PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34653511-2	2022	A mouse model of neonatal HI brain injury was established, and AG205, a specific antagonist of pgrmc1, was injected into the left lateral cerebral ventricle 1 h before HI.	AG205	63-68	progesterone receptor membrane component 1	Mus musculus	95-101
34970218-4	2021	Meanwhile, AG205, the specific inhibitor of PGRMC1 was also used for functional validation of PGRMC1.	AG205	11-16	progesterone receptor membrane component 1	Rattus norvegicus	44-50
34970218-9	2021	Furthermore, through PGRMC1-EGFR/GLP1R-PI3K-Akt pathway, knockdown or inhibition (by AG205) of PGRMC1 mimics, whereas its overexpression moderately alleviates CLZ-induced glucose disturbances.	AG205	85-90	progesterone receptor membrane component 1	Rattus norvegicus	21-27
34970218-9	2021	Furthermore, through PGRMC1-EGFR/GLP1R-PI3K-Akt pathway, knockdown or inhibition (by AG205) of PGRMC1 mimics, whereas its overexpression moderately alleviates CLZ-induced glucose disturbances.	AG205	85-90	epidermal growth factor receptor	Rattus norvegicus	28-32
34970218-9	2021	Furthermore, through PGRMC1-EGFR/GLP1R-PI3K-Akt pathway, knockdown or inhibition (by AG205) of PGRMC1 mimics, whereas its overexpression moderately alleviates CLZ-induced glucose disturbances.	AG205	85-90	glucagon-like peptide 1 receptor	Rattus norvegicus	33-38
34970218-9	2021	Furthermore, through PGRMC1-EGFR/GLP1R-PI3K-Akt pathway, knockdown or inhibition (by AG205) of PGRMC1 mimics, whereas its overexpression moderately alleviates CLZ-induced glucose disturbances.	AG205	85-90	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
34970218-9	2021	Furthermore, through PGRMC1-EGFR/GLP1R-PI3K-Akt pathway, knockdown or inhibition (by AG205) of PGRMC1 mimics, whereas its overexpression moderately alleviates CLZ-induced glucose disturbances.	AG205	85-90	progesterone receptor membrane component 1	Rattus norvegicus	95-101
26264726-8	2015	This enhancement can be blocked by the progesterone receptor membrane component 1 (PGRMC1) inhibitor AG205, or by the ADP scavenger apyrase and the cyclooxygenase inhibitor indomethacin.	AG205	101-106	progesterone receptor membrane component 1	Homo sapiens	39-81
29649418-5	2018	Similarly, treatment of denuded oocytes with a PGRMC1 inhibitor, AG205, blocked the gonadotropin-induced increase in plasma membrane mPRalpha levels and attenuated DHP induction of OM.	AG205	65-70	progesterone receptor membrane component 1	Danio rerio	47-53
29649418-5	2018	Similarly, treatment of denuded oocytes with a PGRMC1 inhibitor, AG205, blocked the gonadotropin-induced increase in plasma membrane mPRalpha levels and attenuated DHP induction of OM.	AG205	65-70	S100 calcium binding protein A6 (calcyclin)	Mus musculus	133-141
29649418-7	2018	Treatment with AG205 reversed the inhibitory effects of the Erbb2 inhibitors on OM and also inhibited insulin-like growth factor-1 induction of OM.	AG205	15-20	erb-b2 receptor tyrosine kinase 2	Danio rerio	60-65
29649418-7	2018	Treatment with AG205 reversed the inhibitory effects of the Erbb2 inhibitors on OM and also inhibited insulin-like growth factor-1 induction of OM.	AG205	15-20	insulin-like growth factor 1	Danio rerio	102-130
25576906-9	2015	The protective effect of progesterone was partially abolished by PGRMC1 inhibitor AG205 rather than classic PR antagonist RU486 in this study.	AG205	82-87	progesterone receptor membrane component 1	Rattus norvegicus	65-71
34585989-7	2021	Furthermore, treatment with AG205, a PGRMC1-specific inhibitor, or PGRMC1 knockout promoted H5N6 multiplication in vitro, while overexpression of PGRMC1 resulted in opposite effects.	AG205	28-33	progesterone receptor membrane component 1	Homo sapiens	37-43
34585989-8	2021	Furthermore, AG205 treatment or PGRMC1 knockout significantly inhibited the retinoic acid-inducible gene I (RIG-I)-mediated interferon beta (IFN-beta) signaling pathway and reduced the levels of several antiviral proteins (Mx1 and ISG15).	AG205	13-18	DExD/H-box helicase 58	Homo sapiens	108-113
34585989-8	2021	Furthermore, AG205 treatment or PGRMC1 knockout significantly inhibited the retinoic acid-inducible gene I (RIG-I)-mediated interferon beta (IFN-beta) signaling pathway and reduced the levels of several antiviral proteins (Mx1 and ISG15).	AG205	13-18	interferon beta 1	Homo sapiens	124-139
34585989-8	2021	Furthermore, AG205 treatment or PGRMC1 knockout significantly inhibited the retinoic acid-inducible gene I (RIG-I)-mediated interferon beta (IFN-beta) signaling pathway and reduced the levels of several antiviral proteins (Mx1 and ISG15).	AG205	13-18	IFN1@	Homo sapiens	141-149
34585989-8	2021	Furthermore, AG205 treatment or PGRMC1 knockout significantly inhibited the retinoic acid-inducible gene I (RIG-I)-mediated interferon beta (IFN-beta) signaling pathway and reduced the levels of several antiviral proteins (Mx1 and ISG15).	AG205	13-18	MX dynamin like GTPase 1	Homo sapiens	223-226
34585989-8	2021	Furthermore, AG205 treatment or PGRMC1 knockout significantly inhibited the retinoic acid-inducible gene I (RIG-I)-mediated interferon beta (IFN-beta) signaling pathway and reduced the levels of several antiviral proteins (Mx1 and ISG15).	AG205	13-18	ISG15 ubiquitin like modifier	Homo sapiens	231-236
34044033-10	2021	Progesterone decreased the expression of ACAT1, which could be blocked by progesterone receptor membrane component 1 (PGRMC1) inhibitor AG205.	AG205	136-141	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	41-46
34044033-10	2021	Progesterone decreased the expression of ACAT1, which could be blocked by progesterone receptor membrane component 1 (PGRMC1) inhibitor AG205.	AG205	136-141	progesterone receptor membrane component 1	Mus musculus	74-116
34044033-10	2021	Progesterone decreased the expression of ACAT1, which could be blocked by progesterone receptor membrane component 1 (PGRMC1) inhibitor AG205.	AG205	136-141	progesterone receptor membrane component 1	Mus musculus	118-124
26264726-8	2015	This enhancement can be blocked by the progesterone receptor membrane component 1 (PGRMC1) inhibitor AG205, or by the ADP scavenger apyrase and the cyclooxygenase inhibitor indomethacin.	AG205	101-106	progesterone receptor membrane component 1	Homo sapiens	83-89
25720537-6	2015	Co-treatment with the PGRMC1 inhibitor AG205 (20 muM) blocked the inhibitory effects of 100 nM estradiol-17beta and the GPER agonist, G-1, on spontaneous maturation of denuded zebrafish oocytes.	AG205	39-44	progesterone receptor membrane component 1	Danio rerio	22-28
25720537-6	2015	Co-treatment with the PGRMC1 inhibitor AG205 (20 muM) blocked the inhibitory effects of 100 nM estradiol-17beta and the GPER agonist, G-1, on spontaneous maturation of denuded zebrafish oocytes.	AG205	39-44	G protein-coupled estrogen receptor 1	Danio rerio	120-124