PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19865701-0	2009	Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway.	Naphthalimides	27-41	AKT serine/threonine kinase 1	Homo sapiens	90-93
20539874-1	2010	FRET cassette-type sensors, SN-1 and SN-2, which contain two naphthalimide donors and a squaraine acceptor, have been developed on the concept of switching off FRET through removing the spectral overlap by the analyte-induced decompositions of acceptor chromophore.	Naphthalimides	61-74	solute carrier family 38 member 3	Homo sapiens	28-32
20539874-1	2010	FRET cassette-type sensors, SN-1 and SN-2, which contain two naphthalimide donors and a squaraine acceptor, have been developed on the concept of switching off FRET through removing the spectral overlap by the analyte-induced decompositions of acceptor chromophore.	Naphthalimides	61-74	solute carrier family 38 member 5	Homo sapiens	37-41
20399137-2	2010	N,N-Dimetylaminoethylamino group has been used as substituent at C-4 position of the 1,8-naphthalimide chromophore structure.	Naphthalimides	85-102	complement C4A (Rodgers blood group)	Homo sapiens	65-68
19865701-0	2009	Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway.	Naphthalimides	27-41	mechanistic target of rapamycin kinase	Homo sapiens	94-98
19881958-0	2009	Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells.	Naphthalimides	0-14	ATM serine/threonine kinase	Homo sapiens	46-49
19881958-0	2009	Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells.	Naphthalimides	0-14	checkpoint kinase 2	Homo sapiens	60-64
19881958-1	2009	Naphthalimides, particularly amonafide and 2-(2-dimethylamino)-6-thia-2-aza-benzo[def]chrysene-1,3-diones (R16), have been identified to possess anticancer activities and to induce G(2)-M arrest through inhibiting topoisomerase II accompanied by Chk1 degradation.	Naphthalimides	0-14	solute carrier family 1 member 5	Homo sapiens	107-110
19881958-1	2009	Naphthalimides, particularly amonafide and 2-(2-dimethylamino)-6-thia-2-aza-benzo[def]chrysene-1,3-diones (R16), have been identified to possess anticancer activities and to induce G(2)-M arrest through inhibiting topoisomerase II accompanied by Chk1 degradation.	Naphthalimides	0-14	checkpoint kinase 1	Homo sapiens	246-250
19881958-7	2009	Moreover, the naphthalimides phosphorylated Chk2 in an ATM-dependent manner but induced Chk1 degradation.	Naphthalimides	14-28	checkpoint kinase 2	Homo sapiens	44-48
19881958-7	2009	Moreover, the naphthalimides phosphorylated Chk2 in an ATM-dependent manner but induced Chk1 degradation.	Naphthalimides	14-28	ATM serine/threonine kinase	Homo sapiens	55-58
19881958-7	2009	Moreover, the naphthalimides phosphorylated Chk2 in an ATM-dependent manner but induced Chk1 degradation.	Naphthalimides	14-28	checkpoint kinase 1	Homo sapiens	88-92
19881958-9	2009	Thus, a clear signaling pathway can be established, in which ATM relays the DNA DSBs signaling triggered by the naphthalimides to the checkpoint kinases, predominantly to Chk2,which finally elicits G(2) arrest.	Naphthalimides	112-126	ATM serine/threonine kinase	Homo sapiens	61-64
19881958-9	2009	Thus, a clear signaling pathway can be established, in which ATM relays the DNA DSBs signaling triggered by the naphthalimides to the checkpoint kinases, predominantly to Chk2,which finally elicits G(2) arrest.	Naphthalimides	112-126	checkpoint kinase 2	Homo sapiens	171-175
18646861-4	2008	Interaction of the urea receptor with anions (F (-), AcO (-), H 2PO 4 (-)) via hydrogen bonding or urea NH deprotonation resulted in significant fluorescence quenching of the 1,8-naphthalimide chromophore in an appropriately chosen model compound (ca.	Naphthalimides	175-192	kallikrein related peptidase 15	Homo sapiens	53-56
19048148-0	2008	Highly sensitive and selective Pd2+ sensor of naphthalimide derivative based on complexation with alkynes and thio-heterocycle.	Naphthalimides	46-59	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	31-34
18633498-1	2008	On the basis of fluorescent resonance energy transfer from 1,8-naphthalimide to rhodamine, a fluorophore dyad (FD8) containing rhodamine and a naphthalimide moiety was synthesized as a Cr3+-selective fluorescent probe for monitoring Cr3+ in living cells with ratiometric fluorescent methods.	Naphthalimides	59-76	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	185-188
18633498-1	2008	On the basis of fluorescent resonance energy transfer from 1,8-naphthalimide to rhodamine, a fluorophore dyad (FD8) containing rhodamine and a naphthalimide moiety was synthesized as a Cr3+-selective fluorescent probe for monitoring Cr3+ in living cells with ratiometric fluorescent methods.	Naphthalimides	63-76	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	185-188
16154757-2	2005	In this paper, the synthesis of the compound, photophysics of the newly prepared naphthalimide derivative and its interaction with model transport protein Bovine serum albumin (BSA) have been reported using the absorption and steady state fluorescence spectroscopic techniques exploiting the intrinsic fluorescence emission properties of BSA as a probe.	Naphthalimides	81-94	albumin	Homo sapiens	162-175
34739891-1	2022	An aminonaphthalimide-squaraine non-conjugated system was designed and synthetized with the purpose of preparing fluorescent molecule in the 650-700 nm region that could operate via energy transfer (ET) between covalently linked naphthalimide and squaraine chromophores.	Naphthalimides	229-242	major facilitator superfamily domain containing 11	Homo sapiens	199-201
33780070-0	2021	Intersystem Crossing and Electron Spin Selectivity in Anthracene-Naphthalimide Compact Electron Donor-Acceptor Dyads Showing Different Geometry and Electronic Coupling Magnitudes.	Naphthalimides	65-78	spindlin 1	Homo sapiens	34-38
33780070-6	2021	For the dyads showing weaker coupling between the donor and acceptors, the charge separation and the intramolecular triplet energy transfer are inhibited at 80 K (frozen solution), because both the 3 An and 3 NI states were observed and the ESP are same as compared to the native anthracene and naphthalimide, which unravel their origin.	Naphthalimides	295-308	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	241-244
34448532-0	2021	A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI.	Naphthalimides	8-21	glycoprotein VI platelet	Homo sapiens	100-104
34968849-3	2022	In this research, a novel fluorescent probe named "probe for acrolein detection" (Pr-ACR) was designed and synthesized based on a naphthalimide fluorophore skeleton, and a thiol group (-SH) was introduced into its structure for acrolein recognition.	Naphthalimides	130-143	acrosin	Homo sapiens	85-88
34119767-2	2021	NAP-MDA consists of 1,8-naphthalimide as fluorophore, morpholine and N,N-dimethylethylenediamine as pH-responsive groups.	Naphthalimides	20-37	catenin beta like 1	Homo sapiens	0-3
34528053-3	2021	Herein, two novel fluorescent probes, namely NP-C6-PCI and AM-C6-PCI, based on the conjugation of 1,8-naphthalimide with a highly selective inhibitor of HDAC8 (PCI-34051) were reported.	Naphthalimides	98-115	histone deacetylase 8	Homo sapiens	153-158
34080278-3	2021	Here we report a series of fluorescent naphthalimides, which did not originally show observable phosphorescence in solutions, as aggregates, in polymer films, or in any other tested host materials including heavy-atom matrices at cryogenic temperatures, can now efficiently produce ultralong RTP (Phi = 0.17, tau = 243 ms) in phthalimide hosts.	Naphthalimides	39-53	microtubule associated protein tau	Homo sapiens	309-312
34166768-0	2021	Suppression of oxidative phosphorylation and IDH2 sensitizes colorectal cancer to a naphthalimide derivative and mitoxantrone.	Naphthalimides	84-97	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	45-49
34161725-1	2021	A series of new naphthalimide and phenothiazine-based push-pull systems (NPI-PTZ1-5), in which we structurally modulate the oxidation state of the sulfur atom in the thiazine ring, i.e., S(II), S(IV), and S(VI), was designed and synthesized by the Pd-catalyzed Sonogashira cross-coupling reaction.	Naphthalimides	16-29	ADAM metallopeptidase with thrombospondin type 1 motif 2	Homo sapiens	73-81
34161725-1	2021	A series of new naphthalimide and phenothiazine-based push-pull systems (NPI-PTZ1-5), in which we structurally modulate the oxidation state of the sulfur atom in the thiazine ring, i.e., S(II), S(IV), and S(VI), was designed and synthesized by the Pd-catalyzed Sonogashira cross-coupling reaction.	Naphthalimides	16-29	transcription elongation factor A1	Homo sapiens	187-192
35364410-2	2022	In this work, a simple Schiff-base fluorescent probe NPP derived from naphthalimide and picolinohydrazide was rationally designed and prepared for efficient detection of Al3+.	Naphthalimides	70-83	proopiomelanocortin	Homo sapiens	53-56
34704054-7	2021	In addition, the naphthalimide tetrazine system was used for the no-wash imaging of insulin amyloid fibrils in vitro, providing a new method that can monitor their growth kinetics and morphology.	Naphthalimides	17-30	insulin	Homo sapiens	84-91
35595366-4	2022	In this study, we developed a fluorescent probe for the discriminative sensing of Cl- and Br- using a naphthalimide-benzimidazole conjugate-based Ag+ complex (L1-Ag+ complex) by exploiting the strong interaction between Ag+ and halide ions with selectivity control by pH variation.	Naphthalimides	102-115	chromosome 12 open reading frame 73	Homo sapiens	82-92
35595366-4	2022	In this study, we developed a fluorescent probe for the discriminative sensing of Cl- and Br- using a naphthalimide-benzimidazole conjugate-based Ag+ complex (L1-Ag+ complex) by exploiting the strong interaction between Ag+ and halide ions with selectivity control by pH variation.	Naphthalimides	102-115	S100 calcium binding protein A8	Homo sapiens	159-164
35286656-0	2022	Indomethacin-induced spectral responses of naphthalimide-based dyes to serum albumin: effects of substituent and spacer.	Naphthalimides	43-56	albumin	Homo sapiens	71-84
35311274-4	2022	Here, we applied molecular dynamics simulations to investigate two helix mimetics reported to have opposite effects on hIAPP aggregation in solution, the oligopyridylamide-based scaffold 1e promoted, whereas naphthalimide-appended oligopyridylamide scaffold DM 1 inhibited the aggregation of hIAPP in solution.	Naphthalimides	208-221	islet amyloid polypeptide	Homo sapiens	119-124
2621572-4	1989	The thioether of succinimide afforded a 54% reduction of serum cholesterol and a 41% reduction of serum triglyceride levels in mice after 16 d. The alkyl thioethers of 1,8-naphthalimide and succinimide significantly lowered cholesterol levels in serum VLDL and LDL, while the alkyl thioethers of succinimide elevated HDL cholesterol content.	Naphthalimides	168-185	CD320 antigen	Mus musculus	252-256
35123163-2	2022	We herein present the design, chemical synthesis, cellular imaging and biological assessment of a novel tumor-sensitive BRD4 ligand (compound 4) by introducing anticancer BRD4 inhibitor into naphthalimide moiety (fluorescent reporter) via a sulfonamide unit as glutathione (GSH)-specific cleavable linker.	Naphthalimides	191-204	bromodomain containing 4	Homo sapiens	120-124
35123163-2	2022	We herein present the design, chemical synthesis, cellular imaging and biological assessment of a novel tumor-sensitive BRD4 ligand (compound 4) by introducing anticancer BRD4 inhibitor into naphthalimide moiety (fluorescent reporter) via a sulfonamide unit as glutathione (GSH)-specific cleavable linker.	Naphthalimides	191-204	bromodomain containing 4	Homo sapiens	171-175
33904541-5	2021	The probe ER-DTT was based upon naphthalimide as a fluorophore, p-toluenesulfonamide as an exceptional unit for ER-targeting, and sulfoxide as a response site for imaging DTT based on an intramolecular charge transfer (ICT) mechanism.	Naphthalimides	32-45	epiregulin	Homo sapiens	10-12
33625414-0	2021	Luminescent naphthalimide-tagged ruthenium(II)-arene complexes: cellular imaging, photocytotoxicity and transferrin binding.	Naphthalimides	12-25	transferrin	Homo sapiens	104-115
33561716-9	2021	The wide properties for the derivatives of 1,8-naphthalimide could facilitate further in-depth mechanistic studies of WZZ02 through various fluorescent physical and chemical methods, which could help to further understand the function of PDGFR-beta gene promoter G-quadruplex and i-motif.	Naphthalimides	43-60	platelet derived growth factor receptor alpha	Homo sapiens	238-248
33759126-6	2021	Template structure used to search for novel heterocyclic and carbocyclic fragments is 1,8-naphthalimide (CAP group of scriptaid, a potent HDAC inhibitor).	Naphthalimides	86-103	histone deacetylase 9	Homo sapiens	138-142
32950500-0	2020	Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway.	Naphthalimides	34-47	tumor protein p53	Homo sapiens	25-28
32950500-0	2020	Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway.	Naphthalimides	34-47	tumor protein p53	Homo sapiens	140-143
32950500-0	2020	Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway.	Naphthalimides	34-47	epidermal growth factor receptor	Homo sapiens	144-148
32950500-3	2020	We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines.	Naphthalimides	229-242	tumor protein p53	Homo sapiens	35-38
32950500-3	2020	We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines.	Naphthalimides	229-242	tumor protein p53	Homo sapiens	108-111
32950500-3	2020	We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines.	Naphthalimides	229-242	epidermal growth factor receptor	Homo sapiens	112-116
32950500-3	2020	We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines.	Naphthalimides	229-242	epidermal growth factor receptor	Homo sapiens	118-150
32950500-3	2020	We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines.	Naphthalimides	229-242	tumor protein p53	Homo sapiens	108-111
32935360-0	2020	Comment on "Persistent Room-Temperature Radicals from Anionic Naphthalimides: Spin Pairing and Supramolecular Chemistry" and on "Persistent Radical Pairs between N-Substituted Naphthalimide and Carbanion Exhibit pKa-Dependent UV/Vis Absorption".	Naphthalimides	62-76	spindlin 1	Homo sapiens	78-82
33532593-0	2021	Effect of an alkyl spacer on the morphology and internalization of MUC1 aptamer-naphthalimide amphiphiles for targeting and imaging triple negative breast cancer cells.	Naphthalimides	80-93	mucin 1, cell surface associated	Homo sapiens	67-71
32276227-1	2020	A novel hydroxy functionalized naphthalimide-based fluorescent probe (denoted SP2)was successfully designed and synthesized for monitoring of H2S in living cells and environmental.	Naphthalimides	31-44	Sp2 transcription factor	Homo sapiens	78-81
32668630-1	2020	Three new 1,8-naphthalimide derivatives M1-M3 with different substituents at the C-4 position have been synthesized and characterized.	Naphthalimides	10-27	complement C4A (Rodgers blood group)	Homo sapiens	81-84
32270586-1	2020	We prepared conceptually novel, fully rigid, spiro compact electron donor (Rhodamine B, lactam form)/acceptor (naphthalimide) orthogonal dyad to attain the long-lived triplet charge transfer (3CT) state, based on the electron spin control using spin-orbit charge transfer intersystem crossing (SOCT-ISC).	Naphthalimides	111-124	spindlin 1	Homo sapiens	226-230
32270586-1	2020	We prepared conceptually novel, fully rigid, spiro compact electron donor (Rhodamine B, lactam form)/acceptor (naphthalimide) orthogonal dyad to attain the long-lived triplet charge transfer (3CT) state, based on the electron spin control using spin-orbit charge transfer intersystem crossing (SOCT-ISC).	Naphthalimides	111-124	spindlin 1	Homo sapiens	245-249
32270586-6	2020	With time-resolved electron paramagnetic resonance (TREPR) spectra, an EEEAAA electron-spin polarization pattern was observed for the naphthalimide-localized triplet state.	Naphthalimides	134-147	spindlin 1	Homo sapiens	87-91
32245186-6	2020	MT-1 was constructed by integrating the naphthalimide moiety (donor) and rhodamine B (accepter and targeting group) through a newly designed linker.	Naphthalimides	40-53	metallothionein 1I, pseudogene	Homo sapiens	0-4
32037409-4	2020	NVP-AUY922 is a heat shock protein 90 (HSP90) inhibitor with preferential tumor selectivity that is conjugated to 4-hydroxy-1,8-naphthalimide as a tumor-targeting ligand.	Naphthalimides	114-141	heat shock protein 90 alpha family class A member 1	Homo sapiens	16-37
32037409-4	2020	NVP-AUY922 is a heat shock protein 90 (HSP90) inhibitor with preferential tumor selectivity that is conjugated to 4-hydroxy-1,8-naphthalimide as a tumor-targeting ligand.	Naphthalimides	114-141	heat shock protein 90 alpha family class A member 1	Homo sapiens	39-44
31861836-0	2019	Cancer-Specific hNQO1-Responsive Biocompatible Naphthalimides Providing a Rapid Fluorescent Turn-On with an Enhanced Enzyme Affinity.	Naphthalimides	47-61	NAD(P)H quinone dehydrogenase 1	Homo sapiens	16-21
31844857-1	2020	A series of six different 1,8-naphthalimide conjugated dipicolylamine ligands (L1-6) have been synthesised and characterised.	Naphthalimides	28-43	immunoglobulin kappa variable 3D-15	Homo sapiens	79-83
31892069-2	2020	L-pH is composed of three moieties, including naphthalimide fluorophore as a fluorescence off-on response moiety, piperazine and morpholine groups as lysosomal targeting and pH responsive sites, as well as a reactive benzyl chloride segment for further lysosomal anchoring.	Naphthalimides	46-59	lactase	Mus musculus	0-4
31861836-3	2019	Herein, we report naphthalimide-based fluorescent probes 1 and 2 that can detect hNQO1.	Naphthalimides	18-31	NAD(P)H quinone dehydrogenase 1	Homo sapiens	81-86
31343787-0	2019	Persistent Room-Temperature Radicals from Anionic Naphthalimides: Spin Pairing and Supramolecular Chemistry.	Naphthalimides	50-64	spindlin 1	Homo sapiens	66-70
31490511-5	2019	Each of the three technetium-99m labelled naphthalimide complexes were successfully produced from fac-[99mTc(CO)3(H2O)3]+ in 15 minutes at 70  C and isolated in radiochemical yields ranging from 60-95% with radiochemical purities greater than 95%.	Naphthalimides	42-55	FA complementation group C	Homo sapiens	98-101
31670325-0	2019	A highly selective ratiometric fluorescent probe based on naphthalimide for detection and imaging of CYP1A1 in living cells and zebrafish.	Naphthalimides	58-71	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	101-107
31670325-2	2019	Herein, according to slight differences in the 3D structure and substrate preference between CYP1A1 and its homologous CYP1A2, a series of novel ratiometric fluorescent probes were designed and synthesized using 1,8-naphthalimide because of its trait of naked-eye visualization and ratiometric fluorescence to achieve the detection of CYP1A1 in biological samples.	Naphthalimides	212-229	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
31670325-2	2019	Herein, according to slight differences in the 3D structure and substrate preference between CYP1A1 and its homologous CYP1A2, a series of novel ratiometric fluorescent probes were designed and synthesized using 1,8-naphthalimide because of its trait of naked-eye visualization and ratiometric fluorescence to achieve the detection of CYP1A1 in biological samples.	Naphthalimides	212-229	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	119-125
31670325-2	2019	Herein, according to slight differences in the 3D structure and substrate preference between CYP1A1 and its homologous CYP1A2, a series of novel ratiometric fluorescent probes were designed and synthesized using 1,8-naphthalimide because of its trait of naked-eye visualization and ratiometric fluorescence to achieve the detection of CYP1A1 in biological samples.	Naphthalimides	212-229	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	335-341
30995142-0	2019	UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway.	Naphthalimides	20-33	AKT serine/threonine kinase 1	Homo sapiens	103-106
30995142-0	2019	UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway.	Naphthalimides	20-33	mitogen-activated protein kinase 1	Homo sapiens	107-110
30544880-0	2018	A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway.	Naphthalimides	58-71	mitogen-activated protein kinase 14	Homo sapiens	148-151
30629076-0	2019	Glycosylated naphthalimides and naphthalimide Troger"s bases as fluorescent aggregation probes for Con A. Herein we report the synthesis of fluorescent, glycosylated 4-amino-1,8-naphthalimide (Nap) 1, and the related 1,8-naphthalimides Troger"s bases (TBNap) 2 and 3, from 1,8-naphthalic anhydride precursors, the alpha-mannosides being introduced through the use of CuAAC mediated "click" chemistry.	Naphthalimides	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	166-199
31036214-0	2019	A novel dithiourea-appended naphthalimide "on-off" fluorescent probe for detecting Hg2+ and Ag+ and its application in cell imaging.	Naphthalimides	28-41	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	83-86
31143885-1	2019	A naphthalimide-aminal-based fluorescent donor (NAP-FAD-1) is a pH-sensitive smart donor, which features accelerated FA release at pH 5.0 compared to that at pH 7.4 and fluorescence turn-on readout for facile tracking and quantification of FA release.	Naphthalimides	2-15	flavin adenine dinucleotide synthetase 1	Homo sapiens	52-57
30892331-0	2019	Insight into the delivery channel and selectivity of multiple binding sites in bovine serum albumin towards naphthalimide-polyamine derivatives.	Naphthalimides	108-121	albumin	Homo sapiens	86-99
30892331-3	2019	Herein, the delivery and binding of the naphthalimide-polyamine complex assisted by the bovine serum albumin (BSA) protein have been studied by combining several molecular dynamic simulations.	Naphthalimides	40-53	albumin	Homo sapiens	95-122
30597284-1	2019	We have developed a FRET-based fluorescent probe (PHS1) as a combination of two different fluorophores (coumarin and naphthalimide); which can detect both exogenous and endogenous H2S and H2O2 in live cells through multicolor images.	Naphthalimides	117-130	prostaglandin-endoperoxide synthase 1	Homo sapiens	50-54
30597284-2	2019	The precise overlap between UV-absorption of naphthalimide and the emission band of coumarin in probe PHS1 allows the acquisition of the self-calibrated information of dual analytes through FRET-based imaging.	Naphthalimides	45-58	prostaglandin-endoperoxide synthase 1	Homo sapiens	102-106
30544880-4	2018	Further analyses revealed a rapid and consistent activation of p38 signaling by the naphthalimide-NHC conjugates, with the Ru(II) analogue-termed MC6-showing the strongest effect.	Naphthalimides	84-97	mitogen-activated protein kinase 14	Homo sapiens	63-66
30544880-7	2018	Altogether, our results provide new insight into the molecular mechanisms of naphthalimide-metal NHC analogues via the ROS-induced activation of p38 MAPK, which may have therapeutic interest for the treatment of various cancer types.	Naphthalimides	77-90	mitogen-activated protein kinase 14	Homo sapiens	145-148
29796828-0	2018	A Multi-Responsive Naphthalimide-Based "Turn-on" Fluorescent Chemosensor for Sensitive Detection of Trivalent Cations Ga3+, Al3+ and Cr3.	Naphthalimides	19-32	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	133-136
30168823-4	2018	Herein, a series of fluorescent HDAC6-selective inhibitors incorporating a naphthalimide skeleton were designed and synthesized.	Naphthalimides	75-88	histone deacetylase 6	Homo sapiens	32-37
29698606-4	2018	The intramolecular charge transfer (ICT) interactions in the resulting BN-fused naphthalimides (BN0-BN3) together with their precursors (N0-N3) and fluoride-coordinated analogues (FBN0-FBN3) have been systematically investigated by photophysical, electrochemical, and theoretical approaches.	Naphthalimides	80-94	fibrillin 3	Homo sapiens	185-189
29390898-2	2018	Based on the catalytic mechanism and structure of the catalytic domains of these beta-N-acetylhexosaminidases, a series of novel naphthalimide moiety-bearing thioglycosides with different flexible linkers were designed, and their inhibitory potency against hsHexB and hOGA was evaluated.	Naphthalimides	129-142	O-GlcNAcase	Homo sapiens	268-272
30156587-0	2018	A highly selective naphthalimide-based ratiometric fluorescent probe for the recognition of tyrosinase and cellular imaging.	Naphthalimides	19-32	tyrosinase	Homo sapiens	92-102
30156587-2	2018	Therefore, for the recognition of tyrosinase, naphthalimide-based ratiometric fluorescent sensor probe was designed and synthesized.	Naphthalimides	46-59	tyrosinase	Homo sapiens	34-44
28849853-0	2017	A novel supramolecular polymer gel based on naphthalimide functionalized-pillar[5]arene for the fluorescence detection of Hg2+ and I- and recyclable removal of Hg2+via cation-pi interactions.	Naphthalimides	44-57	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	122-125
29316508-0	2018	Synthesis and biological evaluation of naphthalimide-polyamine conjugates modified by alkylation as anticancer agents through p53 pathway.	Naphthalimides	39-52	tumor protein p53	Homo sapiens	126-129
29375976-4	2018	One building block (cholesterol conjugated cynanostilbene, CCS) consists of cholesterol conjugated with a cynanostilbene unit, and the other one (C10CN) is comprised of cholesterol connected with a naphthalimide group having a flexible long alkyl chain.	Naphthalimides	198-211	copper chaperone for superoxide dismutase	Homo sapiens	59-62
29072615-8	2017	Collectively, our data show that LSS-11 is a potent naphthalimide-based chemosensitizer that could enhance cell death in paclitaxel-resistant lung cancer cells through the DR5/PARP1 pathway and STAT3/MDR1/MRP1 STAT3 inhibition.	Naphthalimides	52-65	TNF receptor superfamily member 10b	Homo sapiens	172-175
29072615-8	2017	Collectively, our data show that LSS-11 is a potent naphthalimide-based chemosensitizer that could enhance cell death in paclitaxel-resistant lung cancer cells through the DR5/PARP1 pathway and STAT3/MDR1/MRP1 STAT3 inhibition.	Naphthalimides	52-65	signal transducer and activator of transcription 3	Homo sapiens	194-199
28849853-0	2017	A novel supramolecular polymer gel based on naphthalimide functionalized-pillar[5]arene for the fluorescence detection of Hg2+ and I- and recyclable removal of Hg2+via cation-pi interactions.	Naphthalimides	44-57	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	160-163
28675031-7	2017	In the proposed design, a donor-pi-acceptor (D-pi-A) structured naphthalimide derivative with efficient two-photon properties was chosen as the fluorescent group, and a 2,4-dinitrobenzenesulfonate group was employed as the GST recognition unit, which also acted as the fluorescence quencher.	Naphthalimides	64-77	glutathione S-transferase kappa 1	Homo sapiens	223-226
28343244-0	2017	A New Reactive 1,8-Naphthalimide Derivative for Highly Selective and Sensitive Detection of Hg2.	Naphthalimides	15-32	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	92-95
28737377-0	2017	Carbon Dot Based, Naphthalimide Coupled FRET Pair for Highly Selective Ratiometric Detection of Thioredoxin Reductase and Cancer Screening.	Naphthalimides	18-31	peroxiredoxin 5	Homo sapiens	96-117
28737377-1	2017	The fluorescence resonance energy transfer (FRET) mechanism has been established between carbon dots (CDs) and naphthalimide to monitor the activity of thioredoxin reductase (TrxR), which is often overexpressed in many cancer cells.	Naphthalimides	111-124	peroxiredoxin 5	Homo sapiens	152-173
28737377-1	2017	The fluorescence resonance energy transfer (FRET) mechanism has been established between carbon dots (CDs) and naphthalimide to monitor the activity of thioredoxin reductase (TrxR), which is often overexpressed in many cancer cells.	Naphthalimides	111-124	peroxiredoxin 5	Homo sapiens	175-179
28737377-4	2017	However, contrary to this, the elevated levels of TrxR cause the breakage of disulfide bonds and consequently abolishes the FRET pair through the release of the naphthalimide moiety from the surface of CDs.	Naphthalimides	161-174	peroxiredoxin 5	Homo sapiens	50-54
28524357-4	2017	For the construction of antibody-probe conjugates from an anti-carcinoembryonic antigen and a quinone-caged profluorescent naphthalimide derivative, the dual "click" coupling process with C1 was monitored on the basis of the emission turn-on of C1, whereas prominent changes in FRET ratios occurred for antibody-imaging-probe conjugates when specifically triggered by quinone oxidoreductase (NQO1), which is overexpressed in various types of cancer cells.	Naphthalimides	123-136	crystallin zeta	Homo sapiens	368-390
28524357-4	2017	For the construction of antibody-probe conjugates from an anti-carcinoembryonic antigen and a quinone-caged profluorescent naphthalimide derivative, the dual "click" coupling process with C1 was monitored on the basis of the emission turn-on of C1, whereas prominent changes in FRET ratios occurred for antibody-imaging-probe conjugates when specifically triggered by quinone oxidoreductase (NQO1), which is overexpressed in various types of cancer cells.	Naphthalimides	123-136	NAD(P)H quinone dehydrogenase 1	Homo sapiens	392-396
28527428-5	2017	Due to their unique optical properties and their many uses in different areas such as supramolecular chemistry or biomedicine, we have chosen a derivative from the family of naphthalimides (the 4-amino-1,8-naphthalimide-N-substituted; ANN) to study the interaction with different CNPs (CNP1-4) and their joint bioactivity compared to that of the same compounds alone.	Naphthalimides	174-188	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	286-292
27997743-0	2017	Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents.	Naphthalimides	25-38	high mobility group nucleosomal binding domain 4	Homo sapiens	6-9
28110683-3	2017	By contrast, probes 2 and 3 possessing 1,8-naphthalimide and pyrene fluorophores, respectively, exhibited selective fluorescent "OFF-ON" behaviors as a result of Ga3+/Al3+ binding among the diverse metal ions, suggesting the importance of fluorophore electronic character with regard to metal ion sensing.	Naphthalimides	39-56	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	162-165
28451319-1	2017	Donor-acceptor-acceptor (D-A-A) type 1,8-naphthalimide based small molecules SM1 and SM2 functionalized with tetracyanobutadiene (TCBD) and dicyanoquino-dimethane (DCNQ) modules, showing strong absorption in the visible and near-infrared (NIR) region are reported.	Naphthalimides	37-54	SM1	Homo sapiens	77-80
28451319-1	2017	Donor-acceptor-acceptor (D-A-A) type 1,8-naphthalimide based small molecules SM1 and SM2 functionalized with tetracyanobutadiene (TCBD) and dicyanoquino-dimethane (DCNQ) modules, showing strong absorption in the visible and near-infrared (NIR) region are reported.	Naphthalimides	37-54	SM2	Homo sapiens	85-88
27626909-4	2016	NADE used 1,8-naphthalimide as the signal reporter and adenosine (Ade) as the reaction center; removal of the Ade moiety enhanced the fluorescence by >10-fold.	Naphthalimides	10-27	brain expressed X-linked 3	Homo sapiens	0-4
26668309-0	2016	A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak Bcl-xl Complex and Triggering Transcriptional Regulation.	Naphthalimides	8-21	tumor protein p53	Homo sapiens	40-43
26816264-0	2016	Design, Synthesis, and Proticity Inclined Conformational Modulation in a Highly Fluorescent Bichromophoric Naphthalimide Derivative: Hint Directed from RICT Perspective.	Naphthalimides	107-120	histidine triad nucleotide binding protein 1	Homo sapiens	133-137
27651806-5	2016	Hence, in this research, we focused on the synthesis of naphthalimide analogs as potential 15-LOX-1 inhibitors.	Naphthalimides	56-69	arachidonate 15-lipoxygenase	Homo sapiens	91-99
27651806-7	2016	Naphthalimide derivatives could be suggested as potential LOX inhibitors with likely applications of anticancer activity.	Naphthalimides	0-13	lysyl oxidase	Homo sapiens	58-61
26845638-1	2016	Four small molecular acceptors (SM1-4) comprising a central benzene core, two thiophene bridges and two 1,8-naphthalimide (NI) terminal groups were designed and synthesized by direct C-H activation.	Naphthalimides	104-121	SM1	Homo sapiens	32-37
26668309-0	2016	A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak Bcl-xl Complex and Triggering Transcriptional Regulation.	Naphthalimides	8-21	BCL2 antagonist/killer 1	Homo sapiens	103-106
26668309-0	2016	A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak Bcl-xl Complex and Triggering Transcriptional Regulation.	Naphthalimides	8-21	BCL2 like 1	Homo sapiens	107-113
26668309-8	2016	This work provided new insights into the molecular interactions and anticancer mechanisms of phospho-p53-dependent naphthalimide compounds.	Naphthalimides	115-128	tumor protein p53	Homo sapiens	101-104
25730340-0	2015	Sensitization of cisplatin therapy by a naphthalimide based organoselenium compound through modulation of antioxidant enzymes and p53 mediated apoptosis.	Naphthalimides	40-53	transformation related protein 53, pseudogene	Mus musculus	130-133
25991384-0	2016	Investigations on the interactions between naphthalimide-based anti-tumor drugs and human serum albumin by spectroscopic and molecular modeling methods.	Naphthalimides	43-56	albumin	Homo sapiens	90-103
25991384-1	2016	The interactions between the three kinds of naphthalimide-based anti-tumor drugs (NADA, NADB, NADC) and human serum albumin (HSA) under simulated physiological conditions were investigated by fluorescence spectroscopy, circular dichroism spectroscopy and molecular modeling.	Naphthalimides	44-57	albumin	Homo sapiens	110-123
26378511-0	2015	Spectroscopic Study on the Interaction between Naphthalimide-Polyamine Conjugates and Bovine Serum Albumin (BSA).	Naphthalimides	47-60	albumin	Homo sapiens	93-106
26378511-1	2015	The effect of a naphthalimide pharmacophore coupled with diverse substituents on the interaction between naphthalimide-polyamine conjugates 1-4 and bovine serum albumin (BSA) was studied by UV absorption, fluorescence and circular dichroism (CD) spectroscopy under physiological conditions (pH = 7.4).	Naphthalimides	16-29	albumin	Homo sapiens	155-168
26378511-1	2015	The effect of a naphthalimide pharmacophore coupled with diverse substituents on the interaction between naphthalimide-polyamine conjugates 1-4 and bovine serum albumin (BSA) was studied by UV absorption, fluorescence and circular dichroism (CD) spectroscopy under physiological conditions (pH = 7.4).	Naphthalimides	105-118	albumin	Homo sapiens	155-168
32261982-4	2015	The presence of ALP cleaves the phosphate group from naphthalimide and remarkably alters the probe"s photophysical properties, thus achieving ratiometric detection of ALP.	Naphthalimides	53-66	alkaline phosphatase, placental	Homo sapiens	16-19
32261982-4	2015	The presence of ALP cleaves the phosphate group from naphthalimide and remarkably alters the probe"s photophysical properties, thus achieving ratiometric detection of ALP.	Naphthalimides	53-66	alkaline phosphatase, placental	Homo sapiens	167-170
24919009-3	2014	A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was investigated as a Cu(2+) selective fluorescent sensor in living cells.	Naphthalimides	8-21	natriuretic peptide B	Homo sapiens	67-70
24803348-0	2014	Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators.	Naphthalimides	46-59	peroxiredoxin 5	Homo sapiens	80-101
25196578-3	2014	Here, we developed a highly sensitive and versatile ratiometric H2O2 fluorescent probe (NP1) based on 1,8-naphthalimide and boric acid ester.	Naphthalimides	102-119	neuronal pentraxin 1	Homo sapiens	88-91
24803348-2	2014	The complexes were potent DNA intercalators related to their naphthalimide partial structure, inhibited TrxR as a consequence of the incorporation of the gold(I) moiety, and triggered efficient cytotoxic effects in MCF-7 breast and HT-29 colon adenocarcinoma cells.	Naphthalimides	61-74	peroxiredoxin 5	Homo sapiens	104-108
23174889-1	2013	In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed and synthesized, which can be recognized and hydrolyzed by aminopeptidase N (APN) at both the enzymatic and cellular level by following the fluorescent emission wavelength change from blue to green light.	Naphthalimides	102-115	alanyl aminopeptidase, membrane	Homo sapiens	206-222
24723120-0	2014	A naphthalimide-based bifunctional fluorescent probe for the differential detection of Hg2+ and Cu2+ in aqueous solution.	Naphthalimides	2-15	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	87-90
24723120-1	2014	A novel fluorescent probe NPM based on naphthalimide was designed and synthesized.	Naphthalimides	39-52	nucleophosmin 1	Homo sapiens	26-29
24351040-3	2014	TRFS-green displays a green fluorescence off-on change induced by the TrxR-mediated disulfide cleavage and subsequent intramolecular cyclization to liberate the masked naphthalimide fluorophore.	Naphthalimides	168-181	peroxiredoxin 5	Homo sapiens	70-74
24351040-5	2014	HPLC analyses indicated that TRFS-green was exclusively converted to naphthalimide catalyzed by TrxR.	Naphthalimides	69-82	peroxiredoxin 5	Homo sapiens	96-100
23810913-3	2013	The newly designed probe 1 contains a propargylamine moiety at C-4 of the naphthalimide chromophore that reacts with Au(3+) to generate a product that has distinctly different electronic properties from 1.	Naphthalimides	74-87	complement C4A (Rodgers blood group)	Homo sapiens	63-66
24013474-1	2013	We demonstrate that replacing the hydrazone linkage by a linear pi-spacer bridging a carbazole donor and a naphthalimide acceptor induces a critical change in molecular organization and electron density distribution in the conjugation backbone that correlates with a remarkable variation of memory performance from DRAM to WORM types.	Naphthalimides	107-120	DNA damage regulated autophagy modulator 1	Homo sapiens	315-319
23810444-0	2013	7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-kappaB in LPS-stimulated RAW264.7 macrophages.	Naphthalimides	12-25	mitogen-activated protein kinase kinase kinase 7	Mus musculus	98-102
23810444-0	2013	7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-kappaB in LPS-stimulated RAW264.7 macrophages.	Naphthalimides	12-25	mitogen-activated protein kinase 3	Mus musculus	132-138
23810444-0	2013	7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-kappaB in LPS-stimulated RAW264.7 macrophages.	Naphthalimides	12-25	mitogen-activated protein kinase 14	Mus musculus	144-147
23810444-0	2013	7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-kappaB in LPS-stimulated RAW264.7 macrophages.	Naphthalimides	12-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	176-185
23994328-1	2013	A series of amine substituted naphthalimide analogue were synthesized and evaluated for in vitro anti-tumour activities against 60 tumour cell lines at a single dose concentration of 10 muM.	Naphthalimides	30-43	latexin	Homo sapiens	186-189
23165407-0	2013	Simple naphthalimide-based fluorescent sensor for highly sensitive and selective detection of Cd2+ and Cu2+ in aqueous solution and living cells.	Naphthalimides	7-20	CD2 molecule	Homo sapiens	94-97
23174889-1	2013	In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed and synthesized, which can be recognized and hydrolyzed by aminopeptidase N (APN) at both the enzymatic and cellular level by following the fluorescent emission wavelength change from blue to green light.	Naphthalimides	102-115	alanyl aminopeptidase, membrane	Homo sapiens	224-227
21821060-3	2011	Treatment with naphthalimide-based DNA intercalators, including M2-A and R16, generally leads to a decrease in Bcl-2 intracellular amounts.	Naphthalimides	15-28	BCL2 apoptosis regulator	Homo sapiens	111-116
22932925-0	2012	FRET-based ratiometric detection of Hg2+ and biothiols using naphthalimide-rhodamine dyads.	Naphthalimides	61-74	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	36-39
22026405-1	2011	Two novel photochromic naphthopyrans containing naphthalimide moieties (Nip1 and Nip2) were studied in solution under flash photolysis conditions, exhibiting highly photochromic response, rapid thermal bleaching rate and good fatigue-resistance.	Naphthalimides	48-61	BCL2 interacting protein 1	Homo sapiens	72-76
22026405-1	2011	Two novel photochromic naphthopyrans containing naphthalimide moieties (Nip1 and Nip2) were studied in solution under flash photolysis conditions, exhibiting highly photochromic response, rapid thermal bleaching rate and good fatigue-resistance.	Naphthalimides	48-61	BCL2 interacting protein 2	Homo sapiens	81-85
22026405-2	2011	Owing to the different N-substituted imide groups at the naphthalimide units, the thermal bleaching rate of Nip2 bearing phenyl on the naphthalimide unit is found to be approximately 2 times that of Nip1 bearing n-butyl, indicating that the photochromic properties can be modulated with introduction of different functional groups on the naphthalimide unit.	Naphthalimides	57-70	BCL2 interacting protein 2	Homo sapiens	108-112
22026405-2	2011	Owing to the different N-substituted imide groups at the naphthalimide units, the thermal bleaching rate of Nip2 bearing phenyl on the naphthalimide unit is found to be approximately 2 times that of Nip1 bearing n-butyl, indicating that the photochromic properties can be modulated with introduction of different functional groups on the naphthalimide unit.	Naphthalimides	135-148	BCL2 interacting protein 2	Homo sapiens	108-112
22026405-2	2011	Owing to the different N-substituted imide groups at the naphthalimide units, the thermal bleaching rate of Nip2 bearing phenyl on the naphthalimide unit is found to be approximately 2 times that of Nip1 bearing n-butyl, indicating that the photochromic properties can be modulated with introduction of different functional groups on the naphthalimide unit.	Naphthalimides	135-148	BCL2 interacting protein 2	Homo sapiens	108-112
22026405-3	2011	In Nip1 and Nip2, the strong electron-withdrawing effect of the imide group incorporated at the naphthalimide moiety maintains several merits: (i) shifting absorption bands to longer wavelength, (ii) beneficial to an enhancement in the ratio of transoid-cis (TC) isomer and an increase in the transformation rate from transoid-trans (TT) to TC with respect to reference compound NP, and (iii) resulting in a preferable color bleaching rate and fading absolutely to their colorless state with thermal reversibility.	Naphthalimides	96-109	BCL2 interacting protein 1	Homo sapiens	3-7
22026405-3	2011	In Nip1 and Nip2, the strong electron-withdrawing effect of the imide group incorporated at the naphthalimide moiety maintains several merits: (i) shifting absorption bands to longer wavelength, (ii) beneficial to an enhancement in the ratio of transoid-cis (TC) isomer and an increase in the transformation rate from transoid-trans (TT) to TC with respect to reference compound NP, and (iii) resulting in a preferable color bleaching rate and fading absolutely to their colorless state with thermal reversibility.	Naphthalimides	96-109	BCL2 interacting protein 2	Homo sapiens	12-16
21821060-5	2011	We report here that p53 contributes to Bcl-2 down-regulation induced by B1, a novel naphthalimide-based DNA intercalating agent.	Naphthalimides	84-97	tumor protein p53	Homo sapiens	20-23
21821060-5	2011	We report here that p53 contributes to Bcl-2 down-regulation induced by B1, a novel naphthalimide-based DNA intercalating agent.	Naphthalimides	84-97	BCL2 apoptosis regulator	Homo sapiens	39-44
21821060-10	2011	Our study strengthens the links between p53 and Bcl-2 at a transcriptional level, upon naphthalimide-based DNA intercalator treatment.	Naphthalimides	87-100	tumor protein p53	Homo sapiens	40-43
21821060-10	2011	Our study strengthens the links between p53 and Bcl-2 at a transcriptional level, upon naphthalimide-based DNA intercalator treatment.	Naphthalimides	87-100	BCL2 apoptosis regulator	Homo sapiens	48-53
21909097-5	2011	The antiviral activity of naphthalimides was abolished in REDD1(-/-) cells.	Naphthalimides	26-40	DNA damage inducible transcript 4	Homo sapiens	58-63
21807232-1	2011	A novel Cu(2+)-specific "off-on" fluorescent chemosensor of naphthalimide modified rhodamine B (naphthalimide modified rhodamine B chemosensor, NRC) was designed and synthesized, based on the equilibrium between the spirolactam (non-fluorescence) and the ring-opened amide (fluorescence).	Naphthalimides	60-73	nuclear receptor coactivator 6	Homo sapiens	144-147
21807232-1	2011	A novel Cu(2+)-specific "off-on" fluorescent chemosensor of naphthalimide modified rhodamine B (naphthalimide modified rhodamine B chemosensor, NRC) was designed and synthesized, based on the equilibrium between the spirolactam (non-fluorescence) and the ring-opened amide (fluorescence).	Naphthalimides	96-109	nuclear receptor coactivator 6	Homo sapiens	144-147
20179988-0	2011	B1, a novel naphthalimide-based DNA intercalator, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation.	Naphthalimides	12-25	tumor protein p53	Homo sapiens	108-111