PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 10793295-10 2000 Hsp25 was slightly induced by hydrazine at later sampling times at concentrations, however, that affected other biochemical parameters. hydrazine 30-39 heat shock protein family B (small) member 1 Rattus norvegicus 0-5 11196866-1 2000 Depending on experimental conditions and the nature of the hydrazine, the reactions of ReCl3P3 [P = PPh(OEt)2] with RNHNH2 (R = H, CH3, tBu) afford the bis(dinitrogen) [Re(N2)2P4]+ (2+), dinitrogen ReClN2P4 (3), and methyldiazenido [ReCl(CH3N2)(CH3NHNH2)P3]+ (1+) derivatives. hydrazine 59-68 enolase 1 Homo sapiens 100-103 10230775-0 1999 Effect of hydrazine upon vitamin B12-dependent methionine synthase activity and the sulphur amino acid pathway in isolated rat hepatocytes. hydrazine 10-19 5-methyltetrahydrofolate-homocysteine methyltransferase Rattus norvegicus 25-66 10693974-10 1999 The enzymes catalase and superoxide dismutase and the antioxidant agent selenium showed some protection against hydrazine neurotoxicity, suggesting an involvement of the generation of reactive oxygen species in the pathogenesis of isoniazid neuropathy. hydrazine 112-121 catalase Mus musculus 12-20 10230775-1 1999 The effect of the industrial chemical, hydrazine (4-12 mM), on methionine synthase (EC 2.1.1.13) activity and levels of the sulphur amino acids homocysteine, cysteine, and taurine as well as GSH were investigated in vitro in isolated rat hepatocyte suspensions and monolayers in order to explain some of the adverse in vivo effects of hydrazine. hydrazine 39-48 5-methyltetrahydrofolate-homocysteine methyltransferase Rattus norvegicus 63-82 10230775-4 1999 Methionine synthase activity was reduced by hydrazine (8 and 12 mM) in suspensions (by 45 and 55%, after 3 hr) and monolayers (12 mM; 65-80% after 24 hr). hydrazine 44-53 5-methyltetrahydrofolate-homocysteine methyltransferase Rattus norvegicus 0-19 9632571-1 1998 Conjugate vaccines were prepared by binding hydrazine-treated lipopolysaccharide (DeALPS) from Vibrio cholerae O1, serotype Inaba, to cholera toxin (CT) variants CT-1 and CT-2. hydrazine 44-53 cardiotrophin 1 Homo sapiens 162-166 29711848-1 1999 Depending on the hydrazine reagent, Me3 Al reacts to afford novel aluminum-containing macrocyclic ring structures. hydrazine 17-26 malic enzyme 3 Homo sapiens 36-39 10192949-1 1999 The minimum energy paths for intramolecular proton transfer between the amino nitrogen and carbonyl oxygen atoms in gaseous protonated glycine were estimated at the Hartree-Fock (HF) and second-order Moller-Plesset Perturbation (MP2) levels of theory. hydrazine 72-86 tryptase pseudogene 1 Homo sapiens 229-232 21380894-3 1999 Protecting groups at amino nitrogen (typically carbamate such as Cbz or Boc) and the carboxyl group (typically ester) are usually present to make processing easier but must be readily and independently removable to permit extension in either the N-terminal or C-terminal directions (Fig. hydrazine 21-35 BOC cell adhesion associated, oncogene regulated Homo sapiens 72-75 9632571-1 1998 Conjugate vaccines were prepared by binding hydrazine-treated lipopolysaccharide (DeALPS) from Vibrio cholerae O1, serotype Inaba, to cholera toxin (CT) variants CT-1 and CT-2. hydrazine 44-53 cancer/testis antigen 2 Homo sapiens 171-175 9625846-4 1998 We examined the cytotoxicity of hydrazine sulfate in both human (LNCaP and PC-3) and animal (MAT-LyLu) prostate cancer cell lines. hydrazine 32-49 chromobox 8 Homo sapiens 75-79 9619734-1 1998 Human collagen type III was immobilized covalently via activated carbohydrate moieties onto hydrazine-treated microtiter plates which could be used to measure von Willebrand factor (vWF) collagen binding activity (vWF:CBA) in an ELISA. hydrazine 92-101 von Willebrand factor Homo sapiens 159-180 9619734-1 1998 Human collagen type III was immobilized covalently via activated carbohydrate moieties onto hydrazine-treated microtiter plates which could be used to measure von Willebrand factor (vWF) collagen binding activity (vWF:CBA) in an ELISA. hydrazine 92-101 von Willebrand factor Homo sapiens 182-185 9619734-1 1998 Human collagen type III was immobilized covalently via activated carbohydrate moieties onto hydrazine-treated microtiter plates which could be used to measure von Willebrand factor (vWF) collagen binding activity (vWF:CBA) in an ELISA. hydrazine 92-101 von Willebrand factor Homo sapiens 214-217 9389414-10 1997 The non-hydrazine SSAO inhibitor (E)-2-(4-fluorophenethyl)-3-fluoroallylamine hydrochloride (MDL-72974A) has been shown to reduce urinary excretion of lactate dehydrogenase (an indicator of nephropathy) in STZ-induced diabetic rats. hydrazine 8-17 amine oxidase, copper containing 3 Rattus norvegicus 18-22 23899329-4 1998 In addition to this, ATP and GSH levels and LDH leakage were measured over the following 8 h. The results show that increasing concentrations of hydrazine caused dose-dependent decreases in ATP and GSH levels over 8 h. There was no change in the levels of HSP25 or HSP72/3 over that period. hydrazine 145-154 lactate dehydrogenase B Rattus norvegicus 44-47 23899329-4 1998 In addition to this, ATP and GSH levels and LDH leakage were measured over the following 8 h. The results show that increasing concentrations of hydrazine caused dose-dependent decreases in ATP and GSH levels over 8 h. There was no change in the levels of HSP25 or HSP72/3 over that period. hydrazine 145-154 heat shock protein family B (small) member 1 Rattus norvegicus 256-261 23899329-4 1998 In addition to this, ATP and GSH levels and LDH leakage were measured over the following 8 h. The results show that increasing concentrations of hydrazine caused dose-dependent decreases in ATP and GSH levels over 8 h. There was no change in the levels of HSP25 or HSP72/3 over that period. hydrazine 145-154 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 265-270 9434138-5 1997 The level of cytochrome P-450 in freshly prepared hepatocytes from phenobarbital-treated rats was 2.5 times higher than that from the control rats, and remained about three times higher than the latter after 22 h of incubation with 2 mM hydrazine. hydrazine 237-246 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 13-29 9511458-6 1997 Substitution of chlorine at C-6 for an amine or thioether function was effected in the reactions with hydrazine, amines, and thiophenols. hydrazine 102-111 complement C6 Homo sapiens 28-31 9296352-1 1997 The purpose of this study was to determine the molecular basis in the dog for an unusual and absolute deficiency in the activity of cytosolic N-acetyltransferase (NAT), an enzyme important for the metabolism of arylamine and hydrazine compounds. hydrazine 225-234 bromodomain containing 2 Homo sapiens 163-166 8818569-10 1996 Northern blot analysis revealed that the observed increases in renal CYP2E1 protein levels after treatment with hydrazine or phenelzine were not accompanied by concomitant increases in CYP2E1 mRNA. hydrazine 112-121 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 69-75 9006110-6 1996 Alteration in DNA restriction by methyl-sensitive endonucleases was detected in four (DMT, c-Ha-ras, p53 and c-jun) of the seven genes examined and as early as 6 months in animals exposed to the highest concentration of hydrazine sulfate; alteration of recognition sites in c-Ha-ras was also detected in DNA from animals exposed for 21 months to the intermediate concentration of hydrazine sulfate. hydrazine 220-237 GTPase HRas Mesocricetus auratus 91-99 9006110-6 1996 Alteration in DNA restriction by methyl-sensitive endonucleases was detected in four (DMT, c-Ha-ras, p53 and c-jun) of the seven genes examined and as early as 6 months in animals exposed to the highest concentration of hydrazine sulfate; alteration of recognition sites in c-Ha-ras was also detected in DNA from animals exposed for 21 months to the intermediate concentration of hydrazine sulfate. hydrazine 220-237 cellular tumor antigen p53 Mesocricetus auratus 101-104 9006110-6 1996 Alteration in DNA restriction by methyl-sensitive endonucleases was detected in four (DMT, c-Ha-ras, p53 and c-jun) of the seven genes examined and as early as 6 months in animals exposed to the highest concentration of hydrazine sulfate; alteration of recognition sites in c-Ha-ras was also detected in DNA from animals exposed for 21 months to the intermediate concentration of hydrazine sulfate. hydrazine 220-237 GTPase HRas Mesocricetus auratus 274-282 11666671-3 1996 The solid state structure of [Cu(CDhm)(L-TrpO)](+) shows that the aromatic side chain of TrpO(-) is outside the cavity and that the two amino nitrogen atoms, one from the histamine molecule and one from the amino acidate, are in a cis disposition. hydrazine 136-150 tryptophan 2,3-dioxygenase Homo sapiens 41-45 8818569-1 1996 The hepatic and renal toxicity associated with hydrazine treatment has been linked to free radical damage resulting from oxidative metabolism by cytochrome P4502E1 (CYP2E1). hydrazine 47-56 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 165-171 8818569-2 1996 Despite this association, there has been little characterization of the effects of hydrazine treatment on the expression of hepatic and renal CYP2E1 or glutathione-S-transferase-alpha (GST-alpha), an enzyme responsible for catalyzing the conjugation of free radicals with reduced glutathione. hydrazine 83-92 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 142-148 8818569-3 1996 Therefore, the effects of treatment with hydrazine or one of the therapeutic hydrazines phenelzine and hydralazine on rat hepatic and renal CYP2E1 and GST-alpha expression were investigated. hydrazine 41-50 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 140-146 8818569-7 1996 In addition, hydrazine and phenelzine treatment produced substantial elevations (approximately 464% and 566%, respectively) in renal CYP2E1 protein, whereas hydralazine administration did not alter renal CYP2E1 expression. hydrazine 13-22 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 133-139 8818569-11 1996 These results suggest that treatment with hydrazine or the therapeutic hydrazine phenelzine significantly increases the expression of rat renal CYP2E1 protein, and that the molecular mechanism responsible for these effects are posttranscriptional in nature. hydrazine 42-51 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 144-150 9156695-1 1996 The hepatic N-acetyltransferase enzyme encoded by the NAT2* gene locus is responsible for the human polymorphic acetylation of numerous arylamine or hydrazine-containing drugs and xenobiotics including AIDS-related therapeutic agents such as isoniazid and sulphonamides. hydrazine 149-158 N-acetyltransferase 2 Homo sapiens 54-58 8576911-0 1996 Slow-binding inhibition of gamma-aminobutyric acid aminotransferase by hydrazine analogues. hydrazine 71-80 4-aminobutyrate aminotransferase Homo sapiens 27-67 8915350-4 1996 Hepatotoxic compounds such as CCl4, galactosamine and thioacetamide that cause hepatic necrosis and compounds such as hydrazine and ethionine that cause fatty liver all result in elevated urinary taurine levels in rats. hydrazine 118-127 C-C motif chemokine ligand 4 Rattus norvegicus 30-34 8845861-12 1996 NAT2 16A exhibited 500-to 1000-fold lower maximum velocities compared to NAT2 15 for N-acetylation of all arylamine and hydrazine substrates tested. hydrazine 120-129 arylamine N-acetyltransferase 2 Mesocricetus auratus 0-4 8845861-12 1996 NAT2 16A exhibited 500-to 1000-fold lower maximum velocities compared to NAT2 15 for N-acetylation of all arylamine and hydrazine substrates tested. hydrazine 120-129 arylamine N-acetyltransferase 2 Mesocricetus auratus 73-80 18472809-1 1996 Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase. hydrazine 40-49 tankyrase 2 Homo sapiens 0-6 8639971-1 1996 Aminoguanidine, nucleophilic hydrazine derivative, has been shown to inhibit diamine oxidase, the formation of advanced glycation endproducts, nitric oxide synthase, and catalase. hydrazine 29-38 amine oxidase, copper containing 1 Rattus norvegicus 77-92 8639971-1 1996 Aminoguanidine, nucleophilic hydrazine derivative, has been shown to inhibit diamine oxidase, the formation of advanced glycation endproducts, nitric oxide synthase, and catalase. hydrazine 29-38 catalase Rattus norvegicus 170-178 8634828-1 1995 The purpose of this research is to study the relationship between chemical structure and inhibitory activity of some hydrazine-thiazole derivatives on rat liver mitochondria monoamine oxidase (MAO). hydrazine 117-126 monoamine oxidase A Rattus norvegicus 174-191 8634828-1 1995 The purpose of this research is to study the relationship between chemical structure and inhibitory activity of some hydrazine-thiazole derivatives on rat liver mitochondria monoamine oxidase (MAO). hydrazine 117-126 monoamine oxidase A Rattus norvegicus 193-196 7817767-1 1994 The Friedel-Crafts reaction of benzene with cis-4-cyclohexene-1,2-dicarboxylic anhydride (1) yields trans-5-phenyl-cis-2-benzoylcyclohexanecarboxylic acid (2), which gave cyclohexane-condensed pyridazinone (3) with hydrazine, and cis-4,5-tetramethylene-1,2-oxazin-8-one (4) with hydroxylamine. hydrazine 215-224 suppressor of cytokine signaling 6 Homo sapiens 44-49 8576911-21 1996 Implications for the design of hydrazine inhibitors of GABA-AT are discussed. hydrazine 31-40 4-aminobutyrate aminotransferase Homo sapiens 55-62 7669073-1 1995 Arylamine N-acetyltransferase (NAT2) catalyses the N-acetylation of primary arylamine and hydrazine drugs and chemicals. hydrazine 90-99 N-acetyltransferase 2 Homo sapiens 31-35 7619827-1 1995 In the presence of a suitable electron acceptor such as mammalian cytochrome c, hydroxylamine oxidoreductase (HAO) from the chemolithotrophic bacterium Nitrosomonas europaea catalyzes the oxidation of hydroxylamine or hydrazine to nitrite or dinitrogen, respectively. hydrazine 218-227 cytochrome c, somatic Homo sapiens 66-78 7648206-2 1995 Hydrazine analogues have long been known to act as inactivators of PLP-dependent enzymes, including GABA aminotransferase, however, no studies of the molecular mechanism of inactivation of PLP-dependent enzymes by hydrazines have been reported. hydrazine 0-9 4-aminobutyrate aminotransferase Sus scrofa 100-121 7929420-2 1994 The human arylamine N-acetyltransferases NAT1 and NAT2 catalyze the biotransformation of primary aromatic amine or hydrazine drugs and xenobiotics. hydrazine 115-124 N-acetyltransferase 1 Homo sapiens 41-45 7929420-2 1994 The human arylamine N-acetyltransferases NAT1 and NAT2 catalyze the biotransformation of primary aromatic amine or hydrazine drugs and xenobiotics. hydrazine 115-124 N-acetyltransferase 2 Homo sapiens 50-54 7817767-1 1994 The Friedel-Crafts reaction of benzene with cis-4-cyclohexene-1,2-dicarboxylic anhydride (1) yields trans-5-phenyl-cis-2-benzoylcyclohexanecarboxylic acid (2), which gave cyclohexane-condensed pyridazinone (3) with hydrazine, and cis-4,5-tetramethylene-1,2-oxazin-8-one (4) with hydroxylamine. hydrazine 215-224 suppressor of cytokine signaling 2 Homo sapiens 115-120 7817767-1 1994 The Friedel-Crafts reaction of benzene with cis-4-cyclohexene-1,2-dicarboxylic anhydride (1) yields trans-5-phenyl-cis-2-benzoylcyclohexanecarboxylic acid (2), which gave cyclohexane-condensed pyridazinone (3) with hydrazine, and cis-4,5-tetramethylene-1,2-oxazin-8-one (4) with hydroxylamine. hydrazine 215-224 suppressor of cytokine signaling 6 Homo sapiens 230-235 7982269-0 1994 Contribution of tumor necrosis factor-alpha and glucocorticoid in hydrazine sulfate-mediated protection against endotoxin lethality. hydrazine 66-83 tumor necrosis factor Mus musculus 16-43 8209382-6 1994 The results indicated that one or more MspI restriction sites (5"-C decreases CGG-3") were lost or blocked in liver DNA from hydrazine-treated animals and that these sites were located at or near the genes for gamma-glutamyl transpeptidase and cytochrome P450 IIB1. hydrazine 125-134 gamma-glutamyltransferase 1 Rattus norvegicus 210-239 20692930-9 1994 The results of this study indicate the following: (a) the sensitivity of cultured hepatocytes to hydrazine is no greater than that of hepatocytes in suspension; (b) the duration of exposure to hydrazine is important but the effect depends on the parameter measured; (c) hydrazine causes a dose-dependent inhibition of protein synthesis at much lower concentrations than those causing LDH leakage; (d) maintenance of cytochrome P-450 in cultured hepatocytes by exposure to metyrapone did not alter the cytotoxicity of hydrazine. hydrazine 193-202 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 416-432 20692930-9 1994 The results of this study indicate the following: (a) the sensitivity of cultured hepatocytes to hydrazine is no greater than that of hepatocytes in suspension; (b) the duration of exposure to hydrazine is important but the effect depends on the parameter measured; (c) hydrazine causes a dose-dependent inhibition of protein synthesis at much lower concentrations than those causing LDH leakage; (d) maintenance of cytochrome P-450 in cultured hepatocytes by exposure to metyrapone did not alter the cytotoxicity of hydrazine. hydrazine 193-202 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 416-432 20692930-9 1994 The results of this study indicate the following: (a) the sensitivity of cultured hepatocytes to hydrazine is no greater than that of hepatocytes in suspension; (b) the duration of exposure to hydrazine is important but the effect depends on the parameter measured; (c) hydrazine causes a dose-dependent inhibition of protein synthesis at much lower concentrations than those causing LDH leakage; (d) maintenance of cytochrome P-450 in cultured hepatocytes by exposure to metyrapone did not alter the cytotoxicity of hydrazine. hydrazine 193-202 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 416-432 7982269-5 1994 The results presented here establish that hydrazine sulfate pretreatment selectively attenuates circulating TNF levels following LPS challenge. hydrazine 42-59 tumor necrosis factor Mus musculus 108-111 7982269-8 1994 Thus, the mechanism by which hydrazine sulfate protects against LPS lethality in adrenalectomized mice includes TNF modulation in response to endotoxin, as well as a pivotal requirement for glucocorticoid. hydrazine 29-46 tumor necrosis factor Mus musculus 112-115 7982269-1 1994 Hydrazine sulfate pretreatment has previously been shown in our laboratory to protect normal mice against endotoxin and D-galactosamine-sensitized mice against both exogenous tumor necrosis factor (TNF) and endotoxin. hydrazine 0-17 tumor necrosis factor Mus musculus 175-196 7982269-1 1994 Hydrazine sulfate pretreatment has previously been shown in our laboratory to protect normal mice against endotoxin and D-galactosamine-sensitized mice against both exogenous tumor necrosis factor (TNF) and endotoxin. hydrazine 0-17 tumor necrosis factor Mus musculus 198-201 7982269-3 1994 Further, we have demonstrated that hydrazine sulfate pretreatment specifically modulates the TNF response to lipopolysaccharide (LPS) in mouse macrophages in vitro. hydrazine 35-52 tumor necrosis factor Mus musculus 93-96 8182542-4 1994 Arylamine N-acetyltransferase (NAT) catalyzes the acetyl CoA-dependent N-acetylation of primary arylamine and hydrazine substrates such as sulfamethazine, isoniazid, p-aminobenzoic acid as well as arylamine carcinogens such as 2-aminofluorene and benzidine. hydrazine 110-119 bromodomain containing 2 Homo sapiens 31-34 8155661-4 1994 The adduct with the unsubstituted hydrazine was instead assigned an o-quinone hydrazone form, stabilized by an internal hydrogen bond between the amino group and the ortho carbonyl oxygen, a larger electron delocalization, and formation of a hydrogen bond at the C-6 ionized hydroxyl. hydrazine 34-43 complement C6 Homo sapiens 263-266 8013062-0 1994 Hydrazine sulfate selectively modulates the TNF response to endotoxin in mouse macrophages. hydrazine 0-17 tumor necrosis factor Mus musculus 44-47 7931216-6 1994 The results of these investigations suggest that the free hydrazine moiety in PLZ is crucial to producing the elevated levels of GABA, probably through inhibition of GABA-T. hydrazine 58-67 4-aminobutyrate aminotransferase Rattus norvegicus 166-172 8396914-1 1993 Many arylamine and hydrazine drugs and xenobiotics are acetylated by liver N-acetyltransferase (NAT; EC 2.3.1.5). hydrazine 19-28 bromodomain containing 2 Homo sapiens 75-94 8396914-1 1993 Many arylamine and hydrazine drugs and xenobiotics are acetylated by liver N-acetyltransferase (NAT; EC 2.3.1.5). hydrazine 19-28 bromodomain containing 2 Homo sapiens 96-99 1872889-4 1991 The second locus encodes an NAT which is termed polymorphic NAT (pNAT), has a distinct tissue distribution and is responsible for the difference in ability between individuals in acetylating certain arylamine (e.g. sulphamethazine) and hydrazine (e.g. isoniazid) drugs which are polymorphic substrates. hydrazine 236-245 bromodomain containing 2 Homo sapiens 28-31 8096696-2 1993 This study was done to determine if the concentration of the hydrazine derivative 3-hydroxybenzylhydrazine (NSD-1015), a drug frequently used in vitro to inhibit AAAD, could be adjusted such that it would inhibit that enzyme, but would not simultaneously inhibit a second, potentially important enzyme, monoamine oxidase (MAO; EC 1.4.3.4). hydrazine 61-70 dopa decarboxylase Canis lupus familiaris 162-166 1321617-3 1992 In addition, hydrazine-trapping experiments indicate that C-4" hydroxylated abasic sites are formed concomitant with DNA degradation by Fe(II)-elsamicin A. hydrazine 13-22 complement C4A (Rodgers blood group) Homo sapiens 58-61 7901387-3 1993 These experiments suggest that a free hydrazine group is necessary for MAO inhibitors to also have marked effects on GABA and ALA. hydrazine 38-47 monoamine oxidase A Rattus norvegicus 71-74 8419650-7 1993 Fragmentation of the gp120-derived 35SO4-labeled glycopeptides by treatment with hydrazine and nitrous acid and subsequent reduction generated galactosyl-anhydromannitol-6-35SO4, which is the expected reaction product from GlcNAc-6-sulfate within a sulfated lactosamine moiety. hydrazine 81-90 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 21-26 7908197-2 1993 In this study, hydrazine sulfate, an inhibitor of low Km ALDH and gluconeogenetic enzymes, was fed with ethanol to rats, and produced more serious pathological changes compared with those found in Lieber"s model. hydrazine 15-32 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 57-61 1872889-4 1991 The second locus encodes an NAT which is termed polymorphic NAT (pNAT), has a distinct tissue distribution and is responsible for the difference in ability between individuals in acetylating certain arylamine (e.g. sulphamethazine) and hydrazine (e.g. isoniazid) drugs which are polymorphic substrates. hydrazine 236-245 N-acetyltransferase 2 Homo sapiens 48-63 1872889-4 1991 The second locus encodes an NAT which is termed polymorphic NAT (pNAT), has a distinct tissue distribution and is responsible for the difference in ability between individuals in acetylating certain arylamine (e.g. sulphamethazine) and hydrazine (e.g. isoniazid) drugs which are polymorphic substrates. hydrazine 236-245 N-acetyltransferase 2 Homo sapiens 65-69 1885704-2 1991 It was first converted into the pyruvate hydrazone in the presence of D-lactate dehydrogenase, an NADH-reoxidation system using diaphorase, D,L-6,8-thioctamide and hydrazine. hydrazine 164-173 lactate dehydrogenase D Homo sapiens 70-93 1649016-4 1991 Hydrazine was also oxidized by catalase but only hydroxyl radicals were detected. hydrazine 0-9 catalase Homo sapiens 31-39 1846358-3 1991 Hydrazine caused DNA damage in the presence of Mn(III), Mn(II), Cu(II), Co(II), and Fe(III). hydrazine 0-9 mitochondrially encoded cytochrome c oxidase II Homo sapiens 72-77 2015283-1 1991 Many arylamine and hydrazine drugs and xenobiotics are acetylated by N-acetyltransferase (NAT), a cytosolic enzymic activity which has a wide tissue distribution. hydrazine 19-28 bromodomain containing 2 Homo sapiens 69-88 2015283-1 1991 Many arylamine and hydrazine drugs and xenobiotics are acetylated by N-acetyltransferase (NAT), a cytosolic enzymic activity which has a wide tissue distribution. hydrazine 19-28 bromodomain containing 2 Homo sapiens 90-93 1988538-0 1991 Hydrazine sulfate protects D-galactosamine-sensitized mice against endotoxin and tumor necrosis factor/cachectin lethality: evidence of a role for the pituitary. hydrazine 0-17 tumor necrosis factor Mus musculus 103-112 1988538-16 1991 Hydrazine sulfate pretreatment also protects D-galactosamine-sensitized mice against the lethal effects of injected tumor necrosis factor/cachectin. hydrazine 0-17 tumor necrosis factor Mus musculus 138-147 1846358-4 1991 The order of inducing effect on hydrazine-dependent DNA damage (Mn(III) greater than Mn(II) approximately Cu(II) much greater than Co(II) approximately Fe(III)) was related to that of the accelerating effect on the O2 consumption rate of hydrazine autoxidation. hydrazine 238-247 mitochondrially encoded cytochrome c oxidase II Homo sapiens 131-136 1673622-2 1991 N-acetyl transferase (NAT) catalyses the acetylation of arylamine and hydrazine drugs and other xenobiotics. hydrazine 70-79 bromodomain containing 2 Homo sapiens 0-20 1673622-2 1991 N-acetyl transferase (NAT) catalyses the acetylation of arylamine and hydrazine drugs and other xenobiotics. hydrazine 70-79 bromodomain containing 2 Homo sapiens 22-25 1846358-4 1991 The order of inducing effect on hydrazine-dependent DNA damage (Mn(III) greater than Mn(II) approximately Cu(II) much greater than Co(II) approximately Fe(III)) was related to that of the accelerating effect on the O2 consumption rate of hydrazine autoxidation. hydrazine 32-41 mitochondrially encoded cytochrome c oxidase II Homo sapiens 131-136 34846842-4 2021 The labeled O-GlcNAc glycopeptides could be efficiently enriched based on the equilibrium between the hydrazine and oxime bonds. hydrazine 102-111 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 12-20 1970632-7 1990 Tertiary butyl substitution on the amino nitrogen gave the highest beta 2-adrenoceptor selectivity in both the catechol and resorcinol series. hydrazine 35-49 beta-2 adrenergic receptor Cavia porcellus 67-86 34075758-3 2021 The hydrazine group of PHN acts as the specific reaction group with FA based on the condensation reaction. hydrazine 4-13 carbamoyl-phosphate synthase 1 Homo sapiens 23-26 34105531-1 2021 By utilizing hydrazine (N2H4) as the nitrogen source in the presence of a hydroxyapatite-supported Pd nanoparticle catalyst (Pd/HAP), various primary anilines can be selectively synthesized from cyclohexanones via acceptorless dehydrogenative aromatization. hydrazine 13-22 BAG cochaperone 1 Homo sapiens 128-131 34105531-1 2021 By utilizing hydrazine (N2H4) as the nitrogen source in the presence of a hydroxyapatite-supported Pd nanoparticle catalyst (Pd/HAP), various primary anilines can be selectively synthesized from cyclohexanones via acceptorless dehydrogenative aromatization. hydrazine 24-28 BAG cochaperone 1 Homo sapiens 128-131 34168185-8 2021 Therefore, the main behaviors of the N2H4 + OH reaction have been explored according to the influences of temperature and pressure on the computed rate coefficients within the well-behaved theoretical frameworks of the TST, VTST, and RRKM theories. hydrazine 37-41 thiosulfate sulfurtransferase Homo sapiens 219-222 34214766-7 2021 It was reported that metabolites of INH, such as acetylhydrazine and hydrazine, were bioactivated by CYP2E1, highlighting that perhaps the drug metabolites were responsible for the mechanism based inhibition (MBI) of the enzyme. hydrazine 69-78 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 101-107 34214766-8 2021 Therefore, the purpose of this investigation was to explore CYP2E1 enzyme inhibition potential of INH and its four major metabolites, viz., acetylisoniazid, isonicotinic acid, acetylhydrazine and hydrazine, using human liver microsomes (HLM). hydrazine 196-205 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 60-66 2708033-4 1989 Upon subsequent treatment with hydrazine sulfate, glucokinase activity further decreased, and liver cytosolic phosphoenolpyruvate carboxykinase activity increased. hydrazine 31-48 glucokinase Rattus norvegicus 50-61 35635370-7 2022 The ester group of the probe reacts with hydrazine to generate Cy-H, causing a change in fluorescence. hydrazine 41-50 chymase 1 Homo sapiens 63-67 2587673-1 1989 The rat studies presented in this manuscript show that the new non-hydrazine compounds moclobemide, brofaromine and toloxatone have a profile typical of monoamine oxidase-A (MAO-A) inhibitors. hydrazine 67-76 monoamine oxidase A Rattus norvegicus 174-179 35235319-2 2022 More recently, reverse-polarity (RP)-ABPP using hydrazine probes identified an electrophilic N-terminal glyoxylyl (Glox) group for the first time in secernin-3 (SCRN3). hydrazine 48-57 amyloid beta precursor protein Homo sapiens 37-41 35235319-2 2022 More recently, reverse-polarity (RP)-ABPP using hydrazine probes identified an electrophilic N-terminal glyoxylyl (Glox) group for the first time in secernin-3 (SCRN3). hydrazine 48-57 secernin 3 Homo sapiens 149-159 35235319-2 2022 More recently, reverse-polarity (RP)-ABPP using hydrazine probes identified an electrophilic N-terminal glyoxylyl (Glox) group for the first time in secernin-3 (SCRN3). hydrazine 48-57 secernin 3 Homo sapiens 161-166 2546565-2 1989 Oxidation of isoniazid or hydrazine sulphate at pH values of 6.5 or 7.8 in a myeloperoxidase-H2O2 system caused considerable haem loss, which was associated with compound III formation. hydrazine 26-44 myeloperoxidase Homo sapiens 77-92 2807626-1 1989 Experiments were performed to determine the effects of hydrazine sulfate (HS), a potential anti-cachexia agent, on tumor necrosis factor activities (cachectin/TNF) in vitro. hydrazine 55-72 tumor necrosis factor Mus musculus 149-158 2807626-1 1989 Experiments were performed to determine the effects of hydrazine sulfate (HS), a potential anti-cachexia agent, on tumor necrosis factor activities (cachectin/TNF) in vitro. hydrazine 74-76 tumor necrosis factor Mus musculus 149-158 2807626-2 1989 We present evidence that HS significantly inhibits the lytic activity of TNF on L-929 cells, that HS has no direct effect on TNF itself, and that the minimum amount of time for maximum inhibition of TNF activity to occur after HS treatment is between 1 and 4 h. In addition to HS"s effect on the cytolytic activity, we also determined its effect on the antiviral activity of TNF. hydrazine 25-27 tumor necrosis factor Mus musculus 73-76 2807626-3 1989 We found that HS greatly potentiates TNF antiviral activity, while having no significant antiviral activity itself over a range of concentrations, that the potentiation was likely between HS and TNF-induced interferon-B1, and was maximal following 4 and 8 h of treatment with HS. hydrazine 14-16 tumor necrosis factor Mus musculus 37-40 2807626-3 1989 We found that HS greatly potentiates TNF antiviral activity, while having no significant antiviral activity itself over a range of concentrations, that the potentiation was likely between HS and TNF-induced interferon-B1, and was maximal following 4 and 8 h of treatment with HS. hydrazine 14-16 tumor necrosis factor Mus musculus 195-198 2837203-0 1988 Hydrazine radical formation catalyzed by rat microsomal NADPH-cytochrome P-450 reductase. hydrazine 0-9 cytochrome p450 oxidoreductase Rattus norvegicus 56-88 2481842-3 1989 Upon heating with neutral hydrazine (90 degrees C, 5 min) C-4"-hydroxylated abasic site formed by photo-excited Co(III)bleomycin was converted to the fragments having 3"-phosphoro-3""-pyridazinylmethylate as illustrated on Scheme 1. hydrazine 26-35 complement C4 Bos taurus 58-61 3209851-1 1988 The human polymorphism in the hepatic enzyme N-acetyltransferase (NAT) affects the rate at which individuals acetylate, and in many cases detoxify, aromatic amine and hydrazine drugs and xenobiotics. hydrazine 167-176 solute carrier family 38, member 3 Mus musculus 45-64 3209851-1 1988 The human polymorphism in the hepatic enzyme N-acetyltransferase (NAT) affects the rate at which individuals acetylate, and in many cases detoxify, aromatic amine and hydrazine drugs and xenobiotics. hydrazine 167-176 bromodomain containing 2 Homo sapiens 66-69 3243781-1 1988 D-Lactate in biological samples was converted into the hydrazone of pyruvate in the presence of D-lactate dehydrogenase, an NADH-reoxidation system using diaphorase, DL-6,8-thioctamide and hydrazine. hydrazine 189-198 lactate dehydrogenase D Homo sapiens 96-119 3219230-0 1988 Hydrazine stress in the diabetic: ornithine decarboxylase activity. hydrazine 0-9 ornithine decarboxylase 1 Rattus norvegicus 34-57 3219230-2 1988 Hydrazine treatment of 4 hr duration stimulated equally kidney ornithine decarboxylase activities of nondiabetic and diabetic rats. hydrazine 0-9 ornithine decarboxylase 1 Rattus norvegicus 63-86 3219230-3 1988 Hydrazine treatment increased liver ornithine decarboxylase activity in the nondiabetic rat but did not increase it in the diabetic rat. hydrazine 0-9 ornithine decarboxylase 1 Rattus norvegicus 36-59 3219230-4 1988 Since hydrazine stimulates ornithine decarboxylase activity prior to polyamine and protein syntheses, we speculate that the lack of hydrazine stimulation of ornithine decarboxylase in the diabetic liver may be related in part to the unrestrained gluconeogenesis and depressed Kreb"s cycle activity: the latter being required for protein synthesis. hydrazine 6-15 ornithine decarboxylase 1 Rattus norvegicus 27-50 2837203-1 1988 Using NADPH-cytochrome P-450 reductase purified from rat liver microsomes, the oxidation of hydrazine to its radical was proved to proceed smoothly. hydrazine 92-101 cytochrome p450 oxidoreductase Rattus norvegicus 6-38 2837203-4 1988 The present study provides the first evidence for the NADPH-cytochrome P-450 reductase catalyzed oxidation of hydrazine to its radical in the presence of O2 and NADPH. hydrazine 110-119 cytochrome p450 oxidoreductase Rattus norvegicus 54-86 3427016-2 1987 The most significant effects of binding were large downfield shifts in the amino nitrogen resonance of Phe-3 of vasopressin and in its associated proton, providing evidence that the peptide bond between residues 2 and 3 of the hormones is hydrogen-bonded to the protein within hormone-neurophysin complexes. hydrazine 75-89 dihydrolipoamide dehydrogenase Homo sapiens 103-108 3394950-5 1988 They were converted to hydrazine derivatives and covalently attached to cell surface oligosaccharides, which had been treated with periodate or neuraminidase and galactose oxidase. hydrazine 23-32 neuraminidase 1 Homo sapiens 144-157 3335049-0 1988 Role of formaldehyde hydrazone and catalase in hydrazine-induced methylation of DNA guanine. hydrazine 47-56 catalase Rattus norvegicus 35-43 3335049-8 1988 Bovine liver catalase, a heme-containing cytochrome, readily transformed hydrazine/formaldehyde to a methylating agent. hydrazine 73-82 catalase Bos taurus 13-21 3335049-9 1988 The data support formation of formaldehyde hydrazone as the condensation product of hydrazine and formaldehyde which is rapidly transformed in various liver cell fractions, perhaps by catalase and/or catalase-like enzymes, to a methylating agent. hydrazine 84-93 catalase Bos taurus 184-192 3335049-9 1988 The data support formation of formaldehyde hydrazone as the condensation product of hydrazine and formaldehyde which is rapidly transformed in various liver cell fractions, perhaps by catalase and/or catalase-like enzymes, to a methylating agent. hydrazine 84-93 catalase Bos taurus 200-208 3126736-4 1988 Other pyrazoline derivatives such as BW 755C, but also, in a more general manner, different compounds containing phenol, aniline, hydrazine, hydroxylamine or hydrazide functions act as reducing substrates for decomposition of 13-HPOD by L1. hydrazine 130-139 seed linoleate 13S-lipoxygenase-1 Glycine max 237-239 3427016-2 1987 The most significant effects of binding were large downfield shifts in the amino nitrogen resonance of Phe-3 of vasopressin and in its associated proton, providing evidence that the peptide bond between residues 2 and 3 of the hormones is hydrogen-bonded to the protein within hormone-neurophysin complexes. hydrazine 75-89 arginine vasopressin Homo sapiens 112-123 2955429-5 1987 Introduction of amino acids between the arylsulfonyl blocking group and amino nitrogen influence particularly the antithrombin activity. hydrazine 72-86 serpin family C member 1 Homo sapiens 114-126 3549860-6 1987 Plasma IGF-2 activity was correlated positively with plasma glucose, fructose and alpha-amino nitrogen levels and inversely related to the plasma insulin concentration in utero. hydrazine 88-102 insulin-like growth factor II Ovis aries 7-12 16665163-11 1986 The labeling kinetics of the amino nitrogen groups of glutamine and glutamate are consistent with the operation of the glutamine synthetase-glutamate synthase cycle in both cell lines. hydrazine 29-43 glutamine synthetase Solanum lycopersicum 119-139 2881653-1 1987 The biological activity of recombinant-DNA-derived chicken growth hormone (rcGH) has been examined in young broiler cockerels, by determining its effects on plasma concentrations of glucose, free fatty acids and alpha-amino nitrogen. hydrazine 218-232 growth hormone Gallus gallus 59-73 2432677-6 1986 Similar results were obtained with the alpha 2M inhibitor, hydrazine. hydrazine 59-68 alpha-2-macroglobulin Homo sapiens 39-47 3745178-7 1986 The effects of the nucleophiles hydroxylamine, hydrazine, and ethylenediamine on Km and Vmax for lipoprotein lipase catalyzed hydrolysis of p-nitrophenyl laurate are consistent with trapping of a lauryl-lipoprotein lipase intermediate. hydrazine 47-56 lipoprotein lipase Bos taurus 97-115 3745178-7 1986 The effects of the nucleophiles hydroxylamine, hydrazine, and ethylenediamine on Km and Vmax for lipoprotein lipase catalyzed hydrolysis of p-nitrophenyl laurate are consistent with trapping of a lauryl-lipoprotein lipase intermediate. hydrazine 47-56 lipoprotein lipase Bos taurus 203-221 3007460-1 1986 Dopamine beta-hydroxylase is inactivated by phenyl-, phenethyl-, benzyl-, and methylhydrazine, but not by hydrazine itself. hydrazine 84-93 dopamine beta-hydroxylase Homo sapiens 0-25 3271870-2 1986 Cytochrome P-450 preferentially oxidized the nitrogen to nitrogen bond of 1,2-disubstituted hydrazines and hydrazides, while monoamine oxidase oxidized the nitrogen to nitrogen bond of all the classes of hydrazine derivatives that were tested. hydrazine 92-101 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 3937332-3 1985 Significant differences in BSA and OVA digestion by the gastric juice--FGS system were detected both with respect to amino nitrogen content and to the degree of their antigenic structure decomposition, whereas no such differences were observed when the four-enzymic system was used. hydrazine 117-131 ovalbumin (SERPINB14) Gallus gallus 35-38 3002363-0 1985 Spin trapping of a free radical intermediate formed during microsomal metabolism of hydrazine. hydrazine 84-93 spindlin 1 Rattus norvegicus 0-4 3002363-1 1985 A radical formed during oxidative metabolism of hydrazine in rat liver microsomes was spin-trapped with alpha-phenyl-t-butylnitrone. hydrazine 48-57 spindlin 1 Rattus norvegicus 86-90 6506753-0 1984 The interactions of hydrazine derivatives with rat-hepatic cytochrome P-450. hydrazine 20-29 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 59-75 4018566-0 1985 Effect of mammalian growth hormone on amino nitrogen mobilization in the eel. hydrazine 38-52 growth hormone 1 Homo sapiens 20-34 3157886-2 1985 The brain contained hydrazine, a terminal metabolite of INH, which inhibits gamma-aminobutyric acid (GABA) aminotransferase. hydrazine 20-29 4-aminobutyrate aminotransferase Homo sapiens 76-123 3271870-1 1986 The enzyme systems in rat liver and lung responsible for the oxidative metabolism of hydrazine derivatives were studied to determine whether these enzymes, cytochrome P-450 and monoamine oxidase, were responsible for metabolically activating hydrazines to carcinogenic/toxic metabolites. hydrazine 85-94 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 156-172 6506753-1 1984 The ability of different classes of hydrazine derivatives to modify cytochrome P-450 function during turnover as judged by loss of absorbance at 416 nm, loss of CO-reactive cytochrome P-450, or destruction of haem has been studied. hydrazine 36-45 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 68-84 6883596-0 1983 Evidence for involvement of liver aldehyde oxidase in reduction of nitrosamines to the corresponding hydrazine. hydrazine 101-110 aldehyde oxidase 1 Homo sapiens 34-50 6413506-6 1983 Pronase-released glycopeptides and hydrazine-released oligosaccharides of isolated fibronectin from the culture media were analyzed using endo-beta-N-acetylglucosaminidase H and specific exoglycosidase digestions in conjunction with calibrated gel filtration chromatography. hydrazine 35-44 fibronectin 1 Homo sapiens 83-94 6202192-1 1983 The inactivation of alpha 2M by the nucleophiles, NH4+, hydrazine, and methylamine, follows pseudo-first-order (second order, overall) rates. hydrazine 56-65 alpha-2-macroglobulin Homo sapiens 20-28 6873627-0 1983 In vitro screening of the effect of hydrazine derivatives on hepatic aryl hydrocarbon hydroxylase activity. hydrazine 36-45 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 69-97 6873627-2 1983 The effect of hydrazine derivatives on the in vitro hepatic microsomal aryl hydrocarbon hydroxylase activity was examined using Sprague-Dawley male rats. hydrazine 14-23 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 71-99 6873627-4 1983 All hydrazine derivatives examined have some degree of inhibition on hepatic aryl hydrocarbon hydroxylase activity. hydrazine 4-13 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 77-105 7225016-3 1981 In contrast to the general feeling that hydrazine degrades in the presence of atmospheric oxygen, studies show hydrazine is relatively stable in both air (t1/2 approximately 6 h) and oxygenated aqueous solutions (t1/2 approximately 5 d). hydrazine 111-120 interleukin 1 receptor like 1 Homo sapiens 155-177 6807052-6 1982 At III was easily dissociated from the thickened TBM after the incubation in warm (37 degrees C) 0.01 M phosphate buffered saline of various pH (pH 4.0, pH 7.2 or pH 10.0) and cold (4 degrees C) or warm (37 degrees C) 0.75 M hydrazine solutions of the same pH, while alpha 1AT was not dissociated from the atrophic nephrons after the incubation in all solutions. hydrazine 225-234 serpin family C member 1 Homo sapiens 0-6 7252511-2 1981 In contrast, hydrazine (5 micrometers) caused a 50% inhibition of GABA-T without inhibiting glutamic acid decarboxylase (GAD). hydrazine 13-22 4-aminobutyrate aminotransferase Rattus norvegicus 66-72 7252511-4 1981 Both hydrazine doses caused significant elevations of whole brain GABA content and reductions of GABA-T activity, but did not affect GAD activity. hydrazine 5-14 4-aminobutyrate aminotransferase Rattus norvegicus 97-103 7252511-7 1981 Inhibition of GABA-T activity and the other biochemical alterations observed in patients given high doses of INH probably result from hydrazine formed in the metabolic degradation of INH. hydrazine 134-143 4-aminobutyrate aminotransferase Homo sapiens 14-20 6809759-3 1982 In this study, we report the characterization of the endoglycosidase H-resistant oligosaccharides which were released from beta-glucuronidase with anhydrous hydrazine. hydrazine 157-166 glucuronidase beta Homo sapiens 123-141 6976993-3 1982 We report here that C4 treated with N2H4 or KSCN or frozen-thawed, unlike native C4, forms a complex with C4-binding protein (C4-bp) and is cleaved by C3b/C4b inactivator (I). hydrazine 36-40 complement component 4 binding protein alpha Homo sapiens 106-124 6976993-3 1982 We report here that C4 treated with N2H4 or KSCN or frozen-thawed, unlike native C4, forms a complex with C4-binding protein (C4-bp) and is cleaved by C3b/C4b inactivator (I). hydrazine 36-40 complement component 4 binding protein alpha Homo sapiens 126-131 6976993-3 1982 We report here that C4 treated with N2H4 or KSCN or frozen-thawed, unlike native C4, forms a complex with C4-binding protein (C4-bp) and is cleaved by C3b/C4b inactivator (I). hydrazine 36-40 complement factor I Homo sapiens 151-170 6276242-0 1982 Spin-labelling of DNA with hydrazine mustard spin label (HMSL). hydrazine 27-36 spindlin 1 Homo sapiens 0-4 6276242-2 1982 The hydrazine mustard spin label (HMSL), recently synthesized in our laboratory (Raikova, 1977) was used for spin-labelling of DNA. hydrazine 4-13 spindlin 1 Homo sapiens 22-26 6276242-2 1982 The hydrazine mustard spin label (HMSL), recently synthesized in our laboratory (Raikova, 1977) was used for spin-labelling of DNA. hydrazine 4-13 spindlin 1 Homo sapiens 109-113 7394777-0 1980 Effects of hydrazine and its derivatives on ornithine decarboxylase synthesis, activity, and inactivation. hydrazine 11-20 ornithine decarboxylase 1 Homo sapiens 44-67 6252784-2 1980 Hydrazine (10--20 MM), added to the bladder"s serosal bath, reversibly enhanced the effect of both low and saturating levels of vasopressin on osmotic water flow, without increasing urea permeability. hydrazine 0-9 arginine vasopressin Homo sapiens 128-139 6252784-5 1980 Hydrazine increased luminal membrane aggregate frequency in vasopressin-treated tissues examined by freeze-fracture electron microscopy. hydrazine 0-9 arginine vasopressin Homo sapiens 60-71 6252784-6 1980 Hydrazine increased both basal and vasopressin-stimulated adenylate cyclase activity. hydrazine 0-9 arginine vasopressin Homo sapiens 35-46 6252784-7 1980 We could measure no effect of hydrazine on cAMP content; however hydrazine did increase the protein kinase activity ratio (-cAMP/+cAMP) in vasopressin-treated tissues, suggesting that the kinase activity ratio is more sensitive than cAMP content as an index of cAMP-related function in the bladder. hydrazine 65-74 arginine vasopressin Homo sapiens 139-150 7445522-14 1980 The cytochrome P-450 mediated oxidation of methylformylhydrazine to a hydroxylamine derivative and further to a nitrosamide, is discussed in relation to its importance for the biological action of the hydrazine. hydrazine 55-64 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 4-20 7411249-3 1980 Aminooxyacetic acid (AOAA) and hydrazine administration increased the GABA content and inhibited the GABA degrading enzyme, GABA transaminase in retina. hydrazine 31-40 4-aminobutyrate aminotransferase Rattus norvegicus 124-141 6244265-5 1980 Carbonyl reagents, such as borohydride, hydrazine, and benzhydrazide, reacted with myeloperoxidase, causing blue shifts in its absorption spectrum. hydrazine 40-49 myeloperoxidase Homo sapiens 83-98 6244265-7 1980 When hydrazine was added to cyanide complex I of myeloperoxidase the complex was converted to the hydrazine-enzyme compound. hydrazine 5-14 myeloperoxidase Homo sapiens 49-64 6244265-7 1980 When hydrazine was added to cyanide complex I of myeloperoxidase the complex was converted to the hydrazine-enzyme compound. hydrazine 98-107 myeloperoxidase Homo sapiens 49-64 6785574-11 1980 Thus it is apparent that brain MAO also contains cysteinyl-flavin at the active center and therefore it is expected that acetylenic as well as hydrazine inhibitors form the same linkage with the flavin moiety as that formed with enzyme from peripheral tissues. hydrazine 143-152 monoamine oxidase A Rattus norvegicus 31-34 499103-1 1979 Rat thyroid monoamine oxidase (MAO) was inhibited by the non-hydrazine derivatives paragyline and tranylcypromine to a higher degree than the hydrazine derivative iproniazide. hydrazine 61-70 monoamine oxidase A Rattus norvegicus 12-29 392306-1 1979 The effect of exogenous spermine tetrahydrochloride (0.5 mg/ml) on hydrazine- and nitrous acid-induced forward mutation to canavanine resistance (CAN1 leads to can1, normal to defective arginine permease) was examined in stationary-phase haploid Saccharomyces cerevisiae. hydrazine 67-76 arginine permease CAN1 Saccharomyces cerevisiae S288C 146-150 392306-1 1979 The effect of exogenous spermine tetrahydrochloride (0.5 mg/ml) on hydrazine- and nitrous acid-induced forward mutation to canavanine resistance (CAN1 leads to can1, normal to defective arginine permease) was examined in stationary-phase haploid Saccharomyces cerevisiae. hydrazine 67-76 arginine permease CAN1 Saccharomyces cerevisiae S288C 160-164 499103-1 1979 Rat thyroid monoamine oxidase (MAO) was inhibited by the non-hydrazine derivatives paragyline and tranylcypromine to a higher degree than the hydrazine derivative iproniazide. hydrazine 61-70 monoamine oxidase A Rattus norvegicus 31-34 499103-1 1979 Rat thyroid monoamine oxidase (MAO) was inhibited by the non-hydrazine derivatives paragyline and tranylcypromine to a higher degree than the hydrazine derivative iproniazide. hydrazine 142-151 monoamine oxidase A Rattus norvegicus 12-29 499103-1 1979 Rat thyroid monoamine oxidase (MAO) was inhibited by the non-hydrazine derivatives paragyline and tranylcypromine to a higher degree than the hydrazine derivative iproniazide. hydrazine 142-151 monoamine oxidase A Rattus norvegicus 31-34 141946-3 1977 The nature of the binding of the inhibitor to trypsin or plasmin was studied by the chemical treatment of the enzyme-inhibitor complex with 7.5 M hydrazine at pH 10.0. hydrazine 146-155 plasminogen Homo sapiens 57-64 631323-3 1978 The synthesis of some 3-hydrazino-6-monoalkylaminopyridazines (VIII) by reaction of 3,6-dichloropyridazine with various N-monoalkylbenzylamines, followed by reaction with hydrazine and final debenzylation in an acidic medium, is described. hydrazine 171-180 cytochrome c oxidase subunit 8A Homo sapiens 63-67 18962187-3 1977 Iron is then recovered by elution with 0.15M hydrochloric acid-1% hydrazine solution. hydrazine 66-75 mediator complex subunit 25 Homo sapiens 58-64 1094115-1 1975 Des(Pro9,Gly10)-LH-RH ethylamide, des(Pro9,Gly10)-LH-RH butylamide, desGly10-LH-RH 2-aminoethylamide, and desGly10-LH-RH hydrazide were synthesized by a solid-phase method involving cleavage of protected peptide intermediates from their resin support by reaction with ethylamine, butylamine, ethylenediamine, and hydrazine, respectively. hydrazine 313-322 gonadotropin releasing hormone 1 Rattus norvegicus 16-21 939760-2 1976 One involved identification of an amino-terminus of the C-peptide obtained by selective cleavage with hydrazine of the kynurenyl peptide linkage in oxidized lysozyme. hydrazine 102-111 insulin Homo sapiens 56-65 13991-1 1977 Previous studies have shown that a group of nitrogen catabolic enzymes including xanthine dehydrogenase, purine nucleoside phosphorylase, and tyrosine aminotransferase are all increased in chick liver by dietary protein as well as single amino acids (e.g. methionine) and certain antimetabolites (e.g. hydrazine). hydrazine 302-311 xanthine dehydrogenase Gallus gallus 81-103 56780-3 1976 A protein in cobra serum reacts strongly with antiserum to the venom factor and the former protein, like human C3, is converted by incubation of cobra serum with endotoxin, hydrazine, or simple storage at 37 degrees C. Incubation of cobra venom factor with cobra serum destroys the C3 cleaving activity of the venom factor in human serum, whereas human C3b inactivator is ineffective. hydrazine 173-182 complement C3 Homo sapiens 111-113 5603511-0 1967 [Effect of hydrazine and isonicotinic acid therapy on the prothrombin, hemorrhage and blood coagulation time]. hydrazine 11-20 coagulation factor II, thrombin Homo sapiens 58-69 4753930-0 1973 Effect of nitrogen and of catalase on hydroxylamine and hydrazine mutagenesis. hydrazine 56-65 catalase Homo sapiens 26-34 5555697-0 1971 Hydrazine-induced inhibition of amino acid incorporation into rat liver protein. hydrazine 0-9 Yip1 interacting factor homolog A, membrane trafficking protein Rattus norvegicus 66-79 5889569-0 1965 [Inhibitory action of certain hydrazine derivatives on rat liver catalase]. hydrazine 30-39 catalase Rattus norvegicus 65-74 13697075-0 1960 [Amino nitrogen balance in amino-fusin therapy of severe acute nutrition disorders in infants]. hydrazine 1-15 C-X-C motif chemokine receptor 4 Homo sapiens 33-38 24546700-0 1961 Acute toxicity of a mixed hydrazine fuel (MHF-1). hydrazine 26-35 centromere protein S Homo sapiens 42-47 14392887-0 1955 [The effects of hydrazine and guanylhydrazone derivatives on the activity of monoamine oxidase, diamine oxidase, DOPA decarboxylase and histidine decarboxylase]. hydrazine 16-25 amine oxidase copper containing 1 Homo sapiens 96-111 13806127-0 1960 Inhibition of diamine oxidase in vivo by hydrazine derivatives. hydrazine 41-50 amine oxidase copper containing 1 Homo sapiens 14-29 16590515-0 1959 PYRIDOXAL KINASE OF HUMAN BRAIN AND ITS INHIBITION BY HYDRAZINE DERIVATIVES. hydrazine 54-63 pyridoxal kinase Homo sapiens 0-16 14392887-0 1955 [The effects of hydrazine and guanylhydrazone derivatives on the activity of monoamine oxidase, diamine oxidase, DOPA decarboxylase and histidine decarboxylase]. hydrazine 16-25 dopa decarboxylase Homo sapiens 113-131 34000185-0 2021 Boosting Hydrazine Oxidation Reaction on CoP/Co Mott-Schottky Electrocatalyst through Engineering Active Sites. hydrazine 9-18 caspase recruitment domain family member 16 Homo sapiens 41-44 13107647-0 1953 Action of insulin on blood amino nitrogen. hydrazine 27-41 insulin Homo sapiens 10-17 19873017-12 1937 Hydrazine or pyridine and hydrosulfite convert catalase into hemochromogens containing ferrous iron. hydrazine 0-9 catalase Homo sapiens 47-55 34000185-5 2021 A shown by with structural characterization and density functional theory (DFT) calculations, the interfaces between CoP/Co nanoparticles not only provide the active sites of HzOR but also promote the multistep dehydrogenation reaction of N2H4, thus enhancing the HzOR activity. hydrazine 239-243 caspase recruitment domain family member 16 Homo sapiens 117-120 33094670-1 2021 INTRODUCTION: The N-acetylation polymorphism has been the subject of comprehensive reviews describing the role of arylamine N-acetyltransferase 2 (NAT2) in the metabolism of numerous aromatic amine and hydrazine drugs. hydrazine 202-211 N-acetyltransferase 2 Homo sapiens 114-145 34036470-8 2021 Molecular dynamics (MD) simulation was performed for 100 ns to validate the stability behavior of hydrazine derivatives with the dual specificity threonine tyrosine kinase (TTK) protein. hydrazine 98-107 TTK protein kinase Homo sapiens 146-171 34036470-8 2021 Molecular dynamics (MD) simulation was performed for 100 ns to validate the stability behavior of hydrazine derivatives with the dual specificity threonine tyrosine kinase (TTK) protein. hydrazine 98-107 TTK protein kinase Homo sapiens 173-176 33999084-5 2021 NiO-CoO-NW/FTO showed enhanced electro-oxidation for hydrazine at all concentrations tested. hydrazine 53-62 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 11-14 33999084-9 2021 Besides, the NiO-CoO-NW/FTO electrodes showed significant selectivity towards hydrazine upon testing cross-sensitivity to other common interfering molecules. hydrazine 78-87 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 24-27 33999084-10 2021 This strategy of using NiO-CoO-NW/FTO electrodes prepared via AACVD has great potential for the direct determination of hydrazine in environmental sensing applications. hydrazine 120-129 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 34-37 33783134-7 2021 Density functional theory calculations of the reaction mechanism over the material reveal that the Co(II) sites on G(CN) Co can efficiently interact with hydrazine molecules and promote the N H bond-dissociation steps involved in the HzOR. hydrazine 154-163 mitochondrially encoded cytochrome c oxidase II Homo sapiens 99-105 33560846-1 2021 In low-temperature flash photolysis of NH3/O2/N2 mixtures, the NH2 consumption rate and the product distribution is controlled by the reactions NH2 + HO2 products (R1), NH2 + H (+M) NH3 (+M) (R2), and NH2 + NH2 (+M) N2H4 (+M) (R3). hydrazine 222-226 heme oxygenase 2 Homo sapiens 150-153 33644570-4 2021 The sensor responded linearly with increasing concentration of hydrazine from 0.03 to 500.0 muM with a higher sensitivity (0.073 muA muM-1) and lower limit of detection (LOD, 0.015 muM). hydrazine 63-72 PWWP domain containing 3A, DNA repair factor Homo sapiens 133-138 33679162-8 2021 Amperometric current responses in the low hydrazine concentration range of 0.25-13 microM at the AuNPs/CNT/poly(PP)/GCE. hydrazine 42-51 aminomethyltransferase Homo sapiens 116-119 33094670-1 2021 INTRODUCTION: The N-acetylation polymorphism has been the subject of comprehensive reviews describing the role of arylamine N-acetyltransferase 2 (NAT2) in the metabolism of numerous aromatic amine and hydrazine drugs. hydrazine 202-211 N-acetyltransferase 2 Homo sapiens 147-151 32711085-3 2020 Furthermore, it reacted with hydrazine hydrate and phenyl hydrazine individually to afford the corresponding 1,4-bis[(2-(1H-pyrazolyl)benzofuran-5-yl)methyl]piperazines. hydrazine 29-46 Bis protein Escherichia coli 113-116 33161253-1 2020 In this paper, based on molecular hybridization, a series of [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazine was synthesized and their antiproliferative activities against 5 cancer cell lines (MGC-803, PC3, PC9, EC9706 and SMMC-7721) were evaluated. hydrazine 117-126 proprotein convertase subtilisin/kexin type 1 Homo sapiens 220-223 33161253-1 2020 In this paper, based on molecular hybridization, a series of [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazine was synthesized and their antiproliferative activities against 5 cancer cell lines (MGC-803, PC3, PC9, EC9706 and SMMC-7721) were evaluated. hydrazine 117-126 proprotein convertase subtilisin/kexin type 9 Homo sapiens 225-228 33255958-3 2020 The authors are mainly focused on the common analytes in gas sensors such as hydrogen sulfide, ammonia, and electrochemical sensors including non-enzymatic glucose, hydrazine, dopamine, and hydrogen peroxide. hydrazine 165-174 gastrin Homo sapiens 57-60 32717907-5 2020 When compared with the previously reported hydrazone series, hydrazine but not hydrazide analogs showed similarly potent inhibitory activity on VIM-type enzymes, especially VIM-2 and VIM-4, with Ki values in the micromolar to submicromolar range. hydrazine 61-70 vimentin Homo sapiens 144-147 32498835-5 2020 The experiments of sensing indicated that probes C1 and C3 possessed the sequentially detecting abilities for hydrazine with high sensitivity, specificity as well as an extremely low detection limit (55.1 nM), which was due to blocking of AIE process of probes C1 and C3 by special chemical reaction (-CHN- moiety transformed into -CH2-NH- group) after hydrazine addition, resulting in the increase in water solubility and a weak emission in aqueous media. hydrazine 110-119 heterogeneous nuclear ribonucleoprotein C Homo sapiens 49-58 32498835-5 2020 The experiments of sensing indicated that probes C1 and C3 possessed the sequentially detecting abilities for hydrazine with high sensitivity, specificity as well as an extremely low detection limit (55.1 nM), which was due to blocking of AIE process of probes C1 and C3 by special chemical reaction (-CHN- moiety transformed into -CH2-NH- group) after hydrazine addition, resulting in the increase in water solubility and a weak emission in aqueous media. hydrazine 110-119 heterogeneous nuclear ribonucleoprotein C Homo sapiens 261-270 32498835-5 2020 The experiments of sensing indicated that probes C1 and C3 possessed the sequentially detecting abilities for hydrazine with high sensitivity, specificity as well as an extremely low detection limit (55.1 nM), which was due to blocking of AIE process of probes C1 and C3 by special chemical reaction (-CHN- moiety transformed into -CH2-NH- group) after hydrazine addition, resulting in the increase in water solubility and a weak emission in aqueous media. hydrazine 353-362 heterogeneous nuclear ribonucleoprotein C Homo sapiens 49-58 32498835-5 2020 The experiments of sensing indicated that probes C1 and C3 possessed the sequentially detecting abilities for hydrazine with high sensitivity, specificity as well as an extremely low detection limit (55.1 nM), which was due to blocking of AIE process of probes C1 and C3 by special chemical reaction (-CHN- moiety transformed into -CH2-NH- group) after hydrazine addition, resulting in the increase in water solubility and a weak emission in aqueous media. hydrazine 353-362 heterogeneous nuclear ribonucleoprotein C Homo sapiens 261-270 32498835-7 2020 For biological application, probes C1 and C3 presented a good bio-imaging performance and showed the similar fluorescence quenching after adding hydrazine. hydrazine 145-154 heterogeneous nuclear ribonucleoprotein C Homo sapiens 35-44 32717907-5 2020 When compared with the previously reported hydrazone series, hydrazine but not hydrazide analogs showed similarly potent inhibitory activity on VIM-type enzymes, especially VIM-2 and VIM-4, with Ki values in the micromolar to submicromolar range. hydrazine 61-70 vimentin 2, pseudogene Homo sapiens 173-178 32035352-7 2020 Amperometry was employed for constructing the quantitative calibration curve; the steady-state current originating from hydrazine oxidation was proportional to the analytical concentration ranging from 0.1 muM to 200 muM, with the detection limit of 16 nM. hydrazine 120-129 latexin Homo sapiens 206-209 31818652-6 2020 The HSP-RDL vesicle probe exhibited high sensitivity and selectivity for hydrazine recognition in presence of various competitive species such as cations, anions, and neutral species. hydrazine 73-82 LEO1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 8-11 32035352-7 2020 Amperometry was employed for constructing the quantitative calibration curve; the steady-state current originating from hydrazine oxidation was proportional to the analytical concentration ranging from 0.1 muM to 200 muM, with the detection limit of 16 nM. hydrazine 120-129 latexin Homo sapiens 217-220 31789325-4 2020 Additionally, the DPT probe exhibits a low detection limit (5 x 10-8 M), applicable to the physiological pH range (3-12), a broad linear response range for hydrazine concentrations between 0 and 34 muM and a large Stokes shift (147 nm) for hydrazine detection in aqueous solution. hydrazine 156-165 latexin Homo sapiens 198-201 31759882-6 2020 There was a linear relationship between the fluorescence intensity and the concentration of hydrazine (0.14-120.00 muM). hydrazine 92-101 latexin Homo sapiens 115-118 32090224-0 2020 Pulse radiolysis study on the reactivity of NO3 radical toward uranous(iv), hydrazinium nitrate and hydroxyl ammonium nitrate at room temperature and at 45 C. Concentrated nitric acid solutions subjected to radiation produce radicals of extreme importance in the reprocessing of spent nuclear fuel. hydrazine 77-96 NBL1, DAN family BMP antagonist Homo sapiens 44-47 31597427-0 2019 The BODIPY-based chemosensor for fluorometric/colorimetric dual channel detection of RDX and PA. A fluorometric/colorimetric dual-channel chemosensor based on a hydrazine-substituted BODIPY probe has been successfully fabricated for the detection of RDX and PA. hydrazine 161-170 radixin Homo sapiens 85-88 31319274-4 2019 In addition, the detection limit was as low as 3.4 ppb, and the fluorescence intensity at 654 nm showed a satisfactory linearity with the concentration range of hydrazine from 0 to 120 muM. hydrazine 161-170 latexin Homo sapiens 185-188 31450471-5 2019 Detection of hydrazine as hydrazinium ion using electrochemical detector was linear between 10 muM and 4 mM, with LOD and LOQ values of 3 muM and 10 muM, respectively. hydrazine 13-22 latexin Homo sapiens 95-98 31450471-5 2019 Detection of hydrazine as hydrazinium ion using electrochemical detector was linear between 10 muM and 4 mM, with LOD and LOQ values of 3 muM and 10 muM, respectively. hydrazine 13-22 latexin Homo sapiens 138-141 31450471-5 2019 Detection of hydrazine as hydrazinium ion using electrochemical detector was linear between 10 muM and 4 mM, with LOD and LOQ values of 3 muM and 10 muM, respectively. hydrazine 13-22 latexin Homo sapiens 138-141 31505333-5 2019 These electrodes further display excellent catalytic activity towards the urea oxidation reaction (UOR) and hydrazine oxidation reaction (HzOR) with potentials lower than 1.32 V (vs RHE) and 0.06 V (vs RHE), respectively. hydrazine 108-117 factor interacting with PAPOLA and CPSF1 Homo sapiens 182-185 31505333-5 2019 These electrodes further display excellent catalytic activity towards the urea oxidation reaction (UOR) and hydrazine oxidation reaction (HzOR) with potentials lower than 1.32 V (vs RHE) and 0.06 V (vs RHE), respectively. hydrazine 108-117 factor interacting with PAPOLA and CPSF1 Homo sapiens 202-205 31597427-0 2019 The BODIPY-based chemosensor for fluorometric/colorimetric dual channel detection of RDX and PA. A fluorometric/colorimetric dual-channel chemosensor based on a hydrazine-substituted BODIPY probe has been successfully fabricated for the detection of RDX and PA. hydrazine 161-170 radixin Homo sapiens 250-253 31627477-4 2019 In our recent report, we disclosed a ratiometric type fluorescent probe, called HyP-1, for the detection of hydrazine, which is based on ortho-methoxy-methyl-ether (o-MOM) moiety assisted hydrazone-formation of the donor (D)-acceptor (A) type naphthaldehyde backbone. hydrazine 108-117 phosphate regulating endopeptidase homolog X-linked Homo sapiens 80-85 31455959-0 2019 Mechanisms of ammonia and hydrazine synthesis on eta-Mn3N2-(100) surfaces. hydrazine 26-35 endothelin receptor type A Homo sapiens 49-52 31455959-2 2019 In this computational study, dispersion-corrected Density Functional Theory (DFT) theory was used to calculate the various mechanistic pathways for ammonia and hydrazine synthesis on eta-Mn3N2-(100) surfaces. hydrazine 160-169 endothelin receptor type A Homo sapiens 183-186 31455959-5 2019 It is anticipated that these findings are significant in developing new catalysts for hydrazine synthesis using eta-Mn3N2(100) catalysts. hydrazine 86-95 endothelin receptor type A Homo sapiens 112-115 31460547-0 2019 Retraction: Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen. hydrazine 155-164 Rh associated glycoprotein Homo sapiens 69-72 31460547-1 2019 Retraction of "Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen" by Chun Li et al., Nanoscale, 2016, 8, 7043-7055. hydrazine 158-167 Rh associated glycoprotein Homo sapiens 72-75 31361945-2 2019 The use of hydrazine monohydrate as a reagent to prepare chemically engineered extracts can lead to semisynthetic compounds that contain the portion N-N, a fragment rarely found in natural products and present in some tyrosinase inhibitors. hydrazine 11-32 tyrosinase Homo sapiens 218-228 31361945-3 2019 Here, we report the tyrosinase inhibition screening of a series of chemically engineered extracts that are diversified by reaction with hydrazine. hydrazine 136-145 tyrosinase Homo sapiens 20-30 30732777-3 2019 1% CNF and 4% CNC significantly retarded free amino nitrogen (FAN) diffusion (23% and 50% respectively) mainly due to high viscosity. hydrazine 46-60 protein kinase cAMP-dependent type I regulatory subunit alpha Homo sapiens 14-17 31376963-10 2019 Leaching with 1 M citrate, 0.2 M N2H4, at pH = 5, using sodium hydroxide (NaOH) at solid:liquid (S:L) ratio of 20 g L-1, yielded a remarkably high In recovery of 98.9% after 16.6 h. hydrazine 33-37 L1 cell adhesion molecule Homo sapiens 116-119 31193469-2 2019 In the present work, a natural product anisaldehyde was treated with hydrazine and 3,5-dichloroaniline to synthesize their Schiff bases, ASB1 and ASB2, which were assessed for various bioactivities. hydrazine 69-78 ankyrin repeat and SOCS box containing 1 Homo sapiens 137-141 31193469-2 2019 In the present work, a natural product anisaldehyde was treated with hydrazine and 3,5-dichloroaniline to synthesize their Schiff bases, ASB1 and ASB2, which were assessed for various bioactivities. hydrazine 69-78 ankyrin repeat and SOCS box containing 2 Homo sapiens 146-150 30857888-4 2019 It inhibits gamma-aminobutyric acid (GABA) transaminase, resulting in elevated brain GABA levels, inhibits both MAO and primary amine oxidase and, due to its hydrazine-containing structure, reacts chemically to sequester a number of reactive aldehydes (e.g. acrolein and 4-hydroxy-2-nonenal) proposed to be implicated in oxidative stress in a number of neurodegenerative disorders. hydrazine 158-167 4-aminobutyrate aminotransferase Rattus norvegicus 12-55 31397460-2 2019 Alternatively, when (9H-fluoren-9-ylidene)hydrazone is employed several products were isolated including 1,2-di(9H-fluoren-9-ylidene)hydrazone, the 2 : 1 borane adduct of NH2-NH2 and the 1-(diarylboraneyl)-2-(9H-fluoren-9-ylidene)hydrazone in which one ArH group has been eliminated. hydrazine 171-178 low density lipoprotein receptor adaptor protein 1 Homo sapiens 253-256 31310268-2 2019 Reaction of PhHNNH2 at a 4 : 1 mole ratio with the bis-(pyrazolate)pyridyl pincer ligated reducing agent [CrIIL]2 gives prompt conversion to [CrL2(PhNH2)2(mu-PhHNN)], with release of NH3 and C6H6, a new disproportionation of the hydrazine, with trapping of PhHNN as its dianion, bridging the two chromium centers. hydrazine 229-238 cytokine receptor like factor 2 Homo sapiens 142-146 31281021-3 2019 Here, a completely regioselective route to tetrahydro-pyrazolopyridine pendrin inhibitors based on 1,3-diketone and substituted hydrazine condensation was been developed. hydrazine 128-137 solute carrier family 26 member 4 Homo sapiens 71-78 31944030-2 2019 Here, we demonstrate the 1,3-dipolar cycloaddition between PAMY and 1,4-diphenylbut-2-yne-1,4-dione and the subsequent condensation reaction with hydrazine, which led to unique N-PAHs with a phenyl-substituted pyrrolopyridazine core (PP-1 and PP-2). hydrazine 146-155 inorganic pyrophosphatase 1 Homo sapiens 234-238 31944030-2 2019 Here, we demonstrate the 1,3-dipolar cycloaddition between PAMY and 1,4-diphenylbut-2-yne-1,4-dione and the subsequent condensation reaction with hydrazine, which led to unique N-PAHs with a phenyl-substituted pyrrolopyridazine core (PP-1 and PP-2). hydrazine 146-155 neuropeptide Y receptor Y6 (pseudogene) Homo sapiens 243-247 30615436-7 2019 Interestingly, monomeric 1 underwent transformation to dimeric 2 in the presence of a strong reducing agent, hydrazine hydrate, and the reverse process, i.e., conversion of dimeric 2 to 1, took place under the influence of external coordinating agent ArNO. hydrazine 109-126 cytohesin 2 Homo sapiens 251-255 30517741-7 2019 Together, these data demonstrate that hydrazine upregulates ALAS1, whereas PIH downregulates FECH, suggesting that the metabolites of isoniazid mediate its disruption of heme biosynthesis by contributing to protoporphyrin IX accumulation. hydrazine 38-47 5'-aminolevulinate synthase 1 Homo sapiens 60-65 30321639-8 2019 For the hydrazine treated samples, we observe a maximum n-type power factor of 10.2 muW cm-1 K-2 for the CNFs produced in the same way which is an 11.0-fold increase to the hydrazine-treated CNFs with 0% lignin. hydrazine 8-17 RBPJ pseudogene 3 Homo sapiens 93-96 30321639-8 2019 For the hydrazine treated samples, we observe a maximum n-type power factor of 10.2 muW cm-1 K-2 for the CNFs produced in the same way which is an 11.0-fold increase to the hydrazine-treated CNFs with 0% lignin. hydrazine 173-182 RBPJ pseudogene 3 Homo sapiens 93-96 30150984-3 2018 NOX2 activation is triggered by protein kinase C agonists (e.g., phorbol esters, transition metal ions), redox mediators (e.g., paraquat) or formyl peptide receptor (FPR) agonists (e.g., aromatic hydrazine derivatives). hydrazine 196-205 cytochrome b-245 beta chain Homo sapiens 0-4 30431044-6 2018 Among the reported carbocatalysts for nitrobenzene reduction using hydrazine hydrate, NSHC shows the highest turnover frequency value of 4.89 h-1. hydrazine 67-76 SHC adaptor protein 3 Homo sapiens 86-90 29776549-6 2018 Meanwhile, the sensor also shows a linear response to N2H4 in the range of 0.006-0.061 muM and 0.061-611.111 muM with a high sensitivity of 20.1 muA/muM cm2 in low concentration range as well as a very low LOD as 5.3 nM (S/N = 3). hydrazine 54-58 latexin Homo sapiens 87-90 29776549-6 2018 Meanwhile, the sensor also shows a linear response to N2H4 in the range of 0.006-0.061 muM and 0.061-611.111 muM with a high sensitivity of 20.1 muA/muM cm2 in low concentration range as well as a very low LOD as 5.3 nM (S/N = 3). hydrazine 54-58 latexin Homo sapiens 109-112 29776549-6 2018 Meanwhile, the sensor also shows a linear response to N2H4 in the range of 0.006-0.061 muM and 0.061-611.111 muM with a high sensitivity of 20.1 muA/muM cm2 in low concentration range as well as a very low LOD as 5.3 nM (S/N = 3). hydrazine 54-58 latexin Homo sapiens 109-112 30961430-2 2019 These series of compounds were designed through the reaction of sodium 2-cyano-3-oxo-3-(4-substitutedphenylamino)prop-1-ene-1,1-bis(thiolate) salts 2 with hydrazine hydrate in ethanol at room temperature to give the corresponding sodium 5-amino-4-(substitutedphenylcarbamoyl)-1H-pyrazole-3-thiolates 3a-d. hydrazine 155-172 PROP paired-like homeobox 1 Homo sapiens 113-119 30149019-1 2018 N-acetyltransferase 2 (NAT2) catalyzes the biotransformation of numerous arylamine and hydrazine drugs and carcinogens. hydrazine 87-96 N-acetyltransferase 2 Homo sapiens 0-21 30149019-1 2018 N-acetyltransferase 2 (NAT2) catalyzes the biotransformation of numerous arylamine and hydrazine drugs and carcinogens. hydrazine 87-96 N-acetyltransferase 2 Homo sapiens 23-27 30320253-7 2018 The biosensor showed a highly selective H2O2 signal with current sensitivity and detection limit values 0.1303 muA muM-1 and 990 nM, respectively, with tolerable interference from the common biochemicals like dissolved oxygen, cysteine, ascorbic acid, glucose, xanthine, hypoxanthine, uric acid, and hydrazine. hydrazine 300-309 PWWP domain containing 3A, DNA repair factor Homo sapiens 115-120 29971283-1 2018 Three high-performance hydrazine sensing devices have been developed based on donor-acceptor perylenediimides (PDIs) with strongly electron-donating piperidinyl (PDI-PY), pyrrolidinyl (PDI-PI) and n-hexylamino (PDI-HE) as substituents at the perylene core. hydrazine 23-32 peptidyl arginine deiminase 1 Homo sapiens 111-114 30035546-2 2018 The use of hydrazine as a bridging linkage between pyrrole and N-heteroarenes enables the binding of two BF2 units to provide sufficient rigidity of the unsymmetric core skeleton. hydrazine 11-20 forkhead box G1 Homo sapiens 105-108 29858157-3 2018 Our results indicate that C-terminal flexible linkers play an important role in KOR activity compared to that of the other cyclic biphalin analogues with a hydrazine linker. hydrazine 156-165 opioid receptor kappa 1 Homo sapiens 80-83 29971283-1 2018 Three high-performance hydrazine sensing devices have been developed based on donor-acceptor perylenediimides (PDIs) with strongly electron-donating piperidinyl (PDI-PY), pyrrolidinyl (PDI-PI) and n-hexylamino (PDI-HE) as substituents at the perylene core. hydrazine 23-32 peptidyl arginine deiminase 1 Homo sapiens 162-165 29971283-1 2018 Three high-performance hydrazine sensing devices have been developed based on donor-acceptor perylenediimides (PDIs) with strongly electron-donating piperidinyl (PDI-PY), pyrrolidinyl (PDI-PI) and n-hexylamino (PDI-HE) as substituents at the perylene core. hydrazine 23-32 peptidyl arginine deiminase 1 Homo sapiens 162-165 29971283-2 2018 These PDI devices, compared with reported PDI molecules, displayed 1-2 orders of magnitude higher sensitivity, short response/recovery time and a lower detection limit towards hydrazine vapour. hydrazine 176-185 peptidyl arginine deiminase 1 Homo sapiens 6-9 29971283-2 2018 These PDI devices, compared with reported PDI molecules, displayed 1-2 orders of magnitude higher sensitivity, short response/recovery time and a lower detection limit towards hydrazine vapour. hydrazine 176-185 peptidyl arginine deiminase 1 Homo sapiens 42-45 29874065-2 2018 It undergoes spin-crossover (SCO) upon deprotonation of the hydrazine-based terpyridine-like ligand. hydrazine 60-69 spindlin 1 Homo sapiens 13-17 29969126-0 2018 Expression of concern: Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen. hydrazine 166-175 Rh associated glycoprotein Homo sapiens 80-83 29969126-1 2018 Expression of concern for "Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen" by Chun Li et al., Nanoscale, 2016, 8, 7043-7055. hydrazine 170-179 Rh associated glycoprotein Homo sapiens 84-87 29401642-6 2018 Under the optimal conditions of a pH of 6.0 and a hydrazine concentration of 1 mM, a detection limit of 0.28 ng mL-1 and a linearity of 0-10 ng mL-1 were obtained. hydrazine 50-59 L1 cell adhesion molecule Mus musculus 112-116 29454300-1 2018 In this report, a facile, efficient and low cost electrochemical sensor based on bimetallic Au-Cu nanoparticles supported on P nanozeolite modified carbon paste electrode (Au-Cu/NPZ/CPE) was constructed and its efficiency for determination of hydrazine in trace level was studied. hydrazine 243-252 carboxypeptidase E Homo sapiens 182-185 29454300-5 2018 The electrochemical properties of hydrazine at the surface of Au-Cu/NPZ/CPE was evaluated using cyclic voltammetry (CV), amperometry, and chronoamperometry methods in 0.1 M phosphate buffer solution (PBS). hydrazine 34-43 carboxypeptidase E Homo sapiens 72-75 30090308-0 2018 Large-bite diboranes for the mu(1,2) complexation of hydrazine and cyanide. hydrazine 53-62 glutathione S-transferase mu 1 Homo sapiens 29-35 29268232-5 2018 The detection limit of the probe for hydrazine was calculated to be 0.057muM which was lower than the EPA standard (0.320muM). hydrazine 37-46 latexin Homo sapiens 73-76 29253824-7 2018 PVP and PEG 1% each together provide better size control over silver nanoparticle synthesis using 0.4 M hydrazine as reductant, which provides relatively regular morphology in comparison to their individual application. hydrazine 104-113 mesoderm specific transcript Homo sapiens 8-13 29782672-4 2018 Herein, monolayered FePS3 quantum sheets (QSs) are systematically obtained, whose diameters range from 4-8 nm, through exfoliation of the bulk in hydrazine solution. hydrazine 146-155 sodium voltage-gated channel alpha subunit 11 Homo sapiens 20-25 29265682-1 2018 CdS sheet-rGO nanocomposite as a heterogeneous photocatalyst enables visible-light-induced photocatalytic reduction of aromatic, heteroaromatic, aliphatic and sulfonyl azides to the corresponding amines using hydrazine hydrate as a reductant. hydrazine 209-226 CDP-diacylglycerol synthase 1 Homo sapiens 0-3 29401642-6 2018 Under the optimal conditions of a pH of 6.0 and a hydrazine concentration of 1 mM, a detection limit of 0.28 ng mL-1 and a linearity of 0-10 ng mL-1 were obtained. hydrazine 50-59 L1 cell adhesion molecule Mus musculus 144-148 28850211-4 2017 The Ru-WO3-modified electrodes were found to show extraordinary electrochemical performances for sensitive and selective detection of N2H4 with a desirable wide linear range of 0.7-709.2 muM and a detection limit and sensitivity of 0.3625 muM and 4.357 muA muM-1 cm-2, respectively, surpassing other modified electrodes. hydrazine 134-138 PWWP domain containing 3A, DNA repair factor Homo sapiens 257-262 28915022-2 2017 The tetranuclear triple-stranded helicates, {CoII4L3}4-, are connected in 1 by sodium(I) ions and in 2 by sodium(I) and cobalt(II) ions (H4L results from the condensation reaction between 3-formylsalicylic acid and hydrazine). hydrazine 215-224 H4 clustered histone 7 Homo sapiens 137-140 28753459-3 2017 The elongation of the C-5 chain was achieved by the reaction of C-5 ester with hydrazine leading to C-5 carbohydrazides which were further used as building blocks for the synthesis of fifteen new compounds having diverse moieties. hydrazine 79-88 complement C5 Homo sapiens 22-25 28753459-3 2017 The elongation of the C-5 chain was achieved by the reaction of C-5 ester with hydrazine leading to C-5 carbohydrazides which were further used as building blocks for the synthesis of fifteen new compounds having diverse moieties. hydrazine 79-88 complement C5 Homo sapiens 64-67 28753459-3 2017 The elongation of the C-5 chain was achieved by the reaction of C-5 ester with hydrazine leading to C-5 carbohydrazides which were further used as building blocks for the synthesis of fifteen new compounds having diverse moieties. hydrazine 79-88 complement C5 Homo sapiens 64-67 30430943-8 2018 RESULTS: Compound 5 with bromo 5-bromo-isatin exhibited a remarkable hMAO-A inhibitory potential (7.473+-0.035 microM and the selectivity index of 0.14) revealing the impact of hybrid coumarin and 5- bromo-2-oxoindolin-3-yl ring with hydrazine linker on the hMAO-A active site. hydrazine 234-243 monoamine oxidase A Homo sapiens 69-75 29058431-5 2017 The synthesis of these complex diazenes was made possible through a new methodology for synthesis of aryl-alkyl diazenes using electronically attenuated hydrazine-nucleophiles for a silver-promoted addition to C3a-bromocyclotryptamines. hydrazine 153-162 complement C3 Homo sapiens 210-213 28930439-0 2017 Controlled Synthesis of MOF-Encapsulated NiPt Nanoparticles toward Efficient and Complete Hydrogen Evolution from Hydrazine Borane and Hydrazine. hydrazine 114-123 lysine acetyltransferase 8 Homo sapiens 24-27 28268018-5 2017 ELP-HA hydrogels were created through dynamic hydrazone bonds via the reaction between hydrazine-modified ELP (ELP-HYD) and aldehyde-modified HA (HA-ALD). hydrazine 87-96 nuclear receptor subfamily 5 group A member 1 Homo sapiens 0-3 28614742-11 2017 This study shows that binding with amino nitrogen compounds should be an important process for HBQs transformation and detoxification, which helps to better understand the fate of this typical DBP in surface water. hydrazine 35-49 D-box binding PAR bZIP transcription factor Homo sapiens 193-196 28523442-1 2017 Human N-acetyltransferase 2 (NAT2) catalyzes the N-acetylation of numerous aromatic amine drugs such as sulfamethazine (SMZ) and hydrazine drugs such as isoniazid (INH). hydrazine 129-138 N-acetyltransferase 2 Homo sapiens 6-27 28523442-1 2017 Human N-acetyltransferase 2 (NAT2) catalyzes the N-acetylation of numerous aromatic amine drugs such as sulfamethazine (SMZ) and hydrazine drugs such as isoniazid (INH). hydrazine 129-138 N-acetyltransferase 2 Homo sapiens 29-33 33041740-3 2017 Ex situ at room temperature, rapid gelation occurs through dynamic covalent hydrazone bonds by simply mixing two components: hydrazine-modified elastin-like protein (ELP) and aldehyde-modified hyaluronic acid. hydrazine 125-134 nuclear receptor subfamily 5 group A member 1 Homo sapiens 144-164 33041740-3 2017 Ex situ at room temperature, rapid gelation occurs through dynamic covalent hydrazone bonds by simply mixing two components: hydrazine-modified elastin-like protein (ELP) and aldehyde-modified hyaluronic acid. hydrazine 125-134 nuclear receptor subfamily 5 group A member 1 Homo sapiens 166-169 28268018-5 2017 ELP-HA hydrogels were created through dynamic hydrazone bonds via the reaction between hydrazine-modified ELP (ELP-HYD) and aldehyde-modified HA (HA-ALD). hydrazine 87-96 nuclear receptor subfamily 5 group A member 1 Homo sapiens 106-109 28268018-5 2017 ELP-HA hydrogels were created through dynamic hydrazone bonds via the reaction between hydrazine-modified ELP (ELP-HYD) and aldehyde-modified HA (HA-ALD). hydrazine 87-96 nuclear receptor subfamily 5 group A member 1 Homo sapiens 111-118 27916130-5 2017 Hydrazine was detected over a concentration range of 0.011-0.074 mug L-1 in 5 of 20 waste water samples. hydrazine 0-9 immunoglobulin kappa variable 1-16 Homo sapiens 69-72 27940234-2 2017 Specifically, we prepared iron doped polyacrylic hydrazide modified reduced graphene nanocomposites (Fe@RGO/PAH) by in-situ polymerization approach and subsequent a one-pot reaction with hydrazine. hydrazine 187-196 phenylalanine hydroxylase Homo sapiens 108-111 27750484-4 2017 Phenelzine (PZ) is a U.S. Food and Drug Administration-approved monoamine oxidase (MAO) inhibitor (MAO-I) used for treatment of refractory depression that possesses a hydrazine functional group recently discovered by other investigators to scavenge reactive carbonyls. hydrazine 167-176 monoamine oxidase A Rattus norvegicus 64-81 27750484-4 2017 Phenelzine (PZ) is a U.S. Food and Drug Administration-approved monoamine oxidase (MAO) inhibitor (MAO-I) used for treatment of refractory depression that possesses a hydrazine functional group recently discovered by other investigators to scavenge reactive carbonyls. hydrazine 167-176 monoamine oxidase A Rattus norvegicus 83-86 27750484-4 2017 Phenelzine (PZ) is a U.S. Food and Drug Administration-approved monoamine oxidase (MAO) inhibitor (MAO-I) used for treatment of refractory depression that possesses a hydrazine functional group recently discovered by other investigators to scavenge reactive carbonyls. hydrazine 167-176 monoamine oxidase A Rattus norvegicus 99-102 28221344-3 2017 Here we show that "reverse-polarity" (RP)-ABPP using clickable, nucleophilic hydrazine probes can capture and identify protein-bound electrophiles in cells. hydrazine 77-86 amyloid beta precursor protein Homo sapiens 42-46 27753199-3 2017 The probe could detect hydrazine quantitatively in the range of 40-500 muM with the detection limit of 2.9 muM. hydrazine 23-32 latexin Homo sapiens 71-74 27753199-3 2017 The probe could detect hydrazine quantitatively in the range of 40-500 muM with the detection limit of 2.9 muM. hydrazine 23-32 latexin Homo sapiens 107-110 27853051-1 2017 Since NAT2 single-nucleotide polymorphisms (SNPs) are responsible for the efficacy of arylamines and hydrazine drugs, defining the effects of these SNPs in various ethnicities is an important factor in the development of personalized medicine. hydrazine 101-110 N-acetyltransferase 2 Homo sapiens 6-10 28153281-4 2017 The quantification of cTnI was conducted based on amperometric signals from the catalytic reaction between hydrazine and H2O2. hydrazine 107-116 troponin I3, cardiac type Homo sapiens 22-26 27925692-6 2017 The ketone-modified myristoylated Arf1 could be further labeled by fluorophore-coupled hydrazine and subsequently visualized through fluorescence imaging. hydrazine 87-96 ADP ribosylation factor 1 Homo sapiens 34-38 28065657-4 2017 Comparison of four cleavable linkers indicated that the hydrazine-labile N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker was cleaved most efficiently to release photolabeled and affinity-captured presenilin-1 (PS1), the catalytic subunit of gamma-secretase. hydrazine 56-65 presenilin 1 Homo sapiens 210-222 28065657-4 2017 Comparison of four cleavable linkers indicated that the hydrazine-labile N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker was cleaved most efficiently to release photolabeled and affinity-captured presenilin-1 (PS1), the catalytic subunit of gamma-secretase. hydrazine 56-65 presenilin 1 Homo sapiens 224-227 27823671-0 2016 In situ hydrazine reduced silver colloid synthesis - Enhancing SERS reproducibility. hydrazine 8-17 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 63-67 28918431-0 2017 The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115. hydrazine 14-23 fibroblast growth factor receptor 1 Homo sapiens 106-141 29109756-2 2017 Utilizing a condensation reaction between carbonyls and a hydrazine moeity, we demonstrate that the fluorescent probe (Aldehydefluor-1) AF1 reacts with a range of reactive carbonyl species including formaldehyde, acetaldehyde, glyoxylic acid, and methyl glyoxal. hydrazine 58-67 interferon gamma receptor 2 Homo sapiens 136-139 27132006-3 2016 A nano-bioconjugate with hydrazine and a secondary antibody of HIF1alpha (sec-Ab2) attached on AuNPs reveals the immunoreaction at the sensor probe through the catalytic reduction of H2O2 by hydrazine at -0.35V vs. Ag/AgCl. hydrazine 191-200 hypoxia inducible factor 1 subunit alpha Homo sapiens 63-72 27075169-3 2016 The fluorescence response of the reagent based on its specific reaction with N2H4 is used for developing an in vitro assay for aminoacylase-1. hydrazine 77-81 aminoacylase 1 Homo sapiens 127-141 27171587-0 2016 Decay Mechanism of NO3( ) Radical in Highly Concentrated Nitrate and Nitric Acidic Solutions in the Absence and Presence of Hydrazine. hydrazine 124-133 NBL1, DAN family BMP antagonist Homo sapiens 19-22 27171587-1 2016 The decay mechanism of NO3( ) has been determined through a combination of experiment and calculation for 7 mol dm(-3) solutions of deaerated aqueous LiNO3 and HNO3, in the absence and presence of hydrazine (N2H4, N2H5(+), and N2H6(2+)). hydrazine 197-206 NBL1, DAN family BMP antagonist Homo sapiens 23-26 27171587-1 2016 The decay mechanism of NO3( ) has been determined through a combination of experiment and calculation for 7 mol dm(-3) solutions of deaerated aqueous LiNO3 and HNO3, in the absence and presence of hydrazine (N2H4, N2H5(+), and N2H6(2+)). hydrazine 208-212 NBL1, DAN family BMP antagonist Homo sapiens 23-26 27171587-6 2016 In highly acidic nitric acid solution, hydrazine exists mainly as N2H5(+) and N2H6(2+), both of which rapidly consume NO3( ) in addition to other decay mechanisms, with rate constants of 2.9 (+-0.9) x 10(7) and 1.3 (+-0.3) x 10(6) dm(3) mol(-1) s(-1), respectively. hydrazine 39-48 NBL1, DAN family BMP antagonist Homo sapiens 118-121 26869098-0 2016 Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen. hydrazine 143-152 Rh associated glycoprotein Homo sapiens 57-60 26700437-4 2016 We designed and prepared SNAIL1 peptides bearing a propargyl amine, hydrazine, or phenylcyclopropane moiety. hydrazine 68-77 snail family transcriptional repressor 1 Homo sapiens 25-31 26700437-5 2016 Among them, peptide 3, bearing hydrazine, displayed the most potent LSD1-inhibitory activity in enzyme assays. hydrazine 31-40 lysine demethylase 1A Homo sapiens 68-72 26153651-2 2015 This cascade process proceeds through initial condensation of the allenic ketone with hydrazine followed by Pd-catalyzed isocyanide insertion into the C-Br bond and intramolecular C-N bond formation. hydrazine 86-95 carbonyl reductase 1 Homo sapiens 151-155 26691211-1 2016 In order to investigate the defect effect on photocatalytic performance of the visible light photocatalyst, Zn-Cd-S solid solution with surface defects is prepared in the hydrazine hydrate. hydrazine 171-180 CDP-diacylglycerol synthase 1 Homo sapiens 111-115 26274784-0 2015 Naked-eye and near-infrared fluorescence probe for hydrazine and its applications in in vitro and in vivo bioimaging. hydrazine 51-60 naked Mus musculus 0-5 26146957-4 2015 Experiments that verify some of the predictions in this study are presented, and it is shown that GaS is effective in absorption of light and evolution of H2 (887 mumol h(-1) g(-1)) in the presence of aqueous solution of hydrazine (1% v/v). hydrazine 221-230 gastrin Homo sapiens 98-101 25869440-2 2015 After the addition of hydrazine, an approximately 50-fold enhancement in fluorescence intensity at 465 nm was observed and the subsequent decrease at 375 nm was observed in 10 min with a detection limit of 0.147 muM. hydrazine 22-31 latexin Homo sapiens 212-215 26079270-0 2015 Surface Modification of Li1.2Ni0.13Mn0.54Co0.13O2 by Hydrazine Vapor as Cathode Material for Lithium-Ion Batteries. hydrazine 53-62 transglutaminase 1 Homo sapiens 24-27 26079270-1 2015 An artificial interface is successfully prepared on the surface of the layered lithium-rich cathode material Li1.2Ni0.13Mn0.54Co0.12O2 via treating it with hydrazine vapor, followed by an annealing process. hydrazine 156-165 transglutaminase 1 Homo sapiens 109-112 26079270-2 2015 The inductively coupled plasma-atomic emission spectrometry (ICP) results indicate that lithium ions are leached out from the surface of Li1.2Ni0.13Mn0.54Co0.12O2 by the hydrazine vapor. hydrazine 170-179 transglutaminase 1 Homo sapiens 137-140 26057586-1 2015 A probe mediated SERS-based strategy is developed to selectively detect hydrazine with superb sensitivity. hydrazine 72-81 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 17-21 26057586-2 2015 Ortho-phthaldialdehyde, a simple probe, reacts specifically with hydrazine to form phthalazine, a molecule that possesses a larger Raman cross section and better affinity toward the SERS substrate. hydrazine 65-74 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 182-186 25744507-7 2015 Similarly, activity of alpha-amylase, lipase, trypsin and chymotrypsin was higher with HZn as compared with NZn and LZn diets (P<0.05), whereas elastase activity was unchanged. hydrazine 87-90 LOW QUALITY PROTEIN: pancreatic alpha-amylase Sus scrofa 23-36 25798622-6 2015 NAT2 acetylates arylamine and hydrazine drugs and carcinogens, but predicted acetylator NAT2 phenotypes were not associated with insulin sensitivity. hydrazine 30-39 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 0-4 25569325-7 2015 The electrocatalytic activity of the Au/PPy electrodes was assessed for the electro-oxidation of hydrazine and hydroxylamine. hydrazine 97-106 pancreatic polypeptide Homo sapiens 40-43 25565083-4 2015 These results led to a novel family of NCF3 and NCF2 hydrazine derivatives. hydrazine 53-62 neutrophil cytosolic factor 2 Homo sapiens 48-52 23242743-4 2013 Therefore, glucose uptake and incorporation into lipid were measured in mouse adipocytes in response to phenelzine, other hydrazine-based SSAO/PrAO-inhibitors, and reference agents. hydrazine 122-131 amine oxidase, copper containing 3 Mus musculus 138-142 25005845-1 2014 N-Acetyltransferase 2 (NAT2) is a polymorphic gene encoding the enzyme that metabolizes arylamine and hydrazine moieties. hydrazine 102-111 N-acetyltransferase 2 Homo sapiens 0-21 25005845-1 2014 N-Acetyltransferase 2 (NAT2) is a polymorphic gene encoding the enzyme that metabolizes arylamine and hydrazine moieties. hydrazine 102-111 N-acetyltransferase 2 Homo sapiens 23-27 25368434-2 2014 Transformation of an alkyl bromide to the corresponding alkoxyamine hydrochloride can be accomplished more rapidly in high yield and without using hazardous hydrazine by reaction of (Boc)2NOH (N,N"-di-tert-butoxycarbonylhydroxylamine) and alkyl bromide followed by addition of HCl. hydrazine 157-166 BOC cell adhesion associated, oncogene regulated Homo sapiens 183-186 24850322-1 2014 A series of BF2 complexes of hydrazine-Schiff base linked bispyrrole have been prepared from a simple two-step reaction from commercially available substances and are highly fluorescent in solution, film, and solid states with larger Stokes shift and excellent photostabilities comparable or even super to those of their BODIPY analogues. hydrazine 29-38 forkhead box G1 Homo sapiens 12-15 24532369-4 2014 Treatment of 6 with CS2 in the presence of potassium hydroxide (KOH), followed by cyclization with hydrazine hydrate, afforded 4-amino-5-{[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione (9). hydrazine 99-116 chorionic somatomammotropin hormone 2 Homo sapiens 20-23 23263540-2 2013 Hydrazine JL72 (3-(3-hydrazinylpropyl)-1H-indole) showed a potent, reversible and non-time-dependent inhibition of MAO-A, which suggests its capacity in restoring serotoninergic neurotransmission being devoid of the side effects observed for classic MAO-A inhibitors. hydrazine 0-9 monoamine oxidase A Homo sapiens 115-120 23263540-2 2013 Hydrazine JL72 (3-(3-hydrazinylpropyl)-1H-indole) showed a potent, reversible and non-time-dependent inhibition of MAO-A, which suggests its capacity in restoring serotoninergic neurotransmission being devoid of the side effects observed for classic MAO-A inhibitors. hydrazine 0-9 monoamine oxidase A Homo sapiens 250-255 24687332-0 2014 Novel hydrazine derivatives as selective DPP-IV inhibitors: findings from virtual screening and validation through molecular dynamics simulations. hydrazine 6-15 dipeptidyl peptidase 4 Homo sapiens 41-47 24687332-1 2014 The present study demonstrates and validates the discovery of two novel hydrazine derivatives as selective dipeptidyl peptidase-IV (DPP-IV) inhibitors. hydrazine 72-81 dipeptidyl peptidase 4 Homo sapiens 107-130 24687332-1 2014 The present study demonstrates and validates the discovery of two novel hydrazine derivatives as selective dipeptidyl peptidase-IV (DPP-IV) inhibitors. hydrazine 72-81 dipeptidyl peptidase 4 Homo sapiens 132-138 24687332-8 2014 Thus, the study reveals the potential of hydrazine derivatives as highly selective DPP-IV inhibitors. hydrazine 41-50 dipeptidyl peptidase 4 Homo sapiens 83-89 24262887-2 2013 Spectroscopic studies indicated that 2-hydrazinobenzothiazole interacted with the IDO1 haem and in silico docking predicted that the interaction was through hydrazine. hydrazine 157-166 indoleamine 2,3-dioxygenase 1 Homo sapiens 82-86 24262887-3 2013 Subsequent studies of hydrazine derivatives identified phenylhydrazine (IC50=0.25 +- 0.07 muM) to be 32-fold more potent than 2-hydrazinobenzothiazole (IC50=8.0 +- 2.3 muM) in inhibiting rhIDO1 and that it inhibited cellular IDO1 at concentrations that were noncytotoxic to cells. hydrazine 22-31 latexin Homo sapiens 90-93 23978111-2 2013 The as-synthesized Ag2O NWA/Cu rod not only can be used as an integrated electrode (called a Ag2O NWA/CRIE) to detect hydrazine (HZ) but also can serve as the catalyst layer for a direct HZ fuel cell. hydrazine 118-127 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 19-22 23624997-0 2013 Key role of hydrazine to the interaction between oxaloacetic against phosphoenolpyruvic carboxykinase (PEPCK): ONIOM calculations. hydrazine 12-21 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 69-101 23624997-0 2013 Key role of hydrazine to the interaction between oxaloacetic against phosphoenolpyruvic carboxykinase (PEPCK): ONIOM calculations. hydrazine 12-21 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 103-108 23624997-1 2013 The interactions between oxaloacetic (OAA) and phosphoenolpyruvic carboxykinase (PEPCK) binding pocket in the presence and absence of hydrazine were carried out using quantum chemical calculations, based on the two-layered ONIOM (ONIOM2) approach. hydrazine 134-143 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 47-79 23624997-1 2013 The interactions between oxaloacetic (OAA) and phosphoenolpyruvic carboxykinase (PEPCK) binding pocket in the presence and absence of hydrazine were carried out using quantum chemical calculations, based on the two-layered ONIOM (ONIOM2) approach. hydrazine 134-143 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 81-86 23479280-1 2013 A series of no-chlorine and oxygen-rich hydrazine derivatives (hydrazine modified with -NO2 and NO3(-) groups) was designed and optimized to obtain molecular geometries and electronic structures at density functional theory-B3PW91/6-311++G(3df,3pd) level. hydrazine 40-49 NBL1, DAN family BMP antagonist Homo sapiens 96-99 23487180-6 2013 As a possible application of the acetate probes, hydrazine signaling in tap water was tested. hydrazine 49-58 nuclear RNA export factor 1 Homo sapiens 72-75 22950847-3 2012 Treatment of [PhBP(mter)(3)]FeMe with hydrazine generates the unusual 5-coordinate hydrazido complex [PhBP(mter)(3)]Fe(eta(2)-N(2)H(3)) (1), in which the hydrazido serves as an L(2)X-type ligand. hydrazine 38-47 hyaluronan binding protein 2 Homo sapiens 14-18 23336362-3 2013 Starting from the biphenyl carrying hit as lead structure, the objective of the present study was to discover novel high affinity GAT1 binders by screening of biphenyl focused pseudostatic hydrazone libraries formed from hydrazine 10 and 36 biphenylcarbaldehydes 11c-al. hydrazine 221-230 solute carrier family 6 member 1 Homo sapiens 130-134 23215018-1 2013 Human epidermal growth factor receptor 2 (HER2) and HER2-overexpressing breast cancer cells were detected using an electrochemical immunosensor combined with hydrazine and aptamer-conjugated gold nanoparticles (AuNPs). hydrazine 158-167 erb-b2 receptor tyrosine kinase 2 Homo sapiens 0-40 23215018-1 2013 Human epidermal growth factor receptor 2 (HER2) and HER2-overexpressing breast cancer cells were detected using an electrochemical immunosensor combined with hydrazine and aptamer-conjugated gold nanoparticles (AuNPs). hydrazine 158-167 erb-b2 receptor tyrosine kinase 2 Homo sapiens 42-46 23065686-0 2013 Synthesis and selective human monoamine oxidase B inhibition of heterocyclic hybrids based on hydrazine and thiazole scaffolds. hydrazine 94-103 monoamine oxidase B Homo sapiens 30-49 23153812-4 2012 The substituent on the alpha-carbon to the N1-hydrazine moiety (methyl or hydrogen) had a great influence on the activity and hMAO-B selectivity. hydrazine 46-55 monoamine oxidase B Homo sapiens 126-132 23007636-3 2012 Reaction of [PdL2(NH3)2](PF6)2 with hydrazine led to a mixture of [Pd(L2)2](PF6)2 (9) and [PdL2(NH2N=C(CH3)NHNH2)](PF6)2 (10). hydrazine 36-45 programmed cell death 1 ligand 2 Homo sapiens 13-17 23007636-3 2012 Reaction of [PdL2(NH3)2](PF6)2 with hydrazine led to a mixture of [Pd(L2)2](PF6)2 (9) and [PdL2(NH2N=C(CH3)NHNH2)](PF6)2 (10). hydrazine 36-45 programmed cell death 1 ligand 2 Homo sapiens 91-95 22950847-3 2012 Treatment of [PhBP(mter)(3)]FeMe with hydrazine generates the unusual 5-coordinate hydrazido complex [PhBP(mter)(3)]Fe(eta(2)-N(2)H(3)) (1), in which the hydrazido serves as an L(2)X-type ligand. hydrazine 38-47 hyaluronan binding protein 2 Homo sapiens 102-106 22950847-5 2012 In contrast, treatment of [PhBP(Ph)(3)]FeMe with hydrazine forms the adduct [PhBP(Ph)(3)]Fe(Me)(eta(2)-N(2)H(4)) (5). hydrazine 49-58 hyaluronan binding protein 2 Homo sapiens 27-31 22950847-5 2012 In contrast, treatment of [PhBP(Ph)(3)]FeMe with hydrazine forms the adduct [PhBP(Ph)(3)]Fe(Me)(eta(2)-N(2)H(4)) (5). hydrazine 49-58 hyaluronan binding protein 2 Homo sapiens 77-81 21962661-3 2011 A high-sensitivity of ~ 89.3 muA cm(-2) muM and low limit of detection of 1.07 muM, based on S/N ratio, were obtained for the fabrication of hydrazine chemical sensor based on P-ZnS NPs. hydrazine 141-150 latexin Homo sapiens 40-43 22689508-6 2012 For the screening, hydrazone libraries were employed that were generated in the presence of the target by reacting various sets of aldehydes with a hydrazine derivative that is delineated from piperidine-3-carboxylic acid (nipecotic acid), a common fragment of known GAT1 inhibitors. hydrazine 148-157 solute carrier family 6 member 1 Homo sapiens 267-271 22137746-5 2012 Acryloyl hydrazine (AH) has been shown to behave as a bidentate ligand via its nitrogen (NH(2) of hydrazine group) and C-O/C=O (acryloyl group) in polymer complexes, all of which exhibit supramolecular architectures assembled through weak interaction including hydrogen bonding and pi-pi stacking .The magnetic and spectral data indicate a square planar geometry for Cu(2+) complexes and an octahedral geometry for Co(II) and UO(2)(II). hydrazine 9-18 mitochondrially encoded cytochrome c oxidase II Homo sapiens 415-421 22123120-4 2012 The sensitivity enhancement with nearly two orders of magnitude was gained, compared with the bare carbon paste electrode, with the detection limit of 0.91 muM (S/N=3) for hydrazine. hydrazine 172-181 latexin Homo sapiens 156-159 21962661-3 2011 A high-sensitivity of ~ 89.3 muA cm(-2) muM and low limit of detection of 1.07 muM, based on S/N ratio, were obtained for the fabrication of hydrazine chemical sensor based on P-ZnS NPs. hydrazine 141-150 latexin Homo sapiens 79-82 21567549-4 2010 In accord with the aminolysis results on CTAs, hydrazine aminolyzed RAFT polymers in an impressively short time and, more importantly, it significantly suppressed the formation of disulfides as comfirmed with GPC. hydrazine 47-56 glycophorin C (Gerbich blood group) Homo sapiens 209-212 21645672-3 2011 The PB-graphene/GCE showed sensitive response to H(2)O(2) with a wide linear range of 10-1440 muM at 0.0V, and to hydrazine with a wide linear range of 10-3000 muM at 0.35 V. The detection limit was 3 muM and 7 muM, respectively, and both of them had rapid response within 5s to reach 95% steady state response. hydrazine 114-123 aminomethyltransferase Homo sapiens 16-19 21645672-3 2011 The PB-graphene/GCE showed sensitive response to H(2)O(2) with a wide linear range of 10-1440 muM at 0.0V, and to hydrazine with a wide linear range of 10-3000 muM at 0.35 V. The detection limit was 3 muM and 7 muM, respectively, and both of them had rapid response within 5s to reach 95% steady state response. hydrazine 114-123 latexin Homo sapiens 160-163 21645672-3 2011 The PB-graphene/GCE showed sensitive response to H(2)O(2) with a wide linear range of 10-1440 muM at 0.0V, and to hydrazine with a wide linear range of 10-3000 muM at 0.35 V. The detection limit was 3 muM and 7 muM, respectively, and both of them had rapid response within 5s to reach 95% steady state response. hydrazine 114-123 latexin Homo sapiens 160-163 21645672-3 2011 The PB-graphene/GCE showed sensitive response to H(2)O(2) with a wide linear range of 10-1440 muM at 0.0V, and to hydrazine with a wide linear range of 10-3000 muM at 0.35 V. The detection limit was 3 muM and 7 muM, respectively, and both of them had rapid response within 5s to reach 95% steady state response. hydrazine 114-123 latexin Homo sapiens 160-163 21645672-4 2011 The wide linear range, good selectivity and long-time stability of the PB-graphene/GCE make it possible for the practical amperometric detection of hydrogen peroxide and hydrazine. hydrazine 170-179 aminomethyltransferase Homo sapiens 83-86 21405023-0 2011 Novel hydrazine molecules as tools to understand the flexibility of vascular adhesion protein-1 ligand-binding site: toward more selective inhibitors. hydrazine 6-15 amine oxidase copper containing 3 Homo sapiens 68-95 21405023-5 2011 In this study, eight novel VAP-1 hydrazine derivatives were synthesized and their VAP-1 and monoamine oxidase (MAO) inhibition ability was determined in vitro. hydrazine 33-42 amine oxidase copper containing 3 Homo sapiens 27-32 21405023-5 2011 In this study, eight novel VAP-1 hydrazine derivatives were synthesized and their VAP-1 and monoamine oxidase (MAO) inhibition ability was determined in vitro. hydrazine 33-42 amine oxidase copper containing 3 Homo sapiens 82-87 21405023-7 2011 The increase in the size of the VAP-1 ligands, together with the methylation of the secondary nitrogen atom of the hydrazine moiety, improves the VAP-1 selectivity over MAO. hydrazine 115-124 amine oxidase copper containing 3 Homo sapiens 32-37 21405023-7 2011 The increase in the size of the VAP-1 ligands, together with the methylation of the secondary nitrogen atom of the hydrazine moiety, improves the VAP-1 selectivity over MAO. hydrazine 115-124 amine oxidase copper containing 3 Homo sapiens 146-151 21347396-1 2011 Arylamine N-acetyltransferase-1 (NAT1) is an enzyme that catalyzes the biotransformation of arylamine and hydrazine substrates. hydrazine 106-115 N-acetyltransferase 1 Homo sapiens 0-31 21347396-1 2011 Arylamine N-acetyltransferase-1 (NAT1) is an enzyme that catalyzes the biotransformation of arylamine and hydrazine substrates. hydrazine 106-115 N-acetyltransferase 1 Homo sapiens 33-37 21982573-2 2011 The intermediates ethyl [(18)F]-fluorinated benzene and pyridine esters were reacted with hydrazine to produce the [(18)F]-fluorobenzene and pyridinecarbohydrazides, followed by coupling with N-hydroxysuccinimide-folate/MTX. hydrazine 90-99 metaxin 1 Mus musculus 220-223 21645672-2 2011 The as-prepared PB-graphene modified glassy carbon electrode (PB-graphene/GCE) showed excellent electrocatalytic activity towards both the reduction of hydrogen peroxide and the oxidation of hydrazine, which could be attributed to the remarkable synergistic effect of graphene and PB. hydrazine 191-200 aminomethyltransferase Homo sapiens 74-77 21384002-1 2011 The reactivity of hydrazine in the presence of diborane has been investigated using ab initio quantum chemical computations (MP2 and CCSD(T) methods with the aug-cc-pVTZ basis set). hydrazine 18-27 tryptase pseudogene 1 Homo sapiens 125-128 21148252-0 2011 CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism. hydrazine 42-51 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-5 21980537-1 2011 BACKGROUND: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. hydrazine 130-139 N-acetyltransferase 2 Homo sapiens 12-43 21980537-1 2011 BACKGROUND: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals. hydrazine 130-139 N-acetyltransferase 2 Homo sapiens 45-49 20945907-3 2010 Further enhancement of the antimitotic activity of the ceratamine pharmacophore has been achieved in the synthetic analogue 33, which has both bromine atoms replaced with methyl groups and an additional methyl substituent on the amino nitrogen at C-2. hydrazine 229-243 complement C2 Homo sapiens 247-250 20812745-5 2010 We report that when a single amino acid within the MoFe protein (beta-98(Tyr)) is substituted by His, the resulting MoFe protein supports catalytic reduction of the nitrogenous substrate hydrazine (N(2)H(4)) to two ammonia molecules when provided with a low potential reductant, polyaminocarboxylate ligated Eu(II) (E(m) -1.1 V vs NHE). hydrazine 187-196 solute carrier family 9 member C1 Homo sapiens 331-334 20690686-0 2010 Synthesis, in vitro activity, and three-dimensional quantitative structure-activity relationship of novel hydrazine inhibitors of human vascular adhesion protein-1. hydrazine 106-115 amine oxidase copper containing 3 Homo sapiens 136-163 19237440-0 2009 Evaluation of conditions for release of mucin-type oligosaccharides from glycoproteins by hydrazine gas treatment. hydrazine 90-99 mucin 1, cell surface associated Bos taurus 40-45 19847037-1 2009 Nafion was used for the first time to aid in preparing stable graphene dispersions in mixed water/ethanol (1:1) solvents via the reduction of graphite oxide using hydrazine. hydrazine 163-172 activation induced cytidine deaminase Homo sapiens 38-41 19780601-0 2009 Comprehensive DFT and MP2 level investigations of reaction of 2,3-dihydro-1,5-benzodiazepine-2-thiones with hydrazine. hydrazine 108-117 tryptase pseudogene 1 Homo sapiens 22-25 19450867-3 2009 At pH1, the amount of the hydrazine adsorption on coal ash was very small and hydrazine was mainly decomposed by ultrasonic irradiation. hydrazine 26-35 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 3-6 19450867-3 2009 At pH1, the amount of the hydrazine adsorption on coal ash was very small and hydrazine was mainly decomposed by ultrasonic irradiation. hydrazine 78-87 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 3-6 19450867-4 2009 At pH4, hydrazine was mainly adsorbed on coal ash and not decomposed by ultrasonic irradiation. hydrazine 8-17 prolyl 4-hydroxylase, transmembrane Homo sapiens 3-6 19717294-3 2009 To obtain the final sensor probe, an antibody (anti-Annexin II) and hydrazine (Hyd), which is a catalyst for the reduction of H(2)O(2) generated by glucose oxidase (GOx), were covalently attached onto the Den/AuNP-modified surface. hydrazine 68-77 hydroxyacid oxidase 1 Homo sapiens 148-163 19717294-3 2009 To obtain the final sensor probe, an antibody (anti-Annexin II) and hydrazine (Hyd), which is a catalyst for the reduction of H(2)O(2) generated by glucose oxidase (GOx), were covalently attached onto the Den/AuNP-modified surface. hydrazine 68-77 hydroxyacid oxidase 1 Homo sapiens 165-168 19809664-1 2009 Potential energy surfaces for H(2) release from hydrazine interacting with borane, alane, diborane, dialane and borane-alane were constructed from MP2/aVTZ geometries and zero point energies with single point energies at the CCSD(T)/aug-cc-pVTZ level. hydrazine 48-57 tryptase pseudogene 1 Homo sapiens 147-150 19237440-1 2009 By using commercially available anhydrous hydrazine in the gas-phase, mucin-type oligosaccharides were released from porcine gastric mucin (PGM) and bovine fetuin. hydrazine 42-51 mucin 1, cell surface associated Bos taurus 70-75 19237440-1 2009 By using commercially available anhydrous hydrazine in the gas-phase, mucin-type oligosaccharides were released from porcine gastric mucin (PGM) and bovine fetuin. hydrazine 42-51 mucin 1, cell surface associated Bos taurus 133-138 18801426-5 2008 Hydrazine derivatives prevented the formation of foam cells resulting from LDL oxidation in human macrophagic U937 cells, and blocked the carbonyl stress in SMCs, by inhibiting the decrease in free amino group content, the increase in carbonylated proteins, and the formation of 4-HNE adducts on PDGFR. hydrazine 0-9 platelet derived growth factor receptor beta Homo sapiens 296-301 19199678-1 2009 Structural and spectroscopic properties of hydrazine, H(2)N-NH(2), it being a floppy or fluxional molecule in a vacuum, are investigated by means of ab initio molecular dynamics, ab initio path integral molecular dynamics, and ab initio ring polymer molecular dynamics simulations in conjunction with "on-the-fly" MP2 and CIS(D) electronic structure calculations. hydrazine 43-52 Serine protease 7 Drosophila melanogaster 314-317 18950231-1 2008 The preparation and application of new solid supports with chiral linkers, analogues of SAMP hydrazine on solid-phase, are described. hydrazine 93-102 X-prolyl aminopeptidase 1 Homo sapiens 88-92 18680467-1 2008 Arylamine N-acetyltransferase 2 (NAT2) modifies drug efficacy/toxicity and cancer risk due to its role in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. hydrazine 156-165 N-acetyltransferase 2 Homo sapiens 0-31 18680467-1 2008 Arylamine N-acetyltransferase 2 (NAT2) modifies drug efficacy/toxicity and cancer risk due to its role in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. hydrazine 156-165 N-acetyltransferase 2 Homo sapiens 33-37 18680467-9 2008 This analysis advances understanding of NAT2 structure-function relationships, important for interpreting the role of NAT2 genetic polymorphisms in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. hydrazine 198-207 N-acetyltransferase 2 Homo sapiens 40-44 18680467-9 2008 This analysis advances understanding of NAT2 structure-function relationships, important for interpreting the role of NAT2 genetic polymorphisms in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. hydrazine 198-207 N-acetyltransferase 2 Homo sapiens 118-122 18457951-6 2008 This indirect oxidation of the hydrazine group in this anticancer agent indicates possible application of a hydrazine linker in construction of tyrosinase-activated anti-melanoma prodrugs. hydrazine 31-40 tyrosinase Homo sapiens 144-154 18457951-6 2008 This indirect oxidation of the hydrazine group in this anticancer agent indicates possible application of a hydrazine linker in construction of tyrosinase-activated anti-melanoma prodrugs. hydrazine 108-117 tyrosinase Homo sapiens 144-154 18544910-3 2008 Acetylating pathway of INH to acetyl isoniazid (AcINH) tended to shift to the hydrolytic pathway generating hydrazine (Hz) with the increase of mutant alleles in NAT2 gene. hydrazine 108-117 N-acetyltransferase 2 Homo sapiens 162-166 18373979-1 2008 Genetic variation in human N-acetyltransferases (NAT) has been implicated in susceptibility to aromatic amine and hydrazine carcinogens and therapeutic drugs. hydrazine 114-123 bromodomain containing 2 Homo sapiens 27-47 18373979-1 2008 Genetic variation in human N-acetyltransferases (NAT) has been implicated in susceptibility to aromatic amine and hydrazine carcinogens and therapeutic drugs. hydrazine 114-123 bromodomain containing 2 Homo sapiens 49-52 17656365-1 2007 The human arylamine N-acetyltransferases NAT1 and NAT2 play an important role in the biotransformation of a plethora of aromatic amine and hydrazine drugs. hydrazine 139-148 N-acetyltransferase 1 Homo sapiens 41-45 18288399-1 2008 Arylamine N-acetyltransferase type 1 (NAT1) is reported to be involved in the transfer of an acetyl group from acetyl-CoA to the terminal nitrogen of hydrazine and arylamine drugs or carcinogens. hydrazine 150-159 N-acetyltransferase 1 Homo sapiens 38-42 17983220-2 2007 The structure exhibits the first eta2 coordination of hydrazine to iron, which may be relevant to intermediates trapped during nitrogenase turnover. hydrazine 54-63 DNA polymerase iota Homo sapiens 33-37 17656365-1 2007 The human arylamine N-acetyltransferases NAT1 and NAT2 play an important role in the biotransformation of a plethora of aromatic amine and hydrazine drugs. hydrazine 139-148 N-acetyltransferase 2 Homo sapiens 50-54 17360465-2 2007 To overcome this barrier, we have synthesized a versatile TLR7 agonist, 4-[6-amino-8-hydroxy-2-(2-methoxyethoxy)purin-9-ylmethyl]benzaldehyde (UC-1V150), bearing a free aldehyde that could be coupled to many different auxiliary chemical entities through a linker molecule with a hydrazine or amino group without any loss of activity. hydrazine 279-288 toll-like receptor 7 Mus musculus 58-62 17625836-1 2007 Addition of 2,2"-bipyridine and its derivatives to Ti(NMe2)2(dpma), where dpma is N,N-di(pyrrolyl-alpha-methyl)-N-methylamine, followed by various hydrazine derivatives was used to generate a series of terminal hydrazido(2-) complexes. hydrazine 147-156 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 54-58 16857729-1 2006 Arylamine N-acetyltransferases (Nat) 1 and 2 catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens. hydrazine 94-103 N-acetyl transferase 1 Mus musculus 10-44 17392017-0 2007 Arylamine N-acetyltransferase I. Arylamine N-acetyltransferase I (NAT1) is a phase II enzyme that acetylates a wide range of arylamine and hydrazine substrates. hydrazine 139-148 N-acetyltransferase 1 Homo sapiens 66-70 16302799-5 2005 Indeed, the addition of hydrazine on the THR-inhibitor complex promotes a partial induced THR reactivation. hydrazine 24-33 coagulation factor II, thrombin Homo sapiens 41-44 16359183-12 2005 We propose that the metabolism-based inactivation of nNOS by AG, DAG, and NAA occurs through oxidative removal of the hydrazine group and the formation of a radical intermediate that forms stable products after H-atom abstraction or reacts with the heme prosthetic moiety and inactivates nNOS. hydrazine 118-127 nitric oxide synthase 1 Homo sapiens 53-57 16942283-0 2006 Direct dynamics study on the hydrogen abstraction reactions N2H4 + R-->N2H3 + RH (R=NH2, CH3). hydrazine 60-64 NLR family pyrin domain containing 4 Homo sapiens 85-90 16365099-5 2006 Because nonessential amino nitrogen is an important component of nutritional nitrogen and can be limiting for growth under certain circumstances, and because BCAA are an important source of nonessential amino nitrogen, we have examined the relations among the transamination of leucine, leucine N kinetics, and urea synthesis and glutamine kinetics in human pregnancy and newborn infants. hydrazine 203-217 AT-rich interaction domain 4B Homo sapiens 158-162 16302799-5 2005 Indeed, the addition of hydrazine on the THR-inhibitor complex promotes a partial induced THR reactivation. hydrazine 24-33 coagulation factor II, thrombin Homo sapiens 90-93 16226721-9 2005 SBAT1-mediated transport of BCAA, particularly leucine, may be an important source of amino nitrogen for neurotransmitter synthesis in glutamatergic and GABAergic neurons. hydrazine 86-100 solute carrier family 6 member 15 Homo sapiens 0-5 16023952-11 2005 The long-term stability of the GOx/hydrazine sensor was better than that of the one based on a GOx/HRP biosensor. hydrazine 35-44 hydroxyacid oxidase 1 Homo sapiens 31-34 16116337-4 2005 Parallel experiments were run with semicarbazide, the prototypical hydrazine SSAO inhibitor. hydrazine 67-76 amine oxidase, copper containing 3 Rattus norvegicus 77-81 16025186-5 2005 The hydrazine [PtCl(NH2NH2){PPh(OEt)2}2]BPh4 complex was also prepared by allowing PtHClP2 to react first with AgCF3SO3 and then with hydrazine. hydrazine 4-13 enolase 1 Homo sapiens 28-31 16025186-5 2005 The hydrazine [PtCl(NH2NH2){PPh(OEt)2}2]BPh4 complex was also prepared by allowing PtHClP2 to react first with AgCF3SO3 and then with hydrazine. hydrazine 134-143 enolase 1 Homo sapiens 28-31 15579122-1 2004 This paper describes a convenient synthesis of protected hydrazine derivatives, i.e. 1,2-bis-Boc-hydrazinoacetic acid, and its application for hydrazone ligation techniques in convergent template assembled synthetic protein (TASP) synthesis. hydrazine 57-66 LanC like 2 Homo sapiens 187-223 15909042-3 2005 The solution NMR spectroscopic and X-ray crystallographic studies are indicative of a trigonal bipyramidal geometry for these aluminium complexes in which the amino nitrogen atom is trans to the phosphorus donor of the [PNN]- ligand. hydrazine 159-173 pinin, desmosome associated protein Homo sapiens 220-223 15913380-6 2005 Treatment of [(eta5-C5Me4H)2Zr]2(mu2,eta2,eta2-N2) with HNMe2 or H2NNMe2 furnished amido or hydrazido zirconocene diazenido complexes that ultimately produce hydrazine upon protonation with ethanol. hydrazine 158-167 DNA polymerase iota Homo sapiens 42-46 16119198-1 2005 A series of hydrazine derivatives was synthesized in order to evaluate their monoamine oxidase A (MAO-A) inhibitory effects. hydrazine 12-21 monoamine oxidase A Rattus norvegicus 77-96 16119198-1 2005 A series of hydrazine derivatives was synthesized in order to evaluate their monoamine oxidase A (MAO-A) inhibitory effects. hydrazine 12-21 monoamine oxidase A Rattus norvegicus 98-103 15796204-1 2005 Many arylamine and hydrazine drugs are acetylated by cytosolic N-acetyltransferase (NAT). hydrazine 19-28 bromodomain containing 2 Homo sapiens 63-82 15796204-1 2005 Many arylamine and hydrazine drugs are acetylated by cytosolic N-acetyltransferase (NAT). hydrazine 19-28 bromodomain containing 2 Homo sapiens 84-87 15859284-3 2005 Reduction of 2 and 4 by addition of excess hydrazine gave one-electron-reduced neutral products Ru3O(OAc)5(py)2{micro-eta1 (C),eta2(N,N)-bipyridine} (bipyridine = dbbpy (2a), bpy (4a)). hydrazine 43-52 secreted phosphoprotein 1 Homo sapiens 118-122 15859284-3 2005 Reduction of 2 and 4 by addition of excess hydrazine gave one-electron-reduced neutral products Ru3O(OAc)5(py)2{micro-eta1 (C),eta2(N,N)-bipyridine} (bipyridine = dbbpy (2a), bpy (4a)). hydrazine 43-52 DNA polymerase iota Homo sapiens 127-131 15913380-0 2005 Dinitrogen functionalization with terminal alkynes, amines, and hydrazines promoted by [(eta5-C5Me4H)2Zr]2(mu2,eta2,eta2-N2): observation of side-on and end-on diazenido complexes in the reduction of N2 to hydrazine. hydrazine 64-73 DNA polymerase iota Homo sapiens 111-115 15913380-0 2005 Dinitrogen functionalization with terminal alkynes, amines, and hydrazines promoted by [(eta5-C5Me4H)2Zr]2(mu2,eta2,eta2-N2): observation of side-on and end-on diazenido complexes in the reduction of N2 to hydrazine. hydrazine 64-73 DNA polymerase iota Homo sapiens 116-120 15579122-1 2004 This paper describes a convenient synthesis of protected hydrazine derivatives, i.e. 1,2-bis-Boc-hydrazinoacetic acid, and its application for hydrazone ligation techniques in convergent template assembled synthetic protein (TASP) synthesis. hydrazine 57-66 LanC like 2 Homo sapiens 225-229 15219989-0 2004 Hydroxylamine and hydrazine bind directly to the heme iron of the heme-heme oxygenase-1 complex. hydrazine 18-27 heme oxygenase 1 Homo sapiens 71-87 15132840-7 2004 Correlation analysis showed that sALT had a positive correlation with plasma hydrazine and with CYP2E1 activity; CYP2E1 activity was also markedly correlated with plasma hydrazine. hydrazine 170-179 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 113-119 15132840-8 2004 And compared with control, there is no difference in changes of CYP2E1 mRNA expression in INH and INH-RFP treatment for 21 d. CONCLUSION: The metabolite of INH, hydrazine, plays an important role in INH-induced hepatotoxicity in rats. hydrazine 161-170 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 64-70 15132840-9 2004 The induction of CYP2E1 by hydrazine is involved in the hepatotoxicity of INH. hydrazine 27-36 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 17-23 12946272-1 2003 Human N -acetyltransferase Type I (NAT1) catalyses the acetylation of many aromatic amine and hydrazine compounds and it has been implicated in the catabolism of folic acid. hydrazine 94-103 N-acetyltransferase 1 Homo sapiens 35-39 15274340-1 2004 Many arylamines (including carcinogens) and hydrazine drugs are acetylated by the cytosolic N-acetyltransferase (NAT). hydrazine 44-53 bromodomain containing 2 Homo sapiens 113-116 15162844-2 2004 The N-acetyltransferase 2 (NAT2) acetylation polymorphism have been associated with a number of drug-induced toxicities and cancer in various tissues, resulting from decreased capacity to activate/deactivate several aromatic amine, hydrazine drugs, as well as HA carcinogens. hydrazine 232-241 N-acetyltransferase 2 Homo sapiens 4-25 15162844-2 2004 The N-acetyltransferase 2 (NAT2) acetylation polymorphism have been associated with a number of drug-induced toxicities and cancer in various tissues, resulting from decreased capacity to activate/deactivate several aromatic amine, hydrazine drugs, as well as HA carcinogens. hydrazine 232-241 N-acetyltransferase 2 Homo sapiens 27-31 12832400-3 2003 Human arylamine N-acetyltransferase 1 (NAT1) is a polymorphic ubiquitous phase II xenobiotic metabolizing enzyme that catalyzes the biotransformation of primary aromatic amine or hydrazine drugs and carcinogens. hydrazine 179-188 N-acetyltransferase 1 Homo sapiens 6-37 12832400-3 2003 Human arylamine N-acetyltransferase 1 (NAT1) is a polymorphic ubiquitous phase II xenobiotic metabolizing enzyme that catalyzes the biotransformation of primary aromatic amine or hydrazine drugs and carcinogens. hydrazine 179-188 N-acetyltransferase 1 Homo sapiens 39-43 19475278-6 2003 Cytochrome P450 isoenzymes show genetic polymorphisms in neuropsychotropic drugs metabolism and the slow acetylation of N-acetyltransferase in equatorial populations (95%) increases isoniazid and hydrazine toxicity. hydrazine 196-205 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 12878219-1 2003 Human arylamine N-acetyltransferase 1 (NAT1) is a polymorphic phase II xenobiotic-metabolizing enzyme which catalyzes the biotransformation of primary aromatic amines, hydrazine drugs, and carcinogens. hydrazine 168-177 N-acetyltransferase 1 Homo sapiens 6-37 12878219-1 2003 Human arylamine N-acetyltransferase 1 (NAT1) is a polymorphic phase II xenobiotic-metabolizing enzyme which catalyzes the biotransformation of primary aromatic amines, hydrazine drugs, and carcinogens. hydrazine 168-177 N-acetyltransferase 1 Homo sapiens 39-43 11725342-7 2001 N-acetyltransferase 2 (NAT2), metabolizing xenobiotics with primary aromatic amine and hydrazine structures, is another important polymorphic phase II enzyme. hydrazine 87-96 N-acetyltransferase 2 Homo sapiens 0-21 12715953-3 2003 Acetylation polymorphism relates to the metabolism of a number of arylamine and hydrazine drugs and carcinogens by cytosolic N-acetyltransferase--NAT2. hydrazine 80-89 N-acetyltransferase 2 Homo sapiens 146-150 12564389-10 2003 The use of hydrazine sulfate to impede gluconeogenesis through PEP carboxykinase (PEPCK) inhibition heightened the protective effects of energy substrates possibly due to attenuated ATP demands from pyruvate carboxylase (PC) activity and pyruvate mitochondrial transport. hydrazine 11-28 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 63-80 12564389-10 2003 The use of hydrazine sulfate to impede gluconeogenesis through PEP carboxykinase (PEPCK) inhibition heightened the protective effects of energy substrates possibly due to attenuated ATP demands from pyruvate carboxylase (PC) activity and pyruvate mitochondrial transport. hydrazine 11-28 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 82-87 12564389-10 2003 The use of hydrazine sulfate to impede gluconeogenesis through PEP carboxykinase (PEPCK) inhibition heightened the protective effects of energy substrates possibly due to attenuated ATP demands from pyruvate carboxylase (PC) activity and pyruvate mitochondrial transport. hydrazine 11-28 pyruvate carboxylase Mus musculus 199-219 12495343-4 2002 The molecule possesses pyramidal configuration at the amino nitrogen atom, and the following geometric parameters (r(a) values with 3sigma uncertainties) were obtained for the NONO(2) skeleton: N-O = 1.392(18) A, O-N = 1.597(16) A, (N=O)(mean) = 1.192(4) A, N-O-N = 106.9(25) degrees, O=N=O = 138.4(24) degrees. hydrazine 54-68 non-POU domain containing octamer binding Homo sapiens 176-180 12353701-2 2002 Hardware and software improvements have been made to a two-color infrared tunable diode laser (IR-TDL) spectrometer in order to improve the limit of detection (LOD) of hydrazine (N2H4) in the cigarette smoke matrix. hydrazine 168-177 apelin receptor early endogenous ligand Homo sapiens 98-101 12353701-2 2002 Hardware and software improvements have been made to a two-color infrared tunable diode laser (IR-TDL) spectrometer in order to improve the limit of detection (LOD) of hydrazine (N2H4) in the cigarette smoke matrix. hydrazine 179-183 apelin receptor early endogenous ligand Homo sapiens 98-101 12353701-9 2002 This is a factor of 10 less than the 4.2 ppmv detection limit for hydrazine in the smoke matrix, and indicates that the detection limit is primarily a result of the complexity of the matrix rather than the random noise of the TDL instrument. hydrazine 66-75 apelin receptor early endogenous ligand Homo sapiens 226-229 11725342-7 2001 N-acetyltransferase 2 (NAT2), metabolizing xenobiotics with primary aromatic amine and hydrazine structures, is another important polymorphic phase II enzyme. hydrazine 87-96 N-acetyltransferase 2 Homo sapiens 23-27 11108798-1 2000 Human N-acetyltransferase 1 (NAT1) is a widely distributed enzyme that catalyses the acetylation of arylamine and hydrazine drugs as well as several known carcinogens, and so its levels in the body may have toxicological importance with regard to drug toxicity and cancer risk. hydrazine 114-123 N-acetyltransferase 1 Homo sapiens 6-27 11562071-5 2001 (4) When the PSK fraction subjected to hydrolysis with beta1-3 glucanase or hydrazine was used instead of PSK, the anti-fungal activities were significantly decreased. hydrazine 76-85 TAO kinase 2 Mus musculus 13-16 11330906-1 2001 Treatment of 1,1,4,4-tetramethyl-2,3-diazabutadiene with the alane adduct [AlH3(NMe2Et)] yielded the hydrazine derivative (AlH2)2-(AlH)2(N2iPr2)3 (1) by the hydroalumination of both C N double bonds. hydrazine 101-110 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 80-84 11108798-1 2000 Human N-acetyltransferase 1 (NAT1) is a widely distributed enzyme that catalyses the acetylation of arylamine and hydrazine drugs as well as several known carcinogens, and so its levels in the body may have toxicological importance with regard to drug toxicity and cancer risk. hydrazine 114-123 N-acetyltransferase 1 Homo sapiens 29-33 11087716-3 2000 Hydrazine/nitrous acid/NaBH(4) treatment of the HA from the subcellular fractions indicated that C-3 of the galactose as well as C-6 of the N-acetylglucosamine residues of the N-acetyllactosamine chains became sulfated in these post ER fractions, as did the C-6 of the outer N-acetylglucosamine of the di-N-acetylchitobiose core. hydrazine 0-9 complement C3 Canis lupus familiaris 97-100 11087716-3 2000 Hydrazine/nitrous acid/NaBH(4) treatment of the HA from the subcellular fractions indicated that C-3 of the galactose as well as C-6 of the N-acetylglucosamine residues of the N-acetyllactosamine chains became sulfated in these post ER fractions, as did the C-6 of the outer N-acetylglucosamine of the di-N-acetylchitobiose core. hydrazine 0-9 complement C6 Canis lupus familiaris 129-132 11087716-3 2000 Hydrazine/nitrous acid/NaBH(4) treatment of the HA from the subcellular fractions indicated that C-3 of the galactose as well as C-6 of the N-acetylglucosamine residues of the N-acetyllactosamine chains became sulfated in these post ER fractions, as did the C-6 of the outer N-acetylglucosamine of the di-N-acetylchitobiose core. hydrazine 0-9 complement C6 Canis lupus familiaris 258-261