PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22367855-7	2012	Following CCK-8-induced exocytosis, amylase-positive ZGs appeared to move towards the periphery of the cell and co-localization between Rab3D and amylase was less complete when compared to basal conditions.	Sincalide	10-15	RAB3D, member RAS oncogene family	Rattus norvegicus	136-141
22157031-5	2012	RESULTS: The panel recommended the use of a single, standardized, recently described CCK-CS protocol that involves infusion of 0.02 mug/kg of sincalide over 60 minutes with a normal GBEF defined as >=38%.	Sincalide	142-151	cholecystokinin	Homo sapiens	85-88
22470346-5	2012	Our results demonstrated that both CID755673 and CRT0066101 are PKD-specific inhibitors and that PKD/PKD1 inhibition by either the chemical inhibitors or specific PKD/PKD1 siRNAs attenuated necrosis while promoting apoptosis induced by pathological doses of cholecystokinin-octapeptide (CCK) in pancreatic acinar cells.	Sincalide	258-285	polycystin 1, transient receptor potential channel interacting	Rattus norvegicus	101-105
19445970-7	2009	Respective addition of cholecystokinin octapeptide and somatostatin with increasing concentrations caused rapid, sustained, concentration-dependent increase and decrease in muscle contraction of gastric antral strips, and cholecystokinin octapeptide that increased the contractile response could be blocked by respective administration of nifedipine and somatostatin significantly.	Sincalide	23-50	somatostatin	Rattus norvegicus	354-366
19710211-1	2009	OBJECTIVE: Both sonography and scintigraphy have been used to evaluate gallbladder function with the use of sincalide (cholecystokinin [CCK]).	Sincalide	108-117	cholecystokinin	Homo sapiens	119-134
19710211-1	2009	OBJECTIVE: Both sonography and scintigraphy have been used to evaluate gallbladder function with the use of sincalide (cholecystokinin [CCK]).	Sincalide	108-117	cholecystokinin	Homo sapiens	136-139
21664492-7	2011	The inhibitory action of CCK-8 was mainly mediated through the CCK2R pathway.	Sincalide	25-30	cholecystokinin B receptor	Homo sapiens	63-68
21334459-5	2011	RESULTS: The panel recommended the use of a single, standardized, recently described CCK-CS protocol that involves infusion of 0.02 mug/kg of sincalide over 60 minutes with a normal gallbladder ejection fraction defined as >=38%.	Sincalide	142-151	cholecystokinin	Homo sapiens	85-88
21163296-9	2011	Conversely, the administration of the CB1 agonist WIN 55,212-2 (2 mg/kg) reduced satiety induced by CCK-8.	Sincalide	100-105	cannabinoid receptor 1	Rattus norvegicus	38-41
21078593-1	2011	Intravenous cholecystokinin octapeptide (CCK-8) elicits vago-vagal reflexes that inhibit phasic gastric contractions and reduce gastric tone in urethane-anaesthetized rats.	Sincalide	12-39	cholecystokinin	Rattus norvegicus	41-44
20671193-9	2010	Furthermore, TUDCA prevented the CCK-8-induced BiP upregulation, diminished PERK and JNK phosphorylation, and prohibited the expression of CHOP, caspase 3 activation and apoptosis.	Sincalide	33-38	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	47-50
20671193-9	2010	Furthermore, TUDCA prevented the CCK-8-induced BiP upregulation, diminished PERK and JNK phosphorylation, and prohibited the expression of CHOP, caspase 3 activation and apoptosis.	Sincalide	33-38	mitogen-activated protein kinase 8	Rattus norvegicus	85-88
20671193-9	2010	Furthermore, TUDCA prevented the CCK-8-induced BiP upregulation, diminished PERK and JNK phosphorylation, and prohibited the expression of CHOP, caspase 3 activation and apoptosis.	Sincalide	33-38	DNA-damage inducible transcript 3	Rattus norvegicus	139-143
20671193-9	2010	Furthermore, TUDCA prevented the CCK-8-induced BiP upregulation, diminished PERK and JNK phosphorylation, and prohibited the expression of CHOP, caspase 3 activation and apoptosis.	Sincalide	33-38	caspase 3	Rattus norvegicus	145-154
17928640-3	2007	Inhibition of sarcoendoplasmic reticulum Ca(2+)-ATPase (SERCA) activity by 1 microM thapsigargin, preincubation in the presence of 100 microM H(2)O(2) or inhibition of PKC with either 5 microM Ro31-8220 or 3 microM GF-109203-X all led to a faster propagation of CCK-8-induced Ca(2+) signals.	Sincalide	262-267	ATPase, Ca++ transporting, ubiquitous	Mus musculus	14-54
19910677-15	2009	The Hsp90 inhibitor, geldanamycin, inhibited CCK-8-induced amylase release from these cells in a dose-dependent manner.	Sincalide	45-50	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	4-9
17928640-3	2007	Inhibition of sarcoendoplasmic reticulum Ca(2+)-ATPase (SERCA) activity by 1 microM thapsigargin, preincubation in the presence of 100 microM H(2)O(2) or inhibition of PKC with either 5 microM Ro31-8220 or 3 microM GF-109203-X all led to a faster propagation of CCK-8-induced Ca(2+) signals.	Sincalide	262-267	ATPase, Ca++ transporting, ubiquitous	Mus musculus	56-61
17259012-1	2007	Cholecystokinin octapeptide (CCK-8) is a physiological antagonist of endogenous opioids in the central nervous system (CNS).	Sincalide	29-34	cholecystokinin	Mus musculus	0-15
17510194-1	2007	In mice, eNOS (endothelial nitric oxide synthase) maintains in vivo pancreatic secretory responses to carbachol or cholecystokinin octapeptide (CCK-8), maintains insulin sensitivity, and modulates pancreatic microvascular blood flow (PMBF).	Sincalide	115-142	cholecystokinin	Mus musculus	144-147
15929179-0	2005	Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi.	Sincalide	42-47	VIP peptides	Oryctolagus cuniculus	35-38
17129639-4	2007	CCK-8 markedly suppressed ghrelin and stimulated PYY when compared with control between t=0-120 min (P<0.001 for both).	Sincalide	0-5	peptide YY	Homo sapiens	49-52
16791842-5	2006	Activation of caspase-3 by physiological concentrations of cellular agonists, including thrombin or CCK-8, is independent of rises in cytosolic calcium concentration but requires PKC activation, and is necessary for agonist-induced activation of the tyrosine kinases Btk and pp60src and for several cellular functions, including store-operated calcium entry, platelet aggregation, or pancreatic secretion.	Sincalide	100-105	caspase 3	Homo sapiens	14-23
16791842-5	2006	Activation of caspase-3 by physiological concentrations of cellular agonists, including thrombin or CCK-8, is independent of rises in cytosolic calcium concentration but requires PKC activation, and is necessary for agonist-induced activation of the tyrosine kinases Btk and pp60src and for several cellular functions, including store-operated calcium entry, platelet aggregation, or pancreatic secretion.	Sincalide	100-105	Bruton tyrosine kinase	Homo sapiens	267-270
16297350-8	2005	This inhibitory effect of CCK-8 could be abrogated partly by proglumide (non-selective CCK receptor antagonist), CR-1409 (selective CCK-A receptor antagonist), and CR-2945 (selective CCK-B receptor antagonist) in a concentration-dependent manner (P< 0.01).	Sincalide	26-31	cholecystokinin A receptor	Rattus norvegicus	132-146
15904713-4	2005	CCK-8 inhibited intake in this test and its inhibitory effect was increased by simultaneous treatment with NPY.	Sincalide	0-5	neuropeptide Y	Rattus norvegicus	107-110
15904713-5	2005	The activity in the nucleus of the solitary tract (NTS), a brainstem relay mediating inhibition of intake, judged by the expression of c-fos-like immunoreactivity, was significantly increased after treatment with CCK-8 or NPY to approximately the same extent.	Sincalide	213-218	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	135-140
15313209-6	2004	CCK-8 stimulation resulted in a fourfold increase in amylase secretion with or without GP2 expression.	Sincalide	0-5	glycoprotein 2	Rattus norvegicus	87-90
15159445-5	2004	To determine which transporter is more important for its hepatic uptake, we proposed a methodology for estimating their quantitative contribution to the overall hepatic uptake by comparing the uptake clearance of pitavastatin with that of reference compounds (a selective substrate for OATP2 (estrone-3-sulfate) and OATP8 (cholecystokinin octapeptide) in expression systems and human hepatocytes.	Sincalide	323-350	solute carrier organic anion transporter family member 1B1	Homo sapiens	286-291
12932837-7	2003	In vivo extracellular recordings of gastric distension-responsive CA3 neurons revealed that intracerebroventricular administration of motilin increased firing while CCK-8 inhibited firing.	Sincalide	165-170	carbonic anhydrase 3	Rattus norvegicus	66-69
15188507-7	2004	The specific HO-1 inhibitor- ZnPPIX could worsen LPS-induced injuries and weaken the protective effect of CCK-8.	Sincalide	106-111	heme oxygenase 1	Homo sapiens	13-17
14715522-9	2004	The CCK(A) receptor antagonist devazepide (500 microg/kg intravenous) inhibited motion responses evoked by intravenous CCK-8.	Sincalide	119-124	cholecystokinin A receptor	Rattus norvegicus	4-19
14519786-4	2003	CRHSP-28 was highly phosphorylated in isolated acini after stimulation with a physiologic range of concentrations of cholecystokinin-octapeptide (CCK-8).	Sincalide	117-144	calcium regulated heat stable protein-28	Rattus norvegicus	0-8
14519786-4	2003	CRHSP-28 was highly phosphorylated in isolated acini after stimulation with a physiologic range of concentrations of cholecystokinin-octapeptide (CCK-8).	Sincalide	117-144	cholecystokinin	Rattus norvegicus	146-149
12100748-7	2002	CCK-B receptor antagonist L-365,260 (30 nmol/L) reversed the antagonism of CCK-8 to the effect of morphine.	Sincalide	75-80	cholecystokinin B receptor	Rattus norvegicus	0-14
12890998-0	2003	Inhibitory effects of human and porcine alpha-amylase on CCK-8-stimulated lipase secretion of isolated rat pancreatic acini.	Sincalide	57-62	lipase G, endothelial type	Rattus norvegicus	74-80
12794305-1	2003	The Cholecystokinin type 1 and type 2 receptors (CCK-1R and CCK-2R) share >50% amino acid identity, as well as subnanomolar affinity for the endogenous peptide cholecystokinin octapeptide (CCK-8).	Sincalide	163-190	cholecystokinin A receptor	Homo sapiens	49-55
12794305-1	2003	The Cholecystokinin type 1 and type 2 receptors (CCK-1R and CCK-2R) share >50% amino acid identity, as well as subnanomolar affinity for the endogenous peptide cholecystokinin octapeptide (CCK-8).	Sincalide	163-190	cholecystokinin B receptor	Homo sapiens	60-66
12100748-9	2002	The antagonistic effect of CCK-8 on morphine was mainly mediated by CCK-B receptor.	Sincalide	27-32	cholecystokinin B receptor	Rattus norvegicus	68-82
11755115-1	2001	In the present study we have employed fura-2 loaded isolated mouse pancreatic acinar cells to monitor the effect that xanthine oxidase (XOD)-catalyzed reactive oxygen species generation presents on Ca(2+) mobilization by the secretagogue cholecystokinin octapeptide (CCK-8).	Sincalide	238-265	xanthine dehydrogenase	Mus musculus	118-134
11874552-10	2002	CCK-8 induced a slight increase of RMCP II, whereas both CCK-33 and gastrin induced a significant decrease in mast cell activity.	Sincalide	0-5	mast cell protease 2	Rattus norvegicus	35-42
12057766-2	2002	AIMS: In the present experiments, we examined the effects of a HSP coinducer drug-candidate, BRX-220, on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis in rats.	Sincalide	109-136	selenoprotein K	Rattus norvegicus	63-66
12057766-2	2002	AIMS: In the present experiments, we examined the effects of a HSP coinducer drug-candidate, BRX-220, on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis in rats.	Sincalide	109-136	cholecystokinin	Rattus norvegicus	138-141
11897495-4	2002	Similar to CCK-8, ROS generated by the oxidation of hypoxanthine (HX) with xanthine oxidase (XOD) induced an initial decrease in actin filaments located under the apical membrane followed by a smaller increase in the content of actin filaments in the subapical area.	Sincalide	11-16	xanthine dehydrogenase	Mus musculus	75-91
11833090-0	2002	CCK-8 inhibits expression of TNF-alpha in the spleen of endotoxic shock rats and signal transduction mechanism of p38 MAPK.	Sincalide	0-5	tumor necrosis factor	Rattus norvegicus	29-38
11833090-7	2002	CCK-8 significantly inhibited the LPS-induced increase of TNF-alpha content in spleen.	Sincalide	0-5	tumor necrosis factor	Rattus norvegicus	58-67
11755115-1	2001	In the present study we have employed fura-2 loaded isolated mouse pancreatic acinar cells to monitor the effect that xanthine oxidase (XOD)-catalyzed reactive oxygen species generation presents on Ca(2+) mobilization by the secretagogue cholecystokinin octapeptide (CCK-8).	Sincalide	238-265	xanthine dehydrogenase	Mus musculus	136-139
11755115-5	2001	However, reactive oxygen species had no effect either on Ca(2+) extrusion or on re-uptake into intracellular stores, but CCK-8-evoked Ca(2+) entry was reduced by XOD.	Sincalide	121-126	xanthine dehydrogenase	Mus musculus	162-165
11755115-6	2001	In conclusion, our results show that XOD-evoked reactive oxygen species generation leads to a reduction either of Ca(2+) mobilization, following stimulation of pancreatic acinar cells with the Ca(2+)-mobilizing agonists CCK-8 and acetylcholine, and Ca(2+) influx evoked by CCK-8 depletion of intracellular stores.	Sincalide	220-225	xanthine dehydrogenase	Mus musculus	37-40
11719968-2	2001	The aim of this study was to investigate the potential effects of HSP preinduction by cold- (CWI) or hot-water immersion (HWI) on pro-inflammatory cytokine production (IL-1, IL-6, TNF-alpha) in cholecystokinin-octapeptide(CCK)-induced acute pancreatitis.	Sincalide	194-221	tumor necrosis factor	Rattus norvegicus	180-189
11231022-1	2001	Addition of gastrin or cholecystokinin octapeptide (CCK-8) to cultures of Rat-1 cells stably transfected with the CCK2 (CCK(B)/gastrin) receptor induced protein kinase D (PKD) activation that was detectable within 1 min and reached a maximum ( approximately 10-fold) after 2.5 min of hormonal stimulation.	Sincalide	23-50	gastrin	Rattus norvegicus	127-134
11819851-6	2001	CCK-8 significantly inhibited the LPS-induced increase in serum TNF-alpha IL-1beta and IL-6.	Sincalide	0-5	tumor necrosis factor	Rattus norvegicus	64-73
11819851-6	2001	CCK-8 significantly inhibited the LPS-induced increase in serum TNF-alpha IL-1beta and IL-6.	Sincalide	0-5	interleukin 1 beta	Rattus norvegicus	74-82
11819851-6	2001	CCK-8 significantly inhibited the LPS-induced increase in serum TNF-alpha IL-1beta and IL-6.	Sincalide	0-5	interleukin 6	Rattus norvegicus	87-91
11819851-9	2001	In the heart, CCK-8 significantly inhibited LPS-induced increase of TNF-alpha (864 +/- 123 ng.L(-1) in CCK-8+LPS group vs 1599 +/- 227 ng.L(-1) in LPS group, P < 0.01), and IL-1beta (282 +/- 93 ng.L(-1) in CCK-8+LPS group vs 621 +/- 145ng.L(-1) in LPS group, P < 0.01).	Sincalide	14-19	tumor necrosis factor	Rattus norvegicus	68-77
11819851-9	2001	In the heart, CCK-8 significantly inhibited LPS-induced increase of TNF-alpha (864 +/- 123 ng.L(-1) in CCK-8+LPS group vs 1599 +/- 227 ng.L(-1) in LPS group, P < 0.01), and IL-1beta (282 +/- 93 ng.L(-1) in CCK-8+LPS group vs 621 +/- 145ng.L(-1) in LPS group, P < 0.01).	Sincalide	14-19	interleukin 1 beta	Rattus norvegicus	176-184
10678088-6	1999	CCK-A receptor antagonist devazepide (10 nmol.L-1) reversed the antagonism of sincalide to the effect of morphine.	Sincalide	78-87	cholecystokinin A receptor	Rattus norvegicus	0-14
10898764-2	2000	Initial contraction induced by agonists (CCK-8 and neuromedin C) was abolished by 1) inhibitors of Ca(2+) mobilization (neomycin and dimethyleicosadienoic acid), 2) calmidazolium, and 3) myosin light chain (MLC) kinase (MLCK) inhibitor KT-5926.	Sincalide	41-46	myosin light chain kinase 3	Homo sapiens	187-218
10898764-2	2000	Initial contraction induced by agonists (CCK-8 and neuromedin C) was abolished by 1) inhibitors of Ca(2+) mobilization (neomycin and dimethyleicosadienoic acid), 2) calmidazolium, and 3) myosin light chain (MLC) kinase (MLCK) inhibitor KT-5926.	Sincalide	41-46	myosin light chain kinase 3	Homo sapiens	220-224
10694507-5	2000	Glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and vasoactive intestinal polypeptide (VIP) diminished CCK-8-induced efflux.	Sincalide	126-131	glucagon	Rattus norvegicus	0-23
10694507-5	2000	Glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and vasoactive intestinal polypeptide (VIP) diminished CCK-8-induced efflux.	Sincalide	126-131	glucagon	Rattus norvegicus	25-30
10694507-5	2000	Glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and vasoactive intestinal polypeptide (VIP) diminished CCK-8-induced efflux.	Sincalide	126-131	vasoactive intestinal peptide	Rattus norvegicus	75-108
10694507-5	2000	Glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and vasoactive intestinal polypeptide (VIP) diminished CCK-8-induced efflux.	Sincalide	126-131	vasoactive intestinal peptide	Rattus norvegicus	110-113
10409110-4	1999	CCK-8-induced IkappaB-alpha degradation was maximal within 1 h. Expression of mob-1 was maximal within 2 h. Neither bombesin nor carbachol significantly increased mob-1 mRNA or induced IkappaB-alpha degradation.	Sincalide	0-5	NFKB inhibitor alpha	Homo sapiens	14-27
10595478-0	1999	Effect of atropine and sincalide on the intestinal uptake of F-18 fluorodeoxyglucose.	Sincalide	23-32	mastermind like domain containing 1	Homo sapiens	61-65
10678088-8	1999	The antagonistic effect of sincalide on morphine was mainly mediated by CCK-A receptor.	Sincalide	27-36	cholecystokinin A receptor	Rattus norvegicus	72-86
10461364-4	1998	When tested in COS-7 cells transiently expressing the recombinant human CCK-BR, saturating concentrations of the small "peptoid" ligands PD 135,158 and PD 136,450 stimulated inositol phosphate formation to 23 and 43 percent, respectively, of the maximum response induced by a considerably larger endogenous peptide agonist, cholecystokinin octapeptide.	Sincalide	324-351	cholecystokinin B receptor	Homo sapiens	72-78
10389118-0	1999	Intraperitoneal, but not subcutaneous, administration of the sulphated cholecystokinin octapeptide (CCK-8S) inhibits operant and nonoperant food intake in rats: implications for the CCK-satiety hypothesis.	Sincalide	71-98	cholecystokinin	Rattus norvegicus	100-103
10389118-0	1999	Intraperitoneal, but not subcutaneous, administration of the sulphated cholecystokinin octapeptide (CCK-8S) inhibits operant and nonoperant food intake in rats: implications for the CCK-satiety hypothesis.	Sincalide	71-98	cholecystokinin	Rattus norvegicus	182-185
11324560-3	1998	The CCK-8 effect, again, could be suppressed by CCK-A receptor antagonist devazepide (10 nmol/L), but partially by CCK-B receptor antagonist L-365, 260 at 10 nmol/L or completely at concentration of 30 nmol/L.	Sincalide	4-9	cholecystokinin A receptor	Rattus norvegicus	48-62
11324560-3	1998	The CCK-8 effect, again, could be suppressed by CCK-A receptor antagonist devazepide (10 nmol/L), but partially by CCK-B receptor antagonist L-365, 260 at 10 nmol/L or completely at concentration of 30 nmol/L.	Sincalide	4-9	cholecystokinin B receptor	Rattus norvegicus	115-129
9662718-1	1998	Recent reports have shown that estradiol increases the hypophagic effect of exogenous cholecystokinin-octapeptide (CCK).	Sincalide	86-113	cholecystokinin	Rattus norvegicus	115-118
11819361-3	1998	CCK-8 could antagonize the effects of morphine, i.e. th SPA and SPN were increased again, followed by the increase of CA.	Sincalide	0-5	surfactant protein A1	Rattus norvegicus	56-59
11819361-4	1998	On the basis of the above, CCK-A receptor antagonist Devazepide could reverse the antagonism of CCK-8 to the effect of morphine.CONCLUSION:CCK-8 could antagonize the effect of morphine which inhibited the potentiation of ACh on the duodenal activities in vitro.Furthermore, it was inferred that the antagonistic effect of CCK-8 on morphine was mainly mediated by CCK-A receptor.	Sincalide	96-101	cholecystokinin A receptor	Rattus norvegicus	27-41
11819361-4	1998	On the basis of the above, CCK-A receptor antagonist Devazepide could reverse the antagonism of CCK-8 to the effect of morphine.CONCLUSION:CCK-8 could antagonize the effect of morphine which inhibited the potentiation of ACh on the duodenal activities in vitro.Furthermore, it was inferred that the antagonistic effect of CCK-8 on morphine was mainly mediated by CCK-A receptor.	Sincalide	96-101	cholecystokinin A receptor	Rattus norvegicus	363-377
11819361-4	1998	On the basis of the above, CCK-A receptor antagonist Devazepide could reverse the antagonism of CCK-8 to the effect of morphine.CONCLUSION:CCK-8 could antagonize the effect of morphine which inhibited the potentiation of ACh on the duodenal activities in vitro.Furthermore, it was inferred that the antagonistic effect of CCK-8 on morphine was mainly mediated by CCK-A receptor.	Sincalide	139-144	cholecystokinin A receptor	Rattus norvegicus	27-41
11819361-4	1998	On the basis of the above, CCK-A receptor antagonist Devazepide could reverse the antagonism of CCK-8 to the effect of morphine.CONCLUSION:CCK-8 could antagonize the effect of morphine which inhibited the potentiation of ACh on the duodenal activities in vitro.Furthermore, it was inferred that the antagonistic effect of CCK-8 on morphine was mainly mediated by CCK-A receptor.	Sincalide	139-144	cholecystokinin A receptor	Rattus norvegicus	363-377
11819361-4	1998	On the basis of the above, CCK-A receptor antagonist Devazepide could reverse the antagonism of CCK-8 to the effect of morphine.CONCLUSION:CCK-8 could antagonize the effect of morphine which inhibited the potentiation of ACh on the duodenal activities in vitro.Furthermore, it was inferred that the antagonistic effect of CCK-8 on morphine was mainly mediated by CCK-A receptor.	Sincalide	139-144	cholecystokinin A receptor	Rattus norvegicus	27-41
11819361-4	1998	On the basis of the above, CCK-A receptor antagonist Devazepide could reverse the antagonism of CCK-8 to the effect of morphine.CONCLUSION:CCK-8 could antagonize the effect of morphine which inhibited the potentiation of ACh on the duodenal activities in vitro.Furthermore, it was inferred that the antagonistic effect of CCK-8 on morphine was mainly mediated by CCK-A receptor.	Sincalide	139-144	cholecystokinin A receptor	Rattus norvegicus	363-377
9586964-5	1998	These results show that bFGF inhibits CCK-8-induced pancreatic response by a tyrosine kinase-dependent mechanism.	Sincalide	38-43	fibroblast growth factor 2	Rattus norvegicus	24-28
9570471-4	1998	Gliquidone also increased the rate of pepsinogen release in gastric glands incubated either under basal conditions or in the presence of cholecystokinin-octapeptide or isoproterenol.	Sincalide	137-164	pepsin II-2/3	Oryctolagus cuniculus	38-48
9586964-2	1998	Our data show that bFGF inhibited CCK-8-induced amylase release in a concentration-dependent manner and decreased the CCK-8-induced rise in [Ca2+]i.	Sincalide	34-39	fibroblast growth factor 2	Rattus norvegicus	19-23
9586964-2	1998	Our data show that bFGF inhibited CCK-8-induced amylase release in a concentration-dependent manner and decreased the CCK-8-induced rise in [Ca2+]i.	Sincalide	118-123	fibroblast growth factor 2	Rattus norvegicus	19-23
9277417-0	1997	CCK-8 infusion increases plasma LMW alkaline phosphatase coincident with enterohepatic circulation of bile acids.	Sincalide	0-5	alkaline phosphatase, biomineralization associated	Canis lupus familiaris	36-56
9341915-3	1997	As CCK-A antagonist, this compound inhibits the CCK-8-evoked amylase release from pancreatic acinar cells at a low concentration, similar to that of the typical antagonist Devazepide.	Sincalide	48-53	cholecystokinin A receptor	Homo sapiens	3-8
9496716-1	1998	The sulphated form of cholecystokinin-octapeptide (CCK-OP) induces a concentration-dependent relaxation of the circular muscle of isolated chicken ileum which is unaffected by atropine or propranolol but abolished by tetrodotoxin (TTX).	Sincalide	22-49	cholecystokinin	Gallus gallus	51-54
9334884-3	1997	At higher concentrations, CCK-8 induced a single biphasic [Ca2+]i rise consisting of a large peak followed by a lower sustained plateau, while the response turned into [Ca2+]i oscillation when the extracellular Ca2+ was eliminated or a PLA2 inhibitor was included.	Sincalide	26-31	phospholipase A2 group IB	Homo sapiens	236-240
9218635-2	1997	A GTP analogue guanylyl-imidodiphosphate (GMP-PNP) at 100 microM markedly increased the K(d) values of the [3H]NPA binding sites in the rat forebrain sections, and coincubation with CCK-8 (1 nM) again did not produce a further increase in the K(d) values.	Sincalide	182-187	purine nucleoside phosphorylase	Rattus norvegicus	46-49
9368919-4	1997	CCK-8 increased the weight of the pancreas and its contents of DNA, protein, trypsinogen, chymotrypsinogen, proelastase, secretory trypsin inhibitor and amylase, but not that of lipase when given for 6 months, whereas administration of secretin + CCK-8 doubled the pancreatic content of lipase and increased all trophic parameters (except the amylase content) over those of CCK-8-treated rats.	Sincalide	0-5	lipase G, endothelial type	Rattus norvegicus	287-293
8740941-7	1996	treatment with CCK-8, the daily rhythm of the vasopressin and oxytocin release was similar to daily rhythm in the control group; respective figures were, however, reduced for the hypothalamus and neurohypophysis as well as increased for the blood plasma.	Sincalide	15-20	arginine vasopressin	Rattus norvegicus	46-57
9174069-5	1997	CCK-8-induced suppression was completely abolished by (+)L-365,260, a selective CCK(B) receptor antagonist, but not by (-)L-364,718, a selective CCK(A) receptor antagonist.	Sincalide	0-5	cholecystokinin B receptor	Rattus norvegicus	80-95
8565746-4	1996	When the isolated acini were incubated with 1 x 10(-10) M cholecystokinin octapeptide (CCK-8) that induced the maximal stimulation, the amount of Rab11 p24 increased in the fractions of plasma membrane and zymogen granules, but decreased in the cytosol fraction.	Sincalide	58-85	RAB11a, member RAS oncogene family	Rattus norvegicus	146-151
9328227-1	1997	Smooth muscle cells isolated from the caecal circular smooth muscle layers of the guinea pig were used to determine whether adrenomedullin and guanylin can inhibit the contractile response produced by 10(-9) M cholecystokinin octapeptide (CCK-8).	Sincalide	210-237	ADM	Cavia porcellus	124-138
8886024-2	1996	CCK-8 dose-dependently increased Src kinase activities by a mechanism that was sensitive to herbimycin A.	Sincalide	0-5	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	33-36
8769867-3	1996	In the present study, two different experiments were performed to test the hypothesis that G alpha q/11 mediates CCK-8 enhancement of the cationic conductance.	Sincalide	113-118	G protein subunit alpha q	Rattus norvegicus	91-100
8769867-6	1996	G alpha q and G alpha 11 mRNAs were present in all substantia nigra dopaminergic neurons that responded to CCK-8.	Sincalide	107-112	G protein subunit alpha q	Rattus norvegicus	0-9
8769867-6	1996	G alpha q and G alpha 11 mRNAs were present in all substantia nigra dopaminergic neurons that responded to CCK-8.	Sincalide	107-112	G protein subunit alpha 11	Rattus norvegicus	14-24
8769867-9	1996	Our studies suggest that CCK-8 activation of the cationic conductance in substantia nigra dopaminergic neurons is transduced by G alpha q and/or G alpha 11.	Sincalide	25-30	G protein subunit alpha q	Rattus norvegicus	128-137
8769867-9	1996	Our studies suggest that CCK-8 activation of the cationic conductance in substantia nigra dopaminergic neurons is transduced by G alpha q and/or G alpha 11.	Sincalide	25-30	G protein subunit alpha 11	Rattus norvegicus	145-155
9208565-8	1995	The results indicate that CCK-8 stimulate prolactin release at both sites of hypothalamic and anterior pituitary and the mechanism of stimulating effects of CCK-8 might be mediated by [Ca2+] but not cAMP.	Sincalide	26-31	prolactin	Rattus norvegicus	42-51
8750713-3	1995	[Leu11]gastrin-(5-17), CCK-8 and cionin were found to induce [14C]aminopyrine accumulation to 25% above the basal level.	Sincalide	23-28	gastrin	Oryctolagus cuniculus	7-14
8750713-9	1995	[Leu11]gastrin-(5-17)- or CCK-8-induced [14C]aminopyrine accumulation was inhibited by about 40% by the histamine H2 receptor blocker cimetidine.	Sincalide	26-31	histamine H2 receptor	Oryctolagus cuniculus	104-125
8531095-5	1995	The effect of CCK-8 can in turn be abolished by the CCK-B receptor antagonist L365,260.	Sincalide	14-19	cholecystokinin B receptor	Rattus norvegicus	52-66
8554722-1	1995	Abdominal vagotomy markedly reduces or abolishes the inhibitory effect of cholecystokinin (CCK-8) on meal size.	Sincalide	91-96	cholecystokinin	Rattus norvegicus	74-89
7936110-1	1994	Systemic treatment with cholecystokinin octapeptide (CCK-8, 2.5-10 micrograms/kg, s.c.), a non-selective CCK agonist, decreased the exploratory activity of mice in an elevated plus-maze.	Sincalide	24-51	cholecystokinin	Mus musculus	53-56
7729645-6	1995	CCK-8-stimulated pancreatic protein output was inhibited by PP in the dorsal motor nucleus in dose-dependent and site-specific manners.	Sincalide	0-5	pancreatic polypeptide	Rattus norvegicus	60-62
7729645-7	1995	The inhibitory effect of PP on CCK-8-stimulated protein output was eliminated by vagotomy.	Sincalide	31-36	pancreatic polypeptide	Rattus norvegicus	25-27
7597912-7	1995	The inhibition of synaptosomal 45Ca uptake induced by SCH or sincalide was blocked by beta-endorphin.	Sincalide	61-70	pro-opiomelanocortin-alpha	Mus musculus	86-100
7724827-5	1995	These results suggest that CCK-8 is a negative modulator of several macrophage functions, and that the inhibition of these activities is carried out through an increase of intracellular cAMP levels and a decrease in PKC activity.	Sincalide	27-32	cathelicidin antimicrobial peptide	Mus musculus	186-190
7524341-6	1994	Cholecystokinin octapeptide (CCK-8) and EDRab3AL had additive effects on the acinar Ins(1,4,5)P3 level.	Sincalide	0-27	cholecystokinin	Homo sapiens	29-32
8564259-2	1995	Cholecystokinin octapeptide (CCK-8) and gastrin-17 augment gastric mucosal blood flow in the rat.	Sincalide	0-27	cholecystokinin	Rattus norvegicus	29-32
8549438-4	1995	Stimulated biliary drainage was obtained following intraduodenal infusion of magnesium sulfate or intravenous sincalide, a CCK analogue.	Sincalide	110-119	cholecystokinin	Homo sapiens	123-126
7563961-3	1995	Unexpectedly, VIP inhibited CCK-8-induced intracellular Ca2+ oscillations.	Sincalide	28-33	VIP peptides	Cavia porcellus	14-17
7563961-8	1995	These results suggest that VIP, in spite of its inhibitory action on Ca2+ oscillations, facilitates a Ca(2+)-dependent process distal to the increase in [Ca2+]c to potentiate CCK-8-induced amylase release.	Sincalide	175-180	VIP peptides	Cavia porcellus	27-30
7717068-4	1994	The results indicated that 0.1 mumol.L-1 sincalide induced c-fos expression markedly in both brain (a 3.8-fold increase in c-fos protein level) and in spinal dorsal horn (a 3.6-fold increase).	Sincalide	41-50	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-64
7717068-4	1994	The results indicated that 0.1 mumol.L-1 sincalide induced c-fos expression markedly in both brain (a 3.8-fold increase in c-fos protein level) and in spinal dorsal horn (a 3.6-fold increase).	Sincalide	41-50	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	123-128
7717068-8	1994	In contrast, the effect of sincalide on c-fos protein production is antagonistic to that of Ohm.	Sincalide	27-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	40-45
7936110-1	1994	Systemic treatment with cholecystokinin octapeptide (CCK-8, 2.5-10 micrograms/kg, s.c.), a non-selective CCK agonist, decreased the exploratory activity of mice in an elevated plus-maze.	Sincalide	24-51	cholecystokinin	Mus musculus	105-108
7517089-5	1994	Moreover, EGF (17 nM) inhibited bombesin-, carbachol-, and CCK-8-induced 1,4,5-IP3-production at five seconds after beginning of the incubation by 81 +/- 19%, 65 +/- 15%, and 60 +/- 12%, respectively.	Sincalide	59-64	epidermal growth factor like 1	Rattus norvegicus	10-13
7520502-1	1994	Cholecystokinin-octapeptide (CCK-OP) induces a time- and dose-dependent decrease of gap junctional conductance in isolated pairs of pancreatic acinar cells.	Sincalide	0-27	cholecystokinin	Homo sapiens	29-32
7916446-7	1994	In conclusion, using monoclonal anti-B-50 IgGs we established a causal relationship between B-50 and Ca(2+)-induced NA and CCK-8 release.	Sincalide	123-128	growth associated protein 43	Homo sapiens	37-41
7916446-7	1994	In conclusion, using monoclonal anti-B-50 IgGs we established a causal relationship between B-50 and Ca(2+)-induced NA and CCK-8 release.	Sincalide	123-128	growth associated protein 43	Homo sapiens	92-96
8058194-6	1994	CCK-8-evoked cationic current was antagonized by lorglumide, a selective CCK-A receptor antagonist.	Sincalide	0-5	cholecystokinin A receptor	Rattus norvegicus	73-87
8010038-2	1993	Sincalide (CCK-8) evoked guinea pig isolated ileum contraction at 10(-5)-10(-1) mumol.L-1 in a concentration-dependent manner, EC50 being 207 pmol.L-1.	Sincalide	0-9	cholecystokinin	Rattus norvegicus	11-14
7912604-5	1994	The inhibitory effect of somatostatin on secretin-induced pepsinogen secretion was abolished by pretreatment with pertussis toxin, but inhibition of forskolin-, carbachol- and cholecystokinin octapeptide-induced pepsinogen secretion was not.	Sincalide	176-203	somatostatin	Homo sapiens	25-37
7513126-2	1994	L-365,260 and PD-135,666 inhibited gastrin- and CCK-8-stimulated HDC activity with a high potency [50% inhibitory concentration (IC50) 1.00 +/- 0.08 and 4.2 +/- 0.7 nM for gastrin-stimulated and 1.95 +/- 0.21 and 1.78 +/- 0.12 nM for CCK-8-stimulated HDC activity, respectively], whereas L-364,718 was 50 to 100 times less potent (EC50 100 +/- 2.5 and 91.2 +/- 3.1 nM, respectively on gastrin- and CCK-8-stimulated HDC activity).	Sincalide	48-53	histidine decarboxylase	Oryctolagus cuniculus	65-68
7513126-2	1994	L-365,260 and PD-135,666 inhibited gastrin- and CCK-8-stimulated HDC activity with a high potency [50% inhibitory concentration (IC50) 1.00 +/- 0.08 and 4.2 +/- 0.7 nM for gastrin-stimulated and 1.95 +/- 0.21 and 1.78 +/- 0.12 nM for CCK-8-stimulated HDC activity, respectively], whereas L-364,718 was 50 to 100 times less potent (EC50 100 +/- 2.5 and 91.2 +/- 3.1 nM, respectively on gastrin- and CCK-8-stimulated HDC activity).	Sincalide	48-53	gastrin	Oryctolagus cuniculus	172-179
7513126-2	1994	L-365,260 and PD-135,666 inhibited gastrin- and CCK-8-stimulated HDC activity with a high potency [50% inhibitory concentration (IC50) 1.00 +/- 0.08 and 4.2 +/- 0.7 nM for gastrin-stimulated and 1.95 +/- 0.21 and 1.78 +/- 0.12 nM for CCK-8-stimulated HDC activity, respectively], whereas L-364,718 was 50 to 100 times less potent (EC50 100 +/- 2.5 and 91.2 +/- 3.1 nM, respectively on gastrin- and CCK-8-stimulated HDC activity).	Sincalide	48-53	histidine decarboxylase	Oryctolagus cuniculus	251-254
7513126-2	1994	L-365,260 and PD-135,666 inhibited gastrin- and CCK-8-stimulated HDC activity with a high potency [50% inhibitory concentration (IC50) 1.00 +/- 0.08 and 4.2 +/- 0.7 nM for gastrin-stimulated and 1.95 +/- 0.21 and 1.78 +/- 0.12 nM for CCK-8-stimulated HDC activity, respectively], whereas L-364,718 was 50 to 100 times less potent (EC50 100 +/- 2.5 and 91.2 +/- 3.1 nM, respectively on gastrin- and CCK-8-stimulated HDC activity).	Sincalide	48-53	gastrin	Oryctolagus cuniculus	172-179
7513126-2	1994	L-365,260 and PD-135,666 inhibited gastrin- and CCK-8-stimulated HDC activity with a high potency [50% inhibitory concentration (IC50) 1.00 +/- 0.08 and 4.2 +/- 0.7 nM for gastrin-stimulated and 1.95 +/- 0.21 and 1.78 +/- 0.12 nM for CCK-8-stimulated HDC activity, respectively], whereas L-364,718 was 50 to 100 times less potent (EC50 100 +/- 2.5 and 91.2 +/- 3.1 nM, respectively on gastrin- and CCK-8-stimulated HDC activity).	Sincalide	48-53	histidine decarboxylase	Oryctolagus cuniculus	251-254
8146670-0	1993	[Cholecystokinin octapeptide (CCK-8) antagonizes morphine analgesia in amygdala of the rat].	Sincalide	1-28	cholecystokinin	Rattus norvegicus	30-33
8099887-9	1993	CONCLUSIONS: Our data indicates that CGRP inhibits pancreatic enzyme secretion evoked by 2DG or CCK-8 via vagal pathways.	Sincalide	96-101	calcitonin-related polypeptide alpha	Rattus norvegicus	37-41
8103634-8	1993	These findings indicate that somatostatin inhibits 2-deoxy-D-glucose- and CCK-8-evoked pancreatic enzyme secretion via a vagal pathway.	Sincalide	74-79	somatostatin	Rattus norvegicus	29-41
8106077-6	1993	Somatostatin did not inhibit carbachol- or CCK-8-induced [Ca2+]i increase, but did inhibit carbachol- and CCK-8-induced pepsinogen secretion by 30 and 50%, respectively.	Sincalide	106-111	somatostatin	Homo sapiens	0-12
8342693-3	1993	These findings support the hypothesis that CCK-8 induced c-fos expression is mediated by CCK-A receptors.	Sincalide	43-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-62
8221136-1	1993	Systemic administration of CCK-8 increased plasma oxytocin (OXT) level in rats anesthetized with a mixture of urethane and alpha-chloralose.	Sincalide	27-32	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	50-58
7681836-7	1993	In COS-7 cells expressing the cloned receptor, CCK-8-stimulated phosphatidylinositol hydrolysis and intracellular Ca2+ mobilization suggesting second messenger signaling through phospholipase C. CCK-B/gastrin receptor transcripts were identified in human brain, stomach, and pancreas using high stringency Northern blot analysis.	Sincalide	47-52	cholecystokinin B receptor	Homo sapiens	195-200
7681836-7	1993	In COS-7 cells expressing the cloned receptor, CCK-8-stimulated phosphatidylinositol hydrolysis and intracellular Ca2+ mobilization suggesting second messenger signaling through phospholipase C. CCK-B/gastrin receptor transcripts were identified in human brain, stomach, and pancreas using high stringency Northern blot analysis.	Sincalide	47-52	cholecystokinin B receptor	Homo sapiens	201-217
8361969-3	1993	Following intravenous infusion of cholecystokinin octapeptide (CCK-8; 200 pmol/kg/h) for 60 min, the concentration of intestinal enterostatin increased from a basal level of 2.0 +/- 0.7 microM to 5.64 +/- 1.1 microM at time point 60 min.	Sincalide	34-61	cholecystokinin	Rattus norvegicus	63-66
7685159-1	1993	In this study we report that a synthetic peptide of the effector domain of rab3A (rab3AL(33-48)) stimulates both amylase secretion and inositol 1,4,5-trisphosphate (IP3)-accumulation in digitonin-permeabilized pancreatic acini in an analogous way to cholecystokinin-octapeptide (CCK8).	Sincalide	250-277	RAB3A, member RAS oncogene family	Homo sapiens	75-80
8221136-1	1993	Systemic administration of CCK-8 increased plasma oxytocin (OXT) level in rats anesthetized with a mixture of urethane and alpha-chloralose.	Sincalide	27-32	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	60-63
8221136-3	1993	Thirteen out of 16 nonphasic neurons (putative OXT-secreting neurons) were excited by intravenous and/or intraperitoneal administration of CCK-8.	Sincalide	139-144	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	47-50
8221136-4	1993	By contrast, 8 out of 10 phasic cells, vasopressin(AVP)-secreting cells, were inhibited by systemic administration of CCK-8.	Sincalide	118-123	arginine vasopressin	Rattus norvegicus	39-50
8221136-9	1993	These results suggest that CCK-8 activates the excitatory afferent pathway to putative OXT-secreting neurons in the PVN which may, at least in part, be involved in the central noradrenergic projection.	Sincalide	27-32	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	87-90
1507652-4	1992	Intracerebroventricular continuous infusion of cholecystokinin octapeptide (CCK8) following BF lesion obviously preserved these cholinergic markers.	Sincalide	76-80	cholecystokinin	Rattus norvegicus	47-62
1511338-4	1992	The effects of CCK-8, epinephrine and naloxone showed a differential ability to block amnesia induced by beta-endorphin intraventricularly with epinephrine and naloxone preventing amnesia but CCK-8 not improving retention.	Sincalide	15-20	pro-opiomelanocortin-alpha	Mus musculus	105-119
1351858-3	1992	During S-28 infusion, the output of lipase, trypsin, amylase, and bicarbonate stimulated by either exogenous cholecystokinin octapeptide or endogenous signals from intraduodenal administration of tryptophan or a mixture of amino acids was significantly reduced.	Sincalide	109-136	somatostatin	Homo sapiens	7-11
1797567-0	1991	CCK-8-related C-terminal tetrapeptides: affinities for central CCKB and peripheral CCKA receptors.	Sincalide	0-5	cholecystokinin B receptor	Homo sapiens	63-67
1373616-1	1992	In intact rat pancreatic acini, the phospholipase A2 inhibitor mepacrine did not affect basal amylase release but dose-dependently inhibited the carbachol (IC50 65 microM) and CCK-8 (IC50 210 microM)-stimulated amylase release.	Sincalide	176-181	phospholipase A2 group IB	Rattus norvegicus	36-52
1373616-3	1992	From these results we conclude that carbachol, CCK-8 and GTPrS probably activate a phospholipase A2 closely coupled to exocytosis.	Sincalide	47-52	phospholipase A2 group IB	Rattus norvegicus	83-99
1531470-7	1992	These findings indicate that the calmodulin messenger branch that is activated by a rise of intracellular Ca2+ mobilised in cytosol from its intracellular, but not extracellular, source plays a critical role in pepsinogen secretion induced by carbachol and CCK-8.	Sincalide	257-262	calmodulin	Oryctolagus cuniculus	33-43
1531470-7	1992	These findings indicate that the calmodulin messenger branch that is activated by a rise of intracellular Ca2+ mobilised in cytosol from its intracellular, but not extracellular, source plays a critical role in pepsinogen secretion induced by carbachol and CCK-8.	Sincalide	257-262	pepsin II-2/3	Oryctolagus cuniculus	211-221
1640799-3	1992	Implantation of morphine pellets (400 mg) in male guinea pigs depressed cholecystokinin-octapeptide(CCK)-induced emptying of gallbladder bile (monitored via a duodenal cannula).	Sincalide	72-99	cholecystokinin	Cavia porcellus	100-103
1724566-3	1991	As with VIP, these actions are potentiated by adding an inhibitor of cyclic nucleotide phosphodiesterase, and combination of PACAP-38 with bombesin, CCK-8, carbachol or the calcium ionophore A23187 results in 2-fold augmentation of the secretory actions of these agents.	Sincalide	149-154	vasoactive intestinal peptide	Rattus norvegicus	8-11
1886889-5	1991	Furthermore, GLP-1(7-36) amide showed additive stimulatory influence with glucose (2.8 mmol/kg), the cholinergic agonist carbachol (0.16 mumol/kg), and the C-terminal octapeptide of cholecystokinin (CCK-8, 5.3 nmol/kg), when injected at 8 or 32 nmol/kg.	Sincalide	199-204	glucagon	Mus musculus	13-18
1654792-6	1991	Using a tyrosine-sulfated cholecystokinin octapeptide (CCK-8) as the ligand in a radioimmunoassay, it was found that the binding of the TyrS-binding protein was pH-dependent, being strong from pH 8.0 down through 6.5, and becoming dramatically weaker at pH below 6.0.	Sincalide	26-53	tyrosyl-tRNA synthetase 1	Bos taurus	136-140
1788334-0	1991	Antinociceptive and gastrointestinal transit effects of cholecystokinin (CCK-8) and related analogs of CCK-8 in the mouse.	Sincalide	73-78	cholecystokinin	Mus musculus	56-71
1996638-8	1991	These results demonstrate that gastrin and CCK-8 interact with the same "gastrin-type" receptor on parietal cells.	Sincalide	43-48	gastrin	Oryctolagus cuniculus	73-80
1994383-5	1991	PP and PYY significantly inhibited secretin/CCK-8-induced pancreatic exocrine secretion.	Sincalide	44-49	pancreatic polypeptide	Canis lupus familiaris	0-2
1994383-5	1991	PP and PYY significantly inhibited secretin/CCK-8-induced pancreatic exocrine secretion.	Sincalide	44-49	peptide YY	Canis lupus familiaris	7-10
2050197-3	1991	injections of cholecystokinin octapeptide sulphated (CCK) in the mouse were examined using selective CCKA and CCKB receptor antagonists.	Sincalide	14-41	cholecystokinin	Mus musculus	53-56
2365002-1	1990	The effects of tifluadom, a benzodiazepine-kappa-opioid-receptor agonist, on cholecystokinin-octapeptide (CCK-8)-induced antinociception were investigated in the mouse writhing test.	Sincalide	77-104	cholecystokinin	Mus musculus	106-109
1712842-4	1990	Cholecystokinin octapeptide (CCK8; 0.10-6.40 nmol (kg body weight)-1) induced dose-dependent increases in pancreatic juice flow, total protein output and amylase release in the anaesthetized rat.	Sincalide	0-27	Body weight QTL 17	Rattus norvegicus	59-68
2183285-2	1990	To evaluate this hypothesis, sincalide, a cholecystokinin derivative, was administered to 15 fasting trauma patients who had undergone laparotomy.	Sincalide	29-38	cholecystokinin	Homo sapiens	42-57
2322595-1	1990	In dispersed gastric chief cells from guinea-pig stomach, binding of iodinated cholecystokinin octapeptide (125I-CCK-8) was relatively slow, temperature-dependent, to a single class of binding sites and inhibited by various gastrin- and CCK-related agonists and receptor antagonists.	Sincalide	79-106	cholecystokinin	Homo sapiens	113-116
2322595-1	1990	In dispersed gastric chief cells from guinea-pig stomach, binding of iodinated cholecystokinin octapeptide (125I-CCK-8) was relatively slow, temperature-dependent, to a single class of binding sites and inhibited by various gastrin- and CCK-related agonists and receptor antagonists.	Sincalide	79-106	gastrin	Cavia porcellus	224-232
2322595-1	1990	In dispersed gastric chief cells from guinea-pig stomach, binding of iodinated cholecystokinin octapeptide (125I-CCK-8) was relatively slow, temperature-dependent, to a single class of binding sites and inhibited by various gastrin- and CCK-related agonists and receptor antagonists.	Sincalide	79-106	cholecystokinin	Cavia porcellus	237-240
34477002-3	2021	The effects of miR-2682-5p on the viability, migration, and apoptosis of NSCLC cells were detected by CCK-8, Transwell, and flow cytometry assays.	Sincalide	102-107	microRNA 2682	Homo sapiens	15-23
2111914-9	1990	CCK-8 seems to modulate the action of haloperidol through altering the sensitivity of dopamine, opioid, GABA-A and benzodiazepine receptors.	Sincalide	0-5	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	104-110
2326499-3	1990	PYY opposed the action of CCK-8 to a greater extent than that of nicotine and transmural electrical stimulation.	Sincalide	26-31	peptide YY	Canis lupus familiaris	0-3
33941557-11	2021	Western blotting was used to detect the expression of PLAC1 under hypoxic conditions, and the cell viability and apoptosis of trophoblast cells in a low oxygen concentration after overexpression of PLAC1 were detected by CCK-8 and flow cytometry assay.	Sincalide	221-226	placenta enriched 1	Homo sapiens	198-203
34748768-8	2021	Intrathecal administration of the MEK inhibitor blocked somatic sensitization caused by the CCK receptor agonist CCK8.	Sincalide	113-117	cholecystokinin	Rattus norvegicus	92-95
34687906-4	2022	CCK-8 was used to determine the optimal concentration of the Piezo1 agonist, Yoda1.	Sincalide	0-5	piezo type mechanosensitive ion channel component 1	Homo sapiens	61-67
34338153-6	2021	The effects of miR-409 on the abilities of proliferation, migration and invasion were detected by CCK-8 and Transwell.	Sincalide	98-103	microRNA 409	Homo sapiens	15-22
34774067-6	2021	CCK-8 and colony formation assays demonstrated that STOML2 silencing inhibited cell proliferation in MM cells.	Sincalide	0-5	stomatin like 2	Homo sapiens	52-58
34510848-13	2021	CONCLUSIONS: Based on these findings, it may be concluded that the molecular mechanisms participating in CCK-8-induced pharmacological preconditioning involve HIF-1alpha, PI3K, Akt, and GSK-3beta signaling pathways.	Sincalide	105-110	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	159-169
34510848-13	2021	CONCLUSIONS: Based on these findings, it may be concluded that the molecular mechanisms participating in CCK-8-induced pharmacological preconditioning involve HIF-1alpha, PI3K, Akt, and GSK-3beta signaling pathways.	Sincalide	105-110	AKT serine/threonine kinase 1	Rattus norvegicus	177-180
34510848-9	2021	RESULTS: Pharmacological preconditioning with CCK-8 reduced IR-induced increases in the release of LDH, CK-MB and cTnT.	Sincalide	46-51	lactate dehydrogenase A	Rattus norvegicus	99-102
34510848-9	2021	RESULTS: Pharmacological preconditioning with CCK-8 reduced IR-induced increases in the release of LDH, CK-MB and cTnT.	Sincalide	46-51	troponin T2, cardiac type	Rattus norvegicus	114-118
34510848-13	2021	CONCLUSIONS: Based on these findings, it may be concluded that the molecular mechanisms participating in CCK-8-induced pharmacological preconditioning involve HIF-1alpha, PI3K, Akt, and GSK-3beta signaling pathways.	Sincalide	105-110	glycogen synthase kinase 3 alpha	Rattus norvegicus	186-195
34475767-12	2021	CCK-8 and Annexin V/PI apoptosis assays demonstrated that Daam1 overexpression decreased cisplatin sensitivity and downregulated cisplatin-induced apoptosis.	Sincalide	0-5	dishevelled associated activator of morphogenesis 1	Homo sapiens	58-63
34402181-2	2021	Cholecystokinin octapeptide (CCK-8), an immunomodulatory peptide, regulates memory and learning.	Sincalide	29-34	cholecystokinin	Mus musculus	0-15
34402181-9	2021	RESULTS: Administration of CCK-8 suppressed the activation of microglia, the induction of A1 reactive astrocytes, and the expression of tumor necrosis factor alpha, complement 1q, and interleukin 1 alpha in the hippocampus.	Sincalide	27-32	tumor necrosis factor	Mus musculus	136-163
34402181-9	2021	RESULTS: Administration of CCK-8 suppressed the activation of microglia, the induction of A1 reactive astrocytes, and the expression of tumor necrosis factor alpha, complement 1q, and interleukin 1 alpha in the hippocampus.	Sincalide	27-32	interleukin 1 alpha	Mus musculus	184-203
34568013-6	2021	Gain-of- and loss-of-function experiments were performed to detect the biological functions of SLC25A21 in vitro and in vivo by CCK-8 assay, plate colony formation assay, cell migration, invasion assay and experimental animal models.	Sincalide	128-133	solute carrier family 25 member 21	Homo sapiens	95-103
34119916-5	2021	The effect of Gem and Talpha1 on cell viability, proliferation, apoptosis, autophagy was detected by CCK-8, colony formation, flow cytometry, autophagic flux measurement, respectively.	Sincalide	101-106	trace amine associated receptor 1	Homo sapiens	22-29
34522186-4	2021	CCK-8, crystal violet and Transwell assays were used to determine cell proliferation, colony formation, migration, and invasion of HCC cell lines in which PRMT4 was overexpressed or downregulated.	Sincalide	0-5	coactivator associated arginine methyltransferase 1	Homo sapiens	155-160
34418280-6	2021	The transfection experiments were employed to measure the effect of FAM66C on cell viabilities, migration, and invasion in ICC cells by CCK-8, transwell assays.	Sincalide	136-141	family with sequence similarity 66 member C	Homo sapiens	68-74
34692376-3	2021	CCK-8 was used to investigate the effect of nsPEFs on the viability of TPC-1 cells.	Sincalide	0-5	two pore segment channel 1	Homo sapiens	71-76
34429761-5	2021	The effects of HDAC1 on cellular proliferation, apoptosis, migration, invasiveness and tumorigenesis were determined by CCK-8, flow cytometry, wound-healing, transwell chamber and in vivo tumor formation experiments, respectively.	Sincalide	120-125	histone deacetylase 1	Homo sapiens	15-20
34627452-2	2021	METHODS: Different concentrations of recombinant human HMGB1 protein (100, 200, 400, 800 and 1000 ng/ml) were incubated with MSC for 24, 48, 72 h and the proliferation of MSC were detected respectively by using the CCK-8 method and flow cytometry.	Sincalide	215-220	high mobility group box 1	Homo sapiens	55-60
34604387-3	2021	CCK-8 method was used to detect the effect of S100A8 and S100A9 on the viability of nasopharyngeal carcinoma cells.	Sincalide	0-5	S100 calcium binding protein A8	Homo sapiens	46-52
34604387-3	2021	CCK-8 method was used to detect the effect of S100A8 and S100A9 on the viability of nasopharyngeal carcinoma cells.	Sincalide	0-5	S100 calcium binding protein A9	Homo sapiens	57-63
34496838-5	2021	The biological functions of LINC00958 were detected by CCK-8, MTT, colony formation and flow cytometric analyses.	Sincalide	55-60	long intergenic non-protein coding RNA 958	Homo sapiens	28-37
34175738-10	2021	After overexpressing P2RY12, the proliferation and migration of A549 cells was detected by CCK-8 and scratch test.	Sincalide	91-96	purinergic receptor P2Y12	Homo sapiens	21-27
34091388-6	2021	The effects of LINC00665 on cell proliferation, invasion, metastasis, and cell cycle in GC were evaluated using the CCK-8, wound healing, Transwell, and flow cytometry assays.	Sincalide	116-121	long intergenic non-protein coding RNA 665	Homo sapiens	15-24
34184962-5	2021	CCK-8 and colony formation assays indicated that the silencing of RPN2 reduced the proliferation and growth of 5-8F and CNE1 cells.	Sincalide	0-5	ribophorin II	Homo sapiens	66-70
34516949-9	2021	Uptake of (3H)-cholecystokinin octapeptide (CCK-8), a specific OATP1B3 substrate, was determined.	Sincalide	44-49	solute carrier organic anion transporter family member 1B3	Homo sapiens	63-70
34094932-6	2021	The effects of HOXA13 on sensitivity of GC cells to 5-FU were investigated by Cell Counting Kit-8 (CCK-8), 5-Ethynyl-2"-deoxyuridine (EdU) incorporation, flow cytometry and experiment in vivo.	Sincalide	99-104	homeobox A13	Homo sapiens	15-21
34097426-4	2021	The effects of USP9X on cell cisplatin resistance, proliferation, apoptosis, and metastasis were examined by CCK-8 assay, flow cytometry, wound-healing assay, and Transwell chamber assay.	Sincalide	109-114	ubiquitin specific peptidase 9 X-linked	Homo sapiens	15-20
34516949-13	2021	(3H)-CCK-8 accumulation in cells+BC was significantly greater (~5-13 folds, p<0.001) in day 4 SCH with vs. without Ad-OATP1B3-transduction.	Sincalide	5-10	solute carrier organic anion transporter family member 1B3	Homo sapiens	118-125
35235125-5	2022	After the suppression of circWHSC1 expression, the changes in the proliferation, migration, invasion, and apoptosis capacities were detected by CCK-8 assay, colony formation assay, Transwell assays, flow cytometry, and the determination of apoptosis-related proteins.	Sincalide	144-149	nuclear receptor binding SET domain protein 2	Homo sapiens	25-34
35562411-5	2022	The impacts of miR-148a-5p, CREB1, FoxO1, and SRGN on NPC cell viability, proliferation, migration, and invasion were estimated in vitro by CCK-8, colony formation, wound healing and Transwell experiments, and in vivo by a xenograft tumor model.	Sincalide	140-145	serglycin	Homo sapiens	46-50
35609331-5	2022	The effects of PCAT6 knockdown on the viability and apoptosis in NSCLC cells were detected with CCK-8 and flow cytometry assay.	Sincalide	96-101	prostate cancer associated transcript 6	Homo sapiens	15-20
35509083-5	2022	The function of CYP2E1 were detected by CCK-8, wound healing, transwell assays, xenograft models and pulmonary metastasis model.	Sincalide	40-45	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	16-22
35432529-3	2022	The effects of KCNQ1OT1 on the proliferation of PA cells, namely, GH3 and HP75, were detected by CCK-8 experiment.	Sincalide	97-102	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	15-23
35429143-5	2022	We then investigated the effect of increased activation of cGAS-STING pathway on the proliferation of H460 and A549 cells by CCK-8 and colony formation assays, and revealed the underlying mechanism.	Sincalide	125-130	cyclic GMP-AMP synthase	Homo sapiens	59-63
35421944-8	2022	The effect of SNCA on proliferation of A549 cells were evaluated by CCK-8, EdU and colony formation.	Sincalide	68-73	synuclein alpha	Homo sapiens	14-18
35432540-5	2022	A GNL3 interfering plasmid was constructed, and the effects of GNL3 on the proliferation of HepG2 and PLC-PRF-5 hepatoma cells were detected by the CCK-8 method.	Sincalide	148-153	G protein nucleolar 3	Homo sapiens	63-67
35184456-9	2022	The absorbance value of Sh-miR1290 group detected by the CCK-8 method and the colony formation rate detected by the colony formation experiment were both increased, the number of cells penetrating the basement membrane in the Transwell experiment and the wound healing rate in the scratch experiment were decreased (P<0.05).	Sincalide	57-62	microRNA 1290	Homo sapiens	27-34
2655616-3	1989	Preincubation of permeabilized cells with activated cholera toxin (CT) inhibited cholecystokinin-octapeptide (CCK-OP) and GTP-gamma-S--but not Cch-induced production of IP3.	Sincalide	81-108	cholecystokinin	Rattus norvegicus	110-113
35096061-11	2022	The effect of LTF overexpression on proliferation, migration, and invasion of MG63 and 143B cells was detected by the CCK-8 assay, transwell cell migration assay, and transwell invasion assay, respectively.	Sincalide	118-123	lactotransferrin	Homo sapiens	14-17
35069734-6	2022	Then, detailed functional effects of an acidic environment on miR-451a and MEF2D in PANC-1 cells were detected by CCK-8, colony formation, flow cytometry, wound healing, transwell, mitochondrial functionality measurement, JC-1 staining, DCFH-DA staining, and sphere formation assays.	Sincalide	114-119	microRNA 451a	Mus musculus	62-70
2557925-2	1989	Both gastrin and CCK-8 (octapeptide of cholecystokinin) stimulated [14C]aminopyrine (AP) uptake by cells (EC50 0.07 +/- 0.03 nM (gastrin) and 0.093 +/- 0.065 nM (CCK-8] and increased [3H]inositol phosphates cellular contents (EC50 0.142 +/- 0.016 nM (gastrin) and 0.116 +/- 0.027 nM (CCK-8] in a parallel fashion.	Sincalide	17-22	gastrin	Oryctolagus cuniculus	129-136
2557925-2	1989	Both gastrin and CCK-8 (octapeptide of cholecystokinin) stimulated [14C]aminopyrine (AP) uptake by cells (EC50 0.07 +/- 0.03 nM (gastrin) and 0.093 +/- 0.065 nM (CCK-8] and increased [3H]inositol phosphates cellular contents (EC50 0.142 +/- 0.016 nM (gastrin) and 0.116 +/- 0.027 nM (CCK-8] in a parallel fashion.	Sincalide	17-22	gastrin	Oryctolagus cuniculus	129-136
2695319-7	1989	CCK-8-induced insulin but not PP release.	Sincalide	0-5	insulin	Canis lupus familiaris	14-21
35056756-7	2022	We also verified the effects of miR-126-5p on cell proliferation, migration, and invasion by cck-8, cell colony formation and trans-well assay in both HCCLM3 cells and HepG2 cells.	Sincalide	93-98	microRNA 126	Homo sapiens	32-39
2475031-5	1989	CCK-8- and forskolin- but not substance P-evoked release of [3H]ACh were maximally inhibited in the presence of 10(-6) M somatostatin (49 +/- 5 and 48 +/- 7% of control, respectively).	Sincalide	0-5	somatostatin	Cavia porcellus	121-133
2475031-6	1989	Pretreatment with pertussis toxin (inactivates inhibitory guanine nucleotide binding proteins) reversed the inhibitory effect of somatostatin on the release of [3H]ACh evoked by CCK-8.	Sincalide	178-183	somatostatin	Cavia porcellus	129-141
2475031-8	1989	Somatostatin appears to inhibit the cAMP-dependent component of CCK-8-mediated cholinergic transmission via activation of a pertussis toxin-sensitive G protein.	Sincalide	64-69	somatostatin	Cavia porcellus	0-12
2602948-0	1989	[Antagonism of morphine analgesia and electroacupuncture analgesia by cholecystokinin octapeptide (CCK-8) administered in periaqueductal gray (PAG) of the rabbits].	Sincalide	70-97	cholecystokinin	Oryctolagus cuniculus	99-102
3306623-1	1987	Cholecystokinin octapeptide (CCK-8, 1, 190 pmol/5 min) decreased food intake and water consumption in two models of ingestive behavior, i.e., food deprivation-induced feeding and insulin-induced feeding, when administered into the third (3V) and lateral (LV) cerebral ventricles.	Sincalide	0-27	insulin	Canis lupus familiaris	179-186
2451868-3	1988	CCK-8-stimulated amylase and lipase secretion were less sensitive to the noxious effect of cyclosporine being impaired at a dose of 10 mg/kg.	Sincalide	0-5	lipase G, endothelial type	Rattus norvegicus	29-35
2474070-5	1988	Acetylcholine (ACh, 0.05-0.5 microM) and cholecystokinin octapeptide (CCK-8, 10-50 pM) concomitantly induced transient increases in cell membrane current, capacitance and conductance only when cytosolic Ca2+ was weakly chelated by EGTA (70 microM).	Sincalide	41-68	cholecystokinin	Rattus norvegicus	70-73
2467329-1	1988	Administration of cholecystokinin octapeptide (CCK-8) intravenously, or in the subarachnoidal surface of the olfactory lobe in rats, caused an increase in pancreatic protein and amylase secretion.	Sincalide	18-45	cholecystokinin	Rattus norvegicus	47-50
2901360-2	1988	A two-week treatment with either diazepam (5 mg/kg per day) or flurazepam (15 mg/kg per day) markedly reduced the excitatory effect of microiontophoretically applied sulphated cholecystokinin octapeptide-(26-33) on rat CA3 hippocampal pyramidal neurons but not that of acetylcholine.	Sincalide	176-203	carbonic anhydrase 3	Rattus norvegicus	219-222
3377080-1	1988	Cholecystokinin octapeptide (CCK-8)-induced contraction and [3H]acetylcholine ([3H]-ACh) release from the longitudinal muscle strip of the guinea pig common bile duct were studied by a standard organ bath method and superfusion system.	Sincalide	29-34	cholecystokinin	Cavia porcellus	0-15
2896352-6	1988	At the lowest concentration of CGRP (10(-11) M), the inhibitory effect of CGRP on CCK-8-stimulated release of insulin was statistically significant (p less than 0.05) and exceptionally potent (65-90% inhibition).	Sincalide	82-87	calcitonin-related polypeptide alpha	Rattus norvegicus	31-35
2896352-6	1988	At the lowest concentration of CGRP (10(-11) M), the inhibitory effect of CGRP on CCK-8-stimulated release of insulin was statistically significant (p less than 0.05) and exceptionally potent (65-90% inhibition).	Sincalide	82-87	calcitonin-related polypeptide alpha	Rattus norvegicus	74-78
3297634-3	1987	Proglumide (0.2 mg/kg, iv) and benzotript (0.2 mg/kg, iv), specific CCK receptor antagonists, blocked the icv CCK-8-induced increase in plasma PRL levels.	Sincalide	110-115	prolactin	Rattus norvegicus	143-146
4018718-5	1985	Addition of 10(-3) M verapamil to the incubation medium inhibited CCK-8-induced PRL release from the cells.	Sincalide	66-71	prolactin	Rattus norvegicus	80-83
3591942-4	1987	All animals received 20 min of intravenous infusion of cholecystokinin octapeptide (CCK-OP), 2.5 ng X kg-1 X min-1, immediately followed by 60-min infusions of either lactated Ringer (LR) or synthetic PYY, 10 or 50 ng X kg-1 X min-1.	Sincalide	55-82	cholecystokinin	Canis lupus familiaris	84-87
3295578-1	1987	Cholecystokinin octapeptide (CCK 8) produced significant antinociception in the tail immersion test in the rat, paw pressure test in the rat and acetylcholine-induced writhing test in the mouse after subcutaneous (s.c.) administration.	Sincalide	0-27	cholecystokinin	Rattus norvegicus	29-32
2876416-2	1986	NPY in a dose-dependent manner also reduced the neurally-mediated excitatory effect of cholecystokinin octapeptide (CCK8) sulfated form on this preparation.	Sincalide	87-114	pro-neuropeptide Y	Cavia porcellus	0-3
3953805-5	1986	Diversion of pancreaticobiliary juice resulted in a threefold increase in pancreatic protein output and an increase of plasma cholecystokinin from a basal level of 0.5 +/- 0.08 pM cholecystokinin octapeptide (CCK-8) to 16 +/- 4 pM CCK-8.	Sincalide	209-214	cholecystokinin	Rattus norvegicus	126-141
2875206-1	1985	Cholecystokinin-octapeptide (CCK-OP) evoked contraction and 3H-acetylcholine (3H-ACh) release of the muscle strip of the guinea pig gallbladder were studied.	Sincalide	0-27	cholecystokinin	Cavia porcellus	29-32
2420205-6	1986	Equipotent, maximally effective contractile doses of CCK-8, acetylcholine, and methionine-enkephalin caused equivalent degrees of net Ca2+ efflux.	Sincalide	53-58	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	134-137
3949282-0	1986	CCK-8 antagonizes apomorphine-induced growth hormone secretion in normal subjects.	Sincalide	0-5	growth hormone 1	Homo sapiens	38-52
3949282-1	1986	Cholecystokinin octapeptide (CCK-8) (5 ug iv over 10 minutes) administered to normal men had no effect on basal growth hormone (GH) or prolactin secretion but significantly antagonized the GH response to the dopamine (DA) receptor agonist, apomorphine HCI (Apo) (0.5 mg sc), 30 (P less than 0.05) and 45 minutes (P less than 0.01) after Apo injection (n = 8).	Sincalide	0-27	growth hormone 1	Homo sapiens	189-191
6151935-5	1984	Addition of 10(-3)M verapamil to the incubation medium inhibited CCK-8-induced GH release from the cells.	Sincalide	65-70	gonadotropin releasing hormone receptor	Rattus norvegicus	79-81
2986058-1	1985	Peptidases present in central nervous system (CNS) synaptic membranes, hydrolyze the neuroactive peptide cholecystokinin-octapeptide (CCK-8; Asp-Tyr-SO3H-Met-Gly-Trp-Met-Asp-Phe-NH2).	Sincalide	141-181	cholecystokinin	Homo sapiens	105-120
2986058-1	1985	Peptidases present in central nervous system (CNS) synaptic membranes, hydrolyze the neuroactive peptide cholecystokinin-octapeptide (CCK-8; Asp-Tyr-SO3H-Met-Gly-Trp-Met-Asp-Phe-NH2).	Sincalide	141-181	cholecystokinin	Homo sapiens	134-137
3990827-2	1985	Direct administration of cholecystokinin octapeptide (CCK-8) (20-60 ng) into the preoptic anterior hypothalamic area caused a dose-related fall in rectal temperature at ambient temperatures of 8 degrees C and 22 degrees C. The hypothermia induced by CCK-8 was produced by a decrease in metabolism at an ambient temperature of 8 degrees C, whereas at 22 degrees C, it was caused by both a decrease in metabolism and an increase in cutaneous temperature.	Sincalide	54-59	cholecystokinin	Rattus norvegicus	25-40
3990827-2	1985	Direct administration of cholecystokinin octapeptide (CCK-8) (20-60 ng) into the preoptic anterior hypothalamic area caused a dose-related fall in rectal temperature at ambient temperatures of 8 degrees C and 22 degrees C. The hypothermia induced by CCK-8 was produced by a decrease in metabolism at an ambient temperature of 8 degrees C, whereas at 22 degrees C, it was caused by both a decrease in metabolism and an increase in cutaneous temperature.	Sincalide	250-255	cholecystokinin	Rattus norvegicus	25-40
3995287-1	1985	Intracerebroventricularly applied cholecystokinin-8-sulfate (CCK-8) induced a significant and dose-related increase in gastric acid output in urethane anesthetized rats.	Sincalide	61-66	cholecystokinin	Rattus norvegicus	34-49
4080707-3	1985	The results indicate that VIP antagonizes the effects of CCK-8 on spontaneous motility and rearing, and the effects are more apparent in the decorticated rats.	Sincalide	57-62	vasoactive intestinal peptide	Rattus norvegicus	26-29
6083815-6	1984	Cholecystokinin-octapeptide (38 nM) induced a large increase in the release of somatostatin but only a minute increase in the release of substance P; these effects of cholecystokinin-octapeptide were not blocked by tetrodotoxin (1.3 microM).	Sincalide	0-27	somatostatin	Cavia porcellus	79-91
6092811-6	1984	Further, the inhibitory effect of cholecystokinin-octapeptide (CCK8) on cell-associated 125I-EGF radioactivity was significantly greater in diabetic than in normal rat acini.	Sincalide	34-61	epidermal growth factor like 1	Rattus norvegicus	93-96
6322784-1	1984	The binding of 125I-labeled insulin-like growth factor II (125I-IGF II) to mouse pancreatic acini was stimulated (45%) by insulin and inhibited (30%) by cholecystokinin octapeptide (CCK8).	Sincalide	153-180	insulin-like growth factor 2	Mus musculus	64-70
6316193-1	1983	Intraperitoneal administration of cholecystokinin octapeptide sulphate ester (CCK-8-SE) and nonsulphated cholecystokinin octapeptide (CCK-8-NS) enhanced the latency of seizures induced by picrotoxin in mice.	Sincalide	34-61	cholecystokinin	Mus musculus	78-81
6321698-2	1984	In this study, the effect of cholecystokinin-octapeptide (CCK-8) on basal and electrically evoked tritium outflow from slices of cat caudate nucleus previously labeled with [3H]dopamine was examined.	Sincalide	29-56	cholecystokinin	Homo sapiens	58-61
6274669-2	1981	administration of cholecystokinin octapeptide (CCK-8) appeared to suppress the effects of L-DOPA and antagonize the actions of thyrotropin-releasing hormone (TRH).	Sincalide	18-45	thyrotropin releasing hormone	Rattus norvegicus	127-156
6305211-1	1983	Extracellular unitary recordings were made from neurons in the rat dorsal vagal nucleus, and the response of these neurons to iontophoretically applied cholecystokinin octapeptide (CCK-OP) and proglumide (a novel CCK antagonist) was studied.	Sincalide	152-179	cholecystokinin	Rattus norvegicus	181-184
6281507-4	1982	injection of thyrotropin releasing hormone (TRH) shortened the sleeping time and the effect of CCK-8 was apparently antagonized by combined administration of TRH.	Sincalide	95-100	thyrotropin releasing hormone	Rattus norvegicus	13-42
6281507-4	1982	injection of thyrotropin releasing hormone (TRH) shortened the sleeping time and the effect of CCK-8 was apparently antagonized by combined administration of TRH.	Sincalide	95-100	thyrotropin releasing hormone	Rattus norvegicus	44-47
6281507-4	1982	injection of thyrotropin releasing hormone (TRH) shortened the sleeping time and the effect of CCK-8 was apparently antagonized by combined administration of TRH.	Sincalide	95-100	thyrotropin releasing hormone	Rattus norvegicus	158-161
6281507-9	1982	These results indicate that CCK-8 has a sedative action and antagonizes the behavioral excitation caused by TRH and methamphetamine, but that the effects of CCK-8-NS and caerulein were rather the opposite of those of CCK-8.	Sincalide	28-33	thyrotropin releasing hormone	Rattus norvegicus	108-111
6294391-3	1982	Moreover, the suppressive effect of beta-endorphin on TRH-induced body shakes was antagonized by simultaneous administration of caerulein and CCK-8.	Sincalide	142-147	thyrotropin releasing hormone	Rattus norvegicus	54-57
6297314-2	1983	Cholecystokinin octapeptide (CCK-OP) stimulated pepsinogen secretion with an ED50 of about 1 nM.	Sincalide	0-27	cholecystokinin	Oryctolagus cuniculus	29-32
6297314-2	1983	Cholecystokinin octapeptide (CCK-OP) stimulated pepsinogen secretion with an ED50 of about 1 nM.	Sincalide	0-27	pepsin II-2/3	Oryctolagus cuniculus	48-58
6294698-6	1982	The weak effect of CCK-8 following ventricular administration is additional evidence suggesting that cholecystokinin of intestinal origin acts in the periphery rather than directly on the brain to elicit its typically rapid satiety effect in rats.	Sincalide	19-24	cholecystokinin	Rattus norvegicus	101-116
6285318-1	1982	Cholecystokinin octapeptide (CCK-OP) was reported to decrease the intake of liquid food in lean and in obese man.	Sincalide	0-27	cholecystokinin	Homo sapiens	29-32
6281503-2	1982	However, the serotonin-potentiating effect of TRH was apparently suppressed by simultaneous administration of CCK-8.	Sincalide	110-115	thyrotropin releasing hormone	Rattus norvegicus	46-49
6274669-2	1981	administration of cholecystokinin octapeptide (CCK-8) appeared to suppress the effects of L-DOPA and antagonize the actions of thyrotropin-releasing hormone (TRH).	Sincalide	18-45	thyrotropin releasing hormone	Rattus norvegicus	158-161
6274669-2	1981	administration of cholecystokinin octapeptide (CCK-8) appeared to suppress the effects of L-DOPA and antagonize the actions of thyrotropin-releasing hormone (TRH).	Sincalide	47-52	thyrotropin releasing hormone	Rattus norvegicus	127-156
6274669-2	1981	administration of cholecystokinin octapeptide (CCK-8) appeared to suppress the effects of L-DOPA and antagonize the actions of thyrotropin-releasing hormone (TRH).	Sincalide	47-52	thyrotropin releasing hormone	Rattus norvegicus	158-161
7014327-1	1981	There are now a large number of experiments demonstrating that peripheral administration of exogenous cholecystokinin or its synthetic analogue, CCK-8, reduces meal size in a number of species.	Sincalide	145-150	cholecystokinin	Rattus norvegicus	102-117
27942816-1	1981	There are now a large number of experiments demonstrating that peripheral administration of exogenous cholecystokinin or its synthetic analogue, CCK-8, reduces meal size in a number of species.	Sincalide	145-150	cholecystokinin	Rattus norvegicus	102-117
6260615-8	1981	Pentagastrin, sincalide and caerulein induced a slight but significant hypocalcaemia and a rise of serum CT levels, together with a significant increase of serum PTH.	Sincalide	14-23	parathyroid hormone	Homo sapiens	162-165
33616025-5	2021	Effects of Reelin on the proliferation of OPCs was measured by EdU and CCK-8.	Sincalide	71-76	reelin	Homo sapiens	11-17
6258973-1	1981	Cholecystokinin-octapeptide (CCK-8) was shown to cause hypothermia after intracerebroventricular administration in the rat, and the hypothermic effect of CCK-8 was antagonized by simultaneous injection of TRH.	Sincalide	29-34	cholecystokinin	Rattus norvegicus	0-15
6258973-1	1981	Cholecystokinin-octapeptide (CCK-8) was shown to cause hypothermia after intracerebroventricular administration in the rat, and the hypothermic effect of CCK-8 was antagonized by simultaneous injection of TRH.	Sincalide	29-34	thyrotropin releasing hormone	Rattus norvegicus	205-208
6258973-1	1981	Cholecystokinin-octapeptide (CCK-8) was shown to cause hypothermia after intracerebroventricular administration in the rat, and the hypothermic effect of CCK-8 was antagonized by simultaneous injection of TRH.	Sincalide	154-159	cholecystokinin	Rattus norvegicus	0-15
6258973-1	1981	Cholecystokinin-octapeptide (CCK-8) was shown to cause hypothermia after intracerebroventricular administration in the rat, and the hypothermic effect of CCK-8 was antagonized by simultaneous injection of TRH.	Sincalide	154-159	thyrotropin releasing hormone	Rattus norvegicus	205-208
835702-4	1977	Recordings were made in the fasted state, during the intravenous infusion of either saline or cholecystokinin-octapeptide (CCK-OP), during the intraduodenal infusion of either saline or L-tryptophan, and during the fed state.	Sincalide	94-121	cholecystokinin	Canis lupus familiaris	123-126
6264407-1	1980	Cholecystokinin octapeptide (CCK-OP) is a potent and specific suppressor of feeding when administered as a continuous lateral cerebral ventricular injection in fasted sheep, and we have proposed that endogenous CCK-OP in the brain is released during meals and acts to terminate feeding.	Sincalide	0-27	cholecystokinin	Ovis aries	29-32
6264407-1	1980	Cholecystokinin octapeptide (CCK-OP) is a potent and specific suppressor of feeding when administered as a continuous lateral cerebral ventricular injection in fasted sheep, and we have proposed that endogenous CCK-OP in the brain is released during meals and acts to terminate feeding.	Sincalide	0-27	cholecystokinin	Ovis aries	211-214
33085068-7	2021	CCK-8 was used to detect the effect of TUG1 on the proliferation of BV2 cells.	Sincalide	0-5	taurine upregulated gene 1	Mus musculus	39-43
33831787-1	2021	Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo.	Sincalide	480-485	SERPINE1 mRNA binding protein 1	Homo sapiens	32-38
33831787-1	2021	Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo.	Sincalide	480-485	SERPINE1 mRNA binding protein 1	Homo sapiens	39-70
33831787-1	2021	Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo.	Sincalide	480-485	SERPINE1 mRNA binding protein 1	Homo sapiens	178-184
33831787-1	2021	Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo.	Sincalide	480-485	SERPINE1 mRNA binding protein 1	Homo sapiens	178-184
33831787-1	2021	Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo.	Sincalide	480-485	cadherin 1	Homo sapiens	331-341
33831787-1	2021	Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo.	Sincalide	480-485	vimentin	Homo sapiens	343-351
33831787-1	2021	Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo.	Sincalide	480-485	cadherin 2	Homo sapiens	357-367
33831787-1	2021	Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo.	Sincalide	480-485	SERPINE1 mRNA binding protein 1	Homo sapiens	178-184
33831787-1	2021	Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo.	Sincalide	480-485	SERPINE1 mRNA binding protein 1	Homo sapiens	178-184
33831787-1	2021	Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo.	Sincalide	480-485	SERPINE1 mRNA binding protein 1	Homo sapiens	178-184
34015762-5	2021	CCK-8 was used to detect the effect of lncRNA LOC100129620 on the proliferation of osteosarcoma cells.	Sincalide	0-5	PLPPR5 antisense RNA 1	Homo sapiens	46-58
33627540-2	2021	Here, the effect of ARG on cell viability was evaluated in PC-3M cells by CCK-8 assay.	Sincalide	74-79	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	20-23
33693958-6	2021	The effect of siRNA targeting ENC1 (si-ENC1) on the proliferation of A549 and H1299 cells was detected by CCK-8 assay at the indicated time points.	Sincalide	106-111	ectodermal-neural cortex 1	Homo sapiens	30-34
33693958-6	2021	The effect of siRNA targeting ENC1 (si-ENC1) on the proliferation of A549 and H1299 cells was detected by CCK-8 assay at the indicated time points.	Sincalide	106-111	ectodermal-neural cortex 1	Homo sapiens	36-43
33245890-5	2021	A CCK-8 assay, an EdU assay and Annexin V/PI staining indicated that BST-2 inhibition attenuated BAFF-enhanced proliferation and survival in both Raji cells and Daudi cells.	Sincalide	2-7	bone marrow stromal cell antigen 2	Homo sapiens	69-74
34007244-5	2021	In vitro, miR-6869-5p inhibited macrophage proliferation demonstrated by EdU and CCK-8 experiments.	Sincalide	81-86	microRNA 6869	Homo sapiens	10-18
33897778-4	2021	Cholecystokinin octapeptide (CCK-8) was employed to evaluate the cytotoxicity of alloimperatorin on HeLa, SiHa, and MS-751 cells.	Sincalide	29-34	cholecystokinin	Homo sapiens	0-15
33650331-6	2021	The CCK-8 was then applied to measure cytotoxicity in cells with miR-147a upregulation or STAT3 suppression under irradiation apoptosis changes were detected with flow cytometry.	Sincalide	4-9	microRNA 147a	Homo sapiens	65-73
33650331-6	2021	The CCK-8 was then applied to measure cytotoxicity in cells with miR-147a upregulation or STAT3 suppression under irradiation apoptosis changes were detected with flow cytometry.	Sincalide	4-9	signal transducer and activator of transcription 3	Homo sapiens	90-95
33179980-4	2021	The effects of SUMO1P3 on the proliferation, invasion and migration of SGC-7901 and MKN45 cells were detected by CCK-8, transwell and wound healing assay respectively, and the effects of SUMO1P3 on apoptosis and cycle progression of SGC-7901 and MKN45 cells were detected by flow cytometry.	Sincalide	113-118	SUMO1 pseudogene 3	Homo sapiens	15-22
33125134-6	2020	The effects of CCAT2 silencing on TC cell proliferation were detected by CCK-8 and colony formation assays.	Sincalide	73-78	colon cancer associated transcript 2	Homo sapiens	15-20
32878533-4	2020	MATERIALS AND METHODS: TNF-alpha-induced RA-derived fibroblast-like synoviocyte MH7A cells were incubated with ACR (0.1-2 mg/mL) for 24 h. The proliferation was tested using CCK-8 and colony formation assays.	Sincalide	174-179	tumor necrosis factor	Homo sapiens	23-32
30556880-4	2018	Subsequently, the proliferation of glioma cells transfected with miR-650 mimics was evaluated by cell counting kit-8 (CCK-8) and EDU (5-ethynyl-2"-deoxyuridine) assay, respectively.	Sincalide	118-123	microRNA 650	Homo sapiens	65-72
32572784-7	2020	The cell injury elicited by LPC via TRPA1 was confirmed by both CCK-8 and LDH cytotoxicity detection.	Sincalide	64-69	transient receptor potential cation channel subfamily A member 1	Homo sapiens	36-41
32901871-5	2020	In the present study, we demonstrated that shRNA-mediated CHK1 silencing suppressed cell proliferation and enhanced the cytotoxic effects of etoposide (VP16) in the chronic myeloid leukemia (CML) cell line K562 through the results of CCK-8, and comet assay.	Sincalide	234-239	checkpoint kinase 1	Homo sapiens	58-62
33061441-6	2020	The effect of TP53INP2 silencing on the proliferation, migration, and invasion of bladder cancer cells was investigated by CCK-8 detection kit and transwell assay.	Sincalide	123-128	tumor protein p53 inducible nuclear protein 2	Homo sapiens	14-22
32540374-6	2020	Secondly, The CCK-8 and apoptosis experiment results suggested that downregulated miR-760 promoted cell proliferation ability and suppressed apoptosis activity in KGN and SVOG cells.	Sincalide	14-19	microRNA 760	Homo sapiens	82-89
32554056-2	2020	Cholecystokinin octapeptide (CCK-8) is expressed in cardiomyocytes and plays an important role in cardiovascular regulation.	Sincalide	29-34	cholecystokinin	Rattus norvegicus	0-15
32798383-7	2020	CCK-8 was used to measure the proliferation inhibition effect of ADM on K562/ADM cells when DRAM1 was downregulated by siRNA.	Sincalide	0-5	DNA damage regulated autophagy modulator 1	Homo sapiens	92-97
32111658-2	2020	Sincalide is a peptide hormone product administered parenterally as an aid for diagnostic imaging of hepatobiliary conditions.	Sincalide	0-9	activation induced cytidine deaminase	Homo sapiens	71-74
32552939-4	2020	CCK-8 was used to detect the effect of MEIS1 and miR-425 on cell proliferation.	Sincalide	0-5	Meis homeobox 1	Homo sapiens	39-44
32552939-4	2020	CCK-8 was used to detect the effect of MEIS1 and miR-425 on cell proliferation.	Sincalide	0-5	microRNA 425	Homo sapiens	49-56
32146174-2	2020	CCK-8 results showed that with the increase of the concentration of Seleno-Chitosan and the prolongation of culture time, the inhibition on the proliferation of SPC-A-1 cells gradually increased, and the morphology of SPC-A-1 cells changed obviously.	Sincalide	0-5	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	161-168
32146174-2	2020	CCK-8 results showed that with the increase of the concentration of Seleno-Chitosan and the prolongation of culture time, the inhibition on the proliferation of SPC-A-1 cells gradually increased, and the morphology of SPC-A-1 cells changed obviously.	Sincalide	0-5	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	218-225
31990564-3	2020	We determined the interactions of 136 oral molecular excipients with BCRP in isolated membrane vesicles and identified 26 excipients as BCRP inhibitors with IC50 values less than 5 muM using 3H-cholecystokinin octapeptide (3H-CCK-8).	Sincalide	191-221	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	136-140
32309371-5	2020	The effect of FAP on cell proliferation was examined by CCK-8 assay.	Sincalide	56-61	fibroblast activation protein alpha	Homo sapiens	14-17
33176600-4	2020	Our data showed that C3aR and C5aR knockdown significantly inhibited the proliferation, migration and invasion of HCC cells using CCK-8, colony formation and transwell assays.	Sincalide	130-135	complement C3a receptor 1	Homo sapiens	21-25
33176600-4	2020	Our data showed that C3aR and C5aR knockdown significantly inhibited the proliferation, migration and invasion of HCC cells using CCK-8, colony formation and transwell assays.	Sincalide	130-135	complement C5a receptor 1	Homo sapiens	30-34
31545474-4	2019	CCK-8, colony formation, Transwell, and flow cytometry assays were used to demonstrate that NKAP knockdown significantly suppressed the proliferation and invasion of HCT116 and HT-29 cells, and also induced apoptosis and autophagy.	Sincalide	0-5	NFKB activating protein	Homo sapiens	92-96
31666602-11	2019	Our findings showed that, CCK-8 staining and EdU labeling revealed suppression of cell proliferation by Notch signaling activation after Jagged-1 treatment in chondrocytes.	Sincalide	26-31	jagged canonical Notch ligand 1	Rattus norvegicus	137-145
31484832-6	2019	NG electroporation with TRESK siRNA restored NG responsiveness to CCK-8 and leptin.	Sincalide	66-71	potassium two pore domain channel subfamily K member 18	Homo sapiens	24-29
31308730-7	2019	RVM microinjection of the CCK2 receptor agonist CCK-8 and intrathecal injection of the 5-HT2B receptor agonist BW723C86 both produced hyperalgesia in female rats after plantar incision, whereas the CCK2 receptor antagonist YM022, the 5-HT2B receptor antagonist RS127445, and the PKCgamma inhibitor C37H65N9O13 decreased the rats" sensitivity to the same stimulus.	Sincalide	48-53	cholecystokinin B receptor	Rattus norvegicus	26-39
30797554-6	2019	The impact of caspase 3 gene overexpression on the biological behavior of DC2.4 cells was determined by CCK-8, colony formation and apoptosis analysis.	Sincalide	104-109	caspase 3	Mus musculus	14-23
30571983-3	2019	We found that intraperitoneal NS CCK-8 (0.5 nmol/kg) increases Fos-LI in the DVC, the myenteric and the submucosal plexuses of the duodenum and the myenteric plexus of the jejunum.	Sincalide	33-38	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-66
30554864-7	2019	CCK-8 and colony formation assay revealed the inhibitory effect of HCP5 knockdown on cell proliferation.	Sincalide	0-5	HLA complex P5	Homo sapiens	67-71
30663574-6	2019	METHODS: EDCI/DMAP was chosen as a coupling agent for the coupling of CPT with substituted norcantharidin derivatives and CCK-8 method was used to test the cytotoxicity and intensity on human hepatoma cell line HepG2.	Sincalide	122-127	choline phosphotransferase 1	Homo sapiens	70-73
32720731-6	2020	Transfection of a miR-1225 mimic inhibited cell viability and proliferation as indicated by CCK-8 staining and MTT assay.	Sincalide	92-97	microRNA 1225	Homo sapiens	18-26
32933876-5	2021	The effect of ANLN on proliferation and cell cycle is detected by CCK-8, colony formation assay and flow cytometry.	Sincalide	66-71	anillin, actin binding protein	Homo sapiens	14-18
32445877-1	2020	Cholecystokinin octapeptide with sulfate (CCK-8 s) regulates feeding behavior and psychomotor activity.	Sincalide	0-27	cholecystokinin a	Danio rerio	42-47
32699194-7	2020	Combining DCA and CCK-8 caused a 4-fold increase in c-Fos activation.	Sincalide	18-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-57
32661473-7	2020	The proliferation rate of both control and HOXB-7-silenced cells induced by varying concentrations of L-OHP was detected by the CCK-8 assay, while the degree of apoptosis in the same cells induced by 60 microM L-OHP was detected by flow cytometry.	Sincalide	128-133	homeobox B7	Homo sapiens	43-49
30195770-6	2018	CCK-8 and 5-Ethynyl-2"-deoxyuridine (EDU) assays revealed that miR-663a stimulated cell proliferation and DNA synthesis of human SSCs.	Sincalide	0-5	microRNA 663a	Homo sapiens	63-71
29215701-9	2018	CCK-8 and colony formation assay unveiled that RMST could slow down the proliferation of TNBC cells to influence the tumor progression.	Sincalide	0-5	rhabdomyosarcoma 2 associated transcript	Homo sapiens	47-51
29778424-8	2018	NRAGE depletion also sensitized HGC-27 and MGC-803 cells to cisplatin, as shown by CCK-8 and Annexin V/propidium iodide analyses.	Sincalide	83-88	MAGE family member D1	Homo sapiens	0-5
29949166-15	2018	CCK-8 and colony formation assay demonstrated that the proliferation of MH7A cells was elevated after TNF-alpha treatment.	Sincalide	0-5	tumor necrosis factor	Homo sapiens	102-111
30317774-5	2018	CCK-8 assay was used to detect the effect of HULC on proliferation of hepatocellular carcinoma cells.	Sincalide	0-5	hepatocellular carcinoma up-regulated long non-coding RNA	Homo sapiens	45-49
29360461-11	2018	RESULTS: Human pancreatic tissues and dispersed pancreatic acini from control mice exposed to CCK-8 or ethanol plus CCK-8 were depleted of STX2.	Sincalide	94-99	syntaxin 2	Mus musculus	139-143
29360461-13	2018	Acini from STX2-KO mice had increased apical exocytosis after exposure to CCK-8, as well as increased basolateral exocytosis, which led to ectopic release of proteases.	Sincalide	74-79	syntaxin 2	Mus musculus	11-15
29360461-19	2018	Exposure of pancreatic tissues to CCK-8 or ethanol depletes acinar cells of STX2, increasing basolateral exocytosis and promoting autophagy induction, leading to activation of trypsinogen.	Sincalide	34-39	syntaxin 2	Mus musculus	76-80
26163001-15	2015	Finally, phosphorylation of JNK in the presence of CCK-8 or melatonin was also observed.	Sincalide	51-56	mitogen-activated protein kinase 8	Mus musculus	28-31
26037524-4	2015	The relative activity factors (RAFs) for OATP1B1 and OATP1B3 transporters were calculated from intrinsic clearances obtained by concentration dependent uptake experiments in human hepatocytes and HEK overexpressing cells: RAF1B1 using estrone-3-sulfate and pitavastatine clearances, and RAF1B3 using cholecystokinine octapeptide (CCK-8) clearances.	Sincalide	330-335	solute carrier organic anion transporter family member 1B1	Homo sapiens	41-48
26037524-4	2015	The relative activity factors (RAFs) for OATP1B1 and OATP1B3 transporters were calculated from intrinsic clearances obtained by concentration dependent uptake experiments in human hepatocytes and HEK overexpressing cells: RAF1B1 using estrone-3-sulfate and pitavastatine clearances, and RAF1B3 using cholecystokinine octapeptide (CCK-8) clearances.	Sincalide	330-335	solute carrier organic anion transporter family member 1B3	Homo sapiens	53-60
27832662-6	2016	The effects of exogenous IL-9 on the sulfated cholecystokinin octapeptide (CCK-8S)-evoked [Ca2+]i elevation were observed by confocal microscopy.	Sincalide	46-73	interleukin 9	Mus musculus	25-29
32262827-10	2015	The CCK-8 assay revealed that the SiO2@PAM composites possessed a non-cytotoxic and favorable response to the seeded cells in vitro.	Sincalide	4-9	peptidylglycine alpha-amidating monooxygenase	Mus musculus	39-42
26722506-6	2015	MiR-106 inhibitor was further transfected into human gastric carcinoma cells for further cell proliferation using CCK-8 approach.	Sincalide	114-119	microRNA 106a	Homo sapiens	0-7
25664004-4	2014	We found the SIRT1 activator (resveratrol RSV) contributed to the repression of viability and increase of senescence, which were rescued by SIRT1 inhibitor (nicotinamide NA) and SIRT1 depletion by CCK-8 assay and SA-beta-gal assay respectively.	Sincalide	197-202	sirtuin 1	Homo sapiens	13-18
25629941-4	2015	CCK-8 pretreatment attenuated METH (10mg/kg)-induced hyperthermia, the decrease of tyrosine hydroxylase (TH) and dopamine transporter (DAT) in the striatum, and TH in the substantia nigra.	Sincalide	0-5	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	113-133
25629941-4	2015	CCK-8 pretreatment attenuated METH (10mg/kg)-induced hyperthermia, the decrease of tyrosine hydroxylase (TH) and dopamine transporter (DAT) in the striatum, and TH in the substantia nigra.	Sincalide	0-5	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	135-138
25618019-5	2015	The proteins OATP1B1 and OATP1B3 were functionally characterized in stably transfected human embryonic kidney cells using [(3)H] labeled estrone 3-sulfate and [(3)H] labeled cholecystokinin octapeptide (CCK-8) as substrates, respectively.	Sincalide	174-201	solute carrier organic anion transporter family member 1B1	Homo sapiens	13-20
25618019-5	2015	The proteins OATP1B1 and OATP1B3 were functionally characterized in stably transfected human embryonic kidney cells using [(3)H] labeled estrone 3-sulfate and [(3)H] labeled cholecystokinin octapeptide (CCK-8) as substrates, respectively.	Sincalide	174-201	solute carrier organic anion transporter family member 1B3	Homo sapiens	25-32
24309294-2	2014	We have previously reported that CCK-8 significantly alleviated morphine-induced amnesia and reversed spine density decreases in the CA1 region of the hippocampus in morphine-treated animals.	Sincalide	33-38	carbonic anhydrase 1	Rattus norvegicus	133-136
24704498-6	2014	L-364,718 and LY-288,513, selective antagonists of CCK1R and CCK2R, respectively, suppressed the effects of CCK-8 on CD4(+) T cell subset-specific transcription factors.	Sincalide	108-113	cholecystokinin A receptor	Homo sapiens	51-56
24704498-6	2014	L-364,718 and LY-288,513, selective antagonists of CCK1R and CCK2R, respectively, suppressed the effects of CCK-8 on CD4(+) T cell subset-specific transcription factors.	Sincalide	108-113	cholecystokinin B receptor	Homo sapiens	61-66
24704498-6	2014	L-364,718 and LY-288,513, selective antagonists of CCK1R and CCK2R, respectively, suppressed the effects of CCK-8 on CD4(+) T cell subset-specific transcription factors.	Sincalide	108-113	CD4 molecule	Homo sapiens	117-120
23994230-11	2013	Our findings conclude spine density change in CA1 region of hippocampus may be the structural plasticity mechanism which is responsible for enhancing effect of CCK-8 on spatial reference memory.	Sincalide	160-165	carbonic anhydrase 1	Mus musculus	46-49
22897388-7	2012	We observed saturable uptake of typical substrates of NTCP and OATPs except for cholecystokinin octapeptide (OATP1B3-selective substrate), and Na(+)-dependent uptake of taurocholate was confirmed.	Sincalide	80-107	solute carrier organic anion transporter family member 1B3	Homo sapiens	109-116
23215050-8	2013	OATP1B3 V1 showed only modest transport activity toward cholecystokin-8 (CCK-8, a prototype OATP1B3 substrate) in contrast to OATP1B3 WT showing a markedly efficient uptake of CCK-8.	Sincalide	73-78	solute carrier organic anion transporter family member 1B3	Homo sapiens	0-7
23215050-8	2013	OATP1B3 V1 showed only modest transport activity toward cholecystokin-8 (CCK-8, a prototype OATP1B3 substrate) in contrast to OATP1B3 WT showing a markedly efficient uptake of CCK-8.	Sincalide	73-78	solute carrier organic anion transporter family member 1B3	Homo sapiens	92-99
23215050-8	2013	OATP1B3 V1 showed only modest transport activity toward cholecystokin-8 (CCK-8, a prototype OATP1B3 substrate) in contrast to OATP1B3 WT showing a markedly efficient uptake of CCK-8.	Sincalide	73-78	solute carrier organic anion transporter family member 1B3	Homo sapiens	92-99
23215050-8	2013	OATP1B3 V1 showed only modest transport activity toward cholecystokin-8 (CCK-8, a prototype OATP1B3 substrate) in contrast to OATP1B3 WT showing a markedly efficient uptake of CCK-8.	Sincalide	176-181	solute carrier organic anion transporter family member 1B3	Homo sapiens	0-7
23082789-6	2012	In SCHH, the uptake of CCK-8 and pravastatin was found to be associated with the expression of OATP1B3 and OATP1B1, respectively.	Sincalide	23-28	solute carrier organic anion transporter family member 1B3	Homo sapiens	95-102
23082789-6	2012	In SCHH, the uptake of CCK-8 and pravastatin was found to be associated with the expression of OATP1B3 and OATP1B1, respectively.	Sincalide	23-28	solute carrier organic anion transporter family member 1B1	Homo sapiens	107-114