PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19429469-9	2009	ND determines an increase in the TBP content in DECA group (35+/-3%; p<0.01) compared with control animals (18+/-1%).	decabromobiphenyl ether	48-52	TATA box binding protein	Rattus norvegicus	33-36
19874087-1	2009	We evaluated the available pharmacokinetic data and human and animal toxicity data for 2,2",3,3",4,4",5,5",6,6"-decabromodiphenyl ether (BDE-209) (CASRN 1163-19-5) with the objective of deriving a reference dose (RfD) based on the best available science.	decabromobiphenyl ether	87-135	homeobox D13	Homo sapiens	137-140
20183492-4	2009	Mass ratios of BDE206/BDE209 are higher in both indoor and outdoor samples than in commercial deca products; and mass ratio BDE47/BDEs(85+99+100) was much higher in outdoor than in indoor samples.	decabromobiphenyl ether	94-98	homeobox D13	Homo sapiens	15-18
19731671-1	2009	Photodegradation kinetics of several polybrominated diphenyl ethers (PBDEs), particularly decabromodiphenyl ether (BDE 209), have been reported in various matrixes, demonstrating that it photodegrades primarily via debromination.	decabromobiphenyl ether	90-113	homeobox D13	Homo sapiens	70-73
19731671-7	2009	The octabrominated congener, BDE 202, and the ratio of BDE197 to BDE 201,were identified as congeners that may serve as environmental markers of photolytic debromination of decaBDE.	decabromobiphenyl ether	173-180	homeobox D13	Homo sapiens	29-32
19731671-7	2009	The octabrominated congener, BDE 202, and the ratio of BDE197 to BDE 201,were identified as congeners that may serve as environmental markers of photolytic debromination of decaBDE.	decabromobiphenyl ether	173-180	homeobox D13	Homo sapiens	55-58
20000822-0	2010	Behavior of decabromodiphenyl ether (BDE-209) in the soil-plant system: uptake, translocation, and metabolism in plants and dissipation in soil.	decabromobiphenyl ether	12-35	homeobox D13	Homo sapiens	37-40
20000822-1	2010	Deca-bromodiphenyl ether (BDE-209) is the major component of the commercial deca-BDE flame retardant.	decabromobiphenyl ether	0-24	homeobox D13	Homo sapiens	26-29
20000822-1	2010	Deca-bromodiphenyl ether (BDE-209) is the major component of the commercial deca-BDE flame retardant.	decabromobiphenyl ether	0-24	homeobox D13	Homo sapiens	81-84
19660780-1	2009	Photolysis of deca-bromodiphenyl ether (BDE-209) was investigated in tetrahydrofuran, dichloromethane, isopropanol, acetone, ethanol, methanol, acetonitrile and dimethylsulfoxide.	decabromobiphenyl ether	14-38	homeobox D13	Homo sapiens	40-43
19360447-16	2009	RECOMMENDATIONS AND PERSPECTIVES: BDE-209, the main constituent of DecaBDE, is primarily forming debrominated diphenyl ethers with higher persistence which are more bioaccumulative than the starting material when subjected to UV light.	decabromobiphenyl ether	67-74	homeobox D13	Homo sapiens	34-37
17961649-0	2008	Decabromodiphenyl ether (deca-BDE) commercial mixture components, and other PBDEs, in airborne particles at a UK site.	decabromobiphenyl ether	0-23	homeobox D13	Homo sapiens	30-33
19534115-0	2009	Identifying transfer mechanisms and sources of decabromodiphenyl ether (BDE 209) in indoor environments using environmental forensic microscopy.	decabromobiphenyl ether	47-70	homeobox D13	Homo sapiens	72-75
19452920-2	2009	A deca-bromodiphenyl ether mixture (deca-BDE) is the dominating commercial PBDE product today.	decabromobiphenyl ether	2-26	homeobox D13	Homo sapiens	41-44
18266481-6	2008	The deca-congener, BDE 209, constituted 85 and 9% of SigmaBDEs in the particle and apparent dissolved phases, respectively.	decabromobiphenyl ether	4-8	homeobox D13	Homo sapiens	19-22
18753049-0	2008	[Effect of maternal BDE-209 exposure on the expression of GAP-43 and BDNF in the hippocampus of the offspring rats].	decabromobiphenyl ether	20-27	growth associated protein 43	Rattus norvegicus	58-64
18753049-5	2008	RESULTS: The GAP-43 in the BDE-209-treated groups were lower than that of the control group, and decreased with the increase of the dose of BDE-209 exposure.	decabromobiphenyl ether	27-34	growth associated protein 43	Rattus norvegicus	13-19
18753049-5	2008	RESULTS: The GAP-43 in the BDE-209-treated groups were lower than that of the control group, and decreased with the increase of the dose of BDE-209 exposure.	decabromobiphenyl ether	140-147	growth associated protein 43	Rattus norvegicus	13-19
17961649-1	2008	The occurrence of the major components of the decabromodiphenyl ether (deca-BDE) flame retardant and other PBDEs was investigated in daily air particulate samples from 17th April to 20th May 2004 at a semi-rural site in north-west England.	decabromobiphenyl ether	46-69	homeobox D13	Homo sapiens	76-79
18061678-9	2008	The protein analysis showed that CaMKII increased significantly in hippocampus, but not in cortex, in animals 7 days after exposure to PBDE 209.	decabromobiphenyl ether	135-143	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	33-39
18348638-1	2008	Photolytic degradation of decabromodiphenyl ether (BDE 209) has been observed in several matrices such as solvent/ water mixtures, sediments, and soil; however, no studies have investigated the degradation potential of BDE 209 in house dust.	decabromobiphenyl ether	26-49	homeobox D13	Homo sapiens	51-54
17707457-0	2007	Effect of Tween 80 and beta-cyclodextrin on degradation of decabromodiphenyl ether (BDE-209) by White rot fungi.	decabromobiphenyl ether	59-82	homeobox D13	Homo sapiens	84-87
17707457-1	2007	The environmental safety of decabromodiphenyl ether (BDE-209), a widely used flame retardant, has been the topic of controversial discussions during the past several years.	decabromobiphenyl ether	28-51	homeobox D13	Homo sapiens	53-56
17868175-1	2007	This paper describes the development of a new method using single-drop microextraction (SDME) and RP-HPLC for the determination of decabromodiphenyl ether (BDE-209) in water samples.	decabromobiphenyl ether	131-154	homeobox D13	Homo sapiens	156-159
18044526-3	2007	Congeners of octabromodiphenyl ethers (octaBDEs) originate from used industrial OctaBDE mixtures and from transformation products of the high-volume industrial BFR mixture "DecaBDE", which most exclusively consists of perbrominated diphenyl ether (BDE-209).	decabromobiphenyl ether	173-180	homeobox D13	Homo sapiens	43-46
21959539-0	2007	Fractionation and Determination of Ah Receptor (AhR) Agonists in Organic Waste After Anaerobic Biodegradation and in Batch Experiments with PCB and decaBDE (8 pp).	decabromobiphenyl ether	148-155	aryl hydrocarbon receptor	Homo sapiens	35-46
21959539-0	2007	Fractionation and Determination of Ah Receptor (AhR) Agonists in Organic Waste After Anaerobic Biodegradation and in Batch Experiments with PCB and decaBDE (8 pp).	decabromobiphenyl ether	148-155	aryl hydrocarbon receptor	Homo sapiens	48-51
16758706-0	2006	Ah receptor agonists in UV-exposed toluene solutions of decabromodiphenyl ether (decaBDE) and in soils contaminated with polybrominated diphenyl ethers (PBDEs).	decabromobiphenyl ether	56-79	aryl hydrocarbon receptor 1 alpha	Gallus gallus	0-11
16545423-1	2006	Decabromodiphenyl ether (BDE-209) is a major component of a commercial flame retardant formulation; however, there is limited information on the fate of BDE-209 in the environment, including metal oxide mediated degradation.	decabromobiphenyl ether	0-23	homeobox D13	Homo sapiens	25-28
16913114-1	2006	Understanding of the long-range atmospheric transport (LRT) behavior of decabromodiphenyl ether (BDE-209) is still limited.	decabromobiphenyl ether	72-95	homeobox D13	Homo sapiens	97-100
16758706-0	2006	Ah receptor agonists in UV-exposed toluene solutions of decabromodiphenyl ether (decaBDE) and in soils contaminated with polybrominated diphenyl ethers (PBDEs).	decabromobiphenyl ether	81-88	aryl hydrocarbon receptor 1 alpha	Gallus gallus	0-11
16758706-6	2006	In this study, mechanism-specific dioxin bioassays were used to study photolytic formation of AhR agonists in toluene solutions of decaBDE.	decabromobiphenyl ether	131-138	aryl hydrocarbon receptor 1 alpha	Gallus gallus	94-97
16758706-13	2006	AhR agonists in decaBDE solutions were analysed with two different bioassays, the chick embryo liver-cell assay for dioxins (Celcad) and the dioxin responsive, chemically activated luciferase expression assay (DR-Calux).	decabromobiphenyl ether	16-23	aryl hydrocarbon receptor 1 alpha	Gallus gallus	0-3
16433354-1	2006	The photodebromination of decabromodiphenyl ether (BDE-209) adsorbed onto six different solid matrixes was investigated in sunlight and by irradiation with 350 +/- 50 nm lamps (four lamps at 24 W each).	decabromobiphenyl ether	26-49	homeobox D13	Homo sapiens	51-54
16297962-3	2006	A low concentration of nonabrominated diphenyl ethers (nonaBDEs) is present in commercial DecaBDE and they are also abiotic and biotic debromination products of decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	90-97	homeobox D13	Homo sapiens	59-62
16297962-3	2006	A low concentration of nonabrominated diphenyl ethers (nonaBDEs) is present in commercial DecaBDE and they are also abiotic and biotic debromination products of decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	161-184	homeobox D13	Homo sapiens	59-62
16451851-6	2006	The calculated apparent half-life for decabromodiphenyl ether (BDE-209) was 15 days (95% confidence interval, 11-18 days).	decabromobiphenyl ether	38-61	homeobox D13	Homo sapiens	63-66
16195551-1	2005	Human peripheral-type cannabinoid receptor (CB2) was expressed in Escherichia coli as a fusion with the maltose-binding protein, thioredoxin, and a deca-histidine tag.	decabromobiphenyl ether	148-152	cannabinoid receptor 2	Homo sapiens	44-47
15773480-1	2005	The environmental safety of decabromodiphenyl ether (BDE-209), a widely used flame retardant, has been the topic of controversial discussions during the past several years.	decabromobiphenyl ether	28-51	homeobox D13	Homo sapiens	53-56
15871227-16	2005	The results confirm a significant uptake of BDE-209 in the workers exposed to DecaBDE and indicate a potential for in vivo formation of lower BDEs in these persons.	decabromobiphenyl ether	78-85	homeobox D13	Homo sapiens	44-47
15871227-3	2005	DecaBDE is the major technical polybrominated diphenyl ether (PBDE) in use today and consists mainly of decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	104-127	homeobox D13	Homo sapiens	4-7
16164036-7	2005	The PKC inhibitor Dequalinium chloride (DECA) remarkably reduced the production of IL-6, NF-kappaB and the activity of PKC induced by the piliated S. typhi.	decabromobiphenyl ether	40-44	proline rich transmembrane protein 2	Homo sapiens	4-7
16164036-7	2005	The PKC inhibitor Dequalinium chloride (DECA) remarkably reduced the production of IL-6, NF-kappaB and the activity of PKC induced by the piliated S. typhi.	decabromobiphenyl ether	40-44	interleukin 6	Homo sapiens	83-87
16164036-7	2005	The PKC inhibitor Dequalinium chloride (DECA) remarkably reduced the production of IL-6, NF-kappaB and the activity of PKC induced by the piliated S. typhi.	decabromobiphenyl ether	40-44	nuclear factor kappa B subunit 1	Homo sapiens	89-98
16164036-7	2005	The PKC inhibitor Dequalinium chloride (DECA) remarkably reduced the production of IL-6, NF-kappaB and the activity of PKC induced by the piliated S. typhi.	decabromobiphenyl ether	40-44	proline rich transmembrane protein 2	Homo sapiens	119-122
14740727-0	2004	Photolytic debromination of decabromodiphenyl ether (BDE 209).	decabromobiphenyl ether	28-51	homeobox D13	Homo sapiens	53-56
15252133-7	2004	Immunoprecipitation with RACK-I antibody co-precipitated fewer PKC-beta in the presence of UV-activated 1, 1"-decamethylenebis-4-aminoquinaldinium di-iodide (DECA), known to disrupt the interaction between activated PKC-beta and RACK-I.	decabromobiphenyl ether	158-162	protein kinase C beta	Homo sapiens	63-71
15252133-8	2004	Treatment of intact melanocytes with DECA also decreased tyrosinase activity.	decabromobiphenyl ether	37-41	tyrosinase	Homo sapiens	57-67
34923383-8	2022	Exposure to BDE47 and BDE209 can lead to the accumulation of ROS in tobacco leaves, but correspondingly, the activities of antioxidant enzymes SOD, POD, CAT, APX and GPX and the up-regulated expression of their coding genes play an important role in preventing excessive oxidative damage.	decabromobiphenyl ether	22-28	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	158-161
12717751-1	2003	The mass spectrometric properties of (12)C-and (13)C-labeled decabromodiphenyl ether (BDE-209) in the low-resolution mass spectrometry electron capture negative ionization mode (ECNI-MS) is described in detail and are compared with those of polybrominated diphenyl ethers (PBDEs) with a lower degree of bromination.	decabromobiphenyl ether	61-84	homeobox D13	Homo sapiens	86-89
8349163-4	1993	We have previously shown that DECA can synergize the in vitro antitumor effects of TNF against a panel of human ovarian cancer cell lines.	decabromobiphenyl ether	30-34	tumor necrosis factor	Homo sapiens	83-86
25784301-1	2015	Facilities adopting anaerobic granular sludge are widely used for the treatment of high strength wastewater, and hence collect many polybrominated diphenyl ethers (PBDEs), especially decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	183-206	homeobox D13	Homo sapiens	165-168
10999942-2	2000	Previously it was shown that PKCalpha activity in vitro could be irreversibly inhibited when treated with DECA at low micromolar concentrations and irradiated with 366 nm of light.	decabromobiphenyl ether	106-110	protein kinase C, alpha	Mus musculus	29-37
10999942-5	2000	Because PKCalpha is the only conventional PKC isoform detected in B16 F10 cells, a stably transfected clone expressing a kinase-defective mutant of PKCalpha was developed that exhibited a substantial loss of adhesion and motility and was refractory to further inhibition by DECA.	decabromobiphenyl ether	274-278	protein kinase C, alpha	Mus musculus	148-156
10753478-2	2000	In vitro assays of monomeric and dimeric analogues support a model in which DECA inhibits PKC(alpha) by an obligatory two-point contact, a unique mechanism among PKC inhibitors.	decabromobiphenyl ether	76-80	protein kinase C alpha	Homo sapiens	90-100
10753478-2	2000	In vitro assays of monomeric and dimeric analogues support a model in which DECA inhibits PKC(alpha) by an obligatory two-point contact, a unique mechanism among PKC inhibitors.	decabromobiphenyl ether	76-80	protein kinase C alpha	Homo sapiens	90-93
21573338-6	1993	We demonstrate that TNF and DECA strongly synergize in vitro at clinically achievable doses for TNF and potentially clinically achievable doses for DECA.	decabromobiphenyl ether	28-32	tumor necrosis factor	Homo sapiens	96-99
21573338-11	1993	DECA, as a mitochondrial poison is an agent capable of potentiating the effects of tumor necrosis factor against ovarian cancer cell lines.	decabromobiphenyl ether	0-4	tumor necrosis factor	Homo sapiens	83-104
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	decabromobiphenyl ether	39-47	mitogen activated protein kinase 3	Rattus norvegicus	235-241
34632857-7	2021	In contrast, IGF-1 treatment antagonized the cytotoxic effects of PBDE-209 in H-NSCs in vitro.	decabromobiphenyl ether	66-74	insulin-like growth factor 1	Rattus norvegicus	13-18
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	decabromobiphenyl ether	39-47	insulin-like growth factor 1	Rattus norvegicus	19-24
34748805-6	2022	Finally, the increased abundance of cellular pivotal Ca2+ signals transducer CaM, activating Ca2+ release channel Sig-1R and IP3R1, and the stronger fluorescence density of mitochondria-specifically Ca2+ labeled probe Rhod-2 in vitro, we summarized that there was overloaded mitochondrial Ca2+ in hepatocytes of BDE-209 treated mice.	decabromobiphenyl ether	312-319	sigma non-opioid intracellular receptor 1	Mus musculus	114-120
34748805-6	2022	Finally, the increased abundance of cellular pivotal Ca2+ signals transducer CaM, activating Ca2+ release channel Sig-1R and IP3R1, and the stronger fluorescence density of mitochondria-specifically Ca2+ labeled probe Rhod-2 in vitro, we summarized that there was overloaded mitochondrial Ca2+ in hepatocytes of BDE-209 treated mice.	decabromobiphenyl ether	312-319	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	125-130
34936917-11	2022	The recombination markers, including DMC1 and RAD51, and crossover marker MLH1 were decreased during spermatogenesis after exposure to BDE-209.	decabromobiphenyl ether	135-142	DNA meiotic recombinase 1	Mus musculus	37-41
34936917-11	2022	The recombination markers, including DMC1 and RAD51, and crossover marker MLH1 were decreased during spermatogenesis after exposure to BDE-209.	decabromobiphenyl ether	135-142	RAD51 recombinase	Mus musculus	46-51
34936917-11	2022	The recombination markers, including DMC1 and RAD51, and crossover marker MLH1 were decreased during spermatogenesis after exposure to BDE-209.	decabromobiphenyl ether	135-142	mutL homolog 1	Mus musculus	74-78
34624399-3	2022	Firstly, the increasing levels of triacylglycerol and proinflammatory factors in the liver and ALT and AST in serum demonstrated the hepatic damage caused by BDE-209 and further exacerbated by HFD.	decabromobiphenyl ether	158-165	solute carrier family 17 member 5	Homo sapiens	103-106
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	decabromobiphenyl ether	39-47	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	decabromobiphenyl ether	39-47	Eph receptor B1	Rattus norvegicus	125-128
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	decabromobiphenyl ether	39-47	insulin-like growth factor 1	Rattus norvegicus	179-184
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	decabromobiphenyl ether	39-47	AKT serine/threonine kinase 1	Rattus norvegicus	204-207
34632857-9	2021	CONCLUSION: Prenatal PBDE-209 exposure impaired the learning and memory ability of rats, whereas IGF-1 treatment was able to inhibit the neurodevelopmental toxicity of PBDE-209 by activation of the PI3K/AKT and ERK1/2 cell pathways.	decabromobiphenyl ether	21-29	AKT serine/threonine kinase 1	Rattus norvegicus	203-206
34632857-9	2021	CONCLUSION: Prenatal PBDE-209 exposure impaired the learning and memory ability of rats, whereas IGF-1 treatment was able to inhibit the neurodevelopmental toxicity of PBDE-209 by activation of the PI3K/AKT and ERK1/2 cell pathways.	decabromobiphenyl ether	21-29	mitogen activated protein kinase 3	Rattus norvegicus	211-217
34632857-9	2021	CONCLUSION: Prenatal PBDE-209 exposure impaired the learning and memory ability of rats, whereas IGF-1 treatment was able to inhibit the neurodevelopmental toxicity of PBDE-209 by activation of the PI3K/AKT and ERK1/2 cell pathways.	decabromobiphenyl ether	168-176	insulin-like growth factor 1	Rattus norvegicus	97-102
34632857-9	2021	CONCLUSION: Prenatal PBDE-209 exposure impaired the learning and memory ability of rats, whereas IGF-1 treatment was able to inhibit the neurodevelopmental toxicity of PBDE-209 by activation of the PI3K/AKT and ERK1/2 cell pathways.	decabromobiphenyl ether	168-176	AKT serine/threonine kinase 1	Rattus norvegicus	203-206
34632857-9	2021	CONCLUSION: Prenatal PBDE-209 exposure impaired the learning and memory ability of rats, whereas IGF-1 treatment was able to inhibit the neurodevelopmental toxicity of PBDE-209 by activation of the PI3K/AKT and ERK1/2 cell pathways.	decabromobiphenyl ether	168-176	mitogen activated protein kinase 3	Rattus norvegicus	211-217
34571075-0	2021	AhR-mediated CYP1A1 and ROS overexpression are involved in hepatotoxicity of decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	102-109	aryl hydrocarbon receptor	Homo sapiens	0-3
34607665-8	2021	qRT-PCR validation demonstrated the involvement of p53-dependent DNA damage response in the GC-2 cells after BDE-209 exposure.	decabromobiphenyl ether	109-116	transformation related protein 53, pseudogene	Mus musculus	51-54
34571075-0	2021	AhR-mediated CYP1A1 and ROS overexpression are involved in hepatotoxicity of decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	77-100	aryl hydrocarbon receptor	Homo sapiens	0-3
34571075-0	2021	AhR-mediated CYP1A1 and ROS overexpression are involved in hepatotoxicity of decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	102-109	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
34571075-0	2021	AhR-mediated CYP1A1 and ROS overexpression are involved in hepatotoxicity of decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	77-100	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
34571075-6	2021	The up-regulation of the Aryl hydrocarbon receptor (AhR)/cytochrome P4501A1 (CYP1A1) signaling pathway indicates that after long-term and high-dose exposure, BDE-209 may be a liver carcinogen.	decabromobiphenyl ether	158-165	aryl hydrocarbon receptor	Homo sapiens	25-50
34571075-6	2021	The up-regulation of the Aryl hydrocarbon receptor (AhR)/cytochrome P4501A1 (CYP1A1) signaling pathway indicates that after long-term and high-dose exposure, BDE-209 may be a liver carcinogen.	decabromobiphenyl ether	158-165	aryl hydrocarbon receptor	Homo sapiens	52-55
34571075-6	2021	The up-regulation of the Aryl hydrocarbon receptor (AhR)/cytochrome P4501A1 (CYP1A1) signaling pathway indicates that after long-term and high-dose exposure, BDE-209 may be a liver carcinogen.	decabromobiphenyl ether	158-165	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	57-75
34571075-6	2021	The up-regulation of the Aryl hydrocarbon receptor (AhR)/cytochrome P4501A1 (CYP1A1) signaling pathway indicates that after long-term and high-dose exposure, BDE-209 may be a liver carcinogen.	decabromobiphenyl ether	158-165	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	77-83
34571075-7	2021	Interestingly, HepG2 cells attempt to metabolize BDE-209 through the Nrf2-mediated antioxidant pathway.	decabromobiphenyl ether	49-56	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
35266255-0	2022	Decabromodiphenyl ether induces ROS-mediated intestinal toxicity through the Keap1-Nrf2 pathway.	decabromobiphenyl ether	0-23	kelch like ECH associated protein 1	Homo sapiens	77-82
34166751-7	2021	Our data indicate that placental Dio3 may be a potential molecular target for future study of BDE209 developmental toxicity.	decabromobiphenyl ether	94-100	iodothyronine deiodinase 3	Homo sapiens	33-37
35066031-7	2022	Phe and BDE209 were the significant contributor to the AhR-mediated risk induced by PAHs and PBDEs, respectively.	decabromobiphenyl ether	8-14	aryl hydrocarbon receptor	Homo sapiens	55-58
34301425-0	2021	Corrigendum to "Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure" (Toxicology 458 (2021)).	decabromobiphenyl ether	190-213	delta like non-canonical Notch ligand 1	Homo sapiens	35-39
34301425-0	2021	Corrigendum to "Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure" (Toxicology 458 (2021)).	decabromobiphenyl ether	190-213	iodothyronine deiodinase 3	Homo sapiens	40-44
34301425-0	2021	Corrigendum to "Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure" (Toxicology 458 (2021)).	decabromobiphenyl ether	190-213	iodothyronine deiodinase 3	Homo sapiens	85-89
34301425-0	2021	Corrigendum to "Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure" (Toxicology 458 (2021)).	decabromobiphenyl ether	215-221	delta like non-canonical Notch ligand 1	Homo sapiens	35-39
34301425-0	2021	Corrigendum to "Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure" (Toxicology 458 (2021)).	decabromobiphenyl ether	215-221	iodothyronine deiodinase 3	Homo sapiens	40-44
34166751-0	2021	Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure.	decabromobiphenyl ether	174-197	delta like non-canonical Notch ligand 1	Homo sapiens	19-23
34166751-0	2021	Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure.	decabromobiphenyl ether	174-197	iodothyronine deiodinase 3	Homo sapiens	24-28
34166751-0	2021	Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure.	decabromobiphenyl ether	174-197	iodothyronine deiodinase 3	Homo sapiens	69-73
34166751-0	2021	Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure.	decabromobiphenyl ether	199-205	delta like non-canonical Notch ligand 1	Homo sapiens	19-23
34166751-0	2021	Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure.	decabromobiphenyl ether	199-205	iodothyronine deiodinase 3	Homo sapiens	24-28
34166751-0	2021	Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure.	decabromobiphenyl ether	199-205	iodothyronine deiodinase 3	Homo sapiens	69-73
34166751-2	2021	Our previous in vivo studies have suggested that developmental neurotoxicity in offspring may be the result of BDE209-induced placental type III iodothyronine deiodinase (Dio3) disturbance and consequent thyroid hormone (TH) instability.	decabromobiphenyl ether	111-117	iodothyronine deiodinase 3	Homo sapiens	171-175
34166751-4	2021	In this study, we used placenta-derived cells to investigate how BDE209 affected Dio3 expression through interfering imprinting mechanisms in the delta-like homolog 1 (DLK1)-Dio3 imprinted region.	decabromobiphenyl ether	65-71	iodothyronine deiodinase 3	Homo sapiens	81-85
34166751-4	2021	In this study, we used placenta-derived cells to investigate how BDE209 affected Dio3 expression through interfering imprinting mechanisms in the delta-like homolog 1 (DLK1)-Dio3 imprinted region.	decabromobiphenyl ether	65-71	delta like non-canonical Notch ligand 1	Homo sapiens	146-166
34166751-6	2021	The sodium bisulfite-clonal sequencing revealed the BDE209 affect methylation status of two differentially methylated regions (DMRs), intergenic-DMR (IG-DMR) and maternally expressed gene 3-DMR (Meg3-DMR).	decabromobiphenyl ether	52-58	maternally expressed 3	Homo sapiens	195-199
35266255-0	2022	Decabromodiphenyl ether induces ROS-mediated intestinal toxicity through the Keap1-Nrf2 pathway.	decabromobiphenyl ether	0-23	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
35182797-0	2022	Gestational exposure to BDE-209 induces placental injury via the endoplasmic reticulum stress-mediated PERK/ATF4/CHOP signaling pathway.	decabromobiphenyl ether	24-31	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	103-107
35182797-0	2022	Gestational exposure to BDE-209 induces placental injury via the endoplasmic reticulum stress-mediated PERK/ATF4/CHOP signaling pathway.	decabromobiphenyl ether	24-31	activating transcription factor 4	Homo sapiens	108-112
35182797-0	2022	Gestational exposure to BDE-209 induces placental injury via the endoplasmic reticulum stress-mediated PERK/ATF4/CHOP signaling pathway.	decabromobiphenyl ether	24-31	DNA damage inducible transcript 3	Homo sapiens	113-117
6790872-4	1981	The PCB standards were used to unambiguously identify the deca-, nona-, and octachlorobiphenyls present in human breast milk and in the commercial PCB preparations Arociors 1268, 1262, 1260, 1254, 1248, 1242, 1016, 1232 and 1221 utilizing high resolution glass capillary gas chromatography.	decabromobiphenyl ether	58-62	pyruvate carboxylase	Homo sapiens	4-7
35007761-0	2022	Decabromodiphenyl ether-induced PRKACA Hypermethylation Contributed to Glycolipid Metabolism Disorder via Regulating PKA/AMPK Pathway in Rat and L-02 Cells.	decabromobiphenyl ether	0-23	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	32-38
35007761-0	2022	Decabromodiphenyl ether-induced PRKACA Hypermethylation Contributed to Glycolipid Metabolism Disorder via Regulating PKA/AMPK Pathway in Rat and L-02 Cells.	decabromobiphenyl ether	0-23	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	121-125
35007761-4	2022	BDE-209 exposure changed the PKA, p-PKA, AMPK, p-AMPK, ACC, and FAS expression in rats" liver and L-02 cells.	decabromobiphenyl ether	0-7	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	41-45
35007761-4	2022	BDE-209 exposure changed the PKA, p-PKA, AMPK, p-AMPK, ACC, and FAS expression in rats" liver and L-02 cells.	decabromobiphenyl ether	0-7	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	49-53
35007761-6	2022	AMPK activator (AICAR) inhibited the changes of p-AMPK, ACC, and FAS expression and elevation of glucose and triglyceride levels induced by BDE-209.	decabromobiphenyl ether	140-147	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	50-54
35007761-7	2022	DNA methylation inhibitor (5-Aza-CdR) reversed BDE-209 induced alters of PKA/AMPK/ACC/FAS signaling pathway.	decabromobiphenyl ether	47-54	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	77-81
35007761-8	2022	These results demonstrated that BDE-209 could disrupt the glycolipid metabolism by causing PRKACA-1 hypermethylation to regulate the PKA/AMPK signaling pathway in hepatocytes.	decabromobiphenyl ether	32-39	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	137-141
35149409-1	2022	Decabromodiphenyl ether (BDE-209) has drawn significant attention due to its suppression of immune functions in animals and even humans.	decabromobiphenyl ether	0-23	homeobox D13	Homo sapiens	25-28
35149409-4	2022	The activities of catalase, glutathione, glutathione peroxidase, and superoxide dismutase in both the spleen and serum were affected by BDE-209.	decabromobiphenyl ether	136-143	catalase	Homo sapiens	18-26
33675858-6	2021	Results showed that luteolin mitigated BDE-209-induced damage to intestinal epithelial barrier by reducing the levels of reactive oxygen species (ROS), increasing the activity of superoxide dismutase (SOD) and glutathione (GSH), suppressed the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta), and increased the expression of tight junction (TJ) proteins (ZO-1, occludin, and claudin-1).	decabromobiphenyl ether	39-46	tumor necrosis factor	Homo sapiens	285-294
34029840-1	2021	The wide usage of decabromodiphenyl ether (BDE-209) results in its increasing occurrence in the environment and increasing attention in regard to human and animal health.	decabromobiphenyl ether	18-41	homeobox D13	Homo sapiens	43-46
33675858-6	2021	Results showed that luteolin mitigated BDE-209-induced damage to intestinal epithelial barrier by reducing the levels of reactive oxygen species (ROS), increasing the activity of superoxide dismutase (SOD) and glutathione (GSH), suppressed the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta), and increased the expression of tight junction (TJ) proteins (ZO-1, occludin, and claudin-1).	decabromobiphenyl ether	39-46	interleukin 6	Homo sapiens	296-300
33675858-6	2021	Results showed that luteolin mitigated BDE-209-induced damage to intestinal epithelial barrier by reducing the levels of reactive oxygen species (ROS), increasing the activity of superoxide dismutase (SOD) and glutathione (GSH), suppressed the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta), and increased the expression of tight junction (TJ) proteins (ZO-1, occludin, and claudin-1).	decabromobiphenyl ether	39-46	interleukin 1 alpha	Homo sapiens	306-314
33675858-6	2021	Results showed that luteolin mitigated BDE-209-induced damage to intestinal epithelial barrier by reducing the levels of reactive oxygen species (ROS), increasing the activity of superoxide dismutase (SOD) and glutathione (GSH), suppressed the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta), and increased the expression of tight junction (TJ) proteins (ZO-1, occludin, and claudin-1).	decabromobiphenyl ether	39-46	tight junction protein 1	Homo sapiens	379-383
33675858-6	2021	Results showed that luteolin mitigated BDE-209-induced damage to intestinal epithelial barrier by reducing the levels of reactive oxygen species (ROS), increasing the activity of superoxide dismutase (SOD) and glutathione (GSH), suppressed the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta), and increased the expression of tight junction (TJ) proteins (ZO-1, occludin, and claudin-1).	decabromobiphenyl ether	39-46	occludin	Homo sapiens	385-393
33675858-6	2021	Results showed that luteolin mitigated BDE-209-induced damage to intestinal epithelial barrier by reducing the levels of reactive oxygen species (ROS), increasing the activity of superoxide dismutase (SOD) and glutathione (GSH), suppressed the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta), and increased the expression of tight junction (TJ) proteins (ZO-1, occludin, and claudin-1).	decabromobiphenyl ether	39-46	claudin 1	Homo sapiens	399-408
32028153-1	2020	The thermal processes of cement kilns are sources of polybrominated dibenzofurans and dioxins (PBDD/Fs); however, when co-processing decabromodiphenyl ether (BDE-209) soil in cement kilns, very few reports have investigated the mechanism of PBDD/Fs formation from BDE-209.	decabromobiphenyl ether	133-156	homeobox D13	Homo sapiens	158-161
33138992-7	2021	Moreover, GW9662, a PPARgamma inhibitor, blocked lipid accumulation and the upregulation of the mTOR/PPARgamma/RXRalpha pathway in L02 cells induced by BDE-209 by relieving the increases in p-mTOR, PPARgamma, and RXRalpha protein expression levels.	decabromobiphenyl ether	152-159	peroxisome proliferator activated receptor gamma	Homo sapiens	20-29
33138992-7	2021	Moreover, GW9662, a PPARgamma inhibitor, blocked lipid accumulation and the upregulation of the mTOR/PPARgamma/RXRalpha pathway in L02 cells induced by BDE-209 by relieving the increases in p-mTOR, PPARgamma, and RXRalpha protein expression levels.	decabromobiphenyl ether	152-159	mechanistic target of rapamycin kinase	Homo sapiens	96-100
33138992-7	2021	Moreover, GW9662, a PPARgamma inhibitor, blocked lipid accumulation and the upregulation of the mTOR/PPARgamma/RXRalpha pathway in L02 cells induced by BDE-209 by relieving the increases in p-mTOR, PPARgamma, and RXRalpha protein expression levels.	decabromobiphenyl ether	152-159	peroxisome proliferator activated receptor gamma	Homo sapiens	101-110
33138992-7	2021	Moreover, GW9662, a PPARgamma inhibitor, blocked lipid accumulation and the upregulation of the mTOR/PPARgamma/RXRalpha pathway in L02 cells induced by BDE-209 by relieving the increases in p-mTOR, PPARgamma, and RXRalpha protein expression levels.	decabromobiphenyl ether	152-159	retinoid X receptor alpha	Homo sapiens	111-119
33138992-7	2021	Moreover, GW9662, a PPARgamma inhibitor, blocked lipid accumulation and the upregulation of the mTOR/PPARgamma/RXRalpha pathway in L02 cells induced by BDE-209 by relieving the increases in p-mTOR, PPARgamma, and RXRalpha protein expression levels.	decabromobiphenyl ether	152-159	mechanistic target of rapamycin kinase	Homo sapiens	192-196
33138992-7	2021	Moreover, GW9662, a PPARgamma inhibitor, blocked lipid accumulation and the upregulation of the mTOR/PPARgamma/RXRalpha pathway in L02 cells induced by BDE-209 by relieving the increases in p-mTOR, PPARgamma, and RXRalpha protein expression levels.	decabromobiphenyl ether	152-159	peroxisome proliferator activated receptor gamma	Homo sapiens	101-110
33138992-7	2021	Moreover, GW9662, a PPARgamma inhibitor, blocked lipid accumulation and the upregulation of the mTOR/PPARgamma/RXRalpha pathway in L02 cells induced by BDE-209 by relieving the increases in p-mTOR, PPARgamma, and RXRalpha protein expression levels.	decabromobiphenyl ether	152-159	retinoid X receptor alpha	Homo sapiens	213-221
33138992-8	2021	In summary, this study revealed that BDE-209 disrupted glycolipid metabolism by inhibiting the PI3K/AKT/GLUT4 pathway and activating the mTOR/PPARgamma/RXRalpha pathway.	decabromobiphenyl ether	37-44	AKT serine/threonine kinase 1	Homo sapiens	100-103
33138992-8	2021	In summary, this study revealed that BDE-209 disrupted glycolipid metabolism by inhibiting the PI3K/AKT/GLUT4 pathway and activating the mTOR/PPARgamma/RXRalpha pathway.	decabromobiphenyl ether	37-44	solute carrier family 2 member 4	Homo sapiens	104-109
33138992-8	2021	In summary, this study revealed that BDE-209 disrupted glycolipid metabolism by inhibiting the PI3K/AKT/GLUT4 pathway and activating the mTOR/PPARgamma/RXRalpha pathway.	decabromobiphenyl ether	37-44	mechanistic target of rapamycin kinase	Homo sapiens	137-141
33138992-8	2021	In summary, this study revealed that BDE-209 disrupted glycolipid metabolism by inhibiting the PI3K/AKT/GLUT4 pathway and activating the mTOR/PPARgamma/RXRalpha pathway.	decabromobiphenyl ether	37-44	peroxisome proliferator activated receptor gamma	Homo sapiens	142-151
33138992-8	2021	In summary, this study revealed that BDE-209 disrupted glycolipid metabolism by inhibiting the PI3K/AKT/GLUT4 pathway and activating the mTOR/PPARgamma/RXRalpha pathway.	decabromobiphenyl ether	37-44	retinoid X receptor alpha	Homo sapiens	152-160
33139011-5	2021	Decabromodiphenyl ether and decabromodiphenylethane were the predominant BDE and AHFR components, respectively, agreeing well with the production and usage patterns of flame retardants in China.	decabromobiphenyl ether	0-23	homeobox D13	Homo sapiens	73-76
33671620-6	2021	As compared with the control, BDE-209 exposure significantly increased abdominal fat percentages of broilers at 64.9-159.5% and adversely affected the selected biochemical indicators, including alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine (CRE), which indicated its toxicity to liver and kidney functions.	decabromobiphenyl ether	30-37	alkaline phosphatase, placental	Homo sapiens	194-214
33671620-6	2021	As compared with the control, BDE-209 exposure significantly increased abdominal fat percentages of broilers at 64.9-159.5% and adversely affected the selected biochemical indicators, including alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine (CRE), which indicated its toxicity to liver and kidney functions.	decabromobiphenyl ether	30-37	alkaline phosphatase, placental	Homo sapiens	216-219
33671620-6	2021	As compared with the control, BDE-209 exposure significantly increased abdominal fat percentages of broilers at 64.9-159.5% and adversely affected the selected biochemical indicators, including alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine (CRE), which indicated its toxicity to liver and kidney functions.	decabromobiphenyl ether	30-37	solute carrier family 17 member 5	Homo sapiens	222-248
33671620-6	2021	As compared with the control, BDE-209 exposure significantly increased abdominal fat percentages of broilers at 64.9-159.5% and adversely affected the selected biochemical indicators, including alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine (CRE), which indicated its toxicity to liver and kidney functions.	decabromobiphenyl ether	30-37	solute carrier family 17 member 5	Homo sapiens	250-253
33671620-6	2021	As compared with the control, BDE-209 exposure significantly increased abdominal fat percentages of broilers at 64.9-159.5% and adversely affected the selected biochemical indicators, including alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine (CRE), which indicated its toxicity to liver and kidney functions.	decabromobiphenyl ether	30-37	glutamic--pyruvic transaminase	Homo sapiens	256-280
33396158-6	2021	The results showed that the concentrations of blood urea nitrogen (BUN), creatinine (CRE) and the neutrophil gelatinase-associated lipocalin (NGAL), significantly increased after exposure to BDE-209 with the doses more than 0.04 g/kg.	decabromobiphenyl ether	191-198	lipocalin 2	Homo sapiens	98-140
33396158-6	2021	The results showed that the concentrations of blood urea nitrogen (BUN), creatinine (CRE) and the neutrophil gelatinase-associated lipocalin (NGAL), significantly increased after exposure to BDE-209 with the doses more than 0.04 g/kg.	decabromobiphenyl ether	191-198	lipocalin 2	Homo sapiens	142-146
32328811-3	2020	The results showed that the most abundant BDE congener in river sediment was BDE209, followed by BDE99 and BDE47, with median values of 48.7, 2.17, and 1.52 ng g-1, respectively.	decabromobiphenyl ether	77-83	homeobox D13	Homo sapiens	42-45
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	77-84	insulin like growth factor 1	Homo sapiens	13-18
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	77-84	AKT serine/threonine kinase 1	Homo sapiens	45-48
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	77-84	AKT serine/threonine kinase 1	Homo sapiens	198-201
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	77-84	solute carrier family 2 member 4	Homo sapiens	202-207
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	77-84	isoleucyl-tRNA synthetase 1	Homo sapiens	275-278
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	77-84	AKT serine/threonine kinase 1	Homo sapiens	198-201
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	77-84	AKT serine/threonine kinase 1	Homo sapiens	198-201
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	77-84	solute carrier family 2 member 4	Homo sapiens	302-307
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	178-185	insulin like growth factor 1	Homo sapiens	13-18
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	178-185	AKT serine/threonine kinase 1	Homo sapiens	45-48
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	178-185	AKT serine/threonine kinase 1	Homo sapiens	198-201
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	178-185	solute carrier family 2 member 4	Homo sapiens	202-207
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	178-185	isoleucyl-tRNA synthetase 1	Homo sapiens	275-278
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	178-185	AKT serine/threonine kinase 1	Homo sapiens	198-201
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	178-185	AKT serine/threonine kinase 1	Homo sapiens	198-201
33138992-6	2021	Furthermore, IGF-1, an activator of the PI3K-AKT pathway, markedly inhibited BDE-209-induced glucose concentration increase in L02 cells and antagonized the inhibitory effect of BDE-209 on the PI3K/AKT/GLUT4 pathway by counteracting the changes in the expression levels of p-IRS, AKT, PI3K, p-AKT, and GLUT4.	decabromobiphenyl ether	178-185	solute carrier family 2 member 4	Homo sapiens	302-307
32410120-9	2020	DECA may promote glioma cell apoptosis by affecting the expression of NFKB2, HRAS, NF1, CBL, RAF1, and BCL-2 genes.	decabromobiphenyl ether	0-4	nuclear factor kappa B subunit 2	Homo sapiens	70-75
32410120-9	2020	DECA may promote glioma cell apoptosis by affecting the expression of NFKB2, HRAS, NF1, CBL, RAF1, and BCL-2 genes.	decabromobiphenyl ether	0-4	HRas proto-oncogene, GTPase	Homo sapiens	77-81
32410120-9	2020	DECA may promote glioma cell apoptosis by affecting the expression of NFKB2, HRAS, NF1, CBL, RAF1, and BCL-2 genes.	decabromobiphenyl ether	0-4	neurofibromin 1	Homo sapiens	83-86
32410120-9	2020	DECA may promote glioma cell apoptosis by affecting the expression of NFKB2, HRAS, NF1, CBL, RAF1, and BCL-2 genes.	decabromobiphenyl ether	0-4	Cbl proto-oncogene	Homo sapiens	88-91
32410120-9	2020	DECA may promote glioma cell apoptosis by affecting the expression of NFKB2, HRAS, NF1, CBL, RAF1, and BCL-2 genes.	decabromobiphenyl ether	0-4	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	93-97
32410120-9	2020	DECA may promote glioma cell apoptosis by affecting the expression of NFKB2, HRAS, NF1, CBL, RAF1, and BCL-2 genes.	decabromobiphenyl ether	0-4	BCL2 apoptosis regulator	Homo sapiens	103-108
31838387-4	2020	The PBDE congener distribution patterns (BDE-209 was the dominant congener) in sediments reflected the occurrence of debromination of BDE-209 and the elution of penta-BDE from the treated products.	decabromobiphenyl ether	41-48	homeobox D13	Homo sapiens	5-8
31421332-5	2019	Such increases may be explained by the stimulatory effects of BDE-209 on alkaline phosphatase (ALP) activity and PMB abundance.	decabromobiphenyl ether	62-69	alkaline phosphatase, placental	Homo sapiens	73-93
31787299-7	2020	Our results showed that both BDE-209 and DBDPE could cause liver morphological changes, induce oxidative stress, increase gamma-glutamyl transferase and glucose levels in serum, and down-regulate PXR, CAR, and CYP3A expression.	decabromobiphenyl ether	29-36	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	196-199
31787299-7	2020	Our results showed that both BDE-209 and DBDPE could cause liver morphological changes, induce oxidative stress, increase gamma-glutamyl transferase and glucose levels in serum, and down-regulate PXR, CAR, and CYP3A expression.	decabromobiphenyl ether	29-36	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	201-204
31787299-7	2020	Our results showed that both BDE-209 and DBDPE could cause liver morphological changes, induce oxidative stress, increase gamma-glutamyl transferase and glucose levels in serum, and down-regulate PXR, CAR, and CYP3A expression.	decabromobiphenyl ether	29-36	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	210-215
31787299-9	2020	The present study indicated that BDE-209 and DBDPE may interfere with normal metabolism in rats through oxidative stress and inflammation, which inhibit PXR and CAR to induce the expression of CYP3A enzymes, and finally produce hepatotoxic effects and cause liver damage in rats.	decabromobiphenyl ether	33-40	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	153-156
31787299-9	2020	The present study indicated that BDE-209 and DBDPE may interfere with normal metabolism in rats through oxidative stress and inflammation, which inhibit PXR and CAR to induce the expression of CYP3A enzymes, and finally produce hepatotoxic effects and cause liver damage in rats.	decabromobiphenyl ether	33-40	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	161-164
31787299-9	2020	The present study indicated that BDE-209 and DBDPE may interfere with normal metabolism in rats through oxidative stress and inflammation, which inhibit PXR and CAR to induce the expression of CYP3A enzymes, and finally produce hepatotoxic effects and cause liver damage in rats.	decabromobiphenyl ether	33-40	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	193-198
31421332-5	2019	Such increases may be explained by the stimulatory effects of BDE-209 on alkaline phosphatase (ALP) activity and PMB abundance.	decabromobiphenyl ether	62-69	alkaline phosphatase, placental	Homo sapiens	95-98
31421332-6	2019	Moreover, based on Miseq sequencing of the phoD gene encoding ALP, Actinobacteria was the dominant PMB phylum in all treatments, and BDE-209 significantly increased the diversity of PMB and altered their community composition.	decabromobiphenyl ether	133-140	alkaline phosphatase, placental	Homo sapiens	62-65
31520908-5	2019	Moreover, BDE-209 could induce oxidative stress with decreased testosterone levels, result in DNA damage and activate DNA damage response signaling pathways (ATM/Chk2, ATR/Chk1 and DNA-PKcs/XRCC4/DNA ligase IV).	decabromobiphenyl ether	10-17	ataxia telangiectasia mutated	Mus musculus	158-161
31639601-4	2019	Lower ratios of BDE209 to Sigma8PBDE and DBDPE to Sigma5AFRs were found in fingernails than in dust.	decabromobiphenyl ether	16-22	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	50-56
31520908-5	2019	Moreover, BDE-209 could induce oxidative stress with decreased testosterone levels, result in DNA damage and activate DNA damage response signaling pathways (ATM/Chk2, ATR/Chk1 and DNA-PKcs/XRCC4/DNA ligase IV).	decabromobiphenyl ether	10-17	checkpoint kinase 2	Mus musculus	162-166
31520908-5	2019	Moreover, BDE-209 could induce oxidative stress with decreased testosterone levels, result in DNA damage and activate DNA damage response signaling pathways (ATM/Chk2, ATR/Chk1 and DNA-PKcs/XRCC4/DNA ligase IV).	decabromobiphenyl ether	10-17	ataxia telangiectasia and Rad3 related	Mus musculus	168-171
31520908-5	2019	Moreover, BDE-209 could induce oxidative stress with decreased testosterone levels, result in DNA damage and activate DNA damage response signaling pathways (ATM/Chk2, ATR/Chk1 and DNA-PKcs/XRCC4/DNA ligase IV).	decabromobiphenyl ether	10-17	checkpoint kinase 1	Mus musculus	172-176
31520908-5	2019	Moreover, BDE-209 could induce oxidative stress with decreased testosterone levels, result in DNA damage and activate DNA damage response signaling pathways (ATM/Chk2, ATR/Chk1 and DNA-PKcs/XRCC4/DNA ligase IV).	decabromobiphenyl ether	10-17	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	181-189
31520908-5	2019	Moreover, BDE-209 could induce oxidative stress with decreased testosterone levels, result in DNA damage and activate DNA damage response signaling pathways (ATM/Chk2, ATR/Chk1 and DNA-PKcs/XRCC4/DNA ligase IV).	decabromobiphenyl ether	10-17	X-ray repair complementing defective repair in Chinese hamster cells 4	Mus musculus	190-195
31520908-5	2019	Moreover, BDE-209 could induce oxidative stress with decreased testosterone levels, result in DNA damage and activate DNA damage response signaling pathways (ATM/Chk2, ATR/Chk1 and DNA-PKcs/XRCC4/DNA ligase IV).	decabromobiphenyl ether	10-17	ligase IV, DNA, ATP-dependent	Mus musculus	196-209
31018474-0	2019	Biodegradation of decabromodiphenyl ether (BDE-209) using a novel microbial consortium GY1: Cells viability, pathway, toxicity assessment, and microbial function prediction.	decabromobiphenyl ether	18-41	homeobox D13	Homo sapiens	43-46
31039416-8	2019	Maternal BDE-209 exposure markedly affected fertility potential, epididymal histology, sialic acid concentration and sperm quality with decreased expression of epididymal Cx43 and AR in these mice offspring.	decabromobiphenyl ether	9-16	gap junction protein, alpha 3	Mus musculus	171-175
30897390-1	2019	In this study, a 200-day deca-brominated diphenyl ether (deca-BDE) degradation activity experiment was carried out, using consumer-use curtain material as the substrate.	decabromobiphenyl ether	25-29	homeobox D13	Homo sapiens	62-65
31018474-0	2019	Biodegradation of decabromodiphenyl ether (BDE-209) using a novel microbial consortium GY1: Cells viability, pathway, toxicity assessment, and microbial function prediction.	decabromobiphenyl ether	18-41	DGCR8 microprocessor complex subunit	Homo sapiens	87-90
31018474-1	2019	GY1, a novel microbial consortium with efficient ability to degrade decabromodiphenyl ether (BDE-209) has been isolated and the sequencing analysis has been conducted.	decabromobiphenyl ether	68-91	DGCR8 microprocessor complex subunit	Homo sapiens	0-3
31018474-1	2019	GY1, a novel microbial consortium with efficient ability to degrade decabromodiphenyl ether (BDE-209) has been isolated and the sequencing analysis has been conducted.	decabromobiphenyl ether	68-91	homeobox D13	Homo sapiens	93-96
30759414-0	2019	A simulation of the seasonal variation of decabromodiphenyl ether in a bay adjacent to the Yellow Sea.	decabromobiphenyl ether	42-65	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	98-101
30759414-1	2019	A three-dimensional transport-ecosystem-POP coupled model is configured to simulate the seasonal variation and budget of decabromodiphenyl ether (BDE-209) in a semi-enclosed bay adjacent to the Yellow Sea.	decabromobiphenyl ether	121-144	homeobox D13	Homo sapiens	146-149
30802833-8	2019	Additionally, BDE-209 and DBDPE led to endothelial dysfunction, as evidenced by the ET-1 and ICAM-1 elevation.	decabromobiphenyl ether	14-21	endothelin 1	Rattus norvegicus	84-88
30784975-0	2019	Remediation of soil co-contaminated with decabromodiphenyl ether (BDE-209) and copper by enhanced electrokinetics-persulfate process.	decabromobiphenyl ether	41-64	homeobox D13	Homo sapiens	66-69
30743236-6	2019	These results suggested that BDE-209 could affect glucose metabolism and inhibiting PI3K/AKT/GLUT4 signaling pathway resulting from improving the p-IRS expression, and interfered with lipid metabolism through activate mTOR/PPARgamma/RXRalpha resulting from oxidative stress in mice.	decabromobiphenyl ether	29-36	thymoma viral proto-oncogene 1	Mus musculus	89-92
30802833-8	2019	Additionally, BDE-209 and DBDPE led to endothelial dysfunction, as evidenced by the ET-1 and ICAM-1 elevation.	decabromobiphenyl ether	14-21	intercellular adhesion molecule 1	Rattus norvegicus	93-99
30743236-6	2019	These results suggested that BDE-209 could affect glucose metabolism and inhibiting PI3K/AKT/GLUT4 signaling pathway resulting from improving the p-IRS expression, and interfered with lipid metabolism through activate mTOR/PPARgamma/RXRalpha resulting from oxidative stress in mice.	decabromobiphenyl ether	29-36	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	93-98
30597220-2	2019	We previously reported that a persistent organic pollutant, decabromodiphenyl ether (BDE-209), can enhance Toll-like receptor 4 (TLR4)-dependent lipid uptake in THP-1 macrophages; whether miRNAs are involved in this process remains unclear.	decabromobiphenyl ether	60-83	homeobox D13	Homo sapiens	85-88
30743236-6	2019	These results suggested that BDE-209 could affect glucose metabolism and inhibiting PI3K/AKT/GLUT4 signaling pathway resulting from improving the p-IRS expression, and interfered with lipid metabolism through activate mTOR/PPARgamma/RXRalpha resulting from oxidative stress in mice.	decabromobiphenyl ether	29-36	isoleucine-tRNA synthetase	Mus musculus	148-151
30743236-6	2019	These results suggested that BDE-209 could affect glucose metabolism and inhibiting PI3K/AKT/GLUT4 signaling pathway resulting from improving the p-IRS expression, and interfered with lipid metabolism through activate mTOR/PPARgamma/RXRalpha resulting from oxidative stress in mice.	decabromobiphenyl ether	29-36	mechanistic target of rapamycin kinase	Mus musculus	218-222
30743236-6	2019	These results suggested that BDE-209 could affect glucose metabolism and inhibiting PI3K/AKT/GLUT4 signaling pathway resulting from improving the p-IRS expression, and interfered with lipid metabolism through activate mTOR/PPARgamma/RXRalpha resulting from oxidative stress in mice.	decabromobiphenyl ether	29-36	peroxisome proliferator activated receptor gamma	Mus musculus	223-232
30743236-6	2019	These results suggested that BDE-209 could affect glucose metabolism and inhibiting PI3K/AKT/GLUT4 signaling pathway resulting from improving the p-IRS expression, and interfered with lipid metabolism through activate mTOR/PPARgamma/RXRalpha resulting from oxidative stress in mice.	decabromobiphenyl ether	29-36	retinoid X receptor alpha	Mus musculus	233-241
30597220-2	2019	We previously reported that a persistent organic pollutant, decabromodiphenyl ether (BDE-209), can enhance Toll-like receptor 4 (TLR4)-dependent lipid uptake in THP-1 macrophages; whether miRNAs are involved in this process remains unclear.	decabromobiphenyl ether	60-83	toll like receptor 4	Homo sapiens	107-127
30597220-2	2019	We previously reported that a persistent organic pollutant, decabromodiphenyl ether (BDE-209), can enhance Toll-like receptor 4 (TLR4)-dependent lipid uptake in THP-1 macrophages; whether miRNAs are involved in this process remains unclear.	decabromobiphenyl ether	60-83	toll like receptor 4	Homo sapiens	129-133
30597220-2	2019	We previously reported that a persistent organic pollutant, decabromodiphenyl ether (BDE-209), can enhance Toll-like receptor 4 (TLR4)-dependent lipid uptake in THP-1 macrophages; whether miRNAs are involved in this process remains unclear.	decabromobiphenyl ether	60-83	GLI family zinc finger 2	Homo sapiens	161-166
28597690-1	2018	The polybrominated diphenyl ether flame retardants decabromodiphenyl ether (BDE-209) and bisphenol A (BPA) are environmental contaminants that can cross the placenta and exert toxicity in the developing fetal nervous system.	decabromobiphenyl ether	51-74	homeobox D13	Homo sapiens	76-79
30408651-2	2019	This study investigated DBP formation in the presence of two types of polybrominated diphenyl ethers (PBDEs), 2,2",4,4"-tetrabromodiphenyl ether (BDE 47) and 2,2",3,3",4,4",5,5",6,6"-decabromodiphenyl ether (BDE 209).	decabromobiphenyl ether	158-206	D-box binding PAR bZIP transcription factor	Homo sapiens	24-27
30565106-1	2019	Deca-bromodiphenyl ether (BDE-209) regulates various aspects of spermatogenesis and male fertility through its effect on estrogen receptor alpha (ERalpha), but the underlying mechanism remains unclear.	decabromobiphenyl ether	0-24	estrogen receptor 1 (alpha)	Mus musculus	121-144
30565106-1	2019	Deca-bromodiphenyl ether (BDE-209) regulates various aspects of spermatogenesis and male fertility through its effect on estrogen receptor alpha (ERalpha), but the underlying mechanism remains unclear.	decabromobiphenyl ether	0-24	estrogen receptor 1 (alpha)	Mus musculus	146-153
30565106-1	2019	Deca-bromodiphenyl ether (BDE-209) regulates various aspects of spermatogenesis and male fertility through its effect on estrogen receptor alpha (ERalpha), but the underlying mechanism remains unclear.	decabromobiphenyl ether	26-33	estrogen receptor 1 (alpha)	Mus musculus	121-144
30565106-1	2019	Deca-bromodiphenyl ether (BDE-209) regulates various aspects of spermatogenesis and male fertility through its effect on estrogen receptor alpha (ERalpha), but the underlying mechanism remains unclear.	decabromobiphenyl ether	26-33	estrogen receptor 1 (alpha)	Mus musculus	146-153
30565106-8	2019	The results identified the role of ERalpha in BTB disruption during spermatogenesis and suggested that BTB disruption occurs because of exposure to BDE-209, which could potentially affect spermatogenesis.	decabromobiphenyl ether	148-155	estrogen receptor 1 (alpha)	Mus musculus	35-42
30232031-0	2018	Decabromodiphenyl ether (BDE-209) enhances foam cell formation in human macrophages via augmenting Toll-like receptor 4-dependent lipid uptake.	decabromobiphenyl ether	0-23	homeobox D13	Homo sapiens	25-28
30232031-0	2018	Decabromodiphenyl ether (BDE-209) enhances foam cell formation in human macrophages via augmenting Toll-like receptor 4-dependent lipid uptake.	decabromobiphenyl ether	0-23	toll like receptor 4	Homo sapiens	99-119
30232031-2	2018	Decabromodiphenyl ether (BDE-209) is a new POP which presents extensively in human populations; whether this contaminant is potentially arteriosclerotic remains unclear.	decabromobiphenyl ether	0-23	homeobox D13	Homo sapiens	25-28
30468867-6	2019	DecaBDE exposure significantly reduced mRNA levels of glucose transporter 4 and thyroid hormone receptor alpha in skeletal muscle and mechanistic target of rapamycin complex 2 in brown adipose tissue compared with vehicle exposure under HFD-feeding.	decabromobiphenyl ether	0-7	thyroid hormone receptor alpha	Mus musculus	54-110
29777253-4	2018	In line with previous reports, the Glow-AGT assay showed that mitochondrial transport inhibitors DECA and monensin increased peroxisomal localization of the mutant.	decabromobiphenyl ether	97-101	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	40-43
28884398-3	2018	Currently, decabromodiphenyl ether (BDE 209) is the only PBDE permitted for production in most countries.	decabromobiphenyl ether	11-34	homeobox D13	Homo sapiens	36-39
29964986-8	2018	BDE-2 (65.80%) composed the main part of PBEDs in the surface water, and it mainly originated from atmospheric long-distance transmission and degradation of high brominated diphenyl ethers; BDE-209 (63.82%) constituted the main part of PBDEs in the surface sediment, and it mainly originated from the commercial Deca-BDEs.	decabromobiphenyl ether	190-197	parathyroid hormone like hormone	Homo sapiens	0-5
29964986-8	2018	BDE-2 (65.80%) composed the main part of PBEDs in the surface water, and it mainly originated from atmospheric long-distance transmission and degradation of high brominated diphenyl ethers; BDE-209 (63.82%) constituted the main part of PBDEs in the surface sediment, and it mainly originated from the commercial Deca-BDEs.	decabromobiphenyl ether	312-321	parathyroid hormone like hormone	Homo sapiens	0-5
29054623-5	2018	In the sediment samples, DBDPE was the predominant flame retardant (39.5ng/g dw), followed by decabromodiphenyl ether (BDE 209) (2.81ng/g dw).	decabromobiphenyl ether	94-117	homeobox D13	Homo sapiens	119-122
29261294-1	2018	In this study, we examined the photodegradation of decabromodiphenyl ether (BDE-209) on the surface of car seat covers from end-of-life vehicles (ELVs).	decabromobiphenyl ether	51-74	homeobox D13	Homo sapiens	76-79
28609849-7	2017	The mean concentration values of DBDPE/BDE-209 in SPM and sediments were apparently higher than those of previous studies.	decabromobiphenyl ether	33-38	homeobox D13	Homo sapiens	39-42
29107227-4	2018	It was found that the inhibition of AMO activities was increased with the increase of decabromodiphenyl ether (BDE 209, 1-100 mg kg-1) and copper (Cu, 50-500 mg kg-1) concentrations.	decabromobiphenyl ether	86-109	homeobox D13	Homo sapiens	111-114
28772138-8	2017	RESULTS: Higher levels of some FRs, particularly decabromodiphenyl ether (BDE-209) and tris(2-chloroethyl) phosphate in dust, were associated with increased odds of PTC.	decabromobiphenyl ether	49-72	homeobox D13	Homo sapiens	74-77
28651164-0	2017	Serum levels of decabromodiphenyl ether (BDE-209) in women from different European countries and possible relationships with lifestyle and diet.	decabromobiphenyl ether	16-39	homeobox D13	Homo sapiens	41-44
28651164-1	2017	To determine possible effects of lifestyle, diet, housing and professional activities on differences in individual levels of decabromodiphenyl ether (BDE-209) in serum of women, 20 to 40years of age, in The Netherlands, the United Kingdom, Norway and Spain.	decabromobiphenyl ether	125-148	homeobox D13	Homo sapiens	150-153
28841423-0	2017	Solid surface-mediated photochemical transformation of decabromodiphenyl ether (BDE-209) in aqueous solution.	decabromobiphenyl ether	55-78	homeobox D13	Homo sapiens	80-83
28841423-2	2017	In this work, the photodegradation of decabromodiphenyl ether (BDE-209) in aqueous system was investigated by preloading it on the surface of various solid matrices.	decabromobiphenyl ether	38-61	homeobox D13	Homo sapiens	63-66
30023692-0	2017	Pollution Status and Human Exposure of Decabromodiphenyl Ether (BDE-209) in China.	decabromobiphenyl ether	39-62	homeobox D13	Homo sapiens	64-67
30023692-1	2017	Decabromodiphenyl ether (BDE-209/decaBDE) is a high-production-volume brominated flame retardant in China, where the decaBDE commercial mixture is manufactured in Laizhou Bay, Shandong Province, even after the prohibition of penta- and octaBDE mixtures.	decabromobiphenyl ether	0-23	homeobox D13	Homo sapiens	25-28
30023692-1	2017	Decabromodiphenyl ether (BDE-209/decaBDE) is a high-production-volume brominated flame retardant in China, where the decaBDE commercial mixture is manufactured in Laizhou Bay, Shandong Province, even after the prohibition of penta- and octaBDE mixtures.	decabromobiphenyl ether	33-40	homeobox D13	Homo sapiens	25-28
30023692-1	2017	Decabromodiphenyl ether (BDE-209/decaBDE) is a high-production-volume brominated flame retardant in China, where the decaBDE commercial mixture is manufactured in Laizhou Bay, Shandong Province, even after the prohibition of penta- and octaBDE mixtures.	decabromobiphenyl ether	117-124	homeobox D13	Homo sapiens	25-28
27639615-3	2017	Decabromodiphenyl ether (BDE 209) and decabromodiphenyl ethane (DBDPE) were the dominant HFRs, with concentrations ranging from 200 to 2150 ng/g and 680-27,400 ng/g, respectively.	decabromobiphenyl ether	0-23	homeobox D13	Homo sapiens	25-28
28572024-0	2017	Maternal exposure to polybrominated diphenyl ether (BDE-209) during lactation affects germ cell survival with altered testicular glucose homeostasis and oxidative status through down-regulation of Cx43 and p27Kip1 in prepubertal mice offspring.	decabromobiphenyl ether	52-59	gap junction protein, alpha 1	Mus musculus	197-201
28572024-0	2017	Maternal exposure to polybrominated diphenyl ether (BDE-209) during lactation affects germ cell survival with altered testicular glucose homeostasis and oxidative status through down-regulation of Cx43 and p27Kip1 in prepubertal mice offspring.	decabromobiphenyl ether	52-59	cyclin-dependent kinase inhibitor 1B	Mus musculus	206-213
28572024-5	2017	The present study, therefore, evaluated the effect of maternal exposure to BDE-209 during lactation on above-mentioned parameters with reference to Cx43 and p27Kip1 in prepubertal Parkes (P) mice offspring.	decabromobiphenyl ether	75-82	gap junction protein, alpha 1	Mus musculus	148-152
28572024-5	2017	The present study, therefore, evaluated the effect of maternal exposure to BDE-209 during lactation on above-mentioned parameters with reference to Cx43 and p27Kip1 in prepubertal Parkes (P) mice offspring.	decabromobiphenyl ether	75-82	cyclin-dependent kinase inhibitor 1B	Mus musculus	157-164
28572024-7	2017	Maternal exposure to BDE-209 during lactation increased germ cell apoptosis with altered expressions of various cell survival and apoptotic markers along with decreased expression of Cx43 and p27Kip1 in prepubertal mice offspring.	decabromobiphenyl ether	21-28	gap junction protein, alpha 1	Mus musculus	183-187
28572024-7	2017	Maternal exposure to BDE-209 during lactation increased germ cell apoptosis with altered expressions of various cell survival and apoptotic markers along with decreased expression of Cx43 and p27Kip1 in prepubertal mice offspring.	decabromobiphenyl ether	21-28	cyclin-dependent kinase inhibitor 1B	Mus musculus	192-199
28464995-0	2017	In vivo reporter gene mutation and micronucleus assays in gpt delta mice treated with a flame retardant decabromodiphenyl ether.	decabromobiphenyl ether	104-127	glutamic pyruvic transaminase, soluble	Mus musculus	58-61
28104350-0	2017	Neonatal exposure to BDE 209 impaired learning and memory, decreased expression of hippocampal core SNAREs and synaptophysin in adult rats.	decabromobiphenyl ether	21-28	synaptophysin	Rattus norvegicus	111-124
27090441-1	2017	Polybrominated diphenyl ethers (PBDEs) exist extensively in the environment as contaminants, in which 2,2",3,3",4,4",5,5",6,6"-decabrominated diphenyl ether (BDE-209) is the most abundant PBDE found in human samples.	decabromobiphenyl ether	102-156	homeobox D13	Homo sapiens	33-36
26602377-10	2016	In conclusion, our results suggest that exposure of BDE-209 to adult mice causes reduction in serum levels of thyroid hormones and altered thyroid status may partly result into impairment of testicular steroidogenesis because of down-regulated expression of SF-1, thereby causing suppression of spermatogenesis.	decabromobiphenyl ether	52-59	splicing factor 1	Mus musculus	258-262
28880749-0	2017	Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death.	decabromobiphenyl ether	12-35	homeobox D13	Homo sapiens	37-40
28880749-5	2017	The aim of this study was to (1) examine the effects of decabromodiphenyl ether (BDE)-209 on different functions of HepG2 cells and (2) investigate whether this congener is involved in mitochondrial toxicity.	decabromobiphenyl ether	56-79	homeobox D13	Homo sapiens	81-84
26854739-8	2016	The SI TeDB-DiPhOBz and BDE-209 powder degradation product mixture also significantly induced CYP1A4 mRNA levels in CEH.	decabromobiphenyl ether	24-31	cytochrome P450 1A4	Gallus gallus	94-100
26682527-2	2016	This study applies our previous animal model simulating occupational exposure to BDE-209 to investigate its potential adverse effects on CD4 T cells.	decabromobiphenyl ether	81-88	CD4 antigen	Mus musculus	137-140
26682527-7	2016	BDE-209 exposure in vitro also suppressed the reactivity of CD4 T cells at concentrations of 0.01, 0.1, 1 and 10 muM.	decabromobiphenyl ether	0-7	CD4 antigen	Mus musculus	60-63
26682527-8	2016	Furthermore, we observed weaker antigen-specific CD4 T-cell responses to Listeria monocytogenes infection in the mice exposed to BDE-209, suggesting decreased resistance to exogenous pathogens.	decabromobiphenyl ether	129-136	CD4 antigen	Mus musculus	49-52
26206603-1	2016	Decabromodiphenyl ether (BDE-209) has been detected in human serum, semen, placenta, cord blood and milk worldwide.	decabromobiphenyl ether	0-23	homeobox D13	Homo sapiens	25-28
25751737-0	2015	Oxidative degradation of decabromodiphenyl ether (BDE 209) by potassium permanganate: reaction pathways, kinetics, and mechanisms assisted by density functional theory calculations.	decabromobiphenyl ether	25-48	homeobox D13	Homo sapiens	50-53
26363326-0	2016	Laboratory study of the particle-size distribution of Decabromodiphenyl ether (BDE-209) in ambient air.	decabromobiphenyl ether	54-77	homeobox D13	Homo sapiens	79-82
26092356-2	2015	The results showed that decabromodiphenyl ether (BDE-209) was the predominant congener, accounting for >98 % of PBDEs in all sediment.	decabromobiphenyl ether	24-47	homeobox D13	Homo sapiens	49-52
25824818-8	2015	Compared with the control and vehicle groups, the mRNA expression of ET-1 and iNOS in the placenta was gradually and significantly increased after exposure to increasing concentrations of PBDE-209 (P<0.05), while the mRNA level of eNOS in the placenta was gradually and significantly reduced after exposure to increasing concentrations of PBDE-209 (P<0.05).	decabromobiphenyl ether	188-196	endothelin 1	Rattus norvegicus	69-73
25824818-8	2015	Compared with the control and vehicle groups, the mRNA expression of ET-1 and iNOS in the placenta was gradually and significantly increased after exposure to increasing concentrations of PBDE-209 (P<0.05), while the mRNA level of eNOS in the placenta was gradually and significantly reduced after exposure to increasing concentrations of PBDE-209 (P<0.05).	decabromobiphenyl ether	188-196	nitric oxide synthase 2	Rattus norvegicus	78-82
25824818-8	2015	Compared with the control and vehicle groups, the mRNA expression of ET-1 and iNOS in the placenta was gradually and significantly increased after exposure to increasing concentrations of PBDE-209 (P<0.05), while the mRNA level of eNOS in the placenta was gradually and significantly reduced after exposure to increasing concentrations of PBDE-209 (P<0.05).	decabromobiphenyl ether	342-350	endothelin 1	Rattus norvegicus	69-73
25824818-8	2015	Compared with the control and vehicle groups, the mRNA expression of ET-1 and iNOS in the placenta was gradually and significantly increased after exposure to increasing concentrations of PBDE-209 (P<0.05), while the mRNA level of eNOS in the placenta was gradually and significantly reduced after exposure to increasing concentrations of PBDE-209 (P<0.05).	decabromobiphenyl ether	342-350	nitric oxide synthase 2	Rattus norvegicus	78-82
26165047-2	2015	BDE-209 exhibits its toxic effects partly through the aryl hydrocarbon (Ah) receptor and consequent induction of hepatic microsomal enzymes.	decabromobiphenyl ether	0-7	aryl hydrocarbon receptor	Rattus norvegicus	54-84
25751737-1	2015	This study found that decabromodiphenyl ether (BDE 209) could be oxidized effectively by potassium permanganate (KMnO4) in sulfuric acid medium.	decabromobiphenyl ether	22-45	homeobox D13	Homo sapiens	47-50
25454222-1	2015	The European Variant Berkeley Trent (EVn-BETR) multimedia fugacity model is used to test the validity of previously derived emission estimates and predict environmental concentrations of the main decabromodiphenyl ether congener, BDE-209.	decabromobiphenyl ether	196-219	homeobox D13	Homo sapiens	230-233
25044829-9	2015	DecaBDE significantly affected (down to 0.4 nM) the number of dendritic branches, and the levels of synaptic proteins and doublecortin in cultured neurons.	decabromobiphenyl ether	0-7	doublecortin	Homo sapiens	122-134
25479311-4	2014	We hypothesized that postnatal exposure to decaBDE may alter levels of serum thyroid hormones (THs) and testosterone, or the level of TH receptor alpha (Thra) transcripts and its splicing variants and androgen receptor (Ar) in Sertoli cells, adversely affecting spermatogenesis.	decabromobiphenyl ether	43-50	thyroid hormone receptor alpha	Mus musculus	153-157
26413122-3	2015	In order to explore the mechanism, present study was designed to examine the role of CDRI-08 on the expression of NMDAR1 (NR1) and the binding of REST/NRSF to NR1 promoter against postnatal exposure of PBDE-209.	decabromobiphenyl ether	202-210	RE1-silencing transcription factor	Mus musculus	151-155
26413122-3	2015	In order to explore the mechanism, present study was designed to examine the role of CDRI-08 on the expression of NMDAR1 (NR1) and the binding of REST/NRSF to NR1 promoter against postnatal exposure of PBDE-209.	decabromobiphenyl ether	202-210	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	159-162
26413122-5	2015	The findings showed upregulated expression of NR1 and decreased binding of REST/NRSF to NR1 promoter after postnatal exposure of PBDE-209.	decabromobiphenyl ether	129-137	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	46-49
26413122-5	2015	The findings showed upregulated expression of NR1 and decreased binding of REST/NRSF to NR1 promoter after postnatal exposure of PBDE-209.	decabromobiphenyl ether	129-137	RE1-silencing transcription factor	Mus musculus	80-84
26413122-5	2015	The findings showed upregulated expression of NR1 and decreased binding of REST/NRSF to NR1 promoter after postnatal exposure of PBDE-209.	decabromobiphenyl ether	129-137	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	88-91
25479311-4	2014	We hypothesized that postnatal exposure to decaBDE may alter levels of serum thyroid hormones (THs) and testosterone, or the level of TH receptor alpha (Thra) transcripts and its splicing variants and androgen receptor (Ar) in Sertoli cells, adversely affecting spermatogenesis.	decabromobiphenyl ether	43-50	androgen receptor	Mus musculus	201-218
25479311-4	2014	We hypothesized that postnatal exposure to decaBDE may alter levels of serum thyroid hormones (THs) and testosterone, or the level of TH receptor alpha (Thra) transcripts and its splicing variants and androgen receptor (Ar) in Sertoli cells, adversely affecting spermatogenesis.	decabromobiphenyl ether	43-50	androgen receptor	Mus musculus	220-222
25479311-6	2014	Levels of serum testosterone and transcripts encoding Ar, Thra, and its variant, Thra1, declined significantly in Sertoli cells of mice exposed to 0.025 mg decaBDE/kg.	decabromobiphenyl ether	156-163	androgen receptor	Mus musculus	54-56
25479311-6	2014	Levels of serum testosterone and transcripts encoding Ar, Thra, and its variant, Thra1, declined significantly in Sertoli cells of mice exposed to 0.025 mg decaBDE/kg.	decabromobiphenyl ether	156-163	thyroid hormone receptor alpha	Mus musculus	58-62
25479311-6	2014	Levels of serum testosterone and transcripts encoding Ar, Thra, and its variant, Thra1, declined significantly in Sertoli cells of mice exposed to 0.025 mg decaBDE/kg.	decabromobiphenyl ether	156-163	thyroid hormone receptor alpha	Mus musculus	81-86
25479311-8	2014	However, the Thra1:Thra2 and Hnrnpa1:Srsf1 ratios were altered in Sertoli cells of mice exposed to 0.025 mg decaBDE/kg but not in cells exposed to 0.25 or 2.5 mg decaBDE/kg.	decabromobiphenyl ether	108-115	thyroid hormone receptor alpha	Mus musculus	13-18
25479311-8	2014	However, the Thra1:Thra2 and Hnrnpa1:Srsf1 ratios were altered in Sertoli cells of mice exposed to 0.025 mg decaBDE/kg but not in cells exposed to 0.25 or 2.5 mg decaBDE/kg.	decabromobiphenyl ether	108-115	serine and arginine-rich splicing factor 1	Mus musculus	37-42
25479311-9	2014	These results indicate that postnatal exposure to a low dose of decaBDE on PNDs 1 through 5 lowers the testosterone level and the levels of Ar and Thra transcripts in Sertoli cells, accompanied by an imbalance in the ratios of Thra splicing variants, resulting in smaller testicular size and impaired spermatogenesis.	decabromobiphenyl ether	64-71	androgen receptor	Mus musculus	140-142
25479311-9	2014	These results indicate that postnatal exposure to a low dose of decaBDE on PNDs 1 through 5 lowers the testosterone level and the levels of Ar and Thra transcripts in Sertoli cells, accompanied by an imbalance in the ratios of Thra splicing variants, resulting in smaller testicular size and impaired spermatogenesis.	decabromobiphenyl ether	64-71	thyroid hormone receptor alpha	Mus musculus	147-151
25479311-9	2014	These results indicate that postnatal exposure to a low dose of decaBDE on PNDs 1 through 5 lowers the testosterone level and the levels of Ar and Thra transcripts in Sertoli cells, accompanied by an imbalance in the ratios of Thra splicing variants, resulting in smaller testicular size and impaired spermatogenesis.	decabromobiphenyl ether	64-71	thyroid hormone receptor alpha	Mus musculus	227-231
24984234-3	2014	In particular, transfer of BFRs to dust via abrasion of particles or fibers from treated products may explain elevated concentrations (up to 210 mg g(-1)) of low volatility BFRs like decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	183-206	homeobox D13	Homo sapiens	208-211
25193018-0	2014	Neurodevelopmental effects of decabromodiphenyl ether (BDE-209) in APOE transgenic mice.	decabromobiphenyl ether	30-53	apolipoprotein E	Mus musculus	67-71
25193018-0	2014	Neurodevelopmental effects of decabromodiphenyl ether (BDE-209) in APOE transgenic mice.	decabromobiphenyl ether	55-62	apolipoprotein E	Mus musculus	67-71
25193018-5	2014	On the basis of our results, the main goal of the current investigation was to assess whether the same exposure to BDE-209 would affect the neurodevelopment of apoE transgenic mice.	decabromobiphenyl ether	115-122	apolipoprotein E	Mus musculus	160-164
25237136-6	2014	We tested whether one promising candidate, Food and Drug Administration (FDA)-approved dequalinium chloride (DECA), could restore proper peroxisomal trafficking of AGT(P11LG170R).	decabromobiphenyl ether	109-113	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	164-167
25237136-7	2014	Indeed, treatment with DECA inhibited AGT(P11LG170R) translocation into mitochondria and subsequently restored trafficking to peroxisomes.	decabromobiphenyl ether	23-27	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	38-41
25237136-12	2014	Thus, repurposing the FDA-approved DECA may be a pharmacologic strategy to treat PH1 patients with mutations in AGT because an additional 75 missense mutations in AGT may also result in mistrafficking.	decabromobiphenyl ether	35-39	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	112-115
24705197-3	2014	In this study, experimental adult mice were intragastrically administered 2,2",3,3",4,4",5,5",6,6"-decabromodiphenyl ether (BDE-209) at doses of 8, 80 or 800 mg/kg of body weight (bw) at 2-day intervals.	decabromobiphenyl ether	74-122	homeobox D13	Homo sapiens	124-127
25511268-1	2014	OBJECTIVE: To study the protective effects of N-acetylcysteine (NAC) against oxidative injury in the brain tissue of mice induced by decabromodiphenyl ether (PBDE-209) and the expression of mitogen activated protein kinase (MAPK)-related proteins in the hippocampus.	decabromobiphenyl ether	133-156	NLR family, pyrin domain containing 1A	Mus musculus	64-67
25511268-1	2014	OBJECTIVE: To study the protective effects of N-acetylcysteine (NAC) against oxidative injury in the brain tissue of mice induced by decabromodiphenyl ether (PBDE-209) and the expression of mitogen activated protein kinase (MAPK)-related proteins in the hippocampus.	decabromobiphenyl ether	158-166	NLR family, pyrin domain containing 1A	Mus musculus	64-67
23999552-0	2013	Long term effects of murine postnatal exposure to decabromodiphenyl ether (BDE-209) on learning and memory are dependent upon APOE polymorphism and age.	decabromobiphenyl ether	50-73	apolipoprotein E	Mus musculus	126-130
24857698-0	2014	Thyroid hormones and fear learning but not anxiety are affected in adult apoE transgenic mice exposed postnatally to decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	117-140	apolipoprotein E	Mus musculus	73-77
24857698-0	2014	Thyroid hormones and fear learning but not anxiety are affected in adult apoE transgenic mice exposed postnatally to decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	117-140	homeobox D13	Homo sapiens	142-145
24239914-2	2014	In the present study, we applied a proteomics approach to study the effects of decabromodiphenyl ether (BDE-209) and/or tetrabromodiphenyl ether (BDE-47) on the expression of proteins extracted from neural stem/progenitor cells and further explored mechanisms on neurodevelopmental toxicity.	decabromobiphenyl ether	79-102	homeobox D13	Homo sapiens	104-107
24291653-3	2014	BDE-209 (the main congener in the decaBDE formulation) was present above the LOQ in 69% of samples (average concentration=0.31ngg(-1) lw).	decabromobiphenyl ether	34-41	homeobox D13	Homo sapiens	0-3
25009812-2	2014	No literature is available on the aerobic biotransformation of decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	63-86	homeobox D13	Homo sapiens	88-91
24643388-1	2014	Debromination of decabromodiphenyl ether (deca-BDE) by microbe and by zero-valent iron (ZVI) has been reported previously.	decabromobiphenyl ether	17-40	homeobox D13	Homo sapiens	47-50
24576782-5	2014	Although the lower brominated BDEs (tri- through hepta-BDEs) in the soil may originate from technical deca-BDE mixtures as trace impurities and/or from the degradation of deca-BDEs, deca-BDE was shown to be persistent in the soil.	decabromobiphenyl ether	171-180	homeobox D13	Homo sapiens	30-33
24576782-5	2014	Although the lower brominated BDEs (tri- through hepta-BDEs) in the soil may originate from technical deca-BDE mixtures as trace impurities and/or from the degradation of deca-BDEs, deca-BDE was shown to be persistent in the soil.	decabromobiphenyl ether	171-180	homeobox D13	Homo sapiens	55-58
24834073-0	2014	Toxic effects of decabromodiphenyl ether (BDE-209) on human embryonic kidney cells.	decabromobiphenyl ether	17-40	homeobox D13	Homo sapiens	42-45
25076541-1	2014	An organo-montmorillonite-supported nanoscale zero-valent iron material (M-NZVI) was synthesized to degrade decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	108-131	homeobox D13	Homo sapiens	133-136
24045004-1	2013	A 60-day growth chamber experiments were performed to investigate the effect of Cu stress on the uptake, translocation and metabolism of decabromodiphenyl ether (BDE-209) by pumpkin.	decabromobiphenyl ether	137-160	homeobox D13	Homo sapiens	162-165
23999552-0	2013	Long term effects of murine postnatal exposure to decabromodiphenyl ether (BDE-209) on learning and memory are dependent upon APOE polymorphism and age.	decabromobiphenyl ether	75-82	apolipoprotein E	Mus musculus	126-130
23999552-9	2013	Postnatal exposure to BDE-209 induced long term effects in spatial learning, which were dependent upon age, sex and apoE genotype; these effects were more evident in apoE3 mice.	decabromobiphenyl ether	22-29	apolipoprotein E	Mus musculus	116-120
23764475-0	2013	Destruction of decabromodiphenyl ether (BDE-209) in a ternary carbonate molten salt reactor.	decabromobiphenyl ether	15-38	homeobox D13	Homo sapiens	40-43
24056914-6	2013	At the higher test temperatures, the proportions of di- to hexa-BDEs in the emissions were clearly larger than in the original sample, suggesting that the textile products treated with technical DecaBDE could be a source of environmentally relevant PBDE congeners such as BDE 47, 99, and 100.	decabromobiphenyl ether	195-202	homeobox D13	Homo sapiens	64-67
23764475-2	2013	In this study, the destruction of decabromodiphenyl ether (BDE-209) in a ternary molten salt (Li, Na, K)2 CO3 reactor was evaluated.	decabromobiphenyl ether	34-57	homeobox D13	Homo sapiens	59-62
23287648-8	2013	DECA group showed enhancement of matrix type I collagen deposition (p < 0.01) and cardiac ACE activity (p < 0.01) compared with the CONT.	decabromobiphenyl ether	0-4	angiotensin I converting enzyme	Rattus norvegicus	93-96
23856315-3	2013	In this study, the removal processes of decabromodiphenyl ether (BDE-209) and monobromodiphenyl ether (BDE-3) with microscale zerovalent iron (MZVI) were investigated to get better understandings for the removal mechanism based upon adsorption and degradation.	decabromobiphenyl ether	40-63	homeobox D13	Homo sapiens	65-68
23914054-3	2013	Vimentin(+) and Ret(+) cell populations increased at >= 100 ppm and >= 10 ppm DBDE, respectively.	decabromobiphenyl ether	84-88	vimentin	Rattus norvegicus	0-8
23914054-3	2013	Vimentin(+) and Ret(+) cell populations increased at >= 100 ppm and >= 10 ppm DBDE, respectively.	decabromobiphenyl ether	84-88	ret proto-oncogene	Rattus norvegicus	16-19
23583986-6	2013	Massive production and/or the use of commercialized deca-BDE (#209) may occur in metropolitan areas and development zones in the YRD.	decabromobiphenyl ether	52-56	homeobox D13	Homo sapiens	57-60
23914054-0	2013	Increased cellular distribution of vimentin and ret in the cingulum of rat offspring after developmental exposure to decabromodiphenyl ether or 1,2,5,6,9,10-hexabromocyclododecane.	decabromobiphenyl ether	117-140	vimentin	Rattus norvegicus	35-43
23914054-0	2013	Increased cellular distribution of vimentin and ret in the cingulum of rat offspring after developmental exposure to decabromodiphenyl ether or 1,2,5,6,9,10-hexabromocyclododecane.	decabromobiphenyl ether	117-140	ret proto-oncogene	Rattus norvegicus	48-51
23287648-10	2013	Cardiac injury was observed in the DECA group shown by the reduction in cardiac troponin I (p < 0.01) compared with the CONT group.	decabromobiphenyl ether	35-39	troponin I3, cardiac type	Rattus norvegicus	72-90
22840536-6	2012	PBDE congeners and homologues analysis and principal component analysis (PCA) also revealed that the major source of PBDE in the soil samples was associated with the prevalent use of technical decabromodiphenyl ether (Deca-BDE) and pentabromodiphenyl ether (Penta-BDE).	decabromobiphenyl ether	193-216	homeobox D13	Homo sapiens	118-121
23354373-5	2013	The oral RfD was markedly greater than Mirex (2x10(-4) mg kg(-1) d(-1)) and decabromodiphenyl ether (BDE-209; 7x10(-3) mg kg(-1) d(-1)), which have been or might be replaced by DP as a flame retardant with less toxicity.	decabromobiphenyl ether	76-99	homeobox D13	Homo sapiens	101-104
22921657-1	2013	This study was conducted to develop a method for the determination of decabromodiphenyl ether (BDE-209) in indoor dust from different microenvironments in a university in the Philippines.	decabromobiphenyl ether	70-93	homeobox D13	Homo sapiens	95-98
23531792-0	2013	Different pathways of constitutive androstane receptor-mediated liver hypertrophy and hepatocarcinogenesis in mice treated with piperonyl butoxide or decabromodiphenyl ether.	decabromobiphenyl ether	150-173	nuclear receptor subfamily 1, group I, member 3	Mus musculus	22-54
23531792-4	2013	In this study, we investigated CAR involvement in liver hypertrophy and hepatocarcinogenesis of Cyp2b-inducing nongenotoxic hepatocarcinogens, piperonyl butoxide (PBO), and decabromodiphenyl ether (DBDE), using wild-type and CAR knockout (CARKO) male mice.	decabromobiphenyl ether	198-202	nuclear receptor subfamily 1, group I, member 3	Mus musculus	31-34
23531792-6	2013	In the wild-type mice, 4-week treatment with PBO, DBDE, or PB induced hepatocellular hypertrophy with increased Cyp2b10 messenger RNA and Cyp2b protein expression.	decabromobiphenyl ether	50-54	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	112-119
23531792-6	2013	In the wild-type mice, 4-week treatment with PBO, DBDE, or PB induced hepatocellular hypertrophy with increased Cyp2b10 messenger RNA and Cyp2b protein expression.	decabromobiphenyl ether	50-54	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	112-117
23531792-11	2013	DBDE may act via CAR-independent pathways during hepatocarcinogenesis.	decabromobiphenyl ether	0-4	nuclear receptor subfamily 1, group I, member 3	Mus musculus	17-20
23194181-0	2012	Deca-brominated diphenyl ether destruction and PBDD/F and PCDD/F emissions from coprocessing deca-BDE mixture-contaminated soils in cement kilns.	decabromobiphenyl ether	0-4	homeobox D13	Homo sapiens	98-101
22595555-1	2012	This study focused on the enhanced debromination of decabromodiphenyl ether (BDE-209) and 2,2",4,4"-tetrabromodiphenyl ether (BDE-47) by Fe-Ag nano-particles under microwave radiation (Fe-Ag/MW).	decabromobiphenyl ether	52-75	homeobox D13	Homo sapiens	77-80
22148267-6	2012	Decabromodiphenyl ether (BDE-209) was the major congener present in all samples followed by nona-BDEs (BDE-207, BDE-206, and BDE-208), both accounting for 89% and 7% of total BDE, respectively.	decabromobiphenyl ether	0-23	homeobox D13	Homo sapiens	25-28
22265595-3	2012	The combined effects of microscale zerovalent iron (MZVI) and anaerobic sludge in decabromodiphenyl ether (BDE-209) degradation were investigated.	decabromobiphenyl ether	82-105	homeobox D13	Homo sapiens	107-110
23038006-0	2012	Postnatal exposure to low-dose decabromodiphenyl ether adversely affects mouse testes by increasing thyrosine phosphorylation level of cortactin.	decabromobiphenyl ether	31-54	cortactin	Mus musculus	135-144
22018855-1	2012	Decabromodiphenyl ethane (DPDPE) is a flame retardant that has been on the market for more than 20 years and is used as a replacement for decabromodiphenyl ether (BDE-209).	decabromobiphenyl ether	138-161	homeobox D13	Homo sapiens	163-166
23038006-7	2012	These findings suggest that postnatal exposure to low-dose decaBDE inhibits mouse testicular development by increasing Tyr phosphorylation of CTTN, although different mechanisms may be involved depending on the dose of decaBDE.	decabromobiphenyl ether	59-66	cortactin	Mus musculus	142-146
23038006-3	2012	We hypothesized that decaBDE affects mouse testes by altering the expression and phosphorylation level of cortactin (CTTN), an F-actin-binding protein that is similar to flutamide, and we performed western blot analyses on testicular samples from mice subcutaneously injected with decaBDE (0.025, 0.25, and 2.5 mg/kg body weight/day) on postnatal days 1 to 5.	decabromobiphenyl ether	21-28	cortactin	Mus musculus	106-115
23038006-3	2012	We hypothesized that decaBDE affects mouse testes by altering the expression and phosphorylation level of cortactin (CTTN), an F-actin-binding protein that is similar to flutamide, and we performed western blot analyses on testicular samples from mice subcutaneously injected with decaBDE (0.025, 0.25, and 2.5 mg/kg body weight/day) on postnatal days 1 to 5.	decabromobiphenyl ether	21-28	cortactin	Mus musculus	117-121
23038006-7	2012	These findings suggest that postnatal exposure to low-dose decaBDE inhibits mouse testicular development by increasing Tyr phosphorylation of CTTN, although different mechanisms may be involved depending on the dose of decaBDE.	decabromobiphenyl ether	219-226	cortactin	Mus musculus	142-146
23038006-3	2012	We hypothesized that decaBDE affects mouse testes by altering the expression and phosphorylation level of cortactin (CTTN), an F-actin-binding protein that is similar to flutamide, and we performed western blot analyses on testicular samples from mice subcutaneously injected with decaBDE (0.025, 0.25, and 2.5 mg/kg body weight/day) on postnatal days 1 to 5.	decabromobiphenyl ether	281-288	cortactin	Mus musculus	106-115
23038006-3	2012	We hypothesized that decaBDE affects mouse testes by altering the expression and phosphorylation level of cortactin (CTTN), an F-actin-binding protein that is similar to flutamide, and we performed western blot analyses on testicular samples from mice subcutaneously injected with decaBDE (0.025, 0.25, and 2.5 mg/kg body weight/day) on postnatal days 1 to 5.	decabromobiphenyl ether	281-288	cortactin	Mus musculus	117-121
23038006-4	2012	Mice treated with low-dose decaBDE (0.025 mg/kg) showed reduced testicular weight, sperm count, elongated spermatid and Sertoli cell numbers, as well as induced Tyr phosphorylation of CTTN and reduced the expression level of p60 Src tyrosine kinase (SRC).	decabromobiphenyl ether	27-34	cortactin	Mus musculus	184-188
23038006-4	2012	Mice treated with low-dose decaBDE (0.025 mg/kg) showed reduced testicular weight, sperm count, elongated spermatid and Sertoli cell numbers, as well as induced Tyr phosphorylation of CTTN and reduced the expression level of p60 Src tyrosine kinase (SRC).	decabromobiphenyl ether	27-34	plasma protein 1	Mus musculus	225-228
23038006-4	2012	Mice treated with low-dose decaBDE (0.025 mg/kg) showed reduced testicular weight, sperm count, elongated spermatid and Sertoli cell numbers, as well as induced Tyr phosphorylation of CTTN and reduced the expression level of p60 Src tyrosine kinase (SRC).	decabromobiphenyl ether	27-34	Rous sarcoma oncogene	Mus musculus	229-232
23038006-4	2012	Mice treated with low-dose decaBDE (0.025 mg/kg) showed reduced testicular weight, sperm count, elongated spermatid and Sertoli cell numbers, as well as induced Tyr phosphorylation of CTTN and reduced the expression level of p60 Src tyrosine kinase (SRC).	decabromobiphenyl ether	27-34	Rous sarcoma oncogene	Mus musculus	250-253
23038006-5	2012	Further, 0.25 and 2.5 mg/kg decaBDE-exposed groups produced an decrease the expression level of CTTN.	decabromobiphenyl ether	28-35	cortactin	Mus musculus	96-100
23038006-6	2012	High-dose decaBDE (2.5 mg/kg) showed increased abnormal germ cells, as well as induced Ser phosphorylation of CTTN and activated extracellular signal-regulated kinase (ERK1/2); however, high-dose decaBDE did not affect testicular weight and sperm count.	decabromobiphenyl ether	10-17	cortactin	Mus musculus	110-114
23038006-6	2012	High-dose decaBDE (2.5 mg/kg) showed increased abnormal germ cells, as well as induced Ser phosphorylation of CTTN and activated extracellular signal-regulated kinase (ERK1/2); however, high-dose decaBDE did not affect testicular weight and sperm count.	decabromobiphenyl ether	10-17	mitogen-activated protein kinase 3	Mus musculus	168-174
21514020-1	2011	The present study shows the occurrence of 2,2",3,3",4,4",5,5",6,6"-decabromodiphenyl ether (BDE-209) in microbial biofilms of Pyrenean and Tatra high mountain lakes despite its low vapor pressure and high hydrophobicity.	decabromobiphenyl ether	42-90	homeobox D13	Homo sapiens	92-95
21183262-0	2011	Behavior of decabromodiphenyl ether (BDE-209) in soil: effects of rhizosphere and mycorrhizal colonization of ryegrass roots.	decabromobiphenyl ether	12-35	homeobox D13	Homo sapiens	37-40
21183262-1	2011	A rhizobox experiment was conducted to investigate degradation of decabromodiphenyl ether (BDE-209) in the rhizosphere of ryegrass and the influence of root colonization with an arbuscular mycorrhizal (AM) fungus.	decabromobiphenyl ether	66-89	homeobox D13	Homo sapiens	91-94
20686340-5	2010	BDE-209 significantly induced the expression of cytochrome P450 (CYP1A2, CYP3A1, and CYP2B1) enzymes in the liver.	decabromobiphenyl ether	0-7	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	48-71
21182867-0	2011	Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant?	decabromobiphenyl ether	3-26	homeobox D13	Homo sapiens	28-31
20581093-5	2010	Higher concentrations of DecaBDE were achieved in plasma and in milk with CO than with SPL.	decabromobiphenyl ether	25-32	sphingosine-1-phosphate lyase 1	Rattus norvegicus	87-90
20686340-5	2010	BDE-209 significantly induced the expression of cytochrome P450 (CYP1A2, CYP3A1, and CYP2B1) enzymes in the liver.	decabromobiphenyl ether	0-7	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	73-79
20686340-5	2010	BDE-209 significantly induced the expression of cytochrome P450 (CYP1A2, CYP3A1, and CYP2B1) enzymes in the liver.	decabromobiphenyl ether	0-7	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	85-91
20299075-4	2010	The PBDE congener compositions were dominated by BDE-209, which is in accordance with the consumption of decaBDE mixture in Korea.	decabromobiphenyl ether	105-112	homeobox D13	Homo sapiens	5-8
20821515-1	2010	The flame retardant decabromodiphenyl ether (BDE 209) accumulates in humans and terrestrial food webs, but few studies have reported the accumulation of BDE 209 in aquatic biota.	decabromobiphenyl ether	20-43	homeobox D13	Homo sapiens	45-48
20821515-2	2010	To investigate the mechanisms controlling the bioavailability of BDE 209, a 28-d bioaccumulation experiment was conducted in which the marine polychaete worm Nereis virens was exposed to a decabromodiphenyl ether (deca-BDE) commercial mixture (>85% BDE 209) in spiked sediments, in spiked food, or in field sediments.	decabromobiphenyl ether	189-212	homeobox D13	Homo sapiens	65-68
20821515-2	2010	To investigate the mechanisms controlling the bioavailability of BDE 209, a 28-d bioaccumulation experiment was conducted in which the marine polychaete worm Nereis virens was exposed to a decabromodiphenyl ether (deca-BDE) commercial mixture (>85% BDE 209) in spiked sediments, in spiked food, or in field sediments.	decabromobiphenyl ether	189-212	homeobox D13	Homo sapiens	219-222
20821515-2	2010	To investigate the mechanisms controlling the bioavailability of BDE 209, a 28-d bioaccumulation experiment was conducted in which the marine polychaete worm Nereis virens was exposed to a decabromodiphenyl ether (deca-BDE) commercial mixture (>85% BDE 209) in spiked sediments, in spiked food, or in field sediments.	decabromobiphenyl ether	189-212	homeobox D13	Homo sapiens	219-222