revealed that several key targets that are activated by the Shh signaling pathway, Gli1 and CXCR4, were downregulated at an RNA and protein level by cyclopamine.	cyclopamine	170-181	sonic hedgehog signaling molecule	Homo sapiens	81-84
24765141-5	2014	Additionally, it was revealed that several key targets that are activated by the Shh signaling pathway, Gli1 and CXCR4, were downregulated at an RNA and protein level by cyclopamine.	cyclopamine	170-181	GLI family zinc finger 1	Homo sapiens	104-108
24765141-5	2014	Additionally, it was revealed that several key targets that are activated by the Shh signaling pathway, Gli1 and CXCR4, were downregulated at an RNA and protein level by cyclopamine.	cyclopamine	170-181	C-X-C motif chemokine receptor 4	Homo sapiens	113-118
24724627-4	2014	TNF-alpha activated Hedgehog (Hh) signaling by enhancing Gli1 nuclear translocation and transcriptional activity, which resulted in increased invasiveness; these effects were blocked by daidzein and the Hh signaling inhibitors, cyclopamine and vismodegib.	cyclopamine	228-239	tumor necrosis factor	Homo sapiens	0-9
24724627-4	2014	TNF-alpha activated Hedgehog (Hh) signaling by enhancing Gli1 nuclear translocation and transcriptional activity, which resulted in increased invasiveness; these effects were blocked by daidzein and the Hh signaling inhibitors, cyclopamine and vismodegib.	cyclopamine	228-239	GLI family zinc finger 1	Homo sapiens	57-61
24804165-3	2014	Here we examined the effects of cyclopamine, a specific inhibitor of the Shh signaling pathway, on cell growth and proliferation in gastric primary cancer cells GAM-016 and the MKN-45 cell line.	cyclopamine	32-43	sonic hedgehog signaling molecule	Homo sapiens	73-76
24608250-4	2014	In contrast to other synthetic small molecule Smo antagonists, the natural product cyclopamine binds to and promotes ciliary accumulation of Smo and "primes" cells for Hh pathway hyper-responsiveness after compound withdrawal.	cyclopamine	83-94	smoothened, frizzled class receptor	Mus musculus	46-49
24608250-4	2014	In contrast to other synthetic small molecule Smo antagonists, the natural product cyclopamine binds to and promotes ciliary accumulation of Smo and "primes" cells for Hh pathway hyper-responsiveness after compound withdrawal.	cyclopamine	83-94	smoothened, frizzled class receptor	Mus musculus	141-144
24608250-6	2014	Like cyclopamine, IPI-926 promoted accumulation of Smo to the PC.	cyclopamine	5-16	smoothened, frizzled class receptor	Mus musculus	51-54
24388991-11	2014	Taken together, our study indicates that the expression of Shh, Smo and Gli1 at the protein and mRNA level in hepatocytes of rats with chronic fluorosis can be increased by fluoride and may be inhibited by cyclopamine and that the Shh signaling pathway plays an important role in the liver pathogenesis caused by fluorosis.	cyclopamine	206-217	sonic hedgehog signaling molecule	Rattus norvegicus	59-62
24388991-11	2014	Taken together, our study indicates that the expression of Shh, Smo and Gli1 at the protein and mRNA level in hepatocytes of rats with chronic fluorosis can be increased by fluoride and may be inhibited by cyclopamine and that the Shh signaling pathway plays an important role in the liver pathogenesis caused by fluorosis.	cyclopamine	206-217	smoothened, frizzled class receptor	Rattus norvegicus	64-67
24388991-11	2014	Taken together, our study indicates that the expression of Shh, Smo and Gli1 at the protein and mRNA level in hepatocytes of rats with chronic fluorosis can be increased by fluoride and may be inhibited by cyclopamine and that the Shh signaling pathway plays an important role in the liver pathogenesis caused by fluorosis.	cyclopamine	206-217	GLI family zinc finger 1	Rattus norvegicus	72-76
24291104-6	2014	In three different assays, Vismodegib and cyclopamine showed lower affinity for the D473H mutant in comparison with wild-type Smo.	cyclopamine	42-53	smoothened, frizzled class receptor	Homo sapiens	126-129
24240054-7	2014	Smo antagonist cyclopamine decreased the proliferation rate of PC12 cells, whereas the overexpression of Stil rescued the cyclopamine-induced decrease in cell proliferation.	cyclopamine	15-26	smoothened, frizzled class receptor	Rattus norvegicus	0-3
24240054-7	2014	Smo antagonist cyclopamine decreased the proliferation rate of PC12 cells, whereas the overexpression of Stil rescued the cyclopamine-induced decrease in cell proliferation.	cyclopamine	122-133	STIL, centriolar assembly protein	Rattus norvegicus	105-109
24738456-3	2014	The inhibitory effects of cyclopamine on the proliferation and apoptosis of the LNCaP cells were detected by MTT and flow cytometry respectively, the morphological changes of the cells observed by Hoechst 33258 staining, and the expression of the PCA3 gene determined by real-time fluorescence quantitative reverse transcriptase polymerase chain reaction (FQ-RT-PCR).	cyclopamine	26-37	prostate cancer associated 3	Homo sapiens	247-251
24738456-8	2014	The cell apoptosis showed a rising trend with the increase of cyclopamine concentration and acting-time, while the expression of the PCA3 gene was decreasing with the increased concentration of cyclopamine, significantly lower than that of the blank control group (P <0.01) , and extremely low in the 10 micromo/L group CONCLUSION: Cyclopamine intervention at 10 and 15 micromol/L for 48 and 72 hours could significantly inhibit the at all time points.	cyclopamine	194-205	prostate cancer associated 3	Homo sapiens	133-137
24738456-8	2014	The cell apoptosis showed a rising trend with the increase of cyclopamine concentration and acting-time, while the expression of the PCA3 gene was decreasing with the increased concentration of cyclopamine, significantly lower than that of the blank control group (P <0.01) , and extremely low in the 10 micromo/L group CONCLUSION: Cyclopamine intervention at 10 and 15 micromol/L for 48 and 72 hours could significantly inhibit the at all time points.	cyclopamine	335-346	prostate cancer associated 3	Homo sapiens	133-137
24741597-6	2014	Cyclopamine (a specific inhibitor of Shh signaling) decreased mRNA expression of Shh, Ptch1, Smo, and Gli1 in cultured RA FLS, Shh, and Smo protein expression, and significantly decreased FLS proliferation.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	136-139
24741597-6	2014	Cyclopamine (a specific inhibitor of Shh signaling) decreased mRNA expression of Shh, Ptch1, Smo, and Gli1 in cultured RA FLS, Shh, and Smo protein expression, and significantly decreased FLS proliferation.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	81-84
24741597-6	2014	Cyclopamine (a specific inhibitor of Shh signaling) decreased mRNA expression of Shh, Ptch1, Smo, and Gli1 in cultured RA FLS, Shh, and Smo protein expression, and significantly decreased FLS proliferation.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	37-40
24367396-0	2013	Cyclopamine analogs bearing exocyclic methylenes are highly potent and acid-stable inhibitors of hedgehog signaling.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	97-105
24741597-6	2014	Cyclopamine (a specific inhibitor of Shh signaling) decreased mRNA expression of Shh, Ptch1, Smo, and Gli1 in cultured RA FLS, Shh, and Smo protein expression, and significantly decreased FLS proliferation.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	81-84
24741597-6	2014	Cyclopamine (a specific inhibitor of Shh signaling) decreased mRNA expression of Shh, Ptch1, Smo, and Gli1 in cultured RA FLS, Shh, and Smo protein expression, and significantly decreased FLS proliferation.	cyclopamine	0-11	patched 1	Homo sapiens	86-91
24741597-6	2014	Cyclopamine (a specific inhibitor of Shh signaling) decreased mRNA expression of Shh, Ptch1, Smo, and Gli1 in cultured RA FLS, Shh, and Smo protein expression, and significantly decreased FLS proliferation.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	93-96
24741597-6	2014	Cyclopamine (a specific inhibitor of Shh signaling) decreased mRNA expression of Shh, Ptch1, Smo, and Gli1 in cultured RA FLS, Shh, and Smo protein expression, and significantly decreased FLS proliferation.	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	102-106
24250231-3	2013	Cyclopamine blocks Hedgehog signaling by antagonizing Smo function, which induces tumor apoptosis.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	54-57
24798568-5	2014	Although the expression level of Gli-1 was markedly downregulated by cyclopamine treatment, treatment with EGCG significantly inhibited the phosphorylation of EGFR in Mia PaCa-2 cells.	cyclopamine	69-80	GLI family zinc finger 1	Homo sapiens	33-38
24119209-6	2013	Shh-treated cultures showed increased neuronal proliferation compared to controls and especially cyclopamine treated cultures, from G93A SOD1 and WT mice.	cyclopamine	97-108	sonic hedgehog	Mus musculus	0-3
23238608-7	2013	We found that the Shh inhibitor cyclopamine in combination with LPS treatment synergistically induced massive cell apoptosis in THP-1 and U937 cells.	cyclopamine	32-43	sonic hedgehog signaling molecule	Homo sapiens	18-21
23928032-2	2013	To investigate its function in postnatal chicken (Gallus gallus) chondrocytes, cyclopamine was used to inhibit Ihh signaling.	cyclopamine	79-90	indian hedgehog	Gallus gallus	111-114
23903906-0	2013	Cyclopamine increases the radiosensitivity of human pancreatic cancer cells by regulating the DNA repair signal pathway through an epidermal growth factor receptor-dependent pathway.	cyclopamine	0-11	epidermal growth factor receptor	Homo sapiens	131-163
23903906-8	2013	Flow cytometry revealed that cyclopamine treatment enhanced gamma-H2AX foci in Colo-357 and SW-1990 cells exposed to irradiation.	cyclopamine	29-40	H2A.X variant histone	Homo sapiens	66-70
23903906-10	2013	EGF also rescued pancreatic cancer cells from cyclopamine-induced H2AX phosphorylation following irradiation.	cyclopamine	46-57	H2A.X variant histone	Homo sapiens	66-70
23903906-11	2013	Thus, cyclopamine enhanced the radiosensitivity of human pancreatic cancer cells, in part, through an EGFR-dependent pathway, indicating a rational approach in combination with radiotherapy.	cyclopamine	6-17	epidermal growth factor receptor	Homo sapiens	102-106
23703673-7	2013	Inhibition of Hh signaling by cyclopamine reduced PLK2, but not PLK1 or PLK3, messenger RNA and protein expression in vehicle-treated and sonic Hh-treated CCA cells, confirming our previous microarray study.	cyclopamine	30-41	polo like kinase 2	Homo sapiens	50-54
23933201-3	2013	We sought to investigate Shh activation in the cortex in the early stage of SAH, and assessed the effect of cyclopamine (a specific inhibitor of the Shh pathway) on Shh pathway regulation and evaluated the impact of cyclopamine on SAH.	cyclopamine	108-119	sonic hedgehog signaling molecule	Rattus norvegicus	149-152
23933201-3	2013	We sought to investigate Shh activation in the cortex in the early stage of SAH, and assessed the effect of cyclopamine (a specific inhibitor of the Shh pathway) on Shh pathway regulation and evaluated the impact of cyclopamine on SAH.	cyclopamine	108-119	sonic hedgehog signaling molecule	Rattus norvegicus	149-152
23499832-4	2013	We found that epidural application of SHH-N substaintially reduced infarct volumes after 7 days of reperfusion, which was reversed by cyclopamine; SHH-N also improved behavioral outcomes as assessed by global neurological functions, rotarod test, and grasping power test.	cyclopamine	134-145	sonic hedgehog signaling molecule	Rattus norvegicus	38-43
23954590-4	2013	We identify the conserved extracellular cysteine-rich domain (CRD) as the site of action for oxysterols on Smo, involving residues structurally analogous to those contacting the Wnt lipid adduct in the homologous Frizzled CRD; this modulatory effect is distinct from that of cyclopamine mimics, from Hh-mediated regulation, and from the permissive action of cellular sterol pools.	cyclopamine	275-286	smoothened, frizzled class receptor	Homo sapiens	107-110
23977364-8	2013	Shh receptor antagonist cyclopamine (10 mg/kg/2 days) during one week.	cyclopamine	24-35	sonic hedgehog	Mus musculus	0-3
23766265-4	2013	Inhibition of Ptc-1 by cyclopamine attenuated low flow-induced increases in Notch expression while concomitantly decreasing human coronary arterial smooth muscle cell growth to that similar under normal flow conditions.	cyclopamine	23-34	patched 1	Homo sapiens	14-19
23238608-7	2013	We found that the Shh inhibitor cyclopamine in combination with LPS treatment synergistically induced massive cell apoptosis in THP-1 and U937 cells.	cyclopamine	32-43	GLI family zinc finger 2	Homo sapiens	128-133
23474492-3	2013	Inhibition of Hedgehog signaling with cyclopamine decreased cell survival and increased phosphorylated beta-catenin without altering myelin protein levels.	cyclopamine	38-49	catenin beta 1	Homo sapiens	103-115
23956832-7	2013	Real-time RT-PCR showed that r-Shh suppressed the expression of E-cadherin and that this suppression was partly blocked by cyclopamine alone in RenCa cells.	cyclopamine	123-134	sonic hedgehog	Mus musculus	31-34
23956832-9	2013	CONCLUSIONS: Shh signaling and EMT play roles in RCC progression, and the Shh signaling inhibitor cyclopamine might be a possible molecular targeted therapeutic strategy for RCC.	cyclopamine	98-109	sonic hedgehog	Mus musculus	74-77
23696546-6	2013	Blockage of the Shh signaling pathway with a pharmacological smoothened inhibitor, cyclopamine, abolished cerebrolysin-induced in vitro neurogenesis and oligodendrogenesis.	cyclopamine	83-94	sonic hedgehog signaling molecule	Rattus norvegicus	16-19
23894369-4	2013	Blockage of Shh with cyclopamine abolishes the effects of Shh on brain edema, BBB permeability and ZO-1, occludin, Ang-1 expression.	cyclopamine	21-32	sonic hedgehog signaling molecule	Homo sapiens	12-15
23894369-4	2013	Blockage of Shh with cyclopamine abolishes the effects of Shh on brain edema, BBB permeability and ZO-1, occludin, Ang-1 expression.	cyclopamine	21-32	sonic hedgehog signaling molecule	Homo sapiens	58-61
23894369-4	2013	Blockage of Shh with cyclopamine abolishes the effects of Shh on brain edema, BBB permeability and ZO-1, occludin, Ang-1 expression.	cyclopamine	21-32	tight junction protein 1	Homo sapiens	99-103
23894369-4	2013	Blockage of Shh with cyclopamine abolishes the effects of Shh on brain edema, BBB permeability and ZO-1, occludin, Ang-1 expression.	cyclopamine	21-32	occludin	Homo sapiens	105-113
23894369-7	2013	Shh also increased ZO-1, occludin and Ang-1 expression in BMECs, while cyclopamine and Ang-1-neutralizing antibody inhibited the effects of Shh on the ZO-1 and occludin expression, respectively.	cyclopamine	71-82	sonic hedgehog signaling molecule	Homo sapiens	140-143
23894369-7	2013	Shh also increased ZO-1, occludin and Ang-1 expression in BMECs, while cyclopamine and Ang-1-neutralizing antibody inhibited the effects of Shh on the ZO-1 and occludin expression, respectively.	cyclopamine	71-82	tight junction protein 1	Homo sapiens	151-155
23894369-7	2013	Shh also increased ZO-1, occludin and Ang-1 expression in BMECs, while cyclopamine and Ang-1-neutralizing antibody inhibited the effects of Shh on the ZO-1 and occludin expression, respectively.	cyclopamine	71-82	occludin	Homo sapiens	160-168
23696546-9	2013	However, in vivo inhibition of the Shh pathway with cyclopamine completely reversed the effects of cerebrolysin on neurorestoration and functional recovery.	cyclopamine	52-63	sonic hedgehog signaling molecule	Rattus norvegicus	35-38
23776550-7	2013	We demonstrate that during late embryogenesis Shh enhances proliferation of NSC, whereas blockage of endogenous Shh signaling using cyclopamine, a potent Hh pathway inhibitor, produces the opposite effect.	cyclopamine	132-143	sonic hedgehog	Mus musculus	112-115
23786654-10	2013	Furthermore, our data demonstrate that hypoxia induced invasion and EMT process are effectively inhibited by Smoothened (SMO) antagonist cyclopamine and GLI1 siRNA.	cyclopamine	137-148	smoothened, frizzled class receptor	Homo sapiens	109-119
23786654-10	2013	Furthermore, our data demonstrate that hypoxia induced invasion and EMT process are effectively inhibited by Smoothened (SMO) antagonist cyclopamine and GLI1 siRNA.	cyclopamine	137-148	smoothened, frizzled class receptor	Homo sapiens	121-124
23786654-11	2013	In addition, GLI1 interference inhibited EMT progress with significantly suppressed vimentin expression, whereas inhibition of SMO through cyclopamine could not reduce vimentin level.	cyclopamine	139-150	smoothened, frizzled class receptor	Homo sapiens	127-130
23357584-0	2013	Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect.	cyclopamine	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	31-36
23325464-4	2013	The proliferation, migration, and tube formation of BMECs cocultured with astrocytes after OGD were significantly enhanced, but cyclopamine (a Shh antagonist) or 5E1 (an antibody of Shh) reversed the change.	cyclopamine	128-139	sonic hedgehog signaling molecule	Homo sapiens	143-146
24029575-4	2013	The cell proliferation was evaluated by Ki-67 staining and BrdU incorporation after treatment by siRNA of Gli2 or shh pathway inhibitor cyclopamine.	cyclopamine	136-147	sonic hedgehog signaling molecule	Homo sapiens	114-117
24029575-5	2013	RESULTS: The results of laser confocal microscopy and Western blot showed that SHH pathway protein which including shh, Patched1 and Gli2 were activated in the PDGF-induced VSMC proliferation.BrdU incorporation assay and Ki-67 staining showed that the cell proliferation which induced by PDGF was inhibited by Gli2-siRNA and cyclopamine which can both block SHH pathway.	cyclopamine	325-336	sonic hedgehog signaling molecule	Homo sapiens	79-82
24029575-5	2013	RESULTS: The results of laser confocal microscopy and Western blot showed that SHH pathway protein which including shh, Patched1 and Gli2 were activated in the PDGF-induced VSMC proliferation.BrdU incorporation assay and Ki-67 staining showed that the cell proliferation which induced by PDGF was inhibited by Gli2-siRNA and cyclopamine which can both block SHH pathway.	cyclopamine	325-336	sonic hedgehog signaling molecule	Homo sapiens	115-118
23336978-10	2013	Exposure of the gpc1 morphants to cyclopamine, a Hedgehog antagonist, partially rescued the gpc1-knockdown phenotype.	cyclopamine	34-45	glypican 1	Homo sapiens	16-20
23336978-10	2013	Exposure of the gpc1 morphants to cyclopamine, a Hedgehog antagonist, partially rescued the gpc1-knockdown phenotype.	cyclopamine	34-45	glypican 1	Homo sapiens	92-96
23511639-8	2013	Intraventricular infusion of Shh and a Shh receptor inhibitor, cyclopamine, to ischemic animals further elevated and suppressed, respectively, miR17-92 cluster expression in the SVZ.	cyclopamine	63-74	sonic hedgehog	Mus musculus	39-42
23511639-8	2013	Intraventricular infusion of Shh and a Shh receptor inhibitor, cyclopamine, to ischemic animals further elevated and suppressed, respectively, miR17-92 cluster expression in the SVZ.	cyclopamine	63-74	Mir17 host gene (non-protein coding)	Mus musculus	143-151
23448715-9	2013	Its effect on cell differentiation is inhibited by Smo antagonists, such as MRT-83, SANT-1, LDE225, and M25 in the nanomolar range, by GDC-0449 in the micromolar range, but not by cyclopamine and CUR61414.	cyclopamine	180-191	smoothened, frizzled class receptor	Homo sapiens	51-54
23508962-8	2013	Interestingly, the SMOH inhibitor cyclopamine was unable to uncouple the effects of OPN on Hh signaling, indicating that OPN nonclassically activates GLI-mediated transcription.	cyclopamine	34-45	smoothened, frizzled class receptor	Homo sapiens	19-23
23357584-9	2013	In addition, cyclopamine induced apoptosis and COX-2 overexpression via PKC activation.	cyclopamine	13-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
23357584-11	2013	Furthermore, we demonstrated that the p38/COX-2 pathway was involved in resistance to cyclopamine-induced apoptosis since p38 inhibition reduced COX-2 overexpression and increased apoptosis in both cell lines.	cyclopamine	86-97	mitogen-activated protein kinase 14	Homo sapiens	38-41
23357584-11	2013	Furthermore, we demonstrated that the p38/COX-2 pathway was involved in resistance to cyclopamine-induced apoptosis since p38 inhibition reduced COX-2 overexpression and increased apoptosis in both cell lines.	cyclopamine	86-97	prostaglandin-endoperoxide synthase 2	Homo sapiens	42-47
23357584-11	2013	Furthermore, we demonstrated that the p38/COX-2 pathway was involved in resistance to cyclopamine-induced apoptosis since p38 inhibition reduced COX-2 overexpression and increased apoptosis in both cell lines.	cyclopamine	86-97	mitogen-activated protein kinase 14	Homo sapiens	122-125
23357584-11	2013	Furthermore, we demonstrated that the p38/COX-2 pathway was involved in resistance to cyclopamine-induced apoptosis since p38 inhibition reduced COX-2 overexpression and increased apoptosis in both cell lines.	cyclopamine	86-97	prostaglandin-endoperoxide synthase 2	Homo sapiens	145-150
23288923-6	2013	Activation of the GLI/Hh signalling in T-LBL promotes cell survival and proliferation, since inhibition of the pathway using short-hairpin-RNA-mediated SMO knockdown, or cyclopamine as a specific antagonist, significantly reduces these cellular processes.	cyclopamine	170-181	GLI family zinc finger 1	Homo sapiens	18-21
23222817-6	2013	Addition of cyclopamine reduced the expression of Sox2 and Bmi1 along with GLI1 and GLI2 expression, induced differentiation and reduced subsphere formation of GICs thereby indicating that hedgehog signaling acts upstream of Sox2 and Bmi1.	cyclopamine	12-23	SRY-box transcription factor 2	Homo sapiens	50-54
23599805-4	2013	Cyclopamine induced a robust G1 cell cycle arrest and elicited notable effects on the expression of cyclin D1 through modulation of the MAPK/ERK signaling pathway.	cyclopamine	0-11	cyclin D1	Homo sapiens	100-109
23599805-5	2013	Cyclopamine also inhibited the invasive ability of both breast cancer cell lines by suppressing the expression levels of NF-kappaB, MMP2 and MMP9 protein.	cyclopamine	0-11	nuclear factor kappa B subunit 1	Homo sapiens	121-130
23599805-5	2013	Cyclopamine also inhibited the invasive ability of both breast cancer cell lines by suppressing the expression levels of NF-kappaB, MMP2 and MMP9 protein.	cyclopamine	0-11	matrix metallopeptidase 2	Homo sapiens	132-136
23599805-5	2013	Cyclopamine also inhibited the invasive ability of both breast cancer cell lines by suppressing the expression levels of NF-kappaB, MMP2 and MMP9 protein.	cyclopamine	0-11	matrix metallopeptidase 9	Homo sapiens	141-145
23599805-6	2013	Furthermore, in estrogen-responsive MCF-7 cells, cyclopamine significantly downregulated the production of estrogen receptor-alpha protein.	cyclopamine	49-60	estrogen receptor 1	Homo sapiens	107-130
24648943-0	2013	Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells.	cyclopamine	29-40	GLI family zinc finger 2	Homo sapiens	73-77
24648943-0	2013	Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells.	cyclopamine	29-40	BCL2 apoptosis regulator	Homo sapiens	82-86
24648943-8	2013	One-way ANOVA test results revealed a significantly greater decrease (P<0.01) of Gli2 and Bcl2 mRNA levels in the cyclopamine-treated group as compared to the blank control group and dimethyl sulfoxide (DMSO)-treated group.	cyclopamine	117-128	GLI family zinc finger 2	Homo sapiens	84-88
24648943-8	2013	One-way ANOVA test results revealed a significantly greater decrease (P<0.01) of Gli2 and Bcl2 mRNA levels in the cyclopamine-treated group as compared to the blank control group and dimethyl sulfoxide (DMSO)-treated group.	cyclopamine	117-128	BCL2 apoptosis regulator	Homo sapiens	93-97
24648943-10	2013	Findings of this study showed that cyclopamine affected the mechanism of HSPA cell apoptosis, which may be associated with the downregulation of Gli2 and Bcl2 mRNA expression levels and the activation of the mitochondrial apoptotic pathways.	cyclopamine	35-46	GLI family zinc finger 2	Homo sapiens	145-149
24648943-10	2013	Findings of this study showed that cyclopamine affected the mechanism of HSPA cell apoptosis, which may be associated with the downregulation of Gli2 and Bcl2 mRNA expression levels and the activation of the mitochondrial apoptotic pathways.	cyclopamine	35-46	BCL2 apoptosis regulator	Homo sapiens	154-158
23264560-9	2013	Cyclopamine was used to inhibit the SHH pathway.	cyclopamine	0-11	sonic hedgehog	Gallus gallus	36-39
23337877-6	2013	Functionally, knockdown of Kindlin-2 cooperates with cyclopamine, a Smoothened antagonist, to decrease the viability of prostate cancer cells.	cyclopamine	53-64	FERM domain containing kindlin 2	Homo sapiens	27-36
23222817-6	2013	Addition of cyclopamine reduced the expression of Sox2 and Bmi1 along with GLI1 and GLI2 expression, induced differentiation and reduced subsphere formation of GICs thereby indicating that hedgehog signaling acts upstream of Sox2 and Bmi1.	cyclopamine	12-23	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	59-63
23222817-6	2013	Addition of cyclopamine reduced the expression of Sox2 and Bmi1 along with GLI1 and GLI2 expression, induced differentiation and reduced subsphere formation of GICs thereby indicating that hedgehog signaling acts upstream of Sox2 and Bmi1.	cyclopamine	12-23	GLI family zinc finger 1	Homo sapiens	75-79
23222817-6	2013	Addition of cyclopamine reduced the expression of Sox2 and Bmi1 along with GLI1 and GLI2 expression, induced differentiation and reduced subsphere formation of GICs thereby indicating that hedgehog signaling acts upstream of Sox2 and Bmi1.	cyclopamine	12-23	GLI family zinc finger 2	Homo sapiens	84-88
23222817-6	2013	Addition of cyclopamine reduced the expression of Sox2 and Bmi1 along with GLI1 and GLI2 expression, induced differentiation and reduced subsphere formation of GICs thereby indicating that hedgehog signaling acts upstream of Sox2 and Bmi1.	cyclopamine	12-23	SRY-box transcription factor 2	Homo sapiens	225-229
23222817-6	2013	Addition of cyclopamine reduced the expression of Sox2 and Bmi1 along with GLI1 and GLI2 expression, induced differentiation and reduced subsphere formation of GICs thereby indicating that hedgehog signaling acts upstream of Sox2 and Bmi1.	cyclopamine	12-23	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	234-238
23714058-3	2013	Cyclopamine was used to block the Shh signaling in SCC-6.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	34-37
23555697-7	2013	Dorsomorphin- and cyclopamine-mediated inhibition of Bmp and Hh signaling, respectively, suggests that proper satb2 expression requires a relatively earlier Bmp signal and a later Hh signal.	cyclopamine	18-29	SATB homeobox 2	Danio rerio	110-115
23077214-3	2013	LgDel embryos treated with cyclopamine, an Shh inhibitor, or carrying mutations in Gli3(Xtj), an Shh-signaling effector, have morphogenetic anomalies that are either not seen, or seen at significantly lower frequencies in control or single-mutant embryos.	cyclopamine	27-38	sonic hedgehog	Mus musculus	43-46
23533494-8	2013	Resveratrol significantly decreased CSC-related Shh expression, Gli-1 nuclear translocation, and cell viability in IL-6-treated HL-60 cells and had synergistic effect with Shh inhibitor cyclopamine on inhibiting cell growth.	cyclopamine	186-197	interleukin 6	Homo sapiens	115-119
23533494-8	2013	Resveratrol significantly decreased CSC-related Shh expression, Gli-1 nuclear translocation, and cell viability in IL-6-treated HL-60 cells and had synergistic effect with Shh inhibitor cyclopamine on inhibiting cell growth.	cyclopamine	186-197	sonic hedgehog signaling molecule	Homo sapiens	172-175
22131072-11	2012	Importantly, KAAD-cyclopamine treatment seemed to inhibit AR activity.	cyclopamine	18-29	androgen receptor	Homo sapiens	58-60
23023870-11	2012	In addition, Shh induced SMC proliferation, which was inhibited not only by AKTI IV but also by cyclopamine, an inhibitor of Shh receptor.	cyclopamine	96-107	sonic hedgehog	Mus musculus	13-16
23023870-11	2012	In addition, Shh induced SMC proliferation, which was inhibited not only by AKTI IV but also by cyclopamine, an inhibitor of Shh receptor.	cyclopamine	96-107	sonic hedgehog	Mus musculus	125-128
22923052-6	2012	After             cyclopamine-mediated blockade of hedgehog, a decrease in proliferation of PANC-1             tumorspheres and G0/G1 transition were observed, as well as a decreased expression             of Bmi-1 in PANC-1 tumorspheres.	cyclopamine	18-29	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	209-214
22923052-7	2012	Cyclopamine reversed chemoresistance to gemcitabine,             resulting in decreased expression of ABCG2 in PANC-1 tumorspheres.	cyclopamine	0-11	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	102-107
22923130-6	2012	Cyclopamine sensitivity most significantly correlated with high             cyclin E (P=0.000009) and low insulin-like growth factor binding protein 6 (IGFBP6)             (P=0.000004) levels.	cyclopamine	0-11	insulin like growth factor binding protein 6	Homo sapiens	106-150
22923130-6	2012	Cyclopamine sensitivity most significantly correlated with high             cyclin E (P=0.000009) and low insulin-like growth factor binding protein 6 (IGFBP6)             (P=0.000004) levels.	cyclopamine	0-11	insulin like growth factor binding protein 6	Homo sapiens	152-158
22923130-8	2012	Cyclopamine             resistance occurred with high GILZ (P=0.002) expression.	cyclopamine	0-11	TSC22 domain family member 3	Homo sapiens	54-58
23063129-6	2012	We show that Smo modulators can uncouple the Smo-Ampk axis from canonical signaling and identify cyclopamine as one of a new class of "selective partial agonists," capable of concomitant inhibition of canonical and activation of noncanonical hedgehog signaling.	cyclopamine	97-108	smoothened, frizzled class receptor	Homo sapiens	13-16
23483902-12	2013	Inhibition of Gli exhibited better cytotoxicity than that of Smo by siRNA and small molecule inhibitors vismodegib and cyclopamine.	cyclopamine	119-130	GLI family zinc finger 1	Homo sapiens	14-17
23483902-12	2013	Inhibition of Gli exhibited better cytotoxicity than that of Smo by siRNA and small molecule inhibitors vismodegib and cyclopamine.	cyclopamine	119-130	smoothened, frizzled class receptor	Homo sapiens	61-64
23268421-2	2012	METHODS: Transwell chamber assay and angiogenesis assay were used to examine the metastatic ability, invasiveness and angiogenesis of EC109 cells treated with cyclopamine for 48 h. The expression of Gli-1 mRNA was detected using RT-PCR, and Western blotting was used to examine the protein expressions of Gli-1, matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF).	cyclopamine	159-170	GLI family zinc finger 1	Homo sapiens	199-204
23268421-4	2012	Cyclopamine treatment significantly lowered the expression of Gli-1 mRNA (P<0.05) and the protein expressions of Gli-1, MMP-9 and VEGF (P<0.05).	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	62-67
23268421-4	2012	Cyclopamine treatment significantly lowered the expression of Gli-1 mRNA (P<0.05) and the protein expressions of Gli-1, MMP-9 and VEGF (P<0.05).	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	116-121
23268421-4	2012	Cyclopamine treatment significantly lowered the expression of Gli-1 mRNA (P<0.05) and the protein expressions of Gli-1, MMP-9 and VEGF (P<0.05).	cyclopamine	0-11	matrix metallopeptidase 9	Homo sapiens	123-128
23268421-4	2012	Cyclopamine treatment significantly lowered the expression of Gli-1 mRNA (P<0.05) and the protein expressions of Gli-1, MMP-9 and VEGF (P<0.05).	cyclopamine	0-11	vascular endothelial growth factor A	Homo sapiens	133-137
23268421-5	2012	CONCLUSION: Cyclopamine can significantly inhibit the metastatic capacity of EC109 cells possibly by down-regulating MMP-9 and VEGF expression as a result of Gli-1 inhibition.	cyclopamine	12-23	matrix metallopeptidase 9	Homo sapiens	117-122
23268421-5	2012	CONCLUSION: Cyclopamine can significantly inhibit the metastatic capacity of EC109 cells possibly by down-regulating MMP-9 and VEGF expression as a result of Gli-1 inhibition.	cyclopamine	12-23	vascular endothelial growth factor A	Homo sapiens	127-131
23268421-5	2012	CONCLUSION: Cyclopamine can significantly inhibit the metastatic capacity of EC109 cells possibly by down-regulating MMP-9 and VEGF expression as a result of Gli-1 inhibition.	cyclopamine	12-23	GLI family zinc finger 1	Homo sapiens	158-163
22797776-6	2012	Cyclopamine treatment decreases Gli1 localization in the nucleus compared to non-treated cells.	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	32-36
22730244-7	2012	Notably, both pharmacological inhibition of HH signaling by the SMOOTHENED (SMO) antagonist cyclopamine and GLI antagonist GANT61 and stable expression of shRNA targeting either SMO or GLI1 result in a significant decrease in melanoma stem cell self-renewal in vitro and a reduction in the number of ALDH(high) melanoma stem cells.	cyclopamine	92-103	smoothened, frizzled class receptor	Homo sapiens	64-74
22488688-10	2012	Furthermore, reduction of GLI2, but not GLI3, decreased the expression of both SOX9 and OPN, whereas overexpressing SOX9 or constitutively active GLI2 could rescue the antagonistic effects of cyclopamine on OPN expression.	cyclopamine	192-203	GLI family zinc finger 2	Homo sapiens	26-30
22488688-10	2012	Furthermore, reduction of GLI2, but not GLI3, decreased the expression of both SOX9 and OPN, whereas overexpressing SOX9 or constitutively active GLI2 could rescue the antagonistic effects of cyclopamine on OPN expression.	cyclopamine	192-203	SRY-box transcription factor 9	Homo sapiens	116-120
22488688-10	2012	Furthermore, reduction of GLI2, but not GLI3, decreased the expression of both SOX9 and OPN, whereas overexpressing SOX9 or constitutively active GLI2 could rescue the antagonistic effects of cyclopamine on OPN expression.	cyclopamine	192-203	GLI family zinc finger 2	Homo sapiens	146-150
22450749-6	2012	Moreover, we also demonstrate that the invasion of a pancreatic cancer and EMT resulting from the activation of SDF-1/CXCR4 axis is effectively inhibited by Smoothened (SMO) inhibitor cyclopamine and siRNA specific to Gli-1.	cyclopamine	184-195	C-X-C motif chemokine ligand 12	Homo sapiens	112-117
22450749-6	2012	Moreover, we also demonstrate that the invasion of a pancreatic cancer and EMT resulting from the activation of SDF-1/CXCR4 axis is effectively inhibited by Smoothened (SMO) inhibitor cyclopamine and siRNA specific to Gli-1.	cyclopamine	184-195	C-X-C motif chemokine receptor 4	Homo sapiens	118-123
22450749-6	2012	Moreover, we also demonstrate that the invasion of a pancreatic cancer and EMT resulting from the activation of SDF-1/CXCR4 axis is effectively inhibited by Smoothened (SMO) inhibitor cyclopamine and siRNA specific to Gli-1.	cyclopamine	184-195	smoothened, frizzled class receptor	Homo sapiens	157-167
22450749-6	2012	Moreover, we also demonstrate that the invasion of a pancreatic cancer and EMT resulting from the activation of SDF-1/CXCR4 axis is effectively inhibited by Smoothened (SMO) inhibitor cyclopamine and siRNA specific to Gli-1.	cyclopamine	184-195	smoothened, frizzled class receptor	Homo sapiens	169-172
22730244-7	2012	Notably, both pharmacological inhibition of HH signaling by the SMOOTHENED (SMO) antagonist cyclopamine and GLI antagonist GANT61 and stable expression of shRNA targeting either SMO or GLI1 result in a significant decrease in melanoma stem cell self-renewal in vitro and a reduction in the number of ALDH(high) melanoma stem cells.	cyclopamine	92-103	smoothened, frizzled class receptor	Homo sapiens	76-79
22773833-9	2012	Cyclopamine-mediated reduction in anoikis resistance was associated with reduced expression of Gli1 and induction of cleaved PARP.	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	95-99
22773833-9	2012	Cyclopamine-mediated reduction in anoikis resistance was associated with reduced expression of Gli1 and induction of cleaved PARP.	cyclopamine	0-11	poly(ADP-ribose) polymerase 1	Homo sapiens	125-129
22773833-10	2012	Shh treatment blocked cyclopamine-induced anoikis.	cyclopamine	22-33	sonic hedgehog signaling molecule	Homo sapiens	0-3
22264144-7	2012	NELL-1 treatment increased Hedgehog signaling pathway expression; coapplication of the Smoothened antagonist Cyclopamine reversed the pro-osteogenic effect of NELL-1.	cyclopamine	109-120	neural EGFL like 1	Homo sapiens	159-165
22849868-4	2012	Current research mainly focuses on the syntheses of the inhibitors of cyclopamine derivatives, which bind specifically to the Smo protein, and can be used for cancer therapy.	cyclopamine	70-81	smoothened, frizzled class receptor	Homo sapiens	126-129
22679015-7	2012	KCOT-1 cells were treated with SMO antagonist cyclopamine.	cyclopamine	46-57	smoothened, frizzled class receptor	Homo sapiens	31-34
22679015-8	2012	We found that cyclopamine significantly arrested the growth of KCOT-1 cells in a dose-dependent manner and that the effects of cyclopamine were abolished by adding SHH protein.	cyclopamine	14-25	sonic hedgehog signaling molecule	Homo sapiens	164-167
22679015-8	2012	We found that cyclopamine significantly arrested the growth of KCOT-1 cells in a dose-dependent manner and that the effects of cyclopamine were abolished by adding SHH protein.	cyclopamine	127-138	sonic hedgehog signaling molecule	Homo sapiens	164-167
22679015-9	2012	The protein expression of the SHH pathway was down-regulated by cyclopamine, further confirming that cyclopamine inhibits the SHH signaling pathway; SHH down-regulation correlated with the down-regulation of the NOTCH signaling pathway as well.	cyclopamine	64-75	sonic hedgehog signaling molecule	Homo sapiens	30-33
22679015-9	2012	The protein expression of the SHH pathway was down-regulated by cyclopamine, further confirming that cyclopamine inhibits the SHH signaling pathway; SHH down-regulation correlated with the down-regulation of the NOTCH signaling pathway as well.	cyclopamine	64-75	sonic hedgehog signaling molecule	Homo sapiens	126-129
22679015-9	2012	The protein expression of the SHH pathway was down-regulated by cyclopamine, further confirming that cyclopamine inhibits the SHH signaling pathway; SHH down-regulation correlated with the down-regulation of the NOTCH signaling pathway as well.	cyclopamine	64-75	sonic hedgehog signaling molecule	Homo sapiens	126-129
22679015-9	2012	The protein expression of the SHH pathway was down-regulated by cyclopamine, further confirming that cyclopamine inhibits the SHH signaling pathway; SHH down-regulation correlated with the down-regulation of the NOTCH signaling pathway as well.	cyclopamine	101-112	sonic hedgehog signaling molecule	Homo sapiens	30-33
22679015-9	2012	The protein expression of the SHH pathway was down-regulated by cyclopamine, further confirming that cyclopamine inhibits the SHH signaling pathway; SHH down-regulation correlated with the down-regulation of the NOTCH signaling pathway as well.	cyclopamine	101-112	sonic hedgehog signaling molecule	Homo sapiens	126-129
22679015-9	2012	The protein expression of the SHH pathway was down-regulated by cyclopamine, further confirming that cyclopamine inhibits the SHH signaling pathway; SHH down-regulation correlated with the down-regulation of the NOTCH signaling pathway as well.	cyclopamine	101-112	sonic hedgehog signaling molecule	Homo sapiens	126-129
22679015-10	2012	In conclusion, using an established KCOT-1 cell population, we characterized the gene expression profiles related to the EMPs, SHH, and NOTCH signaling pathway and confirmed that cyclopamine significantly arrested the growth of KCOT-1 cells and may be a viable agent as a novel therapeutic.	cyclopamine	179-190	sonic hedgehog signaling molecule	Homo sapiens	127-130
22692966-9	2012	The blockage of the Shh signal with the pharmacological inhibitor cyclopamine attenuated EGCG-induced hippocampal neurogenesis.	cyclopamine	66-77	sonic hedgehog	Mus musculus	20-23
22581058-5	2012	Furthermore, EGFR RNAi             significantly enhanced cyclopamine sensitivity both in vitro and in vivo, and             a synergistic decrease of both AKT and ERK phosphorylation was observed.	cyclopamine	58-69	epidermal growth factor receptor	Homo sapiens	13-17
22944238-9	2012	After the blocking of EGFR and Hedgehog signaling pathways by RNAi silencing, the chemosensitivity to cyclopamine significantly increased in human pancreatic cancer cells.	cyclopamine	102-113	epidermal growth factor receptor	Homo sapiens	22-26
22080758-2	2012	Here we characterize the changes in acute myelogenous leukemia (HL-60) cells after blocking the Shh pathway by an antagonist of Smoothened, cyclopamine.	cyclopamine	140-151	sonic hedgehog signaling molecule	Homo sapiens	96-99
22461522-5	2012	Blockade of Shh signaling by cyclopamine (CYC) or of NF-kappaB activation by BAY abolished FD-enhanced EMT and invasion by HCT116 cells.	cyclopamine	29-40	sonic hedgehog signaling molecule	Homo sapiens	12-15
22461522-5	2012	Blockade of Shh signaling by cyclopamine (CYC) or of NF-kappaB activation by BAY abolished FD-enhanced EMT and invasion by HCT116 cells.	cyclopamine	42-45	sonic hedgehog signaling molecule	Homo sapiens	12-15
22469853-14	2012	Conversely, knockdown of Ihh by siRNA and Hh inhibitor cyclopamine had the opposite effect.	cyclopamine	55-66	Indian hedgehog signaling molecule	Homo sapiens	25-28
22080758-4	2012	Treatment with cyclopamine increases the expression of monocytic cell markers CD11b and CD14, but the expression of CD13, CD33 and CD38 is unchanged.	cyclopamine	15-26	integrin subunit alpha M	Homo sapiens	78-83
22080758-4	2012	Treatment with cyclopamine increases the expression of monocytic cell markers CD11b and CD14, but the expression of CD13, CD33 and CD38 is unchanged.	cyclopamine	15-26	CD14 molecule	Homo sapiens	88-92
22080758-5	2012	The monocytic differentiation of HL-60 cells induced by cyclopamine is also evidenced by an increase in Egr-1 expression.	cyclopamine	56-67	early growth response 1	Homo sapiens	104-109
22080758-6	2012	Importantly, cyclopamine down-regulates the phosphorylation of Akt and ERK, but activates AMP-activated protein kinase (AMPK) signaling.	cyclopamine	13-24	AKT serine/threonine kinase 1	Homo sapiens	63-66
22080758-6	2012	Importantly, cyclopamine down-regulates the phosphorylation of Akt and ERK, but activates AMP-activated protein kinase (AMPK) signaling.	cyclopamine	13-24	mitogen-activated protein kinase 1	Homo sapiens	71-74
22302193-6	2012	Blockade of Shh signaling with cyclopamine abolished the Shh-mediated induction of Gli1, Snail1, alpha-SMA, fibronectin, and collagen I.	cyclopamine	31-42	sonic hedgehog	Mus musculus	12-15
22402346-7	2012	Shh also inhibited H2O2-induced apoptosis of astrocytes, and this effect could be partially reversed by cyclopamine.	cyclopamine	104-115	sonic hedgehog signaling molecule	Rattus norvegicus	0-3
22402346-9	2012	Blocking Shh or phosphoinositide 3-kinases (PI3-K)/AKT signaling pathway with cyclopamine or LY294002 decreased the survival rate of astrocytes, induced cell apoptosis, upregulated the expression of Bax, and downregulated the expression of Bcl-2.	cyclopamine	78-89	sonic hedgehog signaling molecule	Rattus norvegicus	9-12
22402346-9	2012	Blocking Shh or phosphoinositide 3-kinases (PI3-K)/AKT signaling pathway with cyclopamine or LY294002 decreased the survival rate of astrocytes, induced cell apoptosis, upregulated the expression of Bax, and downregulated the expression of Bcl-2.	cyclopamine	78-89	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	16-42
22402346-9	2012	Blocking Shh or phosphoinositide 3-kinases (PI3-K)/AKT signaling pathway with cyclopamine or LY294002 decreased the survival rate of astrocytes, induced cell apoptosis, upregulated the expression of Bax, and downregulated the expression of Bcl-2.	cyclopamine	78-89	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
22402346-9	2012	Blocking Shh or phosphoinositide 3-kinases (PI3-K)/AKT signaling pathway with cyclopamine or LY294002 decreased the survival rate of astrocytes, induced cell apoptosis, upregulated the expression of Bax, and downregulated the expression of Bcl-2.	cyclopamine	78-89	BCL2 associated X, apoptosis regulator	Rattus norvegicus	199-202
22402346-9	2012	Blocking Shh or phosphoinositide 3-kinases (PI3-K)/AKT signaling pathway with cyclopamine or LY294002 decreased the survival rate of astrocytes, induced cell apoptosis, upregulated the expression of Bax, and downregulated the expression of Bcl-2.	cyclopamine	78-89	BCL2, apoptosis regulator	Rattus norvegicus	240-245
22406999-8	2012	Analysis of cell viability in the presence of cyclopamine revealed a response of all cell cultures with the exception of one primary culture and one cell line, but only one cell line responded to cyclopamine with reduced hedgehog signaling activity.	cyclopamine	196-207	sonic hedgehog signaling molecule	Homo sapiens	221-229
21979788-4	2012	Accordingly, we established that interference with the Shh pathway (with the Shh antagonist cyclopamine or with miRNA 3245p) sensitized HT22 cells, while augmentation of the Shh pathway (with Shh or the Shh agonist purmorphamine) protected cells against hydrogen peroxide (H2O2) challenge.	cyclopamine	92-103	sonic hedgehog	Mus musculus	55-58
21979788-4	2012	Accordingly, we established that interference with the Shh pathway (with the Shh antagonist cyclopamine or with miRNA 3245p) sensitized HT22 cells, while augmentation of the Shh pathway (with Shh or the Shh agonist purmorphamine) protected cells against hydrogen peroxide (H2O2) challenge.	cyclopamine	92-103	sonic hedgehog	Mus musculus	77-80
21979788-4	2012	Accordingly, we established that interference with the Shh pathway (with the Shh antagonist cyclopamine or with miRNA 3245p) sensitized HT22 cells, while augmentation of the Shh pathway (with Shh or the Shh agonist purmorphamine) protected cells against hydrogen peroxide (H2O2) challenge.	cyclopamine	92-103	sonic hedgehog	Mus musculus	77-80
21979788-4	2012	Accordingly, we established that interference with the Shh pathway (with the Shh antagonist cyclopamine or with miRNA 3245p) sensitized HT22 cells, while augmentation of the Shh pathway (with Shh or the Shh agonist purmorphamine) protected cells against hydrogen peroxide (H2O2) challenge.	cyclopamine	92-103	sonic hedgehog	Mus musculus	77-80
21979788-4	2012	Accordingly, we established that interference with the Shh pathway (with the Shh antagonist cyclopamine or with miRNA 3245p) sensitized HT22 cells, while augmentation of the Shh pathway (with Shh or the Shh agonist purmorphamine) protected cells against hydrogen peroxide (H2O2) challenge.	cyclopamine	92-103	sonic hedgehog	Mus musculus	77-80
22350753-3	2012	Inhibition of SHH signaling by cyclopamine induced apoptosis and blocked proliferation in all major types of NB cells, and abrogated the tumorigenicity of NB cells.	cyclopamine	31-42	sonic hedgehog signaling molecule	Homo sapiens	14-17
22452947-0	2012	Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction.	cyclopamine	52-63	sonic hedgehog signaling molecule	Homo sapiens	27-41
22452947-2	2012	The SHh inhibitor cyclopamine induces apoptosis.	cyclopamine	18-29	sonic hedgehog signaling molecule	Homo sapiens	4-7
22452947-4	2012	Here, we report that cyclopamine mediates ceramide generation selectively via induction of neutral sphingomyelin phosphodiesterase 3, SMPD3 (nSMase2) in Daoy human medulloblastoma cells.	cyclopamine	21-32	sphingomyelin phosphodiesterase 3	Homo sapiens	134-139
22452947-4	2012	Here, we report that cyclopamine mediates ceramide generation selectively via induction of neutral sphingomyelin phosphodiesterase 3, SMPD3 (nSMase2) in Daoy human medulloblastoma cells.	cyclopamine	21-32	sphingomyelin phosphodiesterase 3	Homo sapiens	141-148
22452947-5	2012	Importantly, short interfering RNA-mediated knockdown of nSMase2 prevented cyclopamine-induced ceramide generation and protected Daoy cells from drug-induced apoptosis.	cyclopamine	75-86	sphingomyelin phosphodiesterase 3	Homo sapiens	57-64
22240607-6	2012	Low level of Shh protein was observed in CML bone marrow stromal cells, and CD34(+) progenitor cells are less sensitive to exogenous Shh peptide and more sensitive to cyclopamine than CD34(-) cells (p < 0.05), implying cell-autonomous activation of Shh signaling play a predominant role in progenitor cells.	cyclopamine	167-178	sonic hedgehog signaling molecule	Homo sapiens	13-16
22240607-6	2012	Low level of Shh protein was observed in CML bone marrow stromal cells, and CD34(+) progenitor cells are less sensitive to exogenous Shh peptide and more sensitive to cyclopamine than CD34(-) cells (p < 0.05), implying cell-autonomous activation of Shh signaling play a predominant role in progenitor cells.	cyclopamine	167-178	CD34 molecule	Homo sapiens	76-80
22498944-7	2012	Primary cell culture was developed from the patient"s tissue and showed downregulation of gene expression in response to cyclopamine, a Hh-Gli pathway inhibitor.	cyclopamine	121-132	GLI family zinc finger 1	Homo sapiens	139-142
22452947-8	2012	Mechanistically, our data showed that cyclopamine induced nSMase2 and cell death selectively via increased nitric oxide (NO) generation by neuronal-nitric oxide synthase (n-NOS) induction, in Daoy medulloblastoma, and multiple other human cancer cell lines.	cyclopamine	38-49	sphingomyelin phosphodiesterase 3	Homo sapiens	58-65
22452947-8	2012	Mechanistically, our data showed that cyclopamine induced nSMase2 and cell death selectively via increased nitric oxide (NO) generation by neuronal-nitric oxide synthase (n-NOS) induction, in Daoy medulloblastoma, and multiple other human cancer cell lines.	cyclopamine	38-49	nitric oxide synthase 1	Homo sapiens	139-169
22452947-8	2012	Mechanistically, our data showed that cyclopamine induced nSMase2 and cell death selectively via increased nitric oxide (NO) generation by neuronal-nitric oxide synthase (n-NOS) induction, in Daoy medulloblastoma, and multiple other human cancer cell lines.	cyclopamine	38-49	nitric oxide synthase 1	Homo sapiens	171-176
22452947-9	2012	Knockdown of n-NOS prevented nSMase2 induction and cell death in response to cyclopamine.	cyclopamine	77-88	nitric oxide synthase 1	Homo sapiens	13-18
22452947-9	2012	Knockdown of n-NOS prevented nSMase2 induction and cell death in response to cyclopamine.	cyclopamine	77-88	sphingomyelin phosphodiesterase 3	Homo sapiens	29-36
22452947-11	2012	Thus, our data suggest a novel off-target function of cyclopamine in inducing apoptosis, at least in part, by n-NOS/NO-dependent induction of N-SMase2/ceramide axis, independent of Smo/Gli inhibition.	cyclopamine	54-65	nitric oxide synthase 1	Homo sapiens	110-115
22452947-11	2012	Thus, our data suggest a novel off-target function of cyclopamine in inducing apoptosis, at least in part, by n-NOS/NO-dependent induction of N-SMase2/ceramide axis, independent of Smo/Gli inhibition.	cyclopamine	54-65	sphingomyelin phosphodiesterase 2	Homo sapiens	142-149
22452947-11	2012	Thus, our data suggest a novel off-target function of cyclopamine in inducing apoptosis, at least in part, by n-NOS/NO-dependent induction of N-SMase2/ceramide axis, independent of Smo/Gli inhibition.	cyclopamine	54-65	GLI family zinc finger 1	Homo sapiens	185-188
22302193-6	2012	Blockade of Shh signaling with cyclopamine abolished the Shh-mediated induction of Gli1, Snail1, alpha-SMA, fibronectin, and collagen I.	cyclopamine	31-42	sonic hedgehog	Mus musculus	57-60
22302193-6	2012	Blockade of Shh signaling with cyclopamine abolished the Shh-mediated induction of Gli1, Snail1, alpha-SMA, fibronectin, and collagen I.	cyclopamine	31-42	GLI-Kruppel family member GLI1	Mus musculus	83-87
22302193-6	2012	Blockade of Shh signaling with cyclopamine abolished the Shh-mediated induction of Gli1, Snail1, alpha-SMA, fibronectin, and collagen I.	cyclopamine	31-42	snail family zinc finger 1	Mus musculus	89-95
22302193-6	2012	Blockade of Shh signaling with cyclopamine abolished the Shh-mediated induction of Gli1, Snail1, alpha-SMA, fibronectin, and collagen I.	cyclopamine	31-42	actin alpha 2, smooth muscle, aorta	Mus musculus	97-106
22302193-6	2012	Blockade of Shh signaling with cyclopamine abolished the Shh-mediated induction of Gli1, Snail1, alpha-SMA, fibronectin, and collagen I.	cyclopamine	31-42	fibronectin 1	Mus musculus	108-119
22302193-8	2012	In wild-type mice, cyclopamine did not affect renal Shh expression but did inhibit induction of Gli1, Snail1, and alpha-SMA.	cyclopamine	19-30	GLI-Kruppel family member GLI1	Mus musculus	96-100
22302193-8	2012	In wild-type mice, cyclopamine did not affect renal Shh expression but did inhibit induction of Gli1, Snail1, and alpha-SMA.	cyclopamine	19-30	snail family zinc finger 1	Mus musculus	102-108
22302193-8	2012	In wild-type mice, cyclopamine did not affect renal Shh expression but did inhibit induction of Gli1, Snail1, and alpha-SMA.	cyclopamine	19-30	actin alpha 2, smooth muscle, aorta	Mus musculus	114-123
22204396-8	2012	We monitored the effect of pharmacological modulators of the Hh signaling pathway, purmorphamine-an agonist and cyclopamine-an antagonist of the Smoothened receptor (Smo), on the expression of region-specific transcription factors and signaling molecules relevant for telencephalic development in vivo.	cyclopamine	112-123	smoothened, frizzled class receptor	Homo sapiens	145-164
22204396-8	2012	We monitored the effect of pharmacological modulators of the Hh signaling pathway, purmorphamine-an agonist and cyclopamine-an antagonist of the Smoothened receptor (Smo), on the expression of region-specific transcription factors and signaling molecules relevant for telencephalic development in vivo.	cyclopamine	112-123	smoothened, frizzled class receptor	Homo sapiens	145-148
22265815-2	2012	For both compounds and the positive reference cyclopamine previous reporter gene assays for the transcription factor Gli1 have indicated an inhibition of the hedgehog signaling pathway.	cyclopamine	46-57	GLI family zinc finger 1	Danio rerio	117-121
22241722-7	2012	5-Bromo-2-deoxyuridine labeling and MTT cell proliferation assays revealed that cyclopamine (CP), an inhibitor of the SHH pathway, was able to inhibit the proliferation of KAT-18 and WRO82 cells more effectively than SW1736 cells.	cyclopamine	80-91	sonic hedgehog signaling molecule	Homo sapiens	118-121
21618536-5	2012	Addition of cyclopamine, a Smo inhibitor, reduced Shh- and IGF-I-induced Akt phosphorylation in a similar manner, implying that Shh affects gain of the IGF-I signaling pathway.	cyclopamine	12-23	smoothened, frizzled class receptor	Mus musculus	27-30
21618536-5	2012	Addition of cyclopamine, a Smo inhibitor, reduced Shh- and IGF-I-induced Akt phosphorylation in a similar manner, implying that Shh affects gain of the IGF-I signaling pathway.	cyclopamine	12-23	sonic hedgehog	Mus musculus	50-53
21618536-5	2012	Addition of cyclopamine, a Smo inhibitor, reduced Shh- and IGF-I-induced Akt phosphorylation in a similar manner, implying that Shh affects gain of the IGF-I signaling pathway.	cyclopamine	12-23	insulin-like growth factor 1	Mus musculus	59-64
21618536-5	2012	Addition of cyclopamine, a Smo inhibitor, reduced Shh- and IGF-I-induced Akt phosphorylation in a similar manner, implying that Shh affects gain of the IGF-I signaling pathway.	cyclopamine	12-23	thymoma viral proto-oncogene 1	Mus musculus	73-76
21618536-5	2012	Addition of cyclopamine, a Smo inhibitor, reduced Shh- and IGF-I-induced Akt phosphorylation in a similar manner, implying that Shh affects gain of the IGF-I signaling pathway.	cyclopamine	12-23	sonic hedgehog	Mus musculus	128-131
21618536-5	2012	Addition of cyclopamine, a Smo inhibitor, reduced Shh- and IGF-I-induced Akt phosphorylation in a similar manner, implying that Shh affects gain of the IGF-I signaling pathway.	cyclopamine	12-23	insulin-like growth factor 1	Mus musculus	152-157
22330336-5	2012	The E2-induced enhancement of nerve vascularity was abolished by the Shh inhibitor cyclopamine, and the effect of E2 treatment on Shh, Gli1, and HIP mRNA expression was abolished by the E2 inhibitor ICI.	cyclopamine	83-94	sonic hedgehog	Mus musculus	69-72
22265815-3	2012	In zebrafish embryos a typical phenotype (cyclopia) associated with Shh interference was only observed for cyclopamine.	cyclopamine	107-118	sonic hedgehog signaling molecule a	Danio rerio	68-71
22265815-5	2012	In contrast to these data hspb11 was additionally identified as the most pronounced down-regulated genes for exposure to cyclopamine.	cyclopamine	121-132	heat shock protein, alpha-crystallin-related, b9-like	Danio rerio	26-32
22409914-5	2012	SMO antagonists such as cyclopamine, GDC-0449 and so on show potential to inhibit activity of SHH signaling, and arrest the growth as well as metastases of tumors.	cyclopamine	24-35	smoothened, frizzled class receptor	Homo sapiens	0-3
22409914-5	2012	SMO antagonists such as cyclopamine, GDC-0449 and so on show potential to inhibit activity of SHH signaling, and arrest the growth as well as metastases of tumors.	cyclopamine	24-35	sonic hedgehog signaling molecule	Homo sapiens	94-97
22409914-7	2012	As the classical SMO antagonist, cyclopamine is extracted from a medicinal plant.	cyclopamine	33-44	smoothened, frizzled class receptor	Homo sapiens	17-20
21946948-5	2012	We also evaluated the effects of suppressing the SHh pathway with cyclopamine             and siRNA.	cyclopamine	66-77	sonic hedgehog signaling molecule	Homo sapiens	49-52
21953056-4	2012	In cultured cells, treatment with the Smoothened inhibitor, cyclopamine, reduced miR-25 expression, suggesting Hedgehog signaling stimulates miR-25 production.	cyclopamine	60-71	microRNA 25	Homo sapiens	81-87
21953056-4	2012	In cultured cells, treatment with the Smoothened inhibitor, cyclopamine, reduced miR-25 expression, suggesting Hedgehog signaling stimulates miR-25 production.	cyclopamine	60-71	microRNA 25	Homo sapiens	141-147
22133807-6	2012	Cyclopamine (0.18mg/kg), the classical inhibitor of Shh signaling, was stereotactic injected into the lateral cerebral ventricle immediately after pMCAO.	cyclopamine	0-11	sonic hedgehog signaling molecule	Rattus norvegicus	52-55
22133807-9	2012	Compared with Vehicle group, cyclopamine down-regulated Gli1, Ptch1 and SOD1 in pMCAO-affected brain tissue (P<0.05), and increased infarct volume (P<0.05), brain water content (P<0.05) and behavioral deficits (P<0.05).	cyclopamine	29-40	GLI family zinc finger 1	Rattus norvegicus	56-60
22133807-9	2012	Compared with Vehicle group, cyclopamine down-regulated Gli1, Ptch1 and SOD1 in pMCAO-affected brain tissue (P<0.05), and increased infarct volume (P<0.05), brain water content (P<0.05) and behavioral deficits (P<0.05).	cyclopamine	29-40	patched 1	Rattus norvegicus	62-67
22133807-9	2012	Compared with Vehicle group, cyclopamine down-regulated Gli1, Ptch1 and SOD1 in pMCAO-affected brain tissue (P<0.05), and increased infarct volume (P<0.05), brain water content (P<0.05) and behavioral deficits (P<0.05).	cyclopamine	29-40	superoxide dismutase 1	Rattus norvegicus	72-76
22811598-5	2012	Our findings also show that PTCH-1 receptor expression is decreased upon treatment with HH signaling inhibitors, and receptor binding of 131I-SHH is significantly decreased following treatment with cyclopamine.	cyclopamine	198-209	sonic hedgehog signaling molecule	Homo sapiens	142-145
21946948-8	2012	SHh pathway suppression             with cyclopamine or siRNA inhibited proliferation of extrahepatic biliary tract             cancer cell lines.	cyclopamine	41-52	sonic hedgehog signaling molecule	Homo sapiens	0-3
22500124-6	2012	Discovery of a naturally-occurring Smo inhibitor, cyclopamine, and the identification of Hh pathway mutations and over expression in cancer cells prompted the development of several cyclopamine derivatives.	cyclopamine	182-193	smoothened, frizzled class receptor	Homo sapiens	35-38
22432023-5	2012	Blockage of the Shh pathway with cyclopamine abolished the induction of tube formation and the effect of rhShh on tPA and PAI-1.	cyclopamine	33-44	sonic hedgehog signaling molecule	Homo sapiens	16-19
23028941-9	2012	Gli-1 protein expression increased after Hh agonists and decreased following cyclopamine.	cyclopamine	77-88	GLI family zinc finger 1	Homo sapiens	0-5
23227218-6	2012	By experimentally blocking SHH with cyclopamine, the wild-type single-comb was transformed into a Pea-comb-like phenotype.	cyclopamine	36-47	sonic hedgehog	Gallus gallus	27-30
22432023-5	2012	Blockage of the Shh pathway with cyclopamine abolished the induction of tube formation and the effect of rhShh on tPA and PAI-1.	cyclopamine	33-44	serpin family E member 1	Homo sapiens	122-127
22042246-4	2011	However, in the presence of beta-glucuronidase, the prodrug conducts to the quick release of cyclopamine thereby restoring its antiproliferative activity.	cyclopamine	93-104	glucuronidase beta	Homo sapiens	28-46
22428030-6	2012	Finally, we show that the H460 SP cells preferentially express ABCG2 as well as SMO, a critical mediator of the Hedgehog (HH) signaling, which seems to play an important role in H460 lung cancer cells as its blockage using Cyclopamine greatly inhibits cell-cycle progression.	cyclopamine	223-234	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	63-68
22428030-6	2012	Finally, we show that the H460 SP cells preferentially express ABCG2 as well as SMO, a critical mediator of the Hedgehog (HH) signaling, which seems to play an important role in H460 lung cancer cells as its blockage using Cyclopamine greatly inhibits cell-cycle progression.	cyclopamine	223-234	smoothened, frizzled class receptor	Homo sapiens	80-83
21838786-8	2011	In a xenograft model using immunodeficient mice, the hedgehog signaling inhibitor cyclopamine repressed the tumorigenicity of CD44(+) /CD24(-) cells.	cyclopamine	82-93	CD44 antigen	Mus musculus	126-130
21625222-11	2011	Finally, functional inhibition of ABCG2 drug efflux activity with fumitremorgin C or inhibition of Hh signaling with cyclopamine-KAAD abrogated the stroma-induced chemotolerance suggesting that targeting ABCG2 and Hh signaling may have therapeutic value in overcoming chemoresistance in DLBCL.	cyclopamine	117-128	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	204-209
21838786-8	2011	In a xenograft model using immunodeficient mice, the hedgehog signaling inhibitor cyclopamine repressed the tumorigenicity of CD44(+) /CD24(-) cells.	cyclopamine	82-93	CD24a antigen	Mus musculus	135-139
21838786-9	2011	Our results suggest that this semi-quantitative immunohistochemical analysis is valuable for detecting a small population of cells in cancer tissues and that the hedgehog signaling pathway inhibitor cyclopamine is useful for regulating the CD44(+) /CD24(-) tumor cells in breast cancer.	cyclopamine	199-210	CD44 molecule (Indian blood group)	Homo sapiens	240-244
21838786-9	2011	Our results suggest that this semi-quantitative immunohistochemical analysis is valuable for detecting a small population of cells in cancer tissues and that the hedgehog signaling pathway inhibitor cyclopamine is useful for regulating the CD44(+) /CD24(-) tumor cells in breast cancer.	cyclopamine	199-210	CD24 molecule	Homo sapiens	249-253
21520153-3	2011	METHODS: Shh and its target transcription factor, Gli1 mRNA, were assessed by RT-PCR and/or quantitative RT-PCR in co-cultured cell recombinants comprised of AI C4-2 either with NPF (prostate fibroblasts from normal/benign prostate gland) or CPF (cancer-associated stromal fibroblasts) under Shh/cyclopamine (a hedgehog signaling inhibitor) treatment.	cyclopamine	296-307	sonic hedgehog signaling molecule	Homo sapiens	9-12
22038837-7	2011	Cytoprotection by PDGF-BB was dependent upon Hedgehog (Hh) signaling, because it was abolished by the smoothened (SMO; the transducer of Hh signaling) inhibitor, cyclopamine.	cyclopamine	162-173	smoothened, frizzled class receptor	Homo sapiens	102-112
22038837-7	2011	Cytoprotection by PDGF-BB was dependent upon Hedgehog (Hh) signaling, because it was abolished by the smoothened (SMO; the transducer of Hh signaling) inhibitor, cyclopamine.	cyclopamine	162-173	smoothened, frizzled class receptor	Homo sapiens	114-117
21520153-7	2011	Our study suggests that drugs like cyclopamine that interfere with Shh signaling could be beneficial in preventing AI progression in prostate cancer cells.	cyclopamine	35-46	sonic hedgehog signaling molecule	Homo sapiens	67-70
21803487-4	2011	A decrease of proliferation and tumorigenic potential, as well as increased apoptosis and a dramatic decrease in the percentage of CD15+ cell population were produced upon Hh inhibition by cyclopamine.	cyclopamine	189-200	fucosyltransferase 4	Homo sapiens	131-135
21701772-10	2011	Despite this resistance, inhibition of the Hh pathway with cyclopamine prevented further growth of SFCs with a 10-, 5-, and 4-fold restriction in growth for ES2, SKOV3, and TOV112D, respectively.	cyclopamine	59-70	ess-2 splicing factor homolog	Homo sapiens	157-160
21793033-5	2011	In Huh7.5 cells, we found that cyclopamine, an Hh pathway antagonist, reduced HCV RNA levels by 50% compared with vehicle and inactive isomer controls.	cyclopamine	31-42	MIR7-3 host gene	Homo sapiens	3-7
21829213-5	2011	Inhibiting the Shh signaling pathway with cyclopamine blocked the increase of tPA and the decrease of PAI-1 expression in astrocytes subjected to MSC coculture or recombinant mouse Shh (rm-Shh) treatment.	cyclopamine	42-53	sonic hedgehog	Mus musculus	15-18
21829213-5	2011	Inhibiting the Shh signaling pathway with cyclopamine blocked the increase of tPA and the decrease of PAI-1 expression in astrocytes subjected to MSC coculture or recombinant mouse Shh (rm-Shh) treatment.	cyclopamine	42-53	plasminogen activator, tissue	Mus musculus	78-81
21829213-5	2011	Inhibiting the Shh signaling pathway with cyclopamine blocked the increase of tPA and the decrease of PAI-1 expression in astrocytes subjected to MSC coculture or recombinant mouse Shh (rm-Shh) treatment.	cyclopamine	42-53	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	102-107
21829213-5	2011	Inhibiting the Shh signaling pathway with cyclopamine blocked the increase of tPA and the decrease of PAI-1 expression in astrocytes subjected to MSC coculture or recombinant mouse Shh (rm-Shh) treatment.	cyclopamine	42-53	sonic hedgehog	Mus musculus	181-184
21829213-5	2011	Inhibiting the Shh signaling pathway with cyclopamine blocked the increase of tPA and the decrease of PAI-1 expression in astrocytes subjected to MSC coculture or recombinant mouse Shh (rm-Shh) treatment.	cyclopamine	42-53	sonic hedgehog	Mus musculus	181-184
21829213-6	2011	Both MSCs and rm-Shh decreased the transforming growth factor-beta1 level in astrocytes, and the Shh pathway inhibitor cyclopamine reversed these decreases.	cyclopamine	119-130	sonic hedgehog	Mus musculus	97-100
21906949-8	2011	Intrathecal or peripheral administration of cyclopamine (CP), a specific inhibitor of Sonic Hedgehog signaling, blocked the development of analgesic tolerance to morphine (MS) or morphine antinociception in standard assays of inflammatory pain in rats and synergistically augmented and sustained morphine analgesia in assays of neuropathic pain.	cyclopamine	44-55	hedgehog	Drosophila melanogaster	92-100
21674124-9	2011	Inhibition of SMO by cyclopamine slowed the growth of human rhabdomyosarcoma cell lines.	cyclopamine	21-32	smoothened, frizzled class receptor	Homo sapiens	14-17
21334406-10	2011	Hh activity in Huh-7 CD133(-)/EpCAM(-) cells was higher than in their positive counterparts, and the inhibition of Hh activity by cyclopamine resulted in reduced cell proliferation.	cyclopamine	130-141	prominin 1	Homo sapiens	21-26
21940310-0	2011	Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro.	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	99-103
21940310-4	2011	Moreover, we studied the regulation of Gli1 on insulin-like growth factor binding protein 6 (IGFBP6) and B-cell CLL/lymphoma 2 (Bcl-2) genes at the level of transcription by XChIP and cyclopamine inhibition assay.	cyclopamine	184-195	GLI family zinc finger 1	Homo sapiens	39-43
21498615-7	2011	Sonic hedgehog (Shh) mediated upregulation of Notch1 receptor levels was attenuated after cyclopamine treatment in both cell types.	cyclopamine	90-101	sonic hedgehog signaling molecule	Homo sapiens	0-14
21718593-2	2011	Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	137-147
21718593-2	2011	Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	149-152
21718593-2	2011	Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein.	cyclopamine	0-3	smoothened, frizzled class receptor	Homo sapiens	137-147
21718593-2	2011	Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein.	cyclopamine	0-3	smoothened, frizzled class receptor	Homo sapiens	149-152
21774076-4	2011	In addition, cyclopamine is able to modulate, along with oxysterols and other products, the ABCG2 transporter by increasing Ho342 and mitoxantrone uptake.	cyclopamine	13-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	92-97
21614652-3	2011	Cyclopamine, an Shh inhibitor, suppressed the differentiation of cultured Ad (but not La) cells, suggesting the significance of Shh signaling in promoting adult myogenesis.	cyclopamine	0-11	sonic hedgehog L homeolog	Xenopus laevis	16-19
21614652-3	2011	Cyclopamine, an Shh inhibitor, suppressed the differentiation of cultured Ad (but not La) cells, suggesting the significance of Shh signaling in promoting adult myogenesis.	cyclopamine	0-11	sonic hedgehog L homeolog	Xenopus laevis	128-131
21498615-7	2011	Sonic hedgehog (Shh) mediated upregulation of Notch1 receptor levels was attenuated after cyclopamine treatment in both cell types.	cyclopamine	90-101	sonic hedgehog signaling molecule	Homo sapiens	16-19
21498615-7	2011	Sonic hedgehog (Shh) mediated upregulation of Notch1 receptor levels was attenuated after cyclopamine treatment in both cell types.	cyclopamine	90-101	notch receptor 1	Homo sapiens	46-52
21536478-7	2011	Both cyclopamine and GANT61 effectively inhibited GLI expression, slowed cell growth, promoted G1 arrest, increased apoptosis and inhibited migration of OSCC cells.	cyclopamine	5-16	GLI family zinc finger 1	Homo sapiens	50-53
21592788-3	2011	In two assays (i) the inhibition of the Shh-induced Gli-dependent luciferase activity in Shh-light2 cells, (ii) the inhibition of the SAG-induced differentiation of the mesenchymal C3H10T1/2 cells, desmethylveramiline (1) is an inhibitor in the muM range comparable to cyclopamine.	cyclopamine	269-280	sonic hedgehog	Mus musculus	40-43
21385574-11	2011	Furthermore, inhibition of Shh signaling with cyclopamine stimulated Six1(-/-) lungs to grow and branch in culture.	cyclopamine	46-57	sonic hedgehog signaling molecule	Homo sapiens	27-30
21695114-7	2011	We show that mSmo phosphorylation is induced by its agonists and oncogenic mutations but is blocked by its antagonist cyclopamine, and efficient mSmo phosphorylation depends on the kinesin-II ciliary motor.	cyclopamine	118-129	smoothened, frizzled class receptor	Mus musculus	13-17
21385574-11	2011	Furthermore, inhibition of Shh signaling with cyclopamine stimulated Six1(-/-) lungs to grow and branch in culture.	cyclopamine	46-57	SIX homeobox 1	Homo sapiens	69-73
21209421-4	2011	(Biol Reprod 2009; 80:258-263) found that Gli1, one of the three Gli transcription factors, is present in the fetal testis and that its expression is suppressed by the Hedgehog inhibitor cyclopamine.	cyclopamine	187-198	GLI-Kruppel family member GLI1	Mus musculus	42-46
21630164-9	2011	RESULTS: CD44, CD133 and the expression level of HH members, including Shh, SMO, Gli-1, were found to be highly expressed in gemcitabine-resistant cells, which were significantly down-regulated by cyclopamine treatment.	cyclopamine	197-208	CD44 molecule (Indian blood group)	Homo sapiens	9-13
21630164-9	2011	RESULTS: CD44, CD133 and the expression level of HH members, including Shh, SMO, Gli-1, were found to be highly expressed in gemcitabine-resistant cells, which were significantly down-regulated by cyclopamine treatment.	cyclopamine	197-208	prominin 1	Homo sapiens	15-20
21630164-9	2011	RESULTS: CD44, CD133 and the expression level of HH members, including Shh, SMO, Gli-1, were found to be highly expressed in gemcitabine-resistant cells, which were significantly down-regulated by cyclopamine treatment.	cyclopamine	197-208	sonic hedgehog signaling molecule	Homo sapiens	71-74
21630164-9	2011	RESULTS: CD44, CD133 and the expression level of HH members, including Shh, SMO, Gli-1, were found to be highly expressed in gemcitabine-resistant cells, which were significantly down-regulated by cyclopamine treatment.	cyclopamine	197-208	smoothened, frizzled class receptor	Homo sapiens	76-79
21630164-9	2011	RESULTS: CD44, CD133 and the expression level of HH members, including Shh, SMO, Gli-1, were found to be highly expressed in gemcitabine-resistant cells, which were significantly down-regulated by cyclopamine treatment.	cyclopamine	197-208	GLI family zinc finger 1	Homo sapiens	81-86
21305477-11	2011	Experiments using cyclopamine, a Shh pathway inhibitor, blocked the effects of Shh.	cyclopamine	18-29	sonic hedgehog signaling molecule	Homo sapiens	33-36
20971508-0	2011	Cyclopamine induces eosinophilic differentiation and upregulates CD44 expression in myeloid leukemia cells.	cyclopamine	0-11	CD44 molecule (Indian blood group)	Homo sapiens	65-69
20971508-5	2011	Combined treatment with cyclopamine and a monoclonal antibody to ligate CD44 more than additively induced the differentiation of HL-60 cells.	cyclopamine	24-35	CD44 molecule (Indian blood group)	Homo sapiens	72-76
21177415-4	2011	MRT-83 blocks Hedgehog (Hh) signaling in various assays with an IC50 in the nanomolar range, showing greater potency than the reference Smo antagonist cyclopamine.	cyclopamine	151-162	smoothened, frizzled class receptor	Homo sapiens	136-139
21394208-9	2011	Further analysis revealed that SHH pathway blocked by cyclopamine or 5E1 caused a higher reduction in self-renewing capacity of HGC-27 tumorsphere cells than that of adherent cells.	cyclopamine	54-65	sonic hedgehog signaling molecule	Homo sapiens	31-34
21498710-6	2011	Interestingly, Cy treatment and Qu treatment reduced Notch1 protein and its active fragment in DND-41 cells, which suggests a relationship between Notch signaling and Hedgehog or Wnt signaling.	cyclopamine	15-17	notch receptor 1	Homo sapiens	53-59
21498710-6	2011	Interestingly, Cy treatment and Qu treatment reduced Notch1 protein and its active fragment in DND-41 cells, which suggests a relationship between Notch signaling and Hedgehog or Wnt signaling.	cyclopamine	15-17	notch receptor 1	Homo sapiens	53-58
21498710-7	2011	The addition of Cy or Qu to GSI promoted the decrease of Notch1 activation and expression.	cyclopamine	16-18	notch receptor 1	Homo sapiens	57-63
21305477-11	2011	Experiments using cyclopamine, a Shh pathway inhibitor, blocked the effects of Shh.	cyclopamine	18-29	sonic hedgehog signaling molecule	Homo sapiens	79-82
22110720-10	2011	After GLI1 expression repressed by cyclopamine in mRNA and protein level (down-regulation 88.1+-2.2%, 86.4+-2.2%, respectively), DNMT1 and DNMT3a mRNA and protein level decreased by 91.6%+-2.2% and 83.8+-4.8%, 87.4+-2.7% and 84.4+-1.3%, respectively.	cyclopamine	35-46	GLI family zinc finger 1	Homo sapiens	6-10
21135115-5	2011	In comparison, the classical Smo inhibitor, cyclopamine, induced modest cytotoxicity.	cyclopamine	44-55	smoothened, frizzled class receptor	Homo sapiens	29-32
20967826-11	2011	In cultured HSCs, SAG (an Hh agonist) up-regulated, whereas cyclopamine (an Hh antagonist) repressed OPN expression (P < 0.005).	cyclopamine	60-71	secreted phosphoprotein 1	Mus musculus	101-104
20957337-7	2011	The therapeutic effect of TMZ was enhanced by Notch and SHH pathway pharmacological antagonism with GSI-1 and cyclopamine.	cyclopamine	110-121	sonic hedgehog signaling molecule	Homo sapiens	56-59
21219478-6	2011	Importantly, Shh-dependent function controls neural progenitor cell behavior as sox2-positive cell populations were lost in the OT in the absence of Hh signaling, as evidenced in slow-muscle-omitted (smu) mutants and with timed cyclopamine inhibition.	cyclopamine	228-239	sonic hedgehog signaling molecule a	Danio rerio	13-16
20840857-6	2010	Importantly, the treatment with anti-SHH and anti-HIF1 antibodies or cyclopamine, a specific SMO inhibitor, markedly inhibited the nuclear translocation of GLI1 and cell proliferation in the HPASMCs induced by hypoxia and activation of the SHH pathway.	cyclopamine	69-80	smoothened, frizzled class receptor	Homo sapiens	93-96
21931618-6	2011	Treatment of fibroblasts with cyclopamine, an antagonist of Shh signaling, inhibits Patched expression and reduces BODIPY-cholesterol efflux, while treatment with the Shh pathway agonist SAG enhances Patched protein expression and BODIPY-cholesterol efflux.	cyclopamine	30-41	sonic hedgehog	Mus musculus	60-63
20840857-6	2010	Importantly, the treatment with anti-SHH and anti-HIF1 antibodies or cyclopamine, a specific SMO inhibitor, markedly inhibited the nuclear translocation of GLI1 and cell proliferation in the HPASMCs induced by hypoxia and activation of the SHH pathway.	cyclopamine	69-80	GLI family zinc finger 1	Homo sapiens	156-160
20840857-6	2010	Importantly, the treatment with anti-SHH and anti-HIF1 antibodies or cyclopamine, a specific SMO inhibitor, markedly inhibited the nuclear translocation of GLI1 and cell proliferation in the HPASMCs induced by hypoxia and activation of the SHH pathway.	cyclopamine	69-80	sonic hedgehog signaling molecule	Homo sapiens	240-243
20814245-0	2010	Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer.	cyclopamine	47-58	GLI family zinc finger 3	Homo sapiens	0-4
21154121-2	2010	Initial translational studies conducted using cyclopamine, a small-molecule inhibitor of the Smoothened (SMO) component of the Hedgehog pathway, demonstrated that pharmacological blockade of aberrant Hedgehog signaling has the potential to inhibit tumor initiation, progression and metastatic spread.	cyclopamine	46-57	smoothened, frizzled class receptor	Homo sapiens	93-103
21154121-2	2010	Initial translational studies conducted using cyclopamine, a small-molecule inhibitor of the Smoothened (SMO) component of the Hedgehog pathway, demonstrated that pharmacological blockade of aberrant Hedgehog signaling has the potential to inhibit tumor initiation, progression and metastatic spread.	cyclopamine	46-57	smoothened, frizzled class receptor	Homo sapiens	105-108
20980661-9	2010	Moreover, the inhibitory effect of cyclopamine was reversed by overexpressing ip6k2.	cyclopamine	35-46	inositol hexakisphosphate kinase 2a	Danio rerio	78-83
20814245-10	2010	Regression analysis revealed that GLI3 expression significantly correlated with cyclopamine resistance (r = 0.80; p = 0.0102).	cyclopamine	80-91	GLI family zinc finger 3	Homo sapiens	34-38
20814245-11	2010	Knockdown of GLI3 using siRNAs increased sensitivity to cyclopamine.	cyclopamine	56-67	GLI family zinc finger 3	Homo sapiens	13-17
20814245-14	2010	These data suggest that Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer.	cyclopamine	71-82	GLI family zinc finger 3	Homo sapiens	24-28
21063852-13	2010	In the cyclopamine group, the mRNA and protein expression of Gli1, HIF-1(alpha), VEGF and DLL4 was significantly down-regulated (P<0.05 for each) while the expression of PTCH1 showed no significant changes at the mRNA (P=0.293) and protein level (P=0.304).	cyclopamine	7-18	vascular endothelial growth factor A	Rattus norvegicus	81-85
21063852-13	2010	In the cyclopamine group, the mRNA and protein expression of Gli1, HIF-1(alpha), VEGF and DLL4 was significantly down-regulated (P<0.05 for each) while the expression of PTCH1 showed no significant changes at the mRNA (P=0.293) and protein level (P=0.304).	cyclopamine	7-18	delta like canonical Notch ligand 4	Rattus norvegicus	90-94
21063852-13	2010	In the cyclopamine group, the mRNA and protein expression of Gli1, HIF-1(alpha), VEGF and DLL4 was significantly down-regulated (P<0.05 for each) while the expression of PTCH1 showed no significant changes at the mRNA (P=0.293) and protein level (P=0.304).	cyclopamine	7-18	patched 1	Rattus norvegicus	173-178
20729197-8	2010	In vivo inhibition of enhanced SHH signaling by the smoothened antagonist cyclopamine partially rescued perinatal lethality, lung morphology, and altered gene expression in mutant mice.	cyclopamine	74-85	sonic hedgehog	Mus musculus	31-34
21063852-13	2010	In the cyclopamine group, the mRNA and protein expression of Gli1, HIF-1(alpha), VEGF and DLL4 was significantly down-regulated (P<0.05 for each) while the expression of PTCH1 showed no significant changes at the mRNA (P=0.293) and protein level (P=0.304).	cyclopamine	7-18	GLI family zinc finger 1	Rattus norvegicus	61-65
21063852-13	2010	In the cyclopamine group, the mRNA and protein expression of Gli1, HIF-1(alpha), VEGF and DLL4 was significantly down-regulated (P<0.05 for each) while the expression of PTCH1 showed no significant changes at the mRNA (P=0.293) and protein level (P=0.304).	cyclopamine	7-18	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	67-79
20580927-8	2010	The rEPO-dependent neuroprotection was suppressed by the SHH inhibitor cyclopamine (CPM); however, sEPO-R failed to affect SHH neuroprotection.	cyclopamine	71-82	erythropoietin	Rattus norvegicus	4-8
21063852-16	2010	It was concluded that intravitreal administration of cyclopamine can effectively inhibit the formation of laser-induced experimental CNV by down-regulating the expression of the HIF-1(alpha)-VEGF-DLL4 cascade in CNV.	cyclopamine	53-64	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	178-189
21063852-16	2010	It was concluded that intravitreal administration of cyclopamine can effectively inhibit the formation of laser-induced experimental CNV by down-regulating the expression of the HIF-1(alpha)-VEGF-DLL4 cascade in CNV.	cyclopamine	53-64	vascular endothelial growth factor A	Rattus norvegicus	191-195
21063852-16	2010	It was concluded that intravitreal administration of cyclopamine can effectively inhibit the formation of laser-induced experimental CNV by down-regulating the expression of the HIF-1(alpha)-VEGF-DLL4 cascade in CNV.	cyclopamine	53-64	delta like canonical Notch ligand 4	Rattus norvegicus	196-200
20580927-8	2010	The rEPO-dependent neuroprotection was suppressed by the SHH inhibitor cyclopamine (CPM); however, sEPO-R failed to affect SHH neuroprotection.	cyclopamine	71-82	sonic hedgehog signaling molecule	Rattus norvegicus	57-60
20580927-8	2010	The rEPO-dependent neuroprotection was suppressed by the SHH inhibitor cyclopamine (CPM); however, sEPO-R failed to affect SHH neuroprotection.	cyclopamine	84-87	erythropoietin	Rattus norvegicus	4-8
20580927-8	2010	The rEPO-dependent neuroprotection was suppressed by the SHH inhibitor cyclopamine (CPM); however, sEPO-R failed to affect SHH neuroprotection.	cyclopamine	84-87	sonic hedgehog signaling molecule	Rattus norvegicus	57-60
20720195-5	2010	Inhibition of Shh signaling in hVSMCs through treatment with cyclopamine or knockdown of Gli2 results in G(1) arrest and reduced cyclin D1, cyclin E, and phosphorylated retinoblastoma (pRB) levels.	cyclopamine	61-72	sonic hedgehog signaling molecule	Homo sapiens	14-17
20480407-0	2010	CD133+ cells from medulloblastoma and PNET cell lines are more resistant to cyclopamine inhibition of the sonic hedgehog signaling pathway than CD133- cells.	cyclopamine	76-87	prominin 1	Homo sapiens	0-5
20480407-0	2010	CD133+ cells from medulloblastoma and PNET cell lines are more resistant to cyclopamine inhibition of the sonic hedgehog signaling pathway than CD133- cells.	cyclopamine	76-87	sonic hedgehog signaling molecule	Homo sapiens	106-120
20480407-4	2010	Cyclopamine inhibits the SHH pathway in medulloblastoma cell lines, but its effect on cPNET and pPNET cell lines has not been well established yet.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	25-28
20480407-8	2010	Nevertheless, CD133 expression made the cells more resistant to cyclopamine inhibition.	cyclopamine	64-75	prominin 1	Homo sapiens	14-19
20856928-6	2010	MPs(Shh+)-mediated effects on flow recovery and NO production were completely prevented when Shh signalling was inhibited by cyclopamine.	cyclopamine	125-136	sonic hedgehog	Mus musculus	0-9
20856928-6	2010	MPs(Shh+)-mediated effects on flow recovery and NO production were completely prevented when Shh signalling was inhibited by cyclopamine.	cyclopamine	125-136	sonic hedgehog	Mus musculus	4-7
20856928-7	2010	In aorta, MPs(Shh+) increased activation of eNOS/Akt pathway, and VEGF expression, being inhibited by cyclopamine.	cyclopamine	102-113	sonic hedgehog	Mus musculus	10-19
20856928-7	2010	In aorta, MPs(Shh+) increased activation of eNOS/Akt pathway, and VEGF expression, being inhibited by cyclopamine.	cyclopamine	102-113	vascular endothelial growth factor A	Mus musculus	66-70
20856928-8	2010	By contrast, in muscles, MPs(Shh+) enhanced eNOS expression and phosphorylation and decreased caveolin-1 expression, but cyclopamine prevented only the effects of MPs(Shh+) on eNOS pathway.	cyclopamine	121-132	sonic hedgehog	Mus musculus	163-172
20576618-7	2010	Furthermore, inhibition of the hedgehog pathway activation using cyclopamine was sufficient to essentially overcome this chondrogenic defect in both micromass and ex vivo explant assays of Prx1-Cre:Ptc1(c/c) limbs.	cyclopamine	65-76	paired related homeobox 1	Mus musculus	189-193
20576618-7	2010	Furthermore, inhibition of the hedgehog pathway activation using cyclopamine was sufficient to essentially overcome this chondrogenic defect in both micromass and ex vivo explant assays of Prx1-Cre:Ptc1(c/c) limbs.	cyclopamine	65-76	patched 1	Mus musculus	198-202
20720195-5	2010	Inhibition of Shh signaling in hVSMCs through treatment with cyclopamine or knockdown of Gli2 results in G(1) arrest and reduced cyclin D1, cyclin E, and phosphorylated retinoblastoma (pRB) levels.	cyclopamine	61-72	cyclin D1	Homo sapiens	129-138
20720195-5	2010	Inhibition of Shh signaling in hVSMCs through treatment with cyclopamine or knockdown of Gli2 results in G(1) arrest and reduced cyclin D1, cyclin E, and phosphorylated retinoblastoma (pRB) levels.	cyclopamine	61-72	RB transcriptional corepressor 1	Homo sapiens	185-188
20451654-9	2010	Erk1/2 activation was observed in cells where Smo activity had been inhibited using cyclopamine and in the breast epithelial cell line, MCF10A, that does not express Smo.	cyclopamine	84-95	mitogen-activated protein kinase 3	Homo sapiens	0-6
20451654-9	2010	Erk1/2 activation was observed in cells where Smo activity had been inhibited using cyclopamine and in the breast epithelial cell line, MCF10A, that does not express Smo.	cyclopamine	84-95	smoothened, frizzled class receptor	Homo sapiens	46-49
20851287-0	2010	Expression of sonic hedgehog signaling components in hepatocellular carcinoma and cyclopamine-induced apoptosis through Bcl-2 downregulation in vitro.	cyclopamine	82-93	sonic hedgehog signaling molecule	Homo sapiens	14-28
20807782-4	2010	We induced medulloblastomas by retrovirus-mediated expression of Shh and HGF, after which we treated the mice systemically with (a) HGF-neutralizing monoclonal antibody L2G7, (b) Shh signaling inhibitor cyclopamine, (c) Shh-neutralizing monoclonal antibody 5E1, (d) L2G7 + cyclopamine, or (e) L2G7 + 5E1.	cyclopamine	203-214	sonic hedgehog	Mus musculus	179-182
20807782-4	2010	We induced medulloblastomas by retrovirus-mediated expression of Shh and HGF, after which we treated the mice systemically with (a) HGF-neutralizing monoclonal antibody L2G7, (b) Shh signaling inhibitor cyclopamine, (c) Shh-neutralizing monoclonal antibody 5E1, (d) L2G7 + cyclopamine, or (e) L2G7 + 5E1.	cyclopamine	203-214	sonic hedgehog	Mus musculus	179-182
20807782-4	2010	We induced medulloblastomas by retrovirus-mediated expression of Shh and HGF, after which we treated the mice systemically with (a) HGF-neutralizing monoclonal antibody L2G7, (b) Shh signaling inhibitor cyclopamine, (c) Shh-neutralizing monoclonal antibody 5E1, (d) L2G7 + cyclopamine, or (e) L2G7 + 5E1.	cyclopamine	273-284	sonic hedgehog	Mus musculus	179-182
20807782-4	2010	We induced medulloblastomas by retrovirus-mediated expression of Shh and HGF, after which we treated the mice systemically with (a) HGF-neutralizing monoclonal antibody L2G7, (b) Shh signaling inhibitor cyclopamine, (c) Shh-neutralizing monoclonal antibody 5E1, (d) L2G7 + cyclopamine, or (e) L2G7 + 5E1.	cyclopamine	273-284	sonic hedgehog	Mus musculus	179-182
20564213-8	2010	Treatment with the hedgehog inhibitor cyclopamine, which blocks smoothened signaling, increased the activity of the promoter and expression of mature mir-29b.	cyclopamine	38-49	microRNA 29b-1	Homo sapiens	150-157
20851287-0	2010	Expression of sonic hedgehog signaling components in hepatocellular carcinoma and cyclopamine-induced apoptosis through Bcl-2 downregulation in vitro.	cyclopamine	82-93	BCL2 apoptosis regulator	Homo sapiens	120-125
20851287-3	2010	Cyclopamine, an important inhibitor of Shh signaling pathway, can induce cell apoptosis.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	39-42
20851287-5	2010	The aim of this study is to determine the expression of the Shh signaling pathway components in HCC and to investigate the mechanisms underlying cyclopamine-induced apoptosis in HCC cells.	cyclopamine	145-156	sonic hedgehog signaling molecule	Homo sapiens	60-63
20851287-13	2010	Cyclopamine remarkably decreased cell viability, induced apoptosis and downregulated Bcl-2 expression in HCC cells.	cyclopamine	0-11	BCL2 apoptosis regulator	Homo sapiens	85-90
20851287-15	2010	Cyclopamine induces apoptosis through downregulating Bcl-2 in HCC.	cyclopamine	0-11	BCL2 apoptosis regulator	Homo sapiens	53-58
20503376-5	2010	Interestingly, cells expressing mMYH(emb1) were localized together with engrailed, and cyclopamine, which blocks hedgehog signaling, inhibited mMYH(emb1) expression as well as the formation of the horizontal myoseptum, suggesting that muscle pioneer cells express mMYH(emb1) as a key protein in the formation of the horizontal myoseptum.	cyclopamine	87-98	mutY DNA glycosylase	Mus musculus	32-36
20024601-8	2010	Additionally, cyclopamine was used to inhibit the HH signaling activity as an indirect approach to decrease Gli1 expression, and we observed that cyclopamine exclusively inhibited cell growth in HH-pathway-active glioma cell lines.	cyclopamine	146-157	GLI family zinc finger 1	Homo sapiens	108-112
20503376-5	2010	Interestingly, cells expressing mMYH(emb1) were localized together with engrailed, and cyclopamine, which blocks hedgehog signaling, inhibited mMYH(emb1) expression as well as the formation of the horizontal myoseptum, suggesting that muscle pioneer cells express mMYH(emb1) as a key protein in the formation of the horizontal myoseptum.	cyclopamine	87-98	mutY DNA glycosylase	Mus musculus	143-147
20503376-5	2010	Interestingly, cells expressing mMYH(emb1) were localized together with engrailed, and cyclopamine, which blocks hedgehog signaling, inhibited mMYH(emb1) expression as well as the formation of the horizontal myoseptum, suggesting that muscle pioneer cells express mMYH(emb1) as a key protein in the formation of the horizontal myoseptum.	cyclopamine	87-98	mutY DNA glycosylase	Mus musculus	143-147
24855550-3	2010	METHODS AND RESULTS: Using potent antagonists gamma-secretase inhibitor and cyclopamine, we inhibited Notch and Hh pathways, respectively, in the CLS1 hESC line expanded continuously in a hypoxic atmosphere of 5% oxygen.	cyclopamine	76-87	cardiolipin synthase 1	Homo sapiens	146-150
20556567-10	2010	Cyclopamine decreased the survival rate of the three cell lines while Shh increased it, and the inhibition effects of cyclopamine could be partially reversed by shh pre-treatment.	cyclopamine	118-129	sonic hedgehog signaling molecule	Homo sapiens	161-164
20556567-11	2010	Cyclopamine induced the cell apoptosis and the cell cycle arrest in G0/G1 phase, while Shh induced the reverse effects and could partially prevent effects of cyclopamine.	cyclopamine	158-169	sonic hedgehog signaling molecule	Homo sapiens	87-90
20013819-3	2010	Cyclopamine exerted a potent inhibitory effect against the growth of PANC-1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg-1, respectively.	cyclopamine	0-11	pancreas protein 1	Mus musculus	69-75
20501387-8	2010	CONCLUSION: The combined use of cyclopamine and hydroxycamptothecin significantly down-regulates the expression on of bcl-2 to induce the apoptosis of human OSCC cell line HSQ-89.	cyclopamine	32-43	BCL2 apoptosis regulator	Homo sapiens	118-123
19839776-4	2010	Similar observations were made when M2 cells were treated with sonic hedgehog (Shh), and the specific Hh pathway inhibitor cyclopamine blocked 20S-induced Notch target gene expression.	cyclopamine	123-134	sonic hedgehog	Mus musculus	79-82
20025076-8	2010	Importantly, the resistant cells that exhibited no decrease in the levels of Shh and Bcl-2, were sensitized to curcumin by the addition of the Shh antagonist, cyclopamine.	cyclopamine	159-170	sonic hedgehog signaling molecule	Homo sapiens	143-146
19779961-9	2010	Cyclopamine, a specific inhibitor of Hh signaling, reduced the expression of stathmin1 in prostate cancer cells.	cyclopamine	0-11	stathmin 1	Mus musculus	77-86
20098680-7	2010	Cyclopamine administration attenuated Hh signaling in the stroma rather than in the cancer cells as reflected by decreased expression of full length Gli2 protein and Gli1 mRNA specifically in the compartment.	cyclopamine	0-11	GLI family zinc finger 2	Homo sapiens	149-153
20179163-1	2010	The present study has been undertaken to establish the therapeutic benefit of cotargeting epidermal growth factor receptor (EGFR) and sonic hedgehog pathways by using gefitinib and cyclopamine, respectively, for improving the efficacy of the current chemotherapeutic drug docetaxel to counteract the prostate cancer progression from locally invasive to metastatic and recurrent disease stages.	cyclopamine	181-192	epidermal growth factor receptor	Homo sapiens	90-122
20179163-1	2010	The present study has been undertaken to establish the therapeutic benefit of cotargeting epidermal growth factor receptor (EGFR) and sonic hedgehog pathways by using gefitinib and cyclopamine, respectively, for improving the efficacy of the current chemotherapeutic drug docetaxel to counteract the prostate cancer progression from locally invasive to metastatic and recurrent disease stages.	cyclopamine	181-192	epidermal growth factor receptor	Homo sapiens	124-128
20098680-7	2010	Cyclopamine administration attenuated Hh signaling in the stroma rather than in the cancer cells as reflected by decreased expression of full length Gli2 protein and Gli1 mRNA specifically in the compartment.	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	166-170
20098680-9	2010	Host-derived Ang-1 and IGF-1 mRNA levels were downregulated by cyclopamine in the tumor xenografts.	cyclopamine	63-74	angiopoietin 1	Homo sapiens	13-18
20098680-9	2010	Host-derived Ang-1 and IGF-1 mRNA levels were downregulated by cyclopamine in the tumor xenografts.	cyclopamine	63-74	insulin like growth factor 1	Homo sapiens	23-28
19815628-9	2009	Cyclopamine reverted myofibroblastic transition, reducing mesenchymal gene expression while increasing epithelial markers in rodent and human HSC.	cyclopamine	0-11	fucosyltransferase 1 (H blood group)	Homo sapiens	142-145
20067614-10	2010	Inhibition of SMO by cyclopamine, a specific inhibitor of SMO, slowed the growth of osteosarcoma in vitro.	cyclopamine	21-32	smoothened, frizzled class receptor	Homo sapiens	14-17
20067614-10	2010	Inhibition of SMO by cyclopamine, a specific inhibitor of SMO, slowed the growth of osteosarcoma in vitro.	cyclopamine	21-32	smoothened, frizzled class receptor	Homo sapiens	58-61
20067614-12	2010	Cyclopamine reduced the expression of accelerators of the cell cycle including cyclin D1, cyclin E1, SKP2, and pRb.	cyclopamine	0-11	cyclin D1	Homo sapiens	79-88
20067614-12	2010	Cyclopamine reduced the expression of accelerators of the cell cycle including cyclin D1, cyclin E1, SKP2, and pRb.	cyclopamine	0-11	cyclin E1	Homo sapiens	90-99
20067614-12	2010	Cyclopamine reduced the expression of accelerators of the cell cycle including cyclin D1, cyclin E1, SKP2, and pRb.	cyclopamine	0-11	S-phase kinase associated protein 2	Homo sapiens	101-105
20067614-12	2010	Cyclopamine reduced the expression of accelerators of the cell cycle including cyclin D1, cyclin E1, SKP2, and pRb.	cyclopamine	0-11	RB transcriptional corepressor 1	Homo sapiens	111-114
20067614-13	2010	On the other hand, p21(cip1) wprotein was up-regulated by cyclopamine treatment.	cyclopamine	58-69	cyclin dependent kinase inhibitor 1A	Homo sapiens	19-22
20067614-13	2010	On the other hand, p21(cip1) wprotein was up-regulated by cyclopamine treatment.	cyclopamine	58-69	cyclin dependent kinase inhibitor 1A	Homo sapiens	23-27
20024066-5	2010	Shh-signaling antagonists that bind to Smo include cyclopamine, SANT1, and Cur-61414.	cyclopamine	51-62	sonic hedgehog signaling molecule	Homo sapiens	0-3
20024066-5	2010	Shh-signaling antagonists that bind to Smo include cyclopamine, SANT1, and Cur-61414.	cyclopamine	51-62	smoothened, frizzled class receptor	Homo sapiens	39-42
19788370-7	2010	Results were verified for Shh by using perturbation agents such as cyclopamine to show that Shh is indeed one of the active agents in PA6-CM, and by showing that Shh and FGF8 can substitute for PA6-CM at the NSC induction stage.	cyclopamine	67-78	sonic hedgehog signaling molecule	Homo sapiens	26-29
20015350-7	2009	The inhibition of the SHH signaling pathway by the specific inhibitor cyclopamine abolished CRCC cell growth as assessed by cell counting, BrdU incorporation studies, fluorescence-activated cell sorting and beta-galactosidase staining.	cyclopamine	70-81	sonic hedgehog signaling molecule	Homo sapiens	22-25
19412740-5	2009	In addition, treatment with cyclopamine is able to enhance and prolong the survival rates and survival durations of Tg(k18:shh:RFP) embryos.	cyclopamine	28-39	tripartite motif containing 27	Homo sapiens	127-130
19559697-7	2009	In the culture of Dlk(+) hepatoblasts isolated from the E11.5 liver, activation of Hh signaling stimulated their proliferation and this effect was cancelled by a chemical Hh signaling inhibitor, cyclopamine.	cyclopamine	195-206	mitogen-activated protein kinase kinase kinase 12	Mus musculus	18-21
19622100-5	2009	Inhibition of SHH signaling by cyclopamine induced apoptosis and blocked proliferation in all major types of neuroblastoma cells, and abrogated the tumorigenicity of neuroblastoma cells.	cyclopamine	31-42	sonic hedgehog signaling molecule	Homo sapiens	14-17
20032413-5	2009	Cyclopamine decreased the level of Gli1 protein, a target gene product of Hh signaling.	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	35-39
19232458-4	2009	Among the HH inhibitors, cyclopamine inhibits HH signaling through direct interaction with SMOH and retards the growth of cancer cells by inhibiting stem cells.	cyclopamine	25-36	smoothened, frizzled class receptor	Homo sapiens	91-95
19742123-6	2009	Cyclopamine treatment induced cytochrome c release from mitochondria and cleavage of caspase 9.	cyclopamine	0-11	cytochrome c, somatic	Homo sapiens	30-42
19556240-5	2009	We have observed that OPN expression is stimulated in the presence of Hh ligands and inhibited in the presence of the Smoothened (SMO) inhibitor, cyclopamine.	cyclopamine	146-157	secreted phosphoprotein 1	Mus musculus	22-25
19556240-5	2009	We have observed that OPN expression is stimulated in the presence of Hh ligands and inhibited in the presence of the Smoothened (SMO) inhibitor, cyclopamine.	cyclopamine	146-157	smoothened, frizzled class receptor	Mus musculus	118-128
19556240-5	2009	We have observed that OPN expression is stimulated in the presence of Hh ligands and inhibited in the presence of the Smoothened (SMO) inhibitor, cyclopamine.	cyclopamine	146-157	smoothened, frizzled class receptor	Mus musculus	130-133
19742123-7	2009	Moreover, Bcl-2 expression was significantly reduced by cyclopamine treatment.	cyclopamine	56-67	BCL2 apoptosis regulator	Homo sapiens	10-15
19654211-4	2009	Knockdown of the primary cilium by Ift88 and Ift20 siRNA or treatment with cyclopamine, an inhibitor of Smoothened, blocks hedgehog signaling in P19.CL6 cells, as well as differentiation of the cells into beating cardiomyocytes.	cyclopamine	75-86	smoothened, frizzled class receptor	Mus musculus	104-114
19692604-6	2009	Inhibition of the SHH pathway with cyclopamine blocks the Gli response and significantly reduces both the proliferating and overall number of Olig2(+) cells in the injured cortex.	cyclopamine	35-46	sonic hedgehog signaling molecule	Homo sapiens	18-21
19692604-6	2009	Inhibition of the SHH pathway with cyclopamine blocks the Gli response and significantly reduces both the proliferating and overall number of Olig2(+) cells in the injured cortex.	cyclopamine	35-46	GLI family zinc finger 1	Homo sapiens	58-61
19692604-6	2009	Inhibition of the SHH pathway with cyclopamine blocks the Gli response and significantly reduces both the proliferating and overall number of Olig2(+) cells in the injured cortex.	cyclopamine	35-46	oligodendrocyte transcription factor 2	Homo sapiens	142-147
19531636-6	2009	The effects of SHH on wound healing and cutaneous NO function were markedly inhibited by SHH receptor inhibitor cyclopamine.	cyclopamine	112-123	sonic hedgehog	Mus musculus	15-18
19531636-6	2009	The effects of SHH on wound healing and cutaneous NO function were markedly inhibited by SHH receptor inhibitor cyclopamine.	cyclopamine	112-123	sonic hedgehog	Mus musculus	89-92
19531636-7	2009	After 24-h treatment in vitro, SHH (5-20 microg/ml) significantly increased cutaneous endothelial NOS protein expression, NOS activity and NO level in normal mice and STZ-induced diabetic mice in a concentration-dependent manner, an effect that was blunted by cyclopamine and NOS inhibitor N(omega)-nitro-L-arginine methyl ester.	cyclopamine	260-271	sonic hedgehog	Mus musculus	31-34
19422804-6	2009	BDNF protection against 3-NP was abolished by cyclopamine (CPM; 5 microM), the SHH pathway inhibitor.	cyclopamine	46-57	brain-derived neurotrophic factor	Rattus norvegicus	0-4
19422804-6	2009	BDNF protection against 3-NP was abolished by cyclopamine (CPM; 5 microM), the SHH pathway inhibitor.	cyclopamine	46-57	sonic hedgehog signaling molecule	Rattus norvegicus	79-82
19552464-0	2009	Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine.	cyclopamine	79-90	sonic hedgehog signaling molecule	Homo sapiens	38-46
19552464-1	2009	The synthesis and biological evaluation of structurally simplified, metabolically stable cyclopamine-like Sonic Hedgehog (SHH) signaling inhibitors, i.e., 5, is described in four chemical steps from commercially available steroidal precursors.	cyclopamine	89-100	sonic hedgehog signaling molecule	Homo sapiens	106-120
19552464-1	2009	The synthesis and biological evaluation of structurally simplified, metabolically stable cyclopamine-like Sonic Hedgehog (SHH) signaling inhibitors, i.e., 5, is described in four chemical steps from commercially available steroidal precursors.	cyclopamine	89-100	sonic hedgehog signaling molecule	Homo sapiens	122-125
19552464-2	2009	Biological evaluation of this cyclopamine analogue in two different systems establishes the high potency of 5 as a SHH signaling inhibitor.	cyclopamine	30-41	sonic hedgehog signaling molecule	Homo sapiens	115-118
19742123-6	2009	Cyclopamine treatment induced cytochrome c release from mitochondria and cleavage of caspase 9.	cyclopamine	0-11	caspase 9	Homo sapiens	85-94
19235835-4	2009	We then compare these effects to the phenotypes produced by exposure to two drugs that also inhibit Shh-s: cyclopamine and forskolin.	cyclopamine	107-118	sonic hedgehog signaling molecule a	Danio rerio	100-103
19361493-11	2009	In ovo, cyclopamine treatment before the secondary heart field adds to the outflow tract reduced proliferation only in the caudal secondary heart field, which coincided with the region of high Ptc2 expression.	cyclopamine	8-19	patched 2	Mus musculus	193-197
19235835-8	2009	Despite the differences between cyclopamine and forskolin, we found that shh mRNA injection rescued the short body length, the alteration in somite shape, and the cyclopia produced by ethanol exposure.	cyclopamine	32-43	sonic hedgehog signaling molecule a	Danio rerio	73-76
19384336-11	2009	BMSCs promoted N20.1 cell proliferation and Gli1 mRNA expression, and these effects were abolished by the Shh pathway inhibitor cyclopamine.	cyclopamine	128-139	GLI family zinc finger 1	Rattus norvegicus	44-48
18563554-3	2009	Indeed, two recent studies demonstrated that anchorage-dependent growth of some human breast cancer cell lines is impaired by cyclopamine, a potent hedgehog signaling antagonist targeting the Smoothened (SMO) protein.	cyclopamine	126-137	smoothened, frizzled class receptor	Homo sapiens	192-202
18563554-3	2009	Indeed, two recent studies demonstrated that anchorage-dependent growth of some human breast cancer cell lines is impaired by cyclopamine, a potent hedgehog signaling antagonist targeting the Smoothened (SMO) protein.	cyclopamine	126-137	smoothened, frizzled class receptor	Homo sapiens	204-207
18563554-5	2009	In this paper we demonstrate that hedgehog signaling antagonists, including cyclopamine, and a second compound, CUR0199691, can inhibit growth of estrogen receptor (ER)-positive and ER-negative tumorigenic breast cancer cells at elevated doses.	cyclopamine	76-87	estrogen receptor 1	Homo sapiens	146-163
18563554-5	2009	In this paper we demonstrate that hedgehog signaling antagonists, including cyclopamine, and a second compound, CUR0199691, can inhibit growth of estrogen receptor (ER)-positive and ER-negative tumorigenic breast cancer cells at elevated doses.	cyclopamine	76-87	estrogen receptor 1	Homo sapiens	165-167
18563554-5	2009	In this paper we demonstrate that hedgehog signaling antagonists, including cyclopamine, and a second compound, CUR0199691, can inhibit growth of estrogen receptor (ER)-positive and ER-negative tumorigenic breast cancer cells at elevated doses.	cyclopamine	76-87	estrogen receptor 1	Homo sapiens	182-184
19384336-11	2009	BMSCs promoted N20.1 cell proliferation and Gli1 mRNA expression, and these effects were abolished by the Shh pathway inhibitor cyclopamine.	cyclopamine	128-139	sonic hedgehog signaling molecule	Rattus norvegicus	106-109
19254376-5	2009	In this non-conventional mixed culture system, LNShh cells upregulated the expression of Shh target genes Gli1 and Patched 1 (Ptc1) in MC3T3 cells and this was inhibited by cyclopamine, a specific chemical inhibitor of hedgehog signalling.	cyclopamine	173-184	sonic hedgehog	Mus musculus	49-52
19213939-6	2009	Inhibition of BMP signaling using Noggin or BMP4, specifically, using neutralizing antibodies suppressed endothelial cell formation; whereas, addition of rhBMP4 to cells treated with the hedgehog inhibitor cyclopamine rescued endothelial cell development.	cyclopamine	206-217	bone morphogenetic protein 1	Homo sapiens	14-17
19168578-8	2009	Interestingly, the effects induced by MPs(Shh+) on the formation of capillary-like structures, expression of adhesion molecules and proangiogenic factors were reversed after silencing of the Shh receptor, using small interfering RNA or when Sonic Hedgehog (Shh) signaling was pharmacologically inhibited with cyclopamine.	cyclopamine	309-320	sonic hedgehog signaling molecule	Homo sapiens	42-45
19168578-8	2009	Interestingly, the effects induced by MPs(Shh+) on the formation of capillary-like structures, expression of adhesion molecules and proangiogenic factors were reversed after silencing of the Shh receptor, using small interfering RNA or when Sonic Hedgehog (Shh) signaling was pharmacologically inhibited with cyclopamine.	cyclopamine	309-320	sonic hedgehog signaling molecule	Homo sapiens	191-194
19168578-8	2009	Interestingly, the effects induced by MPs(Shh+) on the formation of capillary-like structures, expression of adhesion molecules and proangiogenic factors were reversed after silencing of the Shh receptor, using small interfering RNA or when Sonic Hedgehog (Shh) signaling was pharmacologically inhibited with cyclopamine.	cyclopamine	309-320	sonic hedgehog signaling molecule	Homo sapiens	241-255
19168578-8	2009	Interestingly, the effects induced by MPs(Shh+) on the formation of capillary-like structures, expression of adhesion molecules and proangiogenic factors were reversed after silencing of the Shh receptor, using small interfering RNA or when Sonic Hedgehog (Shh) signaling was pharmacologically inhibited with cyclopamine.	cyclopamine	309-320	sonic hedgehog signaling molecule	Homo sapiens	191-194
19244133-4	2009	We also show that inhibition of SHH/GLI1 signaling with cyclopamine-KAAD, as well as silencing GLI1 gene expression by small interfering (si)RNA, decreased cell viability and clonogenicity of ALK+ ALCL cells.	cyclopamine	56-67	sonic hedgehog signaling molecule	Homo sapiens	32-35
19244133-4	2009	We also show that inhibition of SHH/GLI1 signaling with cyclopamine-KAAD, as well as silencing GLI1 gene expression by small interfering (si)RNA, decreased cell viability and clonogenicity of ALK+ ALCL cells.	cyclopamine	56-67	GLI family zinc finger 1	Homo sapiens	36-40
19245435-9	2009	Furthermore, combination with 10 microM cyclopamine significantly reduced drug resistance of CD34+ cell lines and primary CD34+ leukemic cells to Ara-C.	cyclopamine	40-51	CD34 molecule	Homo sapiens	93-97
19245435-9	2009	Furthermore, combination with 10 microM cyclopamine significantly reduced drug resistance of CD34+ cell lines and primary CD34+ leukemic cells to Ara-C.	cyclopamine	40-51	CD34 molecule	Homo sapiens	122-126
18814269-5	2009	In vitro generation of RG-derived O4(+) OL progenitors was enhanced by addition of sonic hedgehog (SHH) and reduced by the SHH inhibitor, cyclopamine, suggesting the role of SHH signaling in this process.	cyclopamine	138-149	sonic hedgehog signaling molecule	Homo sapiens	123-126
18814269-5	2009	In vitro generation of RG-derived O4(+) OL progenitors was enhanced by addition of sonic hedgehog (SHH) and reduced by the SHH inhibitor, cyclopamine, suggesting the role of SHH signaling in this process.	cyclopamine	138-149	sonic hedgehog signaling molecule	Homo sapiens	123-126
19254376-5	2009	In this non-conventional mixed culture system, LNShh cells upregulated the expression of Shh target genes Gli1 and Patched 1 (Ptc1) in MC3T3 cells and this was inhibited by cyclopamine, a specific chemical inhibitor of hedgehog signalling.	cyclopamine	173-184	patched 1	Mus musculus	115-124
19254376-5	2009	In this non-conventional mixed culture system, LNShh cells upregulated the expression of Shh target genes Gli1 and Patched 1 (Ptc1) in MC3T3 cells and this was inhibited by cyclopamine, a specific chemical inhibitor of hedgehog signalling.	cyclopamine	173-184	patched 1	Mus musculus	126-130
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	GLI-Kruppel family member GLI1	Mus musculus	57-61
19183261-3	2009	Both agonists produced increases in mRNA expression of Shh-regulated gene targets, Gli-1 and Patched in a cyclopamine- and forskolin-sensitive manner.	cyclopamine	106-117	sonic hedgehog signaling molecule	Homo sapiens	55-58
19183261-3	2009	Both agonists produced increases in mRNA expression of Shh-regulated gene targets, Gli-1 and Patched in a cyclopamine- and forskolin-sensitive manner.	cyclopamine	106-117	GLI family zinc finger 1	Homo sapiens	83-88
19196978-7	2009	Using this system, we demonstrate that cyclopamine, a widely used Hh antagonist, induces a cilial translocation of Smo similar to that reported for Shh ligand and several Hh agonists.	cyclopamine	39-50	smoothened, frizzled class receptor	Homo sapiens	115-118
19196978-7	2009	Using this system, we demonstrate that cyclopamine, a widely used Hh antagonist, induces a cilial translocation of Smo similar to that reported for Shh ligand and several Hh agonists.	cyclopamine	39-50	sonic hedgehog signaling molecule	Homo sapiens	148-151
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	insulin-like growth factor binding protein 6	Mus musculus	63-69
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	cyclin D2	Mus musculus	71-76
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	cyclin D2	Mus musculus	78-87
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	cyclin B1	Mus musculus	90-95
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	cyclin B1	Mus musculus	97-106
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	secreted phosphoprotein 1	Mus musculus	109-113
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	115-118
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	anti-Mullerian hormone	Mus musculus	124-127
19177589-8	2009	In cyclopamine-exposed HB cells, caspase 3 and poly(adenosine diphosphate-ribose) polymerase proteins were specifically activated by their proteolytic cleavage.	cyclopamine	3-14	caspase 3	Homo sapiens	33-42
19736394-7	2009	The transcription factor Gli1 bound to promoter regions of Bcl-2 and IGFBP6 genes and the levels of IGFBP6, proliferating cell nuclear antigen (PCNA) and Bcl-2 messenger RNA (mRNA) were decreased as well as Gli1 mRNA significantly by cyclopamine or RNAi in cultured pancreatic cancer cells (p < 0.01).	cyclopamine	234-245	GLI family zinc finger 1	Homo sapiens	25-29
19224160-3	2009	After identification with FGFR-3 and Col II, the cells were incubated with different concentrations of cyclopamine (cyclo), the specific inhibitor of Ihh signaling pathway.	cyclopamine	103-114	Indian hedgehog signaling molecule	Rattus norvegicus	150-153
19004543-2	2009	Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1).	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	59-62
19004543-2	2009	Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1).	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	107-111
19004543-2	2009	Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1).	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	138-141
19004543-4	2009	Cyclopamine reduced CATB protein and mRNA levels.	cyclopamine	0-11	cathepsin B	Homo sapiens	20-24
19158486-6	2009	Moreover, this activity was accompanied by increased expression of Gli target genes, Patched 1 and Gli2, in LNCaP that could be suppressed by cyclopamine, indicating that chronic androgen-deprivation also re-awakens the autocrine responsiveness of the cancer cells to hedgehog.	cyclopamine	142-153	GLI family zinc finger 1	Homo sapiens	67-70
19158486-6	2009	Moreover, this activity was accompanied by increased expression of Gli target genes, Patched 1 and Gli2, in LNCaP that could be suppressed by cyclopamine, indicating that chronic androgen-deprivation also re-awakens the autocrine responsiveness of the cancer cells to hedgehog.	cyclopamine	142-153	patched 1	Homo sapiens	85-94
19158486-6	2009	Moreover, this activity was accompanied by increased expression of Gli target genes, Patched 1 and Gli2, in LNCaP that could be suppressed by cyclopamine, indicating that chronic androgen-deprivation also re-awakens the autocrine responsiveness of the cancer cells to hedgehog.	cyclopamine	142-153	GLI family zinc finger 2	Homo sapiens	99-103
19738389-7	2009	Treatment with cyclopamine inhibited the proliferation and colony formation of ONB cells, induced ONB cell cycle arrest and apoptosis, and down-regulated the expression of Pacthed1, Gli1 and cyclin D1, but up-regulated p21 expression in vitro.	cyclopamine	15-26	H3 histone pseudogene 16	Homo sapiens	219-222
19738389-4	2009	The impact of the treatment with cyclopamine (a selective inhibitor of the Shh pathway) and/or exogenous Shh on ONB cell proliferation, cycle and apoptosis was examined by MTT, soft agar colony formation and flow cytometry assays, respectively.	cyclopamine	33-44	sonic hedgehog signaling molecule	Homo sapiens	75-78
19738389-8	2009	These regulatory effects of cyclopamine were partially or completely erased by exogenous Shh.	cyclopamine	28-39	sonic hedgehog signaling molecule	Homo sapiens	89-92
19738389-7	2009	Treatment with cyclopamine inhibited the proliferation and colony formation of ONB cells, induced ONB cell cycle arrest and apoptosis, and down-regulated the expression of Pacthed1, Gli1 and cyclin D1, but up-regulated p21 expression in vitro.	cyclopamine	15-26	GLI family zinc finger 1	Homo sapiens	182-186
19365551-3	2009	Here, we demonstrate that cyclopamine and jervine, two structurally related inhibitors of Smo, force ciliary translocation of Smo.	cyclopamine	26-37	smoothened, frizzled class receptor	Homo sapiens	90-93
19365551-3	2009	Here, we demonstrate that cyclopamine and jervine, two structurally related inhibitors of Smo, force ciliary translocation of Smo.	cyclopamine	26-37	smoothened, frizzled class receptor	Homo sapiens	126-129
19120265-3	2008	Here we report that in these precursor cells a hedgehog signaling pathway is activated, as shown by Gli1 expression, and that a dose-dependent inhibition of such a pathway by cyclopamine results in a significant reduction of cell proliferation.	cyclopamine	175-186	GLI family zinc finger 1	Homo sapiens	100-104
19567223-6	2009	This effect was reversed by the simultaneous addition of cyclopamine (1-2 microm), an Shh inhibitor.	cyclopamine	57-68	sonic hedgehog signaling molecule	Homo sapiens	86-89
19738389-7	2009	Treatment with cyclopamine inhibited the proliferation and colony formation of ONB cells, induced ONB cell cycle arrest and apoptosis, and down-regulated the expression of Pacthed1, Gli1 and cyclin D1, but up-regulated p21 expression in vitro.	cyclopamine	15-26	cyclin D1	Homo sapiens	191-200
19203449-7	2009	Cyclopamine treatment resulted in apoptosis as indicated by DNA fragmentation and PI-Annexin V staining.	cyclopamine	0-11	annexin A5	Rattus norvegicus	85-94
19203449-8	2009	The mRNA levels of Gli-1, TGF beta 1, PDGF and Bcl-2 in cyclopamine treated cells were significantly lower than that in control cells (P less than 0.01).	cyclopamine	56-67	GLI family zinc finger 1	Rattus norvegicus	19-24
19203449-8	2009	The mRNA levels of Gli-1, TGF beta 1, PDGF and Bcl-2 in cyclopamine treated cells were significantly lower than that in control cells (P less than 0.01).	cyclopamine	56-67	transforming growth factor, beta 1	Rattus norvegicus	26-36
19203449-8	2009	The mRNA levels of Gli-1, TGF beta 1, PDGF and Bcl-2 in cyclopamine treated cells were significantly lower than that in control cells (P less than 0.01).	cyclopamine	56-67	BCL2, apoptosis regulator	Rattus norvegicus	47-52
19047091-8	2008	Expression of BMI-1, a polycomb gene, is down-regulated in ovarian cancer cells following cyclopamine treatment.	cyclopamine	90-101	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	14-19
19047091-9	2008	Overexpression of PTCH1 phenocopied the effects of cyclopamine; it down-regulated BMI-1 and reduced clonal growth in ovarian cancer cell lines.	cyclopamine	51-62	patched 1	Homo sapiens	18-23
18786173-6	2008	The continuous administration of cyclopamine, a hedgehog signal inhibitor, to the injured site suppressed the increase of BDNF expression and deteriorated the survival of motor neurons in lumbar spinal cord.	cyclopamine	33-44	brain-derived neurotrophic factor	Rattus norvegicus	122-126
19128247-3	2008	Here, we demonstrated the importance of Shh in wound repair, by examining the effects of cyclopamine, a specific inhibitor of the Shh signaling cascade, on tissue repair.	cyclopamine	89-100	sonic hedgehog	Mus musculus	130-133
18682398-13	2008	Importantly, treatment with cyclopamine, a specific inhibitor for hedgehogs, blocked Msx2-induced chondrogenesis.	cyclopamine	28-39	msh homeobox 2	Mus musculus	85-89
18480422-3	2008	To prove or refute this hypothesis, we treated mice with the smoothened (Smo) inhibitor cyclopamine to block the Hh pathway during myocardial ischemia and reperfusion.	cyclopamine	88-99	smoothened, frizzled class receptor	Mus musculus	61-71
18790753-5	2008	In vitro treatment of pancreatic cancer cell lines with IPI-269609 resembled effects observed using cyclopamine (i.e., Gli-responsive reporter knockdown, down-regulation of the Hedgehog target genes Gli1 and Ptch, as well as abrogation of cell migration and colony formation in soft agar).	cyclopamine	100-111	GLI family zinc finger 1	Homo sapiens	119-122
18480422-3	2008	To prove or refute this hypothesis, we treated mice with the smoothened (Smo) inhibitor cyclopamine to block the Hh pathway during myocardial ischemia and reperfusion.	cyclopamine	88-99	smoothened, frizzled class receptor	Mus musculus	73-76
18410405-3	2008	Blockade of the Hh pathway by cyclopamine inhibited pancreatic cancer cell invasion in association with a decreased expression of matrix metalloproteinase (MMP)-9.	cyclopamine	30-41	matrix metallopeptidase 9	Homo sapiens	130-162
18334540-8	2008	In addition, the blockade of the Hh signaling pathway by cyclopamine treatment abrogates the up-regulation of HLA-DR, CD86, CD80, and CD83 expression induced by CD40L on thymic DCs.	cyclopamine	57-68	CD86 molecule	Homo sapiens	118-122
18422746-7	2008	The effect was partially attenuated by specific inhibition of SHH with cyclopamine or a neutralizing antibody.	cyclopamine	71-82	sonic hedgehog signaling molecule	Homo sapiens	62-65
18334540-8	2008	In addition, the blockade of the Hh signaling pathway by cyclopamine treatment abrogates the up-regulation of HLA-DR, CD86, CD80, and CD83 expression induced by CD40L on thymic DCs.	cyclopamine	57-68	CD80 molecule	Homo sapiens	124-128
18334540-8	2008	In addition, the blockade of the Hh signaling pathway by cyclopamine treatment abrogates the up-regulation of HLA-DR, CD86, CD80, and CD83 expression induced by CD40L on thymic DCs.	cyclopamine	57-68	CD83 molecule	Homo sapiens	134-138
18334540-8	2008	In addition, the blockade of the Hh signaling pathway by cyclopamine treatment abrogates the up-regulation of HLA-DR, CD86, CD80, and CD83 expression induced by CD40L on thymic DCs.	cyclopamine	57-68	CD40 ligand	Homo sapiens	161-166
18524848-5	2008	Perturbation of this signaling in the presence of exogenous Shh/cyclopamine significantly (P < 0.001) influenced the proliferation of JVM2 MCL cells.	cyclopamine	64-75	sonic hedgehog signaling molecule	Homo sapiens	60-63
18228117-6	2008	The relationship between HIF-1alpha and Shh was further studied by using cyclopamine and 2-ME2, inhibitor of Shh and HIF-1alpha signaling, respectively, in the cardiomyoblast cell culture under hypoxia.	cyclopamine	73-84	sonic hedgehog signaling molecule	Rattus norvegicus	40-43
17963245-0	2008	Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth.	cyclopamine	0-11	patched 1	Homo sapiens	39-43
17963245-0	2008	Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth.	cyclopamine	0-11	patched 1	Homo sapiens	81-85
17963245-2	2008	Cyclopamine is an alkaloid of the corn lily Veratrum californicum, which blocks activity of the pathway by inhibition of Smoothened (Smo), the signal transduction partner of Ptch.	cyclopamine	0-11	patched 1	Homo sapiens	174-178
18249125-3	2008	To minimize these bystander toxicities, we have designed and synthesized two novel peptide-cyclopamine conjugates as prostate-specific antigen (PSA)-activated prodrugs for use against prostate cancer.	cyclopamine	91-102	kallikrein related peptidase 3	Homo sapiens	117-149
18230052-3	2008	This review explores the relationship between cholesterol and cancer in light of a recent study that demonstrated that the hedgehog (Hh) antagonist cyclopamine blocked expression of the Hh pathway targets PTCH1 and GLI1, lowered Bcl2 levels and increased apoptosis in medulloblastoma cells.	cyclopamine	148-159	patched 1	Homo sapiens	205-210
17996964-3	2008	We investigated the in vivo efficacy of a Shh antagonist, cyclopamine, in correlation to the secondary effects induced by this treatment on gastrin levels and acid secretion.	cyclopamine	58-69	sonic hedgehog	Mus musculus	42-45
17996964-6	2008	We showed that cyclopamine treatment induces both hypergastrinaemia and Shh, and does not inhibit Gli-1.	cyclopamine	15-26	sonic hedgehog	Mus musculus	72-75
17996964-7	2008	Inhibition of the effect of hypergastrinaemia on the Shh pathway, in cyclopamine-treated mice, was demonstrated by use of lansoprazole which concomitantly inhibited Gli-1, and did not increase Shh production.	cyclopamine	69-80	sonic hedgehog	Mus musculus	53-56
18230052-3	2008	This review explores the relationship between cholesterol and cancer in light of a recent study that demonstrated that the hedgehog (Hh) antagonist cyclopamine blocked expression of the Hh pathway targets PTCH1 and GLI1, lowered Bcl2 levels and increased apoptosis in medulloblastoma cells.	cyclopamine	148-159	GLI family zinc finger 1	Homo sapiens	215-219
18230052-3	2008	This review explores the relationship between cholesterol and cancer in light of a recent study that demonstrated that the hedgehog (Hh) antagonist cyclopamine blocked expression of the Hh pathway targets PTCH1 and GLI1, lowered Bcl2 levels and increased apoptosis in medulloblastoma cells.	cyclopamine	148-159	BCL2 apoptosis regulator	Homo sapiens	229-233
17602833-0	2007	The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells.	cyclopamine	31-42	interferon alpha inducible protein 27	Homo sapiens	63-66
18365871-3	2007	Importantly, the combination of mitoxantrone plus gefitinib and/or cyclopamine also caused a higher rate of apoptotic death of PC cells including enriched fraction of CD44(high) PC3 cell subpopulation as compared to the individual agents or bi-combination of drugs.	cyclopamine	67-78	CD44 molecule (Indian blood group)	Homo sapiens	167-171
18365871-4	2007	The cytotoxic effects induced by mitoxantrone, gefitinib and cyclopamine on PC3 cells appear to be at least partly mediated through the depolarization of the mitochondrial membrane, release of cytochrome c into the cytosol, hydrogen peroxide production and activation of caspase cascades.	cyclopamine	61-72	cytochrome c, somatic	Homo sapiens	193-205
17804404-4	2007	Blockage of the Shh signaling pathway with a pharmacological inhibitor, cyclopamine, abolished the CEPO-induced neurogenesis.	cyclopamine	72-83	sonic hedgehog	Mus musculus	16-19
17638575-13	2007	The hedgehog signaling inhibitor, cyclopamine, reversed the inhibitory effects of 20S and Shh on troglitazone-induced adipocyte formation in 10-day cultures of M2 cells by 70% and 100%, respectively, and the inhibitory effect of 20S and Shh on troglitazone-induced PPARgamma expression was fully reversed at 48 h by cyclopamine.	cyclopamine	34-45	DNA segment, 20S	Mus musculus	82-85
17638575-13	2007	The hedgehog signaling inhibitor, cyclopamine, reversed the inhibitory effects of 20S and Shh on troglitazone-induced adipocyte formation in 10-day cultures of M2 cells by 70% and 100%, respectively, and the inhibitory effect of 20S and Shh on troglitazone-induced PPARgamma expression was fully reversed at 48 h by cyclopamine.	cyclopamine	34-45	sonic hedgehog	Mus musculus	90-93
17638575-13	2007	The hedgehog signaling inhibitor, cyclopamine, reversed the inhibitory effects of 20S and Shh on troglitazone-induced adipocyte formation in 10-day cultures of M2 cells by 70% and 100%, respectively, and the inhibitory effect of 20S and Shh on troglitazone-induced PPARgamma expression was fully reversed at 48 h by cyclopamine.	cyclopamine	34-45	DNA segment, 20S	Mus musculus	229-232
17638575-13	2007	The hedgehog signaling inhibitor, cyclopamine, reversed the inhibitory effects of 20S and Shh on troglitazone-induced adipocyte formation in 10-day cultures of M2 cells by 70% and 100%, respectively, and the inhibitory effect of 20S and Shh on troglitazone-induced PPARgamma expression was fully reversed at 48 h by cyclopamine.	cyclopamine	34-45	sonic hedgehog	Mus musculus	237-240
17638575-13	2007	The hedgehog signaling inhibitor, cyclopamine, reversed the inhibitory effects of 20S and Shh on troglitazone-induced adipocyte formation in 10-day cultures of M2 cells by 70% and 100%, respectively, and the inhibitory effect of 20S and Shh on troglitazone-induced PPARgamma expression was fully reversed at 48 h by cyclopamine.	cyclopamine	34-45	peroxisome proliferator activated receptor gamma	Mus musculus	265-274
17638575-13	2007	The hedgehog signaling inhibitor, cyclopamine, reversed the inhibitory effects of 20S and Shh on troglitazone-induced adipocyte formation in 10-day cultures of M2 cells by 70% and 100%, respectively, and the inhibitory effect of 20S and Shh on troglitazone-induced PPARgamma expression was fully reversed at 48 h by cyclopamine.	cyclopamine	316-327	DNA segment, 20S	Mus musculus	82-85
17490411-12	2007	In cyclopamine-exposed cultures of E12.5 tissue, SMAA, SMGA, GLI1, and BMP4 gene expression was significantly decreased compared with controls, but PCNA gene expression did not change.	cyclopamine	3-14	actin, gamma 2, smooth muscle, enteric	Mus musculus	55-59
17490411-12	2007	In cyclopamine-exposed cultures of E12.5 tissue, SMAA, SMGA, GLI1, and BMP4 gene expression was significantly decreased compared with controls, but PCNA gene expression did not change.	cyclopamine	3-14	GLI-Kruppel family member GLI1	Mus musculus	61-65
17490411-12	2007	In cyclopamine-exposed cultures of E12.5 tissue, SMAA, SMGA, GLI1, and BMP4 gene expression was significantly decreased compared with controls, but PCNA gene expression did not change.	cyclopamine	3-14	bone morphogenetic protein 4	Mus musculus	71-75
17490411-12	2007	In cyclopamine-exposed cultures of E12.5 tissue, SMAA, SMGA, GLI1, and BMP4 gene expression was significantly decreased compared with controls, but PCNA gene expression did not change.	cyclopamine	3-14	proliferating cell nuclear antigen	Mus musculus	148-152
17490411-13	2007	In cyclopamine-exposed E14.5 cultures, SMGA and SM-MHC gene expression did not change compared with controls.	cyclopamine	3-14	actin, gamma 2, smooth muscle, enteric	Mus musculus	39-43
17490411-13	2007	In cyclopamine-exposed E14.5 cultures, SMGA and SM-MHC gene expression did not change compared with controls.	cyclopamine	3-14	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	48-54
17893326-4	2007	Cultured GNPs express Mad3 in response to Shh stimulation in a cyclopamine-dependent manner.	cyclopamine	63-74	Max dimerization protein 3	Mus musculus	22-26
17893326-4	2007	Cultured GNPs express Mad3 in response to Shh stimulation in a cyclopamine-dependent manner.	cyclopamine	63-74	sonic hedgehog	Mus musculus	42-45
17602833-0	2007	The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells.	cyclopamine	31-42	insulin like growth factor 2	Homo sapiens	101-107
17602833-0	2007	The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells.	cyclopamine	31-42	AKT serine/threonine kinase 1	Homo sapiens	126-129
17602833-5	2007	A phospho-site protein kinase screen showed that cyclopamine decreased levels of phospho-Thr(187)-p27 by 71%.	cyclopamine	49-60	interferon alpha inducible protein 27	Homo sapiens	98-101
17602833-7	2007	Consistent with this hypothesis, treatment of PC-3 cells with cyclopamine resulted in a approximately 3-fold increase in p27 protein levels.	cyclopamine	62-73	interferon alpha inducible protein 27	Homo sapiens	121-124
17602833-8	2007	Cdk-2 phosphorylates Thr(187)-p27, and immunoblotting demonstrated that cyclopamine treatment of PC-3 cells reduces the expression of cdk-2.	cyclopamine	72-83	cyclin dependent kinase 2	Homo sapiens	0-5
17602833-8	2007	Cdk-2 phosphorylates Thr(187)-p27, and immunoblotting demonstrated that cyclopamine treatment of PC-3 cells reduces the expression of cdk-2.	cyclopamine	72-83	interferon alpha inducible protein 27	Homo sapiens	30-33
17602833-8	2007	Cdk-2 phosphorylates Thr(187)-p27, and immunoblotting demonstrated that cyclopamine treatment of PC-3 cells reduces the expression of cdk-2.	cyclopamine	72-83	cyclin dependent kinase 2	Homo sapiens	134-139
17602833-9	2007	Furthermore, cyclopamine decreased the levels of phosphorylated (activated) Akt, which is known to increase p27 degradation via Skp-2-induced ubiquitination.	cyclopamine	13-24	AKT serine/threonine kinase 1	Homo sapiens	76-79
17602833-9	2007	Furthermore, cyclopamine decreased the levels of phosphorylated (activated) Akt, which is known to increase p27 degradation via Skp-2-induced ubiquitination.	cyclopamine	13-24	interferon alpha inducible protein 27	Homo sapiens	108-111
17602833-9	2007	Furthermore, cyclopamine decreased the levels of phosphorylated (activated) Akt, which is known to increase p27 degradation via Skp-2-induced ubiquitination.	cyclopamine	13-24	S-phase kinase associated protein 2	Homo sapiens	128-133
17602833-10	2007	The mechanism by which cyclopamine decreases phosphorylated Akt is currently under investigation, but it may involve our observed cyclopamine-induced reduction in IRS-1 and IGF-II expression.	cyclopamine	23-34	AKT serine/threonine kinase 1	Homo sapiens	60-63
17602833-10	2007	The mechanism by which cyclopamine decreases phosphorylated Akt is currently under investigation, but it may involve our observed cyclopamine-induced reduction in IRS-1 and IGF-II expression.	cyclopamine	23-34	insulin like growth factor 2	Homo sapiens	173-179
17602833-10	2007	The mechanism by which cyclopamine decreases phosphorylated Akt is currently under investigation, but it may involve our observed cyclopamine-induced reduction in IRS-1 and IGF-II expression.	cyclopamine	130-141	insulin receptor substrate 1	Homo sapiens	163-168
17602833-10	2007	The mechanism by which cyclopamine decreases phosphorylated Akt is currently under investigation, but it may involve our observed cyclopamine-induced reduction in IRS-1 and IGF-II expression.	cyclopamine	130-141	insulin like growth factor 2	Homo sapiens	173-179
17914115-11	2007	Real-time RT-PCR revealed conservation of the Hh target genes Gli1, Gli2, and Ptch in the pancreatic carcinoid cell line BON-1, which were downregulated upon Hh inhibition with cyclopamine.	cyclopamine	177-188	GLI family zinc finger 1	Homo sapiens	62-66
17628016-5	2007	Hedgehog pathway blockade by cyclopamine caused a 40%-60% reduction in growth of adherent glioma lines highly expressing Gli1 but not in those lacking evidence of pathway activity.	cyclopamine	29-40	GLI-Kruppel family member GLI1	Mus musculus	121-125
17688959-4	2007	These effects are reversed by cyclopamine, a specific chemical inhibitor of the Shh pathway.	cyclopamine	30-41	sonic hedgehog	Mus musculus	80-83
17914115-11	2007	Real-time RT-PCR revealed conservation of the Hh target genes Gli1, Gli2, and Ptch in the pancreatic carcinoid cell line BON-1, which were downregulated upon Hh inhibition with cyclopamine.	cyclopamine	177-188	GLI family zinc finger 2	Homo sapiens	68-72
17914115-11	2007	Real-time RT-PCR revealed conservation of the Hh target genes Gli1, Gli2, and Ptch in the pancreatic carcinoid cell line BON-1, which were downregulated upon Hh inhibition with cyclopamine.	cyclopamine	177-188	patched 1	Homo sapiens	78-82
17610861-4	2007	We find that cyclopamine, a potent antagonist of Shh signaling, can down-regulate hedgehog target genes in the posterior limb throughout the time Shh is expressed, indicating that continued active Shh signaling indeed takes place.	cyclopamine	13-24	sonic hedgehog	Mus musculus	49-52
17428963-7	2007	Silencing the effects of Shh with cyclopamine, a specific inhibitor of Shh, or siRNA, an inhibitor of the Shh receptor Patched, strongly reduced production of NO elicited by MPs.	cyclopamine	34-45	sonic hedgehog signaling molecule	Homo sapiens	25-28
17610861-4	2007	We find that cyclopamine, a potent antagonist of Shh signaling, can down-regulate hedgehog target genes in the posterior limb throughout the time Shh is expressed, indicating that continued active Shh signaling indeed takes place.	cyclopamine	13-24	sonic hedgehog	Mus musculus	146-149
17610861-4	2007	We find that cyclopamine, a potent antagonist of Shh signaling, can down-regulate hedgehog target genes in the posterior limb throughout the time Shh is expressed, indicating that continued active Shh signaling indeed takes place.	cyclopamine	13-24	sonic hedgehog	Mus musculus	146-149
17640486-1	2007	AIM: To investigate the expression of sonic hedgehog (SHH) and epidermal growth factor receptor (EGFR) signal molecules in pancreatic cancer cells, and to assess the inhibitory effects through the blockade of the SHH and EGFR signaling pathways by cyclopamine and Iressa, respectively.	cyclopamine	248-259	sonic hedgehog signaling molecule	Homo sapiens	38-52
17640486-6	2007	Cyclopamine could downregulate the expression of EGFR in all cell lines.	cyclopamine	0-11	epidermal growth factor receptor	Homo sapiens	49-53
17320852-10	2007	Cyclopamine treatment before stage 20 can rescue the effects of shh overexpression, indicating that early Hh signaling plays an essential role in maintaining the balance between epaxial and hypaxial muscle mass.	cyclopamine	0-11	sonic hedgehog L homeolog	Xenopus laevis	64-67
17300775-7	2007	We find, however, that Tbx2 expression is neither affected by blocking Shh signaling with cyclopamine nor by genetic removal of several BMP activities in the limb bud.	cyclopamine	90-101	T-box transcription factor 2	Gallus gallus	23-27
17504919-9	2007	Real-time analysis of adult mouse testis tubules cultured in the presence of the Hedgehog signalling inhibitor, cyclopamine, showed a downregulation of Wsb2 mRNA after treatment which suggests that Wsb2 may be a target of Hedgehog signalling.	cyclopamine	112-123	WD repeat and SOCS box-containing 2	Mus musculus	152-156
17504919-9	2007	Real-time analysis of adult mouse testis tubules cultured in the presence of the Hedgehog signalling inhibitor, cyclopamine, showed a downregulation of Wsb2 mRNA after treatment which suggests that Wsb2 may be a target of Hedgehog signalling.	cyclopamine	112-123	WD repeat and SOCS box-containing 2	Mus musculus	198-202
17363490-0	2007	Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells.	cyclopamine	95-106	epidermal growth factor receptor	Homo sapiens	22-54
17200122-5	2007	This was demonstrated by 1) oxysterol-induced expression of the Hh target genes Gli-1 and Patched, 2) oxysterol-induced activation of a luciferase reporter driven by a multimerized Gli-responsive element, 3) inhibition of oxysterol effects by the hedgehog pathway inhibitor, cyclopamine, and 4) unresponsiveness of Smoothened-/- mouse embryonic fibroblasts to oxysterols.	cyclopamine	275-286	GLI-Kruppel family member GLI1	Mus musculus	80-100
17332280-10	2007	In addition, the cyclopamine/siGli1-induced growth suppression was associated with the down-regulation of cyclins D1 and A and N-myc.	cyclopamine	17-28	cyclin D1	Homo sapiens	106-122
17332280-10	2007	In addition, the cyclopamine/siGli1-induced growth suppression was associated with the down-regulation of cyclins D1 and A and N-myc.	cyclopamine	17-28	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	127-132
17332349-3	2007	In pancreatic cancer cell lines, Hh inhibition with cyclopamine resulted in down-regulation of snail and up-regulation of E-cadherin, consistent with inhibition of epithelial-to-mesenchymal transition, and was mirrored by a striking reduction of in vitro invasive capacity (P < 0.0001).	cyclopamine	52-63	cadherin 1	Homo sapiens	122-132
17196391-9	2007	Finally, interference of HH-GLI signaling with cyclopamine or through lentiviral-mediated silencing demonstrates that the tumorigenicity of human gliomas in mice requires an active pathway.	cyclopamine	47-58	GLI family zinc finger 1	Homo sapiens	28-31
17273793-8	2007	The addition of cyclopamine, an inhibitor of Shh signaling, to NIH3T3 cells, suppressed the regulation of Ang-1 and Ang-2 mRNA levels in the presence of Shh.	cyclopamine	16-27	sonic hedgehog	Mus musculus	45-48
17273793-8	2007	The addition of cyclopamine, an inhibitor of Shh signaling, to NIH3T3 cells, suppressed the regulation of Ang-1 and Ang-2 mRNA levels in the presence of Shh.	cyclopamine	16-27	angiopoietin 1	Mus musculus	106-111
17273793-8	2007	The addition of cyclopamine, an inhibitor of Shh signaling, to NIH3T3 cells, suppressed the regulation of Ang-1 and Ang-2 mRNA levels in the presence of Shh.	cyclopamine	16-27	angiopoietin 2	Mus musculus	116-121
17273793-8	2007	The addition of cyclopamine, an inhibitor of Shh signaling, to NIH3T3 cells, suppressed the regulation of Ang-1 and Ang-2 mRNA levels in the presence of Shh.	cyclopamine	16-27	sonic hedgehog	Mus musculus	153-156
17083567-7	2007	Treatment with cyclopamine induced not only G, arrest but also apoptosis along with the downregulation of cyclin A and cyclin D1, and the upregulation of p21 and p27.	cyclopamine	15-26	cyclin A2	Homo sapiens	106-114
17762973-5	2007	The Hedgehog pathway antagonist cyclopamine effectively reduced Shh-induced proliferation to control levels.	cyclopamine	32-43	sonic hedgehog	Mus musculus	64-67
17200206-5	2007	The Hedgehog antagonist cyclopamine blocked expression of the Hh pathway targets PTCH1 and Gli1, lowered BclII levels, and increased apoptosis in DAOY and UW228 medulloblastoma cells.	cyclopamine	24-35	patched 1	Homo sapiens	81-86
17200206-5	2007	The Hedgehog antagonist cyclopamine blocked expression of the Hh pathway targets PTCH1 and Gli1, lowered BclII levels, and increased apoptosis in DAOY and UW228 medulloblastoma cells.	cyclopamine	24-35	GLI family zinc finger 1	Homo sapiens	91-95
17200206-6	2007	Apoptotic induction caused by cyclopamine could be rescued in part by enforced expression of Gli1 or BclII.	cyclopamine	30-41	GLI family zinc finger 1	Homo sapiens	93-97
17083567-7	2007	Treatment with cyclopamine induced not only G, arrest but also apoptosis along with the downregulation of cyclin A and cyclin D1, and the upregulation of p21 and p27.	cyclopamine	15-26	cyclin D1	Homo sapiens	119-128
17083567-7	2007	Treatment with cyclopamine induced not only G, arrest but also apoptosis along with the downregulation of cyclin A and cyclin D1, and the upregulation of p21 and p27.	cyclopamine	15-26	cyclin dependent kinase inhibitor 1A	Homo sapiens	154-157
17083567-7	2007	Treatment with cyclopamine induced not only G, arrest but also apoptosis along with the downregulation of cyclin A and cyclin D1, and the upregulation of p21 and p27.	cyclopamine	15-26	interferon alpha inducible protein 27	Homo sapiens	162-165
17028036-0	2006	Cyclopamine treatment of human embryonic stem cells followed by culture in human astrocyte medium promotes differentiation into nestin- and GFAP-expressing astrocytic lineage.	cyclopamine	0-11	glial fibrillary acidic protein	Homo sapiens	140-144
17028036-7	2006	These findings indicate that treatment with cyclopamine followed by culturing in HAM leads to the differentiation of hESCs into nestin- and GFAP-expressing astrocytic lineage.	cyclopamine	44-55	glial fibrillary acidic protein	Homo sapiens	140-144
17075873-10	2006	A limb treated with cyclopamine (a shh inhibitor) has a gene expression pattern (hoxd11-negative) similar to that in shh-deficient mice, suggesting that a hindlimb treated with cyclopamine has a digit I character.	cyclopamine	20-31	sonic hedgehog	Mus musculus	35-38
16552573-5	2006	Assays of apoptosis (annexin V) were performed in the presence of cyclopamine, chemotherapeutic agents, and IR.	cyclopamine	66-77	annexin A5	Homo sapiens	21-30
17075873-10	2006	A limb treated with cyclopamine (a shh inhibitor) has a gene expression pattern (hoxd11-negative) similar to that in shh-deficient mice, suggesting that a hindlimb treated with cyclopamine has a digit I character.	cyclopamine	20-31	homeobox D11	Mus musculus	81-87
17075873-10	2006	A limb treated with cyclopamine (a shh inhibitor) has a gene expression pattern (hoxd11-negative) similar to that in shh-deficient mice, suggesting that a hindlimb treated with cyclopamine has a digit I character.	cyclopamine	177-188	sonic hedgehog	Mus musculus	35-38
17075873-10	2006	A limb treated with cyclopamine (a shh inhibitor) has a gene expression pattern (hoxd11-negative) similar to that in shh-deficient mice, suggesting that a hindlimb treated with cyclopamine has a digit I character.	cyclopamine	177-188	homeobox D11	Mus musculus	81-87
16707121-6	2006	Functional redundancy between the three Gli transcription factors appears to mitigate the effect of Gli2 LOF as evidenced by residual Hh pathway activity in the E14 Gli2(-/-) UGS that could be inhibited by cyclopamine treatment.	cyclopamine	206-217	GLI-Kruppel family member GLI2	Mus musculus	100-104
17088430-5	2006	The expression of Tcf-4, a transcription factor known to be required for intestinal epithelial stem cell proliferation, was increased and mislocalized in the intestinal epithelia of the beta1 integrin-deleted mice and in newborn mice treated with the Hedgehog signaling inhibitor cyclopamine.	cyclopamine	280-291	transcription factor 4	Mus musculus	18-23
17102592-12	2006	In cyclopamine-treated NECs, downregulation of Gli1, Ptch1, Snail and hASH1, and upregulation of E-cadherin were demonstrated at mRNA levels.	cyclopamine	3-14	GLI family zinc finger 1	Homo sapiens	47-51
17102592-12	2006	In cyclopamine-treated NECs, downregulation of Gli1, Ptch1, Snail and hASH1, and upregulation of E-cadherin were demonstrated at mRNA levels.	cyclopamine	3-14	patched 1	Homo sapiens	53-58
17102592-12	2006	In cyclopamine-treated NECs, downregulation of Gli1, Ptch1, Snail and hASH1, and upregulation of E-cadherin were demonstrated at mRNA levels.	cyclopamine	3-14	snail family transcriptional repressor 1	Homo sapiens	60-65
17102592-12	2006	In cyclopamine-treated NECs, downregulation of Gli1, Ptch1, Snail and hASH1, and upregulation of E-cadherin were demonstrated at mRNA levels.	cyclopamine	3-14	achaete-scute family bHLH transcription factor 1	Homo sapiens	70-75
17102592-12	2006	In cyclopamine-treated NECs, downregulation of Gli1, Ptch1, Snail and hASH1, and upregulation of E-cadherin were demonstrated at mRNA levels.	cyclopamine	3-14	cadherin 1	Homo sapiens	97-107
16989805-13	2006	Finally, by blocking Shh activity with cyclopamine, we find evidence that continued Shh activity is also required to maintain refractoriness to Gremlin expression in response to Bmp activity.	cyclopamine	39-50	sonic hedgehog signaling molecule	Homo sapiens	21-24
16989805-13	2006	Finally, by blocking Shh activity with cyclopamine, we find evidence that continued Shh activity is also required to maintain refractoriness to Gremlin expression in response to Bmp activity.	cyclopamine	39-50	sonic hedgehog signaling molecule	Homo sapiens	84-87
16989805-13	2006	Finally, by blocking Shh activity with cyclopamine, we find evidence that continued Shh activity is also required to maintain refractoriness to Gremlin expression in response to Bmp activity.	cyclopamine	39-50	gremlin 1, DAN family BMP antagonist	Homo sapiens	144-151
16989805-13	2006	Finally, by blocking Shh activity with cyclopamine, we find evidence that continued Shh activity is also required to maintain refractoriness to Gremlin expression in response to Bmp activity.	cyclopamine	39-50	bone morphogenetic protein 1	Homo sapiens	178-181
16867986-6	2006	We also provide experiments showing that human Smo, when expressed in Schneider cells, is able to bind the alkaloid cyclopamine, suggesting that it is expressed in a native conformational state.	cyclopamine	116-127	smoothened, frizzled class receptor	Homo sapiens	47-50
16890607-8	2006	Importantly, PPARbeta acts on Paneth cell homeostasis by down-regulating the expression of Ihh, an effect that can be mimicked by cyclopamine, a known inhibitor of the hedgehog signaling pathway.	cyclopamine	130-141	peroxisome proliferator activator receptor delta	Mus musculus	13-21
16890607-8	2006	Importantly, PPARbeta acts on Paneth cell homeostasis by down-regulating the expression of Ihh, an effect that can be mimicked by cyclopamine, a known inhibitor of the hedgehog signaling pathway.	cyclopamine	130-141	Indian hedgehog	Mus musculus	91-94
16982050-12	2006	Treatment of zebrafish embryos with cyclopamine, which disrupts hedgehog signaling, abolished cypher expression in 9 somite and 15-somite stage embryos.	cyclopamine	36-47	LIM domain binding 3a	Danio rerio	94-100
16707121-6	2006	Functional redundancy between the three Gli transcription factors appears to mitigate the effect of Gli2 LOF as evidenced by residual Hh pathway activity in the E14 Gli2(-/-) UGS that could be inhibited by cyclopamine treatment.	cyclopamine	206-217	GLI-Kruppel family member GLI2	Mus musculus	165-169
16571640-4	2006	Next, treatment of HPESCs with media conditioned by Shh-N-expressing cells promoted cell proliferation, whereas inhibition of Shh by cyclopamine, a specific inhibitor of Shh signalling, had an opposite effect.	cyclopamine	133-144	sonic hedgehog signaling molecule	Homo sapiens	126-129
16571640-4	2006	Next, treatment of HPESCs with media conditioned by Shh-N-expressing cells promoted cell proliferation, whereas inhibition of Shh by cyclopamine, a specific inhibitor of Shh signalling, had an opposite effect.	cyclopamine	133-144	sonic hedgehog signaling molecule	Homo sapiens	126-129
16571640-5	2006	Interestingly, the mitogenic effect of epidermal growth factor (EGF) on HPESCs was efficiently abolished by cyclopamine.	cyclopamine	108-119	epidermal growth factor	Homo sapiens	39-62
16571640-5	2006	Interestingly, the mitogenic effect of epidermal growth factor (EGF) on HPESCs was efficiently abolished by cyclopamine.	cyclopamine	108-119	epidermal growth factor	Homo sapiens	64-67
16197497-4	2005	Here we demonstrate that the ECS-induced increase in proliferation of adult hippocampal progenitors was completely blocked in animals treated with cyclopamine, a pharmacological inhibitor of Shh signalling.	cyclopamine	147-158	sonic hedgehog signaling molecule	Rattus norvegicus	191-194
16571352-9	2006	Using MEFs expressing only Gli2 or Gli3, we found that both cyclopamine and the PKA activator forskolin inhibited target gene induction mediated by Gli2 and Gli3.	cyclopamine	60-71	GLI-Kruppel family member GLI2	Mus musculus	27-31
16571352-9	2006	Using MEFs expressing only Gli2 or Gli3, we found that both cyclopamine and the PKA activator forskolin inhibited target gene induction mediated by Gli2 and Gli3.	cyclopamine	60-71	GLI-Kruppel family member GLI3	Mus musculus	35-39
16571352-9	2006	Using MEFs expressing only Gli2 or Gli3, we found that both cyclopamine and the PKA activator forskolin inhibited target gene induction mediated by Gli2 and Gli3.	cyclopamine	60-71	GLI-Kruppel family member GLI2	Mus musculus	148-152
16571352-9	2006	Using MEFs expressing only Gli2 or Gli3, we found that both cyclopamine and the PKA activator forskolin inhibited target gene induction mediated by Gli2 and Gli3.	cyclopamine	60-71	GLI-Kruppel family member GLI3	Mus musculus	157-161
16895439-7	2006	Vitamin D3 bound to Smo with high affinity in a cyclopamine-sensitive manner.	cyclopamine	48-59	smoothened, frizzled class receptor	Danio rerio	20-23
16108016-0	2006	Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells.	cyclopamine	46-57	epidermal growth factor receptor	Homo sapiens	100-132
16108016-3	2006	The results revealed that cyclopamine, alone or at a lower concentration in combination with gefitinib, inhibited the growth of sonic hedgehog- (SHH), epidermal growth factor- (EGF) and serum-stimulated androgen-sensitive LNCaP-C33 and LNCaP-LN3 and androgen-independent LNCaP-C81, DU145 and PC3 cells.	cyclopamine	26-37	sonic hedgehog signaling molecule	Homo sapiens	145-148
16396903-4	2006	Shh deficiency or cyclopamine-mediated SMO inhibition disrupted renal organogenesis, decreased expression of GLI1 and GLI2 proteins, but increased expression of GLI3 repressor relative to GLI3 activator.	cyclopamine	18-29	smoothened, frizzled class receptor	Mus musculus	39-42
16396903-4	2006	Shh deficiency or cyclopamine-mediated SMO inhibition disrupted renal organogenesis, decreased expression of GLI1 and GLI2 proteins, but increased expression of GLI3 repressor relative to GLI3 activator.	cyclopamine	18-29	GLI-Kruppel family member GLI1	Mus musculus	109-113
16396903-4	2006	Shh deficiency or cyclopamine-mediated SMO inhibition disrupted renal organogenesis, decreased expression of GLI1 and GLI2 proteins, but increased expression of GLI3 repressor relative to GLI3 activator.	cyclopamine	18-29	GLI-Kruppel family member GLI2	Mus musculus	118-122
16396903-4	2006	Shh deficiency or cyclopamine-mediated SMO inhibition disrupted renal organogenesis, decreased expression of GLI1 and GLI2 proteins, but increased expression of GLI3 repressor relative to GLI3 activator.	cyclopamine	18-29	GLI-Kruppel family member GLI3	Mus musculus	161-165
16396903-4	2006	Shh deficiency or cyclopamine-mediated SMO inhibition disrupted renal organogenesis, decreased expression of GLI1 and GLI2 proteins, but increased expression of GLI3 repressor relative to GLI3 activator.	cyclopamine	18-29	GLI-Kruppel family member GLI3	Mus musculus	188-192
16396903-9	2006	By contrast, treatment of embryonic kidney explants with cyclopamine decreased GLI1 and/or GLI2 binding, and induced binding of GLI3.	cyclopamine	57-68	GLI-Kruppel family member GLI1	Mus musculus	79-83
16396903-9	2006	By contrast, treatment of embryonic kidney explants with cyclopamine decreased GLI1 and/or GLI2 binding, and induced binding of GLI3.	cyclopamine	57-68	GLI-Kruppel family member GLI2	Mus musculus	91-95
16396903-9	2006	By contrast, treatment of embryonic kidney explants with cyclopamine decreased GLI1 and/or GLI2 binding, and induced binding of GLI3.	cyclopamine	57-68	GLI-Kruppel family member GLI3	Mus musculus	128-132
16397407-7	2006	Blocking the hedgehog pathway with cyclopamine inhibited proliferation, induced apoptosis and repressed c-Myc and cyclin D expression in a subset of HCC cell lines.	cyclopamine	35-46	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	104-109
17179732-7	2006	Cyclopamine significantly inhibited cell proliferation and migration in ESCC cells that expressed Gli-1.	cyclopamine	0-11	GLI family zinc finger 1	Homo sapiens	98-103
16159933-9	2005	Shh inhibited cell proliferation in AtT-20 corticotrophinoma cells and the Shh-specific inhibitor cyclopamine increased proliferation in GH3 mammosomatotrophinoma cells.	cyclopamine	98-109	sonic hedgehog	Mus musculus	75-78
15905200-8	2005	Overexpression of Gli1 under the control of the cytomegalovirus (CMV) promoter renders these cells resistant to cyclopamine-induced apoptosis.	cyclopamine	112-123	GLI family zinc finger 1	Homo sapiens	18-22
16897213-1	2006	PURPOSE: To evaluate the effect of cyclopamine, an inhibitor of the Sonic hedgehog (Shh) signal, on the growth of an epithelial neoplasm.	cyclopamine	35-46	sonic hedgehog	Mus musculus	68-82
16897213-1	2006	PURPOSE: To evaluate the effect of cyclopamine, an inhibitor of the Sonic hedgehog (Shh) signal, on the growth of an epithelial neoplasm.	cyclopamine	35-46	sonic hedgehog	Mus musculus	84-87
16897213-7	2006	RESULTS: Histology showed that cyclopamine treatment suppressed BrdU incorporation and induced apoptosis in the majority of cells in tumors chemically induced in the eyelid of the XPC-null mice.	cyclopamine	31-42	xeroderma pigmentosum, complementation group C	Mus musculus	180-183
16897213-10	2006	On the other hand, the SCC cells expressed Shh in vivo in tumors developed in nude mice, but cyclopamine suppressed cell proliferation in the tumors, and the Shh-signaling pathway was inhibited by cyclopamine-induced apoptosis.	cyclopamine	197-208	sonic hedgehog	Mus musculus	43-46
16897213-10	2006	On the other hand, the SCC cells expressed Shh in vivo in tumors developed in nude mice, but cyclopamine suppressed cell proliferation in the tumors, and the Shh-signaling pathway was inhibited by cyclopamine-induced apoptosis.	cyclopamine	197-208	sonic hedgehog	Mus musculus	158-161
16630542-8	2006	Moreover, when cells were pretreated with cyclopamine, Shh could not elevate [Ca2+]i, activate ERK or promote DNA synthesis.	cyclopamine	42-53	sonic hedgehog signaling molecule	Rattus norvegicus	55-58
16855373-0	2006	Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer.	cyclopamine	35-46	sonic hedgehog signaling molecule	Homo sapiens	0-8
16855373-7	2006	Hedgehog-mediated transcription, as indicated by a reporter of GLI-dependent promoter activity and by expression of GLI1 transcripts, was reduced by the hedgehog pathway inhibitor cyclopamine in both MDA-MB-435 cancer epithelial cells and MCF10AT epithelial cells, a cell line derived from benign breast.	cyclopamine	180-191	sonic hedgehog signaling molecule	Homo sapiens	0-8
16855373-7	2006	Hedgehog-mediated transcription, as indicated by a reporter of GLI-dependent promoter activity and by expression of GLI1 transcripts, was reduced by the hedgehog pathway inhibitor cyclopamine in both MDA-MB-435 cancer epithelial cells and MCF10AT epithelial cells, a cell line derived from benign breast.	cyclopamine	180-191	GLI family zinc finger 1	Homo sapiens	63-66
16855373-7	2006	Hedgehog-mediated transcription, as indicated by a reporter of GLI-dependent promoter activity and by expression of GLI1 transcripts, was reduced by the hedgehog pathway inhibitor cyclopamine in both MDA-MB-435 cancer epithelial cells and MCF10AT epithelial cells, a cell line derived from benign breast.	cyclopamine	180-191	GLI family zinc finger 1	Homo sapiens	116-120
16855373-7	2006	Hedgehog-mediated transcription, as indicated by a reporter of GLI-dependent promoter activity and by expression of GLI1 transcripts, was reduced by the hedgehog pathway inhibitor cyclopamine in both MDA-MB-435 cancer epithelial cells and MCF10AT epithelial cells, a cell line derived from benign breast.	cyclopamine	180-191	sonic hedgehog signaling molecule	Homo sapiens	153-161
16855373-9	2006	Treatment with sonic hedgehog ligand diminished the cyclopamine-induced reduction in GLI-dependent promoter activity in MCF10AT and MDA-MB-435 and viability of MDA-MB-435.	cyclopamine	52-63	sonic hedgehog signaling molecule	Homo sapiens	15-29
16855373-9	2006	Treatment with sonic hedgehog ligand diminished the cyclopamine-induced reduction in GLI-dependent promoter activity in MCF10AT and MDA-MB-435 and viability of MDA-MB-435.	cyclopamine	52-63	GLI family zinc finger 1	Homo sapiens	85-88
16855373-10	2006	These results demonstrate modulation of GLI-mediated transcription in both cancer and benign-derived epithelial cells by cyclopamine and sonic hedgehog, and further suggest that hedgehog signaling contributes to the survival of only the cancer epithelial cells.	cyclopamine	121-132	GLI family zinc finger 1	Homo sapiens	40-43
16616798-5	2006	Cells expressing GLI1 responded only weakly to both cyclopamine and RNA interference, suggesting that HH signaling plays only a minor role in the growth of SCLC cell lines.	cyclopamine	52-63	GLI family zinc finger 1	Homo sapiens	17-21
16278368-4	2006	The former was achieved by microarray analysis of Shh expression in all segments of the mouse epididymis, and the latter was determined by 14-day administration of cyclopamine, a Shh pathway inhibitor, followed by a microassay for the activation and duration of cauda epididymal sperm motility.	cyclopamine	164-175	sonic hedgehog	Mus musculus	179-182
16278368-7	2006	Cyclopamine treatment reduced Gli1 expression by 61% and initiation of cauda sperm motility by 50%.	cyclopamine	0-11	GLI-Kruppel family member GLI1	Mus musculus	30-34
16407756-2	2006	Here, we show that Shh accelerates inner ear progenitor cell proliferation, and the inhibitor of Shh signaling cyclopamine reduces mitotic growth of otocyst cells in vitro.	cyclopamine	111-122	sonic hedgehog	Mus musculus	97-100
16407756-4	2006	When Shh signaling was blocked with cyclopamine, hair cell generation was largely inhibited.	cyclopamine	36-47	sonic hedgehog	Mus musculus	5-8
16136078-3	2005	This ciliary expression is regulated by Hh pathway activity; Sonic hedgehog or activating mutations in Smo promote ciliary localization, whereas the Smo antagonist cyclopamine inhibits ciliary localization.	cyclopamine	164-175	smoothened, frizzled class receptor	Homo sapiens	149-152
15652709-4	2005	Moreover, human tumor cells require sustained Hh-Gli signaling for proliferation as cyclopamine, an alkaloid of the lily Veratrum californicum that blocks the Hh pathway, inhibits the growth of different tumor cells in vitro as well as in subcutaneous xenografts.	cyclopamine	84-95	GLI family zinc finger 1	Homo sapiens	49-52
16003493-6	2005	These effects of Shh are reversed by simultaneous administration of cyclopamine, a specific inhibitor of the Shh pathway.	cyclopamine	68-79	sonic hedgehog	Mus musculus	17-20
16003493-6	2005	These effects of Shh are reversed by simultaneous administration of cyclopamine, a specific inhibitor of the Shh pathway.	cyclopamine	68-79	sonic hedgehog	Mus musculus	109-112
15829524-6	2005	Using organ cultures and cyclopamine treatment, we showed downregulation of COUP-TFII level in the stomach, suggesting COUP-TFII as a target of hedgehog signaling in the stomach.	cyclopamine	25-36	nuclear receptor subfamily 2, group F, member 2	Mus musculus	76-85
15829524-6	2005	Using organ cultures and cyclopamine treatment, we showed downregulation of COUP-TFII level in the stomach, suggesting COUP-TFII as a target of hedgehog signaling in the stomach.	cyclopamine	25-36	nuclear receptor subfamily 2, group F, member 2	Mus musculus	119-128
15652709-8	2005	Analyses of the cerebella of cyclopamine-treated animals show a severe reduction in tumor size and a large decrease in the number of Ptc1-expressing cells, as a readout of cells with an active Hu-Gli pathway, as well as an impairment of their proliferative capacity, always in comparison with vehicle treated mice.	cyclopamine	29-40	patched 1	Mus musculus	133-137
15652709-8	2005	Analyses of the cerebella of cyclopamine-treated animals show a severe reduction in tumor size and a large decrease in the number of Ptc1-expressing cells, as a readout of cells with an active Hu-Gli pathway, as well as an impairment of their proliferative capacity, always in comparison with vehicle treated mice.	cyclopamine	29-40	GLI family zinc finger 1	Homo sapiens	196-199
16121254-10	2005	Inhibiting Hh activity by cyclopamine rescues uki and lep mutants and confirms the overactivation of the Hh signaling pathway in these mutants.	cyclopamine	26-37	leptin a	Danio rerio	54-57
15938717-6	2005	To substantiate this possibility, we inhibited induction of the motor neurons in the cultured mouse embryos by cyclopamine, a Shh signaling blocker.	cyclopamine	111-122	sonic hedgehog	Mus musculus	126-129
15938717-8	2005	Expression of Ang-1, but not VEGF, within the neural tube was remarkably reduced in the cyclopamine treated embryos.	cyclopamine	88-99	angiopoietin 1	Mus musculus	14-19
15691835-10	2005	Identical results were observed in the presence of the Shh signal transduction pathway inhibitor, cyclopamine.	cyclopamine	98-109	sonic hedgehog signaling molecule	Canis lupus familiaris	55-58
15652709-7	2005	We find that systemic cyclopamine administration improves the health of Ptc1(+/-);p53(-/-) animals.	cyclopamine	22-33	patched 1	Mus musculus	72-76
15652709-7	2005	We find that systemic cyclopamine administration improves the health of Ptc1(+/-);p53(-/-) animals.	cyclopamine	22-33	transformation related protein 53, pseudogene	Mus musculus	82-85
15618519-6	2004	A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of beta-arrestin 2 with Smo.	cyclopamine	47-58	smoothened, frizzled class receptor	Homo sapiens	31-34
15618519-6	2004	A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of beta-arrestin 2 with Smo.	cyclopamine	47-58	smoothened, frizzled class receptor	Homo sapiens	31-34
15482598-13	2004	In addition, cancer cells expressing Gli1 under the CMV promoter are resistant to cyclopamine-mediated apoptosis.	cyclopamine	82-93	GLI family zinc finger 1	Homo sapiens	37-41
15618519-6	2004	A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of beta-arrestin 2 with Smo.	cyclopamine	47-58	G protein-coupled receptor kinase 2	Homo sapiens	101-105
15618519-6	2004	A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of beta-arrestin 2 with Smo.	cyclopamine	47-58	arrestin beta 2	Homo sapiens	125-140
15618519-6	2004	A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of beta-arrestin 2 with Smo.	cyclopamine	47-58	smoothened, frizzled class receptor	Homo sapiens	31-34
15581865-5	2004	The Shh signaling pathway was disrupted with addition of cyclopamine, jervine, or the 5E1 blocking antibody.	cyclopamine	57-68	sonic hedgehog signaling molecule	Rattus norvegicus	4-7
15464577-4	2004	The induction of the more ventral phenotype was due to the higher expression level of the N-terminus of sonic hedgehog protein (Shh-N) when treated with low concentration RA, as it was abrogated by an inhibitor of Shh signaling, cyclopamine.	cyclopamine	229-240	sonic hedgehog	Mus musculus	104-126
15492281-3	2004	We report here that chronic oral administration of cyclopamine dramatically reduces ( approximately 66%) UVB induced basal cell carcinoma formation in Ptch1(+/-) mice.	cyclopamine	51-62	patched 1	Mus musculus	151-156
15492281-4	2004	Fas expression is low in human and murine basal cell carcinomas but is up-regulated in the presence of the smoothened (SMO) antagonist, cyclopamine, both in vitro in the mouse basal cell carcinoma cell line ASZ001 and in vivo after acute treatment of mice with basal cell carcinomas.	cyclopamine	136-147	smoothened, frizzled class receptor	Mus musculus	107-117
15492281-4	2004	Fas expression is low in human and murine basal cell carcinomas but is up-regulated in the presence of the smoothened (SMO) antagonist, cyclopamine, both in vitro in the mouse basal cell carcinoma cell line ASZ001 and in vivo after acute treatment of mice with basal cell carcinomas.	cyclopamine	136-147	smoothened, frizzled class receptor	Mus musculus	119-122
15492281-7	2004	Fas/Fas ligand interactions are necessary for cyclopamine-mediated apoptosis in these cells, a process involving caspase-8 activation.	cyclopamine	46-57	caspase 8	Mus musculus	113-122
15492281-8	2004	Our data provide strong evidence that cyclopamine and perhaps other SMO antagonists are potent in vivo inhibitors of UVB-induced basal cell carcinomas in Ptch1(+/-) mice and likely in humans because the majority of human basal cell carcinomas manifest mutations in PTCH1 and that a major mechanism of their inhibitory effect is through up-regulation of Fas, which augments apoptosis.	cyclopamine	38-49	smoothened, frizzled class receptor	Mus musculus	68-71
15492281-8	2004	Our data provide strong evidence that cyclopamine and perhaps other SMO antagonists are potent in vivo inhibitors of UVB-induced basal cell carcinomas in Ptch1(+/-) mice and likely in humans because the majority of human basal cell carcinomas manifest mutations in PTCH1 and that a major mechanism of their inhibitory effect is through up-regulation of Fas, which augments apoptosis.	cyclopamine	38-49	patched 1	Mus musculus	154-159
15492281-8	2004	Our data provide strong evidence that cyclopamine and perhaps other SMO antagonists are potent in vivo inhibitors of UVB-induced basal cell carcinomas in Ptch1(+/-) mice and likely in humans because the majority of human basal cell carcinomas manifest mutations in PTCH1 and that a major mechanism of their inhibitory effect is through up-regulation of Fas, which augments apoptosis.	cyclopamine	38-49	patched 1	Homo sapiens	265-270
15356205-6	2004	Finally, the pharmacological inhibitor of Shh signaling, cyclopamine, induces motor neuron death in adult rats after axotomy.	cyclopamine	57-68	sonic hedgehog signaling molecule	Rattus norvegicus	42-45
15342389-9	2004	Exposure to cyclopamine, a steroidal alkaloid that blocks the Hh pathway, suppresses expression of Gli1 and the growth of the Hh pathway-activated breast carcinoma cells.	cyclopamine	12-23	GLI family zinc finger 1	Homo sapiens	99-103
15314219-4	2004	Blocking the pathway with cyclopamine or anti-SHH antibodies inhibits the proliferation of GLI1+/PSA+ primary prostate tumor cultures.	cyclopamine	26-37	GLI family zinc finger 1	Homo sapiens	91-95
15314219-6	2004	In addition, pathway blockade in three metastatic prostate cancer cell lines with cyclopamine or through GLI1 RNA interference leads to inhibition of cell proliferation, suggesting cell-autonomous pathway activation at different levels and showing an essential role for GLI1 in human cells.	cyclopamine	82-93	GLI family zinc finger 1	Homo sapiens	270-274
15042696-8	2004	Furthermore, by using cyclopamine, a steroidal alkaloid that specifically disrupts the Shh pathway, to abrogate endogenous Shh signaling in vitro, we found a significant decrease in branching in cyclopamine-treated explants compared with controls, as well as a significant decrease in epithelial cell proliferation.	cyclopamine	22-33	sonic hedgehog	Mus musculus	87-90
15136151-4	2004	In Shh(-/-) or cyclopamine-treated wild-type (WT) lung, we found that Gli3R level is elevated, and this upregulation appears to contribute to defects in proliferation and differentiation observed in the Shh(-/-) mesenchyme, where Gli3 is normally expressed.	cyclopamine	15-26	sonic hedgehog	Mus musculus	203-206
15136151-4	2004	In Shh(-/-) or cyclopamine-treated wild-type (WT) lung, we found that Gli3R level is elevated, and this upregulation appears to contribute to defects in proliferation and differentiation observed in the Shh(-/-) mesenchyme, where Gli3 is normally expressed.	cyclopamine	15-26	GLI-Kruppel family member GLI3	Mus musculus	70-74
15042696-8	2004	Furthermore, by using cyclopamine, a steroidal alkaloid that specifically disrupts the Shh pathway, to abrogate endogenous Shh signaling in vitro, we found a significant decrease in branching in cyclopamine-treated explants compared with controls, as well as a significant decrease in epithelial cell proliferation.	cyclopamine	22-33	sonic hedgehog	Mus musculus	123-126
15042696-8	2004	Furthermore, by using cyclopamine, a steroidal alkaloid that specifically disrupts the Shh pathway, to abrogate endogenous Shh signaling in vitro, we found a significant decrease in branching in cyclopamine-treated explants compared with controls, as well as a significant decrease in epithelial cell proliferation.	cyclopamine	195-206	sonic hedgehog	Mus musculus	87-90
15042696-8	2004	Furthermore, by using cyclopamine, a steroidal alkaloid that specifically disrupts the Shh pathway, to abrogate endogenous Shh signaling in vitro, we found a significant decrease in branching in cyclopamine-treated explants compared with controls, as well as a significant decrease in epithelial cell proliferation.	cyclopamine	195-206	sonic hedgehog	Mus musculus	123-126
15042696-10	2004	Exogenous FGF8 peptide supplementation in vitro rescues the abnormal SMG phenotype seen in cyclopamine-treated explants, demonstrating that overexpression of a parallel, but related, downstream signaling pathway can compensate for diminished Shh signaling and restore embryonic SMG branching morphogenesis.	cyclopamine	91-102	fibroblast growth factor 8	Mus musculus	10-14
15042696-10	2004	Exogenous FGF8 peptide supplementation in vitro rescues the abnormal SMG phenotype seen in cyclopamine-treated explants, demonstrating that overexpression of a parallel, but related, downstream signaling pathway can compensate for diminished Shh signaling and restore embryonic SMG branching morphogenesis.	cyclopamine	91-102	sonic hedgehog	Mus musculus	242-245
15013214-6	2004	The requirement for SHH-Gli signaling in the growth of the mouse brain, together with the ability of inappropriate pathway activation in the cerebellum to cause medulloblastomas, and the inhibition of the growth of a number of brain tumors with cyclopamine, a SHH signaling inhibitor, underscores the critical role of the SHH-GLI pathway in brain growth and tumor formation.	cyclopamine	245-256	sonic hedgehog	Mus musculus	20-23
14651923-3	2003	Prostatic budding was induced in response to testosterone in Shh null mouse urogenital sinus (UGS) explants grown in vitro and in rat UGS explants cultured with cyclopamine, suggesting that SHH-signalling is not critical for prostatic induction.	cyclopamine	161-172	sonic hedgehog signaling molecule	Rattus norvegicus	190-193
14764995-3	2004	Two recent reports in Nature suggest that Sonic Hedgehog (Shh) overexpression may contribute to pancreatic tumorigenesis and that cyclopamine, a specific inhibitor of Shh signaling, can reduce pancreatic cancer cell growth and viability.	cyclopamine	130-141	sonic hedgehog signaling molecule	Homo sapiens	167-170
14733907-4	2004	One of the Shh-expressing OSCC cell lines HSQ-89 showed the inhibition of G1/S transition and apoptotic cell death by treatment with Cyclopamine, a steroidal alkaloid that blocks the intracellular Shh signaling.	cyclopamine	133-144	sonic hedgehog signaling molecule	Homo sapiens	11-14
14733907-4	2004	One of the Shh-expressing OSCC cell lines HSQ-89 showed the inhibition of G1/S transition and apoptotic cell death by treatment with Cyclopamine, a steroidal alkaloid that blocks the intracellular Shh signaling.	cyclopamine	133-144	sonic hedgehog signaling molecule	Homo sapiens	197-200
12828684-3	2003	In the early stage of follicle development, the downward growth of the follicular epithelium was suppressed by cyclopamine, an inhibitor of Shh signaling, and accelerated by recombinant Shh.	cyclopamine	111-122	sonic hedgehog	Mus musculus	140-143
12921735-6	2003	In addition, misexpression of XPtc1deltaLoop2 as well as treatment of Xenopus embryos with the specific Hh signaling antagonist cyclopamine resulted in the formation of enlarged otic vesicles.	cyclopamine	128-139	sonic hedgehog L homeolog	Xenopus laevis	104-106
14678849-10	2003	In contrast, the BMP-induced differentiation of KS483 cells could only be partly inhibited by high doses of cyclopamine.	cyclopamine	108-119	bone morphogenetic protein 1	Homo sapiens	17-20
14660548-5	2003	Furthermore, neurospheres generated from SHH null mice also produced oligodendrocytes, even in the presence of cyclopamine.	cyclopamine	111-122	sonic hedgehog	Mus musculus	41-44
13129844-4	2003	Blocking Hh pathway activation at later stages of embryogenesis with the steroidal alkaloid, cyclopamine, further reveals that the requirement for a Hh signal response in DRG precursors correlates with the onset of ngn1 expression.	cyclopamine	93-104	collagen, type IV, alpha 5 (Alport syndrome)	Danio rerio	171-174
13129844-4	2003	Blocking Hh pathway activation at later stages of embryogenesis with the steroidal alkaloid, cyclopamine, further reveals that the requirement for a Hh signal response in DRG precursors correlates with the onset of ngn1 expression.	cyclopamine	93-104	neurogenin 1	Danio rerio	215-219
12889063-5	2003	The promotion of ngn-1 expression by Shh, furthermore, was inhibited by cyclopamine, a specific inhibitor of Shh signaling.	cyclopamine	72-83	neurogenin 1	Homo sapiens	17-22
12889063-5	2003	The promotion of ngn-1 expression by Shh, furthermore, was inhibited by cyclopamine, a specific inhibitor of Shh signaling.	cyclopamine	72-83	sonic hedgehog signaling molecule	Homo sapiens	37-40
12889063-5	2003	The promotion of ngn-1 expression by Shh, furthermore, was inhibited by cyclopamine, a specific inhibitor of Shh signaling.	cyclopamine	72-83	sonic hedgehog signaling molecule	Homo sapiens	109-112
12743812-7	2003	Furthermore, using cyclopamine, we have demonstrated that IGFBP-5 expression in the early embryo is regulated by Shh.	cyclopamine	19-30	insulin like growth factor binding protein 5	Gallus gallus	58-65
12743812-7	2003	Furthermore, using cyclopamine, we have demonstrated that IGFBP-5 expression in the early embryo is regulated by Shh.	cyclopamine	19-30	sonic hedgehog	Gallus gallus	113-116
12648489-7	2003	Tongues cultured with cyclopamine have a dose-dependent expansion of Shh and BMP4(LacZ) expression domains.	cyclopamine	22-33	sonic hedgehog	Mus musculus	69-72
12679031-5	2003	Cyclopamine-mediated inhibition of the Shh signaling mediator Smoothened (Smo) or conditional inactivation of Smo in commissural neurons indicate that Smo activity is important for the additional chemoattractant activity of the floor plate in vitro and for the normal projection of commissural axons to the floor plate in vivo.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	39-42
12679031-5	2003	Cyclopamine-mediated inhibition of the Shh signaling mediator Smoothened (Smo) or conditional inactivation of Smo in commissural neurons indicate that Smo activity is important for the additional chemoattractant activity of the floor plate in vitro and for the normal projection of commissural axons to the floor plate in vivo.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	62-72
12679031-5	2003	Cyclopamine-mediated inhibition of the Shh signaling mediator Smoothened (Smo) or conditional inactivation of Smo in commissural neurons indicate that Smo activity is important for the additional chemoattractant activity of the floor plate in vitro and for the normal projection of commissural axons to the floor plate in vivo.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	62-65
12679031-5	2003	Cyclopamine-mediated inhibition of the Shh signaling mediator Smoothened (Smo) or conditional inactivation of Smo in commissural neurons indicate that Smo activity is important for the additional chemoattractant activity of the floor plate in vitro and for the normal projection of commissural axons to the floor plate in vivo.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	74-77
12679031-5	2003	Cyclopamine-mediated inhibition of the Shh signaling mediator Smoothened (Smo) or conditional inactivation of Smo in commissural neurons indicate that Smo activity is important for the additional chemoattractant activity of the floor plate in vitro and for the normal projection of commissural axons to the floor plate in vivo.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	74-77
12648489-7	2003	Tongues cultured with cyclopamine have a dose-dependent expansion of Shh and BMP4(LacZ) expression domains.	cyclopamine	22-33	bone morphogenetic protein 4	Mus musculus	77-81
12606278-0	2003	Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium.	cyclopamine	0-11	sonic hedgehog signaling molecule	Rattus norvegicus	80-83
12514186-8	2003	Shh rapidly increased PI3-kinase activity in IBE cells and HUVECs; this activity was inhibited by cyclopamine.	cyclopamine	98-109	sonic hedgehog	Mus musculus	0-3
12606278-10	2003	The Shh protein was in all fungiform papillae in embryonic tongues, and tongue cultures with standard medium or cyclopamine, and was conspicuously localized in the basement membrane region of the papillae.	cyclopamine	112-123	sonic hedgehog signaling molecule	Rattus norvegicus	4-7
12606279-6	2003	Later (15-20 h) cyclopamine treatments disrupt anterior expression of nk2.2 and Prolactin, showing that early functional patterning requires Hh signals.	cyclopamine	16-27	NK2 homeobox 2a	Danio rerio	70-75
12221011-8	2002	Nonetheless, the chemical inhibitor of Shh signaling, cyclopamine, produced a graded inhibition of Gli gene expression (Gli1>Gli2>Gli3) in urogenital sinus explants that was paralleled by a severe inhibition of ductal budding.	cyclopamine	54-65	sonic hedgehog signaling molecule	Homo sapiens	39-42
12469128-6	2003	Finally, the pharmacological inhibitor of Shh signaling cyclopamine reduced hippocampal neural progenitor proliferation in vivo.	cyclopamine	56-67	sonic hedgehog signaling molecule	Rattus norvegicus	42-45
12414725-0	2002	Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.	cyclopamine	54-65	smoothened, frizzled class receptor	Homo sapiens	69-79
12414725-2	2002	We show here, using photoaffinity and fluorescent derivatives, that this inhibitory effect is mediated by direct binding of cyclopamine to the heptahelical bundle of Smoothened (Smo).	cyclopamine	124-135	smoothened, frizzled class receptor	Homo sapiens	166-176
12414725-2	2002	We show here, using photoaffinity and fluorescent derivatives, that this inhibitory effect is mediated by direct binding of cyclopamine to the heptahelical bundle of Smoothened (Smo).	cyclopamine	124-135	smoothened, frizzled class receptor	Homo sapiens	166-169
12414725-3	2002	Cyclopamine also can reverse the retention of partially misfolded Smo in the endoplasmic reticulum, presumably through binding-mediated effects on protein conformation.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	66-69
12414725-4	2002	These observations reveal the mechanism of cyclopamine"s teratogenic and antitumor activities and further suggest a role for small molecules in the physiological regulation of Smo.	cyclopamine	43-54	smoothened, frizzled class receptor	Homo sapiens	176-179
12391318-3	2002	Here we demonstrate that SAG, a chlorobenzothiophene-containing Hh pathway agonist, binds to the Smo heptahelical bundle in a manner that antagonizes cyclopamine action.	cyclopamine	150-161	S-antigen visual arrestin	Homo sapiens	25-28
12391318-3	2002	Here we demonstrate that SAG, a chlorobenzothiophene-containing Hh pathway agonist, binds to the Smo heptahelical bundle in a manner that antagonizes cyclopamine action.	cyclopamine	150-161	smoothened, frizzled class receptor	Homo sapiens	97-100
12537426-4	2003	Cyclopamine (1) and jervine (2) are potent teratogens that inhibit Sonic hedgehog (Shh) signaling during gastrulation-stage embryonic development, producing cyclopia and holoprosencephaly.	cyclopamine	0-11	sonic hedgehog homolog	Ovis aries	67-81
12537426-4	2003	Cyclopamine (1) and jervine (2) are potent teratogens that inhibit Sonic hedgehog (Shh) signaling during gastrulation-stage embryonic development, producing cyclopia and holoprosencephaly.	cyclopamine	0-11	sonic hedgehog homolog	Ovis aries	83-86
12391318-2	2002	Although the cellular mechanisms that regulate Smo function remain unclear, the direct inhibition of Smo by cyclopamine, a plant-derived steroidal alkaloid, suggests that endogenous small molecules may be involved.	cyclopamine	108-119	smoothened, frizzled class receptor	Homo sapiens	101-104
12221011-8	2002	Nonetheless, the chemical inhibitor of Shh signaling, cyclopamine, produced a graded inhibition of Gli gene expression (Gli1>Gli2>Gli3) in urogenital sinus explants that was paralleled by a severe inhibition of ductal budding.	cyclopamine	54-65	GLI family zinc finger 1	Homo sapiens	99-102
12221011-8	2002	Nonetheless, the chemical inhibitor of Shh signaling, cyclopamine, produced a graded inhibition of Gli gene expression (Gli1>Gli2>Gli3) in urogenital sinus explants that was paralleled by a severe inhibition of ductal budding.	cyclopamine	54-65	GLI family zinc finger 1	Homo sapiens	120-124
12221011-8	2002	Nonetheless, the chemical inhibitor of Shh signaling, cyclopamine, produced a graded inhibition of Gli gene expression (Gli1>Gli2>Gli3) in urogenital sinus explants that was paralleled by a severe inhibition of ductal budding.	cyclopamine	54-65	GLI family zinc finger 2	Homo sapiens	128-132
12221011-8	2002	Nonetheless, the chemical inhibitor of Shh signaling, cyclopamine, produced a graded inhibition of Gli gene expression (Gli1>Gli2>Gli3) in urogenital sinus explants that was paralleled by a severe inhibition of ductal budding.	cyclopamine	54-65	GLI family zinc finger 3	Homo sapiens	136-140
11493571-8	2001	However, OLPs did develop in cultures of Nkx2.1(-/-) basal forebrain and this was blocked by cyclopamine.	cyclopamine	93-104	NK2 homeobox 1	Mus musculus	41-47
12217316-6	2002	By in vivo notochord grafting and cyclopamine treatment, we demonstrate that the spatially restricted pattern of GATA3 expression is regulated, at least in part, by the signaling molecule Sonic hedgehog.	cyclopamine	34-45	GATA binding protein 3	Gallus gallus	113-118
12060710-6	2002	We disrupted shh signaling in the regenerating fin by exposure to cyclopamine and found a dose-dependent inhibition of fin outgrowth, accumulation of melanocytes in the distal region of each fin ray, loss of actinotrichia, and reduction in cell proliferation in the mesenchyme.	cyclopamine	66-77	sonic hedgehog signaling molecule a	Danio rerio	13-16
11900460-4	2002	Using cyclopamine to inhibit hedgehog signaling, we show that transient Shh signaling is necessary during gastrulation for subsequent differentiation of endoderm into islet tissue.	cyclopamine	6-17	sonic hedgehog signaling molecule a	Danio rerio	72-75
11788837-5	2002	Normal midbrain expansion was restored by implantation of Shh-secreting cells in a dose-dependent manner; conversely, expansion was retarded following antagonism of the Shh signaling pathway by cyclopamine.	cyclopamine	194-205	sonic hedgehog signaling molecule	Homo sapiens	169-172
11748155-5	2001	We also show that a variety of primary human brain tumors and tumor lines consistently express the GLI genes and that cyclopamine, a SHH signaling inhibitor, inhibits the proliferation of tumor cells.	cyclopamine	118-129	sonic hedgehog signaling molecule	Homo sapiens	133-136
11487541-7	2001	In cyclopamine-treated mice, we observed decreased expression of HNF3beta, Islet (Isl)-1 and BMP4, 3 putative Shh target genes.	cyclopamine	3-14	bone morphogenetic protein 4	Mus musculus	93-97
11487541-7	2001	In cyclopamine-treated mice, we observed decreased expression of HNF3beta, Islet (Isl)-1 and BMP4, 3 putative Shh target genes.	cyclopamine	3-14	sonic hedgehog	Mus musculus	110-113
11965540-6	2002	Cyclopamine, a specific inhibitor of the Shh/Ptc/Smo signaling pathway, efficiently suppressed anchorage independent growth of A431 and KA cells.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	41-44
11965540-6	2002	Cyclopamine, a specific inhibitor of the Shh/Ptc/Smo signaling pathway, efficiently suppressed anchorage independent growth of A431 and KA cells.	cyclopamine	0-11	smoothened, frizzled class receptor	Homo sapiens	49-52
11714677-4	2001	We manipulated chondrocyte differentiation by supplementing these cultures either with BMP2, PTHrP and Sonic hedgehog as activators or with Noggin and cyclopamine as inhibitors of the BMP and Ihh/PTHrP signaling systems.	cyclopamine	151-162	parathyroid hormone-like peptide	Mus musculus	196-201
11694189-6	2001	This acceleration was suppressed by the addition of cyclopamine, a specific inhibitor of Shh signaling.	cyclopamine	52-63	sonic hedgehog signaling molecule	Homo sapiens	89-92
11487541-5	2001	Mice were treated with the Shh inhibitor cyclopamine and examined for expression levels of Shh targets and proliferation of gastric epithelial cells.	cyclopamine	41-52	sonic hedgehog	Mus musculus	27-30
11487541-7	2001	In cyclopamine-treated mice, we observed decreased expression of HNF3beta, Islet (Isl)-1 and BMP4, 3 putative Shh target genes.	cyclopamine	3-14	forkhead box A2	Mus musculus	65-73
11487541-7	2001	In cyclopamine-treated mice, we observed decreased expression of HNF3beta, Islet (Isl)-1 and BMP4, 3 putative Shh target genes.	cyclopamine	3-14	ISL1 transcription factor, LIM/homeodomain	Mus musculus	75-88
11493557-6	2001	Blocking maternal hedgehog signaling by cyclopamine eliminates primary motoneurons, but not medial floor plate.	cyclopamine	40-51	hedgehog	Drosophila melanogaster	18-26
11181516-7	2001	Addition of cyclopamine to INS-1 cells decreased IDX-1 messenger RNA expression.	cyclopamine	12-23	pancreatic and duodenal homeobox 1	Rattus norvegicus	49-54
11181516-8	2001	In transient transfections of a -4.5-kb mouse IDX-1 promoter-reporter construct, ectopic Hh expression increased (and cyclopamine administration decreased) transcriptional activation of the IDX-1 promoter in a dose-dependent manner.	cyclopamine	118-129	pancreatic and duodenal homeobox 1	Mus musculus	46-51
11181516-8	2001	In transient transfections of a -4.5-kb mouse IDX-1 promoter-reporter construct, ectopic Hh expression increased (and cyclopamine administration decreased) transcriptional activation of the IDX-1 promoter in a dose-dependent manner.	cyclopamine	118-129	pancreatic and duodenal homeobox 1	Mus musculus	190-195
9882493-6	1999	Despite the profound inhibition of hair follicle morphogenesis, late-stage follicle differentiation markers were detected in Shh -/- skin grafts, as well as cultured vibrissa explants treated with cyclopamine to block Shh signaling.	cyclopamine	197-208	sonic hedgehog signaling molecule	Homo sapiens	218-221
11118005-6	2000	The administration of cyclopamine, a Hh signaling inhibitor, decreases both insulin secretion from and insulin content of INS-1 cells.	cyclopamine	22-33	insulin 1	Rattus norvegicus	122-127
11118005-9	2000	Furthermore, the treatment of INS-1 cells with cyclopamine diminishes endogenous insulin mRNA expression.	cyclopamine	47-58	insulin 1	Rattus norvegicus	30-35
10984056-0	2000	Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.	cyclopamine	76-87	smoothened, frizzled class receptor	Homo sapiens	34-44
10984056-0	2000	Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.	cyclopamine	76-87	patched 1	Homo sapiens	49-56
10984056-5	2000	Our results also indicate that cyclopamine may act by influencing the balance between active and inactive forms of Smoothened.	cyclopamine	31-42	smoothened, frizzled class receptor	Homo sapiens	115-125
10926779-0	2000	Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	26-40
10926779-1	2000	Cyclopamine is a teratogenic steroidal alkaloid that causes cyclopia by blocking Sonic hedgehog (Shh) signal transduction.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	81-95
10926779-1	2000	Cyclopamine is a teratogenic steroidal alkaloid that causes cyclopia by blocking Sonic hedgehog (Shh) signal transduction.	cyclopamine	0-11	sonic hedgehog signaling molecule	Homo sapiens	97-100
10926779-3	2000	First, we report that the potent antagonism of Shh signaling by cyclopamine is not a general property of steroidal alkaloids with similar structure.	cyclopamine	64-75	sonic hedgehog signaling molecule	Homo sapiens	47-50
10751185-7	2000	(3) Sonic hedgehog (Shh) is expressed in endodermal epithelium and disruption of Shh-signaling by cyclopamine induces differentiation of smooth muscle and a large number of neurons even in the area adjacent to epithelium.	cyclopamine	98-109	sonic hedgehog signaling molecule	Homo sapiens	4-18
10751185-7	2000	(3) Sonic hedgehog (Shh) is expressed in endodermal epithelium and disruption of Shh-signaling by cyclopamine induces differentiation of smooth muscle and a large number of neurons even in the area adjacent to epithelium.	cyclopamine	98-109	sonic hedgehog signaling molecule	Homo sapiens	81-84
11130177-2	2000	Other causes of holoprosencephaly have converged upon the Shh signaling pathway: genetic and pharmacologic impairment of cholesterol synthesis, and the action of the steroidal alkaloid cyclopamine.	cyclopamine	185-196	sonic hedgehog signaling molecule	Homo sapiens	58-61
11130177-7	2000	The similarity of the Shh receptor, Patched (Ptc), to the Niemann-Pick Cl protein, which is involved in the vesicular trafficking of cholesterol, provides insight into the role of cholesterol and the action of compounds like cyclopamine.	cyclopamine	225-236	sonic hedgehog signaling molecule	Homo sapiens	22-25
11042037-8	2000	Incubation of hematopoietic progenitors with Shh-N and GM-CSF resulted in increased granulocyte/monocyte colonies (P < 0.01); the increase was blocked by cyclopamine.	cyclopamine	157-168	sonic hedgehog signaling molecule	Homo sapiens	45-48
11042037-8	2000	Incubation of hematopoietic progenitors with Shh-N and GM-CSF resulted in increased granulocyte/monocyte colonies (P < 0.01); the increase was blocked by cyclopamine.	cyclopamine	157-168	colony stimulating factor 2	Homo sapiens	55-61
33772412-6	2021	However, the therapeutic effect of rSIRT1 was reversed by cyclopamine.	cyclopamine	58-69	sirtuin 1	Rattus norvegicus	35-41
9789036-0	1998	Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor.	cyclopamine	36-47	sonic hedgehog signaling molecule	Homo sapiens	51-59
9789036-1	1998	Exposure to cyclopamine, a steroid alkaloid that blocks Sonic hedgehog (Shh) signaling, promotes pancreatic expansion in embryonic chicks.	cyclopamine	12-23	sonic hedgehog signaling molecule	Homo sapiens	56-70
9789036-1	1998	Exposure to cyclopamine, a steroid alkaloid that blocks Sonic hedgehog (Shh) signaling, promotes pancreatic expansion in embryonic chicks.	cyclopamine	12-23	sonic hedgehog signaling molecule	Homo sapiens	72-75
9789036-4	1998	The results suggests that cyclopamine expands the endodermal region where Shh signaling does not occur, resulting in pancreatic differentiation in a larger region of PDX1-expressing foregut endoderm.	cyclopamine	26-37	sonic hedgehog signaling molecule	Homo sapiens	74-77
9789036-4	1998	The results suggests that cyclopamine expands the endodermal region where Shh signaling does not occur, resulting in pancreatic differentiation in a larger region of PDX1-expressing foregut endoderm.	cyclopamine	26-37	pancreatic and duodenal homeobox 1	Homo sapiens	166-170
9716521-0	1998	The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.	cyclopamine	34-45	sonic hedgehog	Gallus gallus	55-69
9716521-2	1998	Cyclopamine-induced malformations in chick embryos are associated with interruption of Sonic hedgehog (Shh)-mediated dorsoventral patterning of the neural tube and somites.	cyclopamine	0-11	sonic hedgehog	Gallus gallus	87-101
9716521-2	1998	Cyclopamine-induced malformations in chick embryos are associated with interruption of Sonic hedgehog (Shh)-mediated dorsoventral patterning of the neural tube and somites.	cyclopamine	0-11	sonic hedgehog	Gallus gallus	103-106
9716521-4	1998	Somites in cyclopamine-treated embryos show Pax7 expression throughout, indicating failure of sclerotome induction.	cyclopamine	11-22	paired box 7	Gallus gallus	44-48
9716521-5	1998	Cyclopamine at concentrations of 20-100 nM blocks the response of neural plate explants to recombinant Shh-N in a dose-dependent manner.	cyclopamine	0-11	sonic hedgehog	Gallus gallus	103-106
9716521-11	1998	These findings suggest that cyclopamine-induced teratogenesis is due to a more direct antagonism of Shh signal transduction.	cyclopamine	28-39	sonic hedgehog	Gallus gallus	100-103
34816492-7	2022	Furthermore, we found that mkxa-/- zebrafish were more susceptible than mkxa+/+ zebrafish to the deleterious effects of cyclopamine, an inhibitor of SHH signaling, on upper jaw development.	cyclopamine	120-131	mohawk homeobox a	Danio rerio	27-31
34816492-7	2022	Furthermore, we found that mkxa-/- zebrafish were more susceptible than mkxa+/+ zebrafish to the deleterious effects of cyclopamine, an inhibitor of SHH signaling, on upper jaw development.	cyclopamine	120-131	mohawk homeobox a	Danio rerio	72-76
34816492-7	2022	Furthermore, we found that mkxa-/- zebrafish were more susceptible than mkxa+/+ zebrafish to the deleterious effects of cyclopamine, an inhibitor of SHH signaling, on upper jaw development.	cyclopamine	120-131	sonic hedgehog signaling molecule a	Danio rerio	149-152
34905501-7	2021	Furthermore, TLR4 signaling was also activated after IGFBP-6 and purmorphamine exposure and reverted by cyclopamine exposure, an inhibitor of the SHH pathway, confirming that SHH is involved in TLR4 activation and microenvironment alterations.	cyclopamine	104-115	toll like receptor 4	Homo sapiens	13-17
34905501-7	2021	Furthermore, TLR4 signaling was also activated after IGFBP-6 and purmorphamine exposure and reverted by cyclopamine exposure, an inhibitor of the SHH pathway, confirming that SHH is involved in TLR4 activation and microenvironment alterations.	cyclopamine	104-115	sonic hedgehog signaling molecule	Homo sapiens	146-149
34905501-7	2021	Furthermore, TLR4 signaling was also activated after IGFBP-6 and purmorphamine exposure and reverted by cyclopamine exposure, an inhibitor of the SHH pathway, confirming that SHH is involved in TLR4 activation and microenvironment alterations.	cyclopamine	104-115	sonic hedgehog signaling molecule	Homo sapiens	175-178
34905501-7	2021	Furthermore, TLR4 signaling was also activated after IGFBP-6 and purmorphamine exposure and reverted by cyclopamine exposure, an inhibitor of the SHH pathway, confirming that SHH is involved in TLR4 activation and microenvironment alterations.	cyclopamine	104-115	toll like receptor 4	Homo sapiens	194-198