PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34739891-1 2022 An aminonaphthalimide-squaraine non-conjugated system was designed and synthetized with the purpose of preparing fluorescent molecule in the 650-700 nm region that could operate via energy transfer (ET) between covalently linked naphthalimide and squaraine chromophores. Naphthalimides 229-242 major facilitator superfamily domain containing 11 Homo sapiens 199-201 34968849-3 2022 In this research, a novel fluorescent probe named "probe for acrolein detection" (Pr-ACR) was designed and synthesized based on a naphthalimide fluorophore skeleton, and a thiol group (-SH) was introduced into its structure for acrolein recognition. Naphthalimides 130-143 acrosin Homo sapiens 85-88 33780070-0 2021 Intersystem Crossing and Electron Spin Selectivity in Anthracene-Naphthalimide Compact Electron Donor-Acceptor Dyads Showing Different Geometry and Electronic Coupling Magnitudes. Naphthalimides 65-78 spindlin 1 Homo sapiens 34-38 33780070-6 2021 For the dyads showing weaker coupling between the donor and acceptors, the charge separation and the intramolecular triplet energy transfer are inhibited at 80 K (frozen solution), because both the 3 An and 3 NI states were observed and the ESP are same as compared to the native anthracene and naphthalimide, which unravel their origin. Naphthalimides 295-308 protein tyrosine phosphatase receptor type V, pseudogene Homo sapiens 241-244 34704054-7 2021 In addition, the naphthalimide tetrazine system was used for the no-wash imaging of insulin amyloid fibrils in vitro, providing a new method that can monitor their growth kinetics and morphology. Naphthalimides 17-30 insulin Homo sapiens 84-91 34119767-2 2021 NAP-MDA consists of 1,8-naphthalimide as fluorophore, morpholine and N,N-dimethylethylenediamine as pH-responsive groups. Naphthalimides 20-37 catenin beta like 1 Homo sapiens 0-3 34166768-0 2021 Suppression of oxidative phosphorylation and IDH2 sensitizes colorectal cancer to a naphthalimide derivative and mitoxantrone. Naphthalimides 84-97 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 45-49 34528053-3 2021 Herein, two novel fluorescent probes, namely NP-C6-PCI and AM-C6-PCI, based on the conjugation of 1,8-naphthalimide with a highly selective inhibitor of HDAC8 (PCI-34051) were reported. Naphthalimides 98-115 histone deacetylase 8 Homo sapiens 153-158 34448532-0 2021 A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI. Naphthalimides 8-21 glycoprotein VI platelet Homo sapiens 100-104 34080278-3 2021 Here we report a series of fluorescent naphthalimides, which did not originally show observable phosphorescence in solutions, as aggregates, in polymer films, or in any other tested host materials including heavy-atom matrices at cryogenic temperatures, can now efficiently produce ultralong RTP (Phi = 0.17, tau = 243 ms) in phthalimide hosts. Naphthalimides 39-53 microtubule associated protein tau Homo sapiens 309-312 2621572-4 1989 The thioether of succinimide afforded a 54% reduction of serum cholesterol and a 41% reduction of serum triglyceride levels in mice after 16 d. The alkyl thioethers of 1,8-naphthalimide and succinimide significantly lowered cholesterol levels in serum VLDL and LDL, while the alkyl thioethers of succinimide elevated HDL cholesterol content. Naphthalimides 168-185 CD320 antigen Mus musculus 252-256 35595366-4 2022 In this study, we developed a fluorescent probe for the discriminative sensing of Cl- and Br- using a naphthalimide-benzimidazole conjugate-based Ag+ complex (L1-Ag+ complex) by exploiting the strong interaction between Ag+ and halide ions with selectivity control by pH variation. Naphthalimides 102-115 chromosome 12 open reading frame 73 Homo sapiens 82-92 35595366-4 2022 In this study, we developed a fluorescent probe for the discriminative sensing of Cl- and Br- using a naphthalimide-benzimidazole conjugate-based Ag+ complex (L1-Ag+ complex) by exploiting the strong interaction between Ag+ and halide ions with selectivity control by pH variation. Naphthalimides 102-115 S100 calcium binding protein A8 Homo sapiens 159-164 35123163-2 2022 We herein present the design, chemical synthesis, cellular imaging and biological assessment of a novel tumor-sensitive BRD4 ligand (compound 4) by introducing anticancer BRD4 inhibitor into naphthalimide moiety (fluorescent reporter) via a sulfonamide unit as glutathione (GSH)-specific cleavable linker. Naphthalimides 191-204 bromodomain containing 4 Homo sapiens 120-124 35123163-2 2022 We herein present the design, chemical synthesis, cellular imaging and biological assessment of a novel tumor-sensitive BRD4 ligand (compound 4) by introducing anticancer BRD4 inhibitor into naphthalimide moiety (fluorescent reporter) via a sulfonamide unit as glutathione (GSH)-specific cleavable linker. Naphthalimides 191-204 bromodomain containing 4 Homo sapiens 171-175 34161725-1 2021 A series of new naphthalimide and phenothiazine-based push-pull systems (NPI-PTZ1-5), in which we structurally modulate the oxidation state of the sulfur atom in the thiazine ring, i.e., S(II), S(IV), and S(VI), was designed and synthesized by the Pd-catalyzed Sonogashira cross-coupling reaction. Naphthalimides 16-29 ADAM metallopeptidase with thrombospondin type 1 motif 2 Homo sapiens 73-81 34161725-1 2021 A series of new naphthalimide and phenothiazine-based push-pull systems (NPI-PTZ1-5), in which we structurally modulate the oxidation state of the sulfur atom in the thiazine ring, i.e., S(II), S(IV), and S(VI), was designed and synthesized by the Pd-catalyzed Sonogashira cross-coupling reaction. Naphthalimides 16-29 transcription elongation factor A1 Homo sapiens 187-192 35364410-2 2022 In this work, a simple Schiff-base fluorescent probe NPP derived from naphthalimide and picolinohydrazide was rationally designed and prepared for efficient detection of Al3+. Naphthalimides 70-83 proopiomelanocortin Homo sapiens 53-56 35311274-4 2022 Here, we applied molecular dynamics simulations to investigate two helix mimetics reported to have opposite effects on hIAPP aggregation in solution, the oligopyridylamide-based scaffold 1e promoted, whereas naphthalimide-appended oligopyridylamide scaffold DM 1 inhibited the aggregation of hIAPP in solution. Naphthalimides 208-221 islet amyloid polypeptide Homo sapiens 119-124 35286656-0 2022 Indomethacin-induced spectral responses of naphthalimide-based dyes to serum albumin: effects of substituent and spacer. Naphthalimides 43-56 albumin Homo sapiens 71-84 32935360-0 2020 Comment on "Persistent Room-Temperature Radicals from Anionic Naphthalimides: Spin Pairing and Supramolecular Chemistry" and on "Persistent Radical Pairs between N-Substituted Naphthalimide and Carbanion Exhibit pKa-Dependent UV/Vis Absorption". Naphthalimides 62-76 spindlin 1 Homo sapiens 78-82 33561716-9 2021 The wide properties for the derivatives of 1,8-naphthalimide could facilitate further in-depth mechanistic studies of WZZ02 through various fluorescent physical and chemical methods, which could help to further understand the function of PDGFR-beta gene promoter G-quadruplex and i-motif. Naphthalimides 43-60 platelet derived growth factor receptor alpha Homo sapiens 238-248 32950500-0 2020 Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway. Naphthalimides 34-47 tumor protein p53 Homo sapiens 25-28 32950500-0 2020 Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway. Naphthalimides 34-47 tumor protein p53 Homo sapiens 140-143 32950500-0 2020 Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway. Naphthalimides 34-47 epidermal growth factor receptor Homo sapiens 144-148 32950500-3 2020 We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines. Naphthalimides 229-242 tumor protein p53 Homo sapiens 35-38 32950500-3 2020 We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines. Naphthalimides 229-242 tumor protein p53 Homo sapiens 108-111 32950500-3 2020 We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines. Naphthalimides 229-242 epidermal growth factor receptor Homo sapiens 112-116 32950500-3 2020 We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines. Naphthalimides 229-242 epidermal growth factor receptor Homo sapiens 118-150 32950500-3 2020 We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines. Naphthalimides 229-242 tumor protein p53 Homo sapiens 108-111 33904541-5 2021 The probe ER-DTT was based upon naphthalimide as a fluorophore, p-toluenesulfonamide as an exceptional unit for ER-targeting, and sulfoxide as a response site for imaging DTT based on an intramolecular charge transfer (ICT) mechanism. Naphthalimides 32-45 epiregulin Homo sapiens 10-12 33625414-0 2021 Luminescent naphthalimide-tagged ruthenium(II)-arene complexes: cellular imaging, photocytotoxicity and transferrin binding. Naphthalimides 12-25 transferrin Homo sapiens 104-115 33759126-6 2021 Template structure used to search for novel heterocyclic and carbocyclic fragments is 1,8-naphthalimide (CAP group of scriptaid, a potent HDAC inhibitor). Naphthalimides 86-103 histone deacetylase 9 Homo sapiens 138-142 33532593-0 2021 Effect of an alkyl spacer on the morphology and internalization of MUC1 aptamer-naphthalimide amphiphiles for targeting and imaging triple negative breast cancer cells. Naphthalimides 80-93 mucin 1, cell surface associated Homo sapiens 67-71 32276227-1 2020 A novel hydroxy functionalized naphthalimide-based fluorescent probe (denoted SP2)was successfully designed and synthesized for monitoring of H2S in living cells and environmental. Naphthalimides 31-44 Sp2 transcription factor Homo sapiens 78-81 32668630-1 2020 Three new 1,8-naphthalimide derivatives M1-M3 with different substituents at the C-4 position have been synthesized and characterized. Naphthalimides 10-27 complement C4A (Rodgers blood group) Homo sapiens 81-84 32270586-1 2020 We prepared conceptually novel, fully rigid, spiro compact electron donor (Rhodamine B, lactam form)/acceptor (naphthalimide) orthogonal dyad to attain the long-lived triplet charge transfer (3CT) state, based on the electron spin control using spin-orbit charge transfer intersystem crossing (SOCT-ISC). Naphthalimides 111-124 spindlin 1 Homo sapiens 226-230 32270586-1 2020 We prepared conceptually novel, fully rigid, spiro compact electron donor (Rhodamine B, lactam form)/acceptor (naphthalimide) orthogonal dyad to attain the long-lived triplet charge transfer (3CT) state, based on the electron spin control using spin-orbit charge transfer intersystem crossing (SOCT-ISC). Naphthalimides 111-124 spindlin 1 Homo sapiens 245-249 32270586-6 2020 With time-resolved electron paramagnetic resonance (TREPR) spectra, an EEEAAA electron-spin polarization pattern was observed for the naphthalimide-localized triplet state. Naphthalimides 134-147 spindlin 1 Homo sapiens 87-91 32037409-4 2020 NVP-AUY922 is a heat shock protein 90 (HSP90) inhibitor with preferential tumor selectivity that is conjugated to 4-hydroxy-1,8-naphthalimide as a tumor-targeting ligand. Naphthalimides 114-141 heat shock protein 90 alpha family class A member 1 Homo sapiens 16-37 32245186-6 2020 MT-1 was constructed by integrating the naphthalimide moiety (donor) and rhodamine B (accepter and targeting group) through a newly designed linker. Naphthalimides 40-53 metallothionein 1I, pseudogene Homo sapiens 0-4 32037409-4 2020 NVP-AUY922 is a heat shock protein 90 (HSP90) inhibitor with preferential tumor selectivity that is conjugated to 4-hydroxy-1,8-naphthalimide as a tumor-targeting ligand. Naphthalimides 114-141 heat shock protein 90 alpha family class A member 1 Homo sapiens 39-44 31861836-0 2019 Cancer-Specific hNQO1-Responsive Biocompatible Naphthalimides Providing a Rapid Fluorescent Turn-On with an Enhanced Enzyme Affinity. Naphthalimides 47-61 NAD(P)H quinone dehydrogenase 1 Homo sapiens 16-21 31892069-2 2020 L-pH is composed of three moieties, including naphthalimide fluorophore as a fluorescence off-on response moiety, piperazine and morpholine groups as lysosomal targeting and pH responsive sites, as well as a reactive benzyl chloride segment for further lysosomal anchoring. Naphthalimides 46-59 lactase Mus musculus 0-4 31844857-1 2020 A series of six different 1,8-naphthalimide conjugated dipicolylamine ligands (L1-6) have been synthesised and characterised. Naphthalimides 28-43 immunoglobulin kappa variable 3D-15 Homo sapiens 79-83 31670325-0 2019 A highly selective ratiometric fluorescent probe based on naphthalimide for detection and imaging of CYP1A1 in living cells and zebrafish. Naphthalimides 58-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 101-107 31670325-2 2019 Herein, according to slight differences in the 3D structure and substrate preference between CYP1A1 and its homologous CYP1A2, a series of novel ratiometric fluorescent probes were designed and synthesized using 1,8-naphthalimide because of its trait of naked-eye visualization and ratiometric fluorescence to achieve the detection of CYP1A1 in biological samples. Naphthalimides 212-229 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 93-99 31670325-2 2019 Herein, according to slight differences in the 3D structure and substrate preference between CYP1A1 and its homologous CYP1A2, a series of novel ratiometric fluorescent probes were designed and synthesized using 1,8-naphthalimide because of its trait of naked-eye visualization and ratiometric fluorescence to achieve the detection of CYP1A1 in biological samples. Naphthalimides 212-229 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 119-125 31670325-2 2019 Herein, according to slight differences in the 3D structure and substrate preference between CYP1A1 and its homologous CYP1A2, a series of novel ratiometric fluorescent probes were designed and synthesized using 1,8-naphthalimide because of its trait of naked-eye visualization and ratiometric fluorescence to achieve the detection of CYP1A1 in biological samples. Naphthalimides 212-229 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 335-341 31861836-3 2019 Herein, we report naphthalimide-based fluorescent probes 1 and 2 that can detect hNQO1. Naphthalimides 18-31 NAD(P)H quinone dehydrogenase 1 Homo sapiens 81-86 31036214-0 2019 A novel dithiourea-appended naphthalimide "on-off" fluorescent probe for detecting Hg2+ and Ag+ and its application in cell imaging. Naphthalimides 28-41 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 83-86 31343787-0 2019 Persistent Room-Temperature Radicals from Anionic Naphthalimides: Spin Pairing and Supramolecular Chemistry. Naphthalimides 50-64 spindlin 1 Homo sapiens 66-70 30995142-0 2019 UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway. Naphthalimides 20-33 AKT serine/threonine kinase 1 Homo sapiens 103-106 30995142-0 2019 UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway. Naphthalimides 20-33 mitogen-activated protein kinase 1 Homo sapiens 107-110 31490511-5 2019 Each of the three technetium-99m labelled naphthalimide complexes were successfully produced from fac-[99mTc(CO)3(H2O)3]+ in 15 minutes at 70 C and isolated in radiochemical yields ranging from 60-95% with radiochemical purities greater than 95%. Naphthalimides 42-55 FA complementation group C Homo sapiens 98-101 31143885-1 2019 A naphthalimide-aminal-based fluorescent donor (NAP-FAD-1) is a pH-sensitive smart donor, which features accelerated FA release at pH 5.0 compared to that at pH 7.4 and fluorescence turn-on readout for facile tracking and quantification of FA release. Naphthalimides 2-15 flavin adenine dinucleotide synthetase 1 Homo sapiens 52-57 30892331-0 2019 Insight into the delivery channel and selectivity of multiple binding sites in bovine serum albumin towards naphthalimide-polyamine derivatives. Naphthalimides 108-121 albumin Homo sapiens 86-99 30892331-3 2019 Herein, the delivery and binding of the naphthalimide-polyamine complex assisted by the bovine serum albumin (BSA) protein have been studied by combining several molecular dynamic simulations. Naphthalimides 40-53 albumin Homo sapiens 95-122 30629076-0 2019 Glycosylated naphthalimides and naphthalimide Troger"s bases as fluorescent aggregation probes for Con A. Herein we report the synthesis of fluorescent, glycosylated 4-amino-1,8-naphthalimide (Nap) 1, and the related 1,8-naphthalimides Troger"s bases (TBNap) 2 and 3, from 1,8-naphthalic anhydride precursors, the alpha-mannosides being introduced through the use of CuAAC mediated "click" chemistry. Naphthalimides 13-27 C-X-C motif chemokine ligand 8 Homo sapiens 166-199 30597284-1 2019 We have developed a FRET-based fluorescent probe (PHS1) as a combination of two different fluorophores (coumarin and naphthalimide); which can detect both exogenous and endogenous H2S and H2O2 in live cells through multicolor images. Naphthalimides 117-130 prostaglandin-endoperoxide synthase 1 Homo sapiens 50-54 30597284-2 2019 The precise overlap between UV-absorption of naphthalimide and the emission band of coumarin in probe PHS1 allows the acquisition of the self-calibrated information of dual analytes through FRET-based imaging. Naphthalimides 45-58 prostaglandin-endoperoxide synthase 1 Homo sapiens 102-106 29390898-2 2018 Based on the catalytic mechanism and structure of the catalytic domains of these beta-N-acetylhexosaminidases, a series of novel naphthalimide moiety-bearing thioglycosides with different flexible linkers were designed, and their inhibitory potency against hsHexB and hOGA was evaluated. Naphthalimides 129-142 O-GlcNAcase Homo sapiens 268-272 30544880-0 2018 A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway. Naphthalimides 58-71 mitogen-activated protein kinase 14 Homo sapiens 148-151 30544880-4 2018 Further analyses revealed a rapid and consistent activation of p38 signaling by the naphthalimide-NHC conjugates, with the Ru(II) analogue-termed MC6-showing the strongest effect. Naphthalimides 84-97 mitogen-activated protein kinase 14 Homo sapiens 63-66 30544880-7 2018 Altogether, our results provide new insight into the molecular mechanisms of naphthalimide-metal NHC analogues via the ROS-induced activation of p38 MAPK, which may have therapeutic interest for the treatment of various cancer types. Naphthalimides 77-90 mitogen-activated protein kinase 14 Homo sapiens 145-148 30168823-4 2018 Herein, a series of fluorescent HDAC6-selective inhibitors incorporating a naphthalimide skeleton were designed and synthesized. Naphthalimides 75-88 histone deacetylase 6 Homo sapiens 32-37 29375976-4 2018 One building block (cholesterol conjugated cynanostilbene, CCS) consists of cholesterol conjugated with a cynanostilbene unit, and the other one (C10CN) is comprised of cholesterol connected with a naphthalimide group having a flexible long alkyl chain. Naphthalimides 198-211 copper chaperone for superoxide dismutase Homo sapiens 59-62 29796828-0 2018 A Multi-Responsive Naphthalimide-Based "Turn-on" Fluorescent Chemosensor for Sensitive Detection of Trivalent Cations Ga3+, Al3+ and Cr3. Naphthalimides 19-32 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 133-136 29316508-0 2018 Synthesis and biological evaluation of naphthalimide-polyamine conjugates modified by alkylation as anticancer agents through p53 pathway. Naphthalimides 39-52 tumor protein p53 Homo sapiens 126-129 30156587-0 2018 A highly selective naphthalimide-based ratiometric fluorescent probe for the recognition of tyrosinase and cellular imaging. Naphthalimides 19-32 tyrosinase Homo sapiens 92-102 30156587-2 2018 Therefore, for the recognition of tyrosinase, naphthalimide-based ratiometric fluorescent sensor probe was designed and synthesized. Naphthalimides 46-59 tyrosinase Homo sapiens 34-44 29698606-4 2018 The intramolecular charge transfer (ICT) interactions in the resulting BN-fused naphthalimides (BN0-BN3) together with their precursors (N0-N3) and fluoride-coordinated analogues (FBN0-FBN3) have been systematically investigated by photophysical, electrochemical, and theoretical approaches. Naphthalimides 80-94 fibrillin 3 Homo sapiens 185-189 29072615-8 2017 Collectively, our data show that LSS-11 is a potent naphthalimide-based chemosensitizer that could enhance cell death in paclitaxel-resistant lung cancer cells through the DR5/PARP1 pathway and STAT3/MDR1/MRP1 STAT3 inhibition. Naphthalimides 52-65 TNF receptor superfamily member 10b Homo sapiens 172-175 28849853-0 2017 A novel supramolecular polymer gel based on naphthalimide functionalized-pillar[5]arene for the fluorescence detection of Hg2+ and I- and recyclable removal of Hg2+via cation-pi interactions. Naphthalimides 44-57 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 122-125 28849853-0 2017 A novel supramolecular polymer gel based on naphthalimide functionalized-pillar[5]arene for the fluorescence detection of Hg2+ and I- and recyclable removal of Hg2+via cation-pi interactions. Naphthalimides 44-57 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 160-163 29072615-8 2017 Collectively, our data show that LSS-11 is a potent naphthalimide-based chemosensitizer that could enhance cell death in paclitaxel-resistant lung cancer cells through the DR5/PARP1 pathway and STAT3/MDR1/MRP1 STAT3 inhibition. Naphthalimides 52-65 signal transducer and activator of transcription 3 Homo sapiens 194-199 28737377-0 2017 Carbon Dot Based, Naphthalimide Coupled FRET Pair for Highly Selective Ratiometric Detection of Thioredoxin Reductase and Cancer Screening. Naphthalimides 18-31 peroxiredoxin 5 Homo sapiens 96-117 28675031-7 2017 In the proposed design, a donor-pi-acceptor (D-pi-A) structured naphthalimide derivative with efficient two-photon properties was chosen as the fluorescent group, and a 2,4-dinitrobenzenesulfonate group was employed as the GST recognition unit, which also acted as the fluorescence quencher. Naphthalimides 64-77 glutathione S-transferase kappa 1 Homo sapiens 223-226 28737377-1 2017 The fluorescence resonance energy transfer (FRET) mechanism has been established between carbon dots (CDs) and naphthalimide to monitor the activity of thioredoxin reductase (TrxR), which is often overexpressed in many cancer cells. Naphthalimides 111-124 peroxiredoxin 5 Homo sapiens 152-173 28737377-1 2017 The fluorescence resonance energy transfer (FRET) mechanism has been established between carbon dots (CDs) and naphthalimide to monitor the activity of thioredoxin reductase (TrxR), which is often overexpressed in many cancer cells. Naphthalimides 111-124 peroxiredoxin 5 Homo sapiens 175-179 28737377-4 2017 However, contrary to this, the elevated levels of TrxR cause the breakage of disulfide bonds and consequently abolishes the FRET pair through the release of the naphthalimide moiety from the surface of CDs. Naphthalimides 161-174 peroxiredoxin 5 Homo sapiens 50-54 28527428-5 2017 Due to their unique optical properties and their many uses in different areas such as supramolecular chemistry or biomedicine, we have chosen a derivative from the family of naphthalimides (the 4-amino-1,8-naphthalimide-N-substituted; ANN) to study the interaction with different CNPs (CNP1-4) and their joint bioactivity compared to that of the same compounds alone. Naphthalimides 174-188 2',3'-cyclic nucleotide 3' phosphodiesterase Homo sapiens 286-292 28524357-4 2017 For the construction of antibody-probe conjugates from an anti-carcinoembryonic antigen and a quinone-caged profluorescent naphthalimide derivative, the dual "click" coupling process with C1 was monitored on the basis of the emission turn-on of C1, whereas prominent changes in FRET ratios occurred for antibody-imaging-probe conjugates when specifically triggered by quinone oxidoreductase (NQO1), which is overexpressed in various types of cancer cells. Naphthalimides 123-136 crystallin zeta Homo sapiens 368-390 28524357-4 2017 For the construction of antibody-probe conjugates from an anti-carcinoembryonic antigen and a quinone-caged profluorescent naphthalimide derivative, the dual "click" coupling process with C1 was monitored on the basis of the emission turn-on of C1, whereas prominent changes in FRET ratios occurred for antibody-imaging-probe conjugates when specifically triggered by quinone oxidoreductase (NQO1), which is overexpressed in various types of cancer cells. Naphthalimides 123-136 NAD(P)H quinone dehydrogenase 1 Homo sapiens 392-396 28110683-3 2017 By contrast, probes 2 and 3 possessing 1,8-naphthalimide and pyrene fluorophores, respectively, exhibited selective fluorescent "OFF-ON" behaviors as a result of Ga3+/Al3+ binding among the diverse metal ions, suggesting the importance of fluorophore electronic character with regard to metal ion sensing. Naphthalimides 39-56 succinyl-CoA:glutarate-CoA transferase Homo sapiens 162-165 28343244-0 2017 A New Reactive 1,8-Naphthalimide Derivative for Highly Selective and Sensitive Detection of Hg2. Naphthalimides 15-32 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 92-95 28451319-1 2017 Donor-acceptor-acceptor (D-A-A) type 1,8-naphthalimide based small molecules SM1 and SM2 functionalized with tetracyanobutadiene (TCBD) and dicyanoquino-dimethane (DCNQ) modules, showing strong absorption in the visible and near-infrared (NIR) region are reported. Naphthalimides 37-54 SM1 Homo sapiens 77-80 28451319-1 2017 Donor-acceptor-acceptor (D-A-A) type 1,8-naphthalimide based small molecules SM1 and SM2 functionalized with tetracyanobutadiene (TCBD) and dicyanoquino-dimethane (DCNQ) modules, showing strong absorption in the visible and near-infrared (NIR) region are reported. Naphthalimides 37-54 SM2 Homo sapiens 85-88 26668309-0 2016 A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak Bcl-xl Complex and Triggering Transcriptional Regulation. Naphthalimides 8-21 tumor protein p53 Homo sapiens 40-43 26845638-1 2016 Four small molecular acceptors (SM1-4) comprising a central benzene core, two thiophene bridges and two 1,8-naphthalimide (NI) terminal groups were designed and synthesized by direct C-H activation. Naphthalimides 104-121 SM1 Homo sapiens 32-37 27997743-0 2017 Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents. Naphthalimides 25-38 high mobility group nucleosomal binding domain 4 Homo sapiens 6-9 27626909-4 2016 NADE used 1,8-naphthalimide as the signal reporter and adenosine (Ade) as the reaction center; removal of the Ade moiety enhanced the fluorescence by >10-fold. Naphthalimides 10-27 brain expressed X-linked 3 Homo sapiens 0-4 27651806-5 2016 Hence, in this research, we focused on the synthesis of naphthalimide analogs as potential 15-LOX-1 inhibitors. Naphthalimides 56-69 arachidonate 15-lipoxygenase Homo sapiens 91-99 27651806-7 2016 Naphthalimide derivatives could be suggested as potential LOX inhibitors with likely applications of anticancer activity. Naphthalimides 0-13 lysyl oxidase Homo sapiens 58-61 26668309-0 2016 A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak Bcl-xl Complex and Triggering Transcriptional Regulation. Naphthalimides 8-21 BCL2 antagonist/killer 1 Homo sapiens 103-106 26668309-0 2016 A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak Bcl-xl Complex and Triggering Transcriptional Regulation. Naphthalimides 8-21 BCL2 like 1 Homo sapiens 107-113 26668309-8 2016 This work provided new insights into the molecular interactions and anticancer mechanisms of phospho-p53-dependent naphthalimide compounds. Naphthalimides 115-128 tumor protein p53 Homo sapiens 101-104 25196578-3 2014 Here, we developed a highly sensitive and versatile ratiometric H2O2 fluorescent probe (NP1) based on 1,8-naphthalimide and boric acid ester. Naphthalimides 102-119 neuronal pentraxin 1 Homo sapiens 88-91 25991384-0 2016 Investigations on the interactions between naphthalimide-based anti-tumor drugs and human serum albumin by spectroscopic and molecular modeling methods. Naphthalimides 43-56 albumin Homo sapiens 90-103 25991384-1 2016 The interactions between the three kinds of naphthalimide-based anti-tumor drugs (NADA, NADB, NADC) and human serum albumin (HSA) under simulated physiological conditions were investigated by fluorescence spectroscopy, circular dichroism spectroscopy and molecular modeling. Naphthalimides 44-57 albumin Homo sapiens 110-123 26378511-0 2015 Spectroscopic Study on the Interaction between Naphthalimide-Polyamine Conjugates and Bovine Serum Albumin (BSA). Naphthalimides 47-60 albumin Homo sapiens 93-106 26378511-1 2015 The effect of a naphthalimide pharmacophore coupled with diverse substituents on the interaction between naphthalimide-polyamine conjugates 1-4 and bovine serum albumin (BSA) was studied by UV absorption, fluorescence and circular dichroism (CD) spectroscopy under physiological conditions (pH = 7.4). Naphthalimides 16-29 albumin Homo sapiens 155-168 26378511-1 2015 The effect of a naphthalimide pharmacophore coupled with diverse substituents on the interaction between naphthalimide-polyamine conjugates 1-4 and bovine serum albumin (BSA) was studied by UV absorption, fluorescence and circular dichroism (CD) spectroscopy under physiological conditions (pH = 7.4). Naphthalimides 105-118 albumin Homo sapiens 155-168 25730340-0 2015 Sensitization of cisplatin therapy by a naphthalimide based organoselenium compound through modulation of antioxidant enzymes and p53 mediated apoptosis. Naphthalimides 40-53 transformation related protein 53, pseudogene Mus musculus 130-133 32261982-4 2015 The presence of ALP cleaves the phosphate group from naphthalimide and remarkably alters the probe"s photophysical properties, thus achieving ratiometric detection of ALP. Naphthalimides 53-66 alkaline phosphatase, placental Homo sapiens 16-19 32261982-4 2015 The presence of ALP cleaves the phosphate group from naphthalimide and remarkably alters the probe"s photophysical properties, thus achieving ratiometric detection of ALP. Naphthalimides 53-66 alkaline phosphatase, placental Homo sapiens 167-170 26816264-0 2016 Design, Synthesis, and Proticity Inclined Conformational Modulation in a Highly Fluorescent Bichromophoric Naphthalimide Derivative: Hint Directed from RICT Perspective. Naphthalimides 107-120 histidine triad nucleotide binding protein 1 Homo sapiens 133-137 24723120-0 2014 A naphthalimide-based bifunctional fluorescent probe for the differential detection of Hg2+ and Cu2+ in aqueous solution. Naphthalimides 2-15 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 87-90 24803348-0 2014 Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators. Naphthalimides 46-59 peroxiredoxin 5 Homo sapiens 80-101 24803348-2 2014 The complexes were potent DNA intercalators related to their naphthalimide partial structure, inhibited TrxR as a consequence of the incorporation of the gold(I) moiety, and triggered efficient cytotoxic effects in MCF-7 breast and HT-29 colon adenocarcinoma cells. Naphthalimides 61-74 peroxiredoxin 5 Homo sapiens 104-108 24919009-3 2014 A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was investigated as a Cu(2+) selective fluorescent sensor in living cells. Naphthalimides 8-21 natriuretic peptide B Homo sapiens 67-70 24723120-1 2014 A novel fluorescent probe NPM based on naphthalimide was designed and synthesized. Naphthalimides 39-52 nucleophosmin 1 Homo sapiens 26-29 24013474-1 2013 We demonstrate that replacing the hydrazone linkage by a linear pi-spacer bridging a carbazole donor and a naphthalimide acceptor induces a critical change in molecular organization and electron density distribution in the conjugation backbone that correlates with a remarkable variation of memory performance from DRAM to WORM types. Naphthalimides 107-120 DNA damage regulated autophagy modulator 1 Homo sapiens 315-319 24351040-3 2014 TRFS-green displays a green fluorescence off-on change induced by the TrxR-mediated disulfide cleavage and subsequent intramolecular cyclization to liberate the masked naphthalimide fluorophore. Naphthalimides 168-181 peroxiredoxin 5 Homo sapiens 70-74 24351040-5 2014 HPLC analyses indicated that TRFS-green was exclusively converted to naphthalimide catalyzed by TrxR. Naphthalimides 69-82 peroxiredoxin 5 Homo sapiens 96-100 23810913-3 2013 The newly designed probe 1 contains a propargylamine moiety at C-4 of the naphthalimide chromophore that reacts with Au(3+) to generate a product that has distinctly different electronic properties from 1. Naphthalimides 74-87 complement C4A (Rodgers blood group) Homo sapiens 63-66 23810444-0 2013 7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-kappaB in LPS-stimulated RAW264.7 macrophages. Naphthalimides 12-25 mitogen-activated protein kinase kinase kinase 7 Mus musculus 98-102 23810444-0 2013 7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-kappaB in LPS-stimulated RAW264.7 macrophages. Naphthalimides 12-25 mitogen-activated protein kinase 3 Mus musculus 132-138 23810444-0 2013 7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-kappaB in LPS-stimulated RAW264.7 macrophages. Naphthalimides 12-25 mitogen-activated protein kinase 14 Mus musculus 144-147 23810444-0 2013 7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-kappaB in LPS-stimulated RAW264.7 macrophages. Naphthalimides 12-25 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 176-185 23165407-0 2013 Simple naphthalimide-based fluorescent sensor for highly sensitive and selective detection of Cd2+ and Cu2+ in aqueous solution and living cells. Naphthalimides 7-20 CD2 molecule Homo sapiens 94-97 23994328-1 2013 A series of amine substituted naphthalimide analogue were synthesized and evaluated for in vitro anti-tumour activities against 60 tumour cell lines at a single dose concentration of 10 muM. Naphthalimides 30-43 latexin Homo sapiens 186-189 21909097-5 2011 The antiviral activity of naphthalimides was abolished in REDD1(-/-) cells. Naphthalimides 26-40 DNA damage inducible transcript 4 Homo sapiens 58-63 23174889-1 2013 In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed and synthesized, which can be recognized and hydrolyzed by aminopeptidase N (APN) at both the enzymatic and cellular level by following the fluorescent emission wavelength change from blue to green light. Naphthalimides 102-115 alanyl aminopeptidase, membrane Homo sapiens 206-222 23174889-1 2013 In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed and synthesized, which can be recognized and hydrolyzed by aminopeptidase N (APN) at both the enzymatic and cellular level by following the fluorescent emission wavelength change from blue to green light. Naphthalimides 102-115 alanyl aminopeptidase, membrane Homo sapiens 224-227 22932925-0 2012 FRET-based ratiometric detection of Hg2+ and biothiols using naphthalimide-rhodamine dyads. Naphthalimides 61-74 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 36-39 22026405-1 2011 Two novel photochromic naphthopyrans containing naphthalimide moieties (Nip1 and Nip2) were studied in solution under flash photolysis conditions, exhibiting highly photochromic response, rapid thermal bleaching rate and good fatigue-resistance. Naphthalimides 48-61 BCL2 interacting protein 1 Homo sapiens 72-76 22026405-1 2011 Two novel photochromic naphthopyrans containing naphthalimide moieties (Nip1 and Nip2) were studied in solution under flash photolysis conditions, exhibiting highly photochromic response, rapid thermal bleaching rate and good fatigue-resistance. Naphthalimides 48-61 BCL2 interacting protein 2 Homo sapiens 81-85 22026405-2 2011 Owing to the different N-substituted imide groups at the naphthalimide units, the thermal bleaching rate of Nip2 bearing phenyl on the naphthalimide unit is found to be approximately 2 times that of Nip1 bearing n-butyl, indicating that the photochromic properties can be modulated with introduction of different functional groups on the naphthalimide unit. Naphthalimides 57-70 BCL2 interacting protein 2 Homo sapiens 108-112 22026405-2 2011 Owing to the different N-substituted imide groups at the naphthalimide units, the thermal bleaching rate of Nip2 bearing phenyl on the naphthalimide unit is found to be approximately 2 times that of Nip1 bearing n-butyl, indicating that the photochromic properties can be modulated with introduction of different functional groups on the naphthalimide unit. Naphthalimides 135-148 BCL2 interacting protein 2 Homo sapiens 108-112 22026405-2 2011 Owing to the different N-substituted imide groups at the naphthalimide units, the thermal bleaching rate of Nip2 bearing phenyl on the naphthalimide unit is found to be approximately 2 times that of Nip1 bearing n-butyl, indicating that the photochromic properties can be modulated with introduction of different functional groups on the naphthalimide unit. Naphthalimides 135-148 BCL2 interacting protein 2 Homo sapiens 108-112 22026405-3 2011 In Nip1 and Nip2, the strong electron-withdrawing effect of the imide group incorporated at the naphthalimide moiety maintains several merits: (i) shifting absorption bands to longer wavelength, (ii) beneficial to an enhancement in the ratio of transoid-cis (TC) isomer and an increase in the transformation rate from transoid-trans (TT) to TC with respect to reference compound NP, and (iii) resulting in a preferable color bleaching rate and fading absolutely to their colorless state with thermal reversibility. Naphthalimides 96-109 BCL2 interacting protein 1 Homo sapiens 3-7 22026405-3 2011 In Nip1 and Nip2, the strong electron-withdrawing effect of the imide group incorporated at the naphthalimide moiety maintains several merits: (i) shifting absorption bands to longer wavelength, (ii) beneficial to an enhancement in the ratio of transoid-cis (TC) isomer and an increase in the transformation rate from transoid-trans (TT) to TC with respect to reference compound NP, and (iii) resulting in a preferable color bleaching rate and fading absolutely to their colorless state with thermal reversibility. Naphthalimides 96-109 BCL2 interacting protein 2 Homo sapiens 12-16 19881958-0 2009 Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells. Naphthalimides 0-14 ATM serine/threonine kinase Homo sapiens 46-49 21807232-1 2011 A novel Cu(2+)-specific "off-on" fluorescent chemosensor of naphthalimide modified rhodamine B (naphthalimide modified rhodamine B chemosensor, NRC) was designed and synthesized, based on the equilibrium between the spirolactam (non-fluorescence) and the ring-opened amide (fluorescence). Naphthalimides 60-73 nuclear receptor coactivator 6 Homo sapiens 144-147 21807232-1 2011 A novel Cu(2+)-specific "off-on" fluorescent chemosensor of naphthalimide modified rhodamine B (naphthalimide modified rhodamine B chemosensor, NRC) was designed and synthesized, based on the equilibrium between the spirolactam (non-fluorescence) and the ring-opened amide (fluorescence). Naphthalimides 96-109 nuclear receptor coactivator 6 Homo sapiens 144-147 20179988-0 2011 B1, a novel naphthalimide-based DNA intercalator, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation. Naphthalimides 12-25 tumor protein p53 Homo sapiens 108-111 20399137-2 2010 N,N-Dimetylaminoethylamino group has been used as substituent at C-4 position of the 1,8-naphthalimide chromophore structure. Naphthalimides 85-102 complement C4A (Rodgers blood group) Homo sapiens 65-68 21821060-3 2011 Treatment with naphthalimide-based DNA intercalators, including M2-A and R16, generally leads to a decrease in Bcl-2 intracellular amounts. Naphthalimides 15-28 BCL2 apoptosis regulator Homo sapiens 111-116 21821060-5 2011 We report here that p53 contributes to Bcl-2 down-regulation induced by B1, a novel naphthalimide-based DNA intercalating agent. Naphthalimides 84-97 tumor protein p53 Homo sapiens 20-23 21821060-5 2011 We report here that p53 contributes to Bcl-2 down-regulation induced by B1, a novel naphthalimide-based DNA intercalating agent. Naphthalimides 84-97 BCL2 apoptosis regulator Homo sapiens 39-44 21821060-10 2011 Our study strengthens the links between p53 and Bcl-2 at a transcriptional level, upon naphthalimide-based DNA intercalator treatment. Naphthalimides 87-100 tumor protein p53 Homo sapiens 40-43 21821060-10 2011 Our study strengthens the links between p53 and Bcl-2 at a transcriptional level, upon naphthalimide-based DNA intercalator treatment. Naphthalimides 87-100 BCL2 apoptosis regulator Homo sapiens 48-53 20539874-1 2010 FRET cassette-type sensors, SN-1 and SN-2, which contain two naphthalimide donors and a squaraine acceptor, have been developed on the concept of switching off FRET through removing the spectral overlap by the analyte-induced decompositions of acceptor chromophore. Naphthalimides 61-74 solute carrier family 38 member 3 Homo sapiens 28-32 20539874-1 2010 FRET cassette-type sensors, SN-1 and SN-2, which contain two naphthalimide donors and a squaraine acceptor, have been developed on the concept of switching off FRET through removing the spectral overlap by the analyte-induced decompositions of acceptor chromophore. Naphthalimides 61-74 solute carrier family 38 member 5 Homo sapiens 37-41 19881958-0 2009 Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells. Naphthalimides 0-14 checkpoint kinase 2 Homo sapiens 60-64 19881958-1 2009 Naphthalimides, particularly amonafide and 2-(2-dimethylamino)-6-thia-2-aza-benzo[def]chrysene-1,3-diones (R16), have been identified to possess anticancer activities and to induce G(2)-M arrest through inhibiting topoisomerase II accompanied by Chk1 degradation. Naphthalimides 0-14 solute carrier family 1 member 5 Homo sapiens 107-110 19881958-1 2009 Naphthalimides, particularly amonafide and 2-(2-dimethylamino)-6-thia-2-aza-benzo[def]chrysene-1,3-diones (R16), have been identified to possess anticancer activities and to induce G(2)-M arrest through inhibiting topoisomerase II accompanied by Chk1 degradation. Naphthalimides 0-14 checkpoint kinase 1 Homo sapiens 246-250 19881958-7 2009 Moreover, the naphthalimides phosphorylated Chk2 in an ATM-dependent manner but induced Chk1 degradation. Naphthalimides 14-28 checkpoint kinase 2 Homo sapiens 44-48 19881958-7 2009 Moreover, the naphthalimides phosphorylated Chk2 in an ATM-dependent manner but induced Chk1 degradation. Naphthalimides 14-28 ATM serine/threonine kinase Homo sapiens 55-58 19881958-7 2009 Moreover, the naphthalimides phosphorylated Chk2 in an ATM-dependent manner but induced Chk1 degradation. Naphthalimides 14-28 checkpoint kinase 1 Homo sapiens 88-92 19881958-9 2009 Thus, a clear signaling pathway can be established, in which ATM relays the DNA DSBs signaling triggered by the naphthalimides to the checkpoint kinases, predominantly to Chk2,which finally elicits G(2) arrest. Naphthalimides 112-126 ATM serine/threonine kinase Homo sapiens 61-64 19881958-9 2009 Thus, a clear signaling pathway can be established, in which ATM relays the DNA DSBs signaling triggered by the naphthalimides to the checkpoint kinases, predominantly to Chk2,which finally elicits G(2) arrest. Naphthalimides 112-126 checkpoint kinase 2 Homo sapiens 171-175 19048148-0 2008 Highly sensitive and selective Pd2+ sensor of naphthalimide derivative based on complexation with alkynes and thio-heterocycle. Naphthalimides 46-59 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 31-34 19865701-0 2009 Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway. Naphthalimides 27-41 AKT serine/threonine kinase 1 Homo sapiens 90-93 19865701-0 2009 Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway. Naphthalimides 27-41 mechanistic target of rapamycin kinase Homo sapiens 94-98 18646861-4 2008 Interaction of the urea receptor with anions (F (-), AcO (-), H 2PO 4 (-)) via hydrogen bonding or urea NH deprotonation resulted in significant fluorescence quenching of the 1,8-naphthalimide chromophore in an appropriately chosen model compound (ca. Naphthalimides 175-192 kallikrein related peptidase 15 Homo sapiens 53-56 16154757-2 2005 In this paper, the synthesis of the compound, photophysics of the newly prepared naphthalimide derivative and its interaction with model transport protein Bovine serum albumin (BSA) have been reported using the absorption and steady state fluorescence spectroscopic techniques exploiting the intrinsic fluorescence emission properties of BSA as a probe. Naphthalimides 81-94 albumin Homo sapiens 162-175 18633498-1 2008 On the basis of fluorescent resonance energy transfer from 1,8-naphthalimide to rhodamine, a fluorophore dyad (FD8) containing rhodamine and a naphthalimide moiety was synthesized as a Cr3+-selective fluorescent probe for monitoring Cr3+ in living cells with ratiometric fluorescent methods. Naphthalimides 59-76 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 185-188 18633498-1 2008 On the basis of fluorescent resonance energy transfer from 1,8-naphthalimide to rhodamine, a fluorophore dyad (FD8) containing rhodamine and a naphthalimide moiety was synthesized as a Cr3+-selective fluorescent probe for monitoring Cr3+ in living cells with ratiometric fluorescent methods. Naphthalimides 63-76 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 185-188