PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22439664-1	2012	Gold nanoparticles (Au NPs) from 5 to 100 nm in size synthesized with HAuCl(4) and sodium citrate were complexed with the plasma protein human serum albumin (HSA).	Sodium Citrate	83-97	albumin	Homo sapiens	143-156
21689719-7	2011	In conclusion, the observed hydrolytic activities of KLK13 and its co-localization with its activators, glycosaminoglycans in the salivary gland and high concentration of sodium citrate in male reproductive tissues, indicates that KLK13 may play a role in the defense of the upper digestive apparatus and in male reproductive organs.	Sodium Citrate	171-185	kallikrein related peptidase 13	Homo sapiens	53-58
21689719-7	2011	In conclusion, the observed hydrolytic activities of KLK13 and its co-localization with its activators, glycosaminoglycans in the salivary gland and high concentration of sodium citrate in male reproductive tissues, indicates that KLK13 may play a role in the defense of the upper digestive apparatus and in male reproductive organs.	Sodium Citrate	171-185	kallikrein related peptidase 13	Homo sapiens	231-236
21600897-0	2011	Inhibition of unfolding and aggregation of lens protein human gamma D crystallin by sodium citrate.	Sodium Citrate	84-98	crystallin gamma D	Homo sapiens	62-80
20800586-5	2010	Effects of different anticoagulants (EDTA, heparin and sodium citrate) on plasma corin levels were examined.	Sodium Citrate	55-69	corin, serine peptidase	Homo sapiens	81-86
20874780-8	2011	We found that a positive result with the beta2GPI-dependent LAC assay correlated better with thrombosis [odds ratio (OR): 3.3, 95% confidence interval (CI) 1.9-5.8] when 0.109 m sodium citrate was used compared with 0.129 m sodium citrate (OR: 0.4, 95% CI 0.1-1.1).	Sodium Citrate	178-192	apolipoprotein H	Homo sapiens	41-49
20874780-8	2011	We found that a positive result with the beta2GPI-dependent LAC assay correlated better with thrombosis [odds ratio (OR): 3.3, 95% confidence interval (CI) 1.9-5.8] when 0.109 m sodium citrate was used compared with 0.129 m sodium citrate (OR: 0.4, 95% CI 0.1-1.1).	Sodium Citrate	224-238	apolipoprotein H	Homo sapiens	41-49
20874780-9	2011	CONCLUSION: We were able to confirm in an international multicenter study that a positive result in a beta2GPI-dependent LAC assay correlates better with thrombosis than the classic LAC assay, but that the assay needs further study as it is sensitive to external factors such as the sodium citrate concentration used as anticoagulant in the test sample.	Sodium Citrate	283-297	apolipoprotein H	Homo sapiens	102-110
20800586-6	2010	RESULTS: Corin levels in serum were similar to that in plasma with heparin (950+-305 vs. 929+-301 pg/ml, n=40, p=0.73), but were significantly higher than those in plasma with sodium citrate (735+-237 pg/ml, p<0.01) or EDTA (716+-261 pg/ml, p<0.001).	Sodium Citrate	176-190	corin, serine peptidase	Homo sapiens	9-14
19881273-5	2009	Freeze-drying of BSA at different concentrations indicated retention of the secondary structure at similar monosodium citrate/protein concentration ratios, suggesting stabilization through direct interaction that substitute water molecules inevitable for the conformation integrity.	Sodium Citrate	107-125	albumin	Bos taurus	17-20
20371359-0	2010	Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans.	Sodium Citrate	106-120	kallikrein related peptidase 3	Homo sapiens	46-76
20371359-0	2010	Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans.	Sodium Citrate	106-120	kallikrein related peptidase 3	Homo sapiens	78-82
20371359-0	2010	Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans.	Sodium Citrate	106-120	kallikrein related peptidase 3	Homo sapiens	86-89
20371359-1	2010	We report the enzymatic properties and substrate specificity of human recombinant KLK3 in the presence of glycosaminoglycans (GAGs) and sodium citrate.	Sodium Citrate	136-150	kallikrein related peptidase 3	Homo sapiens	82-86
20371359-3	2010	In contrast to the latter peptidase, KLK3 activated by sodium citrate efficiently hydrolyzed substrates containing R, H and P at the P1 position.	Sodium Citrate	55-69	kallikrein related peptidase 3	Homo sapiens	37-41
20371359-6	2010	Sodium citrate modulated KLK3 conformation as observed by alterations to the intrinsic fluorescence of phenylalanines and tryptophans.	Sodium Citrate	0-14	kallikrein related peptidase 3	Homo sapiens	25-29
19865650-1	2009	At the aperture of an optical fiber coupled with a SNOM SERRS-active Ag nanoparticles were selectively fabricated in a mixture of AgNO(3) and sodium citrate aqueous solution by photo-reduction due to an evanescent field.	Sodium Citrate	142-156	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	56-61
18714441-7	2008	The virus in a freeze dried fibrinogen containing trisodium citrate dihydrate and l-arginine hydrochloride as stabilizers was inactivated slowly and the LRF was 2.0 and 3.0, respectively, of the 72 h at 60 degrees C, but inactivated to below the detection limit within 24 h at 80 degrees C with an LRF of > or = 4.0.	Sodium Citrate	50-77	CREB3 regulatory factor	Homo sapiens	153-156
19756290-6	2009	In all the cases analysed, the enhancement of both SEF and SERS spectra, is larger for hydroxylamine hydrochloride than that for sodium citrate.	Sodium Citrate	129-143	interleukin 17 receptor D	Homo sapiens	51-54
19756290-6	2009	In all the cases analysed, the enhancement of both SEF and SERS spectra, is larger for hydroxylamine hydrochloride than that for sodium citrate.	Sodium Citrate	129-143	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	59-63
19048790-5	2008	5% Kel and 1% M) with different concentrations of sodium citrate and calcium ion was carried out to select the suitable proportion of calcium ion and sodium citrate.	Sodium Citrate	150-164	Kell metallo-endopeptidase	Canis lupus familiaris	3-6
17655111-8	2007	The SERS of methyl orange has been obtained on the nano-silver colloids, which has not been obtaind on the colloids prepared by electrolysis of silver rod using sodium citrate solution and on the gray and yellow silver colloids prepared by traditional means.	Sodium Citrate	161-175	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	4-8
18560151-1	2008	The structure of the antibody Fab fragment f3p4, which was selected from a subset of the synthetic HuCAL antibody library to bind the sodium citrate symporter CitS, is described at 1.92 A resolution.	Sodium Citrate	134-148	FA complementation group B	Homo sapiens	30-33
17133509-7	2007	In contrast, a positive impact of these modifications on the activity of released VEGF was observed; in case of the phosphoserine- and sodium citrate-modified cements, the biological efficacy of released VEGF was even higher than that of nonreleased control VEGF.	Sodium Citrate	135-149	vascular endothelial growth factor A	Homo sapiens	82-86
17133509-7	2007	In contrast, a positive impact of these modifications on the activity of released VEGF was observed; in case of the phosphoserine- and sodium citrate-modified cements, the biological efficacy of released VEGF was even higher than that of nonreleased control VEGF.	Sodium Citrate	135-149	vascular endothelial growth factor A	Homo sapiens	204-208
17133509-7	2007	In contrast, a positive impact of these modifications on the activity of released VEGF was observed; in case of the phosphoserine- and sodium citrate-modified cements, the biological efficacy of released VEGF was even higher than that of nonreleased control VEGF.	Sodium Citrate	135-149	vascular endothelial growth factor A	Homo sapiens	204-208
16754985-3	2006	Crystals of recombinant LAT have been grown in 0.1 M trisodium citrate dihydrate solution containing 0.2 M ammonium acetate and 25% PEG 4000 in the pH range 5.4-6.0.	Sodium Citrate	53-80	L-lysine-epsilon aminotransferase	Mycobacterium tuberculosis H37Rv	24-27
16254264-2	2005	Linear regression analysis of cTnI levels in paired serum and sodium-citrate plasma samples from 80 patients provided a y-intercept of -0.0193 and a slope of 1.044.	Sodium Citrate	62-76	troponin I3, cardiac type	Homo sapiens	30-34
16519144-6	2006	Sperm in egg yolk-glycerol-sodium citrate group added I g/L albumin manifested significantly higher succinate dehydrogenase (SDH) activity than that in control group (P < 0.05) and had better ultrastructure than that in control group.	Sodium Citrate	27-41	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	100-123
16519144-6	2006	Sperm in egg yolk-glycerol-sodium citrate group added I g/L albumin manifested significantly higher succinate dehydrogenase (SDH) activity than that in control group (P < 0.05) and had better ultrastructure than that in control group.	Sodium Citrate	27-41	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	125-128
14597991-2	2003	We measured ex vivo (basal) and in vitro (thrombin-induced) platelet activation in sodium citrate, ethylenediaminetetraacetic acid (EDTA), and Citrate Theophylline Dipyridamole Adenosine (CTAD) whole blood specimens.	Sodium Citrate	83-97	coagulation factor II, thrombin	Homo sapiens	42-50
16076719-6	2005	She had been treated with oral sodium citrate, potassium citrate and potassium chloride supplementation because of dRTA since the age of 1 month.	Sodium Citrate	31-45	rta	Drosophila melanogaster	115-119
15247288-4	2004	Here we find that Escherichia coli IscU fails to assemble iron-sulfur clusters when the accessible "free" iron in solution is limited by an iron chelator sodium citrate.	Sodium Citrate	154-168	iron-sulfur cluster assembly enzyme	Homo sapiens	35-39
14597991-7	2003	Addition of thrombin induced a significant change in platelet MPC for sodium citrate (21.9 +/- 1.9 g/dl; p<0.0001) and EDTA (23.2 +/- 0.9 g/dl; p<0.0001) whole blood specimens.	Sodium Citrate	70-84	coagulation factor II, thrombin	Homo sapiens	12-20
14597991-9	2003	In vitro fluorescence flow cytometric platelet activation experiments measuring the percentage of platelets expressing anti-CD62P showed increase in sodium citrate specimens from 9.2 +/- 7.0 to 55.5 +/- 23.1 % (p<0.0001) and in EDTA specimens from 1.9 +/- 1.7 to 64.6 +/- 12.4 % (p<0.0001) after addition of thrombin.	Sodium Citrate	149-163	selectin P	Homo sapiens	124-129
14597991-9	2003	In vitro fluorescence flow cytometric platelet activation experiments measuring the percentage of platelets expressing anti-CD62P showed increase in sodium citrate specimens from 9.2 +/- 7.0 to 55.5 +/- 23.1 % (p<0.0001) and in EDTA specimens from 1.9 +/- 1.7 to 64.6 +/- 12.4 % (p<0.0001) after addition of thrombin.	Sodium Citrate	149-163	coagulation factor II, thrombin	Homo sapiens	314-322
14507009-3	2003	The separation of MFGM from the skim milk proteins present in commercial buttermilk was carried out by the addition of sodium citrate followed by microfiltration through a membrane of 0.1-microm nominal pore size.	Sodium Citrate	119-133	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	18-22
12899628-5	2003	By contrast, apoA-V is soluble in 50 mM sodium citrate (pH 3.0).	Sodium Citrate	40-54	apolipoprotein A5	Homo sapiens	13-19
12876366-3	2003	DJ-1 was crystallized using sodium citrate and HEPES at pH 7.5.	Sodium Citrate	28-42	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	0-4
11679750-4	2001	Crystals of an antigen-binding fragment (Fab) of m-HFE7A were obtained by the hanging-drop vapour-diffusion method using sodium citrate as a precipitant and 2-methyl-2,4-pentanediol as an additive.	Sodium Citrate	121-135	FA complementation group B	Homo sapiens	41-44
12595723-1	2003	A recombinant form of the CTP synthetase from Thermus thermophilus HB8 (tCTPs) was grown as colourless crystals by the hanging-drop vapour-diffusion technique using ammonium sulfate or sodium citrate as a precipitating agent.	Sodium Citrate	185-199	CTP synthase	Thermus thermophilus HB8	26-40
12920818-10	2003	The best effect of Estrogen Receptor needs pH 8.0 sodium citrate solution.	Sodium Citrate	50-64	estrogen receptor 1	Homo sapiens	19-36
12554948-1	2003	Crystals of cytochrome c peroxidase from Pseudomonas stutzeri were obtained using sodium citrate and PEG 8000 as precipitants.	Sodium Citrate	82-96	efflux RND transporter periplasmic adaptor subunit	Pseudomonas stutzeri	12-35
12411726-2	2003	This study examined the efficacy of delayed therapy with sodium citrate, the effect of sodium citrate therapy on kidney cortex levels of transforming growth factor-beta (TGF-beta), and the response to calcium citrate ingestion.	Sodium Citrate	87-101	transforming growth factor, beta 1	Rattus norvegicus	170-178
12411726-6	2003	Sodium citrate treatment, started at age 1 month, lowered TGF-beta levels to normal in 3-month-old rats, but this is probably not the primary mechanism of citrate"s beneficial effect.	Sodium Citrate	0-14	transforming growth factor, beta 1	Rattus norvegicus	58-66
12198308-3	2002	Pyridoxal kinase from sheep brain was crystallized in an orthorhombic form using the hanging-drop vapour-diffusion method with sodium citrate as the precipitant.	Sodium Citrate	127-141	pyridoxal kinase	Ovis aries	0-16
12136152-1	2002	The terminal oxygenase component (CarAa) of carbazole 1,9a-dioxygenase from Pseudomonas resinovorans strain CA10 was crystallized at 293 K using the sitting-drop vapour-diffusion method under the following conditions: 0.1 M sodium citrate pH 5.6 in the presence of 0.5 M ammonium sulfate and 1.0 M lithium sulfate.	Sodium Citrate	224-238	carAa	Pseudomonas resinovorans	34-39
12130502-10	2002	HSFC proliferation was increased in a dose-dependent fashion and c-myc expression was enhanced by ferric citrate compared to sodium citrate control.	Sodium Citrate	125-139	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	65-70
12369414-4	2002	Dissociation of TGase-treated casein micelles by urea or sodium citrate or removal of colloidal calcium phosphate by acidification and dialysis was reduced, presumably due to the formation of cross-links between the caseins.	Sodium Citrate	57-71	transglutaminase 1	Homo sapiens	16-21
11856838-1	2002	Crystals of the Oct-1 POU/SNAP190 peptide/DNA tertiary complex have been obtained by hanging-drop vapor diffusion at 293K in 20% 2-propanol, 20% PEG 4000 and 0.1M sodium citrate pH 5.6.	Sodium Citrate	163-177	POU class 2 homeobox 1	Homo sapiens	16-21
11856838-1	2002	Crystals of the Oct-1 POU/SNAP190 peptide/DNA tertiary complex have been obtained by hanging-drop vapor diffusion at 293K in 20% 2-propanol, 20% PEG 4000 and 0.1M sodium citrate pH 5.6.	Sodium Citrate	163-177	small nuclear RNA activating complex polypeptide 4	Homo sapiens	26-33
10089422-3	1999	Crystals of human RCC1 suitable for X-ray analysis have been obtained using the seeding technique in hanging drops with sodium citrate as a precipitant.	Sodium Citrate	120-134	regulator of chromosome condensation 1	Homo sapiens	18-22
10962087-1	2000	Sodium citrate has previously been shown to convert native alpha(1)-antitrypsin into the inactive latent state and cause alpha(1)-antitrypsin to polymerize via the C-sheet pathway instead of the more common A-sheet pathway.	Sodium Citrate	0-14	serpin family A member 1	Homo sapiens	59-79
10962087-1	2000	Sodium citrate has previously been shown to convert native alpha(1)-antitrypsin into the inactive latent state and cause alpha(1)-antitrypsin to polymerize via the C-sheet pathway instead of the more common A-sheet pathway.	Sodium Citrate	0-14	serpin family A member 1	Homo sapiens	121-141
10962087-2	2000	In order to begin to understand these dramatic effects, we have examined the influence of low concentrations of sodium citrate upon the structure, stability and function of alpha(1)-antitrypsin.	Sodium Citrate	112-126	serpin family A member 1	Homo sapiens	173-193
10666577-3	1999	Apo Delta(1-43)A-I crystallizes from 1.0-1.4 M sodium citrate pH 6.5-7.5 in space group P2(1)2(1)2(1), with unit-cell parameters a = 97.47, b = 113.87, c = 196.19 A (crystal form I).	Sodium Citrate	47-61	aminopeptidase O (putative)	Homo sapiens	0-3
10393303-1	1999	The R2 subdomain of the mouse c-Myb DNA-binding domain and its V103L mutant have been crystallized by the vapour-diffusion method using highly concentrated sodium citrate at pH 6.8 as a precipitant.	Sodium Citrate	156-170	myeloblastosis oncogene	Mus musculus	30-35
14646495-7	1998	The inhibition profiles by aurintricarboxylic acid, sodium citrate and divalent metal ions such as Co2+, Ni2+, Cu2+ and Zn2+ were similar to those of mammalian DNase gamma.	Sodium Citrate	52-66	deoxyribonuclease 1 like 3	Homo sapiens	160-171
9786066-10	1998	When sodium citrate dissolved in dextrose was added to medium, there was considerable damage to both PPH and the C3A cell line.	Sodium Citrate	5-19	complement C3	Homo sapiens	113-116
9016863-7	1997	In contrast, samples anticoagulated with sodium citrate after DDAVP did not show a normalized vWf multimer pattern and were characterized by a persistently decreased vWf:CBA.	Sodium Citrate	41-55	von Willebrand factor	Homo sapiens	166-169
8760462-1	1996	The form-B monoclinic insulin crystal was obtained from the sodium citrate buffer with 1% zinc chloride, keeping phenolic content between 0.76% and 1.25%.	Sodium Citrate	60-74	insulin	Bos taurus	22-29
8870177-2	1996	Platelet phospholipid-dependent thrombin generation (Platelet-TG) could be measured using platelets isolated from blood collected into either sodium citrate or EDTA as anticoagulant.	Sodium Citrate	142-156	coagulation factor II, thrombin	Homo sapiens	32-40
8110432-3	1993	We therefore examined the effect of dietary intake of sodium chloride or sodium citrate on the activity of the renin-angiotensin-aldosterone and the sympathetic nervous system during rest and following stimulation by active orthostasis in normotensive salt-sensitive (n = 7) and salt-resistant (n = 8) subjects.	Sodium Citrate	73-87	renin	Homo sapiens	111-116
1488047-1	1992	Single-strand-preferring ribonucleases of the pancreatic type, structurally and/or catalytically similar to bovine RNase A but endowed with a higher protein basicity, are able to degrade double-stranded RNA (dsRNA) or DNA:RNA hybrids under standard assay conditions (0.15 M NaCl, 0.015 M sodium citrate, pH 7), where RNase A is inactive.	Sodium Citrate	288-302	ribonuclease pancreatic	Bos taurus	115-122
1488047-1	1992	Single-strand-preferring ribonucleases of the pancreatic type, structurally and/or catalytically similar to bovine RNase A but endowed with a higher protein basicity, are able to degrade double-stranded RNA (dsRNA) or DNA:RNA hybrids under standard assay conditions (0.15 M NaCl, 0.015 M sodium citrate, pH 7), where RNase A is inactive.	Sodium Citrate	288-302	ribonuclease pancreatic	Bos taurus	317-324
22061433-4	1991	The best conditions for a reliable detection of cathepsin D in dry-cured ham were found to be the incubation of the enzyme extract for 1 h at 45 C in a reaction mixture containing 0 60% (w/v) of haemoglobin in 0 2 m sodium citrate buffer, pH = 3 7.	Sodium Citrate	216-230	cathepsin D	Homo sapiens	48-59
1650222-7	1991	Calcium phosphorylcholine (10 micrograms/ml) or sodium citrate (10 micrograms/ml) completely dissociated bound CRP.	Sodium Citrate	48-62	C-reactive protein	Homo sapiens	111-114
34119736-1	2021	The oxidative degradation of atrazine (ATR) using bimetallic Bi/Fe0 nanoparticles cooperated with citric acid (CA) and sodium citrate (NaCA) without extra addition of H2O2 or another oxidant was conducted.	Sodium Citrate	119-133	nascent polypeptide associated complex subunit alpha	Homo sapiens	135-139
2341289-3	1990	Their behavior in the presence of sodium citrate supports the concept of lactoferrin-binding by the cells as responsible for the uptake.	Sodium Citrate	34-48	lactotransferrin	Mus musculus	73-84
2675969-2	1989	In order to better characterize this protein, CP4 was isolated from rat bronchoalveolar lavage and EDTA extracts of lung surfactant by adsorption to barium sulfate and elution with sodium citrate followed by reverse-phase HPLC.	Sodium Citrate	181-195	surfactant protein D	Rattus norvegicus	46-49
34687512-2	2021	Platelet-rich plasma (PRP) is an autogenous source for growth factors based on platelet concentration, which can be obtained by centrifuging whole blood collected in sodium citrate anticoagulant.	Sodium Citrate	166-180	complement component 4 binding protein alpha	Homo sapiens	22-25
2922698-4	1989	Whole blood anticoagulated by heparin, EDTA or sodium citrate, contained dephosphorylating activity against 32P-labeled fibrinogen, although there were significant differences in activity among the three anticoagulants.	Sodium Citrate	47-61	fibrinogen beta chain	Homo sapiens	120-130
2709264-7	1989	Differential extraction of PTP and PSP by 0.1N HCl and 10% sodium citrate produced Mr 14,000 products that reacted equally with each monoclonal antibody (MAB).	Sodium Citrate	59-73	regenerating family member 1 alpha	Homo sapiens	27-30
2674057-1	1989	The results from gel chromatography and electrophoresis showed that 67Ga is exclusively bound with transferrin both in vitro and in vivo, but high concentrations of sodium citrate strongly inhibited the binding of 67Ga to transferrin.	Sodium Citrate	165-179	transferrin	Homo sapiens	222-233
3832701-1	1985	Prothrombin isolated from duck sodium citrate plasma was activated in a system containing duck factor Xa and calcium ions.	Sodium Citrate	31-45	coagulation factor II, thrombin	Homo sapiens	0-11
3343546-0	1988	Evidence of increased association of fibrinogen with platelets caused by sodium citrate.	Sodium Citrate	73-87	fibrinogen beta chain	Homo sapiens	37-47
3610670-6	1987	Moreover, AlP activity was diminished in tissue sections from bones fixed in 70% ethanol or 10% formalin and subsequently demineralized in 10% EDTA (pH 7) for 2 days, and the activity was completely abolished in tissue sections from bones subsequently demineralized in 5% formic acid: 20% sodium citrate (1:1, pH 4.2) for 2 days.	Sodium Citrate	289-303	ATHS	Homo sapiens	10-13
3672052-1	1987	Low-dose nalidixic acid (0.66 g) in combination with 4 g of sodium citrate (NAC) was evaluated in acute lower UTI.	Sodium Citrate	60-74	synuclein alpha	Homo sapiens	76-79
3541281-1	1986	The responsiveness of washed human platelets to thrombin was well preserved up to 72 and 96 hours, when they were stored at 4 degrees C with prostaglandin I2 (PGI2) and its stable analogue OP-41483, respectively, while the washed platelets stored with sodium citrate completely lost their responsiveness to thrombin at 48 hours.	Sodium Citrate	252-266	coagulation factor II, thrombin	Homo sapiens	48-56
3012375-2	1986	BTG and PF4 release from blood anticoagulated with sodium citrate was inhibited by AD6 during a 3 h incubation.	Sodium Citrate	51-65	platelet factor 4	Homo sapiens	8-11
3832701-1	1985	Prothrombin isolated from duck sodium citrate plasma was activated in a system containing duck factor Xa and calcium ions.	Sodium Citrate	31-45	coagulation factor X	Homo sapiens	95-104
7296000-1	1981	Two fractions of human prothrombin can be isolated from single donor plasma by the technique of heparin-agarose chromatography in (sodium) citrate buffer, pH 7.5, as previously reported for pooled plasma.	Sodium Citrate	130-146	coagulation factor II, thrombin	Homo sapiens	23-34
6516292-3	1984	Pasteurization of the AT III concentrate in the presence of 0.5 M sodium citrate to minimize the risk of hepatitis decreases the recovery by about 20% and induces changes in the patterns obtained by polyacrylamide gel electrophoresis and by crossed immunoelectrophoresis in heparinized agarose gel.	Sodium Citrate	66-80	serpin family C member 1	Homo sapiens	22-28
6433926-3	1983	Subsequent treatment of the CRP-lecithin complex with chloroform and sodium citrate buffer enabled extraction of the CRP in the buffer layer.	Sodium Citrate	69-83	C-reactive protein	Homo sapiens	28-31
6433926-3	1983	Subsequent treatment of the CRP-lecithin complex with chloroform and sodium citrate buffer enabled extraction of the CRP in the buffer layer.	Sodium Citrate	69-83	C-reactive protein	Homo sapiens	117-120
7028925-0	1981	Plasma parathyroid hormone and insulin concentrations in cows administered potassium chloride and sodium citrate.	Sodium Citrate	98-112	insulin	Bos taurus	31-38
7292440-0	1981	Activation of factor X and thrombin zymogens in 25% sodium citrate solution.	Sodium Citrate	52-66	coagulation factor II, thrombin	Homo sapiens	27-35
7276209-1	1981	Samples which are taken for the Quick one-stage prothrombin time estimation for the control of patients receiving oral anticoagulant treatment are by convention taken into liquid sodium citrate anticoagulant.	Sodium Citrate	179-193	coagulation factor II, thrombin	Homo sapiens	48-59
7276209-3	1981	Tests were performed with both liquid and dried sodium citrate as an anticoagulant for prothrombin time and Thrombotest.	Sodium Citrate	48-62	coagulation factor II, thrombin	Homo sapiens	87-98
166481-5	1975	Sodium citrate and aminotriazole and feeding decrease also the activity of hepatic catalase in rats fed ASA.	Sodium Citrate	0-14	catalase	Rattus norvegicus	83-91
7413850-2	1980	However, preincubation of platelet rich plasma (PRP) prepared in sodium citrate with AA (1 mM) enhanced the aggregation induced by collagen suspension or adenosine diphosphate (ADP), and this enhancement was abolished by the preincubation of PRP with indomethacin.	Sodium Citrate	65-79	proline rich protein 2-like 1	Rattus norvegicus	48-51
78721-10	1978	Sodium citrate was found to inhibit platelet release induced by thrombin.	Sodium Citrate	0-14	coagulation factor II, thrombin	Homo sapiens	64-72
1239312-4	1975	The activation of maleyl-prothrombin to maleyl-thrombin took place in 25% sodium citrate only in the presence of thrombin and the Xa factor.	Sodium Citrate	74-88	coagulation factor II, thrombin	Bos taurus	25-36
1239312-4	1975	The activation of maleyl-prothrombin to maleyl-thrombin took place in 25% sodium citrate only in the presence of thrombin and the Xa factor.	Sodium Citrate	74-88	coagulation factor II, thrombin	Bos taurus	28-36
1239312-4	1975	The activation of maleyl-prothrombin to maleyl-thrombin took place in 25% sodium citrate only in the presence of thrombin and the Xa factor.	Sodium Citrate	74-88	coagulation factor II, thrombin	Bos taurus	47-55
5708142-0	1968	History of prothrombin activation in sodium citrate solution.	Sodium Citrate	37-51	coagulation factor II, thrombin	Homo sapiens	11-22
16955973-3	1965	Under certain circumstances, the ratio of C to E for human thrombin is not constant, particularly upon gel-filtration at low ionic strength and during prolonged contact with 25% sodium citrate.	Sodium Citrate	178-192	coagulation factor II, thrombin	Homo sapiens	59-67
13465778-0	1957	Inhibition of prothrombin activation in sodium citrate solutions.	Sodium Citrate	40-54	coagulation factor II, thrombin	Homo sapiens	14-25
14493215-0	1962	beta-Hydroxybutyrate and sodium citrate as stimuli of the in vitro secretion of insulin.	Sodium Citrate	25-39	insulin	Homo sapiens	80-87
13081140-0	1953	Carbohydrate and nitrogen distribution during the activation of purified prothrombin in sodium citrate solution.	Sodium Citrate	88-102	coagulation factor II, thrombin	Homo sapiens	73-84
15414198-0	1950	Some properties of purified prothrombin and its activation with sodium citrate.	Sodium Citrate	64-78	coagulation factor II, thrombin	Homo sapiens	28-39
12997268-0	1952	The effect of sodium citrate on the fibrinolytic activity of plasmin and trypsin.	Sodium Citrate	14-28	plasminogen	Homo sapiens	61-68
18891145-3	1948	(b) Sodium citrate begins to depress prothrombin activity at a concentration at which ionized calcium is still present.	Sodium Citrate	4-18	coagulation factor II, thrombin	Homo sapiens	37-48
33570605-2	2021	MATERIALS AND METHODS: NAg was synthesized using a sodium citrate reduction method.	Sodium Citrate	51-65	NBAS subunit of NRZ tethering complex	Homo sapiens	23-26
33937192-4	2021	This efficient strategy involved the reduction of Au(III) by Zn(0) powder in aqueous medium, where sodium citrate (NaCt) was the stabilizing agent.	Sodium Citrate	99-113	solute carrier family 13 member 5	Homo sapiens	115-119
32529225-6	2020	RESULTS: We applied this method to determine the activities of both coagulation factor IIa and plasmin in their physiologically relevant basal state and fully activated state in sodium citrate-anticoagulated plasma respectively.	Sodium Citrate	178-192	plasminogen	Homo sapiens	95-102
32627718-10	2020	Measured concentrations of CysC (p = 0.018) and NGAL (p = 0.015) were significantly lower in sodium citrate plasma compared to serum.	Sodium Citrate	93-107	lipocalin 2	Canis lupus familiaris	48-52
33455307-4	2020	During the cross-linking of gelatin and mTG, the sacrificial templates started to dissolve from the scaffold-template interface due to the presence of the sodium citrate in the gelatin.	Sodium Citrate	155-169	protease, serine 3	Mus musculus	40-43
32549773-0	2020	Thrombin generation in different commercial sodium citrate blood tubes.	Sodium Citrate	44-58	coagulation factor II, thrombin	Homo sapiens	0-8
31584012-1	2019	Bovine beta-lactoglobulin was crystallized from 3 M NaCl buffered at pH 3.8 with sodium citrate as thick hexagonal prisms of greater than 1 mm in edge length.	Sodium Citrate	81-95	beta-lactoglobulin	Bos taurus	7-25
31013820-3	2019	This study was undertaken with aim to test the hypothesis that ingestion of an alkalizing substance (sodium citrate; CIT) after dehydrating exercise would decrease blood levels of stress hormones during subsequent 40 km cycling time-trial (TT) in the heat.	Sodium Citrate	101-115	citron rho-interacting serine/threonine kinase	Homo sapiens	117-120
30511220-2	2019	In a running of EK-PRB, reductant (ascorbic acid, sodium citrate) and chelating agent (EDTA-2Na) were used to pretreat contaminated soil together with CaAl-LDH as reactive materials for PRB.	Sodium Citrate	50-64	RB transcriptional corepressor 1	Homo sapiens	186-189
29419916-5	2018	A sodium citrate plasma sample should be collected for ADAMTS13 testing prior to any plasma therapy.	Sodium Citrate	2-16	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	55-63
30053689-2	2018	Inspired by the role of citrate in the growth of apatite crystals during natural bio-mineralization, uniform and nearly monodisperse Eu3+-doped CaF2 nanoparticles with excellent colloidal stability and high fluorescence in aqueous media have been successfully synthesized in the presence of sodium citrate using a hydrothermal method.	Sodium Citrate	291-305	CCR4-NOT transcription complex subunit 8	Homo sapiens	144-148
30053689-3	2018	X-ray diffraction and transmission electron microscopy show that CaF2 nanoparticles grown in the presence of sodium citrate are cubes of relatively uniform size (15 nm), and that the Eu3+ doping level has little effect on size and morphology.	Sodium Citrate	109-123	CCR4-NOT transcription complex subunit 8	Homo sapiens	65-69
30053689-4	2018	Zeta potentials and dynamic light scattering demonstrate that in the synthesis with sodium citrate, the colloidal stability of CaF2 nanoparticles is greatly improved upon the increase of Eu3+ doping level.	Sodium Citrate	84-98	CCR4-NOT transcription complex subunit 8	Homo sapiens	127-131
30053689-7	2018	Fourier transform infrared spectra and thermogravimetric analyses demonstrate the adsorption of substantial quantities of sodium citrate on the surfaces of the CaF2 nanoparticles.	Sodium Citrate	122-136	CCR4-NOT transcription complex subunit 8	Homo sapiens	160-164
30241394-0	2018	Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells.	Sodium Citrate	0-14	Eph receptor B1	Rattus norvegicus	102-105
30241394-0	2018	Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells.	Sodium Citrate	0-14	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	106-111
30241394-4	2018	Sodium citrate (SC) increased the mRNA levels of TRPM6 and CNNM2 in renal tubular epithelial NRK-52E cells.	Sodium Citrate	0-14	transient receptor potential cation channel, subfamily M, member 6	Rattus norvegicus	49-54
30241394-4	2018	Sodium citrate (SC) increased the mRNA levels of TRPM6 and CNNM2 in renal tubular epithelial NRK-52E cells.	Sodium Citrate	0-14	cyclin and CBS domain divalent metal cation transport mediator 2	Rattus norvegicus	59-64
29582550-5	2018	A sodium citrate plasma sample should be collected for ADAMTS13 testing prior to any plasma therapy.	Sodium Citrate	2-16	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	55-63
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	16-30	interleukin 1 beta	Homo sapiens	68-85
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	16-30	interleukin 1 beta	Homo sapiens	87-95
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	16-30	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	16-30	tumor necrosis factor	Homo sapiens	107-128
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	16-30	interleukin 6	Homo sapiens	197-201
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	169-183	interleukin 1 beta	Homo sapiens	68-85
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	169-183	interleukin 1 beta	Homo sapiens	87-95
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	169-183	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	169-183	tumor necrosis factor	Homo sapiens	107-128
29616124-4	2018	Incubation with sodium citrate for 24 h revealed that the levels of interleukin-1beta (IL-1beta), IL-8 and tumor necrosis factor increased with an increasing of dose of sodium citrate, whereas the IL-6 levels exhibited only a slight alteration.	Sodium Citrate	169-183	interleukin 6	Homo sapiens	197-201
29616124-5	2018	In addition, increases in caspase-3 and -9 activities were associated with increased duration of treatment and dosage of sodium citrate.	Sodium Citrate	121-135	caspase 3	Homo sapiens	26-42
28687385-7	2017	For comparison, the sorption capacity of chitosan cross-linked ionically with sodium citrate was: 0.43, 0.39 and 0.39mmol/g for P-PO4, N-NO2 and N-NO3, respectively (total of 1.21mmol/g).	Sodium Citrate	78-92	membrane frizzled-related protein	Homo sapiens	135-140
28687385-7	2017	For comparison, the sorption capacity of chitosan cross-linked ionically with sodium citrate was: 0.43, 0.39 and 0.39mmol/g for P-PO4, N-NO2 and N-NO3, respectively (total of 1.21mmol/g).	Sodium Citrate	78-92	NNO3	Homo sapiens	145-150
28415912-6	2017	Heat-induced retrieval gave positive results for osterix immunohistochemical staining in sodium citrate/EDTA/Tween 20 with high heat (120C) and pressure (~30 psi) for 10 min, but the heat and pressure levels resulted in tissue damage and section delamination from slides that limited protocol effectiveness.	Sodium Citrate	89-103	Sp7 transcription factor	Homo sapiens	49-56
24734555-1	2014	A series of rare-earth ions (Er3+ and Yb3+) Co-doped CaF2 upconversion luminescent nanomaterials have been successfully prepared via a facile hydrothermal method using pluronic p123 (p123), pluronic F127 (F127) and sodium citrate as surfactants at 180 degrees C with different reaction time.	Sodium Citrate	215-229	CCR4-NOT transcription complex subunit 8	Homo sapiens	53-57
27422133-9	2017	Within plasma, myeloperoxidase concentrations were slightly higher in ethylenediaminetetraacetic acid (307.7 +- 52.1) and lower in lithium heparin (290.3 +- 49.2) and sodium citrate (221.4 +- 40.3) but not statistically significant.	Sodium Citrate	167-181	myeloperoxidase	Homo sapiens	15-30
27091175-6	2016	Cell proliferation and specific marker protein expression results also revealed that with the help of sodium citrate degradation, the printed HCECs showed a higher proliferation rate and greater cytokeratin 3(CK3) expression, indicating that this newly developed method may help to improve the alginate bioink system for the application of 3D bioprinting in tissue engineering.	Sodium Citrate	102-116	keratin 3	Homo sapiens	195-208
27091175-6	2016	Cell proliferation and specific marker protein expression results also revealed that with the help of sodium citrate degradation, the printed HCECs showed a higher proliferation rate and greater cytokeratin 3(CK3) expression, indicating that this newly developed method may help to improve the alginate bioink system for the application of 3D bioprinting in tissue engineering.	Sodium Citrate	102-116	keratin 3	Homo sapiens	209-212
26303579-7	2015	Western blot analysis showed that sodium citrate treatment decreased the protein levels of transforming growth factor-beta 1 and collagen type IV, which were increased in model rats.	Sodium Citrate	34-48	transforming growth factor, beta 1	Rattus norvegicus	91-124
25280686-4	2014	It could be found that the postponement of the maximum accumulated release of bovine serum albumin was found due to the presence of sodium citrate and different types of polyvinyl alcohol.	Sodium Citrate	132-146	albumin	Homo sapiens	85-98
24814970-1	2014	INTRODUCTION: Conventional Vacutainer  Sodium Citrate blood collection tubes contain a relatively high concentration of contaminating magnesium ions, which may result in shortening of the prothrombin time (PT) and the International Normalized Ratio (INR).	Sodium Citrate	39-53	coagulation factor II, thrombin	Homo sapiens	188-199
24498239-6	2014	Cells subcultured for 25 passages using this novel sodium citrate passaging solution exhibit characteristic hPSC morphology, high levels (>80%) of pluripotency markers OCT4, SSEA-4, TRA-1-60 andTRA-1-81, a normal G-banded karyotype and the ability to differentiate into cells representing all three germ layers, both in vivo and in vitro.	Sodium Citrate	51-65	POU class 5 homeobox 1	Homo sapiens	171-175
24498239-6	2014	Cells subcultured for 25 passages using this novel sodium citrate passaging solution exhibit characteristic hPSC morphology, high levels (>80%) of pluripotency markers OCT4, SSEA-4, TRA-1-60 andTRA-1-81, a normal G-banded karyotype and the ability to differentiate into cells representing all three germ layers, both in vivo and in vitro.	Sodium Citrate	51-65	phospholipid scramblase 4	Homo sapiens	185-190
22884434-4	2012	It was observed that when 0.1 M sodium citrate (NaC) and 0.1 M sodium tartrate (NaT) were used separately, the gelation temperature of MC was reduced up to 44 C and 47 C respectively but when mixture of NaC and NaT (0.1 (M) NaC and 0.1 (M) (NaT)) were used the gelation temperature was further reduced to 36 C. It was clear from ESEM images that when NaC and NaT were used separately the formation of network was not distinguishable.	Sodium Citrate	32-46	synuclein alpha	Homo sapiens	48-51
24898333-1	2014	Millions of clotting tests each year require recalcification of blood treated with sodium citrate, a calcium chelator that prevents prothrombinase assembly.	Sodium Citrate	83-97	coagulation factor X	Homo sapiens	132-146
24185055-2	2013	nAg was synthesized via Tollens" method using sodium citrate as stabilizer; its morphology, UV-Vis spectrum, and particle size were characterized.	Sodium Citrate	46-60	NBAS subunit of NRZ tethering complex	Homo sapiens	0-3
22884434-4	2012	It was observed that when 0.1 M sodium citrate (NaC) and 0.1 M sodium tartrate (NaT) were used separately, the gelation temperature of MC was reduced up to 44 C and 47 C respectively but when mixture of NaC and NaT (0.1 (M) NaC and 0.1 (M) (NaT)) were used the gelation temperature was further reduced to 36 C. It was clear from ESEM images that when NaC and NaT were used separately the formation of network was not distinguishable.	Sodium Citrate	32-46	synuclein alpha	Homo sapiens	203-206
22884434-4	2012	It was observed that when 0.1 M sodium citrate (NaC) and 0.1 M sodium tartrate (NaT) were used separately, the gelation temperature of MC was reduced up to 44 C and 47 C respectively but when mixture of NaC and NaT (0.1 (M) NaC and 0.1 (M) (NaT)) were used the gelation temperature was further reduced to 36 C. It was clear from ESEM images that when NaC and NaT were used separately the formation of network was not distinguishable.	Sodium Citrate	32-46	bromodomain containing 2	Homo sapiens	211-214
22884434-4	2012	It was observed that when 0.1 M sodium citrate (NaC) and 0.1 M sodium tartrate (NaT) were used separately, the gelation temperature of MC was reduced up to 44 C and 47 C respectively but when mixture of NaC and NaT (0.1 (M) NaC and 0.1 (M) (NaT)) were used the gelation temperature was further reduced to 36 C. It was clear from ESEM images that when NaC and NaT were used separately the formation of network was not distinguishable.	Sodium Citrate	32-46	synuclein alpha	Homo sapiens	203-206
22884434-4	2012	It was observed that when 0.1 M sodium citrate (NaC) and 0.1 M sodium tartrate (NaT) were used separately, the gelation temperature of MC was reduced up to 44 C and 47 C respectively but when mixture of NaC and NaT (0.1 (M) NaC and 0.1 (M) (NaT)) were used the gelation temperature was further reduced to 36 C. It was clear from ESEM images that when NaC and NaT were used separately the formation of network was not distinguishable.	Sodium Citrate	32-46	bromodomain containing 2	Homo sapiens	211-214
22884434-4	2012	It was observed that when 0.1 M sodium citrate (NaC) and 0.1 M sodium tartrate (NaT) were used separately, the gelation temperature of MC was reduced up to 44 C and 47 C respectively but when mixture of NaC and NaT (0.1 (M) NaC and 0.1 (M) (NaT)) were used the gelation temperature was further reduced to 36 C. It was clear from ESEM images that when NaC and NaT were used separately the formation of network was not distinguishable.	Sodium Citrate	32-46	synuclein alpha	Homo sapiens	203-206
22884434-4	2012	It was observed that when 0.1 M sodium citrate (NaC) and 0.1 M sodium tartrate (NaT) were used separately, the gelation temperature of MC was reduced up to 44 C and 47 C respectively but when mixture of NaC and NaT (0.1 (M) NaC and 0.1 (M) (NaT)) were used the gelation temperature was further reduced to 36 C. It was clear from ESEM images that when NaC and NaT were used separately the formation of network was not distinguishable.	Sodium Citrate	32-46	bromodomain containing 2	Homo sapiens	211-214
22862794-7	2012	RESULTS: We judged that samples of whole blood with 2K-EDTA were suitable for CD62P expression assay as functional assessments of platelet activity, because platelets treated with anticoagulants such as sodium citrate and heparin were extremely damaged after stimulation, and it was difficult to measure the CD62P expression by flow cytometry.	Sodium Citrate	203-217	selectin P	Homo sapiens	308-313