PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11606774-1	2001	Homocyst(e)ine (Hcy) inhibits the expression of the antioxidant enzyme cellular glutathione peroxidase (GPx-1) in vitro and in vivo, which can lead to an increase in reactive oxygen species that inactivate NO and promote endothelial dysfunction.	(e)ine	8-14	glutathione peroxidase 1	Mus musculus	71-102
15329822-1	2004	The formation of H2S from cyst(e)ine is catalyzed by three enzymes, cystathionine beta synthase, cystathionase, and 3-mercaptopyruvate sulfurtransferase.	(e)ine	30-36	cystathionine beta-synthase	Homo sapiens	68-95
20067586-3	2010	Cystathionine beta-synthase (EC 4.2.1.22), and cystathionine gamma-lyase (CSE; EC 4.4.1.1), also known as cystathionine, can generate H(2)S from cyst(e)ine.	(e)ine	149-155	cystathionine beta-synthase	Mus musculus	0-27
20067586-3	2010	Cystathionine beta-synthase (EC 4.2.1.22), and cystathionine gamma-lyase (CSE; EC 4.4.1.1), also known as cystathionine, can generate H(2)S from cyst(e)ine.	(e)ine	149-155	cystathionase (cystathionine gamma-lyase)	Mus musculus	47-72
20067586-3	2010	Cystathionine beta-synthase (EC 4.2.1.22), and cystathionine gamma-lyase (CSE; EC 4.4.1.1), also known as cystathionine, can generate H(2)S from cyst(e)ine.	(e)ine	149-155	cystathionase (cystathionine gamma-lyase)	Mus musculus	74-77
11606774-1	2001	Homocyst(e)ine (Hcy) inhibits the expression of the antioxidant enzyme cellular glutathione peroxidase (GPx-1) in vitro and in vivo, which can lead to an increase in reactive oxygen species that inactivate NO and promote endothelial dysfunction.	(e)ine	8-14	glutathione peroxidase 1	Mus musculus	104-109
9582553-6	1998	Moreover, we found a significant inverse relationship between plasma homocyst(e)ine and folic acid concentrations in both CsA(+) (r = 0.218; p < 0.01) and CsA(-) (r = -0.678; p < 0.05) patients.	(e)ine	77-83	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	122-125
7611281-0	1995	Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.	(e)ine	52-58	tyrosinase	Homo sapiens	0-10
7611281-5	1995	We hypothesized that homocyst(e)ine inhibits tyrosinase, the major pigment enzyme.	(e)ine	29-35	tyrosinase	Homo sapiens	45-55
7611281-7	1995	Copper sulfate restored homocyst(e)ine-inhibited tyrosinase activity when added to the culture cell media at a proportion of 1.25 mol of copper sulfate per 1 mol of DL-homocysteine.	(e)ine	32-38	tyrosinase	Homo sapiens	49-59
7611281-10	1995	Our data suggest that reversible hypopigmentation in homocystinuria is the result of tyrosinase inhibition by homocyst(e)ine and that the probable mechanism of this inhibition is the interaction of homocyst(e)ine with copper at the active site of tyrosinase.	(e)ine	118-124	tyrosinase	Homo sapiens	85-95
7929609-3	1994	Amino acids L-cyst(e)ine and L-tryptophan were found to prevent serum-induced cell death of TIG-1 human fetal lung fibroblasts and other cell types.	(e)ine	18-24	retinoic acid receptor responder 1	Homo sapiens	92-97
34021002-7	2021	Therefore IL1RAP maintains cyst(e)ine and glutathione pools which are vital for redox homeostasis and anoikis resistance.	(e)ine	31-37	interleukin 1 receptor accessory protein	Homo sapiens	10-16
33707434-5	2021	Mechanistically, we find that cyst(e)ine activates mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and promotes GPX4 protein synthesis at least partly through the Rag-mTORC1-4EBP signaling axis.	(e)ine	34-40	CREB regulated transcription coactivator 1	Mus musculus	104-110
33707434-5	2021	Mechanistically, we find that cyst(e)ine activates mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and promotes GPX4 protein synthesis at least partly through the Rag-mTORC1-4EBP signaling axis.	(e)ine	34-40	glutathione peroxidase 4	Homo sapiens	125-129
33707434-5	2021	Mechanistically, we find that cyst(e)ine activates mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and promotes GPX4 protein synthesis at least partly through the Rag-mTORC1-4EBP signaling axis.	(e)ine	34-40	CREB regulated transcription coactivator 1	Mus musculus	180-186
34027051-0	2021	A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis.	(e)ine	22-28	CREB regulated transcription coactivator 1	Mus musculus	2-8
34027051-0	2021	A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis.	(e)ine	22-28	glutathione peroxidase 4	Homo sapiens	57-61