PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16205320-3	2005	We developed a chronic porcine model of septic shock and ARDS and hypothesized that blocking the proteases neutrophil elastase (NE) and matrix metalloproteinases (MMP-2 and MMP-9) with the modified tetracycline, COL-3, would significantly improve morbidity in this model.	tet	198-210	matrix metallopeptidase 2	Sus scrofa	163-168
16205320-3	2005	We developed a chronic porcine model of septic shock and ARDS and hypothesized that blocking the proteases neutrophil elastase (NE) and matrix metalloproteinases (MMP-2 and MMP-9) with the modified tetracycline, COL-3, would significantly improve morbidity in this model.	tet	198-210	matrix metallopeptidase 9	Sus scrofa	173-178
16083855-0	2005	Microarray analysis of the genes induced by tetracycline-regulated expression of NDRF/NeuroD2 in P19 cells.	tet	44-56	neurogenic differentiation 2	Mus musculus	81-85
16083855-0	2005	Microarray analysis of the genes induced by tetracycline-regulated expression of NDRF/NeuroD2 in P19 cells.	tet	44-56	neurogenic differentiation 2	Mus musculus	86-93
16083855-2	2005	To elucidate the NDRF transcription network, we used mouse cDNA microarray analysis combined with a tetracycline-regulatable expression system in P19 embryonal carcinoma cells.	tet	100-112	neurogenic differentiation 2	Mus musculus	17-21
15981277-4	2005	The level of transferrin produced was found to increase proportionately with tetracycline concentration between 0 and 1 mug/mL with no significant increases in transferrin production above 1 mug/mL.	tet	77-89	transferrin	Homo sapiens	13-24
16033759-3	2005	Employing both stably transfected lines of human MCF7 cells containing tetracycline-regulated HMGA1 transgenes and primary Hs578T tumor cells, which naturally overexpress HMGA1 proteins, we have shown that cells overexpressing HMGA1a protein exhibit increased UV sensitivity.	tet	71-83	high mobility group AT-hook 1	Homo sapiens	94-99
16033759-3	2005	Employing both stably transfected lines of human MCF7 cells containing tetracycline-regulated HMGA1 transgenes and primary Hs578T tumor cells, which naturally overexpress HMGA1 proteins, we have shown that cells overexpressing HMGA1a protein exhibit increased UV sensitivity.	tet	71-83	high mobility group AT-hook 1	Homo sapiens	227-233
16131058-8	2005	We confirmed that TC has an inhibitory effect on the production of GFP and CAT in the E. coli expression system whereas CH has a negligible effect.	tet	18-20	chloramphenicol acetyltransferase	Escherichia coli	75-78
16248154-4	2005	Like amyloid fibrils of Abeta-peptide and tau protein in Alzheimer"s disease, amyloid aggregates formed by X-, C-, and H-proteins are destroyed by the antibiotic tetracycline.	tet	162-174	microtubule associated protein tau	Homo sapiens	42-45
16102586-2	2005	To understand the carcinogenic role of THY-1, and its downstream effects on cancer cells, a THY-1 inducible system was established in the human ovarian cancer cell line SKOV-3 based on the tetracycline (tet) regulating system.	tet	189-201	Thy-1 cell surface antigen	Homo sapiens	92-97
16102586-2	2005	To understand the carcinogenic role of THY-1, and its downstream effects on cancer cells, a THY-1 inducible system was established in the human ovarian cancer cell line SKOV-3 based on the tetracycline (tet) regulating system.	tet	189-192	Thy-1 cell surface antigen	Homo sapiens	92-97
15965644-4	2005	In the current work, we have used HeLa cells carrying wild-type or Q283P-mutant HFE cDNA under the control of a tetracycline-sensitive promoter to functionally characterise the Q283P mutation.	tet	112-124	homeostatic iron regulator	Homo sapiens	80-83
15987737-3	2005	Using stable CACO-2 transfectants expressing keratin 8 (K8) antisense RNA under a tetracycline-responsive element, we showed that the actin-ezrin scaffold cannot assemble in the absence of intermediate filaments (IFs).	tet	82-94	keratin 8	Mus musculus	45-54
15987737-3	2005	Using stable CACO-2 transfectants expressing keratin 8 (K8) antisense RNA under a tetracycline-responsive element, we showed that the actin-ezrin scaffold cannot assemble in the absence of intermediate filaments (IFs).	tet	82-94	keratin 8	Mus musculus	56-58
15987737-3	2005	Using stable CACO-2 transfectants expressing keratin 8 (K8) antisense RNA under a tetracycline-responsive element, we showed that the actin-ezrin scaffold cannot assemble in the absence of intermediate filaments (IFs).	tet	82-94	ezrin	Mus musculus	140-145
16118410-4	2005	Cofilin is a member of the actin depolymerization factor (ADF)/cofilin family, cofilin cDNA was cloned to a tetracycline-inducible gene expression vector and stably transfected to human lung cancer H1299 epithelial cells.	tet	108-120	cofilin 1	Homo sapiens	0-7
16118410-4	2005	Cofilin is a member of the actin depolymerization factor (ADF)/cofilin family, cofilin cDNA was cloned to a tetracycline-inducible gene expression vector and stably transfected to human lung cancer H1299 epithelial cells.	tet	108-120	cofilin 1	Homo sapiens	79-86
16135802-5	2005	In response to tetracycline, Smad4 expression is effectively silenced.	tet	15-27	SMAD family member 4	Homo sapiens	29-34
15998635-3	2005	MIRA-1 induced mutant p53-dependent cell death in different human tumor cells carrying tetracycline-regulated mutant p53.	tet	87-99	tumor protein p53	Homo sapiens	22-25
15998635-3	2005	MIRA-1 induced mutant p53-dependent cell death in different human tumor cells carrying tetracycline-regulated mutant p53.	tet	87-99	tumor protein p53	Homo sapiens	117-120
16117829-3	2005	Full-length wild-type p53 cDNA obtained by PCR was cloned into a retroviral response vector controlled by the tetracycline responsive element (RevTRE-p53).	tet	110-122	transformation related protein 53, pseudogene	Mus musculus	22-25
16117829-3	2005	Full-length wild-type p53 cDNA obtained by PCR was cloned into a retroviral response vector controlled by the tetracycline responsive element (RevTRE-p53).	tet	110-122	transformation related protein 53, pseudogene	Mus musculus	150-153
16085057-3	2005	Here we used the tetracycline-regulated expression system to overexpress the full-length and truncated forms of Alsin in different cell lines.	tet	17-29	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	112-117
16103410-2	2005	To further characterize its role in this disease process, transgenic mice were generated that express a keratinocyte-specific, tetracycline-inducible TSLP transgene.	tet	127-139	thymic stromal lymphopoietin	Mus musculus	150-154
15817612-6	2005	In this study, we used DLD-1 colorectal cancer cells stably transfected with the POX gene under the control of a tetracycline-inducible promoter.	tet	113-125	proline dehydrogenase 1	Homo sapiens	81-84
16131500-0	2005	Characterization of the degradation of recombinant rat urate oxidase in tetracycline controlled gene expression cells.	tet	72-84	urate oxidase	Rattus norvegicus	55-68
16131500-5	2005	The cells expressing rat UOX were subtly controlled by tetracycline (Tc).	tet	55-67	urate oxidase	Rattus norvegicus	25-28
16131500-5	2005	The cells expressing rat UOX were subtly controlled by tetracycline (Tc).	tet	69-71	urate oxidase	Rattus norvegicus	25-28
16131500-6	2005	High levels of UOX mRNA and protein enzymatic activity were observed when the cells were cultured in the absence of Tc.	tet	116-118	urate oxidase	Rattus norvegicus	15-18
16131500-8	2005	The addition of Tc into the medium led to the halting of rat UOX gene transcription.	tet	16-18	urate oxidase	Rattus norvegicus	61-64
15772935-0	2005	Immune responses against tetracycline-dependent transactivators affect long-term expression of mouse erythropoietin delivered by a helper-dependent adenoviral vector.	tet	25-37	erythropoietin	Mus musculus	101-115
15772935-9	2005	Nonetheless, regulation of mouse EPO secretion was maintained during the entire experimental period, both when the vector dosage was reduced and when the tet-dependent transcription factors were put under the control of a muscle-specific promoter.	tet	154-157	erythropoietin	Mus musculus	33-36
16132700-5	2005	Using a tetracycline-sensitive promoter to regulate tankyrase-1 expression in Madin-Darby canine kidney (MDCK) cells, we found that a 40-fold induction of tankyrase-1 (from 1,500 to 60,000 copies per cell) lowers steady-state NAD(+) levels but does not affect basal cellular viability.	tet	8-20	tankyrase	Canis lupus familiaris	52-63
16132700-5	2005	Using a tetracycline-sensitive promoter to regulate tankyrase-1 expression in Madin-Darby canine kidney (MDCK) cells, we found that a 40-fold induction of tankyrase-1 (from 1,500 to 60,000 copies per cell) lowers steady-state NAD(+) levels but does not affect basal cellular viability.	tet	8-20	tankyrase	Canis lupus familiaris	155-166
16153435-6	2005	METHODS: A tetracycline-responsive adenoviral vector was used to transfect the TNF-alpha gene (Ad-TNF-alpha) into human esophageal cancer cell lines Bic1, Seg1 and TT, as well as in transformed PKR(+/+) and PKR(-/-) early-passage mouse embryo fibroblasts.	tet	11-23	tumor necrosis factor	Homo sapiens	79-88
16153435-6	2005	METHODS: A tetracycline-responsive adenoviral vector was used to transfect the TNF-alpha gene (Ad-TNF-alpha) into human esophageal cancer cell lines Bic1, Seg1 and TT, as well as in transformed PKR(+/+) and PKR(-/-) early-passage mouse embryo fibroblasts.	tet	11-23	tumor necrosis factor	Mus musculus	98-107
16153435-6	2005	METHODS: A tetracycline-responsive adenoviral vector was used to transfect the TNF-alpha gene (Ad-TNF-alpha) into human esophageal cancer cell lines Bic1, Seg1 and TT, as well as in transformed PKR(+/+) and PKR(-/-) early-passage mouse embryo fibroblasts.	tet	11-23	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	194-197
16153435-6	2005	METHODS: A tetracycline-responsive adenoviral vector was used to transfect the TNF-alpha gene (Ad-TNF-alpha) into human esophageal cancer cell lines Bic1, Seg1 and TT, as well as in transformed PKR(+/+) and PKR(-/-) early-passage mouse embryo fibroblasts.	tet	11-23	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	207-210
16153435-12	2005	Inhibition of TNF-alpha expression by tetracycline resulted in downregulation of PKR and decreased apoptosis.	tet	38-50	tumor necrosis factor	Mus musculus	14-23
16153435-12	2005	Inhibition of TNF-alpha expression by tetracycline resulted in downregulation of PKR and decreased apoptosis.	tet	38-50	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	81-84
15800668-3	2005	CCRF-CEM cells with tetracycline-regulated p16(INK4A) expression underwent stable G1-phase cell cycle arrest for 72 h followed by massive apoptosis.	tet	20-32	cyclin dependent kinase inhibitor 2A	Homo sapiens	43-46
15994223-3	2005	We expressed a constitutively active Notch4, int3, in the adult mouse endothelium by using the tetracycline-repressible system to suppress int3 during embryogenesis.	tet	95-107	notch 4	Mus musculus	37-43
15994223-3	2005	We expressed a constitutively active Notch4, int3, in the adult mouse endothelium by using the tetracycline-repressible system to suppress int3 during embryogenesis.	tet	95-107	notch 4	Mus musculus	45-49
15994223-3	2005	We expressed a constitutively active Notch4, int3, in the adult mouse endothelium by using the tetracycline-repressible system to suppress int3 during embryogenesis.	tet	95-107	notch 4	Mus musculus	139-143
16003065-0	2005	Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats.	tet	30-42	transforming growth factor, beta 1	Rattus norvegicus	46-78
16003065-0	2005	Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats.	tet	30-42	caspase 3	Rattus norvegicus	83-92
16029195-4	2005	To overcome these limitations, we established a transgenic mouse model with inducible neuron-specific expression of TGF-beta1 based on the tetracycline-regulated gene expression system.	tet	139-151	transforming growth factor, beta 1	Mus musculus	116-125
15870072-4	2005	We demonstrate the in vivo regulation of the tetracycline-dependent Tet repressor by an oligopeptide fused to the N or C terminus of thioredoxin A.	tet	45-57	thioredoxin	Homo sapiens	133-144
16000874-2	2005	Through a tetracycline-regulated COX-2 overexpression system, we found that COX-2 inhibits detachment-induced apoptosis (anoikis) in a human bladder cancer cell line, EJ.	tet	10-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	33-38
16000874-2	2005	Through a tetracycline-regulated COX-2 overexpression system, we found that COX-2 inhibits detachment-induced apoptosis (anoikis) in a human bladder cancer cell line, EJ.	tet	10-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	76-81
15930281-5	2005	To test whether EWS-FLI1 fusion gene expression is responsible for the primitive neuroectodermal phenotype of EFT, we established a tetracycline-inducible EWS-FLI1 expression system in a rhabdomyosarcoma cell line RD.	tet	132-144	EWS RNA binding protein 1	Homo sapiens	155-158
15930281-5	2005	To test whether EWS-FLI1 fusion gene expression is responsible for the primitive neuroectodermal phenotype of EFT, we established a tetracycline-inducible EWS-FLI1 expression system in a rhabdomyosarcoma cell line RD.	tet	132-144	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	159-163
15950070-5	2005	METHODS: We transfected the human wild-type ER(alpha) to an ER-negative rat epithelial endometrial cell line (Rentr01) using a tetracycline-regulated gene expression system.	tet	127-139	estrogen receptor 1	Homo sapiens	44-53
16202214-6	2005	Using immortalised rat PSCs, we have established a model of tetracycline (tet)-regulated PPARgamma overexpression.	tet	60-72	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	89-98
16202214-6	2005	Using immortalised rat PSCs, we have established a model of tetracycline (tet)-regulated PPARgamma overexpression.	tet	60-63	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	89-98
15953367-4	2005	Tetracycline-based conditional expression of N-myc sensitized microglia to nitric oxide (NO)-induced apoptosis.	tet	0-12	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	45-50
16018756-0	2005	Tetracycline at subcytotoxic levels inhibits matrix metalloproteinase-2 and -9 but does not remove the smear layer.	tet	0-12	matrix metallopeptidase 2	Homo sapiens	45-78
16018756-4	2005	Activity assays measured TCN concentrations with half-maximal inhibition (IC(50)) of matrix metalloproteinase- 2 and -9 (MMP-2 and -9).	tet	25-28	matrix metallopeptidase 2	Homo sapiens	121-133
16018756-6	2005	RESULTS: The TD(50) for TCN after short-term treatment was 4 mg/ml for both hGF and hPDL.	tet	24-27	hepatocyte growth factor	Homo sapiens	76-79
16018756-6	2005	RESULTS: The TD(50) for TCN after short-term treatment was 4 mg/ml for both hGF and hPDL.	tet	24-27	programmed cell death 1	Homo sapiens	84-88
16018756-13	2005	Since non-cytotoxic concentrations of TCN inhibited MMP-2 and -9 but had no effects on the smear layer, TCN is not recommended for root surface treatment.	tet	38-41	matrix metallopeptidase 2	Homo sapiens	52-64
15988001-6	2005	Tetracycline-inducible expression of REDD1 triggers rapid dephosphorylation of S6K and 4E-BP1 and significantly decreases cellular size.	tet	0-12	DNA damage inducible transcript 4	Homo sapiens	37-42
15988001-6	2005	Tetracycline-inducible expression of REDD1 triggers rapid dephosphorylation of S6K and 4E-BP1 and significantly decreases cellular size.	tet	0-12	ribosomal protein S6 kinase B1	Homo sapiens	79-93
15896326-1	2005	To estimate the turnover of UDP-N-acetylglucosaminyl transferase (OGT), we exposed stably transfected HeLa cells to tetracycline for 16h to induce OGT gene expression and increase cytosolic enzyme levels.	tet	116-128	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	66-69
15896326-1	2005	To estimate the turnover of UDP-N-acetylglucosaminyl transferase (OGT), we exposed stably transfected HeLa cells to tetracycline for 16h to induce OGT gene expression and increase cytosolic enzyme levels.	tet	116-128	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	147-150
15896326-2	2005	Removal of tetracycline led to a progressive decrease in OGT activity (after a 6h lag period), yielding an estimated OGT half-life of 13h.	tet	11-23	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	57-60
15896326-2	2005	Removal of tetracycline led to a progressive decrease in OGT activity (after a 6h lag period), yielding an estimated OGT half-life of 13h.	tet	11-23	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	117-120
15995625-4	2005	METHODS: Tet-on LMP1 HNE2, a tetracycline-regulated LMP1-expression nasopharyngeal carcinoma cell line, was used as cell model.	tet	29-41	PDZ and LIM domain 7	Homo sapiens	52-56
15800668-3	2005	CCRF-CEM cells with tetracycline-regulated p16(INK4A) expression underwent stable G1-phase cell cycle arrest for 72 h followed by massive apoptosis.	tet	20-32	cyclin dependent kinase inhibitor 2A	Homo sapiens	47-52
15907481-3	2005	A tetracycline-inducible system for IRF-1 revealed its function in the LMP7 expression, and a genomic region functionally interacting with IRF-1 was also determined.	tet	2-14	interferon regulatory factor 1	Mus musculus	36-41
15866713-7	2005	We demonstrate applicability of the vector system by expression of the largest DMBT1 variant in a tetracycline-inducible mammalian expression system using the Chinese hamster ovary cell line.	tet	98-110	deleted in malignant brain tumors 1	Homo sapiens	79-84
15907481-3	2005	A tetracycline-inducible system for IRF-1 revealed its function in the LMP7 expression, and a genomic region functionally interacting with IRF-1 was also determined.	tet	2-14	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	Mus musculus	71-75
15907481-3	2005	A tetracycline-inducible system for IRF-1 revealed its function in the LMP7 expression, and a genomic region functionally interacting with IRF-1 was also determined.	tet	2-14	interferon regulatory factor 1	Mus musculus	139-144
15828000-0	2005	Transgenic mice carrying a tetracycline-inducible, truncated transforming growth factor beta receptor (TbetaRII).	tet	27-39	transforming growth factor, beta receptor II	Mus musculus	103-111
15820209-7	2005	RESULTS: Gel contraction was significantly reduced at all times when MMP-9 was overexpressed (Tet-) as compared with the control condition (Tet+).	tet	94-97	matrix metallopeptidase 9	Rattus norvegicus	69-74
15901346-8	2005	A wide range of structurally unrelated organic compounds inhibited the hOat2-mediated uptake of tetracycline, except for sulfobromophthalein.	tet	96-108	solute carrier family 22 member 7	Homo sapiens	71-76
15831458-2	2005	To elucidate the functions of CKIP-1, we generated human osteosarcoma cell lines with tetracycline-regulated expression of Flag-CKIP-1.	tet	86-98	pleckstrin homology domain containing O1	Homo sapiens	30-36
15831458-2	2005	To elucidate the functions of CKIP-1, we generated human osteosarcoma cell lines with tetracycline-regulated expression of Flag-CKIP-1.	tet	86-98	pleckstrin homology domain containing O1	Homo sapiens	128-134
15851015-5	2005	We showed that hF.IX expression in the plasma could be expressed to therapeutically significant concentrations, adjusted to different set levels by varying the tetracycline dose, rapidly turned off and on, and completely recovered after each treatment cycle.	tet	160-172	coagulation factor IX	Homo sapiens	15-20
15870295-4	2005	Conversely, conditional expression of a moderate but not maximal level of Hes1 in HeLa cells by a tetracycline-inducible system resulted in reduced p27(Kip1) expression, which was attributed to decreased basal transcript rather than enhanced proteasomal degradation, with concomitant increases in the growth rate and saturation density.	tet	98-110	zinc ribbon domain containing 2	Homo sapiens	148-151
15870295-4	2005	Conversely, conditional expression of a moderate but not maximal level of Hes1 in HeLa cells by a tetracycline-inducible system resulted in reduced p27(Kip1) expression, which was attributed to decreased basal transcript rather than enhanced proteasomal degradation, with concomitant increases in the growth rate and saturation density.	tet	98-110	cyclin dependent kinase inhibitor 1B	Homo sapiens	152-156
15809749-4	2005	We examined the signaling cascades of VEGFR-1 and VEGFR-2 in the VEGF-mediated HCC development in combination with a retroviral tetracycline (tet)-regulated (Retro-Tet) gene expression system, which can manipulate the gene expression in vivo by providing tet in the drinking water, as well as VEGFR-1 and VEGFR-2 specific neutralizing monoclonal antibodies (R-1mAb and R-2mAb, respectively).	tet	142-145	FMS-like tyrosine kinase 1	Mus musculus	293-300
15809749-4	2005	We examined the signaling cascades of VEGFR-1 and VEGFR-2 in the VEGF-mediated HCC development in combination with a retroviral tetracycline (tet)-regulated (Retro-Tet) gene expression system, which can manipulate the gene expression in vivo by providing tet in the drinking water, as well as VEGFR-1 and VEGFR-2 specific neutralizing monoclonal antibodies (R-1mAb and R-2mAb, respectively).	tet	142-145	kinase insert domain protein receptor	Mus musculus	305-312
15722553-3	2005	In this study, we used a tetracycline-regulated cell line expressing an NF-kappaB inhibitor to systematically identify NF-kappaB-dependent genes.	tet	25-37	nuclear factor kappa B subunit 1	Homo sapiens	72-81
15722553-3	2005	In this study, we used a tetracycline-regulated cell line expressing an NF-kappaB inhibitor to systematically identify NF-kappaB-dependent genes.	tet	25-37	nuclear factor kappa B subunit 1	Homo sapiens	119-128
15735690-3	2005	To investigate the potential role of SLUG overexpression in development and in cancer, we generated mice carrying a tetracycline-repressible Slug transgene.	tet	116-128	snail family zinc finger 2	Mus musculus	141-145
15858061-7	2005	Constitutive ectopic expression of aldolases A and C accelerates the decay of a neurofilament transgene (NF-L) driven by a tetracycline inducible system.	tet	123-135	neurofilament, light polypeptide	Mus musculus	105-109
15780980-4	2005	An expression vector with a tetracycline-responsive promoter driving FLAG-tagged Cdk9(55) and a HeLa 37 Tet-Off cell line were constructed.	tet	28-40	cyclin dependent kinase 9	Homo sapiens	81-85
15735719-0	2005	Conditional inhibition of cancer cell proliferation by tetracycline-responsive, H1 promoter-driven silencing of PLK1.	tet	55-67	polo like kinase 1	Homo sapiens	112-116
15796985-5	2005	ESBL production was associated with high levels of resistance to tetracycline, sulfisoxazole, streptomycin, kanamycin, gentamicin and tobramycin when compared to non-ESBL producing isolates.	tet	65-77	EsbL	Escherichia coli	0-4
16032782-7	2005	Transiently increased gamma-GCSh expression using tetracycline-inducible gamma-GCSh adenoviral expression system also showed down-regulation of MMP3 and MMP10, but not MMP1.	tet	50-62	glutamate-cysteine ligase catalytic subunit	Homo sapiens	22-32
16032782-7	2005	Transiently increased gamma-GCSh expression using tetracycline-inducible gamma-GCSh adenoviral expression system also showed down-regulation of MMP3 and MMP10, but not MMP1.	tet	50-62	glutamate-cysteine ligase catalytic subunit	Homo sapiens	73-83
15743796-4	2005	To examine temporal expression of Tie2, we have developed a binary transgenic approach whereby expression of Tie2 can be conditionally regulated by the presence of tetracycline analogs in double-transgenic mice.	tet	164-176	TEK receptor tyrosine kinase	Mus musculus	109-113
15743796-7	2005	These skin abnormalities resolved completely with tetracycline-mediated suppression of transgene expression, thereby illustrating a complete dependence on Tie2 signaling for disease maintenance and progression.	tet	50-62	TEK receptor tyrosine kinase	Mus musculus	155-159
15772148-8	2005	Five tetracycline-resistant isolates had no PCR evidence of orf1 and orf2 and showed variable patterns as to orf3, orf7, and orf8.	tet	5-17	hypothetical protein	Streptococcus pyogenes	109-113
15816843-5	2005	Using a tetracycline-regulated expression system, we also confirmed that the suppression of cell proliferation was dependent on the expression level of T-cadherin.	tet	8-20	cadherin 13	Homo sapiens	152-162
15821105-0	2005	Tetracycline-regulated secretion of human (pro)insulin following plasmid-mediated transfection of human muscle.	tet	0-12	insulin	Homo sapiens	47-54
15821105-3	2005	Liposomal co-transfection with a tetracycline-responsive wild type human preproinsulin (pTRE-hppI1) or mutant construct (pTRE-hppI4), in which PC2 and PC3 cleavage sites were altered to form tetrabasic consensus sites for furin, together with pTet-off (coding for a transactivating protein) was evaluated in the C2C12 mouse myoblast cell line and human myoblasts following establishment in primary culture.	tet	33-45	insulin	Homo sapiens	73-86
15821105-6	2005	Incremental dose-responsive suppression of proinsulin secretion was demonstrated in C2C12 and human myoblasts expressing pTet-off/pTRE-hppI1 following incubation with tetracycline (0-100 microg/ml) for up to 72 h. Reversibility was confirmed following tetracycline withdrawal.	tet	167-179	insulin	Homo sapiens	43-53
15821105-6	2005	Incremental dose-responsive suppression of proinsulin secretion was demonstrated in C2C12 and human myoblasts expressing pTet-off/pTRE-hppI1 following incubation with tetracycline (0-100 microg/ml) for up to 72 h. Reversibility was confirmed following tetracycline withdrawal.	tet	252-264	insulin	Homo sapiens	43-53
15821105-8	2005	Regulation of human proinsulin biosynthesis and secretion has been attained in vivo following plasmid-mediated gene transfer to rat skeletal muscle and oral tetracycline administration.	tet	157-169	insulin	Homo sapiens	20-30
15821105-9	2005	In conclusion, processing to mature insulin has been confirmed following plasmid-mediated gene transfer to human muscle in addition to in vitro- and in vivo-regulated human proinsulin secretion employing the safe and well-tolerated antibiotic, tetracycline.	tet	244-256	insulin	Homo sapiens	36-43
15821105-9	2005	In conclusion, processing to mature insulin has been confirmed following plasmid-mediated gene transfer to human muscle in addition to in vitro- and in vivo-regulated human proinsulin secretion employing the safe and well-tolerated antibiotic, tetracycline.	tet	244-256	insulin	Homo sapiens	173-183
15769877-3	2005	Chemical and enzymatic probing reveals that the aptamer consists of two stems, P1 and P2, which are already present in the absence of tc and form the scaffold of the aptamer.	tet	134-136	crystallin gamma F, pseudogene	Homo sapiens	79-88
15826908-4	2005	Since constitutive expression of BARF1 from this heterologous system became inefficient, we developed a tetracycline-regulatable recombinant vector expressing BARF1 and green fluorescent protein from a dicistronic message.	tet	104-116	BaRF1	Human gammaherpesvirus 4	33-38
15826908-4	2005	Since constitutive expression of BARF1 from this heterologous system became inefficient, we developed a tetracycline-regulatable recombinant vector expressing BARF1 and green fluorescent protein from a dicistronic message.	tet	104-116	BaRF1	Human gammaherpesvirus 4	159-164
15688030-6	2005	Here, we applied the FOXO4 gene as a novel anticancer agent for HER2-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	113-125	forkhead box O4	Homo sapiens	21-26
15688030-6	2005	Here, we applied the FOXO4 gene as a novel anticancer agent for HER2-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	113-125	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
15688030-6	2005	Here, we applied the FOXO4 gene as a novel anticancer agent for HER2-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	113-116	forkhead box O4	Homo sapiens	21-26
15688030-6	2005	Here, we applied the FOXO4 gene as a novel anticancer agent for HER2-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	113-116	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
15647773-4	2005	To do this, we have developed lines from the estrogen-responsive MCF-7 breast cancer cell line in which the expression of the fusion protein PLZF-ERalpha is conditionally regulated by tetracycline and shows that these feature long-term silencing of the expression of several well-characterized estrogen-regulated genes, namely pS2, cathepsin-D and the progesterone receptor.	tet	184-196	zinc finger and BTB domain containing 16	Homo sapiens	141-145
15647773-4	2005	To do this, we have developed lines from the estrogen-responsive MCF-7 breast cancer cell line in which the expression of the fusion protein PLZF-ERalpha is conditionally regulated by tetracycline and shows that these feature long-term silencing of the expression of several well-characterized estrogen-regulated genes, namely pS2, cathepsin-D and the progesterone receptor.	tet	184-196	estrogen receptor 1	Homo sapiens	146-153
16032782-7	2005	Transiently increased gamma-GCSh expression using tetracycline-inducible gamma-GCSh adenoviral expression system also showed down-regulation of MMP3 and MMP10, but not MMP1.	tet	50-62	matrix metallopeptidase 3	Homo sapiens	144-148
16032782-7	2005	Transiently increased gamma-GCSh expression using tetracycline-inducible gamma-GCSh adenoviral expression system also showed down-regulation of MMP3 and MMP10, but not MMP1.	tet	50-62	matrix metallopeptidase 10	Homo sapiens	153-158
16032782-7	2005	Transiently increased gamma-GCSh expression using tetracycline-inducible gamma-GCSh adenoviral expression system also showed down-regulation of MMP3 and MMP10, but not MMP1.	tet	50-62	matrix metallopeptidase 1	Homo sapiens	153-157
15578580-7	2005	Tetracycline-regulatable overexpression of necdin induced growth arrest of SAOS-2 cells in a reversible manner, and the necdin-overexpressing cells showed a large, flattened morphology with double nuclei.	tet	0-12	necdin, MAGE family member	Homo sapiens	43-49
15607822-2	2005	To identify LKLF-regulated genes, we performed microarray analysis using an established Jurkat T cell line containing a tetracycline-inducible LKLF.	tet	120-132	Kruppel like factor 2	Homo sapiens	12-16
15607822-2	2005	To identify LKLF-regulated genes, we performed microarray analysis using an established Jurkat T cell line containing a tetracycline-inducible LKLF.	tet	120-132	Kruppel like factor 2	Homo sapiens	143-147
15741176-3	2005	Here, we report our development of the ROSA-TET system, an effective system for the establishment of multiple ES cell lines carrying a tetracycline (Tc)-regulatable transgene at the Gt (ROSA)26asSor (ROSA26) locus.	tet	135-147	THUMP domain containing 3	Mus musculus	182-198
15713645-1	2005	To explore the role of mPer2 in the circadian oscillation in the mammalian cellular clock, we established fibroblast cell lines in which expression of mPer2 is controlled through a tetracycline-regulatable promoter.	tet	181-193	period circadian clock 2	Mus musculus	151-156
15649408-3	2005	As an alternative, we used a novel immortalization vector with a tetracycline-regulated expression of the wild-type TAg.	tet	65-77	long intergenic non-protein coding RNA 1194	Homo sapiens	116-119
15701171-1	2005	A conditional-lethal recombinant virus was constructed in which the expression of the vaccinia virus I7L gene is under the control of the tetracycline operator/repressor system.	tet	138-150	viral core cysteine proteinase	Vaccinia virus	101-104
15660114-2	2005	Previously, we have developed a complex adenovirus (Ad) vector with tetracycline-regulated expression of a Fas ligand (FasL)-green fluorescent protein (GFP) fusion protein.	tet	68-80	Fas ligand (TNF superfamily, member 6)	Mus musculus	107-117
15660114-2	2005	Previously, we have developed a complex adenovirus (Ad) vector with tetracycline-regulated expression of a Fas ligand (FasL)-green fluorescent protein (GFP) fusion protein.	tet	68-80	Fas ligand (TNF superfamily, member 6)	Mus musculus	119-123
15735022-4	2005	Similar mitotic aberrations were also observed in a panel of BL lines and were suppressed, in parallel with TPP II down-regulation, upon reversion of BL-like characteristics in EBV-immortalized B lymphocytes carrying a tetracycline-regulated c-myc.	tet	219-231	tripeptidyl peptidase 2	Homo sapiens	108-114
15735022-4	2005	Similar mitotic aberrations were also observed in a panel of BL lines and were suppressed, in parallel with TPP II down-regulation, upon reversion of BL-like characteristics in EBV-immortalized B lymphocytes carrying a tetracycline-regulated c-myc.	tet	219-231	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	242-247
15525642-5	2005	To investigate this question, we generated an Epstein-Barr virus-negative Burkitts lymphoma line that expresses LANA from a tetracycline-inducible promoter (BJAB/Tet-On/LANA), and we performed microarray-based gene expression profiling.	tet	124-136	LANA	Human gammaherpesvirus 8	112-116
15741176-3	2005	Here, we report our development of the ROSA-TET system, an effective system for the establishment of multiple ES cell lines carrying a tetracycline (Tc)-regulatable transgene at the Gt (ROSA)26asSor (ROSA26) locus.	tet	149-151	THUMP domain containing 3	Mus musculus	182-198
15741176-3	2005	Here, we report our development of the ROSA-TET system, an effective system for the establishment of multiple ES cell lines carrying a tetracycline (Tc)-regulatable transgene at the Gt (ROSA)26asSor (ROSA26) locus.	tet	149-151	gene trap ROSA 26, Philippe Soriano	Mus musculus	200-206
15705882-5	2005	In contrast to previous observations based on constitutively overexpressing cell lines, P21 induced by tetracycline-regulated ERBB2 localizes to the nucleus in arrested cells.	tet	103-115	cyclin dependent kinase inhibitor 1A	Homo sapiens	88-91
15705882-5	2005	In contrast to previous observations based on constitutively overexpressing cell lines, P21 induced by tetracycline-regulated ERBB2 localizes to the nucleus in arrested cells.	tet	103-115	erb-b2 receptor tyrosine kinase 2	Homo sapiens	126-131
15629764-0	2005	A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo.	tet	2-14	caspase 9	Rattus norvegicus	63-72
15629764-2	2005	In this study, we determined that a tetracycline-regulated adenovirus harboring a dominant-negative form of caspase-9 (Casp9DN) and the marker gene, enhanced green fluorescent protein (EGFP), under the control of a bidirectional promoter could each be regulated in vitro and in vivo by doxycycline.	tet	36-48	caspase 9	Rattus norvegicus	108-117
15496960-4	2005	Tetracycline-regulated ribozyme expression vectors were used to deplete conditionally PTN mRNA from melanoma xenograft tumors in vivo.	tet	0-12	pleiotrophin	Mus musculus	86-89
15653413-4	2005	STUDY DESIGN: Huh-7 cells with tight regulated expression of the HBV core or precore protein were produced using the Tet-Off tetracycline gene expression system.	tet	125-137	MIR7-3 host gene	Homo sapiens	14-19
15695400-7	2005	Reducing CLIC proteins in tumor grafts of SP1 cells expressing a tetracycline-regulated CLIC4-antisense substantially inhibited tumor growth and induced tumor apoptosis.	tet	65-77	chloride intracellular channel 4	Homo sapiens	88-93
15509588-7	2005	Finally, a tetracycline-inducible expression model allowed us to confirm the central role of these PKC isoforms and the negative regulatory function of c-Src in the control of ST3 expression.	tet	11-23	protein kinase C alpha	Homo sapiens	99-102
15509588-7	2005	Finally, a tetracycline-inducible expression model allowed us to confirm the central role of these PKC isoforms and the negative regulatory function of c-Src in the control of ST3 expression.	tet	11-23	matrix metallopeptidase 11	Homo sapiens	176-179
15531922-6	2005	In order to study the influence of Bcl-2 on TRAIL-induced cell death more detailed, we utilized a tetracycline-regulated Bcl-2 expression system in Jurkat T cells.	tet	98-110	TNF superfamily member 10	Homo sapiens	44-49
15531922-6	2005	In order to study the influence of Bcl-2 on TRAIL-induced cell death more detailed, we utilized a tetracycline-regulated Bcl-2 expression system in Jurkat T cells.	tet	98-110	BCL2 apoptosis regulator	Homo sapiens	121-126
15629222-4	2005	The ESBL-positive K. pneumoniae isolates were resistant to aztreonam, ceftazidime, aminoglycosides, and trimethoprim/sulfamethoxazole and susceptible to ciprofloxacin and tetracycline.	tet	171-183	CTX-M-15	Klebsiella pneumoniae	4-8
15599784-7	2005	In addition to resistance to oxacillin, the strains exhibited resistance to ciprofloxacin, tetracycline (tetM), and fusidic acid, the last of which is encoded by the far-1 gene.	tet	91-103	Far1	Staphylococcus aureus	166-171
15633123-7	2005	A colorectal cancer cell clone capable of inducing actinin-4 using the tetracycline-regulatory system (designated DLD1 Tet-off ACTN-4) was established.	tet	71-83	actinin alpha 4	Homo sapiens	51-60
15633123-7	2005	A colorectal cancer cell clone capable of inducing actinin-4 using the tetracycline-regulatory system (designated DLD1 Tet-off ACTN-4) was established.	tet	71-83	actinin alpha 4	Homo sapiens	127-133
15499652-8	2005	CONCLUSIONS: Reversal of the silencing of a tetracycline-regulated minimal promoter requires a chromatin-remodeling activity for subsequent promoter activation by the Tet-VP16 fusion protein.	tet	44-56	host cell factor C1	Homo sapiens	171-175
15502192-5	2005	As an example of this methodology, we discuss our recently developed keratinocyte cell lines that express human filaggrin in a tetracycline- regulated manner.	tet	127-139	filaggrin	Homo sapiens	112-121
15705859-1	2005	A conditional tetracycline-responsive transgenic mouse model with deregulated estrogen receptor alpha expression in mammary epithelial cells developed ductal hyperplasia (DH), lobular hyperplasia, and ductal carcinoma in situ (DCIS) by 4 months of age.	tet	14-26	estrogen receptor 1 (alpha)	Mus musculus	78-101
15613247-11	2004	However, experimental tetracycline dependent induction of WT1 in SAOS osteosarcoma cells did not influence GP210 transcription.	tet	22-34	WT1 transcription factor	Homo sapiens	58-61
15632084-3	2005	Using a fibroblast model in which the expression of either MKP-3 or a more stable MKP-3-green fluorescent protein (GFP) chimera was induced by tetracycline, we found that serum induces the phosphorylation of MKP-3 and its subsequent degradation by the proteasome in a MEK1 and MEK2 (MEK1/2)-ERK1/2-dependent manner.	tet	143-155	dual specificity phosphatase 6	Homo sapiens	59-64
15632084-3	2005	Using a fibroblast model in which the expression of either MKP-3 or a more stable MKP-3-green fluorescent protein (GFP) chimera was induced by tetracycline, we found that serum induces the phosphorylation of MKP-3 and its subsequent degradation by the proteasome in a MEK1 and MEK2 (MEK1/2)-ERK1/2-dependent manner.	tet	143-155	dual specificity phosphatase 6	Homo sapiens	82-87
15632084-3	2005	Using a fibroblast model in which the expression of either MKP-3 or a more stable MKP-3-green fluorescent protein (GFP) chimera was induced by tetracycline, we found that serum induces the phosphorylation of MKP-3 and its subsequent degradation by the proteasome in a MEK1 and MEK2 (MEK1/2)-ERK1/2-dependent manner.	tet	143-155	dual specificity phosphatase 6	Homo sapiens	82-87
15632084-5	2005	Tetracycline-inducible cell clones expressing either single or double serine mutants of MKP-3 or MKP-3-GFP confirmed that these two sites are targeted by the MEK1/2-ERK1/2 module in vivo.	tet	0-12	dual specificity phosphatase 6	Homo sapiens	88-93
15632084-5	2005	Tetracycline-inducible cell clones expressing either single or double serine mutants of MKP-3 or MKP-3-GFP confirmed that these two sites are targeted by the MEK1/2-ERK1/2 module in vivo.	tet	0-12	dual specificity phosphatase 6	Homo sapiens	97-102
15632084-5	2005	Tetracycline-inducible cell clones expressing either single or double serine mutants of MKP-3 or MKP-3-GFP confirmed that these two sites are targeted by the MEK1/2-ERK1/2 module in vivo.	tet	0-12	mitogen-activated protein kinase kinase 2	Homo sapiens	158-164
15632084-5	2005	Tetracycline-inducible cell clones expressing either single or double serine mutants of MKP-3 or MKP-3-GFP confirmed that these two sites are targeted by the MEK1/2-ERK1/2 module in vivo.	tet	0-12	mitogen-activated protein kinase 3	Homo sapiens	165-171
15596355-1	2005	To provide an in vitro system that allows inducible or conditional overexpression of human prion protein (PrP), we have established a tetracycline (Tc)-regulated system in murine 3T3 L1 fibroblast cells.	tet	134-146	prion protein	Homo sapiens	106-109
15596355-1	2005	To provide an in vitro system that allows inducible or conditional overexpression of human prion protein (PrP), we have established a tetracycline (Tc)-regulated system in murine 3T3 L1 fibroblast cells.	tet	148-150	prion protein	Homo sapiens	106-109
15596355-5	2005	Addition of the antibiotic Tc to the culture medium turned off expression of human PrP.	tet	27-29	prion protein	Homo sapiens	83-86
15596355-8	2005	In the absence of Tc, expression of human PrP was induced 10- to 20-fold as estimated from densitometric analyses.	tet	18-20	prion protein	Homo sapiens	42-45
15625130-3	2005	Using our co-culture system with stromal cells, we demonstrate that enforced expression of the transcription factor PU.1 under tetracycline control in Tal1-null embryonic stem (ES) cells rescues the development of osteoclasts and macrophage-like phagocytes.	tet	127-139	spleen focus forming virus (SFFV) proviral integration oncogene	Mus musculus	116-120
15625130-3	2005	Using our co-culture system with stromal cells, we demonstrate that enforced expression of the transcription factor PU.1 under tetracycline control in Tal1-null embryonic stem (ES) cells rescues the development of osteoclasts and macrophage-like phagocytes.	tet	127-139	T cell acute lymphocytic leukemia 1	Mus musculus	151-155
15531927-7	2004	activin receptor-like kinase (ALK)-6) in a tetracycline (Tet)-regulated manner.	tet	43-55	bone morphogenetic protein receptor type 1B	Homo sapiens	0-36
15531927-7	2004	activin receptor-like kinase (ALK)-6) in a tetracycline (Tet)-regulated manner.	tet	57-60	bone morphogenetic protein receptor type 1B	Homo sapiens	0-36
15531927-8	2004	Tet/doxycycline-regulated expression of c.a.ALK-6 resulted in the inhibition of in vitro cell proliferation and reduction of the size of tumors derived from the PC-3 cells subcutaneously injected into immune-deficient mice.	tet	0-3	bone morphogenetic protein receptor, type 1B	Mus musculus	44-49
15506943-9	2004	When several human tumour cell lines were genetically engineered to conditionally express CX43 under the influence of a tetracycline promoter, their neoplastic phenotype was strongly attenuated.	tet	120-132	gap junction protein alpha 1	Homo sapiens	90-94
15669184-0	2004	A single tetracycline-regulated vector devised for controlled insulin gene expression.	tet	9-21	insulin	Homo sapiens	62-69
15555926-1	2004	Here we examined the role of interferon (IFN)-gamma in regulating the Sonic hedgehog (Shh) pathway and cerebellar development in bigenic mice with temporal control of IFN-gamma gene expression driven by a tetracycline-controllable promoter.	tet	205-217	interferon gamma	Mus musculus	167-176
15468174-3	2004	Recently we have generated a new line of IGF-I Tg mice, called IGF-I(Ast/Tet-Off) Tg mice, in which IGF-I transgene is expressed specifically in astrocytes and is tightly controlled by the tetracycline analog doxycycline.	tet	189-201	insulin-like growth factor 1	Mus musculus	41-46
15468174-3	2004	Recently we have generated a new line of IGF-I Tg mice, called IGF-I(Ast/Tet-Off) Tg mice, in which IGF-I transgene is expressed specifically in astrocytes and is tightly controlled by the tetracycline analog doxycycline.	tet	189-201	insulin-like growth factor 1	Mus musculus	63-68
15468174-3	2004	Recently we have generated a new line of IGF-I Tg mice, called IGF-I(Ast/Tet-Off) Tg mice, in which IGF-I transgene is expressed specifically in astrocytes and is tightly controlled by the tetracycline analog doxycycline.	tet	189-201	transmembrane protease, serine 11d	Mus musculus	69-72
15468174-3	2004	Recently we have generated a new line of IGF-I Tg mice, called IGF-I(Ast/Tet-Off) Tg mice, in which IGF-I transgene is expressed specifically in astrocytes and is tightly controlled by the tetracycline analog doxycycline.	tet	189-201	insulin-like growth factor 1	Mus musculus	63-68
15537876-2	2004	These animals ectopically express interferon-gamma (IFN-gamma) in astrocytes in the CNS in a controlled manner, exploiting the tetracycline-controllable system.	tet	127-139	interferon gamma	Mus musculus	34-50
15537876-2	2004	These animals ectopically express interferon-gamma (IFN-gamma) in astrocytes in the CNS in a controlled manner, exploiting the tetracycline-controllable system.	tet	127-139	interferon gamma	Mus musculus	52-61
15256372-3	2004	To test this hypothesis, we generated a binary transgenic (BTG) system that allows tetracycline-inducible, cardiac-specific SERCA2a expression.	tet	83-95	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	124-131
15666843-2	2004	To bypass the early embryonic lethality of Prkar1a-/- mice, we established transgenic mice carrying an antisense transgene for Prkar1a exon 2 (X2AS) under the control of a tetracycline-responsive promoter.	tet	172-184	protein kinase, cAMP dependent regulatory, type I, alpha	Mus musculus	127-134
15493017-0	2004	Sox10-rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes.	tet	26-38	SRY (sex determining region Y)-box 10	Mus musculus	0-5
15297607-3	2004	We generated stable transfectants that express gcnf sense or antisense RNA under the control of a tetracycline-regulated promoter.	tet	98-110	nuclear receptor subfamily 6, group A, member 1	Mus musculus	47-51
15489642-0	2004	Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis.	tet	28-40	tumor necrosis factor	Rattus norvegicus	44-53
15489642-2	2004	In this study, we focused on the regulation of tumor necrosis factor (TNF)-alpha and mitogen-activated protein kinases (MAPKs) in sepsis and their reduction by treatment with nonantimicrobial chemically modified tetracycline-3 (CMT-3), which retains their antiinflammatory activity.	tet	212-224	tumor necrosis factor	Rattus norvegicus	47-80
15555430-6	2004	Tetracycline was used to regulate the expression of PLP-Ig, and Western blot was used to detect the gene expression.	tet	0-12	proteolipid protein (myelin) 1	Mus musculus	52-55
15555430-7	2004	RESULTS: The expression of PLP-Ig was confirmed by Western blot and its expression could be regulated by tetracycline.	tet	105-117	proteolipid protein (myelin) 1	Mus musculus	27-30
15381082-2	2004	To further study the potential roles of TR4 during cell differentiation, a tetracycline-inducible system with anti-sense TR4 in teratocarcinoma P19 cell lines was generated to analyze the retinoic acid-induced differentiation of these cells.	tet	75-87	nuclear receptor subfamily 2 group C member 2	Homo sapiens	121-124
15361832-2	2004	We used a tetracycline-inducible system in Jurkat T leukemia cells to study the biological role of KLF2 in cellular growth and differentiation.	tet	10-22	Kruppel like factor 2	Homo sapiens	99-103
15242349-0	2004	Tetracycline-regulated expression enables purification and functional analysis of recombinant connexin channels from mammalian cells.	tet	0-12	LOC100128922	Homo sapiens	94-102
15606501-3	2004	Here, two complementary approaches were used to better resolve the molecular determinants for Dsg1-mediated adhesion: (1) a tetracycline-inducible system was used to modulate the levels of Dsg1 expressed in L cell lines containing desmocollin 1 (Dsc1) and plakoglobin (PG) and (2) a retroviral gene delivery system was used to introduce Dsg1 into normal human epidermal keratinocytes (NHEK).	tet	124-136	desmoglein 1	Homo sapiens	94-98
15606501-3	2004	Here, two complementary approaches were used to better resolve the molecular determinants for Dsg1-mediated adhesion: (1) a tetracycline-inducible system was used to modulate the levels of Dsg1 expressed in L cell lines containing desmocollin 1 (Dsc1) and plakoglobin (PG) and (2) a retroviral gene delivery system was used to introduce Dsg1 into normal human epidermal keratinocytes (NHEK).	tet	124-136	desmoglein 1	Homo sapiens	189-193
15606501-3	2004	Here, two complementary approaches were used to better resolve the molecular determinants for Dsg1-mediated adhesion: (1) a tetracycline-inducible system was used to modulate the levels of Dsg1 expressed in L cell lines containing desmocollin 1 (Dsc1) and plakoglobin (PG) and (2) a retroviral gene delivery system was used to introduce Dsg1 into normal human epidermal keratinocytes (NHEK).	tet	124-136	desmoglein 1	Homo sapiens	189-193
15585109-0	2004	Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector.	tet	93-105	glial cell derived neurotrophic factor	Rattus norvegicus	22-65
15385523-2	2004	Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.	tet	45-57	perforin 1 (pore forming protein)	Mus musculus	174-183
15563594-6	2004	By using UBR60 cells, which carry tetracycline-regulated expression of BRCA1, we demonstrated that BRCA1 binds to transcription factor OCT-1 and up-regulates the transcription of MAD2.	tet	34-46	breast cancer 1, early onset	Mus musculus	71-76
15563594-6	2004	By using UBR60 cells, which carry tetracycline-regulated expression of BRCA1, we demonstrated that BRCA1 binds to transcription factor OCT-1 and up-regulates the transcription of MAD2.	tet	34-46	breast cancer 1, early onset	Mus musculus	99-104
15563594-6	2004	By using UBR60 cells, which carry tetracycline-regulated expression of BRCA1, we demonstrated that BRCA1 binds to transcription factor OCT-1 and up-regulates the transcription of MAD2.	tet	34-46	POU domain, class 2, transcription factor 1	Mus musculus	135-140
15563594-6	2004	By using UBR60 cells, which carry tetracycline-regulated expression of BRCA1, we demonstrated that BRCA1 binds to transcription factor OCT-1 and up-regulates the transcription of MAD2.	tet	34-46	MAD2 mitotic arrest deficient-like 1	Mus musculus	179-183
15315937-4	2004	In this paper, we have used primary tubular epithelial cell cultures from a tetracycline-inducible-Hif-1alpha knockout murine model to further elucidate the role of Hif-1 in the hypoxic-induction of Ctgf expression.	tet	76-88	hypoxia inducible factor 1, alpha subunit	Mus musculus	99-109
15315937-4	2004	In this paper, we have used primary tubular epithelial cell cultures from a tetracycline-inducible-Hif-1alpha knockout murine model to further elucidate the role of Hif-1 in the hypoxic-induction of Ctgf expression.	tet	76-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-104
15684704-7	2004	Our results show tetracycline-mediated inhibition of p300 mRNA and protein accumulation in the presence of both viruses, but no effect in the absence of antibiotic.	tet	17-29	E1A binding protein p300	Homo sapiens	53-57
15522720-3	2004	Based on the recognition property of the multiple tetracycline imprinted polymer (MIP-1), the polymer was applied in affinity membrane extraction as a class-selective adsorption phase to remove tetracyclines residues from water.	tet	50-62	transportin 1	Homo sapiens	82-87
15564574-4	2004	In this study, we use a tripartite transgenic system combining GAL4/UAS with the tetracycline-off system to spatially and temporally manipulate levels of Ca2+-independent CaMKII activity in Drosophila.	tet	81-93	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	171-177
15477012-3	2004	INS-1 cells, engineered with the potential for overexpression of glucokinase under the control of a tetracycline-inducible gene expression system, took up and reduced dehydroascorbic acid to ascorbate in a concentration-dependent manner that was optimal in the presence of physiologic D-glucose concentrations.	tet	100-112	insulin 1	Rattus norvegicus	0-5
15477012-3	2004	INS-1 cells, engineered with the potential for overexpression of glucokinase under the control of a tetracycline-inducible gene expression system, took up and reduced dehydroascorbic acid to ascorbate in a concentration-dependent manner that was optimal in the presence of physiologic D-glucose concentrations.	tet	100-112	glucokinase	Rattus norvegicus	65-76
15378015-1	2004	Induced transformation of mouse fibroblasts was carried out by releasing tetracycline-repressed expression of an oncogenic mutant of STAT3, STAT3-C, or of v-Src or Ha-Ras.	tet	73-85	signal transducer and activator of transcription 3	Mus musculus	133-138
15378015-1	2004	Induced transformation of mouse fibroblasts was carried out by releasing tetracycline-repressed expression of an oncogenic mutant of STAT3, STAT3-C, or of v-Src or Ha-Ras.	tet	73-85	signal transducer and activator of transcription 3	Mus musculus	140-145
15378015-1	2004	Induced transformation of mouse fibroblasts was carried out by releasing tetracycline-repressed expression of an oncogenic mutant of STAT3, STAT3-C, or of v-Src or Ha-Ras.	tet	73-85	Harvey rat sarcoma virus oncogene	Mus musculus	164-170
15334659-7	2004	However, the expression of tet-regulated DNRasN17 and adenovirus-encoded DNRasN17 enhanced Stat5 tyrosine phosphorylation, Stat5 DNA binding, and beta-casein transcription.	tet	27-30	signal transducer and activator of transcription 5A	Mus musculus	91-96
15334659-7	2004	However, the expression of tet-regulated DNRasN17 and adenovirus-encoded DNRasN17 enhanced Stat5 tyrosine phosphorylation, Stat5 DNA binding, and beta-casein transcription.	tet	27-30	signal transducer and activator of transcription 5A	Mus musculus	123-128
15334664-3	2004	In the present study, uncoupling protein-3 was expressed in 293 cells using the tetracycline-inducible system and its impact on cell bioenergetics and responsiveness to the apoptotic stimulus was determined.	tet	80-92	uncoupling protein 3	Homo sapiens	22-42
15455033-3	2004	To address this hypothesis, we have used the tetracycline regulatory system to generate transgenic mice in which the expression of a c-MYC human transgene can be conditionally regulated in murine hepatocytes.	tet	45-57	myelocytomatosis oncogene	Mus musculus	135-138
15388428-0	2004	Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital.	tet	152-164	hypothetical protein	Escherichia coli	68-76
15538975-3	2004	After withdrawing tetracycline, the C-JNK fragment expression was induced and cell growth was dramatically inhibited 24 h later.	tet	18-30	mitogen-activated protein kinase 8	Mus musculus	38-41
15386738-2	2004	METHODS: We have combined the streptogramin (PIP)- and tetracycline (TET)-responsive gene regulation systems for independent expression control of the differentiation determinants myoD and msx1 in C2C12-derived cells.	tet	55-67	myogenic differentiation 1	Homo sapiens	180-184
15386738-2	2004	METHODS: We have combined the streptogramin (PIP)- and tetracycline (TET)-responsive gene regulation systems for independent expression control of the differentiation determinants myoD and msx1 in C2C12-derived cells.	tet	55-67	msh homeobox 1	Homo sapiens	189-193
15452200-3	2004	We have addressed this issue in an A6 renal epithelial cell line that expresses SGK1 under the control of a tetracycline-inducible system.	tet	108-120	serum/glucocorticoid regulated kinase 1	Homo sapiens	80-84
15386738-2	2004	METHODS: We have combined the streptogramin (PIP)- and tetracycline (TET)-responsive gene regulation systems for independent expression control of the differentiation determinants myoD and msx1 in C2C12-derived cells.	tet	69-72	myogenic differentiation 1	Homo sapiens	180-184
15386738-2	2004	METHODS: We have combined the streptogramin (PIP)- and tetracycline (TET)-responsive gene regulation systems for independent expression control of the differentiation determinants myoD and msx1 in C2C12-derived cells.	tet	69-72	msh homeobox 1	Homo sapiens	189-193
15556297-5	2004	Ectopic expression of PAPA-1 induced growth suppression of cells, and the effect was dependent on its nucleolar localization in established HeLa cell lines that inducibly express PAPA-1 or its deletion mutant under the control of a tetracycline-inducible promoter.	tet	232-244	INO80 complex subunit B	Homo sapiens	22-28
15146028-11	2004	Specific transport by SMVT was confirmed by oocyte electrophysiology studies and direct uptake studies in human embryonic kidney cells after tetracycline-induced expression of SMVT.	tet	141-153	solute carrier family 5 member 6	Homo sapiens	22-26
15146028-11	2004	Specific transport by SMVT was confirmed by oocyte electrophysiology studies and direct uptake studies in human embryonic kidney cells after tetracycline-induced expression of SMVT.	tet	141-153	solute carrier family 5 member 6	Homo sapiens	176-180
15336560-5	2004	Furthermore, when the expression of transfected beta(2)AR in RAWar cells was down-regulated by a tetracycline repressor-regulated mammalian expression system, expression of IL-12 mRNA and protein following LPS stimulation tended to return to the levels in RAWvec cells.	tet	97-109	adrenoceptor beta 2	Homo sapiens	48-57
15273726-5	2004	Here, we applied the ARF gene as a tumor-suppressive agent for HER2/neu-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	116-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-67
15273726-5	2004	Here, we applied the ARF gene as a tumor-suppressive agent for HER2/neu-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	116-119	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-67
15358420-5	2004	The bla(CTX-M-15) gene was located on two different transferable plasmids, one of which also carried bla(TEM-1), bla(OXA-30), aminoglycoside-, tetracycline-, and sulfamethoxazole-trimethoprim resistance genes.	tet	143-155	beta-lactamase	Escherichia coli	4-7
15358420-5	2004	The bla(CTX-M-15) gene was located on two different transferable plasmids, one of which also carried bla(TEM-1), bla(OXA-30), aminoglycoside-, tetracycline-, and sulfamethoxazole-trimethoprim resistance genes.	tet	143-155	hypothetical protein	Escherichia coli	8-16
15358427-7	2004	These Gram-positive merA genes join Gram-positive tetracycline resistance and Gram-positive macrolide resistance genes in their association with mobile elements which are able to transfer and express in Gram-negative bacteria.	tet	50-62	Mercuric reductase	Staphylococcus aureus	20-24
15364548-1	2004	The degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) and phenobarbital-inducible cytochrome P450 2B1 (CYP2B1) expressed in tetracycline (Tc)-inducible HeLa cell lines was characterized.	tet	136-148	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	37-56
15364548-1	2004	The degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) and phenobarbital-inducible cytochrome P450 2B1 (CYP2B1) expressed in tetracycline (Tc)-inducible HeLa cell lines was characterized.	tet	136-148	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	58-64
15247271-12	2004	In addition, using a tetracycline-inducible Rta BCBL-1 cell line (TREx BCBL1-Rta), JNK was phosphorylated during lytic replication, and inhibition of JNK activation blocked late viral gene expression but not early viral gene expression.	tet	21-33	MAS related GPR family member F	Homo sapiens	44-47
15247271-12	2004	In addition, using a tetracycline-inducible Rta BCBL-1 cell line (TREx BCBL1-Rta), JNK was phosphorylated during lytic replication, and inhibition of JNK activation blocked late viral gene expression but not early viral gene expression.	tet	21-33	MAS related GPR family member F	Homo sapiens	77-80
15247271-12	2004	In addition, using a tetracycline-inducible Rta BCBL-1 cell line (TREx BCBL1-Rta), JNK was phosphorylated during lytic replication, and inhibition of JNK activation blocked late viral gene expression but not early viral gene expression.	tet	21-33	mitogen-activated protein kinase 8	Homo sapiens	83-86
15247271-12	2004	In addition, using a tetracycline-inducible Rta BCBL-1 cell line (TREx BCBL1-Rta), JNK was phosphorylated during lytic replication, and inhibition of JNK activation blocked late viral gene expression but not early viral gene expression.	tet	21-33	mitogen-activated protein kinase 8	Homo sapiens	150-153
15302683-3	2004	We investigated the role of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) on hydrogen peroxide (H(2)O(2))-mediated TRPM2 activation using a tetracycline-inducible TRPM2-expressing cell line.	tet	151-163	Poly-(ADP-ribose) polymerase	Drosophila melanogaster	79-83
15302683-3	2004	We investigated the role of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) on hydrogen peroxide (H(2)O(2))-mediated TRPM2 activation using a tetracycline-inducible TRPM2-expressing cell line.	tet	151-163	transient receptor potential cation channel subfamily M member 2	Homo sapiens	126-131
15302683-3	2004	We investigated the role of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) on hydrogen peroxide (H(2)O(2))-mediated TRPM2 activation using a tetracycline-inducible TRPM2-expressing cell line.	tet	151-163	transient receptor potential cation channel subfamily M member 2	Homo sapiens	174-179
15302683-5	2004	In whole-cell patch-clamp recordings, intracellular adenine 5"-diphosphoribose (ADP-ribose) triggered an inward current in tetracycline-induced TRPM2-human embryonic kidney (HEK293) cells, but not in uninduced cells.	tet	123-135	transient receptor potential cation channel subfamily M member 2	Homo sapiens	144-149
15302683-8	2004	These data demonstrate functional expression of TRPM2 following tetracycline induction in TRPM2-HEK293 cells.	tet	64-76	transient receptor potential cation channel subfamily M member 2	Homo sapiens	48-53
15302683-8	2004	These data demonstrate functional expression of TRPM2 following tetracycline induction in TRPM2-HEK293 cells.	tet	64-76	transient receptor potential cation channel subfamily M member 2	Homo sapiens	90-95
15331531-4	2004	An important finding was that female Syn4 transgenic mice exhibited an increased rate of glucose clearance during glucose tolerance tests that was repressible by the administration of tetracycline.	tet	184-196	syntaxin 4A (placental)	Mus musculus	37-41
15331728-2	2004	To address this question, we have generated a vaccinia virus strain in which expression of the G1L gene is dependent on the addition of tetracycline (TET) when infection proceeds in a cell line expressing the tetracycline repressor.	tet	136-148	putative metalloprotease	Vaccinia virus	95-98
15331728-2	2004	To address this question, we have generated a vaccinia virus strain in which expression of the G1L gene is dependent on the addition of tetracycline (TET) when infection proceeds in a cell line expressing the tetracycline repressor.	tet	150-153	putative metalloprotease	Vaccinia virus	95-98
15331728-2	2004	To address this question, we have generated a vaccinia virus strain in which expression of the G1L gene is dependent on the addition of tetracycline (TET) when infection proceeds in a cell line expressing the tetracycline repressor.	tet	209-221	putative metalloprotease	Vaccinia virus	95-98
15175342-5	2004	Such in vitro interaction was confirmed using cell extracts in which PAIP2 expression is induced by tetracycline (Tet-on cells).	tet	100-112	poly(A) binding protein interacting protein 2	Homo sapiens	69-74
15276240-4	2004	Now, we present evidence that minocycline, a tetracycline derivative, suppresses the hypoxic activation of cultured microglia by inhibiting p38 mitogen-activated protein kinase pathway.	tet	45-57	mitogen-activated protein kinase 14	Homo sapiens	140-143
15208682-3	2004	Here we investigated another main isoform, RASSF1C, and compared it with RASSF1A in the gene inactivation test (GIT), based on a tetracycline regulation system.	tet	129-141	Ras association domain family member 1	Homo sapiens	73-80
15289334-5	2004	We demonstrate here that in EJ human bladder cancer cells containing a tetracycline-regulatable s-HB-EGF or pro-HB-EGF expression system, s-HB-EGF expression increased their transformed phenotypes, including growth rate, colony-forming ability, and activation of cyclin D1 promoter, as well as induction of vascular endothelial growth factor in vitro.	tet	71-83	heparin binding EGF like growth factor	Homo sapiens	98-104
15289334-5	2004	We demonstrate here that in EJ human bladder cancer cells containing a tetracycline-regulatable s-HB-EGF or pro-HB-EGF expression system, s-HB-EGF expression increased their transformed phenotypes, including growth rate, colony-forming ability, and activation of cyclin D1 promoter, as well as induction of vascular endothelial growth factor in vitro.	tet	71-83	cyclin D1	Homo sapiens	263-272
15289334-5	2004	We demonstrate here that in EJ human bladder cancer cells containing a tetracycline-regulatable s-HB-EGF or pro-HB-EGF expression system, s-HB-EGF expression increased their transformed phenotypes, including growth rate, colony-forming ability, and activation of cyclin D1 promoter, as well as induction of vascular endothelial growth factor in vitro.	tet	71-83	vascular endothelial growth factor A	Homo sapiens	307-341
15319038-4	2004	Coinfection of Ad vectors containing the siRNA expression system under the control of the Dox-inducible H1 promoter and Ad vectors expressing a tetracycline repressor inhibited the expression levels of p53 and c-Myc in a dose-dependent manner with both Dox and viral dose.	tet	144-156	tumor protein p53	Homo sapiens	202-205
15319038-4	2004	Coinfection of Ad vectors containing the siRNA expression system under the control of the Dox-inducible H1 promoter and Ad vectors expressing a tetracycline repressor inhibited the expression levels of p53 and c-Myc in a dose-dependent manner with both Dox and viral dose.	tet	144-156	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	210-215
15122072-3	2004	This cytotoxic drug discovery assay is based on a transgenic CHO-K1-derived cell line engineered for a conditional G1-specific growth arrest following tetracycline-responsive overexpression of the human cyclin-dependent kinase inhibitor p27(Kip1).	tet	151-163	zinc ribbon domain containing 2	Homo sapiens	237-240
15122072-3	2004	This cytotoxic drug discovery assay is based on a transgenic CHO-K1-derived cell line engineered for a conditional G1-specific growth arrest following tetracycline-responsive overexpression of the human cyclin-dependent kinase inhibitor p27(Kip1).	tet	151-163	cyclin dependent kinase inhibitor 1B	Homo sapiens	241-245
15122072-6	2004	Addition of chemical or metabolic libraries to CHO-p27(Kip1) populations cultivated in tetracycline-free medium followed by scoring for cell viability will reveal cytotoxic drug candidates associated with a high viability ratio of proliferation-competent/arrested populations.	tet	87-99	zinc ribbon domain containing 2	Homo sapiens	51-54
15122072-6	2004	Addition of chemical or metabolic libraries to CHO-p27(Kip1) populations cultivated in tetracycline-free medium followed by scoring for cell viability will reveal cytotoxic drug candidates associated with a high viability ratio of proliferation-competent/arrested populations.	tet	87-99	cyclin dependent kinase inhibitor 1B	Homo sapiens	55-59
15280497-5	2004	We generated an inducible recombinant in which A13 protein expression is dependent upon the inclusion of tetracycline in the culture medium.	tet	105-117	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	47-50
15177893-4	2004	In this study, induction of LMP1 increased the EGFR in both protein and promoter levels in a dose dependent manner using tetracycline-regulated LMP1 expression in nasopharyngeal carcinoma (NPC) cell line.	tet	121-133	PDZ and LIM domain 7	Homo sapiens	28-32
15294175-0	2004	HLA-A*0201-restricted cytolytic responses to the rtTA transactivator dominant and cryptic epitopes compromise transgene expression induced by the tetracycline on system.	tet	146-158	major histocompatibility complex, class I, A	Homo sapiens	0-5
15250938-0	2004	A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.	tet	77-89	tyrosinase	Mus musculus	40-50
15250938-3	2004	To address the function of tyrosinase in the development of the mammalian visual system, we have generated a transgenic mouse model with inducible expression of the tyrosinase gene using the tetracycline (TET-ON) system.	tet	191-203	tyrosinase	Mus musculus	165-175
15177893-4	2004	In this study, induction of LMP1 increased the EGFR in both protein and promoter levels in a dose dependent manner using tetracycline-regulated LMP1 expression in nasopharyngeal carcinoma (NPC) cell line.	tet	121-133	epidermal growth factor receptor	Homo sapiens	47-51
15177893-4	2004	In this study, induction of LMP1 increased the EGFR in both protein and promoter levels in a dose dependent manner using tetracycline-regulated LMP1 expression in nasopharyngeal carcinoma (NPC) cell line.	tet	121-133	PDZ and LIM domain 7	Homo sapiens	144-148
15249141-0	2004	Rat tyrosine hydroxylase promoter directs tetracycline-inducible foreign gene expression in dopaminergic cell types.	tet	42-54	tyrosine hydroxylase	Rattus norvegicus	4-24
15379256-4	2004	In order to evaluate the function of OprM protein, we measured intracellular tetracycline concentrations with liquid scintillation counter, measured the diameters of bacteriostatic circles with paper disc, and then established a screening model accordingly.	tet	77-89	outer membrane protein OprM	Pseudomonas aeruginosa PAO1	37-41
15087457-8	2004	In addition, the dependence on p53 was confirmed using a second cell type operating a tetracycline-inducible system.	tet	86-98	tumor protein p53	Homo sapiens	31-34
15207910-1	2004	A rat fibroblast cell line was modified to contain the Drosophila choline acetyltransferase (ChAT) cDNA under the control of a tetracycline-regulated system.	tet	127-139	Choline acetyltransferase	Drosophila melanogaster	66-91
15132987-9	2004	With a tetracycline (Tet)-controlled TrkB inducible system, we demonstrated that activation of TrkB in SH-SY5Y cells alleviated 6-OHDA-induced GSK3beta dephosphorylation (Ser9) and ameliorated 6-OHDA neurotoxicity.	tet	7-19	neurotrophic receptor tyrosine kinase 2	Homo sapiens	37-41
15132987-9	2004	With a tetracycline (Tet)-controlled TrkB inducible system, we demonstrated that activation of TrkB in SH-SY5Y cells alleviated 6-OHDA-induced GSK3beta dephosphorylation (Ser9) and ameliorated 6-OHDA neurotoxicity.	tet	7-19	neurotrophic receptor tyrosine kinase 2	Homo sapiens	95-99
15132987-9	2004	With a tetracycline (Tet)-controlled TrkB inducible system, we demonstrated that activation of TrkB in SH-SY5Y cells alleviated 6-OHDA-induced GSK3beta dephosphorylation (Ser9) and ameliorated 6-OHDA neurotoxicity.	tet	7-19	glycogen synthase kinase 3 alpha	Homo sapiens	143-151
15132987-9	2004	With a tetracycline (Tet)-controlled TrkB inducible system, we demonstrated that activation of TrkB in SH-SY5Y cells alleviated 6-OHDA-induced GSK3beta dephosphorylation (Ser9) and ameliorated 6-OHDA neurotoxicity.	tet	21-24	neurotrophic receptor tyrosine kinase 2	Homo sapiens	37-41
15132987-9	2004	With a tetracycline (Tet)-controlled TrkB inducible system, we demonstrated that activation of TrkB in SH-SY5Y cells alleviated 6-OHDA-induced GSK3beta dephosphorylation (Ser9) and ameliorated 6-OHDA neurotoxicity.	tet	21-24	neurotrophic receptor tyrosine kinase 2	Homo sapiens	95-99
15132987-9	2004	With a tetracycline (Tet)-controlled TrkB inducible system, we demonstrated that activation of TrkB in SH-SY5Y cells alleviated 6-OHDA-induced GSK3beta dephosphorylation (Ser9) and ameliorated 6-OHDA neurotoxicity.	tet	21-24	glycogen synthase kinase 3 alpha	Homo sapiens	143-151
15213272-2	2004	The SSAT expression was induced and its enzymatic activity increased 24 h after addition of tetracycline and remained elevated over the length of the experiments.	tet	92-104	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	4-8
15213272-4	2004	SSAT overexpression increased the expression of heme oxygenase-1 (HO-1) by 350% 24 h after addition of tetracycline, indicating the induction of oxidative stress.	tet	103-115	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	0-4
15213272-4	2004	SSAT overexpression increased the expression of heme oxygenase-1 (HO-1) by 350% 24 h after addition of tetracycline, indicating the induction of oxidative stress.	tet	103-115	heme oxygenase 1	Homo sapiens	48-64
15213272-4	2004	SSAT overexpression increased the expression of heme oxygenase-1 (HO-1) by 350% 24 h after addition of tetracycline, indicating the induction of oxidative stress.	tet	103-115	heme oxygenase 1	Homo sapiens	66-70
15246211-0	2004	Reduction and expansion of the glutamine synthetase expressing zone in livers from tetracycline controlled TGF-beta1 transgenic mice and multiple starved mice.	tet	83-95	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	31-51
15246211-0	2004	Reduction and expansion of the glutamine synthetase expressing zone in livers from tetracycline controlled TGF-beta1 transgenic mice and multiple starved mice.	tet	83-95	transforming growth factor, beta 1	Mus musculus	107-116
15246211-1	2004	BACKGROUND/AIMS: To learn more about tissue remodelling in fibrotic livers of tetracycline-controlled TGF-beta1 transgenic mice (TGF-beta1-on-mice) and during regeneration after removal of the fibrotic stimulus (off-mice), we investigated the expression of glutamine synthetase (GS), an exclusive pericentrally expressed enzyme.	tet	78-90	transforming growth factor, beta 1	Mus musculus	102-111
15233949-0	2004	Endogenous GATA factors bind the core sequence of the tetO and influence gene regulation with the tetracycline system.	tet	98-110	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	11-15
15233949-5	2004	The tetracycline operator (tetO) repeats appear to be the source of basal activity and they were shown to harbor motifs for GATA transcription factors.	tet	4-16	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	124-128
15233949-7	2004	The molecular interactions of endogenous and overexpressed GATA factors with the GATA motif in the tetO were demonstrated and effects on function of the tetracycline-regulated gene expression system investigated.	tet	153-165	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	59-63
15233949-7	2004	The molecular interactions of endogenous and overexpressed GATA factors with the GATA motif in the tetO were demonstrated and effects on function of the tetracycline-regulated gene expression system investigated.	tet	153-165	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	81-85
15233949-9	2004	We suggest that endogenous GATA factor expression may influence the degree of gene regulation by the tetracycline system between different cell types.	tet	101-113	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	27-31
15177290-2	2004	To overcome this limitation, the def gene encoding the Escherichia coli peptide deformylase was cloned into the plysS plasmid under the tetracycline (Tc) promoter control.	tet	136-148	peptide deformylase	Escherichia coli	33-36
15177290-2	2004	To overcome this limitation, the def gene encoding the Escherichia coli peptide deformylase was cloned into the plysS plasmid under the tetracycline (Tc) promoter control.	tet	150-152	peptide deformylase	Escherichia coli	33-36
15165753-14	2004	In conclusion, the tetR real-time PCR offers new methods for detection and quantification of tetracycline-resistant bacteria and tTA in transfected cell-lines or transgenic animals.	tet	93-105	tetracycline resistance repressor protein TetR	Escherichia coli	19-23
15096507-4	2004	Thus, SSAT was conditionally overexpressed in LNCaP prostate carcinoma cells via a tetracycline-regulatable (Tet-off) system.	tet	83-95	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	6-10
15096507-5	2004	Tetracycline removal resulted in a rapid approximately 10-fold increase in SSAT mRNA and an increase of approximately 20-fold in enzyme activity.	tet	0-12	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	75-79
15096508-4	2004	In eye-derived cells transfected with a tetracycline turn-on CTCF system, up-regulation of CTCF expression significantly suppressed Pax6 expression.	tet	40-52	CCCTC-binding factor	Mus musculus	61-65
15096508-4	2004	In eye-derived cells transfected with a tetracycline turn-on CTCF system, up-regulation of CTCF expression significantly suppressed Pax6 expression.	tet	40-52	CCCTC-binding factor	Mus musculus	91-95
15096508-4	2004	In eye-derived cells transfected with a tetracycline turn-on CTCF system, up-regulation of CTCF expression significantly suppressed Pax6 expression.	tet	40-52	paired box 6	Mus musculus	132-136
15095297-2	2004	We have established a transgenic mouse model in which c-MYC is conditionally expressed in lymphoid cells using the tetracycline-regulated system of gene regulation.	tet	115-127	myelocytomatosis oncogene	Mus musculus	56-59
15172983-5	2004	Moreover, tetracycline-inducible TAM67 expression in ODC- and ras-transformed cells showed that the transformed phenotype of the cells is reversibly regulatable.	tet	10-22	ornithine decarboxylase, structural 1	Mus musculus	53-56
15177563-7	2004	Consistent with a role in cell cycling, we observe that Chinese hamster ovary cells that express a tetracycline-inducible SNF1LK kinase domain do not divide, but undergo additional rounds of replication to yield 8N and 16N cells.	tet	99-111	salt inducible kinase 1	Homo sapiens	122-128
14990976-5	2004	By varying the concentration of tetracycline in growth media, we found that increasing levels of MLL-AF4 expression result in a progressive decrease in growth rate and fraction of S phase cells, paralleled by an increase in percentage of cells expressing CD11b.	tet	32-44	lysine methyltransferase 2A	Homo sapiens	97-100
14990976-5	2004	By varying the concentration of tetracycline in growth media, we found that increasing levels of MLL-AF4 expression result in a progressive decrease in growth rate and fraction of S phase cells, paralleled by an increase in percentage of cells expressing CD11b.	tet	32-44	AF4/FMR2 family member 1	Homo sapiens	101-104
14990976-5	2004	By varying the concentration of tetracycline in growth media, we found that increasing levels of MLL-AF4 expression result in a progressive decrease in growth rate and fraction of S phase cells, paralleled by an increase in percentage of cells expressing CD11b.	tet	32-44	integrin subunit alpha M	Homo sapiens	255-260
15150092-2	2004	We have developed a tetracycline-based hSNF5/INI1-inducible system in a hSNF5/INI1-deficient malignant rhabdoid tumor cell line and studied time course variation of 22,000 genes/expressed sequence tags upon hSNF5/INI1 induction.	tet	20-32	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	39-44
15150092-2	2004	We have developed a tetracycline-based hSNF5/INI1-inducible system in a hSNF5/INI1-deficient malignant rhabdoid tumor cell line and studied time course variation of 22,000 genes/expressed sequence tags upon hSNF5/INI1 induction.	tet	20-32	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	45-49
15150092-2	2004	We have developed a tetracycline-based hSNF5/INI1-inducible system in a hSNF5/INI1-deficient malignant rhabdoid tumor cell line and studied time course variation of 22,000 genes/expressed sequence tags upon hSNF5/INI1 induction.	tet	20-32	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	72-77
15150092-2	2004	We have developed a tetracycline-based hSNF5/INI1-inducible system in a hSNF5/INI1-deficient malignant rhabdoid tumor cell line and studied time course variation of 22,000 genes/expressed sequence tags upon hSNF5/INI1 induction.	tet	20-32	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	72-77
15150092-2	2004	We have developed a tetracycline-based hSNF5/INI1-inducible system in a hSNF5/INI1-deficient malignant rhabdoid tumor cell line and studied time course variation of 22,000 genes/expressed sequence tags upon hSNF5/INI1 induction.	tet	20-32	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	78-82
15094388-0	2004	In vivo transgene expression using an adenoviral tetracycline-regulated system with neuron-specific enolase promoter.	tet	49-61	enolase 2	Rattus norvegicus	84-107
15094388-1	2004	A recombinant adenoviral tetracycline-regulated system with neuron-specific enolase (NSE) promoter was injected stereotaxically into the striatum of rat brains.	tet	25-37	enolase 2	Rattus norvegicus	60-83
15094388-1	2004	A recombinant adenoviral tetracycline-regulated system with neuron-specific enolase (NSE) promoter was injected stereotaxically into the striatum of rat brains.	tet	25-37	enolase 2	Rattus norvegicus	85-88
15094388-4	2004	These results indicate that tetracycline-inhibitable transcription factor (tTA) can drive tetracycline-responsive promoter (TetOp) under the control of NSE promoter, thereby efficiently and selectively expressing gammaPKC-GFP in neurons in vivo.	tet	28-40	enolase 2	Rattus norvegicus	152-155
15094388-4	2004	These results indicate that tetracycline-inhibitable transcription factor (tTA) can drive tetracycline-responsive promoter (TetOp) under the control of NSE promoter, thereby efficiently and selectively expressing gammaPKC-GFP in neurons in vivo.	tet	90-102	enolase 2	Rattus norvegicus	152-155
15080908-0	2004	Study of the interactions between tetracycline analogues and lysozyme.	tet	34-46	lysozyme	Homo sapiens	61-69
15080908-1	2004	The interactions between tetracycline analogues (oxytetracycline, doxycycline, methacycline) and lysozyme (LYSO) were studied by using UV-visible absorption and spectrofluorimetric method.	tet	25-37	lysozyme	Homo sapiens	97-105
15080908-1	2004	The interactions between tetracycline analogues (oxytetracycline, doxycycline, methacycline) and lysozyme (LYSO) were studied by using UV-visible absorption and spectrofluorimetric method.	tet	25-37	lysozyme	Homo sapiens	107-111
15080908-2	2004	Tetracycline analogues can make LYSO"s fluorescence quenching.	tet	0-12	lysozyme	Homo sapiens	32-36
15080908-5	2004	The binding constants of tetracycline analogues with LYSO were obtained at various temperatures.	tet	25-37	lysozyme	Homo sapiens	53-57
15138177-4	2004	We established a series of stable cell lines expressing three mutant forms of vav1 in a tetracycline-regulatable fashion: (i) a form producing a truncated protein, vavC; (ii) a form containing a point mutation in the regulatory tyrosine residue, vavYF174; and (iii) a form with an in-frame deletion of 6 amino acids required for the guanidine nucleotide exchange factor (GEF) activity of vav1 for rac family GTPases, vavGEFmt.	tet	88-100	vav 1 oncogene	Mus musculus	78-82
15090494-12	2004	Mutations that abolished base pairing in the stem that formed the base of this putative hairpin structure made GUS production as high in the absence of TET as in TET-stimulated cells.	tet	162-165	glucuronidase beta	Homo sapiens	111-114
15585109-1	2004	In this study, a tetracycline-regulated lentiviral vector system, based on the tetracycline-dependent transactivator rtTA2(S)-M2, was developed for controlled expression of glial cell line-derived neurotrophic factor (GDNF) in the rat brain.	tet	17-29	glial cell derived neurotrophic factor	Rattus norvegicus	173-216
15585109-1	2004	In this study, a tetracycline-regulated lentiviral vector system, based on the tetracycline-dependent transactivator rtTA2(S)-M2, was developed for controlled expression of glial cell line-derived neurotrophic factor (GDNF) in the rat brain.	tet	17-29	glial cell derived neurotrophic factor	Rattus norvegicus	218-222
15585109-1	2004	In this study, a tetracycline-regulated lentiviral vector system, based on the tetracycline-dependent transactivator rtTA2(S)-M2, was developed for controlled expression of glial cell line-derived neurotrophic factor (GDNF) in the rat brain.	tet	79-91	glial cell derived neurotrophic factor	Rattus norvegicus	173-216
15585109-1	2004	In this study, a tetracycline-regulated lentiviral vector system, based on the tetracycline-dependent transactivator rtTA2(S)-M2, was developed for controlled expression of glial cell line-derived neurotrophic factor (GDNF) in the rat brain.	tet	79-91	glial cell derived neurotrophic factor	Rattus norvegicus	218-222
15585109-5	2004	The level of basal expression was markedly reduced when a 10-fold lower dose of the tetracycline-regulated GDNF vector was injected into the striatum (3-11 pg/mg tissue), and doxycycline-induced GDNF tissue levels obtained in these animals were about 190 pg/mg tissue.	tet	84-96	glial cell derived neurotrophic factor	Rattus norvegicus	107-111
15585109-5	2004	The level of basal expression was markedly reduced when a 10-fold lower dose of the tetracycline-regulated GDNF vector was injected into the striatum (3-11 pg/mg tissue), and doxycycline-induced GDNF tissue levels obtained in these animals were about 190 pg/mg tissue.	tet	84-96	glial cell derived neurotrophic factor	Rattus norvegicus	195-199
15176089-5	2004	We generated two independent strains of nestin-tTA transgenic animals and crossed founder mice from both lines to mice containing a tetracycline-regulated transgene (mCREB) whose expression served as a marker for the activity of the nestin-tTA transgene.	tet	132-144	cAMP responsive element binding protein 1	Mus musculus	166-171
15115657-4	2004	In this study, induction of LMP1 increased the EGFR in both protein and promoter levels in a dose-dependent manner using tetracycline-regulated LMP1 expression in nasopharyngeal carcinoma (NPC) cell line.	tet	121-133	PDZ and LIM domain 7	Homo sapiens	28-32
15115657-4	2004	In this study, induction of LMP1 increased the EGFR in both protein and promoter levels in a dose-dependent manner using tetracycline-regulated LMP1 expression in nasopharyngeal carcinoma (NPC) cell line.	tet	121-133	epidermal growth factor receptor	Homo sapiens	47-51
15115657-4	2004	In this study, induction of LMP1 increased the EGFR in both protein and promoter levels in a dose-dependent manner using tetracycline-regulated LMP1 expression in nasopharyngeal carcinoma (NPC) cell line.	tet	121-133	PDZ and LIM domain 7	Homo sapiens	144-148
15332324-3	2004	Expression of p57KIP2 was induced in U373 and U87 malignant glioma cells with doxycycline using the tetracycline repressor system.	tet	100-112	cyclin dependent kinase inhibitor 1C	Homo sapiens	14-21
15226432-5	2004	Indeed, tetracycline-inducible expression experiments revealed that both of these IRF proteins up-regulated IL-7 protein production, and their exclusive roles were further confirmed by small interfering RNA-mediated gene silencing systems.	tet	8-20	interleukin 7	Homo sapiens	108-112
15162378-5	2004	Tetracycline-regulated Bcl-xL expression system and dominant negative STAT3 transfectants were used to study IL-6 signaling pathways and its anti-apoptosis effects.	tet	0-12	BCL2 like 1	Homo sapiens	23-29
15215867-3	2004	Here we have used a tetracycline-regulated Blm allele (Blm(tet)) to introduce bi-allelic mutations across the genome in mouse embryonic stem (ES) cells.	tet	20-32	Bloom syndrome, RecQ like helicase	Mus musculus	43-46
15215867-3	2004	Here we have used a tetracycline-regulated Blm allele (Blm(tet)) to introduce bi-allelic mutations across the genome in mouse embryonic stem (ES) cells.	tet	20-32	Bloom syndrome, RecQ like helicase	Mus musculus	55-58
15205323-0	2004	Control of radiosensitivity of F9 mouse teratocarcinoma cells by regulation of histone H2AX gene expression using a tetracycline turn-off system.	tet	116-128	H2A.X variant histone	Mus musculus	79-91
15205323-4	2004	In homozygously recombined cells, expression of the histone H2AX gene was repressed to 0.02% of the expression observed in wild-type cells by the addition of doxycycline, an analog of tet.	tet	184-187	H2A.X variant histone	Mus musculus	52-64
15205323-6	2004	When we s.c. injected tet-regulated F9 cells into the flanks of mice, tumor growth was slightly suppressed by X-irradiation in H2AX-repressed tumors, whereas without X-irradiation, tumor growth did not differ by H2AX status.	tet	22-25	H2A.X variant histone	Mus musculus	127-131
15205324-5	2004	We also developed a tetracycline-inducible cell line model to study the cellular consequences of HNF3 beta expression.	tet	20-32	forkhead box A2	Homo sapiens	97-106
15163513-5	2004	Trans-acting genes cre and large T antigen, which were under the control of a tetracycline responsive promoter, were also inserted into the 5"- and 3"-UTRs of the iNOS, respectively, by homologous recombination.	tet	78-90	inositol-3-phosphate synthase 1	Homo sapiens	163-167
15147370-3	2004	To assess the functions of E2A-HLF and E4BP4 in cell survival, a tetracycline-inducible system was established in Baf-3 cells to express E4BP4 or E2A-HLF.	tet	65-77	nuclear factor, interleukin 3, regulated	Mus musculus	137-142
15194129-8	2004	Linezolid was active against all the isolates tested and tetracycline resistance was the major one in VGS (41.6%) and Gemella spp.	tet	57-69	histocompatibility minor 13	Homo sapiens	126-129
15095291-5	2004	A fibroblast cell line was established in which MKP-3 expression is controlled by tetracycline.	tet	82-94	dual specificity phosphatase 6	Mus musculus	48-53
15095291-6	2004	Tetracycline-induced MKP-3 resulted in partial de-phosphorylation of p42/p44 MAPKs in serum-stimulated cells.	tet	0-12	dual specificity phosphatase 6	Mus musculus	21-26
15095291-6	2004	Tetracycline-induced MKP-3 resulted in partial de-phosphorylation of p42/p44 MAPKs in serum-stimulated cells.	tet	0-12	cyclin-dependent kinase 20	Mus musculus	69-72
15095291-6	2004	Tetracycline-induced MKP-3 resulted in partial de-phosphorylation of p42/p44 MAPKs in serum-stimulated cells.	tet	0-12	mitogen-activated protein kinase 3	Mus musculus	73-76
15095291-11	2004	Treatment of mice with the tetracycline analog doxycycline resulted in a large delay in tumor emergence and growth as compared to the untreated control group, indicating that MKP-3-GFP activity is maintained in vivo.	tet	27-39	dual specificity phosphatase 6	Mus musculus	175-180
15140973-1	2004	By selectively regulating the expression of the trans-dominant-negative mutant polypeptide UL9-C535C, of herpes simplex virus type 1 (HSV-1) origin binding protein UL9 with the tetracycline repressor (tetR)-mediated gene switch, we recently generated a novel replication-defective and anti-HSV-specific HSV-1 recombinant, CJ83193.	tet	177-189	DNA replication origin-binding helicase	Human alphaherpesvirus 1	91-94
15140973-1	2004	By selectively regulating the expression of the trans-dominant-negative mutant polypeptide UL9-C535C, of herpes simplex virus type 1 (HSV-1) origin binding protein UL9 with the tetracycline repressor (tetR)-mediated gene switch, we recently generated a novel replication-defective and anti-HSV-specific HSV-1 recombinant, CJ83193.	tet	177-189	DNA replication origin-binding helicase	Human alphaherpesvirus 1	164-167
15047868-6	2004	Using the tetracycline-controlled system (tet-off), we observed that overexpression of this 112-residue CPAP inhibits cell proliferation and induces apoptosis after G2/M arrest.	tet	10-22	centromere protein J	Homo sapiens	104-108
14990579-7	2004	Tetracycline-regulated IFI16 also induced apoptosis when coexpressed with p53 in p53-deficient EJ cells subjected to IR, suggesting that IFI16 is involved in p53-mediated transmission of apoptosis signaling.	tet	0-12	interferon gamma inducible protein 16	Homo sapiens	23-28
14990579-7	2004	Tetracycline-regulated IFI16 also induced apoptosis when coexpressed with p53 in p53-deficient EJ cells subjected to IR, suggesting that IFI16 is involved in p53-mediated transmission of apoptosis signaling.	tet	0-12	tumor protein p53	Homo sapiens	74-77
14990579-7	2004	Tetracycline-regulated IFI16 also induced apoptosis when coexpressed with p53 in p53-deficient EJ cells subjected to IR, suggesting that IFI16 is involved in p53-mediated transmission of apoptosis signaling.	tet	0-12	tumor protein p53	Homo sapiens	81-84
14990579-7	2004	Tetracycline-regulated IFI16 also induced apoptosis when coexpressed with p53 in p53-deficient EJ cells subjected to IR, suggesting that IFI16 is involved in p53-mediated transmission of apoptosis signaling.	tet	0-12	interferon gamma inducible protein 16	Homo sapiens	137-142
14990579-7	2004	Tetracycline-regulated IFI16 also induced apoptosis when coexpressed with p53 in p53-deficient EJ cells subjected to IR, suggesting that IFI16 is involved in p53-mediated transmission of apoptosis signaling.	tet	0-12	tumor protein p53	Homo sapiens	81-84
15111320-6	2004	The Ishikawa cell line, with stable or tetracycline-regulated expression of mutant beta-catenin, showed an increase in expression levels of cyclin D1, p14ARF, p53, and p21WAF1 but not PML, and activation of beta-catenin-TCF4-mediated transcription determined with TOP/FOP constructs.	tet	39-51	catenin beta 1	Homo sapiens	83-95
15111320-6	2004	The Ishikawa cell line, with stable or tetracycline-regulated expression of mutant beta-catenin, showed an increase in expression levels of cyclin D1, p14ARF, p53, and p21WAF1 but not PML, and activation of beta-catenin-TCF4-mediated transcription determined with TOP/FOP constructs.	tet	39-51	cyclin D1	Homo sapiens	140-149
15111320-6	2004	The Ishikawa cell line, with stable or tetracycline-regulated expression of mutant beta-catenin, showed an increase in expression levels of cyclin D1, p14ARF, p53, and p21WAF1 but not PML, and activation of beta-catenin-TCF4-mediated transcription determined with TOP/FOP constructs.	tet	39-51	cyclin dependent kinase inhibitor 2A	Homo sapiens	151-157
15111320-6	2004	The Ishikawa cell line, with stable or tetracycline-regulated expression of mutant beta-catenin, showed an increase in expression levels of cyclin D1, p14ARF, p53, and p21WAF1 but not PML, and activation of beta-catenin-TCF4-mediated transcription determined with TOP/FOP constructs.	tet	39-51	tumor protein p53	Homo sapiens	159-162
15111320-6	2004	The Ishikawa cell line, with stable or tetracycline-regulated expression of mutant beta-catenin, showed an increase in expression levels of cyclin D1, p14ARF, p53, and p21WAF1 but not PML, and activation of beta-catenin-TCF4-mediated transcription determined with TOP/FOP constructs.	tet	39-51	catenin beta 1	Homo sapiens	207-219
15111320-6	2004	The Ishikawa cell line, with stable or tetracycline-regulated expression of mutant beta-catenin, showed an increase in expression levels of cyclin D1, p14ARF, p53, and p21WAF1 but not PML, and activation of beta-catenin-TCF4-mediated transcription determined with TOP/FOP constructs.	tet	39-51	transcription factor 4	Homo sapiens	220-224
15249141-6	2004	Moreover, the TH promoter could be combined with the bi-directional Tet response system, BiTetO, allowing for the co-expression and regulation of two genes in the same cell.	tet	68-71	tyrosine hydroxylase	Rattus norvegicus	14-16
15099589-2	2004	Using a modified patch-clamp technique in combination with an ultrafast system for solution exchange we investigated the functional interaction of gentamicin, penicillin G, tetracycline, erythromycin and ceftriaxone with nAChR transiently transfected into HEK293 cells as a potential molecular target.	tet	173-185	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	221-226
15099589-3	2004	Gentamicin, penicillin G, tetracycline and erythromycin induced a combination of open channel and competitive block of nAChR channel currents whereas ceftriaxone had no effect.	tet	26-38	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	119-124
15193235-1	2004	AIM: To construct Tetracycline(tet) inducible recombinant adenovirus vectors containing human neurotrophin 3(NT3) and brain-derived neurotrophic factor(BDNF) genes, respectively and perform PCR and restrictive enzyme digestion analysis.	tet	18-30	neurotrophin 3	Homo sapiens	94-108
15161370-3	2004	Using a tetracycline-repressible system, we found that removal of tetracycline for 16 h induced Bcl-X(S) and reduced the surviving fraction of NIH 3T3 cells to 25%.	tet	8-20	BCL2-like 1	Mus musculus	96-101
15161370-3	2004	Using a tetracycline-repressible system, we found that removal of tetracycline for 16 h induced Bcl-X(S) and reduced the surviving fraction of NIH 3T3 cells to 25%.	tet	66-78	BCL2-like 1	Mus musculus	96-101
15112343-4	2004	METHODS: BNIPL-2 was overexpressed in Hep3B cells using tetracycline inducible or Tet-on system.	tet	56-68	BCL2 interacting protein like	Homo sapiens	9-16
15193235-1	2004	AIM: To construct Tetracycline(tet) inducible recombinant adenovirus vectors containing human neurotrophin 3(NT3) and brain-derived neurotrophic factor(BDNF) genes, respectively and perform PCR and restrictive enzyme digestion analysis.	tet	18-30	3'-nucleotidase	Homo sapiens	109-112
15193235-1	2004	AIM: To construct Tetracycline(tet) inducible recombinant adenovirus vectors containing human neurotrophin 3(NT3) and brain-derived neurotrophic factor(BDNF) genes, respectively and perform PCR and restrictive enzyme digestion analysis.	tet	18-30	brain derived neurotrophic factor	Homo sapiens	118-151
15060629-0	2004	Re-expression of estrogen receptor alpha using a tetracycline-regulated gene expression system induced estrogen-mediated growth inhibition of the MDA-MB-231 breast cancer cell line.	tet	49-61	estrogen receptor 1	Homo sapiens	17-40
15060629-3	2004	We have transfected the human wild-type ER alpha to an ER-negative breast cancer cell line (MDA-MB-231) using a tetracycline-regulated gene expression system.	tet	112-124	estrogen receptor 1	Homo sapiens	40-48
15059906-9	2004	Tetracycline treatment of RII transfectants led to the suppression of p21/waf1/cip1and p27/kip expression, thus, directly demonstrating induction of CDK inhibitors by autocrine TGF-beta leading to growth control of ER(+) breast cancer cells.	tet	0-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-83
15059906-9	2004	Tetracycline treatment of RII transfectants led to the suppression of p21/waf1/cip1and p27/kip expression, thus, directly demonstrating induction of CDK inhibitors by autocrine TGF-beta leading to growth control of ER(+) breast cancer cells.	tet	0-12	dynactin subunit 6	Homo sapiens	87-90
15059906-9	2004	Tetracycline treatment of RII transfectants led to the suppression of p21/waf1/cip1and p27/kip expression, thus, directly demonstrating induction of CDK inhibitors by autocrine TGF-beta leading to growth control of ER(+) breast cancer cells.	tet	0-12	transforming growth factor beta 1	Homo sapiens	177-185
15047616-2	2004	For directly testing the model, INSr3 cell clones overexpressing malonyl-CoA decarboxylase in the cytosol (MCDc) in a tetracycline regulatable manner were generated, and INS(832/13) and rat islets were infected with MCDc-expressing adenoviruses.	tet	118-130	malonyl-CoA decarboxylase	Rattus norvegicus	65-90
15059885-4	2004	A 3-fold increase in the MnSOD promoter activity was observed after the induction of p53 in Li-Fraumeni syndrome (LFS) fibroblast, TR9-7, expressing p53 under the control of a tetracycline-regulated promoter.	tet	176-188	superoxide dismutase 2	Homo sapiens	25-30
15115618-3	2004	By using RevTet-On TRAIL gene expression system in Jurkat as a cell model, we studied the influence of TRAIL gene on the changes of cellular apoptosis before and after the TRAIL gene expression, which was induced by adding tetracycline derivative doxycycline (Dox).	tet	223-235	TNF superfamily member 10	Homo sapiens	103-108
15115618-3	2004	By using RevTet-On TRAIL gene expression system in Jurkat as a cell model, we studied the influence of TRAIL gene on the changes of cellular apoptosis before and after the TRAIL gene expression, which was induced by adding tetracycline derivative doxycycline (Dox).	tet	223-235	TNF superfamily member 10	Homo sapiens	103-108
15124117-6	2004	The review examines also several ways of obtaining overexpression of utrophin in adult mdx mice, such as conditioned expression of the utrophin transgene (using a tetracycline-sensitive transactivator), transfection with viral vectors containing the utrophin cDNA (complete or truncated), actions on factor(s) controlling utrophin expression at the neuromuscular junction (heregulin, 4 N-acetylgalactosamine), and pharmacological ways of inducing expression (NO, arginine).	tet	163-175	utrophin	Mus musculus	69-77
15090494-10	2004	Moreover, reverse transcription-PCR amplification of tetQ mRNA revealed that despite the fact that the uidA gene product, beta-glucuronidase (GUS), was produced only when the cells were exposed to TET, tetQ mRNA was produced in both the presence and absence of TET.	tet	197-200	glucuronidase beta	Homo sapiens	122-140
15090494-10	2004	Moreover, reverse transcription-PCR amplification of tetQ mRNA revealed that despite the fact that the uidA gene product, beta-glucuronidase (GUS), was produced only when the cells were exposed to TET, tetQ mRNA was produced in both the presence and absence of TET.	tet	197-200	glucuronidase beta	Homo sapiens	142-145
15090494-10	2004	Moreover, reverse transcription-PCR amplification of tetQ mRNA revealed that despite the fact that the uidA gene product, beta-glucuronidase (GUS), was produced only when the cells were exposed to TET, tetQ mRNA was produced in both the presence and absence of TET.	tet	261-264	glucuronidase beta	Homo sapiens	122-140
15090494-10	2004	Moreover, reverse transcription-PCR amplification of tetQ mRNA revealed that despite the fact that the uidA gene product, beta-glucuronidase (GUS), was produced only when the cells were exposed to TET, tetQ mRNA was produced in both the presence and absence of TET.	tet	261-264	glucuronidase beta	Homo sapiens	142-145
15093189-5	2004	We have therefore constructed a dual-construct vector for the recombinant AAV (rAAV)-based recombinant human BMP-2 (rhBMP-2) gene delivery system, which is regulated by the tetracycline-sensitive promoter (TetON).	tet	173-185	bone morphogenetic protein 2	Homo sapiens	109-114
14726688-3	2004	In order to analyze the functional relevance of Bcl-X(S) in AML, Bcl-X(S) was moderately (2-3 fold) overexpressed in the AML cell lines HL-60 and MO7e by transfection with a tetracycline-regulatable Bcl-X(S) expression system.	tet	174-186	BCL2 like 1	Homo sapiens	65-70
12936910-6	2004	To confirm the role of p21 in G(1) arrest, we created H1299 cells with tetracycline-inducible expression of enhanced green fluorescent protein (EGFP), EGFP fused to p21 (EGFp21), or EGFP fused to p27 (EGFp27), a related cell cycle inhibitor.	tet	71-83	cyclin dependent kinase inhibitor 1A	Homo sapiens	23-26
12936910-6	2004	To confirm the role of p21 in G(1) arrest, we created H1299 cells with tetracycline-inducible expression of enhanced green fluorescent protein (EGFP), EGFP fused to p21 (EGFp21), or EGFP fused to p27 (EGFp27), a related cell cycle inhibitor.	tet	71-83	cyclin dependent kinase inhibitor 1A	Homo sapiens	165-168
12936910-6	2004	To confirm the role of p21 in G(1) arrest, we created H1299 cells with tetracycline-inducible expression of enhanced green fluorescent protein (EGFP), EGFP fused to p21 (EGFp21), or EGFP fused to p27 (EGFp27), a related cell cycle inhibitor.	tet	71-83	interferon alpha inducible protein 27	Homo sapiens	196-199
14726688-3	2004	In order to analyze the functional relevance of Bcl-X(S) in AML, Bcl-X(S) was moderately (2-3 fold) overexpressed in the AML cell lines HL-60 and MO7e by transfection with a tetracycline-regulatable Bcl-X(S) expression system.	tet	174-186	BCL2 like 1	Homo sapiens	65-70
14712293-3	2004	Here, we describe the establishment and phenotypic characterization of U937 cells in which P210 BCR/ABL can be conditionally expressed using tetracycline.	tet	141-153	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	96-103
15066158-5	2004	In addition, a regulatable lentivirus was developed bearing the rat CD81 gene under the control of a tetracycline inducible system.	tet	101-113	Cd81 molecule	Rattus norvegicus	68-72
15088876-9	2004	Conditioning of diseased cementum with tetracycline before extraction resulted in augmented levels of TNF-alpha and IFN-gamma, and reduced levels of IL-10, compared with untreated diseased cementum.	tet	39-51	tumor necrosis factor	Mus musculus	102-111
15088876-9	2004	Conditioning of diseased cementum with tetracycline before extraction resulted in augmented levels of TNF-alpha and IFN-gamma, and reduced levels of IL-10, compared with untreated diseased cementum.	tet	39-51	interferon gamma	Mus musculus	116-125
15088876-9	2004	Conditioning of diseased cementum with tetracycline before extraction resulted in augmented levels of TNF-alpha and IFN-gamma, and reduced levels of IL-10, compared with untreated diseased cementum.	tet	39-51	interleukin 10	Mus musculus	149-154
15098205-5	2004	Under the optimum conditions, the calibration curve is linear over the range 3.75 x 10(-8) g/mL-1.5 x 10(-5) g/mL for tetracycline with the linear equation: deltaINT = 205.898 x C - 20.442 (R2 = 0.9974).	tet	118-130	skull morphology 22	Mus musculus	93-99
15005341-3	2004	Treatment of these cells with doxycycline, a tetracycline analogue, rapidly induced expression of the TEL/ARG protein.	tet	45-57	ets variant 6	Mus musculus	102-105
14699072-3	2004	We prepared human U2OS osteosarcoma cells that are stably transfected with a tetracycline-inducible vector to express ERalpha or ERbeta.	tet	77-89	estrogen receptor 1	Homo sapiens	118-125
14699072-3	2004	We prepared human U2OS osteosarcoma cells that are stably transfected with a tetracycline-inducible vector to express ERalpha or ERbeta.	tet	77-89	estrogen receptor 2	Homo sapiens	129-135
14687223-2	2004	BACKGROUND: Tetracycline can significantly inhibit MMP activity in GCF and in gingival tissue, even in much lower dosage then a traditional antimicrobial dosage used in conventional therapy.	tet	12-24	matrix metallopeptidase 8	Homo sapiens	51-54
14742663-4	2004	We used a transcriptional pulse strategy relying on a tetracycline-regulated promoter to study the decay of a PTC- containing beta-globin mRNA in human cells.	tet	54-66	hemoglobin subunit beta	Homo sapiens	126-137
14712213-2	2004	To study DBCCR1 function, stable cell lines, inducible for DBCCR1 expression by tetracycline, were made, but the DBCCR1 protein was not expressed at detectable levels.	tet	80-92	BMP/retinoic acid inducible neural specific 1	Homo sapiens	59-65
14712213-2	2004	To study DBCCR1 function, stable cell lines, inducible for DBCCR1 expression by tetracycline, were made, but the DBCCR1 protein was not expressed at detectable levels.	tet	80-92	BMP/retinoic acid inducible neural specific 1	Homo sapiens	59-65
14704358-4	2004	We have engineered C2C12 cells for dual-regulated expression of human C/EBP-alpha and BMP-2 to enable independent transcription control of both differentiation factors using clinically licensed antibiotics of the streptogramin (pristinamycin) and tetracycline (tetracycline) classes.	tet	261-273	CCAAT enhancer binding protein alpha	Homo sapiens	70-81
14704358-4	2004	We have engineered C2C12 cells for dual-regulated expression of human C/EBP-alpha and BMP-2 to enable independent transcription control of both differentiation factors using clinically licensed antibiotics of the streptogramin (pristinamycin) and tetracycline (tetracycline) classes.	tet	247-259	CCAAT enhancer binding protein alpha	Homo sapiens	70-81
14704358-4	2004	We have engineered C2C12 cells for dual-regulated expression of human C/EBP-alpha and BMP-2 to enable independent transcription control of both differentiation factors using clinically licensed antibiotics of the streptogramin (pristinamycin) and tetracycline (tetracycline) classes.	tet	247-259	bone morphogenetic protein 2	Homo sapiens	86-91
14729627-3	2004	To determine whether HER-2/neu influences the MHC class I antigen-processing pathway, the expression pattern of different APM components was examined in murine in vitro models of constitutive and tetracycline-controlled HER-2/neu expression.	tet	196-208	erb-b2 receptor tyrosine kinase 2	Mus musculus	220-229
15612667-2	2004	The present study was designed to generate a recombinant adenovirus containing the tetracycline (Tet)-regulated endothelial nitric oxide synthase (eNOS) gene and to detect the controllable expression of the gene in esophageal smooth muscle cells (ESMC).	tet	83-95	nitric oxide synthase 3	Homo sapiens	112-145
15612667-2	2004	The present study was designed to generate a recombinant adenovirus containing the tetracycline (Tet)-regulated endothelial nitric oxide synthase (eNOS) gene and to detect the controllable expression of the gene in esophageal smooth muscle cells (ESMC).	tet	83-95	nitric oxide synthase 3	Homo sapiens	147-151
15612667-2	2004	The present study was designed to generate a recombinant adenovirus containing the tetracycline (Tet)-regulated endothelial nitric oxide synthase (eNOS) gene and to detect the controllable expression of the gene in esophageal smooth muscle cells (ESMC).	tet	97-100	nitric oxide synthase 3	Homo sapiens	112-145
15612667-2	2004	The present study was designed to generate a recombinant adenovirus containing the tetracycline (Tet)-regulated endothelial nitric oxide synthase (eNOS) gene and to detect the controllable expression of the gene in esophageal smooth muscle cells (ESMC).	tet	97-100	nitric oxide synthase 3	Homo sapiens	147-151
15612667-8	2004	CONCLUSIONS: A Tet- (or Dox-) regulated recombinant adenovirus carrying eNOS was successfully generated and controllable expression of eNOS in ESMC was achieved, which provides some material for conducting further gene therapy studies with eNOS.	tet	15-18	nitric oxide synthase 3	Homo sapiens	72-76
15612667-8	2004	CONCLUSIONS: A Tet- (or Dox-) regulated recombinant adenovirus carrying eNOS was successfully generated and controllable expression of eNOS in ESMC was achieved, which provides some material for conducting further gene therapy studies with eNOS.	tet	15-18	nitric oxide synthase 3	Homo sapiens	135-139
15612667-8	2004	CONCLUSIONS: A Tet- (or Dox-) regulated recombinant adenovirus carrying eNOS was successfully generated and controllable expression of eNOS in ESMC was achieved, which provides some material for conducting further gene therapy studies with eNOS.	tet	15-18	nitric oxide synthase 3	Homo sapiens	135-139
14718389-2	2004	A tetracycline-inducible ERalpha overexpression model was developed in the MCF-7 cell line to assess induction of endogenous gene activation and growth in response to elevations in ERalpha protein.	tet	2-14	estrogen receptor 1	Homo sapiens	25-32
14718389-2	2004	A tetracycline-inducible ERalpha overexpression model was developed in the MCF-7 cell line to assess induction of endogenous gene activation and growth in response to elevations in ERalpha protein.	tet	2-14	estrogen receptor 1	Homo sapiens	181-188
14734818-0	2004	Establishment of stable melanoma cell line expressing a novel gene, jpk, using a tetracycline-controlled gene expression system.	tet	81-93	aquaporin 2	Mus musculus	68-71
14734818-3	2004	Because Jpk reduces the viability of B16F10 cells when transiently expressed, the Jpk gene was cloned into a tetracycline-controlled gene expression vector, pRetro-On to circumvent the lethal effect in unwanted situations.	tet	109-121	aquaporin 2	Mus musculus	82-85
14734818-5	2004	Out of a total of 53 stable clones selected with puromycin, two clones overexpressed Jpk at more than twice the level when induced by doxycycline, a tetracycline-derivative, which implies the amount of the Jpk exhibiting the toxicity is critical.	tet	149-161	aquaporin 2	Mus musculus	85-88
14734818-5	2004	Out of a total of 53 stable clones selected with puromycin, two clones overexpressed Jpk at more than twice the level when induced by doxycycline, a tetracycline-derivative, which implies the amount of the Jpk exhibiting the toxicity is critical.	tet	149-161	aquaporin 2	Mus musculus	206-209
15099679-0	2004	Perinuclear biogenesis of mutant torsin-A inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors.	tet	85-97	torsin family 1 member A	Homo sapiens	33-41
15099679-4	2004	In this study we examined the biogenesis of mutant torsinA-positive membrane inclusions using tetracycline-regulated herpes simplex virus amplicon vectors.	tet	94-106	torsin family 1 member A	Homo sapiens	51-58
14990861-2	2004	Previous studies using a tetracycline-regulated Oct-4 transgene in the ZHBTc4 cell line demonstrated that downregulation of Oct-4 expression induced dedifferentiation into trophoblast, a lineage mouse ES cells do not normally generate.	tet	25-37	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	48-53
14990861-2	2004	Previous studies using a tetracycline-regulated Oct-4 transgene in the ZHBTc4 cell line demonstrated that downregulation of Oct-4 expression induced dedifferentiation into trophoblast, a lineage mouse ES cells do not normally generate.	tet	25-37	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	124-129
14704358-4	2004	We have engineered C2C12 cells for dual-regulated expression of human C/EBP-alpha and BMP-2 to enable independent transcription control of both differentiation factors using clinically licensed antibiotics of the streptogramin (pristinamycin) and tetracycline (tetracycline) classes.	tet	261-273	bone morphogenetic protein 2	Homo sapiens	86-91
14668794-4	2003	Overexpression of CD95 in a tetracycline-inducible expression system enhanced melanoma cell sensitivity to CD95 ligation but was unable to trigger apoptosis by itself.	tet	28-40	Fas cell surface death receptor	Homo sapiens	18-22
14668794-4	2003	Overexpression of CD95 in a tetracycline-inducible expression system enhanced melanoma cell sensitivity to CD95 ligation but was unable to trigger apoptosis by itself.	tet	28-40	Fas cell surface death receptor	Homo sapiens	107-111
14654789-7	2003	Furthermore, tetracycline-induced IFI16 collaborated in inducing apoptosis when adenovirus p53 was expressed in DNA-damaged p53-deficient EJ cells.	tet	13-25	interferon activated gene 204	Mus musculus	34-39
14654789-7	2003	Furthermore, tetracycline-induced IFI16 collaborated in inducing apoptosis when adenovirus p53 was expressed in DNA-damaged p53-deficient EJ cells.	tet	13-25	transformation related protein 53, pseudogene	Mus musculus	91-94
14654789-7	2003	Furthermore, tetracycline-induced IFI16 collaborated in inducing apoptosis when adenovirus p53 was expressed in DNA-damaged p53-deficient EJ cells.	tet	13-25	transformation related protein 53, pseudogene	Mus musculus	124-127
14627433-2	2003	Using cells stably transfected with inducible NO synthase (iNOS) under the control of a tetracycline-inducible promoter, they generated a range of NO concentrations and determined how these affected HIF-1alpha stability.	tet	88-100	nitric oxide synthase 2	Homo sapiens	36-57
12952868-0	2003	Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum.	tet	47-59	huntingtin	Rattus norvegicus	106-116
14597760-4	2003	The Ad was engineered to exhibit inducible TRAIL under the control of the doxycycline-inducible (DOX-inducible) tetracycline response element (TRE).	tet	112-124	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	43-48
14523478-5	2003	Similarly, induction of LMP1 in the 3A4 cells (exposed to tetracycline) was accompanied by a 13-fold increase in lymphotoxin levels (ELISA) as compared to uninduced (LMP1-negative) cells.	tet	58-70	PDZ and LIM domain 7	Homo sapiens	24-28
14531732-2	2003	In order to avoid the pitfalls associated with the use of NO donors, we have developed a human cell line (Tet-iNOS 293) that expresses the inducible NO synthase (iNOS) under the control of a tetracycline-inducible promoter.	tet	191-203	nitric oxide synthase 2	Homo sapiens	110-114
14531732-2	2003	In order to avoid the pitfalls associated with the use of NO donors, we have developed a human cell line (Tet-iNOS 293) that expresses the inducible NO synthase (iNOS) under the control of a tetracycline-inducible promoter.	tet	191-203	nitric oxide synthase 2	Homo sapiens	139-160
14531732-2	2003	In order to avoid the pitfalls associated with the use of NO donors, we have developed a human cell line (Tet-iNOS 293) that expresses the inducible NO synthase (iNOS) under the control of a tetracycline-inducible promoter.	tet	191-203	nitric oxide synthase 2	Homo sapiens	162-166
14647152-8	2003	Switching on expression of TRAIL by adding tetracycline to the drinking water of the mice strongly reduced tumour growth by apoptosis in a caspase-dependent manner.	tet	43-55	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	27-32
14709803-4	2003	We have utilized the tetracycline regulatory (tet-on) system to generate an in vitro model system to allow us to further investigate IGF-I/IGF-IR function in mammary epithelial cells.	tet	21-33	insulin like growth factor 1	Homo sapiens	133-138
14709803-4	2003	We have utilized the tetracycline regulatory (tet-on) system to generate an in vitro model system to allow us to further investigate IGF-I/IGF-IR function in mammary epithelial cells.	tet	21-33	insulin like growth factor 1 receptor	Homo sapiens	139-145
14634089-5	2003	Tetracycline-based conditional expression of BTG1 not only suppressed microglial proliferation but also increased the sensitivity of microglial cells to NO-induced apoptosis, suggesting a novel mechanism of cooperation between LPS and IFN-gamma in the induction of microglial apoptosis.	tet	0-12	BTG anti-proliferation factor 1	Mus musculus	45-49
14634089-5	2003	Tetracycline-based conditional expression of BTG1 not only suppressed microglial proliferation but also increased the sensitivity of microglial cells to NO-induced apoptosis, suggesting a novel mechanism of cooperation between LPS and IFN-gamma in the induction of microglial apoptosis.	tet	0-12	toll-like receptor 4	Mus musculus	227-230
14634089-5	2003	Tetracycline-based conditional expression of BTG1 not only suppressed microglial proliferation but also increased the sensitivity of microglial cells to NO-induced apoptosis, suggesting a novel mechanism of cooperation between LPS and IFN-gamma in the induction of microglial apoptosis.	tet	0-12	interferon gamma	Mus musculus	235-244
14627842-3	2003	We show here that a chimeric tetracycline- controlled transcription factor, encompassing the Tet repressor (TetR) from the tetracycline-resistance operon (tet from Escherichia coli transposon Tn10) and a cell membrane transducing peptide, is able to regulate transcription from a tetracycline responsive promoter (pCMV2xtetO2).	tet	29-41	tetracycline resistance repressor protein TetR	Escherichia coli	108-112
14627842-3	2003	We show here that a chimeric tetracycline- controlled transcription factor, encompassing the Tet repressor (TetR) from the tetracycline-resistance operon (tet from Escherichia coli transposon Tn10) and a cell membrane transducing peptide, is able to regulate transcription from a tetracycline responsive promoter (pCMV2xtetO2).	tet	123-135	tetracycline resistance repressor protein TetR	Escherichia coli	108-112
14627842-3	2003	We show here that a chimeric tetracycline- controlled transcription factor, encompassing the Tet repressor (TetR) from the tetracycline-resistance operon (tet from Escherichia coli transposon Tn10) and a cell membrane transducing peptide, is able to regulate transcription from a tetracycline responsive promoter (pCMV2xtetO2).	tet	123-135	tetracycline resistance repressor protein TetR	Escherichia coli	108-112
14627842-4	2003	When added directly to cultured cells, TetR fused to the full-length Antennapedia homeodomain (AntpHD) from Drosophila (TetRAntp), was able to selectively repress transcription in cells transiently transfected with a tetracycline-regulated reporter transcription unit.	tet	217-229	tetracycline resistance repressor protein TetR	Escherichia coli	39-43
14642075-2	2003	METHODS: HCT116 human colon carcinoma cells were transfected with pTRE-Gadd45 vector so as to establish Gadd45-inducible cell line that was cultured in medium with tetracycline.	tet	164-176	growth arrest and DNA damage inducible alpha	Homo sapiens	104-110
14642075-8	2003	RESULTS: Gadd45 protein was not expressed in the HCT116 cells cultured in the medium with tetracycline, however, it was expressed with a gradually increased level in the cells cultured in the medium from which tetracycline was withdrawn, The clone formation rate of HCT116 cells was 100% in the medium with tetracycline, however, was only 14.2% in the medium with tetracycline withdrawal, with a suppression rate of more than 85%.	tet	90-102	growth arrest and DNA damage inducible alpha	Homo sapiens	9-15
14642075-8	2003	RESULTS: Gadd45 protein was not expressed in the HCT116 cells cultured in the medium with tetracycline, however, it was expressed with a gradually increased level in the cells cultured in the medium from which tetracycline was withdrawn, The clone formation rate of HCT116 cells was 100% in the medium with tetracycline, however, was only 14.2% in the medium with tetracycline withdrawal, with a suppression rate of more than 85%.	tet	210-222	growth arrest and DNA damage inducible alpha	Homo sapiens	9-15
14642075-8	2003	RESULTS: Gadd45 protein was not expressed in the HCT116 cells cultured in the medium with tetracycline, however, it was expressed with a gradually increased level in the cells cultured in the medium from which tetracycline was withdrawn, The clone formation rate of HCT116 cells was 100% in the medium with tetracycline, however, was only 14.2% in the medium with tetracycline withdrawal, with a suppression rate of more than 85%.	tet	210-222	growth arrest and DNA damage inducible alpha	Homo sapiens	9-15
14642075-8	2003	RESULTS: Gadd45 protein was not expressed in the HCT116 cells cultured in the medium with tetracycline, however, it was expressed with a gradually increased level in the cells cultured in the medium from which tetracycline was withdrawn, The clone formation rate of HCT116 cells was 100% in the medium with tetracycline, however, was only 14.2% in the medium with tetracycline withdrawal, with a suppression rate of more than 85%.	tet	210-222	growth arrest and DNA damage inducible alpha	Homo sapiens	9-15
14578170-1	2003	Conditional expression of estrogen receptor (ER)-alpha) was introduced into tetracycline-responsive MMTV-tTA/tetop-TAg mice to develop a mouse model of estrogen-responsive ER-alpha-positive mammary adenocarcinoma.	tet	76-88	temporal alpha-galactosidase	Mus musculus	115-118
14981905-3	2003	MATERIALS AND METHODS: We established a tetracycline-inducible RbAp46 expression system in Saos-2 cells to test the effects of RbAp46 induction on cell growth in vitro and on tumor formation in vivo.	tet	40-52	RB binding protein 7, chromatin remodeling factor	Homo sapiens	63-69
12855552-3	2003	Here, we describe a new model of an inducible BCR/ABL disease by directing the expression of the oncogene to megakaryocytic progenitor cells within the murine bone marrow using the tetracycline-responsive expression system under the control of human CD34 regulatory elements.	tet	181-193	BCR activator of RhoGEF and GTPase	Mus musculus	46-53
12855552-3	2003	Here, we describe a new model of an inducible BCR/ABL disease by directing the expression of the oncogene to megakaryocytic progenitor cells within the murine bone marrow using the tetracycline-responsive expression system under the control of human CD34 regulatory elements.	tet	181-193	CD34 molecule	Homo sapiens	250-254
14612517-0	2003	Switching off HER-2/neu in a tetracycline-controlled mouse tumor model leads to apoptosis and tumor-size-dependent remission.	tet	29-41	erb-b2 receptor tyrosine kinase 2	Mus musculus	14-23
14572633-2	2003	Applying the tetracycline-inducible expression system Tet-On, we found overexpression of Bcl-X(S) by itself sufficient to induce apoptosis in vitro in stably transfected human melanoma cell lines.	tet	13-25	BCL2 like 1	Homo sapiens	89-94
12941952-5	2003	Interference with IGF-II production by a tetracycline-inhibited adenovirus expressing an IGF-II cDNA in the antisense orientation reversibly inhibited both production of muscle-specific structural proteins and myocyte fusion to form multinucleated myotubes.	tet	41-53	insulin-like growth factor 2	Mus musculus	18-24
12941952-5	2003	Interference with IGF-II production by a tetracycline-inhibited adenovirus expressing an IGF-II cDNA in the antisense orientation reversibly inhibited both production of muscle-specific structural proteins and myocyte fusion to form multinucleated myotubes.	tet	41-53	insulin-like growth factor 2	Mus musculus	89-95
12941952-6	2003	Similar results were achieved with a tetracycline-inhibited adenovirus expressing dominant-negative Akt.	tet	37-49	thymoma viral proto-oncogene 1	Mus musculus	100-103
14550576-2	2003	Here, we generated a cell line MCM7(+/-)/MCM7-FLAG, in which one allele of MCM7 is mutated whereas a tetracycline-repressible promoter could manipulate the expression of exogenous MCM7 protein.	tet	101-113	minichromosome maintenance complex component 7	Homo sapiens	31-35
14550576-2	2003	Here, we generated a cell line MCM7(+/-)/MCM7-FLAG, in which one allele of MCM7 is mutated whereas a tetracycline-repressible promoter could manipulate the expression of exogenous MCM7 protein.	tet	101-113	minichromosome maintenance complex component 7	Homo sapiens	41-45
14550576-2	2003	Here, we generated a cell line MCM7(+/-)/MCM7-FLAG, in which one allele of MCM7 is mutated whereas a tetracycline-repressible promoter could manipulate the expression of exogenous MCM7 protein.	tet	101-113	minichromosome maintenance complex component 7	Homo sapiens	41-45
14550576-2	2003	Here, we generated a cell line MCM7(+/-)/MCM7-FLAG, in which one allele of MCM7 is mutated whereas a tetracycline-repressible promoter could manipulate the expression of exogenous MCM7 protein.	tet	101-113	minichromosome maintenance complex component 7	Homo sapiens	41-45
14507662-1	2003	Recent research has shown that the tetracycline antibiotics are pluripotent drugs that inhibit the activity of matrix metalloproteinases (MMPs) and affect many cellular functions including proliferation, migration, and matrix remodeling.	tet	35-47	matrix metallopeptidase 2	Rattus norvegicus	138-142
14708986-3	2003	Sequence analysis showed that the plasmid pJR1 contained six major genes: the first gene (sulII) encoded a type II sulfonamide resistant dihydropteroate synthase, the second gene (tetG) encoded a tetracycline resistance protein, the third gene (catB2) encoded a chloramphenicol acetyltransferase, the fourth gene (rep) encoded a replication protein, and the fifth and sixth genes (mbeCy and deltambeAy) encoded proteins involved in the mobilization of plasmid.	tet	196-208	SulII	Pasteurella multocida	90-95
14708986-3	2003	Sequence analysis showed that the plasmid pJR1 contained six major genes: the first gene (sulII) encoded a type II sulfonamide resistant dihydropteroate synthase, the second gene (tetG) encoded a tetracycline resistance protein, the third gene (catB2) encoded a chloramphenicol acetyltransferase, the fourth gene (rep) encoded a replication protein, and the fifth and sixth genes (mbeCy and deltambeAy) encoded proteins involved in the mobilization of plasmid.	tet	196-208	TetG	Pasteurella multocida	180-184
14516475-6	2003	Remarkably, conditional expression of betaTrCP-E-cadherin under the control of a tetracycline-repressive promoter in DLD1 cells selectively knocked down the cytosolic, but not membrane-associated subpopulation of beta-catenin.	tet	81-93	cadherin 1	Homo sapiens	47-57
14555488-4	2003	This was achieved by placing one copy of the NRG1 gene (a negative regulator of filamentation) under the control of a tetracycline-regulatable promoter.	tet	118-130	transcriptional regulator NRG1	Saccharomyces cerevisiae S288C	45-49
14532204-11	2003	The bifunctional enzyme AAC6"-APH2" was detected in the isolate resistant to aminoglycosides, and other genetic determinants were identified in other resistant isolates: tetM and tetO in tetracycline-resistant streptococci and mefA and ermTR for efflux-mediated and inducible macrolide-lincosamide-streptogramin B-resistant streptococci, respectively.	tet	187-199	zinc finger DHHC-type palmitoyltransferase 16	Homo sapiens	24-34
14517281-12	2003	Significantly, we also showed that overexpression of 14-3-3 sigma inhibited oncogene-activated tumorigenicity in a tetracycline-regulated 14-3-3 sigma system.	tet	115-127	stratifin	Homo sapiens	53-65
14517281-12	2003	Significantly, we also showed that overexpression of 14-3-3 sigma inhibited oncogene-activated tumorigenicity in a tetracycline-regulated 14-3-3 sigma system.	tet	115-127	stratifin	Homo sapiens	138-150
12736135-0	2003	An ecdysone and tetracycline dual regulatory expression system for studies on Rac1 small GTPase-mediated signaling.	tet	16-28	Rac family small GTPase 1	Canis lupus familiaris	78-82
12812521-7	2003	20 h. Amyloid fibril morphology in the presence of tetracycline, as measured by transmission electron microscopy, was characterized by short fragmented fibrils compared with the longer and denser appearance of fibrils formed by amylin alone.	tet	51-63	islet amyloid polypeptide	Homo sapiens	228-234
12917336-3	2003	To study the mechanism of cell cycle arrest, we established a tetracycline-inducible expression system for PTEN in cell lines lacking this gene.	tet	62-74	phosphatase and tensin homolog	Homo sapiens	107-111
12895476-2	2003	), based on the finding that H(2)O(2) in the europium (III)-tetracycline-hydrogen peroxide system is consumed by catalase.	tet	60-72	catalase	Homo sapiens	113-121
12923567-8	2003	Furthermore, the use of a liver cell-specific human alpha1-antitrypsin (hAAT)-promoter driving a tetracycline-controlled transcriptional silencer allowed specific protection of cells with hAAT-promoter activity in the absence of dox in vitro and in vivo, delineating a new principle of "tissue protective" gene therapy.	tet	97-109	serpin family A member 1	Homo sapiens	52-70
12952598-1	2003	We previously developed single adenovirus (Ad) vectors that contained the components for a tetracycline-regulatable gene-expression system in the E1 and E3 deletion regions, and showed that the Ad vectors containing the tet-on system exhibit a much inferior regulation of transgene expression than those containing the tet-off system.	tet	91-103	small nucleolar RNA, H/ACA box 73A	Homo sapiens	146-154
12901858-3	2003	Since NLK may be a tumor suppressor as a negative regulator of Wnt/beta-catenin pathway, we established tetracycline-inducible NLK and its kinase-negative mutant expression in DLD-1 human colon cancer cells to analyze the effect of NLK on cell growth and viability.	tet	104-116	nemo like kinase	Homo sapiens	6-9
14503850-9	2003	To examine these interactions in vivo, we established a tetracycline-regulatable Hela cell line that expresses Hsp70 in the absence of doxycycline.	tet	56-68	heat shock protein family A (Hsp70) member 4	Homo sapiens	111-116
12714527-6	2003	Examination of KC mRNA expressed under control of a tetracycline-responsive promoter demonstrated that TGFbeta prevented stabilization of KC mRNA, in response to LPS but did not alter KC mRNA half-life directly.	tet	52-64	transforming growth factor, beta 1	Mus musculus	103-110
12925279-1	2003	To examine the role of C/EBP-related transcription factors in long-term synaptic plasticity and memory storage, we have used the tetracycline-regulated system and expressed in the forebrain of mice a broad dominant-negative inhibitor of C/EBP (EGFP-AZIP), which preferentially interacts with several inhibiting isoforms of C/EBP.	tet	129-141	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	23-28
12871726-0	2003	Enhanced expression of uridine diphosphate-N-acetylglucosaminyl transferase (OGT) in a stable, tetracycline-inducible HeLa cell line using histone deacetylase inhibitors: kinetics of cytosolic OGT accumulation and nuclear translocation.	tet	95-107	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	77-80
12871726-1	2003	We have created a stable, tetracycline-inducible HeLa cell line that overexpresses murine uridine diphosphate-N-acetylglucosaminyl transferase (OGT).	tet	26-38	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	144-147
12871726-2	2003	Tetracycline increased cytosolic OGT activity about 4-fold in a dose-dependent manner (ED(50)=0.03 microg/ml) with enhanced activity observable at 8h and maximal activity observable by 40h.	tet	0-12	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	33-36
12871726-4	2003	Trichostatin A (TSA), a potent and specific histone deacetylase inhibitor (HDI), markedly enhanced tetracycline-induced OGT gene expression, resulting in a >10-fold increase in OGT activity (>50-fold compared to that of uninduced cells).	tet	99-111	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	120-123
12871726-4	2003	Trichostatin A (TSA), a potent and specific histone deacetylase inhibitor (HDI), markedly enhanced tetracycline-induced OGT gene expression, resulting in a >10-fold increase in OGT activity (>50-fold compared to that of uninduced cells).	tet	99-111	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	180-183
12907644-2	2003	We established previously a stable clone of the rat small intestinal epithelial cell line IEC6, which is capable of inducing stabilized beta-catenin protein lacking NH(2)-terminal glycogen synthase kinase-3beta phosphorylation site under a strict control of the tetracycline-regulatory system.	tet	262-274	catenin beta 1	Rattus norvegicus	136-148
12901858-3	2003	Since NLK may be a tumor suppressor as a negative regulator of Wnt/beta-catenin pathway, we established tetracycline-inducible NLK and its kinase-negative mutant expression in DLD-1 human colon cancer cells to analyze the effect of NLK on cell growth and viability.	tet	104-116	nemo like kinase	Homo sapiens	127-130
12901858-3	2003	Since NLK may be a tumor suppressor as a negative regulator of Wnt/beta-catenin pathway, we established tetracycline-inducible NLK and its kinase-negative mutant expression in DLD-1 human colon cancer cells to analyze the effect of NLK on cell growth and viability.	tet	104-116	nemo like kinase	Homo sapiens	127-130
12882905-4	2003	Glucose intolerance in Munc18c transgenic mice was reversed by repression of transgene expression using tetracycline or by simultaneous overexpression of Syn4 protein.	tet	104-116	syntaxin binding protein 3	Mus musculus	23-30
12865351-1	2003	This study reports the characterization of a recombinant adenoviral vector containing a tetracycline-regulatable promoter, driving the bicistronic expression of the human H2 preprorelaxin (hH2) cDNA and enhanced green fluorescent protein, via an internal ribosomal entry site.	tet	88-100	relaxin 2	Homo sapiens	171-187
12882934-4	2003	To further examine the mechanisms by which PKG regulates TSP1 expression and TSP1-dependent TGF-beta activation, we generated stably transfected rat mesangial cells (RMCs) with inducible expression tetracycline-induced gene expression of the catalytic domain of PKG.	tet	198-210	thrombospondin 1	Rattus norvegicus	57-61
12882934-4	2003	To further examine the mechanisms by which PKG regulates TSP1 expression and TSP1-dependent TGF-beta activation, we generated stably transfected rat mesangial cells (RMCs) with inducible expression tetracycline-induced gene expression of the catalytic domain of PKG.	tet	198-210	thrombospondin 1	Rattus norvegicus	77-81
12882934-4	2003	To further examine the mechanisms by which PKG regulates TSP1 expression and TSP1-dependent TGF-beta activation, we generated stably transfected rat mesangial cells (RMCs) with inducible expression tetracycline-induced gene expression of the catalytic domain of PKG.	tet	198-210	transforming growth factor, beta 1	Rattus norvegicus	92-100
12865351-1	2003	This study reports the characterization of a recombinant adenoviral vector containing a tetracycline-regulatable promoter, driving the bicistronic expression of the human H2 preprorelaxin (hH2) cDNA and enhanced green fluorescent protein, via an internal ribosomal entry site.	tet	88-100	relaxin 2	Homo sapiens	189-192
12766164-0	2003	Second-site suppressor mutations for the serine 202 to phenylalanine substitution within the interdomain loop of the tetracycline efflux protein Tet(C).	tet	117-129	hypothetical protein	Escherichia coli	145-151
12874453-7	2003	Administration of tetracycline in the drinking water was associated with podocyte expression of beta-galactosidase, in a fashion that was time dependent (maximal at 1 wk) and dose-dependent (maximal at 2 mg/ml).	tet	18-30	galactosidase, beta 1	Mus musculus	96-114
12766164-1	2003	The serine 202 to phenylalanine substitution within the cytoplasmic interdomain loop of Tet(C) greatly reduces tetracycline resistance and efflux activity (Saraceni-Richards, C. A., and Levy, S. B.	tet	111-123	hypothetical protein	Escherichia coli	88-94
12885904-1	2003	We have previously reported the construction and characterization of an inducible recombinant virus in which expression of the vaccinia virus membrane protein A14 is experimentally regulated using the tetracycline operator-repressor system.	tet	201-213	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	159-162
12869643-9	2003	The conditional expression of the CDC25A gene using a tetracycline repressor expression vector increased sensitivity toward ART.	tet	54-66	cell division cycle 25A	Homo sapiens	34-40
12801999-1	2003	PURPOSE: To design and evaluate a construct that allows regulated expression of the magnetic resonance (MR) imaging reporter gene human tyrosinase under control of the tetracycline response element.	tet	168-180	tyrosinase	Homo sapiens	136-146
12801999-3	2003	In this construct, the reporter gene human tyrosinase is under control of the tetracycline response element, thus allowing suppression of gene expression by adding doxycycline (tetracycline switched off).	tet	78-90	tyrosinase	Homo sapiens	43-53
12801999-3	2003	In this construct, the reporter gene human tyrosinase is under control of the tetracycline response element, thus allowing suppression of gene expression by adding doxycycline (tetracycline switched off).	tet	177-189	tyrosinase	Homo sapiens	43-53
12857957-6	2003	Infection of cells from beta-actin TVA transgenic mice with this vector permits efficient regulation of tet-responsive transgenes.	tet	104-107	actin, beta	Mus musculus	24-34
12857957-7	2003	Sarcomas arise when p53-deficient murine embryonic fibroblasts carrying beta-actin TVA and tet-o-K-ras4bG12D transgenes are infected with RCAS-rtTA-IRES-GFP and introduced into nude mice treated with the tet analog, doxycycline (dox); when dox is withdrawn, K-ras4bG12D levels fall, cells undergo apoptosis, and tumors regress.	tet	91-94	transformation related protein 53, pseudogene	Mus musculus	20-23
12829995-5	2003	In the present study, amineptine, amiodarone, pirprofen, tetracycline, and tianeptine, but not doxycycline, inhibited MTP activity in vitro, decreased ex vivo MTP activity in the hepatic homogenate of treated mice, decreased TG in the luminal VLDL fraction of hepatic microsomes of treated mice, and decreased in vivo hepatic lipoprotein secretion (TG and Apo B).	tet	57-69	microsomal triglyceride transfer protein	Mus musculus	118-121
12831835-0	2003	Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: application for detecting androgens and antiandrogens.	tet	31-43	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	83-89
12831835-1	2003	Differential expression of the tetracycline-controlled transactivator (tTA)-driven human cytochrome p450 (CYP) 1B1 gene was found in the livers of male mice, at high levels in neonates, but at low levels in adults.	tet	31-43	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	89-114
12878048-8	2003	Treatment of HeLa cells with doxycycline, a tetracycline analogue, induced the expression of MT-IIA, which attenuated the effect of PDTC on NF-kappaB activity.	tet	44-56	nuclear factor kappa B subunit 1	Homo sapiens	140-149
12829995-5	2003	In the present study, amineptine, amiodarone, pirprofen, tetracycline, and tianeptine, but not doxycycline, inhibited MTP activity in vitro, decreased ex vivo MTP activity in the hepatic homogenate of treated mice, decreased TG in the luminal VLDL fraction of hepatic microsomes of treated mice, and decreased in vivo hepatic lipoprotein secretion (TG and Apo B).	tet	57-69	microsomal triglyceride transfer protein	Mus musculus	159-162
12829995-5	2003	In the present study, amineptine, amiodarone, pirprofen, tetracycline, and tianeptine, but not doxycycline, inhibited MTP activity in vitro, decreased ex vivo MTP activity in the hepatic homogenate of treated mice, decreased TG in the luminal VLDL fraction of hepatic microsomes of treated mice, and decreased in vivo hepatic lipoprotein secretion (TG and Apo B).	tet	57-69	apolipoprotein B	Mus musculus	356-361
12790803-0	2003	Tetracycline-regulated secretion of human insulin in a transfected non-endocrine cell line.	tet	0-12	insulin	Homo sapiens	42-49
12882905-0	2003	Insulin resistance in tetracycline-repressible Munc18c transgenic mice.	tet	22-34	syntaxin binding protein 3	Mus musculus	47-54
12857871-4	2003	To test this model, we generated tetracycline-inducible cell lines overexpressing wild-type and kinase-dead versions of Nek2A.	tet	33-45	NIMA related kinase 2	Homo sapiens	120-125
12821944-4	2003	The enforced expression of BCR-ABL in an ES cell line, engineered to express a tetracycline-inducible dominant-negative form of a STAT3, triggered ES cell differentiation with an increased generation of hematopoietic cells expressing erythroid and megakaryocytic phenotypes.	tet	79-91	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	27-34
12821944-4	2003	The enforced expression of BCR-ABL in an ES cell line, engineered to express a tetracycline-inducible dominant-negative form of a STAT3, triggered ES cell differentiation with an increased generation of hematopoietic cells expressing erythroid and megakaryocytic phenotypes.	tet	79-91	signal transducer and activator of transcription 3	Homo sapiens	130-135
12810633-4	2003	Therefore, we created two cell lines in which a transfected human MDR1 cDNA is repressed by tetracycline and induced in the absence of tetracycline.	tet	92-104	ATP binding cassette subfamily B member 1	Homo sapiens	66-70
12810633-4	2003	Therefore, we created two cell lines in which a transfected human MDR1 cDNA is repressed by tetracycline and induced in the absence of tetracycline.	tet	135-147	ATP binding cassette subfamily B member 1	Homo sapiens	66-70
12759248-7	2003	Inhibition of FGF-2 production by tetracycline caused a significant decrease in tumor burden paralleled by a decrease in blood vessel density and size.	tet	34-46	fibroblast growth factor 2	Homo sapiens	14-19
12736219-6	2003	Specifically, we generated lines of mice that express Klf4 from a tetracycline inducible promoter when crossed with transgenic mice expressing the tetracycline transactivator tTA from the epidermal keratin 5 promoter.	tet	66-78	Kruppel-like factor 4 (gut)	Mus musculus	54-58
12790803-11	2003	After a 48-h incubation with 1.0 microg/ml tetracycline, total pro/insulin levels were 10 and 14% compared with untreated cells respectively.	tet	43-55	insulin	Homo sapiens	67-74
12790803-12	2003	On tetracycline removal, total proinsulin levels increased and were equivalent to untreated groups 72 h later.	tet	3-15	insulin	Homo sapiens	31-41
12791823-3	2003	METHODS: (67)Ga and (59)Fe uptakes were measured in HeLa cells transfected with a FLAG-tagged wild-type HFE (fHFE) gene under control of a tetracycline-repressible promoter.	tet	139-151	homeostatic iron regulator	Homo sapiens	104-107
12850461-2	2003	We hypothesized that COL-3, a chemically modified tetracycline known to inhibit MMP-2 and MMP-9, would reduce lung injury and improve survival in rats following cecal ligation and puncture (CLP).	tet	50-62	matrix metallopeptidase 2	Rattus norvegicus	80-85
12850461-2	2003	We hypothesized that COL-3, a chemically modified tetracycline known to inhibit MMP-2 and MMP-9, would reduce lung injury and improve survival in rats following cecal ligation and puncture (CLP).	tet	50-62	matrix metallopeptidase 9	Rattus norvegicus	90-95
12732722-4	2003	Here we report the development of a stringently regulated, tetracycline-inducible, lung-specific transgenic system that allows regulated expression of KGF in the lung without causing developmental abnormalities from leaky KGF expression.	tet	59-71	fibroblast growth factor 7	Mus musculus	151-154
12732722-4	2003	Here we report the development of a stringently regulated, tetracycline-inducible, lung-specific transgenic system that allows regulated expression of KGF in the lung without causing developmental abnormalities from leaky KGF expression.	tet	59-71	fibroblast growth factor 7	Mus musculus	222-225
12706249-5	2003	In the present study, we took advantage of this property and generated transgenic mice, using the tetracycline gene regulation system, that support the inducible, brain region-specific expression of a dominant negative mutant form of c-Jun (Deltac-Jun), which can antagonize the actions of Fos proteins.	tet	98-110	jun proto-oncogene	Mus musculus	234-239
12624110-6	2003	In stable transfectants, tetracycline-induced expression of DEC1 caused proportional decreases in the expression of DEC2.	tet	25-37	deleted in esophageal cancer 1	Homo sapiens	60-64
12624110-6	2003	In stable transfectants, tetracycline-induced expression of DEC1 caused proportional decreases in the expression of DEC2.	tet	25-37	basic helix-loop-helix family member e41	Homo sapiens	116-120
12721802-2	2003	Although the M protein gene could be cloned into hAdVs and expressed constituvely in 293 cells under the control of the hCMV immediate early promotor/enhancer, hAdVs expressing N and GP(5) proteins, which appeared to be toxic or interfered with adenovirus replication, could only be generated by inclusion of a tetracycline-regulatable promotor in the transfer vector pAdTR5.	tet	311-323	myomesin 2	Homo sapiens	13-22
12709570-4	2003	To temporally control the expression of HO-1, we used a one-plasmid tetracycline (tet)-inducible system.	tet	68-80	heme oxygenase 1	Rattus norvegicus	40-44
12709570-4	2003	To temporally control the expression of HO-1, we used a one-plasmid tetracycline (tet)-inducible system.	tet	68-71	heme oxygenase 1	Rattus norvegicus	40-44
12709570-5	2003	This plasmid contains the H-2K(b) promoter, which transcribes the tet transactivator (tTA) and expression of a human HO-1 cDNA is obtained in the absence of tetracycline.	tet	157-169	heme oxygenase 1	Homo sapiens	117-121
12709570-9	2003	Expression levels of transgene-derived HO-1 increased after withdrawal of tet compared with transgenic rats maintained with tet, as detected by analysis of mRNA levels by quantitative real-time reverse transcription polymerase chain reaction.	tet	74-77	heme oxygenase 1	Rattus norvegicus	39-43
12709570-9	2003	Expression levels of transgene-derived HO-1 increased after withdrawal of tet compared with transgenic rats maintained with tet, as detected by analysis of mRNA levels by quantitative real-time reverse transcription polymerase chain reaction.	tet	124-127	heme oxygenase 1	Rattus norvegicus	39-43
12717387-0	2003	Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis.	tet	12-24	transforming growth factor, beta 1	Mus musculus	49-58
12717387-1	2003	Based on the tetracycline-regulated gene expression system, a double-transgenic mouse model for liver fibrosis was established in which the expression of transforming growth factor beta1 (TGF-beta1) can be regulated deliberately by addition or removal of doxycycline hydrochloride to the drinking water.	tet	13-25	transforming growth factor, beta 1	Mus musculus	154-186
12717387-1	2003	Based on the tetracycline-regulated gene expression system, a double-transgenic mouse model for liver fibrosis was established in which the expression of transforming growth factor beta1 (TGF-beta1) can be regulated deliberately by addition or removal of doxycycline hydrochloride to the drinking water.	tet	13-25	transforming growth factor, beta 1	Mus musculus	188-197
12697895-7	2003	With this method, glutaredoxin, monitored by Western blot, was knocked out by overexpressing 290-base sense and antisense RNA in NIH 3T3 cells controlled by tetracycline or doxycycline.	tet	157-169	glutaredoxin	Mus musculus	18-30
12590145-7	2003	In HeLa cells expressing SPA-1 in a tetracycline-regulatory manner, expression of AF-6 inhibited endogenous Rap1GTP and beta(1) integrin-mediated cell adhesion to fibronectin in SPA-1-induced conditions, whereas it affected neither of them in SPA-1-repressed conditions.	tet	36-48	signal-induced proliferation-associated 1	Homo sapiens	25-30
12590145-7	2003	In HeLa cells expressing SPA-1 in a tetracycline-regulatory manner, expression of AF-6 inhibited endogenous Rap1GTP and beta(1) integrin-mediated cell adhesion to fibronectin in SPA-1-induced conditions, whereas it affected neither of them in SPA-1-repressed conditions.	tet	36-48	afadin, adherens junction formation factor	Homo sapiens	82-86
12705902-0	2003	Tetracycline-regulated secretion of human insulin in transfected primary myoblasts.	tet	0-12	insulin	Homo sapiens	42-49
12705902-2	2003	In this study, a two-plasmid tetracycline-inducible system was used to regulate expression of human proinsulin (hppI1) and a mutated proinsulin construct (hppI4, allowing cleavage by furin) in primary rat soleus myoblasts.	tet	29-41	insulin	Homo sapiens	100-110
12705902-2	2003	In this study, a two-plasmid tetracycline-inducible system was used to regulate expression of human proinsulin (hppI1) and a mutated proinsulin construct (hppI4, allowing cleavage by furin) in primary rat soleus myoblasts.	tet	29-41	insulin	Homo sapiens	133-143
12705902-2	2003	In this study, a two-plasmid tetracycline-inducible system was used to regulate expression of human proinsulin (hppI1) and a mutated proinsulin construct (hppI4, allowing cleavage by furin) in primary rat soleus myoblasts.	tet	29-41	furin, paired basic amino acid cleaving enzyme	Homo sapiens	183-188
12705902-3	2003	In hppI1 and hppI4 transient transfections, the presence of 0.01 and 0.1 microg/ml tetracycline for 48 h inhibited pro/insulin secretion to 19-27% and 7-12%, respectively, compared to tetracycline untreated myoblasts.	tet	83-95	insulin	Homo sapiens	119-126
12705902-4	2003	Following a 48 h tetracycline incubation (1.0 microg/ml), pro/insulin secretion in hppI1 and hppI4 transfected myoblasts was reduced to <4% of that in cells incubated without tetracycline.	tet	17-29	insulin	Homo sapiens	62-69
12705902-5	2003	Pro/insulin secretion equivalent to that of untreated cells was restored following tetracycline withdrawal and incubation for a further 72 h. Conversion of proinsulin to insulin in transfected myoblasts was <1% for hppI1 and >45% for hppI4.	tet	83-95	insulin	Homo sapiens	156-166
12705902-5	2003	Pro/insulin secretion equivalent to that of untreated cells was restored following tetracycline withdrawal and incubation for a further 72 h. Conversion of proinsulin to insulin in transfected myoblasts was <1% for hppI1 and >45% for hppI4.	tet	83-95	insulin	Homo sapiens	159-166
12706249-5	2003	In the present study, we took advantage of this property and generated transgenic mice, using the tetracycline gene regulation system, that support the inducible, brain region-specific expression of a dominant negative mutant form of c-Jun (Deltac-Jun), which can antagonize the actions of Fos proteins.	tet	98-110	FBJ osteosarcoma oncogene	Mus musculus	290-293
12702563-2	2003	We have used microPET and fluorescence imaging to detect interactions between p53 tumor suppressor and large T antigen (TAg) of SV40 virus in a tetracycline-inducible two-hybrid system.	tet	144-156	tumor protein p53	Homo sapiens	78-81
12514180-3	2003	In 293 cell clones, in which PP2C alpha expression is regulated by a tetracycline-inducible promoter, PP2C alpha overexpression led to G(2)/M cell cycle arrest and apoptosis.	tet	69-81	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	29-39
12514180-3	2003	In 293 cell clones, in which PP2C alpha expression is regulated by a tetracycline-inducible promoter, PP2C alpha overexpression led to G(2)/M cell cycle arrest and apoptosis.	tet	69-81	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	102-112
12702563-2	2003	We have used microPET and fluorescence imaging to detect interactions between p53 tumor suppressor and large T antigen (TAg) of SV40 virus in a tetracycline-inducible two-hybrid system.	tet	144-156	long intergenic non-protein coding RNA 1194	Homo sapiens	120-123
12676559-4	2003	We have produced complete and reversible inactivation of the Hoxa2 gene in the mouse using the control elements of the tetracycline-resistance operon.	tet	119-131	homeobox A2	Mus musculus	61-66
12676559-5	2003	We show that a Hoxa2 allele containing tetracycline operator (tetO) sequences is susceptible to controlled regulation by tTS, a chimeric molecule containing the tetracycline repressor and a transcriptional repressing domain.	tet	39-51	homeobox A2	Mus musculus	15-20
12676559-5	2003	We show that a Hoxa2 allele containing tetracycline operator (tetO) sequences is susceptible to controlled regulation by tTS, a chimeric molecule containing the tetracycline repressor and a transcriptional repressing domain.	tet	161-173	homeobox A2	Mus musculus	15-20
12565711-7	2003	Transcription of both ODC-CAT and endogenous odc was strongly induced in HeLa cells expressing tetracycline-regulated c-Myc, concomitant with c-Myc promoting the S-phase entry of the cells.	tet	95-107	ornithine decarboxylase 1	Homo sapiens	22-25
12565711-7	2003	Transcription of both ODC-CAT and endogenous odc was strongly induced in HeLa cells expressing tetracycline-regulated c-Myc, concomitant with c-Myc promoting the S-phase entry of the cells.	tet	95-107	ornithine decarboxylase 1	Homo sapiens	45-48
12565711-7	2003	Transcription of both ODC-CAT and endogenous odc was strongly induced in HeLa cells expressing tetracycline-regulated c-Myc, concomitant with c-Myc promoting the S-phase entry of the cells.	tet	95-107	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	118-123
12839676-2	2003	METHODS: One self-contained tetracycline-regulated retroviral vector containing anti-sense cDNA of MMP-9 was constructed and transfected into a metastatic human melanoma cell line WM451 which expressed a high level of MMP-9.	tet	28-40	matrix metallopeptidase 9	Homo sapiens	99-104
12634378-0	2003	Global changes in Kaposi"s sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator.	tet	103-115	ORF50	Human gammaherpesvirus 8	126-129
12634378-4	2003	The Rta transcriptional activator, which acts as a molecular switch for lytic reactivation of KSHV, was efficiently integrated downstream of the Flp recombination target site, and its expression was tightly controlled by tetracycline.	tet	221-233	ORF50	Human gammaherpesvirus 8	4-7
12839676-2	2003	METHODS: One self-contained tetracycline-regulated retroviral vector containing anti-sense cDNA of MMP-9 was constructed and transfected into a metastatic human melanoma cell line WM451 which expressed a high level of MMP-9.	tet	28-40	matrix metallopeptidase 9	Homo sapiens	218-223
12839676-5	2003	RESULTS: In the presence of exogenous tetracycline, the transfected antisense MMP-9 did not affect the endogenous level of MMP-9 in WM451 cells, and showed no significant changes in cell behaviors in comparison with that of the vector-transfected control cells.	tet	38-50	matrix metallopeptidase 9	Homo sapiens	78-83
12839676-6	2003	Nevertheless, withdrawal of tetracycline from the medium caused a significant down-regulation of expression and activity of MMP-9.	tet	28-40	matrix metallopeptidase 9	Homo sapiens	124-129
12626594-6	2003	Both exogenous MIF and endogenous MIF, induced following overexpression through tetracycline (tet) gene induction, led to significant suppression of apoptosis.	tet	80-92	macrophage migration inhibitory factor	Homo sapiens	15-18
12626534-3	2003	We used the tetracycline-inducible system to conditionally express murine Flt3 ligand (FL), a potent hemopoietic growth factor that promotes the differentiation and mobilization of DC.	tet	12-24	FMS-like tyrosine kinase 3 ligand	Mus musculus	74-85
12626594-6	2003	Both exogenous MIF and endogenous MIF, induced following overexpression through tetracycline (tet) gene induction, led to significant suppression of apoptosis.	tet	80-92	macrophage migration inhibitory factor	Homo sapiens	34-37
12626534-3	2003	We used the tetracycline-inducible system to conditionally express murine Flt3 ligand (FL), a potent hemopoietic growth factor that promotes the differentiation and mobilization of DC.	tet	12-24	FMS-like tyrosine kinase 3 ligand	Mus musculus	87-89
12626594-6	2003	Both exogenous MIF and endogenous MIF, induced following overexpression through tetracycline (tet) gene induction, led to significant suppression of apoptosis.	tet	80-83	macrophage migration inhibitory factor	Homo sapiens	15-18
12626534-4	2003	Acute treatment (96 h) of the transgenic animals with the tetracycline analog doxycycline (DOX) promoted an approximately 200-fold increase in serum levels of FL without affecting the number of circulating DC.	tet	58-70	FMS-like tyrosine kinase 3 ligand	Mus musculus	159-161
12626594-6	2003	Both exogenous MIF and endogenous MIF, induced following overexpression through tetracycline (tet) gene induction, led to significant suppression of apoptosis.	tet	80-83	macrophage migration inhibitory factor	Homo sapiens	34-37
12626594-11	2003	A role for MIF in oxidative stress-induced apoptosis was directly studied in HL-60 leukocytes and tet-regulated HeLa cells following thiol starvation or diamide treatment.	tet	98-101	macrophage migration inhibitory factor	Homo sapiens	11-14
12920800-2	2003	METHODS: One self-contained tetracycline-regulated retroviral vector containing sense cDNA of MMP-9 was constructed and transfected into an early-stage human melanoma cell line WM35, which did not express MMP-9.	tet	28-40	matrix metallopeptidase 9	Homo sapiens	94-99
12604780-3	2003	The present work describes the biochemical consequences of FAP48 overexpression, induced by the tetracycline analogue doxycycline, in an established cell line derived from Jurkat T cells.	tet	96-108	glomulin, FKBP associated protein	Homo sapiens	59-64
12824923-4	2003	p21(WAF1) expression induced by removal of tetracycline from culture media repressed cell proliferation and resulted in altered cell shape, suggesting induction of differentiation.	tet	43-55	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
12824923-4	2003	p21(WAF1) expression induced by removal of tetracycline from culture media repressed cell proliferation and resulted in altered cell shape, suggesting induction of differentiation.	tet	43-55	cyclin dependent kinase inhibitor 1A	Homo sapiens	4-8
12529379-3	2003	In this study we investigated the calcium dependence of human TRPM2 expressed under a tetracycline-dependent promoter in HEK-293 cells.	tet	86-98	transient receptor potential cation channel subfamily M member 2	Homo sapiens	62-67
12920800-4	2003	RESULTS: In the presence of exogenous tetracycline, the expression of the transfected MMP-9 were under detectable level and no significant changes in cell behaviors were found when compared with vector-transfected control cells.	tet	38-50	matrix metallopeptidase 9	Homo sapiens	86-91
12920800-5	2003	But when the tetracycline was withdrew from the medium, the expression and activity of MMP-9 were significantly increased.	tet	13-25	matrix metallopeptidase 9	Homo sapiens	87-92
12475969-8	2003	Functional activity was also demonstrated in vivo with stably transfected HeLa cells expressing eIF4G-1(DM) from a tetracycline-regulated promoter.	tet	115-127	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	96-103
12586388-4	2003	SERT expression in the three different inducible stable mammalian cell lines was induced either by a decrease in temperature (cell line pCytTS-SERT), the addition of tetracycline to the growth medium (cell line T-REx-SERT) or by adding DMSO which caused the cells to differentiate (cell line MEL-SERT).	tet	166-178	solute carrier family 6 member 4	Homo sapiens	0-4
12554695-3	2003	By in vivo injection of either Matrigel plugs containing Par1-expressing cells or of rat prostatic carcinoma cells transfected with tetracycline-inducible Par1 expression vectors, we show that Par1 significantly enhances both angiogenesis and tumor growth.	tet	132-144	coagulation factor II (thrombin) receptor	Rattus norvegicus	155-159
12388075-2	2003	We used a tetracycline-inducible system to control the expression of wild-type (SGK(wt)(T)), constitutively active (S425D mutation; SGK(S425D)(T)), or inactive (K130M mutation; SGK(K130M)(T)) SGK in A6 cells independently of hormonal stimulation.	tet	10-22	serum/glucocorticoid regulated kinase 1	Homo sapiens	80-83
12388075-2	2003	We used a tetracycline-inducible system to control the expression of wild-type (SGK(wt)(T)), constitutively active (S425D mutation; SGK(S425D)(T)), or inactive (K130M mutation; SGK(K130M)(T)) SGK in A6 cells independently of hormonal stimulation.	tet	10-22	serum/glucocorticoid regulated kinase 1	Homo sapiens	132-135
12388075-2	2003	We used a tetracycline-inducible system to control the expression of wild-type (SGK(wt)(T)), constitutively active (S425D mutation; SGK(S425D)(T)), or inactive (K130M mutation; SGK(K130M)(T)) SGK in A6 cells independently of hormonal stimulation.	tet	10-22	serum/glucocorticoid regulated kinase 1	Homo sapiens	132-135
12388075-2	2003	We used a tetracycline-inducible system to control the expression of wild-type (SGK(wt)(T)), constitutively active (S425D mutation; SGK(S425D)(T)), or inactive (K130M mutation; SGK(K130M)(T)) SGK in A6 cells independently of hormonal stimulation.	tet	10-22	serum/glucocorticoid regulated kinase 1	Homo sapiens	132-135
12645954-1	2003	To better understand loss of self-tolerance in diabetes-prone NOD mice, we are generating ICA69 transgenes under control of the tetracycline-regulated tet07 minimal promoter.	tet	128-140	islet cell autoantigen 1	Mus musculus	90-95
12554695-3	2003	By in vivo injection of either Matrigel plugs containing Par1-expressing cells or of rat prostatic carcinoma cells transfected with tetracycline-inducible Par1 expression vectors, we show that Par1 significantly enhances both angiogenesis and tumor growth.	tet	132-144	coagulation factor II (thrombin) receptor	Rattus norvegicus	155-159
12624953-3	2003	To study the effect of dominant-negative inhibitor GSE22 on the p53 activity, cultures coexpressing GSE22 and tetracycline-suppressible p53 were derived from p53-negative cell lines.	tet	110-122	tumor protein p53	Homo sapiens	136-139
12525645-3	2003	The present report demonstrates for the first time that ASF/SF2 is required under physiological conditions for the expression of BPV-1 late RNAs and for selection of the proximal 3" splice site for BPV-1 RNA splicing in DT40-ASF cells, a genetically engineered chicken B-cell line that expresses only human ASF/SF2 controlled by a tetracycline-repressible promoter.	tet	331-343	serine and arginine rich splicing factor 1	Homo sapiens	56-63
12525645-3	2003	The present report demonstrates for the first time that ASF/SF2 is required under physiological conditions for the expression of BPV-1 late RNAs and for selection of the proximal 3" splice site for BPV-1 RNA splicing in DT40-ASF cells, a genetically engineered chicken B-cell line that expresses only human ASF/SF2 controlled by a tetracycline-repressible promoter.	tet	331-343	serine and arginine rich splicing factor 1	Homo sapiens	56-59
12525645-4	2003	Depletion of ASF/SF2 from the cells by tetracycline greatly decreased viral RNA expression and RNA splicing at the proximal 3" splice site while increasing use of the distal 3" splice site in the remaining viral RNAs.	tet	39-51	serine and arginine rich splicing factor 1	Homo sapiens	13-20
12519399-10	2003	The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups.	tet	23-49	interleukin 6	Homo sapiens	177-181
12519399-10	2003	The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups.	tet	23-49	interleukin 1 beta	Homo sapiens	183-192
12519399-10	2003	The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups.	tet	23-49	tumor necrosis factor	Homo sapiens	194-203
12519399-10	2003	The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups.	tet	23-49	interleukin 1 receptor antagonist	Homo sapiens	280-286
12519399-10	2003	The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups.	tet	23-35	interleukin 6	Homo sapiens	177-181
12519399-10	2003	The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups.	tet	23-35	interleukin 1 beta	Homo sapiens	183-192
12519399-10	2003	The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups.	tet	23-35	tumor necrosis factor	Homo sapiens	194-203
12519399-10	2003	The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups.	tet	23-35	interleukin 1 receptor antagonist	Homo sapiens	280-286
12624953-3	2003	To study the effect of dominant-negative inhibitor GSE22 on the p53 activity, cultures coexpressing GSE22 and tetracycline-suppressible p53 were derived from p53-negative cell lines.	tet	110-122	tumor protein p53	Homo sapiens	136-139
12467970-10	2002	A conditional null mutant, containing a tetracycline-inducible ectopic Ty1-MRE11, exhibited reduced growth and plating efficiency and increased sensitivity to DNA double-strand breaks, induced by methyl methanesulphonate or ionizing radiation, in the absence of tetracycline.	tet	40-52	MRX complex nuclease subunit	Saccharomyces cerevisiae S288C	75-80
12475623-4	2003	At 512 microg/ml none of the compounds displayed any antibacterial activity but individually in combination with tetracycline and erythromycin, a two-fold potentiation of the activities of these antibiotics was observed against two strains of S. aureus that were highly resistant to these agents due to the presence of the multidrug efflux mechanisms Tet(K) (tetracycline resistance) and Msr(A) (macrolide resistance).	tet	113-125	ABC transporter permease protein	Staphylococcus aureus	388-394
12817781-5	2003	Moreover, BAL cells isolated from calves treated with both NSAIDs were still able, ex vivo, to release TNF, in contrast to the control group (treated only with tetracycline) which lost the ability to produce TNF.	tet	160-172	tumor necrosis factor	Bos taurus	208-211
12413887-4	2002	Ubc9 disappeared 3 days after the addition of tetracycline and the increase in viable cell number stopped 4 days after the addition of drug.	tet	46-58	E2 SUMO-conjugating protein UBC9	Saccharomyces cerevisiae S288C	0-4
12427308-0	2002	Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington"s disease.	tet	83-95	ciliary neurotrophic factor	Rattus norvegicus	41-68
12427308-2	2002	In the present work, we used tetracycline (Tet)-regulated lentiviral vectors to investigate the dose-dependent neuroprotective effect of human ciliary neurotrophic factor (CNTF) in the quinolinic acid (QA) model of Huntington"s disease (HD).	tet	29-41	ciliary neurotrophic factor	Homo sapiens	172-176
12427308-2	2002	In the present work, we used tetracycline (Tet)-regulated lentiviral vectors to investigate the dose-dependent neuroprotective effect of human ciliary neurotrophic factor (CNTF) in the quinolinic acid (QA) model of Huntington"s disease (HD).	tet	43-46	ciliary neurotrophic factor	Homo sapiens	143-170
12427308-2	2002	In the present work, we used tetracycline (Tet)-regulated lentiviral vectors to investigate the dose-dependent neuroprotective effect of human ciliary neurotrophic factor (CNTF) in the quinolinic acid (QA) model of Huntington"s disease (HD).	tet	43-46	ciliary neurotrophic factor	Homo sapiens	172-176
12479698-4	2002	As a potential therapeutic approach to address this concern, the work presented here measured the molecular consequences of adding a chemically modified tetracycline (CMT-3; COL-3) that inhibits MMP activity to aggressive metastatic melanoma cells in three-dimensional culture.	tet	153-165	matrix metallopeptidase 2	Homo sapiens	195-198
12504573-3	2002	Using the epithelial cell line HeLa in which the expression of LMP1 is inducibly regulated by tetracycline, we demonstrate that apoptosis triggered by ligation of the death receptor, Fas, or by the chemotherapeutic agent, etoposide, is potentiated by LMP1.	tet	94-106	PDZ and LIM domain 7	Homo sapiens	63-67
12393582-7	2002	Analysis of transgenic human CD34-tTA mice by cross breeding with a strain carrying Cre recombinase under control of a tetracycline-responsive element demonstrated induction of Cre expression in mice in a pattern consistent with the expression of the human CD34 transgene.	tet	119-131	CD34 molecule	Homo sapiens	29-33
12393582-7	2002	Analysis of transgenic human CD34-tTA mice by cross breeding with a strain carrying Cre recombinase under control of a tetracycline-responsive element demonstrated induction of Cre expression in mice in a pattern consistent with the expression of the human CD34 transgene.	tet	119-131	CD34 molecule	Homo sapiens	257-261
12471059-3	2002	We developed a new transgenic mouse model where muscle specific utrophin expression was conditioned by addition of tetracycline in water.	tet	115-127	utrophin	Mus musculus	64-72
12374798-2	2002	We investigated possible alterations of MUC2 gene expression by p53 and p21(Sdi1/Waf1/Cip1) in a human colon cancer cell line, DLD-1, establishing subclones in which a tetracycline-regulatable promoter controls exogenous p53 and p21 expression.	tet	168-180	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	40-44
12374798-2	2002	We investigated possible alterations of MUC2 gene expression by p53 and p21(Sdi1/Waf1/Cip1) in a human colon cancer cell line, DLD-1, establishing subclones in which a tetracycline-regulatable promoter controls exogenous p53 and p21 expression.	tet	168-180	tumor protein p53	Homo sapiens	221-224
12374798-2	2002	We investigated possible alterations of MUC2 gene expression by p53 and p21(Sdi1/Waf1/Cip1) in a human colon cancer cell line, DLD-1, establishing subclones in which a tetracycline-regulatable promoter controls exogenous p53 and p21 expression.	tet	168-180	cyclin dependent kinase inhibitor 1A	Homo sapiens	229-232
12498714-1	2002	To determine the impact of tumor progression on the reversibility of Neu-induced tumorigenesis, we have used the tetracycline regulatory system to conditionally express activated Neu in the mammary epithelium of transgenic mice.	tet	113-125	erb-b2 receptor tyrosine kinase 2	Mus musculus	179-182
12445619-2	2002	Making use of the TRAIL gene expression system in Jurkat as a cell model, we studied the influence of TRAIL gene on the biomechanics properties of Jurkat through measuring changes of cellular biomechanics properties before and after the TRAIL gene expression, which was induced by adding tetracycline derivative doxycycline (Dox).	tet	288-300	TNF superfamily member 10	Homo sapiens	102-107
12445619-2	2002	Making use of the TRAIL gene expression system in Jurkat as a cell model, we studied the influence of TRAIL gene on the biomechanics properties of Jurkat through measuring changes of cellular biomechanics properties before and after the TRAIL gene expression, which was induced by adding tetracycline derivative doxycycline (Dox).	tet	288-300	TNF superfamily member 10	Homo sapiens	102-107
12451607-3	2002	To investigate the role of SK3 channels in denervation- induced hyperexcitability, SK3 expression was manipulated using a transgenic mouse that harbors a tetracycline-regulated SK3 gene.	tet	154-166	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	83-86
12451607-3	2002	To investigate the role of SK3 channels in denervation- induced hyperexcitability, SK3 expression was manipulated using a transgenic mouse that harbors a tetracycline-regulated SK3 gene.	tet	154-166	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	83-86
12498775-5	2002	beta-Thalassemic mice were rendered steadily normocythemic by the intramuscular injection of a tetracycline-inducible AAV vector encoding mouse Epo.	tet	95-107	erythropoietin	Mus musculus	144-147
12509133-6	2002	Here, we review experiences that were made from using a tetracycline-inducible promotor system (tTA-system) to express TNFalpha at various times during an ongoing autoimmune process, such as the destruction of pancreatic beta-cells in a mouse model for human type 1 diabetes.	tet	56-68	tumor necrosis factor	Mus musculus	119-127
12438277-5	2002	BDNF treatment of high TrkB-expressing TB8 (Tet-) and TB3 (Tet-) cells blocked drug-induced cell death in a dose-dependent manner.	tet	44-47	brain derived neurotrophic factor	Homo sapiens	0-4
12438277-5	2002	BDNF treatment of high TrkB-expressing TB8 (Tet-) and TB3 (Tet-) cells blocked drug-induced cell death in a dose-dependent manner.	tet	44-47	neurotrophic receptor tyrosine kinase 2	Homo sapiens	23-27
12438277-5	2002	BDNF treatment of high TrkB-expressing TB8 (Tet-) and TB3 (Tet-) cells blocked drug-induced cell death in a dose-dependent manner.	tet	59-62	brain derived neurotrophic factor	Homo sapiens	0-4
12226077-4	2002	To understand the role of p85 betaPIX in basic fibroblast growth factor (bFGF)-induced neurite outgrowth, we established PC12 cell lines that overexpress the fibroblast growth factor receptor-1 in a tetracycline-inducible manner.	tet	199-211	Fibroblast growth factor receptor 1	Rattus norvegicus	158-193
12416990-6	2002	To analyze the potential role of eEF-2K in regulating protein synthesis by pH, we constructed a mouse fibroblast cell line that expresses eEF-2K in a tetracycline-regulated manner.	tet	150-162	eukaryotic elongation factor-2 kinase	Mus musculus	138-144
12376355-4	2002	To test our hypothesis, using the tetracycline gene regulatory system, we have generated a transgenic mouse model with the features of inducible, lung-specific uPA production.	tet	34-46	plasminogen activator, urokinase	Mus musculus	160-163
12547236-3	2002	We here describe our recent work on patch-clamp capacitance measurements in stably transfected HeLa cells expressing HFE, the hereditary hemochromatosis gene product, under the control of a tetracycline-sensitive promotor.	tet	190-202	homeostatic iron regulator	Homo sapiens	117-120
12439598-8	2002	Treatment of cells with PD98059 or UO126 after cisplatin incubation or inhibition of signaling through ERK by tetracycline-regulated expression of dominant-inhibitory ERK enhanced resistance to cisplatin in p53-negative osteosarcoma cells and reduced cisplatin-induced apoptosis.	tet	110-122	mitogen-activated protein kinase 1	Homo sapiens	103-106
12439598-8	2002	Treatment of cells with PD98059 or UO126 after cisplatin incubation or inhibition of signaling through ERK by tetracycline-regulated expression of dominant-inhibitory ERK enhanced resistance to cisplatin in p53-negative osteosarcoma cells and reduced cisplatin-induced apoptosis.	tet	110-122	mitogen-activated protein kinase 1	Homo sapiens	167-170
12439598-8	2002	Treatment of cells with PD98059 or UO126 after cisplatin incubation or inhibition of signaling through ERK by tetracycline-regulated expression of dominant-inhibitory ERK enhanced resistance to cisplatin in p53-negative osteosarcoma cells and reduced cisplatin-induced apoptosis.	tet	110-122	tumor protein p53	Homo sapiens	207-210
12467970-10	2002	A conditional null mutant, containing a tetracycline-inducible ectopic Ty1-MRE11, exhibited reduced growth and plating efficiency and increased sensitivity to DNA double-strand breaks, induced by methyl methanesulphonate or ionizing radiation, in the absence of tetracycline.	tet	262-274	MRX complex nuclease subunit	Saccharomyces cerevisiae S288C	75-80
12409460-8	2002	Finally, we demonstrated conditional 3-iodo-L-tyrosine incorporation, regulated by inducible expression of the TyrRS(V37C195) gene from a tetracycline-regulated promoter.	tet	138-150	tyrosyl-tRNA synthetase 1	Homo sapiens	111-116
12381793-8	2002	By using stably transformed HeLa cells with the tetracycline on/off expression system, reduction of cellular NRF by expressing antisense NRF increased basal iNOS promoter activity and resulted in constitutive iNOS mRNA expression.	tet	48-60	NFKB repressing factor	Homo sapiens	109-112
12381793-8	2002	By using stably transformed HeLa cells with the tetracycline on/off expression system, reduction of cellular NRF by expressing antisense NRF increased basal iNOS promoter activity and resulted in constitutive iNOS mRNA expression.	tet	48-60	NFKB repressing factor	Homo sapiens	137-140
12386811-9	2002	Using the tetracycline-inducible system (tet-off), we have found that over-expression of ATF3 protein moderately suppresses cell growth.	tet	10-22	activating transcription factor 3	Homo sapiens	89-93
12388791-1	2002	We have developed a system utilizing the murine Tie2 promoter/enhancer coupled with the "tetracycline-on" regulatory elements to create a model that allows regulated and selective expression of a beta-galactosidase (betaGal) reporter transgene in the adult murine vascular endothelium.	tet	89-101	galactosidase, beta 1	Mus musculus	196-214
12388791-1	2002	We have developed a system utilizing the murine Tie2 promoter/enhancer coupled with the "tetracycline-on" regulatory elements to create a model that allows regulated and selective expression of a beta-galactosidase (betaGal) reporter transgene in the adult murine vascular endothelium.	tet	89-101	galactosidase, beta 1	Mus musculus	216-223
12119049-7	2002	Stable transfectants with a tetracycline-inducible construct demonstrated that DEC1 caused proliferation inhibition, antagonized serum deprivation-induced apoptosis and selectively inhibited the activation of procaspases.	tet	28-40	deleted in esophageal cancer 1	Homo sapiens	79-83
12119049-8	2002	These activities were highly correlated with the abundance of tetracycline-induced DEC1.	tet	62-74	deleted in esophageal cancer 1	Homo sapiens	83-87
12119049-10	2002	Enzymic assays and immunoblotting analyses demonstrated that induction of DEC1 by tetracycline significantly decreased the activation of procaspases 3, 7 and 9 but not procaspase 8.	tet	82-94	deleted in esophageal cancer 1	Homo sapiens	74-78
12360481-3	2002	In this study, we sought to better dissect the mechanism and develop potentially more effective IGF-Ir-targeted therapeutics by developing and testing tetracycline-regulated and recombinant adenoviruses expressing dominant negative receptors.	tet	151-163	insulin like growth factor 1 receptor	Homo sapiens	96-102
12370422-0	2002	Structure and function in rhodopsin: a tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants.	tet	39-51	rhodopsin	Homo sapiens	26-35
12370423-0	2002	Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line.	tet	125-137	rhodopsin	Homo sapiens	26-35
12370423-0	2002	Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line.	tet	125-137	rhodopsin	Homo sapiens	62-71
12370423-3	2002	The tetracycline-inducible opsin expression system was assembled into this GnTI(-) HEK293S cell line.	tet	4-16	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	75-79
12360481-6	2002	RESULTS: Activation of IGF-Ir/tf expression by withdrawal of tetracycline suppressed tumorigenicity both in vitro and in vivo and up-regulated stressor-induced apoptosis.	tet	61-73	insulin like growth factor 1 receptor	Homo sapiens	23-29
12360481-4	2002	METHODS: Truncated IGF-I receptors (IGF-Ir/tf; 482 and 950 amino acids long, respectively [IGF-Ir/482st and IGF-Ir/950st]) were cloned into tetracycline-regulated vectors and recombinant adenoviruses and then studied in colorectal cancer cells.	tet	140-152	insulin like growth factor 1	Homo sapiens	19-24
12416540-1	2002	We have expressed the tumor suppressor p16 under the control of a tetracycline-sensitive promoter in two human glioblastoma cell lines which do not contain endogenous p16.	tet	66-78	cyclin dependent kinase inhibitor 2A	Homo sapiens	39-42
12416540-4	2002	p16 expression in these tumors was strictly dependent on the presence or absence of tetracycline in the drinking water.	tet	84-96	cyclin dependent kinase inhibitor 2A	Mus musculus	0-3
12215528-2	2002	Using tetracycline-regulated promoters we performed, during a transcriptional induction, a complete analysis of the maturation of two cellular mRNAs, those for LT-alpha and beta-globin.	tet	6-18	lymphotoxin alpha	Homo sapiens	160-168
12215528-2	2002	Using tetracycline-regulated promoters we performed, during a transcriptional induction, a complete analysis of the maturation of two cellular mRNAs, those for LT-alpha and beta-globin.	tet	6-18	hemoglobin subunit beta	Homo sapiens	173-184
12206802-2	2002	This includes preliminary results on tetracycline-controlled expression of utrophin.	tet	37-49	utrophin	Mus musculus	75-83
12234998-2	2002	We have measured the formation and nucleotide excision repair of covalent DNA adducts formed by the DNA-reactive metabolite of this compound in human fibroblasts, in which expression of the p53 tumor suppressor gene could be controlled by a tetracycline-inducible promoter.	tet	241-253	tumor protein p53	Homo sapiens	190-193
12086581-10	2002	In a HeLa-cell tetracycline-regulated reporter system, overexpression of the p42 CBF-A isoform resulted in stabilization of a COX-2 ARE reporter mRNA.	tet	15-27	erythrocyte membrane protein band 4.2	Homo sapiens	77-80
12086581-10	2002	In a HeLa-cell tetracycline-regulated reporter system, overexpression of the p42 CBF-A isoform resulted in stabilization of a COX-2 ARE reporter mRNA.	tet	15-27	Y-box binding protein 1	Homo sapiens	81-86
12392602-6	2002	In contrast to cells produced using the CMV and PGK promoters, those produced using the EF1alpha and TRE promoters expressed high levels of beta-galactosidase in a tetracycline-dependent manner.	tet	164-176	eukaryotic translation initiation factor 1A	Mus musculus	88-96
12209829-5	2002	Tetracycline-regulated co-expression of a ST3Gal I fragment, cloned in the antisense orientation, and of C2GnT cDNA resulted in inhibition of the ST3Gal I enzymatic activity and increase in C2GnT activity which varied depending on the extent of tetracycline reduction in the cell culture medium.	tet	0-12	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	105-110
12209829-5	2002	Tetracycline-regulated co-expression of a ST3Gal I fragment, cloned in the antisense orientation, and of C2GnT cDNA resulted in inhibition of the ST3Gal I enzymatic activity and increase in C2GnT activity which varied depending on the extent of tetracycline reduction in the cell culture medium.	tet	0-12	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	190-195
12209829-5	2002	Tetracycline-regulated co-expression of a ST3Gal I fragment, cloned in the antisense orientation, and of C2GnT cDNA resulted in inhibition of the ST3Gal I enzymatic activity and increase in C2GnT activity which varied depending on the extent of tetracycline reduction in the cell culture medium.	tet	245-257	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	105-110
12209829-5	2002	Tetracycline-regulated co-expression of a ST3Gal I fragment, cloned in the antisense orientation, and of C2GnT cDNA resulted in inhibition of the ST3Gal I enzymatic activity and increase in C2GnT activity which varied depending on the extent of tetracycline reduction in the cell culture medium.	tet	245-257	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	190-195
12392602-6	2002	In contrast to cells produced using the CMV and PGK promoters, those produced using the EF1alpha and TRE promoters expressed high levels of beta-galactosidase in a tetracycline-dependent manner.	tet	164-176	galactosidase, beta 1	Mus musculus	140-158
12176907-1	2002	A tetracycline-controlled expression system was adapted to the human promyelocytic HL-60 cell line by placement of the transactivator (tTA-off) sequence under the control of the human EF-1alpha promoter region.	tet	2-14	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	184-193
12149459-4	2002	The incubation with tetracycline hydrochloride or doxycycline hyclate at concentrations ranging from 10 microM to 1 mM resulted in a dose-dependent decrease in protease resistance of PrP(Sc).	tet	20-46	PRP@	Bos taurus	183-186
12169577-4	2002	HK-II was overexpressed in A549 cells in a tetracycline-repressible retroviral vector system.	tet	43-55	hexokinase 2	Homo sapiens	0-5
12198708-4	2002	METHODS: The effect of galectin-3 on MUC2 mucin production was assessed by stable transfection of sense and antisense galectin-3 expression constructs under the control of constitutive or tetracycline-inducible promoters into human colon cancer cells.	tet	188-200	galectin 3	Homo sapiens	23-33
12163372-9	2002	The functional significance of CLIC4 was analyzed in MEF/3T3 fibroblasts by conditional expression using the tetracycline-repressive gene regulation system.	tet	109-121	chloride intracellular channel 4	Homo sapiens	31-36
12121918-1	2002	We have developed a method for visualizing Escherichia coli cells that are exposed to tetracycline in a biofilm, based on a previous report that liposomes containing the E. coli TetR(B) protein fluoresce when exposed to this antibiotic.	tet	86-98	tetracycline resistance repressor protein TetR	Escherichia coli	178-182
12121918-2	2002	By our method, cells devoid of TetR(B) also exhibited tetracycline-dependent fluorescence.	tet	54-66	tetracycline resistance repressor protein TetR	Escherichia coli	31-35
12202219-4	2002	When the structural proteins (core-E1-E2) of HCV genotype 1 were expressed in human osteosarcoma cells in a tetracycline-regulated manner, partial VSV resistance to IFN-alpha was established.	tet	108-120	interferon alpha 1	Homo sapiens	165-174
12101414-0	2002	A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo.	tet	15-27	BCL2 associated X, apoptosis regulator	Homo sapiens	76-79
12101414-5	2002	The hTERT promoter drives the expression of tTA, a transactivator capable of binding to TRE (tetracycline-responsive element) in the absence of tetracycline, which in turn induces expression of the GFP-Bax gene.	tet	93-105	telomerase reverse transcriptase	Homo sapiens	4-9
12101414-5	2002	The hTERT promoter drives the expression of tTA, a transactivator capable of binding to TRE (tetracycline-responsive element) in the absence of tetracycline, which in turn induces expression of the GFP-Bax gene.	tet	93-105	BCL2 associated X, apoptosis regulator	Homo sapiens	202-205
12101414-6	2002	The addition of tetracycline in 293 cells blocks the binding of tTA to TRE and substantially inhibits GFP-Bax expression and toxicity, thus allowing the packaging and production of Ad/gBax.	tet	16-28	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
12096336-6	2002	Using tetracycline-regulated retroviral vectors for conditional expression of p53 mutants, we found that transcription of the dUTPase gene is increased within 24 h after tetracycline withdrawal, and the cells acquire higher resistance to 5-FU.	tet	6-18	tumor protein p53	Homo sapiens	78-81
12096336-6	2002	Using tetracycline-regulated retroviral vectors for conditional expression of p53 mutants, we found that transcription of the dUTPase gene is increased within 24 h after tetracycline withdrawal, and the cells acquire higher resistance to 5-FU.	tet	6-18	Deoxyuridine triphosphatase	Drosophila melanogaster	126-133
12096336-6	2002	Using tetracycline-regulated retroviral vectors for conditional expression of p53 mutants, we found that transcription of the dUTPase gene is increased within 24 h after tetracycline withdrawal, and the cells acquire higher resistance to 5-FU.	tet	170-182	tumor protein p53	Homo sapiens	78-81
12096336-6	2002	Using tetracycline-regulated retroviral vectors for conditional expression of p53 mutants, we found that transcription of the dUTPase gene is increased within 24 h after tetracycline withdrawal, and the cells acquire higher resistance to 5-FU.	tet	170-182	Deoxyuridine triphosphatase	Drosophila melanogaster	126-133
12072405-5	2002	S9 cells expressing a tetracycline-regulated sense AS3 were also used.	tet	22-34	PDS5 cohesin associated factor B	Rattus norvegicus	51-54
12074549-6	2002	To test that the effect of the mutation observed in the mammary gland was organ-autonomous, we developed a tetracycline-binary system whereby CSF-1 was specifically expressed in the mammary epithelium under the regulation of the MMTV-promoter.	tet	107-119	colony stimulating factor 1 (macrophage)	Mus musculus	142-147
12074549-8	2002	Inhibition of CSF-1 expression by tetracycline treatment for varying periods suggested that CSF-1-regulated macrophages are required throughout early mammary gland development.	tet	34-46	colony stimulating factor 1 (macrophage)	Mus musculus	14-19
12074549-8	2002	Inhibition of CSF-1 expression by tetracycline treatment for varying periods suggested that CSF-1-regulated macrophages are required throughout early mammary gland development.	tet	34-46	colony stimulating factor 1 (macrophage)	Mus musculus	92-97
12138893-4	2002	We have developed an in vitro system that mirrors the chronic phase of CML with a combination of in vitro embryonic stem cell differentiation and tetracycline-inducible Bcr-Abl expression.	tet	146-158	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	169-176
12133271-0	2002	Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis.	tet	0-12	interleukin 10	Homo sapiens	23-37
12052872-4	2002	We have established clones of human lung (H1299) and breast (MCF7) cancer cells that express high levels of IRP1(C437S) in a tetracycline-inducible manner.	tet	125-137	aconitase 1	Homo sapiens	108-112
12097524-2	2002	We used transgenic mice carrying a tetracycline-regulated, calcium-independent form of CaMKII (CaMKII-Asp286) to investigate the role of CaMKII activation on synaptic plasticity and behavior.	tet	35-47	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	87-93
12097524-2	2002	We used transgenic mice carrying a tetracycline-regulated, calcium-independent form of CaMKII (CaMKII-Asp286) to investigate the role of CaMKII activation on synaptic plasticity and behavior.	tet	35-47	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	95-108
12097524-2	2002	We used transgenic mice carrying a tetracycline-regulated, calcium-independent form of CaMKII (CaMKII-Asp286) to investigate the role of CaMKII activation on synaptic plasticity and behavior.	tet	35-47	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	95-101
12065419-4	2002	Consistent with the phenotype of GATA-2 null animals, conditional expression of GATA-2 from a tetracycline-inducible promoter enhanced the production of hematopoietic progenitors.	tet	94-106	GATA binding protein 2	Mus musculus	33-39
12095303-6	2002	A single adenovirus that encodes the components necessary for tetracycline induction (IADR) expressed IFN-alpha in a ligand-dependent manner.	tet	62-74	interferon alpha	Mus musculus	102-111
12085193-4	2002	The tetracycline-inducible expression system was established in melanoma cells, and three fragments of the 5"-, central-, and 3"-portion of the eIF-4A1 cDNA were subcloned in antisense and in sense orientation after a tetracycline inducible promoter.	tet	4-16	eukaryotic translation initiation factor 4A1	Homo sapiens	144-151
12065419-4	2002	Consistent with the phenotype of GATA-2 null animals, conditional expression of GATA-2 from a tetracycline-inducible promoter enhanced the production of hematopoietic progenitors.	tet	94-106	GATA binding protein 2	Mus musculus	80-86
12115478-6	2002	Using A375 human melanoma cells and MCF7 human breast adenocarcinoma cells stably transfected with tetracycline regulatable Muc4, we have investigated whether overexpression of Muc4/SMC can repress antibody binding to cell surface-expressed ErbB2.	tet	99-111	mucin 4, cell surface associated	Homo sapiens	124-128
12126552-5	2002	Then, doxycycline one of tetracycline derivatives, was used to control the expression of insulin in these cells.	tet	25-37	insulin	Homo sapiens	89-96
12126552-10	2002	CONCLUSION: Human proinsulin gene was transfected successfully and expressed efficiently in 293 cells, and the expression was modulated by tetracycline and its derivatives, improving the accuracy, safety, and reliability for the gene therapy of diabetes mellitus.	tet	139-151	insulin	Homo sapiens	18-28
11991981-2	2002	In the present study, a tetracycline-inducible expression system expressing a constitutively active form of IRF-3 (IRF-3 5D) was combined with DNA microarray analysis to identify target genes regulated by IRF-3.	tet	24-36	interferon regulatory factor 3	Homo sapiens	108-113
12107556-3	2002	METHOD: A tetracycline-inducible retroviral expression vector bearing the human bax-alpha gene was constructed.	tet	10-22	BCL2 associated X, apoptosis regulator	Homo sapiens	80-83
12107556-6	2002	RESULTS: Western blots revealed that Bax expression was enhanced in these cells by the tetracycline analogue doxycycline.	tet	87-99	BCL2 associated X, apoptosis regulator	Homo sapiens	37-40
12012003-5	2002	This system allows VEGF gene expression to be manipulated in vivo by providing tetracycline in the drinking water.	tet	79-91	vascular endothelial growth factor A	Mus musculus	19-23
11991981-2	2002	In the present study, a tetracycline-inducible expression system expressing a constitutively active form of IRF-3 (IRF-3 5D) was combined with DNA microarray analysis to identify target genes regulated by IRF-3.	tet	24-36	interferon regulatory factor 3	Homo sapiens	115-120
11991981-2	2002	In the present study, a tetracycline-inducible expression system expressing a constitutively active form of IRF-3 (IRF-3 5D) was combined with DNA microarray analysis to identify target genes regulated by IRF-3.	tet	24-36	interferon regulatory factor 3	Homo sapiens	115-120
12021407-1	2002	To investigate the role of cAMP response element-binding protein (CREB) in the adaptive responses to psychotropic drugs, we have developed inducible, brain region-specific CREB transgenic mice using the tetracycline-regulated gene expression system.	tet	203-215	cAMP responsive element binding protein 1	Mus musculus	66-70
12021407-3	2002	Different patterns of CREB overexpression were found in striatum, nucleus accumbens, and cingulate cortex in different lines of bitransgenic mice, and CREB expression was blocked by addition of doxycycline, an analog of tetracycline.	tet	220-232	cAMP responsive element binding protein 1	Mus musculus	151-155
12021407-1	2002	To investigate the role of cAMP response element-binding protein (CREB) in the adaptive responses to psychotropic drugs, we have developed inducible, brain region-specific CREB transgenic mice using the tetracycline-regulated gene expression system.	tet	203-215	cAMP responsive element binding protein 1	Mus musculus	172-176
12021407-3	2002	Different patterns of CREB overexpression were found in striatum, nucleus accumbens, and cingulate cortex in different lines of bitransgenic mice, and CREB expression was blocked by addition of doxycycline, an analog of tetracycline.	tet	220-232	cAMP responsive element binding protein 1	Mus musculus	22-26
11888675-3	2002	When E7 was induced in the absence of tetracycline, the expression of target genes of IRF-1 (TAP-1, IFN-beta, MCP-1 that are important for cellular immunity) was clearly reduced as determined by RT-PCR.	tet	38-50	interferon regulatory factor 1	Homo sapiens	86-91
11983872-6	2002	We generated a transgenic mouse in which stabilized beta-catenin is expressed in mesenchymal cells under control of a tetracycline-regulated promoter.	tet	118-130	catenin (cadherin associated protein), beta 1	Mus musculus	52-64
11901157-5	2002	Indeed, homozygous GAS41-/- cell lines with two disrupted GAS41 alleles can be generated following substitution of the endogenous gene by stable integration of GAS41 cDNA controlled by a tetracycline-regulated CMV promoter.	tet	187-199	YEATS domain containing 4	Gallus gallus	19-24
11901157-5	2002	Indeed, homozygous GAS41-/- cell lines with two disrupted GAS41 alleles can be generated following substitution of the endogenous gene by stable integration of GAS41 cDNA controlled by a tetracycline-regulated CMV promoter.	tet	187-199	YEATS domain containing 4	Gallus gallus	58-63
11901157-5	2002	Indeed, homozygous GAS41-/- cell lines with two disrupted GAS41 alleles can be generated following substitution of the endogenous gene by stable integration of GAS41 cDNA controlled by a tetracycline-regulated CMV promoter.	tet	187-199	YEATS domain containing 4	Gallus gallus	58-63
11901157-6	2002	Inactivation of this promoter by tetracycline withdrawal results in rapid depletion of GAS41, causing a significant decrease in RNA synthesis and subsequently cell death.	tet	33-45	YEATS domain containing 4	Gallus gallus	87-92
12019148-2	2002	In this study, we examine the effects of mPlGF/PlGF-2 overexpression in tumors grown from glioma cells containing a tetracycline-regulated mPlGF cDNA.	tet	116-128	placental growth factor	Mus musculus	139-144
12019148-4	2002	When tetracycline is used to abruptly withdraw mPlGF overexpression, we see increased apoptosis in both vascular cells and macrophages.	tet	5-17	placental growth factor	Mus musculus	47-52
11867617-3	2002	We have investigated the role of tTGase in cell migration using two stably transfected fibroblast cell lines in which expression of tTGase in its active and inactive (C277S mutant) states is inducible through the tetracycline-regulated system.	tet	213-225	transglutaminase 2	Homo sapiens	33-39
11867617-3	2002	We have investigated the role of tTGase in cell migration using two stably transfected fibroblast cell lines in which expression of tTGase in its active and inactive (C277S mutant) states is inducible through the tetracycline-regulated system.	tet	213-225	transglutaminase 2	Homo sapiens	132-138
12112641-3	2002	METHODS: An Ad-mediated binary transgene expression system was generated containing a tet-off or a tet-on system, which introduced the gene of interest with a tetracycline-regulatable promoter and the tetracycline-responsive transcriptional activator gene into the E1 and E3 deletion regions, respectively.	tet	201-213	small nucleolar RNA, H/ACA box 73A	Homo sapiens	265-273
11880187-1	2002	Previously, we demonstrated the significance of vascular endothelial growth factor (VEGF) in promoting the growth of tetracycline-regulated human VEGF165 retroviral vector transduced T47-D breast carcinoma cells, particularly at the early stages of tumor development (Cancer Res.	tet	117-129	vascular endothelial growth factor A	Homo sapiens	48-82
11880187-1	2002	Previously, we demonstrated the significance of vascular endothelial growth factor (VEGF) in promoting the growth of tetracycline-regulated human VEGF165 retroviral vector transduced T47-D breast carcinoma cells, particularly at the early stages of tumor development (Cancer Res.	tet	117-129	vascular endothelial growth factor A	Homo sapiens	84-88
12975603-6	2002	Double tetracycline-calcein labeling revealed that the biglycan deficient mice are defective in their capacity to form bone.	tet	7-19	biglycan	Mus musculus	55-63
12003970-7	2002	Immediately after pulsing with tetracycline, the composition of the biofilms changed and they consisted of 30% lactobacilli, 1.5% streptococci and 3% Actinomyces spp., with a total anaerobic count of 1 x 10(7) cfu per biofilm.	tet	31-43	histocompatibility minor 13	Homo sapiens	162-165
11972078-0	2002	Fluorescent tetracycline labeling as an aid to debridement of necrotic bone in the treatment of chronic osteomyelitis.	tet	12-24	activation induced cytidine deaminase	Homo sapiens	40-43
12071645-11	2002	The purified WBLP was found to have high antibacterial activity in a thiocynate-H2O2 medium for some pathogenic bacteria, such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginose, Shigella sonnei, Staphylococcus saphrophyticus, Staphylococcus epidermidis, and Shigella dysenteriae and compared with well known antibacterial substances such as tetracycline, penicillin, and netilmicine.	tet	358-370	lactoperoxidase	Bubalus bubalis	13-17
11959891-4	2002	METHODS: Tetracycline-inducible (Tet-On) COX-2 antisense clones were isolated to assess the effect of COX-2 expression on cell viability and sensitivity to apoptosis induced by COX-2 inhibitors.	tet	9-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-46
12054596-13	2002	We used tetracycline-responsive expression vectors to obtain moderate expression of PPAR-gamma 4 and -gamma 5 in CHO cells.	tet	8-20	peroxisome proliferator activated receptor gamma	Homo sapiens	84-94
11884613-5	2002	When induced from a tetracycline-repressible promoter, RTP801 protected MCF7 and PC12 cells from hypoxia in glucose-free medium and from H(2)O(2)-triggered apoptosis via a dramatic reduction in the generation of reactive oxygen species.	tet	20-32	DNA-damage-inducible transcript 4	Rattus norvegicus	55-61
11925627-14	2002	CONCLUSION: Human proinsulin gene was transfected successfully and expressed efficiently in 293 cells, and the expression was modulated by tetracycline and its derivatives, improving the accuracy, safety, and reliability of gene therapy, suggesting that conditional establishment of artificial beta-cells may be a useful approach to develop cellular therapy for diabetes mellitus.	tet	139-151	insulin	Homo sapiens	18-28
11953454-2	2002	To study the specific role of caspase-3 activation in neuronal cells, we generated a stable tetracycline-regulated SK-N-MC neuroblastoma cell line, which expressed a highly efficient self-activating chimeric caspase-3, consisting of the caspase-1 prodomain fused to the caspase-3 catalytic domain.	tet	92-104	caspase 3	Homo sapiens	30-39
12419161-0	2002	Effects of tetracycline-controlled antisense bcl-2 expression on the growth and apoptosis of human neuroblastoma cell line SK-N-MC.	tet	11-23	BCL2 apoptosis regulator	Homo sapiens	45-50
12419161-1	2002	OBJECTIVE: To study the effects of tetracycline-controlled antisense bcl-2 expression on the growth and apoptosis of human neuroblastoma cell line SK-N-MC and the related mechanisms.	tet	35-47	BCL2 apoptosis regulator	Homo sapiens	69-74
12419161-2	2002	METHODS: The tetracycline-controlled antisense bcl-2 expressing vector PUCCOMB1(CMV)/Asbcl-2 was constructed by inserting a 0.6 kb fragment antisense bcl-2 cDNA sequence into the plasmid PUCCOMB1(CMV).	tet	13-25	BCL2 apoptosis regulator	Homo sapiens	47-52
12419161-2	2002	METHODS: The tetracycline-controlled antisense bcl-2 expressing vector PUCCOMB1(CMV)/Asbcl-2 was constructed by inserting a 0.6 kb fragment antisense bcl-2 cDNA sequence into the plasmid PUCCOMB1(CMV).	tet	13-25	BCL2 apoptosis regulator	Homo sapiens	87-92
12419161-4	2002	The transfectant cells were further studied for growth viability and apoptosis induced by antisense bcl-2 expression controlled by tetracycline.	tet	131-143	BCL2 apoptosis regulator	Homo sapiens	100-105
12419161-8	2002	CONCLUSIONS: The results suggested that tetracycline-controlled expression of antisense bcl-2 can effectively inhibit the cell viability of SK-N-MC cells, increase the sensitivity to apoptosis-inducing factor, as well as facilitate cell apoptosis after treatment of culture without FBS.	tet	40-52	BCL2 apoptosis regulator	Homo sapiens	88-93
11960373-4	2002	Expression of EWS-WT1 from a tetracycline-regulated promoter leads to the induction of growth-associated genes, of which the most remarkable is the beta-chain of the interleukin-2/15 receptor (IL-2/15Rbeta).	tet	29-41	WT1 transcription factor	Homo sapiens	14-21
11960373-4	2002	Expression of EWS-WT1 from a tetracycline-regulated promoter leads to the induction of growth-associated genes, of which the most remarkable is the beta-chain of the interleukin-2/15 receptor (IL-2/15Rbeta).	tet	29-41	interleukin 2	Homo sapiens	193-197
11875015-13	2002	Finally, the generation of tetracycline-repressed t-PA transfectants in PANC-1 cells confirmed the activity of t-PA in invasion and proliferation in vitro and in vivo.	tet	27-39	plasminogen activator, tissue type	Homo sapiens	50-54
11875015-13	2002	Finally, the generation of tetracycline-repressed t-PA transfectants in PANC-1 cells confirmed the activity of t-PA in invasion and proliferation in vitro and in vivo.	tet	27-39	plasminogen activator, tissue type	Homo sapiens	111-115
11949850-0	2002	Rapid determination of tetracycline in milk by FT-MIR and FT-NIR spectroscopy.	tet	23-35	membrane associated ring-CH-type finger 8	Homo sapiens	50-53
11949850-2	2002	Milk samples spiked with different concentrations of tetracycline were scanned using FT-MIR and FT-NIR spectroscopy.	tet	53-65	membrane associated ring-CH-type finger 8	Homo sapiens	88-91
11949850-7	2002	Results indicated that FT-MIR spectroscopy could be used for rapid detection of tetracycline hydrochloride residues in milk.	tet	80-106	membrane associated ring-CH-type finger 8	Homo sapiens	26-29
11953454-2	2002	To study the specific role of caspase-3 activation in neuronal cells, we generated a stable tetracycline-regulated SK-N-MC neuroblastoma cell line, which expressed a highly efficient self-activating chimeric caspase-3, consisting of the caspase-1 prodomain fused to the caspase-3 catalytic domain.	tet	92-104	caspase 3	Homo sapiens	208-217
11953454-2	2002	To study the specific role of caspase-3 activation in neuronal cells, we generated a stable tetracycline-regulated SK-N-MC neuroblastoma cell line, which expressed a highly efficient self-activating chimeric caspase-3, consisting of the caspase-1 prodomain fused to the caspase-3 catalytic domain.	tet	92-104	caspase 1	Homo sapiens	237-246
11953454-2	2002	To study the specific role of caspase-3 activation in neuronal cells, we generated a stable tetracycline-regulated SK-N-MC neuroblastoma cell line, which expressed a highly efficient self-activating chimeric caspase-3, consisting of the caspase-1 prodomain fused to the caspase-3 catalytic domain.	tet	92-104	caspase 3	Homo sapiens	208-217
11750938-3	2002	First, a stable cell line, R-C535C, expressing a high level of UL9-C535C in the presence of tetracycline and little or no UL9-C535C in the absence of tetracycline was established.	tet	92-104	DNA replication origin-binding helicase	Human alphaherpesvirus 1	63-66
11919711-10	2002	However, tetracycline-dependent expression of a VP16-BZI-1 protein in tobacco plants did not result in activation of CHS or PAL.	tet	9-21	light-inducible protein CPRF2-like	Nicotiana tabacum	53-58
11750938-4	2002	The single step growth experiment showed that like HSV-1, the de novo synthesis of HSV-2 could be suppressed approximately 1000-fold by UL9-C535C expressed in R-C535C cells in the presence of tetracycline.	tet	192-204	involved in DNA replication	Human alphaherpesvirus 2	136-139
11772948-2	2002	In this paper we describe two novel human cell lines that are capable of expressing high levels of iNOS under the control of analogues of either the insect hormone ecdysone or tetracycline.	tet	176-188	nitric oxide synthase 2	Homo sapiens	99-103
11903975-4	2002	Wisconsin-38) containing the oat ADC cDNA under the control of a tetracycline inducible promoter, the severity of which was correlated with Put content.	tet	65-77	arginine decarboxylase	Nicotiana tabacum	33-36
12028300-4	2002	METHODS: We synthesized antisense OPN expression vector (pTet-OPNas) using the tetracycline-regulated expression system.	tet	79-91	secreted phosphoprotein 1	Rattus norvegicus	34-37
11809863-9	2002	The induction of Egr-1 in rat neonatal ventricular myocytes with phorbol-12-myristate-13-acetate or in HeLa S3 cells by regulated expression of Egr-1 in a tetracycline-responsive promoter, suppressed expression from the beta(1)-AR promoter.	tet	155-167	early growth response 1	Rattus norvegicus	17-22
11809863-9	2002	The induction of Egr-1 in rat neonatal ventricular myocytes with phorbol-12-myristate-13-acetate or in HeLa S3 cells by regulated expression of Egr-1 in a tetracycline-responsive promoter, suppressed expression from the beta(1)-AR promoter.	tet	155-167	early growth response 1	Homo sapiens	144-149
11809863-9	2002	The induction of Egr-1 in rat neonatal ventricular myocytes with phorbol-12-myristate-13-acetate or in HeLa S3 cells by regulated expression of Egr-1 in a tetracycline-responsive promoter, suppressed expression from the beta(1)-AR promoter.	tet	155-167	adrenoceptor beta 1	Homo sapiens	220-230
11812277-7	2002	Moreover, a stringent control of mEpo gene expression and Hct levels in the absence of any background activity was maintained over a 10-month period by injecting as little as 1 microg of a single plasmid containing the rtTA2(S)-S2 expression cassette and the Tet-responsive mEpo cDNA.	tet	259-262	erythropoietin	Mus musculus	33-37
11812288-0	2002	Tightly regulated long-term erythropoietin expression in vivo using tet-inducible recombinant adeno-associated viral vectors.	tet	68-71	erythropoietin	Homo sapiens	28-42
11846446-4	2002	To study the mechanisms of these effects, a tetracycline-inducible expression system was used to overexpress type II TGF-beta receptors in NIH 3T3 fibroblasts.	tet	44-56	transforming growth factor beta 1	Homo sapiens	117-125
11779176-4	2002	TGF-alpha expression was inhibited by the presence of tetracycline, and subcutaneous tumors forming from cell lines injected into nude mice could be inhibited by feeding mice tetracycline.	tet	54-66	transforming growth factor alpha	Mus musculus	0-9
11779176-4	2002	TGF-alpha expression was inhibited by the presence of tetracycline, and subcutaneous tumors forming from cell lines injected into nude mice could be inhibited by feeding mice tetracycline.	tet	175-187	transforming growth factor alpha	Mus musculus	0-9
11908634-9	2002	In addition, when recombinant human lactoferrin was used in combination with low doses of amoxicillin or tetracycline, there was an enhancement in gastritis-reducing activity.	tet	105-117	lactotransferrin	Bos taurus	36-47
11855680-3	2002	The apparent Km values for hOAT2-, hOAT3- and hOAT4-mediated tetracycline uptakes were 439.9 +/- 23.0, 566.2 +/- 28.4 and 122.7 +/- 16.0 microM, respectively.	tet	61-73	solute carrier family 22 member 7	Homo sapiens	27-32
11855680-3	2002	The apparent Km values for hOAT2-, hOAT3- and hOAT4-mediated tetracycline uptakes were 439.9 +/- 23.0, 566.2 +/- 28.4 and 122.7 +/- 16.0 microM, respectively.	tet	61-73	solute carrier family 22 member 8	Homo sapiens	35-40
11855680-3	2002	The apparent Km values for hOAT2-, hOAT3- and hOAT4-mediated tetracycline uptakes were 439.9 +/- 23.0, 566.2 +/- 28.4 and 122.7 +/- 16.0 microM, respectively.	tet	61-73	solute carrier family 22 member 11	Homo sapiens	46-51
11855680-4	2002	Tetracycline significantly inhibited the organic anion uptake by hOAT1, hOAT2 and hOAT4, but not hOAT3.	tet	0-12	solute carrier family 22 member 6	Homo sapiens	65-70
11855680-4	2002	Tetracycline significantly inhibited the organic anion uptake by hOAT1, hOAT2 and hOAT4, but not hOAT3.	tet	0-12	solute carrier family 22 member 7	Homo sapiens	72-77
11855680-4	2002	Tetracycline significantly inhibited the organic anion uptake by hOAT1, hOAT2 and hOAT4, but not hOAT3.	tet	0-12	solute carrier family 22 member 11	Homo sapiens	82-87
11767279-6	2001	We demonstrate that infection with a recombinant TGF-beta-encoding virus system in primary human oral keratinocytes and in a lung epithelial cell line is sufficient to allow a cell cycle arrest that is reversible upon tetracycline addition.	tet	218-230	transforming growth factor beta 1	Homo sapiens	49-57
11855680-7	2002	HOAT1 and hOAT4 mediated the efflux of tetracycline, but hOAT2 and hOAT3 did not.	tet	39-51	solute carrier family 22 member 6	Homo sapiens	0-5
11855680-7	2002	HOAT1 and hOAT4 mediated the efflux of tetracycline, but hOAT2 and hOAT3 did not.	tet	39-51	solute carrier family 22 member 11	Homo sapiens	10-15
11855680-8	2002	These results suggest that hOAT1, hOAT2 and hOAT3 mediate the basolateral uptake and/or efflux of tetracycline, whereas hOAT4 is responsible for the reabsorption as well as the efflux of tetracycline in the apical side of the proximal tubule.	tet	98-110	solute carrier family 22 member 6	Homo sapiens	27-32
11855680-8	2002	These results suggest that hOAT1, hOAT2 and hOAT3 mediate the basolateral uptake and/or efflux of tetracycline, whereas hOAT4 is responsible for the reabsorption as well as the efflux of tetracycline in the apical side of the proximal tubule.	tet	98-110	solute carrier family 22 member 7	Homo sapiens	34-39
11855680-8	2002	These results suggest that hOAT1, hOAT2 and hOAT3 mediate the basolateral uptake and/or efflux of tetracycline, whereas hOAT4 is responsible for the reabsorption as well as the efflux of tetracycline in the apical side of the proximal tubule.	tet	98-110	solute carrier family 22 member 8	Homo sapiens	44-49
11855680-8	2002	These results suggest that hOAT1, hOAT2 and hOAT3 mediate the basolateral uptake and/or efflux of tetracycline, whereas hOAT4 is responsible for the reabsorption as well as the efflux of tetracycline in the apical side of the proximal tubule.	tet	187-199	solute carrier family 22 member 6	Homo sapiens	27-32
11855680-8	2002	These results suggest that hOAT1, hOAT2 and hOAT3 mediate the basolateral uptake and/or efflux of tetracycline, whereas hOAT4 is responsible for the reabsorption as well as the efflux of tetracycline in the apical side of the proximal tubule.	tet	187-199	solute carrier family 22 member 8	Homo sapiens	44-49
11855680-8	2002	These results suggest that hOAT1, hOAT2 and hOAT3 mediate the basolateral uptake and/or efflux of tetracycline, whereas hOAT4 is responsible for the reabsorption as well as the efflux of tetracycline in the apical side of the proximal tubule.	tet	187-199	solute carrier family 22 member 11	Homo sapiens	120-125
11739413-3	2001	Animals carrying both mouse mammary tumor virus (MMTV)-reverse tetracycline transactivator and tetracycline response element (TRE)2-Axin-green fluorescent protein (GFP) transgenes exhibited Dox-dependent Axin expression and, when induced from birth, displayed abnormalities in the development of mammary glands and lymphoid tissues, both sites in which the MMTV promoter is active.	tet	63-75	axin 1	Mus musculus	204-208
11739413-3	2001	Animals carrying both mouse mammary tumor virus (MMTV)-reverse tetracycline transactivator and tetracycline response element (TRE)2-Axin-green fluorescent protein (GFP) transgenes exhibited Dox-dependent Axin expression and, when induced from birth, displayed abnormalities in the development of mammary glands and lymphoid tissues, both sites in which the MMTV promoter is active.	tet	95-107	axin 1	Mus musculus	132-136
11739413-3	2001	Animals carrying both mouse mammary tumor virus (MMTV)-reverse tetracycline transactivator and tetracycline response element (TRE)2-Axin-green fluorescent protein (GFP) transgenes exhibited Dox-dependent Axin expression and, when induced from birth, displayed abnormalities in the development of mammary glands and lymphoid tissues, both sites in which the MMTV promoter is active.	tet	95-107	axin 1	Mus musculus	204-208
11719367-5	2001	The transgenic mouse model, referred to as tetO-HOXA10, contains the H0XA10 gene controlled by a tetracycline-responsive element and a minimal promoter.	tet	97-109	homeobox A10	Mus musculus	48-54
11760850-8	2001	During culture, inclusion of the tetracycline-derived, collagenase/gelatinase inhibitor chemically modified nonantimicrobial tetracycline (CMT-8) at concentrations specific for MMP-13 inhibition resulted in complete inhibition of TGF-beta activation by proliferating and hypertrophic chondrocytes.	tet	33-45	matrix metallopeptidase 13	Gallus gallus	177-183
11760850-8	2001	During culture, inclusion of the tetracycline-derived, collagenase/gelatinase inhibitor chemically modified nonantimicrobial tetracycline (CMT-8) at concentrations specific for MMP-13 inhibition resulted in complete inhibition of TGF-beta activation by proliferating and hypertrophic chondrocytes.	tet	125-137	matrix metallopeptidase 13	Gallus gallus	177-183
11735344-6	2001	A dual adenovirus tetracycline-regulatable expression system was generated to control the production of TH.	tet	18-30	tyrosine hydroxylase	Rattus norvegicus	104-106
11572858-2	2001	We have previously established a genetic system based on the chicken pre-B cell line DT40, in which expression of SMN protein is regulated by tetracycline, to study the function of SMN in vivo.	tet	142-154	survival of motor neuron	Gallus gallus	114-117
11581265-4	2001	This chimeric repressor was engineered by fusing the tetracycline repressor (TetR) with an mSin3-interacting domain of human Mad1 and was shown to bind the tetO(2) element with high affinity, and its binding was efficiently abrogated by doxycycline.	tet	53-65	transcriptional regulator, SIN3A (yeast)	Mus musculus	91-96
11579088-8	2001	The PON2 protein was overexpressed in HeLa cells using the tetracycline-inducible ("Tet-On") system, and its antioxidant capacity was measured in a fluorometric assay.	tet	59-71	paraoxonase 2	Homo sapiens	4-8
11581265-4	2001	This chimeric repressor was engineered by fusing the tetracycline repressor (TetR) with an mSin3-interacting domain of human Mad1 and was shown to bind the tetO(2) element with high affinity, and its binding was efficiently abrogated by doxycycline.	tet	53-65	MAX dimerization protein 1	Homo sapiens	125-129
11673863-6	2001	In this study, we used the tetracycline-regulated (tet) promoter system to increase the expression of the human CYP1B1 (hCYP1B1) gene in the tissues of transgenic mice.	tet	27-39	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	112-118
11731004-6	2001	Because this fragment is normally present at levels that are difficult to detect, we have used cell lines in which the production of wild-type or N141I mutant PS2 is controlled by a tetracycline-regulated promoter in order to assess the subcellular localization of the caspase CTF in relation to the larger, constitutive PS2 CTF and to PS2 holoprotein.	tet	182-194	presenilin 2	Homo sapiens	159-162
11697891-3	2001	Tetracycline-regulated ADAM15 overexpression in NIH3T3 cells leads to an inhibition of migration on a fibronectin-coated filter in a Boyden chamber assay and in a scratch wound model.	tet	0-12	a disintegrin and metallopeptidase domain 15 (metargidin)	Mus musculus	23-29
11697891-3	2001	Tetracycline-regulated ADAM15 overexpression in NIH3T3 cells leads to an inhibition of migration on a fibronectin-coated filter in a Boyden chamber assay and in a scratch wound model.	tet	0-12	fibronectin 1	Mus musculus	102-113
11673863-6	2001	In this study, we used the tetracycline-regulated (tet) promoter system to increase the expression of the human CYP1B1 (hCYP1B1) gene in the tissues of transgenic mice.	tet	27-39	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	120-127
11709053-5	2001	In the current study we have generated cell lines with tetracycline-regulated, inducible expression of BRCA1 as a tool to identify genes, which might represent important effectors of BRCA1 function.	tet	55-67	BRCA1 DNA repair associated	Homo sapiens	103-108
11709053-5	2001	In the current study we have generated cell lines with tetracycline-regulated, inducible expression of BRCA1 as a tool to identify genes, which might represent important effectors of BRCA1 function.	tet	55-67	BRCA1 DNA repair associated	Homo sapiens	183-188
11705873-2	2001	To study the importance of TS expression in determining resistance to these agents, we have developed an MDA435 breast cancer-derived cell line with tetracycline-regulated expression of TS termed MTS-5.	tet	149-161	thymidylate synthetase	Homo sapiens	186-188
11705873-2	2001	To study the importance of TS expression in determining resistance to these agents, we have developed an MDA435 breast cancer-derived cell line with tetracycline-regulated expression of TS termed MTS-5.	tet	149-161	thymidylate synthetase	Homo sapiens	27-29
11640884-2	2001	To further explore the role of filaggrin in the cytoskeletal rearrangement that accompanies epidermal differentiation, we generated keratinocyte cell lines that express human filaggrin using a tetracycline-inducible promoter system.	tet	193-205	filaggrin	Homo sapiens	31-40
11640884-2	2001	To further explore the role of filaggrin in the cytoskeletal rearrangement that accompanies epidermal differentiation, we generated keratinocyte cell lines that express human filaggrin using a tetracycline-inducible promoter system.	tet	193-205	filaggrin	Homo sapiens	175-184
11892838-2	2001	We therefore used a p53-null human NSCLC cell line in which we reintroduced the wild-type p53 gene under control of a tetracycline-dependent promoter.	tet	118-130	tumor protein p53	Homo sapiens	20-23
11892838-2	2001	We therefore used a p53-null human NSCLC cell line in which we reintroduced the wild-type p53 gene under control of a tetracycline-dependent promoter.	tet	118-130	tumor protein p53	Homo sapiens	90-93
11708878-0	2001	A complex adenovirus vector that delivers FASL-GFP with combined prostate-specific and tetracycline-regulated expression.	tet	87-99	Fas ligand (TNF superfamily, member 6)	Mus musculus	42-46
11735369-7	2001	Antibodies to two of the proteins encoded in this region (TraG and TraN) were obtained and used to show that production of these proteins was dependent on tetracycline stimulation.	tet	155-167	WD repeat domain 7	Homo sapiens	58-62
11735369-7	2001	Antibodies to two of the proteins encoded in this region (TraG and TraN) were obtained and used to show that production of these proteins was dependent on tetracycline stimulation.	tet	155-167	tRNA-Ala (anticodon TGC) 7-1	Homo sapiens	67-71
11735369-11	2001	If so, TraQ is not the only protein that controls expression of transfer genes because production of TraG and TraN in the traQ disruption mutant was still dependent on tetracycline stimulation.	tet	168-180	tRNA-Ala (anticodon TGC) 7-1	Homo sapiens	110-114
11597769-0	2001	Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression.	tet	67-79	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	90-93
11597769-4	2001	We therefore employed the forebrain specific alphaCaMKII promoter to drive tTA-mediated tetracycline sensitive transcription of transgenes for NR1(R) and for lacZ as reporter.	tet	88-100	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	143-146
11489880-2	2001	In the present study, we investigated this cell death pathway by stably transfecting the p53-null H358 cell line with a tetracycline-dependent wild type p53-expressing vector.	tet	120-132	tumor protein p53	Homo sapiens	89-92
11489880-2	2001	In the present study, we investigated this cell death pathway by stably transfecting the p53-null H358 cell line with a tetracycline-dependent wild type p53-expressing vector.	tet	120-132	tumor protein p53	Homo sapiens	153-156
11489880-4	2001	Accordingly, overexpression of BAX in H358 cells, through stable transfection of a tetracycline-regulated expression vector, did not induce cell death.	tet	83-95	BCL2 associated X, apoptosis regulator	Homo sapiens	31-34
11602356-3	2001	beta-Galactosidase could be induced over 300 fold with this system, and the extent of induction could be varied depending upon the amount of tetracycline added.	tet	141-153	galactosidase beta 1	Homo sapiens	0-18
11767279-0	2001	An adenoviral system for tetracycline-regulated TGF-beta expression mediates a reversible cell cycle arrest.	tet	25-37	transforming growth factor beta 1	Homo sapiens	48-56
11767279-5	2001	We have adapted the tetracycline-regulated expression system to allow regulated transforming growth factor (TGF)-beta1 expression using recombinant adenovirus.	tet	20-32	transforming growth factor beta 1	Homo sapiens	80-118
11795468-3	2001	In this study, we developed a tetracycline-regulated gene expression system to determine the specific effects of inducible Hsp70 on cell growth and protection against hyperthermia in MCF-7 breast cancer cells.	tet	30-42	heat shock protein family A (Hsp70) member 4	Homo sapiens	123-128
11747877-4	2001	Ormeloxifene administered per se inhibited aminopyrine-N-demethylase (AD), glucose-6-phosphate dehydrogenase (G-6-PDH) and glutathione-S-transferase (GST) in the liver on the day of maximal endometrial receptivity, which was prevented by tetracycline co-administration.	tet	238-250	hematopoietic prostaglandin D synthase	Rattus norvegicus	150-153
11587226-3	2001	To generate a tetracycline-inducible BCR-ABL retrovirus, we have subcloned BCR-ABL p210 cDNA in the SIN-Retro-TET vector, which allows regulated expression of a gene of interest in a single autoregulatory cassette, containing both tTA and Tet OP sequences.	tet	14-26	envoplakin	Mus musculus	83-87
11572981-3	2001	We have transfected FAK-null fibroblasts with FAK gene under the control of the tetracycline repression system.	tet	80-92	protein tyrosine kinase 2	Homo sapiens	20-23
11572981-3	2001	We have transfected FAK-null fibroblasts with FAK gene under the control of the tetracycline repression system.	tet	80-92	protein tyrosine kinase 2	Homo sapiens	46-49
11590121-5	2001	Furthermore, using tetracycline regulation, we somatically induced human GAA in the knockout mice, and demonstrated that the skeletal and cardiac muscle pathology was completely reversible if the treatment was begun early.	tet	19-31	alpha glucosidase	Homo sapiens	73-76
11461911-9	2001	Furthermore, tetracycline-regulated, pX-NLS-expressing cell lines demonstrate that expression of the nuclear pX-NLS variant minimally activates the RAS-RAF-MAPK pathway and results in markedly reduced transformation.	tet	13-25	zinc fingers and homeoboxes 2	Homo sapiens	152-155
11536301-4	2001	METHODS: A conditional eukaryotic expression vector (under tetracycline regulation) expressing antisense p53 cDNA was constructed and either directly transfected into LNCaP cells or tranduced into these cells using recombinant retroviruses containing the vector.	tet	59-71	tumor protein p53	Homo sapiens	105-108
11593387-3	2001	Here, we report that p63, like p53 and p73, induces replicative senescence when expressed in a tetracycline-regulated manner in EJ cells lacking a functional p53.	tet	95-107	tumor protein p63	Homo sapiens	21-24
11593387-3	2001	Here, we report that p63, like p53 and p73, induces replicative senescence when expressed in a tetracycline-regulated manner in EJ cells lacking a functional p53.	tet	95-107	tumor protein p53	Homo sapiens	31-34
11593387-3	2001	Here, we report that p63, like p53 and p73, induces replicative senescence when expressed in a tetracycline-regulated manner in EJ cells lacking a functional p53.	tet	95-107	tumor protein p73	Homo sapiens	39-42
11375983-3	2001	When ectopic wild-type p53 expression was induced to a physiologically relevant level in "tet-off" cultured cells in which p53 expression was tightly regulated by tetracycline, it was found that POLD1 steady-state mRNA was repressed by about 65%.	tet	163-175	tumor protein p53	Homo sapiens	23-26
12549222-5	2001	We further showed that telomerase activation in infected cells was dependent on the protein level of latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus using a Tetracycline regulatory cell line expressing LMP1, pTet-on-LMP1-HNE2.	tet	172-184	PDZ and LIM domain 7	Homo sapiens	128-132
11375983-3	2001	When ectopic wild-type p53 expression was induced to a physiologically relevant level in "tet-off" cultured cells in which p53 expression was tightly regulated by tetracycline, it was found that POLD1 steady-state mRNA was repressed by about 65%.	tet	163-175	tumor protein p53	Homo sapiens	123-126
11375983-3	2001	When ectopic wild-type p53 expression was induced to a physiologically relevant level in "tet-off" cultured cells in which p53 expression was tightly regulated by tetracycline, it was found that POLD1 steady-state mRNA was repressed by about 65%.	tet	163-175	DNA polymerase delta 1, catalytic subunit	Homo sapiens	195-200
11499754-5	2001	METHODS: In the present study, the gene coding for rabbit TFPI was inserted in a retroviral vector under control of a tetracycline-inducible promoter.	tet	118-130	tissue factor pathway inhibitor	Oryctolagus cuniculus	58-62
11463839-2	2001	To investigate the impact of AML1-ETO on hematopoiesis, tetracycline-inducible AML1-ETO-expressing cell lines were generated using myeloid cells.	tet	56-68	RUNX family transcription factor 1	Homo sapiens	79-83
11469893-3	2001	We hypothesized that a chemically modified tetracycline 3 (COL-3), a potent inhibitor of neutrophil matrix metalloproteinases (MMPs) and neutrophil elastase (NE) with minimal toxicity, would prevent ARDS in our porcine endotoxin-induced ARDS model.	tet	43-55	matrix metallopeptidase 2	Homo sapiens	127-131
11469893-3	2001	We hypothesized that a chemically modified tetracycline 3 (COL-3), a potent inhibitor of neutrophil matrix metalloproteinases (MMPs) and neutrophil elastase (NE) with minimal toxicity, would prevent ARDS in our porcine endotoxin-induced ARDS model.	tet	43-55	elastase, neutrophil expressed	Homo sapiens	137-156
11463839-2	2001	To investigate the impact of AML1-ETO on hematopoiesis, tetracycline-inducible AML1-ETO-expressing cell lines were generated using myeloid cells.	tet	56-68	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	84-87
11463839-3	2001	AML1-ETO is tightly and strongly induced upon tetracycline withdrawal.	tet	46-58	RUNX family transcription factor 1	Homo sapiens	0-4
11463839-3	2001	AML1-ETO is tightly and strongly induced upon tetracycline withdrawal.	tet	46-58	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	5-8
11819829-0	2001	Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87.	tet	69-81	TNF superfamily member 10	Homo sapiens	18-55
11551864-3	2001	To explore the actions of cardiac HSL, heart-specific, tetracycline (Tc)-controlled HSL-overexpressing mice were generated.	tet	55-67	lipase, hormone sensitive	Mus musculus	84-87
11551864-3	2001	To explore the actions of cardiac HSL, heart-specific, tetracycline (Tc)-controlled HSL-overexpressing mice were generated.	tet	69-71	lipase, hormone sensitive	Mus musculus	84-87
11551864-4	2001	Tc-responsive element-HSL transgenic (Tg) mice were generated and crossed with myosin heavy chain (MHC)alpha-tTA Tg mice, which express the Tc-responsive transactivator (tTA) in the heart.	tet	0-2	lipase, hormone sensitive	Mus musculus	22-25
11819829-1	2001	AIM: To clone the cDNA fragment of human TRAIL (TNF-related apoptosis inducing ligand) into a tetracycline-regulated gene expression system, the RevTet-On system, transduce expression vectors into a gastric carcinoma cell line-NCI-N87 and examine the effects of controlled expression of TRAIL in vitro on the gastric carcinoma cells.	tet	94-106	TNF superfamily member 10	Homo sapiens	41-46
11819829-1	2001	AIM: To clone the cDNA fragment of human TRAIL (TNF-related apoptosis inducing ligand) into a tetracycline-regulated gene expression system, the RevTet-On system, transduce expression vectors into a gastric carcinoma cell line-NCI-N87 and examine the effects of controlled expression of TRAIL in vitro on the gastric carcinoma cells.	tet	94-106	TNF superfamily member 10	Homo sapiens	48-85
11819829-2	2001	METHODS: The full-length cDNA of TRAIL was inserted into a vector under the control of the tetracycline-responsive element (TRE) to obtain the plasmid pRevTRE-TRAIL, which was transfected into a packaging cell line PT67.	tet	91-103	TNF superfamily member 10	Homo sapiens	33-38
11819829-2	2001	METHODS: The full-length cDNA of TRAIL was inserted into a vector under the control of the tetracycline-responsive element (TRE) to obtain the plasmid pRevTRE-TRAIL, which was transfected into a packaging cell line PT67.	tet	91-103	TNF superfamily member 10	Homo sapiens	159-164
11819829-7	2001	TRAIL expression in the cell line was induced by incubating cells with doxycycline (Dox), which is a tetracycline analogue.	tet	101-113	TNF superfamily member 10	Homo sapiens	0-5
11331289-5	2001	Human bladder carcinoma cells mutant for p53 and containing a tetracycline-regulated p21 cDNA showed no significant enhancement of repair upon induction of p21 expression.	tet	62-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	85-88
11481479-1	2001	To study the role of transforming growth factor type beta1 (TGFbeta1) in epidermal growth control and disease, we have generated a conditional expression system by using the bovine keratin 5 promoter to drive expression of the tetracycline-regulated transactivators tTA and rTA, and a constitutively active mutant of TGFbeta1 linked to the tetO target sequence for the transactivator.	tet	227-239	transforming growth factor beta 1	Bos taurus	21-58
11481479-1	2001	To study the role of transforming growth factor type beta1 (TGFbeta1) in epidermal growth control and disease, we have generated a conditional expression system by using the bovine keratin 5 promoter to drive expression of the tetracycline-regulated transactivators tTA and rTA, and a constitutively active mutant of TGFbeta1 linked to the tetO target sequence for the transactivator.	tet	227-239	transforming growth factor beta 1	Bos taurus	60-68
11481479-1	2001	To study the role of transforming growth factor type beta1 (TGFbeta1) in epidermal growth control and disease, we have generated a conditional expression system by using the bovine keratin 5 promoter to drive expression of the tetracycline-regulated transactivators tTA and rTA, and a constitutively active mutant of TGFbeta1 linked to the tetO target sequence for the transactivator.	tet	227-239	RT1 class I, locus A	Rattus norvegicus	274-277
11481479-1	2001	To study the role of transforming growth factor type beta1 (TGFbeta1) in epidermal growth control and disease, we have generated a conditional expression system by using the bovine keratin 5 promoter to drive expression of the tetracycline-regulated transactivators tTA and rTA, and a constitutively active mutant of TGFbeta1 linked to the tetO target sequence for the transactivator.	tet	227-239	transforming growth factor beta 1	Bos taurus	317-325
11453638-3	2001	Both genes were put under the control of the tetracycline-responsive promoter, allowing tight regulation of PrP expression.	tet	45-57	prion protein	Homo sapiens	108-111
11780335-2	2001	METHODS: A tetracycline-regulated LMP1-expressing nasopharyngeal carcinoma cell line, Tet-on-LMP1-HNE2, was used as the cell model.	tet	11-23	PDZ and LIM domain 7	Homo sapiens	34-38
11464512-2	2001	To achieve this, we generated stable cell lines that express the modified tetracycline repressor molecule (rtTA) and the beta-gal gene under control of tetracycline-responsive cis-elements.	tet	152-164	galactosidase beta 1	Homo sapiens	121-129
11464512-3	2001	The resulting cell lines express functional beta-gal following treatment with the tetracycline analog doxycyclin (Dox).	tet	82-94	galactosidase beta 1	Homo sapiens	44-52
11780335-2	2001	METHODS: A tetracycline-regulated LMP1-expressing nasopharyngeal carcinoma cell line, Tet-on-LMP1-HNE2, was used as the cell model.	tet	11-23	PDZ and LIM domain 7	Homo sapiens	93-97
11526595-3	2001	A tetracycline-regulated promoter was developed to drive Bcr-Abl expression in differentiating embryonal stem cells.	tet	2-14	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	57-64
11452006-5	2001	A tetracycline-inducible mutant Rab9S21N HeLa cell line was constructed and characterized to study whether Rab9 was involved in transport of ricin to the TGN and, if not, to further investigate the route used by ricin.	tet	2-14	RAB9A, member RAS oncogene family	Homo sapiens	32-36
11439332-3	2001	Here, we applied the human p27 gene as a novel anticancer agent for HER2/neu-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	121-133	interferon alpha inducible protein 27	Homo sapiens	27-30
11434920-2	2001	We established osteosarcoma cell lines in which a tetracycline-regulatable promoter controls the induction of RB, p53 and p21.	tet	50-62	tumor protein p53	Homo sapiens	114-117
11434920-2	2001	We established osteosarcoma cell lines in which a tetracycline-regulatable promoter controls the induction of RB, p53 and p21.	tet	50-62	cyclin dependent kinase inhibitor 1A	Homo sapiens	122-125
11439332-3	2001	Here, we applied the human p27 gene as a novel anticancer agent for HER2/neu-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	121-133	erb-b2 receptor tyrosine kinase 2	Homo sapiens	68-72
11439332-3	2001	Here, we applied the human p27 gene as a novel anticancer agent for HER2/neu-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	121-133	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-76
11439332-3	2001	Here, we applied the human p27 gene as a novel anticancer agent for HER2/neu-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	121-124	interferon alpha inducible protein 27	Homo sapiens	27-30
11439332-3	2001	Here, we applied the human p27 gene as a novel anticancer agent for HER2/neu-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	121-124	erb-b2 receptor tyrosine kinase 2	Homo sapiens	68-72
11439332-3	2001	Here, we applied the human p27 gene as a novel anticancer agent for HER2/neu-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	121-124	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-76
11390446-2	2001	In a transgenic model (rat insulin promoter-lymphocytic choriomeningitis virus) of virally induced diabetes, TNF-alpha enhanced disease incidence when induced through an islet-specific tetracycline-dependent promoter system early during pathogenesis.	tet	185-197	tumor necrosis factor	Homo sapiens	109-118
11514615-5	2001	We used Madin-Darby canine kidney cells that expressed dominant-active or dominant-negative mutants of Cdc42 under the control of a tetracycline-repressible system.	tet	132-144	cell division control protein 42 homolog	Canis lupus familiaris	103-108
11279197-5	2001	Increased expression of the C-terminal JNK fragment in a tetracycline-inducible transfected NIH3T3 cell line produced a concentration-dependent increase in the kinase activity of JNK under normal, unstressed growth conditions indicating a dominant-negative effect.	tet	57-69	mitogen-activated protein kinase 8	Mus musculus	39-42
11279197-5	2001	Increased expression of the C-terminal JNK fragment in a tetracycline-inducible transfected NIH3T3 cell line produced a concentration-dependent increase in the kinase activity of JNK under normal, unstressed growth conditions indicating a dominant-negative effect.	tet	57-69	mitogen-activated protein kinase 8	Mus musculus	179-182
11389016-6	2001	Controlled secretion of dimeric erythropoietin was achieved in beta-thalassemic mice by in vivo intramuscular electrotransfer of a mouse Epo-Epo plasmid containing the tetO element and of a plasmid encoding the tetracycline controlled transactivator tTA.	tet	211-223	erythropoietin	Mus musculus	32-46
11389016-8	2001	On tetracycline withdrawal, expression of the Epo-Epo dimer resumed, thereby resulting in a large and sustained hematocrit increase in beta-thalassemic mice.	tet	3-15	erythropoietin	Mus musculus	46-49
11389016-8	2001	On tetracycline withdrawal, expression of the Epo-Epo dimer resumed, thereby resulting in a large and sustained hematocrit increase in beta-thalassemic mice.	tet	3-15	erythropoietin	Mus musculus	50-53
11380466-6	2001	In p15- and p16-null K562 cells transfected with a tetracycline-inducible p15 cDNA construct, induction of p15 transcripts and protein was accompanied by decreased growth rates, decreased S-phase fraction, decreased retinoblastoma protein phosphorylation, and markedly reduced levels of DHFR transcripts and protein.	tet	51-63	cyclin dependent kinase inhibitor 2B	Homo sapiens	3-6
11356380-0	2001	A tetracycline-repressible transactivator approach suggests a shorter half-life for tyrosine hydroxylase mRNA.	tet	2-14	tyrosine hydroxylase	Rattus norvegicus	84-104
11356380-5	2001	In this study the regulation of the expression of the rat TH gene was placed under the control of a tetracycline (Tet)-repressible transactivator (tTA).	tet	100-112	tyrosine hydroxylase	Rattus norvegicus	58-60
11356380-5	2001	In this study the regulation of the expression of the rat TH gene was placed under the control of a tetracycline (Tet)-repressible transactivator (tTA).	tet	114-117	tyrosine hydroxylase	Rattus norvegicus	58-60
11356380-6	2001	In the absence of doxycycline (Dox), an analogue of Tet, TH mRNA was synthesized.	tet	52-55	tyrosine hydroxylase	Rattus norvegicus	57-59
11356380-9	2001	This effect was not due to some unique feature of the chimeric gene used to synthesize TH mRNA or to an untoward effect of the Tet analogue used to suppress TH transcription.	tet	127-130	tyrosine hydroxylase	Rattus norvegicus	157-159
11380466-6	2001	In p15- and p16-null K562 cells transfected with a tetracycline-inducible p15 cDNA construct, induction of p15 transcripts and protein was accompanied by decreased growth rates, decreased S-phase fraction, decreased retinoblastoma protein phosphorylation, and markedly reduced levels of DHFR transcripts and protein.	tet	51-63	cyclin dependent kinase inhibitor 2A	Homo sapiens	12-15
11380466-6	2001	In p15- and p16-null K562 cells transfected with a tetracycline-inducible p15 cDNA construct, induction of p15 transcripts and protein was accompanied by decreased growth rates, decreased S-phase fraction, decreased retinoblastoma protein phosphorylation, and markedly reduced levels of DHFR transcripts and protein.	tet	51-63	cyclin dependent kinase inhibitor 2B	Homo sapiens	74-77
11380466-6	2001	In p15- and p16-null K562 cells transfected with a tetracycline-inducible p15 cDNA construct, induction of p15 transcripts and protein was accompanied by decreased growth rates, decreased S-phase fraction, decreased retinoblastoma protein phosphorylation, and markedly reduced levels of DHFR transcripts and protein.	tet	51-63	cyclin dependent kinase inhibitor 2B	Homo sapiens	74-77
11380466-6	2001	In p15- and p16-null K562 cells transfected with a tetracycline-inducible p15 cDNA construct, induction of p15 transcripts and protein was accompanied by decreased growth rates, decreased S-phase fraction, decreased retinoblastoma protein phosphorylation, and markedly reduced levels of DHFR transcripts and protein.	tet	51-63	dihydrofolate reductase	Homo sapiens	287-291
11356701-4	2001	To achieve regulatable transgene expression within predetermined AP cells, the tetracycline-responsive transcriptional elements have been engineered to be under the control of human, lactotroph-specific PRL (hPRL) promoter elements within a dual adenoviral vector system.	tet	79-91	prolactin	Homo sapiens	203-206
11356701-4	2001	To achieve regulatable transgene expression within predetermined AP cells, the tetracycline-responsive transcriptional elements have been engineered to be under the control of human, lactotroph-specific PRL (hPRL) promoter elements within a dual adenoviral vector system.	tet	79-91	prolactin	Homo sapiens	208-212
11334976-6	2001	The PS1-f gene was under the control of the tetracycline-responsive transactivator.	tet	44-56	presenilin 1	Homo sapiens	4-7
11396961-3	2001	To investigate the effect of AML1/ETO in erythroid cells, we made a tetracycline-regulated AML1/ETO overexpression system in mouse erythroleukemic (MEL) cells.	tet	68-80	runt related transcription factor 1	Mus musculus	29-33
11396961-3	2001	To investigate the effect of AML1/ETO in erythroid cells, we made a tetracycline-regulated AML1/ETO overexpression system in mouse erythroleukemic (MEL) cells.	tet	68-80	runt related transcription factor 1	Mus musculus	91-95
11396961-3	2001	To investigate the effect of AML1/ETO in erythroid cells, we made a tetracycline-regulated AML1/ETO overexpression system in mouse erythroleukemic (MEL) cells.	tet	68-80	RUNX1 translocation partner 1	Mus musculus	96-99
11278282-5	2001	By using a tetracycline (tet)-regulated promoter, we found that the half-lives of these Pem introns ranged from 9 to 29 min, comparable with those of short lived mRNAs such as those encoding c-fos and c-myc.	tet	11-23	mucin 1, cell surface associated	Homo sapiens	88-91
11383749-2	2001	Minocycline, a derivative of the antibiotic tetracycline, inhibits caspase-1 expression.	tet	44-56	caspase 1	Mus musculus	67-76
11278282-5	2001	By using a tetracycline (tet)-regulated promoter, we found that the half-lives of these Pem introns ranged from 9 to 29 min, comparable with those of short lived mRNAs such as those encoding c-fos and c-myc.	tet	11-14	mucin 1, cell surface associated	Homo sapiens	88-91
11320450-5	2001	ESBL strains showed high levels of co-resistance to aminoglycosides, tetracycline, trimethoprim-sulfamethoxazole, and ciprofloxacin.	tet	69-81	EsbL	Escherichia coli	0-4
11373271-4	2001	We established tetracycline-regulated, stable hRAD50 expression systems in SaOS-2 cells, which retain mutated p53, and in HeLa cells.	tet	15-27	RAD50 double strand break repair protein	Homo sapiens	46-52
11278373-5	2001	To clarify the functional role of FKHRL1 in TPO signaling, we established a tetracycline-inducible system in the human TPO-dependent leukemia cell line UT-7/TPO.	tet	76-88	forkhead box O3	Homo sapiens	34-40
11278373-5	2001	To clarify the functional role of FKHRL1 in TPO signaling, we established a tetracycline-inducible system in the human TPO-dependent leukemia cell line UT-7/TPO.	tet	76-88	thrombopoietin	Homo sapiens	44-47
11278373-5	2001	To clarify the functional role of FKHRL1 in TPO signaling, we established a tetracycline-inducible system in the human TPO-dependent leukemia cell line UT-7/TPO.	tet	76-88	thrombopoietin	Homo sapiens	119-122
11278373-5	2001	To clarify the functional role of FKHRL1 in TPO signaling, we established a tetracycline-inducible system in the human TPO-dependent leukemia cell line UT-7/TPO.	tet	76-88	thrombopoietin	Homo sapiens	119-122
11287320-8	2001	In another colon cancer cell line, Caco-2, with a tetracycline-regulated promoter system, induction of ERRP expression in the absence of doxycycline was associated with a marked reduction in EGFR activation and proliferation.	tet	50-62	epidermal growth factor receptor	Rattus norvegicus	103-107
11373271-4	2001	We established tetracycline-regulated, stable hRAD50 expression systems in SaOS-2 cells, which retain mutated p53, and in HeLa cells.	tet	15-27	tumor protein p53	Homo sapiens	110-113
11373271-5	2001	After tetracycline withdrawal, cell death and multinucleated giant cells were observed with increased hRAD50 expression, and p21(WAF1/CIP1) but not p53 was increased.	tet	6-18	RAD50 double strand break repair protein	Homo sapiens	102-108
11373271-5	2001	After tetracycline withdrawal, cell death and multinucleated giant cells were observed with increased hRAD50 expression, and p21(WAF1/CIP1) but not p53 was increased.	tet	6-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	129-133
11373271-5	2001	After tetracycline withdrawal, cell death and multinucleated giant cells were observed with increased hRAD50 expression, and p21(WAF1/CIP1) but not p53 was increased.	tet	6-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	134-138
11316778-0	2001	A conditional tetracycline-regulated increase in Gamma amino butyric acid production near luteinizing hormone-releasing hormone nerve terminals disrupts estrous cyclicity in the rat.	tet	14-26	gonadotropin releasing hormone 1	Rattus norvegicus	90-127
11783085-2	2001	METHODS: A nasopharyngeal carcinoma cell line, Tet-on-LMP1 HNE2, transfected with LMP1, the expression of which was regulated by tetracycline, was used in this study.	tet	129-141	PDZ and LIM domain 7	Homo sapiens	82-86
11350908-2	2001	To determine the effects on androgen-independent PC cells of overexpressing cell-surface NEP, an inducible tetracycline-regulatory gene expression system was used to stably introduce and express the NEP gene in androgen-independent TSU-Pr1 cells generating WT-5 cells, which expressed high levels of enzymatically active NEP protein when cultured in the absence of tetracycline.	tet	107-119	membrane metalloendopeptidase	Homo sapiens	199-202
11350908-2	2001	To determine the effects on androgen-independent PC cells of overexpressing cell-surface NEP, an inducible tetracycline-regulatory gene expression system was used to stably introduce and express the NEP gene in androgen-independent TSU-Pr1 cells generating WT-5 cells, which expressed high levels of enzymatically active NEP protein when cultured in the absence of tetracycline.	tet	107-119	membrane metalloendopeptidase	Homo sapiens	199-202
11350908-4	2001	Expression of NEP in WT-5 cells after removal of tetracycline from the media resulted in a >80% inhibition in cell proliferation over a 1-week period (P < 0.005) compared with control cells.	tet	49-61	membrane metallo endopeptidase	Mus musculus	14-17
11350911-2	2001	A p53-null, MGMT-proficient lung tumor cell line (H1299) was engineered to express wt p53 in a tetracycline-regulated system.	tet	95-107	tumor protein p53	Homo sapiens	86-89
11350911-3	2001	High levels of p53 induction achieved by tetracycline withdrawal were accompanied by G(1) cell cycle arrest without significant apoptosis in this cell line.	tet	41-53	tumor protein p53	Homo sapiens	15-18
11331611-3	2001	In this mouse model, overexpression of pmp22 occurs specifically in Schwann cells of the peripheral nerve and is switched off when the mice are fed tetracycline.	tet	148-160	peripheral myelin protein 22	Mus musculus	39-44
11331611-4	2001	Overexpression of pmp22 throughout life (in the absence of tetracycline) causes demyelination.	tet	59-71	peripheral myelin protein 22	Mus musculus	18-23
11331611-5	2001	In contrast, myelination is nearly normal when pmp22 overexpression is switched off throughout life by feeding the mice tetracycline.	tet	120-132	peripheral myelin protein 22	Mus musculus	47-52
11350630-3	2001	When expressed in a tetracycline-dependent manner in HeLa cells, YFP-mu1 was efficiently incorporated into the AP-1 complex, replacing endogenous mu1 in most of cellular AP-1.	tet	20-32	glutathione S-transferase mu 1	Homo sapiens	69-72
11350630-3	2001	When expressed in a tetracycline-dependent manner in HeLa cells, YFP-mu1 was efficiently incorporated into the AP-1 complex, replacing endogenous mu1 in most of cellular AP-1.	tet	20-32	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-115
11350630-3	2001	When expressed in a tetracycline-dependent manner in HeLa cells, YFP-mu1 was efficiently incorporated into the AP-1 complex, replacing endogenous mu1 in most of cellular AP-1.	tet	20-32	glutathione S-transferase mu 1	Homo sapiens	146-149
11278970-7	2001	In H(9)C(2) cardiomyoblasts stably transfected with UCP3 under control of a tetracycline-repressible promotor, removal of doxycycline resulted in detectable levels of UCP3 at 12 h and 2.2-fold induction at 7 days compared with 12 h. In parallel, glucose transport increased 1.3- and 2-fold at 12 h and 7 days, respectively, and the stimulation was inhibited by wortmannin or genistein.	tet	76-88	uncoupling protein 3	Homo sapiens	52-56
11292839-7	2001	Induction of such a stable and viable clone with tetracycline resulted in the expression of functional TBP-DR2.	tet	49-61	TATA-box binding protein	Homo sapiens	103-106
11309283-5	2001	Recombinant NEP and induced NEP expression in TSU-Pr1 cells using a tetracycline-repressive expression system inhibited ET-1-mediated phosphorylation of IGF-IRbeta and Akt, and blocked the protective effects of ET-1 against apoptosis induced by serum starvation.	tet	68-80	membrane metalloendopeptidase	Homo sapiens	12-15
11309283-5	2001	Recombinant NEP and induced NEP expression in TSU-Pr1 cells using a tetracycline-repressive expression system inhibited ET-1-mediated phosphorylation of IGF-IRbeta and Akt, and blocked the protective effects of ET-1 against apoptosis induced by serum starvation.	tet	68-80	membrane metalloendopeptidase	Homo sapiens	28-31
11309283-5	2001	Recombinant NEP and induced NEP expression in TSU-Pr1 cells using a tetracycline-repressive expression system inhibited ET-1-mediated phosphorylation of IGF-IRbeta and Akt, and blocked the protective effects of ET-1 against apoptosis induced by serum starvation.	tet	68-80	endothelin 1	Homo sapiens	120-124
11309283-5	2001	Recombinant NEP and induced NEP expression in TSU-Pr1 cells using a tetracycline-repressive expression system inhibited ET-1-mediated phosphorylation of IGF-IRbeta and Akt, and blocked the protective effects of ET-1 against apoptosis induced by serum starvation.	tet	68-80	AKT serine/threonine kinase 1	Homo sapiens	168-171
11309283-5	2001	Recombinant NEP and induced NEP expression in TSU-Pr1 cells using a tetracycline-repressive expression system inhibited ET-1-mediated phosphorylation of IGF-IRbeta and Akt, and blocked the protective effects of ET-1 against apoptosis induced by serum starvation.	tet	68-80	endothelin 1	Homo sapiens	211-215
11254876-6	2001	We regulated the expression of a dominant negative PKC epsilon mutant (PKC epsilon 1-401 encoding amino acid 1-401) in U-373MG human astrocytoma cells using a tetracycline-regulated expression vector and established stable clones.	tet	159-171	protein kinase C epsilon	Homo sapiens	51-62
11316778-4	2001	Immortalized BAS-8.1 astroglial cells were genetically modified by infection with a regulatable retroviral vector to express the gene encoding the GABA synthesizing enzyme glutamic acid decarboxylase-67 (GAD-67) under the control of a tetracycline (tet) controlled gene expression system.	tet	235-247	glutamate decarboxylase 1	Rattus norvegicus	172-202
11316778-4	2001	Immortalized BAS-8.1 astroglial cells were genetically modified by infection with a regulatable retroviral vector to express the gene encoding the GABA synthesizing enzyme glutamic acid decarboxylase-67 (GAD-67) under the control of a tetracycline (tet) controlled gene expression system.	tet	235-238	glutamate decarboxylase 1	Rattus norvegicus	172-202
11313935-4	2001	In this clone, the BCR gene was placed under the control of a tetracycline (Tet) repression system with a cytomegalovirus (CMV) promoter.	tet	62-74	BCR activator of RhoGEF and GTPase	Mus musculus	19-22
11313935-4	2001	In this clone, the BCR gene was placed under the control of a tetracycline (Tet) repression system with a cytomegalovirus (CMV) promoter.	tet	76-79	BCR activator of RhoGEF and GTPase	Mus musculus	19-22
11313935-5	2001	Induction of exogenous Bcr protein by removal of Tet from the culture medium caused a dramatic increase in Bcr serine kinase activity, yielding predominantly phosphoserine Bcr, despite the presence of Bcr-Abl in the kinase reaction mixture.	tet	49-52	BCR activator of RhoGEF and GTPase	Mus musculus	23-26
11313935-5	2001	Induction of exogenous Bcr protein by removal of Tet from the culture medium caused a dramatic increase in Bcr serine kinase activity, yielding predominantly phosphoserine Bcr, despite the presence of Bcr-Abl in the kinase reaction mixture.	tet	49-52	BCR activator of RhoGEF and GTPase	Mus musculus	107-110
11313935-5	2001	Induction of exogenous Bcr protein by removal of Tet from the culture medium caused a dramatic increase in Bcr serine kinase activity, yielding predominantly phosphoserine Bcr, despite the presence of Bcr-Abl in the kinase reaction mixture.	tet	49-52	BCR activator of RhoGEF and GTPase	Mus musculus	107-110
11313935-5	2001	Induction of exogenous Bcr protein by removal of Tet from the culture medium caused a dramatic increase in Bcr serine kinase activity, yielding predominantly phosphoserine Bcr, despite the presence of Bcr-Abl in the kinase reaction mixture.	tet	49-52	BCR activator of RhoGEF and GTPase	Mus musculus	107-110
11313935-12	2001	Of interest, mice that were fed Tet for 19 days to initiate the disease syndrome and then released from the BCR transcriptional block had a significantly better survival pattern than mice exposed to Tet throughout the entire period.	tet	32-35	BCR activator of RhoGEF and GTPase	Mus musculus	108-111
11254611-1	2001	We have constructed a defined acapsular mutant in Pasteurella multocida X-73 (serogroup A:1) by disrupting the hexA gene through the insertion of a tetracycline resistance cassette.	tet	148-160	hexosaminidase A	Mus musculus	111-115
11254876-6	2001	We regulated the expression of a dominant negative PKC epsilon mutant (PKC epsilon 1-401 encoding amino acid 1-401) in U-373MG human astrocytoma cells using a tetracycline-regulated expression vector and established stable clones.	tet	159-171	protein kinase C epsilon	Homo sapiens	71-82
11254876-7	2001	Induction of expression of the dominant negative PKC epsilon mutant by the addition of doxycycline, a tetracycline derivative, completely blocked proliferation of U-373MG cells in proliferation and clonogenic assays.	tet	102-114	protein kinase C epsilon	Homo sapiens	49-60
11259588-3	2001	Using a tetracycline-inducible expression system, we show that the TCR-mediated activation of both the Ras and calcium pathways was inhibited by expression of CD148 at levels that approximate those found in activated primary T cells.	tet	8-20	protein tyrosine phosphatase receptor type J	Homo sapiens	159-164
11319905-3	2001	We report here a regulated stem cell-based system for controlling bone regeneration, utilizing genetically engineered mesenchymal stem cells (MSCs) harboring a tetracycline-regulated expression vector encoding the osteogenic growth factor human BMP-2.	tet	160-172	bone morphogenetic protein 2	Homo sapiens	245-250
11319905-4	2001	We show that doxycycline (a tetracycline analogue) is able to control hBMP-2 expression and thus control MSC osteogenic differentiation both in vitro and in vivo.	tet	28-40	bone morphogenetic protein 2	Homo sapiens	70-76
11121410-2	2001	Here we report a genetic system developed in the chicken pre-B cell line DT40, in which the endogenous SMN gene is disrupted by homologous recombination, and SMN protein is expressed from a chicken SMN cDNA under control of a tetracycline (tet)-repressible promoter.	tet	226-238	survival of motor neuron	Gallus gallus	158-161
11121410-2	2001	Here we report a genetic system developed in the chicken pre-B cell line DT40, in which the endogenous SMN gene is disrupted by homologous recombination, and SMN protein is expressed from a chicken SMN cDNA under control of a tetracycline (tet)-repressible promoter.	tet	226-238	survival of motor neuron	Gallus gallus	158-161
11121410-2	2001	Here we report a genetic system developed in the chicken pre-B cell line DT40, in which the endogenous SMN gene is disrupted by homologous recombination, and SMN protein is expressed from a chicken SMN cDNA under control of a tetracycline (tet)-repressible promoter.	tet	226-229	survival of motor neuron	Gallus gallus	158-161
11121410-2	2001	Here we report a genetic system developed in the chicken pre-B cell line DT40, in which the endogenous SMN gene is disrupted by homologous recombination, and SMN protein is expressed from a chicken SMN cDNA under control of a tetracycline (tet)-repressible promoter.	tet	226-229	survival of motor neuron	Gallus gallus	158-161
11121410-3	2001	Addition of tet results in depletion of SMN protein and consequent cell death, which directly demonstrates that SMN is required for cell viability.	tet	12-15	survival of motor neuron	Gallus gallus	40-43
11121410-3	2001	Addition of tet results in depletion of SMN protein and consequent cell death, which directly demonstrates that SMN is required for cell viability.	tet	12-15	survival of motor neuron	Gallus gallus	112-115
11121410-4	2001	The tet-induced lethality can be rescued by expression of human SMN, indicating that the function of SMN is highly conserved between the two species.	tet	4-7	survival of motor neuron 1, telomeric	Homo sapiens	64-67
11121410-4	2001	The tet-induced lethality can be rescued by expression of human SMN, indicating that the function of SMN is highly conserved between the two species.	tet	4-7	survival of motor neuron 1, telomeric	Homo sapiens	101-104
11289158-4	2001	By the use of a strict tetracycline-regulation system, we found that the continuous suppression of beta-catenin/TCF4-mediated gene transactivation by dominant-negative TCF4B (deltaN30) reduced these piled-up foci and restored a simple monolayer of polarized columnar cells resembling normal intestinal epithelium.	tet	23-35	catenin beta 1	Rattus norvegicus	99-111
11230179-2	2001	We have shown previously that over-expression of PTEN in a tetracycline-controlled inducible system blocks cell cycle progression and induces apoptosis in MCF-7 breast cancer cells.	tet	59-71	phosphatase and tensin homolog	Homo sapiens	49-53
11289158-4	2001	By the use of a strict tetracycline-regulation system, we found that the continuous suppression of beta-catenin/TCF4-mediated gene transactivation by dominant-negative TCF4B (deltaN30) reduced these piled-up foci and restored a simple monolayer of polarized columnar cells resembling normal intestinal epithelium.	tet	23-35	transcription factor 4	Rattus norvegicus	112-116
11396177-3	2001	OSp16.1 cells, derived from the U24 clone of the U2-OS osteogenic sarcoma tumor line, express the p16INK4a tumor suppressor under the regulation of tetracycline (tet) (Mitra J et al.	tet	148-160	cyclin dependent kinase inhibitor 2A	Mus musculus	98-106
11396177-3	2001	OSp16.1 cells, derived from the U24 clone of the U2-OS osteogenic sarcoma tumor line, express the p16INK4a tumor suppressor under the regulation of tetracycline (tet) (Mitra J et al.	tet	148-151	cyclin dependent kinase inhibitor 2A	Mus musculus	98-106
11396177-5	2001	The in vitro induction of p16 in the OSp16.1 cell line is regulated by tet.	tet	71-74	cyclin dependent kinase inhibitor 2A	Mus musculus	26-29
11332636-3	2001	In this study the forced MyoD-dependent conversion of murine NIH-3T3 fibroblasts into myoblasts under the control of an inducible promoter silent in the presence of tetracycline was evaluated.	tet	165-177	myogenic differentiation 1	Mus musculus	25-29
11319608-6	2001	Using a tricistronic expression vector based on a tetracycline-responsive system we generated stable SKOV3 nd OVCAR3 cell lines with inducible expression of pro-caspase-3.	tet	50-62	caspase 3	Homo sapiens	157-170
11332636-4	2001	After tetracycline withdrawal this promoter drives the transcription of MyoD in the engineered fibroblasts, inducing their myogenesis and giving rise to beta-galactosidase-positive cells.	tet	6-18	myogenic differentiation 1	Mus musculus	72-76
11332636-4	2001	After tetracycline withdrawal this promoter drives the transcription of MyoD in the engineered fibroblasts, inducing their myogenesis and giving rise to beta-galactosidase-positive cells.	tet	6-18	galactosidase, beta 1	Mus musculus	153-171
11332636-9	2001	Our results suggest that transactivation by tetracycline of MyoD may drive an in vivo myogenic conversion of NIH-3T3 fibroblasts and that, in this experimental setting, apoptosis plays a relevant role in limiting the efficacy of engineered fibroblast transplantation.	tet	44-56	myogenic differentiation 1	Mus musculus	60-64
11248678-7	2001	To test this strategy we introduced into human cells a plasmid with a tetracycline-inducible bacterial gpt gene linked to a promoterless luciferase gene, isolated clones with tight gpt expression and used the Cre/loxP site-specific recombination system to swap the gpt gene with the luciferase gene.	tet	70-82	glutamic--pyruvic transaminase	Homo sapiens	103-106
11238890-6	2001	The defective bone marrow populations in BOB.1/OBF.1(-/-) mice were rescued by conditional expression of a BOB.1/OBF.1 transgene controlled by the tetracycline gene expression system.	tet	147-159	POU domain, class 2, associating factor 1	Mus musculus	41-46
11339506-1	2001	OBJECTIVE: Evaluation of tetracycline effects on the expression of MMP-1, MMP-3, tissue inhibitor(s) of metalloproteinase-1 (TIMP-1), plasminogen activators (PA), and PA inhibitor-1, which are all involved in the ultimate regulation of MMP activity could provide new insight into how tetracyclines achieve their cartilage preserving effects.	tet	25-37	interstitial collagenase	Bos taurus	67-72
11339506-1	2001	OBJECTIVE: Evaluation of tetracycline effects on the expression of MMP-1, MMP-3, tissue inhibitor(s) of metalloproteinase-1 (TIMP-1), plasminogen activators (PA), and PA inhibitor-1, which are all involved in the ultimate regulation of MMP activity could provide new insight into how tetracyclines achieve their cartilage preserving effects.	tet	25-37	stromelysin-1	Bos taurus	74-79
11339506-1	2001	OBJECTIVE: Evaluation of tetracycline effects on the expression of MMP-1, MMP-3, tissue inhibitor(s) of metalloproteinase-1 (TIMP-1), plasminogen activators (PA), and PA inhibitor-1, which are all involved in the ultimate regulation of MMP activity could provide new insight into how tetracyclines achieve their cartilage preserving effects.	tet	25-37	TIMP metallopeptidase inhibitor 1	Bos taurus	125-131
11339506-1	2001	OBJECTIVE: Evaluation of tetracycline effects on the expression of MMP-1, MMP-3, tissue inhibitor(s) of metalloproteinase-1 (TIMP-1), plasminogen activators (PA), and PA inhibitor-1, which are all involved in the ultimate regulation of MMP activity could provide new insight into how tetracyclines achieve their cartilage preserving effects.	tet	25-37	interstitial collagenase	Bos taurus	67-70
11339506-9	2001	Production of MMP-3 was only decreased by tetracycline (IC50 = 45.4 microM).	tet	42-54	stromelysin-1	Bos taurus	14-19
11434870-5	2001	In an exciting recent finding, D"Cruz et al discovered tetracycline-regulated c-Myc overexpression in the mammary gland induced invasive mammary tumors that regressed upon withdrawal of c-Myc expression.	tet	55-67	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	78-83
11434870-5	2001	In an exciting recent finding, D"Cruz et al discovered tetracycline-regulated c-Myc overexpression in the mammary gland induced invasive mammary tumors that regressed upon withdrawal of c-Myc expression.	tet	55-67	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	186-191
11196179-5	2001	A 3-day treatment of Tet-FGF2 cell cultures with tetracycline abolished FGF2 overexpression and the biological activity of the conditioned medium without affecting their proliferative capacity.	tet	49-61	fibroblast growth factor 2	Homo sapiens	25-29
11196179-5	2001	A 3-day treatment of Tet-FGF2 cell cultures with tetracycline abolished FGF2 overexpression and the biological activity of the conditioned medium without affecting their proliferative capacity.	tet	49-61	fibroblast growth factor 2	Homo sapiens	72-76
11196179-7	2001	The administration of 2.0 mg/ml tetracycline in the drinking water before cell transplantation, continued throughout the whole experiment, inhibited FGF2 expression in Tet-FGF2 tumor lesions.	tet	32-44	fibroblast growth factor 2	Homo sapiens	149-153
11196179-7	2001	The administration of 2.0 mg/ml tetracycline in the drinking water before cell transplantation, continued throughout the whole experiment, inhibited FGF2 expression in Tet-FGF2 tumor lesions.	tet	32-44	fibroblast growth factor 2	Homo sapiens	172-176
11196179-9	2001	Tetracycline administration 20 days after tumor cell implant, although equally effective in reducing FGF2 expression and inhibiting tumor vascularity, only minimally impaired the growth of established Tet-FGF2 tumors.	tet	0-12	fibroblast growth factor 2	Homo sapiens	101-105
11196179-9	2001	Tetracycline administration 20 days after tumor cell implant, although equally effective in reducing FGF2 expression and inhibiting tumor vascularity, only minimally impaired the growth of established Tet-FGF2 tumors.	tet	0-12	fibroblast growth factor 2	Homo sapiens	205-209
11775025-6	2001	Stable transfectants containing a tetracycline repressible expression vector were used to induce expression of Rac mutants.	tet	34-46	thymoma viral proto-oncogene 1	Mus musculus	111-114
11746518-5	2001	To systematically investigate the molecular mechanisms responsible for these effects of CK2beta on cell proliferation, we generated human osteosarcoma U2OS cell lines with tetracycline-regulated expression of CK2beta.	tet	172-184	casein kinase 2 beta	Homo sapiens	88-95
11746518-5	2001	To systematically investigate the molecular mechanisms responsible for these effects of CK2beta on cell proliferation, we generated human osteosarcoma U2OS cell lines with tetracycline-regulated expression of CK2beta.	tet	172-184	casein kinase 2 beta	Homo sapiens	209-216
11134178-2	2001	We have used tetracycline-regulated transcription in conjunction with a cartilage-specific promoter to target a constitutively active human MMP-13 to the hyaline cartilages and joints of transgenic mice.	tet	13-25	matrix metallopeptidase 13	Homo sapiens	140-146
11084022-2	2001	We have constructed a cell line derived from the rat pheochromocytoma PC12 in which expression of a constitutively active mutant of ALK7 (T194D) is under the control of a tetracycline-inducible promoter.	tet	171-183	activin A receptor type 1C	Rattus norvegicus	132-136
11084022-3	2001	For comparison, another cell line was engineered with tetracycline-regulated expression of a constitutively active variant of the transforming growth factor-beta type I receptor ALK5.	tet	54-66	transforming growth factor, beta receptor 1	Rattus norvegicus	178-182
11161315-0	2001	Generation of a mammalian cell line stably expressing a tetracycline-regulated epitope-tagged human androgen receptor: implications for steroid hormone receptor research.	tet	56-68	androgen receptor	Homo sapiens	100-117
11161315-5	2001	We show that f:AR expression in E19 cells can be precisely modulated by varying the concentration of tetracycline or its chemical derivative doxycycline in the growth media.	tet	101-113	androgen receptor	Homo sapiens	15-17
11245488-2	2001	We expressed dominant-negative FGFR2 (FGFR2-DN) or FGFR1 (FGFR1-DN) in glioma C6 cells by using constitutive or tetracycline-regulated expression systems.	tet	112-124	fibroblast growth factor receptor 2	Rattus norvegicus	31-36
11160939-0	2001	Streptogramin- and tetracycline-responsive dual regulated expression of p27(Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells.	tet	19-31	zinc ribbon domain containing 2	Homo sapiens	72-75
11160939-0	2001	Streptogramin- and tetracycline-responsive dual regulated expression of p27(Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells.	tet	19-31	cyclin-dependent kinase inhibitor 1B	Cricetulus griseus	76-80
11160939-5	2001	In a second system, a derivative of pDuoRex encoding streptogramin-responsive expression of the growth-promoting SV40 small T antigen (sT) and tetracycline-regulated expression of p27(Kip1) was stably transfected into CHO cells.	tet	143-155	zinc ribbon domain containing 2	Homo sapiens	180-183
11160939-5	2001	In a second system, a derivative of pDuoRex encoding streptogramin-responsive expression of the growth-promoting SV40 small T antigen (sT) and tetracycline-regulated expression of p27(Kip1) was stably transfected into CHO cells.	tet	143-155	cyclin-dependent kinase inhibitor 1B	Cricetulus griseus	184-188
11160943-0	2001	A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain.	tet	8-20	E2F transcription factor 4	Homo sapiens	51-55
11162629-4	2001	To confirm that these changes were specific for Bcl-2 we generated a bcl-2 antisense construct under the control of the tetracycline responsive promotor.	tet	120-132	BCL2 apoptosis regulator	Homo sapiens	48-53
11162629-4	2001	To confirm that these changes were specific for Bcl-2 we generated a bcl-2 antisense construct under the control of the tetracycline responsive promotor.	tet	120-132	BCL2 apoptosis regulator	Homo sapiens	69-74
11172680-0	2001	CMT-3, a non-antimicrobial tetracycline (TC), inhibits MT1-MMP activity: relevance to cancer.	tet	41-43	matrix metallopeptidase 14	Homo sapiens	55-62
11172680-6	2001	The inhibition of MT1-MMP by CMT-3 may partially explain the inhibition of cancer cell -mediated tissue breakdown and invasiveness by this non-antimicrobial tetracycline analog.	tet	157-169	matrix metallopeptidase 14	Homo sapiens	18-25
11172683-0	2001	Wound healing in ovariectomized rats: effects of chemically modified tetracycline (CMT-8) and estrogen on matrix metalloproteinases -8, -13 and type I collagen expression.	tet	69-81	matrix metallopeptidase 8	Rattus norvegicus	106-159
11165872-9	2001	To further determine the specificity in MnSOD-induced gene regulation, MCF+SOD cells were stably transfected with an antisense MnSOD sequence whose expression was controlled by a tetracycline-inducible regulator.	tet	179-191	superoxide dismutase 2	Homo sapiens	40-45
11165872-9	2001	To further determine the specificity in MnSOD-induced gene regulation, MCF+SOD cells were stably transfected with an antisense MnSOD sequence whose expression was controlled by a tetracycline-inducible regulator.	tet	179-191	superoxide dismutase 2	Homo sapiens	127-132
11154260-9	2001	A HeLa cell tetracycline-regulated reporter system was used to determine the effect of HuR on mRNA stability.	tet	12-24	ELAV like RNA binding protein 1	Homo sapiens	87-90
11154265-2	2001	A tetracycline-regulated reporter system was used to investigate mechanisms of regulation of Cox-2 mRNA stability.	tet	2-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	93-98
11158294-5	2001	We found that induction of p53 either by diverse stress signals or ectopically using a tetracycline-regulated promoter causes a marked reduction in CHK1 protein levels.	tet	87-99	tumor protein p53	Homo sapiens	27-30
11158294-5	2001	We found that induction of p53 either by diverse stress signals or ectopically using a tetracycline-regulated promoter causes a marked reduction in CHK1 protein levels.	tet	87-99	checkpoint kinase 1	Homo sapiens	148-152
11175856-3	2001	Here we use the tetracycline regulatory system to conditionally express the human c-MYC oncogene in the mammary epithelium of transgenic mice.	tet	16-28	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-87
11146231-3	2001	By employing a functional approach we examined the role of DAP-5 in human neuroblastoma cells that are sensitized for IFNgamma-induced apoptosis by tetracycline controlled MYCN expression.	tet	148-160	eukaryotic translation initiation factor 4 gamma 2	Homo sapiens	59-64
11146231-3	2001	By employing a functional approach we examined the role of DAP-5 in human neuroblastoma cells that are sensitized for IFNgamma-induced apoptosis by tetracycline controlled MYCN expression.	tet	148-160	interferon gamma	Homo sapiens	118-126
11146231-3	2001	By employing a functional approach we examined the role of DAP-5 in human neuroblastoma cells that are sensitized for IFNgamma-induced apoptosis by tetracycline controlled MYCN expression.	tet	148-160	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	172-176
11313964-7	2001	Using tetracycline-regulated expression system, we showed that overexpression of 14-3-3beta stimulated cell spreading and migration on fibronectin but not on poly-L-lysine.	tet	6-18	fibronectin 1	Homo sapiens	135-146
11212232-6	2001	We found that induction of RB2/p130 expression using a tetracycline-regulated gene expression system as well as retroviral and adenoviral-mediated gene delivery inhibited angiogenesis in vivo.	tet	55-67	RB transcriptional corepressor like 2	Mus musculus	27-30
11212232-6	2001	We found that induction of RB2/p130 expression using a tetracycline-regulated gene expression system as well as retroviral and adenoviral-mediated gene delivery inhibited angiogenesis in vivo.	tet	55-67	RB transcriptional corepressor like 2	Mus musculus	31-35
11238890-6	2001	The defective bone marrow populations in BOB.1/OBF.1(-/-) mice were rescued by conditional expression of a BOB.1/OBF.1 transgene controlled by the tetracycline gene expression system.	tet	147-159	POU domain, class 2, associating factor 1	Mus musculus	47-52
11238890-6	2001	The defective bone marrow populations in BOB.1/OBF.1(-/-) mice were rescued by conditional expression of a BOB.1/OBF.1 transgene controlled by the tetracycline gene expression system.	tet	147-159	POU domain, class 2, associating factor 1	Mus musculus	107-112
11238890-6	2001	The defective bone marrow populations in BOB.1/OBF.1(-/-) mice were rescued by conditional expression of a BOB.1/OBF.1 transgene controlled by the tetracycline gene expression system.	tet	147-159	POU domain, class 2, associating factor 1	Mus musculus	113-118
11147995-0	2000	Functional and histochemical analysis of MDR3 P-glycoprotein in a tetracycline-controlled gene expression system.	tet	66-78	ATP binding cassette subfamily B member 4	Homo sapiens	41-45
11822776-8	2001	A qacC harboring S. epidermidis strain (St.17) also hybridized to tetK (tetracycline resistance) and ermB (erythromycin resistance) genes.	tet	72-84	QacC	Staphylococcus epidermidis	2-6
11147995-0	2000	Functional and histochemical analysis of MDR3 P-glycoprotein in a tetracycline-controlled gene expression system.	tet	66-78	ATP binding cassette subfamily B member 1	Homo sapiens	46-60
11175264-1	2000	To understand the roles of bcl-2 for the survival of leukemic cells, we constructed human leukemic HL60 transformant lines in which full length bcl-2 antisense message was conditionally expressed by a tetracycline-regulatable expression system.	tet	201-213	BCL2 apoptosis regulator	Homo sapiens	144-149
11010972-5	2000	First, induction of BCR/ABL by a tetracycline-regulated promoter is associated with a reversible down-regulation of p27(Kip1).	tet	33-45	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	20-27
11010972-5	2000	First, induction of BCR/ABL by a tetracycline-regulated promoter is associated with a reversible down-regulation of p27(Kip1).	tet	33-45	interferon alpha inducible protein 27	Homo sapiens	116-119
11010972-5	2000	First, induction of BCR/ABL by a tetracycline-regulated promoter is associated with a reversible down-regulation of p27(Kip1).	tet	33-45	cyclin dependent kinase inhibitor 1B	Homo sapiens	120-124
10978316-3	2000	MCF-7 human breast carcinoma cells were transfected with tetracycline-regulated (Tet-off) SSAT human cDNA or murine gene.	tet	57-69	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	90-94
11332280-2	2000	In this report, we explored improving the vector titers by isolating a Vero cell line that uses the tetracycline-regulated promoter system to induce HSV-1 VP16 at the beginning of the packaging procedure.	tet	100-112	host cell factor C1	Homo sapiens	155-159
11073992-3	2000	In the present study, we have examined Myf5 proteolysis through stable transfection of myogenically convertible U20S cells with Myf5 derivatives under the control of a tetracycline-sensitive promoter.	tet	168-180	myogenic factor 5	Homo sapiens	39-43
11099472-3	2000	NRP1 was overexpressed in Dunning rat prostate carcinoma AT2.1 cells using a tetracycline-inducible promoter.	tet	77-89	neuropilin 1	Rattus norvegicus	0-4
11099472-4	2000	Concomitant with increased NRP1 expression in response to a tetracycline homologue, doxycycline (Dox), basal cell motility, and VEGF(165) binding were increased three- to fourfold in vitro.	tet	60-72	neuropilin 1	Rattus norvegicus	27-31
11104793-5	2000	Constitutively expressed NEP, recombinant NEP, and induced NEP expression using a tetracycline-repressive expression system inhibited bombesin- and endothelin-1-stimulated FAK phosphorylation and cell migration.	tet	82-94	gastrin releasing peptide	Homo sapiens	134-142
11104793-5	2000	Constitutively expressed NEP, recombinant NEP, and induced NEP expression using a tetracycline-repressive expression system inhibited bombesin- and endothelin-1-stimulated FAK phosphorylation and cell migration.	tet	82-94	endothelin 1	Homo sapiens	148-160
11104793-5	2000	Constitutively expressed NEP, recombinant NEP, and induced NEP expression using a tetracycline-repressive expression system inhibited bombesin- and endothelin-1-stimulated FAK phosphorylation and cell migration.	tet	82-94	protein tyrosine kinase 2	Homo sapiens	172-175
11107122-2	2000	PROCEDURE: To investigate the effect of ectopic MycN expression on the susceptibility of neuroblastoma cells to cytotoxic drugs, we used a human neuroblastoma cell line with tetracycline-controlled expression of MycN.	tet	174-186	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	212-216
11114732-2	2000	We established a cell line in which FAK gene was conditionally inducible by use of FAK-null fibroblasts and the tetracycline repression system.	tet	112-124	protein tyrosine kinase 2	Homo sapiens	36-39
11124058-2	2000	To achieve combined cell-type-specific transcriptional targeting and inducible expression, we have engineered the expression of the tetracycline-dependent transcriptional elements (1) to be under the transcriptional control of either the astrocyte-specific, glial fibrillary acidic protein (GFAP) (2) or the neuronal specific enolase (NSE) promoter (3) within a dual adenoviral vector system.	tet	132-144	glial fibrillary acidic protein	Homo sapiens	258-289
11124058-2	2000	To achieve combined cell-type-specific transcriptional targeting and inducible expression, we have engineered the expression of the tetracycline-dependent transcriptional elements (1) to be under the transcriptional control of either the astrocyte-specific, glial fibrillary acidic protein (GFAP) (2) or the neuronal specific enolase (NSE) promoter (3) within a dual adenoviral vector system.	tet	132-144	glial fibrillary acidic protein	Homo sapiens	291-295
11124058-2	2000	To achieve combined cell-type-specific transcriptional targeting and inducible expression, we have engineered the expression of the tetracycline-dependent transcriptional elements (1) to be under the transcriptional control of either the astrocyte-specific, glial fibrillary acidic protein (GFAP) (2) or the neuronal specific enolase (NSE) promoter (3) within a dual adenoviral vector system.	tet	132-144	enolase 2	Homo sapiens	308-333
11124058-2	2000	To achieve combined cell-type-specific transcriptional targeting and inducible expression, we have engineered the expression of the tetracycline-dependent transcriptional elements (1) to be under the transcriptional control of either the astrocyte-specific, glial fibrillary acidic protein (GFAP) (2) or the neuronal specific enolase (NSE) promoter (3) within a dual adenoviral vector system.	tet	132-144	enolase 2	Homo sapiens	335-338
11124058-4	2000	We demonstrate that the GFAP promoter is able to restrict tetracycline-dependent transgene expression to glial cells in cell lines, primary cultures, and in the CNS in vivo.	tet	58-70	glial fibrillary acidic protein	Homo sapiens	24-28
10967120-4	2000	The tetracycline-inducible system was employed to achieve tightly controlled expression of both wild type (WT) and dominant-negative mutant (DN) of HNF4alpha in INS-1 cells.	tet	4-16	hepatocyte nuclear factor 4, alpha	Rattus norvegicus	148-157
11114732-3	2000	In this cell line, FAK expression was undetectable in the presence of tetracycline but induced within 1 day by the removal of the drug.	tet	70-82	protein tyrosine kinase 2	Homo sapiens	19-22
11053399-1	2000	An Asp or Asn substitution for Gly247 in transmembrane helix 8 (TM-8) of Tet(B), the tetracycline efflux protein, eliminated tetracycline resistance.	tet	85-97	tetraspanin 16	Homo sapiens	64-68
11053399-1	2000	An Asp or Asn substitution for Gly247 in transmembrane helix 8 (TM-8) of Tet(B), the tetracycline efflux protein, eliminated tetracycline resistance.	tet	125-137	tetraspanin 16	Homo sapiens	64-68
11069615-0	2000	Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter.	tet	74-86	RT1 class I, locus A	Rattus norvegicus	121-124
11069615-1	2000	To produce conditional expression of genes in the mouse epidermis we have generated transgenic mouse lines in which the tetracycline-regulated transcriptional transactivators, tTA and rTA, are linked to the bovine keratin 5 promoter.	tet	120-132	RT1 class I, locus A	Rattus norvegicus	184-187
11108661-3	2000	When a tetracycline-regulatable dominant-negative c-jun (TAM67, having a truncated transactivation domain) was expressed in tumorigenic human keratinocytes, AP-1- and NFkappaB- but not p53-dependent reporter activity was inhibited by 40-60%.	tet	7-19	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-55
11027272-5	2000	Likewise, expression of a tetracycline-regulated wild-type p53 cDNA in p53-null fibroblasts caused a reduction in 53BP2 protein levels.	tet	26-38	tumor protein p53	Homo sapiens	59-62
11027272-5	2000	Likewise, expression of a tetracycline-regulated wild-type p53 cDNA in p53-null fibroblasts caused a reduction in 53BP2 protein levels.	tet	26-38	tumor protein p53	Homo sapiens	71-74
11027272-5	2000	Likewise, expression of a tetracycline-regulated wild-type p53 cDNA in p53-null fibroblasts caused a reduction in 53BP2 protein levels.	tet	26-38	tumor protein p53 binding protein 2	Homo sapiens	114-119
11027272-6	2000	However, 53BP2 levels were not reduced if the tetracycline-regulated p53 cDNA was expressed after UV damage in these cells.	tet	46-58	tumor protein p53	Homo sapiens	69-72
11108661-3	2000	When a tetracycline-regulatable dominant-negative c-jun (TAM67, having a truncated transactivation domain) was expressed in tumorigenic human keratinocytes, AP-1- and NFkappaB- but not p53-dependent reporter activity was inhibited by 40-60%.	tet	7-19	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-161
11108661-3	2000	When a tetracycline-regulatable dominant-negative c-jun (TAM67, having a truncated transactivation domain) was expressed in tumorigenic human keratinocytes, AP-1- and NFkappaB- but not p53-dependent reporter activity was inhibited by 40-60%.	tet	7-19	nuclear factor kappa B subunit 1	Homo sapiens	167-175
11108661-3	2000	When a tetracycline-regulatable dominant-negative c-jun (TAM67, having a truncated transactivation domain) was expressed in tumorigenic human keratinocytes, AP-1- and NFkappaB- but not p53-dependent reporter activity was inhibited by 40-60%.	tet	7-19	tumor protein p53	Homo sapiens	185-188
11228549-3	2000	We now describe the properties of four lines that express different levels of the neutrophil chemokine, interleukin-8 (IL-8), from a tetracycline (TET)-responsive promoter.	tet	133-145	chemokine (C-X-C motif) ligand 15	Mus musculus	104-117
11228549-3	2000	We now describe the properties of four lines that express different levels of the neutrophil chemokine, interleukin-8 (IL-8), from a tetracycline (TET)-responsive promoter.	tet	133-145	chemokine (C-X-C motif) ligand 15	Mus musculus	119-123
11228549-3	2000	We now describe the properties of four lines that express different levels of the neutrophil chemokine, interleukin-8 (IL-8), from a tetracycline (TET)-responsive promoter.	tet	147-150	chemokine (C-X-C motif) ligand 15	Mus musculus	104-117
11228549-3	2000	We now describe the properties of four lines that express different levels of the neutrophil chemokine, interleukin-8 (IL-8), from a tetracycline (TET)-responsive promoter.	tet	147-150	chemokine (C-X-C motif) ligand 15	Mus musculus	119-123
11228549-6	2000	Administration of TET was effective in lowering the neutrophil content of low IL-8-expressing tumors, but not high IL-8-expressing tumors.	tet	18-21	chemokine (C-X-C motif) ligand 15	Mus musculus	78-82
10998355-5	2000	Analysis of mRNA stability using the tetracycline-repressible promoter system and/or actinomycin D indicates that COX VIa-L mRNA decays with a half-life of approximately 5-6 h in both myoblasts and myotubes, whereas COX VIa-H and Va mRNAs decay with half-lives of > 15 h in myotubes.	tet	37-49	cytochrome c oxidase subunit 6A1	Mus musculus	118-123
11033356-4	2000	An adenosine/uridine-rich element from the TNFalpha 3" untranslated region conferred p38-sensitive decay in a tetracycline-regulated mRNA stability assay.	tet	110-122	tumor necrosis factor	Mus musculus	43-51
11033356-4	2000	An adenosine/uridine-rich element from the TNFalpha 3" untranslated region conferred p38-sensitive decay in a tetracycline-regulated mRNA stability assay.	tet	110-122	mitogen-activated protein kinase 14	Mus musculus	85-88
11069081-5	2000	To study the function of FKHR, we engineered mice expressing a dominant-negative mutant specifically in T cells in a tetracycline-regulatable fashion.	tet	117-129	forkhead box O1	Mus musculus	25-29
11053453-0	2000	Increased leakiness of the tetracycline-inducible Triple-Op promoter in dividing cells renders it unsuitable for high inducible levels of a dominant negative CDC2aAt gene.	tet	27-39	cell division control 2	Arabidopsis thaliana	158-165
11053453-1	2000	A tetracycline-inducible promoter system was used to generate transgenic tobacco plants that confer inducible expression of the wild type or a dominant negative allele of the gene coding for the cyclin-dependent kinase (CDK) of Arabidopsis thaliana CDC2aAt.	tet	2-14	cell division control 2	Arabidopsis thaliana	249-256
10982843-2	2000	Here, we show that tetracycline-regulated SSeCKS expression in NIH 3T3 cells induces G(1) arrest marked by extracellular signal-regulated kinase 2-dependent decreases in cyclin D1 expression and pRb phosphorylation.	tet	19-31	A kinase (PRKA) anchor protein (gravin) 12	Mus musculus	42-48
10982831-7	2000	We generated stable cell lines with tetracycline-regulated expression of hsp70, hsc70, and chaperone-defective hsp70 mutants lacking the ATPase domain or the C-terminal EEVD sequence or containing AAAA in place of EEVD.	tet	36-48	heat shock protein family A (Hsp70) member 4	Homo sapiens	73-78
10982831-7	2000	We generated stable cell lines with tetracycline-regulated expression of hsp70, hsc70, and chaperone-defective hsp70 mutants lacking the ATPase domain or the C-terminal EEVD sequence or containing AAAA in place of EEVD.	tet	36-48	heat shock protein family A (Hsp70) member 8	Homo sapiens	80-85
10982831-7	2000	We generated stable cell lines with tetracycline-regulated expression of hsp70, hsc70, and chaperone-defective hsp70 mutants lacking the ATPase domain or the C-terminal EEVD sequence or containing AAAA in place of EEVD.	tet	36-48	heat shock protein family A (Hsp70) member 4	Homo sapiens	111-116
10982831-7	2000	We generated stable cell lines with tetracycline-regulated expression of hsp70, hsc70, and chaperone-defective hsp70 mutants lacking the ATPase domain or the C-terminal EEVD sequence or containing AAAA in place of EEVD.	tet	36-48	dynein axonemal heavy chain 8	Homo sapiens	137-143
11144420-5	2000	The overall frequency of drug resistance traits among the 1,749 MRSA strains was high (over 70% and up to and over 90% of the strains) to ciprofloxacin, erythromycin, clindamycin, gentamicin, and tetracycline, and was somewhat less frequent to sulfamethoxazole-trimethoprim (45%), chloramphenicol (30%), and rifampin (38%).	tet	196-208	solute carrier family 9 member A6	Homo sapiens	64-68
10998335-5	2000	The new cell line with the tTA-inducible E2a expression cassette can significantly increase the titer of E1/E2a-deleted vectors by four to five orders of magnitude upon withdrawal of tetracycline.	tet	183-195	transcription factor 3	Homo sapiens	41-44
10998335-5	2000	The new cell line with the tTA-inducible E2a expression cassette can significantly increase the titer of E1/E2a-deleted vectors by four to five orders of magnitude upon withdrawal of tetracycline.	tet	183-195	transcription factor 3	Homo sapiens	108-111
11372377-0	2000	[Inducible expression of MSP1 gene of Plasmodium falciparum by a tetracycline controlled promoter in Salmonella typhi CVD908 strain].	tet	65-77	salivary protein electrophoretic 1, regulator	Mus musculus	25-29
11372377-1	2000	OBJECTIVE: To investigate the inducible expression of MSP1 gene of Plasmodium falciparum in Salmonella typhi CVD908 vaccine strain using a tetracycline-controlled PLtetO promoter.	tet	139-151	salivary protein electrophoretic 1, regulator	Mus musculus	54-58
11372377-4	2000	RESULTS: The CVD908/tetR/MSP1-42 strain was constructed and the expression of MSP1-42 was dependent on the presence of tetracycline in vitro.	tet	119-131	salivary protein electrophoretic 1, regulator	Mus musculus	25-29
11372377-4	2000	RESULTS: The CVD908/tetR/MSP1-42 strain was constructed and the expression of MSP1-42 was dependent on the presence of tetracycline in vitro.	tet	119-131	salivary protein electrophoretic 1, regulator	Mus musculus	78-82
11372377-6	2000	Moreover, the MSP1-42 was expressed in the liver and spleen of mice inoculated with the CVD908/tetR/MSP1-42 strain in the presence of tetracycline, whereas no expression was detected in the absence of the inducer.	tet	134-146	salivary protein electrophoretic 1, regulator	Mus musculus	14-18
11372377-7	2000	CONCLUSION: The recombinant Salmonella typhi strain which expresses the MSP1-42 fragment of Plasmodium falciparum induced by tetracycline has been established successfully.	tet	125-137	salivary protein electrophoretic 1, regulator	Mus musculus	72-76
11866936-0	2000	[Effect of mouse p53 minigene on lung cancer cells with different 172 structures regulated by tetracycline].	tet	94-106	transformation related protein 53, pseudogene	Mus musculus	17-20
11866936-2	2000	METHODS: Three variant types of p53 minigene were sub-cloned by gene recombination into an expression vector which was controlled by tetracycline.	tet	133-145	transformation related protein 53, pseudogene	Mus musculus	32-35
10956386-4	2000	As a model for myc activation in BL cells, we have established a human EBV-EBNA1 positive B-cell line, P493-6, in which myc is expressed under the control of a tetracycline regulated promoter.	tet	160-172	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	15-18
10956386-4	2000	As a model for myc activation in BL cells, we have established a human EBV-EBNA1 positive B-cell line, P493-6, in which myc is expressed under the control of a tetracycline regulated promoter.	tet	160-172	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	120-123
10979955-4	2000	Therefore, mice were generated in which the expression of AML1-ETO is under the control of a tetracycline-inducible system.	tet	93-105	runt related transcription factor 1	Mus musculus	58-62
10979955-4	2000	Therefore, mice were generated in which the expression of AML1-ETO is under the control of a tetracycline-inducible system.	tet	93-105	RUNX1 translocation partner 1	Mus musculus	63-66
10979955-5	2000	Multiple lines of transgenic mice have been produced with the AML1-ETO complementary DNA controlled by a tetracycline-responsive element.	tet	105-117	runt related transcription factor 1	Mus musculus	62-66
10979955-7	2000	Furthermore, the addition of tetracycline reduces AML1-ETO expression in double-positive mice to nondetectable levels.	tet	29-41	runt related transcription factor 1	Mus musculus	50-54
10979955-7	2000	Furthermore, the addition of tetracycline reduces AML1-ETO expression in double-positive mice to nondetectable levels.	tet	29-41	RUNX1 translocation partner 1	Mus musculus	55-58
10979976-3	2000	We generated sublines of Ba/F3 cells in which either wild-type STAT5 or a constitutively active mutant of STAT5 (STAT5-1*6) were expressed under the control of a tetracycline-inducible promoter.	tet	162-174	signal transducer and activator of transcription 5A	Mus musculus	63-68
10979976-3	2000	We generated sublines of Ba/F3 cells in which either wild-type STAT5 or a constitutively active mutant of STAT5 (STAT5-1*6) were expressed under the control of a tetracycline-inducible promoter.	tet	162-174	signal transducer and activator of transcription 5A	Mus musculus	106-111
10979976-3	2000	We generated sublines of Ba/F3 cells in which either wild-type STAT5 or a constitutively active mutant of STAT5 (STAT5-1*6) were expressed under the control of a tetracycline-inducible promoter.	tet	162-174	signal transducer and activator of transcription 5A	Mus musculus	113-122
10996844-3	2000	To accomplish this, gp130 protein levels were modulated using a tetracycline-regulated expression system in a stromal/osteoblastic cell line, UAMS-32, which supports osteoclast formation.	tet	64-76	interleukin 6 cytokine family signal transducer	Homo sapiens	20-25
10974076-5	2000	METHODS: We overexpressed p21 with a tetracycline-inducible system in ER-negative, p21-negative breast cancer cells.	tet	37-49	cyclin dependent kinase inhibitor 1A	Homo sapiens	26-29
10974076-5	2000	METHODS: We overexpressed p21 with a tetracycline-inducible system in ER-negative, p21-negative breast cancer cells.	tet	37-49	estrogen receptor 1	Homo sapiens	70-72
10974076-5	2000	METHODS: We overexpressed p21 with a tetracycline-inducible system in ER-negative, p21-negative breast cancer cells.	tet	37-49	cyclin dependent kinase inhibitor 1A	Homo sapiens	83-86
10980131-5	2000	However, the inducible expression of p57 in three well-characterized human astrocytoma cell lines (U343 MG-A, U87 MG, and U373 MG) using the tetracycline repressor system leads to a potent proliferative block in G(1) as determined by growth curve and flow cytometric analyses.	tet	141-153	cyclin dependent kinase inhibitor 1C	Homo sapiens	37-40
11027163-4	2000	Streptogramin-inducible and tetracycline-repressible pTRIDENT derivatives were used to simultaneously control expression of three fluorescent proteins in mammalian cells: the enhanced cyan fluorescent protein (CFP), the recently isolated red fluorescent protein (RFP, also designated dsRed), and the enhanced yellow fluorescent protein (YFP).	tet	28-40	tripartite motif containing 27	Homo sapiens	238-261
10987283-2	2000	A colorectal carcinoma cell line, DLD-1, was engineered to suppress transactivation by the TCF4/beta-catenin complex in a dominant-negative manner under the strict control of the tetracycline regulatory system.	tet	179-191	transcription factor 4	Homo sapiens	91-95
10987283-2	2000	A colorectal carcinoma cell line, DLD-1, was engineered to suppress transactivation by the TCF4/beta-catenin complex in a dominant-negative manner under the strict control of the tetracycline regulatory system.	tet	179-191	catenin beta 1	Homo sapiens	96-108
10934044-2	2000	In this report, we have analyzed the potential role and mechanism of Pyk2, a tyrosine kinase closely related to FAK, in cell cycle regulation by using tetracycline-regulated expression system as well as chimeric molecules.	tet	151-163	protein tyrosine kinase 2 beta	Homo sapiens	69-73
11045432-9	2000	CONCLUSION: These results indicate that proteins encoded in the HSV-1 genome, especially the transactivating immediate early gene products (ICP4, ICP27 and ICP0) and the VP16 tegument protein can activate the tetO/ minimal CMV promoter and thereby interfere with the integrity of tetracycline-regulated transgene expression.	tet	280-292	host cell factor C1	Homo sapiens	170-174
10954612-2	2000	We first inserted a PCR fragment carrying the tetracycline resistance gene (TetR) into the beta-globin gene.	tet	46-58	tetracycline resistance repressor protein TetR	Escherichia coli	76-80
10963680-8	2000	S9 cells were obtained by retroviral infection with virions containing a tetracycline-regulated sense AS3 construct.	tet	73-85	PDS5 cohesin associated factor B	Homo sapiens	102-105
10963680-9	2000	In these cells, sense AS3 was negatively regulated by tetracycline.	tet	54-66	PDS5 cohesin associated factor B	Homo sapiens	22-25
10963680-10	2000	Tetracycline withdrawal increased the expression of AS3 mRNA and protein.	tet	0-12	PDS5 cohesin associated factor B	Homo sapiens	52-55
10963680-11	2000	The expression of tetracycline-regulated AS3 resulted in inhibition of cell proliferation.	tet	18-30	PDS5 cohesin associated factor B	Homo sapiens	41-44
10963680-12	2000	A4 cells were obtained by retroviral infection with virions containing a tetracycline-regulated antisense AS3 construct.	tet	73-85	PDS5 cohesin associated factor B	Homo sapiens	106-109
10835420-6	2000	SHP-1 associated transiently with p120(ctn) in EGF-stimulated A431 cells stably transfected with a tetracycline-responsive SHP-1 expression construct, and p120(ctn) exhibited elevated phosphorylation upon a tetracycline-mediated decrease in the SHP-1 level.	tet	99-111	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	0-5
10835420-6	2000	SHP-1 associated transiently with p120(ctn) in EGF-stimulated A431 cells stably transfected with a tetracycline-responsive SHP-1 expression construct, and p120(ctn) exhibited elevated phosphorylation upon a tetracycline-mediated decrease in the SHP-1 level.	tet	99-111	catenin delta 1	Homo sapiens	39-42
10835420-6	2000	SHP-1 associated transiently with p120(ctn) in EGF-stimulated A431 cells stably transfected with a tetracycline-responsive SHP-1 expression construct, and p120(ctn) exhibited elevated phosphorylation upon a tetracycline-mediated decrease in the SHP-1 level.	tet	99-111	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	123-128
10835420-6	2000	SHP-1 associated transiently with p120(ctn) in EGF-stimulated A431 cells stably transfected with a tetracycline-responsive SHP-1 expression construct, and p120(ctn) exhibited elevated phosphorylation upon a tetracycline-mediated decrease in the SHP-1 level.	tet	99-111	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	123-128
10835420-6	2000	SHP-1 associated transiently with p120(ctn) in EGF-stimulated A431 cells stably transfected with a tetracycline-responsive SHP-1 expression construct, and p120(ctn) exhibited elevated phosphorylation upon a tetracycline-mediated decrease in the SHP-1 level.	tet	207-219	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	0-5
10944108-1	2000	The reverse tetracycline-dependent transactivator system was employed in insulinoma INS-1 cells to achieve controlled inducible expression of hepatocyte nuclear factor-1 alpha (HNF1 alpha)-P291fsinsC, the most common mutation associated with subtype 3 of maturity-onset diabetes of the young (MODY3).	tet	12-24	HNF1 homeobox A	Rattus norvegicus	142-187
10925251-2	2000	Transduction of proliferating CD4+ T cells with a tetracycline-regulated retrovirus encoding for a dominant-interfering, degradation-resistant I-kappaBalpha (inhibitor of kappa B alpha factor) mutant induced apoptosis.	tet	50-62	CD4 molecule	Homo sapiens	30-33
10925251-2	2000	Transduction of proliferating CD4+ T cells with a tetracycline-regulated retrovirus encoding for a dominant-interfering, degradation-resistant I-kappaBalpha (inhibitor of kappa B alpha factor) mutant induced apoptosis.	tet	50-62	NFKB inhibitor alpha	Homo sapiens	143-191
10954897-0	2000	Expression of wild-type and noncleavable Fas ligand by tetracycline-regulated adenoviral vectors to limit intimal hyperplasia in vascular lesions.	tet	55-67	Fas ligand	Rattus norvegicus	41-51
10982843-2	2000	Here, we show that tetracycline-regulated SSeCKS expression in NIH 3T3 cells induces G(1) arrest marked by extracellular signal-regulated kinase 2-dependent decreases in cyclin D1 expression and pRb phosphorylation.	tet	19-31	mitogen-activated protein kinase 1	Mus musculus	107-146
10982843-2	2000	Here, we show that tetracycline-regulated SSeCKS expression in NIH 3T3 cells induces G(1) arrest marked by extracellular signal-regulated kinase 2-dependent decreases in cyclin D1 expression and pRb phosphorylation.	tet	19-31	cyclin D1	Mus musculus	170-179
10982843-2	2000	Here, we show that tetracycline-regulated SSeCKS expression in NIH 3T3 cells induces G(1) arrest marked by extracellular signal-regulated kinase 2-dependent decreases in cyclin D1 expression and pRb phosphorylation.	tet	19-31	RB transcriptional corepressor 1	Mus musculus	195-198
10903871-4	2000	Here, we show that the antibiotic tetracycline: (i) binds to amyloid fibrils generated by synthetic peptides corresponding to residues 106-126 and 82-146 of human PrP; (ii) hinders assembly of these peptides into amyloid fibrils; (iii) reverts the protease resistance of PrP peptide aggregates and PrP(Sc) extracted from brain tissue of patients with Creutzfeldt-Jakob disease; (iv) prevents neuronal death and astrocyte proliferation induced by PrP peptides in vitro.	tet	34-46	prion protein	Homo sapiens	271-274
10903871-4	2000	Here, we show that the antibiotic tetracycline: (i) binds to amyloid fibrils generated by synthetic peptides corresponding to residues 106-126 and 82-146 of human PrP; (ii) hinders assembly of these peptides into amyloid fibrils; (iii) reverts the protease resistance of PrP peptide aggregates and PrP(Sc) extracted from brain tissue of patients with Creutzfeldt-Jakob disease; (iv) prevents neuronal death and astrocyte proliferation induced by PrP peptides in vitro.	tet	34-46	prion protein	Homo sapiens	271-274
10903871-0	2000	Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro.	tet	0-12	prion protein	Homo sapiens	54-57
10903871-0	2000	Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro.	tet	0-12	prion protein	Homo sapiens	71-74
10903871-4	2000	Here, we show that the antibiotic tetracycline: (i) binds to amyloid fibrils generated by synthetic peptides corresponding to residues 106-126 and 82-146 of human PrP; (ii) hinders assembly of these peptides into amyloid fibrils; (iii) reverts the protease resistance of PrP peptide aggregates and PrP(Sc) extracted from brain tissue of patients with Creutzfeldt-Jakob disease; (iv) prevents neuronal death and astrocyte proliferation induced by PrP peptides in vitro.	tet	34-46	prion protein	Homo sapiens	271-274
10903871-4	2000	Here, we show that the antibiotic tetracycline: (i) binds to amyloid fibrils generated by synthetic peptides corresponding to residues 106-126 and 82-146 of human PrP; (ii) hinders assembly of these peptides into amyloid fibrils; (iii) reverts the protease resistance of PrP peptide aggregates and PrP(Sc) extracted from brain tissue of patients with Creutzfeldt-Jakob disease; (iv) prevents neuronal death and astrocyte proliferation induced by PrP peptides in vitro.	tet	34-46	prion protein	Homo sapiens	163-166
10903871-5	2000	NMR spectroscopy revealed several through-space interactions between aromatic protons of tetracycline and side-chain protons of Ala(117-119), Val(121-122) and Leu(125) of PrP 106-126.	tet	89-101	prion protein	Homo sapiens	171-174
10903871-6	2000	These properties make tetracycline a prototype of compounds with the potential of inactivating the pathogenic forms of PrP.	tet	22-34	prion protein	Homo sapiens	119-122
10890889-2	2000	One component of the system is the tetracycline-controlled transactivator gene under the control of the fat body and female-specific transcription enhancer from the yolk protein 1 gene.	tet	35-47	Yolk protein 1	Drosophila melanogaster	165-179
23105246-1	2000	Genomic DNA from a clinical isolate ofMycobacterium avium-intracellulare complex was purified and cloned in PBR 322 at the tetracycline resistance site using Bam HI restriction enzyme.	tet	123-135	translocator protein	Homo sapiens	108-111
10866663-1	2000	We have employed gene targeting coupled with conditional expression to construct a chicken DT40 cell line in which a tetracycline (Tet)-repressible promoter is exclusively responsible for expression of cTAF(II)31, a histone-like TAF(II) residing in both the transcription factor TFIID and the histone acetylase complex PCAF/SAGA.	tet	117-129	lysine acetyltransferase 2B	Gallus gallus	319-323
10866663-1	2000	We have employed gene targeting coupled with conditional expression to construct a chicken DT40 cell line in which a tetracycline (Tet)-repressible promoter is exclusively responsible for expression of cTAF(II)31, a histone-like TAF(II) residing in both the transcription factor TFIID and the histone acetylase complex PCAF/SAGA.	tet	131-134	lysine acetyltransferase 2B	Gallus gallus	319-323
10770932-7	2000	To confirm the involvement of similar pathways induced by bFGF and DNA damage, we generated tetracycline-regulatable SK-N-MC clones expressing Cdc25C-S216A.	tet	92-104	fibroblast growth factor 2	Homo sapiens	58-62
10990266-1	2000	The role of two chaperone proteins, DnaK and the cooperating factor DnaJ, in Escherichia coli antibiotic susceptibility to three antibiotics (a beta-lactam, chloramphenicol, tetracycline) has been studied.	tet	174-186	DnaJ	Escherichia coli	68-72
10770932-7	2000	To confirm the involvement of similar pathways induced by bFGF and DNA damage, we generated tetracycline-regulatable SK-N-MC clones expressing Cdc25C-S216A.	tet	92-104	cell division cycle 25C	Homo sapiens	143-149
10748183-6	2000	Tetracycline inducible heavy chain gene expression was also increased by IFN treatment or TAP cotransfection, suggesting that IFN-induced TAP supports heavy chain maturation.	tet	0-12	interferon alpha 1	Homo sapiens	73-76
10864872-4	2000	Tetracycline-regulated transgenic mice expressing constitutively active Rac2 in T cells exhibited enhanced IFN-gamma production.	tet	0-12	Rac family small GTPase 2	Mus musculus	72-76
10864872-4	2000	Tetracycline-regulated transgenic mice expressing constitutively active Rac2 in T cells exhibited enhanced IFN-gamma production.	tet	0-12	interferon gamma	Mus musculus	107-116
10873444-4	2000	We found that DRB had a biphasic effect on T-cell receptor-beta (TCRbeta) transcripts driven by a tetracycline (tet)-responsive promoter in transfected HeLa cells.	tet	98-110	T cell receptor beta locus	Homo sapiens	65-72
10873444-4	2000	We found that DRB had a biphasic effect on T-cell receptor-beta (TCRbeta) transcripts driven by a tetracycline (tet)-responsive promoter in transfected HeLa cells.	tet	98-101	T cell receptor beta locus	Homo sapiens	65-72
10748183-6	2000	Tetracycline inducible heavy chain gene expression was also increased by IFN treatment or TAP cotransfection, suggesting that IFN-induced TAP supports heavy chain maturation.	tet	0-12	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	90-93
10748183-6	2000	Tetracycline inducible heavy chain gene expression was also increased by IFN treatment or TAP cotransfection, suggesting that IFN-induced TAP supports heavy chain maturation.	tet	0-12	interferon alpha 1	Homo sapiens	126-129
10748183-6	2000	Tetracycline inducible heavy chain gene expression was also increased by IFN treatment or TAP cotransfection, suggesting that IFN-induced TAP supports heavy chain maturation.	tet	0-12	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	138-141
10822280-5	2000	To bypass this problem, we generated stable keratinocyte cell lines that express mature human filaggrin using a tetracycline-inducible promoter system.	tet	112-124	filaggrin	Homo sapiens	94-103
10843386-3	2000	Here we demonstrate the ability of a tetracycline-based tissue-specific inducible Lck transgene to restore expansion of early thymocytes and maturation of single-positive cells in Lckneg mice upon induction with doxycycline.	tet	37-49	lymphocyte protein tyrosine kinase	Mus musculus	82-85
10748185-3	2000	Mouse fibroblasts that express N-JNK under tetracycline-off (tet-off) inducible promoter exhibited elevated expression of c-Jun, ATF2, and p53 upon tetracycline removal.	tet	43-55	mitogen-activated protein kinase 8	Mus musculus	33-36
10748185-3	2000	Mouse fibroblasts that express N-JNK under tetracycline-off (tet-off) inducible promoter exhibited elevated expression of c-Jun, ATF2, and p53 upon tetracycline removal.	tet	43-55	jun proto-oncogene	Mus musculus	122-127
10748185-3	2000	Mouse fibroblasts that express N-JNK under tetracycline-off (tet-off) inducible promoter exhibited elevated expression of c-Jun, ATF2, and p53 upon tetracycline removal.	tet	43-55	activating transcription factor 2	Mus musculus	129-133
10748185-3	2000	Mouse fibroblasts that express N-JNK under tetracycline-off (tet-off) inducible promoter exhibited elevated expression of c-Jun, ATF2, and p53 upon tetracycline removal.	tet	43-55	transformation related protein 53, pseudogene	Mus musculus	139-142
10748185-3	2000	Mouse fibroblasts that express N-JNK under tetracycline-off (tet-off) inducible promoter exhibited elevated expression of c-Jun, ATF2, and p53 upon tetracycline removal.	tet	148-160	mitogen-activated protein kinase 8	Mus musculus	33-36
10748185-3	2000	Mouse fibroblasts that express N-JNK under tetracycline-off (tet-off) inducible promoter exhibited elevated expression of c-Jun, ATF2, and p53 upon tetracycline removal.	tet	148-160	jun proto-oncogene	Mus musculus	122-127
10748185-3	2000	Mouse fibroblasts that express N-JNK under tetracycline-off (tet-off) inducible promoter exhibited elevated expression of c-Jun, ATF2, and p53 upon tetracycline removal.	tet	148-160	transformation related protein 53, pseudogene	Mus musculus	139-142
10773818-3	2000	Here we describe an inducible fibroblast line that expresses Bax when tetracycline is withdrawn; the resulting apoptosis can be blocked by the caspase inhibitor zVAD-fmk.	tet	70-82	BCL2 associated X, apoptosis regulator	Homo sapiens	61-64
10778981-2	2000	To investigate the relationship between E2F-1 and drug sensitivity in detail, we established human osteosarcoma U-20S-TA cells expressing full-length E2F-1/ DP-1 under the control of a tetracycline-responsive promoter, designated UE1DP-1 cells.	tet	185-197	E2F transcription factor 1	Homo sapiens	40-45
10778981-2	2000	To investigate the relationship between E2F-1 and drug sensitivity in detail, we established human osteosarcoma U-20S-TA cells expressing full-length E2F-1/ DP-1 under the control of a tetracycline-responsive promoter, designated UE1DP-1 cells.	tet	185-197	E2F transcription factor 1	Homo sapiens	150-155
10826494-2	2000	New bi- and tricistronic expression vectors (pNRTIS-21 and pNRTIS-33, respectively) based on the tetracycline system were constructed and employed to generate stable cell lines with inducible expression of SHP-1.	tet	97-109	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	206-211
10807123-15	2000	Osteocalcin production was reduced on all dentin surfaces, but the greatest reduction was found on the TCN-treated surface.	tet	103-106	bone gamma-carboxyglutamate protein	Homo sapiens	0-11
10729144-0	2000	Elucidating the essential role of the A14 phosphoprotein in vaccinia virus morphogenesis: construction and characterization of a tetracycline-inducible recombinant.	tet	129-141	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	38-41
10729144-6	2000	To enable a genetic analysis of A14"s function during the viral life cycle, we have adopted the regulatory components of the tetracycline (TET) operon and created new reagents for the construction of TET-inducible vaccinia virus recombinants.	tet	200-203	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	32-35
10729144-8	2000	We constructed a TET-inducible recombinant for the A14 gene, vindA14.	tet	17-20	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	51-54
10729153-9	2000	By using a tetracycline-inducible system, we show that induction of IRF-3(5D) alone is sufficient to induce apoptosis in human embryonic kidney 293 and human Jurkat T cells as measured by DNA laddering, terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling assay, and analysis of DNA content by flow cytometry.	tet	11-23	interferon regulatory factor 3	Homo sapiens	68-73
10777218-8	2000	Furthermore, we have established several cell lines derived from H1299 lung carcinoma and U118 glioma cells that inducibly express Dkk-1 under a tetracycline-regulated promoter.	tet	145-157	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	131-136
10706883-2	2000	A truncated form of STAT5B (triangle upSTAT5; aa, 1-683) that lacks tyrosine 699 and the transcriptional activation domain was introduced into Ba/F3p210 cells under the control of a tetracycline-inducible promoter.	tet	182-194	signal transducer and activator of transcription 5B	Mus musculus	20-26
10706883-3	2000	Treatment of these cells with doxycycline, a tetracycline analogue, induced expression of triangle upSTAT5 and inhibited STAT5-dependent transcription.	tet	45-57	signal transducer and activator of transcription 5A	Mus musculus	101-106
10706883-7	2000	These results indicate that high-level expression of triangle upSTAT5, as achieved here by using a tetracycline-inducible promoter, inhibits STAT5 activity, reduces the growth rate of Ba/F3p210 cells by inhibiting viability, and results in increased sensitivity to chemotherapeutic drugs.	tet	99-111	signal transducer and activator of transcription 5A	Mus musculus	64-69
10825190-1	2000	A tetracycline-regulated reporter system was used to investigate the regulation of cyclooxygenase 2 (Cox-2) mRNA stability by the mitogen-activated protein kinase (MAPK) p38 signaling cascade.	tet	2-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-99
10825190-1	2000	A tetracycline-regulated reporter system was used to investigate the regulation of cyclooxygenase 2 (Cox-2) mRNA stability by the mitogen-activated protein kinase (MAPK) p38 signaling cascade.	tet	2-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-106
10825190-1	2000	A tetracycline-regulated reporter system was used to investigate the regulation of cyclooxygenase 2 (Cox-2) mRNA stability by the mitogen-activated protein kinase (MAPK) p38 signaling cascade.	tet	2-14	mitogen-activated protein kinase 14	Homo sapiens	170-173
10851075-2	2000	We have established TetRgr cell lines in which expression of Rgr can be inhibited by the presence of tetracycline in the medium.	tet	101-113	retinal G protein coupled receptor	Homo sapiens	23-26
10825149-3	2000	We took advantage of a tetracycline-regulated gene expression system to control the expression of RB2/p130 in JC virus-induced hamster brain tumor cells to study in vivo the molecular mechanisms used by pRb2/p130 to elicit its growth-suppressive function.	tet	23-35	RB transcriptional corepressor like 2	Homo sapiens	98-101
10825149-3	2000	We took advantage of a tetracycline-regulated gene expression system to control the expression of RB2/p130 in JC virus-induced hamster brain tumor cells to study in vivo the molecular mechanisms used by pRb2/p130 to elicit its growth-suppressive function.	tet	23-35	RB transcriptional corepressor like 2	Homo sapiens	102-106
10825149-3	2000	We took advantage of a tetracycline-regulated gene expression system to control the expression of RB2/p130 in JC virus-induced hamster brain tumor cells to study in vivo the molecular mechanisms used by pRb2/p130 to elicit its growth-suppressive function.	tet	23-35	proline rich protein BstNI subfamily 2	Homo sapiens	203-207
10825149-3	2000	We took advantage of a tetracycline-regulated gene expression system to control the expression of RB2/p130 in JC virus-induced hamster brain tumor cells to study in vivo the molecular mechanisms used by pRb2/p130 to elicit its growth-suppressive function.	tet	23-35	RB transcriptional corepressor like 2	Homo sapiens	208-212
10745191-5	2000	Tetracycline-regulated co-expression of a ST3Gal I fragment, cloned in the antisense orientation, and of C2GnT cDNA resulted in inhibition of the ST3Gal I enzymatic activity and increase in C2GnT activity which varied depending on the extent of tetracycline reduction in the cell culture medium.	tet	0-12	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	105-110
10745191-5	2000	Tetracycline-regulated co-expression of a ST3Gal I fragment, cloned in the antisense orientation, and of C2GnT cDNA resulted in inhibition of the ST3Gal I enzymatic activity and increase in C2GnT activity which varied depending on the extent of tetracycline reduction in the cell culture medium.	tet	0-12	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	190-195
10745191-5	2000	Tetracycline-regulated co-expression of a ST3Gal I fragment, cloned in the antisense orientation, and of C2GnT cDNA resulted in inhibition of the ST3Gal I enzymatic activity and increase in C2GnT activity which varied depending on the extent of tetracycline reduction in the cell culture medium.	tet	245-257	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	105-110
10745191-5	2000	Tetracycline-regulated co-expression of a ST3Gal I fragment, cloned in the antisense orientation, and of C2GnT cDNA resulted in inhibition of the ST3Gal I enzymatic activity and increase in C2GnT activity which varied depending on the extent of tetracycline reduction in the cell culture medium.	tet	245-257	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	190-195
10837918-3	2000	To study the mechanism by which this transient Wnt-1 expression inhibits differentiation we have constructed PC12 pheochromocytoma cells in which Wnt-1 expression levels were controlled by use of a tetracycline-responsive transactivator.	tet	198-210	Wnt family member 1	Rattus norvegicus	47-52
10837918-3	2000	To study the mechanism by which this transient Wnt-1 expression inhibits differentiation we have constructed PC12 pheochromocytoma cells in which Wnt-1 expression levels were controlled by use of a tetracycline-responsive transactivator.	tet	198-210	Wnt family member 1	Rattus norvegicus	146-151
10837918-4	2000	Induction of Wnt-1 expression by tetracycline withdrawal was followed by activation of the Wnt-1 signalling pathway as shown by activation of the Lef-1/Tcf transcription factor.	tet	33-45	Wnt family member 1	Rattus norvegicus	13-18
10843379-2	2000	By adapting the tetracycline-regulated gene transcription system, we generated a murine model where islet-specific expression of TNFalpha could be repressed/derepressed within 48 hr following introduction/removal of tetracycline in the drinking water.	tet	16-28	tumor necrosis factor	Mus musculus	129-137
10843379-2	2000	By adapting the tetracycline-regulated gene transcription system, we generated a murine model where islet-specific expression of TNFalpha could be repressed/derepressed within 48 hr following introduction/removal of tetracycline in the drinking water.	tet	216-228	tumor necrosis factor	Mus musculus	129-137
10779750-2	2000	To study the functional relevance of the IFN-gamma-inducible proteasome subunits low molecular mass protein 2 (LMP2), LMP7, and mouse embryonal cell (MEC) ligand 1 in Ag processing and concomitantly that of immunoproteasomes, we established the tetracycline-regulated mouse cell line MEC217, allowing the titrable formation of immunoproteasomes.	tet	245-257	interferon gamma	Mus musculus	41-50
10797532-1	2000	We have engineered conditionally-immortalized mouse astrocytes to express beta-galactosidase or GAD(65) in a tetracycline-controlled fashion.	tet	109-121	galactosidase, beta 1	Mus musculus	74-92
10797532-1	2000	We have engineered conditionally-immortalized mouse astrocytes to express beta-galactosidase or GAD(65) in a tetracycline-controlled fashion.	tet	109-121	glutamic acid decarboxylase 2	Mus musculus	96-103
10797532-3	2000	Using the BASlinbetagal cell line, we showed a dramatic regulation of beta-galactosidase expression by tetracycline.	tet	103-115	galactosidase, beta 1	Mus musculus	70-88
10797532-4	2000	The BASlin65 cell line showed functional GAD(65) enzymatic activity and GABA production, both of which were suppressed by growth in the presence of tetracycline.	tet	148-160	glutamic acid decarboxylase 2	Mus musculus	41-48
10773449-0	2000	The p65 domain from NF-kappaB is an efficient human activator in the tetracycline-regulatable gene expression system.	tet	69-81	RELA proto-oncogene, NF-kB subunit	Homo sapiens	4-7
10773449-0	2000	The p65 domain from NF-kappaB is an efficient human activator in the tetracycline-regulatable gene expression system.	tet	69-81	nuclear factor kappa B subunit 1	Homo sapiens	20-29
10740230-3	2000	This experimental system creates an "on/off" situation in which GFAP expression is suppressed by tetracycline.	tet	97-109	glial fibrillary acidic protein	Homo sapiens	64-68
10688900-2	2000	In this study we examined the effect of expression of MLL-AF9 on differentiation of the monoblastic U937 cell line by using a tetracycline-inducible expression system.	tet	126-138	lysine methyltransferase 2A	Homo sapiens	54-57
10713068-4	2000	To reconstitute faithfully the normal AT(1)-R mRNA regulatory environment, tetracycline-suppressible promoters drive highly accurate recombinant AT(1)-R mRNA mimics in vascular smooth muscle cells that co-express an endogenous AT(1)-R mRNA.	tet	75-87	angiotensin II receptor type 1	Homo sapiens	145-152
10713068-4	2000	To reconstitute faithfully the normal AT(1)-R mRNA regulatory environment, tetracycline-suppressible promoters drive highly accurate recombinant AT(1)-R mRNA mimics in vascular smooth muscle cells that co-express an endogenous AT(1)-R mRNA.	tet	75-87	angiotensin II receptor type 1	Homo sapiens	145-152
10688900-2	2000	In this study we examined the effect of expression of MLL-AF9 on differentiation of the monoblastic U937 cell line by using a tetracycline-inducible expression system.	tet	126-138	MLLT3 super elongation complex subunit	Homo sapiens	58-61
10666260-0	2000	Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines.	tet	122-134	KRAS proto-oncogene, GTPase	Homo sapiens	92-95
10724037-2	2000	Receptor-deficient Chinese hamster ovary (CHO) cells were transfected with a PiT-2 construct that could be induced by the removal of tetracycline.	tet	133-145	sodium-dependent phosphate transporter 2	Cricetulus griseus	77-82
10776921-8	2000	The MMP activities were differentially inhibited by derivatives of tetracycline.	tet	67-79	matrix metallopeptidase 2	Homo sapiens	4-7
10669749-7	2000	Blocking KAP expression by antisense KAP in a tetracycline-regulatable system results in a reduced population of S-phase cells and reduced Cdk2 kinase activity.	tet	46-58	cyclin dependent kinase inhibitor 3	Homo sapiens	9-12
10669749-7	2000	Blocking KAP expression by antisense KAP in a tetracycline-regulatable system results in a reduced population of S-phase cells and reduced Cdk2 kinase activity.	tet	46-58	cyclin dependent kinase inhibitor 3	Homo sapiens	37-40
10669749-7	2000	Blocking KAP expression by antisense KAP in a tetracycline-regulatable system results in a reduced population of S-phase cells and reduced Cdk2 kinase activity.	tet	46-58	cyclin dependent kinase 2	Homo sapiens	139-143
10660616-2	2000	To understand the in vivo function of CBF, a dominant negative mutant of CBF-B subunit that inhibits DNA binding of wild type CBF was stably expressed in mouse fibroblast cells under control of tetracycline-responsive promoter.	tet	194-206	core binding factor beta	Mus musculus	73-78
10677527-6	2000	We utilized tetracycline-regulated expression of Bcr-Abl from a promoter engineered for robust expression in primitive stem cells through multilineage blood cell development in combination with the in vitro differentiation of embryonal stem cells into hematopoietic elements.	tet	12-24	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	49-56
10660616-2	2000	To understand the in vivo function of CBF, a dominant negative mutant of CBF-B subunit that inhibits DNA binding of wild type CBF was stably expressed in mouse fibroblast cells under control of tetracycline-responsive promoter.	tet	194-206	CCAAT/enhancer binding protein zeta	Mus musculus	73-76
10679776-0	2000	Neurite outgrowth can be modulated in vitro using a tetracycline-repressible gene therapy vector expressing human nerve growth factor.	tet	52-64	nerve growth factor	Homo sapiens	114-133
10666115-5	2000	Using the tetracycline-regulated expression system, we show here that conditional overexpression of HO-1 prevents tumor necrosis factor-alpha-induced apoptosis in murine L929 fibroblasts.	tet	10-22	heme oxygenase 1	Mus musculus	100-104
10666115-5	2000	Using the tetracycline-regulated expression system, we show here that conditional overexpression of HO-1 prevents tumor necrosis factor-alpha-induced apoptosis in murine L929 fibroblasts.	tet	10-22	tumor necrosis factor	Mus musculus	114-141
10679776-4	2000	In the present experiment, a tetracycline-regulatable gene expression system was generated to determine whether controllable release of nerve growth factor (NGF) and green fluorescent protein (GFP) from primary rat fibroblasts could modulate biological responses (neurite outgrowth) in vitro.	tet	29-41	nerve growth factor	Rattus norvegicus	136-155
10679776-5	2000	Using a tetracycline-repressible construct, it was found that NGF mRNA, NGF protein, and NGF-induced neurite outgrowth could be tightly regulated within a 24 hour period, and in a dose-dependent fashion, by exposure to the tetracycline analog doxycycline.	tet	8-20	nerve growth factor	Homo sapiens	62-65
10679776-5	2000	Using a tetracycline-repressible construct, it was found that NGF mRNA, NGF protein, and NGF-induced neurite outgrowth could be tightly regulated within a 24 hour period, and in a dose-dependent fashion, by exposure to the tetracycline analog doxycycline.	tet	8-20	nerve growth factor	Homo sapiens	72-75
10679776-5	2000	Using a tetracycline-repressible construct, it was found that NGF mRNA, NGF protein, and NGF-induced neurite outgrowth could be tightly regulated within a 24 hour period, and in a dose-dependent fashion, by exposure to the tetracycline analog doxycycline.	tet	8-20	nerve growth factor	Homo sapiens	72-75
10679776-5	2000	Using a tetracycline-repressible construct, it was found that NGF mRNA, NGF protein, and NGF-induced neurite outgrowth could be tightly regulated within a 24 hour period, and in a dose-dependent fashion, by exposure to the tetracycline analog doxycycline.	tet	223-235	nerve growth factor	Homo sapiens	62-65
10637279-0	2000	Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules.	tet	0-12	CD4 antigen	Mus musculus	39-42
10721718-0	2000	Positive tetracycline control of expression of p15INK4B from an Epstein-Barr autonomous plasmid in a human melanoma cell line.	tet	9-21	cyclin dependent kinase inhibitor 2B	Homo sapiens	47-55
10721718-6	2000	We demonstrate that this system enabled efficient, and reasonably uniform, induction of p15INK4B expression in a human melanoma cell line exposed to the tetracycline derivative, doxycycline.	tet	153-165	cyclin dependent kinase inhibitor 2B	Homo sapiens	88-96
10637279-3	2000	This resulted in tet-responsive display of cell surface E complexes, positive selection of CD4(+)8(-) thymocytes, and generation of a CD4(+) T cell compartment in a class II-barren periphery.	tet	17-20	CD4 antigen	Mus musculus	134-137
11043381-2	2000	To study the role of Raf in transformation we transduced Rat-1 cells with a tetracycline-regulatable retroviral vector encoding the constitutively active oncogenic C-terminal fragment of the human Raf-1 protein.	tet	76-88	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	197-202
10678368-0	2000	Tetracycline-induced expression of an anti-c-Myb single-chain antibody and its inhibitory effect on proliferation of the human leukemia cell line K562.	tet	0-12	MYB proto-oncogene, transcription factor	Homo sapiens	43-48
10883268-1	2000	Sequence of MSP1-31 of Plasmodium falciparum was constructed into eukaryotic expression vector pTRE, which could be repressed by tetracycline (Tc) and resulted in recombinant plasmid pTRE-31.	tet	129-141	salivary protein electrophoretic 1, regulator	Mus musculus	12-16
10883268-1	2000	Sequence of MSP1-31 of Plasmodium falciparum was constructed into eukaryotic expression vector pTRE, which could be repressed by tetracycline (Tc) and resulted in recombinant plasmid pTRE-31.	tet	143-145	salivary protein electrophoretic 1, regulator	Mus musculus	12-16
10647278-4	1999	After introducing the therapy with demeclocycline, a tetracycline type antibiotic that inhibits the renal action of antidiuretic hormone, serum sodium levels began to rise gradually, and the urinary sodium excretion slowly decreased.	tet	53-65	arginine vasopressin	Homo sapiens	116-136
10572178-0	1999	Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells.	tet	166-178	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	17-26
10590245-3	1999	Fischer rat SMCs were stably transfected with a cDNA for rat MMP-9 under the control of a tetracycline-regulatable promoter.	tet	90-102	matrix metallopeptidase 9	Rattus norvegicus	61-66
10588737-2	1999	A modified tetracycline-inducible system was established to search for transcripts that were activated soon after p53 induction.	tet	11-23	tumor protein p53	Homo sapiens	114-117
10591209-3	1999	To determine when EDNRB signalling is required during embryogenesis, we have exploited the tetracycline-inducible system to generate strains of mice in which the endogenous Ednrb locus is under the control of the tetracycline-dependant transactivators tTa or rtTA.	tet	213-225	endothelin receptor type B	Mus musculus	18-23
10624772-6	1999	Furthermore, IL-8, Gro and MCP-1 concentrations decreased between 24 and 72 h. Immunocytochemistry indicated expression of IL-8 by pleural mesothelial cells 24 h, but not 72 h, following TCN administration.	tet	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
10590068-6	1999	This effect was directly due to BCR/ABL, because Ba/F3 cells, in which the expression of BCR/ABL could be regulated by a tetracycline-inducible promoter, also had reduced chemotaxis to SDF-1alpha when BCR/ABL was induced.	tet	121-133	BCR activator of RhoGEF and GTPase	Mus musculus	32-39
10590068-6	1999	This effect was directly due to BCR/ABL, because Ba/F3 cells, in which the expression of BCR/ABL could be regulated by a tetracycline-inducible promoter, also had reduced chemotaxis to SDF-1alpha when BCR/ABL was induced.	tet	121-133	BCR activator of RhoGEF and GTPase	Mus musculus	89-96
10590068-6	1999	This effect was directly due to BCR/ABL, because Ba/F3 cells, in which the expression of BCR/ABL could be regulated by a tetracycline-inducible promoter, also had reduced chemotaxis to SDF-1alpha when BCR/ABL was induced.	tet	121-133	BCR activator of RhoGEF and GTPase	Mus musculus	89-96
10606248-1	1999	Using a tetracycline-regulated expression system, we have shown that expression of bcl-X(s) is sufficient to induce acute cell death in 3T3 cells, and that the manner in which these cells die is both morphologically and biochemically different from Fas/CD95-induced apoptosis.	tet	8-20	BCL2-like 1	Mus musculus	83-88
10606248-1	1999	Using a tetracycline-regulated expression system, we have shown that expression of bcl-X(s) is sufficient to induce acute cell death in 3T3 cells, and that the manner in which these cells die is both morphologically and biochemically different from Fas/CD95-induced apoptosis.	tet	8-20	Fas (TNF receptor superfamily member 6)	Mus musculus	253-257
10624772-6	1999	Furthermore, IL-8, Gro and MCP-1 concentrations decreased between 24 and 72 h. Immunocytochemistry indicated expression of IL-8 by pleural mesothelial cells 24 h, but not 72 h, following TCN administration.	tet	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
10624772-7	1999	The data suggest that local elaboration of interleukin-8 and growth-related protein, in part of mesothelial origin, may influence neutrophil recruitment in tetracycline-induced pleuritis.	tet	156-168	C-X-C motif chemokine ligand 8	Homo sapiens	43-56
10506583-3	1999	To explain how induction of HO-1 results in protection against oxygen toxicity, hamster fibroblasts (HA-1) were stably transfected with a tetracycline response plasmid containing the full-length rat HO-1 cDNA construct to allow for regulation of gene expression by varying concentrations of doxycycline (Dox).	tet	138-150	heme oxygenase 1	Rattus norvegicus	28-32
10544215-1	1999	Using a cytochemical approach, we examined the role of tissue transglutaminase (tTgase, Type II) in the incorporation of latent TGF-beta binding protein-1 (LTBP-1) in the extracellular matrix of Swiss 3T3 fibroblasts in which tTgase expression can be modulated through a tetracycline-controlled promoter.	tet	271-283	latent transforming growth factor beta binding protein 1	Homo sapiens	156-162
10579933-8	1999	We describe application of the tetracycline regulatory system to inducible control of a glucocorticoid receptor (GR)/GFP chimera.	tet	31-43	nuclear receptor subfamily 3 group C member 1	Homo sapiens	88-111
10579933-8	1999	We describe application of the tetracycline regulatory system to inducible control of a glucocorticoid receptor (GR)/GFP chimera.	tet	31-43	nuclear receptor subfamily 3 group C member 1	Homo sapiens	113-115
10523635-6	1999	Ba/F3 cells in which expression of BCR/ABL was under the control of a tetracycline-inducible promoter showed rapid loss of p145 SHIP, coincident with induction of BCR/ABL expression.	tet	70-82	BCR activator of RhoGEF and GTPase	Mus musculus	35-42
10523635-6	1999	Ba/F3 cells in which expression of BCR/ABL was under the control of a tetracycline-inducible promoter showed rapid loss of p145 SHIP, coincident with induction of BCR/ABL expression.	tet	70-82	inositol polyphosphate-5-phosphatase D	Mus musculus	128-132
10523635-6	1999	Ba/F3 cells in which expression of BCR/ABL was under the control of a tetracycline-inducible promoter showed rapid loss of p145 SHIP, coincident with induction of BCR/ABL expression.	tet	70-82	BCR activator of RhoGEF and GTPase	Mus musculus	163-170
10531402-2	1999	When cells were grown in media containing normal concentrations (10%) of serum, induction of p53 by tetracycline withdrawal resulted in an 8-fold decrease in sensitivity to CP.	tet	100-112	tumor protein p53	Homo sapiens	93-96
10551775-10	1999	Overexpression of p57Kip2 using HeLa cells stably transfected with a tetracycline-inducible vector showed that p57Kip2 is sufficient to reconstitute an antiproliferative effect similar to that seen in DEX-treated cells.	tet	69-81	cyclin dependent kinase inhibitor 1C	Homo sapiens	18-25
10551775-10	1999	Overexpression of p57Kip2 using HeLa cells stably transfected with a tetracycline-inducible vector showed that p57Kip2 is sufficient to reconstitute an antiproliferative effect similar to that seen in DEX-treated cells.	tet	69-81	cyclin dependent kinase inhibitor 1C	Homo sapiens	111-118
10551775-11	1999	Selective p57Kip2 expression by the tetracycline analog doxycycline to levels comparable to those observed on DEX induction resulted in a 1.7-fold increase in the doubling time and a shift of HeLa cells to the G1 phase as well as a decrease in CDK2 activity.	tet	36-48	cyclin dependent kinase inhibitor 1C	Homo sapiens	10-17
10521420-4	1999	This mechanism was investigated by expressing a cat-1 mRNA from a tetracycline-regulated promoter.	tet	66-78	solute carrier family 7 member 1	Homo sapiens	48-53
10571078-1	1999	A transfectant HeLa cell clone expressing HFE under the control of a tetracycline-repressible promoter was generated.	tet	69-81	homeostatic iron regulator	Homo sapiens	42-45
10518586-4	1999	We describe the use of an adenovirus vector encoding human tyrosine hydroxylase (TH) 1 under the negative control of the tetracycline-sensitive gene regulatory system for direct injection into the dopamine-depleted striatum of a rat model of Parkinson"s disease.	tet	121-133	negative elongation factor complex member C/D	Homo sapiens	59-86
10517151-2	1999	Tetracycline has been determined in human serum samples by a combination of: (1) synchronous fluorescence spectra of whole sera treated with Mg2+, and (2) the multivariate calibration methods of partial least-squares (PLS-1) and a variant of the recently introduced hybrid linear analysis (HLA), which does not require the knowledge of pure-component spectra.	tet	0-12	plastin 1	Homo sapiens	218-223
10497010-4	1999	The anti-c-kit ribozyme was put under the control of a tetracycline-inducible two-plasmid system of expression.	tet	55-67	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	9-14
10497010-5	1999	Incomplete inhibition of Kit expression was observed when transcription of the ribozyme was allowed by the absence of tetracycline, but not when tetracycline was present.	tet	118-130	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	25-28
10562283-3	1999	We show that p73 isoforms, p73alpha and p73beta, can each induce permanent growth arrest with markers of replicative senescence when overexpressed in a tetracycline-regulatable manner in human cancer cells lacking functional p53.	tet	152-164	tumor protein p73	Homo sapiens	13-16
10551859-3	1999	In support of the biological significance of this interaction, we found that the complex of BRCA2 and Rad51 in breast cancer MCF-7 cells was diminished upon conditional expression of a wild-type, but not a mutated, BRC4 repeat using the tetracycline-inducible system.	tet	237-249	BRCA2 DNA repair associated	Homo sapiens	92-97
10551859-3	1999	In support of the biological significance of this interaction, we found that the complex of BRCA2 and Rad51 in breast cancer MCF-7 cells was diminished upon conditional expression of a wild-type, but not a mutated, BRC4 repeat using the tetracycline-inducible system.	tet	237-249	RAD51 recombinase	Homo sapiens	102-107
10541865-9	1999	To facilitate further research into p16/p15 effects, three cell lines with conditional, tetracycline-controlled p16 expression were established.	tet	88-100	cyclin dependent kinase inhibitor 2A	Homo sapiens	112-115
10544182-3	1999	Forced G0/G1 arrest by tetracycline-regulated expression of transgenic p16/INK4A protected the cells from butyrate-induced cell death without affecting the extent of histone hyperacetylation, suggesting that the latter may be necessary, but not sufficient, for cell death induction.	tet	23-35	cyclin dependent kinase inhibitor 2A	Homo sapiens	71-74
10544182-3	1999	Forced G0/G1 arrest by tetracycline-regulated expression of transgenic p16/INK4A protected the cells from butyrate-induced cell death without affecting the extent of histone hyperacetylation, suggesting that the latter may be necessary, but not sufficient, for cell death induction.	tet	23-35	cyclin dependent kinase inhibitor 2A	Homo sapiens	75-80
10544182-7	1999	On the contrary, tetracycline-induced transgenic c-myc sensitized stably transfected CCRF-CEM derivatives to butyrate-induced cell death.	tet	17-29	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	49-54
10534339-5	1999	We previously reported that VEGF tightly regulated murine HCC development, based on the results of a study using a retroviral tetracycline-regulated (Retro-Tet) gene expression system.	tet	126-138	vascular endothelial growth factor A	Mus musculus	28-32
10534339-6	1999	This system allows VEGF gene expression to be manipulated in vivo by providing tetracycline in the drinking water.	tet	79-91	vascular endothelial growth factor A	Mus musculus	19-23
10488126-1	1999	We have constructed tetracycline-responsive dhfr minigenes and transferred them to a Chinese hamster ovary cell DHFR-deficient deletion mutant to obtained cells in which dhfr transcription can be repressed by tetracycline (tet-off).	tet	20-32	dihydrofolate reductase	Cricetulus griseus	44-48
10488126-1	1999	We have constructed tetracycline-responsive dhfr minigenes and transferred them to a Chinese hamster ovary cell DHFR-deficient deletion mutant to obtained cells in which dhfr transcription can be repressed by tetracycline (tet-off).	tet	20-32	dihydrofolate reductase	Cricetulus griseus	170-174
10488126-1	1999	We have constructed tetracycline-responsive dhfr minigenes and transferred them to a Chinese hamster ovary cell DHFR-deficient deletion mutant to obtained cells in which dhfr transcription can be repressed by tetracycline (tet-off).	tet	20-32	dihydrofolate reductase	Cricetulus griseus	112-116
10488126-1	1999	We have constructed tetracycline-responsive dhfr minigenes and transferred them to a Chinese hamster ovary cell DHFR-deficient deletion mutant to obtained cells in which dhfr transcription can be repressed by tetracycline (tet-off).	tet	209-221	dihydrofolate reductase	Cricetulus griseus	44-48
10488126-1	1999	We have constructed tetracycline-responsive dhfr minigenes and transferred them to a Chinese hamster ovary cell DHFR-deficient deletion mutant to obtained cells in which dhfr transcription can be repressed by tetracycline (tet-off).	tet	209-221	dihydrofolate reductase	Cricetulus griseus	170-174
10498899-2	1999	To identify novel gene targets that may contribute to IRF-1 mediated activities, RNA fingerprinting was performed using NIH3T3 cells that inducibly express a hybrid form of IRF-1 under tetracycline regulated control.	tet	185-197	interferon regulatory factor 1	Mus musculus	173-178
10488126-2	1999	DHFR mRNA half-life measured after the repression of transcription by tetracycline in these transfectants is about 1.5 h, which is significantly shorter than previously reported.	tet	70-82	dihydrofolate reductase	Cricetulus griseus	0-4
10485491-5	1999	By delivering the VEGF gene within the self-contained tetracycline-regulated retroviral vector (Retro-Tet) into hepatocellular carcinoma (HCC) cells, we manipulated VEGF expression by providing tetracycline in the drinking water to assess the tumor kinetics mediated exclusively by VEGF.	tet	54-66	vascular endothelial growth factor A	Homo sapiens	18-22
10490843-5	1999	To directly address this issue, we used a tetracycline-regulated system in human U2OS osteosarcoma cells and thus found that BCL6 mediates growth suppression associated with impaired S phase progression and apoptosis.	tet	42-54	BCL6 transcription repressor	Homo sapiens	125-129
10473668-2	1999	To extend our understanding of the role of c-Jun in EC physiology, we have directed overexpression of c-Jun in human umbilical vein ECs by using a tetracycline-regulated adenoviral expression system.	tet	147-159	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-107
10473668-5	1999	Tetracycline can effectively shut off c-Jun overexpression and prevent EC apoptosis.	tet	0-12	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
10484323-16	1999	Furthermore, this effect could be alleviated by culturing infected cells in the presence of tetracycline, which prevents expression of the mutant rab11.	tet	92-104	ras-related protein Rab-11A	Oryctolagus cuniculus	146-151
10485491-5	1999	By delivering the VEGF gene within the self-contained tetracycline-regulated retroviral vector (Retro-Tet) into hepatocellular carcinoma (HCC) cells, we manipulated VEGF expression by providing tetracycline in the drinking water to assess the tumor kinetics mediated exclusively by VEGF.	tet	54-66	vascular endothelial growth factor A	Homo sapiens	165-169
10485491-5	1999	By delivering the VEGF gene within the self-contained tetracycline-regulated retroviral vector (Retro-Tet) into hepatocellular carcinoma (HCC) cells, we manipulated VEGF expression by providing tetracycline in the drinking water to assess the tumor kinetics mediated exclusively by VEGF.	tet	54-66	vascular endothelial growth factor A	Homo sapiens	165-169
10485491-5	1999	By delivering the VEGF gene within the self-contained tetracycline-regulated retroviral vector (Retro-Tet) into hepatocellular carcinoma (HCC) cells, we manipulated VEGF expression by providing tetracycline in the drinking water to assess the tumor kinetics mediated exclusively by VEGF.	tet	194-206	vascular endothelial growth factor A	Homo sapiens	18-22
10485491-5	1999	By delivering the VEGF gene within the self-contained tetracycline-regulated retroviral vector (Retro-Tet) into hepatocellular carcinoma (HCC) cells, we manipulated VEGF expression by providing tetracycline in the drinking water to assess the tumor kinetics mediated exclusively by VEGF.	tet	194-206	vascular endothelial growth factor A	Homo sapiens	165-169
10485491-5	1999	By delivering the VEGF gene within the self-contained tetracycline-regulated retroviral vector (Retro-Tet) into hepatocellular carcinoma (HCC) cells, we manipulated VEGF expression by providing tetracycline in the drinking water to assess the tumor kinetics mediated exclusively by VEGF.	tet	194-206	vascular endothelial growth factor A	Homo sapiens	165-169
10454561-7	1999	In vivo protection of both sites was inhibited by tetracycline-inducible TD-IkappaBalpha expression.	tet	50-62	NFKB inhibitor alpha	Homo sapiens	76-88
10510233-6	1999	The HeLa/C4 cells integrated with the Stx1B gene with a tetracycline-inducible promoter eventually produced cytoplasmic Stx1B, leading to DNA fragmentation on the addition of doxycycline.	tet	56-68	syntaxin 1B	Homo sapiens	38-43
10454561-4	1999	In previous studies, tetracycline-inducible expression of transdominant repressors of IkappaBalpha (TD-IkappaBalpha) progressively decreased endogenous IkappaBalpha protein levels.	tet	21-33	NFKB inhibitor alpha	Homo sapiens	86-98
10510233-6	1999	The HeLa/C4 cells integrated with the Stx1B gene with a tetracycline-inducible promoter eventually produced cytoplasmic Stx1B, leading to DNA fragmentation on the addition of doxycycline.	tet	56-68	syntaxin 1B	Homo sapiens	120-125
10454561-4	1999	In previous studies, tetracycline-inducible expression of transdominant repressors of IkappaBalpha (TD-IkappaBalpha) progressively decreased endogenous IkappaBalpha protein levels.	tet	21-33	NFKB inhibitor alpha	Homo sapiens	103-115
10454561-4	1999	In previous studies, tetracycline-inducible expression of transdominant repressors of IkappaBalpha (TD-IkappaBalpha) progressively decreased endogenous IkappaBalpha protein levels.	tet	21-33	NFKB inhibitor alpha	Homo sapiens	103-115
10438572-4	1999	Tetracycline analogues at concentrations that inhibited the production of MMP-2 but not MMP-9 were able to drastically inhibit migration of both mucosal and skin keratinocytes.	tet	0-12	matrix metallopeptidase 2	Homo sapiens	74-79
10448095-5	1999	Data presented here demonstrate that STAT1, STAT5A, and STAT5B, but not STAT3 and STAT6, were induced in a tetracycline-responsive manner during the differentiation of these engineered fibroblasts.	tet	107-119	signal transducer and activator of transcription 1	Homo sapiens	37-42
10446223-5	1999	Using tetracycline-regulated expression system, we showed that overexpression of Grb7 enhanced cell migration toward fibronectin, whereas overexpression of its SH2 domain alone inhibited cell migration.	tet	6-18	growth factor receptor bound protein 7	Mus musculus	81-85
10448095-5	1999	Data presented here demonstrate that STAT1, STAT5A, and STAT5B, but not STAT3 and STAT6, were induced in a tetracycline-responsive manner during the differentiation of these engineered fibroblasts.	tet	107-119	signal transducer and activator of transcription 5A	Homo sapiens	44-50
10448095-5	1999	Data presented here demonstrate that STAT1, STAT5A, and STAT5B, but not STAT3 and STAT6, were induced in a tetracycline-responsive manner during the differentiation of these engineered fibroblasts.	tet	107-119	signal transducer and activator of transcription 5B	Homo sapiens	56-62
10467407-5	1999	To address this controversy, we stably transfected the GC-sensitive human T-ALL cell line CEM-C7H2 with constructs allowing tetracycline-regulated expression of c-Myc.	tet	124-136	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	161-166
10467417-5	1999	Using a series of point and deletion mutants of p53 under the control of tetracycline-regulated promoter we show that certain mutants, like the wild type, protect cells at low levels but lead to apoptosis when overexpressed.	tet	73-85	tumor protein p53	Homo sapiens	48-51
10571408-5	1999	In comparison to the parental or U87T2 cell lines, the SPARC-transfected clones demonstrated: (1) morphological changes, (2) increased SPARC transcript and protein abundances that were down-regulated by the tetracycline analog doxycycline, (3) perinuclear localization of the transfected SPARC (consistent with reported localization of SPARC in normal cells in culture) and (4) altered adhesion and increased invasion as assessed by the spheroid confrontation assay.	tet	207-219	secreted protein acidic and cysteine rich	Homo sapiens	55-60
10425183-2	1999	We recently established a cell line (MIT-23) in which Vpr-induced cell cycle perturbation could be manipulated by a tetracycline promoter.	tet	116-128	Vpr	Human immunodeficiency virus 1	54-57
10415044-6	1999	TNF-alpha also inhibits CIITA mRNA accumulation and protein expression in a tetracycline-regulated system without affecting promoter activity.	tet	76-88	tumor necrosis factor	Homo sapiens	0-9
10415044-6	1999	TNF-alpha also inhibits CIITA mRNA accumulation and protein expression in a tetracycline-regulated system without affecting promoter activity.	tet	76-88	class II major histocompatibility complex transactivator	Homo sapiens	24-29
10415044-7	1999	CIITA mRNA, regulated by either IFN-gamma or tetracycline, was destabilized in the presence of TNF-alpha, suggesting that TNF-alpha utilizes a distinct mechanism to suppress MHC class II expression in HT1080 cells.	tet	45-57	class II major histocompatibility complex transactivator	Homo sapiens	0-5
10446804-4	1999	We then established a clone from C6 rat glioblastoma cells, where mouse CD24 (also called heat stable antigen) is under control of a tetracycline-responsive promoter.	tet	133-145	CD24a antigen	Mus musculus	72-76
10446804-4	1999	We then established a clone from C6 rat glioblastoma cells, where mouse CD24 (also called heat stable antigen) is under control of a tetracycline-responsive promoter.	tet	133-145	CD24a antigen	Mus musculus	90-109
10446804-5	1999	In the presence of tetracycline (1 microg/ml) CD24 was downregulated by 20-fold.	tet	19-31	CD24a antigen	Mus musculus	46-50
10446804-8	1999	We then transplanted the C6 clone into the striatum of nude mice and regulated CD24 expression via tetracycline in the drinking water (1 mg/ml).	tet	99-111	CD24a antigen	Mus musculus	79-83
10446804-9	1999	After 3 weeks, CD24 positive tumors of mice getting no tetracycline showed diffuse invasion of tumor cells in a brain area 10-fold larger than in CD24-suppressed tumors of mice receiving tetracycline.	tet	187-199	CD24a antigen	Mus musculus	15-19
10446804-9	1999	After 3 weeks, CD24 positive tumors of mice getting no tetracycline showed diffuse invasion of tumor cells in a brain area 10-fold larger than in CD24-suppressed tumors of mice receiving tetracycline.	tet	187-199	CD24a antigen	Mus musculus	146-150
10488335-2	1999	To examine this possibility, we have used the tetracycline regulatory system to generate transgenic mice that conditionally express the MYC protooncogene in hematopoietic cells.	tet	46-58	myelocytomatosis oncogene	Mus musculus	136-139
10428026-2	1999	Here we report that phenotypically normal mammary epithelial cells with tetracycline-regulated expression of MMP3/stromelysin-1 (Str1) form epithelial glandular structures in vivo without Str1 but form invasive mesenchymal-like tumors with Str1.	tet	72-84	matrix metallopeptidase 3	Mus musculus	109-127
10428026-2	1999	Here we report that phenotypically normal mammary epithelial cells with tetracycline-regulated expression of MMP3/stromelysin-1 (Str1) form epithelial glandular structures in vivo without Str1 but form invasive mesenchymal-like tumors with Str1.	tet	72-84	matrix metallopeptidase 3	Mus musculus	129-133
10373454-4	1999	Conditional SPA-1 overexpression in HeLa cells by tetracycline-regulative system suppressed Rap1 activation upon plating on dishes coated with fibronectin and resulted in the reduced adhesion.	tet	50-62	signal-induced proliferation-associated 1	Homo sapiens	12-17
10373454-4	1999	Conditional SPA-1 overexpression in HeLa cells by tetracycline-regulative system suppressed Rap1 activation upon plating on dishes coated with fibronectin and resulted in the reduced adhesion.	tet	50-62	RAP1A, member of RAS oncogene family	Homo sapiens	92-96
10364224-1	1999	The human band 4.1-related protein-tyrosine phosphatase PTPH1 was introduced into NIH3T3 cells under the control of a tetracycline-repressible promoter.	tet	118-130	protein tyrosine phosphatase non-receptor type 3	Homo sapiens	56-61
10383577-2	1999	Many of these MMPs are inhibited by tetracycline derivatives, which may have the potential to retard aneurysm growth.	tet	36-48	matrix metallopeptidase 9	Homo sapiens	14-18
10397808-4	1999	In this study, we have characterised a number of NS/0 subclones constitutively expressing different levels of E1B-19K, as well as several subclones in which the expression of E1B-19K was regulated by a tetracycline-controllable gene switch.	tet	202-214	small nucleolar RNA, H/ACA box 73a	Mus musculus	175-178
10383577-7	1999	At the highest concentration of tetracycline (100 microg/ml) median MMP-9 secretion was reduced from 27 to 5 ng/ml (P = 0.007) and median MCP-1 secretion was reduced from 50 to 10 ng/ml (P = 0.008).	tet	32-44	matrix metallopeptidase 9	Homo sapiens	68-73
10383577-7	1999	At the highest concentration of tetracycline (100 microg/ml) median MMP-9 secretion was reduced from 27 to 5 ng/ml (P = 0.007) and median MCP-1 secretion was reduced from 50 to 10 ng/ml (P = 0.008).	tet	32-44	C-C motif chemokine ligand 2	Homo sapiens	138-143
10443540-10	1999	One QAC resistant strain harbouring the smr gene showed resistance to ampicillin, penicillin, tetracycline, erythromycin and trimethoprim.	tet	94-106	multidrug resistance efflux protein Smr	Staphylococcus epidermidis	40-43
10343284-9	1999	In order to confirm the identity of the sequence, the V3/V1b receptor cDNA was cloned and stably expressed in CHO-AA8 Tet-Off cells under the control of tetracycline.	tet	153-165	arginine vasopressin receptor 1B	Mus musculus	54-60
10330171-8	1999	To test this model, we have employed the tetracycline-inducible system to increase eIF4E expression.	tet	41-53	eukaryotic translation initiation factor 4E	Homo sapiens	83-88
10330171-9	1999	Removal of tetracycline induced eIF4E expression up to fivefold over endogenous levels.	tet	11-23	eukaryotic translation initiation factor 4E	Homo sapiens	32-37
10347244-3	1999	In this study a recombinant AT1-R mRNA was synthesized in A7r5 vascular smooth muscle cells from a tetracycline-suppressible promoter using a retroviral vector system.	tet	99-111	angiotensin II receptor, type 1a	Rattus norvegicus	28-33
10347252-3	1999	Upon p21(waf1) induction by tetracycline withdrawal, we observed a reduced apoptotic response to paclitaxel with a 3- to 6-fold increase in IC50 values compared with that of cells not induced by p21(waf1).	tet	28-40	cyclin dependent kinase inhibitor 1A	Homo sapiens	5-8
10330410-4	1999	We established clonal tetracycline-regulated NIH-3T3 cell lines that inducibly express either wild-type Pak1, a kinase-dead, or constitutively-active forms of this enzyme, and examined the morphology, F-actin organization, and motility of these cells.	tet	22-34	p21 (RAC1) activated kinase 1	Mus musculus	104-108
10318865-5	1999	In these cells, removal of tetracycline from the growth medium stimulated coordinate expression of catalytic and regulatory CK2 subunits.	tet	27-39	casein kinase 2 alpha 2	Homo sapiens	124-127
10320774-3	1999	The KRAB domain from the human zinc finger protein KOX1 was combined with the DNA binding domain of the Escherichia coli tetracycline repressor (TetR).	tet	121-133	zinc finger protein 10	Homo sapiens	51-55
10329395-1	1999	We previously established a cell line called MIT-23 in which expression of the Vpr gene of human immunodeficiency virus 1 (HIV-1) can be controlled by the addition of tetracycline.	tet	167-179	Vpr	Human immunodeficiency virus 1	79-82
10224065-7	1999	To verify further the effect of IGFII on the cell cycle, we developed a Chinese hamster ovary (CHO) cell line with tetracycline-controlled IGFII expression.	tet	115-127	insulin-like growth factor 2	Mus musculus	32-37
10224065-7	1999	To verify further the effect of IGFII on the cell cycle, we developed a Chinese hamster ovary (CHO) cell line with tetracycline-controlled IGFII expression.	tet	115-127	insulin-like growth factor 2	Mus musculus	139-144
10361347-7	1999	CONCLUSION: TC rapidly penetrates AAA wall in vivo and inhibits MMP-9 and MCP-1 release by AAA explants.	tet	13-15	matrix metallopeptidase 9	Homo sapiens	65-70
10361347-7	1999	CONCLUSION: TC rapidly penetrates AAA wall in vivo and inhibits MMP-9 and MCP-1 release by AAA explants.	tet	13-15	C-C motif chemokine ligand 2	Homo sapiens	75-80
10217254-2	1999	In a search for the genes involved in this ganglioside-induced Neuro2a differentiation, we used a tetracycline-regulated GD3 synthase cDNA expression system combined with differential display PCRs to identify mRNAs that were differentially expressed at four representative time points during the process.	tet	98-110	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	121-133
10330992-0	1999	Endothelial expression of Fas ligand in transgenic rats under the temporal control of a tetracycline-inducible system.	tet	88-100	Fas ligand	Rattus norvegicus	26-36
10216184-1	1999	Tetracycline-regulated expression of recombinant nicotinic acetylcholine receptors (nAChR) composed of human alpha7 subunits is achieved in native nAChR-null SH-EP1 human epithelial cells.	tet	0-12	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	49-82
10216184-1	1999	Tetracycline-regulated expression of recombinant nicotinic acetylcholine receptors (nAChR) composed of human alpha7 subunits is achieved in native nAChR-null SH-EP1 human epithelial cells.	tet	0-12	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	84-89
10216184-1	1999	Tetracycline-regulated expression of recombinant nicotinic acetylcholine receptors (nAChR) composed of human alpha7 subunits is achieved in native nAChR-null SH-EP1 human epithelial cells.	tet	0-12	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	147-152
10191197-4	1999	In this study, we used a tetracycline-regulated inducible system in NIH3T3 cells to investigate the involvement of PKR in programmed cell death (apoptosis).	tet	25-37	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	115-118
10373454-4	1999	Conditional SPA-1 overexpression in HeLa cells by tetracycline-regulative system suppressed Rap1 activation upon plating on dishes coated with fibronectin and resulted in the reduced adhesion.	tet	50-62	fibronectin 1	Homo sapiens	143-154
10453476-4	1999	In the case of the tetracycline-regulated system, cell lines (both HeLa and U937) were generated that displayed tight regulation of Rev.	tet	19-31	Rev	Human immunodeficiency virus 1	132-135
10383577-6	1999	Tetracycline inhibited, in a concentration-dependent manner, both MMP-9 and MCP-1 secretion (P = 0.022 and P = 0.018 respectively), but did not alter hydroxyproline or IL-6 secretion.	tet	0-12	matrix metallopeptidase 9	Homo sapiens	66-71
10383577-6	1999	Tetracycline inhibited, in a concentration-dependent manner, both MMP-9 and MCP-1 secretion (P = 0.022 and P = 0.018 respectively), but did not alter hydroxyproline or IL-6 secretion.	tet	0-12	C-C motif chemokine ligand 2	Homo sapiens	76-81
10094923-2	1999	Since abnormality of mitotic checkpoint control provides a molecular basis of genomic instability, we studied the effects of Vpr on genetic integrity using a stable clone, named MIT-23, in which Vpr expression is controlled by the tetracycline-responsive promoter.	tet	231-243	Vpr	Human immunodeficiency virus 1	195-198
10101151-0	1999	Tightly regulated and inducible expression of rabbit CYP2E1 using a tetracycline-controlled expression system.	tet	68-80	cytochrome P450 2E1	Oryctolagus cuniculus	53-59
10101151-1	1999	A tetracycline (Tc)-controlled gene expression system that quantitatively controls gene expression in eukaryotic cells () was used to express cytochrome P-450 2E1 (CYP2E1) in HeLa cells in culture.	tet	2-14	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	142-162
10101151-1	1999	A tetracycline (Tc)-controlled gene expression system that quantitatively controls gene expression in eukaryotic cells () was used to express cytochrome P-450 2E1 (CYP2E1) in HeLa cells in culture.	tet	2-14	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	164-170
10101151-1	1999	A tetracycline (Tc)-controlled gene expression system that quantitatively controls gene expression in eukaryotic cells () was used to express cytochrome P-450 2E1 (CYP2E1) in HeLa cells in culture.	tet	16-18	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	142-162
10101151-1	1999	A tetracycline (Tc)-controlled gene expression system that quantitatively controls gene expression in eukaryotic cells () was used to express cytochrome P-450 2E1 (CYP2E1) in HeLa cells in culture.	tet	16-18	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	164-170
10101151-4	1999	There was a time-dependent induction of CYP2E1 after removal of Tc.	tet	64-66	cytochrome P450 2E1	Oryctolagus cuniculus	40-46
10101151-5	1999	In the absence of Tc, the enzyme was induced more than 100-fold and expressed about 18 pmol of CYP2E1/mg microsomal protein.	tet	18-20	cytochrome P450 2E1	Oryctolagus cuniculus	95-101
10101151-10	1999	Pulse-chase studies conducted 72 h after removal of Tc indicated a rapid turnover of CYP2E1 with a half-life of 3.9 h. Addition of the ligand, 4-methylpyrazole, and the suicide substrate, 1-aminobenzotrizole, decreased the degradation of CYP2E1.	tet	52-54	cytochrome P450 2E1	Oryctolagus cuniculus	85-91
10391141-2	1999	The application of both tetracycline inducible and improved differential display systems has allowed us to isolate a cDNA fragment differentially regulated by the expression of the TR2 orphan receptor.	tet	24-36	nuclear receptor subfamily 2 group C member 1	Homo sapiens	181-184
10085150-14	1999	Using a HeLa cell line in which the expression of HFE is controlled by tetracycline, we show that the expression of HFE reduces 55Fe uptake from Tf by 33% but does not affect the endocytic or exocytic rates of TfR cycling.	tet	71-83	homeostatic iron regulator	Homo sapiens	50-53
10207882-7	1999	We report the construction of a single adenovirus encoding human tyrosine hydroxylase 1 (hTH-1) under the negative control of the tetracycline-based gene regulatory system.	tet	130-142	tyrosine hydroxylase	Homo sapiens	65-85
10207882-7	1999	We report the construction of a single adenovirus encoding human tyrosine hydroxylase 1 (hTH-1) under the negative control of the tetracycline-based gene regulatory system.	tet	130-142	negative elongation factor complex member C/D	Homo sapiens	89-94
10085150-14	1999	Using a HeLa cell line in which the expression of HFE is controlled by tetracycline, we show that the expression of HFE reduces 55Fe uptake from Tf by 33% but does not affect the endocytic or exocytic rates of TfR cycling.	tet	71-83	homeostatic iron regulator	Homo sapiens	116-119
10092766-0	1999	Tetracycline up-regulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide.	tet	0-12	cytochrome c oxidase II, mitochondrial	Mus musculus	26-31
10218912-3	1999	To characterise the role of PS1 in apoptosis, we overexpressed the corresponding C-terminal fragment of PS1 (PS1-f) under the control of the tetracycline-responsive transactivator in Jurkat cells.	tet	141-153	presenilin 1	Homo sapiens	104-107
10218912-3	1999	To characterise the role of PS1 in apoptosis, we overexpressed the corresponding C-terminal fragment of PS1 (PS1-f) under the control of the tetracycline-responsive transactivator in Jurkat cells.	tet	141-153	presenilin 1	Homo sapiens	109-114
10195880-0	1999	In vivo manipulation of interleukin-2 expression by a retroviral tetracycline (tet)-regulated system.	tet	65-77	interleukin 2	Homo sapiens	24-37
10096574-3	1999	Transfectants grown in the presence of tetracycline contained about 15,000 receptors/cell, a value approximately equal to basal level GR expression in glucocorticoid-sensitive 6TG1.1 cells before steroid treatment.	tet	39-51	nuclear receptor subfamily 3 group C member 1	Homo sapiens	134-136
10070974-4	1999	MCF7 cells cultured without tetracycline resulted in a 6-fold increase in the cyclin D1 protein.	tet	28-40	cyclin D1	Homo sapiens	78-87
10195880-0	1999	In vivo manipulation of interleukin-2 expression by a retroviral tetracycline (tet)-regulated system.	tet	65-68	interleukin 2	Homo sapiens	24-37
10195880-6	1999	A fine tuning of IL-2 expression could be achieved by culturing the transduced cells with increasing doses of tet, whereby a concentration of 500 ng/mL tet in the culture medium abrogated IL-2 expression.	tet	110-113	interleukin 2	Homo sapiens	17-21
10195880-6	1999	A fine tuning of IL-2 expression could be achieved by culturing the transduced cells with increasing doses of tet, whereby a concentration of 500 ng/mL tet in the culture medium abrogated IL-2 expression.	tet	110-113	interleukin 2	Homo sapiens	188-192
10195880-6	1999	A fine tuning of IL-2 expression could be achieved by culturing the transduced cells with increasing doses of tet, whereby a concentration of 500 ng/mL tet in the culture medium abrogated IL-2 expression.	tet	152-155	interleukin 2	Homo sapiens	17-21
10195880-6	1999	A fine tuning of IL-2 expression could be achieved by culturing the transduced cells with increasing doses of tet, whereby a concentration of 500 ng/mL tet in the culture medium abrogated IL-2 expression.	tet	152-155	interleukin 2	Homo sapiens	188-192
10195880-9	1999	Instead, the inhibition of IL-2 expression in the transduced tumor cells by oral administration of tet led to subcutaneous tumor growth; this growth rate was comparable with the growth rate of subcutaneously inoculated untransduced parental cells.	tet	99-102	interleukin 2	Homo sapiens	27-31
10435080-3	1999	The potential for systemic use of these viruses in targeting metastases might be enhanced if NS1 expression and viral replication could be controlled by an innocuous drug such as tetracycline.	tet	179-191	influenza virus NS1A binding protein	Homo sapiens	93-96
10095792-7	1999	The observed mammary-specific and high expression of the doxycycline inducible reporter gene (up to 5.2 mg of recombinant alpha-lactalbumin.mL-1 of milk, i.e. up to 13-fold induction) opens up exciting prospects to use the tetracycline system to study the development and functioning of the mammary gland, and to control the production level of active pharmaceutical proteins in the milk of transgenic animals.	tet	223-235	lactalbumin, alpha	Mus musculus	122-139
10022894-2	1999	We examined the chaperone activity and cellular heat resistance of a clonal cell line in which overexpression of Hsp70 was transiently induced by means of the tetracycline-regulated gene expression system.	tet	159-171	heat shock protein family A (Hsp70) member 4	Homo sapiens	113-118
10224674-6	1999	Levels of endogenous progastrin-derived peptides were modified by stable transfection of NRK cells with tetracycline-repressible plasmids containing sequences encoding human gastrin in either the sense or antisense orientation.	tet	104-116	gastrin	Homo sapiens	24-31
10022894-7	1999	In order to study the contribution of the Hsp70 chaperone activity, heat resistance of cells that expressed tetracycline-regulated Hsp70 was compared to thermotolerant cells expressing the same level of Hsp70 plus all of the other heat shock proteins.	tet	108-120	heat shock protein family A (Hsp70) member 4	Homo sapiens	131-136
10022894-7	1999	In order to study the contribution of the Hsp70 chaperone activity, heat resistance of cells that expressed tetracycline-regulated Hsp70 was compared to thermotolerant cells expressing the same level of Hsp70 plus all of the other heat shock proteins.	tet	108-120	heat shock protein family A (Hsp70) member 4	Homo sapiens	131-136
10047468-4	1999	In this paper, we tested whether the endogenous ODC gene might be a target of WT1 by establishing lines of baby hamster kidney (BHK) cells that expressed WT1 isoform A under control of a tetracycline-regulated expression system.	tet	187-199	Wilms tumor protein	Mesocricetus auratus	78-81
10339711-3	1999	He became asymptomatic on treatment with tetracycline, rifampicin and streptomycin with significant CSF response.	tet	41-53	colony stimulating factor 2	Homo sapiens	100-103
10050884-2	1999	To investigate the effect of ectopic MycN expression on the susceptibility of neuroblastoma cells to cytotoxic drugs we used a human neuroblastoma cell line harboring tetracycline-controlled expression of MycN.	tet	167-179	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	37-41
10050884-2	1999	To investigate the effect of ectopic MycN expression on the susceptibility of neuroblastoma cells to cytotoxic drugs we used a human neuroblastoma cell line harboring tetracycline-controlled expression of MycN.	tet	167-179	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	205-209
9971741-4	1999	A reverse tetracycline-regulated inducible expression system was used to construct an AtT-20 corticotrope cell line capable of inducible PAM-1 expression.	tet	10-22	peptidylglycine alpha-amidating monooxygenase	Mus musculus	137-140
9891032-6	1999	In an effort to characterize the range of immunoregulatory genes controlled by IRF-3, we now demonstrate that endogenous human RANTES gene transcription is directly induced in tetracycline-inducible IRF-3(5D)-expressing cells or paramyxovirus-infected cells.	tet	176-188	interferon regulatory factor 3	Homo sapiens	79-84
10082214-4	1999	Upon tetracycline removal, electrophysiological recordings using the patch clamp technique indicated the expression of functional receptors with biophysical and pharmacological properties corresponding to those expected of the NR1a/NR2A subtype.	tet	5-17	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	232-236
11207718-5	1999	In contrast, the product of the transmissible TcR gene shares only 68% amino acid sequence identity with the TetO and TetM proteins and represents a new class of ribosome protection tetracycline resistance determinant, designated Tet W. The tet(W) coding region shows a higher DNA G + C content (53%) than other B. fibrisolvens genes or other ribosome protection-type tet genes, suggesting recent acquisition from a high G + C content genome.	tet	182-194	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	46-49
9891032-6	1999	In an effort to characterize the range of immunoregulatory genes controlled by IRF-3, we now demonstrate that endogenous human RANTES gene transcription is directly induced in tetracycline-inducible IRF-3(5D)-expressing cells or paramyxovirus-infected cells.	tet	176-188	C-C motif chemokine ligand 5	Homo sapiens	127-133
9891032-6	1999	In an effort to characterize the range of immunoregulatory genes controlled by IRF-3, we now demonstrate that endogenous human RANTES gene transcription is directly induced in tetracycline-inducible IRF-3(5D)-expressing cells or paramyxovirus-infected cells.	tet	176-188	interferon regulatory factor 3	Homo sapiens	199-204
9891091-7	1999	Treatment of RKO cells with a tetracycline derivative, doxycycline, resulted in 15-fold-induced expression of TS protein and nearly complete suppression of p53 protein expression.	tet	30-42	tumor protein p53	Homo sapiens	156-159
10203578-5	1999	An oligodendrocyte-specific myelin basic protein (MBP) gene promoter controls the reversed tet-inducible transactivator.	tet	91-94	myelin basic protein	Homo sapiens	28-48
10203578-5	1999	An oligodendrocyte-specific myelin basic protein (MBP) gene promoter controls the reversed tet-inducible transactivator.	tet	91-94	myelin basic protein	Homo sapiens	50-53
10367286-2	1999	We describe a cloning vector, designated pCTBtet, carrying a tetracycline resistance gene (TetR) between the leader peptide and mature CTB.	tet	61-73	tetracycline resistance repressor protein TetR	Escherichia coli	91-95
9927213-4	1999	This hybrid protein binds to p53 and can interact with a synthetic promoter containing tetracycline-operator sequences.	tet	87-99	tumor protein p53	Homo sapiens	29-32
10367286-3	1999	Removal of TetR to insert oligonucleotides encoding fusion epitopes allowed for screening of tetracycline-sensitive clones.	tet	93-105	tetracycline resistance repressor protein TetR	Escherichia coli	11-15
9916127-4	1999	In a xenografted glioma, the selective vulnerability of immature vessels to VEGF loss was demonstrated by downregulating VEGF transgene expression using a tetracycline-regulated expression system.	tet	155-167	vascular endothelial growth factor A	Homo sapiens	76-80
9873062-4	1999	In this study, we have introduced glucosylceramide synthase (GCS) into wild type MCF-7 breast cancer cells using a retroviral tetracycline-on expression system, and we developed a cell line, MCF-7/GCS.	tet	126-138	UDP-glucose ceramide glucosyltransferase	Homo sapiens	61-64
9890898-0	1999	Tetracycline-chelated Mg2+ ion initiates helix unwinding in Tet repressor induction.	tet	0-12	mucin 7, secreted	Homo sapiens	22-25
9890898-3	1999	If the tetracycline-Mg2+ complex [MgTc]+ enters two identical binding tunnels buried within the TetR homodimer, a conformational change takes place, and the induced [TetR/[MgTc]+]2 complex releases operator DNA.	tet	7-19	mucin 7, secreted	Homo sapiens	20-23
10654431-0	1999	Tetracycline-controlled expression of glycosylated porcine interferon-gamma in mammalian cells.	tet	0-12	interferon gamma	Homo sapiens	59-75
10654431-1	1999	Tetracycline-controlled expression plasmids that allow inducible expression of proteins in mammalian cells (Gossen & Bujard, 1992), have been used to express porcine interferon-gamma in the RK-13 rabbit kidney cell line.	tet	0-12	interferon gamma	Homo sapiens	170-186
9882678-4	1999	Subcloning, transposon mutagenesis, and DNA sequence analysis revealed that this DNA fragment contained two divergently transcribed genes, tetA and tetR, encoding products that were very similar to proteins of the Tet(A) class of tetracycline resistance systems.	tet	230-242	TetR family transcriptional regulator	Agrobacterium fabrum str. C58	148-152
16232563-1	1999	Corn starch and soybean oil are suitable carbon sources for the production of tetracycline by Streptomyces aureofacience CG-1.	tet	78-90	beta-conglycinin alpha' subunit	Glycine max	121-125
9916127-4	1999	In a xenografted glioma, the selective vulnerability of immature vessels to VEGF loss was demonstrated by downregulating VEGF transgene expression using a tetracycline-regulated expression system.	tet	155-167	vascular endothelial growth factor A	Homo sapiens	121-125
9864370-1	1998	In this report, we have analyzed the potential role and mechanisms of integrin signaling through FAK in cell cycle regulation by using tetracycline-regulated expression of exogenous FAK and mutants.	tet	135-147	protein tyrosine kinase 2	Homo sapiens	97-100
9813060-3	1998	Transforming growth factor alpha (TGF-alpha) was ectopically expressed by stable transfection of a TGF-alpha cDNA under repressible tetracycline control.	tet	132-144	tumor necrosis factor	Homo sapiens	0-32
9813060-3	1998	Transforming growth factor alpha (TGF-alpha) was ectopically expressed by stable transfection of a TGF-alpha cDNA under repressible tetracycline control.	tet	132-144	transforming growth factor alpha	Homo sapiens	34-43
9813060-9	1998	The administration of tetracycline reversed the effects of TGF-alpha expression in these cells both in vivo and in vitro, indicating that the alterations of the biological properties were due to the expression of TGF-alpha.	tet	22-34	transforming growth factor alpha	Homo sapiens	59-68
9813060-9	1998	The administration of tetracycline reversed the effects of TGF-alpha expression in these cells both in vivo and in vitro, indicating that the alterations of the biological properties were due to the expression of TGF-alpha.	tet	22-34	transforming growth factor alpha	Homo sapiens	213-222
9823311-3	1998	To further characterize the role of p73 in tumor suppression, we established several groups of cell lines that inducibly express p73 under a tetracycline-regulated promoter.	tet	141-153	tumor protein p73	Homo sapiens	129-132
9825805-4	1998	METHODS: Based on the tetracycline-regulated expression system, constructs were designed that allow endothelial cell-specific and regulated expression of FasL by placing the tetracycline-dependent transactivator under control of the murine intercellular adhesion molecule-2 promoter.	tet	22-34	Fas ligand (TNF superfamily, member 6)	Mus musculus	154-158
9825805-4	1998	METHODS: Based on the tetracycline-regulated expression system, constructs were designed that allow endothelial cell-specific and regulated expression of FasL by placing the tetracycline-dependent transactivator under control of the murine intercellular adhesion molecule-2 promoter.	tet	174-186	Fas ligand (TNF superfamily, member 6)	Mus musculus	154-158
9824154-4	1998	Here, we show, using a tetracycline-regulated system in p53-deficient DLD-1 human colon cancer cells, that p21 protein levels and stability are regulated by the proteasome-dependent degradation pathway and by association with its partners, CDKs and PCNA.	tet	23-35	cyclin dependent kinase inhibitor 1A	Homo sapiens	107-110
9824154-4	1998	Here, we show, using a tetracycline-regulated system in p53-deficient DLD-1 human colon cancer cells, that p21 protein levels and stability are regulated by the proteasome-dependent degradation pathway and by association with its partners, CDKs and PCNA.	tet	23-35	proliferating cell nuclear antigen	Homo sapiens	249-253
9972128-0	1998	Tetracycline-based MMP inhibitors can prevent fibroblast-mediated collagen gel contraction in vitro.	tet	0-12	matrix metallopeptidase 2	Homo sapiens	19-22
9772303-5	1998	Tetracycline-inducible antisense expression of HPV18 E6 in human cervical carcinoma HeLa cells resulted in increased level of p53 but did not affect expression of MN/CA IX protein.	tet	0-12	tumor protein p53	Homo sapiens	126-129
9839855-2	1998	The device is a monolithic ethylene vinyl-acetate fibre loaded with 25% w/w tetracycline HCI (tetracycline fibre).	tet	76-88	HEMC	Homo sapiens	89-92
10341450-2	1998	We have characterized and evaluated a tetracycline-responsive endothelial-specific binary system during mouse development, by engineering several transgenic lines which drive the expression of a tetracycline-controlled transactivator (tTA) under the control of either the Tek or Tie promoters (driver lines).	tet	38-50	TEK receptor tyrosine kinase	Mus musculus	272-275
9776410-3	1998	To investigate the putative tumor suppressor activity of RB2/p130 more directly, we utilized a tetracycline-regulated gene expression system to control expression of the encoded protein pRb2/p130 in JC virus-induced hamster brain tumor cells and to study the effects of pRb2/p130 on the growth of such tumor cells in nude mice.	tet	95-107	proline rich protein BstNI subfamily 2	Homo sapiens	186-190
9776410-3	1998	To investigate the putative tumor suppressor activity of RB2/p130 more directly, we utilized a tetracycline-regulated gene expression system to control expression of the encoded protein pRb2/p130 in JC virus-induced hamster brain tumor cells and to study the effects of pRb2/p130 on the growth of such tumor cells in nude mice.	tet	95-107	RB transcriptional corepressor like 2	Homo sapiens	191-195
9776410-3	1998	To investigate the putative tumor suppressor activity of RB2/p130 more directly, we utilized a tetracycline-regulated gene expression system to control expression of the encoded protein pRb2/p130 in JC virus-induced hamster brain tumor cells and to study the effects of pRb2/p130 on the growth of such tumor cells in nude mice.	tet	95-107	RB transcriptional corepressor like 2	Homo sapiens	191-195
9766676-7	1998	Moreover, analysis of a tetracycline-regulated p53-inducible system in null-p53 cell lines showed that RTP/rit42 mRNA expression increased concomitantly with p53 expression and followed a similar time course.	tet	24-36	tumor protein p53	Homo sapiens	47-50
9766676-7	1998	Moreover, analysis of a tetracycline-regulated p53-inducible system in null-p53 cell lines showed that RTP/rit42 mRNA expression increased concomitantly with p53 expression and followed a similar time course.	tet	24-36	tumor protein p53	Homo sapiens	76-79
9766676-7	1998	Moreover, analysis of a tetracycline-regulated p53-inducible system in null-p53 cell lines showed that RTP/rit42 mRNA expression increased concomitantly with p53 expression and followed a similar time course.	tet	24-36	N-myc downstream regulated 1	Homo sapiens	103-106
9766676-7	1998	Moreover, analysis of a tetracycline-regulated p53-inducible system in null-p53 cell lines showed that RTP/rit42 mRNA expression increased concomitantly with p53 expression and followed a similar time course.	tet	24-36	N-myc downstream regulated 1	Homo sapiens	107-112
9766676-7	1998	Moreover, analysis of a tetracycline-regulated p53-inducible system in null-p53 cell lines showed that RTP/rit42 mRNA expression increased concomitantly with p53 expression and followed a similar time course.	tet	24-36	tumor protein p53	Homo sapiens	76-79
9934678-1	1999	A tetracycline-inducible expression system has been established for the prion protein (PrP) in murine neuroblastoma cells (N2a).	tet	2-14	prion protein	Mus musculus	87-90
9934678-6	1999	Furthermore, the selected N2a clones allowed the Prnp expression level to be quantitatively controlled by varying the level of the effector substance, the tetracycline-derivative doxycycline.	tet	155-167	prion protein	Mus musculus	49-53
9857069-9	1998	Using a modified tetracycline-regulated PP2Cdelta-GFP dicistronic expression cassette, it was revealed that overexpression of PP2Cdelta blocked cell cycle progression and arrested cells at early S phase, resulting in inhibition of DNA synthesis and leading to cell death.	tet	17-29	ILK associated serine/threonine phosphatase	Homo sapiens	40-49
9857069-9	1998	Using a modified tetracycline-regulated PP2Cdelta-GFP dicistronic expression cassette, it was revealed that overexpression of PP2Cdelta blocked cell cycle progression and arrested cells at early S phase, resulting in inhibition of DNA synthesis and leading to cell death.	tet	17-29	ILK associated serine/threonine phosphatase	Homo sapiens	126-135
9861448-0	1998	Interactions of photosensitized tetracycline with serum albumin.	tet	32-44	albumin	Homo sapiens	50-63
9861448-1	1998	Interactions of tetracycline with bovine serum albumin (BSA) were studied by fluorescence quenching and circular dichroism (CD) analysis.	tet	16-28	albumin	Homo sapiens	41-54
9843495-2	1998	To investigate further the mechanisms of PKR-induced growth inhibition, we have developed tetracycline-inducible murine cell lines that express wild-type PKR or a catalytically inactive PKR variant, PKRdelta6.	tet	90-102	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	41-44
9843495-2	1998	To investigate further the mechanisms of PKR-induced growth inhibition, we have developed tetracycline-inducible murine cell lines that express wild-type PKR or a catalytically inactive PKR variant, PKRdelta6.	tet	90-102	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	154-157
9843495-2	1998	To investigate further the mechanisms of PKR-induced growth inhibition, we have developed tetracycline-inducible murine cell lines that express wild-type PKR or a catalytically inactive PKR variant, PKRdelta6.	tet	90-102	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	154-157
10023442-9	1998	We also provided wild-type p53 and p53 delta 326 with tetracycline-regulated promoters and stably introduced these constructs into Saos2 and SKBR3 cells.	tet	54-66	tumor protein p53	Homo sapiens	35-38
9828211-5	1998	We used a self-contained, tetracycline-regulated retroviral vector system to elucidate the effect of VEGF on murine HCC development in a xenograft experimental model.	tet	26-38	vascular endothelial growth factor A	Mus musculus	101-105
9828211-6	1998	By delivering the VEGF gene within the retroviral vector and under the control of a tetracycline-regulated promoter, we were able to manipulate VEGF expression in vivo tumor by providing tetracycline in the drinking water.	tet	84-96	vascular endothelial growth factor A	Mus musculus	144-148
9828211-6	1998	By delivering the VEGF gene within the retroviral vector and under the control of a tetracycline-regulated promoter, we were able to manipulate VEGF expression in vivo tumor by providing tetracycline in the drinking water.	tet	187-199	vascular endothelial growth factor A	Mus musculus	18-22
9828211-6	1998	By delivering the VEGF gene within the retroviral vector and under the control of a tetracycline-regulated promoter, we were able to manipulate VEGF expression in vivo tumor by providing tetracycline in the drinking water.	tet	187-199	vascular endothelial growth factor A	Mus musculus	144-148
9845660-13	1998	Tetracycline derivatives limited the disruption of medial elastin without appearing to alter either the inflammatory response or the rat aortic wall production of metallogelatinases.	tet	0-12	elastin	Rattus norvegicus	58-65
9843215-0	1998	Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16.	tet	0-12	cyclin dependent kinase inhibitor 2A	Homo sapiens	106-109
9864370-1	1998	In this report, we have analyzed the potential role and mechanisms of integrin signaling through FAK in cell cycle regulation by using tetracycline-regulated expression of exogenous FAK and mutants.	tet	135-147	protein tyrosine kinase 2	Homo sapiens	182-185
9748432-1	1998	The Candida glabrata KRE9 (CgKRE9) and KNH1 (CgKNH1) genes have been isolated as multicopy suppressors of the tetracycline-sensitive growth of a Saccharomyces cerevisiae mutant with the disrupted KNH1 locus and the KRE9 gene placed under the control of a tetracycline-responsive promoter.	tet	110-122	Kre9p	Saccharomyces cerevisiae S288C	21-25
9748432-1	1998	The Candida glabrata KRE9 (CgKRE9) and KNH1 (CgKNH1) genes have been isolated as multicopy suppressors of the tetracycline-sensitive growth of a Saccharomyces cerevisiae mutant with the disrupted KNH1 locus and the KRE9 gene placed under the control of a tetracycline-responsive promoter.	tet	110-122	Knh1p	Saccharomyces cerevisiae S288C	39-43
9748432-1	1998	The Candida glabrata KRE9 (CgKRE9) and KNH1 (CgKNH1) genes have been isolated as multicopy suppressors of the tetracycline-sensitive growth of a Saccharomyces cerevisiae mutant with the disrupted KNH1 locus and the KRE9 gene placed under the control of a tetracycline-responsive promoter.	tet	110-122	Knh1p	Saccharomyces cerevisiae S288C	47-51
9748432-1	1998	The Candida glabrata KRE9 (CgKRE9) and KNH1 (CgKNH1) genes have been isolated as multicopy suppressors of the tetracycline-sensitive growth of a Saccharomyces cerevisiae mutant with the disrupted KNH1 locus and the KRE9 gene placed under the control of a tetracycline-responsive promoter.	tet	110-122	Kre9p	Saccharomyces cerevisiae S288C	29-33
9742093-3	1998	Using a tetracycline-regulatable expression system, overexpression of Fer in embryonic fibroblasts was shown to evoke a massive rounding up, and the subsequent detachment of the cells from the substratum, which eventually led to cell death.	tet	8-20	FER tyrosine kinase	Homo sapiens	70-73
9748432-1	1998	The Candida glabrata KRE9 (CgKRE9) and KNH1 (CgKNH1) genes have been isolated as multicopy suppressors of the tetracycline-sensitive growth of a Saccharomyces cerevisiae mutant with the disrupted KNH1 locus and the KRE9 gene placed under the control of a tetracycline-responsive promoter.	tet	255-267	Kre9p	Saccharomyces cerevisiae S288C	21-25
9748432-1	1998	The Candida glabrata KRE9 (CgKRE9) and KNH1 (CgKNH1) genes have been isolated as multicopy suppressors of the tetracycline-sensitive growth of a Saccharomyces cerevisiae mutant with the disrupted KNH1 locus and the KRE9 gene placed under the control of a tetracycline-responsive promoter.	tet	255-267	Knh1p	Saccharomyces cerevisiae S288C	39-43
9748432-1	1998	The Candida glabrata KRE9 (CgKRE9) and KNH1 (CgKNH1) genes have been isolated as multicopy suppressors of the tetracycline-sensitive growth of a Saccharomyces cerevisiae mutant with the disrupted KNH1 locus and the KRE9 gene placed under the control of a tetracycline-responsive promoter.	tet	255-267	Knh1p	Saccharomyces cerevisiae S288C	47-51
9748432-1	1998	The Candida glabrata KRE9 (CgKRE9) and KNH1 (CgKNH1) genes have been isolated as multicopy suppressors of the tetracycline-sensitive growth of a Saccharomyces cerevisiae mutant with the disrupted KNH1 locus and the KRE9 gene placed under the control of a tetracycline-responsive promoter.	tet	255-267	Kre9p	Saccharomyces cerevisiae S288C	29-33
9794230-8	1998	Finally, using a chimeric EVI-1-VP16-fusion protein under the control of a tetracycline-regulated system, we have shown that this chimeric activator can directly regulate Itpr2.	tet	75-87	MDS1 and EVI1 complex locus	Mus musculus	26-31
11245004-0	1998	[A study on the tumor suppressing effect of a specific point mutant p53 minigene in the expression regulated model with a tetracycline-transactivative response promoter].	tet	122-134	tumor protein p53	Homo sapiens	68-71
11245004-1	1998	OBJECTIVE: To establish a tetracycline-regulated expression model and to determine and verify whether a specific point mutant type p53 minigene, containing an Arg-->Leu substitution at amino acid 172, possesses a suppressing effect on human lung cancer.	tet	26-38	tumor protein p53	Homo sapiens	131-134
11245004-3	1998	Then the specific p53 minigene was sub-cloned into a tetracycline-transactivative controlled expression vector pBPSTR1 by gene recombination methods.	tet	53-65	tumor protein p53	Homo sapiens	18-21
11245004-6	1998	The tetracycline transactivative p53 minigene-regulated transgene model was successfully established.	tet	4-16	tumor protein p53	Homo sapiens	33-36
9794226-3	1998	To address these issues, we have generated rodent fibroblast cell lines that harbor a human c-myc gene under the control of a tetracycline-regulated promoter.	tet	126-138	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	92-97
9794230-8	1998	Finally, using a chimeric EVI-1-VP16-fusion protein under the control of a tetracycline-regulated system, we have shown that this chimeric activator can directly regulate Itpr2.	tet	75-87	inositol 1,4,5-triphosphate receptor 2	Mus musculus	171-176
9730962-2	1998	To ask directly if the PKCalpha isoform mediates this suppression, we have developed Y-1 cell lines in which PKCalpha is expressed from a tetracycline-regulated promoter.	tet	138-150	protein kinase C alpha	Homo sapiens	109-117
9743352-4	1998	To directly examine the effects of BSAP on isotype switching, we use a tetracycline-regulated expression system to overexpress BSAP in the surface IgM+ I.29 mu B cell line, a mouse cell line that can be induced to undergo class switch recombination.	tet	71-83	paired box 5	Mus musculus	127-131
9733464-10	1998	All 6 CMT had identical C1-3 and C10-12a positions in the 4-ringed nucleus of the tetracycline molecule.	tet	82-94	homeobox C13	Homo sapiens	24-28
9744804-2	1998	We have previously identified a transcript at 11p15.5 which encodes a putative membrane transport protein, designated organic cation transporter-like 2 (ORCTL2), that shares homology with tetracycline resistance proteins and bacterial multidrug resistance proteins.	tet	188-200	solute carrier family 22 member 18	Homo sapiens	118-151
9730908-4	1998	We report here the generation, using a modified tetracycline-regulated system under the control of the neuron-specific enolase promoter, of several lines of mice that direct transgene expression to specific brain regions, including the striatum, cerebellum, CA1 region of the hippocampus, or deep layers of cerebral neocortex.	tet	48-60	carbonic anhydrase 1	Mus musculus	258-261
9789363-10	1998	MRSA-strains were more resistant to imipenem, ofloxacin, gentamicin, trimethoprim-sulfamethoxazole, tetracycline, erythromycin and clindamycin as oxacillin-sensitive Straphylococcus aureus strains.	tet	100-112	solute carrier family 9 member A6	Homo sapiens	0-4
9705350-16	1998	In this study, HeLa cells were transfected with HFE under the control of the tetracycline-repressible promoter.	tet	77-89	homeostatic iron regulator	Homo sapiens	48-51
9744804-2	1998	We have previously identified a transcript at 11p15.5 which encodes a putative membrane transport protein, designated organic cation transporter-like 2 (ORCTL2), that shares homology with tetracycline resistance proteins and bacterial multidrug resistance proteins.	tet	188-200	solute carrier family 22 member 18	Homo sapiens	153-159
9716424-2	1998	cDNAs were connected downstream of the TcIP promoter and stably transfected into interleukin (IL-2 or IL-3)-dependent lymphoid cells that ectopically coexpress the tetracycline-repressible transactivator and the lac repressor.	tet	164-176	interleukin 2	Homo sapiens	94-98
9688609-1	1998	The Ca2+-independent delta-isoform of protein kinase C (PKC-delta) was overexpressed in LLC-PK1 epithelia and placed under control of a tetracycline-responsive expression system.	tet	136-148	PRKCD	Sus scrofa	56-65
9688609-2	1998	In the absence of tetracycline, the exogenous PKC-delta is expressed.	tet	18-30	PRKCD	Sus scrofa	46-55
9688609-5	1998	Transepithelial electrical resistance (RT) in cell sheets overexpressing PKC-delta was only 20% of that in cell sheets incubated in the presence of tetracycline, in which the amount of PKC-delta and RT were similar to those in LLC-PK1 parental cell sheets.	tet	148-160	PRKCD	Sus scrofa	185-194
9716424-2	1998	cDNAs were connected downstream of the TcIP promoter and stably transfected into interleukin (IL-2 or IL-3)-dependent lymphoid cells that ectopically coexpress the tetracycline-repressible transactivator and the lac repressor.	tet	164-176	interleukin 3	Homo sapiens	102-106
9679138-3	1998	If expressed in HeLa cells in a tetracycline-inducible manner, this mutant accumulated in the ER and retained the endogenous ERGIC-53 in this compartment, thus preventing its recycling.	tet	32-44	lectin, mannose binding 1	Homo sapiens	125-133
9661919-5	1998	We found that these cells are positive for Ki-67 even when they are arrested in G1/S or G2/M by using synchronizing inhibitors, by inducing p21(Waf1/Cip1) in a tetracycline-regulated expression system or by inducing wild type p53 and p21 after inflicting DNA damage.	tet	160-172	cyclin dependent kinase inhibitor 1A	Homo sapiens	140-143
9690515-4	1998	Using human neuroblastoma cells harbouring tetracycline controlled expression of MYCN we have analysed the role of the MycN protein and IFNgamma in cell death decision.	tet	43-55	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	81-85
9692552-6	1998	RIE-1 cells were engineered to overexpress human cyclin D1 under the control of a tetracycline-repressible promoter.	tet	82-94	cyclin D1	Homo sapiens	49-58
9692552-7	1998	These cells entered S phase in the presence of TGF-beta1 only when human cyclin D1 was derepressed by the withdrawal of tetracycline.	tet	120-132	cyclin D1	Homo sapiens	73-82
9661919-5	1998	We found that these cells are positive for Ki-67 even when they are arrested in G1/S or G2/M by using synchronizing inhibitors, by inducing p21(Waf1/Cip1) in a tetracycline-regulated expression system or by inducing wild type p53 and p21 after inflicting DNA damage.	tet	160-172	cyclin dependent kinase inhibitor 1A	Homo sapiens	144-148
9573031-2	1998	We generated a hematopoietic cell line, TonB210.1, with tetracycline-dependent BCR/ABL expression to investigate the pathways by which BCR/ABL transforms cells.	tet	56-68	BCR activator of RhoGEF and GTPase	Mus musculus	79-86
9661919-5	1998	We found that these cells are positive for Ki-67 even when they are arrested in G1/S or G2/M by using synchronizing inhibitors, by inducing p21(Waf1/Cip1) in a tetracycline-regulated expression system or by inducing wild type p53 and p21 after inflicting DNA damage.	tet	160-172	cyclin dependent kinase inhibitor 1A	Homo sapiens	149-153
9661919-5	1998	We found that these cells are positive for Ki-67 even when they are arrested in G1/S or G2/M by using synchronizing inhibitors, by inducing p21(Waf1/Cip1) in a tetracycline-regulated expression system or by inducing wild type p53 and p21 after inflicting DNA damage.	tet	160-172	tumor protein p53	Homo sapiens	226-229
9661919-5	1998	We found that these cells are positive for Ki-67 even when they are arrested in G1/S or G2/M by using synchronizing inhibitors, by inducing p21(Waf1/Cip1) in a tetracycline-regulated expression system or by inducing wild type p53 and p21 after inflicting DNA damage.	tet	160-172	cyclin dependent kinase inhibitor 1A	Homo sapiens	234-237
9647762-3	1998	Using a subtractive hybridization approach in combination with tetracycline operator systems, we identified a set of downstream genes affected by Tsc2.	tet	63-75	TSC complex subunit 2	Rattus norvegicus	146-150
9618196-3	1998	In pooled transfectants of CHO, tetracycline induced the expression of beta-galactosidase in 10-30% of cells.	tet	32-44	beta-galactosidase	Cricetulus griseus	71-89
9618196-4	1998	Using clonal transfectants, beta-galactosidase expression was induced by tetracycline in essentially every cell.	tet	73-85	beta-galactosidase	Cricetulus griseus	28-46
9618196-5	1998	Furthermore, induction of beta-galactosidase expression by tetracycline was both dose- and time-dependent.	tet	59-71	beta-galactosidase	Cricetulus griseus	26-44
9618196-6	1998	Similar tetracycline-induced beta-galactosidase expression is also observed in other cell types.	tet	8-20	beta-galactosidase	Cricetulus griseus	29-47
9584119-3	1998	We found that expression of beta-galactosidase can be efficiently inhibited in embryos and larvae with tetracycline provided in the food, and that a simple removal of the larvae from tetracycline exposure results in the induction of the enzyme in a time- and concentration-dependent manner.	tet	103-115	beta galactosidase	Drosophila melanogaster	28-46
9584119-3	1998	We found that expression of beta-galactosidase can be efficiently inhibited in embryos and larvae with tetracycline provided in the food, and that a simple removal of the larvae from tetracycline exposure results in the induction of the enzyme in a time- and concentration-dependent manner.	tet	183-195	beta galactosidase	Drosophila melanogaster	28-46
9573031-2	1998	We generated a hematopoietic cell line, TonB210.1, with tetracycline-dependent BCR/ABL expression to investigate the pathways by which BCR/ABL transforms cells.	tet	56-68	BCR activator of RhoGEF and GTPase	Mus musculus	79-82
9573031-2	1998	We generated a hematopoietic cell line, TonB210.1, with tetracycline-dependent BCR/ABL expression to investigate the pathways by which BCR/ABL transforms cells.	tet	56-68	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	83-86
9575175-6	1998	Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline-regulated transactivator and operator plasmids to control the expression of wild-type p53 (TR9-7 cells), we then show that the induction of p21(WAF1/Cip1), which occurs in response to the inhibition of PP5 expression, requires the p53 protein.	tet	87-99	tumor protein p53	Homo sapiens	186-189
9771972-5	1998	To identify endogenous WT1 target genes we established HEK293 cell lines expressing the different WT1 isoforms in a tetracycline dependent manner.	tet	116-128	WT1 transcription factor	Homo sapiens	23-26
9575175-6	1998	Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline-regulated transactivator and operator plasmids to control the expression of wild-type p53 (TR9-7 cells), we then show that the induction of p21(WAF1/Cip1), which occurs in response to the inhibition of PP5 expression, requires the p53 protein.	tet	87-99	cyclin dependent kinase inhibitor 1A	Homo sapiens	240-243
9771972-5	1998	To identify endogenous WT1 target genes we established HEK293 cell lines expressing the different WT1 isoforms in a tetracycline dependent manner.	tet	116-128	WT1 transcription factor	Homo sapiens	98-101
9575175-6	1998	Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline-regulated transactivator and operator plasmids to control the expression of wild-type p53 (TR9-7 cells), we then show that the induction of p21(WAF1/Cip1), which occurs in response to the inhibition of PP5 expression, requires the p53 protein.	tet	87-99	cyclin dependent kinase inhibitor 1A	Homo sapiens	244-248
9575175-6	1998	Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline-regulated transactivator and operator plasmids to control the expression of wild-type p53 (TR9-7 cells), we then show that the induction of p21(WAF1/Cip1), which occurs in response to the inhibition of PP5 expression, requires the p53 protein.	tet	87-99	cyclin dependent kinase inhibitor 1A	Homo sapiens	249-253
9575175-6	1998	Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline-regulated transactivator and operator plasmids to control the expression of wild-type p53 (TR9-7 cells), we then show that the induction of p21(WAF1/Cip1), which occurs in response to the inhibition of PP5 expression, requires the p53 protein.	tet	87-99	protein phosphatase 5 catalytic subunit	Homo sapiens	302-305
9575175-6	1998	Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline-regulated transactivator and operator plasmids to control the expression of wild-type p53 (TR9-7 cells), we then show that the induction of p21(WAF1/Cip1), which occurs in response to the inhibition of PP5 expression, requires the p53 protein.	tet	87-99	tumor protein p53	Homo sapiens	186-189
9607411-3	1998	To control the expression of these hormones in the present study, a promoter that is inducible by administration of tetracycline derivatives such as doxycycline (Dox) was linked to the POMC gene.	tet	116-128	pro-opiomelanocortin-alpha	Mus musculus	185-189
9575227-1	1998	The tetracycline-responsive expression system of Bujard was used to compare rates of decay of wild-type and mutant neurofilament (NF) light subunit (NF-L) mRNAs.	tet	4-16	neurofilament, light polypeptide	Mus musculus	149-153
9589383-5	1998	Using the tetracycline-regulated transactivator system, which allows controlled gene expression, we show that overexpression of p55-IC induces apoptosis in both naive and neuronal PC12 cells.	tet	10-22	TNF receptor superfamily member 1A	Rattus norvegicus	128-131
9572938-2	1998	A typical pACYC184-based plasmid which was obtained could express the major DnaK-DnaJ-GrpE and GroEL-GroES chaperone teams from separate promoters when L-arabinose and tetracycline, respectively, were added in a dose-dependent fashion.	tet	168-180	GroEL	Escherichia coli	95-100
9572938-2	1998	A typical pACYC184-based plasmid which was obtained could express the major DnaK-DnaJ-GrpE and GroEL-GroES chaperone teams from separate promoters when L-arabinose and tetracycline, respectively, were added in a dose-dependent fashion.	tet	168-180	chaperonin GroES	Escherichia coli	101-106
9593300-2	1998	The key components of this regulatory system are two contiguous transposon-borne genes, orf7 and orf8, located downstream from and having the same polarity of transcription as the tetracycline resistance determinant tetM.	tet	180-192	hypothetical protein	Bacillus subtilis	97-101
9490641-8	1998	Inhibition of p53 function in the cells with tetracycline-regulated p53 gene expression, as well as in the cells expressing ts-p53 or p53-GSE, abolished cell cycle arrest in micronucleated cells.	tet	45-57	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	14-17
9490641-8	1998	Inhibition of p53 function in the cells with tetracycline-regulated p53 gene expression, as well as in the cells expressing ts-p53 or p53-GSE, abolished cell cycle arrest in micronucleated cells.	tet	45-57	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	68-71
9490641-8	1998	Inhibition of p53 function in the cells with tetracycline-regulated p53 gene expression, as well as in the cells expressing ts-p53 or p53-GSE, abolished cell cycle arrest in micronucleated cells.	tet	45-57	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	68-71
9490641-8	1998	Inhibition of p53 function in the cells with tetracycline-regulated p53 gene expression, as well as in the cells expressing ts-p53 or p53-GSE, abolished cell cycle arrest in micronucleated cells.	tet	45-57	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	68-71
9593300-4	1998	In the presence of tetracycline, an attenuation mechanism enables the transcription of orf7 and orf8 from the tetM promoter.	tet	19-31	hypothetical protein	Bacillus subtilis	96-100
9492043-3	1998	The p53-induced regulation of IGF-IR levels was studied in a tetracycline-regulated expression system.	tet	61-73	insulin like growth factor 1 receptor	Homo sapiens	30-36
9516441-3	1998	In the present study, we examined the effect of tetracycline-inducible expression of transdominant repressors of IkappaBalpha (TD-IkappaBalpha) on HIV-1 multiplication using stably selected Jurkat T cells.	tet	48-60	NFKB inhibitor alpha	Homo sapiens	113-125
9516441-3	1998	In the present study, we examined the effect of tetracycline-inducible expression of transdominant repressors of IkappaBalpha (TD-IkappaBalpha) on HIV-1 multiplication using stably selected Jurkat T cells.	tet	48-60	NFKB inhibitor alpha	Homo sapiens	130-142
9492043-3	1998	The p53-induced regulation of IGF-IR levels was studied in a tetracycline-regulated expression system.	tet	61-73	tumor protein p53	Homo sapiens	4-7
9531057-0	1998	Tissue factor pathway inhibitor in tetracycline-induced pleuritis in rabbits.	tet	35-47	tissue factor pathway inhibitor	Oryctolagus cuniculus	0-31
9531057-2	1998	In this study, we sought to determine if tissue factor pathway inhibitor (TFPI), an inhibitor of the TF-factor VIIa complex, was likewise expressed in tetracycline (TCN)-induced pleural injury and, if so, whether TFPI was locally elaborated.	tet	151-163	tissue factor pathway inhibitor	Oryctolagus cuniculus	41-72
9531057-2	1998	In this study, we sought to determine if tissue factor pathway inhibitor (TFPI), an inhibitor of the TF-factor VIIa complex, was likewise expressed in tetracycline (TCN)-induced pleural injury and, if so, whether TFPI was locally elaborated.	tet	151-163	tissue factor pathway inhibitor	Oryctolagus cuniculus	74-78
9531057-2	1998	In this study, we sought to determine if tissue factor pathway inhibitor (TFPI), an inhibitor of the TF-factor VIIa complex, was likewise expressed in tetracycline (TCN)-induced pleural injury and, if so, whether TFPI was locally elaborated.	tet	165-168	tissue factor pathway inhibitor	Oryctolagus cuniculus	41-72
9531057-2	1998	In this study, we sought to determine if tissue factor pathway inhibitor (TFPI), an inhibitor of the TF-factor VIIa complex, was likewise expressed in tetracycline (TCN)-induced pleural injury and, if so, whether TFPI was locally elaborated.	tet	165-168	tissue factor pathway inhibitor	Oryctolagus cuniculus	74-78
9531057-3	1998	Pleural fluid TFPI activity approximated that of plasma by 24 h and doubled by 3 days after intrapleural TCN.	tet	105-108	tissue factor pathway inhibitor	Oryctolagus cuniculus	14-18
9531057-7	1998	TFPI is locally expressed and pleural fluid TFPI exceeds plasma levels during TCN-induced pleural injury.	tet	78-81	tissue factor pathway inhibitor	Oryctolagus cuniculus	0-4
9531057-7	1998	TFPI is locally expressed and pleural fluid TFPI exceeds plasma levels during TCN-induced pleural injury.	tet	78-81	tissue factor pathway inhibitor	Oryctolagus cuniculus	44-48
9531057-9	1998	TFPI expression temporally and anatomically approximates that of TF and may limit TF-induced fibrin deposition in evolving TCN-induced pleuritis.	tet	123-126	tissue factor pathway inhibitor	Oryctolagus cuniculus	0-4
9531057-9	1998	TFPI expression temporally and anatomically approximates that of TF and may limit TF-induced fibrin deposition in evolving TCN-induced pleuritis.	tet	123-126	tissue factor	Oryctolagus cuniculus	0-2
9467956-3	1998	Here, we show, using a tetracycline-regulated system, that expression of wild-type p21 in p53-deficient DLD1 human colon cancer cells inhibits DNA synthesis and causes G1 and G2 cell cycle arrest.	tet	23-35	cyclin dependent kinase inhibitor 1A	Homo sapiens	83-86
9467956-3	1998	Here, we show, using a tetracycline-regulated system, that expression of wild-type p21 in p53-deficient DLD1 human colon cancer cells inhibits DNA synthesis and causes G1 and G2 cell cycle arrest.	tet	23-35	tumor protein p53	Homo sapiens	90-93
9467962-4	1998	The maximum induced p21 levels in the absence of Tet were estimated to be ten times that of endogenous hamster p21.	tet	49-52	cyclin dependent kinase inhibitor 1A	Homo sapiens	20-23
9467962-5	1998	As p21 levels rose following removal of Tet, p21-associated histone H1 kinase activity was increased and concomitantly cell growth and DNA synthesis were reduced.	tet	40-43	cyclin dependent kinase inhibitor 1A	Homo sapiens	3-6
9467962-5	1998	As p21 levels rose following removal of Tet, p21-associated histone H1 kinase activity was increased and concomitantly cell growth and DNA synthesis were reduced.	tet	40-43	cyclin dependent kinase inhibitor 1A	Homo sapiens	45-48
9467962-6	1998	Tet-p21 BHK21 cells became arrested in G1 phase and lost colony forming ability irreversibly 2-4 days after removal of Tet.	tet	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	4-7
9467962-6	1998	Tet-p21 BHK21 cells became arrested in G1 phase and lost colony forming ability irreversibly 2-4 days after removal of Tet.	tet	119-122	cyclin dependent kinase inhibitor 1A	Homo sapiens	4-7
9467962-7	1998	The induction of cyclin E- and cyclin A-associated kinase activities was diminished when G0-synchronized Tet-p21 BHK21 cells were serum stimulated in the absence of Tet.	tet	105-108	cyclin dependent kinase inhibitor 1A	Homo sapiens	109-112
9464539-7	1998	We have established a NIH3T3 based cell line expressing the c-Raf-1-C4B protein under the control of a tetracycline responsive promoter (N-C4B-tet).	tet	103-115	v-raf-leukemia viral oncogene 1	Mus musculus	60-65
9575160-3	1998	To examine these possibilities, the human apoE gene was expressed in murine Y1 adrenocortical cells under control of an inducible tetracycline-regulated promoter.	tet	130-142	apolipoprotein E	Homo sapiens	42-46
9580095-0	1998	Construction and characterization of a stably transformed HeLa cell line in which the expression of bovine herpesvirus 1 ICP0 (BICP0) is induced by tetracycline.	tet	148-160	ubiquitin E3 ligase ICP0	Bovine alphaherpesvirus 1	100-125
9459485-6	1998	To address this issue, we developed stable transfectants of the HEK293 human fetal kidney epithelial cell line expressing human PAX2 protein under tetracycline-regulatable promoter.	tet	147-159	paired box 2	Homo sapiens	128-132
9580095-0	1998	Construction and characterization of a stably transformed HeLa cell line in which the expression of bovine herpesvirus 1 ICP0 (BICP0) is induced by tetracycline.	tet	148-160	ubiquitin E3 ligase ICP0	Bovine alphaherpesvirus 1	127-132
9580095-1	1998	To explore the effects BICP0 (a principal transactivator of BHV-1 gene expression) on viral promoter elements, we established a cell line in which the expression of BICP0 is regulated by tetracycline.	tet	187-199	ubiquitin E3 ligase ICP0	Bovine alphaherpesvirus 1	165-170
9580095-4	1998	Immunofluorescent assays indicated that BICP0 was synthesised in the transformed cell lines solely upon induction of the gene by tetracycline removal.	tet	129-141	ubiquitin E3 ligase ICP0	Bovine alphaherpesvirus 1	40-45
9580095-5	1998	Only cells which had been kept constantly in medium containing tetracycline were able to synthesise BICP0 upon induction.	tet	63-75	ubiquitin E3 ligase ICP0	Bovine alphaherpesvirus 1	100-105
9437511-1	1998	There are at least nine tetracycline (TC) analogs (both antimicrobial and nonantimicrobial) with documented capacity to inhibit, both in vitro and in vivo, the connective tissue degrading activity of matrix metalloproteinases (MMPs).	tet	24-36	matrix metallopeptidase 1	Homo sapiens	227-231
9437511-1	1998	There are at least nine tetracycline (TC) analogs (both antimicrobial and nonantimicrobial) with documented capacity to inhibit, both in vitro and in vivo, the connective tissue degrading activity of matrix metalloproteinases (MMPs).	tet	38-40	matrix metallopeptidase 1	Homo sapiens	227-231
9437511-6	1998	By carefully selecting a TC-based MMP inhibitor and controlling dosages, it should be possible to inhibit pathologically excessive MMP-8 and/or MMP-13 activity, especially that causing bone erosion, without affecting the constitutive levels of MMP-1 needed for tissue remodeling and normal host function; in this regard, three newly developed CMTs (especially CMT-8, and, to a lesser extent, CMT-3 and -7) appear to be most effective.	tet	25-27	matrix metallopeptidase 8	Homo sapiens	131-136
9437511-2	1998	Of the three MMPs that can degrade native helical collagens, MMP-13 (initially identified as rat osteoblast and human breast cancer collagenase, and now known to also be expressed by human cartilage and bone cells) is the most sensitive to TC inhibition (IC50 values in vitro generally less than 1 microgram/mL); the TCs inhibit both the collagenolytic as well as the gelatinolytic activity of this enzyme.	tet	240-242	matrix metallopeptidase 1	Homo sapiens	13-17
9437511-6	1998	By carefully selecting a TC-based MMP inhibitor and controlling dosages, it should be possible to inhibit pathologically excessive MMP-8 and/or MMP-13 activity, especially that causing bone erosion, without affecting the constitutive levels of MMP-1 needed for tissue remodeling and normal host function; in this regard, three newly developed CMTs (especially CMT-8, and, to a lesser extent, CMT-3 and -7) appear to be most effective.	tet	25-27	matrix metallopeptidase 13	Homo sapiens	144-150
9437511-6	1998	By carefully selecting a TC-based MMP inhibitor and controlling dosages, it should be possible to inhibit pathologically excessive MMP-8 and/or MMP-13 activity, especially that causing bone erosion, without affecting the constitutive levels of MMP-1 needed for tissue remodeling and normal host function; in this regard, three newly developed CMTs (especially CMT-8, and, to a lesser extent, CMT-3 and -7) appear to be most effective.	tet	25-27	matrix metallopeptidase 1	Homo sapiens	144-149
9437511-2	1998	Of the three MMPs that can degrade native helical collagens, MMP-13 (initially identified as rat osteoblast and human breast cancer collagenase, and now known to also be expressed by human cartilage and bone cells) is the most sensitive to TC inhibition (IC50 values in vitro generally less than 1 microgram/mL); the TCs inhibit both the collagenolytic as well as the gelatinolytic activity of this enzyme.	tet	240-242	matrix metallopeptidase 13	Rattus norvegicus	61-67
9437511-3	1998	The IC50 for MMP-8 (neutrophil collagenase) in vitro ranges from 15 to 86 micrograms/mL depending on assay conditions and choice of TC, whereas inhibition of the fibroblast enzyme (MMP-1) generally requires levels in excess of 200 micrograms/mL (except for CMT-3).	tet	132-134	matrix metallopeptidase 8	Homo sapiens	13-18
9437511-3	1998	The IC50 for MMP-8 (neutrophil collagenase) in vitro ranges from 15 to 86 micrograms/mL depending on assay conditions and choice of TC, whereas inhibition of the fibroblast enzyme (MMP-1) generally requires levels in excess of 200 micrograms/mL (except for CMT-3).	tet	132-134	matrix metallopeptidase 8	Homo sapiens	20-42
9437511-4	1998	The TC compounds that are highly effective against MMP-13 in vitro are also highly inhibitory of glycosaminoglycan release from interleukin-1-stimulated cartilage explants in culture.	tet	4-6	matrix metallopeptidase 13	Homo sapiens	51-57
9437511-4	1998	The TC compounds that are highly effective against MMP-13 in vitro are also highly inhibitory of glycosaminoglycan release from interleukin-1-stimulated cartilage explants in culture.	tet	4-6	interleukin 1 alpha	Homo sapiens	128-141
9569005-0	1998	Modulation of hormone-dependent glucocorticoid receptor function using a tetracycline-regulated expression system.	tet	73-85	nuclear receptor subfamily 3, group C, member 1	Mus musculus	32-55
9744295-5	1998	Because the constitutive overexpression of SSeCKS is toxic [Lin et al., 1995], we developed cell lines with tetracycline (tet)-regulated SSeCKS expression.	tet	108-120	A-kinase anchoring protein 12	Homo sapiens	43-49
9744295-5	1998	Because the constitutive overexpression of SSeCKS is toxic [Lin et al., 1995], we developed cell lines with tetracycline (tet)-regulated SSeCKS expression.	tet	108-120	A-kinase anchoring protein 12	Homo sapiens	137-143
9744295-5	1998	Because the constitutive overexpression of SSeCKS is toxic [Lin et al., 1995], we developed cell lines with tetracycline (tet)-regulated SSeCKS expression.	tet	108-111	A-kinase anchoring protein 12	Homo sapiens	43-49
9744295-5	1998	Because the constitutive overexpression of SSeCKS is toxic [Lin et al., 1995], we developed cell lines with tetracycline (tet)-regulated SSeCKS expression.	tet	108-111	A-kinase anchoring protein 12	Homo sapiens	137-143
9744295-6	1998	The induction of SSeCKS (removal of tet) caused significant cell flattening and the elaboration of an SSeCKS-associated cortical cytoskeletal matrix resistant to Triton X-100 extraction.	tet	36-39	A-kinase anchoring protein 12	Homo sapiens	17-23
9744295-6	1998	The induction of SSeCKS (removal of tet) caused significant cell flattening and the elaboration of an SSeCKS-associated cortical cytoskeletal matrix resistant to Triton X-100 extraction.	tet	36-39	A-kinase anchoring protein 12	Homo sapiens	102-108
9454891-5	1998	Furthermore, inhibition of kdT beta RII expression by tetracycline treatment led to TGF-beta 1-mediated cell growth arrest in the G1 phase of cell cycle and to the accumulation of the hypophosphorylated form of retinoblastoma (Rb) protein.	tet	54-66	transforming growth factor beta 1	Homo sapiens	84-94
9454891-5	1998	Furthermore, inhibition of kdT beta RII expression by tetracycline treatment led to TGF-beta 1-mediated cell growth arrest in the G1 phase of cell cycle and to the accumulation of the hypophosphorylated form of retinoblastoma (Rb) protein.	tet	54-66	RB transcriptional corepressor 1	Homo sapiens	211-225
9454891-5	1998	Furthermore, inhibition of kdT beta RII expression by tetracycline treatment led to TGF-beta 1-mediated cell growth arrest in the G1 phase of cell cycle and to the accumulation of the hypophosphorylated form of retinoblastoma (Rb) protein.	tet	54-66	RB transcriptional corepressor 1	Homo sapiens	227-229
9551965-4	1998	Using a Jurkat T cell line transfected with dominant active (DA)-mitogen-activated protein kinase kinase kinase (MEKK1) in a tetracycline-regulated expression system, we found that expression of DA-MEKK1 results in the apoptosis of Jurkat cells in parallel with prolonged JNK activation.	tet	125-137	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	113-118
9551965-4	1998	Using a Jurkat T cell line transfected with dominant active (DA)-mitogen-activated protein kinase kinase kinase (MEKK1) in a tetracycline-regulated expression system, we found that expression of DA-MEKK1 results in the apoptosis of Jurkat cells in parallel with prolonged JNK activation.	tet	125-137	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	198-203
9551965-4	1998	Using a Jurkat T cell line transfected with dominant active (DA)-mitogen-activated protein kinase kinase kinase (MEKK1) in a tetracycline-regulated expression system, we found that expression of DA-MEKK1 results in the apoptosis of Jurkat cells in parallel with prolonged JNK activation.	tet	125-137	mitogen-activated protein kinase 8	Homo sapiens	272-275
9569005-3	1998	The intracellular concentration of rGR in E8.2/GR3 cells--from undetectable levels to levels more than 10-fold greater than that observed in wild-type L929 cells--could be manipulated by varying the Tc concentration in the culture media.	tet	199-201	retinal G protein coupled receptor	Rattus norvegicus	35-38
9569005-4	1998	Similarly, dexamethasone (DEX)-dependent transactivation of the mouse mammary tumor virus long terminal repeat and transrepression of the cadmium-induced activity of the mouse heme oxygenase-1 gene enhancer, SX2, were strictly dependent on the presence of rGR, and the levels of these activities could be modulated by Tc.	tet	318-320	heme oxygenase 1	Mus musculus	176-192
9470171-1	1998	Some tetracycline (TC) antibiotics, including TC and anhydrotetracycline, have been found to enhance specific binding of low density lipoprotein (LDL) to both LDL receptor-positive and -negative cells at relatively higher concentrations.	tet	5-17	low density lipoprotein receptor	Homo sapiens	159-171
9470171-1	1998	Some tetracycline (TC) antibiotics, including TC and anhydrotetracycline, have been found to enhance specific binding of low density lipoprotein (LDL) to both LDL receptor-positive and -negative cells at relatively higher concentrations.	tet	19-21	low density lipoprotein receptor	Homo sapiens	159-171
9470171-1	1998	Some tetracycline (TC) antibiotics, including TC and anhydrotetracycline, have been found to enhance specific binding of low density lipoprotein (LDL) to both LDL receptor-positive and -negative cells at relatively higher concentrations.	tet	46-48	low density lipoprotein receptor	Homo sapiens	159-171
9470171-2	1998	When incubated at 37 degrees C, the ability of LDL receptor-negative human fibroblasts to bind 125I-LDL was increased from < 2 to 45 ng/mg by 170 microM TC.	tet	156-158	low density lipoprotein receptor	Homo sapiens	47-59
9550385-1	1997	A chimeric TCR gene, comprising an anti-hapten single-chain Ab variable fragment fused to the transmembrane and cytoplasmic regions of the human TCR zeta-chain, was used to determine whether the tetracycline-regulatable system could be used to regulate gene expression in T cells.	tet	195-207	CD247 molecule	Homo sapiens	145-159
9407973-1	1997	In the present investigation, we have transfected a human malignant glioma cell line, U-1242 MG, and derived clones that produce transforming growth factor alpha (TGF-alpha) in an inducible manner using the tetracycline suppressible vector system.	tet	207-219	tumor necrosis factor	Homo sapiens	129-161
9407973-1	1997	In the present investigation, we have transfected a human malignant glioma cell line, U-1242 MG, and derived clones that produce transforming growth factor alpha (TGF-alpha) in an inducible manner using the tetracycline suppressible vector system.	tet	207-219	transforming growth factor alpha	Homo sapiens	163-172
9368008-4	1997	We applied a conditional mRNA depletion strategy of HER-2/neu with anti-HER-2/neu-targeted hammerhead ribozymes expressed under the control of a tetracycline-regulated promoter system.	tet	145-157	erb-b2 receptor tyrosine kinase 2	Homo sapiens	72-77
9455907-3	1997	To further explore this phenomenon in detail, we applied tetracycline-regulated system to control the expression of GD3 synthase cDNA in Neuro2a cells.	tet	57-69	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	116-128
9368008-4	1997	We applied a conditional mRNA depletion strategy of HER-2/neu with anti-HER-2/neu-targeted hammerhead ribozymes expressed under the control of a tetracycline-regulated promoter system.	tet	145-157	erb-b2 receptor tyrosine kinase 2	Homo sapiens	78-81
9399646-3	1997	We demonstrate here that reexpression of functional pRB alone in RB/p53-defective tumor cells via a modified tetracycline-regulated gene expression system resulted in a stable growth arrest at the G0/G1 phase of the cell cycle, preventing tumor cells from entering S phase in response to a variety of mitogenic stimuli.	tet	109-121	RB transcriptional corepressor 1	Homo sapiens	52-55
9351829-8	1997	Using a tetracycline-regulated LMP-1 allele, we demonstrate that JNK is also an effector of non-cytotoxic LMP-1 signaling in B cells, the physiological target cells of EBV.	tet	8-20	PDZ and LIM domain 7	Homo sapiens	31-36
9351829-8	1997	Using a tetracycline-regulated LMP-1 allele, we demonstrate that JNK is also an effector of non-cytotoxic LMP-1 signaling in B cells, the physiological target cells of EBV.	tet	8-20	mitogen-activated protein kinase 8	Homo sapiens	65-68
9351829-8	1997	Using a tetracycline-regulated LMP-1 allele, we demonstrate that JNK is also an effector of non-cytotoxic LMP-1 signaling in B cells, the physiological target cells of EBV.	tet	8-20	PDZ and LIM domain 7	Homo sapiens	106-111
22358879-2	1997	In this system, the transcription of hIL-6 gene under the control of PhCMV*-1 promoter composed of tetracycline operator sequences and a minimal promoter is activated by a chimeric transactivator (tTA) composed of tetracycline repressor and transactivating domain of VP16 protein of herpes simplex virus.	tet	99-111	interleukin 6	Homo sapiens	37-42
22358879-2	1997	In this system, the transcription of hIL-6 gene under the control of PhCMV*-1 promoter composed of tetracycline operator sequences and a minimal promoter is activated by a chimeric transactivator (tTA) composed of tetracycline repressor and transactivating domain of VP16 protein of herpes simplex virus.	tet	214-226	interleukin 6	Homo sapiens	37-42
22358879-5	1997	In the presence of tetracycline, the tTA transactivators can not bind to PhCMV*-1 promoter, therefore, the expression of hIL-6 and tTA gene is suppressed, and the pX will not activate basal transcription.	tet	19-31	interleukin 6	Homo sapiens	121-126
22358879-8	1997	Furthermore, the hIL-6 production is stringently regulated by tetracycline.	tet	62-74	interleukin 6	Homo sapiens	17-22
9343416-1	1997	A tetracycline-regulated system was used to characterize the effects of c-Rel on cell proliferation.	tet	2-14	REL proto-oncogene, NF-kB subunit	Homo sapiens	72-77
9349265-2	1997	Regulation of tRNA expression by the tetracycline repressor (tetR) occurred from genes with the tetO inserted at position -1 (for the tRNA(Trp)AUC gene), or at positions -2, -6 and -10 (for the tRNA(Lys)AUC gene), and repression reached 90%.	tet	37-49	trnG-GCC	Daucus carota	134-146
9346961-9	1997	The specificity of the effect of wild-type p53 on nucleotide excision repair was demonstrated in a p53 homozygous mutant cell line containing a tetracycline-regulated wild-type p53 gene.	tet	144-156	tumor protein p53	Homo sapiens	43-46
9346961-9	1997	The specificity of the effect of wild-type p53 on nucleotide excision repair was demonstrated in a p53 homozygous mutant cell line containing a tetracycline-regulated wild-type p53 gene.	tet	144-156	tumor protein p53	Homo sapiens	99-102
9346961-9	1997	The specificity of the effect of wild-type p53 on nucleotide excision repair was demonstrated in a p53 homozygous mutant cell line containing a tetracycline-regulated wild-type p53 gene.	tet	144-156	tumor protein p53	Homo sapiens	99-102
9346961-10	1997	Wild-type p53 expression and activity were suppressed in the presence of tetracycline, whereas withdrawal of tetracycline resulted in the induction of p53 expression, cell cycle checkpoint activation, and DNA damage-induced apoptosis.	tet	73-85	tumor protein p53	Homo sapiens	10-13
9346961-10	1997	Wild-type p53 expression and activity were suppressed in the presence of tetracycline, whereas withdrawal of tetracycline resulted in the induction of p53 expression, cell cycle checkpoint activation, and DNA damage-induced apoptosis.	tet	109-121	tumor protein p53	Homo sapiens	151-154
9356333-4	1997	Using constitutive and tetracycline-repressible systems to express the ER-targeted antibody against IL-2Ralpha, we have reduced cell surface expression of IL-2Ralpha by more that 2 logs of mean fluorescence intensity to virtually undetectable levels in the IL-2-independent HTLV-I-transformed cell lines C8166-45 and HUT102.	tet	23-35	interleukin 2 receptor subunit alpha	Homo sapiens	100-110
9366521-5	1997	Induction of p16, p21 or p27, using the tetracycline repressor system, potently inhibits proliferation of U343 cells.	tet	40-52	cyclin dependent kinase inhibitor 2A	Homo sapiens	13-16
9366521-5	1997	Induction of p16, p21 or p27, using the tetracycline repressor system, potently inhibits proliferation of U343 cells.	tet	40-52	cyclin dependent kinase inhibitor 1A	Homo sapiens	18-21
9366521-5	1997	Induction of p16, p21 or p27, using the tetracycline repressor system, potently inhibits proliferation of U343 cells.	tet	40-52	interferon alpha inducible protein 27	Homo sapiens	25-28
9325299-1	1997	The INS-r3-GK27 insulinoma cells are endowed with artificially inducible glucokinase under control of the reverse tetracycline-dependent transcriptional activator.	tet	114-126	glucokinase	Rattus norvegicus	73-84
9312072-3	1997	Using a tetracycline-controlled expression system in conjunction with a dominant-negative EGFR mutant, we demonstrate that depolarization and bradykinin triggered signals involve EGFR function upstream of SHC and MAP kinase.	tet	8-20	epidermal growth factor receptor	Rattus norvegicus	179-183
9299553-4	1997	Therefore we adopted a self-contained tetracycline-regulated expression system to acquire an rAdv expressing hGDNF.	tet	38-50	glial cell derived neurotrophic factor	Homo sapiens	109-114
9333018-2	1997	To further characterize the potential targets of IRF-1 antiproliferative activity, IRF-1 was expressed under the control of the tetracycline-inducible system in murine NIH3T3 cells.	tet	128-140	interferon regulatory factor 1	Mus musculus	83-88
18636602-3	1997	Such a cytostatic production phase is established by overexpression of the tumor suppressor genes p21, p27, or p53175P (a p53 mutant showing specific loss of apoptotic function) under transcriptional control of a tetracycline-repressible promoter (P(hCMV*-1)).	tet	213-225	cellular tumor antigen p53	Cricetulus griseus	111-114
9307273-1	1997	In this study, we used a self-contained tetracycline-regulated retroviral vector system to elucidate the role of vascular endothelial growth factor (VEGF) in controlling s.c. growth of human T-47D breast carcinoma cells.	tet	40-52	vascular endothelial growth factor A	Homo sapiens	113-147
9307273-1	1997	In this study, we used a self-contained tetracycline-regulated retroviral vector system to elucidate the role of vascular endothelial growth factor (VEGF) in controlling s.c. growth of human T-47D breast carcinoma cells.	tet	40-52	vascular endothelial growth factor A	Homo sapiens	149-153
9282322-3	1997	When the carboxyl portion of mitosin containing amino acids 2,094-3,113 (named mitosin-pTN) was stably expressed in rat fibroblast Rat2 cells using a tetracycline-inducible system, strong spindle pole association was observed in addition to expected centromere localization.	tet	150-162	pleiotrophin	Rattus norvegicus	87-90
9271409-1	1997	Resistance to stress-induced apoptosis was examined in cells in which the expression of hsp70 was either constitutively elevated or inducible by a tetracycline-regulated transactivator.	tet	147-159	heat shock protein family A (Hsp70) member 4	Homo sapiens	88-93
9356333-4	1997	Using constitutive and tetracycline-repressible systems to express the ER-targeted antibody against IL-2Ralpha, we have reduced cell surface expression of IL-2Ralpha by more that 2 logs of mean fluorescence intensity to virtually undetectable levels in the IL-2-independent HTLV-I-transformed cell lines C8166-45 and HUT102.	tet	23-35	interleukin 2 receptor subunit alpha	Homo sapiens	155-165
9349426-2	1997	We constructed a new amplicon vector, pHermes-tet-lacZ, that carries the bacterial beta-galactosidase (lacZ) gene under the control of a minimal promoter preceded by a heptameric tetracycline operator.	tet	179-191	galactosidase, beta 1	Mus musculus	83-101
9271424-8	1997	Similarly, the induction of expression of FIN13 under the control of a tetracycline-regulated promoter in NIH 3T3 cells leads to growth inhibition, with accumulation of cells in G1 and early S phases.	tet	71-83	protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform	Mus musculus	42-47
9269991-5	1997	Expression of TNF-alpha in the transduced cells was nondetectable when the culture medium contained as little as 0.1 microg/ml of Tc.	tet	130-132	tumor necrosis factor	Homo sapiens	14-23
9271434-9	1997	Similar to induction of Raf, a strong induction of activated Ras via a tetracycline-dependent promoter also causes inhibition of proliferation and p21Cip1 induction at high expression levels.	tet	71-83	zinc fingers and homeoboxes 2	Mus musculus	24-27
9271434-9	1997	Similar to induction of Raf, a strong induction of activated Ras via a tetracycline-dependent promoter also causes inhibition of proliferation and p21Cip1 induction at high expression levels.	tet	71-83	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	147-154
9259408-4	1997	By generating stable transfectants of C6 glioma cells that express mIL-4 under a tetracycline-responsive promoter system, we were able to apply tight regulatory control of mIL-4 expression in vivo.	tet	81-93	interleukin 4	Mus musculus	67-72
9259408-4	1997	By generating stable transfectants of C6 glioma cells that express mIL-4 under a tetracycline-responsive promoter system, we were able to apply tight regulatory control of mIL-4 expression in vivo.	tet	81-93	interleukin 4	Mus musculus	172-177
9238051-3	1997	Using a tetracycline-regulated VEGF expression system in xenografted C6 glioma cells, we showed that shutting off VEGF production leads to detachment of endothelial cells from the walls of preformed vessels and their subsequent death by apoptosis.	tet	8-20	vascular endothelial growth factor A	Homo sapiens	31-35
9296393-0	1997	Tetracycline regulated expression of vimentin in fibroblasts derived from vimentin null mice.	tet	0-12	vimentin	Mus musculus	37-45
9238051-3	1997	Using a tetracycline-regulated VEGF expression system in xenografted C6 glioma cells, we showed that shutting off VEGF production leads to detachment of endothelial cells from the walls of preformed vessels and their subsequent death by apoptosis.	tet	8-20	vascular endothelial growth factor A	Homo sapiens	114-118
9296393-0	1997	Tetracycline regulated expression of vimentin in fibroblasts derived from vimentin null mice.	tet	0-12	vimentin	Mus musculus	74-82
9296393-1	1997	Fibroblast cell lines were derived from vim-/- mice that express a mouse vimentin transgene in a tetracycline regulatable manner.	tet	97-109	vimentin	Mus musculus	73-81
9185531-6	1997	Using cells in which deltaFosB or FosB expression is under the control of a tetracycline-regulated gene expression system, we show that the 37 kDa deltaFosB protein exhibits a remarkably long half-life, the 35 kDa DeltaFosB protein exhibits an intermediate half-life, and the 33 kDa deltaFosB protein and all FosB-derived proteins exhibit relatively short half-lives.	tet	76-88	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-30
9247304-4	1997	We used the tetracycline repressible vector system and obtained two stably transfected clones that expressed p16INK4A upon induction.	tet	12-24	cyclin dependent kinase inhibitor 2A	Homo sapiens	109-117
9247304-7	1997	This senescence phenotype was dependent on the continuous expression of p16INK4A since it was reversed upon reintroduction of tetracycline suppression.	tet	126-138	cyclin dependent kinase inhibitor 2A	Homo sapiens	72-80
9185531-6	1997	Using cells in which deltaFosB or FosB expression is under the control of a tetracycline-regulated gene expression system, we show that the 37 kDa deltaFosB protein exhibits a remarkably long half-life, the 35 kDa DeltaFosB protein exhibits an intermediate half-life, and the 33 kDa deltaFosB protein and all FosB-derived proteins exhibit relatively short half-lives.	tet	76-88	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-38
9191053-2	1997	To address the relationship between cyclin D1 and other cell cycle regulatory proteins, we established human glioma and rodent fibroblast cell lines in which cyclin D1 expression could be regulated ectopically with tetracycline.	tet	215-227	cyclin D1	Homo sapiens	158-167
9267432-2	1997	Tetracycline-responsive promoters were constructed by fusing the tetracycline operator (tetO) to the S. cerevisiae HOP1 promoter.	tet	0-12	Hop1p	Saccharomyces cerevisiae S288C	115-119
9267432-3	1997	When fused to the tetracycline repressor (tetR), trans-activation domains of both GAL4 and HAP4 were capable of promoting transcription from the tetO-HOP1 chimeric promoter, but the tetR-HAP4 fusion activator was the more efficient transcriptional activator.	tet	18-30	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	82-86
9267432-3	1997	When fused to the tetracycline repressor (tetR), trans-activation domains of both GAL4 and HAP4 were capable of promoting transcription from the tetO-HOP1 chimeric promoter, but the tetR-HAP4 fusion activator was the more efficient transcriptional activator.	tet	18-30	transcription factor HAP4	Saccharomyces cerevisiae S288C	91-95
9267432-4	1997	Addition of tetracycline nearly completely repressed activator-dependent transcription from the tetO-HOP1 promoter.	tet	12-24	Hop1p	Saccharomyces cerevisiae S288C	101-105
9267432-5	1997	Moreover, tetracycline-dependent repression of YEF3, CDC28 and RAM2 expression impaired cell growth.	tet	10-22	translation elongation factor EF-3	Saccharomyces cerevisiae S288C	47-51
9267432-5	1997	Moreover, tetracycline-dependent repression of YEF3, CDC28 and RAM2 expression impaired cell growth.	tet	10-22	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	53-58
9267432-5	1997	Moreover, tetracycline-dependent repression of YEF3, CDC28 and RAM2 expression impaired cell growth.	tet	10-22	bifunctional protein farnesyltransferase/protein geranylgeranyltransferase	Saccharomyces cerevisiae S288C	63-67
21533508-2	1997	We have previously generated stable transfectants of C6 glioma cells that express mouse IL-4 (mIL-4) under a tetracycline-responsive promoter system, enabling us to apply tight regulatory control of mIL-4 expression in vivo.	tet	109-121	interleukin 4	Mus musculus	88-92
21533508-2	1997	We have previously generated stable transfectants of C6 glioma cells that express mouse IL-4 (mIL-4) under a tetracycline-responsive promoter system, enabling us to apply tight regulatory control of mIL-4 expression in vivo.	tet	109-121	interleukin 4	Mus musculus	94-99
21533508-2	1997	We have previously generated stable transfectants of C6 glioma cells that express mouse IL-4 (mIL-4) under a tetracycline-responsive promoter system, enabling us to apply tight regulatory control of mIL-4 expression in vivo.	tet	109-121	interleukin 4	Mus musculus	199-204
9191059-2	1997	Induction of activated K-ras by Tet withdrawal accelerated cell growth and entry into S-phase.	tet	32-35	KRAS proto-oncogene, GTPase	Homo sapiens	23-28
9139748-5	1997	Treatment with tetracycline suppressed RIII expression and abolished TGFbeta1 binding to RI and RII.	tet	15-27	transforming growth factor beta 1	Homo sapiens	69-77
9269991-0	1997	Development of an adenovirus vector with tetracycline-regulatable human tumor necrosis factor alpha gene expression.	tet	41-53	tumor necrosis factor	Homo sapiens	72-99
9269991-3	1997	We have recently modified a tetracycline (Tc) repressor/operator-based mammalian gene expression system and have generated a Tc-responsive recombinant adenovirus vector, AdVtTA.TNF-alpha.	tet	28-40	tumor necrosis factor	Homo sapiens	177-186
9269991-3	1997	We have recently modified a tetracycline (Tc) repressor/operator-based mammalian gene expression system and have generated a Tc-responsive recombinant adenovirus vector, AdVtTA.TNF-alpha.	tet	42-44	tumor necrosis factor	Homo sapiens	177-186
9269991-3	1997	We have recently modified a tetracycline (Tc) repressor/operator-based mammalian gene expression system and have generated a Tc-responsive recombinant adenovirus vector, AdVtTA.TNF-alpha.	tet	125-127	tumor necrosis factor	Homo sapiens	177-186
9269991-4	1997	A variety of human tumor cells and T lymphocytes transduced by AdVtTA.TNF-alpha secreted high-titer (5,000-100,000 pg/10(6) cells/24 h) and biologically active TNF-alpha in the absence of Tc.	tet	188-190	tumor necrosis factor	Homo sapiens	70-79
9139801-13	1997	This effect does not obtain in L929 mutants that are null for the glucocorticoid receptor, and a variant that expresses the glucocorticoid receptor from a tetracycline-repressible expression vector demonstrates induction of p21 mRNA only in the absence of tetracycline.	tet	155-167	nuclear receptor subfamily 3, group C, member 1	Mus musculus	124-147
9139801-13	1997	This effect does not obtain in L929 mutants that are null for the glucocorticoid receptor, and a variant that expresses the glucocorticoid receptor from a tetracycline-repressible expression vector demonstrates induction of p21 mRNA only in the absence of tetracycline.	tet	155-167	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	224-227
9139801-13	1997	This effect does not obtain in L929 mutants that are null for the glucocorticoid receptor, and a variant that expresses the glucocorticoid receptor from a tetracycline-repressible expression vector demonstrates induction of p21 mRNA only in the absence of tetracycline.	tet	256-268	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	224-227
9139801-16	1997	This effect can be blocked by tetracycline-mediated repression of the glucocorticoid receptor.	tet	30-42	nuclear receptor subfamily 3, group C, member 1	Mus musculus	70-93
9110991-4	1997	For regulated expression of PS2, we have established inducible cell lines expressing PS2 under the tight control of the tetracycline-responsive transactivator.	tet	120-132	presenilin 2	Homo sapiens	28-31
9110991-4	1997	For regulated expression of PS2, we have established inducible cell lines expressing PS2 under the tight control of the tetracycline-responsive transactivator.	tet	120-132	presenilin 2	Homo sapiens	85-88
9150394-0	1997	Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells.	tet	74-86	tumor protein p53	Homo sapiens	107-110
9949290-7	1997	Using tumor cell lines relevant to bone metastases, i.e. PC-3, MDA-MB-231, Hs696, B16/F1, we showed that tetracycline and derivatives of tetracycline, namely doxycycline and minocycline, also induced cytotoxicity.	tet	105-117	keratin 6A	Homo sapiens	57-61
9102209-4	1997	Elevated expression of ING1 in P19 and rodent fibroblast cells containing a tetracycline-controlled human c-myc gene enhanced the extent of serum starvation-induced apoptosis.	tet	76-88	inhibitor of growth family member 1	Homo sapiens	23-27
9102209-4	1997	Elevated expression of ING1 in P19 and rodent fibroblast cells containing a tetracycline-controlled human c-myc gene enhanced the extent of serum starvation-induced apoptosis.	tet	76-88	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	106-111
9154297-7	1997	Tissue factor expression was enhanced even in the presence of tetracycline, suggesting that the chlamydial factor responsible for stimulating synthesis of endothelial cell tissue factor was preformed.	tet	62-74	coagulation factor III, tissue factor	Homo sapiens	0-13
9079651-4	1997	Early passage MCF-7 cells, which exhibit detectable type II TGF-beta receptors at the cell surface and exquisite sensitivity to exogenous TGF-beta1, were transfected with a tetracycline-controllable dominant-negative TGF-betaRII (DeltaRII) construct.	tet	173-185	transforming growth factor beta receptor 2	Homo sapiens	217-228
9079651-5	1997	Although the TGF-beta1 response was blocked by removal of tetracycline in MCF-7/DeltaRII cells, tamoxifen-mediated suppression of Rb phosphorylation, recruitment in G1, and inhibition of cell proliferation were identical in the presence and absence of tetracycline.	tet	58-70	transforming growth factor beta 1	Homo sapiens	13-22
9089284-4	1997	We employed the widely applied tetracycline-controlled transactivator system (tTA) to study the regulation of vWF mRNA synthesis in stably transfected Madin Darby kidney (MDCK-II) cells in a quantitative manner.	tet	31-43	von Willebrand factor	Canis lupus familiaris	110-113
9089284-5	1997	Immunofluorescence staining with anti-vWF antibodies revealed that increasing the concentration of tetracycline resulted in a decreased number of MDCK-II cells that synthesize vWF.	tet	99-111	von Willebrand factor	Canis lupus familiaris	38-41
9089284-5	1997	Immunofluorescence staining with anti-vWF antibodies revealed that increasing the concentration of tetracycline resulted in a decreased number of MDCK-II cells that synthesize vWF.	tet	99-111	von Willebrand factor	Canis lupus familiaris	176-179
9121768-2	1997	A dominant negative mutant (E2F97) of E2F1 containing the DNA binding domain of E2F1 under the control of a tetracycline-responsive promoter was constructed.	tet	108-120	E2F transcription factor 1	Homo sapiens	38-42
9121768-2	1997	A dominant negative mutant (E2F97) of E2F1 containing the DNA binding domain of E2F1 under the control of a tetracycline-responsive promoter was constructed.	tet	108-120	E2F transcription factor 1	Homo sapiens	80-84
9045812-4	1997	To investigate this possibility, a second mutational target was created on the Lac- episome by mutation of a Tn1O element, which encodes tetracycline resistance (Tetr), to tetracycline sensitivity (Tets).	tet	137-149	tetracycline resistance repressor protein TetR	Escherichia coli	162-166
9045812-4	1997	To investigate this possibility, a second mutational target was created on the Lac- episome by mutation of a Tn1O element, which encodes tetracycline resistance (Tetr), to tetracycline sensitivity (Tets).	tet	172-184	tetracycline resistance repressor protein TetR	Escherichia coli	162-166
9018061-4	1997	Tetracycline-regulated Nef expression was achieved in HeLa cells but could not be established in human T cell lines.	tet	0-12	TNFAIP3 interacting protein 1	Mus musculus	23-26
8999911-3	1997	A tetracycline-responsive system was used to induce overexpression of the TfR up to 20-fold in HeLa cells.	tet	2-14	transferrin receptor	Homo sapiens	74-77
9017423-9	1997	Myotubes differentiation induced tTA expression, leading to a 28-fold increase of Epo mRNAs, which was suppressed by tetracycline.	tet	117-129	erythropoietin	Mus musculus	82-85
9017423-10	1997	Basal Epo secretion in myoblasts increased 23- to 41-fold during the formation of multinucleated myotubes, and turned back close to myoblast level when tetracycline was added.	tet	152-164	erythropoietin	Mus musculus	6-9
9000505-7	1997	In contrast, tetracycline-regulated overexpression of Bcl-2 protected CEM-C7H2 sublines stably transfected with corresponding constructs from ceramide-induced apoptosis.	tet	13-25	BCL2 apoptosis regulator	Homo sapiens	54-59
9949290-7	1997	Using tumor cell lines relevant to bone metastases, i.e. PC-3, MDA-MB-231, Hs696, B16/F1, we showed that tetracycline and derivatives of tetracycline, namely doxycycline and minocycline, also induced cytotoxicity.	tet	137-149	keratin 6A	Homo sapiens	57-61
9085232-2	1997	Based on tetracycline (TTC) ability to bind divalent metal ions, the present study was designed to examine the effect of TTC on P. gingivalis LPS-induced lesions in vivo and on LPS-induced TNF alpha production in vitro.	tet	9-21	tumor necrosis factor	Homo sapiens	189-198
8968096-0	1996	Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells.	tet	24-36	caspase 1	Rattus norvegicus	61-87
8957085-5	1996	We have used rat fibroblast cell lines capable of expressing cyclin E, cyclin D1, or both, in an inducible manner, through a tetracycline responsive promoter.	tet	125-137	cyclin E1	Rattus norvegicus	61-69
8957085-5	1996	We have used rat fibroblast cell lines capable of expressing cyclin E, cyclin D1, or both, in an inducible manner, through a tetracycline responsive promoter.	tet	125-137	cyclin D1	Rattus norvegicus	71-80
8968096-0	1996	Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells.	tet	24-36	caspase 1	Rattus norvegicus	89-92
8968096-3	1996	By delivering the ICE-lacZ gene within a retroviral vector and under the control of a tetracycline-regulated promoter, we were able to utilize the intrinsic cell death program of ICE as a means for tumoricidal therapy in a rat brain tumor model.	tet	86-98	caspase 1	Rattus norvegicus	179-182
8968096-4	1996	Both in culture and in vivo suppression of ICE-lacZ expression was extremely tight in the presence of tetracycline, as determined by the lack of X-galactosidase-positive tumor cells and by cell viability.	tet	102-114	caspase 1	Rattus norvegicus	43-46
8968096-5	1996	When tetracycline was withdrawn, ICE-lacZ gene expression was rapidly turned on and apoptosis-mediated cell death occurred in essentially all tumor cells.	tet	5-17	caspase 1	Mus musculus	33-36
8958991-4	1996	Recent studies using MMP-inhibiting tetracycline derivatives in the elastase-induced rodent model of AAA indicate that metalloproteinase suppression is a feasible and successful approach in the experimental setting.	tet	36-48	AAA1	Homo sapiens	101-104
8940065-1	1996	Functional membrane insertion elements in the pBR322 tetracycline resistance protein were identified by comparing the ability of odd-numbered transmembrane segments and their attached periplasmic loops to insert into the membrane individually or when combined with the next even-numbered segment in the tetracycline resistance protein sequence.	tet	53-65	translocator protein	Homo sapiens	46-49
8940065-1	1996	Functional membrane insertion elements in the pBR322 tetracycline resistance protein were identified by comparing the ability of odd-numbered transmembrane segments and their attached periplasmic loops to insert into the membrane individually or when combined with the next even-numbered segment in the tetracycline resistance protein sequence.	tet	303-315	translocator protein	Homo sapiens	46-49
8895660-5	1996	We show that addition of tet to these cells results in rapid depletion of ASF/SF2, concomitant accumulation of incompletely processed pre-mRNA, and subsequent cell death.	tet	25-28	serine and arginine rich splicing factor 1	Homo sapiens	74-81
8827073-4	1996	To further characterize the functional properties of WT1, multiple U2OS and Saos-2 cell lines were established, expressing either wild-type WT1 splicing variants or naturally occurring mutants under control of a tightly regulated tetracycline repressable promoter.	tet	230-242	WT1 transcription factor	Homo sapiens	53-56
8895660-6	1996	The tet-induced lethality could be rescued by plasmids expressing wild-type ASF/SF2, but not several mutant derivatives, or other SR proteins.	tet	4-7	serine and arginine rich splicing factor 1	Homo sapiens	76-83
8754811-3	1996	Using a tetracycline-responsive expression system, we have recently shown that the conditional ectopic expression of C/EBPbeta in NIH 3T3 fibroblasts (beta2 cells) in the presence of DEX activates the synthesis of peroxisome PPARgamma mRNA.	tet	8-20	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	117-126
8876147-3	1996	Because constitutive expression of the VSV-G protein is toxic in 293 cells, we used the tetR/VP 16 transactivator and teto minimal promoter system for inducible, tetracycline-regulatable expression of VSV-G. After stable transfection of the 293GPG packaging cell line with the MFG.SnlsLacZ retroviral vector construct, it was possible to readily isolate stable virus-producing cell lines with titers approaching 10(7) colony-forming units/ml.	tet	162-174	host cell factor C1	Homo sapiens	93-98
8806679-2	1996	Cell lines expressing HER2 under control of a tetracycline-responsive promoter were isolated.	tet	46-58	erb-b2 receptor tyrosine kinase 2	Mus musculus	22-26
8891931-0	1996	The effect of tetracycline fiber therapy on beta-glucuronidase and interleukin-1 beta in crevicular fluid.	tet	14-26	interleukin 1 beta	Homo sapiens	67-85
8884643-9	1996	While the GCF TIMP level did not change significantly in the scaling and root planing alone group, it significantly increased for all three adjunctive antimicrobial treatments (for tetracycline fiber P < 0.001, minocycline gel P = 0.005, metronidazole gel P < 0.001).	tet	181-193	TIMP metallopeptidase inhibitor 1	Homo sapiens	14-18
8806537-1	1996	Tetracycline-regulated vectors were used to obtain inducible expression in stable transfected B cell lines of two Epstein-Barr virus (EBV) latent genes, LMP1 and EBNA2.	tet	0-12	LMP1	Human gammaherpesvirus 4	153-157
8806537-1	1996	Tetracycline-regulated vectors were used to obtain inducible expression in stable transfected B cell lines of two Epstein-Barr virus (EBV) latent genes, LMP1 and EBNA2.	tet	0-12	EBNA-2	Human gammaherpesvirus 4	162-167
8761302-1	1996	To elucidate the contribution of the N-Myc protein to neuroblastomas we have used a synthetic inducible expression system on the basis of the tetracycline repressor of E coli to reversibly express N-myc in a human neuroblastoma cell line in which expression of endogenous N-myc is barely detectable.	tet	142-154	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	197-202
8754843-5	1996	A tetracycline-responsive form of the aprt gene was used to compare the stability of nonsense-containing and wild-type aprt mRNAs without globally inhibiting transcription.	tet	2-14	adenine phosphoribosyltransferase	Cricetulus griseus	38-42
8754843-6	1996	In contrast to measurements made in the presence of actinomycin D, after inhibition of aprt transcription with tetracycline, a nonsense-mediated destabilization of aprt mRNA was indeed demonstrable.	tet	111-123	adenine phosphoribosyltransferase	Cricetulus griseus	87-91
8754811-3	1996	Using a tetracycline-responsive expression system, we have recently shown that the conditional ectopic expression of C/EBPbeta in NIH 3T3 fibroblasts (beta2 cells) in the presence of DEX activates the synthesis of peroxisome PPARgamma mRNA.	tet	8-20	peroxisome proliferator activated receptor gamma	Mus musculus	225-234
8754811-7	1996	Culture of these cells in tetracycline-deficient medium containing DEX, MIX, insulin, and fetal bovine serum shows that the beta/delta39 cells express PPARgamma and aP2 mRNAs at levels that are almost equivalent to those observed in fully differentiated 3T3-L1 adipocytes.	tet	26-38	peroxisome proliferator activated receptor gamma	Mus musculus	151-160
8754811-7	1996	Culture of these cells in tetracycline-deficient medium containing DEX, MIX, insulin, and fetal bovine serum shows that the beta/delta39 cells express PPARgamma and aP2 mRNAs at levels that are almost equivalent to those observed in fully differentiated 3T3-L1 adipocytes.	tet	26-38	transcription factor AP-2, alpha	Mus musculus	165-168
8760877-1	1996	To understand the parameters required for designing potent and specific antisense C-5 propynyl-pyrimidine-2"-deoxyphosphorothioate-modified oligonucleotides (C-5 propyne ONs), we have utilized a HeLa line that stably expresses luciferase under tight control of a tetracycline-responsive promoter.	tet	263-275	complement C5	Homo sapiens	82-85
8760877-1	1996	To understand the parameters required for designing potent and specific antisense C-5 propynyl-pyrimidine-2"-deoxyphosphorothioate-modified oligonucleotides (C-5 propyne ONs), we have utilized a HeLa line that stably expresses luciferase under tight control of a tetracycline-responsive promoter.	tet	263-275	complement C5	Homo sapiens	158-161
8663343-4	1996	Stable transfection of a tetracycline-regulatable rat RI cDNA increased TGFbeta1 binding to RI and resulted in increased growth inhibition by exogenous TGFbeta1.	tet	25-37	transforming growth factor, beta 1	Rattus norvegicus	72-80
8663343-4	1996	Stable transfection of a tetracycline-regulatable rat RI cDNA increased TGFbeta1 binding to RI and resulted in increased growth inhibition by exogenous TGFbeta1.	tet	25-37	transforming growth factor, beta 1	Rattus norvegicus	152-160
8667413-1	1996	The naturally occurring plasmid pSTS7 from Staphylococcus epidermidis mediated resistance to tetracycline via a tetL gene and to kanamycin and neomycin via an aadD gene.	tet	93-105	tetracycline resistance protein	Staphylococcus epidermidis	112-116
8703989-1	1996	Selected domains of the regulatory p85 subunit of phosphatidylinositol 3-kinase have been expressed under the control of the tetracycline transactivator in NIH 3T3 fibroblasts transformed by the v-Ha-Ras oncogene.	tet	125-137	extracellular matrix protein 1	Mus musculus	35-38
8693003-8	1996	However, following withdrawal of Tc from culture media, expression of beta-galactosidase was induced within 24 h. When Tc was again added, the expression was rapidly resuppressed.	tet	33-35	galactosidase, beta 1	Rattus norvegicus	70-88
8693003-8	1996	However, following withdrawal of Tc from culture media, expression of beta-galactosidase was induced within 24 h. When Tc was again added, the expression was rapidly resuppressed.	tet	119-121	galactosidase, beta 1	Rattus norvegicus	70-88
8693003-11	1996	In the isolated chimeric glomeruli, expression of beta-galactosidase was induced ex vivo in the absence of Tc, whereas it was repressed in its presence.	tet	107-109	galactosidase, beta 1	Rattus norvegicus	50-68
8693003-12	1996	When Tc-pretreated MtTAG cells were transferred into the glomeruli of untreated rats, beta-galactosidase expression was induced in vivo within 3 days.	tet	5-7	galactosidase, beta 1	Rattus norvegicus	86-104
8690514-4	1996	We transfected bax-alpha into the breast-cancer cell lines R30C and MCF-7 under the control of an inducible tetracycline-dependent expression system.	tet	108-120	BCL2 associated X, apoptosis regulator	Homo sapiens	15-18
8809405-2	1996	To assess the biological significance of p53 inactivation in the development of SCLC, tetracycline (Tc)-inducible p53 expression plasmids were introduced into a SCLC cell line, N417, in which the p53 gene as well as the RB gene was inactivated.	tet	86-98	tumor protein p53	Homo sapiens	114-117
8809405-2	1996	To assess the biological significance of p53 inactivation in the development of SCLC, tetracycline (Tc)-inducible p53 expression plasmids were introduced into a SCLC cell line, N417, in which the p53 gene as well as the RB gene was inactivated.	tet	86-98	tumor protein p53	Homo sapiens	114-117
8809405-2	1996	To assess the biological significance of p53 inactivation in the development of SCLC, tetracycline (Tc)-inducible p53 expression plasmids were introduced into a SCLC cell line, N417, in which the p53 gene as well as the RB gene was inactivated.	tet	100-102	tumor protein p53	Homo sapiens	114-117
8809405-2	1996	To assess the biological significance of p53 inactivation in the development of SCLC, tetracycline (Tc)-inducible p53 expression plasmids were introduced into a SCLC cell line, N417, in which the p53 gene as well as the RB gene was inactivated.	tet	100-102	tumor protein p53	Homo sapiens	114-117
8809405-5	1996	Thus, wild-type p53-inducible clones were further established by transfection in the presence (repressed) of Tc.	tet	109-111	tumor protein p53	Homo sapiens	16-19
8676479-4	1996	The tetracycline-inducible expression system was utilized to control the expression of the Rev regulatory protein, which in turn controls the expression of the late proteins including Gag, Pol, and Env.	tet	4-16	endogenous retrovirus group W member 1, envelope	Homo sapiens	198-201
8832479-9	1996	Pretreatment of diseased cementum with tetracycline (50 mg/ml) was found to block the secretion of TNF alpha from cementum-stimulated monocytes.	tet	39-51	tumor necrosis factor	Homo sapiens	99-108
8832479-11	1996	The direct addition of tetracycline to cementum-stimulated monocyte culture was found to block TNF alpha secretion in a dose dependent manner.	tet	23-35	tumor necrosis factor	Homo sapiens	95-104
8832479-14	1996	In addition, tetracycline was found to be a potent inhibitor of TNF alpha secretion by cementum-stimulated monocytes, suggesting a novel mechanism for this drug in periodontal therapy.	tet	13-25	tumor necrosis factor	Homo sapiens	64-73
8668164-6	1996	Indeed, inducible expression, under control of a tetracycline-regulated promoter, of D404G-TbetaRII in TGF-beta- sensitive Mac-1 cells as well as in Hep3B hepatoma cells results in resistance to TGF-beta and disappearance of cell surface TbetaRI and TbetaRII.	tet	49-61	transforming growth factor beta receptor 2	Homo sapiens	91-99
8668164-6	1996	Indeed, inducible expression, under control of a tetracycline-regulated promoter, of D404G-TbetaRII in TGF-beta- sensitive Mac-1 cells as well as in Hep3B hepatoma cells results in resistance to TGF-beta and disappearance of cell surface TbetaRI and TbetaRII.	tet	49-61	transforming growth factor beta 1	Homo sapiens	103-111
8668164-6	1996	Indeed, inducible expression, under control of a tetracycline-regulated promoter, of D404G-TbetaRII in TGF-beta- sensitive Mac-1 cells as well as in Hep3B hepatoma cells results in resistance to TGF-beta and disappearance of cell surface TbetaRI and TbetaRII.	tet	49-61	integrin subunit alpha M	Homo sapiens	123-128
8668164-6	1996	Indeed, inducible expression, under control of a tetracycline-regulated promoter, of D404G-TbetaRII in TGF-beta- sensitive Mac-1 cells as well as in Hep3B hepatoma cells results in resistance to TGF-beta and disappearance of cell surface TbetaRI and TbetaRII.	tet	49-61	transforming growth factor beta 1	Homo sapiens	195-203
8668164-6	1996	Indeed, inducible expression, under control of a tetracycline-regulated promoter, of D404G-TbetaRII in TGF-beta- sensitive Mac-1 cells as well as in Hep3B hepatoma cells results in resistance to TGF-beta and disappearance of cell surface TbetaRI and TbetaRII.	tet	49-61	transforming growth factor beta receptor 1	Homo sapiens	91-98
8668164-6	1996	Indeed, inducible expression, under control of a tetracycline-regulated promoter, of D404G-TbetaRII in TGF-beta- sensitive Mac-1 cells as well as in Hep3B hepatoma cells results in resistance to TGF-beta and disappearance of cell surface TbetaRI and TbetaRII.	tet	49-61	transforming growth factor beta receptor 2	Homo sapiens	250-258
8661425-1	1996	293 cell lines that inducibly express high levels of adenovirus type 5 precursor terminal protein (pTP) under the control of a tetracycline-dependent promoter were constructed.	tet	127-139	regenerating family member 1 alpha	Homo sapiens	99-102
8647960-6	1996	Furthermore, we transfected bax-alpha into breast cancer cell lines under the control of a tetracycline-dependent expression system.	tet	91-103	BCL2-associated X protein	Mus musculus	28-31
8682308-5	1996	However, this repression could be alleviated by exposure to Tc or IPTG, which inhibited the binding activities of TTA and LacI, respectively.	tet	60-62	tissue factor pathway inhibitor	Homo sapiens	122-126
8682308-9	1996	This suggests that regulation by Tc is fast and that the phenotypic lag may be due to slow turnover of the LacI repressor.	tet	33-35	tissue factor pathway inhibitor	Homo sapiens	107-111
8694578-0	1996	Protection against peroxynitrite dependent tyrosine nitration and alpha 1-antiproteinase inactivation by some anti-inflammatory drugs and by the antibiotic tetracycline.	tet	156-168	serpin family A member 1	Homo sapiens	66-88
8655505-1	1996	Tet(M) protein, which displays homology to elongation factor G (EF-G), interacts with the protein biosynthetic machinery to render this process resistant to tetracycline in vivo and in vitro.	tet	157-169	G elongation factor mitochondrial 1	Homo sapiens	43-62
8837329-8	1996	Other members of the tetracycline family were not oxidized to dark products by the TPO system.	tet	21-33	thyroid peroxidase	Homo sapiens	83-86
8655505-1	1996	Tet(M) protein, which displays homology to elongation factor G (EF-G), interacts with the protein biosynthetic machinery to render this process resistant to tetracycline in vivo and in vitro.	tet	157-169	G elongation factor mitochondrial 1	Homo sapiens	64-68
8655505-7	1996	And, while Tet(M) and EF-G GTPase activities are tetracycline resistant, the two proteins differ in their sensitivities to fusidic acid, with the latter activity inhibited by the drug.	tet	49-61	G elongation factor mitochondrial 1	Homo sapiens	22-26
8643550-10	1996	Tandem tet operator sequences and the cytomegalovirus minimal promoter drive expression of a bicistronic mRNA, leading to transcription of the gene of interest (lacZ) and the internal ribosome entry site controlled transactivator (Tet repressor-VP16 fusion protein).	tet	7-10	host cell factor C1	Homo sapiens	245-249
8807626-9	1996	Osteocalcin and PTH correlated with osteoid thickness, the mineral appositional rate, tetracycline-labelled surface, the adjusted apposition rate, mineralization lag time and the bone formation rates.	tet	86-98	bone gamma-carboxyglutamate protein	Homo sapiens	0-11
8622946-1	1996	To study the effect of apoptosis on gene amplification, we have constructed HeLa S3 cell lines in which the expression of bcl-2 (BCL2) can be controlled by tetracycline in the growth medium.	tet	156-168	BCL2 apoptosis regulator	Homo sapiens	122-127
8622946-1	1996	To study the effect of apoptosis on gene amplification, we have constructed HeLa S3 cell lines in which the expression of bcl-2 (BCL2) can be controlled by tetracycline in the growth medium.	tet	156-168	BCL2 apoptosis regulator	Homo sapiens	129-133
8833328-2	1996	Here we demonstrate the quantitative control of the expression of the luciferase gene, dihydrofolate reductase gene, and bcl-2 gene in HeLa S3 or Chinese hamster ovary AA8 cells using the tetracycline-controlled gene expression system.	tet	188-200	BCL2 apoptosis regulator	Homo sapiens	121-126
8641787-6	1996	This protection correlates with tetracycline"s ability to reduce LPS-induced TNF-alpha levels in serum.	tet	32-44	tumor necrosis factor	Mus musculus	77-86
8641787-7	1996	Furthermore, tetracycline was found to inhibit LPS-induced TNF-alpha and IL-1 beta secretion, but not cytokine mRNA accumulation, in human monocytes in vitro.	tet	13-25	tumor necrosis factor	Homo sapiens	59-68
8641787-7	1996	Furthermore, tetracycline was found to inhibit LPS-induced TNF-alpha and IL-1 beta secretion, but not cytokine mRNA accumulation, in human monocytes in vitro.	tet	13-25	interleukin 1 beta	Homo sapiens	73-82
8622649-4	1996	By presenting the results of the generation of cell lines with tetracycline-controlled expression of E2F-1 and E2F-4 and microinjection of expression plasmids for all members of the E2F family, we demonstrate here that the pRB-associated ED2Fs (E2F-1, E2F-2, and E2F-3) all induce S phase in quiescent rate fibroblasts when expressed alone.	tet	63-75	E2F transcription factor 1	Homo sapiens	101-116
8622649-4	1996	By presenting the results of the generation of cell lines with tetracycline-controlled expression of E2F-1 and E2F-4 and microinjection of expression plasmids for all members of the E2F family, we demonstrate here that the pRB-associated ED2Fs (E2F-1, E2F-2, and E2F-3) all induce S phase in quiescent rate fibroblasts when expressed alone.	tet	63-75	RB transcriptional corepressor 1	Homo sapiens	223-226
8622649-4	1996	By presenting the results of the generation of cell lines with tetracycline-controlled expression of E2F-1 and E2F-4 and microinjection of expression plasmids for all members of the E2F family, we demonstrate here that the pRB-associated ED2Fs (E2F-1, E2F-2, and E2F-3) all induce S phase in quiescent rate fibroblasts when expressed alone.	tet	63-75	E2F transcription factor 1	Homo sapiens	101-106
8622649-4	1996	By presenting the results of the generation of cell lines with tetracycline-controlled expression of E2F-1 and E2F-4 and microinjection of expression plasmids for all members of the E2F family, we demonstrate here that the pRB-associated ED2Fs (E2F-1, E2F-2, and E2F-3) all induce S phase in quiescent rate fibroblasts when expressed alone.	tet	63-75	E2F transcription factor 2	Homo sapiens	252-257
8622649-4	1996	By presenting the results of the generation of cell lines with tetracycline-controlled expression of E2F-1 and E2F-4 and microinjection of expression plasmids for all members of the E2F family, we demonstrate here that the pRB-associated ED2Fs (E2F-1, E2F-2, and E2F-3) all induce S phase in quiescent rate fibroblasts when expressed alone.	tet	63-75	E2F transcription factor 3	Homo sapiens	263-268
8643664-3	1996	Two days after the addition of tetracycline, the HC2S2 cells stopped proliferating, began to extend neurites, and expressed the neuronal markers tau, NeuN, neurofilament 200 kDa, and glutamic acid decarboxylase in accordance with the reduced production of the v-myc oncoprotein.	tet	31-43	RNA binding fox-1 homolog 3	Rattus norvegicus	150-154
8619830-3	1996	In this study, the effect of wild-type Tsc2 gene expression in Eker RC cells was tested using a tetracycline-responsive promoter system.	tet	96-108	TSC complex subunit 2	Rattus norvegicus	39-43
7585531-3	1995	We have constructed a HeLa S3 cell line in which the expression of bcl-2 can be controlled by the concentration of tetracycline in the medium.	tet	115-127	BCL2 apoptosis regulator	Homo sapiens	67-72
8869638-2	1995	CamR and TetR bind to DNA using a multihelical DNA binding domain (DBD) at the N-termini of the proteins, while the C-termini are important for regulating the DNA binding in a manner dependent on their co-factors (camphor for CamR, tetracycline for TetR).	tet	232-244	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	0-4
8869638-2	1995	CamR and TetR bind to DNA using a multihelical DNA binding domain (DBD) at the N-termini of the proteins, while the C-termini are important for regulating the DNA binding in a manner dependent on their co-factors (camphor for CamR, tetracycline for TetR).	tet	232-244	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	226-230
7557387-3	1995	Conditional ectopic expression of C/EBP beta was accomplished by using an artificial transcriptional regulatory system based on the Escherichia coli tetracycline repressor to generate a stable cell line, beta 2, that expresses C/EBP beta mRNA and protein in a tightly controlled tetracycline dose-dependent manner.	tet	149-161	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	34-44
8821036-4	1995	Plasmids encoding a tetracycline-controlled transactivator and a tetracycline-responsive connexin32 target gene were introduced in the communication-deficient SKHep1 cell line.	tet	65-77	gap junction protein beta 1	Homo sapiens	89-99
8821036-5	1995	Quantitative immunoblotting and confocal immunofluorescence microscopy with connexin32-specific antibodies demonstrated that expression of connexin32 in stable transfectants was tightly regulated by tetracycline treatment.	tet	199-211	gap junction protein beta 1	Homo sapiens	76-86
8821036-5	1995	Quantitative immunoblotting and confocal immunofluorescence microscopy with connexin32-specific antibodies demonstrated that expression of connexin32 in stable transfectants was tightly regulated by tetracycline treatment.	tet	199-211	gap junction protein beta 1	Homo sapiens	139-149
7592593-4	1995	To address this issue, a screening assay was established using heterologous fusions of the bacterial tetracycline repressor to several members of the peroxisome proliferator-activated receptor (PPAR) family.	tet	101-113	peroxisome proliferator activated receptor alpha	Homo sapiens	150-192
7592593-4	1995	To address this issue, a screening assay was established using heterologous fusions of the bacterial tetracycline repressor to several members of the peroxisome proliferator-activated receptor (PPAR) family.	tet	101-113	peroxisome proliferator activated receptor alpha	Homo sapiens	194-198
8579951-0	1995	The food-induced stimulation of bone resorption in the rat, assessed by the urinary [3H]-tetracycline excretion, is mediated by parathyroid hormone.	tet	89-101	parathyroid hormone	Rattus norvegicus	128-147
7557387-3	1995	Conditional ectopic expression of C/EBP beta was accomplished by using an artificial transcriptional regulatory system based on the Escherichia coli tetracycline repressor to generate a stable cell line, beta 2, that expresses C/EBP beta mRNA and protein in a tightly controlled tetracycline dose-dependent manner.	tet	279-291	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	34-44
7557387-7	1995	The number of beta 2 cells that can differentiate into adipocytes is related to the concentration of tetracycline and, therefore, the amount of the exogenous C/EBP beta protein expressed.	tet	101-113	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	158-168
7724601-2	1995	We utilized the bacterial tetracycline (Tet)-resistance operon regulatory system (tet) from Tn10 of Escherichia coli to control simian virus 40 (SV40) large tumor (T) antigen (TAg) gene expression and to generate conditionally transformed pancreatic beta cells in transgenic mice.	tet	26-38	temporal alpha-galactosidase	Mus musculus	176-179
7667317-2	1995	To study the effects of p53 without the complication of DNA damage, we used tetracycline to regulate its expression in MDAH041 human fibroblasts that lack endogenous p53.	tet	76-88	tumor protein p53	Homo sapiens	24-27
7667317-6	1995	MDAH041 cells arrested by tetracycline-regulated p53 for as long as 20 days resumed growth when the p53 level was lowered, in striking contrast to the irreversible arrest mediated by DNA damage.	tet	26-38	tumor protein p53	Homo sapiens	49-52
7667317-6	1995	MDAH041 cells arrested by tetracycline-regulated p53 for as long as 20 days resumed growth when the p53 level was lowered, in striking contrast to the irreversible arrest mediated by DNA damage.	tet	26-38	tumor protein p53	Homo sapiens	100-103
7646813-0	1995	Specificity of action of a herpes virus VP16/tetracycline-dependent trans-activator in mammalian cell cultures.	tet	45-57	host cell factor C1	Homo sapiens	40-44
7646813-1	1995	In this work, we have studied the activity of a tetracycline modulatable trans-activator (tTA) generated by fusing the DNA binding domain of the tetracycline repressor to the trans-activation domain of the Herpes simplex virus protein 16 (HSV VP16) (plasmid pUHD15-1Neo).	tet	48-60	host cell factor C1	Homo sapiens	243-247
7646813-1	1995	In this work, we have studied the activity of a tetracycline modulatable trans-activator (tTA) generated by fusing the DNA binding domain of the tetracycline repressor to the trans-activation domain of the Herpes simplex virus protein 16 (HSV VP16) (plasmid pUHD15-1Neo).	tet	145-157	host cell factor C1	Homo sapiens	243-247
7646813-8	1995	In HTC/A9 cells, the level of the chloramphenicol acetyltransferase (CAT) expression driven by the promoter of the alpha 1-glycoprotein (AGP) gene was strongly enhanced at 72-84 hr following removal of tetracycline from the growth media.	tet	202-214	orosomucoid 1	Rattus norvegicus	115-135
7646813-8	1995	In HTC/A9 cells, the level of the chloramphenicol acetyltransferase (CAT) expression driven by the promoter of the alpha 1-glycoprotein (AGP) gene was strongly enhanced at 72-84 hr following removal of tetracycline from the growth media.	tet	202-214	orosomucoid 1	Rattus norvegicus	137-140
7623829-1	1995	We have created fibroblast cell lines that express cyclin A under the control of a tetracycline-repressible promoter.	tet	83-95	cyclin A2	Homo sapiens	51-59
8553150-11	1995	The 25.2 MDa conjugative plasmid carrying the tetM resistance determinant was readily demonstrated in 11 Botswana/Namibia isolates exhibiting high-level resistance to tetracycline (MICs > or = 16 micrograms/ml).	tet	167-179	TetM	Neisseria gonorrhoeae	46-50
8593088-1	1995	When tetracycline and chlortetracycline were incubated an a dark room in the presence of erythrocytes with erythrocytic catalase completely inactivated by sodium azide, the antibiotics induced methemoglobin formation in them.	tet	5-17	catalase	Homo sapiens	120-128
8593088-1	1995	When tetracycline and chlortetracycline were incubated an a dark room in the presence of erythrocytes with erythrocytic catalase completely inactivated by sodium azide, the antibiotics induced methemoglobin formation in them.	tet	5-17	hemoglobin subunit gamma 2	Homo sapiens	193-206
8593088-4	1995	The effect of the methemoglobin formation on the erythrocytes was also induced by tetracycline without the catalase blocking when the erythrocytes were exposed to the antibiotic and visible light.	tet	82-94	hemoglobin subunit gamma 2	Homo sapiens	18-31
8593088-8	1995	The calorimetric estimation of the catalase functional properties showed that when exposed to visible light in the presence of the enzyme (a commercial product) tetracycline induced its inactivation.	tet	161-173	catalase	Homo sapiens	35-43
8593088-9	1995	It was indicated that the catalase photoinactivation by tetracycline was due not to a steady decrease of the activity of every molecule of the enzyme but to a dislodge of separate molecules among the active ones, i.e. a one-fold change of the enzyme molecule from the initial active state to the completely inactive one.	tet	56-68	catalase	Homo sapiens	26-34
8593088-10	1995	The catalase photoinactivation by tetracycline was not eliminated by L-histidine or comparatively high concentrations of mannitol but was entirely eliminated by ethanol used in relatively low concentrations.	tet	34-46	catalase	Homo sapiens	4-12
8593088-11	1995	When the erythrocytes were exposed to visible light in the presence of tetracycline, the effect of the catalase photoinactivation by the antibiotic was also observed.	tet	71-83	catalase	Homo sapiens	103-111
8593088-12	1995	In this case the same as in the experiments with isolated catalase, ethanol as well protected the enzyme from the photoinactivation by tetracycline.	tet	135-147	catalase	Homo sapiens	58-66
8593088-13	1995	The tetracycline photoeffects on hemoglobin, catalase and possibly other heme-containing proteins were likely realized in the immediate closeness of their hemes.	tet	4-16	catalase	Homo sapiens	45-53
7669436-4	1995	As expected, PTH (1-34) induced a significant increase of urinary pyridinoline and hydroxyproline (reflecting bone resorption), and of serum osteocalcin and alkaline phosphatase (reflecting bone formation), that were consistent with an increase of resorption and tetracycline-based formation of bone measured on iliac crest biopsy.	tet	263-275	parathyroid hormone	Homo sapiens	13-16
7737354-11	1995	Furthermore, data are presented indicating that the human beta-actin promoter should be suitable for stable expression of conditional transactivators, such as the tetracycline-responsive transactivator, in F9 cells before and after differentiation.	tet	163-175	POTE ankyrin domain family member F	Homo sapiens	58-68
7673750-7	1995	Among penicillin-resistant strains (PRP), co-resistance to trimethoprim, chloramphenicol and tetracycline was common.	tet	93-105	prion protein	Homo sapiens	36-39
7724601-2	1995	We utilized the bacterial tetracycline (Tet)-resistance operon regulatory system (tet) from Tn10 of Escherichia coli to control simian virus 40 (SV40) large tumor (T) antigen (TAg) gene expression and to generate conditionally transformed pancreatic beta cells in transgenic mice.	tet	40-43	temporal alpha-galactosidase	Mus musculus	176-179
19877917-9	1995	A tetracycline-sensitive promoter system for the artificial EGF gene allowed us to experimentally vary EGF secretion rates 20- to 200-fold.	tet	2-14	epidermal growth factor receptor	Homo sapiens	60-63
7721703-1	1995	The prgB gene encodes the surface protein Asc10, which mediates cell aggregation resulting in high-frequency conjugative transfer of the pheromone-inducible tetracycline resistance plasmid pCF10 in Enterococcus faecalis.	tet	157-169	PrgB	Enterococcus faecalis	4-8
7891684-2	1995	By fusing the KRAB domain of human Kox1 to the Tet repressor derived from Tn10 of Escherichia coli, a tetracycline-controlled hybrid protein (TetR-KRAB) was generated and constitutively expressed in HeLa cells.	tet	102-114	zinc finger protein 10	Homo sapiens	35-39
19877917-9	1995	A tetracycline-sensitive promoter system for the artificial EGF gene allowed us to experimentally vary EGF secretion rates 20- to 200-fold.	tet	2-14	epidermal growth factor receptor	Homo sapiens	103-106
7842213-8	1995	Pathologic analysis at 14 d demonstrated that the number of pleural adhesions in the heparin (8.4 +/- 3.4, mean +/- standard error) and uPA groups (6.1 +/- 2.5) was less than in saline-treated tetracycline controls (20.7 +/- 4.7) (both p < 0.02).	tet	193-205	urokinase-type plasminogen activator	Oryctolagus cuniculus	136-139
7842213-10	1995	We conclude that intrapleural heparin or uPA are equally effective in decreasing intrapleural adhesions in tetracycline-induced pleural injury.	tet	107-119	urokinase-type plasminogen activator	Oryctolagus cuniculus	41-44
7989599-2	1994	To develop a system in which the spatial and temporal expression of candidate genes implicated in cardiac development or function could be tightly controlled in vivo, we have generated transgenic mice expressing a tetracycline-controlled transactivator (tTA) under the control of a rat alpha myosin heavy chain promoter (MHC alpha-tTA mice), as well as mice harboring a candidate target gene implicated in the control of differentiation, Id1 (tet-Id1 mice).	tet	214-226	inhibitor of DNA binding 1, HLH protein	Mus musculus	447-450
22358638-8	1995	Both systems allow to control gradually the growth of mammalian cell lines by adjusting the intracellular concentration of IRF-1 via estradiol or tetracycline in the medium.	tet	146-158	interferon regulatory factor 1	Homo sapiens	123-128
7545961-0	1994	The prgQ gene of the Enterococcus faecalis tetracycline resistance plasmid pCF10 encodes a peptide inhibitor, iCF10.	tet	43-55	PrgQ	Enterococcus faecalis	4-8
7989599-2	1994	To develop a system in which the spatial and temporal expression of candidate genes implicated in cardiac development or function could be tightly controlled in vivo, we have generated transgenic mice expressing a tetracycline-controlled transactivator (tTA) under the control of a rat alpha myosin heavy chain promoter (MHC alpha-tTA mice), as well as mice harboring a candidate target gene implicated in the control of differentiation, Id1 (tet-Id1 mice).	tet	214-226	inhibitor of DNA binding 1, HLH protein	Mus musculus	438-441
7969153-3	1994	To further understand the roles of E2F in the cell cycle progression, we have overexpressed exogenous E2F-1 by using a tetracycline-controlled expression system.	tet	119-131	E2F transcription factor 1 L homeolog	Xenopus laevis	102-107
7938006-2	1994	Using a tetracycline-regulated p53 expression system and cDNA library subtraction procedure, we identified several p53-induced gene transcripts in human Saos-2 osteosarcoma cells that are novel on the basis of their size, regulation, and low abundance.	tet	8-20	tumor protein p53	Homo sapiens	31-34
7938006-2	1994	Using a tetracycline-regulated p53 expression system and cDNA library subtraction procedure, we identified several p53-induced gene transcripts in human Saos-2 osteosarcoma cells that are novel on the basis of their size, regulation, and low abundance.	tet	8-20	tumor protein p53	Homo sapiens	115-118
7926842-0	1994	A novel Tn10 tetracycline regulon system controlling expression of the bacteriophage T3 gene encoding S-adenosyl-L-methionine hydrolase.	tet	13-25	S-adenosyl-L-methionine hydrolase	Enterobacteria phage T3	102-135
7923879-8	1994	The in vivo inhibition of collagenase (MMP-8) activity during long-term doxycycline therapy in human saliva containing inflammatory exudate of ReA patients may contribute to the reduced tissue destruction observed in recent clinical and animal model studies in arthritides during long-term doxycycline/tetracycline treatment.	tet	302-314	matrix metallopeptidase 8	Homo sapiens	39-44
8000528-3	1994	In two plasmids mupA and IS257 have been duplicated and in one of these plasmids (pJ3358) a small pT181-like plasmid conferring tetracycline resistance is present flanked by copies of IS257.	tet	128-140	IS257 transposase	Staphylococcus aureus	184-189
8000528-4	1994	Filter mating with a strain containing pJ3358 as donor and selection on tetracycline sometimes resulted in transfer of the pT181-like plasmid containing a copy of IS257.	tet	72-84	IS257 transposase	Staphylococcus aureus	163-168
7531056-2	1994	Here, we tested the role of p53 in the angiogenic process by introducing a tetracycline-regulated wild type p53 gene into null glioblastoma cells.	tet	75-87	tumor protein p53	Homo sapiens	28-31
7531056-2	1994	Here, we tested the role of p53 in the angiogenic process by introducing a tetracycline-regulated wild type p53 gene into null glioblastoma cells.	tet	75-87	tumor protein p53	Homo sapiens	108-111
7996716-10	1994	As results, a good relationship was obtained except the results of tetracycline and ofloxacin for beta-lactamase non-producing H. influenzae, and ceftizoxime for E. coli, and K. pneumoniae.	tet	67-79	beta-lactamase TEM-1	Haemophilus influenzae	98-112
7978787-1	1994	The mechanism of tetracycline-induced inhibition of matrix metalloproteinases (MMP) was studied by measuring the MMP secretion and MMP-2 mRNA levels in unkeratinizing periodontal ligament epithelial cells and skin keratinocytes cultured in the presence of doxycycline or chemically modified tetracyclines (CMT) lacking antimicrobial activity.	tet	17-29	matrix metallopeptidase 2	Homo sapiens	131-136
7978787-6	1994	Tetracycline effects on the MMP-2 mRNA levels were studied in human skin keratinocytes using Northern hybridization analysis with a specific cDNA probe.	tet	0-12	matrix metallopeptidase 2	Homo sapiens	28-33
7913602-0	1994	Tetracycline/H+ antiporter was degraded rapidly in Escherichia coli cells when truncated at last transmembrane helix and this degradation was protected by overproduced GroEL/ES.	tet	0-12	GroEL	Escherichia coli	168-173
7763898-4	1993	Therefore, BST-1 is resistant to ampicillin and tetracycline, while BST-1C is resistant only to tetracycline.	tet	48-60	bone marrow stromal cell antigen 1	Mus musculus	11-16
8108147-0	1994	Inducible acceleration of G1 progression through tetracycline-regulated expression of human cyclin E. Cyclin E is a cell cycle-regulated protein that activates the cdc2-related protein kinases cdk2 shortly before S-phase entry.	tet	49-61	cyclin dependent kinase 2	Homo sapiens	193-197
8106324-13	1994	We also constructed a site-specific pvdA mutant by insertion of a tetracycline-resistance cassette in the chromosomal pvdA gene of P. aeruginosa PAO1.	tet	66-78	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	36-40
8106324-13	1994	We also constructed a site-specific pvdA mutant by insertion of a tetracycline-resistance cassette in the chromosomal pvdA gene of P. aeruginosa PAO1.	tet	66-78	L-ornithine N5-oxygenase	Pseudomonas aeruginosa PAO1	118-122
7840702-8	1994	One of them (chelating) provided the tetracycline binding to Mg2+ and Ca2+ e.g. in ribosomes and the other (toxic) affected the surrounding biological structures by the radical formation.	tet	37-49	mucin 7, secreted	Homo sapiens	61-64
8114703-1	1994	Conditional overexpression of human cyclins B1, D1, and E was accomplished by using a synthetic cDNA expression system based on the Escherichia coli tetracycline repressor.	tet	149-161	leiomodin 1	Homo sapiens	36-50
8170402-0	1994	The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.	tet	199-211	tetB(P)	Clostridium perfringens	135-142
8170402-6	1994	The tetB(P) gene would encode a putative 652 amino acid protein (molecular weight 72,639) with significant sequence similarity to Tet(M)-like cytoplasmic proteins that specify a ribosomal-protection tetracycline-resistance mechanism.	tet	199-211	tetB(P)	Clostridium perfringens	4-11
8170402-7	1994	In both C. perfringens and Escherichia coli, tetB(P) encoded low-level resistance to tetracycline and minocycline whereas tetA(P) only conferred tetracycline resistance.	tet	85-97	tetB(P)	Clostridium perfringens	45-52
8170402-8	1994	The tetA(P) and tetB(P) genes appeared to be linked in an operon, which represented a novel genetic arrangement for tetracycline-resistance determinants.	tet	116-128	tetB(P)	Clostridium perfringens	16-23
8171122-1	1994	Four copies of the insertion sequence IS257 are found in the mec region of the chromosome of the Australian methicillin resistant Staphylococcus aureus (MRSA) strain ANS46, two flanking a merAmerB sequence (encoding resistance to mercurial compounds), the other two flanking an integrated copy of the plasmid pT181 (tetracycline resistance).	tet	316-328	IS257 transposase	Staphylococcus aureus	38-43
8109938-0	1993	A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.	tet	6-18	TetH	Pasteurella multocida	43-48
8109938-0	1993	A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.	tet	105-117	TetH	Pasteurella multocida	43-48
8284502-4	1993	The beta-lactamase from the E coli had an iso-electric point (pI) of 5.4 and was encoded on a plasmid of 95 Kbp which also mediated resistance to tetracycline, sulphonamides, apramycin, streptomycin and gentamicin.	tet	146-158	kinesin family binding protein	Bos taurus	108-111
7763898-8	1993	Even with antibiotic selective pressure applied (tetracycline in the water), BST-1 did not persist as well as the non-plasmid carrying parental stain, BST-1C.	tet	49-61	bone marrow stromal cell antigen 1	Mus musculus	77-82
8503562-0	1993	Changes in cell population and tumor necrosis factor, interleukin-6, and interleukin-8 in malignant pleural effusions after treatment with intrapleural tetracycline.	tet	152-164	tumor necrosis factor	Homo sapiens	31-52
8503562-0	1993	Changes in cell population and tumor necrosis factor, interleukin-6, and interleukin-8 in malignant pleural effusions after treatment with intrapleural tetracycline.	tet	152-164	interleukin 6	Homo sapiens	54-67
8503562-0	1993	Changes in cell population and tumor necrosis factor, interleukin-6, and interleukin-8 in malignant pleural effusions after treatment with intrapleural tetracycline.	tet	152-164	C-X-C motif chemokine ligand 8	Homo sapiens	73-86
8503562-7	1993	IL-6, IL-8, and TNF were markedly increased on Day 4 after TC intrapleural injection and then decreased to baseline levels on Day 14.	tet	59-61	interleukin 6	Homo sapiens	0-4
8503562-7	1993	IL-6, IL-8, and TNF were markedly increased on Day 4 after TC intrapleural injection and then decreased to baseline levels on Day 14.	tet	59-61	tumor necrosis factor	Homo sapiens	16-19
8503562-8	1993	The results suggest that TC intrapleural injection induces the release of cytokines (IL-6 and TNF), which are markers of an inflammatory response, and releases IL-8, which attracts neutrophils into the pleural space, which may be the mechanism of the sclerosing effect of TC.	tet	25-27	interleukin 6	Homo sapiens	85-97
8503562-8	1993	The results suggest that TC intrapleural injection induces the release of cytokines (IL-6 and TNF), which are markers of an inflammatory response, and releases IL-8, which attracts neutrophils into the pleural space, which may be the mechanism of the sclerosing effect of TC.	tet	25-27	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
8268424-2	1993	Preincubation with minocycline (1 mg/l) or a chemically modified tetracycline, 4-dedimethyl-aminotetracycline (CMT-1) (1 or 10 mg/l), resulted in a significant attenuation of the magnitude of the cytosolic [Ca2+] response to an application of 5 mM-[Ni2+].	tet	65-77	myelin protein zero	Homo sapiens	111-116
8268425-1	1993	We report the effects of the tetracycline analogues 4-dedimethylaminotetracycline (CMT-1) and minocycline on osteoclast spreading and motility.	tet	29-41	myelin protein zero	Homo sapiens	83-88
8268425-3	1993	At the concentrations employed, the tetracycline-induced R effects were significantly slower than, but were qualitatively similar to, those resulting from Ca2+ "receptor" activation through the application of 15 mM-[Ca2+] (slopes: -1.25, -0.18, and -4.40/minute for 10 mg/l-[CMT-1], 10 mg/l-[minocycline] and 15 mM-[Ca2+], respectively).	tet	36-48	myelin protein zero	Homo sapiens	275-280
8363875-5	1993	These ALP+ flat cells were in contact with sites of active osteoid and mineral deposition and also codistributed with tetracycline labels outside of, and in continuity with, osteoid seams.	tet	118-130	alkaline phosphatase, placental	Homo sapiens	6-9
8093660-0	1993	Resistance to tetracycline, a hydrophilic antibiotic, is mediated by P-glycoprotein in human multidrug-resistant cells.	tet	14-26	ATP binding cassette subfamily B member 1	Homo sapiens	69-83
8093660-5	1993	Although drugs associated with the multidrug-resistance phenotype are typically hydrophobic compounds, these data suggest that resistance to tetracycline, despite its hydrophilic nature, is mediated by P-glycoprotein in these cell lines.	tet	141-153	ATP binding cassette subfamily B member 1	Homo sapiens	202-216
1508201-1	1992	We investigated the use of the prokaryotic tetracycline operator-repressor system as a regulatory device to control the expression of Dictyostelium discoideum tRNA genes.	tet	43-55	trnQ	Dictyostelium discoideum	159-163
1508201-5	1992	Addition of tetracycline (30 micrograms/ml) to the growth medium prevented repressor binding, allowed expression of the suppressor tRNA, and resulted in beta-galactosidase synthesis.	tet	12-24	trnQ	Dictyostelium discoideum	131-135
1338314-7	1992	Self-transfer and other activities of the Tcr/TcrEmr elements are regulated by tetracycline.	tet	79-91	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	42-45
1384040-1	1992	The prgB gene encodes the surface protein, Asc10, which mediates cell aggregation, resulting in high-frequency conjugative transfer of the pheromone-inducible tetracycline-resistance plasmid pCF10 in Enterococcus faecalis.	tet	159-171	PrgB	Enterococcus faecalis	4-8
1308032-0	1992	Tetracycline resistant El Tor Vibrios in Loni area.	tet	0-12	RAR related orphan receptor C	Homo sapiens	26-29
24201588-5	1992	The induction of GUS activity in the bacteria can be inhibited by chloramphenicol, tetracycline, ticarcillin and sodium azide.	tet	83-95	glucuronidase beta	Homo sapiens	17-20
1303802-2	1992	After treatment of transgenic plants with tetracycline (Tc) the activity of the reporter enzyme beta-glucuronidase (GUS) increased up to 500-fold in tissue culture as well as under greenhouse conditions.	tet	56-58	glucuronidase beta	Homo sapiens	116-119
1635920-4	1992	It has been established that 30% Eudragit L ensures a gradual uniform release of tetracycline hydrochloride (KOr = 11%/h) irrespective of variations in the pH of the gastrointestinal tract.	tet	81-107	opioid receptor kappa 1	Homo sapiens	109-112
1303802-2	1992	After treatment of transgenic plants with tetracycline (Tc) the activity of the reporter enzyme beta-glucuronidase (GUS) increased up to 500-fold in tissue culture as well as under greenhouse conditions.	tet	42-54	glucuronidase beta	Homo sapiens	96-114
1303802-2	1992	After treatment of transgenic plants with tetracycline (Tc) the activity of the reporter enzyme beta-glucuronidase (GUS) increased up to 500-fold in tissue culture as well as under greenhouse conditions.	tet	42-54	glucuronidase beta	Homo sapiens	116-119
1303802-2	1992	After treatment of transgenic plants with tetracycline (Tc) the activity of the reporter enzyme beta-glucuronidase (GUS) increased up to 500-fold in tissue culture as well as under greenhouse conditions.	tet	56-58	glucuronidase beta	Homo sapiens	96-114
1521866-1	1992	The antimicrobials tetracycline, ampicillin and bactrim (cotrimoxazole) decreased HMG CoA reductase activity in liver and small intestines of albino rats.	tet	19-31	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	82-99
1917401-7	1991	The authors tested this hypothesis by examining the differential effect of tetracycline on growth and lipase production in a tetracycline-resistant and tetracycline-sensitive strain of Staphylococcus epidermidis and S. aureus isolated from patients with MKC and Staphylococcal blepharitis.	tet	125-137	lipase	Staphylococcus aureus	102-108
1315898-4	1992	The NMR data revealed that the spin label is attached to the C-2 amide group on ring A of tetracycline.	tet	90-102	complement C2	Homo sapiens	61-64
1917401-7	1991	The authors tested this hypothesis by examining the differential effect of tetracycline on growth and lipase production in a tetracycline-resistant and tetracycline-sensitive strain of Staphylococcus epidermidis and S. aureus isolated from patients with MKC and Staphylococcal blepharitis.	tet	125-137	lipase	Staphylococcus aureus	102-108
1917401-8	1991	Tetracycline caused significant decreases in the production of lipase in the sensitive and resistant strains of S. epidermidis without concominant decreases in growth.	tet	0-12	lipase	Staphylococcus aureus	63-69
1917401-10	1991	The authors propose that the sensitivity of lipase production to tetracycline, in tetracycline-resistant S. epidermidis, may partially explain the clinical improvement observed in MKC patients.	tet	65-77	lipase	Staphylococcus aureus	44-50
1917401-10	1991	The authors propose that the sensitivity of lipase production to tetracycline, in tetracycline-resistant S. epidermidis, may partially explain the clinical improvement observed in MKC patients.	tet	82-94	lipase	Staphylococcus aureus	44-50
2066343-1	1991	Both domains, alpha and beta, of the cytoplasmic membrane-localized Tet proteins encoded by the tet gene family (classes A through E) are required for resistance to tetracycline (Tcr) in gram-negative bacteria.	tet	165-177	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	179-182
2019363-5	1991	Antimicrobial therapy (bismuth, tetracycline, and metronidazole) to eradicate the H. pylori infection was associated with a significant reduction in bombesin-stimulated gastrin release in patients with duodenal ulcer (from 116.9 +/- 19 pg/mL to 69.5 +/- 7 pg/mL following 50 pmol.kg-1.h-1 bombesin; and from 158 +/- 29 to 83.4 +/- 10 following 200 pmol.kg-1.h-1 bombesin: P = 0.01 for each).	tet	32-44	gastrin releasing peptide	Homo sapiens	149-157
2019363-5	1991	Antimicrobial therapy (bismuth, tetracycline, and metronidazole) to eradicate the H. pylori infection was associated with a significant reduction in bombesin-stimulated gastrin release in patients with duodenal ulcer (from 116.9 +/- 19 pg/mL to 69.5 +/- 7 pg/mL following 50 pmol.kg-1.h-1 bombesin; and from 158 +/- 29 to 83.4 +/- 10 following 200 pmol.kg-1.h-1 bombesin: P = 0.01 for each).	tet	32-44	gastrin	Homo sapiens	169-176
1854161-1	1991	The tetracycline (Tet) determinants, which encode resistance either to tetracyclines without minocycline (Tcr) or to tetracyclines including minocycline (Tcr-Mnr), of 30 wild-type clinical isolates of Enterococcus faecium were identified and localized.	tet	4-16	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	106-109
1854161-1	1991	The tetracycline (Tet) determinants, which encode resistance either to tetracyclines without minocycline (Tcr) or to tetracyclines including minocycline (Tcr-Mnr), of 30 wild-type clinical isolates of Enterococcus faecium were identified and localized.	tet	4-16	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	154-157
1854161-1	1991	The tetracycline (Tet) determinants, which encode resistance either to tetracyclines without minocycline (Tcr) or to tetracyclines including minocycline (Tcr-Mnr), of 30 wild-type clinical isolates of Enterococcus faecium were identified and localized.	tet	18-21	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	106-109
1854161-1	1991	The tetracycline (Tet) determinants, which encode resistance either to tetracyclines without minocycline (Tcr) or to tetracyclines including minocycline (Tcr-Mnr), of 30 wild-type clinical isolates of Enterococcus faecium were identified and localized.	tet	18-21	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	154-157
1854161-2	1991	The Tet determinants were transferred by conjugation into a plasmid-free Enterococcus faecalis recipient at frequencies of 10(-6) to 10(-9) transconjugants per donor, as follows: Tcr, 6 strains; Tcr-Mnr, 14 strains; both Tcr and Tcr-Mnr, 6 strains; no detectable transfer, 4 strains.	tet	4-7	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	179-182
1854161-3	1991	Classes L (Tcr phenotype) and M and O (Tcr-Mnr phenotype) of the Tet determinants were identified by DNA-DNA hybridization experiments.	tet	65-68	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	11-14
1854161-3	1991	Classes L (Tcr phenotype) and M and O (Tcr-Mnr phenotype) of the Tet determinants were identified by DNA-DNA hybridization experiments.	tet	65-68	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	39-42
24193980-6	1990	The addition of catalase to plate count agar containing nalidixic acid and tetracycline negated the effect caused by this combination of antibiotics.	tet	75-87	catalase	Homo sapiens	16-24
2089219-0	1990	Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins.	tet	97-109	QacA	Staphylococcus aureus	43-47
2089219-4	1990	The putative polypeptide specified by qacA has properties typical of a cytoplasmic membrane protein, and is indicated to be a member of a transport protein family that includes proteins responsible for export-mediated resistance to tetracycline and methylenomycin, and uptake of sugars and quinate.	tet	232-244	QacA	Staphylococcus aureus	38-42
2089219-6	1990	The last common ancestor of the qacA and related tet (tetracycline resistance) lineages is inferred to have been repressor controlled, as occurs for modern tet determinants from Gram-negative, but not those from Gram-positive, bacteria.	tet	54-66	QacA	Staphylococcus aureus	32-36
2281827-5	1990	The increase in cancellous bone induced by PTH was associated with an over 70% increase in osteoblasts and tetracycline-labeled area and an unexpected decrease in trabecular osteoclasts.	tet	107-119	parathyroid hormone	Rattus norvegicus	43-46
2388142-9	1990	Tetracycline and tetracycline with fibronectin groups demonstrated some reattachment, but only within the notches placed in the root at the original level of the bone.	tet	17-29	fibronectin 1	Homo sapiens	35-46
1698759-1	1990	The capacity of minocycline and tetracycline for modulation of IL-1 secretion by LPS-stimulated human monocytes was investigated in vitro.	tet	32-44	interleukin 1 beta	Homo sapiens	63-67
1698759-2	1990	Both minocycline and tetracycline suppressed the murine thymocyte co-mitogenic bioassay of IL-1 at 2 and 4 mg/l respectively.	tet	21-33	interleukin 1 complex	Mus musculus	91-95
1698759-8	1990	Although tetracycline enhanced IL-1 beta secretion in four of the five replicate experiments, this did not prove significant owing to the large error variance between individual monocyte cultures.	tet	9-21	interleukin 1 beta	Mus musculus	31-40
2388142-11	1990	The additional application of fibronectin to tetracycline treated roots appeared to partially negate the enhanced connective tissue attachment observed with tetracycline treatment alone.	tet	45-57	fibronectin 1	Homo sapiens	30-41
2388142-11	1990	The additional application of fibronectin to tetracycline treated roots appeared to partially negate the enhanced connective tissue attachment observed with tetracycline treatment alone.	tet	157-169	fibronectin 1	Homo sapiens	30-41
33773789-12	2021	The genes tetA, sul2, and floR were the most frequently observed AMR genes in K. pneumoniae resistant to tetracycline, sulfamethoxazole-trimethoprim, and chloramphenicol, respectively.	tet	105-117	Florfenicol/Chloramphenicol efflux protein	Klebsiella pneumoniae	26-30
2185211-1	1990	Inner membrane Tet proteins encoded by tet genes in gram-negative bacteria mediate resistance to tetracycline (Tcr) by directing its export.	tet	97-109	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	111-114
2151783-0	1990	Effect of tetracycline on lymphocyte antigen expression.	tet	10-22	major histocompatibility complex, class II, DO alpha	Homo sapiens	26-44
2305876-3	1990	Histomorphometric analysis of caudal vertebrae showed that EGF (20 and 200 ng.g-1.day-1) reduced the endosteal matrix and mineral appositional rates after 5 days of treatment as measured by double [3H]proline labeling and double tetracycline labeling, respectively.	tet	229-241	epidermal growth factor	Mus musculus	59-62
2305876-5	1990	EGF administered for 7 days induced a dose-dependent increase in the periosteal osteoblastic and tetracycline double-labeled surfaces.	tet	97-109	epidermal growth factor	Mus musculus	0-3
2320784-2	1990	The aim of this study was to assess the value of peridural thoracic analgesia (ATP) to prevent pain observed during pleural symphysis with tetracycline (STP) for pneumothorax (PNO).	tet	139-151	thyroid hormone receptor interactor 10	Homo sapiens	153-156
33970999-4	2021	Here, we show that overexpression of IL-7Ralpha in tetracycline-inducible Il7r transgenic and Rosa26 IL7R knock-in mice drives potential thymocyte self-renewal, and thymus hyperplasia due to increased proliferation of T-cell precursors, which subsequently infiltrate lymph nodes, spleen and bone marrow, ultimately leading to fatal leukemia.	tet	51-63	interleukin 7 receptor	Mus musculus	37-47
33970999-4	2021	Here, we show that overexpression of IL-7Ralpha in tetracycline-inducible Il7r transgenic and Rosa26 IL7R knock-in mice drives potential thymocyte self-renewal, and thymus hyperplasia due to increased proliferation of T-cell precursors, which subsequently infiltrate lymph nodes, spleen and bone marrow, ultimately leading to fatal leukemia.	tet	51-63	interleukin 7 receptor	Mus musculus	74-78
34871595-8	2022	Moreover, it was found that a typical bacterial persister originated from Acinetobacter, named T9-9, could tolerate a variety of antibiotics, such as 1000 mug/mL of kanamycin, 160 mug/mL of tetracycline, and 30 mug/mL of ciprofloxacin.	tet	190-202	transferrin receptor	Homo sapiens	95-99
33760701-10	2021	In experimental ALI, tetracycline significantly diminished lung injury and pulmonary inflammation by selectively inhibiting caspase-1-dependent IL-1beta and IL-18 production leading to improved survival.	tet	21-33	caspase 1	Homo sapiens	124-133
33760701-10	2021	In experimental ALI, tetracycline significantly diminished lung injury and pulmonary inflammation by selectively inhibiting caspase-1-dependent IL-1beta and IL-18 production leading to improved survival.	tet	21-33	interleukin 1 alpha	Homo sapiens	144-152
33760701-10	2021	In experimental ALI, tetracycline significantly diminished lung injury and pulmonary inflammation by selectively inhibiting caspase-1-dependent IL-1beta and IL-18 production leading to improved survival.	tet	21-33	interleukin 18	Homo sapiens	157-162
33760701-11	2021	Tetracycline also reduced the production of IL-1beta and IL-18 by alveolar leucocytes from patients with direct ARDS.	tet	0-12	interleukin 1 alpha	Homo sapiens	44-52
33760701-11	2021	Tetracycline also reduced the production of IL-1beta and IL-18 by alveolar leucocytes from patients with direct ARDS.	tet	0-12	interleukin 18	Homo sapiens	57-62
33760701-12	2021	CONCLUSIONS: Tetracycline may be effective in the treatment of direct ARDS in patients with elevated caspase-1 activity.	tet	13-25	caspase 1	Homo sapiens	101-110
25895579-3	2015	Here we characterized a Sox10(rtTA/+) knock-in mouse line which demonstrates inducible reverse tetracycline trans-activator (rtTA) activity and Tet-On transgene expression in the inner ear following induction with the tetracycline derivative doxycycline (Dox).	tet	95-107	SRY (sex determining region Y)-box 10	Mus musculus	24-29
33760701-0	2021	Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury.	tet	29-41	caspase 1	Homo sapiens	14-23
33760701-4	2021	Recent studies indicate that tetracycline can be used to treat inflammatory diseases mediated by IL-1beta and IL-18 while the molecular mechanism by which tetracycline inhibits inflammasome-caspase-1 signaling remains unknown.	tet	29-41	interleukin 1 alpha	Homo sapiens	97-105
33760701-4	2021	Recent studies indicate that tetracycline can be used to treat inflammatory diseases mediated by IL-1beta and IL-18 while the molecular mechanism by which tetracycline inhibits inflammasome-caspase-1 signaling remains unknown.	tet	29-41	interleukin 18	Homo sapiens	110-115
33760701-4	2021	Recent studies indicate that tetracycline can be used to treat inflammatory diseases mediated by IL-1beta and IL-18 while the molecular mechanism by which tetracycline inhibits inflammasome-caspase-1 signaling remains unknown.	tet	155-167	caspase 1	Homo sapiens	190-199
33760701-5	2021	OBJECTIVES: To identify patients with ARDS characterized by IL-1beta and IL-18 expression and investigate the ability of tetracycline to inhibit inflammasome-caspase-1 signaling in ARDS.	tet	121-133	caspase 1	Homo sapiens	158-167
33760701-7	2021	Tetracycline"s effect on lung injury and inflammation were assessed in two mouse models of direct (pulmonary) acute lung injury (ALI) and on IL-1beta and IL-18 production by alveolar leucocytes from patients with direct ARDS ex vivo.	tet	0-12	interleukin 1 alpha	Mus musculus	141-149
33760701-8	2021	Murine macrophages were used to further characterize the effect of tetracycline on the inflammasome-caspase-1 pathway.	tet	67-79	caspase 1	Mus musculus	100-109
17502371-8	2007	To address this, we used a tetracycline-inducible HAS3 expression system in which hyaluronan production could be experimentally controlled.	tet	27-39	hyaluronan synthase 3	Homo sapiens	50-54
17522335-7	2007	beta-Gal activity in J3T cells was also higher with the mCMV than the hCMV promoter driving tetracycline-dependent (TetON) transgene expression within high-capacity adenovirus vectors (HC-Ads).	tet	92-104	galactosidase, beta 1	Mus musculus	0-8
34772565-7	2022	Under optimal conditions, the linear detection range of tetracycline was 0.5-1000 ng mL-1, and the detection limit was 0.17 ng mL-1.	tet	56-68	L1 cell adhesion molecule	Mus musculus	85-89
34772565-7	2022	Under optimal conditions, the linear detection range of tetracycline was 0.5-1000 ng mL-1, and the detection limit was 0.17 ng mL-1.	tet	56-68	L1 cell adhesion molecule	Mus musculus	127-131
34774615-0	2022	Synthesis and application of CdS nanorods for LED-based photocatalytic degradation of tetracycline antibiotic.	tet	86-98	small integral membrane protein 10 like 2A	Homo sapiens	46-49
34748779-10	2022	Electro-Fenton using TRGO-1100-ABC exhibited great performance for Persistent Organic Pollutants (POPs) degradation, which removed 66% of tetracycline in 5 min.	tet	138-150	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	31-34
34891056-0	2022	Combined effect of tetracycline and copper ion on catalase activity of microorganisms during the biological phosphorus removal.	tet	19-31	catalase	Homo sapiens	50-58
34890952-0	2022	Facile fabrication of Fe/Fe3C embedded in N-doped carbon nanofiber for efficient degradation of tetracycline via peroxymonosulfate activation: Role of superoxide radical and singlet oxygen.	tet	96-108	general transcription factor IIE subunit 1	Homo sapiens	22-24
34890952-3	2022	The as-obtained Fe/Fe3C@NCNF-800 possessed a low Ea value (11.7 kJ/mol) and exhibited high activity for activating PMS to degrade tetracycline (TC) in a wide range of pH 3-11.	tet	130-142	general transcription factor IIE subunit 1	Homo sapiens	16-18
34890952-3	2022	The as-obtained Fe/Fe3C@NCNF-800 possessed a low Ea value (11.7 kJ/mol) and exhibited high activity for activating PMS to degrade tetracycline (TC) in a wide range of pH 3-11.	tet	144-146	general transcription factor IIE subunit 1	Homo sapiens	16-18
34891056-10	2022	The study of the combined effects of tetracycline and copper ion on the catalase activity is helpful to further study their ecotoxicological mechanisms in wastewater treatment.	tet	37-49	catalase	Homo sapiens	72-80
34737124-5	2022	Tetracycline also increased the abundances of As-reducing genes (arsC and arrA) and the relative abundances of As-reducing bacteria Streptomyces, Bacillus, Burkholderia, Clostridium and Rhodococcus, all of which have been found resistant to tetracycline.	tet	0-12	steroid sulfatase	Homo sapiens	65-69
34902482-3	2022	This paper describes the construction and performance of 3DE-BAF in the treatment of simulated wastewater represented by tetracycline (TC).	tet	121-133	BAF nuclear assembly factor 1	Homo sapiens	61-64
34902482-3	2022	This paper describes the construction and performance of 3DE-BAF in the treatment of simulated wastewater represented by tetracycline (TC).	tet	135-137	BAF nuclear assembly factor 1	Homo sapiens	61-64
34545522-0	2022	Effect of light on concomitant sequestration of Cu(II) and photodegradation of tetracycline by H-MOR/H-beta/H-ZSM5 zeolites.	tet	79-91	opioid receptor mu 1	Homo sapiens	97-100
34731707-3	2022	Under dark condition, the TC removal rates of NNT1/BS and NNT2/BS reached about 91.7% and 95.5% respectively at 60 min.	tet	26-28	cardiotrophin like cytokine factor 1	Homo sapiens	46-50
34592449-3	2022	Adsorption kinetic experiments showed that the Ca-MBHC could eliminate Pb(II) and TC during a wide range of pH, and appeared rapid uptake equilibrium within 240 and 60 min for Pb(II) and TC, severally.	tet	187-189	submaxillary gland androgen regulated protein 3B	Homo sapiens	71-77
34919957-0	2022	High efficiency degradation of tetracycline by peroxymonosulfate activated with Fe/NC catalysts: Performance, intermediates, stability and mechanism.	tet	31-43	general transcription factor IIE subunit 1	Homo sapiens	80-82
34919957-4	2022	In a wide pH range (1-11), the Fe/CN-30 catalyst can efficiently degrade tetracycline (TC) with a small amount of PMS.	tet	73-85	general transcription factor IIE subunit 1	Homo sapiens	31-33
34919957-4	2022	In a wide pH range (1-11), the Fe/CN-30 catalyst can efficiently degrade tetracycline (TC) with a small amount of PMS.	tet	87-89	general transcription factor IIE subunit 1	Homo sapiens	31-33
34919957-5	2022	The non-radical pathways are prominent in the TC decomposition process according to the quenching experiments, electron paramagnetic resonance (EPR) and gas chromatograph-mass spectrometer (GC-MS) analysis, in which the contribution of high-valent iron-oxo species (Fe(IV) = O) was dominant.	tet	46-48	general transcription factor IIE subunit 1	Homo sapiens	266-268
34919957-6	2022	X-ray photoelectron spectroscopy and reaction kinetic experiments confirmed that the coordination sites of Fe and N in the Fe/CN-30 are the reactive centers for TC degradation.	tet	161-163	general transcription factor IIE subunit 1	Homo sapiens	107-109
34919957-6	2022	X-ray photoelectron spectroscopy and reaction kinetic experiments confirmed that the coordination sites of Fe and N in the Fe/CN-30 are the reactive centers for TC degradation.	tet	161-163	general transcription factor IIE subunit 1	Homo sapiens	123-125
34919957-8	2022	Furthermore, by-products of TC degradation in the Fe/CN-30/PMS system and the possible TC degradation pathways were proposed via liquid chromatography-mass spectrometry (LC-MS).	tet	28-30	general transcription factor IIE subunit 1	Homo sapiens	50-52
34919957-8	2022	Furthermore, by-products of TC degradation in the Fe/CN-30/PMS system and the possible TC degradation pathways were proposed via liquid chromatography-mass spectrometry (LC-MS).	tet	87-89	general transcription factor IIE subunit 1	Homo sapiens	50-52
34694885-5	2022	Introducing the ramAp and the truncated ISEcp1 into E. coli have resulted in elevated expression of efflux pump genes and elevated MICs to chloramphenicol, azithromycin, nalidixic acid, ciprofloxacin, sulfamethoxazole, trimethoprim, tetracycline, and tigecycline.	tet	233-245	ISEcp1	Escherichia coli	40-46
34560942-2	2021	Copper nanoparticles immobilized-beta-cyclodextrin functionalized reduced graphene oxide (Cu/beta-CD/rGO) were successfully prepared as an efficient extractor of tetracycline (TC), oxytetracycline (OTC) and doxycycline (DC) antibiotics from different environmental water samples.	tet	162-174	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	93-100
34926920-7	2021	On the other hand, the intrinsic Co2+/Co3+ redox cycling can accelerate the circulation between Fe2+ and Fe3+ in Co(5%)-Fe2O3 spindles to facilitate H2O2 consumption and produce more  OH radicals for TC degradation.	tet	200-202	complement C2	Homo sapiens	33-36
34943759-13	2021	Among these are acquired AMR determinants including fluoroquinolone resistance-conferring genes aac(3)-Ib-cr and other significant genes: aad, tet, sul1, sul2, and cat, which are associated with aminoglycoside, tetracycline, sulfonamide, and chloramphenicol resistance, respectively.	tet	211-223	dihydropteroate synthase	Escherichia coli	148-152
34943759-13	2021	Among these are acquired AMR determinants including fluoroquinolone resistance-conferring genes aac(3)-Ib-cr and other significant genes: aad, tet, sul1, sul2, and cat, which are associated with aminoglycoside, tetracycline, sulfonamide, and chloramphenicol resistance, respectively.	tet	211-223	dihydropteroate synthase protein Sul2	Escherichia coli	154-158
34560942-2	2021	Copper nanoparticles immobilized-beta-cyclodextrin functionalized reduced graphene oxide (Cu/beta-CD/rGO) were successfully prepared as an efficient extractor of tetracycline (TC), oxytetracycline (OTC) and doxycycline (DC) antibiotics from different environmental water samples.	tet	176-178	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	93-100
34560942-6	2021	The maximum adsorption capacity (qm) of Cu/beta-CD/rGO calculated from the Langmuir isotherm was 403.2 mg.g-1 for TC, 476.2 mg.g-1 for OTC and 434.8 mg.g-1 for DC at 298 K. The removal efficiency was decreased by 3.7% after five adsorption-desorption cycles.	tet	114-116	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	43-50
34725188-4	2021	Sustained ErbB activation induced by the tetracycline-dependent mouse tool Plp-tTA resulted in demyelination, axonal degeneration, oligodendrocyte precursor cell (OPC) proliferation, astrogliosis, and microgliosis in white matter.	tet	41-53	epidermal growth factor receptor	Mus musculus	10-14
34382357-6	2021	RESULTS: We identified a site 10.5 kbps upstream from the Zxdb gene as a locus that allows homogenous transgene expression from a tetracycline responsible promoter.	tet	130-142	zinc finger, X-linked, duplicated B	Mus musculus	58-62
34379810-4	2021	Concentrations of ABs in the aquatic environment vary significantly, studies have shown fluoroquinolones, tetracycline, macrolides, sulphonamides and penicillins to reach 2900, 1500, 9700, 21400 and 1600 ngL-1 in wastewater effluent samples, however, concentrations are highly variable between different countries and depend on several factors including seasonally variation, prescription, and WWTP operating procedures.	tet	106-118	leucine rich repeat containing 4C	Homo sapiens	204-209
34725188-4	2021	Sustained ErbB activation induced by the tetracycline-dependent mouse tool Plp-tTA resulted in demyelination, axonal degeneration, oligodendrocyte precursor cell (OPC) proliferation, astrogliosis, and microgliosis in white matter.	tet	41-53	proteolipid protein (myelin) 1	Mus musculus	75-78
34725188-6	2021	In contrast, sustained ErbB activation induced by another tetracycline-dependent mouse tool Sox10 +/rtTA caused hypomyelination in the corpus callosum and optic nerve, which appeared to be a developmental deficit and did not associate with OPC regeneration, astrogliosis, or microgliosis.	tet	58-70	epidermal growth factor receptor	Mus musculus	23-27
34725188-6	2021	In contrast, sustained ErbB activation induced by another tetracycline-dependent mouse tool Sox10 +/rtTA caused hypomyelination in the corpus callosum and optic nerve, which appeared to be a developmental deficit and did not associate with OPC regeneration, astrogliosis, or microgliosis.	tet	58-70	SRY (sex determining region Y)-box 10	Mus musculus	92-97
34456193-4	2021	Methods and Results: The lentivirus system driven by tetracycline (TET)-on carrying Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, hTERT, and SV40LT (OSKMNLST) could reprogram sheep kidney cells into pluripotent cells.	tet	53-65	transcription factor SOX-2	Ovis aries	90-94
34456193-4	2021	Methods and Results: The lentivirus system driven by tetracycline (TET)-on carrying Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, hTERT, and SV40LT (OSKMNLST) could reprogram sheep kidney cells into pluripotent cells.	tet	53-65	myc proto-oncogene protein	Ovis aries	96-101
34456193-4	2021	Methods and Results: The lentivirus system driven by tetracycline (TET)-on carrying Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, hTERT, and SV40LT (OSKMNLST) could reprogram sheep kidney cells into pluripotent cells.	tet	53-65	Krueppel-like factor 4	Ovis aries	103-107
34456193-4	2021	Methods and Results: The lentivirus system driven by tetracycline (TET)-on carrying Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, hTERT, and SV40LT (OSKMNLST) could reprogram sheep kidney cells into pluripotent cells.	tet	53-65	homeobox protein NANOG	Ovis aries	109-114
34456193-4	2021	Methods and Results: The lentivirus system driven by tetracycline (TET)-on carrying Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, hTERT, and SV40LT (OSKMNLST) could reprogram sheep kidney cells into pluripotent cells.	tet	53-65	protein lin-28 homolog A	Ovis aries	116-121
34456193-4	2021	Methods and Results: The lentivirus system driven by tetracycline (TET)-on carrying Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, hTERT, and SV40LT (OSKMNLST) could reprogram sheep kidney cells into pluripotent cells.	tet	53-65	telomerase reverse transcriptase	Homo sapiens	123-128
34769495-6	2021	To examine the effects of CQ on tau metabolism, we used a human neuroblastoma cell line, M1C cells, which express wild-type tau protein (4R0N) via tetracycline-off (TetOff) induction.	tet	147-159	microtubule associated protein tau	Homo sapiens	124-127
34672196-0	2021	Programmable-Printing Paper-Based Device with a MoS2 NP and Gmp/Eu-Cit Fluorescence Couple for Ratiometric Tetracycline Analysis in Various Natural Samples.	tet	107-119	5'-nucleotidase, cytosolic II	Homo sapiens	60-63
34754016-0	2021	Tunable control of CAR T cell activity through tetracycline mediated disruption of protein-protein interaction.	tet	47-59	nuclear receptor subfamily 1 group I member 3	Homo sapiens	19-22
34754016-3	2021	These exploit the binding between the tetracycline repressor protein and a small peptide sequence (TIP) to spontaneously assemble as a functional CAR.	tet	38-50	nuclear receptor subfamily 1 group I member 3	Homo sapiens	146-149
34827354-8	2021	Fourteen S. aureus were susceptible to all antimicrobials tested and the remaining showed resistance to penicillin, erythromycin and/or tetracycline encoded by the blaZ, ermT, msr(A/B), tetL, and vgaA genes.	tet	136-148	ABC transporter permease protein	Staphylococcus aureus	176-183
34246804-3	2021	METHODS: We developed a tetracycline-on system of pre-miR-21 induction in clonal beta-cells and human islets, as well as transgenic zebrafish and mouse models of beta-cell specific pre-miR-21 overexpression.	tet	24-36	microRNA 21	Homo sapiens	54-60
34182642-5	2021	Spin-trapping electron paramagnetic resonance measurements and quenching experiments demonstrated that O2-, OH, 1O2 and h+ contributed to TCH degradation.	tet	138-141	spindlin 1	Homo sapiens	0-4
34831234-2	2021	In this study, we used a tetracycline-inducible system to control the expression of a mutant PAK3 (mPAK3) protein in immediate early gene, namely cFos, positive cells to disrupt PAK signaling, specifically in cells activated by social interaction in transgenic mice.	tet	25-37	p21 (RAC1) activated kinase 3	Mus musculus	93-97
34831234-2	2021	In this study, we used a tetracycline-inducible system to control the expression of a mutant PAK3 (mPAK3) protein in immediate early gene, namely cFos, positive cells to disrupt PAK signaling, specifically in cells activated by social interaction in transgenic mice.	tet	25-37	p21 (RAC1) activated kinase 3	Mus musculus	99-104
34831234-2	2021	In this study, we used a tetracycline-inducible system to control the expression of a mutant PAK3 (mPAK3) protein in immediate early gene, namely cFos, positive cells to disrupt PAK signaling, specifically in cells activated by social interaction in transgenic mice.	tet	25-37	FBJ osteosarcoma oncogene	Mus musculus	146-150
34831234-2	2021	In this study, we used a tetracycline-inducible system to control the expression of a mutant PAK3 (mPAK3) protein in immediate early gene, namely cFos, positive cells to disrupt PAK signaling, specifically in cells activated by social interaction in transgenic mice.	tet	25-37	p21 (RAC1) activated kinase 3	Mus musculus	178-181
34927952-3	2021	Herein, silicon quantum dots (SiQDs) are designed as a functional platform for the detection of tetracycline and Zn2+ /Cd2+ .	tet	96-108	CD2 molecule	Homo sapiens	119-122
34827252-0	2021	Presence of Tetracycline and Sulfonamide Resistance Genes in Salmonella spp.	tet	12-24	histocompatibility minor 13	Homo sapiens	72-75
34827252-8	2021	The tetracycline resistance genes most frequently detected from Salmonella spp.	tet	4-16	histocompatibility minor 13	Homo sapiens	75-78
34765293-3	2021	Stable cell lines were established using the clustered regularly interspaced short palindromic repeats (CRISPR)-associated nuclease 9 (CRISPR/Cas9)-based DKK1 knock-out system in Hep3B cells and the tetracycline-based DKK1 inducible system in Huh7 cells.	tet	199-211	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	218-222
34325101-5	2021	The ARG composition was differently impacted by rapid urbanization and dam construction, which urbanization could promote ARGs resistant to sulfonamide and tetracycline, whereas dam construction could elevate the resistance to chloramphenicol and aminoglycoside.	tet	156-168	serpin family A member 2 (gene/pseudogene)	Homo sapiens	122-126
34575457-0	2021	Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride.	tet	78-104	adenosine monophosphate deaminase 1	Homo sapiens	53-57
34575457-6	2021	In the presence of AMPD, the TC level in aqueous solution decreased drastically to ca.	tet	29-31	adenosine monophosphate deaminase 1	Homo sapiens	19-23
34570349-5	2022	To assess whether stroke outcomes could be improved by elevating astrocytic miR-20a-3p, we created a tetracycline (Tet)-induced recombinant adeno-associated virus (rAAV) construct where miR-20a-3p was located downstream a glial fibrillary acidic protein promoter.	tet	101-113	glial fibrillary acidic protein	Homo sapiens	222-253
34570349-5	2022	To assess whether stroke outcomes could be improved by elevating astrocytic miR-20a-3p, we created a tetracycline (Tet)-induced recombinant adeno-associated virus (rAAV) construct where miR-20a-3p was located downstream a glial fibrillary acidic protein promoter.	tet	115-118	glial fibrillary acidic protein	Homo sapiens	222-253
34570349-7	2022	A second Tet-induced rAAV construct was created in which miR-20a-3p was located downstream of a neuron-specific enolase (NSE) promoter.	tet	9-12	enolase 2	Homo sapiens	96-119
34280616-4	2021	In this study, we established AhR-re-expressing (KOTR-AhR) cells from AhR knockout MCF-7 cells using the tetracycline (Tet)-inducible gene expression systems.	tet	105-117	aryl hydrocarbon receptor	Homo sapiens	30-33
34280616-4	2021	In this study, we established AhR-re-expressing (KOTR-AhR) cells from AhR knockout MCF-7 cells using the tetracycline (Tet)-inducible gene expression systems.	tet	105-117	aryl hydrocarbon receptor	Homo sapiens	54-57
34280616-4	2021	In this study, we established AhR-re-expressing (KOTR-AhR) cells from AhR knockout MCF-7 cells using the tetracycline (Tet)-inducible gene expression systems.	tet	105-117	aryl hydrocarbon receptor	Homo sapiens	70-73
34280616-4	2021	In this study, we established AhR-re-expressing (KOTR-AhR) cells from AhR knockout MCF-7 cells using the tetracycline (Tet)-inducible gene expression systems.	tet	119-122	aryl hydrocarbon receptor	Homo sapiens	30-33
34280616-4	2021	In this study, we established AhR-re-expressing (KOTR-AhR) cells from AhR knockout MCF-7 cells using the tetracycline (Tet)-inducible gene expression systems.	tet	119-122	aryl hydrocarbon receptor	Homo sapiens	54-57
34280616-4	2021	In this study, we established AhR-re-expressing (KOTR-AhR) cells from AhR knockout MCF-7 cells using the tetracycline (Tet)-inducible gene expression systems.	tet	119-122	aryl hydrocarbon receptor	Homo sapiens	70-73
34440750-4	2021	Therefore, to overcome these deficiencies, we investigated whether tetracycline-inducible L-myc gene expression promotes self-renewal activity and tumorigenicity in the production of induced conditional self-renewing fibroblast cells (iCSFCs).	tet	67-79	MYCL proto-oncogene, bHLH transcription factor	Canis lupus familiaris	90-95
34440932-3	2021	COL-3"s inhibitory effects on TNF-alpha were reproduced by the tetracycline antibiotic doxycycline (DOX; 50 microM), the glucocorticoid dexamethasone, and apocynin (APO), an inhibitor of the superoxide-producing enzyme NADPH oxidase.	tet	63-75	tumor necrosis factor	Mus musculus	30-39
34440750-6	2021	We established conditionally inducible self-renewing fibroblast cells by transducing CFF-3 cells with L-myc under the tetracycline-inducible gene expression system.	tet	118-130	MYCL proto-oncogene, bHLH transcription factor	Canis lupus familiaris	102-107
34356509-2	2021	In this study, we used the stable, inducible expressions of wild-type (WT) MCPIP1 and an MCPIP1-D141N mutant in T-REx-293 cells by means of a tetracycline on (Tet-on) system.	tet	142-154	zinc finger CCCH-type containing 12A	Homo sapiens	75-81
34250990-7	2021	Under the optimal parameters, the half-inhibitory concentration (IC50) and limit of detection (LOD, IC10) of TC were 0.4188 ng mL-1 and 0.0106 ng mL-1, respectively.	tet	109-111	L1 cell adhesion molecule	Mus musculus	127-131
34250990-7	2021	Under the optimal parameters, the half-inhibitory concentration (IC50) and limit of detection (LOD, IC10) of TC were 0.4188 ng mL-1 and 0.0106 ng mL-1, respectively.	tet	109-111	L1 cell adhesion molecule	Mus musculus	146-150
34362003-3	2021	The cutaneous adverse reactions induced by EGFR inhibitors, particularly papulopustular rash, often require long-term antibiotic treatment with tetracycline agents (mostly minocycline and doxycycline).	tet	144-156	epidermal growth factor receptor	Homo sapiens	43-47
34280904-0	2021	Oxygen vacancy-rich 2D/0D BiO1-XBr/AgBr Z-scheme photocatalysts for efficient visible light driven degradation of tetracycline.	tet	114-126	RE1 silencing transcription factor	Homo sapiens	31-34
34280904-5	2021	Notably, the photocatalytic activity of 2D/0D BiO1-XBr/AgBr (2:1) was significantly improved under the irradiation of visible light, removing 81% of tetracycline after 25 minutes, which was about 2.62 times and 2.03 times as high as those of BiO1-XBr and AgBr, respectively.	tet	149-161	RE1 silencing transcription factor	Homo sapiens	51-54
34280904-6	2021	In addition, the 2D/0D BiO1-XBr/AgBr (2:1) indicated high photocatalytic stability and reusability, and its tetracycline degradation efficiency keep stable after five cycles.	tet	108-120	RE1 silencing transcription factor	Homo sapiens	28-31
34356509-2	2021	In this study, we used the stable, inducible expressions of wild-type (WT) MCPIP1 and an MCPIP1-D141N mutant in T-REx-293 cells by means of a tetracycline on (Tet-on) system.	tet	142-154	zinc finger CCCH-type containing 12A	Homo sapiens	89-95
34094619-6	2021	Ten of 21 isolates were resistant to penicillin, ciprofloxacin and tetracycline, due mainly to the presence of the blaTEM gene, the S91F mutation in the gyrA gene and the tetM gene, respectively.	tet	67-79	TetM	Neisseria gonorrhoeae	171-175
34285790-1	2021	Aims: An antibiotic combination of amoxicillin, tetracycline and metronidazole (ATM) is effective for ulcerative colitis (UC), but this regimen is discontinued in some cases due to adverse events.	tet	48-60	ATM serine/threonine kinase	Homo sapiens	80-83
34355118-6	2021	Raman spectra were measured from sEVs isolated from Alzheimer"s disease cell culture model, where secretion of Abeta is regulated by tetracycline promoter, and from midbrain organoids.	tet	133-145	amyloid beta precursor protein	Homo sapiens	111-116
34083621-0	2021	Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system.	tet	14-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	40-46
34083621-6	2021	A tetracycline-controllable CYP3A4 expression cassette (tet-on system) was stably transduced into Caco-2 cells, thus regulating the levels of CYP3A4 expression depending on the doxycycline concentration.	tet	2-14	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	28-34
34083621-6	2021	A tetracycline-controllable CYP3A4 expression cassette (tet-on system) was stably transduced into Caco-2 cells, thus regulating the levels of CYP3A4 expression depending on the doxycycline concentration.	tet	2-14	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	142-148
34084695-0	2021	Fluorescent tetracycline bone labeling as an intraoperative tool to debride necrotic bone during septic hip revision: a preliminary case series.	tet	12-24	hedgehog interacting protein	Homo sapiens	104-107
35533931-4	2022	The obtained BiOI(001)/CdS material shown the maximum degradation for tetracycline-based antibiotics (Oxytetracycline, Tetracycline and Doxycycline), and excellent reduction of hexavalent chromium.	tet	70-82	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
34236640-0	2021	Analysis of the Contribution of NF-kappaB in the Regulation of Chemotherapy-Induced Cell Senescence by Establishing a Tetracycline-Regulated Cell System.	tet	118-130	nuclear factor kappa B subunit 1	Homo sapiens	32-41
35533931-4	2022	The obtained BiOI(001)/CdS material shown the maximum degradation for tetracycline-based antibiotics (Oxytetracycline, Tetracycline and Doxycycline), and excellent reduction of hexavalent chromium.	tet	119-131	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
35182855-3	2022	Under simulated sunlight illumination, the apparent rate constant of tetracycline (TC) degradation by PCB reached 2.6 times that of gCB.	tet	83-85	glucosylceramidase beta	Homo sapiens	132-135
35398294-2	2022	To investigate whether FoxA factors alone are sufficient to drive chondrocyte hypertrophy, we build a FoxA2 transgenic mouse in which FoxA2 cDNA is driven by a reiterated Tetracycline Response Element (TRE) and a minimal CMV promoter.	tet	171-183	forkhead box A2	Mus musculus	102-107
35398294-2	2022	To investigate whether FoxA factors alone are sufficient to drive chondrocyte hypertrophy, we build a FoxA2 transgenic mouse in which FoxA2 cDNA is driven by a reiterated Tetracycline Response Element (TRE) and a minimal CMV promoter.	tet	171-183	forkhead box A2	Mus musculus	134-139
35580746-3	2022	Because Cu2+ can enhance the adsorption of CS/PEO NFM for TC, Cu@CS/PEO NFM possess a more sensitive response ability to TC, ensuring that the colorimetric sensing detection will not be interfered by other coexisting drugs.	tet	121-123	citrate synthase	Homo sapiens	43-45
35580746-3	2022	Because Cu2+ can enhance the adsorption of CS/PEO NFM for TC, Cu@CS/PEO NFM possess a more sensitive response ability to TC, ensuring that the colorimetric sensing detection will not be interfered by other coexisting drugs.	tet	121-123	citrate synthase	Homo sapiens	65-67
35257708-1	2022	In this work, the effect of Co substitution in the Fe1-xS (CSP) on the activation of H2O2 to degrade tetracycline (TC) is investigated.	tet	101-113	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	59-62
35257708-1	2022	In this work, the effect of Co substitution in the Fe1-xS (CSP) on the activation of H2O2 to degrade tetracycline (TC) is investigated.	tet	115-117	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	59-62
35257708-4	2022	The investigation of Behnajady-Modirshahla-Ghanbery kinetic model (BMG) showed that the maximum initial degradation rate of TC over 1.0% CSP/H2O2 was 1.6 times than that of in CSP/H2O2 system.	tet	124-126	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	137-140
35257708-4	2022	The investigation of Behnajady-Modirshahla-Ghanbery kinetic model (BMG) showed that the maximum initial degradation rate of TC over 1.0% CSP/H2O2 was 1.6 times than that of in CSP/H2O2 system.	tet	124-126	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	176-179
35257708-6	2022	The quenching experiments and ESR determined that  OH,  O2- and 1O2 were involved in TC degradation with the treatment of 1.0% CSP/H2O2 system.	tet	85-87	immunoglobulin kappa variable 1D-39	Homo sapiens	56-67
35257708-6	2022	The quenching experiments and ESR determined that  OH,  O2- and 1O2 were involved in TC degradation with the treatment of 1.0% CSP/H2O2 system.	tet	85-87	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	127-130
35398471-5	2022	The Fe electrode achieved 99.3% TC removal after 60 min in a single pollutant system containing 15 mgL-1 of TC, while the Al electrode achieved 99.8% removal in 20 min at optimal conditions.	tet	108-110	LLGL scribble cell polarity complex component 1	Homo sapiens	99-104
35580746-1	2022	Using electrospun chitosan/polyethylene oxide nanofibers mat (CS/PEO NFM) as carrier, Cu@CS/PEO NFM, a new tetracycline (TC) solid-state colorimetric sensor, were simply prepared by directly immobilizing Cu2+ on surface of CS/PEO NFM.	tet	107-119	citrate synthase	Homo sapiens	89-91
35580746-2	2022	After immersing in TC solutions, Cu@CS/PEO NFM can display visible color changes to the naked eye within 5.0 min, and the TC concentration-dependent color changes can also be quantitatively analyzed with a smartphone.	tet	19-21	citrate synthase	Homo sapiens	36-38
35580746-2	2022	After immersing in TC solutions, Cu@CS/PEO NFM can display visible color changes to the naked eye within 5.0 min, and the TC concentration-dependent color changes can also be quantitatively analyzed with a smartphone.	tet	122-124	citrate synthase	Homo sapiens	36-38
35580746-3	2022	Because Cu2+ can enhance the adsorption of CS/PEO NFM for TC, Cu@CS/PEO NFM possess a more sensitive response ability to TC, ensuring that the colorimetric sensing detection will not be interfered by other coexisting drugs.	tet	58-60	citrate synthase	Homo sapiens	43-45
35580746-3	2022	Because Cu2+ can enhance the adsorption of CS/PEO NFM for TC, Cu@CS/PEO NFM possess a more sensitive response ability to TC, ensuring that the colorimetric sensing detection will not be interfered by other coexisting drugs.	tet	58-60	citrate synthase	Homo sapiens	65-67
35325739-0	2022	Highly enhanced heterogeneous photo-Fenton process for tetracycline degradation by Fe/SCN Fenton-like catalyst.	tet	55-67	sorcin	Homo sapiens	86-89
35325739-1	2022	To suppress the electron-hole recombination and enhance the electron transfer on carbon nitride, an Fe-doped porous carbon nitride catalyst (Fe/SCN) was synthesized via supramolecular self-assembly method and applied in heterogeneous Fenton activation for efficient tetracycline (TC) degradation.	tet	266-278	sorcin	Homo sapiens	144-147
35325739-1	2022	To suppress the electron-hole recombination and enhance the electron transfer on carbon nitride, an Fe-doped porous carbon nitride catalyst (Fe/SCN) was synthesized via supramolecular self-assembly method and applied in heterogeneous Fenton activation for efficient tetracycline (TC) degradation.	tet	280-282	sorcin	Homo sapiens	144-147
35325739-5	2022	Three possible pathways of TC degradation were proposed, and the biological inhibition test revealed the potential of Fe/SCN/H2O2 system to reduce environmental risks caused by TC.	tet	27-29	sorcin	Homo sapiens	121-124
35325739-5	2022	Three possible pathways of TC degradation were proposed, and the biological inhibition test revealed the potential of Fe/SCN/H2O2 system to reduce environmental risks caused by TC.	tet	177-179	sorcin	Homo sapiens	121-124
35182855-3	2022	Under simulated sunlight illumination, the apparent rate constant of tetracycline (TC) degradation by PCB reached 2.6 times that of gCB.	tet	69-81	pyruvate carboxylase	Homo sapiens	102-105
35182855-3	2022	Under simulated sunlight illumination, the apparent rate constant of tetracycline (TC) degradation by PCB reached 2.6 times that of gCB.	tet	69-81	glucosylceramidase beta	Homo sapiens	132-135
35182855-3	2022	Under simulated sunlight illumination, the apparent rate constant of tetracycline (TC) degradation by PCB reached 2.6 times that of gCB.	tet	83-85	pyruvate carboxylase	Homo sapiens	102-105
35596852-7	2022	Releasing ALP enzyme from MC3T3 cells increased by tetracycline, so it is suitable candidate as osteoinductive and antibacterial agent in orthopedic implants coatings.	tet	51-63	alopecia, recessive	Mus musculus	10-13
35298927-8	2022	Moreover, the minimum bactericidal concentration (MBC) of AgNPs was 64 mug mL-1, which was significantly less than the determined value of 256 mug mL-1 for tetracycline.	tet	156-168	L1 cell adhesion molecule	Mus musculus	147-151
35192914-7	2022	Here, we describe how we developed a novel tetracycline-inducible gain-of-function Bmi1 (iBmi1) transgenic mouse model.	tet	43-55	Bmi1 polycomb ring finger oncogene	Mus musculus	83-87
35581596-7	2022	Tetracycline enabled mutant GFM1 fibroblasts survival under nutritional stress.	tet	0-12	G elongation factor mitochondrial 1	Homo sapiens	28-32
35236025-4	2022	Under the condition of only 0.1 mM sodium persulfate (PS) and 0.1 g/L catalyst, the removal rate of tetracycline (TC) reached 82.5% after 30 min of LED illumination, which greatly improved the utilization of oxidant.	tet	100-112	small integral membrane protein 10 like 2A	Homo sapiens	148-151
35236025-4	2022	Under the condition of only 0.1 mM sodium persulfate (PS) and 0.1 g/L catalyst, the removal rate of tetracycline (TC) reached 82.5% after 30 min of LED illumination, which greatly improved the utilization of oxidant.	tet	114-116	small integral membrane protein 10 like 2A	Homo sapiens	148-151
35114256-1	2022	In this study, a fast one-pot method was developed for the preparation of Cu/CS/Si ternary composites, which can efficiently remove antibiotic tetracycline from aqueous solutions.	tet	143-155	citrate synthase	Homo sapiens	77-79
35114256-2	2022	Our results demonstrated that the Cu and its content in the composites played a significant role in determining the physical properties and internal morphology of the Cu/CS/Si composites, which subsequently affected the efficiency of the composites for the sorptive removal of tetracycline.	tet	277-289	citrate synthase	Homo sapiens	170-172
35114256-3	2022	Among the studied composites, Cu3-CS2-Si materials had the largest sorption capacity for tetracycline (1076.7 mg/g) with a fast sorption kinetics (>99% in 30 min) under a broad working pH range (5-10).	tet	89-101	chorionic somatomammotropin hormone 2	Homo sapiens	34-37
35114256-4	2022	The results from the batch sorption experiments, together with spectroscopic and microscopic analyses, collectively indicated that Cu-tetracycline inner-sphere surface complexation through Cu-O bond was responsible for the tetracycline sorption on Cu3-CS2-Si.	tet	223-235	chorionic somatomammotropin hormone 2	Homo sapiens	252-255
35114256-5	2022	In addition, the Cu3-CS2-Si showed an excellent reusability in removing tetracycline.	tet	72-84	chorionic somatomammotropin hormone 2	Homo sapiens	21-24
35114256-6	2022	The desired sorption and reuse properties, coupled with the facile and cost-effective synthesis method, indicated that Cu/CS/Si composites have a promising potential for the efficient removal of tetracycline from contaminated solutions.	tet	195-207	citrate synthase	Homo sapiens	122-124
35592033-4	2022	Here, we generated Vip tTA knock-in mice that express tetracycline transactivator (tTA) specifically in VIP neurons by inserting tTA sequence at the start codon of Vip gene.	tet	54-66	vasoactive intestinal polypeptide	Mus musculus	19-22
35592033-4	2022	Here, we generated Vip tTA knock-in mice that express tetracycline transactivator (tTA) specifically in VIP neurons by inserting tTA sequence at the start codon of Vip gene.	tet	54-66	vasoactive intestinal polypeptide	Mus musculus	104-107
35592033-4	2022	Here, we generated Vip tTA knock-in mice that express tetracycline transactivator (tTA) specifically in VIP neurons by inserting tTA sequence at the start codon of Vip gene.	tet	54-66	vasoactive intestinal polypeptide	Mus musculus	164-167
35442652-5	2022	Furthermore, we synthesized x% PTh/Co9W10 composites (PTh = polythiophene, x = 0.5, 1, 2, 5) for photodegradation of tetracycline hydrochloride (TH) to evaluate the photocatalytic activities of title composites.	tet	117-143	parathyroid hormone	Homo sapiens	31-34
35442652-5	2022	Furthermore, we synthesized x% PTh/Co9W10 composites (PTh = polythiophene, x = 0.5, 1, 2, 5) for photodegradation of tetracycline hydrochloride (TH) to evaluate the photocatalytic activities of title composites.	tet	145-147	parathyroid hormone	Homo sapiens	31-34
35442652-5	2022	Furthermore, we synthesized x% PTh/Co9W10 composites (PTh = polythiophene, x = 0.5, 1, 2, 5) for photodegradation of tetracycline hydrochloride (TH) to evaluate the photocatalytic activities of title composites.	tet	145-147	parathyroid hormone	Homo sapiens	54-57
35625216-2	2022	The intrinsic resistance of M. abscessus towards first- and second-generation tetracyclines is mainly due to the over-expression of a tetracycline-degrading enzyme known as MabTetX (MAB_1496c).	tet	134-146	MAB_1496c	Mycobacterium abscessus	182-191
35113224-1	2022	BACKGROUND: Although pre-emptive therapy with oral tetracycline, moisturizer, sunscreen, and topical corticosteroid is useful for preventing acneiform eruption (AfE) due to epidermal growth factor receptor (EGFR) inhibitors, no studies have examined the efficacy of topical corticosteroids themselves, or investigated the optimal potency of corticosteroid for treating facial AfE (FAfE).	tet	51-63	epidermal growth factor receptor	Homo sapiens	173-205
35113224-1	2022	BACKGROUND: Although pre-emptive therapy with oral tetracycline, moisturizer, sunscreen, and topical corticosteroid is useful for preventing acneiform eruption (AfE) due to epidermal growth factor receptor (EGFR) inhibitors, no studies have examined the efficacy of topical corticosteroids themselves, or investigated the optimal potency of corticosteroid for treating facial AfE (FAfE).	tet	51-63	epidermal growth factor receptor	Homo sapiens	207-211
35427127-4	2022	A pseudo-univariate calibration curve of the resolved emission spectra intensity against the concentration of the mentioned antibiotics was linear in the range of 5-5000 ng mL-1 for AMP and 50-5000 ng mL-1 for TC and SAC.	tet	210-212	L1 cell adhesion molecule	Mus musculus	201-205
35583915-0	2022	Nano-chemically Modified Tetracycline-3 (nCMT-3) Attenuates Acute Lung Injury via Blocking sTREM-1 Release and NLRP3 Inflammasome Activation.	tet	25-37	NLR family, pyrin domain containing 3	Mus musculus	111-116
35566244-6	2022	The adsorption performances of the novel polymeric adsorbents, PAB1, PAB2, and PAB3, were tested in the adsorption of three antibiotics, tetracycline, sulfamethoxazole, and amoxicillin, from aqueous solutions, by using extensive kinetic, equilibrium, and thermodynamic studies.	tet	137-149	poly(A) binding protein cytoplasmic 1 pseudogene 10	Homo sapiens	63-67
35090121-4	2022	The 2.5Cu/CeO2/PMS system was capable of achieving the efficient removal of pollutants, including tetracycline, oxytetracycline, and rhodamine B, in a wide pH working range.	tet	98-110	proline rich protein BstNI subfamily 1	Homo sapiens	15-18
35440032-4	2022	METHODS: We developed a tetracycline-regulated, MMTV (mouse mammary tumor virus)-driven model of PTHrP overexpression in mammary epithelial cells (Tet-PTHrP mice) and bred these mice with the MMTV-PyMT (polyoma middle tumor-antigen) breast cancer model to analyze the impact of PTHrP overexpression on normal mammary gland biology and in breast cancer progression.	tet	24-36	parathyroid hormone like hormone	Homo sapiens	97-102
35440032-4	2022	METHODS: We developed a tetracycline-regulated, MMTV (mouse mammary tumor virus)-driven model of PTHrP overexpression in mammary epithelial cells (Tet-PTHrP mice) and bred these mice with the MMTV-PyMT (polyoma middle tumor-antigen) breast cancer model to analyze the impact of PTHrP overexpression on normal mammary gland biology and in breast cancer progression.	tet	24-36	parathyroid hormone like hormone	Homo sapiens	151-156
35440032-4	2022	METHODS: We developed a tetracycline-regulated, MMTV (mouse mammary tumor virus)-driven model of PTHrP overexpression in mammary epithelial cells (Tet-PTHrP mice) and bred these mice with the MMTV-PyMT (polyoma middle tumor-antigen) breast cancer model to analyze the impact of PTHrP overexpression on normal mammary gland biology and in breast cancer progression.	tet	24-36	parathyroid hormone like hormone	Homo sapiens	278-283
35436450-3	2022	On the basis of these advantages, the short-circuit current and maximum power density were increased by 5.1 and 1.2 times, and the respective removal efficiency of tetracycline hydrochloride (TCH) and hexavalent chromium (Cr(VI)) was increased by 29% and 32% in BOCI/CNCl/rGH, comparing with BOCI/CNCl/FTO.	tet	164-190	gamma-glutamyl hydrolase	Rattus norvegicus	272-275
35436450-3	2022	On the basis of these advantages, the short-circuit current and maximum power density were increased by 5.1 and 1.2 times, and the respective removal efficiency of tetracycline hydrochloride (TCH) and hexavalent chromium (Cr(VI)) was increased by 29% and 32% in BOCI/CNCl/rGH, comparing with BOCI/CNCl/FTO.	tet	192-195	gamma-glutamyl hydrolase	Rattus norvegicus	272-275
35392923-13	2022	To analyze the functionality of the NOS2-2 protein, we transfected human DLD-1 cells with tetracycline inducible expression clones encoding the NOS2-1- or -2 coding sequence.	tet	90-102	nitric oxide synthase 2	Homo sapiens	36-42
35392923-13	2022	To analyze the functionality of the NOS2-2 protein, we transfected human DLD-1 cells with tetracycline inducible expression clones encoding the NOS2-1- or -2 coding sequence.	tet	90-102	nitric oxide synthase 2	Homo sapiens	144-148
35392923-14	2022	After induction of the NOS2-1 or -2 mRNA expression by tetracycline a similar nitrate production was measured proofing the functionality of the NOS2-2 protein isoform.	tet	55-67	nitric oxide synthase 2	Homo sapiens	23-27
35388085-5	2022	The two domains of MMP1 prefer open conformations that are inhibited by a single point mutation E219Q of MMP1 and tetracycline, an MMP inhibitor.	tet	114-126	matrix metallopeptidase 1	Homo sapiens	19-23
35388085-5	2022	The two domains of MMP1 prefer open conformations that are inhibited by a single point mutation E219Q of MMP1 and tetracycline, an MMP inhibitor.	tet	114-126	matrix metallopeptidase 1	Homo sapiens	131-134
35115371-4	2022	To that end, we performed ChIP-seq, RNA-seq, 4C-seq and SIQHiC (Spike-in Quantitative Hi-C) on the U2OS osteosarcoma cell line with tetracycline-inducible MYC MYC overexpression in U2OS cells modulated histone acetylation and increased MYC binding at superenhancers.	tet	132-144	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	155-158
35115371-4	2022	To that end, we performed ChIP-seq, RNA-seq, 4C-seq and SIQHiC (Spike-in Quantitative Hi-C) on the U2OS osteosarcoma cell line with tetracycline-inducible MYC MYC overexpression in U2OS cells modulated histone acetylation and increased MYC binding at superenhancers.	tet	132-144	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	159-162
35115371-4	2022	To that end, we performed ChIP-seq, RNA-seq, 4C-seq and SIQHiC (Spike-in Quantitative Hi-C) on the U2OS osteosarcoma cell line with tetracycline-inducible MYC MYC overexpression in U2OS cells modulated histone acetylation and increased MYC binding at superenhancers.	tet	132-144	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	236-239
35246205-5	2022	We first prepared orexin-knockout mice crossed with transgenic mice carrying a tetracycline-controlled transactivator transgene under the control of the orexin promoter.	tet	79-91	hypocretin	Mus musculus	153-159
35352492-12	2022	CONCLUSIONS: The results of this meta-analysis reinforce the fact that oral tetracycline antibiotics are the most efficacious prophylactic option for acneiform eruptions in EGFR inhibitors.	tet	76-88	epidermal growth factor receptor	Homo sapiens	173-177
35331970-2	2022	A controllable tetracycline-inducible AID (Tet-On) expression system of activation-induced cytidine deaminase (AID) was generated in an anti-influenza B virus monoclonal IgM hybridoma 7G1 and single cell lines with four kinds of mouse IgG subclasses were isolated.	tet	15-27	activation induced cytidine deaminase	Homo sapiens	38-41
35331970-2	2022	A controllable tetracycline-inducible AID (Tet-On) expression system of activation-induced cytidine deaminase (AID) was generated in an anti-influenza B virus monoclonal IgM hybridoma 7G1 and single cell lines with four kinds of mouse IgG subclasses were isolated.	tet	15-27	activation induced cytidine deaminase	Homo sapiens	72-109
35331970-2	2022	A controllable tetracycline-inducible AID (Tet-On) expression system of activation-induced cytidine deaminase (AID) was generated in an anti-influenza B virus monoclonal IgM hybridoma 7G1 and single cell lines with four kinds of mouse IgG subclasses were isolated.	tet	15-27	activation induced cytidine deaminase	Homo sapiens	111-114
35058078-0	2022	Dietary supplementation with gamma-linolenic, linoleic and oleic acids decreases PPAR-gamma expression and helps the tetracycline derivative to reduce NOD2 expression in patients with acne vulgaris.	tet	117-129	nucleotide binding oligomerization domain containing 2	Homo sapiens	151-155
35043131-4	2022	The optimized ZIS/TCN-3 exhibits superb photocatalytic efficiency for the degradation of tetracycline (86.1%, 60 min), maintains excellent stability and recyclability, and provides a facile strategy for the synthesis of efficient heterojuction photocatalysts towards wastewater treatment.	tet	89-101	zinc finger RANBP2-type containing 2	Homo sapiens	14-17
35223826-3	2022	Adipose-derived mesenchymal cells were lentivirally transduced with tetracycline-inducible Sox10, Olig2, Zfp536, and/or Nkx6.1 transgenes.	tet	68-80	SRY-box transcription factor 10	Rattus norvegicus	91-96
35223826-3	2022	Adipose-derived mesenchymal cells were lentivirally transduced with tetracycline-inducible Sox10, Olig2, Zfp536, and/or Nkx6.1 transgenes.	tet	68-80	oligodendrocyte transcription factor 2	Rattus norvegicus	98-103
35223826-3	2022	Adipose-derived mesenchymal cells were lentivirally transduced with tetracycline-inducible Sox10, Olig2, Zfp536, and/or Nkx6.1 transgenes.	tet	68-80	zinc finger protein 536	Rattus norvegicus	105-111
35223826-3	2022	Adipose-derived mesenchymal cells were lentivirally transduced with tetracycline-inducible Sox10, Olig2, Zfp536, and/or Nkx6.1 transgenes.	tet	68-80	NK6 homeobox 1	Rattus norvegicus	120-126
35043131-4	2022	The optimized ZIS/TCN-3 exhibits superb photocatalytic efficiency for the degradation of tetracycline (86.1%, 60 min), maintains excellent stability and recyclability, and provides a facile strategy for the synthesis of efficient heterojuction photocatalysts towards wastewater treatment.	tet	89-101	cobalamin binding intrinsic factor	Homo sapiens	18-23
35164076-2	2022	In our previous work, we developed a tetracycline-off regulated expression of CD44"s gene in the breast cancer (BC) cell line MCF-7 (B5 clone).	tet	37-49	CD44 molecule (Indian blood group)	Homo sapiens	78-82
35130879-0	2022	Tetracycline ameliorates silica-induced pulmonary inflammation and fibrosis via inhibition of caspase-1.	tet	0-12	caspase 1	Mus musculus	94-103
35130879-4	2022	Recent studies indicate that tetracycline can be used to treat inflammatory diseases mediated by IL-1beta and IL-18.	tet	29-41	interleukin 1 alpha	Mus musculus	97-105
35130879-4	2022	Recent studies indicate that tetracycline can be used to treat inflammatory diseases mediated by IL-1beta and IL-18.	tet	29-41	interleukin 18	Mus musculus	110-115
35130879-5	2022	Therefore, we hypothesized that tetracycline reduces silica-induced lung injury and lung fibrosis resulting from chronic silicosis via limiting IL-1beta and IL-18 driven inflammation.	tet	32-44	interleukin 1 alpha	Mus musculus	144-152
35130879-5	2022	Therefore, we hypothesized that tetracycline reduces silica-induced lung injury and lung fibrosis resulting from chronic silicosis via limiting IL-1beta and IL-18 driven inflammation.	tet	32-44	interleukin 18	Mus musculus	157-162
35130879-8	2022	RESULTS: Tetracycline selectively blocks IL-1beta production and pyroptotic cell death via inhibition of caspase-1 in macrophages exposed to silica particles.	tet	9-21	interleukin 1 alpha	Mus musculus	41-49
35130879-8	2022	RESULTS: Tetracycline selectively blocks IL-1beta production and pyroptotic cell death via inhibition of caspase-1 in macrophages exposed to silica particles.	tet	9-21	caspase 1	Mus musculus	105-114
35130879-9	2022	Consistent, treatment of silica-instilled mice with tetracycline significantly reduced pulmonary caspase-1 activation as well as IL-1beta and IL-18 production, thereby ameliorating pulmonary inflammation and lung injury.	tet	52-64	caspase 1	Mus musculus	97-106
35130879-9	2022	Consistent, treatment of silica-instilled mice with tetracycline significantly reduced pulmonary caspase-1 activation as well as IL-1beta and IL-18 production, thereby ameliorating pulmonary inflammation and lung injury.	tet	52-64	interleukin 1 alpha	Mus musculus	129-137
35130879-9	2022	Consistent, treatment of silica-instilled mice with tetracycline significantly reduced pulmonary caspase-1 activation as well as IL-1beta and IL-18 production, thereby ameliorating pulmonary inflammation and lung injury.	tet	52-64	interleukin 18	Mus musculus	142-147
35130879-11	2022	CONCLUSIONS: These findings suggest that tetracycline inhibits caspase-1-dependent production of IL-1beta in response to silica in vitro and in vivo.	tet	41-53	caspase 1	Mus musculus	63-72
35130879-11	2022	CONCLUSIONS: These findings suggest that tetracycline inhibits caspase-1-dependent production of IL-1beta in response to silica in vitro and in vivo.	tet	41-53	interleukin 1 alpha	Mus musculus	97-105
35175912-10	2022	The MYCO WELL D-ONE kit overestimated tetracycline and erythromycin resistance in Ureaplasma spp.	tet	38-50	histocompatibility minor 13	Homo sapiens	93-96
35160743-4	2022	In this study, density functional theory is used to analyze the interaction mechanism of TC, oxytetracycline (OTC), chlortetracycline, and HAp.	tet	89-91	reticulon 3	Homo sapiens	139-142
34982395-4	2022	Thus, we exploited mutant mice in which the Bdnf expression level is regulated by the tetracycline-dependent transcriptional silencer (tTS)-tetracycline operator sequence (tetO) system.	tet	86-98	brain derived neurotrophic factor	Mus musculus	44-48
34935807-3	2022	Herein, a novel Z-scheme heterojunction photocatalyst O-doped g-C3N4/WO3 (OCN/W) was fabricated and used for the photocatalytic degradation of tetracycline (TC) at different dissolved oxygen concentrations.	tet	143-155	bone gamma-carboxyglutamate protein	Homo sapiens	74-77
34935807-3	2022	Herein, a novel Z-scheme heterojunction photocatalyst O-doped g-C3N4/WO3 (OCN/W) was fabricated and used for the photocatalytic degradation of tetracycline (TC) at different dissolved oxygen concentrations.	tet	157-159	bone gamma-carboxyglutamate protein	Homo sapiens	74-77
34935807-5	2022	The TC removal rate of OCN/W-2.0 is 89.8% within 60 min under visible light irradiation, which is 1.77 times higher than that of porous g-C3N4 nanosheets (PCN).	tet	4-6	bone gamma-carboxyglutamate protein	Homo sapiens	23-26
34983642-12	2022	Genotypic analysis of antibiotic resistance of strain S16 confirmed resistance to amikacin, ciprofloxacin, sulfamethoxazole, streptomycin, and tetracycline.	tet	143-155	ribosomal protein S16	Homo sapiens	54-57
34985258-7	2022	Results show that PPMD@Cu/TC exhibits significant great photothermal properties with NIR irradiation, which induces the release of Cu2+, while inducing PCM melting and, subsequent, TC release.	tet	26-28	immunoglobulin kappa variable 1-35	Mus musculus	131-134
34982395-4	2022	Thus, we exploited mutant mice in which the Bdnf expression level is regulated by the tetracycline-dependent transcriptional silencer (tTS)-tetracycline operator sequence (tetO) system.	tet	140-152	brain derived neurotrophic factor	Mus musculus	44-48
34550576-4	2022	This chapter details a new method for accessing the Black and Leff operational model of agonism using a stable Flp-In  T-REx  HEK293 cell line under tetracycline-dependent control of OTR expression.	tet	149-161	oxytocin receptor	Homo sapiens	183-186
35047507-3	2021	In order to explore the specific functions of BIRC5 gene in multi-drug resistance (MDR), a CRISPR/Cas9-mediated knocking-in tetracycline (Tet)-off regulatory system cell line was established, which enabled us to regulate the expression levels of Survivin quantitatively (clone 8 named MCF-7/Survivin was selected for further studies).	tet	124-136	baculoviral IAP repeat containing 5	Homo sapiens	46-51
35047507-3	2021	In order to explore the specific functions of BIRC5 gene in multi-drug resistance (MDR), a CRISPR/Cas9-mediated knocking-in tetracycline (Tet)-off regulatory system cell line was established, which enabled us to regulate the expression levels of Survivin quantitatively (clone 8 named MCF-7/Survivin was selected for further studies).	tet	138-141	baculoviral IAP repeat containing 5	Homo sapiens	46-51
34705344-11	2022	Tetracycline resistance was detected in 82 isolates, mostly caused by the tetB gene.	tet	0-12	TetB	Escherichia coli	74-78
2695953-5	1989	The amounts of extractable plasmid DNA were also increased by SOS induction, and we propose that the SOS-induced increases in levels of tetracycline resistance and beta-lactamase activity are due to an increased plasmid copy number.	tet	136-148	xylosyltransferase 2	Homo sapiens	62-65
2692515-3	1989	A beta-lactamase with an isoelectric point (pI) of 5.9 was detected in strain CB-134, and the corresponding gene was transferred by conjugation to E. coli together with the associated aminoglycoside resistance determinant [AAC(3)-II] and tetracycline, trimethoprim, and sulfonamide resistance.	tet	238-250	aminoglycoside N(3')-acetyltransferase III	Escherichia coli	223-232
2695953-5	1989	The amounts of extractable plasmid DNA were also increased by SOS induction, and we propose that the SOS-induced increases in levels of tetracycline resistance and beta-lactamase activity are due to an increased plasmid copy number.	tet	136-148	xylosyltransferase 2	Homo sapiens	101-104
2656382-2	1989	The beta-lactamase gene was carried on a plasmid (pUK734) along with resistance determinants to sulphonamides and tetracycline.	tet	114-126	beta-lactamase	Escherichia coli	4-18
2496174-2	1989	Monthly surveillance of gonococcal isolates showed the prevalence of gonococci with high-level, plasmid-mediated tetracycline resistance (TRNG) to be about 15% for three consecutive 6-mo periods.	tet	113-125	mitochondrially encoded tRNA glycine	Homo sapiens	138-142
3337725-0	1988	Similarity between the estrogen receptor and the DNA-binding domain of the tetracycline repressor.	tet	75-87	estrogen receptor 1	Homo sapiens	23-40
3266953-0	1988	Tumor necrosis factor alpha and interleukin-1 stimulate bone resorption in vivo as measured by urinary [3H]tetracycline excretion from prelabeled mice.	tet	107-119	tumor necrosis factor	Mus musculus	0-27
3135097-6	1988	(2) Dynamic behavior in tetracycline based studies disclosed the appearance of two populations of DCD: a subgroup of preserved calcification dynamics with values not quite different than the NDCD group and a subgroup with a significant derangement of mineralization with no measurable bone trabecular dynamics.	tet	24-36	dermcidin	Homo sapiens	98-101
2736152-9	1989	Tetracycline uptake was significantly lower in the groups treated with CT at doses above 1.0 MRC unit/kg.	tet	0-12	calcitonin-related polypeptide alpha	Rattus norvegicus	71-73
3142848-6	1988	Induction of the tet gene by tetracycline resulted in a 4-fold increase in the levels of TET mRNA and at least a 15-fold increase in the amount of TET protein in B. subtilis minicells.	tet	29-41	tetracycline-resistance protein	Staphylococcus aureus	89-92
3142848-6	1988	Induction of the tet gene by tetracycline resulted in a 4-fold increase in the levels of TET mRNA and at least a 15-fold increase in the amount of TET protein in B. subtilis minicells.	tet	29-41	tetracycline-resistance protein	Staphylococcus aureus	147-150
3134850-0	1988	High-level tetracycline resistance resulting from TetM in strains of Neisseria spp., Kingella denitrificans, and Eikenella corrodens.	tet	11-23	TetM	Neisseria gonorrhoeae	50-54
3134850-1	1988	Similar to Neisseria gonorrhoeae, tetracycline-resistant isolates of N. meningitidis, Kingella denitrificans, and Eikenella corrodens contained 25.2-megadalton plasmids carrying the TetM determinant.	tet	34-46	TetM	Neisseria gonorrhoeae	182-186
3134850-2	1988	In contrast, tetracycline-resistant N. subflava biovar perflava-N. sicca and N. mucosa isolates carried the TetM determinant in the chromosome.	tet	13-25	TetM	Neisseria gonorrhoeae	108-112
3132092-2	1988	The resistance in each species is due to the acquisition of 25.2-megadalton conjugative plasmids that carry the tetracycline resistance determinant TetM.	tet	112-124	TetM	Neisseria gonorrhoeae	148-152
3337725-2	1988	A computer-based comparison of a residues 18-61 of the tet repressor, which contains this DNA-binding domain, with a residues 304-347 of the human estrogen receptor (ER) yields a score that is 6.7 standard deviations higher than that obtained with 2,500 comparisons of randomized sequences of these segments.	tet	55-58	estrogen receptor 1	Homo sapiens	147-164
3337725-2	1988	A computer-based comparison of a residues 18-61 of the tet repressor, which contains this DNA-binding domain, with a residues 304-347 of the human estrogen receptor (ER) yields a score that is 6.7 standard deviations higher than that obtained with 2,500 comparisons of randomized sequences of these segments.	tet	55-58	estrogen receptor 1	Homo sapiens	166-168
3287101-10	1988	Penicillin G at 0.5 micrograms/ml (1/5 minimal inhibitory concentration: MIC) and tetracycline at 0.2 micrograms/ml (1/5 MIC), when included in the growth medium, suppressed the cell surface components responsible for fibronectin binding and fibroblast adhesion.	tet	82-94	fibronectin 1	Bos taurus	218-229
2826391-2	1988	Transposition of Tn4291 into pI524 occurred during the transduction of the tetracycline resistance plasmid pSN1 from a methicillin-resistant donor into a recipient that carried the mec allele in the primary site on the chromosome.	tet	75-87	5'-nucleotidase, cytosolic IIIA	Homo sapiens	107-111
3439801-0	1987	Subinhibitory concentrations of tetracycline alter fibrinogen binding by Bacteroides intermedius.	tet	32-44	fibrinogen beta chain	Homo sapiens	51-61
3439801-6	1987	We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC.	tet	71-83	fibrinogen beta chain	Homo sapiens	87-97
3439801-6	1987	We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC.	tet	71-83	fibrinogen beta chain	Homo sapiens	172-182
3439801-6	1987	We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC.	tet	228-240	fibrinogen beta chain	Homo sapiens	87-97
3439801-6	1987	We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC.	tet	228-240	fibrinogen beta chain	Homo sapiens	172-182
3439801-6	1987	We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC.	tet	228-240	fibrinogen beta chain	Homo sapiens	87-97
3439801-6	1987	We examined the effect of growth in subinhibitory levels (sub-MICs) of tetracycline on fibrinogen binding by these bacteria and found concentration-dependent inhibition of fibrinogen binding by bacteria grown in the presence of tetracycline over the range of tetracycline concentrations from 1/64 to 1/8 the MIC.	tet	228-240	fibrinogen beta chain	Homo sapiens	172-182
3439801-7	1987	Analysis of the binding data suggests that bacteria grown in the presence of sub-MICs of tetracycline bind fewer fibrinogen molecules per cell than do bacteria grown in the absence of the drug.	tet	89-101	fibrinogen beta chain	Homo sapiens	113-123
3439801-8	1987	If fibrinogen-mediated adherence is important in the establishment B. intermedius in periodontal lesions and lesions of acute necrotizing ulcerative gingivitis, then tetracycline may be effective in disrupting establishment of these organisms at concentrations well below those required to achieve a bacteriostatic effect.	tet	166-178	fibrinogen beta chain	Homo sapiens	3-13
3324958-1	1987	The class L (TetL) tetracycline resistance determinant from streptococci specified resistance and an energy-dependent decreased accumulation of tetracycline in both Streptococcus faecalis and Escherichia coli.	tet	19-31	TetL transporter	Enterococcus faecalis	13-17
3479727-0	1987	Tetracycline reduces the need for insulin.	tet	0-12	insulin	Homo sapiens	34-41
3039994-0	1987	O2- photogenerated from aqueous solutions of tetracycline antibiotics (pH 7.3) as evidenced by DMPO spin trapping and cytochrome c reduction.	tet	45-57	cytochrome c, somatic	Homo sapiens	118-130
3118797-5	1987	Plasmids isolated from three transconjugants resistant to tetracycline but susceptible to minocycline bore nucleotide sequences homologous to the tetL gene.	tet	58-70	TetL transporter	Enterococcus faecalis	146-150
3039994-1	1987	UV-irradiation of several tetracycline antibiotics in aqueous buffer (pH 7.3) resulted in the generation of the superoxide anion radical (O2-) which was detected by cytochrome c reduction and by spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide and was inhibited by superoxide dismutase.	tet	26-38	cytochrome c, somatic	Homo sapiens	165-177
3032905-2	1987	It was tetracycline resistant and had the carboxyl-terminal end of bla distal to its PstI site.	tet	7-19	serine peptidase inhibitor Kazal type 1	Homo sapiens	85-89
3111504-0	1987	Deletions in the tetracycline resistance determinant reduce the thermosensitivity of a trfA(Ts) derivative of plasmid RP1 in Pseudomonas aeruginosa.	tet	17-29	trfA	Klebsiella aerogenes	87-91
3295183-13	1987	We report that periodontal ligament (PDL) cells migrate towards FN and ECGF; that PDL cell migration is enhanced when dentin is preconditioned with tetracycline HCl; that PDL cells have an increased proliferative response when dentin is conditioned with both FN and ECGF; that gingival epithelial cells have increased migratory and proliferative responses when LM is used to condition dentin; and that there is a reciprocal utilization of biological response modifiers by gingival epithelial cells and PDL cells.	tet	148-164	fibronectin 1	Homo sapiens	259-261
3295183-13	1987	We report that periodontal ligament (PDL) cells migrate towards FN and ECGF; that PDL cell migration is enhanced when dentin is preconditioned with tetracycline HCl; that PDL cells have an increased proliferative response when dentin is conditioned with both FN and ECGF; that gingival epithelial cells have increased migratory and proliferative responses when LM is used to condition dentin; and that there is a reciprocal utilization of biological response modifiers by gingival epithelial cells and PDL cells.	tet	148-164	fibroblast growth factor 1	Homo sapiens	266-270
6093790-3	1984	Among tetracycline-resistant transformants, a number of colonies were found to contain cDNA sequence for glycine methyltransferase as examined by hybrid-selected translation.	tet	6-18	glycine N-methyltransferase	Rattus norvegicus	105-130
3035345-2	1987	To elucidate this polar effect, we constructed a plasmid which has an IS1 integrated between the 5" half of the tet gene for tetracycline resistance and the cat structural gene for chloramphenicol resistance.	tet	125-137	IS1	Homo sapiens	70-73
3099640-0	1986	High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant.	tet	11-23	TetM	Neisseria gonorrhoeae	102-106
3882669-3	1985	Transconjugants containing the nif/hup cosmid were identified by their resistance to tetracycline (Tcr) and ability to grow chemoautotrophically (Aut+) with hydrogen.	tet	85-97	DNA-binding protein HU	Escherichia coli	35-38
3963179-1	1986	The effect of local administration of growth hormone (GH) and insulinlike growth factor 1 (IGF-1) on longitudinal bone growth was studied in the proximal tibia of hypophysectomized rats, by using the tetracycline method.	tet	200-212	gonadotropin releasing hormone receptor	Rattus norvegicus	38-52
3026910-2	1986	We have isolated a plasmid pBR322 derivative having IS1 inserted into a site between the promoter and the structural gene for tetracycline resistance.	tet	126-138	translocator protein	Homo sapiens	27-30
3026910-2	1986	We have isolated a plasmid pBR322 derivative having IS1 inserted into a site between the promoter and the structural gene for tetracycline resistance.	tet	126-138	IS1	Homo sapiens	52-55
3932298-9	1985	faecium) streptococci, MLS resistance genes are also found on plasmids that carry other antibiotic resistance (tetracycline, chloramphenicol, high-levels of streptomycin and kanamycin).	tet	111-123	holocytochrome c synthase	Homo sapiens	23-26
4019625-2	1985	Application of prepacked C18 cartridge for the analysis of tetracycline residues in animal liver.	tet	59-71	Bardet-Biedl syndrome 9	Homo sapiens	25-28
2862065-4	1985	Tetracycline resistant clones containing DNA sequences coding for the full length of prochymosin were recognized by colony hybridization with five specific d-oligonucleotides corresponding either to the N-terminal, the middle or the C-terminal part of prochymosin.	tet	0-12	chymosin	Bos taurus	85-96
2862065-4	1985	Tetracycline resistant clones containing DNA sequences coding for the full length of prochymosin were recognized by colony hybridization with five specific d-oligonucleotides corresponding either to the N-terminal, the middle or the C-terminal part of prochymosin.	tet	0-12	chymosin	Bos taurus	252-263
6327464-3	1984	In plasmids pKK231 -1 and pKK232 -8 the gene for cam acetyltransferase (CAT) and in pKK175 -6 the gene for tet resistance are flanked by efficient transcription terminators, preventing transcription from other pBR322 promoters into the antibiotic resistance region.	tet	107-110	chloramphenicol acetyltransferase	Escherichia coli	49-70
6144827-3	1984	Serum BGP correlated positively with relative osteoid volume, relative osteoid surfaces, tetracycline labelled surfaces, and bone formation rate but not with resorption surfaces.	tet	89-101	bone gamma-carboxyglutamate protein	Homo sapiens	6-9
6330687-0	1984	Nucleotide sequence of the repressor gene of the TN10 tetracycline resistance determinant.	tet	54-66	repressor	Escherichia coli	27-36
6330687-1	1984	The Tn10 tetR gene encodes the repressor that regulates transcription of the Tn10 tetracycline resistance determinant.	tet	82-94	tetracycline resistance repressor protein TetR	Escherichia coli	9-13
6330687-1	1984	The Tn10 tetR gene encodes the repressor that regulates transcription of the Tn10 tetracycline resistance determinant.	tet	82-94	repressor	Escherichia coli	31-40
6327464-3	1984	In plasmids pKK231 -1 and pKK232 -8 the gene for cam acetyltransferase (CAT) and in pKK175 -6 the gene for tet resistance are flanked by efficient transcription terminators, preventing transcription from other pBR322 promoters into the antibiotic resistance region.	tet	107-110	chloramphenicol acetyltransferase	Escherichia coli	72-75
6404516-1	1983	After transformation of Escherichia coli strains with plasmid pBR 322 and growth in rich L medium, the total amount of beta-lactamase produced, strongly decreased when the temperature was raised from 30 to 42 degrees C, but increased after addition of ampicillin or tetracycline to the medium.	tet	266-278	beta-lactamase	Escherichia coli	119-133
6320824-3	1984	Ampicillin-sensitive and tetracycline-resistant colonies were screened by in situ hybridization with elastin-enriched mRNA that had been terminally labeled with 32p.	tet	25-37	elastin	Ovis aries	101-108
6237556-5	1984	The marked decline in protein synthesis in tetracycline treated cultures was accompanied by a significant suppression of MIF production.	tet	43-55	macrophage migration inhibitory factor	Homo sapiens	121-124
20487989-6	1983	Tetracycline-resistant ampicillin-sensitive clones were screened by positive hybridization selection, and preliminary screening identified 2 out of 36 clones containing phenylethanolamine N-methyltransferase cDNA inserts.	tet	0-12	phenylethanolamine N-methyltransferase	Bos taurus	169-207
6196945-3	1983	The effect of different inhibitors like actinomycin D, chloramphenicol, tetracycline, nitrofurantoin and rifampicin on histidase induction was also studied.	tet	72-84	histidine ammonia-lyase	Homo sapiens	119-128
6339187-0	1983	[Induction of directed mutations in the tetracycline resistance gene of plasmid pBR 322 using complementary single-stranded DNA fragments carrying alkylating groups].	tet	40-52	translocator protein	Homo sapiens	80-83
6286589-4	1982	When EcoRI fragment A of NR1 (20.5 kilobases) was cloned to RSF2124, the frequency of cotransfer of ampicillin resistance with tetracycline resistance was 25 to 60%.	tet	127-139	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	25-28
7153285-2	1982	Determination of tetracycline in plasma is based on precipitation of plasma proteins with trifluoroacetic acid, followed by injection of the centrifuged plasma sample onto a muBondapak C18 column.	tet	17-29	Bardet-Biedl syndrome 9	Homo sapiens	185-188
6286589-7	1982	When the cloned fragment was EcoRI fragment H of NR1 (4.8 kilobases), the frequency of cotransfer of ampicillin resistance with tetracycline resistance was about 4%, and the majority of the ampicillin-resistant transconjugants were found to contain cointegrate plasmids.	tet	128-140	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	49-52
7065646-3	1982	However, NAG-vibrio remain to be sensitive to tetracycline, chloramphenicol and gentamicin.	tet	46-58	NBAS subunit of NRZ tethering complex	Homo sapiens	9-12
7096266-1	1982	Bacteroides fragilis TMP10, which is clindamycin-erythromycin resistant (Clnr) and tetracycline resistant (Tetr), contains several plasmids and is capable of transferring drug resistance markers to suitable recipients.	tet	83-95	oligodendrocytic myelin paranodal and inner loop protein	Homo sapiens	21-26
7096266-7	1982	A complex interaction between the autonomous plasmid pBFTM10 and a tetracycline transfer element also present in strain TMP10 was observed since pretreatment of this donor with tetracycline or clindamycin resulted in a marked increase in transfer of both tetracycline and clindamycin resistance.	tet	67-79	oligodendrocytic myelin paranodal and inner loop protein	Homo sapiens	120-125
7096266-7	1982	A complex interaction between the autonomous plasmid pBFTM10 and a tetracycline transfer element also present in strain TMP10 was observed since pretreatment of this donor with tetracycline or clindamycin resulted in a marked increase in transfer of both tetracycline and clindamycin resistance.	tet	177-189	oligodendrocytic myelin paranodal and inner loop protein	Homo sapiens	120-125
7096266-7	1982	A complex interaction between the autonomous plasmid pBFTM10 and a tetracycline transfer element also present in strain TMP10 was observed since pretreatment of this donor with tetracycline or clindamycin resulted in a marked increase in transfer of both tetracycline and clindamycin resistance.	tet	177-189	oligodendrocytic myelin paranodal and inner loop protein	Homo sapiens	120-125
7123053-1	1982	Tetracycline-induced remission of the development of symptoms has been used as an aid in the diagnosis of plant diseases associated with mycoplasma-like organisms and, in a few cases, for field control of some tree diseases.	tet	0-12	activation induced cytidine deaminase	Homo sapiens	82-85
6177201-0	1982	Dissolution of tetracycline hydrochloride in mucin solutions.	tet	15-41	LOC100508689	Homo sapiens	45-50
7327922-3	1981	Tetracycline administration for three consecutive days in four normal subjects decreased serum CH50, C1q, C3, and C4 levels on day 4.	tet	0-12	complement C1q A chain	Homo sapiens	101-104
6210908-2	1982	DNA from Saccharomyces cerevisiae BAS2, in which the pBR322--ura 3 plasmid (Y1p5) is integrated at the yeast histone H2A and H2B locus, was used to generate a cosmid library, using a new cosmid vector (pTL5) that is ampicillin sensitive and tetracycline resistant.	tet	241-253	Pho2p	Saccharomyces cerevisiae S288C	34-38
6282690-6	1981	In the vectors pRC2 and pRC3, constructed from pRC1, the unique BamHI site is located within an intact tetracycline resistance gene, thus making it possible to screen bacterial transformants for those containing recombinant plasmid molecules.	tet	103-115	proteasome core particle subunit alpha 1	Saccharomyces cerevisiae S288C	15-19
6282690-6	1981	In the vectors pRC2 and pRC3, constructed from pRC1, the unique BamHI site is located within an intact tetracycline resistance gene, thus making it possible to screen bacterial transformants for those containing recombinant plasmid molecules.	tet	103-115	carboxypeptidase C PRC1	Saccharomyces cerevisiae S288C	47-51
6273826-3	1981	A total of forty-two tetracycline-resistant colonies were isolated, thirty of which contained circular pRK1 molecules identical to those originally injected.	tet	21-33	protein kinase N1	Homo sapiens	103-107
7029244-0	1981	[Subjection of tetracycline resistance genes to cat promotor gene in plasmid pBR325].	tet	15-27	translocator protein	Homo sapiens	77-80
7029244-1	1981	A series of plasmids with tetracycline resistance genes (Tcr-operon) subjected to transcription from chloramphenicol acetyl transferase promoter (Cmr-promoter) have been constructed on the basis of plasmid pBR325, AprCmrTcr.	tet	26-38	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	57-60
7029244-4	1981	Tetracycline resistance can be eliminated completely by the deletion of a) Cmr-promoter; b) part of the first Tcr-operon gene.	tet	0-12	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	110-113
7017708-3	1981	A most interesting signal arrangement was found at the beginning of the tetracycline resistance region, where two partially overlapping promoters (P1 and P2) initiate transcription crosswise in opposite directions.	tet	72-84	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	Homo sapiens	147-156
7205643-1	1981	Antiserum against tetracycline was produced in rabbits immunized with a tetracycline hapten conjugated to bovine serum albumin.	tet	18-30	albumin	Oryctolagus cuniculus	113-126
7243382-6	1981	At 6 degrees C, net influx for both antibiotics was less than the influx observed at 37 degrees C. Net influx again increased with increasing antibiotic concentrations in the bath but at a slower rate (0.29 ng/min.trachea per microgram/ml for chloramphenicol and 0.25 ng/min.trachea per microgram/ml for tetracycline).	tet	304-316	solute carrier family 6 member 2	Rattus norvegicus	99-102
883787-4	1977	The cyclic subsequent administration of oleandomycin and tetracycline for 7 days was accompanied by an increase in the lysozyme content and serum bactericidal properties.	tet	57-69	lysozyme C-like	Oryctolagus cuniculus	119-127
6254059-6	1980	Sixty-three tetracycline-resistant clones were obtained that hybridized to 32P-labeled cDNA synthesized from prothrombin-enriched mRNA.	tet	12-24	coagulation factor II, thrombin	Bos taurus	109-120
6453204-8	1980	Two similar plasmids cp-2 and cp-3 were able to promote their own transfer through clones of 1030; plasmids coding for resistance to either neomycin or tetracycline could be transferred to a recipient by the presence of cp-2 or cp-3 simultaneously in the donor.	tet	152-164	ceruloplasmin	Homo sapiens	21-25
6453204-8	1980	Two similar plasmids cp-2 and cp-3 were able to promote their own transfer through clones of 1030; plasmids coding for resistance to either neomycin or tetracycline could be transferred to a recipient by the presence of cp-2 or cp-3 simultaneously in the donor.	tet	152-164	ceruloplasmin	Homo sapiens	220-224
7361727-0	1980	Transient deficiency of antihemophilic factor (AHF) procoagulant and AHF-like antigen during administration of tetracycline.	tet	111-123	coagulation factor VIII	Homo sapiens	24-45
7361727-0	1980	Transient deficiency of antihemophilic factor (AHF) procoagulant and AHF-like antigen during administration of tetracycline.	tet	111-123	coagulation factor VIII	Homo sapiens	47-50
7361727-0	1980	Transient deficiency of antihemophilic factor (AHF) procoagulant and AHF-like antigen during administration of tetracycline.	tet	111-123	coagulation factor VIII	Homo sapiens	69-72
7361727-1	1980	A 35-year old woman showed a transient reduction in level of both moieties of antihemophilic factor (AHF; factor VIII, AHG), following the accidental administration of oral tetracycline.	tet	173-185	coagulation factor VIII	Homo sapiens	78-99
7361727-1	1980	A 35-year old woman showed a transient reduction in level of both moieties of antihemophilic factor (AHF; factor VIII, AHG), following the accidental administration of oral tetracycline.	tet	173-185	coagulation factor VIII	Homo sapiens	101-104
722486-4	1978	Introduction of a hydroxyl group at C-5 on the tetracycline nucleus promoted partitioning through an entropy-dominated decrease in the "apparent" free energy of partitioning, whereas shifting the hydroxyl group to C-6beta retarded partitioning due to an enthalpy-dominated gain in the apparent free energy.	tet	47-59	complement C5	Homo sapiens	36-39
152604-3	1978	On the basis of the activity comparison of the Mg2+- and Ca2+-activated ATP-ase of the membrane fraction of the tetracycline sensitive and resistance strains of E. coli it was concluded that the resistance development in the strains tested to tetracycline was not associated with the changes in the ATP-ase activity.	tet	112-124	ATPase	Escherichia coli	72-79
152604-3	1978	On the basis of the activity comparison of the Mg2+- and Ca2+-activated ATP-ase of the membrane fraction of the tetracycline sensitive and resistance strains of E. coli it was concluded that the resistance development in the strains tested to tetracycline was not associated with the changes in the ATP-ase activity.	tet	112-124	ATPase	Escherichia coli	299-306
152604-3	1978	On the basis of the activity comparison of the Mg2+- and Ca2+-activated ATP-ase of the membrane fraction of the tetracycline sensitive and resistance strains of E. coli it was concluded that the resistance development in the strains tested to tetracycline was not associated with the changes in the ATP-ase activity.	tet	243-255	ATPase	Escherichia coli	72-79
152604-3	1978	On the basis of the activity comparison of the Mg2+- and Ca2+-activated ATP-ase of the membrane fraction of the tetracycline sensitive and resistance strains of E. coli it was concluded that the resistance development in the strains tested to tetracycline was not associated with the changes in the ATP-ase activity.	tet	243-255	ATPase	Escherichia coli	299-306
206470-0	1978	Effect of prolactin on tetracycline binding to human spermatozoa.	tet	23-35	prolactin	Homo sapiens	10-19
206470-1	1978	The effect of different concentrations of prolactin (0 to 60 ng) on the release of tetracycline from human spermatozoa labeled with 7-3H-tetracycline hydrochloride was studied.	tet	83-95	prolactin	Homo sapiens	42-51
206470-2	1978	Prolactin significantly enhanced the release of bound tetracycline, indicating that prolactin may influence the processes associated with sperm capacitation.	tet	54-66	prolactin	Homo sapiens	0-9
206470-2	1978	Prolactin significantly enhanced the release of bound tetracycline, indicating that prolactin may influence the processes associated with sperm capacitation.	tet	54-66	prolactin	Homo sapiens	84-93
72949-5	1977	epidemiologically linked with West Africa are more susceptible to tetracycline, require arginine for growth, and their gene coding for beta-lactamase synthesis is contained in a smaller 3-2 X 10(6) dalton plasmid.	tet	66-78	beta-lactamase	Neisseria gonorrhoeae	135-149
404460-0	1977	[Suppression of pancreatic lipase activity by 8-oxyquinolin and tetracycline derivatives in acute pancreatitis].	tet	64-76	pancreatic lipase	Homo sapiens	16-33
375027-2	1979	Tra+ derivatives of R100-1 carrying tetracycline resistance alone and those carrying all six drug-resistrance genes could support transfer of tra- point mutants of Flac except Flac traJ, whereas all of tra- derivatives of R100-1 failed to complement any one of tra- point mutants of Flac.	tet	36-48	T cell receptor alpha locus	Homo sapiens	0-3
375027-3	1979	This suggests that these tra- derivatives of R100-1 carrying tetracycline resistance gene are deleted for all the transfer genes impaired in the Flac point mutants tested.	tet	61-73	T cell receptor alpha locus	Homo sapiens	25-28
375027-6	1979	Complementation analysis of tra- derivatives carrying five resistance genes except the tetracycline gene led us to a supposition that a gene(s), probably analogous to traJ of the F plasmid, is located on R100-1 near the tetracycline gene which plays an important regulatory role for self-transfer as well as for the complementation of tra- Flac mutants.	tet	87-99	T cell receptor alpha locus	Homo sapiens	28-31
375027-6	1979	Complementation analysis of tra- derivatives carrying five resistance genes except the tetracycline gene led us to a supposition that a gene(s), probably analogous to traJ of the F plasmid, is located on R100-1 near the tetracycline gene which plays an important regulatory role for self-transfer as well as for the complementation of tra- Flac mutants.	tet	220-232	T cell receptor alpha locus	Homo sapiens	28-31
30835-4	1978	The circular dichroism studies indicate that the calcium ion in these complexes is bound to the C-4 dimethylamino and the C-12a hydroxyl groups of tetracycline.	tet	147-159	complement C4A (Rodgers blood group)	Homo sapiens	96-99
29219-3	1978	Multiply resistant Type 19A strains, resistant to beta-lactam antibiotics, erythromycin, clindamycin, tetracycline and chloramphenicol, were isolated from 128 carriers, and were responsible for bacteremia in four patients.	tet	102-114	SLAM family member 7	Homo sapiens	24-27
624295-2	1978	This drug is a semisynthetic tetracycline which has proven to pass into the CSF more effectively and to have a greater lipoid solubility than the other antibiotics of the same group.	tet	29-41	colony stimulating factor 2	Homo sapiens	76-79
713872-6	1978	Sm) (Tc, tetracycline; Sm, streptomycin) resistance mediate the formation of this type of DHPS.	tet	9-21	dihydropteroate synthetase	Escherichia coli	90-94
1099070-1	1975	The R factor NR1 consists of two components: a resistance transfer factor which harbors the tetracycline resistance genes (RTF-TC) and the r-determinants component which harbors the other drug resistance genes.	tet	92-104	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	13-16
1046356-2	1976	By repeatedly transducing from this strain, a strain (TP-2) having stable resistance to TC and PC could be obtained.	tet	88-90	transition protein 2	Homo sapiens	54-58
1046356-3	1976	In transformation with the deoxyribonucleic acid (DNA) of TP-2 as donor, all of the transformants obtained by selecting with either TC or PC were both TC and PC resistant.	tet	132-134	transition protein 2	Homo sapiens	58-62
1046356-3	1976	In transformation with the deoxyribonucleic acid (DNA) of TP-2 as donor, all of the transformants obtained by selecting with either TC or PC were both TC and PC resistant.	tet	151-153	transition protein 2	Homo sapiens	58-62
1046356-5	1976	The plasmid (P(TP-2)) is presumed to be a new plasmid in which the PC resistance gene was integrated into the TC-resistant plasmid.	tet	110-112	transition protein 2	Homo sapiens	15-19
1023818-2	1976	Observation of a group of patients with acute gastro-intestinal infections caused by NAG-vibrio and carriers of NAG-vibrioes showed that the rate of vibrio isolation after a course of antibiotic therapy (tetracycline, levomycetin) significantly decreased as compared to that in the group of the patients subjected only to symptomatic therapy.	tet	204-216	NBAS subunit of NRZ tethering complex	Homo sapiens	112-115
769862-1	1975	Stable L-forms were for the first time obtained under the effect of tetracycline on the Mec thnikov vibrio and NAG vibrio.	tet	68-80	C-C motif chemokine ligand 28	Homo sapiens	88-91
168821-4	1975	The accumulation of cyclic AMP after 5 minutes incubation with 0.15 muM norepinephrine plus adenosine deaminase was inhibited by 0.05 mg/ml of tetracycline.	tet	143-155	adenosine deaminase	Rattus norvegicus	92-111
239156-0	1975	The effect of mucin on the bioavailability of tetracycline from the gastrointestinal tract; in vivo, in vitro correlations.	tet	46-58	solute carrier family 13 member 2	Rattus norvegicus	14-19
239156-2	1975	In the presence of the mucin preparation an approximate 50% reduction in the numerical values of each of the parameters used to measure the tetracycline movement across the membrane was found.	tet	140-152	solute carrier family 13 member 2	Rattus norvegicus	23-28
239156-4	1975	Interaction of tetracycline with the porcine gastric mucin preparation is considered in relation to the molecular structure of mucus.	tet	15-27	solute carrier family 13 member 2	Rattus norvegicus	53-58
1119793-4	1975	The use of tetracycline in experimental staphylococcal sepsis was accompanied by an increase in the complement titer, lysozyme content and bactericidal properties of the serum after both the 1st and 2nd cycles of the drug administration.	tet	11-23	lysozyme C-like	Oryctolagus cuniculus	118-126
239124-0	1975	The influence of mucin on the bioavailability of tetracycline.	tet	49-61	LOC100508689	Homo sapiens	17-22
5497638-0	1970	[Effect of tetracycline on the content of lysozyme in the blood serum of rabbits and in human saliva].	tet	11-23	lysozyme C-like	Oryctolagus cuniculus	42-50
4156744-0	1974	Proceedings: Effect of mucin on the bioavailability of tetracycline from the gastro-intestinal tract: in vivo, in vitro correlations.	tet	55-67	LOC100508689	Homo sapiens	23-28
4584801-1	1973	Transformation of R-factor RP4 specifying resistance to ampicillin, kanamycin, and tetracycline from Escherichia coli to Rhizobium trifolii is reported.	tet	83-95	rhodopsin	Homo sapiens	27-30
4945186-3	1971	Delayed beta-galactosidase formation was found in relaxed auxotrophs recovering from amino acid starvation and in prototrophs recovering from chloramphenicol or from tetracycline treatment.	tet	166-178	galactosidase beta 1	Homo sapiens	8-26
4960882-0	1967	Sensitivity and resistance of TRIC agents to penicillin, tetracycline and sulfa drugs.	tet	57-69	MARVEL domain containing 2	Homo sapiens	30-34
5507400-0	1970	[Influence of tetracycline and ascorbic acid on the velocity of methemoglobin transformation in red blood cells suspended in vitro in a glucose and methylene blue medium].	tet	14-26	hemoglobin subunit gamma 2	Homo sapiens	64-77
5727410-0	1968	[Influence of lysozyme on intestinal absorption of tetracycline].	tet	51-63	lysozyme	Homo sapiens	14-22
4298603-0	1968	[Effect of some antibiotics on the transfer of the resistance to tetracycline and chloramphenicol by means of the episome factor (Rtf)].	tet	65-77	ATPase H+ transporting V0 subunit a2	Homo sapiens	130-133
14038453-0	1962	Effect of antibiotics of the tetracycline group on the activity of liver catalase.	tet	29-41	catalase	Homo sapiens	73-81
5976614-0	1966	Tetracycline hydrochloride in the treatment of cholera El Tor.	tet	0-26	RAR related orphan receptor C	Homo sapiens	58-61
5322786-0	1965	[Clinical experiments with a combination of antibiotics: tetracycline-chloramphenicol-lysozyme].	tet	57-69	lysozyme	Homo sapiens	86-94
13928515-0	1962	Tetracycline resistance in group A beta-haemolytic streptococci.	tet	0-12	amyloid beta precursor protein	Homo sapiens	33-39
33934773-5	2021	The limit of detections (LODs) for CP and TET were 3.02 and 3.52 ng mL-1, respectively while RSDs % were below than 4.0%.	tet	42-45	L1 cell adhesion molecule	Mus musculus	68-72
13915813-12	1962	1</protein-id> group but in only nine of the 19-BA group.Tetracycline treatment in all the Rev 1 group and in the two brucellosis cases in the 19-BA group resulted in complete recovery.The authors conclude from this study that neither the Rev 1 vaccine nor the 19-BA vaccine inoculated subcutaneously is sufficiently safe in the dosage used to warrant being used for vaccination of humans for prophylactic purposes.	tet	57-69	REV1 DNA directed polymerase	Homo sapiens	91-96
13915813-12	1962	1</protein-id> group but in only nine of the 19-BA group.Tetracycline treatment in all the Rev 1 group and in the two brucellosis cases in the 19-BA group resulted in complete recovery.The authors conclude from this study that neither the Rev 1 vaccine nor the 19-BA vaccine inoculated subcutaneously is sufficiently safe in the dosage used to warrant being used for vaccination of humans for prophylactic purposes.	tet	57-69	REV1 DNA directed polymerase	Homo sapiens	239-244
13754942-0	1960	Tetracycline resistance of group A beta hemolytic streptococci.	tet	0-12	amyloid beta precursor protein	Homo sapiens	33-39
33784555-9	2021	With the addition of coagulant aid anion polyacrylamide, the TC removal remained unchanged, effluent turbidity significantly reduced, and the TC desorption became low.	tet	61-63	activation induced cytidine deaminase	Homo sapiens	31-34
33784555-9	2021	With the addition of coagulant aid anion polyacrylamide, the TC removal remained unchanged, effluent turbidity significantly reduced, and the TC desorption became low.	tet	142-144	activation induced cytidine deaminase	Homo sapiens	31-34
33545591-6	2021	The results from the photocatalytic experiments showed that the degradation efficiency of TC by P-CoFe2O4@GCN-1 could reach 96.2% within 60 min, which is 3.19 times higher than that of GCN.	tet	90-92	GCN1 activator of EIF2AK4	Homo sapiens	106-111
33548649-2	2021	Here, we report the facile fabrication of porous hollow Ag/Ag2S/Ag3PO4 heterostrucutres for efficient photocatalytic degradation of tetracycline under simulated sunlight irradiation.	tet	132-144	angiotensin II receptor type 1	Homo sapiens	59-63
33881296-7	2021	Under optimal conditions, the fluorescent signal increased with the increasing target TET concentration within the 5 orders of magnitude dynamic range from 0.001 to 10 ng mL-1.	tet	86-89	L1 cell adhesion molecule	Mus musculus	171-175
34016127-5	2021	Detection of tetracycline and ciprofloxacin determinants was done by amplification of tetO gene and PCR-sequencing of the gyrA gene.	tet	13-25	tetO	Campylobacter coli	86-90
34016127-10	2021	All of the 17 phenotypically tetracycline-resistant Campylobacter isolates harbored the tetO gene.	tet	29-41	tetO	Campylobacter coli	88-92
33619758-3	2021	Here, we address the role of tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.	tet	29-41	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	103-108
33619758-5	2021	Stronger inhibition by tetracycline is verified with nonequilibrium PMF calculations, for which the tetracycline-RBD complex exhibits the lowest free energy profile along the dissociation pathway from ACE2.	tet	23-35	angiotensin converting enzyme 2	Homo sapiens	201-205
33619758-5	2021	Stronger inhibition by tetracycline is verified with nonequilibrium PMF calculations, for which the tetracycline-RBD complex exhibits the lowest free energy profile along the dissociation pathway from ACE2.	tet	100-112	angiotensin converting enzyme 2	Homo sapiens	201-205
33881296-8	2021	The detection limit was calculated to be 0.724 pg mL-1 and the method showed high selectivity toward TET among different antibiotics.	tet	101-104	L1 cell adhesion molecule	Mus musculus	50-54
33429261-5	2021	The resultant Bi2S3@Ag2S/CC composite films exhibit excellent photothermal conversion performance and photocatalytic degradation activity for tetracycline hydrochloride in low temperature wastewater under simulated sunlight.	tet	142-168	angiotensin II receptor type 1	Homo sapiens	20-24
33847168-10	2021	In particular, the 1% and 3% TCN patch groups exhibited significant muscle layer regeneration by desmin immunostaining.	tet	29-32	desmin	Rattus norvegicus	97-103
33847168-11	2021	Further histological and immunofluorescence analyses revealed that the 1% and 3% TCN patch groups exhibited the best esophageal regeneration according to re-epithelialization, neovascularization and elastin texture around the implanted sites.	tet	81-84	elastin	Rattus norvegicus	199-206
33541637-1	2021	This study demonstrated a drug-delivery system with anionic beta cyclodextrin (beta-CD) complexes to retain tetracycline (TC) and control its release from multilayers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL) in a ten double layers ([PAA/PLL]10) coating onto titanium.	tet	108-120	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	79-86
33541637-1	2021	This study demonstrated a drug-delivery system with anionic beta cyclodextrin (beta-CD) complexes to retain tetracycline (TC) and control its release from multilayers of poly(acrylic acid) (PAA) and poly(l-lysine) (PLL) in a ten double layers ([PAA/PLL]10) coating onto titanium.	tet	122-124	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	79-86
33541637-5	2021	Remarkably, [PAA/PLL]10/TC/anionic beta-CD antibacterial effect was sustained even after 30 days of incubation.	tet	24-26	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	35-42
33635515-7	2021	The tested substances demonstrated effectiveness at decreasing the MIC of erythromycin, tetracycline and ethidium bromide, potentially by inhibiting the MsrA macrolide and the TetK tetracycline efflux pumps present in the tested S. aureus strains.	tet	88-100	ABC transporter permease protein	Staphylococcus aureus	153-157
33539834-0	2021	Synergistic impacts of Cu2+ on simultaneous removal of tetracycline and tetracycline resistance genes by PSF/TPU/UiO forward osmosis membrane.	tet	55-67	splicing factor proline and glutamine rich	Homo sapiens	105-108
33539834-0	2021	Synergistic impacts of Cu2+ on simultaneous removal of tetracycline and tetracycline resistance genes by PSF/TPU/UiO forward osmosis membrane.	tet	72-84	splicing factor proline and glutamine rich	Homo sapiens	105-108
33831705-3	2021	In this work, bovine serum albumin-capped gold nanoclusters (BSA-AuNCs) were ingeniously used as the ratiometric fluorescent probe for detecting DC over other tetracycline antibiotics through the selective sensitization effect of BSA on DC.	tet	159-171	albumin	Homo sapiens	21-34
32520982-11	2021	We established HEK293 stable cell lines of WT, nbl-type, and DCM-type HSPD1, with tetracycline-dependent expression.	tet	82-94	heat shock protein family D (Hsp60) member 1	Homo sapiens	70-75
33841427-5	2021	To study the contribution of proinsulin-1 reactive T cells in autoimmune diabetes, we generated transgenic NOD mice with tetracycline-regulated expression of proinsulin-1 in antigen presenting cells (TIP-1 mice) with an aim to induce immune tolerance.	tet	121-133	Tax1 (human T cell leukemia virus type I) binding protein 3	Mus musculus	200-205
33850974-5	2021	Raman spectroscopy is an analytical tool ideally suited for the determination of bone compositional / material properties as a function of tissue age as it is capable of analyzing areas ~1 x 1 mum2 in tetracycline labeled bone forming areas.	tet	201-213	trafficking protein particle complex subunit 1	Homo sapiens	193-197
33285524-3	2021	The obtained Au3@Ag1/GO (molar ratio of Au to Ag~3:1) with improved synergistic effects provides a remarkable higher visible-light (>400nm) photocatalytic activity for a complete degradation (99.36%) of tetracycline hydrochloride (TCH) molecules within 70 min, while about 61.74% or 62.38% via monometallic Au/GO or Ag/GO.	tet	203-229	thioredoxin domain containing 12	Homo sapiens	17-20
33285524-3	2021	The obtained Au3@Ag1/GO (molar ratio of Au to Ag~3:1) with improved synergistic effects provides a remarkable higher visible-light (>400nm) photocatalytic activity for a complete degradation (99.36%) of tetracycline hydrochloride (TCH) molecules within 70 min, while about 61.74% or 62.38% via monometallic Au/GO or Ag/GO.	tet	231-234	thioredoxin domain containing 12	Homo sapiens	17-20
33497365-4	2021	We developed a transgenic mouse model for tetracycline-inducible and heart-specific expression of human DMPK mRNA containing 960 CUG repeats.	tet	42-54	DM1 protein kinase	Homo sapiens	104-108
33704065-4	2021	tTARGIT AAVs utilize a Flp-dependent tetracycline transactivator (tTA) "Driver" AAV and a tetracycline response element (TRE)-driven, Cre-dependent "Payload" AAV to express the transgene of interest.	tet	37-49	4-hydroxyphenylpyruvic acid dioxygenase	Mus musculus	23-26
33627480-0	2021	Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.	tet	18-30	Eph receptor B1	Mus musculus	47-52
33627480-3	2021	An in silico screen was first used to identify a number of tetracycline antibiotics which demonstrated potential docking to the ATP-binding catalytic domain of EphB1.	tet	59-71	Eph receptor B1	Mus musculus	160-165
33627480-6	2021	Finally, in vivo administration of the three-tetracycline combination inhibited the phosphorylation of EphB1 in the brain, spinal cord, and dorsal root ganglion (DRG) and effectively blocked neuropathic pain in mice.	tet	45-57	Eph receptor B1	Mus musculus	103-108
33756271-2	2021	We have previously shown by using a tetracycline-inducible Ctcfl transgene that inappropriate expression of Ctcfl negatively impacts fetal development and causes early postnatal lethality in the mouse.	tet	36-48	CCCTC-binding factor (zinc finger protein)-like	Mus musculus	59-64
33756271-2	2021	We have previously shown by using a tetracycline-inducible Ctcfl transgene that inappropriate expression of Ctcfl negatively impacts fetal development and causes early postnatal lethality in the mouse.	tet	36-48	CCCTC-binding factor (zinc finger protein)-like	Mus musculus	108-113
33719123-7	2021	The ESBL-positives showed significantly higher resistance rates to gentamicin, co-trimoxazole, tetracycline, aztreonam, and chloramphenicol (P<0.05).	tet	95-107	EsbL	Escherichia coli	4-8
33486887-1	2021	Using a validated tetracycline-off-inducible CD44 expression system in mouse model, we have previously demonstrated that the hyaluronan (HA) receptor CD44 promotes breast cancer (BC) metastasis to the liver.	tet	18-30	CD44 antigen	Mus musculus	45-49
33168454-5	2021	METHODS: In this study, the authors engineered ReNcell CX (EMD Millipore, Temecula, CA, USA) neural progenitor cells to express truncated GAS1 (tGAS1) under a tetracycline/on inducible system using lentiviral vectors.	tet	159-171	growth arrest specific 1	Homo sapiens	138-142
33168454-6	2021	RESULTS: Here the authors show that treatment with ReNcell-tGAS1 in combination with tetracycline decreased primary tumor growth and inhibited the formation of metastases in tumor-bearing mice by diminishing the phosphorylation of AKT and ERK1/2 in orthotopic mammary gland tumors.	tet	85-97	thymoma viral proto-oncogene 1	Mus musculus	231-234
33168454-6	2021	RESULTS: Here the authors show that treatment with ReNcell-tGAS1 in combination with tetracycline decreased primary tumor growth and inhibited the formation of metastases in tumor-bearing mice by diminishing the phosphorylation of AKT and ERK1/2 in orthotopic mammary gland tumors.	tet	85-97	mitogen-activated protein kinase 3	Mus musculus	239-245
33486887-1	2021	Using a validated tetracycline-off-inducible CD44 expression system in mouse model, we have previously demonstrated that the hyaluronan (HA) receptor CD44 promotes breast cancer (BC) metastasis to the liver.	tet	18-30	CD44 antigen	Mus musculus	150-154
33486887-2	2021	To unravel the mechanisms that underpin CD44-promoted BC cell invasion, RNA samples were isolated from two cell models: (a) a tetracycline (Tet)-Off-regulated expression system of the CD44s in MCF-7 cells and; (b) as a complementary approach, the highly metastatic BC cells, MDA-MB-231, were cultured in the presence and absence of 50 microg/mL of HA.	tet	140-143	CD44 molecule (Indian blood group)	Homo sapiens	184-188
33626352-3	2021	Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation.	tet	37-49	fibroblast growth factor 10	Mus musculus	81-108
33718734-5	2021	The photodegradation rate of TC over the 0.6% PtO-ZnO nanocomposite is 34 and 12.5 times greater than that of pristine ZnO and commercial P-25, respectively.	tet	29-31	tubulin polymerization promoting protein	Homo sapiens	138-142
33626352-3	2021	Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation.	tet	37-49	fibroblast growth factor 10	Mus musculus	110-115
33626352-3	2021	Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation.	tet	51-54	fibroblast growth factor 10	Mus musculus	81-108
33626352-3	2021	Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation.	tet	51-54	fibroblast growth factor 10	Mus musculus	110-115
33394314-5	2021	By crossing with VegftetO/tetO mice, that has tetracycline operator sequences insertion in 5"-UTR region, it allows us to reversibly inhibit lung VEGF transcription from its endogenous level through doxycycline food, water or injection.	tet	46-58	vascular endothelial growth factor A	Mus musculus	146-150
33669325-9	2021	Furthermore, RT-126 isolates were positive for tetracycline resistance determinants, confirming that tetracycline resistance is widespread among ST11 isolates from cattle.	tet	101-113	Pancreatic endocrine tumor suppressor	Homo sapiens	145-149
33247717-7	2021	The cloned tet(63) gene was functionally expressed in S. aureus and shown to confer resistance to tetracycline and doxycycline, and a slightly elevated MIC of minocycline.	tet	98-110	tetracycline-resistance protein	Staphylococcus aureus	11-14
33247717-10	2021	The deduced amino acid sequence of the Tet(63) protein exhibited 73.0% identity to the tetracycline efflux protein Tet(K).	tet	87-99	tetracycline-resistance protein	Staphylococcus aureus	39-42
33247717-10	2021	The deduced amino acid sequence of the Tet(63) protein exhibited 73.0% identity to the tetracycline efflux protein Tet(K).	tet	87-99	tetracycline-resistance protein	Staphylococcus aureus	115-118
33360083-6	2021	O2- /HO2  and  OH were responsible for the cathodic TC degradation.	tet	52-54	heme oxygenase 2	Homo sapiens	5-8
33310237-8	2021	Tetracycline resistance gene (TRG) enrichment was 15.86% higher in the biofilm that experienced short-term OTC shock than in the control biofilm in the continuous-flow SPD system.	tet	0-12	T cell receptor gamma locus	Homo sapiens	30-33
33226591-12	2021	Utilizing transgenic technology based on the Tetracycline-controlled system, we have established inducible transgenic mouse models in which cytokine IL-22 can be expressed specifically in the lung or skin.	tet	45-57	interleukin 22	Mus musculus	149-154
34019298-0	2021	Generation of a Tetracycline Regulated Mouse Model of MYC-Induced T-Cell Acute Lymphoblastic Leukemia.	tet	16-28	myelocytomatosis oncogene	Mus musculus	54-57
33509017-6	2021	Selective autophagy was inhibited as illustrated by the accumulation of large protein aggregates in BPLF1-positive cells co-transfected with an aggregate-prone HTT (huntingtin)-Q109 construct, and by a slower autophagy-dependent clearance of protein aggregates upon transfection of BPLF1 in cells expressing a tetracycline-regulated HTT-Q103.	tet	310-322	huntingtin	Homo sapiens	165-175
33483615-3	2021	To address this, we developed a tetracycline-regulated mouse model of T-ALL driven by the oncogenic transcription factor Lmo2.	tet	32-44	LIM domain only 2	Mus musculus	121-125
32927176-4	2021	The 10% PCN/ZIS had the best photocatalytic degradation performance for tetracycline with a photodegradation rate of 0.0874 min-1, which is respectively about 2.9 and 52.0 times than that of pure ZIS and PCN.	tet	72-84	zinc finger RANBP2-type containing 2	Homo sapiens	12-15
32927176-4	2021	The 10% PCN/ZIS had the best photocatalytic degradation performance for tetracycline with a photodegradation rate of 0.0874 min-1, which is respectively about 2.9 and 52.0 times than that of pure ZIS and PCN.	tet	72-84	zinc finger RANBP2-type containing 2	Homo sapiens	196-199
33373204-10	2021	In addition, porous ZIF-8/PAN fibers could act as the membrane adsorbents to dynamically separate tetracycline with a treated capacity of 9.93 x 103 bed volumes.	tet	98-110	adenosine deaminase 2	Homo sapiens	20-29
33413507-3	2021	We hypothesized that the tetracycline-controlled gene expression/suppression system could be applied to develop global GAD67 knockdown mice that would survive into adulthood.	tet	25-37	glutamate decarboxylase 1	Homo sapiens	119-124
33096433-0	2021	A broad-spectrum sensing strategy for the tetracycline family of antibiotics based on an ovalbumin-stabilized gold nanocluster and its application in a pump-free microfluidic sensing platform.	tet	42-54	ovalbumin (SERPINB14)	Gallus gallus	89-98
33096433-3	2021	The OVA-stabilized AuNCs (AuNCs@OVA) manifest intriguing multicolour fluorescence and a gradually declining fluorescence intensity at 650 nm with an increasing concentration of tetracycline family antibiotics (TCs) including tetracycline, chlorotetracycline, oxytetracycline, and doxycycline, which are a widely used class of antibiotics for treating infections in food-producing animals.	tet	177-189	ovalbumin (SERPINB14)	Gallus gallus	4-7
33226591-3	2021	We aimed to develop mouse models of allergic diseases in the lung and skin with inducible and tissue-specific expression of IL-22, using a tetracycline (Tet)-controlled system.	tet	139-151	interleukin 22	Mus musculus	124-129
33226591-3	2021	We aimed to develop mouse models of allergic diseases in the lung and skin with inducible and tissue-specific expression of IL-22, using a tetracycline (Tet)-controlled system.	tet	153-156	interleukin 22	Mus musculus	124-129
33462515-6	2021	We subsequently show that a sub-library of tetracycline analogues, including doxycycline, rescues cell death and inflammatory signatures in mutant cells through partial and selective inhibition of mitochondrial translation, resulting in an ATF4-independent mitohormetic response.	tet	43-55	activating transcription factor 4	Mus musculus	240-244
33403289-4	2020	Mesoporous 1.5% Ag2O-ZnO nanocomposites indicated the highest degradation efficiency of 100% of TC during 120 min of the visible light exposure compared with 5% and 10% for pristine ZnO NPs and commercial P-25, respectively.	tet	96-98	tubulin polymerization promoting protein	Homo sapiens	205-209
33403289-5	2020	The TC degradation rate took place much rapidly over 1.5% Ag2O-ZnO nanocomposites (0.798 mumol L-1 min-1) as compared to either commercial P-25 (0.097 mumol L-1 min-1) or ZnO NPs (0.035 mumol L-1 min-1).	tet	4-6	tubulin polymerization promoting protein	Homo sapiens	139-143
32777522-6	2020	We next placed mcl1-AS1 under tetracycline-inducible control and demonstrated decreased viability in HEK293 cells upon doxycycline induction.	tet	30-42	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	15-19
32777522-6	2020	We next placed mcl1-AS1 under tetracycline-inducible control and demonstrated decreased viability in HEK293 cells upon doxycycline induction.	tet	30-42	prostaglandin D2 receptor	Homo sapiens	20-23
33039597-9	2020	The strain was identified as S. Typhimuirium ST19 harboring a 265.5 kbp pN1566-2 plasmid carryingthe genes encoding for resistance against colistin (mcr-9.1), aminoglycoside (aadA1), tetracycline (tet(C)), and sulfonamide (sul1).	tet	183-195	cyclin dependent kinase 2 associated protein 1	Homo sapiens	45-49
33537535-5	2021	Methods: To avoid off-target effects, we generated iPSCs carrying the reverse tetracycline-responsive transactivator M2 (rtTA-M2) in the Rosa26 locus and expressed the factors from Tet-inducible gammaretroviral vectors.	tet	78-90	gene trap ROSA 26, Philippe Soriano	Mus musculus	137-143
32894817-9	2020	Because IRX4 is a sequence-specific transcription factor, downstream molecules of IRX4 were pursued by microarray analyses utilizing tetracycline-mediated IRX4 inducible PK-1 and PK-9 cells; CRYAB, CD69, and IL32 were identified as IRX4-downstream candidate genes.	tet	133-145	iroquois homeobox 4	Homo sapiens	8-12
32894817-9	2020	Because IRX4 is a sequence-specific transcription factor, downstream molecules of IRX4 were pursued by microarray analyses utilizing tetracycline-mediated IRX4 inducible PK-1 and PK-9 cells; CRYAB, CD69, and IL32 were identified as IRX4-downstream candidate genes.	tet	133-145	iroquois homeobox 4	Homo sapiens	82-86
32894817-9	2020	Because IRX4 is a sequence-specific transcription factor, downstream molecules of IRX4 were pursued by microarray analyses utilizing tetracycline-mediated IRX4 inducible PK-1 and PK-9 cells; CRYAB, CD69, and IL32 were identified as IRX4-downstream candidate genes.	tet	133-145	iroquois homeobox 4	Homo sapiens	82-86
32894817-9	2020	Because IRX4 is a sequence-specific transcription factor, downstream molecules of IRX4 were pursued by microarray analyses utilizing tetracycline-mediated IRX4 inducible PK-1 and PK-9 cells; CRYAB, CD69, and IL32 were identified as IRX4-downstream candidate genes.	tet	133-145	prokineticin 1	Homo sapiens	170-174
32894817-9	2020	Because IRX4 is a sequence-specific transcription factor, downstream molecules of IRX4 were pursued by microarray analyses utilizing tetracycline-mediated IRX4 inducible PK-1 and PK-9 cells; CRYAB, CD69, and IL32 were identified as IRX4-downstream candidate genes.	tet	133-145	interleukin 32	Homo sapiens	208-212
32894817-9	2020	Because IRX4 is a sequence-specific transcription factor, downstream molecules of IRX4 were pursued by microarray analyses utilizing tetracycline-mediated IRX4 inducible PK-1 and PK-9 cells; CRYAB, CD69, and IL32 were identified as IRX4-downstream candidate genes.	tet	133-145	iroquois homeobox 4	Homo sapiens	82-86
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	tet	0-12	jun proto-oncogene	Mus musculus	175-179
33244162-8	2020	We modulated the activity using (1) an active site mutant (E219Q) of MMP1, (2) MMP9, another member of the MMP family that increases the activity of MMP1, and (3) tetracycline, an inhibitor of MMP1.	tet	163-175	matrix metallopeptidase 1	Homo sapiens	69-72
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	tet	0-12	BTB and CNC homology, basic leucine zipper transcription factor 2	Mus musculus	23-28
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	tet	0-12	BTB and CNC homology, basic leucine zipper transcription factor 2	Mus musculus	169-174
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	tet	0-12	interferon gamma	Mus musculus	212-216
32748675-2	2020	This study aimed to evaluate the effects of chronic lipopolysaccharide (LPS) injected alone or together with tetracycline antibiotic doxycycline (Dox) on the levels of Iba-1, BDNF, Bcl-xL and MMP-9 in brain regions in relation to stress-induced behaviors in the elevated plus-maze (EPM).	tet	109-121	allograft inflammatory factor 1	Rattus norvegicus	168-173
32979461-0	2020	Evolution of IS26-bounded pseudo-compound transposons carrying the tet(C) tetracycline resistance determinant.	tet	74-86	TnpA	Escherichia coli	13-17
33150175-3	2020	Toxicity experiments showed that TCs had significant inhibition on CAT in the sequence of tetracycline>chlortetracycline>oxytetracycline>doxycycline.	tet	90-102	catalase	Homo sapiens	67-70
33096790-6	2020	Methods: Here, we developed mice with tetracycline-inducible lung-specific expression of the full-length genomic DNA of the human epidermal growth factor receptor containing an L858R mutation or both L858R and T790M mutations and evaluated de novo T790M mutation in untreated transgenic mice carrying a single L858R EGFR mutation.	tet	38-50	epidermal growth factor receptor	Homo sapiens	130-162
33096790-6	2020	Methods: Here, we developed mice with tetracycline-inducible lung-specific expression of the full-length genomic DNA of the human epidermal growth factor receptor containing an L858R mutation or both L858R and T790M mutations and evaluated de novo T790M mutation in untreated transgenic mice carrying a single L858R EGFR mutation.	tet	38-50	epidermal growth factor receptor	Mus musculus	316-320
32926033-3	2020	CSN5 showed the best photodegradation activity for TC degradation (100 mL, 20 mg L-1; 100% degradation in 60 min; lambda >= 420 nm) and the highest H2 evolution rate of 1275.42 mumol h-1 g-1 was approximately 3.73- and 32.25-times higher than those of pristine g-C3N4 (341.85 mumol h-1 g-1) and pure CeO2 (39.55 mumol h-1 g-1), respectively.	tet	51-53	COP9 signalosome subunit 5	Homo sapiens	0-4
32948209-3	2020	We generated a transgenic mouse in which the expression of HCN4 can be reversibly knocked down using a genetic tetracycline-dependent switch and conducted genetically validated immunohistochemistry for HCN4.	tet	111-123	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	Mus musculus	59-63
32613509-2	2020	Especially when the mass ratio of Ag3PO4 was 20% of MIL-100(Fe) (APM-2), it displayed the best photocatalytic performance, for which the degradation rate of tetracycline (TC) in conventional environment was 6.8 times higher than that of bare MIL-100(Fe).	tet	157-169	adipogenesis regulatory factor	Homo sapiens	65-70
32613509-2	2020	Especially when the mass ratio of Ag3PO4 was 20% of MIL-100(Fe) (APM-2), it displayed the best photocatalytic performance, for which the degradation rate of tetracycline (TC) in conventional environment was 6.8 times higher than that of bare MIL-100(Fe).	tet	171-173	adipogenesis regulatory factor	Homo sapiens	65-70
32947653-6	2021	We used the CysF-STOP-tetO::Iba-mtTA mouse model, in which cystatin F gene expression is driven by the tetracycline operator.	tet	103-115	cystatin F (leukocystatin)	Mus musculus	59-69
32977759-15	2020	All the isolates expressing TetM were tetracycline resistant (MIC> 1 mg/L) and had increased doxycycline MICs (up to 96 mg/L).	tet	38-50	TetM	Neisseria gonorrhoeae	28-32
32977759-18	2020	CONCLUSION: High-level gonococcal penicillin and tetracycline resistance in the sampled Kenyan regions was found to be mediated by plasmid borne blaTEM and tetM genes.	tet	49-61	TetM	Neisseria gonorrhoeae	156-160
32932729-0	2020	Preparation of a g-C3N4/UiO-66-NH2/CdS Photocatalyst with Enhanced Visible Light Photocatalytic Activity for Tetracycline Degradation.	tet	109-121	CDP-diacylglycerol synthase 1	Homo sapiens	35-38
32942535-5	2020	Using H1299 cells, which are null for TP53, we generated cell lines expressing either a tetracycline inducible wild-type (WT) TP53 gene, or a representative mutated TP53 gene from six exemplary "hotspot" mutations in the DNA binding domain (R273H, R248Q, R282W, R175H, G245S, and R249S).	tet	88-100	tumor protein p53	Homo sapiens	126-130
32942535-5	2020	Using H1299 cells, which are null for TP53, we generated cell lines expressing either a tetracycline inducible wild-type (WT) TP53 gene, or a representative mutated TP53 gene from six exemplary "hotspot" mutations in the DNA binding domain (R273H, R248Q, R282W, R175H, G245S, and R249S).	tet	88-100	tumor protein p53	Homo sapiens	126-130
32932729-1	2020	A combination of calcination and hydrothermal processing was used to prepare a g-C3N4/UiO-66-NH2/CdS photocatalyst, and the degradation of tetracycline (TC) over this material was assessed.	tet	139-151	CDP-diacylglycerol synthase 1	Homo sapiens	97-100
32932729-1	2020	A combination of calcination and hydrothermal processing was used to prepare a g-C3N4/UiO-66-NH2/CdS photocatalyst, and the degradation of tetracycline (TC) over this material was assessed.	tet	153-155	CDP-diacylglycerol synthase 1	Homo sapiens	97-100
32932729-2	2020	The photocatalytic performance of this nanocomposite was approximately 4.4 and 2.3 times those of CdS and g-C3N4, respectively, and was found to be affected by the CdS loading amount, the pH of the reaction solution and the initial TC concentration.	tet	232-234	CDP-diacylglycerol synthase 1	Homo sapiens	164-167
32675303-5	2020	METHODS: We generated tetracycline-inducible APOL1 expression in human embryonic kidney HEK293 cells and examined the effects of increased expression of APOL1 (G0, G1, G2, G0G0, G0G1, or G0G2) on known cytotoxicity phenotypes, including reduced viability, increased swelling, potassium loss, aberrant protein phosphorylation, and dysregulated energy metabolism.	tet	22-34	apolipoprotein L1	Homo sapiens	45-50
32707597-3	2020	Tetracycline-inducible MAMDC2 expression system was established and used to evaluate cell proliferation in vitro and in vivo.	tet	0-12	MAM domain containing 2	Homo sapiens	23-29
32513897-3	2020	Here we show that bacterial plasmid mucAB and its Escherichia coli genomic homolog umuDC, carrying homologies that match the mouse anti-miR-145, sequestered the miR-145 function in mouse BALB 3T3 cells in a tetracycline (Tet)-inducible manner, activated oncogene Nedd9 and its downstream Aurkb.	tet	207-219	microRNA 145a	Mus musculus	161-168
32513897-3	2020	Here we show that bacterial plasmid mucAB and its Escherichia coli genomic homolog umuDC, carrying homologies that match the mouse anti-miR-145, sequestered the miR-145 function in mouse BALB 3T3 cells in a tetracycline (Tet)-inducible manner, activated oncogene Nedd9 and its downstream Aurkb.	tet	207-219	neural precursor cell expressed, developmentally down-regulated gene 9	Mus musculus	263-268
32513897-3	2020	Here we show that bacterial plasmid mucAB and its Escherichia coli genomic homolog umuDC, carrying homologies that match the mouse anti-miR-145, sequestered the miR-145 function in mouse BALB 3T3 cells in a tetracycline (Tet)-inducible manner, activated oncogene Nedd9 and its downstream Aurkb.	tet	207-219	aurora kinase B	Mus musculus	288-293
32513897-3	2020	Here we show that bacterial plasmid mucAB and its Escherichia coli genomic homolog umuDC, carrying homologies that match the mouse anti-miR-145, sequestered the miR-145 function in mouse BALB 3T3 cells in a tetracycline (Tet)-inducible manner, activated oncogene Nedd9 and its downstream Aurkb.	tet	221-224	microRNA 145a	Mus musculus	161-168
32513897-3	2020	Here we show that bacterial plasmid mucAB and its Escherichia coli genomic homolog umuDC, carrying homologies that match the mouse anti-miR-145, sequestered the miR-145 function in mouse BALB 3T3 cells in a tetracycline (Tet)-inducible manner, activated oncogene Nedd9 and its downstream Aurkb.	tet	221-224	neural precursor cell expressed, developmentally down-regulated gene 9	Mus musculus	263-268
32513897-3	2020	Here we show that bacterial plasmid mucAB and its Escherichia coli genomic homolog umuDC, carrying homologies that match the mouse anti-miR-145, sequestered the miR-145 function in mouse BALB 3T3 cells in a tetracycline (Tet)-inducible manner, activated oncogene Nedd9 and its downstream Aurkb.	tet	221-224	aurora kinase B	Mus musculus	288-293
32746815-7	2020	CONCLUSIONS: Considering the results, tetA is the most common tetracycline resistance gene, and the presence of tetD and antibiotic sensitivity to tetracycline had a significant relationship in E. coli isolated from colibacillosis infections.	tet	62-74	regulatory helix-turn-helix protein TetD	Escherichia coli	112-116
32818796-8	2020	As an artificial system, we utilized HEK293 cells, overexpressing Nox4 in a tetracycline-inducible manner.	tet	76-88	NADPH oxidase 4	Homo sapiens	66-70
32629178-3	2020	To study resistance to BRAF inhibition, we developed a novel mouse model of melanoma using a tetracycline/doxycycline-regulated system that permits control of mutant BRAF expression.	tet	93-105	Braf transforming gene	Mus musculus	166-170
32746815-7	2020	CONCLUSIONS: Considering the results, tetA is the most common tetracycline resistance gene, and the presence of tetD and antibiotic sensitivity to tetracycline had a significant relationship in E. coli isolated from colibacillosis infections.	tet	147-159	regulatory helix-turn-helix protein TetD	Escherichia coli	112-116
32097812-3	2020	The removal percentages for SMX and TC were 99.70-100% and 99.66-99.85% at HRT of 1 d, respectively, in MFC-CWs with plant and circuit connection when the influent SMX and TC concentrations were 5-100 mug L-1 and 5-50 mug L-1.	tet	36-38	immunoglobulin kappa variable 1-16	Homo sapiens	205-208
32475391-6	2020	The limit of detection and limit of quantification for TET were found to be 6 pg mL-1 and 20 pg mL-1, respectively.	tet	55-58	L1 cell adhesion molecule	Mus musculus	81-92
32330570-8	2020	Tetracycline derivatives acted as effective inhibitors to reverse the self-assembly of hIAPP and Abeta, and disaggregate the aged peptides fibrils into mostly monomers.	tet	0-12	islet amyloid polypeptide	Homo sapiens	87-92
32330570-8	2020	Tetracycline derivatives acted as effective inhibitors to reverse the self-assembly of hIAPP and Abeta, and disaggregate the aged peptides fibrils into mostly monomers.	tet	0-12	amyloid beta precursor protein	Homo sapiens	97-102
32330570-12	2020	This work provided a basis for using tetracycline antibiotics as potential inhibitors against hIAPP aggregation.	tet	37-49	islet amyloid polypeptide	Homo sapiens	94-99
32371051-3	2020	We have previously reported transgenic mice with neuronal expression of human TDP-43 carrying the pathogenic A315T mutation (iTDP-43A315T mice) using a tetracycline-controlled inducible promotor system.	tet	152-164	TAR DNA binding protein	Homo sapiens	78-84
32097812-3	2020	The removal percentages for SMX and TC were 99.70-100% and 99.66-99.85% at HRT of 1 d, respectively, in MFC-CWs with plant and circuit connection when the influent SMX and TC concentrations were 5-100 mug L-1 and 5-50 mug L-1.	tet	36-38	immunoglobulin kappa variable 1-16	Homo sapiens	222-225
32427483-7	2020	Here we present the utilization of the previously described tetracycline-dependent ribozyme K19 for controlling AAV-mediated transgene expression in mice.	tet	60-72	keratin 19	Mus musculus	92-95
32375304-3	2020	First, a tetracycline-bovine serum albumin conjugate coating was applied to a microplate.	tet	9-21	albumin	Homo sapiens	29-42
32105955-5	2020	As the formation of highly photochemical [ Fe(C2O4)3]3- complex ions on the surface of the (Mg,Ni)(Fe,Al)2O4, the obtained (Mg,Ni)(Fe,Al)2O4 showed degradation efficiency (eta) over 90.0 % for common organic dyes and antibiotic tetracycline within 180 min under the optimum conditions.	tet	228-240	endothelin receptor type A	Homo sapiens	172-175
32379807-6	2020	To this end, a tetracycline trigger plasmid was constructed by replacing the araC repressor gene and the ara operator of the arabinose trigger plasmid with the tetR gene coding for the tetracycline repressor and the tet operon.	tet	15-27	tetracycline resistance repressor protein TetR	Escherichia coli	160-164
32379807-6	2020	To this end, a tetracycline trigger plasmid was constructed by replacing the araC repressor gene and the ara operator of the arabinose trigger plasmid with the tetR gene coding for the tetracycline repressor and the tet operon.	tet	185-197	tetracycline resistance repressor protein TetR	Escherichia coli	160-164
32547121-18	2020	ESBL-producing Enterobacteriaceae showed higher resistance against tetracycline (91.1%) and cotrimoxazole (93.84%).	tet	67-79	EsbL	Escherichia coli	0-4
32244147-8	2020	Here, we characterize a Cre-activated, Doxycycline (Dox)-controlled, conditional CycD1 overexpression model, which when bred to a tetracycline-controlled transcriptional activator and the Atoh1-cre mouse lines, allow for transient CycD1 overexpression and pRBs" downregulation in the inner ear in a reversible fashion.	tet	130-142	cyclin D1	Mus musculus	81-86
32094405-5	2020	This assay demonstrates that DR1/PMMA is able to capture either tetracycline or ampicillin and the relative amount of DR1/PMMA required for capture was determined.	tet	64-76	down-regulator of transcription 1	Homo sapiens	29-32
31848088-0	2020	Bio-inspired, high, and fast adsorption of tetracycline from aqueous media using Fe3O4-g-CN@PEI-beta-CD nanocomposite: Modeling by response surface methodology (RSM), boosted regression tree (BRT), and general regression neural network (GRNN).	tet	43-55	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	96-103
31848088-3	2020	Herein, the novel nanocomposite (NC) of Fe3O4-g-CN@PEI-beta-CD was synthesized and employed effectively for the adsorptive removal of tetracycline (TC), the second most produced and employed antibiotic around the world.	tet	134-146	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	55-62
31848088-3	2020	Herein, the novel nanocomposite (NC) of Fe3O4-g-CN@PEI-beta-CD was synthesized and employed effectively for the adsorptive removal of tetracycline (TC), the second most produced and employed antibiotic around the world.	tet	148-150	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	55-62
31848088-5	2020	The Fe3O4-g-CN@PEI-beta-CD NC exhibited fast adsorption rates towards TC and maximum adsorption capacity on the basis of the Langmuir model reached 833.33 mg g-1, much higher than that reported by different carbon- and/or nano-based materials.	tet	70-72	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	19-26
31516076-7	2020	The GPR3 inducible cell line was established using T-REx 293 cells that stably expressed the tetracycline repressor protein, and the cAMP biosensor, GloSensor, was stably co-expressed.	tet	93-105	G protein-coupled receptor 3	Homo sapiens	4-8
32180900-5	2020	Here, we have utilized tetracycline-inducible CRISPR/Cas9 mutagenesis to study the consequences of BCL6 deletion in established DLBCL models in culture and in vivo.	tet	23-35	BCL6 transcription repressor	Homo sapiens	99-103
31882466-7	2020	In RAW264.7 cells stimulated with LPS, Cox2 and Tnfalpha mRNA were over-expressed in the presence of TC.	tet	101-103	prostaglandin-endoperoxide synthase 2	Mus musculus	39-43
31706211-5	2020	Furthermore, As(V) adsorption was due to ion exchange between hydroxyl groups and H2AsO42- groups and H-bonds formed with O-containing groups on Y-GO-SA, and the adsorption of TC by Y-GO-SA was mainly ascribed to electrostatic interaction, H-bonds, pi - pi EDA interaction, n-pi EDA interaction, and cation-bonding bridge effects.	tet	176-178	ectodysplasin A	Homo sapiens	257-260
31706211-5	2020	Furthermore, As(V) adsorption was due to ion exchange between hydroxyl groups and H2AsO42- groups and H-bonds formed with O-containing groups on Y-GO-SA, and the adsorption of TC by Y-GO-SA was mainly ascribed to electrostatic interaction, H-bonds, pi - pi EDA interaction, n-pi EDA interaction, and cation-bonding bridge effects.	tet	176-178	ectodysplasin A	Homo sapiens	279-282
31882466-7	2020	In RAW264.7 cells stimulated with LPS, Cox2 and Tnfalpha mRNA were over-expressed in the presence of TC.	tet	101-103	tumor necrosis factor	Mus musculus	48-56
31882466-9	2020	The anti-inflammatory activity determined on the basis of Cox2 inhibition declined in the order QU>RE>MC>TC.	tet	105-107	prostaglandin-endoperoxide synthase 2	Mus musculus	58-62
31882466-10	2020	Upon application of VLI, only TC down-regulated the expression of LPS-stimulated Cox2 and Tnfalpha mRNA.	tet	30-32	prostaglandin-endoperoxide synthase 2	Mus musculus	81-85
31882466-10	2020	Upon application of VLI, only TC down-regulated the expression of LPS-stimulated Cox2 and Tnfalpha mRNA.	tet	30-32	tumor necrosis factor	Mus musculus	90-98
31882466-11	2020	After exposure to VLI, TC, but not MC, markedly up-regulated hemoxygenase-1 (Ho-1) expression.	tet	23-25	heme oxygenase 1	Mus musculus	61-75
31882466-11	2020	After exposure to VLI, TC, but not MC, markedly up-regulated hemoxygenase-1 (Ho-1) expression.	tet	23-25	heme oxygenase 1	Mus musculus	77-81
31882466-12	2020	CONCLUSION: TC is a chain-breaking antioxidant with a large kinh Upon activation by VLI, TC may undergo degradation and its degradation products affect pleiotropic mediators such as Cox2, Tnfalpha and Ho-1.	tet	12-14	prostaglandin-endoperoxide synthase 2	Mus musculus	182-186
31882466-12	2020	CONCLUSION: TC is a chain-breaking antioxidant with a large kinh Upon activation by VLI, TC may undergo degradation and its degradation products affect pleiotropic mediators such as Cox2, Tnfalpha and Ho-1.	tet	12-14	tumor necrosis factor	Mus musculus	188-196
31882466-12	2020	CONCLUSION: TC is a chain-breaking antioxidant with a large kinh Upon activation by VLI, TC may undergo degradation and its degradation products affect pleiotropic mediators such as Cox2, Tnfalpha and Ho-1.	tet	12-14	heme oxygenase 1	Mus musculus	201-205
31558683-4	2019	METHODS: To examine the molecular mechanisms underlying APOL1 risk variant-induced mitochondrial dysfunction, we generated tetracycline-inducible HEK293 T-REx cells stably expressing the APOL1 nonrisk G0 variant or APOL1 risk variants.	tet	123-135	apolipoprotein L1	Homo sapiens	56-61
31558683-4	2019	METHODS: To examine the molecular mechanisms underlying APOL1 risk variant-induced mitochondrial dysfunction, we generated tetracycline-inducible HEK293 T-REx cells stably expressing the APOL1 nonrisk G0 variant or APOL1 risk variants.	tet	123-135	apolipoprotein L1	Homo sapiens	187-192
31558683-4	2019	METHODS: To examine the molecular mechanisms underlying APOL1 risk variant-induced mitochondrial dysfunction, we generated tetracycline-inducible HEK293 T-REx cells stably expressing the APOL1 nonrisk G0 variant or APOL1 risk variants.	tet	123-135	apolipoprotein L1	Homo sapiens	187-192
31760474-7	2019	Selective and sensitive TET bioanalysis was realized in a linear range of 1 to 250 ng mL-1.	tet	24-27	L1 cell adhesion molecule	Mus musculus	86-90
32198338-0	2019	Mpg-C3N4-ZIF-8 composites for the degradation of tetracycline hydrochloride using visible light.	tet	49-75	N-methylpurine DNA glycosylase	Homo sapiens	0-3
32198338-6	2019	The degradation efficiency of TC was negatively affected under extreme pH conditions, but the composite photocatalyst mpg-C3N4-ZIF-8 had a relatively higher degradation efficiency on TC at mild pH values (4-8).	tet	30-32	N-methylpurine DNA glycosylase	Homo sapiens	118-121
32198338-6	2019	The degradation efficiency of TC was negatively affected under extreme pH conditions, but the composite photocatalyst mpg-C3N4-ZIF-8 had a relatively higher degradation efficiency on TC at mild pH values (4-8).	tet	183-185	N-methylpurine DNA glycosylase	Homo sapiens	118-121
32198338-8	2019	The order of active species affecting the photocatalytic degradation of TC by mpg-C3N4-ZIF-8 was hole > superoxide radical > hydroxyl radical.	tet	72-74	N-methylpurine DNA glycosylase	Homo sapiens	78-81
31697914-5	2019	Transfection of miR-143-3p mimic or overexpression of miR-143-3p using tetracycline-inducible system in MDA-MB-231 cells down-regulated expression of both endogenous PC mRNA and protein by 40% and 50% respectively, confirming the regulatory role of miR-143-3p in PC expression.	tet	71-83	pyruvate carboxylase	Homo sapiens	166-168
31697914-5	2019	Transfection of miR-143-3p mimic or overexpression of miR-143-3p using tetracycline-inducible system in MDA-MB-231 cells down-regulated expression of both endogenous PC mRNA and protein by 40% and 50% respectively, confirming the regulatory role of miR-143-3p in PC expression.	tet	71-83	pyruvate carboxylase	Homo sapiens	263-265
31271653-4	2019	EXPERIMENTAL APPROACH: Human Orai1-3 cDNAs in tetracycline-regulated pcDNA4/TO vectors were transfected into HEK293 T-REx cells with stromal interaction molecule 1 (STIM1) stable expression.	tet	46-58	ORAI calcium release-activated calcium modulator 1	Homo sapiens	29-36
31434054-4	2019	When the concentrations of zinc and tetracycline increased to 3.39 mg L-1 in R1 and 1.0 mg L-1 in R2, an obvious deterioration in performance was observed.	tet	36-48	L1 cell adhesion molecule	Homo sapiens	70-85
31703746-4	2019	Transgenic female Sprague-Dawley rats that inducibly express mutant human TDP-43M337V using the choline acetyltransferase (ChAT) tetracycline response element (TRE) driver with activity modulating tetracycline-controlled transactivator (tTA) were utilized in these studies.	tet	129-141	TAR DNA binding protein	Homo sapiens	74-85
31703746-4	2019	Transgenic female Sprague-Dawley rats that inducibly express mutant human TDP-43M337V using the choline acetyltransferase (ChAT) tetracycline response element (TRE) driver with activity modulating tetracycline-controlled transactivator (tTA) were utilized in these studies.	tet	129-141	choline O-acetyltransferase	Homo sapiens	96-121
31703746-4	2019	Transgenic female Sprague-Dawley rats that inducibly express mutant human TDP-43M337V using the choline acetyltransferase (ChAT) tetracycline response element (TRE) driver with activity modulating tetracycline-controlled transactivator (tTA) were utilized in these studies.	tet	129-141	choline O-acetyltransferase	Homo sapiens	123-127
31703746-4	2019	Transgenic female Sprague-Dawley rats that inducibly express mutant human TDP-43M337V using the choline acetyltransferase (ChAT) tetracycline response element (TRE) driver with activity modulating tetracycline-controlled transactivator (tTA) were utilized in these studies.	tet	197-209	TAR DNA binding protein	Homo sapiens	74-85
31703746-4	2019	Transgenic female Sprague-Dawley rats that inducibly express mutant human TDP-43M337V using the choline acetyltransferase (ChAT) tetracycline response element (TRE) driver with activity modulating tetracycline-controlled transactivator (tTA) were utilized in these studies.	tet	197-209	choline O-acetyltransferase	Homo sapiens	96-121
31703746-4	2019	Transgenic female Sprague-Dawley rats that inducibly express mutant human TDP-43M337V using the choline acetyltransferase (ChAT) tetracycline response element (TRE) driver with activity modulating tetracycline-controlled transactivator (tTA) were utilized in these studies.	tet	197-209	choline O-acetyltransferase	Homo sapiens	123-127
31271653-4	2019	EXPERIMENTAL APPROACH: Human Orai1-3 cDNAs in tetracycline-regulated pcDNA4/TO vectors were transfected into HEK293 T-REx cells with stromal interaction molecule 1 (STIM1) stable expression.	tet	46-58	stromal interaction molecule 1	Homo sapiens	133-163
31301196-5	2019	When Lin28a expression was maintained transiently using the inducible tetracycline-regulated gene expression (Tet-ON) system [doxycycline (Dox)-inducible Lin28a transgenic (iLin28a Tg) mice] with Dox administration at E8.5 and E9.5, it resulted in neonatal lethality, increased body weight (organomegaly), and an increased number of caudal vertebrae at birth.	tet	70-82	lin-28 homolog A	Mus musculus	5-11
32309614-4	2019	To establish a more efficient mouse model for mimicking DBA symptoms, we have taken advantage of RNAi technology to generate an inducible mouse model utilizing tetracycline-induced down-regulation of Rpl5.	tet	160-172	ribosomal protein L5	Mus musculus	200-204
31589296-9	2019	Our in-depth analysis of SCCmec-resistant gene phylogenies reveals that genes such as blaZ, ble, kmA, and tetK that are responsible for beta-lactam, bleomycin, kanamycin, and tetracycline resistance in S. aureus were laterally transferred from non-Staphylococcus sources.	tet	175-187	bleomycin resistance protein Ble	Staphylococcus aureus	92-95
31255282-4	2019	In this study, three compounds isolated from Juniperus oblonga showed anti-proliferative activity against NB cell lines with and without tetracycline inducible MYCN over-expression which were identified as (-)-deoxypodophyllotoxin (1), (-)-matairesinol (2) and (+)-isocupressic acid (3).	tet	137-149	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	160-164
31053878-8	2019	The plasmid-cured ARST lost the ability to express the beta-lactamase gene, which was related to the loss of resistance to ampicillin, cephalothin, kanamycin, penicillin, and tetracycline.	tet	175-187	Bla	Salmonella enterica subsp. enterica serovar Typhimurium	55-69
30844323-8	2019	Conclusions: ESBL-producing K. pneumoniae strains showed high resistance to tetracycline as this antibiotic is used for prophylaxis and therapeutic purposes at the swine farms.	tet	76-88	CTX-M-15	Klebsiella pneumoniae	13-17
31497746-9	2019	Tetracycline-inducible PTPN23 overexpression in human HCC cells resulted in significant inhibition in proliferation, migration, and invasion and in vivo tumorigenesis.	tet	0-12	protein tyrosine phosphatase non-receptor type 23	Homo sapiens	23-29
31430857-0	2019	Tetracycline Analogs Inhibit Osteoclast Differentiation by Suppressing MMP-9-Mediated Histone H3 Cleavage.	tet	0-12	matrix metallopeptidase 9	Danio rerio	71-76
31430857-3	2019	Although it has been reported that several MMP-9 inhibitors, such as tetracycline and its derivatives, show an inhibitory effect on osteoclastogenesis, the molecular mechanisms for this are not fully understood.	tet	69-81	matrix metallopeptidase 9	Danio rerio	43-48
31430857-4	2019	Here we show that tetracycline analogs, especially tigecycline and minocycline, inhibit osteoclast formation by blocking MMP-9-mediated histone H3 tail cleavage.	tet	18-30	matrix metallopeptidase 9	Danio rerio	121-126
31430857-10	2019	Our findings demonstrate that the tetracycline analogs suppress osteoclastogenesis via MMP-9-mediated H3 tail cleavage, and suggest that MMP-9 inhibition could offer a new strategy for the treatment of glucocorticoid-induced osteoporosis.	tet	34-46	matrix metallopeptidase 9	Danio rerio	87-92
31430857-10	2019	Our findings demonstrate that the tetracycline analogs suppress osteoclastogenesis via MMP-9-mediated H3 tail cleavage, and suggest that MMP-9 inhibition could offer a new strategy for the treatment of glucocorticoid-induced osteoporosis.	tet	34-46	matrix metallopeptidase 9	Danio rerio	137-142
30967178-5	2019	The changes of the fluorescence intensity also have a good linear relationship with the concentration of TC in the range of 10.0-400.0 muM, and the detection limit is 6.0 muM.	tet	105-107	latexin	Homo sapiens	135-138
30967178-5	2019	The changes of the fluorescence intensity also have a good linear relationship with the concentration of TC in the range of 10.0-400.0 muM, and the detection limit is 6.0 muM.	tet	105-107	latexin	Homo sapiens	171-174
31370344-12	2019	The highest prevalence of antimicrobial resistance gene was recorded for tetracycline (tet(A):95.25%; tet(B):95.25%) followed by ampicillin (blaTEM:91.25%), streptomycin (aadA1:88.25%), erythromycin (ere(A):84.75%), and trimethoprim (dfrA1:65.5%).	tet	73-85	AadA1	Escherichia coli	171-176
31370344-12	2019	The highest prevalence of antimicrobial resistance gene was recorded for tetracycline (tet(A):95.25%; tet(B):95.25%) followed by ampicillin (blaTEM:91.25%), streptomycin (aadA1:88.25%), erythromycin (ere(A):84.75%), and trimethoprim (dfrA1:65.5%).	tet	73-85	dihydrofolate reductase	Escherichia coli	234-239
31353877-1	2019	Active lipase-producing bacterium Burkholderia gladioli Bps-1 was rapidly isolated using a modified trypan blue and tetracycline, ampicillin (TB-TA) plate.	tet	116-128	ABC transporter ATP-binding protein	Burkholderia gladioli	7-13
31405218-7	2019	The degradation efficiency of tetracycline hydrochloride (TC-HCl, 40mg L-1) can reach 73% in 50 min by employing 0.1% CuS/Bi2WO6 heterostructure as a photo-Fenton-like catalyst.	tet	30-56	L1 cell adhesion molecule	Homo sapiens	71-74
31405218-7	2019	The degradation efficiency of tetracycline hydrochloride (TC-HCl, 40mg L-1) can reach 73% in 50 min by employing 0.1% CuS/Bi2WO6 heterostructure as a photo-Fenton-like catalyst.	tet	58-64	L1 cell adhesion molecule	Homo sapiens	71-74
31484266-8	2019	Set1 gene that did not appear in all the 16 strains were highly resistant to ampicillin, tetracycline, compound xinnomine, cefazoline, cefotaxime, gentamicin, naphthidinic acid and streptomycin, including 9 strains to doxycycline.	tet	89-101	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	0-4
31082708-7	2019	The experiment demonstrated two mechanisms of chlorophyll degradation to pheophytin by tetracycline hydrochloride, i.e. 1) loss of Mg2+ ions from the chlorophyll molecule as a result of the presence of H+ ions in solution (i.e. as a result of medium acidification), and 2) removal of Mg2+ ions directly from chlorophyll by tetracycline which binds Mg2+ ions from the chlorophyll.	tet	87-113	mucin 7, secreted	Homo sapiens	131-134
31082708-7	2019	The experiment demonstrated two mechanisms of chlorophyll degradation to pheophytin by tetracycline hydrochloride, i.e. 1) loss of Mg2+ ions from the chlorophyll molecule as a result of the presence of H+ ions in solution (i.e. as a result of medium acidification), and 2) removal of Mg2+ ions directly from chlorophyll by tetracycline which binds Mg2+ ions from the chlorophyll.	tet	87-99	mucin 7, secreted	Homo sapiens	131-134
31082708-7	2019	The experiment demonstrated two mechanisms of chlorophyll degradation to pheophytin by tetracycline hydrochloride, i.e. 1) loss of Mg2+ ions from the chlorophyll molecule as a result of the presence of H+ ions in solution (i.e. as a result of medium acidification), and 2) removal of Mg2+ ions directly from chlorophyll by tetracycline which binds Mg2+ ions from the chlorophyll.	tet	87-99	mucin 7, secreted	Homo sapiens	284-287
31082708-7	2019	The experiment demonstrated two mechanisms of chlorophyll degradation to pheophytin by tetracycline hydrochloride, i.e. 1) loss of Mg2+ ions from the chlorophyll molecule as a result of the presence of H+ ions in solution (i.e. as a result of medium acidification), and 2) removal of Mg2+ ions directly from chlorophyll by tetracycline which binds Mg2+ ions from the chlorophyll.	tet	87-99	mucin 7, secreted	Homo sapiens	284-287
31082708-8	2019	We demonstrated that magnesium occurring in low concentrations attached to a tetracycline molecule in the BCD ring, and that the second ion of Mg2+ may attach to the A ring of tetracycline at higher Mg2+ concentrations.	tet	176-188	mucin 7, secreted	Homo sapiens	143-146
31082708-8	2019	We demonstrated that magnesium occurring in low concentrations attached to a tetracycline molecule in the BCD ring, and that the second ion of Mg2+ may attach to the A ring of tetracycline at higher Mg2+ concentrations.	tet	176-188	mucin 7, secreted	Homo sapiens	199-202
31157350-8	2019	The presence of inorganic anions enhanced the mobility of tetracycline following the order of H2PO4- &gt; SO42- &gt; NO3- &gt; Cl-.	tet	58-70	NBL1, DAN family BMP antagonist	Homo sapiens	117-120
31497746-9	2019	Tetracycline-inducible PTPN23 overexpression in human HCC cells resulted in significant inhibition in proliferation, migration, and invasion and in vivo tumorigenesis.	tet	0-12	HCC	Homo sapiens	54-57
31266502-3	2019	Recently, we demonstrated that minocycline, a tetracycline antibiotic, successfully inhibited the TNF-alpha-induced fusion of MDA-MB-435 cancer cells with M13SV1 breast epithelial cells.	tet	46-58	tumor necrosis factor	Homo sapiens	98-107
31171783-2	2019	Unexpectedly, we found that in a different mouse line with a targeted-insertion of the same transgene driven by the same tetracycline-TransActivator (tTA) allele, but with even higher overexpression of tauP301L than rTg4510, atrophy and tau histopathology are delayed, and a different behavioral profile is observed.	tet	121-133	microtubule associated protein tau	Homo sapiens	202-205
30395227-2	2019	To study HIF-1 signalling in the heart, we developed a mouse model in which an oxygen-stable form of HIF-1alpha can be inducibly expressed in cardiac myocytes, under the regulation of tetracycline.	tet	184-196	hypoxia inducible factor 1, alpha subunit	Mus musculus	101-111
31000165-2	2019	The enzymatic activity and functional genes abundance associated with nitrification and denitrification at a 20 mg L-1 TC stress were higher than those at a mixtures stress of 20 mg L-1 TC and 10 mg L-1 Cu(II), while they were lower than those at a mixtures stress of 20 mg L-1 TC and 40 mg L-1 Cu(II).	tet	119-121	L1 cell adhesion molecule	Homo sapiens	115-118
31000165-2	2019	The enzymatic activity and functional genes abundance associated with nitrification and denitrification at a 20 mg L-1 TC stress were higher than those at a mixtures stress of 20 mg L-1 TC and 10 mg L-1 Cu(II), while they were lower than those at a mixtures stress of 20 mg L-1 TC and 40 mg L-1 Cu(II).	tet	186-188	L1 cell adhesion molecule	Homo sapiens	182-185
31000165-2	2019	The enzymatic activity and functional genes abundance associated with nitrification and denitrification at a 20 mg L-1 TC stress were higher than those at a mixtures stress of 20 mg L-1 TC and 10 mg L-1 Cu(II), while they were lower than those at a mixtures stress of 20 mg L-1 TC and 40 mg L-1 Cu(II).	tet	186-188	L1 cell adhesion molecule	Homo sapiens	182-185
31000165-2	2019	The enzymatic activity and functional genes abundance associated with nitrification and denitrification at a 20 mg L-1 TC stress were higher than those at a mixtures stress of 20 mg L-1 TC and 10 mg L-1 Cu(II), while they were lower than those at a mixtures stress of 20 mg L-1 TC and 40 mg L-1 Cu(II).	tet	186-188	L1 cell adhesion molecule	Homo sapiens	182-185
30995417-2	2019	In this study, we utilized the tetracycline-regulatable Tet-On 3G system to control the expression of c-Jun, which is a common regulator of multiple NTFs in Schwann cells (SCs).	tet	31-43	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-107
31250621-3	2019	In this study, we established a tetracycline (Tet)-inducible nuclear aggregate (beta23) expression model to screen potential lead compounds inhibiting beta23-induced toxicity.	tet	32-44	immunoglobulin kappa variable 2-24	Homo sapiens	80-86
31250621-3	2019	In this study, we established a tetracycline (Tet)-inducible nuclear aggregate (beta23) expression model to screen potential lead compounds inhibiting beta23-induced toxicity.	tet	32-44	immunoglobulin kappa variable 2-24	Homo sapiens	151-157
31250621-3	2019	In this study, we established a tetracycline (Tet)-inducible nuclear aggregate (beta23) expression model to screen potential lead compounds inhibiting beta23-induced toxicity.	tet	46-49	immunoglobulin kappa variable 2-24	Homo sapiens	80-86
31250621-3	2019	In this study, we established a tetracycline (Tet)-inducible nuclear aggregate (beta23) expression model to screen potential lead compounds inhibiting beta23-induced toxicity.	tet	46-49	immunoglobulin kappa variable 2-24	Homo sapiens	151-157
31250621-9	2019	Taken together, our results suggest that a Tet-Off beta23 cell model could serve as a robust platform for screening effective lead compounds inhibiting nuclear or cytosolic protein aggregates.	tet	43-46	immunoglobulin kappa variable 2-24	Homo sapiens	51-57
31056648-2	2019	Based on our previous data showing that doxycycline and minocycline work as the positive allosteric modulator (PAM) of PAC1-R, we used computer molecular docking and isothermal titration calorimetry assay to further determine the bindings of doxycycline/minocycline"s derivatives including tetracycline/tigecycline with the N-terminal extracellular domain of PAC1-R (PAC1-EC1).	tet	290-302	ADCYAP receptor type I	Homo sapiens	119-125
31056648-2	2019	Based on our previous data showing that doxycycline and minocycline work as the positive allosteric modulator (PAM) of PAC1-R, we used computer molecular docking and isothermal titration calorimetry assay to further determine the bindings of doxycycline/minocycline"s derivatives including tetracycline/tigecycline with the N-terminal extracellular domain of PAC1-R (PAC1-EC1).	tet	290-302	ADCYAP receptor type I	Homo sapiens	119-123
31056648-4	2019	The results showed that tetracycline/tigecycline had significant lower affinity to PAC1-EC1 than doxycycline/minocycline, which was consistent with their non-positive allosteric modulation activity on PAC1-R.	tet	24-36	ADCYAP receptor type I	Homo sapiens	83-87
31056648-4	2019	The results showed that tetracycline/tigecycline had significant lower affinity to PAC1-EC1 than doxycycline/minocycline, which was consistent with their non-positive allosteric modulation activity on PAC1-R.	tet	24-36	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	88-91
31056648-4	2019	The results showed that tetracycline/tigecycline had significant lower affinity to PAC1-EC1 than doxycycline/minocycline, which was consistent with their non-positive allosteric modulation activity on PAC1-R.	tet	24-36	ADCYAP receptor type I	Homo sapiens	201-207
31208373-8	2019	A lung tumor model with ectopic Nanos3 expression was based on the lung-specific activation of the reverse tetracycline transactivator gene, in combination with a tetO-CMV promoter controlling Cre expression.	tet	107-119	nanos C2HC-type zinc finger 3	Homo sapiens	32-38
30940592-4	2019	At screening test, NST/CS had the highest tetracycline degradation efficiency of 91% for duration of 20 min under visible light.	tet	42-54	citrate synthase	Homo sapiens	23-25
31285943-11	2019	Furthermore, the cells grown with tetracycline-treated titanium disks showed significantly lower VEGF production than those in the SA group.	tet	34-46	vascular endothelial growth factor A	Homo sapiens	97-101
30942445-4	2019	In the present study, using a tetracycline-inducible system in PTEN-null U87 cells, we demonstrate that MARCKS overexpression suppresses growth and enhances radiation sensitivity in vivo.	tet	30-42	phosphatase and tensin homolog	Homo sapiens	63-67
30942445-4	2019	In the present study, using a tetracycline-inducible system in PTEN-null U87 cells, we demonstrate that MARCKS overexpression suppresses growth and enhances radiation sensitivity in vivo.	tet	30-42	myristoylated alanine rich protein kinase C substrate	Homo sapiens	104-110
31005730-7	2019	Including the blaNDM-1 gene, in total 13 resistance genes were identified in E. cloacae EC32 conferring resistance to beta-lactams, rifampicin, phenicols, fosfomycin, macrolides, quinolones, sulfonamides and tetracycline.	tet	208-220	metallo-beta-lactamase NDM-1	Enterobacter cloacae	14-22
30731253-0	2019	Interaction of tetracycline with l-cysteine functionalized CdS quantum dots - Fundamentals and sensing application.	tet	15-27	CDP-diacylglycerol synthase 1	Homo sapiens	59-62
30900284-2	2019	METHODS: To study the role of IL-1beta expression in prostate inflammation, we examined IL1B expression in human prostatic proliferative inflammatory atrophy (PIA) lesions and developed a tetracycline-regulated human IL1B transgene in the mouse prostate.	tet	188-200	interleukin 1 beta	Homo sapiens	217-221
30739031-2	2019	The visible-light-induced LDH/CN/RGO ternary heterojunctions displayed significantly enhanced photocatalytic performance towards the degradation of aqueous Congo red (CR, dye) and tetracycline (TC, antibiotic) contaminants, which is far superior to that observed for pristine CN (base material), LDH, P25 (reference), and binary CN/RGO and LDH/CN heterojunctions.	tet	180-192	tubulin polymerization promoting protein	Homo sapiens	301-304
30739031-2	2019	The visible-light-induced LDH/CN/RGO ternary heterojunctions displayed significantly enhanced photocatalytic performance towards the degradation of aqueous Congo red (CR, dye) and tetracycline (TC, antibiotic) contaminants, which is far superior to that observed for pristine CN (base material), LDH, P25 (reference), and binary CN/RGO and LDH/CN heterojunctions.	tet	194-196	tubulin polymerization promoting protein	Homo sapiens	301-304
31142623-2	2019	This was recently achieved for a single gene by exploiting negative autoregulation by the tetracycline repressor (TetR) and bicistronic gene expression to reduce gene expression noise.	tet	90-102	tetracycline resistance repressor protein TetR	Escherichia coli	114-118
31120904-6	2019	Next, we modelled gradual decrease of ACADS expression using a tetracycline-regulated shRNA-knockdown of ACADS in Huh7 hepatocytes, a cell line with high fatty acid oxidation-(FAO)-capacity.	tet	63-75	acyl-CoA dehydrogenase short chain	Homo sapiens	38-43
31120904-6	2019	Next, we modelled gradual decrease of ACADS expression using a tetracycline-regulated shRNA-knockdown of ACADS in Huh7 hepatocytes, a cell line with high fatty acid oxidation-(FAO)-capacity.	tet	63-75	acyl-CoA dehydrogenase short chain	Homo sapiens	105-110
31120904-6	2019	Next, we modelled gradual decrease of ACADS expression using a tetracycline-regulated shRNA-knockdown of ACADS in Huh7 hepatocytes, a cell line with high fatty acid oxidation-(FAO)-capacity.	tet	63-75	MIR7-3 host gene	Homo sapiens	114-118
31100078-4	2019	The in vitro biochemical properties of these two rhodopsin proteins, expressed in stably transfected tetracycline-inducible HEK293S cells, their UV-visible absorption, their Fourier transform infrared, circular dichroism and Metarhodopsin II fluorescence spectroscopy properties were characterized.	tet	101-113	rhodopsin	Homo sapiens	49-58
31044197-4	2019	The obtained tetracycline (Tet)@ZIF-8@ hyaluronic acid (HA) system (abbreviated to TZH) can be taken up by cells owing to the presence of CD44 receptors on the cell surface via an HA-mediated pathway.	tet	13-25	CD44 molecule (Indian blood group)	Homo sapiens	138-142
31044197-4	2019	The obtained tetracycline (Tet)@ZIF-8@ hyaluronic acid (HA) system (abbreviated to TZH) can be taken up by cells owing to the presence of CD44 receptors on the cell surface via an HA-mediated pathway.	tet	27-30	CD44 molecule (Indian blood group)	Homo sapiens	138-142
30900284-2	2019	METHODS: To study the role of IL-1beta expression in prostate inflammation, we examined IL1B expression in human prostatic proliferative inflammatory atrophy (PIA) lesions and developed a tetracycline-regulated human IL1B transgene in the mouse prostate.	tet	188-200	interleukin 1 beta	Homo sapiens	30-38
30716695-9	2019	TC removal efficiency of IS-NiFe in column reactors was tested with TC (20 mg/L) spiked lake water, ground water, and tap water and the removal capacity was noted to be 698.55 +- 11.21, 764.17 +- 6.78, and 801.7 +- 13.26 mg/g respectively.	tet	0-2	nuclear RNA export factor 1	Homo sapiens	118-121
30731253-1	2019	The present paper reports l-cysteine functionalized CdS quantum dots (QDs) as a simple and highly selective turn-off fluorescence sensor for the determination of tetracycline (TET).	tet	162-174	CDP-diacylglycerol synthase 1	Homo sapiens	52-55
30731253-1	2019	The present paper reports l-cysteine functionalized CdS quantum dots (QDs) as a simple and highly selective turn-off fluorescence sensor for the determination of tetracycline (TET).	tet	176-179	CDP-diacylglycerol synthase 1	Homo sapiens	52-55
31024566-3	2019	An experimental in vivo immunosuppressive mouse model of IL-7 hyperexpression was developed using transgenic mice (C57BL/6 background) carrying a tetracycline inducible IL-7 expression cassette, which allowed the temporally controlled induction of IL-7 hyperexpression by Dexamethasone and Doxycycline treatment.	tet	146-158	interleukin 7	Mus musculus	57-61
31024566-3	2019	An experimental in vivo immunosuppressive mouse model of IL-7 hyperexpression was developed using transgenic mice (C57BL/6 background) carrying a tetracycline inducible IL-7 expression cassette, which allowed the temporally controlled induction of IL-7 hyperexpression by Dexamethasone and Doxycycline treatment.	tet	146-158	interleukin 7	Mus musculus	169-173
31024566-3	2019	An experimental in vivo immunosuppressive mouse model of IL-7 hyperexpression was developed using transgenic mice (C57BL/6 background) carrying a tetracycline inducible IL-7 expression cassette, which allowed the temporally controlled induction of IL-7 hyperexpression by Dexamethasone and Doxycycline treatment.	tet	146-158	interleukin 7	Mus musculus	169-173
30878136-5	2019	To test this hypothesis, transgenic mice with doxycycline-inducible expression of murine vascular endothelial growth factor (VEGF)-D under a tightly controlled Tet-On promoter were crossed with adipocyte-specific adiponectin-reverse tetracycline-dependent transactivator mice (Adipo-VD) to stimulate adipose tissue-specific lymphangiogenesis during 16-week high-fat diet-induced obesity.	tet	233-245	vascular endothelial growth factor D	Mus musculus	89-132
30987227-11	2019	When MA5 was screened for antibiotic resistance, broad resistance against penicillin, streptomycin, tetracycline, ampicillin, rifampicin, and erythromycin was found; this correlated with the presence of multiple gene determinants for antibiotic resistance within the whole genome sequence of MA5.	tet	100-112	PNMA family member 3	Homo sapiens	5-8
30987262-5	2019	To investigate whether restored expression of HO-1 in APCs could alter the development of diabetes in NOD mice, we generated a transgenic mouse strain in which HO-1 expression can be specifically induced in DCs using a tetracycline-controlled transcriptional activation system.	tet	219-231	heme oxygenase 1	Mus musculus	160-164
30656518-5	2019	METHODS: We developed a lentiviral vector system that contains reverse tetracycline-controlled transactivator 3 (rtTA3) and the TRE promoter, which are necessary for the doxycycline-inducible expression of shRNAs that are expressed as intronic miR-30a precursors.	tet	71-83	microRNA 30a	Homo sapiens	244-251
30802555-8	2019	Phenotypic resistance to tetracycline was found in more than 50% of the porcine, bovine, and canine isolates, which carried a wide range of plasmids of 2-100 kb size, most of which had the tcpH clostridial transfer gene.	tet	25-37	tcpH	Clostridium perfringens	189-193
30802555-10	2019	Some strains that carried &lt;40 kb plasmids and had the tcpH gene also had one or more toxin genes or tetracycline-resistance gene.	tet	103-115	tcpH	Clostridium perfringens	57-61
30639664-3	2019	Especially, the refractory tetracycline (20 mg L-1) can be completely removed within 6.0 min with a dosage of 30 mg of AgBiO3/GO/NCDs under the assistance of peroxymonosulfate (PMS, 0.2 mM).	tet	27-39	immunoglobulin kappa variable 1-16	Homo sapiens	47-50
30708251-4	2019	Besides, the photocatalytic efficiencies of MCU-C3N4/PVDF for rhodamine B (RhB) and tetracycline hydrochloride (TC) degradation are 84.24% and 71.26% respectively, which are about 8 times higher than that of the original membrane.	tet	84-110	mitochondrial calcium uniporter	Homo sapiens	44-47
30708251-4	2019	Besides, the photocatalytic efficiencies of MCU-C3N4/PVDF for rhodamine B (RhB) and tetracycline hydrochloride (TC) degradation are 84.24% and 71.26% respectively, which are about 8 times higher than that of the original membrane.	tet	112-114	mitochondrial calcium uniporter	Homo sapiens	44-47
30102766-0	2019	Tetracycline Removal Under Solar Illumination Over Ag3 VO4 /mpg-C3 N4 Heterojunction Photocatalysts.	tet	0-12	N-methylpurine DNA glycosylase	Homo sapiens	60-63
30496862-5	2019	The pseudo-second-order kinetic and Freundlich isotherm models combining with the correlative analysis implied that the tetracycline adsorption onto the Cu-immobilized alginate adsorbent was administrated by the n-pi electron-donor-acceptor interaction (n-pi EDA interaction), hydrogen bond and the cation bonding bridge.	tet	120-132	ectodysplasin A	Homo sapiens	259-262
30884789-5	2019	Using the quantitative E test, the minimal inhibitory concentration (MIC) of tetracycline was determined to be 1.0 microg mL-1.	tet	77-89	L1 cell adhesion molecule	Mus musculus	122-126
30884789-7	2019	Results indicated that 1.0 microg mL-1 tetracycline was effective in restricting bacterial growth, with non-significant negative effects on explants at low concentrations, but were enhanced negative effects at high concentrations.	tet	39-51	L1 cell adhesion molecule	Mus musculus	34-38
30573097-6	2019	Tetracycline resistance genes (tet(A), tet(B), tet(D), tet(E) and tet(O), beta-lactam resistance genes (SHV, TEM, CTX, OXA and OXY) and sulfonamide resistance genes (sulA, sul1, sul2, sul3 and int-1) were detected.	tet	0-12	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	114-117
30102766-2	2019	The prepared Ag3 VO4 /mpg-C3 N4 heterojunctions were used to remove tetracycline (TC), a kind of antibiotics widely released into the aquatic environment under solar irradiation.	tet	68-80	N-methylpurine DNA glycosylase	Homo sapiens	22-25
30102766-2	2019	The prepared Ag3 VO4 /mpg-C3 N4 heterojunctions were used to remove tetracycline (TC), a kind of antibiotics widely released into the aquatic environment under solar irradiation.	tet	82-84	N-methylpurine DNA glycosylase	Homo sapiens	22-25
30102766-6	2019	In addition, a possible mechanism and intermediate products for the Ag3 VO4 /mpg-C3 N4 photocatalysts toward the photodegradation of TC in aqueous solution under artificial sunlight radiation were proposed based on the scavengers trapping test, ESR spectra and a high-performance liquid chromatography (HPLC) coupled with mass spectrometer (MS) analysis.	tet	133-135	N-methylpurine DNA glycosylase	Homo sapiens	77-80
30485744-8	2019	When tested on other PTPs, PTP1B and SHP1, it was found that the tetracycline PTP1B, SHP1, the tetracycline variant (doxycycline), and the sulfonated azo dye (Congo red) are selective inhibitors of Sts-1HP, with selectivity indices ranging from 19 to as high as 200.	tet	65-77	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	27-32
30312908-4	2019	The results showed that the adsorption capacities of a gel disc containing 2.5 g L-1 of nanoZnO particles were as high as 3.93 +- 0.20 mg disc-1 for TC, 3.21 +- 0.20 mg disc-1 for OTC and 4.62 +- 0.22 mg disc-1 for CTC.	tet	149-151	DISC1 scaffold protein	Sus scrofa	138-144
30485744-8	2019	When tested on other PTPs, PTP1B and SHP1, it was found that the tetracycline PTP1B, SHP1, the tetracycline variant (doxycycline), and the sulfonated azo dye (Congo red) are selective inhibitors of Sts-1HP, with selectivity indices ranging from 19 to as high as 200.	tet	95-107	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	37-41
30485744-8	2019	When tested on other PTPs, PTP1B and SHP1, it was found that the tetracycline PTP1B, SHP1, the tetracycline variant (doxycycline), and the sulfonated azo dye (Congo red) are selective inhibitors of Sts-1HP, with selectivity indices ranging from 19 to as high as 200.	tet	65-77	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	37-41
30485744-8	2019	When tested on other PTPs, PTP1B and SHP1, it was found that the tetracycline PTP1B, SHP1, the tetracycline variant (doxycycline), and the sulfonated azo dye (Congo red) are selective inhibitors of Sts-1HP, with selectivity indices ranging from 19 to as high as 200.	tet	65-77	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	78-83
30414172-5	2019	Several proteins have been involved in the connective tissue abnormalities associated with the FXS, such as matrix metalloproteinase 9, which plays an important role in the homeostasis of the ECM, being a potential therapeutic target for certain tetracycline antibiotics that have shown beneficial effects in FXS.	tet	246-258	matrix metallopeptidase 9	Homo sapiens	108-134
30565421-3	2019	Furthermore, the floating system exhibits an excellent photodegradation of tetracycline (TC; 40 mg L-1 ).	tet	75-87	L1 cell adhesion molecule	Homo sapiens	99-102
30603914-0	2019	The proliferative lifespan of adult sheep fibroblasts can be conditionally extended by tetracycline-inducible expression of human telomerase reverse transcriptase.	tet	87-99	telomerase reverse transcriptase	Homo sapiens	130-162
30603914-2	2019	Here, we report conditional extension of proliferative lifespan of adult sheep somatic cells by introducing tetracycline-inducible (Tet-on) expression of hTERT.	tet	108-120	telomerase reverse transcriptase	Homo sapiens	154-159
30603914-3	2019	After transfecting adult sheep fibroblasts with the vector for Tet-on induced conditional expression of hTERT, we obtained several hTERT-positive clones that exhibited extended-lifespan under the induction of tetracycline analogue, doxycycline.	tet	209-221	telomerase reverse transcriptase	Homo sapiens	131-136
30716538-4	2019	In this study, HEK293 cells with tetracycline-inducible Nox4 overexpression (HEK-tet-Nox4), as well as podocytes of WT and Nox4-/- mice, were utilized to identify Nox4-dependent redox-modified proteins.	tet	33-45	NADPH oxidase 4	Homo sapiens	56-60
30745870-3	2019	In this work, we developed a tetracycline-inducible expression system, with simultaneous induced expression of alpha-syn-EGFP and a bright red fluorescent protein marker (mCherry) to screen for potential compounds for degrading alpha-syn.	tet	29-41	synuclein alpha	Homo sapiens	111-120
30745870-3	2019	In this work, we developed a tetracycline-inducible expression system, with simultaneous induced expression of alpha-syn-EGFP and a bright red fluorescent protein marker (mCherry) to screen for potential compounds for degrading alpha-syn.	tet	29-41	synuclein alpha	Homo sapiens	228-237
30565421-3	2019	Furthermore, the floating system exhibits an excellent photodegradation of tetracycline (TC; 40 mg L-1 ).	tet	89-91	L1 cell adhesion molecule	Homo sapiens	99-102
30538170-0	2019	Procaspase activating compound 1 controls tetracycline repressor-regulated gene expression system.	tet	42-54	ADCYAP receptor type I	Homo sapiens	0-32
30308294-4	2019	As a result, tetracycline and erythromycin promoted the growth and digestive activity of lipase, pepsin, and trypsin, but norfloxacin did not show significant prompting effect on digestive activity and even retarded the weight gain of the sea cucumbers.	tet	13-25	lipase	Cucumis sativus	89-95
30663696-7	2019	Moreover, the presence of a tetracycline inducer (rtTA) element in the transgenic construct enables an inducible and reversible regulation of the RB1 protein.	tet	28-40	RB transcriptional corepressor 1	Mus musculus	146-149
30316158-2	2019	The TC adsorption isotherm on SCG-1 was compared with SCG-2.	tet	4-6	chromogranin B	Homo sapiens	30-35
30316158-3	2019	The results showed that the removal efficiencies of TC (50 mg/L) of SCG-1 and SCG-2 were 83.1% and 97.2%, respectively, shake for 2 h. The probability of adsorption is high and balances in about 20 min.	tet	52-54	chromogranin B	Homo sapiens	68-73
30316158-3	2019	The results showed that the removal efficiencies of TC (50 mg/L) of SCG-1 and SCG-2 were 83.1% and 97.2%, respectively, shake for 2 h. The probability of adsorption is high and balances in about 20 min.	tet	52-54	secretogranin II	Homo sapiens	78-83
30316158-4	2019	The estimate of parameters got for TC from the Langmuir isotherm saturated adsorption quantity and adsorption balance constant were 64.89 mg/g, 0.0557 L/mg, respectively for SCG-1 and 123.46 mg/g, 0.4735 L/mg, respectively for SCG-2.	tet	35-37	chromogranin B	Homo sapiens	174-179
30316158-4	2019	The estimate of parameters got for TC from the Langmuir isotherm saturated adsorption quantity and adsorption balance constant were 64.89 mg/g, 0.0557 L/mg, respectively for SCG-1 and 123.46 mg/g, 0.4735 L/mg, respectively for SCG-2.	tet	35-37	secretogranin II	Homo sapiens	227-232
30389335-14	2019	GBS isolates of CPS V/ST1 and CPS III/ST23 were significantly associated with macrolide and tetracycline resistance, respectively.	tet	92-104	syndecan binding protein	Homo sapiens	22-25
30514244-5	2018	METHODS: For that purpose, we constructed tetracycline-inducible EMX2 expression lines.	tet	42-54	empty spiracles homeobox 2	Homo sapiens	65-69
30342060-7	2019	Next, we used a tetracycline-inducible miR-132 overexpression mouse model and a miR-132/212 conditional knockout (cKO) mouse model to examine whether dysregulation of miR-132/212 expression alters basal anxiety-like behaviors.	tet	16-28	microRNA 132	Mus musculus	39-46
30212672-7	2018	PEP/ZVI process was tested for several emerging pollutants (benzotriazole, 4-chlorophenol, carmoisine and tetracycline); the results presented the effectiveness of the process for the degradation of pollutants in a way that complete degradation occurred at only 30 min.	tet	106-118	prolyl endopeptidase	Homo sapiens	0-3
30337459-0	2019	Influence of Mg2+ on the conformational flexibility of a tetracycline aptamer.	tet	57-69	mucin 7, secreted	Homo sapiens	13-16
30337459-4	2019	TC was found to be the essential factor for stabilizing the tertiary structure at intermediate Mg2+ concentrations.	tet	0-2	mucin 7, secreted	Homo sapiens	95-98
31190707-3	2019	This study aimed to investigate the presence of tetracycline and penicillin residues in raw, pasteurized, and UHT cow"s milk of different fat contents, as well as in the dairy products yogurt and labneh, a traditional Lebanese product.	tet	48-60	UHT	Bos taurus	110-113
30701028-4	2018	Tetracycline-regulatable LOX re-expression in Odc cells led to inhibition of cell growth and invasion in three-dimensional Matrigel in an activity-independent manner.	tet	0-12	lysyl oxidase	Homo sapiens	25-28
30701028-4	2018	Tetracycline-regulatable LOX re-expression in Odc cells led to inhibition of cell growth and invasion in three-dimensional Matrigel in an activity-independent manner.	tet	0-12	ornithine decarboxylase 1	Homo sapiens	46-49
30510124-4	2018	In this protocol, we describe how to identify a silent but highly activatable genomic site by taking advantage of transgenic lines reliably expressing the tetracycline transactivators from the Rosa-26 locus.	tet	155-167	gene trap ROSA 26, Philippe Soriano	Mus musculus	193-200
30244920-8	2018	In a different set of experiments, we used a tetracycline-inducible (tet-off) lentiviral vector to overexpress D3R to assess its gain-of-function in the hippocampus on anxiety- and depression-like behaviors.	tet	45-57	dopamine receptor D3	Mus musculus	111-114
30053688-4	2018	The photocatalytic performance of the MCU(DMSO)-C3N4 was evaluated under visible light irradiation using rhodamine B (RhB), tetracycline hydrochloride (TC), and ciprofloxacin (CIP) as target pollutants.	tet	124-150	mitochondrial calcium uniporter	Homo sapiens	38-41
30053688-4	2018	The photocatalytic performance of the MCU(DMSO)-C3N4 was evaluated under visible light irradiation using rhodamine B (RhB), tetracycline hydrochloride (TC), and ciprofloxacin (CIP) as target pollutants.	tet	152-154	mitochondrial calcium uniporter	Homo sapiens	38-41
30125775-0	2018	Removal of tetracycline from aqueous solution by MOF/graphite oxide pellets: Preparation, characteristic, adsorption performance and mechanism.	tet	11-23	lysine acetyltransferase 8	Homo sapiens	49-52
30365084-2	2018	In the present study, experiments were conducted to evaluate the contribution of a tetracycline inducible lentiviral-mediated delivery system for the expression of TLR4 small interfering (si)RNA to NP in rats with chronic constriction injury (CCI).	tet	83-95	toll-like receptor 4	Rattus norvegicus	164-168
30105595-6	2018	We developed a mouse model in which GLUT9 was deleted specifically along the whole nephron in a tetracycline-inducible manner (subsequently called kidney-inducible KO or kiKO).	tet	96-108	solute carrier family 2 (facilitated glucose transporter), member 9	Mus musculus	36-41
30532496-12	2018	Antibiogram of these ESBL-positive isolates revealed the drugs such as colistin (100%), levofloxacin (83.33%), and imipenem (66.67%) to be highly sensitive against this pathogen but drugs such as cefotaxime (100%), ceftazidime (91.67%), amoxicillin/clavulanic acid (83.33%), tetracycline (75.00%), and gentamicin (58.33%) to be very much resistant.	tet	275-287	EsbL	Escherichia coli	21-25
30031366-12	2018	Under the synergistic influence of water constituents (including acidity and alkalinity, ion species and dissolved organic substances), various water matrices greatly affected the degradation rate of TC-HCl, with the highest removal efficiency of 78.9% in natural seawater, followed by reservoir water (75.0%), tap water (62.3%), deionized water (49.8%), reverse osmosis concentrate (32.7%) and pharmaceutical wastewater (18.9%).	tet	200-206	nuclear RNA export factor 1	Homo sapiens	311-314
30187708-5	2018	Also, stable Cdc25B2 and Cdc25B3 overexpression HeLa cell lines were constructed using the tetracycline-regulated expression system and were applied as a tool for screening for inhibitors of Cdc25B.	tet	91-103	cell division cycle 25B	Homo sapiens	13-19
30304687-5	2018	By integrating the cryptochrome 2-cryptochrome-interacting basic helix-loop-helix 1 (Cry2-CIB1) light-inducible binding switch, expression of the gene of interest is tightly regulated under the control of light illumination and drug application in our PA-Tet-OFF/ON system.	tet	255-258	cryptochrome circadian regulator 2	Homo sapiens	85-89
30304687-5	2018	By integrating the cryptochrome 2-cryptochrome-interacting basic helix-loop-helix 1 (Cry2-CIB1) light-inducible binding switch, expression of the gene of interest is tightly regulated under the control of light illumination and drug application in our PA-Tet-OFF/ON system.	tet	255-258	calcium and integrin binding 1	Homo sapiens	90-94
30214566-7	2018	Reverse transcription-quantitative polymerase chain reaction revealed that the expression of PVT1 and ANRIL was significantly inhibited by the tetracycline-inducible CRISPR/Cas9 system.	tet	143-155	Pvt1 oncogene	Homo sapiens	93-97
30214566-7	2018	Reverse transcription-quantitative polymerase chain reaction revealed that the expression of PVT1 and ANRIL was significantly inhibited by the tetracycline-inducible CRISPR/Cas9 system.	tet	143-155	CDKN2B antisense RNA 1	Homo sapiens	102-107
30187708-5	2018	Also, stable Cdc25B2 and Cdc25B3 overexpression HeLa cell lines were constructed using the tetracycline-regulated expression system and were applied as a tool for screening for inhibitors of Cdc25B.	tet	91-103	cell division cycle 25B	Homo sapiens	25-31
30323899-3	2018	We manipulated BRCA1 expression using tetracycline in the UBR60-bcl2 cell line (which has an inducible, tetracycline-regulated BRCA1 expression) and siRNA in oestrogen receptor(ER)-positive MCF7 and T47D breast cancer cells.	tet	38-50	BRCA1 DNA repair associated	Homo sapiens	15-20
30323899-3	2018	We manipulated BRCA1 expression using tetracycline in the UBR60-bcl2 cell line (which has an inducible, tetracycline-regulated BRCA1 expression) and siRNA in oestrogen receptor(ER)-positive MCF7 and T47D breast cancer cells.	tet	104-116	BRCA1 DNA repair associated	Homo sapiens	127-132
29641324-0	2018	Gene Therapy with Tetracycline-Regulated Human Recombinant COLIA1 cDNA Direct Adenoviral Delivery Enhances Fracture Healing in Osteoporotic Rats.	tet	18-30	collagen type I alpha 1 chain	Rattus norvegicus	59-65
29807336-0	2018	A label-free aptasensor for the detection of tetracycline based on the luminescence of SYBR Green I.	tet	45-57	semenogelin 1	Homo sapiens	87-99
29807336-1	2018	A novel fluorescent method based on tetracycline-binding aptamers and the luminescence of SYBR Green I (SGI) was established for the sensitive and selective detection of tetracycline.	tet	170-182	semenogelin 1	Homo sapiens	90-102
29807336-1	2018	A novel fluorescent method based on tetracycline-binding aptamers and the luminescence of SYBR Green I (SGI) was established for the sensitive and selective detection of tetracycline.	tet	170-182	semenogelin 1	Homo sapiens	104-107
29807336-9	2018	Therefore, the biosensor based on the specific recognition of aptamers and the fluorescence properties of SGI can detect the tetracycline in milk accurately, rapidly and specifically.	tet	125-137	semenogelin 1	Homo sapiens	106-109
30225069-4	2018	The XPS spectra showed that the prepared catalyst consisted of Bi, V, O, Ti and C. The photocatalytic activity of BiVO4/P25 was evaluated by degraded methyl blue (MB) and tetracycline under visible light illumination (lambda &gt; 420 nm), and the results showed that BiVO4/P25 composite has a better photocatalytic performance compared with pure BiVO4 and the most active c-BiVO4/P25 sample showed enough catalytic stability after three successive reuses for MB photodegradation.	tet	171-183	tubulin polymerization promoting protein	Homo sapiens	114-123
29951932-1	2018	Minocycline, an anti-infective agent of a tetracycline derivative, is reported to improve behavioral functional recovery after cerebral ischemia via enhancing the levels of brain-derived neurotrophic factor (BDNF).	tet	42-54	brain derived neurotrophic factor	Mus musculus	173-206
29951932-1	2018	Minocycline, an anti-infective agent of a tetracycline derivative, is reported to improve behavioral functional recovery after cerebral ischemia via enhancing the levels of brain-derived neurotrophic factor (BDNF).	tet	42-54	brain derived neurotrophic factor	Mus musculus	208-212
29723759-3	2018	Compared with Ag NPs deposited on the surface of SiO2@TiO2 (STA), the as-synthesized SAT exhibits a markedly enhanced visible-light and UV light activity than STA for degrading tetracycline and traditional dyes.	tet	177-189	GCY	Homo sapiens	60-63
29484827-5	2018	Polymerase chain reaction (PCR) was used to identify the tetracycline resistance determinants present within the bacterial communities of the WWTPs and receiving waters, and it was found that ARGs may not be released from the treatment process.	tet	57-69	serpin family A member 2 (gene/pseudogene)	Homo sapiens	192-196
30061508-0	2018	Assessment of Binding Interaction between Bovine Lactoferrin and Tetracycline Hydrochloride: Multi-Spectroscopic Analyses and Molecular Modeling.	tet	65-91	lactotransferrin	Bos taurus	49-60
30061508-1	2018	In this paper, the interaction between bovine lactoferrin (bLf) and tetracycline hydrochloride (TCH) was researched by microscale thermophoresis (MST), multi-spectroscopic methods, and molecular docking techniques.	tet	68-94	lactotransferrin	Bos taurus	46-57
30061508-1	2018	In this paper, the interaction between bovine lactoferrin (bLf) and tetracycline hydrochloride (TCH) was researched by microscale thermophoresis (MST), multi-spectroscopic methods, and molecular docking techniques.	tet	96-99	lactotransferrin	Bos taurus	46-57
29759239-3	2018	TC in diluted honey sample was adsorbed by the HMIP@CD within 3 min, after which the HMIP@CD absorbed with TC was separated by centrifugation from honey sample and redispersed into phosphate buffer solution.	tet	0-2	mitochondrial intermediate peptidase	Homo sapiens	47-63
29759239-3	2018	TC in diluted honey sample was adsorbed by the HMIP@CD within 3 min, after which the HMIP@CD absorbed with TC was separated by centrifugation from honey sample and redispersed into phosphate buffer solution.	tet	0-2	mitochondrial intermediate peptidase	Homo sapiens	47-51
29723759-3	2018	Compared with Ag NPs deposited on the surface of SiO2@TiO2 (STA), the as-synthesized SAT exhibits a markedly enhanced visible-light and UV light activity than STA for degrading tetracycline and traditional dyes.	tet	177-189	GCY	Homo sapiens	159-162
29600520-4	2018	The aim of this study was to demonstrate the limitation of tetracycline regulated gene expression by creating clonal cell lines expressing the wild-type or the mutant forms of Fat mass and obesity-associated protein.	tet	59-71	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	176-215
29697856-4	2018	Using transgenic mice in which expression of CXCL1 is under the control of a tetracycline-inducible promoter active within glial fibrillary acidic protein-positive cells, we have shown that sustained CXCL1 expression within the CNS increased the severity of clinical and histologic disease that was independent of an increase in the frequency of encephalitogenic Th1 and Th17 cells.	tet	77-89	chemokine (C-X-C motif) ligand 1	Mus musculus	45-50
29697856-4	2018	Using transgenic mice in which expression of CXCL1 is under the control of a tetracycline-inducible promoter active within glial fibrillary acidic protein-positive cells, we have shown that sustained CXCL1 expression within the CNS increased the severity of clinical and histologic disease that was independent of an increase in the frequency of encephalitogenic Th1 and Th17 cells.	tet	77-89	chemokine (C-X-C motif) ligand 1	Mus musculus	200-205
29697856-4	2018	Using transgenic mice in which expression of CXCL1 is under the control of a tetracycline-inducible promoter active within glial fibrillary acidic protein-positive cells, we have shown that sustained CXCL1 expression within the CNS increased the severity of clinical and histologic disease that was independent of an increase in the frequency of encephalitogenic Th1 and Th17 cells.	tet	77-89	negative elongation factor complex member C/D, Th1l	Mus musculus	363-366
29807909-0	2018	Differential Neurotoxicity Related to Tetracycline Transactivator and TDP-43 Expression in Conditional TDP-43 Mouse Model of Frontotemporal Lobar Degeneration.	tet	38-50	TAR DNA binding protein	Mus musculus	103-109
29807909-4	2018	tTA activates hTDP-43, which is placed downstream of the tetracycline response element.	tet	57-69	TAR DNA binding protein	Homo sapiens	14-21
29970878-4	2018	Here, we reported that knockdown of YY1 by lentivirus-mediated short hairpin RNA or tetracycline-inducible short hairpin RNA enhanced cisplatin-induced apoptosis and inhibition of cell proliferation, migration and invasion in the HNSCC cell lines, and inhibition of the xenograft tumor growth.	tet	84-96	YY1 transcription factor	Homo sapiens	36-39
29446321-4	2018	To induce IL-1beta expression in the pulmonary epithelium of mice with a tetracycline-inducible human IL-1beta transgene, doxycycline was administered via intraperitoneal injections to bitransgenic pups and their littermate controls on postnatal days (PN) 0, 0.5, and 1.	tet	73-85	interleukin 1 beta	Mus musculus	10-18
31940298-1	2018	INTRODUCTION: Resistance to ciprofloxacin and tetracycline is increasing in the food chain especially in E. coli strains and more worrisome will be occurrence of extended-spectrum beta-lactamase (ESBL) producers among ciprofloxacin- and tetracycline-resistant isolates.	tet	46-58	EsbL	Escherichia coli	162-194
31940298-1	2018	INTRODUCTION: Resistance to ciprofloxacin and tetracycline is increasing in the food chain especially in E. coli strains and more worrisome will be occurrence of extended-spectrum beta-lactamase (ESBL) producers among ciprofloxacin- and tetracycline-resistant isolates.	tet	237-249	EsbL	Escherichia coli	162-194
29446321-4	2018	To induce IL-1beta expression in the pulmonary epithelium of mice with a tetracycline-inducible human IL-1beta transgene, doxycycline was administered via intraperitoneal injections to bitransgenic pups and their littermate controls on postnatal days (PN) 0, 0.5, and 1.	tet	73-85	interleukin 1 beta	Homo sapiens	102-110
29559471-3	2018	Tetracycline-inducible downregulation of BCL-2 significantly sensitized MV4-11 and MOLM-13 AML cells to PI3K inhibition.	tet	0-12	BCL2 apoptosis regulator	Homo sapiens	41-46
29414091-0	2018	Label-free photoelectrochemical aptasensor for tetracycline detection based on cerium doped CdS sensitized BiYWO6.	tet	47-59	CDP-diacylglycerol synthase 1	Homo sapiens	92-95
29574648-10	2018	Graphical abstract Aqueous multiple photochemical behavior of dissociated tetracycline (TCH20, TCH-, and TC2-) is first comprehensively reported on revealing the phototransformation kinetics and implications for the fate in surface waters.	tet	74-86	transcobalamin 2	Homo sapiens	105-108
29102775-7	2018	RESULTS: An E. coli isolate belonging to ST167 was found to be positive for the blaNDM-1 gene and exhibited resistance to beta-lactams, tetracycline, gentamicin, fosfomycin and ciprofloxacin.	tet	136-148	NDM-1 metallo-beta-lactamase	Escherichia coli	80-88
29414091-5	2018	Thus, the G/BiYWO6/Ce:CdS heterostructure was successfully served as a matrix for the PEC detection of tetracycline (Tc) at 0 V (vs Hg/Hg2Cl2).	tet	103-115	CDP-diacylglycerol synthase 1	Homo sapiens	22-25
29414091-5	2018	Thus, the G/BiYWO6/Ce:CdS heterostructure was successfully served as a matrix for the PEC detection of tetracycline (Tc) at 0 V (vs Hg/Hg2Cl2).	tet	117-119	CDP-diacylglycerol synthase 1	Homo sapiens	22-25
29799025-4	2018	Here, we showed that overexpression of HBx by tetracycline-inducible systems further stabilized HIF-1alpha under hypoxia in HBV-negative HCC cell lines.	tet	46-58	X protein	Hepatitis B virus	39-42
29848341-10	2018	Moreover, tetracycline-inducible Pin1 knockdown and slow-releasing ATRA potently inhibited tumorigenicity of U937 and HL-60 leukemia cells in xenograft mouse models.	tet	10-22	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	33-37
29799025-4	2018	Here, we showed that overexpression of HBx by tetracycline-inducible systems further stabilized HIF-1alpha under hypoxia in HBV-negative HCC cell lines.	tet	46-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-106
29636110-11	2018	Likewise, the tetracycline-based antibiotic minocycline, which exhibits anti-inflammatory properties, was also effective in both inhibiting the TNF-alpha-induced MMP9 expression in M13SV1-Cre cells and blocking the TNF-alpha-induced fusion frequency of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells.	tet	14-26	tumor necrosis factor	Homo sapiens	144-153
29805766-2	2018	We developed a cell-mediated drug screening method to monitor NTCP expression on the cell surface by generating a HepG2 cell line with tetracycline-inducible expression of NTCP and a monoclonal antibody that specifically detects cell-surface NTCP.	tet	135-147	solute carrier family 10 member 1	Homo sapiens	62-66
29805766-2	2018	We developed a cell-mediated drug screening method to monitor NTCP expression on the cell surface by generating a HepG2 cell line with tetracycline-inducible expression of NTCP and a monoclonal antibody that specifically detects cell-surface NTCP.	tet	135-147	solute carrier family 10 member 1	Homo sapiens	172-176
29805766-2	2018	We developed a cell-mediated drug screening method to monitor NTCP expression on the cell surface by generating a HepG2 cell line with tetracycline-inducible expression of NTCP and a monoclonal antibody that specifically detects cell-surface NTCP.	tet	135-147	solute carrier family 10 member 1	Homo sapiens	172-176
29661834-5	2018	Further, in miR-132 knockout mice and in transgenic mice, where miR-132 is constitutively expressed under the control of the tetracycline regulator system, we found that time-of-day dependent memory recall (as assessed via novel object location and contextual fear conditioning paradigms) was suppressed.	tet	125-137	microRNA 132	Mus musculus	64-71
29567311-4	2018	Further optimizations of miR-21-T and its competing strand resulted in tetracycline-regulated on switches that induced luciferase expression by 19-fold in HeLa cells.	tet	71-83	microRNA 21	Homo sapiens	25-31
29516136-3	2018	The DNA aptamer of four tetracycline veterinary drugs was located at the sticky end of the HP1.	tet	24-36	chromobox 5	Homo sapiens	91-94
29636110-11	2018	Likewise, the tetracycline-based antibiotic minocycline, which exhibits anti-inflammatory properties, was also effective in both inhibiting the TNF-alpha-induced MMP9 expression in M13SV1-Cre cells and blocking the TNF-alpha-induced fusion frequency of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells.	tet	14-26	matrix metallopeptidase 9	Homo sapiens	162-166
29636110-11	2018	Likewise, the tetracycline-based antibiotic minocycline, which exhibits anti-inflammatory properties, was also effective in both inhibiting the TNF-alpha-induced MMP9 expression in M13SV1-Cre cells and blocking the TNF-alpha-induced fusion frequency of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells.	tet	14-26	tumor necrosis factor	Homo sapiens	215-224
29224189-4	2018	METHODS: Mice carrying loxP-flanked regions of Adipoq were generated and bred to the Adipoq (APN) promoter-driven reverse tetracycline-controlled transactivator (rtTA) (APN-rtTA) gene and a tet-responsive Cre line (TRE-Cre) to achieve acute depletion of APN.	tet	122-134	adiponectin, C1Q and collagen domain containing	Mus musculus	85-91
29224189-4	2018	METHODS: Mice carrying loxP-flanked regions of Adipoq were generated and bred to the Adipoq (APN) promoter-driven reverse tetracycline-controlled transactivator (rtTA) (APN-rtTA) gene and a tet-responsive Cre line (TRE-Cre) to achieve acute depletion of APN.	tet	122-134	adiponectin, C1Q and collagen domain containing	Mus musculus	93-96
29224189-4	2018	METHODS: Mice carrying loxP-flanked regions of Adipoq were generated and bred to the Adipoq (APN) promoter-driven reverse tetracycline-controlled transactivator (rtTA) (APN-rtTA) gene and a tet-responsive Cre line (TRE-Cre) to achieve acute depletion of APN.	tet	122-134	adiponectin, C1Q and collagen domain containing	Mus musculus	169-172
29224189-4	2018	METHODS: Mice carrying loxP-flanked regions of Adipoq were generated and bred to the Adipoq (APN) promoter-driven reverse tetracycline-controlled transactivator (rtTA) (APN-rtTA) gene and a tet-responsive Cre line (TRE-Cre) to achieve acute depletion of APN.	tet	122-134	adiponectin, C1Q and collagen domain containing	Mus musculus	169-172
29428849-1	2018	The human embryonic stem cell (hESC) line NERCe003-A-1 was generated by introducing lentiviral-vector-mediated tetracycline-inducible beta-catenin expression into a normal hESC line, NERCe003-A.	tet	111-123	catenin beta 1	Homo sapiens	134-146
28881470-5	2018	The photocatalyst presented a high photocatalytic activity (92%) at the optimum of CWLDH-3 and initial TC concentration of 40 mg L-1 .	tet	103-105	immunoglobulin kappa variable 1-16	Homo sapiens	129-132
29590189-9	2018	Our collection allows tetracycline-inducible expression of proteins with various tags suitable for protein localization, FRET, bimolecular fluorescence complementation (BiFC), protein dynamics studies (FRAP), co-immunoprecipitation, the RNA tethering assay and cell sorting.	tet	22-34	mechanistic target of rapamycin kinase	Homo sapiens	202-206
29538372-9	2018	To define the consequences of Dek overexpression in vivo, we generated and validated a tetracycline responsive Dek transgenic mouse model referred to as Bi-L-Dek.	tet	87-99	DEK proto-oncogene (DNA binding)	Mus musculus	111-114
29538372-9	2018	To define the consequences of Dek overexpression in vivo, we generated and validated a tetracycline responsive Dek transgenic mouse model referred to as Bi-L-Dek.	tet	87-99	DEK proto-oncogene (DNA binding)	Mus musculus	111-114
29180397-3	2018	To examine this possibility, we conditionally expressed APOL1-G0 (reference), -G1, and -G2 (variants) using a tetracycline-regulated system in HEK293 cells.	tet	110-122	apolipoprotein L1	Homo sapiens	56-61
29555934-5	2018	TC adsorption capacity onto E9D1 was higher than that onto E7D3 when the equilibrium concentration of TC exceeded 0.043 mmol/L because the electrostatic interaction between negatively charged groups of TC and protonated amines of adsorbents could compensate for the capacity loss resulting from BET surface area decrease.	tet	0-2	delta/notch like EGF repeat containing	Homo sapiens	295-298
29555934-5	2018	TC adsorption capacity onto E9D1 was higher than that onto E7D3 when the equilibrium concentration of TC exceeded 0.043 mmol/L because the electrostatic interaction between negatively charged groups of TC and protonated amines of adsorbents could compensate for the capacity loss resulting from BET surface area decrease.	tet	102-104	delta/notch like EGF repeat containing	Homo sapiens	295-298
29555934-5	2018	TC adsorption capacity onto E9D1 was higher than that onto E7D3 when the equilibrium concentration of TC exceeded 0.043 mmol/L because the electrostatic interaction between negatively charged groups of TC and protonated amines of adsorbents could compensate for the capacity loss resulting from BET surface area decrease.	tet	102-104	delta/notch like EGF repeat containing	Homo sapiens	295-298
29046167-6	2018	Tetracycline-inducible shRNA knockdown of NCAPG inhibits tumor growth of HCC cells in vivo.	tet	0-12	non-SMC condensin I complex subunit G	Homo sapiens	42-47
29673441-5	2018	U2-OS cells stably carrying a recombinant lentivirus expressing tetracycline-regulated TRIM21 were screened.	tet	64-76	tripartite motif containing 21	Homo sapiens	87-93
29136545-3	2018	The effects of pH (5, 7 and 9), initial TC concentration and competitive anions (NO3-, H2PO4-, SO42- and HCO3-) on the removal of TC by Fe/Ni BNPs were investigated.	tet	130-132	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
29136545-5	2018	The presence of NO3- greatly hindered the removal of TC, while the other anions (i.e., H2PO4-, SO42- and HCO3-) exhibited less inhibition.	tet	53-55	NBL1, DAN family BMP antagonist	Homo sapiens	16-19
29315578-10	2018	In order to clarify the contribution of HCN4 channels in the autonomic regulation of the SAN, we developed novel gain-of-function mutant mice in which the expression level of HCN4 channels could be reversibly changed from zero to ~3 times that in wild-type mice, using tetracycline transactivator and the tetracycline responsive element.	tet	269-281	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	Mus musculus	175-179
29315578-10	2018	In order to clarify the contribution of HCN4 channels in the autonomic regulation of the SAN, we developed novel gain-of-function mutant mice in which the expression level of HCN4 channels could be reversibly changed from zero to ~3 times that in wild-type mice, using tetracycline transactivator and the tetracycline responsive element.	tet	305-317	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	Mus musculus	175-179
29386392-3	2018	Here we develop human tyrosine hydroxylase (TH) promoter-controlled tetracycline-sensitive LRRK2 G2019S (GS) and LRRK2 G2019S kinase-dead (GS/DA) transgenic mice and show that LRRK2 GS expression leads to an age- and kinase-dependent cell-autonomous neurodegeneration of DA and norepinephrine (NE) neurons.	tet	68-80	tyrosine hydroxylase	Homo sapiens	22-42
29386392-3	2018	Here we develop human tyrosine hydroxylase (TH) promoter-controlled tetracycline-sensitive LRRK2 G2019S (GS) and LRRK2 G2019S kinase-dead (GS/DA) transgenic mice and show that LRRK2 GS expression leads to an age- and kinase-dependent cell-autonomous neurodegeneration of DA and norepinephrine (NE) neurons.	tet	68-80	leucine rich repeat kinase 2	Homo sapiens	91-96
29389871-0	2018	A Simple Surface-Enhanced Raman Spectroscopic Method for on-Site Screening of Tetracycline Residue in Whole Milk.	tet	78-90	Weaning weight-maternal milk	Bos taurus	108-112
29874776-1	2018	This study investigated the fate of tetracycline at four different concentrations of 20 mug L-1, 50 mug L-1, 2 and 5 mg L-1 in the enhanced biological nutrient removal processes.	tet	36-48	L1 cell adhesion molecule	Homo sapiens	92-116
29874776-1	2018	This study investigated the fate of tetracycline at four different concentrations of 20 mug L-1, 50 mug L-1, 2 and 5 mg L-1 in the enhanced biological nutrient removal processes.	tet	36-48	L1 cell adhesion molecule	Homo sapiens	92-95
29874776-2	2018	At the tetracycline concentration below 50 mug L-1, no obvious inhibition on the biological N&amp;P removal was observed, while the inhibition appeared after the tetracycline concentration was increased to 2 and 5 mg L-1.	tet	162-174	L1 cell adhesion molecule	Homo sapiens	217-220
29342444-8	2018	Streptococcal toxin encoding prophage phiHKU.vir and phiHKU.ssa in addition to the macrolide and tetracycline resistant ICE-emm12 and ICE-HKU397 elements were found amongst mainland China multi-clonal emm12 isolates suggesting a role in selection and expansion of scarlet fever lineages in China.	tet	97-109	carboxylesterase 2	Homo sapiens	120-123
29389871-10	2018	The peak intensities at 1285 and 1322 cm-1 were used to estimate the tetracycline concentrations in water and milk with correlation coefficients of 0.92 for water and 0.88 for milk.	tet	69-81	Weaning weight-maternal milk	Bos taurus	110-114
29389871-10	2018	The peak intensities at 1285 and 1322 cm-1 were used to estimate the tetracycline concentrations in water and milk with correlation coefficients of 0.92 for water and 0.88 for milk.	tet	69-81	Weaning weight-maternal milk	Bos taurus	176-180
29389871-3	2018	Milk expressed from treated cows before the withdrawal period has elapsed may contain tetracycline residue.	tet	86-98	Weaning weight-maternal milk	Bos taurus	0-4
29389871-4	2018	This study developed a simple surface-enhanced Raman spectroscopic (SERS) method for on-site screening of tetracycline residue in milk and water.	tet	106-118	Weaning weight-maternal milk	Bos taurus	130-134
29389871-6	2018	Milk-tetracycline and water-tetracycline solutions were prepared at seven concentration levels (1000, 500, 100, 10, 1, 0.1, and 0.01 ppm) and spiked with silver colloid nanoparticles.	tet	5-17	Weaning weight-maternal milk	Bos taurus	0-4
29389871-8	2018	Tetracycline vibrational modes were observed at 1285, 1317 and 1632 cm-1 in water-tetracycline solutions and 1322 and 1621 cm-1 (shifted from 1317 and 1632 cm-1, respectively) in milk-tetracycline solutions.	tet	0-12	Weaning weight-maternal milk	Bos taurus	179-183
29389871-8	2018	Tetracycline vibrational modes were observed at 1285, 1317 and 1632 cm-1 in water-tetracycline solutions and 1322 and 1621 cm-1 (shifted from 1317 and 1632 cm-1, respectively) in milk-tetracycline solutions.	tet	184-196	Weaning weight-maternal milk	Bos taurus	179-183
28860148-0	2018	Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits.	tet	47-59	plasminogen activator inhibitor 1	Oryctolagus cuniculus	10-43
29282319-4	2018	Here, we have developed a conditional tetracycline (Tet)-inducible animal model expressing the GalphasR201C in the skeletal stem cell (SSC) lineage (Tet-GalphasR201C/Prrx1-Cre/LSL-rtTA-IRES-GFP mice), which develops typical FD bone lesions in both embryos and adult mice in less than 2 weeks following doxycycline (Dox) administration.	tet	52-55	paired related homeobox 1	Mus musculus	166-171
29386360-5	2018	In line with these findings, tigecycline and two related antibiotics, tetracycline and doxycycline, synergized with venetoclax in killing human MYC/BCL2 DHL cells.	tet	70-82	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	144-147
29386360-5	2018	In line with these findings, tigecycline and two related antibiotics, tetracycline and doxycycline, synergized with venetoclax in killing human MYC/BCL2 DHL cells.	tet	70-82	BCL2 apoptosis regulator	Homo sapiens	148-152
29305867-7	2018	Increased NFAT activation with transcriptional activation of PICK1 during RAW264.7 osteoclastogenesis was also confirmed in a tetracycline-controlled PICK1 expression system.	tet	126-138	protein interacting with C kinase 1	Mus musculus	61-66
29305867-7	2018	Increased NFAT activation with transcriptional activation of PICK1 during RAW264.7 osteoclastogenesis was also confirmed in a tetracycline-controlled PICK1 expression system.	tet	126-138	protein interacting with C kinase 1	Mus musculus	150-155
28860148-1	2018	Elevated active plasminogen activator inhibitor-1 (PAI-1) has an adverse effect on the outcomes of intrapleural fibrinolytic therapy (IPFT) in tetracycline-induced pleural injury in rabbits.	tet	143-155	plasminogen activator inhibitor 1	Oryctolagus cuniculus	16-49
28860148-1	2018	Elevated active plasminogen activator inhibitor-1 (PAI-1) has an adverse effect on the outcomes of intrapleural fibrinolytic therapy (IPFT) in tetracycline-induced pleural injury in rabbits.	tet	143-155	plasminogen activator inhibitor 1	Oryctolagus cuniculus	51-56
28860148-9	2018	Thus, under conditions of slow (4-8 h) fibrinolysis in tetracycline-induced pleural injury in rabbits, only the inactivation of PAI-1, but not a decrease in the rate of its reaction with uPA, enhances IPFT.	tet	55-67	plasminogen activator inhibitor 1	Oryctolagus cuniculus	128-133
29073637-7	2018	However, we observed positive interactions between tetracycline use and adulthood UV exposure on SCC risk (P-interaction=0.05).	tet	51-63	serpin family B member 3	Homo sapiens	97-100
28987762-2	2018	Doxycycline (Dc) belongs to the tetracycline-class of antibiotics with demonstrated beneficial molecular effects in the brain and heart, mainly through matrix metalloproteinases inhibition (MMP).	tet	32-44	matrix metallopeptidase 2	Rattus norvegicus	190-193
29402834-4	2018	METHODS: Using tetracycline-inducible transgenic systems, we generated mice expressing GPR124 specifically under control of the Tie-2 promoter.	tet	15-27	adhesion G protein-coupled receptor A2	Mus musculus	87-93
29402834-4	2018	METHODS: Using tetracycline-inducible transgenic systems, we generated mice expressing GPR124 specifically under control of the Tie-2 promoter.	tet	15-27	TEK receptor tyrosine kinase	Mus musculus	128-133
29965398-3	2017	Tetracycline demonstrated the lowest concentration at 24.37 ng L-1.	tet	0-12	L1 cell adhesion molecule	Homo sapiens	63-66
29177651-2	2018	In order to study whether the members of the heat shock protein (HSP) families, by virtue of their molecular chaperone activity, can inhibit the formation of polyQ aggregates, we developed a cell culture model expressing the GFP tagged fragment of exon1 of the huntingtin gene with an expanded polyQ chain and tetracycline inducible chaperones.	tet	310-322	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	45-63
29177651-2	2018	In order to study whether the members of the heat shock protein (HSP) families, by virtue of their molecular chaperone activity, can inhibit the formation of polyQ aggregates, we developed a cell culture model expressing the GFP tagged fragment of exon1 of the huntingtin gene with an expanded polyQ chain and tetracycline inducible chaperones.	tet	310-322	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	65-68
29125995-7	2017	Previously, we reported a tetracycline-inducible MyoD overexpression model of myogenic differentiation using human iPSCs (hiPSCs).	tet	26-38	myogenic differentiation 1	Homo sapiens	49-53
29070872-5	2017	Analyses of tetracycline-inducible Baf53a conditional knockout ES cells revealed that the undifferentiated markers, including Nanog and Oct3/4, were expressed in Baf53a-deficient ES cells; however, growth of the cells was repressed, and expression of p53, p21, and cleaved Caspase 3 was increased.	tet	12-24	actin like 6A	Homo sapiens	35-41
28842345-6	2017	This effect paralleled that observed following temporally controlled, tetracycline-induced NeuroD1 overexpression.	tet	70-82	neuronal differentiation 1	Homo sapiens	91-98
29070872-5	2017	Analyses of tetracycline-inducible Baf53a conditional knockout ES cells revealed that the undifferentiated markers, including Nanog and Oct3/4, were expressed in Baf53a-deficient ES cells; however, growth of the cells was repressed, and expression of p53, p21, and cleaved Caspase 3 was increased.	tet	12-24	Nanog homeobox	Homo sapiens	126-131
29070872-5	2017	Analyses of tetracycline-inducible Baf53a conditional knockout ES cells revealed that the undifferentiated markers, including Nanog and Oct3/4, were expressed in Baf53a-deficient ES cells; however, growth of the cells was repressed, and expression of p53, p21, and cleaved Caspase 3 was increased.	tet	12-24	actin like 6A	Homo sapiens	162-168
28412568-8	2017	One MRSA CC398 (spa-type t899) isolate was detected (oxacillin MIC=32mg/L and mecA-positive), which presented resistance to penicillin, tetracycline, and ciprofloxacin and contained the genes of immune evasion cluster (IEC) system (type B).	tet	136-148	pulmonary surfactant-associated protein A	Sus scrofa	16-19
28800411-10	2017	The tetracycline resistance genes (tet(A), tet(B), tet(C), and tet(G) and sulfonamide resistance genes (sul1, sul2, and sul3) were identified in 84 (85.7%) and 89 (97.8%) antibiotic-resistant isolates respectively.	tet	4-16	dihydropteroate synthase type 1	Salmonella enterica subsp. enterica serovar Typhimurium	104-108
28800411-10	2017	The tetracycline resistance genes (tet(A), tet(B), tet(C), and tet(G) and sulfonamide resistance genes (sul1, sul2, and sul3) were identified in 84 (85.7%) and 89 (97.8%) antibiotic-resistant isolates respectively.	tet	4-16	dihydropteroate synthase 2	Salmonella enterica subsp. enterica serovar Typhimurium	110-114
29051615-3	2017	Nkcc1 transcription was blocked by the binding of a tetracycline-dependent transcriptional silencer to the tetracycline operator sequences inserted upstream of the Nkcc1 translation initiation site.	tet	52-64	solute carrier family 12, member 2	Mus musculus	0-5
29051615-3	2017	Nkcc1 transcription was blocked by the binding of a tetracycline-dependent transcriptional silencer to the tetracycline operator sequences inserted upstream of the Nkcc1 translation initiation site.	tet	52-64	solute carrier family 12, member 2	Mus musculus	164-169
29051615-3	2017	Nkcc1 transcription was blocked by the binding of a tetracycline-dependent transcriptional silencer to the tetracycline operator sequences inserted upstream of the Nkcc1 translation initiation site.	tet	107-119	solute carrier family 12, member 2	Mus musculus	0-5
29051615-3	2017	Nkcc1 transcription was blocked by the binding of a tetracycline-dependent transcriptional silencer to the tetracycline operator sequences inserted upstream of the Nkcc1 translation initiation site.	tet	107-119	solute carrier family 12, member 2	Mus musculus	164-169
29051615-4	2017	Administration of the tetracycline derivative doxycycline reversibly regulated Nkcc1 knockdown.	tet	22-34	solute carrier family 12, member 2	Mus musculus	79-84
28609726-1	2017	In this study, nano zero valent iron (NZVI) modified MCM-41-zeolite A (Fe-MCM-41-A) composite as a novel adsorbent was prepared by precipitation method and applied for tetracycline (TC) removal from aqueous solution.	tet	168-180	methylmalonyl-CoA mutase	Homo sapiens	53-56
28609726-1	2017	In this study, nano zero valent iron (NZVI) modified MCM-41-zeolite A (Fe-MCM-41-A) composite as a novel adsorbent was prepared by precipitation method and applied for tetracycline (TC) removal from aqueous solution.	tet	168-180	methylmalonyl-CoA mutase	Homo sapiens	74-77
28609726-0	2017	Removal of tetracycline from aqueous solution by MCM-41-zeolite A loaded nano zero valent iron: Synthesis, characteristic, adsorption performance and mechanism.	tet	11-23	methylmalonyl-CoA mutase	Homo sapiens	49-52
28609726-1	2017	In this study, nano zero valent iron (NZVI) modified MCM-41-zeolite A (Fe-MCM-41-A) composite as a novel adsorbent was prepared by precipitation method and applied for tetracycline (TC) removal from aqueous solution.	tet	182-184	methylmalonyl-CoA mutase	Homo sapiens	53-56
28609726-5	2017	Results showed that the optimal Fe-MCM-41-A dosage, initial pH and reaction time at initial TC concentration of 100mgL-1 solution are 1gL-1, pH=5, and 60 min respectively, at which the removal efficiency of TC was 98.7%.	tet	92-94	methylmalonyl-CoA mutase	Homo sapiens	35-38
28609726-5	2017	Results showed that the optimal Fe-MCM-41-A dosage, initial pH and reaction time at initial TC concentration of 100mgL-1 solution are 1gL-1, pH=5, and 60 min respectively, at which the removal efficiency of TC was 98.7%.	tet	92-94	LLGL scribble cell polarity complex component 1	Homo sapiens	115-120
28609726-5	2017	Results showed that the optimal Fe-MCM-41-A dosage, initial pH and reaction time at initial TC concentration of 100mgL-1 solution are 1gL-1, pH=5, and 60 min respectively, at which the removal efficiency of TC was 98.7%.	tet	207-209	methylmalonyl-CoA mutase	Homo sapiens	35-38
28609726-5	2017	Results showed that the optimal Fe-MCM-41-A dosage, initial pH and reaction time at initial TC concentration of 100mgL-1 solution are 1gL-1, pH=5, and 60 min respectively, at which the removal efficiency of TC was 98.7%.	tet	207-209	LLGL scribble cell polarity complex component 1	Homo sapiens	115-120
28609726-8	2017	This study demonstrates that Fe-MCM-41-A is a promising and efficient material for TC adsorption from aqueous solution.	tet	83-85	methylmalonyl-CoA mutase	Homo sapiens	32-35
28732909-9	2017	The TCH loaded into the optimized core-shell sample of TCMC 3% (w/v)/PEO 1% (w/v) had a smooth and beadless morphology with a diameter of 86.12nm, slow and sustained drug release, and excellent bactericidal activity against a wide range of bacteria.	tet	4-7	twinkle mtDNA helicase	Homo sapiens	69-75
28385546-3	2017	In cells expressing human OAT4 under the control of tetracycline, levocetirizine uptake was increased by tetracycline treatment.	tet	52-64	solute carrier family 22 member 11	Homo sapiens	26-30
28437230-4	2017	Different variants of bla, tet, flo, dfrA, and aadA genes were detected in most of the strains resistant to beta-lactam, tetracycline, chloramphenicol, sulfonamides, and aminoglycosides, respectively.	tet	121-133	beta-lactamase	Escherichia coli	22-25
28911317-3	2017	Mouse induced pluripotent stem (iPS) cell-derived cells were selected to stably express a tetracycline (Tet)-inducible bone morphogenic protein-4 (BMP4) expression cassette and a luciferase reporter driven by a hair-specific keratin 31 gene (krt31) promoter (Tet-BMP4-KRT31-Luc iPS).	tet	90-102	bone morphogenetic protein 4	Mus musculus	119-145
28911317-3	2017	Mouse induced pluripotent stem (iPS) cell-derived cells were selected to stably express a tetracycline (Tet)-inducible bone morphogenic protein-4 (BMP4) expression cassette and a luciferase reporter driven by a hair-specific keratin 31 gene (krt31) promoter (Tet-BMP4-KRT31-Luc iPS).	tet	90-102	bone morphogenetic protein 4	Mus musculus	147-151
28578197-9	2017	With increasing contents of antibiotics in soil the constant of chlorophyll degradation rate in lupin plants increased from k = 870 M-1day-1 for 3 mg ciprofloxacin to k = 2490 M-1day-1 for 90 mg ciprofloxacin, and in the case of tetracycline the reaction rate constant increased from k = 1330 M-1day-1 to k = 2910 M-1day-1.	tet	229-241	5'-nucleotidase, cytosolic IIIA	Homo sapiens	96-101
28385546-3	2017	In cells expressing human OAT4 under the control of tetracycline, levocetirizine uptake was increased by tetracycline treatment.	tet	105-117	solute carrier family 22 member 11	Homo sapiens	26-30
29100357-4	2017	By utilizing a tetracycline-regulated MYC transgene in a mouse T-ALL (EmuSRalpha-tTA;tet-o-MYC) and human Burkitt"s lymphoma (P493-6) model, we demonstrated that DNMT1 and DNMT3B expression depend on high MYC levels, and that their transcription decreased upon MYC-inactivation.	tet	15-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	38-41
28855541-2	2017	Here we describe compound genetically modified mice in which expression of the endogenous E2f3 gene may be either reversibly elevated or repressed in adult animals by oral administration of tetracycline.	tet	190-202	E2F transcription factor 3	Mus musculus	90-94
28874907-5	2017	In vitro synergistic effects were observed in combination of all three study pleuromutilins with tetracycline (TET) by standard checkerboard and/or time-kill assays.	tet	97-109	tetracycline-resistance protein	Staphylococcus aureus	111-114
28838350-0	2017	Molecular identification of drug resistant mutations to tetracycline in Mycoplasma spp.	tet	56-68	histocompatibility minor 13	Homo sapiens	83-86
28798382-5	2017	Here we take advantage of the leaky tetracycline promoter system in the Tat-transgenic mouse to show that a chronic very low-level expression of Tat is associated with astrocyte activation, inflammatory cytokine expression, ceramide accumulation, reductions in brain volume, synaptic, and axonal damage that occurs over a time frame of 1 year.	tet	36-48	tyrosine aminotransferase	Mus musculus	145-148
29100357-4	2017	By utilizing a tetracycline-regulated MYC transgene in a mouse T-ALL (EmuSRalpha-tTA;tet-o-MYC) and human Burkitt"s lymphoma (P493-6) model, we demonstrated that DNMT1 and DNMT3B expression depend on high MYC levels, and that their transcription decreased upon MYC-inactivation.	tet	15-27	DNA methyltransferase 3 beta	Homo sapiens	172-178
29100357-4	2017	By utilizing a tetracycline-regulated MYC transgene in a mouse T-ALL (EmuSRalpha-tTA;tet-o-MYC) and human Burkitt"s lymphoma (P493-6) model, we demonstrated that DNMT1 and DNMT3B expression depend on high MYC levels, and that their transcription decreased upon MYC-inactivation.	tet	15-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	91-94
29100357-4	2017	By utilizing a tetracycline-regulated MYC transgene in a mouse T-ALL (EmuSRalpha-tTA;tet-o-MYC) and human Burkitt"s lymphoma (P493-6) model, we demonstrated that DNMT1 and DNMT3B expression depend on high MYC levels, and that their transcription decreased upon MYC-inactivation.	tet	15-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	91-94
29100357-4	2017	By utilizing a tetracycline-regulated MYC transgene in a mouse T-ALL (EmuSRalpha-tTA;tet-o-MYC) and human Burkitt"s lymphoma (P493-6) model, we demonstrated that DNMT1 and DNMT3B expression depend on high MYC levels, and that their transcription decreased upon MYC-inactivation.	tet	15-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	91-94
29100357-4	2017	By utilizing a tetracycline-regulated MYC transgene in a mouse T-ALL (EmuSRalpha-tTA;tet-o-MYC) and human Burkitt"s lymphoma (P493-6) model, we demonstrated that DNMT1 and DNMT3B expression depend on high MYC levels, and that their transcription decreased upon MYC-inactivation.	tet	15-27	DNA methyltransferase 1	Homo sapiens	162-167
28576486-5	2017	Then, we developed an engineered stable cell line using a tetracycline-controlled inducible lentiviral system for the conditional expression of mutant eRF1, which can minimize the potential effect on normal translation termination.	tet	58-70	eukaryotic translation termination factor 1	Homo sapiens	151-155
28692326-3	2017	METHODS: The gene eIF2beta was cloned under tetracycline transcription control and the polylysine stretches were deleted by site-directed mutagenesis (eIF2betaDelta3K).	tet	44-56	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	18-26
28783087-8	2017	BET analysis showed a reduction in the free surface for both DOX@MIL-100 and TC@MIL-100.	tet	77-79	delta/notch like EGF repeat containing	Homo sapiens	0-3
28515174-3	2017	Here, we developed the use of polarized Madin-Darby canine kidney type I (MDCKI) mammalian epithelial cell lines with tetracycline-inducible human NCC expression to study NCC activity and membrane abundance in the same system.	tet	118-130	solute carrier family 12 member 3	Homo sapiens	147-150
28533357-4	2017	We generated Ras/Myc (RM9) and Myc-driven (Myc-CaP) prostate cancer cells expressing the tetracycline-inducible gene Tlr9 (Tlr9ON ) or the control LacZ (LacZON ).	tet	89-101	myelocytomatosis oncogene	Mus musculus	31-34
28369847-12	2017	CONCLUSIONS: Treatment with KI and/or its combination with tetracycline may be a useful treatment for PPP/PAO.	tet	59-71	spermine oxidase	Homo sapiens	102-109
28533357-7	2017	The PMN-MDSCs from tetracycline-treated RM9-Tlr9ON tumors increased the immunosuppressive activity of the STAT3 transcription factor, thereby more potently inhibiting T cell proliferation.	tet	19-31	toll-like receptor 9	Mus musculus	44-50
28533357-7	2017	The PMN-MDSCs from tetracycline-treated RM9-Tlr9ON tumors increased the immunosuppressive activity of the STAT3 transcription factor, thereby more potently inhibiting T cell proliferation.	tet	19-31	signal transducer and activator of transcription 3	Mus musculus	106-111
28533357-4	2017	We generated Ras/Myc (RM9) and Myc-driven (Myc-CaP) prostate cancer cells expressing the tetracycline-inducible gene Tlr9 (Tlr9ON ) or the control LacZ (LacZON ).	tet	89-101	myelocytomatosis oncogene	Mus musculus	31-34
28533357-4	2017	We generated Ras/Myc (RM9) and Myc-driven (Myc-CaP) prostate cancer cells expressing the tetracycline-inducible gene Tlr9 (Tlr9ON ) or the control LacZ (LacZON ).	tet	89-101	toll-like receptor 9	Mus musculus	117-121
28533357-4	2017	We generated Ras/Myc (RM9) and Myc-driven (Myc-CaP) prostate cancer cells expressing the tetracycline-inducible gene Tlr9 (Tlr9ON ) or the control LacZ (LacZON ).	tet	89-101	toll-like receptor 9	Mus musculus	123-129
28533357-5	2017	When engrafted into mice and treated with tetracycline, Tlr9ON , but not LacZON , tumors showed accelerated growth kinetics compared with tumors in PBS-treated mice.	tet	42-54	toll-like receptor 9	Mus musculus	56-62
28671703-7	2017	Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 can inhibit the proliferation and migration of bladder cancer cells.	tet	0-12	HOX transcript antisense RNA	Homo sapiens	46-52
28671703-7	2017	Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 can inhibit the proliferation and migration of bladder cancer cells.	tet	0-12	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	55-59
28671703-0	2017	Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 suppressed the progression of bladder cancer cells.	tet	0-12	HOX transcript antisense RNA	Homo sapiens	46-52
28472300-4	2017	Overexpression of RACK1 using a tetracycline-inducible lentivirus in mouse cortical collecting duct M1 cells stably expressing the rat MR and a Gaussia luciferase gene reporter under a hormone-response element promoter resulted in enhanced agonist-dependent MR transactivation.	tet	32-44	receptor for activated C kinase 1	Mus musculus	18-23
28671703-0	2017	Tetracycline-controllable artificial microRNA-HOTAIR + EZH2 suppressed the progression of bladder cancer cells.	tet	0-12	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	55-59
28671703-5	2017	Moreover, we used the technology of synthetic biology to construct the tetracycline-controllable artificial microRNA-HOTAIR + EZH2, which can decrease the expression of HOTAIR and EZH2 in a doxycycline dosage-dependent manner.	tet	71-83	HOX transcript antisense RNA	Homo sapiens	117-123
28671703-5	2017	Moreover, we used the technology of synthetic biology to construct the tetracycline-controllable artificial microRNA-HOTAIR + EZH2, which can decrease the expression of HOTAIR and EZH2 in a doxycycline dosage-dependent manner.	tet	71-83	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	126-130
28671703-5	2017	Moreover, we used the technology of synthetic biology to construct the tetracycline-controllable artificial microRNA-HOTAIR + EZH2, which can decrease the expression of HOTAIR and EZH2 in a doxycycline dosage-dependent manner.	tet	71-83	HOX transcript antisense RNA	Homo sapiens	169-175
28671703-5	2017	Moreover, we used the technology of synthetic biology to construct the tetracycline-controllable artificial microRNA-HOTAIR + EZH2, which can decrease the expression of HOTAIR and EZH2 in a doxycycline dosage-dependent manner.	tet	71-83	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	180-184
27865203-11	2017	The distinct ability of minocycline to modulate gene expressions of CXCL10 and CXCR3 makes it effective than doxycycline, a tetracycline used as chemoprophylaxis.	tet	124-136	chemokine (C-X-C motif) ligand 10	Mus musculus	68-74
28219741-4	2017	We constructed NTS-polyplex nanoparticles containing a single bifunctional plasmid that codes for the reverse tetracycline-controlled transactivator advanced (rtTA-Adv) under the control of NBRE3x promoter, and for hGDNF under the control of tetracycline-response element (TRE).	tet	110-122	neurotensin	Homo sapiens	15-18
28219741-4	2017	We constructed NTS-polyplex nanoparticles containing a single bifunctional plasmid that codes for the reverse tetracycline-controlled transactivator advanced (rtTA-Adv) under the control of NBRE3x promoter, and for hGDNF under the control of tetracycline-response element (TRE).	tet	242-254	neurotensin	Homo sapiens	15-18
28436019-24	2017	Moderate-quality evidence from a single study at low risk of bias suggested that a macrolide (azithromycin) may be more effective than a tetracycline (doxycycline) for curing mild-moderate PID.	tet	137-149	metastasis associated 1 family member 2	Homo sapiens	189-192
27463539-4	2017	Using a tetracycline-repressive transcriptional system and clonal mammary epithelial cells, SCp2, we found that the expression of cell surface syntaxin-4 elicits EMT-like cell behaviors.	tet	8-20	syntaxin 4	Homo sapiens	143-153
28183698-4	2017	In experiments originally designed to investigate the effect of premature Notch1 activation on the development of neural crest-derived olfactory ensheathing glial cells (OECs), we used in ovo electroporation to insert a tetracycline-inducible NotchDeltaE construct (encoding a constitutively active mutant of mouse Notch1) into the genome of chicken cranial neural crest cell precursors, and activated NotchDeltaE expression by doxycycline injection at embryonic day 4.	tet	220-232	notch 1	Mus musculus	315-321
28257106-6	2017	Furthermore, cell death and MMP synthesis and secretion can be prevented by tetracycline.	tet	76-88	matrix metallopeptidase 2	Homo sapiens	28-31
28181084-2	2017	The maximal adsorption capacity for Pb, Cd, and TC in a single adsorptive system calculated from Langmuir equation was 12.80, 85.20, and 42.94 mg L-1, while for mixed substances, the adsorption amount was 2.99, 13.46, and 20.89 mg L-1, respectively.	tet	48-50	L1 cell adhesion molecule	Homo sapiens	146-149
28181084-2	2017	The maximal adsorption capacity for Pb, Cd, and TC in a single adsorptive system calculated from Langmuir equation was 12.80, 85.20, and 42.94 mg L-1, while for mixed substances, the adsorption amount was 2.99, 13.46, and 20.89 mg L-1, respectively.	tet	48-50	L1 cell adhesion molecule	Homo sapiens	231-234
28055960-7	2017	To avoid potential confounding variables with use of tetracycline-inducible CA9 knockdown, we established CA9-ko and NHE1/CA9-dko cells.	tet	53-65	carbonic anhydrase 9	Homo sapiens	76-79
28274739-3	2017	Tetracycline exposure for 7 days effectively silenced TRAF3IP2 mRNA and Act1 protein, resulting in 761 genes with significant changes in expression (495 down, 266 up; &gt;1.5-fold, P &lt; 0.05).	tet	0-12	TRAF3 interacting protein 2	Homo sapiens	54-62
28274739-3	2017	Tetracycline exposure for 7 days effectively silenced TRAF3IP2 mRNA and Act1 protein, resulting in 761 genes with significant changes in expression (495 down, 266 up; &gt;1.5-fold, P &lt; 0.05).	tet	0-12	TRAF3 interacting protein 2	Homo sapiens	72-76
28702476-3	2017	We constructed two different tetracycline (tet)-on-based regulatable HSV vectors, one expressing NT-3 and the other expressing IL-10, in which the transactivator expression in the tet-on system was under the control of HSV latency-associated promoter 2 (LAP-2), and expression of the transgene was controlled by doxycycline (DOX).	tet	43-46	interleukin 10	Homo sapiens	127-132
28702476-3	2017	We constructed two different tetracycline (tet)-on-based regulatable HSV vectors, one expressing NT-3 and the other expressing IL-10, in which the transactivator expression in the tet-on system was under the control of HSV latency-associated promoter 2 (LAP-2), and expression of the transgene was controlled by doxycycline (DOX).	tet	43-46	thymopoietin	Homo sapiens	254-259
28218468-7	2017	At baseline, both the percent of PBMCs that were COPs (%COP) and COP cell-surface IGF-1R expression correlated directly with several histomorphometric indices of bone formation in tetracycline-labeled transiliac biopsies.	tet	180-192	insulin like growth factor 1 receptor	Homo sapiens	82-88
28552981-7	2017	Based on this, tetracycline has been predicted to impede the nucleotide-binding properties of EF-Tu.	tet	15-27	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	94-99
28552981-9	2017	Here, we report a fluorescence-based kinetic assay that minimizes the effect of tetracycline autofluorescence, enabling the detailed kinetic analysis of the nucleotide-binding properties of Escherichia coli EF-Tu.	tet	80-92	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	207-212
28407733-3	2017	We engineered HT22 cells to express a Klf9 transgene under control of the tetracycline repressor, and used RNA sequencing to identify genes modulated by Klf9.	tet	74-86	Kruppel-like factor 9	Mus musculus	38-42
28395715-1	2017	Objective To investigate the effect of CDKN2A/p16INK4a, a cyclin-dependent kinase inhibitor, on cell morphology and cytoskeleton in MCF7 breast cancer cells by tetracycline operon (Tet-on) inducible gene expression system.	tet	160-172	cyclin dependent kinase inhibitor 2A	Homo sapiens	39-45
28395715-1	2017	Objective To investigate the effect of CDKN2A/p16INK4a, a cyclin-dependent kinase inhibitor, on cell morphology and cytoskeleton in MCF7 breast cancer cells by tetracycline operon (Tet-on) inducible gene expression system.	tet	160-172	cyclin dependent kinase inhibitor 2A	Homo sapiens	46-54
28088753-3	2017	METHODS AND RESULTS: We have recently generated binary (Tet-ON/OFF) conditional transgenic mice (Tet-Nox2:VE-Cad-tTA) that can induce 1.8 +- 0.42-fold increase in NADPH oxidase (NOX)-derived ROS specifically in vascular endothelium upon withdrawal of tetracycline from the drinking water.	tet	251-263	cytochrome b-245, beta polypeptide	Mus musculus	101-105
28088753-3	2017	METHODS AND RESULTS: We have recently generated binary (Tet-ON/OFF) conditional transgenic mice (Tet-Nox2:VE-Cad-tTA) that can induce 1.8 +- 0.42-fold increase in NADPH oxidase (NOX)-derived ROS specifically in vascular endothelium upon withdrawal of tetracycline from the drinking water.	tet	251-263	cadherin 5	Mus musculus	106-112
27916494-3	2017	The removal efficiency values for tetracycline (200 mg L-1) were 31.5% and 97.8%, respectively, by the biochar-Cu NP composite (0.5 g L-1) in the absence and presence of hydrogen peroxide (H2O2, 20 mM) within 6 h of reaction time.	tet	34-46	L1 cell adhesion molecule	Homo sapiens	55-58
27916494-3	2017	The removal efficiency values for tetracycline (200 mg L-1) were 31.5% and 97.8%, respectively, by the biochar-Cu NP composite (0.5 g L-1) in the absence and presence of hydrogen peroxide (H2O2, 20 mM) within 6 h of reaction time.	tet	34-46	L1 cell adhesion molecule	Homo sapiens	134-137
28003335-3	2017	Moreover, a better response to EGFR-TKI was associated with low RHOB levels in a panel of lung tumor cell lines and in a lung-specific tetracycline-inducible EGFRL858R transgenic mouse model.	tet	135-147	epidermal growth factor receptor	Homo sapiens	31-35
27566885-9	2017	Co-located resistance to sulfonamides, tetracycline, trimethoprim, and chloramphenicol/florfenicol was detected on five ESBL gene-carrying plasmids, but seven plasmids conferred solely resistance to beta-lactam antibiotics.	tet	39-51	EsbL	Escherichia coli	120-124
25047146-6	2017	hTERT-CTLA4Ig hBMSCs retained their capacity for osteogenic differentiation in vitro, shown by the detection of hydroxyapatite mineral deposition (labelled tetracycline fluorescence staining), calcareous nodules (alizarin red S staining), alkaline phosphatase (calcium-cobalt method) and osteocalcin (immunocytochemistry).	tet	156-168	telomerase reverse transcriptase	Homo sapiens	0-5
28271033-3	2017	METHODS: Here, we have developed transgenic mice that overexpress AdipoR1 or AdipoR2 under the inducible control of a tetracycline response element.	tet	118-130	adiponectin receptor 1	Mus musculus	66-73
28271033-3	2017	METHODS: Here, we have developed transgenic mice that overexpress AdipoR1 or AdipoR2 under the inducible control of a tetracycline response element.	tet	118-130	adiponectin receptor 2	Mus musculus	77-84
28245965-9	2017	Analysis of resistance determinants in S. enterica strains (n=33) revealed that the resistance to beta-lactam antibiotics, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline, was attributed to the presence of carb-like, dfrA1, floR, tetA gene, respectively.	tet	175-187	FloR	Salmonella enterica	241-245
28049944-3	2017	To control the secretion of MDA-7 from MSCs, a well-established tetracycline-controlled transcriptional activation system was incorporated into MDA-7 plasmid.	tet	64-76	interleukin 24	Homo sapiens	28-33
28049944-3	2017	To control the secretion of MDA-7 from MSCs, a well-established tetracycline-controlled transcriptional activation system was incorporated into MDA-7 plasmid.	tet	64-76	interleukin 24	Homo sapiens	144-149
27865873-5	2017	In tetracycline-induced Flp-In T-Rex-293 cells, GPR87 induced cell clustering presumably through Galpha12/13 coupling.	tet	3-15	G protein-coupled receptor 87	Homo sapiens	48-53
27865873-5	2017	In tetracycline-induced Flp-In T-Rex-293 cells, GPR87 induced cell clustering presumably through Galpha12/13 coupling.	tet	3-15	G protein subunit alpha 12	Homo sapiens	97-105
28558368-4	2017	METHODS: The mouse breast cancer cell line 4T1 was transfected with an inducible, bidirectional tetracycline (Bi-Tet) promoter driving VEGF and renilla luciferase (Rluc).	tet	96-108	vascular endothelial growth factor A	Mus musculus	135-139
27704165-3	2017	METHODS: Diabetes was induced by tetracycline-inducible small hairpin RNA (shRNA) knockdown of the insulin receptor in rats, generating TetO rats.	tet	33-45	insulin receptor	Rattus norvegicus	99-115
28184339-9	2017	The statistical analysis showed that the esp infective gene has significant associations with ciprofloxacin, erythromycin and tetracycline in E. faecium and with chloramphenicol in E. faecalis strains; the hyl with teicoplanin and vancomycin in E. faecium strains; and also asa1 with vancomycin in E. faecium and with ampicillin and chloramphenicol in E. faecalis strains.	tet	126-138	aggregation substance	Enterococcus faecalis	274-278
27916622-2	2017	Here we report the identification, in clinical Salmonella Typhimurium strains, of an IncQ1 plasmid (pNUC) which confers resistance to sulfamethoxazole, streptomycin and tetracycline through the presence of sul2, strAB and tetA genes, respectively.	tet	169-181	dihydropteroate synthase 2	Salmonella enterica subsp. enterica serovar Typhimurium	206-210
28024479-12	2016	Tetracycline induced its expression for 48 h and 72 h. pTER117, pTER363 decreased the mRNA level of BCR/ABL 90%, 82% and 91.5%, 84%, respectively, P210 protein were almost measured in K562 cells.	tet	0-12	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	100-107
27642093-4	2017	To understand the molecular mechanisms that govern the receptor-ligand interactions, we overexpressed the human OR hOR1A1 in a stable tetracycline-inducible HEK293S cell line.	tet	134-146	olfactory receptor family 1 subfamily A member 1	Homo sapiens	115-121
28035227-1	2016	INTRODUCTION: One of two main mechanisms of resistance in tetracycline-resistant Neisseria gonorrhoeae (TRNG) is associated with the presence of TetM protein responsible for actively blocking of the tetracycline target site in the 30S ribosomal subunit.	tet	58-70	TetM	Neisseria gonorrhoeae	145-149
28035227-1	2016	INTRODUCTION: One of two main mechanisms of resistance in tetracycline-resistant Neisseria gonorrhoeae (TRNG) is associated with the presence of TetM protein responsible for actively blocking of the tetracycline target site in the 30S ribosomal subunit.	tet	199-211	TetM	Neisseria gonorrhoeae	145-149
28584529-0	2017	hTERT-Immortalized Bone Mesenchymal Stromal Cells Expressing Rat Galanin via a Single Tetracycline-Inducible Lentivirus System.	tet	86-98	telomerase reverse transcriptase	Homo sapiens	0-5
28584529-0	2017	hTERT-Immortalized Bone Mesenchymal Stromal Cells Expressing Rat Galanin via a Single Tetracycline-Inducible Lentivirus System.	tet	86-98	galanin and GMAP prepropeptide	Homo sapiens	65-72
27342876-3	2016	We took advantage of the unique binding of murine VEGF-D specifically to VEGFR-3 and generated mice capable of inducible, tissue-specific expression of murine VEGF-D under a tightly-controlled tetracycline response element (TRE) promoter to stimulate adult tissue lymphangiogenesis.	tet	193-205	vascular endothelial growth factor D	Mus musculus	50-56
27732942-5	2016	Constitutive or aberrant activation of NF-kappaB is encountered in many types of cancer, including CTCL.Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-kappaB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-kappaB pathway.	tet	237-249	nuclear factor kappa B subunit 1	Homo sapiens	39-48
27732942-5	2016	Constitutive or aberrant activation of NF-kappaB is encountered in many types of cancer, including CTCL.Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-kappaB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-kappaB pathway.	tet	237-249	TSPY like 2	Homo sapiens	99-103
27732942-5	2016	Constitutive or aberrant activation of NF-kappaB is encountered in many types of cancer, including CTCL.Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-kappaB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-kappaB pathway.	tet	237-249	nuclear factor kappa B subunit 1	Homo sapiens	208-217
27732942-5	2016	Constitutive or aberrant activation of NF-kappaB is encountered in many types of cancer, including CTCL.Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-kappaB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-kappaB pathway.	tet	237-249	nuclear factor kappa B subunit 1	Homo sapiens	208-217
27434171-8	2016	The limits of detection (LOD) are determined, with high precision, to 6.33 and 9.22 ng mL-1 for tetracycline and pristinamycin, respectively.	tet	96-108	L1 cell adhesion molecule	Mus musculus	87-91
27752996-4	2016	A tetracycline-regulated TrkB-expressing NB cell line (TB3) was used.	tet	2-14	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	25-29
27698449-7	2016	A tetracycline-inducible lentiviral expression system containing shRNA to p53 was used to knockout p53.	tet	2-14	tumor protein p53	Homo sapiens	74-77
27698449-7	2016	A tetracycline-inducible lentiviral expression system containing shRNA to p53 was used to knockout p53.	tet	2-14	tumor protein p53	Homo sapiens	99-102
26866925-5	2016	We studied the course of infection in stably-transfected murine macrophages (RAW264.7) bearing a tetracycline-inducible plasmid producing hmox shRNA and in primary HO-1 knockout macrophages.	tet	97-109	heme oxygenase 1	Mus musculus	138-142
27457352-6	2016	In order to examine whether DNA demethylation affects the growth of cancer cells, we have established a tetracycline inducible system that can regulate the expression of MBD-TET1-CDwt in a prostate cancer cell line, LNCaP.	tet	104-116	tet methylcytosine dioxygenase 1	Homo sapiens	174-178
27819668-5	2016	We further confirmed the inhibitory effects of SALL4 knockdown on gastric cancer cells by using a tetracycline-inducible system.	tet	98-110	spalt like transcription factor 4	Homo sapiens	47-52
27673450-8	2016	When ASPL-TFE3 was expressed in human bone marrow-derived mesenchymal stem cells in a tetracycline-inducible manner, we observed the up-regulation of p21 expression and the induction of senescence-associated beta-galactosidase activity.	tet	86-98	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	5-9
27673450-8	2016	When ASPL-TFE3 was expressed in human bone marrow-derived mesenchymal stem cells in a tetracycline-inducible manner, we observed the up-regulation of p21 expression and the induction of senescence-associated beta-galactosidase activity.	tet	86-98	transcription factor binding to IGHM enhancer 3	Homo sapiens	10-14
27673450-8	2016	When ASPL-TFE3 was expressed in human bone marrow-derived mesenchymal stem cells in a tetracycline-inducible manner, we observed the up-regulation of p21 expression and the induction of senescence-associated beta-galactosidase activity.	tet	86-98	H3 histone pseudogene 16	Homo sapiens	150-153
27673450-8	2016	When ASPL-TFE3 was expressed in human bone marrow-derived mesenchymal stem cells in a tetracycline-inducible manner, we observed the up-regulation of p21 expression and the induction of senescence-associated beta-galactosidase activity.	tet	86-98	galactosidase beta 1	Homo sapiens	208-226
27383683-1	2016	Previous transcriptome analyses have suggested that a gene cluster including a transcriptional regulator (blr7984) of the tetracycline repressor family was markedly down-regulated in symbiosis.	tet	122-134	TetR/AcrR family transcriptional regulator	Bradyrhizobium diazoefficiens USDA 110	106-113
27593210-4	2016	We designed a tetracycline-regulated transgene construct in which the cDNA for human tau was fused to ubiquitin and to luciferase to create a single fusion polyprotein, termed TUL.	tet	14-26	microtubule associated protein tau	Homo sapiens	85-88
27552991-5	2016	RESULTS: A tetracycline-inducible TF-1 erythroleukemia cell line was transduced with retroviruses to create cell lines expressing HA-tagged wildtype SRSF2, SRSF2 with proline 95 point mutations found in MDS, or SRSF2 with a deletion of one of the four major domains of the protein.	tet	11-23	serine and arginine rich splicing factor 2	Homo sapiens	149-154
27552991-5	2016	RESULTS: A tetracycline-inducible TF-1 erythroleukemia cell line was transduced with retroviruses to create cell lines expressing HA-tagged wildtype SRSF2, SRSF2 with proline 95 point mutations found in MDS, or SRSF2 with a deletion of one of the four major domains of the protein.	tet	11-23	serine and arginine rich splicing factor 2	Homo sapiens	156-161
27552991-5	2016	RESULTS: A tetracycline-inducible TF-1 erythroleukemia cell line was transduced with retroviruses to create cell lines expressing HA-tagged wildtype SRSF2, SRSF2 with proline 95 point mutations found in MDS, or SRSF2 with a deletion of one of the four major domains of the protein.	tet	11-23	serine and arginine rich splicing factor 2	Homo sapiens	156-161
27342876-3	2016	We took advantage of the unique binding of murine VEGF-D specifically to VEGFR-3 and generated mice capable of inducible, tissue-specific expression of murine VEGF-D under a tightly-controlled tetracycline response element (TRE) promoter to stimulate adult tissue lymphangiogenesis.	tet	193-205	vascular endothelial growth factor D	Mus musculus	159-165
27356744-8	2016	Conversely, tetracycline-inducible expression of ARF increases MMP7 with a decrease of E-Cadherin in PCa cells.	tet	12-24	matrix metallopeptidase 7	Homo sapiens	63-67
27197997-6	2016	Activation of CAR and PXR in cells treated with a high dose of CITCO [6-(4-chlorophenyl)-imidazo(2,1-b)thiazole-5-carbaldehyde] or cotreated with rifampicin and tetracycline resulted in synergistic enhancement of CYP3A4, but not CYP2B6, CYP2C9, or UGT1A1, mRNA expression in HepTR/hCAR/hPXR cells.	tet	161-173	nuclear receptor subfamily 1 group I member 3	Homo sapiens	14-17
27197997-6	2016	Activation of CAR and PXR in cells treated with a high dose of CITCO [6-(4-chlorophenyl)-imidazo(2,1-b)thiazole-5-carbaldehyde] or cotreated with rifampicin and tetracycline resulted in synergistic enhancement of CYP3A4, but not CYP2B6, CYP2C9, or UGT1A1, mRNA expression in HepTR/hCAR/hPXR cells.	tet	161-173	nuclear receptor subfamily 1 group I member 2	Homo sapiens	22-25
27071938-0	2016	Reversible immortalization of sheep fetal fibroblast cells by tetracycline-inducible expression of human telomerase reverse transcriptase.	tet	62-74	telomerase reverse transcriptase	Homo sapiens	105-137
27071938-1	2016	OBJECTIVES: To achieve reversible immortalization of cells, we design a modified tetracycline-inducible expression (Tet-on) system to conditionally regulate the ectopic expression of human telomerase reverse transcriptase (hTERT) in primary cells.	tet	81-93	telomerase reverse transcriptase	Homo sapiens	189-221
27071938-1	2016	OBJECTIVES: To achieve reversible immortalization of cells, we design a modified tetracycline-inducible expression (Tet-on) system to conditionally regulate the ectopic expression of human telomerase reverse transcriptase (hTERT) in primary cells.	tet	81-93	telomerase reverse transcriptase	Homo sapiens	223-228
27197997-4	2016	Here, we established a tetracycline-inducible human CAR and stably human PXR-overexpressing HepG2 cell line (HepTR/hCAR/hPXR) to examine CAR/PXR dual ligands.	tet	23-35	nuclear receptor subfamily 1 group I member 3	Homo sapiens	52-55
27356744-8	2016	Conversely, tetracycline-inducible expression of ARF increases MMP7 with a decrease of E-Cadherin in PCa cells.	tet	12-24	cadherin 1	Homo sapiens	87-97
27328915-0	2016	Synthetic tetracycline-controllable shRNA targeting long non-coding RNA HOXD-AS1 inhibits the progression of bladder cancer.	tet	10-22	HOXD antisense growth-associated long non-coding RNA	Homo sapiens	72-80
27111147-5	2016	Here, we used two synthetic gene circuits inducible by tetracycline family molecules to regulate the expression of a yeast ABC pump (Pdr5p) that pumps out the inducer.	tet	55-67	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	133-138
27462521-0	2016	Insights into the interactions between tetracycline, its degradation products and bovine serum albumin.	tet	39-51	albumin	Homo sapiens	89-102
27462521-3	2016	We studied bovine serum albumin (BSA) (a functional protein) as a target of tetracycline-induced toxicity by examining its interactions with TC, anhydrotetracycline (ATC) and epitetracycline (ETC), based on a fluorescence spectroscopy and molecular docking method under simulated physiological conditions.	tet	76-88	albumin	Homo sapiens	18-31
27462521-3	2016	We studied bovine serum albumin (BSA) (a functional protein) as a target of tetracycline-induced toxicity by examining its interactions with TC, anhydrotetracycline (ATC) and epitetracycline (ETC), based on a fluorescence spectroscopy and molecular docking method under simulated physiological conditions.	tet	141-143	albumin	Homo sapiens	18-31
27367005-11	2016	Both ESBL producers and non-producers had high resistance to ampicillin followed by trimethoprim-sulphamethoxazole, third-generation cephalosporins, and tetracycline.	tet	153-165	EsbL	Escherichia coli	5-9
27018306-0	2016	Tetracycline-inducible shRNA targeting antisense long non-coding RNA HIF1A-AS2 represses the malignant phenotypes of bladder cancer.	tet	0-12	HIF1A antisense RNA 2	Homo sapiens	69-78
27018306-7	2016	Besides, we utilized the emerging technology of medical synthetic biology to design tetracycline-inducible small hairpin RNA (shRNA) vector which specifically silenced HIF1A-AS2 in a dosage-dependent manner to inhibit the progression of human bladder cancer.	tet	84-96	HIF1A antisense RNA 2	Homo sapiens	168-177
27018306-9	2016	Synthetic "tetracycline-on" switch system that quantitatively controlled the expression of HIF1A-AS2 in bladder cancer can inhibit the progression of bladder cancer cells in a dosage-dependent manner.	tet	11-23	HIF1A antisense RNA 2	Homo sapiens	91-100
27188318-5	2016	Furthermore, the recoveries of tetracycline (70 muM) from BSA (133 mug/mL) and FBS (0.66 ppt) by the APS-modified glass were 98% (RSD = 3.5%, n = 5) and 97% (RSD = 5.7%), respectively.	tet	31-43	latexin	Homo sapiens	48-51
27328915-5	2016	METHODS: The synthetic tetracycline-controllable shRNA was used to modulate the level of HOXD-AS1 by adding different concentrations of doxycycline (dox).	tet	23-35	HOXD antisense growth-associated long non-coding RNA	Homo sapiens	89-97
27328915-13	2016	At last, we used the important element of synthetic biology, tetracycline(tet)-controllable switch, to construct tet-controllable shRNA vectors which can modulate the expression of HOXD-AS1 in a dosage-dependent manner.	tet	61-73	HOXD antisense growth-associated long non-coding RNA	Homo sapiens	181-189
27270236-6	2016	We have shown here for the first time that the tetracycline antibiotic, minocycline, administered to HIV-infected individuals reduces plasma levels of soluble CD40L and platelet factor 4 levels, host molecules predominately released by platelets.	tet	47-59	CD40 ligand	Homo sapiens	159-164
27267601-13	2016	The resistance rates to ampicillin and tetracycline in Salmonella spp.	tet	39-51	histocompatibility minor 13	Homo sapiens	66-69
27270547-10	2016	Topical TET significantly reduced the serum level of TSLP (119.04 +- 38.92 pg/ml vs. 65.95 +- 54.61 pg/ml, P = 0.011) and both mRNA and protein expressions of TSLP in skin lesions compared with AD group (P = 0.003 and 0.011, respectively), and NF-kappaB and PAR2 expression in skin lesions were also suppressed (P = 0.016 and 0.040, respectively).	tet	8-11	thymic stromal lymphopoietin	Mus musculus	53-57
27270547-10	2016	Topical TET significantly reduced the serum level of TSLP (119.04 +- 38.92 pg/ml vs. 65.95 +- 54.61 pg/ml, P = 0.011) and both mRNA and protein expressions of TSLP in skin lesions compared with AD group (P = 0.003 and 0.011, respectively), and NF-kappaB and PAR2 expression in skin lesions were also suppressed (P = 0.016 and 0.040, respectively).	tet	8-11	thymic stromal lymphopoietin	Mus musculus	159-163
27270547-10	2016	Topical TET significantly reduced the serum level of TSLP (119.04 +- 38.92 pg/ml vs. 65.95 +- 54.61 pg/ml, P = 0.011) and both mRNA and protein expressions of TSLP in skin lesions compared with AD group (P = 0.003 and 0.011, respectively), and NF-kappaB and PAR2 expression in skin lesions were also suppressed (P = 0.016 and 0.040, respectively).	tet	8-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	244-253
27270547-10	2016	Topical TET significantly reduced the serum level of TSLP (119.04 +- 38.92 pg/ml vs. 65.95 +- 54.61 pg/ml, P = 0.011) and both mRNA and protein expressions of TSLP in skin lesions compared with AD group (P = 0.003 and 0.011, respectively), and NF-kappaB and PAR2 expression in skin lesions were also suppressed (P = 0.016 and 0.040, respectively).	tet	8-11	coagulation factor II (thrombin) receptor-like 1	Mus musculus	258-262
27270547-11	2016	Furthermore, expressions of inflammatory cytokines IL-4, IL-13, and TNF-alpha in skin lesions were down-regulated in 2% TET group compared with AD group (P = 0.035, 0.008, and 0.044, respectively).	tet	120-123	interleukin 4	Mus musculus	51-55
27270547-11	2016	Furthermore, expressions of inflammatory cytokines IL-4, IL-13, and TNF-alpha in skin lesions were down-regulated in 2% TET group compared with AD group (P = 0.035, 0.008, and 0.044, respectively).	tet	120-123	interleukin 13	Mus musculus	57-62
27270547-11	2016	Furthermore, expressions of inflammatory cytokines IL-4, IL-13, and TNF-alpha in skin lesions were down-regulated in 2% TET group compared with AD group (P = 0.035, 0.008, and 0.044, respectively).	tet	120-123	tumor necrosis factor	Mus musculus	68-77
27270547-12	2016	CONCLUSIONS: Topical TET exerted anti-inflammatory effects through suppression of TSLP and inflammatory cytokines in AD mouse model, suggesting TET as a potential agent for the topical treatment of AD in the future.	tet	21-24	thymic stromal lymphopoietin	Mus musculus	82-86
27300437-3	2016	Thirty percent of mice developed monoclonal B cell leukemia, which was prevented or regressed when a tetracycline-repressible miRNA-126 cassette was switched off.	tet	101-113	microRNA 126	Homo sapiens	126-135
27015551-0	2016	shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells.	tet	56-68	colon cancer associated transcript 2	Homo sapiens	36-41
27056322-3	2016	The herpes simplex type 1-thymidine kinase (TK) actively kills dividing tumor cells in the brain when in the presence of the prodrug, ganciclovir (GCV), whereas the FMS-like tyrosine kinase 3 ligand (Flt3L) is an immune-stimulatory molecule under tight regulation by a tetracycline-inducible "Tet-On" activation system that induces anti-GBM immunity.	tet	269-281	fms related receptor tyrosine kinase 3 ligand	Homo sapiens	165-198
27090639-5	2016	Growth suppression of nude mouse xenograft tumors carrying a tetracycline-inducible vector system was observed with the addition of doxycycline in drinking water, confirming that the cystatin E/M gene is a tumor suppressor gene.	tet	61-73	cystatin E/M	Homo sapiens	183-193
27015551-5	2016	Besides, using the post-transcriptional device of synthetic biology, we create the tetracycline-inducible double small hairpin RNAs (shRNAs) vector to control the expression level of CCAT2 which was induced by doxycycline in a dosage-dependent manner.	tet	83-95	colon cancer associated transcript 2	Homo sapiens	183-188
27015551-7	2016	The expression of CCAT2 can be quantitatively controlled by the synthetic "tetracycline-on" switch system in bladder cancer in response to different concentrations of doxycycline to inhibit the development of bladder cancer cells.	tet	75-87	colon cancer associated transcript 2	Homo sapiens	18-23
28773486-5	2016	Moreover, pH had little effect on the removal of tetracycline, and the electrocatalytic membrane could effectively remove tetracycline with initial concentration of 50 mg L-1 (pH, 3.8-9.6).	tet	122-134	L1 cell adhesion molecule	Homo sapiens	171-174
28773486-6	2016	The 100% tetracycline and 87.8% COD removal rate could be achieved under the following operating conditions: tetracycline concentration of 50 mg L-1, current density of 1 mA cm-2, temperature of 25  C, and residence time of 4.4 min.	tet	109-121	L1 cell adhesion molecule	Homo sapiens	145-148
27126938-2	2016	METHODS: A human colorectal cancer cell line with tetracycline-inducible expression regulatory system, namely SW620/Tet-on, was established; inducible expression lentiviral vector with artificial microRNA targeting PAR4, pLVX-Tight-Puro-PAR4-miR, was constructed and transfected into SW620/Tet-on to make an inducible PAR4-suppressed cell model SW620/PAR4D.	tet	50-62	F2R like thrombin or trypsin receptor 3	Homo sapiens	215-219
26999031-12	2016	There was a 2-fold increased risk of Parkinson disease in patients classified as having ocular rosacea (adjusted IRR, 2.03 [95% CI, 1.67-2.48]), and tetracycline therapy appeared to reduce the risk of Parkinson disease (adjusted IRR, 0.98 [95% CI, 0.97-0.99]).	tet	149-161	insulin receptor related receptor	Homo sapiens	229-232
26806540-2	2016	The human TRPA1 was expressed in HEK293T cells using a tetracycline-inducible system.	tet	55-67	transient receptor potential cation channel subfamily A member 1	Homo sapiens	10-15
26892043-5	2016	We examined the role of PR-PPD in cell proliferation and signaling by stably expressing PR-B, or PR-B with disrupting mutations in the PPD (PR-BDeltaSH3), from a tetracycline-regulated promoter in A549 NSCLC cells.	tet	162-174	progesterone receptor	Homo sapiens	24-26
26892043-5	2016	We examined the role of PR-PPD in cell proliferation and signaling by stably expressing PR-B, or PR-B with disrupting mutations in the PPD (PR-BDeltaSH3), from a tetracycline-regulated promoter in A549 NSCLC cells.	tet	162-174	RB transcriptional corepressor 1	Homo sapiens	97-101
27126938-2	2016	METHODS: A human colorectal cancer cell line with tetracycline-inducible expression regulatory system, namely SW620/Tet-on, was established; inducible expression lentiviral vector with artificial microRNA targeting PAR4, pLVX-Tight-Puro-PAR4-miR, was constructed and transfected into SW620/Tet-on to make an inducible PAR4-suppressed cell model SW620/PAR4D.	tet	50-62	F2R like thrombin or trypsin receptor 3	Homo sapiens	237-241
27126938-2	2016	METHODS: A human colorectal cancer cell line with tetracycline-inducible expression regulatory system, namely SW620/Tet-on, was established; inducible expression lentiviral vector with artificial microRNA targeting PAR4, pLVX-Tight-Puro-PAR4-miR, was constructed and transfected into SW620/Tet-on to make an inducible PAR4-suppressed cell model SW620/PAR4D.	tet	50-62	membrane associated ring-CH-type finger 8	Homo sapiens	242-245
27126938-2	2016	METHODS: A human colorectal cancer cell line with tetracycline-inducible expression regulatory system, namely SW620/Tet-on, was established; inducible expression lentiviral vector with artificial microRNA targeting PAR4, pLVX-Tight-Puro-PAR4-miR, was constructed and transfected into SW620/Tet-on to make an inducible PAR4-suppressed cell model SW620/PAR4D.	tet	50-62	F2R like thrombin or trypsin receptor 3	Homo sapiens	237-241
26855221-8	2016	The thermodynamic study confirmed that TC adsorption onto TPC-ACs is a spontaneous process.	tet	39-41	solute carrier family 25 member 19	Homo sapiens	58-65
26234682-3	2016	RNA-sequencing-based transcriptome analysis revealed that tetracycline-mediated AREG silencing significantly altered the expression of 2331 genes, 623 of which were not normalized by treatment with EGF.	tet	58-70	amphiregulin	Homo sapiens	80-84
26880805-3	2016	We found that genetic ablation of Klf4 in pancreatic cancer cells isolated from Klf4(flox/flox) mice drastically increased CD44 expression and promoted the acquisition of stem-like properties, whereas tetracycline-inducible expression of KLF4 suppressed these properties in vitro and in vivo Further mechanistic investigation revealed that KLF4 bound to the CD44 promoter to negatively regulate transcription and also the expression of the CD44 variant.	tet	201-213	Kruppel-like factor 4 (gut)	Mus musculus	34-38
26880805-3	2016	We found that genetic ablation of Klf4 in pancreatic cancer cells isolated from Klf4(flox/flox) mice drastically increased CD44 expression and promoted the acquisition of stem-like properties, whereas tetracycline-inducible expression of KLF4 suppressed these properties in vitro and in vivo Further mechanistic investigation revealed that KLF4 bound to the CD44 promoter to negatively regulate transcription and also the expression of the CD44 variant.	tet	201-213	Kruppel-like factor 4 (gut)	Mus musculus	238-242
26673714-2	2016	To obtain versatile transgene system with combined benefits of a chemical inducer and light inducer, we created various chimeric promoters through the assembly of different copies of the tet operator and Gal4 operator module, which simultaneously responded to a tetracycline-responsive transcription factor and a light-switchable transactivator.	tet	262-274	galectin 4	Homo sapiens	204-208
27158672-1	2016	To elucidate the mechanisms for reverse LV remodeling, we generated a conditional (doxycycline [dox] off) transgenic mouse tetracycline transactivating factor-TRAF2 (tTA-TRAF2) that develops a dilated heart failure (HF) phenotype upon expression of a proinflammatory transgene, TNF receptor-associated factor 2 (TRAF2), and complete normalization of LV structure and function when the transgene is suppressed.	tet	123-135	TNF receptor-associated factor 2	Mus musculus	159-164
27158672-1	2016	To elucidate the mechanisms for reverse LV remodeling, we generated a conditional (doxycycline [dox] off) transgenic mouse tetracycline transactivating factor-TRAF2 (tTA-TRAF2) that develops a dilated heart failure (HF) phenotype upon expression of a proinflammatory transgene, TNF receptor-associated factor 2 (TRAF2), and complete normalization of LV structure and function when the transgene is suppressed.	tet	123-135	TNF receptor-associated factor 2	Mus musculus	170-175
27158672-1	2016	To elucidate the mechanisms for reverse LV remodeling, we generated a conditional (doxycycline [dox] off) transgenic mouse tetracycline transactivating factor-TRAF2 (tTA-TRAF2) that develops a dilated heart failure (HF) phenotype upon expression of a proinflammatory transgene, TNF receptor-associated factor 2 (TRAF2), and complete normalization of LV structure and function when the transgene is suppressed.	tet	123-135	TNF receptor-associated factor 2	Mus musculus	170-175
26777664-6	2016	This issue was investigated here using intrastriatal injections of a tetracycline-inducible adeno-associated viral vector expressing human GDNF cDNA (AAV-tetON-GDNF) in rats, and doxycycline (DOX; 0.01, 0.03, 0.5 and 3mg/ml) in the drinking water during 5weeks.	tet	69-81	glial cell derived neurotrophic factor	Homo sapiens	139-143
26915960-7	2016	Using a tetracycline-dependent inducible mouse model under the control of the forebrain-specific CaMKIIalpha promoter, we show here that the adult expression of Bcl11b is essential for survival, differentiation and functional integration of adult-born granule cell neurons.	tet	8-20	B cell leukemia/lymphoma 11B	Mus musculus	161-167
26777664-6	2016	This issue was investigated here using intrastriatal injections of a tetracycline-inducible adeno-associated viral vector expressing human GDNF cDNA (AAV-tetON-GDNF) in rats, and doxycycline (DOX; 0.01, 0.03, 0.5 and 3mg/ml) in the drinking water during 5weeks.	tet	69-81	glial cell derived neurotrophic factor	Homo sapiens	160-164
27006073-11	2016	An alternative, tetracycline-repressible pdgf-b system mediated expression of pdgf-b mRNA when maggots were raised on diet that lacked tetracycline.	tet	16-28	platelet derived growth factor subunit B	Homo sapiens	41-47
27013212-1	2016	In this issue of Blood, Schulze et al use a tetracycline-inducible Dnmt3b knock-in mouse model to investigate how DNMT3B-mediated DNA methylation affects leukemogenesis.	tet	44-56	DNA methyltransferase 3B	Mus musculus	67-73
27013212-1	2016	In this issue of Blood, Schulze et al use a tetracycline-inducible Dnmt3b knock-in mouse model to investigate how DNMT3B-mediated DNA methylation affects leukemogenesis.	tet	44-56	DNA methyltransferase 3B	Mus musculus	114-120
26729896-3	2016	To investigate how Dnmt3b-mediated DNA methylation affects leukemogenesis, we analyzed leukemia development under conditions of high and physiological methylation levels in a tetracycline-inducible knock-in mouse model.	tet	175-187	DNA methyltransferase 3B	Mus musculus	19-25
27006073-11	2016	An alternative, tetracycline-repressible pdgf-b system mediated expression of pdgf-b mRNA when maggots were raised on diet that lacked tetracycline.	tet	16-28	platelet derived growth factor subunit B	Homo sapiens	78-84
27006073-11	2016	An alternative, tetracycline-repressible pdgf-b system mediated expression of pdgf-b mRNA when maggots were raised on diet that lacked tetracycline.	tet	135-147	platelet derived growth factor subunit B	Homo sapiens	41-47
27006073-11	2016	An alternative, tetracycline-repressible pdgf-b system mediated expression of pdgf-b mRNA when maggots were raised on diet that lacked tetracycline.	tet	135-147	platelet derived growth factor subunit B	Homo sapiens	78-84
26773148-2	2016	Mice in which expression of CXCL1 is under the control of a tetracycline-inducible promoter active within glial fibrillary acidic protein-positive cells were generated and this allowed for selectively increasing CNS expression of CXCL1 in response to JHMV infection and evaluating the effects on neuroinflammation, control of viral replication, and demyelination.	tet	60-72	chemokine (C-X-C motif) ligand 1	Mus musculus	28-33
26929372-2	2016	In a transgenic model of breast cancer, Pten suppression using a tetracycline-regulatable short hairpin (sh)RNA cooperates with human epidermal growth factor receptor 2 (HER2/neu), leading to aggressive and metastatic disease with elevated signaling through PI3K and, surprisingly, the mitogen-activated protein kinase (MAPK) pathway.	tet	65-77	phosphatase and tensin homolog	Homo sapiens	40-44
26427661-0	2016	Synthetic Tet-inducible small hairpin RNAs targeting hTERT or Bcl-2 inhibit malignant phenotypes of bladder cancer T24 and 5637 cells.	tet	10-13	telomerase reverse transcriptase	Homo sapiens	53-58
26427661-0	2016	Synthetic Tet-inducible small hairpin RNAs targeting hTERT or Bcl-2 inhibit malignant phenotypes of bladder cancer T24 and 5637 cells.	tet	10-13	BCL2 apoptosis regulator	Homo sapiens	62-67
26887353-2	2016	By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics.	tet	130-133	zinc finger E-box binding homeobox 1	Homo sapiens	252-256
26887353-2	2016	By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics.	tet	130-133	zinc finger E-box binding homeobox 2	Homo sapiens	257-261
26887353-2	2016	By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics.	tet	130-133	epithelial splicing regulatory protein 1	Homo sapiens	263-268
26887353-2	2016	By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics.	tet	130-133	fibronectin 1	Homo sapiens	270-273
26887353-2	2016	By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics.	tet	130-133	formin homology 2 domain containing 1	Homo sapiens	277-282
26887353-2	2016	By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics.	tet	135-147	zinc finger E-box binding homeobox 1	Homo sapiens	252-256
26887353-2	2016	By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics.	tet	135-147	zinc finger E-box binding homeobox 2	Homo sapiens	257-261
26887353-2	2016	By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics.	tet	135-147	epithelial splicing regulatory protein 1	Homo sapiens	263-268
26887353-2	2016	By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics.	tet	135-147	fibronectin 1	Homo sapiens	270-273
26887353-2	2016	By developing a potent inhibitor of miR-200 family members (TuD-141/200c), the expression of which is strictly regulatable by the Tet (tetracycline)-On system, we found using a human colorectal cell line, HCT116, that several direct gene target mRNAs (Zeb1/Zeb2, ESRP1, FN1and FHOD1) of miR-200 family were elevated with distinct kinetics.	tet	135-147	formin homology 2 domain containing 1	Homo sapiens	277-282
26773148-2	2016	Mice in which expression of CXCL1 is under the control of a tetracycline-inducible promoter active within glial fibrillary acidic protein-positive cells were generated and this allowed for selectively increasing CNS expression of CXCL1 in response to JHMV infection and evaluating the effects on neuroinflammation, control of viral replication, and demyelination.	tet	60-72	chemokine (C-X-C motif) ligand 1	Mus musculus	230-235
26818323-8	2016	Quantitative analysis revealed that the beta-galactosidase activity within cells exposed to tetracycline increased 181-fold at 48 hours (p &lt; 0.001) and 47-fold at 72 hours after infection (p &lt; 0.05) compared with those without tetracycline.	tet	92-104	galactosidase beta 1	Homo sapiens	40-58
26763761-9	2016	Tetracycline hydrochloride has also protected bovine serum albumin (BSA) from radiation induced degradation.	tet	0-26	albumin	Homo sapiens	53-66
26756215-2	2016	Using a tetracycline-inducible transgenic mouse model that conditionally expresses activated IkappaB kinase beta (IKKbeta) in airway epithelium (IKTA), we found that sustained NF-kappaB signaling results in chronic inflammation and emphysema by 4 months.	tet	8-20	inhibitor of kappaB kinase beta	Mus musculus	93-112
26756215-2	2016	Using a tetracycline-inducible transgenic mouse model that conditionally expresses activated IkappaB kinase beta (IKKbeta) in airway epithelium (IKTA), we found that sustained NF-kappaB signaling results in chronic inflammation and emphysema by 4 months.	tet	8-20	inhibitor of kappaB kinase beta	Mus musculus	114-121
26802239-3	2016	To further explore the functional importance of specific AREG domains, we stably transduced keratinocytes expressing tetracycline-inducible AREG-targeted shRNA with lentiviruses expressing silencing-proof, membrane-tethered AREG cytoplasmic and extracellular domains (AREG-CTD and AREG-ECD), as well as full-length AREG precursor (proAREG).	tet	117-129	amphiregulin	Homo sapiens	140-144
26802239-3	2016	To further explore the functional importance of specific AREG domains, we stably transduced keratinocytes expressing tetracycline-inducible AREG-targeted shRNA with lentiviruses expressing silencing-proof, membrane-tethered AREG cytoplasmic and extracellular domains (AREG-CTD and AREG-ECD), as well as full-length AREG precursor (proAREG).	tet	117-129	amphiregulin	Homo sapiens	140-144
26802239-3	2016	To further explore the functional importance of specific AREG domains, we stably transduced keratinocytes expressing tetracycline-inducible AREG-targeted shRNA with lentiviruses expressing silencing-proof, membrane-tethered AREG cytoplasmic and extracellular domains (AREG-CTD and AREG-ECD), as well as full-length AREG precursor (proAREG).	tet	117-129	amphiregulin	Homo sapiens	140-144
26802239-3	2016	To further explore the functional importance of specific AREG domains, we stably transduced keratinocytes expressing tetracycline-inducible AREG-targeted shRNA with lentiviruses expressing silencing-proof, membrane-tethered AREG cytoplasmic and extracellular domains (AREG-CTD and AREG-ECD), as well as full-length AREG precursor (proAREG).	tet	117-129	amphiregulin	Homo sapiens	140-144
26802239-3	2016	To further explore the functional importance of specific AREG domains, we stably transduced keratinocytes expressing tetracycline-inducible AREG-targeted shRNA with lentiviruses expressing silencing-proof, membrane-tethered AREG cytoplasmic and extracellular domains (AREG-CTD and AREG-ECD), as well as full-length AREG precursor (proAREG).	tet	117-129	amphiregulin	Homo sapiens	140-144
26598443-7	2016	Tetracycline inducible re-expression of TFAP2B in IMR-32 and SH-EP neuroblastoma cells significantly impaired proliferation and cell cycle progression.	tet	0-12	transcription factor AP-2 beta	Homo sapiens	40-46
26353938-4	2016	We have analyzed resistance to beta-lactam antibiotics (BLr) and tetracycline (Tcr), screening for a variety of genes conferring each.	tet	65-77	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	79-82
26818323-8	2016	Quantitative analysis revealed that the beta-galactosidase activity within cells exposed to tetracycline increased 181-fold at 48 hours (p &lt; 0.001) and 47-fold at 72 hours after infection (p &lt; 0.05) compared with those without tetracycline.	tet	233-245	galactosidase beta 1	Homo sapiens	40-58
26538519-0	2015	How Epigallocatechin-3-gallate and Tetracycline Interact with the Josephin Domain of Ataxin-3 and Alter Its Aggregation Mode.	tet	35-47	ataxin 3	Homo sapiens	85-93
26640164-12	2016	The gene expressions of ER stress-related markers, including CHOP, GRP78, IRE-1alpha, and ATF6, which were downregulated by bicyclol pretreatment in tetracycline-injected mice.	tet	149-161	DNA-damage inducible transcript 3	Mus musculus	61-65
26640164-12	2016	The gene expressions of ER stress-related markers, including CHOP, GRP78, IRE-1alpha, and ATF6, which were downregulated by bicyclol pretreatment in tetracycline-injected mice.	tet	149-161	heat shock protein 5	Mus musculus	67-72
26640164-12	2016	The gene expressions of ER stress-related markers, including CHOP, GRP78, IRE-1alpha, and ATF6, which were downregulated by bicyclol pretreatment in tetracycline-injected mice.	tet	149-161	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	74-84
26640164-12	2016	The gene expressions of ER stress-related markers, including CHOP, GRP78, IRE-1alpha, and ATF6, which were downregulated by bicyclol pretreatment in tetracycline-injected mice.	tet	149-161	activating transcription factor 6	Mus musculus	90-94
27739375-7	2016	Our results showed that the T11 tetracycline-regulated promoter enabled improved transgene expression in a murine transplantation model.	tet	32-44	histocompatibility 2, T region locus 11, pseudogene	Mus musculus	28-31
27396594-0	2016	The Influence of Tetracycline Inducible Targeting Rat PPARgamma Gene Silencing on the Osteogenic and Adipogenic Differentiation of Bone Marrow Stromal Cells.	tet	17-29	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	54-63
27396594-3	2016	In this study, we construct rat PPARgamma gene shRNA Tet-on lentiviral vector, the lentiviral vector facilitated tetracycline (which has the characteristics of bone targeting)-inducible knockdown specific to PPARgamma gene, and transfect it into BMSCs, the silencing effects induced by tetracycline is significant.	tet	113-125	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	32-41
27396594-3	2016	In this study, we construct rat PPARgamma gene shRNA Tet-on lentiviral vector, the lentiviral vector facilitated tetracycline (which has the characteristics of bone targeting)-inducible knockdown specific to PPARgamma gene, and transfect it into BMSCs, the silencing effects induced by tetracycline is significant.	tet	113-125	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	208-217
27396594-3	2016	In this study, we construct rat PPARgamma gene shRNA Tet-on lentiviral vector, the lentiviral vector facilitated tetracycline (which has the characteristics of bone targeting)-inducible knockdown specific to PPARgamma gene, and transfect it into BMSCs, the silencing effects induced by tetracycline is significant.	tet	286-298	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	32-41
27396594-8	2016	These results suggest that the rat PPARgamma gene shRNA Teton lentiviral vector decreases adipogenic differentiation and promotes osteogenic differentiation in BMSCs induced by tetracycline.	tet	177-189	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	35-44
26928546-4	2016	To address this issue we generated a stable cell line with a tetracycline-inducible beta2AR tagged with a FLAG epitope, such that we are able to control the quantity of receptor produced.	tet	61-73	adrenoceptor beta 2	Homo sapiens	84-91
26164489-4	2015	In particular, significant fluorescence quenching was observed upon their binding with Tc in such complex biological milieu, which makes these Tc-MIP nanoparticles useful optical chemosensor with a detection limit of 0.26 muM.	tet	87-89	c-Maf inducing protein	Homo sapiens	143-149
26751691-5	2016	In the current study, we established Tet-On human corneal epithelial cell (hTCEpi) lines, which express tetracycline-inducible wild-type (wt) or catalytically-inactive (mu) ALDH3A1.	tet	104-116	aldehyde dehydrogenase 3 family member A1	Homo sapiens	173-180
25971915-4	2016	Delivering a tetracycline-inducible, myogenic differentiation 1 (MYOD1) piggyBac (PB) vector to human iPSCs enables the derivation of iPSCs that undergo uniform myogenic differentiation in a short period of time.	tet	13-25	myogenic differentiation 1	Homo sapiens	37-63
25971915-4	2016	Delivering a tetracycline-inducible, myogenic differentiation 1 (MYOD1) piggyBac (PB) vector to human iPSCs enables the derivation of iPSCs that undergo uniform myogenic differentiation in a short period of time.	tet	13-25	myogenic differentiation 1	Homo sapiens	65-70
26227038-4	2016	As an example, the cocrystallization of the tetracycline aptamer with U1A is also described.	tet	44-56	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	70-73
26709694-7	2015	MSCs-TetR/Amelx significantly overexpressed the Amelx gene and protein in the presence of the tetracycline derivative doxycycline.	tet	94-106	amelogenin, X-linked	Mus musculus	10-15
26709694-7	2015	MSCs-TetR/Amelx significantly overexpressed the Amelx gene and protein in the presence of the tetracycline derivative doxycycline.	tet	94-106	amelogenin, X-linked	Mus musculus	48-53
26709694-11	2015	These results suggest that a Tet-controlled Amelx gene regulation system for mouse MSCs was successfully established, in which transcriptional activation of Amelx was associated with enhanced osteogenic differentiation, especially in the early stage of biomineralization.	tet	29-32	amelogenin, X-linked	Mus musculus	44-49
26709694-11	2015	These results suggest that a Tet-controlled Amelx gene regulation system for mouse MSCs was successfully established, in which transcriptional activation of Amelx was associated with enhanced osteogenic differentiation, especially in the early stage of biomineralization.	tet	29-32	amelogenin, X-linked	Mus musculus	157-162
26674872-2	2015	To study the role of NRG2 in synaptogenesis at different developmental stages, newborn granule cells in rat hippocampal slice cultures were labeled with retrovirus encoding tetracycline-inducible microRNA targeting NRG2 and treated with doxycycline (Dox) at the fourth or seventh postinfection day (dpi).	tet	173-185	neuregulin 2	Rattus norvegicus	215-219
26536660-2	2015	In this study, and by means of the stable transfection of MCF-7 cells with ACSL4 using the tetracycline Tet-Off system (MCF-7 Tet-Off/ACSL4), we identify the mTOR pathway as one of the main specific signatures of ACSL4 expression and demonstrate the partial involvement of the lipoxygenase pathway in the activation of mTOR.	tet	91-103	acyl-CoA synthetase long chain family member 4	Homo sapiens	75-80
26536660-2	2015	In this study, and by means of the stable transfection of MCF-7 cells with ACSL4 using the tetracycline Tet-Off system (MCF-7 Tet-Off/ACSL4), we identify the mTOR pathway as one of the main specific signatures of ACSL4 expression and demonstrate the partial involvement of the lipoxygenase pathway in the activation of mTOR.	tet	91-103	acyl-CoA synthetase long chain family member 4	Homo sapiens	134-139
26536660-2	2015	In this study, and by means of the stable transfection of MCF-7 cells with ACSL4 using the tetracycline Tet-Off system (MCF-7 Tet-Off/ACSL4), we identify the mTOR pathway as one of the main specific signatures of ACSL4 expression and demonstrate the partial involvement of the lipoxygenase pathway in the activation of mTOR.	tet	91-103	mechanistic target of rapamycin kinase	Homo sapiens	158-162
26536660-2	2015	In this study, and by means of the stable transfection of MCF-7 cells with ACSL4 using the tetracycline Tet-Off system (MCF-7 Tet-Off/ACSL4), we identify the mTOR pathway as one of the main specific signatures of ACSL4 expression and demonstrate the partial involvement of the lipoxygenase pathway in the activation of mTOR.	tet	91-103	acyl-CoA synthetase long chain family member 4	Homo sapiens	134-139
26523458-0	2015	Adsorption between TC-stabilized AuNPs and the phosphate group: application of the PTP1B activity assay.	tet	19-21	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	83-88
26538519-3	2015	We previously showed that EGCG and tetracycline can contrast the aggregation process and toxicity of expanded AT3, although by different mechanisms.	tet	35-47	ataxin 3	Homo sapiens	110-113
26538519-5	2015	By protein solubility assays and FTIR spectroscopy we have first observed that EGCG and tetracycline affect the JD aggregation essentially in the same way displayed when acting on the full-length expanded AT3.	tet	88-100	ataxin 3	Homo sapiens	205-208
26538519-8	2015	Our investigations provide new details on the JD interaction with EGCG and tetracycline, which could explain the different mechanisms by which the two compounds reduce the toxicity of AT3.	tet	75-87	ataxin 3	Homo sapiens	184-187
26466815-5	2015	Briefly, SCs were transduced with a tetracycline-inducible (Tet-On) GDNF overexpressing lentivirus before transplantation.	tet	36-48	glial cell derived neurotrophic factor	Homo sapiens	68-72
26162528-6	2015	Further investigation on flocculation mechanism via pH monitoring, zeta potential measurements, floc properties analyses and spectral characterization indicated that, pairwise interactions among CND, copper(II) and TC were present in bridging flocculation, including charge attraction, coordination and hydrophobic effect.	tet	215-217	CND	Homo sapiens	195-198
26162528-7	2015	Based on these pairwise interactions, copper(II) and TC exerted "aid" roles to each other"s removal with the existence of CND, and preferable flocculation performance was thus achieved.	tet	53-55	CND	Homo sapiens	122-125
26453654-5	2015	Since Saccharomyces cerevisiae SEC15 is essential for viability, we generated a C. albicans conditional mutant strain in which SEC15 was placed under the control of a tetracycline-regulated promoter.	tet	167-179	Rab GTPase-binding exocyst subunit SEC15	Saccharomyces cerevisiae S288C	31-36
26453654-5	2015	Since Saccharomyces cerevisiae SEC15 is essential for viability, we generated a C. albicans conditional mutant strain in which SEC15 was placed under the control of a tetracycline-regulated promoter.	tet	167-179	Rab GTPase-binding exocyst subunit SEC15	Saccharomyces cerevisiae S288C	127-132
26452980-2	2015	Tetracycline-inducible Bcl-2/Bcl-xL dual knockdown markedly sensitized acute myeloid leukemia cells to the dual TORC1/2 inhibitor INK128 in vitro as well as in vivo.	tet	0-12	BCL2 apoptosis regulator	Homo sapiens	23-28
26452980-2	2015	Tetracycline-inducible Bcl-2/Bcl-xL dual knockdown markedly sensitized acute myeloid leukemia cells to the dual TORC1/2 inhibitor INK128 in vitro as well as in vivo.	tet	0-12	BCL2 like 1	Homo sapiens	29-35
26452980-2	2015	Tetracycline-inducible Bcl-2/Bcl-xL dual knockdown markedly sensitized acute myeloid leukemia cells to the dual TORC1/2 inhibitor INK128 in vitro as well as in vivo.	tet	0-12	CREB regulated transcription coactivator 1	Homo sapiens	112-119
26517688-0	2015	Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells.	tet	0-12	Pvt1 oncogene	Homo sapiens	59-63
26517688-4	2015	Furthermore we also used the emerging technology, synthetic biology, to create tetracycline-inducible small hairpin RNA (shRNA) vectors which silenced PVT1 in a dosage-dependent manner to inhibit the progression of bladder cancer.	tet	79-91	Pvt1 oncogene	Homo sapiens	151-155
26517688-6	2015	Synthetic "tetracycline-on" switch system can be used to quantitatively control the expression of PVT1 in bladder cancer in response to different concentration of doxycycline to suppress the progression of bladder cancer.	tet	11-23	Pvt1 oncogene	Homo sapiens	98-102
26335930-3	2015	Mice were engineered to overexpress Wnt1 in hepatocytes under the control of a tetracycline analogue.	tet	79-91	wingless-type MMTV integration site family, member 1	Mus musculus	36-40
26541358-0	2015	Synthetic Tet-inducible artificial microRNAs targeting beta-catenin or HIF-1alpha inhibit malignant phenotypes of bladder cancer cells T24 and 5637.	tet	10-13	catenin beta 1	Homo sapiens	55-67
26616387-3	2015	Here we report that human granulocyte macrophage-colony stimulating factor (GM-CSF) can sensitize the persister cells of Pseudomonas aeruginosa PAO1 and PDO300 to multiple antibiotics including ciprofloxacin, tobramycin, tetracycline, and gentamicin.	tet	221-233	colony stimulating factor 2	Homo sapiens	26-74
26616387-3	2015	Here we report that human granulocyte macrophage-colony stimulating factor (GM-CSF) can sensitize the persister cells of Pseudomonas aeruginosa PAO1 and PDO300 to multiple antibiotics including ciprofloxacin, tobramycin, tetracycline, and gentamicin.	tet	221-233	colony stimulating factor 2	Homo sapiens	76-82
26981373-4	2016	Furthermore, conditional expression of RelA using a Tetracycline-inducible system in Human Mammary Epithelial Cells (HRA cells) caused proliferation arrest while withdrawal of Doxycycline (Dox) and suppression of RelA expression in arrested cells restored cell cycle progression [1].	tet	52-64	RELA proto-oncogene, NF-kB subunit	Homo sapiens	39-43
26981373-4	2016	Furthermore, conditional expression of RelA using a Tetracycline-inducible system in Human Mammary Epithelial Cells (HRA cells) caused proliferation arrest while withdrawal of Doxycycline (Dox) and suppression of RelA expression in arrested cells restored cell cycle progression [1].	tet	52-64	RELA proto-oncogene, NF-kB subunit	Homo sapiens	213-217
26619124-2	2015	To better understand the molecular control of skin and hair color variation, we modulated the expression of Tyrosinase (Tyr), which controls the rate-limiting step of melanogenesis, by expressing a single-copy, tetracycline-inducible shRNA against Tyr in mice.	tet	211-223	tyrosinase	Mus musculus	108-118
26619124-2	2015	To better understand the molecular control of skin and hair color variation, we modulated the expression of Tyrosinase (Tyr), which controls the rate-limiting step of melanogenesis, by expressing a single-copy, tetracycline-inducible shRNA against Tyr in mice.	tet	211-223	tyrosinase	Mus musculus	108-111
26619124-2	2015	To better understand the molecular control of skin and hair color variation, we modulated the expression of Tyrosinase (Tyr), which controls the rate-limiting step of melanogenesis, by expressing a single-copy, tetracycline-inducible shRNA against Tyr in mice.	tet	211-223	tyrosinase	Mus musculus	120-123
26410455-4	2015	Additionally, thioredoxin (TRX2), a protein overexpressed exclusively under tetracycline"s influence, fused with the cyan fluorescent protein (CFP) to create a detector for this kind of chemical.	tet	76-88	thioredoxin TRX2	Saccharomyces cerevisiae S288C	27-31
26541358-0	2015	Synthetic Tet-inducible artificial microRNAs targeting beta-catenin or HIF-1alpha inhibit malignant phenotypes of bladder cancer cells T24 and 5637.	tet	10-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
26227349-4	2015	Cotransduction of AAV-tetracycline-controlled transactivator (tTA) and AAV-tet-response element (TRE)-CD74 resulted in CD74 expression, reduced Abeta production in mouse neurons containing the human APP with familial AD-linked mutations.	tet	22-34	CD74 molecule	Homo sapiens	119-123
26269457-5	2015	To examine the effect of endothelium-specific OGA overexpression on protein O-GlcNAcylation and coronary endothelial function in diabetic mice, we generated tetracycline-inducible, endothelium-specific OGA transgenic mice, and induced OGA by doxycycline administration in streptozotocin-induced type 1 diabetic mice.	tet	157-169	O-GlcNAcase	Mus musculus	46-49
26269457-5	2015	To examine the effect of endothelium-specific OGA overexpression on protein O-GlcNAcylation and coronary endothelial function in diabetic mice, we generated tetracycline-inducible, endothelium-specific OGA transgenic mice, and induced OGA by doxycycline administration in streptozotocin-induced type 1 diabetic mice.	tet	157-169	O-GlcNAcase	Mus musculus	202-205
26269457-5	2015	To examine the effect of endothelium-specific OGA overexpression on protein O-GlcNAcylation and coronary endothelial function in diabetic mice, we generated tetracycline-inducible, endothelium-specific OGA transgenic mice, and induced OGA by doxycycline administration in streptozotocin-induced type 1 diabetic mice.	tet	157-169	O-GlcNAcase	Mus musculus	202-205
26227349-4	2015	Cotransduction of AAV-tetracycline-controlled transactivator (tTA) and AAV-tet-response element (TRE)-CD74 resulted in CD74 expression, reduced Abeta production in mouse neurons containing the human APP with familial AD-linked mutations.	tet	22-34	amyloid beta (A4) precursor protein	Mus musculus	144-149
26430943-7	2015	OBJECTIVES: To assess susceptibility rates of GAS to penicillin, macrolides, clindamycin, and tetracycline in northern Israel and to compare the findings to the high antimicrobial susceptibility of GAS isolates reported in the same region in 2004 and to other geographical areas.	tet	94-106	gastrin	Homo sapiens	46-49
26430943-9	2015	RESULTS: In 300 samples, the susceptibility rates of GAS to penicillin, erythromycin, azithromycin, clindamycin, and tetracycline in northern Israel still remain very high.	tet	117-129	gastrin	Homo sapiens	53-56
26254831-0	2015	Tetracycline-regulated expression of OLIG2 gene in human dental pulp stem cells lead to mouse sciatic nerve regeneration upon transplantation.	tet	0-12	oligodendrocyte transcription factor 2	Homo sapiens	37-42
26169830-3	2015	To understand the function of Ctcfl, we created tetracycline-inducible Ctcfl transgenic mice.	tet	48-60	CCCTC-binding factor (zinc finger protein)-like	Mus musculus	30-35
26169830-3	2015	To understand the function of Ctcfl, we created tetracycline-inducible Ctcfl transgenic mice.	tet	48-60	CCCTC-binding factor (zinc finger protein)-like	Mus musculus	71-76
26284758-4	2015	We expressed SMAD4 in human PDAC cell lines BxPC3 and CFPAC1 by selection of stable clones containing an inducible SMAD4 tetracycline inducible expression system construct.	tet	121-133	SMAD family member 4	Homo sapiens	13-18
26284758-4	2015	We expressed SMAD4 in human PDAC cell lines BxPC3 and CFPAC1 by selection of stable clones containing an inducible SMAD4 tetracycline inducible expression system construct.	tet	121-133	SMAD family member 4	Homo sapiens	115-120
26254831-3	2015	In this study, a tetracycline (Tet)-inducible system expressing OLIG2 gene was transfected into human DPSCs to direct their differentiation toward oligodendrocyte progenitor cells (OPCs).	tet	17-29	oligodendrocyte transcription factor 2	Homo sapiens	64-69
26254831-3	2015	In this study, a tetracycline (Tet)-inducible system expressing OLIG2 gene was transfected into human DPSCs to direct their differentiation toward oligodendrocyte progenitor cells (OPCs).	tet	31-34	oligodendrocyte transcription factor 2	Homo sapiens	64-69
26254831-8	2015	Our findings showed that exogenous expression of the OLIG2 gene by a Tet-regulated system could be used as an efficient way to induce the differentiation of DPSCs into functional oligodendrocytes.	tet	69-72	oligodendrocyte transcription factor 2	Homo sapiens	53-58
26427054-4	2015	Overexpressing COX20 using a tetracycline-regulatable expression vector system in a Deltacox20 strain, resulted in tolerance to the presence of acetic acid and tolerance could be ablated with addition of tetracycline.	tet	29-41	Cox20p	Saccharomyces cerevisiae S288C	15-20
26427054-4	2015	Overexpressing COX20 using a tetracycline-regulatable expression vector system in a Deltacox20 strain, resulted in tolerance to the presence of acetic acid and tolerance could be ablated with addition of tetracycline.	tet	204-216	Cox20p	Saccharomyces cerevisiae S288C	15-20
26382615-3	2015	Here, we developed an embryonic stem (ES) cell-based model in which Tbx1 expression can be modulated by tetracycline.	tet	104-116	T-box transcription factor 1	Homo sapiens	68-72
26003047-5	2015	For the current study, we used transgenic mice with a tetracycline-regulated transcriptional transactivator linked to the bovine keratin 5 promoter (K5tTA) to drive expression of LGR5 in the epidermis.	tet	54-66	leucine rich repeat containing G protein-coupled receptor 5	Bos taurus	179-183
26113075-4	2015	To demonstrate its functionality, we constitutively expressed the well-described transcription factor Meis1 followed by inducible co-expression of collaborating partner Hoxa9 under the control of tetracycline responsive promoters in murine fibroblasts and primary hematopoietic progenitor cells (HPCs).	tet	196-208	homeobox A9	Mus musculus	169-174
26004127-1	2015	Doxycycline, a tetracycline-based antibiotic, has been reported to attenuate melanoma cell migration through inhibiting the focal adhesion kinase (FAK) signaling pathway.	tet	15-27	protein tyrosine kinase 2	Homo sapiens	124-145
26004127-1	2015	Doxycycline, a tetracycline-based antibiotic, has been reported to attenuate melanoma cell migration through inhibiting the focal adhesion kinase (FAK) signaling pathway.	tet	15-27	protein tyrosine kinase 2	Homo sapiens	147-150
25820021-4	2015	In tetracycline-inducible OAT4-expressing cells, [(3) H]olmesartan uptake was increased by tetracycline treatment.	tet	3-15	solute carrier family 22 member 11	Homo sapiens	26-30
25820021-4	2015	In tetracycline-inducible OAT4-expressing cells, [(3) H]olmesartan uptake was increased by tetracycline treatment.	tet	91-103	solute carrier family 22 member 11	Homo sapiens	26-30
26008138-5	2015	Moreover, MMPs are chemically inhibited by tetracycline-group antibiotics, such as doxycycline.	tet	43-55	matrix metallopeptidase 8	Homo sapiens	10-14
26081484-8	2015	This is the case for dpb11-iAID and mcm10-iAID cells after the addition of tetracycline and auxin.	tet	75-87	protein kinase activating protein DPB11	Saccharomyces cerevisiae S288C	21-26
26101157-4	2015	We found that using doxycycline to control Pgp expression has a significant advantage over tetracycline, in that doxycycline caused less endogenous gene expression modification/perturbation, and was more potent than tetracycline in suppressing Pgp expression.	tet	216-228	ATP binding cassette subfamily B member 1	Homo sapiens	43-46
26101157-4	2015	We found that using doxycycline to control Pgp expression has a significant advantage over tetracycline, in that doxycycline caused less endogenous gene expression modification/perturbation, and was more potent than tetracycline in suppressing Pgp expression.	tet	216-228	ATP binding cassette subfamily B member 1	Homo sapiens	244-247
25862466-5	2015	When 5 mug/ml hBD3-CBD was combined with antibiotics, it decreased the MIC50 and MIC90 of tetracycline, rifampicin, and streptomycin against clinical P. aeruginosa isolates.	tet	90-102	defensin beta 103B	Homo sapiens	14-18
26053132-7	2015	Tetracycline was released faster from the mesh at higher blend ratios of EPO for both pH values.	tet	0-12	erythropoietin	Homo sapiens	73-76
26053132-8	2015	The electrostatic interaction between EPO and L100 is expected to yield different release profiles of tetracycline.	tet	102-114	erythropoietin	Homo sapiens	38-41
25288151-9	2015	Thus, an inducible CRT stNB-V1 cell line was generated by a tetracycline-regulated gene system.	tet	60-72	calreticulin	Homo sapiens	19-22
25288151-9	2015	Thus, an inducible CRT stNB-V1 cell line was generated by a tetracycline-regulated gene system.	tet	60-72	stonin 2	Homo sapiens	23-27
26081484-8	2015	This is the case for dpb11-iAID and mcm10-iAID cells after the addition of tetracycline and auxin.	tet	75-87	Mcm10p	Saccharomyces cerevisiae S288C	36-41
25885930-2	2015	Here we generated the Ins1-Cre-Dsred and Ins1-rtTA mouse models, which expressed the Cre recombinase or reverse tetracycline regulatable transactivator (rtTA) without hGH minigene under the control of mouse Ins1 promoter.	tet	112-124	insulin I	Mus musculus	22-26
26018079-4	2015	In the present study, we first established a HEK293 cell line, which stably expresses a fluorescent peroxisome marker protein (DsRed2-Peroxi) and expresses PLA/AT-3 in a tetracycline-dependent manner.	tet	170-182	ataxin 3	Homo sapiens	160-164
26018079-5	2015	The treatment with tetracycline, as expected, caused disappearance of peroxisomes within 24 h, as revealed by diffuse signals of DsRed2-Peroxi and a remarkable decrease in a peroxisomal membrane protein, PMP70.	tet	19-31	ATP binding cassette subfamily D member 3	Homo sapiens	204-209
25693514-5	2015	To investigate the role of Id3 in malignant squamous cell carcinoma (SCC) cells (A431), a tetracycline-regulated inducible system was used to induce Id3 in cell culture and mouse xenograft models.	tet	90-102	inhibitor of DNA binding 3	Mus musculus	149-152
26091426-3	2015	A paper presented within describes the development and characterization of 2 new transgenic mice expressing Cre recombinase under the mouse insulin1 promoter that are useful for beta-cell-specific gene ablation: the first is constitutive and coexpresses DsRed (Ins1-Cre-DsRed); the second allows beta-cell-specific expression of the reverse tetracycline-controlled transactivator, which can be used for drug-dependent expression of a target gene of interest for overexpression studies.	tet	341-353	insulin I	Mus musculus	140-148
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	21-33	interferon alpha-A	Bos taurus	47-56
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	21-33	erythropoietin	Bos taurus	57-60
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	21-33	interferon alpha-A	Bos taurus	210-219
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	21-33	erythropoietin	Bos taurus	220-223
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	21-24	interferon alpha-A	Bos taurus	47-56
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	21-24	erythropoietin	Bos taurus	57-60
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	21-24	interferon alpha-A	Bos taurus	210-219
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	21-24	erythropoietin	Bos taurus	220-223
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	35-38	interferon alpha-A	Bos taurus	47-56
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	35-38	erythropoietin	Bos taurus	57-60
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	35-38	interferon alpha-A	Bos taurus	210-219
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	35-38	erythropoietin	Bos taurus	220-223
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	248-260	interferon alpha-A	Bos taurus	47-56
25779628-7	2015	Therefore, a unitary tetracycline (tet)-on the IFN-alpha/EPO vector was established, which combined a tet-on activator cassette controlled by the alphaS1-casein promoter, with a responder cassette encoding the IFN-alpha/EPO gene, controlled by the tetracycline response element (TRE) promoter.	tet	248-260	erythropoietin	Bos taurus	57-60
25779628-8	2015	In these systems, the tet-controlled transactivator is affected by mammary gland-specific alphaS1-casein promoter, and binding of the transcriptional activator to the TRE results in transcription of the downstream IFN-alpha/EPO genes in the presence of dox.	tet	22-25	interferon alpha-A	Bos taurus	214-223
25779628-8	2015	In these systems, the tet-controlled transactivator is affected by mammary gland-specific alphaS1-casein promoter, and binding of the transcriptional activator to the TRE results in transcription of the downstream IFN-alpha/EPO genes in the presence of dox.	tet	22-25	erythropoietin	Bos taurus	224-227
25779628-9	2015	To assess this, the unitary tet-on IFN-alpha/EPO vector was introduced into a bovine mammary gland cell line (MAC-T), and the cells were then treated with 0.1-1 microg/ml dox.	tet	28-31	interferon alpha-A	Bos taurus	35-44
25779628-9	2015	To assess this, the unitary tet-on IFN-alpha/EPO vector was introduced into a bovine mammary gland cell line (MAC-T), and the cells were then treated with 0.1-1 microg/ml dox.	tet	28-31	erythropoietin	Bos taurus	45-48
26062605-3	2015	RESULTS: RCK2 encodes for a MAPKAP (MAPK-activated protein kinase) enzyme and was identified on a locus by QTL analysis in yeast cells under osmotic stress, RCK2 expression was placed under a tetracycline regulatable vector and rescued glucose, sorbitol or glycerol induced osmotic stress in an rck2 null strain.	tet	192-204	serine/threonine protein kinase RCK2	Saccharomyces cerevisiae S288C	9-13
26062605-3	2015	RESULTS: RCK2 encodes for a MAPKAP (MAPK-activated protein kinase) enzyme and was identified on a locus by QTL analysis in yeast cells under osmotic stress, RCK2 expression was placed under a tetracycline regulatable vector and rescued glucose, sorbitol or glycerol induced osmotic stress in an rck2 null strain.	tet	192-204	serine/threonine protein kinase RCK2	Saccharomyces cerevisiae S288C	157-161
26062605-3	2015	RESULTS: RCK2 encodes for a MAPKAP (MAPK-activated protein kinase) enzyme and was identified on a locus by QTL analysis in yeast cells under osmotic stress, RCK2 expression was placed under a tetracycline regulatable vector and rescued glucose, sorbitol or glycerol induced osmotic stress in an rck2 null strain.	tet	192-204	serine/threonine protein kinase RCK2	Saccharomyces cerevisiae S288C	295-299
26062605-6	2015	Tolerance to osmotic stress using the tetracycline regulatable vectors could be turned off with the addition of tetracycline returning a rck2 null strain back to osmotic sensitivity.	tet	38-50	serine/threonine protein kinase RCK2	Saccharomyces cerevisiae S288C	137-141
26062605-6	2015	Tolerance to osmotic stress using the tetracycline regulatable vectors could be turned off with the addition of tetracycline returning a rck2 null strain back to osmotic sensitivity.	tet	112-124	serine/threonine protein kinase RCK2	Saccharomyces cerevisiae S288C	137-141
25745068-8	2015	Tetracycline downregulated extracellular signal-regulated kinase (ERK) phosphorylation, which negatively regulated DGAT2 expression.	tet	0-12	mitogen-activated protein kinase 1	Mus musculus	27-64
26323451-0	2015	Alpha-2-Macroglobulin Levels in Gingival Crevicular Fluid Pre- and Post-scaling and Root Planing with Adjunctive Tetracycline Fibers in Chronic Periodontitis: A Randomized Controlled Trial.	tet	113-125	alpha-2-macroglobulin	Homo sapiens	0-21
26323451-1	2015	BACKGROUND: This split-mouth clinical study aimed to investigate levels of alpha-2-macroglobulin (a2M) in gingival crevicular fluid (GCF) of chronic periodontitis patients pre- and post-scaling and root planing (SRP) with or without adjunctive use of tetracycline fibers.	tet	251-263	alpha-2-macroglobulin	Homo sapiens	75-96
25690653-3	2015	Here, we show that lncRNAs are a main component of the Myc-regulated transcriptional program using the P493-6 tetracycline-repressible myc model.	tet	110-122	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	55-58
25690653-3	2015	Here, we show that lncRNAs are a main component of the Myc-regulated transcriptional program using the P493-6 tetracycline-repressible myc model.	tet	110-122	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	135-138
25745068-8	2015	Tetracycline downregulated extracellular signal-regulated kinase (ERK) phosphorylation, which negatively regulated DGAT2 expression.	tet	0-12	mitogen-activated protein kinase 1	Mus musculus	66-69
25745068-8	2015	Tetracycline downregulated extracellular signal-regulated kinase (ERK) phosphorylation, which negatively regulated DGAT2 expression.	tet	0-12	diacylglycerol O-acyltransferase 2	Mus musculus	115-120
25745068-10	2015	DGAT1 and 2 knock-down with specific small interfering (si)-RNA completely abrogated the steatogenic effect of tetracycline in HepG2 cells.	tet	111-123	diacylglycerol O-acyltransferase 1	Homo sapiens	0-11
25745068-11	2015	Taken together, our data showed that tetracycline induces lipid accumulation by facilitating fatty acid transport and triglyceride esterification by upregulating CD36 and DGAT2, respectively.	tet	37-49	diacylglycerol O-acyltransferase 2	Mus musculus	171-176
25576488-4	2015	SHP was found to be repressed by steatotic drugs (valproate, doxycycline, tetracycline, and cyclosporin A) in cultured hepatic cells and the livers of different animal models of NAFLD: iatrogenic (tetracycline-treated rats), genetic (glycine N-methyltransferase-deficient mice), and nutritional (mice fed a methionine- and choline-deficient diet).	tet	74-86	nuclear receptor subfamily 0, group B, member 2	Rattus norvegicus	0-3
26025395-0	2015	Conditional control of dendritic cell factor 1 expression by a tetracycline-inducible system.	tet	63-75	transmembrane protein 59	Homo sapiens	23-46
26025395-2	2015	Here, we used a tetracycline&amp;mdash;inducible system that regulates the expression of Dendritic cell factor 1 in glioma cells.	tet	16-28	transmembrane protein 59	Homo sapiens	89-112
25946042-3	2015	The rTg9191 mice harbor a transgene encoding the 695 amino-acid isoform of human amyloid precursor protein (APP) with the Swedish and London mutations (APPNLI) linked to familial Alzheimer"s disease, under the control of a tetracycline-response element, as well as a transgene encoding the tetracycline transactivator, under the control of the promoter for calcium-calmodulin kinase IIalpha.	tet	223-235	amyloid beta precursor protein	Homo sapiens	81-106
25972844-9	2015	When screened for five different antibiotic resistance genes conferring macrolide, tetracycline, and beta-lactam resistance, clinical E. coli isolates were more likely to harbor ermB and bla OXA than isolates from urban waterway.	tet	83-95	beta-lactamase	Escherichia coli	187-190
25140386-0	2015	Targeting of plasminogen activator inhibitor 1 improves fibrinolytic therapy for tetracycline-induced pleural injury in rabbits.	tet	81-93	plasminogen activator inhibitor 1	Oryctolagus cuniculus	13-46
25601273-5	2015	Rescue of Zap70 expression in Zap70(-/-) mice using a tetracycline-inducible Zap70 transgene, that is not subject to positive feedback by TCR signalling, restored positive selection of Class-II-restricted thymocytes.	tet	54-66	zeta-chain (TCR) associated protein kinase	Mus musculus	10-15
25601273-5	2015	Rescue of Zap70 expression in Zap70(-/-) mice using a tetracycline-inducible Zap70 transgene, that is not subject to positive feedback by TCR signalling, restored positive selection of Class-II-restricted thymocytes.	tet	54-66	zeta-chain (TCR) associated protein kinase	Mus musculus	30-35
25601273-5	2015	Rescue of Zap70 expression in Zap70(-/-) mice using a tetracycline-inducible Zap70 transgene, that is not subject to positive feedback by TCR signalling, restored positive selection of Class-II-restricted thymocytes.	tet	54-66	zeta-chain (TCR) associated protein kinase	Mus musculus	30-35
25980494-2	2015	Here we analyzed c-Src contribution to initial steps of metastasis by tetracycline-dependent expression of a specific shRNA-c-Src, which suppressed c-Src mRNA and protein levels in metastatic MDA-MB-231 cells.	tet	70-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	17-22
25980494-2	2015	Here we analyzed c-Src contribution to initial steps of metastasis by tetracycline-dependent expression of a specific shRNA-c-Src, which suppressed c-Src mRNA and protein levels in metastatic MDA-MB-231 cells.	tet	70-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	124-129
25980494-2	2015	Here we analyzed c-Src contribution to initial steps of metastasis by tetracycline-dependent expression of a specific shRNA-c-Src, which suppressed c-Src mRNA and protein levels in metastatic MDA-MB-231 cells.	tet	70-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	124-129
24931169-6	2015	When expressed in a tetracycline-inducible manner, the ectopically expressed activated form of Notch1 (ICN1) displayed oncogene-like characteristics inducing cellular senescence corroborated by the induction of G0/G1 cell-cycle arrest, Rb dephosphorylation, flat and enlarged cell morphology and senescence-associated beta-galactosidase activity.	tet	20-32	notch receptor 1	Homo sapiens	95-101
24931169-6	2015	When expressed in a tetracycline-inducible manner, the ectopically expressed activated form of Notch1 (ICN1) displayed oncogene-like characteristics inducing cellular senescence corroborated by the induction of G0/G1 cell-cycle arrest, Rb dephosphorylation, flat and enlarged cell morphology and senescence-associated beta-galactosidase activity.	tet	20-32	galactosidase beta 1	Homo sapiens	318-336
25780421-4	2015	In this study, tetracycline-inducible lentivirus-mediated RNA interference (RNAi) was employed to knock down microtubule-associated protein 1 light chain 3 (LC3) gene, which encodes a key protein in the induction of autophagy, to study the protective function of autophagy in liver cancer tolerant to epirubicin.	tet	15-27	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	157-160
25573953-7	2015	Tumor xenograft formation was severely inhibited by DHHC5 knockdown and rescued by DHHC5 expression, using both a conventional and tetracycline-inducible shRNA.	tet	131-143	zinc finger DHHC-type palmitoyltransferase 5	Homo sapiens	83-88
25576488-4	2015	SHP was found to be repressed by steatotic drugs (valproate, doxycycline, tetracycline, and cyclosporin A) in cultured hepatic cells and the livers of different animal models of NAFLD: iatrogenic (tetracycline-treated rats), genetic (glycine N-methyltransferase-deficient mice), and nutritional (mice fed a methionine- and choline-deficient diet).	tet	197-209	nuclear receptor subfamily 0, group B, member 2	Rattus norvegicus	0-3
25702640-4	2015	The system, termed pB-Tet-GOI (piggyBac-transposable tetracycline transactivator-mediated flexible expression of a genetic element of interest), incorporates the latest generation of tetracycline (Tet) transactivator and reverse Tet transactivator variants--along with engineered mutants--in order to provide regulated transgene expression upon addition or removal of doxycycline (dox).	tet	53-65	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	19-29
25721668-4	2015	Using tetracycline inducible-hCAR system in HepG2 cells, we showed that knockdown of PRMT5 with small interfering RNA suppressed tetracycline -induced mRNA expression of CYP2B6 but not of CYP2C9 or CYP3A4.	tet	6-18	CXADR Ig-like cell adhesion molecule	Homo sapiens	29-33
25721668-4	2015	Using tetracycline inducible-hCAR system in HepG2 cells, we showed that knockdown of PRMT5 with small interfering RNA suppressed tetracycline -induced mRNA expression of CYP2B6 but not of CYP2C9 or CYP3A4.	tet	6-18	protein arginine methyltransferase 5	Homo sapiens	85-90
25721668-4	2015	Using tetracycline inducible-hCAR system in HepG2 cells, we showed that knockdown of PRMT5 with small interfering RNA suppressed tetracycline -induced mRNA expression of CYP2B6 but not of CYP2C9 or CYP3A4.	tet	6-18	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	170-176
25721668-4	2015	Using tetracycline inducible-hCAR system in HepG2 cells, we showed that knockdown of PRMT5 with small interfering RNA suppressed tetracycline -induced mRNA expression of CYP2B6 but not of CYP2C9 or CYP3A4.	tet	129-141	CXADR Ig-like cell adhesion molecule	Homo sapiens	29-33
25721668-4	2015	Using tetracycline inducible-hCAR system in HepG2 cells, we showed that knockdown of PRMT5 with small interfering RNA suppressed tetracycline -induced mRNA expression of CYP2B6 but not of CYP2C9 or CYP3A4.	tet	129-141	protein arginine methyltransferase 5	Homo sapiens	85-90
25721668-4	2015	Using tetracycline inducible-hCAR system in HepG2 cells, we showed that knockdown of PRMT5 with small interfering RNA suppressed tetracycline -induced mRNA expression of CYP2B6 but not of CYP2C9 or CYP3A4.	tet	129-141	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	170-176
25823013-3	2015	Herein, we describe a system based upon a bidirectional Herpes simplex virus type 1 promoter that is naturally responsive to the VP16 transactivator and modified to permit tetracycline-regulated transcription on one side while maintaining constitutive activity on the other side.	tet	172-184	host cell factor C1	Homo sapiens	129-133
25755634-5	2015	To overcome these limitations, we developed a tetracycline-inducible TetO-CB-myc6-Rb1 (CBRb) mouse model to achieve transient and inducible dominant-negative (DN) inhibition of the endogenous RB1 protein.	tet	46-58	RB transcriptional corepressor 1	Mus musculus	82-85
25741594-2	2015	Using a tetracycline-inducible system, we report here that an increased expression of TIA1 or TIAR in 293 cells results in reduced rates of cell proliferation.	tet	8-20	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	86-90
25741594-2	2015	Using a tetracycline-inducible system, we report here that an increased expression of TIA1 or TIAR in 293 cells results in reduced rates of cell proliferation.	tet	8-20	TIA1 cytotoxic granule associated RNA binding protein like 1	Homo sapiens	94-98
25398493-6	2015	The second-generation tetracycline-responsive promoter (P tight) was used in order to provide low basal expression in the absence of Dox and high-level Dox-induced expression of TrkC.	tet	22-34	neurotrophic receptor tyrosine kinase 3	Rattus norvegicus	178-182
25755634-5	2015	To overcome these limitations, we developed a tetracycline-inducible TetO-CB-myc6-Rb1 (CBRb) mouse model to achieve transient and inducible dominant-negative (DN) inhibition of the endogenous RB1 protein.	tet	46-58	RB transcriptional corepressor 1	Mus musculus	192-195
25471153-3	2015	The genetic interaction was also confirmed by repression of MNN2, which encodes alpha-1,2-mannosyltransferase that synthesizes mannan-type N-glycans, by a tetracycline-regulatable system.	tet	155-167	alpha-1,2-mannosyltransferase MNN2	Saccharomyces cerevisiae S288C	60-64
25605940-5	2015	MITF expression in the tetracycline-inducible C32 melanoma model caused a marked increase in vesicular structures, and increased expression of late endosomal proteins, such as Rab7, LAMP1, and CD63.	tet	23-35	melanocyte inducing transcription factor	Homo sapiens	0-4
25605940-5	2015	MITF expression in the tetracycline-inducible C32 melanoma model caused a marked increase in vesicular structures, and increased expression of late endosomal proteins, such as Rab7, LAMP1, and CD63.	tet	23-35	lysosomal associated membrane protein 1	Homo sapiens	182-187
25605940-5	2015	MITF expression in the tetracycline-inducible C32 melanoma model caused a marked increase in vesicular structures, and increased expression of late endosomal proteins, such as Rab7, LAMP1, and CD63.	tet	23-35	CD63 molecule	Homo sapiens	193-197
25444916-8	2015	Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells.	tet	32-44	tumor protein p53	Homo sapiens	25-28
25444916-8	2015	Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells.	tet	32-44	microRNA 192	Homo sapiens	114-121
25444916-8	2015	Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells.	tet	32-44	tumor protein p53	Homo sapiens	149-152
25395405-6	2015	Tetracycline (tet)-induced overexpression of Mgat1, Mgat5 and Mgat6 resulted in increased enzyme activity and increased N-glycan branching concordant with the known specificities of these enzymes.	tet	0-12	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	45-50
25395405-6	2015	Tetracycline (tet)-induced overexpression of Mgat1, Mgat5 and Mgat6 resulted in increased enzyme activity and increased N-glycan branching concordant with the known specificities of these enzymes.	tet	0-12	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	52-57
25395405-6	2015	Tetracycline (tet)-induced overexpression of Mgat1, Mgat5 and Mgat6 resulted in increased enzyme activity and increased N-glycan branching concordant with the known specificities of these enzymes.	tet	14-17	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	45-50
25395405-6	2015	Tetracycline (tet)-induced overexpression of Mgat1, Mgat5 and Mgat6 resulted in increased enzyme activity and increased N-glycan branching concordant with the known specificities of these enzymes.	tet	14-17	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	52-57
25395405-9	2015	In low glutamine and Glc medium, tet-induced Mgat5 alone increased amino acids uptake, intracellular levels of glycolytic and TCA intermediates, as well as HEK293 cell growth.	tet	33-36	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	45-50
25395405-10	2015	More specifically, tet-induced Mgat5 and HBP elevated the import rate of glutamine, although transport of other metabolites may be regulated in parallel.	tet	19-22	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	31-36
25675217-1	2015	In enteroaggregative hemorrhagic Escherichia coli (EAHEC) O104 the complex antibiotic resistance gene loci (CRL) found in the region of divergence 1 (RD1) within E. coli genomic island 3 (GI3) contains blaTEM-1, strAB, sul2, tet(A)A, and dfrA7 genes encoding resistance to ampicillin, streptomycin, sulfamethoxazole, tetracycline and trimethoprim respectively.	tet	317-329	dihydropteroate synthase protein Sul2	Escherichia coli	219-223
25675217-1	2015	In enteroaggregative hemorrhagic Escherichia coli (EAHEC) O104 the complex antibiotic resistance gene loci (CRL) found in the region of divergence 1 (RD1) within E. coli genomic island 3 (GI3) contains blaTEM-1, strAB, sul2, tet(A)A, and dfrA7 genes encoding resistance to ampicillin, streptomycin, sulfamethoxazole, tetracycline and trimethoprim respectively.	tet	317-329	DfrA7	Escherichia coli	238-243
25662235-2	2015	In this work, a novel adsorbent, Fe3O4 incorporated polyacrylonitrile nanofiber mat (Fe-NFM), was successfully fabricated via electrospinning and solvothermal method, targeting to remove tetracycline (TC), a typical class of antibiotics, from aqueous solution.	tet	187-199	neurofilament medium chain	Homo sapiens	88-91
25662235-2	2015	In this work, a novel adsorbent, Fe3O4 incorporated polyacrylonitrile nanofiber mat (Fe-NFM), was successfully fabricated via electrospinning and solvothermal method, targeting to remove tetracycline (TC), a typical class of antibiotics, from aqueous solution.	tet	201-203	neurofilament medium chain	Homo sapiens	88-91
25662235-4	2015	A series of adsorption experiments were carried out to evaluate the removal efficiency of TC by the Fe-NFM.	tet	90-92	neurofilament medium chain	Homo sapiens	103-106
25662235-7	2015	The adsorption of TC on Fe-NFM was a combination effect of both electrostatic interaction and complexation between TC and Fe-NFM.	tet	18-20	neurofilament medium chain	Homo sapiens	27-30
25662235-7	2015	The adsorption of TC on Fe-NFM was a combination effect of both electrostatic interaction and complexation between TC and Fe-NFM.	tet	18-20	neurofilament medium chain	Homo sapiens	125-128
25662235-7	2015	The adsorption of TC on Fe-NFM was a combination effect of both electrostatic interaction and complexation between TC and Fe-NFM.	tet	115-117	neurofilament medium chain	Homo sapiens	27-30
25291963-12	2014	Likewise, runt-related transcription factor 2 and collagen type I alpha1 were low at TC concentration of 0.5 mg/mL.	tet	85-87	RUNX family transcription factor 2	Homo sapiens	10-45
26370682-5	2015	The present study revealed that simultaneous induction of Bmal1 and Clock had an influential effect on the cell cycle in SW480/T-REx/Clock/Bmal1 cells, in which both Clock and Bmal1 could be induced by tetracycline.	tet	202-214	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	58-63
26370682-5	2015	The present study revealed that simultaneous induction of Bmal1 and Clock had an influential effect on the cell cycle in SW480/T-REx/Clock/Bmal1 cells, in which both Clock and Bmal1 could be induced by tetracycline.	tet	202-214	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	139-144
26370682-5	2015	The present study revealed that simultaneous induction of Bmal1 and Clock had an influential effect on the cell cycle in SW480/T-REx/Clock/Bmal1 cells, in which both Clock and Bmal1 could be induced by tetracycline.	tet	202-214	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	139-144
26374153-5	2015	Cells with tetracycline-induced expression of the p63 isoforms were compared to control cells with wildtype expression.	tet	11-23	tumor protein p63	Homo sapiens	50-53
25331947-4	2014	LCMS proteomic analysis of LAP-TAP-purified proteins from HeLa cells containing a tetracycline-inducible GFP-S peptide-NFkappaB expression system identified gigaxonin, an ubiquitin E3 ligase adaptor, as an NFkappaB-interacting protein.	tet	82-94	nuclear factor kappa B subunit 1	Homo sapiens	119-127
25331947-4	2014	LCMS proteomic analysis of LAP-TAP-purified proteins from HeLa cells containing a tetracycline-inducible GFP-S peptide-NFkappaB expression system identified gigaxonin, an ubiquitin E3 ligase adaptor, as an NFkappaB-interacting protein.	tet	82-94	nuclear factor kappa B subunit 1	Homo sapiens	206-214
24125013-6	2014	The results help to understand the differences in the binding modes of related compounds and, therefore, add to further design of novel tetracycline-based inhibitors for MMP enzymes.	tet	136-148	matrix metallopeptidase 2	Homo sapiens	170-173
25231298-5	2014	By using tetracycline-inducible HBV-producing cells, we observed that lentivirus-mediated DDX3 expression led to a reduced level of HBV RNAs.	tet	9-21	DEAD-box helicase 3 X-linked	Homo sapiens	90-94
25231298-6	2014	Importantly, knockdown of DDX3 by short hairpin RNA resulted in augmentation of HBV RNAs in two distinct HBV replication systems: (i) tetracycline-inducible HBV-producing cells and (ii) constitutive HBV-producing HepG2.2.15 cells.	tet	134-146	DEAD-box helicase 3 X-linked	Homo sapiens	26-30
25395622-4	2015	Overexpression of the single-chain SPT fusion protein under the control of a tetracycline-inducible promoter in stably transfected cells resulted in increased endogenous ORMDL expression.	tet	77-89	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	35-38
26556957-3	2015	In order to concoct a viable prolonged treatment for bone cancer pain, an inducible lentivirus LvOn-siTLR4 (tetracycline inducible lentivirus carrying siRNA targeting TLR4) was prepared and the antinociception effects were observed in bone cancer pain rats induced by Walker 256 cells injection in left leg.	tet	108-120	toll-like receptor 4	Rattus norvegicus	102-106
25535864-3	2015	To examine the function of this signaling pathway in the intact nervous system, we developed a transgenic mouse model in which noggin expression can be induced specifically in NSC via a nestin-driven reverse tetracycline-controlled transactivator (rtTA).	tet	208-220	noggin	Mus musculus	127-133
25291963-12	2014	Likewise, runt-related transcription factor 2 and collagen type I alpha1 were low at TC concentration of 0.5 mg/mL.	tet	85-87	collagen type I alpha 1 chain	Homo sapiens	50-72
25426938-9	2014	In the PAC1 Tet (tetracycline)-on inducible gene expression system by doxycycline (Dox), higher expression levels of PAC1 resulted in higher anti-apoptotic activities that were associated with a stronger Wnt/beta-catenin signal.	tet	12-15	adenylate cyclase activating polypeptide 1 receptor 1	Mus musculus	7-11
25195052-0	2014	Expression changes of antioxidant, apoptotic, anti-apoptotic genes and miR-15b-34a-21-98 in over tissue by using erythromycin, quinacrine and tetracycline in non-surgical sterilization.	tet	142-154	microRNA 15b	Rattus norvegicus	71-78
25426938-9	2014	In the PAC1 Tet (tetracycline)-on inducible gene expression system by doxycycline (Dox), higher expression levels of PAC1 resulted in higher anti-apoptotic activities that were associated with a stronger Wnt/beta-catenin signal.	tet	12-15	adenylate cyclase activating polypeptide 1 receptor 1	Mus musculus	117-121
25426938-9	2014	In the PAC1 Tet (tetracycline)-on inducible gene expression system by doxycycline (Dox), higher expression levels of PAC1 resulted in higher anti-apoptotic activities that were associated with a stronger Wnt/beta-catenin signal.	tet	17-29	adenylate cyclase activating polypeptide 1 receptor 1	Mus musculus	7-11
25426938-9	2014	In the PAC1 Tet (tetracycline)-on inducible gene expression system by doxycycline (Dox), higher expression levels of PAC1 resulted in higher anti-apoptotic activities that were associated with a stronger Wnt/beta-catenin signal.	tet	17-29	adenylate cyclase activating polypeptide 1 receptor 1	Mus musculus	117-121
25217527-4	2014	Utilizing a tetracycline-inducible lentivirus to elevate expression of miR100 in human cells, we found that increasing miR100 levels decreased the production of breast CSCs.	tet	12-24	microRNA 100	Homo sapiens	71-77
25316678-3	2014	To elucidate the downstream functions of activated NRAS in AML, we used a murine model that harbors Mll-AF9 and a tetracycline-repressible, activated NRAS (NRAS(G12V)).	tet	114-126	neuroblastoma ras oncogene	Mus musculus	51-55
25316678-3	2014	To elucidate the downstream functions of activated NRAS in AML, we used a murine model that harbors Mll-AF9 and a tetracycline-repressible, activated NRAS (NRAS(G12V)).	tet	114-126	neuroblastoma ras oncogene	Mus musculus	150-154
25217527-4	2014	Utilizing a tetracycline-inducible lentivirus to elevate expression of miR100 in human cells, we found that increasing miR100 levels decreased the production of breast CSCs.	tet	12-24	microRNA 100	Homo sapiens	119-125
25400545-3	2014	Here, we introduce a transgenic mouse model that combines the TRAP technique with the tetracycline transactivator (tTA) system by expressing EGFP-tagged ribosomal protein L10a (EGFP-L10a) under control of the tetracycline response element (tetO-TRAP).	tet	86-98	ribosomal protein L10A	Mus musculus	153-175
25363458-2	2014	We generated a transgenic tetracycline-inducible mouse line (called Atoh1-rtTA) using the Atoh1 enhancer to drive expression of the reverse tetracycline transactivator (rtTA) protein and human placental alkaline phosphatase.	tet	26-38	atonal bHLH transcription factor 1	Mus musculus	68-73
25363458-2	2014	We generated a transgenic tetracycline-inducible mouse line (called Atoh1-rtTA) using the Atoh1 enhancer to drive expression of the reverse tetracycline transactivator (rtTA) protein and human placental alkaline phosphatase.	tet	26-38	atonal bHLH transcription factor 1	Mus musculus	90-95
25289022-3	2014	Tie2-tTA directs expression of tetracycline-controlled transactivator (tTA) in endothelial and hematopoietic cells under the control of the Tie2 promoter.	tet	31-43	TEK receptor tyrosine kinase	Homo sapiens	0-4
25289022-3	2014	Tie2-tTA directs expression of tetracycline-controlled transactivator (tTA) in endothelial and hematopoietic cells under the control of the Tie2 promoter.	tet	31-43	TEK receptor tyrosine kinase	Homo sapiens	140-144
25289022-6	2014	In the presence of tetracycline, the tTA transactivator produced by Tie-2-tTA is disabled and Cre is not expressed.	tet	19-31	TEK receptor tyrosine kinase	Homo sapiens	68-73
25175815-6	2014	Inducible IC-Notch1 expression in adult mice was achieved by using tetracycline regulated Cre system.	tet	67-79	notch 1	Mus musculus	10-19
25175815-7	2014	The ZEG-IC-Notch1/Tie2-tTA/tet-O-Cre triple transgenic mice survived embryonic development when maintained on tetracycline.	tet	110-122	notch 1	Mus musculus	8-17
25175815-7	2014	The ZEG-IC-Notch1/Tie2-tTA/tet-O-Cre triple transgenic mice survived embryonic development when maintained on tetracycline.	tet	110-122	TEK receptor tyrosine kinase	Mus musculus	18-22
25175815-8	2014	Post-natal withdrawal of tetracycline induced expression of IC-Notch1 transgene in hematopoietic cells of adult mice.	tet	25-37	notch 1	Mus musculus	60-69
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	tet	23-35	glial cell derived neurotrophic factor	Homo sapiens	78-82
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	tet	23-35	glial cell derived neurotrophic factor	Homo sapiens	84-89
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	tet	23-35	glial cell derived neurotrophic factor	Homo sapiens	119-124
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	tet	37-40	glial cell derived neurotrophic factor	Homo sapiens	78-82
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	tet	37-40	glial cell derived neurotrophic factor	Homo sapiens	84-89
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	tet	37-40	glial cell derived neurotrophic factor	Homo sapiens	119-124
24997241-4	2014	Here we further examined the efficiency and neuroprotection of Tet-On lentivirus-mediated hGDNF gene regulation in neural progenitor cells (NPCs) and a rat model of parkinsonism.	tet	63-66	glial cell derived neurotrophic factor	Homo sapiens	90-95
24997241-7	2014	Intrastriatal injections of Tet-On lentivirus vectors resulted in dramatically increased levels of hGDNF protein in the striatum of rats with Dox-drinking water, when compared to lentivirus-injected and saline-injected rats with normal drinking water, respectively.	tet	28-31	glial cell derived neurotrophic factor	Homo sapiens	99-104
24997241-9	2014	To the best of our knowledge, this is the first report that hGDNF gene transfer by Tet-On lentivirus vectors is tightly regulated in rat brain, and Dox-induced hGDNF is functional in neuroprotection of nigral DA neurons in a rat model of parkinsonism.	tet	83-86	glial cell derived neurotrophic factor	Homo sapiens	60-65
25400545-3	2014	Here, we introduce a transgenic mouse model that combines the TRAP technique with the tetracycline transactivator (tTA) system by expressing EGFP-tagged ribosomal protein L10a (EGFP-L10a) under control of the tetracycline response element (tetO-TRAP).	tet	209-221	ribosomal protein L10A	Mus musculus	153-175
25092893-5	2014	Using a tetracycline-inducible Zap70 transgene (TetZap70), thymic development of Zap70-deficient TCR transgenic F5 mice was restored.	tet	8-20	zeta-chain (TCR) associated protein kinase	Mus musculus	31-36
25340787-4	2014	Deletion analysis confirmed that qnrS1 accounted for all the ciprofloxacin non-suceptibility conferred by pEBG1 and tetracycline and trimethoprim resistance could be attributed to tetAR and dfrA14 genes respectively.	tet	116-128	QnrS1	Escherichia coli	33-38
25339898-3	2014	In present study we tested whether cells with the tetracycline-off inducible overexpression of alpha-syn and accumulating alpha-syn aggregates can benefit from autophagy activation elicited by nutrient deprivation (ND), since this approach was reported to effectively clear cellular polyglutamine aggregates.	tet	50-62	synuclein alpha	Homo sapiens	95-104
25119854-3	2014	In the present study, we engineered rat mesenchymal stem cells (MSCs) to express type 2 angiotensin II receptor (AT2R) using a tetracycline-regulated system that can strictly regulate AT2R expression.	tet	127-139	angiotensin II receptor, type 2	Rattus norvegicus	81-111
25119854-3	2014	In the present study, we engineered rat mesenchymal stem cells (MSCs) to express type 2 angiotensin II receptor (AT2R) using a tetracycline-regulated system that can strictly regulate AT2R expression.	tet	127-139	angiotensin II receptor, type 2	Rattus norvegicus	113-117
25119854-3	2014	In the present study, we engineered rat mesenchymal stem cells (MSCs) to express type 2 angiotensin II receptor (AT2R) using a tetracycline-regulated system that can strictly regulate AT2R expression.	tet	127-139	angiotensin II receptor, type 2	Rattus norvegicus	184-188
25299602-6	2014	To determine the cellular function of Arp8, we derived tetracycline-inducible Arp8 knockout cells from a cultured human cell line.	tet	55-67	actin related protein 8	Homo sapiens	38-42
25299602-6	2014	To determine the cellular function of Arp8, we derived tetracycline-inducible Arp8 knockout cells from a cultured human cell line.	tet	55-67	actin related protein 8	Homo sapiens	78-82
25145495-7	2014	Additionally, using a chequerboard assay, we have shown that hepcidin has an antagonistic effect in combination with the antibiotics rifampicin and tetracycline against Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus pyogenes, evidenced by a fractional inhibitory concentration index (FICI) &gt; 4.	tet	148-160	hepcidin antimicrobial peptide	Homo sapiens	61-69
25092893-5	2014	Using a tetracycline-inducible Zap70 transgene (TetZap70), thymic development of Zap70-deficient TCR transgenic F5 mice was restored.	tet	8-20	T cell receptor alpha variable 6-3	Mus musculus	97-100
24728940-5	2014	To design this system for regulation of GDNF expression, we transduced two lentiviral vectors, one containing a constitutively active GDNF transgene flanked by two loxP sites, and the other containing a tetracycline-inducible cre transgene along with its constitutively active transactivator, into Schwann cells (SCs).	tet	203-215	glial cell derived neurotrophic factor	Homo sapiens	40-44
24881817-3	2014	By using tetracycline repressive LIP expression constructs, we found that SCp2 cells, a clonal epithelial line of COMMA1-D cells, expressed EMT markers, lost the ability to undergo alveolar-like morphogenesis in 3D Matrigel, and acquired properties of benign adenoma cells.	tet	9-21	sterol carrier protein 2, liver	Mus musculus	74-78
25008904-3	2014	We show that infection-induced T-cell exhaustion, characterized as loss of antigen-specific proliferation, and gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production are partially restored in cattle following clearance of persistent infection with tetracycline.	tet	277-289	interferon gamma	Bos taurus	111-138
25107671-5	2014	Arteriole density was significantly higher in the peri-infarct area of hSCF/tetracycline transactivator mice compared with wild-type mice 5 days post MI.	tet	76-88	KIT ligand	Homo sapiens	71-75
25008904-3	2014	We show that infection-induced T-cell exhaustion, characterized as loss of antigen-specific proliferation, and gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production are partially restored in cattle following clearance of persistent infection with tetracycline.	tet	277-289	tumor necrosis factor	Bos taurus	144-171
25008904-3	2014	We show that infection-induced T-cell exhaustion, characterized as loss of antigen-specific proliferation, and gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production are partially restored in cattle following clearance of persistent infection with tetracycline.	tet	277-289	tumor necrosis factor	Bos taurus	173-182
24972115-6	2014	The detected genes were blaZ; erm(A)-erm(B)-erm(C)-msr(A)-msr(B)-lnu(A), aphA-aadE-sat4-aacA + aphD-aadD, tet(K), cat, and qacA/B, for resistance to ampicillin, macrolides and/or lincosamides, aminoglycosides, tetracycline, chloramphenicol, and quaternary ammonium compounds, respectively.	tet	210-222	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	24-28
24919035-1	2014	The ZHTc6-MyoD embryonic stem cell line expresses the myogenic transcriptional factor MyoD under the control of a tetracycline-inducible promoter.	tet	114-126	myogenic differentiation 1	Mus musculus	10-14
24909488-1	2014	We established a cell line (HEK-hMel) expressing melanopsin in a tetracycline dependent manner to elucidate new aspects of melanopsin"s light response.	tet	65-77	opsin 4	Homo sapiens	49-59
25090270-6	2014	To induce the expression of the most common HGPS mutation, LMNA c.1824C&gt;T; p.G608G, in the vascular smooth muscle cells of the aortic arch and thoracic aorta, we used the previously described reverse tetracycline-controlled transactivator, sm22alpha-rtTA.	tet	203-215	lamin A/C	Homo sapiens	59-63
24848360-6	2014	We generated a binary transgenic (BTG) mouse that selectively expresses TRalpha1 in endothelial cells in a tetracycline-inducible fashion.	tet	107-119	thyroid hormone receptor alpha	Mus musculus	72-80
24859238-3	2014	Using the human insulin promoter region, a doxycycline (dox)-inducible ICER Igamma expression system was established using the tetracycline (tet)-controlled transactivator (tTA) with a TA response element (TRE) promoter.	tet	127-139	insulin	Homo sapiens	16-23
24859238-3	2014	Using the human insulin promoter region, a doxycycline (dox)-inducible ICER Igamma expression system was established using the tetracycline (tet)-controlled transactivator (tTA) with a TA response element (TRE) promoter.	tet	127-139	cAMP responsive element modulator	Homo sapiens	71-75
24859238-3	2014	Using the human insulin promoter region, a doxycycline (dox)-inducible ICER Igamma expression system was established using the tetracycline (tet)-controlled transactivator (tTA) with a TA response element (TRE) promoter.	tet	127-130	insulin	Homo sapiens	16-23
24859238-3	2014	Using the human insulin promoter region, a doxycycline (dox)-inducible ICER Igamma expression system was established using the tetracycline (tet)-controlled transactivator (tTA) with a TA response element (TRE) promoter.	tet	127-130	cAMP responsive element modulator	Homo sapiens	71-75
24859238-4	2014	A unitary tet-on system that combined a tet-on activator cassette was also developed and was controlled by the human insulin promoter with a responder cassette containing genes encoding ICER Igamma regulated by the TRE promoter.	tet	10-13	insulin	Homo sapiens	117-124
24859238-4	2014	A unitary tet-on system that combined a tet-on activator cassette was also developed and was controlled by the human insulin promoter with a responder cassette containing genes encoding ICER Igamma regulated by the TRE promoter.	tet	10-13	cAMP responsive element modulator	Homo sapiens	186-190
24859238-4	2014	A unitary tet-on system that combined a tet-on activator cassette was also developed and was controlled by the human insulin promoter with a responder cassette containing genes encoding ICER Igamma regulated by the TRE promoter.	tet	40-43	insulin	Homo sapiens	117-124
24859238-5	2014	To determine whether dox-enhanced ICER Igamma expression affected insulin production, the unitary tet-on ICER Igamma vector was introduced into a mouse pancreatic beta-cell line and then the cells were treated with 0.1-1 mg/ml dox.	tet	98-101	cAMP responsive element modulator	Homo sapiens	105-109
24805236-3	2014	To determine whether continued PTEN inactivation is required to maintain malignancy, here we generate an RNA interference-based transgenic mouse model that allows tetracycline-dependent regulation of PTEN in a time- and tissue-specific manner.	tet	163-175	phosphatase and tensin homolog	Mus musculus	200-204
24919035-1	2014	The ZHTc6-MyoD embryonic stem cell line expresses the myogenic transcriptional factor MyoD under the control of a tetracycline-inducible promoter.	tet	114-126	myogenic differentiation 1	Mus musculus	86-90
24648416-3	2014	To explore this in a human model system, YB-1 was expressed in mammary epithelial cells under the control of a tetracycline-inducible promoter.	tet	111-123	Y-box binding protein 1	Homo sapiens	41-45
24668812-3	2014	In this study, we generated novel tetracycline-inducible Madin-Darby canine kidney type I (MDCKI) cell lines expressing NCC to examine the role of NCC phosphorylation and ubiquitylation on NCC endocytosis.	tet	34-46	solute carrier family 12 member 3	Homo sapiens	120-123
24831790-6	2014	Our assay utilizes cell lines stably expressing a GnRHR mutant under the control of a tetracycline (OFF) transactivator.	tet	86-98	gonadotropin releasing hormone receptor	Homo sapiens	50-55
24369117-3	2014	Based on our previous work identifying DGKtheta as the enzyme that produces the agonist for SF1, we generated a tetracycline-inducible H295R stable cell line to express a short hairpin RNA (shRNA) against DGKtheta and characterized the effect of silencing DGKtheta on adrenocortical gene expression.	tet	112-124	splicing factor 1	Homo sapiens	92-95
24803658-6	2014	Induction of En2 misexpression using a tetracycline-inducible system after the postmitotic cells had reached superficial layers also resulted in disappearance of En2-expressing cells from the superficial layers.	tet	39-51	engrailed homeobox 2	Gallus gallus	13-16
24803658-6	2014	Induction of En2 misexpression using a tetracycline-inducible system after the postmitotic cells had reached superficial layers also resulted in disappearance of En2-expressing cells from the superficial layers.	tet	39-51	engrailed homeobox 2	Gallus gallus	162-165
24369117-3	2014	Based on our previous work identifying DGKtheta as the enzyme that produces the agonist for SF1, we generated a tetracycline-inducible H295R stable cell line to express a short hairpin RNA (shRNA) against DGKtheta and characterized the effect of silencing DGKtheta on adrenocortical gene expression.	tet	112-124	diacylglycerol kinase theta	Homo sapiens	205-213
24369117-3	2014	Based on our previous work identifying DGKtheta as the enzyme that produces the agonist for SF1, we generated a tetracycline-inducible H295R stable cell line to express a short hairpin RNA (shRNA) against DGKtheta and characterized the effect of silencing DGKtheta on adrenocortical gene expression.	tet	112-124	diacylglycerol kinase theta	Homo sapiens	39-47
24369117-3	2014	Based on our previous work identifying DGKtheta as the enzyme that produces the agonist for SF1, we generated a tetracycline-inducible H295R stable cell line to express a short hairpin RNA (shRNA) against DGKtheta and characterized the effect of silencing DGKtheta on adrenocortical gene expression.	tet	112-124	diacylglycerol kinase theta	Homo sapiens	205-213
24639514-3	2014	Based on previous genetic memory systems, we constructed a two-part system with a "trigger element" in which the lambda Cro gene is transcribed from a tetracycline-inducible promoter, and a "memory element" derived from the cI/Cro region of phage lambda.	tet	151-163	cro	Escherichia virus Lambda	120-123
24569460-4	2014	This screen initially identified tetracycline as a potential AKR1C3-selective inhibitor.	tet	33-45	aldo-keto reductase family 1 member C3	Homo sapiens	61-67
24440599-3	2014	To answer this crucial question we have generated transgenic mice that express IDH2(R140Q) in an on/off- and tissue-specific manner using a tetracycline-inducible system.	tet	140-152	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	79-83
24569460-9	2014	CONCLUSIONS: In summary, we have identified a novel tetracycline-derived product that provides an excellent lead structure with proven drug-like qualities for the development of AKR1C3 inhibitors.	tet	52-64	aldo-keto reductase family 1 member C3	Homo sapiens	178-184
24407945-2	2014	The T4L variant of human FPR3 termed FPR3-T4L was expressed in stable tetracycline-inducible HEK293 cells.	tet	70-82	formyl peptide receptor 3	Homo sapiens	25-29
24634581-1	2014	Inhibition of soluble matrix metalloproteinase (MMP) activity is among the non-antibiotic cellular effects exerted by the anti-inflammatory tetracycline derivative minocycline.	tet	140-152	matrix metallopeptidase 14	Homo sapiens	48-51
24407945-2	2014	The T4L variant of human FPR3 termed FPR3-T4L was expressed in stable tetracycline-inducible HEK293 cells.	tet	70-82	formyl peptide receptor 3	Homo sapiens	37-41
24462722-3	2014	Two constructs containing the reverse tetracycline-controlled transcriptional transactivator (rtTA) gene driven by the UV opsin-specific promoter (opn1sw1) were used to generate stable transgenic zebrafish lines using the Tol2-based transgenesis method.	tet	38-50	opsin 1 (cone pigments), short-wave-sensitive 1	Danio rerio	147-154
24292262-3	2014	Lung adenocarcinoma cell lines were exposed to minocycline, followed by incubation at hypoxic condition for 3-6 h. Here, we show that minocycline, a second-generation tetracycline, can induce HIF-1alpha proteasomal degradation under hypoxia by increasing the expression prolyl hydroxylase-2 and HIF-1alpha/von Hippel-Lindau protein interaction, thereby overcoming hypoxia-induced HIF-1alpha stabilization.	tet	167-179	hypoxia inducible factor 1 subunit alpha	Homo sapiens	192-202
24316150-8	2014	Cu exposure, or intracellular Cu accumulation following the tetracycline (Tet)-induced overexpression of CTR1, did not result in significant change in ATP7A expression.	tet	60-72	solute carrier family 31 member 1	Homo sapiens	105-109
24824125-1	2014	OBJECTIVE: To study the role of tumor necrosis factor-alpha (TNFalpha) in the anti-replication effects of tetracycline (Tet) on hepatitis B virus (HBV).	tet	106-118	tumor necrosis factor	Homo sapiens	61-69
24429550-4	2014	METHODS AND RESULTS: Administration of doxycycline to Clara cell secretory protein-reverse tetracycline-controlled transactivator/tetracycline operator-VEGF-C double-transgenic mice during a critical period from embryonic day 15.5 to postnatal day 14 was accompanied by respiratory distress, chylothorax, pulmonary lymphangiectasia, and high mortality.	tet	130-142	vascular endothelial growth factor C	Mus musculus	152-158
24316150-8	2014	Cu exposure, or intracellular Cu accumulation following the tetracycline (Tet)-induced overexpression of CTR1, did not result in significant change in ATP7A expression.	tet	74-77	solute carrier family 31 member 1	Homo sapiens	105-109
24321708-2	2014	Here, the potential regulating tetracycline expression (Tet-on) system was used to express Sox9 both in vivo and in vitro.	tet	31-43	SRY-box transcription factor 9	Rattus norvegicus	91-95
24462858-4	2014	We inserted a tetracycline-regulated inducible gene promoter (tet-OFF/TRE-CMV) upstream of the endogenous promoter region of vascular endothelial growth factor receptor 2 (VEGFR2/Flk1) gene, an essential gene for endothelial cell (EC) differentiation, in mouse embryonic stem cells (ESCs) with homologous recombination.	tet	14-26	kinase insert domain protein receptor	Mus musculus	125-170
24462858-4	2014	We inserted a tetracycline-regulated inducible gene promoter (tet-OFF/TRE-CMV) upstream of the endogenous promoter region of vascular endothelial growth factor receptor 2 (VEGFR2/Flk1) gene, an essential gene for endothelial cell (EC) differentiation, in mouse embryonic stem cells (ESCs) with homologous recombination.	tet	14-26	kinase insert domain protein receptor	Mus musculus	172-178
24462858-4	2014	We inserted a tetracycline-regulated inducible gene promoter (tet-OFF/TRE-CMV) upstream of the endogenous promoter region of vascular endothelial growth factor receptor 2 (VEGFR2/Flk1) gene, an essential gene for endothelial cell (EC) differentiation, in mouse embryonic stem cells (ESCs) with homologous recombination.	tet	14-26	kinase insert domain protein receptor	Mus musculus	179-183
24282291-6	2014	METHODS AND RESULTS: We took advantage of a mouse model with site-specific insertion of a tetracycline-based genetic switch in the 5" untranslated region of the KCNN3 (SK3 channel) gene (SK3(T/T)).	tet	90-102	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	161-166
24282291-6	2014	METHODS AND RESULTS: We took advantage of a mouse model with site-specific insertion of a tetracycline-based genetic switch in the 5" untranslated region of the KCNN3 (SK3 channel) gene (SK3(T/T)).	tet	90-102	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	168-171
24282291-6	2014	METHODS AND RESULTS: We took advantage of a mouse model with site-specific insertion of a tetracycline-based genetic switch in the 5" untranslated region of the KCNN3 (SK3 channel) gene (SK3(T/T)).	tet	90-102	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	187-190
24489787-11	2014	Some of the differentially expressed genes were considered as potential candidate biomarkers to identify PPAR agonists (i.e. AMI and VA) or compounds impairing mitochondrial functions (i.e. TET).	tet	190-193	peroxisome proliferator activated receptor alpha	Mus musculus	105-109
24678266-7	2014	One tc-RS variant resulted in more than 11-fold tetracycline-dependent regulation of bla expression, which is in the range of regulation by naturally occurring riboswitches.	tet	48-60	beta-lactamase	Escherichia coli	85-88
24689432-5	2014	The tetO gene was found in all of the tetracycline-resistant isolates.	tet	38-50	tetO	Campylobacter coli	4-8
24280420-6	2014	Furthermore, we observed that long term tetracycline incubation also caused inhibition of the mTOR complex, a central regulator of cell metabolism, further contributing to the observed cell-cycle arrest and autophagy in doxycycline- and minocycline-treated cell lines.	tet	40-52	mechanistic target of rapamycin kinase	Homo sapiens	94-98
24429108-5	2014	In the tetracycline-regulated expression system of ClC-5 in the HEK293 cells stably expressing gastric H(+),K(+)-ATPase, ClC-5 was co-immunoprecipitated with H(+),K(+)-ATPase, but not with endogenous Na(+),K(+)-ATPase.	tet	7-19	chloride voltage-gated channel 5	Homo sapiens	51-56
24429108-5	2014	In the tetracycline-regulated expression system of ClC-5 in the HEK293 cells stably expressing gastric H(+),K(+)-ATPase, ClC-5 was co-immunoprecipitated with H(+),K(+)-ATPase, but not with endogenous Na(+),K(+)-ATPase.	tet	7-19	chloride voltage-gated channel 5	Homo sapiens	121-126
25424794-9	2014	Serotype 19A was less susceptible to penicillin (80.0 vs 91.2%, P = 0.046), cefditoren (66.7 vs 95.5% by Spanish breakpoints, P = 0.004), and tetracycline (9.1 vs 45.5%, P = 0.024) than non-19A isolates.	tet	142-154	SLAM family member 7	Homo sapiens	9-12
25786374-1	2013	We report the controlled release of the antibiotic tetracycline (Tet) from triple-layered (3L) electrospun matrices consisting of zein or a zein/PCL blend, where the drug was loaded into the central layer with the two outer layers acting as diffusion barriers.	tet	51-63	tetracycline-resistance protein	Staphylococcus aureus	65-68
25104884-1	2014	Tetracycline-based matrix metalloproteinase- (MMP-) inhibitors are currently approved for two inflammatory diseases, periodontitis and rosacea.	tet	0-12	matrix metallopeptidase 8	Rattus norvegicus	46-49
24190282-7	2014	Tetracycline on/off transfected cell lines exhibited a lower relative expression of antiapoptotic Bcl-2 compared with their originating LYD cells.	tet	0-12	BCL2 apoptosis regulator	Homo sapiens	98-103
24047647-10	2013	Resistance genes detected included tet(M) and/or tet(L), ermB in all tetracycline and erythromycin-resistant isolates.	tet	69-81	rRNA adenine N-6-methyltransferase	Escherichia coli	57-61
24047647-12	2013	The blaTEM, aadA, aadA5, strA, strB, tet(A) and/or tet(B), and the intI genes were found in all ampicillin, streptomycin, tetracycline, and sulfamethoxazole/trimethoprim-resistant isolates respectively.	tet	122-134	aadA5	Escherichia coli	18-23
23965989-5	2013	We overexpressed human eNOS W447A and W447F mutants in novel cell lines with tetracycline-regulated expression of human GTP cyclohydrolase I, the rate-limiting enzyme in BH4 synthesis, to determine the importance of BH4 and Trp-447 in eNOS uncoupling.	tet	77-89	nitric oxide synthase 3	Homo sapiens	23-27
24386508-6	2013	We observed significant tumor formation in Ink4a/Arf(lox/lox) mice injected with retroviruses containing tetracycline responsive element (TRE)-KRas, Tet-off, Akt, and Cre.	tet	105-117	cyclin dependent kinase inhibitor 2A	Mus musculus	43-48
24386508-6	2013	We observed significant tumor formation in Ink4a/Arf(lox/lox) mice injected with retroviruses containing tetracycline responsive element (TRE)-KRas, Tet-off, Akt, and Cre.	tet	105-117	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	143-147
23867236-6	2013	We used a tetracycline-suppressive (tet-off) transgenic mouse model that restricts overexpression of human A30P alpha-syn to neurons owing to usage of the neuron-specific CaMKIIalpha promoter.	tet	10-22	synuclein alpha	Homo sapiens	112-121
24047201-2	2013	Employing a total synthetic approach allowed for modifications at the C-7 and C-8 positions, enabling the generation of structure-activity relationships for overcoming the two most common tetracycline bacterial-resistance mechanisms: ribosomal protection (tet(M)) and efflux (tet(A)).	tet	188-200	complement component 7	Mus musculus	70-73
24047201-2	2013	Employing a total synthetic approach allowed for modifications at the C-7 and C-8 positions, enabling the generation of structure-activity relationships for overcoming the two most common tetracycline bacterial-resistance mechanisms: ribosomal protection (tet(M)) and efflux (tet(A)).	tet	188-200	cell division cycle associated 3	Mus musculus	78-81
24238102-3	2013	METHODS: We have used a tetracycline-inducible Ets-1 overexpression model derived from 2008 ovarian cancer cells in the present study.	tet	24-36	ETS proto-oncogene 1, transcription factor	Homo sapiens	47-52
24266659-4	2013	A fluorescence-based thallium (Tl(+)) flux assay that utilizes a tetracycline-inducible T-Rex-HEK293-Kir4.1 cell line to enable high-throughput screening (HTS) of small-molecule libraries was developed.	tet	65-77	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	101-107
23965989-5	2013	We overexpressed human eNOS W447A and W447F mutants in novel cell lines with tetracycline-regulated expression of human GTP cyclohydrolase I, the rate-limiting enzyme in BH4 synthesis, to determine the importance of BH4 and Trp-447 in eNOS uncoupling.	tet	77-89	GTP cyclohydrolase 1	Homo sapiens	120-140
23965989-5	2013	We overexpressed human eNOS W447A and W447F mutants in novel cell lines with tetracycline-regulated expression of human GTP cyclohydrolase I, the rate-limiting enzyme in BH4 synthesis, to determine the importance of BH4 and Trp-447 in eNOS uncoupling.	tet	77-89	nitric oxide synthase 3	Homo sapiens	235-239
23846031-7	2013	Genotypes and antimicrobial susceptibility patterns (tetracycline resistance in ST398 and clindamycin-erythromycin-tetracycline resistance in ST1) suggest that the MRSA found probably originated in livestock (ST398) or humans (ST1).	tet	115-127	syndecan binding protein	Homo sapiens	142-145
23858099-2	2013	Minocycline, a tetracycline, has been shown to exhibit beneficial effects in this malignancy through regulation of a cohort of genes that overlap significantly with the NF-kappaB transcriptome.	tet	15-27	nuclear factor kappa B subunit 1	Homo sapiens	169-178
23885065-4	2013	In Madin-Darby canine kidney cells stably expressing epitope-tagged alphabetagamma-ENaC and with tetracycline-inducible overexpression of Hsc70, treatment with 5 mug/ml doxycycline increased total Hsc70 expression 20%.	tet	97-109	heat shock protein family A (Hsp70) member 1 like S homeolog	Xenopus laevis	138-143
23463365-4	2013	In this study, Sox21 was overexpressed by using a tetracycline-regulated expression system (tet-on) in glioma cells.	tet	50-62	SRY-box transcription factor 21	Homo sapiens	15-20
23988330-5	2013	Our SMART (safety mechanism assisted by the repressor of tetracycline) vectors are designed to express the tetracycline repressor under a constitutive VACV promoter and IFN-gamma under engineered tetracycline-inducible promoters.	tet	57-69	interferon gamma	Mus musculus	169-178
23988330-8	2013	In this study, we developed a safety mechanism for VACV based on the conditional expression of IFN-gamma under a tightly controlled tetracycline-inducible VACV promoter for use in vaccines and oncolytic cancer therapies.	tet	132-144	interferon gamma	Mus musculus	95-104
24086556-6	2013	Gp91(phox-/-) 6-OHDA-lesioned mice treated with minocycline, a tetracycline derivative that exerts multiple anti-inflammatory effects, including microglial inhibition, exhibited increased apomorphine-induced rotational behavior and degeneration of DA neurons after 6-OHDA injections.	tet	63-75	paired Ig-like receptor B	Mus musculus	0-4
23983821-1	2013	We have developed a tetracycline (tet)-off regulated expression of CD44s gene in the breast cancer (BC) cell line MCF-7 (B5 clone) and identified TGF-beta2 (Transforming Growth Factor beta-2; 3 fold induction) as a potential CD44-downstream transcriptional target by microarray analysis.	tet	20-32	CD44 molecule (Indian blood group)	Homo sapiens	67-71
23514706-7	2013	Under the control of the HIF1alpha-HRE and Tet-On gene control systems, the expression of the exogenous hVEGF165 and Ang-1 genes was consistent in the ischemia control.	tet	43-46	angiopoietin 1	Homo sapiens	117-122
23774624-6	2013	To this end we focused our study on HeLa cells carrying a tetracycline-repressible plasmid system which shuts down Pgp expression in the presence of tetracycline.	tet	58-70	ATP binding cassette subfamily B member 1	Homo sapiens	115-118
23774624-6	2013	To this end we focused our study on HeLa cells carrying a tetracycline-repressible plasmid system which shuts down Pgp expression in the presence of tetracycline.	tet	149-161	ATP binding cassette subfamily B member 1	Homo sapiens	115-118
23570903-3	2013	293 cells or C17.2 cells were transduced with a lentiviral vector encoding the fluorescent reporter mCherry and bFGF under tetracycline-regulated transgene expression (Tet-ON).	tet	123-135	fibroblast growth factor 2	Mus musculus	112-116
23680332-0	2013	Human T47D-ERbeta breast cancer cells with tetracycline-dependent ERbeta expression reflect ERalpha/ERbeta ratios in rat and human breast tissue.	tet	43-55	estrogen receptor 2	Rattus norvegicus	11-17
23680332-0	2013	Human T47D-ERbeta breast cancer cells with tetracycline-dependent ERbeta expression reflect ERalpha/ERbeta ratios in rat and human breast tissue.	tet	43-55	estrogen receptor 1	Rattus norvegicus	92-99
23680332-0	2013	Human T47D-ERbeta breast cancer cells with tetracycline-dependent ERbeta expression reflect ERalpha/ERbeta ratios in rat and human breast tissue.	tet	43-55	estrogen receptor 2	Rattus norvegicus	66-72
23680332-1	2013	T47D-ERbeta breast cancer cells with tetracycline-dependent ERbeta expression and constant ERalpha expression can be used to investigate effects of varying ERalpha/ERbeta ratios on estrogen-induced cellular responses.	tet	37-49	estrogen receptor 2	Homo sapiens	5-11
23680332-1	2013	T47D-ERbeta breast cancer cells with tetracycline-dependent ERbeta expression and constant ERalpha expression can be used to investigate effects of varying ERalpha/ERbeta ratios on estrogen-induced cellular responses.	tet	37-49	estrogen receptor 2	Homo sapiens	60-66
23680332-3	2013	Protein and mRNA levels of ERalpha and ERbeta were analyzed in T47D-ERbeta cells exposed to a range of tetracycline concentrations and compared to ERalpha and ERbeta levels found in breast, prostate, and uterus from rat and human origin.	tet	103-115	estrogen receptor 1	Rattus norvegicus	27-34
23680332-4	2013	The ERalpha/ERbeta ratio in T47D-ERbeta cells exposed to &gt;150ng/ml tetracycline is comparable to the ratio found in rat mammary gland and in human breast tissue.	tet	70-82	estrogen receptor 1	Rattus norvegicus	4-11
23680332-4	2013	The ERalpha/ERbeta ratio in T47D-ERbeta cells exposed to &gt;150ng/ml tetracycline is comparable to the ratio found in rat mammary gland and in human breast tissue.	tet	70-82	estrogen receptor 2	Rattus norvegicus	12-18
23680332-4	2013	The ERalpha/ERbeta ratio in T47D-ERbeta cells exposed to &gt;150ng/ml tetracycline is comparable to the ratio found in rat mammary gland and in human breast tissue.	tet	70-82	estrogen receptor 2	Rattus norvegicus	33-39
23987100-2	2013	METHODS: We developed a transgenic mouse line in which expression of an oxygen-stable HIF-1alpha construct was controlled by a tetracycline-responsive promoter.	tet	127-139	hypoxia inducible factor 1, alpha subunit	Mus musculus	86-96
23983821-1	2013	We have developed a tetracycline (tet)-off regulated expression of CD44s gene in the breast cancer (BC) cell line MCF-7 (B5 clone) and identified TGF-beta2 (Transforming Growth Factor beta-2; 3 fold induction) as a potential CD44-downstream transcriptional target by microarray analysis.	tet	20-32	transforming growth factor beta 2	Homo sapiens	146-155
23983821-1	2013	We have developed a tetracycline (tet)-off regulated expression of CD44s gene in the breast cancer (BC) cell line MCF-7 (B5 clone) and identified TGF-beta2 (Transforming Growth Factor beta-2; 3 fold induction) as a potential CD44-downstream transcriptional target by microarray analysis.	tet	20-32	transforming growth factor beta 2	Homo sapiens	157-190
23983821-1	2013	We have developed a tetracycline (tet)-off regulated expression of CD44s gene in the breast cancer (BC) cell line MCF-7 (B5 clone) and identified TGF-beta2 (Transforming Growth Factor beta-2; 3 fold induction) as a potential CD44-downstream transcriptional target by microarray analysis.	tet	20-32	CD44 molecule (Indian blood group)	Homo sapiens	225-229
23983821-1	2013	We have developed a tetracycline (tet)-off regulated expression of CD44s gene in the breast cancer (BC) cell line MCF-7 (B5 clone) and identified TGF-beta2 (Transforming Growth Factor beta-2; 3 fold induction) as a potential CD44-downstream transcriptional target by microarray analysis.	tet	20-23	CD44 molecule (Indian blood group)	Homo sapiens	67-71
23983821-1	2013	We have developed a tetracycline (tet)-off regulated expression of CD44s gene in the breast cancer (BC) cell line MCF-7 (B5 clone) and identified TGF-beta2 (Transforming Growth Factor beta-2; 3 fold induction) as a potential CD44-downstream transcriptional target by microarray analysis.	tet	20-23	transforming growth factor beta 2	Homo sapiens	157-190
23983821-1	2013	We have developed a tetracycline (tet)-off regulated expression of CD44s gene in the breast cancer (BC) cell line MCF-7 (B5 clone) and identified TGF-beta2 (Transforming Growth Factor beta-2; 3 fold induction) as a potential CD44-downstream transcriptional target by microarray analysis.	tet	20-23	CD44 molecule (Indian blood group)	Homo sapiens	225-229
23983821-3	2013	Our results showed that TGF-beta2 mRNA levels were significantly elevated following the removal of tetracycline at 18, 24, and 48 h post-HA stimulation compared to the parental cells.	tet	99-111	transforming growth factor beta 2	Homo sapiens	24-33
23874609-6	2013	To address this issue, we generated a transgenic mouse line with tetracycline-regulated ATF3 cardiac expression.	tet	65-77	activating transcription factor 3	Mus musculus	88-92
23553029-2	2013	A SGC-7901 cell system with tetracycline-inducible ECRG4 expression (SGC-7901/ECRG4) was successfully established.	tet	28-40	ECRG4 augurin precursor	Homo sapiens	51-56
23553029-2	2013	A SGC-7901 cell system with tetracycline-inducible ECRG4 expression (SGC-7901/ECRG4) was successfully established.	tet	28-40	ECRG4 augurin precursor	Homo sapiens	78-83
23553029-5	2013	ECRG4 mRNA and protein expression levels were significantly upregulated in SGC-7901/ECRG4 cells induced with tetracycline.	tet	109-121	ECRG4 augurin precursor	Homo sapiens	0-5
23553029-5	2013	ECRG4 mRNA and protein expression levels were significantly upregulated in SGC-7901/ECRG4 cells induced with tetracycline.	tet	109-121	ECRG4 augurin precursor	Homo sapiens	84-89
23874405-9	2013	Finally, in a cell line with a tetracycline-regulated c-MYC gene, diclofenac decreased proliferation both in the presence and absence of c-MYC.	tet	31-43	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	54-59
23824974-3	2013	In the Fmr1 knock-out (KO), a mouse model of FXS, an abnormal elevated expression of MMP-9 in the brain was pharmacologically down-regulated after treatment with the tetracycline derivative minocycline.	tet	166-178	fragile X messenger ribonucleoprotein 1	Homo sapiens	7-11
23824974-3	2013	In the Fmr1 knock-out (KO), a mouse model of FXS, an abnormal elevated expression of MMP-9 in the brain was pharmacologically down-regulated after treatment with the tetracycline derivative minocycline.	tet	166-178	matrix metallopeptidase 9	Mus musculus	85-90
23710822-7	2013	Using Tramp-C1 and PTENCaP8 cells with a tetracycline-inducible expression of BMP-6, the induction of BMP-6 in vivo resulted in a significant resistance to castration.	tet	41-53	bone morphogenetic protein 6	Mus musculus	78-83
23710822-7	2013	Using Tramp-C1 and PTENCaP8 cells with a tetracycline-inducible expression of BMP-6, the induction of BMP-6 in vivo resulted in a significant resistance to castration.	tet	41-53	bone morphogenetic protein 6	Mus musculus	102-107
23879707-2	2013	Resistance to tetracycline (tet(M)), chloramphenicol (cat) and macrolides (erm(B) and/or mef(A/E)) is generally conferred by acquisition of specific genes that are associated with mobile genetic elements, including those of the Tn916 and Tn5252 families.	tet	14-26	E74 like ETS transcription factor 4	Homo sapiens	89-92
23852019-4	2013	Using a tetracycline-inducible expression system, we successfully overexpressed functional hTSHR on bacterial magnetic particles (BacMPs) in AMB-1 via an anchor protein specific for BacMPs.	tet	8-20	thyroid stimulating hormone receptor	Homo sapiens	91-96
23564016-8	2013	Tetracycline-induced FDPS silencing caused a significant decrease in the Cl(-) current.	tet	0-12	farnesyl diphosphate synthetase	Mus musculus	21-25
24018842-4	2013	We have generated a novel binary (Tet-ON/OFF) conditional transgenic mouse (Tet-Nox2:VE-Cad-tTA) that induces endothelial cell (EC)-specific overexpression of Nox2/gp91 (NADPH oxidase) and 1.8?0.42-fold increase in EC-ROS upon tetracycline withdrawal (Tet-OFF).	tet	227-239	cytochrome b-245, beta polypeptide	Mus musculus	159-163
24018842-4	2013	We have generated a novel binary (Tet-ON/OFF) conditional transgenic mouse (Tet-Nox2:VE-Cad-tTA) that induces endothelial cell (EC)-specific overexpression of Nox2/gp91 (NADPH oxidase) and 1.8?0.42-fold increase in EC-ROS upon tetracycline withdrawal (Tet-OFF).	tet	227-239	paired Ig-like receptor B	Mus musculus	164-168
23618876-11	2013	Using the T47D-estrogen receptor beta tetracycline-inducible cell line, the results confirmed that when the overexpression of estrogen receptor beta was inhibited, there was an increase in mitochondrial biogenesis, although these mitochondria were less functional, and with fewer fission events, although there was an increase in fusion processes.	tet	38-50	estrogen receptor 2	Homo sapiens	15-37
23618876-11	2013	Using the T47D-estrogen receptor beta tetracycline-inducible cell line, the results confirmed that when the overexpression of estrogen receptor beta was inhibited, there was an increase in mitochondrial biogenesis, although these mitochondria were less functional, and with fewer fission events, although there was an increase in fusion processes.	tet	38-50	estrogen receptor 2	Homo sapiens	126-148
23776652-6	2013	However, the single tet-off lentiviral vector carrying the EF-1alpha promoter provided more homogenous expression of EGFP in hADMPCs.	tet	20-23	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	59-68
23526584-3	2013	In the SF2575 biosynthetic pathway, SsfS6 has been implicated as the crucial C-glycosyltransferase (C-GT) that forms the C-C glycosidic bond between the sugar and the SF2575 tetracycline-like scaffold.	tet	174-186	UDP galactosyltransferase 8A	Mus musculus	77-98
23526584-3	2013	In the SF2575 biosynthetic pathway, SsfS6 has been implicated as the crucial C-glycosyltransferase (C-GT) that forms the C-C glycosidic bond between the sugar and the SF2575 tetracycline-like scaffold.	tet	174-186	UDP galactosyltransferase 8A	Mus musculus	100-104
23730214-3	2013	Furthermore, using epithelial cell lines expressing CD74 under the control of tetracycline-inducible promoter and quantitative high-resolution mass spectrometry, we demonstrate that, as a result of CD74 overexpression, the phosphorylation pattern of the C-terminal part of Scribble undergoes specific changes.	tet	78-90	CD74 molecule	Homo sapiens	52-56
23755240-3	2013	Here we report the expression of hCCR3 gene in a tetracycline-inducible stable mammalian cell line.	tet	49-61	C-C motif chemokine receptor 3	Homo sapiens	33-38
23762468-2	2013	We studied in real time the delivery of YFP-prestin to the plasma membrane of cells from a tetracycline-inducible cell line.	tet	91-103	solute carrier family 26 member 5	Homo sapiens	44-51
22319007-2	2013	A stable mammalian cell line, CHO-K1 Tet-IGFI, was genetically modified to have tetracycline-induced transcription of the human IGF-I gene.	tet	80-92	insulin like growth factor 1	Homo sapiens	128-133
22319007-3	2013	Cells were activated to express IGF-I in the presence of doxycycline (DOX), a tetracycline derivative, while expression was inactivated in the absence of DOX.	tet	78-90	insulin like growth factor 1	Homo sapiens	32-37
23415753-6	2013	Overexpression of VGLL3 in OV-90 was achieved using a lentivirus-based tetracycline inducible gene expression system, which also resulted in MVB formation in the infected cell population.	tet	71-83	vestigial like family member 3	Mus musculus	18-23
23730214-3	2013	Furthermore, using epithelial cell lines expressing CD74 under the control of tetracycline-inducible promoter and quantitative high-resolution mass spectrometry, we demonstrate that, as a result of CD74 overexpression, the phosphorylation pattern of the C-terminal part of Scribble undergoes specific changes.	tet	78-90	CD74 molecule	Homo sapiens	198-202
23397077-2	2013	Furthermore, recent advanced systems allow controlled expression of the effector RNA via coexpression of a tetracycline/doxycycline (DOX) responsive repressor (tTR-KRAB).	tet	107-119	transthyretin	Homo sapiens	160-163
23703389-5	2013	In this study, we established cell lines in which NLRP3 was induced by doxycycline using a tetracycline-inducible expression (Tet-on) system.	tet	91-103	NLR family pyrin domain containing 3	Homo sapiens	50-55
23754979-6	2013	We addressed this issue using a neuronal cell model which inducibly expresses human wild-type alpha-syn by the tetracycline off (Tet-Off) mechanism and stably expresses high levels of DA transporter.	tet	111-123	synuclein alpha	Homo sapiens	94-103
23696845-1	2013	Nowadays, baculovirus-infected insect cells and tetracycline-inducible mammalian cell lines (T-REx-293) are intensively used for G protein-coupled receptor (GPCR) production for crystallography purposes.	tet	48-60	C-X-C motif chemokine receptor 6	Homo sapiens	129-155
23696845-1	2013	Nowadays, baculovirus-infected insect cells and tetracycline-inducible mammalian cell lines (T-REx-293) are intensively used for G protein-coupled receptor (GPCR) production for crystallography purposes.	tet	48-60	C-X-C motif chemokine receptor 6	Homo sapiens	157-161
23376423-6	2013	Expression of Spdef also was induced transiently by administration of tetracycline to Spdef(dox-intestine) mice with established tumors, induced by the combination of AOM and DSS or by breeding with Apc(Min/+) mice.	tet	70-82	SAM pointed domain containing ets transcription factor	Mus musculus	14-19
23376423-6	2013	Expression of Spdef also was induced transiently by administration of tetracycline to Spdef(dox-intestine) mice with established tumors, induced by the combination of AOM and DSS or by breeding with Apc(Min/+) mice.	tet	70-82	SAM pointed domain containing ets transcription factor	Mus musculus	86-91
23856869-6	2013	The specimens had plasmid-mediated resistance to penicillin PPNG 14.5% (29/201) and tetracycline TRNG 11.5% (23/201).	tet	84-96	mitochondrially encoded tRNA glycine	Homo sapiens	97-101
23688984-2	2013	METHODS: The total RNA were extracted from tetracycline-inducible SNF5 knockdown (KD) cell line derived from KM3 cells for gene expression profiling by affymetrix microarray and bioinformatic analysis.	tet	43-55	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	66-70
23719597-5	2013	The functions of Cdkn1a were analyzed using two approaches, treatment of primary rat PSC with siRNA and tetracycline-regulated overexpression of Cdkn1a in immortalized rat cells.	tet	104-116	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	17-23
23719597-5	2013	The functions of Cdkn1a were analyzed using two approaches, treatment of primary rat PSC with siRNA and tetracycline-regulated overexpression of Cdkn1a in immortalized rat cells.	tet	104-116	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	145-151
23658710-3	2013	Here we show that tetracycline inducible depletion of Kif3a in MDCK cells slows epithelial cell migration.	tet	18-30	kinesin family member 3A	Homo sapiens	54-59
22799755-12	2013	It is important and clinically relevant to determine whether tetracycline and its other derivatives also counteract BMP functions.	tet	61-73	bone morphogenetic protein 1	Homo sapiens	116-119
23439385-14	2013	Both PARP-1 inhibitors: 3-aminobenzamide (3-AB) and PJ 34, tetracycline: doxocycline and minocycline, as well as DHA protected the cells against PAR formation and AIF translocation.	tet	59-71	poly(ADP-ribose) polymerase 1	Homo sapiens	5-11
23422647-4	2013	Here we established a Huh7.5-BST2-TO cell line, in which BST2 expression is regulated by tetracycline.	tet	89-101	bone marrow stromal cell antigen 2	Homo sapiens	29-33
23422647-4	2013	Here we established a Huh7.5-BST2-TO cell line, in which BST2 expression is regulated by tetracycline.	tet	89-101	bone marrow stromal cell antigen 2	Homo sapiens	57-61
23271055-4	2013	When overexpressed in a tetracycline (Tet)-based protein chase model, constitutive heat shock cognate 70 (Hsc70) and inducible Hsp72 slowed or accelerated tau clearance, respectively.	tet	24-36	heat shock protein family A (Hsp70) member 8	Homo sapiens	83-104
23271055-4	2013	When overexpressed in a tetracycline (Tet)-based protein chase model, constitutive heat shock cognate 70 (Hsc70) and inducible Hsp72 slowed or accelerated tau clearance, respectively.	tet	24-36	heat shock protein family A (Hsp70) member 8	Homo sapiens	106-111
23271055-4	2013	When overexpressed in a tetracycline (Tet)-based protein chase model, constitutive heat shock cognate 70 (Hsc70) and inducible Hsp72 slowed or accelerated tau clearance, respectively.	tet	24-36	heat shock protein family A (Hsp70) member 1A	Homo sapiens	127-132
23271055-4	2013	When overexpressed in a tetracycline (Tet)-based protein chase model, constitutive heat shock cognate 70 (Hsc70) and inducible Hsp72 slowed or accelerated tau clearance, respectively.	tet	38-41	heat shock protein family A (Hsp70) member 8	Homo sapiens	83-104
23271055-4	2013	When overexpressed in a tetracycline (Tet)-based protein chase model, constitutive heat shock cognate 70 (Hsc70) and inducible Hsp72 slowed or accelerated tau clearance, respectively.	tet	38-41	heat shock protein family A (Hsp70) member 8	Homo sapiens	106-111
23271055-4	2013	When overexpressed in a tetracycline (Tet)-based protein chase model, constitutive heat shock cognate 70 (Hsc70) and inducible Hsp72 slowed or accelerated tau clearance, respectively.	tet	38-41	heat shock protein family A (Hsp70) member 1A	Homo sapiens	127-132
23271055-4	2013	When overexpressed in a tetracycline (Tet)-based protein chase model, constitutive heat shock cognate 70 (Hsc70) and inducible Hsp72 slowed or accelerated tau clearance, respectively.	tet	38-41	microtubule associated protein tau	Homo sapiens	155-158
23626683-0	2013	Construction of a single lentiviral vector containing tetracycline-inducible Alb-uPA for transduction of uPA expression in murine hepatocytes.	tet	54-66	albumin	Mus musculus	77-80
23626683-0	2013	Construction of a single lentiviral vector containing tetracycline-inducible Alb-uPA for transduction of uPA expression in murine hepatocytes.	tet	54-66	proline-rich acidic protein 1	Mus musculus	81-84
23626683-0	2013	Construction of a single lentiviral vector containing tetracycline-inducible Alb-uPA for transduction of uPA expression in murine hepatocytes.	tet	54-66	proline-rich acidic protein 1	Mus musculus	105-108
23626683-4	2013	In order to optimize the procedure, we constructed a single lentiviral vector containing modified tetracycline-regulated system to control Alb-uPA gene expression in the cultured hepatocytes.	tet	98-110	albumin	Mus musculus	139-142
23626683-4	2013	In order to optimize the procedure, we constructed a single lentiviral vector containing modified tetracycline-regulated system to control Alb-uPA gene expression in the cultured hepatocytes.	tet	98-110	proline-rich acidic protein 1	Mus musculus	143-146
23626683-6	2013	The full-length uPA cDNA was inserted into another lentiviral vector containing PTight, a modified Tet-responsive promoter.	tet	99-102	proline-rich acidic protein 1	Mus musculus	16-19
23384425-2	2013	Tetracycline-induced, Pax8-rtTA-based knockout of VHL (VHL-KO) affects all renal tubules and periportal hepatocytes and leads to sustained upregulation of HIF.	tet	0-12	paired box 8	Mus musculus	22-26
23291318-5	2013	Using tetracycline inducible cells we demonstrated a repressive effect of WT1 on USP18 expression.	tet	6-18	WT1 transcription factor	Mus musculus	74-77
23291318-5	2013	Using tetracycline inducible cells we demonstrated a repressive effect of WT1 on USP18 expression.	tet	6-18	ubiquitin specific peptidase 18	Mus musculus	81-86
23384425-2	2013	Tetracycline-induced, Pax8-rtTA-based knockout of VHL (VHL-KO) affects all renal tubules and periportal hepatocytes and leads to sustained upregulation of HIF.	tet	0-12	von Hippel-Lindau tumor suppressor	Mus musculus	50-53
23384425-2	2013	Tetracycline-induced, Pax8-rtTA-based knockout of VHL (VHL-KO) affects all renal tubules and periportal hepatocytes and leads to sustained upregulation of HIF.	tet	0-12	von Hippel-Lindau tumor suppressor	Mus musculus	55-61
23288842-4	2013	Human TRPV4 was expressed in HEK293 cells under control of a tetracycline-inducible promoter, allowing controlled and graded channel expression.	tet	61-73	transient receptor potential cation channel subfamily V member 4	Homo sapiens	6-11
22860629-2	2013	The current study examines the role of PrP(C)  in early human embryogenesis using human embryonic stem cells (hESCs) and tetracycline-regulated lentiviral vectors that up-regulate or suppresses PrP(C)  expression.	tet	121-133	prion protein	Homo sapiens	194-200
22469981-3	2013	A tetracycline-inducible transgenic mouse model expressing truncated beta-catenin (DeltaN89beta-catenin) that exhibited a strong intestinal hyperplasia was analyzed during the removal of oncogenic beta-catenin expression both in 3D "crypt culture" and in vivo.	tet	2-14	catenin (cadherin associated protein), beta 1	Mus musculus	69-81
22469981-3	2013	A tetracycline-inducible transgenic mouse model expressing truncated beta-catenin (DeltaN89beta-catenin) that exhibited a strong intestinal hyperplasia was analyzed during the removal of oncogenic beta-catenin expression both in 3D "crypt culture" and in vivo.	tet	2-14	catenin (cadherin associated protein), beta 1	Mus musculus	91-103
23374512-10	2013	RESULTS: The vancomycin-resistant isolate CP2 was found to be resistant to oxacillin, chloramphenicol, erythromycin, rifampicin, gentamicin, tetracycline and ciprofloxacin, as well.	tet	141-153	ceruloplasmin	Homo sapiens	42-45
23243017-2	2013	Tetracycline-inducible Bcl-2 and Bcl-xL dual knockdown sharply increased PI3K/AKT/mTOR inhibitor lethality.	tet	0-12	BCL2 apoptosis regulator	Homo sapiens	23-28
23243017-2	2013	Tetracycline-inducible Bcl-2 and Bcl-xL dual knockdown sharply increased PI3K/AKT/mTOR inhibitor lethality.	tet	0-12	BCL2 like 1	Homo sapiens	33-39
23243017-2	2013	Tetracycline-inducible Bcl-2 and Bcl-xL dual knockdown sharply increased PI3K/AKT/mTOR inhibitor lethality.	tet	0-12	AKT serine/threonine kinase 1	Homo sapiens	78-81
23243017-2	2013	Tetracycline-inducible Bcl-2 and Bcl-xL dual knockdown sharply increased PI3K/AKT/mTOR inhibitor lethality.	tet	0-12	mechanistic target of rapamycin kinase	Homo sapiens	82-86
23243017-11	2013	In a systemic AML xenograft model, dual tetracycline-inducible knockdown of Bcl-2/Bcl-xL sharply increased BEZ235 antileukemic effects.	tet	40-52	BCL2 apoptosis regulator	Homo sapiens	76-81
23243017-11	2013	In a systemic AML xenograft model, dual tetracycline-inducible knockdown of Bcl-2/Bcl-xL sharply increased BEZ235 antileukemic effects.	tet	40-52	BCL2 like 1	Homo sapiens	82-88
23348737-3	2013	To determine the role of renal tubular NEDD4-2 in adult mice, we generated tetracycline-inducible, nephron-specific Nedd4L KO mice.	tet	75-87	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	116-122
23002099-0	2013	Intrapleural adenoviral delivery of human plasminogen activator inhibitor-1 exacerbates tetracycline-induced pleural injury in rabbits.	tet	88-100	serpin family E member 1	Homo sapiens	42-75
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	8-11	CD4 antigen	Mus musculus	22-25
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	8-11	CD4 antigen	Mus musculus	55-58
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	8-11	CD4 antigen	Mus musculus	55-58
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	8-11	CD4 antigen	Mus musculus	55-58
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	8-11	CD4 antigen	Mus musculus	55-58
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	8-11	CD4 antigen	Mus musculus	55-58
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	85-88	CD4 antigen	Mus musculus	22-25
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	85-88	CD4 antigen	Mus musculus	55-58
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	85-88	CD4 antigen	Mus musculus	55-58
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	85-88	CD4 antigen	Mus musculus	55-58
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	85-88	CD4 antigen	Mus musculus	55-58
23293358-5	2013	Using a tet-sensitive Cd4 allele harboring a removable Cd4 silencer, we found that a tet-controlled repressor recapitulated the phenotype of Cd4-deficient mice, inhibited Cd4 expression in a reversible and dose-dependent manner, and could surprisingly replace the Cd4 silencer to induce irreversible Cd4 silencing in CD8 cells, thus suggesting the Cd4 silencer is not the (only) determinant of heterochromatin formation.	tet	85-88	CD4 antigen	Mus musculus	55-58
23293358-6	2013	In contrast, a tet-controlled activator reversibly disrupted Cd4 silencing in CD8 cells.	tet	15-18	CD4 antigen	Mus musculus	61-64
23002099-7	2013	The adenovirus-mediated delivery of hPAI-1 with subsequent tetracycline-induced pleural injury resulted in a significant exacerbation of the pleural fibrosis observed on Day 5 (P = 0.029 and P = 0.021 versus vehicle and adenoviral control samples, respectively).	tet	59-71	serpin family E member 1	Homo sapiens	36-42
23873371-5	2013	Immunohistological studies were performed in a mouse model in which expression of Pdx1 was conditionally repressed with the doxycycline-responsive tetracycline transactivator system.	tet	147-159	pancreatic and duodenal homeobox 1	Mus musculus	82-86
24074261-5	2013	METHODS: We developed a tetracycline-regulatable Cdc42 overexpression mouse model in which Cdc42 can be inducibly overexpressed in the developing mammary gland.	tet	24-36	cell division cycle 42	Mus musculus	49-54
24074261-5	2013	METHODS: We developed a tetracycline-regulatable Cdc42 overexpression mouse model in which Cdc42 can be inducibly overexpressed in the developing mammary gland.	tet	24-36	cell division cycle 42	Mus musculus	91-96
24006068-0	2013	Generation of a tetracycline regulated mouse model of MYC-induced T-cell acute lymphoblastic leukemia.	tet	16-28	myelocytomatosis oncogene	Mus musculus	54-57
23164231-6	2013	Bone histomorphometry showed that new bone formation (assessed using tetracycline-HCl labels) tended to be stronger with apo-LF than with holo-LF.	tet	69-85	lactotransferrin	Mus musculus	125-127
23719921-5	2013	We have developed a stably transfected, tetracycline-inducible, cell model that replicates many of the hallmarks of disease, including ligand-dependent aggregation and toxicity, and provides a relatively quick system for the reliable expression and analysis of the mutated polyglutamine-expanded AR.	tet	40-52	androgen receptor	Homo sapiens	296-298
23077293-7	2013	We confirmed this IRF-3 threshold idea by generating a tetracycline (Tet)-inducible cell line for IRF-3 expression, which enabled us to express various levels of IRF-3.	tet	55-67	interferon regulatory factor 3	Homo sapiens	18-23
23077293-7	2013	We confirmed this IRF-3 threshold idea by generating a tetracycline (Tet)-inducible cell line for IRF-3 expression, which enabled us to express various levels of IRF-3.	tet	55-67	interferon regulatory factor 3	Homo sapiens	98-103
23077293-7	2013	We confirmed this IRF-3 threshold idea by generating a tetracycline (Tet)-inducible cell line for IRF-3 expression, which enabled us to express various levels of IRF-3.	tet	55-67	interferon regulatory factor 3	Homo sapiens	98-103
23077293-7	2013	We confirmed this IRF-3 threshold idea by generating a tetracycline (Tet)-inducible cell line for IRF-3 expression, which enabled us to express various levels of IRF-3.	tet	69-72	interferon regulatory factor 3	Homo sapiens	18-23
23077293-7	2013	We confirmed this IRF-3 threshold idea by generating a tetracycline (Tet)-inducible cell line for IRF-3 expression, which enabled us to express various levels of IRF-3.	tet	69-72	interferon regulatory factor 3	Homo sapiens	98-103
23077293-7	2013	We confirmed this IRF-3 threshold idea by generating a tetracycline (Tet)-inducible cell line for IRF-3 expression, which enabled us to express various levels of IRF-3.	tet	69-72	interferon regulatory factor 3	Homo sapiens	98-103
23403578-1	2013	Tetracycline resistance protein Tet(O), which protects the bacterial ribosome from binding the antibiotic tetracycline, is a translational GTPase with significant similarity in both sequence and structure to the elongation factor EF-G.	tet	0-12	G elongation factor mitochondrial 1	Homo sapiens	230-234
23403578-1	2013	Tetracycline resistance protein Tet(O), which protects the bacterial ribosome from binding the antibiotic tetracycline, is a translational GTPase with significant similarity in both sequence and structure to the elongation factor EF-G.	tet	106-118	G elongation factor mitochondrial 1	Homo sapiens	230-234
23691430-2	2013	The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA).	tet	4-16	chromosome 20 open reading frame 181	Homo sapiens	124-152
23269553-4	2013	A modified tetracycline operator 7 (tetO7) was inserted into a region upstream of the EF1-alpha promoter to drive GDNF expression.	tet	11-23	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	86-95
23269553-4	2013	A modified tetracycline operator 7 (tetO7) was inserted into a region upstream of the EF1-alpha promoter to drive GDNF expression.	tet	11-23	glial cell derived neurotrophic factor	Homo sapiens	114-118
22722256-0	2013	Inhibition of pancreatic cancer cell growth in vivo using a tetracycline-inducible cyclin D1 antisense expression system.	tet	60-72	cyclin D1	Homo sapiens	83-92
22722256-5	2013	RESULTS: In vitro removal of tetracycline induced cyclin D1 antisense cDNA expression and inhibited cyclin D1 expression and cyclin D1-associated kinase activity as well as anchorage-dependent and -independent growth.	tet	29-41	cyclin D1	Homo sapiens	50-59
22722256-5	2013	RESULTS: In vitro removal of tetracycline induced cyclin D1 antisense cDNA expression and inhibited cyclin D1 expression and cyclin D1-associated kinase activity as well as anchorage-dependent and -independent growth.	tet	29-41	cyclin D1	Homo sapiens	100-109
22722256-5	2013	RESULTS: In vitro removal of tetracycline induced cyclin D1 antisense cDNA expression and inhibited cyclin D1 expression and cyclin D1-associated kinase activity as well as anchorage-dependent and -independent growth.	tet	29-41	cyclin D1	Homo sapiens	100-109
23469077-3	2013	In the present study we found that administration of chemically modified tetracycline-3 (COL-3), inhibits lipopolysaccharide (LPS)-induced microglial and p38 MAPK activation, as well as the increase in TNF-alpha, but not IL-1beta expression, in the brains of BALB/c mice.	tet	73-85	mitogen-activated protein kinase 14	Mus musculus	154-157
23469077-3	2013	In the present study we found that administration of chemically modified tetracycline-3 (COL-3), inhibits lipopolysaccharide (LPS)-induced microglial and p38 MAPK activation, as well as the increase in TNF-alpha, but not IL-1beta expression, in the brains of BALB/c mice.	tet	73-85	tumor necrosis factor	Mus musculus	202-211
23469077-3	2013	In the present study we found that administration of chemically modified tetracycline-3 (COL-3), inhibits lipopolysaccharide (LPS)-induced microglial and p38 MAPK activation, as well as the increase in TNF-alpha, but not IL-1beta expression, in the brains of BALB/c mice.	tet	73-85	interleukin 1 beta	Mus musculus	221-229
23691430-2	2013	The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA).	tet	4-16	chromosome 20 open reading frame 181	Homo sapiens	154-157
23131502-0	2012	Selective degradation of tetracycline antibiotics present in raw milk by electrochemical method.	tet	25-37	Weaning weight-maternal milk	Bos taurus	65-69
22945289-4	2012	To elucidate the function of ZNF385B in healthy B cells, we established a tetracycline-controlled protein-inducible system in B-cell lines and observed that ectopic expression of the longest transcript variant of ZNF385B, possessing four ZF domains, induced upregulation of PERP and FAS/CD95, a downstream target of p53, and activation of caspase, resulting in apoptosis induction.	tet	74-86	zinc finger protein 385B	Homo sapiens	29-36
22945289-4	2012	To elucidate the function of ZNF385B in healthy B cells, we established a tetracycline-controlled protein-inducible system in B-cell lines and observed that ectopic expression of the longest transcript variant of ZNF385B, possessing four ZF domains, induced upregulation of PERP and FAS/CD95, a downstream target of p53, and activation of caspase, resulting in apoptosis induction.	tet	74-86	zinc finger protein 385B	Homo sapiens	213-220
23027468-11	2012	Tetracycline had minimum effect on the expression of MMP-9 and tumor necrosis factor-alpha (TNF-alpha) but it decreased gene activation and inhibited the expression of RANK and RANKL, thereby inhibiting Ti-particle-induced inflammatory osteolysis.	tet	0-12	matrix metallopeptidase 9	Mus musculus	53-58
23027468-11	2012	Tetracycline had minimum effect on the expression of MMP-9 and tumor necrosis factor-alpha (TNF-alpha) but it decreased gene activation and inhibited the expression of RANK and RANKL, thereby inhibiting Ti-particle-induced inflammatory osteolysis.	tet	0-12	tumor necrosis factor	Mus musculus	63-90
23027468-11	2012	Tetracycline had minimum effect on the expression of MMP-9 and tumor necrosis factor-alpha (TNF-alpha) but it decreased gene activation and inhibited the expression of RANK and RANKL, thereby inhibiting Ti-particle-induced inflammatory osteolysis.	tet	0-12	tumor necrosis factor	Mus musculus	92-101
23027468-11	2012	Tetracycline had minimum effect on the expression of MMP-9 and tumor necrosis factor-alpha (TNF-alpha) but it decreased gene activation and inhibited the expression of RANK and RANKL, thereby inhibiting Ti-particle-induced inflammatory osteolysis.	tet	0-12	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	177-182
23027468-12	2012	Tetracycline decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive cells in the pouch tissues.	tet	0-12	acid phosphatase 5, tartrate resistant	Mus musculus	37-72
23027468-12	2012	Tetracycline decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive cells in the pouch tissues.	tet	0-12	acid phosphatase 5, tartrate resistant	Mus musculus	74-78
23027468-13	2012	Our results in the murine osteolysis model suggest that through the downregulation of RANK/RANKL, tetracycline significantly inhibits debris-induced inflammatory osteolysis.	tet	98-110	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	91-96
23023870-7	2012	Overexpression of wild-type mouse Shh through the tetracycline-regulated expression-inducible system in human aortic SMCs time-dependently increased the levels of LC3-II and also stimulated protein kinase B (AKT) phosphorylation.	tet	50-62	sonic hedgehog	Mus musculus	34-37
23023870-7	2012	Overexpression of wild-type mouse Shh through the tetracycline-regulated expression-inducible system in human aortic SMCs time-dependently increased the levels of LC3-II and also stimulated protein kinase B (AKT) phosphorylation.	tet	50-62	AKT serine/threonine kinase 1	Homo sapiens	208-211
22743615-4	2012	Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity.	tet	8-20	latent transforming growth factor beta binding protein 2	Homo sapiens	92-98
22743615-4	2012	Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity.	tet	8-20	vascular endothelial growth factor A	Homo sapiens	192-196
22935140-2	2012	We were interested in the consequence of blunting this pathway by employing transgenic mice with tetracycline-controllable conditional expression of a constitutively active allele of FOXO3 under the control of the forebrain-specific CaMKIIalpha promoter.	tet	97-109	forkhead box O3	Mus musculus	183-188
22749725-6	2012	Compared with non-hVISA MRSA, hVISA isolates had higher resistant rates to ciprofloxacin, gentamicin, trimethoprim/sulfamethoxazole, and tetracycline.	tet	137-149	mitochondrial antiviral signaling protein	Homo sapiens	30-35
22846623-2	2012	Binding of the antibiotic drugs tetracycline and rolitetracycline with serum albumin has been studied by a combination of isothermal titration calorimetry, differential scanning calorimetry, steady-state and time-resolved fluorescence, and circular dichroism spectroscopies.	tet	32-44	albumin	Homo sapiens	71-84
22901507-0	2012	Use of engineered bone marrow stem cells to deliver brain derived neurotrophic factor under the control of a tetracycline sensitive response element in experimental allergic encephalomyelitis.	tet	109-121	brain derived neurotrophic factor	Homo sapiens	52-85
22901507-3	2012	We have refined the BMSC based delivery system by introducing a tetracycline sensitive response element to control BDNF expression.	tet	64-76	brain derived neurotrophic factor	Homo sapiens	115-119
23134703-5	2012	It carried a spa type t011-SCCmecV isolate, resistant to beta-lactams and tetracycline, which is typical for livestock-associated MRSA CC398.	tet	74-86	pulmonary surfactant-associated protein A	Equus caballus	13-16
23002205-1	2012	We identified Bub1b as an essential element for the growth and survival of rhabdomyosarcoma (RMS) cells using a bar-coded, tetracycline-inducible short hairpin RNA (shRNA) library screen.	tet	123-135	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	14-19
22646516-4	2012	EXPERIMENTAL APPROACH: Human TRPM2 channels in tetracycline-regulated pcDNA4/TO vectors were transfected into HEK293 T-REx cells and the expression was induced by tetracycline.	tet	47-59	transient receptor potential cation channel subfamily M member 2	Homo sapiens	29-34
22646516-4	2012	EXPERIMENTAL APPROACH: Human TRPM2 channels in tetracycline-regulated pcDNA4/TO vectors were transfected into HEK293 T-REx cells and the expression was induced by tetracycline.	tet	163-175	transient receptor potential cation channel subfamily M member 2	Homo sapiens	29-34
22846623-0	2012	Unraveling the energetics and mode of the recognition of antibiotics tetracycline and rolitetracycline by bovine serum albumin.	tet	69-81	albumin	Homo sapiens	113-126
22846623-3	2012	Both tetracycline and rolitetracycline bind to bovine serum albumin in a sequential manner with first binding being the major binding event with an association constant of the order of 10(4) for tetracycline and 10(3) for rolitetracycline, respectively.	tet	5-17	albumin	Homo sapiens	54-67
22846623-3	2012	Both tetracycline and rolitetracycline bind to bovine serum albumin in a sequential manner with first binding being the major binding event with an association constant of the order of 10(4) for tetracycline and 10(3) for rolitetracycline, respectively.	tet	26-38	albumin	Homo sapiens	54-67
22865650-5	2012	METHODS: Overexpression of ZAC was achieved through the tetracycline-regulatable system in the beta-cell line, INS-1.	tet	56-68	PLAG1 like zinc finger 1	Homo sapiens	27-30
22878555-3	2012	Previously, it has been reported that a transposon insertion mutant in gene PA2800 of P. aeruginosa PAO1 was more sensitive to tetracycline and ciprofloxacin.	tet	127-139	hypothetical protein	Pseudomonas aeruginosa PAO1	76-82
22924521-11	2012	Moreover, complete tetracycline resistance genes tet(A) and tet(R) were found upstream of the qnrS1 gene, and floR gene was found downstream of the qnrS1 gene on the plasmid pT078.	tet	19-31	QnrS1	Escherichia coli	94-99
22992951-5	2012	Furthermore, a subpopulation of Sox1-marked cells have long-term neurogenic potential, producing new neurons 3 months after inactivation of tetracycline transactivator.	tet	140-152	SRY (sex determining region Y)-box 1	Mus musculus	32-36
23110550-8	2012	EpCAMlow cell lines with tetracycline-inducible overexpression of EpCAM showed no increased cell proliferation or migration under serum-reduced growth conditions.	tet	25-37	epithelial cell adhesion molecule	Homo sapiens	0-5
22924521-11	2012	Moreover, complete tetracycline resistance genes tet(A) and tet(R) were found upstream of the qnrS1 gene, and floR gene was found downstream of the qnrS1 gene on the plasmid pT078.	tet	19-31	QnrS1	Escherichia coli	148-153
23028353-5	2012	A single auto-regulatory tetracycline-sensitive expression cassette controlled expression of transgenic Hexb in the brain of Hexb-/- mice and provided long-term rescue from the acute neuronopathic disorder, as well as the accompanying pathological storage of glycoconjugates and gliosis in most parts of the brain.	tet	25-37	hexosaminidase B	Mus musculus	104-108
22906311-7	2012	Among the 295 E. coli, the highest antibiotic resistance level was observed against tetracycline and beta-lactams associated mainly with the resistance genes tetB and bla(CMY-2), respectively.	tet	84-96	beta-lactamase	Escherichia coli	167-170
22713118-2	2012	The mutant strain tetMSI3 was generated, in which MSI3 was controlled by a tetracycline-repressive promoter, because there is evidence to suggest that MSI3 is an essential gene.	tet	75-87	adenyl-nucleotide exchange factor SSE1	Saccharomyces cerevisiae S288C	50-54
22993437-3	2012	Using tetracycline-regulated (tet-off) lentiviral gene delivery, NT-3 expression was tightly controlled by doxycycline administration.	tet	6-18	neurotrophin 3	Rattus norvegicus	65-69
22910411-3	2012	Using HepG2 cells expressing human CAR in the presence of tetracycline, we showed that knockdown of DP97 with small interfering RNAs suppressed tetracycline-inducible mRNA expression of CYP2B6 and UGT1A1 but not CYP3A4.	tet	58-70	nuclear receptor subfamily 1 group I member 3	Homo sapiens	35-38
22910411-3	2012	Using HepG2 cells expressing human CAR in the presence of tetracycline, we showed that knockdown of DP97 with small interfering RNAs suppressed tetracycline-inducible mRNA expression of CYP2B6 and UGT1A1 but not CYP3A4.	tet	58-70	DEAD-box helicase 54	Homo sapiens	100-104
22910411-3	2012	Using HepG2 cells expressing human CAR in the presence of tetracycline, we showed that knockdown of DP97 with small interfering RNAs suppressed tetracycline-inducible mRNA expression of CYP2B6 and UGT1A1 but not CYP3A4.	tet	144-156	nuclear receptor subfamily 1 group I member 3	Homo sapiens	35-38
22910411-3	2012	Using HepG2 cells expressing human CAR in the presence of tetracycline, we showed that knockdown of DP97 with small interfering RNAs suppressed tetracycline-inducible mRNA expression of CYP2B6 and UGT1A1 but not CYP3A4.	tet	144-156	DEAD-box helicase 54	Homo sapiens	100-104
22910411-3	2012	Using HepG2 cells expressing human CAR in the presence of tetracycline, we showed that knockdown of DP97 with small interfering RNAs suppressed tetracycline-inducible mRNA expression of CYP2B6 and UGT1A1 but not CYP3A4.	tet	144-156	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	186-192
22910411-3	2012	Using HepG2 cells expressing human CAR in the presence of tetracycline, we showed that knockdown of DP97 with small interfering RNAs suppressed tetracycline-inducible mRNA expression of CYP2B6 and UGT1A1 but not CYP3A4.	tet	144-156	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	197-203
22910411-3	2012	Using HepG2 cells expressing human CAR in the presence of tetracycline, we showed that knockdown of DP97 with small interfering RNAs suppressed tetracycline-inducible mRNA expression of CYP2B6 and UGT1A1 but not CYP3A4.	tet	144-156	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	212-218
22964287-12	2012	A significant association of ESBL expression in E. coli was observed with resistance to tobramycin (p&lt;=0.001), tetracycline (p=0.043), and ciprofloxacin (p&lt;=0.001).	tet	114-126	EsbL	Escherichia coli	29-33
22407857-3	2012	To activate the NF-kappaB signaling pathway in a time- and cell-type-specific manner in the liver, we crossed transgenic mice carrying the tetracycline-responsive transactivator under the control of the liver activator protein promotor with transgenic mice carrying a constitutively active form of the Ikbkb gene (IKK2 protein [CAIKK2]).	tet	139-151	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	16-25
22407857-3	2012	To activate the NF-kappaB signaling pathway in a time- and cell-type-specific manner in the liver, we crossed transgenic mice carrying the tetracycline-responsive transactivator under the control of the liver activator protein promotor with transgenic mice carrying a constitutively active form of the Ikbkb gene (IKK2 protein [CAIKK2]).	tet	139-151	inhibitor of kappaB kinase beta	Mus musculus	302-307
22407857-3	2012	To activate the NF-kappaB signaling pathway in a time- and cell-type-specific manner in the liver, we crossed transgenic mice carrying the tetracycline-responsive transactivator under the control of the liver activator protein promotor with transgenic mice carrying a constitutively active form of the Ikbkb gene (IKK2 protein [CAIKK2]).	tet	139-151	inhibitor of kappaB kinase beta	Mus musculus	314-318
23028353-5	2012	A single auto-regulatory tetracycline-sensitive expression cassette controlled expression of transgenic Hexb in the brain of Hexb-/- mice and provided long-term rescue from the acute neuronopathic disorder, as well as the accompanying pathological storage of glycoconjugates and gliosis in most parts of the brain.	tet	25-37	hexosaminidase B	Mus musculus	125-129
22635920-3	2012	By use of a strain whose only copy of HSP104 is an ectopic gene under the control of a tetracycline-regulated promoter, expression of Hsp104 prior to the administration of heat shock could be demonstrated to be sufficient to confer protection from the subsequent temperature increase.	tet	87-99	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	38-44
22786907-1	2012	PURPOSE: The Tet-mev-1 mouse expressing a mitochondrial complex-II mutated SDHC(V69E) gene controlled by a tetracycline (Tet)-On/Off system can overproduce O(2)( -) and is a versatile whole-animal model for studying mitochondrial oxidative stress.	tet	13-16	succinate dehydrogenase complex, subunit C, integral membrane protein	Mus musculus	75-79
22786907-1	2012	PURPOSE: The Tet-mev-1 mouse expressing a mitochondrial complex-II mutated SDHC(V69E) gene controlled by a tetracycline (Tet)-On/Off system can overproduce O(2)( -) and is a versatile whole-animal model for studying mitochondrial oxidative stress.	tet	107-119	succinate dehydrogenase complex, subunit C, integral membrane protein	Mus musculus	75-79
22786907-1	2012	PURPOSE: The Tet-mev-1 mouse expressing a mitochondrial complex-II mutated SDHC(V69E) gene controlled by a tetracycline (Tet)-On/Off system can overproduce O(2)( -) and is a versatile whole-animal model for studying mitochondrial oxidative stress.	tet	121-124	succinate dehydrogenase complex, subunit C, integral membrane protein	Mus musculus	75-79
22635920-3	2012	By use of a strain whose only copy of HSP104 is an ectopic gene under the control of a tetracycline-regulated promoter, expression of Hsp104 prior to the administration of heat shock could be demonstrated to be sufficient to confer protection from the subsequent temperature increase.	tet	87-99	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	134-140
21586598-3	2012	The aim of this study was to develop biodegradable, tetracycline-loaded microparticles made of two polymers: PLGA and zein which were compressed into monolithic devices.	tet	52-64	zein	Zea mays	118-122
22367974-5	2012	To circumvent these confounds, we developed transgenic mice that express tetracycline transactivator regulated, dominant negative transferrin receptor (DNTfR1) in hippocampal neurons, disrupting TfR1 mediated iron uptake specifically in CA1 pyramidal neurons.	tet	73-85	transferrin receptor	Mus musculus	130-150
22367974-5	2012	To circumvent these confounds, we developed transgenic mice that express tetracycline transactivator regulated, dominant negative transferrin receptor (DNTfR1) in hippocampal neurons, disrupting TfR1 mediated iron uptake specifically in CA1 pyramidal neurons.	tet	73-85	transferrin receptor	Mus musculus	154-158
22367974-5	2012	To circumvent these confounds, we developed transgenic mice that express tetracycline transactivator regulated, dominant negative transferrin receptor (DNTfR1) in hippocampal neurons, disrupting TfR1 mediated iron uptake specifically in CA1 pyramidal neurons.	tet	73-85	carbonic anhydrase 1	Mus musculus	237-240
21586598-5	2012	The interaction of tetracycline with the corn protein zein was studied by nuclear magnetic resonance (NMR), Fourier transform infrared, and X-ray diffraction.	tet	19-31	zein	Zea mays	54-58
21586598-6	2012	The hydrophobic interaction of tetracycline with zein in the formulations was deduced from the NMR studies, whereas X-ray diffraction studies showed a new crystalline state of the drug in the presence of the protein.	tet	31-43	zein	Zea mays	49-53
21586598-8	2012	Sustained release of tetracycline was obtained, and the proportion of zein in the inserts had a great impact on the drug release.	tet	21-33	zein	Zea mays	70-74
21586598-10	2012	In conclusion, the PLGA:zein delivery system described in this study was found to be effective in controlled delivery of tetracycline, and hence may be suitable for intra-pocket delivery of antimicrobial agents in the treatment of periodontitis.	tet	121-133	zein	Zea mays	24-28
22002309-2	2012	To investigate whether nuclear factor (NF)-kappaB, a key mediator of immune and inflammatory responses, provides an interface between persistent lung inflammation and carcinogenesis, we utilized tetracycline-inducible transgenic mice expressing constitutively active IkappaB kinase beta in airway epithelium (IKTA (IKKbeta trans-activated) mice).	tet	195-207	inhibitor of kappaB kinase beta	Mus musculus	267-286
22764233-3	2012	To gain mechanistic insights into the alpha-syn-induced mDA neurodegeneration, we generated a new line of tetracycline-regulated inducible transgenic mice that overexpressed the PD-related alpha-syn A53T missense mutation in the mDA neurons.	tet	106-118	synuclein, alpha	Mus musculus	38-47
22764233-3	2012	To gain mechanistic insights into the alpha-syn-induced mDA neurodegeneration, we generated a new line of tetracycline-regulated inducible transgenic mice that overexpressed the PD-related alpha-syn A53T missense mutation in the mDA neurons.	tet	106-118	synuclein, alpha	Mus musculus	189-198
22570336-3	2012	To determine the early molecular mechanisms causing motor neuron degeneration in SBMA, we established an in vitro system based on the tetracycline-inducible expression of normal (AR20Q), the mutated, 51 glutamine-extended (AR51Q), or polyQ-deleted (AR0Q) AR in NSC34, a motor neuron-like cell line lacking endogenous AR.	tet	134-146	androgen receptor	Mus musculus	179-181
22570336-3	2012	To determine the early molecular mechanisms causing motor neuron degeneration in SBMA, we established an in vitro system based on the tetracycline-inducible expression of normal (AR20Q), the mutated, 51 glutamine-extended (AR51Q), or polyQ-deleted (AR0Q) AR in NSC34, a motor neuron-like cell line lacking endogenous AR.	tet	134-146	androgen receptor	Mus musculus	223-225
22919212-0	2012	Effect of locally delivered tetracycline hydrochloride as an adjunct to scaling and root planing on Hba1c, C-reactive protein, and lipid profile in type 2 diabetes: A clinico-biochemical study.	tet	28-54	C-reactive protein	Homo sapiens	107-125
22272661-6	2012	We generated a HEK293 cell line stably expressing the alpha1A subunit of the P/Q-type calcium channel under control of a tetracycline (Tet) promoter.	tet	121-133	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	54-61
22272661-6	2012	We generated a HEK293 cell line stably expressing the alpha1A subunit of the P/Q-type calcium channel under control of a tetracycline (Tet) promoter.	tet	135-138	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	54-61
22378487-5	2012	To this end, we overexpressed PDEF in PC3 human prostate cells using a tetracycline inducible system (Tet-On).	tet	71-83	SAM pointed domain containing ETS transcription factor	Homo sapiens	30-34
22338080-2	2012	To directly evaluate the repercussion of increased OGFr expression and consequent gain-of-function in epithelium, bovine keratin 5 promoter elements were used to direct the expression of OGFr to skin in a tetracycline-regulated manner.	tet	205-217	opioid growth factor receptor	Bos taurus	187-191
22465424-6	2012	To distinguish the roles of CTR1 and DMT1 in Cu transport, the Z310 cell-based tetracycline (Tet)-inducible CTR1 and DMT1 expression cell lines were developed, namely iZCTR1 and iZDMT1 cells, respectively.	tet	79-91	solute carrier family 31 member 1	Rattus norvegicus	108-112
22465424-6	2012	To distinguish the roles of CTR1 and DMT1 in Cu transport, the Z310 cell-based tetracycline (Tet)-inducible CTR1 and DMT1 expression cell lines were developed, namely iZCTR1 and iZDMT1 cells, respectively.	tet	79-91	RoBo-1	Rattus norvegicus	117-121
22465424-6	2012	To distinguish the roles of CTR1 and DMT1 in Cu transport, the Z310 cell-based tetracycline (Tet)-inducible CTR1 and DMT1 expression cell lines were developed, namely iZCTR1 and iZDMT1 cells, respectively.	tet	93-96	solute carrier family 31 member 1	Rattus norvegicus	108-112
22465424-6	2012	To distinguish the roles of CTR1 and DMT1 in Cu transport, the Z310 cell-based tetracycline (Tet)-inducible CTR1 and DMT1 expression cell lines were developed, namely iZCTR1 and iZDMT1 cells, respectively.	tet	93-96	RoBo-1	Rattus norvegicus	117-121
22465424-7	2012	In iZCTR1 cells, Tet induction led to a robust increase (25 fold) of 64Cu uptake with the time course corresponding to the increased CTR1.	tet	17-20	solute carrier family 31 member 1	Rattus norvegicus	5-9
22465424-8	2012	Induction of DMT1 by Tet in iZDMT1 cells, however, resulted in only a slight increase of 64Cu uptake in contrast to a substantial increase in DMT1 mRNA and protein expression.	tet	21-24	RoBo-1	Rattus norvegicus	13-17
22465424-8	2012	Induction of DMT1 by Tet in iZDMT1 cells, however, resulted in only a slight increase of 64Cu uptake in contrast to a substantial increase in DMT1 mRNA and protein expression.	tet	21-24	RoBo-1	Rattus norvegicus	30-34
22285229-4	2012	Human TRPC4 and TRPC5 cDNAs in tetracycline-regulated vectors were transfected into HEK293 T-REx cells.	tet	31-43	transient receptor potential cation channel subfamily C member 5	Homo sapiens	16-21
22887082-7	2012	The modified CE-LIF method was found to be less complicated and more sensitive than the best current methods using UV or LIF detection, and has been applied successfully to assess oral absorption of DC in swine and chickens and to confirm suspected TC-positive bovine serum samples.	tet	249-251	LIF interleukin 6 family cytokine	Sus scrofa	16-19
22496374-4	2012	In Madin-Darby canine kidney cells stably expressing epitope-tagged alphabetagamma-ENaC and with tetracycline-inducible overexpression of Hsp70, treatment with 1 or 2 mug/ml doxycycline increased total Hsp70 expression ~2-fold and ENaC functional expression ~1.4-fold.	tet	97-109	heat shock 70 kDa protein 1	Canis lupus familiaris	138-143
22389449-7	2012	Hypoxic cells containing VDAC1-DeltaC were less sensitive to staurosporine- and etoposide-induced cell death, and silencing of VDAC1-DeltaC or treatment with the tetracycline antibiotics restored sensitivity.	tet	162-174	voltage dependent anion channel 1	Homo sapiens	25-30
22389449-7	2012	Hypoxic cells containing VDAC1-DeltaC were less sensitive to staurosporine- and etoposide-induced cell death, and silencing of VDAC1-DeltaC or treatment with the tetracycline antibiotics restored sensitivity.	tet	162-174	voltage dependent anion channel 1	Homo sapiens	127-132
22156940-3	2012	We reproduced the enzyme defect of MPSIIIB in HeLa cells using tetracycline-inducible expression of shRNAs directed against alpha-N-acetylglucosaminidase (NAGLU) and addressed this hypothesis.	tet	63-75	N-acetyl-alpha-glucosaminidase	Homo sapiens	35-42
22156940-3	2012	We reproduced the enzyme defect of MPSIIIB in HeLa cells using tetracycline-inducible expression of shRNAs directed against alpha-N-acetylglucosaminidase (NAGLU) and addressed this hypothesis.	tet	63-75	N-acetyl-alpha-glucosaminidase	Homo sapiens	124-153
22156940-3	2012	We reproduced the enzyme defect of MPSIIIB in HeLa cells using tetracycline-inducible expression of shRNAs directed against alpha-N-acetylglucosaminidase (NAGLU) and addressed this hypothesis.	tet	63-75	N-acetyl-alpha-glucosaminidase	Homo sapiens	155-160
22257482-4	2012	Expression of native apoA-IV using either a constitutive or tetracycline-inducible promoter delayed the initial rate of apoB secretion and reduced the final secretion efficiency by ~40%.	tet	60-72	apolipoprotein A4	Rattus norvegicus	21-28
22664438-0	2012	ermA, ermC , tetM and tetK are essential for erythromycin and tetracycline resistance among methicillin-resistant Staphylococcus aureus strains isolated from a tertiary hospital in Malaysia.	tet	62-74	ErmC	Staphylococcus aureus	6-10
22257482-4	2012	Expression of native apoA-IV using either a constitutive or tetracycline-inducible promoter delayed the initial rate of apoB secretion and reduced the final secretion efficiency by ~40%.	tet	60-72	apolipoprotein B	Rattus norvegicus	120-124
21864674-4	2012	Here we report, that SHIP1 can be detected in nuclear puncta of Jurkat cells by confocal microscopy after expression of SHIP1 from a tetracycline inducible vector.	tet	133-145	inositol polyphosphate-5-phosphatase D	Homo sapiens	21-26
21864674-4	2012	Here we report, that SHIP1 can be detected in nuclear puncta of Jurkat cells by confocal microscopy after expression of SHIP1 from a tetracycline inducible vector.	tet	133-145	inositol polyphosphate-5-phosphatase D	Homo sapiens	120-125
22002421-3	2012	With this aim in mind, the authors generated an inducible cell line using the tetracycline-responsive gene expression system to mimic the effects of therapeutic inhibition of the IGF-1R both in vitro and on established tumors in vivo.	tet	78-90	insulin-like growth factor I receptor	Mus musculus	179-185
22125260-6	2012	Further analyses of specific classes showed an increased risk of CL/P associated with 2nd month use of doxycycline/tetracycline (2 exposed cases; POR, 7.30; 95%CI, 1.81-29.46) and sulfamethizole (18 exposed cases; POR, 1.76; 95%CI, 1.10-2.81).	tet	115-127	cytochrome p450 oxidoreductase	Homo sapiens	214-217
22349704-6	2012	Tetracycline-controlled expression of Bim impaired mitochondrial respiration and caused ROS production, suggesting that FOXO3 induces uncoupling of mitochondrial respiration through Bim.	tet	0-12	forkhead box O3	Homo sapiens	120-125
22037589-7	2012	Increased susceptibility to 3-NP was also detected in stably transfected PC6-3 cells that inducibly express expanded (Q108) ataxin-3 in a tetracycline-regulated manner.	tet	138-150	ataxin 3	Rattus norvegicus	124-132
22000550-2	2012	Previous studies have utilized a constitutive HoxB4 expression system or tetracycline-regulated HoxB4 expression system to induce hematopoietic cells from ES cells.	tet	73-85	homeobox B4	Mus musculus	96-101
22316320-5	2012	In the current study, we generated transgenic mice in which the expression of dominant-negative RAR (dnRAR) could be induced in the mature brain using a tetracycline-dependent transcription factor and examined the effects of RAR/RXR loss.	tet	153-165	retinoic acid receptor, alpha	Mus musculus	96-99
21876558-2	2012	Using a tetracycline inducible model, we show that activation of K-ras(G12V) causes mitochondrial dysfunction, leading to decreased respiration, elevated glycolysis, and increased generation of reactive oxygen species.	tet	8-20	KRAS proto-oncogene, GTPase	Homo sapiens	65-70
22219353-2	2012	Conditional Bmp4 overexpression, using a tetracycline-regulated Bmp4 gain-of-function allele, resulted in facial skeletal changes that were most dramatic after an E10.5 Bmp4 induction.	tet	41-53	bone morphogenetic protein 4	Homo sapiens	12-16
22219353-2	2012	Conditional Bmp4 overexpression, using a tetracycline-regulated Bmp4 gain-of-function allele, resulted in facial skeletal changes that were most dramatic after an E10.5 Bmp4 induction.	tet	41-53	bone morphogenetic protein 4	Homo sapiens	64-68
22219353-2	2012	Conditional Bmp4 overexpression, using a tetracycline-regulated Bmp4 gain-of-function allele, resulted in facial skeletal changes that were most dramatic after an E10.5 Bmp4 induction.	tet	41-53	bone morphogenetic protein 4	Homo sapiens	64-68
21982523-3	2012	METHODS: We created a transgenic mouse expressing a degradation resistant N-terminally deleted IkappaBalpha (DeltaNIkappaBalpha) under the control of a commercially available tetracycline-controlled transcriptional activation system using a rat insulin promoter.	tet	175-187	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	95-107
22261821-5	2012	Here, the role of ASAH1 in regulating steroidogenic capacity was examined using a tetracycline-inducible ASAH1 short hairpin RNA H295R human adrenocortical stable cell line.	tet	82-94	N-acylsphingosine amidohydrolase 1	Homo sapiens	18-23
22261821-5	2012	Here, the role of ASAH1 in regulating steroidogenic capacity was examined using a tetracycline-inducible ASAH1 short hairpin RNA H295R human adrenocortical stable cell line.	tet	82-94	N-acylsphingosine amidohydrolase 1	Homo sapiens	105-110
22148555-3	2012	Utilizing a fully synthetic route to tetracycline analogues, the C-9 side-chain of the fluorocyclines was optimized for both antibacterial activity and oral efficacy.	tet	37-49	complement C9	Rattus norvegicus	65-68
22531515-2	2012	MATERIALS AND METHODS: An AGS cell system with tetracycline-inducible IRF-1 expression (AGS/IRF-1) was established.	tet	47-59	jagged canonical Notch ligand 1	Homo sapiens	26-29
22166213-4	2012	In this study, we found that the deletion of SCS7 results in the enhancement of growth inhibition due to repression of AUR1 expression under the control of a tetracycline-regulatable promoter, whereas the deletion of SUR2 attenuates the growth inhibition.	tet	158-170	fatty acid alpha-hydroxylase	Saccharomyces cerevisiae S288C	45-49
22166213-4	2012	In this study, we found that the deletion of SCS7 results in the enhancement of growth inhibition due to repression of AUR1 expression under the control of a tetracycline-regulatable promoter, whereas the deletion of SUR2 attenuates the growth inhibition.	tet	158-170	inositol phosphorylceramide synthase	Saccharomyces cerevisiae S288C	119-123
22024822-2	2012	Doxycycline is a tetracycline antibiotic that inhibits matrix metalloproteinase 9, a protease known to be associated with the severity of lung disease in CF.	tet	17-29	matrix metallopeptidase 9	Homo sapiens	55-81
23047106-0	2012	Establishment of tetracycline-inducible, survivin-expressing CHO cell lines by an optimized screening method.	tet	17-29	survivin	Cricetulus griseus	41-49
23047106-5	2012	DNA laddering and annexin V/PI staining assays further indicated that although tetracycline-inducible expression of survivin conferred resistance to NH4Cl- and staurosporine-induced apoptosis in both the B2- and the B5-derived stable cell lines, the B2-derived cell lines showed more stringent regulation in the absence of tetracycline.	tet	79-91	survivin	Cricetulus griseus	116-124
23047106-5	2012	DNA laddering and annexin V/PI staining assays further indicated that although tetracycline-inducible expression of survivin conferred resistance to NH4Cl- and staurosporine-induced apoptosis in both the B2- and the B5-derived stable cell lines, the B2-derived cell lines showed more stringent regulation in the absence of tetracycline.	tet	323-335	survivin	Cricetulus griseus	116-124
22079830-4	2012	We established a co-culture system in which HEK293 cells stably expressing one copy of tetracycline-regulated NOTCH3 were cultured with NOTCH3 ligand Jagged1 (Jag1)-expressing HEK293 cells.	tet	87-99	notch receptor 3	Homo sapiens	110-116
22079830-4	2012	We established a co-culture system in which HEK293 cells stably expressing one copy of tetracycline-regulated NOTCH3 were cultured with NOTCH3 ligand Jagged1 (Jag1)-expressing HEK293 cells.	tet	87-99	notch receptor 3	Homo sapiens	136-142
22079830-4	2012	We established a co-culture system in which HEK293 cells stably expressing one copy of tetracycline-regulated NOTCH3 were cultured with NOTCH3 ligand Jagged1 (Jag1)-expressing HEK293 cells.	tet	87-99	jagged canonical Notch ligand 1	Homo sapiens	159-163
22719175-6	2012	After H/R with vehicle or tetracycline, ALT increased to 4538 U/L and 3999 U/L, respectively, which minocycline decreased to 1763 U/L (P &lt; 0.01).	tet	26-38	glutamic pyruvic transaminase, soluble	Mus musculus	40-43
22719175-9	2012	Minocycline and tetracycline also decreased caspase-3 activity in liver homogenates.	tet	16-28	caspase 3	Mus musculus	44-53
21477461-1	2012	Electrospun tetracycline (Tet)-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanofibers are considered to have great potential as local drug-delivery systems.	tet	12-24	tetracycline-resistance protein	Staphylococcus aureus	26-29
22250205-4	2012	In this study we examine the interface between normal and Scribble-knockdown epithelial cells using Madin-Darby Canine Kidney (MDCK) cells expressing Scribble short hairpin RNA (shRNA) in a tetracycline-inducible manner.	tet	190-202	scribble	Drosophila melanogaster	150-158
22531515-2	2012	MATERIALS AND METHODS: An AGS cell system with tetracycline-inducible IRF-1 expression (AGS/IRF-1) was established.	tet	47-59	interferon regulatory factor 1	Homo sapiens	70-75
22531515-2	2012	MATERIALS AND METHODS: An AGS cell system with tetracycline-inducible IRF-1 expression (AGS/IRF-1) was established.	tet	47-59	jagged canonical Notch ligand 1	Homo sapiens	88-91
22531515-2	2012	MATERIALS AND METHODS: An AGS cell system with tetracycline-inducible IRF-1 expression (AGS/IRF-1) was established.	tet	47-59	interferon regulatory factor 1	Homo sapiens	92-97
22531515-5	2012	RESULTS: IRF-1 mRNA and protein level were significantly increased in AGS/IRF-1 cells induced with tetracycline.	tet	99-111	interferon regulatory factor 1	Homo sapiens	9-14
22531515-5	2012	RESULTS: IRF-1 mRNA and protein level were significantly increased in AGS/IRF-1 cells induced with tetracycline.	tet	99-111	jagged canonical Notch ligand 1	Homo sapiens	70-73
22531515-5	2012	RESULTS: IRF-1 mRNA and protein level were significantly increased in AGS/IRF-1 cells induced with tetracycline.	tet	99-111	interferon regulatory factor 1	Homo sapiens	74-79
22673307-0	2012	Tetracycline resistance and presence of tetracycline resistance determinants tet(V) and tap in rapidly growing mycobacteria from agricultural soils and clinical isolates.	tet	40-52	nuclear RNA export factor 1	Homo sapiens	88-91
22131000-4	2012	A tet-responsive transcription unit, encoding a designed miRNA against human lamin A/C, is directly placed into a predefined genomic site of our previously developed cell line HeLa-EM2-11ht.	tet	2-5	lamin A/C	Homo sapiens	77-86
21696760-4	2012	MATERIALS AND METHODS: We generated triple transgenic mice that express the soluble VEGF receptor, (sFlt-1), specifically in the mesenchyme (dermo-1(Cre)- tetracycline reverse transcriptional activator (rtTA)(flox/flox)-tet(0)-sflt-1).	tet	155-167	vascular endothelial growth factor A	Mus musculus	84-88
21696760-4	2012	MATERIALS AND METHODS: We generated triple transgenic mice that express the soluble VEGF receptor, (sFlt-1), specifically in the mesenchyme (dermo-1(Cre)- tetracycline reverse transcriptional activator (rtTA)(flox/flox)-tet(0)-sflt-1).	tet	155-167	FMS-like tyrosine kinase 1	Mus musculus	100-106
22808728-12	2012	Drugs with the highest efficiency against K. pneumoniae ESBL(+), in our in vitro studies, were: imipenem (100%), meropenem (100%), amikacin (90%) and tetracycline (75%).	tet	150-162	EsbL	Escherichia coli	56-60
22673307-9	2012	In certain cases, tet(V) and/or tap were found in TET-sensitive isolates, or inversely, were not found in resistant strains.	tet	50-53	nuclear RNA export factor 1	Homo sapiens	32-35
23236396-6	2012	TGF-beta signaling was less efficient in DeltaNp73 downregulated cells, whereas tetracycline induced DeltaNp73 increased expression of endogenous TGF-beta regulated genes PAI-1 and Col1a1.	tet	80-92	collagen type I alpha 1 chain	Homo sapiens	181-187
23236396-6	2012	TGF-beta signaling was less efficient in DeltaNp73 downregulated cells, whereas tetracycline induced DeltaNp73 increased expression of endogenous TGF-beta regulated genes PAI-1 and Col1a1.	tet	80-92	serpin family E member 1	Homo sapiens	171-176
23209758-5	2012	In this work we developed a conditional tetracycline inducible system controlling the expression of the human NOTCH ligand Delta-like 1 in the murine stromal MS5 cells.	tet	40-52	delta like canonical Notch ligand 1	Mus musculus	123-135
22808264-6	2012	The first novel finding is that stable transfection of MCF-7 cells with ACSL4 using the tetracycline Tet-Off system of MCF-7 cells resulted in development of growing tumors when injected into nude mice.	tet	88-100	acyl-CoA synthetase long chain family member 4	Homo sapiens	72-77
23077629-4	2012	We also established RTF-Pdx1-EGFP mice, which ubiquitously express Pdx1 when tetracycline is removed from the drinking water.	tet	77-89	pancreatic and duodenal homeobox 1	Mus musculus	67-71
22745670-12	2012	Notably, strains belonging to these three spa types exhibited high levels of tetracycline resistance (45.9%).	tet	77-89	surfactant protein A2	Homo sapiens	42-45
22363422-6	2012	The analysis of a tetracycline-regulated LacZ reporter gene shows that in BAC-Pdx1-itTA mice, itTA is expressed from embryonic (E) day 11.5 in all pancreatic precursor cells.	tet	18-30	pancreatic and duodenal homeobox 1	Mus musculus	74-87
22693598-5	2012	Here, we generated a transactivator (tTA) mouse line (TPH2-tTA) that allows temporal and spatial control of tetracycline (Ptet) controlled transgene expression as well as gene deletion in 5-HT neurons.	tet	108-120	tryptophan hydroxylase 2	Mus musculus	54-58
22574202-3	2012	METHODOLOGY/PRINCIPAL FINDINGS: In this work, we utilized a stable tetracycline-inducible RNA interfering system targeting the core 1 ss1,3-galactosyltransferase (C1galt1 or T-synthase), a critical galactosyltransferase required for the synthesis of core 1 O-glycans, to explore the role of mucin-type carbohydrates in apical endocytic trafficking in human corneal keratinocytes.	tet	67-79	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	163-170
22574202-3	2012	METHODOLOGY/PRINCIPAL FINDINGS: In this work, we utilized a stable tetracycline-inducible RNA interfering system targeting the core 1 ss1,3-galactosyltransferase (C1galt1 or T-synthase), a critical galactosyltransferase required for the synthesis of core 1 O-glycans, to explore the role of mucin-type carbohydrates in apical endocytic trafficking in human corneal keratinocytes.	tet	67-79	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	174-184
22574202-3	2012	METHODOLOGY/PRINCIPAL FINDINGS: In this work, we utilized a stable tetracycline-inducible RNA interfering system targeting the core 1 ss1,3-galactosyltransferase (C1galt1 or T-synthase), a critical galactosyltransferase required for the synthesis of core 1 O-glycans, to explore the role of mucin-type carbohydrates in apical endocytic trafficking in human corneal keratinocytes.	tet	67-79	LOC100508689	Homo sapiens	291-296
22363791-7	2012	SESN2 overexpression was achieved using a Flag-tagged SESN2 expression vector or a stably-integrated tetracycline-inducible system, which also increased AMPKalpha1 and AMPKbeta1 subunit phosphorylation, and co-localized with phosphorylated AMPKalpha-Thr127 in the cytoplasm.	tet	101-113	sestrin 2	Homo sapiens	0-5
22363791-7	2012	SESN2 overexpression was achieved using a Flag-tagged SESN2 expression vector or a stably-integrated tetracycline-inducible system, which also increased AMPKalpha1 and AMPKbeta1 subunit phosphorylation, and co-localized with phosphorylated AMPKalpha-Thr127 in the cytoplasm.	tet	101-113	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	153-163
22363791-7	2012	SESN2 overexpression was achieved using a Flag-tagged SESN2 expression vector or a stably-integrated tetracycline-inducible system, which also increased AMPKalpha1 and AMPKbeta1 subunit phosphorylation, and co-localized with phosphorylated AMPKalpha-Thr127 in the cytoplasm.	tet	101-113	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	168-177
22169319-2	2011	To date, a number of BCR/ABL transgenic animal models have been established using different promoter or tetracycline-controlling system.	tet	104-116	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	21-28
22100648-4	2011	Infection-induced expression of ISG15 and UBP43 requires intracellular replication of rickettsiae and production of IFN-beta, because treatment with tetracycline and presence of an antibody capable of neutralizing IFN-beta activity resulted in near complete attenuation of both responses.	tet	149-161	ISG15 ubiquitin like modifier	Homo sapiens	32-37
22100648-4	2011	Infection-induced expression of ISG15 and UBP43 requires intracellular replication of rickettsiae and production of IFN-beta, because treatment with tetracycline and presence of an antibody capable of neutralizing IFN-beta activity resulted in near complete attenuation of both responses.	tet	149-161	ubiquitin specific peptidase 18	Homo sapiens	42-47
21965680-1	2011	SsfX3 is a GDSL family acyltransferase that transfers salicylate to the C-4 hydroxyl of a tetracycline intermediate in the penultimate step during biosynthesis of the anticancer natural product SF2575.	tet	90-102	complement C4A (Rodgers blood group)	Homo sapiens	72-75
21965680-2	2011	The C-4 salicylate takes the place of the more common C-4 dimethylamine functionality, making SsfX3 the first acyltransferase identified to act on a tetracycline substrate.	tet	149-161	complement C4A (Rodgers blood group)	Homo sapiens	4-7
21965680-2	2011	The C-4 salicylate takes the place of the more common C-4 dimethylamine functionality, making SsfX3 the first acyltransferase identified to act on a tetracycline substrate.	tet	149-161	complement C4A (Rodgers blood group)	Homo sapiens	54-57
21590687-3	2011	METHODS: A tetracycline-regulated TrkB-expressing isogenic NB cell model system was tested.	tet	11-23	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	34-38
22358401-12	2011	A correlation was found between resistance to tetracycline (56.0%) and presence of the tet(M) (75.1%) and tet(L) genes (7.0%), while resistance to erythromycin (34.1%) was due to the erm(B) gene (70.9%).	tet	46-58	erythromycin resistance protein	Enterococcus faecalis	183-189
22016507-5	2011	We used a tetracycline inducible ovarian cancer cell culture model to show the effects of hVps37A knockdown in vitro and in vivo.	tet	10-22	VPS37A subunit of ESCRT-I	Homo sapiens	90-97
21976680-8	2011	Tetracycline treatment induced CD24 expression in a dose- and time-dependent fashion, which was abrogated following treatment with anti-CD24 monoclonal antibodies (mAbs).	tet	0-12	CD24 molecule	Homo sapiens	31-35
21976680-8	2011	Tetracycline treatment induced CD24 expression in a dose- and time-dependent fashion, which was abrogated following treatment with anti-CD24 monoclonal antibodies (mAbs).	tet	0-12	CD24 molecule	Homo sapiens	136-140
21976680-11	2011	The CD24 Tet-On system is a good model to unravel the role and underlying CD24 pathogenesis in vivo.	tet	9-12	CD24 molecule	Homo sapiens	4-8
21976680-11	2011	The CD24 Tet-On system is a good model to unravel the role and underlying CD24 pathogenesis in vivo.	tet	9-12	CD24 molecule	Homo sapiens	74-78
21937702-4	2011	In the present study, we genetically engineered human blood-derived endothelial colony-forming cells (ECFCs) to express erythropoietin (EPO) under the control of a tetracycline-regulated system, and generated subcutaneous vascular networks capable of systemic EPO release in immunodeficient mice.	tet	164-176	erythropoietin	Homo sapiens	120-134
21937702-4	2011	In the present study, we genetically engineered human blood-derived endothelial colony-forming cells (ECFCs) to express erythropoietin (EPO) under the control of a tetracycline-regulated system, and generated subcutaneous vascular networks capable of systemic EPO release in immunodeficient mice.	tet	164-176	erythropoietin	Homo sapiens	136-139
22051109-12	2011	To study the molecular mechanisms controlling Paxillin expression, MDCK cells expressing E-cadherin shRNA in a tetracycline-inducible manner was employed.	tet	111-123	cadherin 1	Canis lupus familiaris	89-99
21983942-2	2011	Here we show that sealing BBB TJs by ectopic tetracycline-regulated expression of the TJ protein claudin-1 in Tie-2 tTA//TRE-claudin-1 double transgenic C57BL/6 mice had no influence on immune cell trafficking across the BBB during EAE and furthermore did not influence the onset and severity of the first clinical disease episode.	tet	45-57	claudin 1	Mus musculus	97-106
21983942-2	2011	Here we show that sealing BBB TJs by ectopic tetracycline-regulated expression of the TJ protein claudin-1 in Tie-2 tTA//TRE-claudin-1 double transgenic C57BL/6 mice had no influence on immune cell trafficking across the BBB during EAE and furthermore did not influence the onset and severity of the first clinical disease episode.	tet	45-57	TEK receptor tyrosine kinase	Mus musculus	110-115
21983942-2	2011	Here we show that sealing BBB TJs by ectopic tetracycline-regulated expression of the TJ protein claudin-1 in Tie-2 tTA//TRE-claudin-1 double transgenic C57BL/6 mice had no influence on immune cell trafficking across the BBB during EAE and furthermore did not influence the onset and severity of the first clinical disease episode.	tet	45-57	claudin 1	Mus musculus	125-134
21945411-4	2011	To determine the function of BP1 in vivo, we generated tetracycline-regulated conditional BP1 transgenic mice.	tet	55-67	BP1	Homo sapiens	29-32
21945411-4	2011	To determine the function of BP1 in vivo, we generated tetracycline-regulated conditional BP1 transgenic mice.	tet	55-67	BP1	Homo sapiens	90-93
21889481-3	2011	Using tetracycline (Tet)-regulated monoclonal cell models that express CUG and CCUG repeats, we found that low levels of long CUG and CCUG repeats result in nuclear and cytoplasmic RNA aggregation with a simultaneous increase of CUGBP1 and a reduction of ZNF9.	tet	6-18	CUGBP Elav-like family member 1	Homo sapiens	229-235
21499299-8	2011	To further investigate the functions and mechanisms of NANOG in tumorigenesis, we established tetracycline-inducible NANOG-overexpressing cancer cell lines, including both PCa (Du145 and LNCaP) and breast (MCF-7) cancer cells.	tet	94-106	Nanog homeobox	Homo sapiens	55-60
21889481-3	2011	Using tetracycline (Tet)-regulated monoclonal cell models that express CUG and CCUG repeats, we found that low levels of long CUG and CCUG repeats result in nuclear and cytoplasmic RNA aggregation with a simultaneous increase of CUGBP1 and a reduction of ZNF9.	tet	6-18	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	255-259
21889481-3	2011	Using tetracycline (Tet)-regulated monoclonal cell models that express CUG and CCUG repeats, we found that low levels of long CUG and CCUG repeats result in nuclear and cytoplasmic RNA aggregation with a simultaneous increase of CUGBP1 and a reduction of ZNF9.	tet	20-23	CUGBP Elav-like family member 1	Homo sapiens	229-235
21889481-3	2011	Using tetracycline (Tet)-regulated monoclonal cell models that express CUG and CCUG repeats, we found that low levels of long CUG and CCUG repeats result in nuclear and cytoplasmic RNA aggregation with a simultaneous increase of CUGBP1 and a reduction of ZNF9.	tet	20-23	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	255-259
21969595-4	2011	Many of the recurring lymphomas (76%) harbored mutations in the tetracycline transactivator, resulting in expression of the MYC transgene even in the presence of doxycycline.	tet	64-76	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	124-127
21828043-6	2011	In stable C2C12 mesenchymal cells using the tetracycline (Tet)-Off system, overexpression of Osx stimulated Satb2 expression.	tet	44-56	Sp7 transcription factor 7	Mus musculus	93-96
21828043-6	2011	In stable C2C12 mesenchymal cells using the tetracycline (Tet)-Off system, overexpression of Osx stimulated Satb2 expression.	tet	58-61	Sp7 transcription factor 7	Mus musculus	93-96
21828043-6	2011	In stable C2C12 mesenchymal cells using the tetracycline (Tet)-Off system, overexpression of Osx stimulated Satb2 expression.	tet	58-61	special AT-rich sequence binding protein 2	Mus musculus	108-113
21717087-3	2011	We have generated an Hsp60 variant with a mutation (Asp423Ala) in the ATPase domain and established a stable human embryonic kidney (HEK293) cell line allowing tetracycline-controlled expression of this mutant variant.	tet	160-172	heat shock protein family D (Hsp60) member 1	Homo sapiens	21-26
20820817-1	2011	PURPOSE: Previous studies suggest tetracycline and other antibiotics lessen the severity of epidermal growth factor receptor (EGFR) inhibitor-induced rash.	tet	34-46	epidermal growth factor receptor	Homo sapiens	92-124
20820817-1	2011	PURPOSE: Previous studies suggest tetracycline and other antibiotics lessen the severity of epidermal growth factor receptor (EGFR) inhibitor-induced rash.	tet	34-46	epidermal growth factor receptor	Homo sapiens	126-130
21499299-8	2011	To further investigate the functions and mechanisms of NANOG in tumorigenesis, we established tetracycline-inducible NANOG-overexpressing cancer cell lines, including both PCa (Du145 and LNCaP) and breast (MCF-7) cancer cells.	tet	94-106	Nanog homeobox	Homo sapiens	117-122
21628326-3	2011	METHODS AND RESULTS: We generated transgenic mice in which a tetracycline-regulated constitutively active FoxO3 transgene (FoxO3-CA) is controlled by the heart-specific alpha-myosin heavy chain promoter.	tet	61-73	forkhead box O3	Mus musculus	106-111
21677144-10	2011	Moreover, depletion of Gal-7 using tetracycline-induced short-hairpin RNA in mpkCCD(c14) cells significantly reduced cilia length and slowed wound healing in a scratch assay.	tet	35-47	lectin, galactose binding, soluble 7	Mus musculus	23-28
21846918-6	2011	All 3 patients recovered after biopsy and tetracycline-based therapy.	tet	42-54	paired box 5	Homo sapiens	0-5
21628326-3	2011	METHODS AND RESULTS: We generated transgenic mice in which a tetracycline-regulated constitutively active FoxO3 transgene (FoxO3-CA) is controlled by the heart-specific alpha-myosin heavy chain promoter.	tet	61-73	forkhead box O3	Mus musculus	123-128
21705546-1	2011	Salmonella genomic island 1 (SGI1) contains a multidrug resistance region conferring the ampicillin-chloramphenicol-streptomycin-sulfamethoxazole-tetracycline resistance phenotype encoded by bla(PSE-1), floR, aadA2, sul1, and tet(G).	tet	146-158	FloR	Salmonella enterica	203-207
21959447-7	2011	Results from the Western blot analysis showed that TC, MINO, and DOXY reduced the expression of BMP-2 and ER-beta.	tet	51-53	bone morphogenetic protein 2	Homo sapiens	96-101
21959447-7	2011	Results from the Western blot analysis showed that TC, MINO, and DOXY reduced the expression of BMP-2 and ER-beta.	tet	51-53	estrogen receptor 2	Homo sapiens	106-113
21333374-3	2011	Therefore, we created a tetracycline inducible expression system of wild-type PTEN (PTEN-WT) as well as catalytically (PTEN-G129R) and lipid phosphatase (PTEN-G129E) inactive PTEN mutants using the PC14, PC9 and PC3 lung adenocarcinoma cell lines, in which endogenous PTEN expression was not detected and AKT at Ser473 was phosphorylated by Western blot analysis.	tet	24-36	phosphatase and tensin homolog	Homo sapiens	78-82
21333374-3	2011	Therefore, we created a tetracycline inducible expression system of wild-type PTEN (PTEN-WT) as well as catalytically (PTEN-G129R) and lipid phosphatase (PTEN-G129E) inactive PTEN mutants using the PC14, PC9 and PC3 lung adenocarcinoma cell lines, in which endogenous PTEN expression was not detected and AKT at Ser473 was phosphorylated by Western blot analysis.	tet	24-36	phosphatase and tensin homolog	Homo sapiens	84-91
21333374-3	2011	Therefore, we created a tetracycline inducible expression system of wild-type PTEN (PTEN-WT) as well as catalytically (PTEN-G129R) and lipid phosphatase (PTEN-G129E) inactive PTEN mutants using the PC14, PC9 and PC3 lung adenocarcinoma cell lines, in which endogenous PTEN expression was not detected and AKT at Ser473 was phosphorylated by Western blot analysis.	tet	24-36	phosphatase and tensin homolog	Homo sapiens	84-88
21333374-3	2011	Therefore, we created a tetracycline inducible expression system of wild-type PTEN (PTEN-WT) as well as catalytically (PTEN-G129R) and lipid phosphatase (PTEN-G129E) inactive PTEN mutants using the PC14, PC9 and PC3 lung adenocarcinoma cell lines, in which endogenous PTEN expression was not detected and AKT at Ser473 was phosphorylated by Western blot analysis.	tet	24-36	phosphatase and tensin homolog	Homo sapiens	84-88
21333374-3	2011	Therefore, we created a tetracycline inducible expression system of wild-type PTEN (PTEN-WT) as well as catalytically (PTEN-G129R) and lipid phosphatase (PTEN-G129E) inactive PTEN mutants using the PC14, PC9 and PC3 lung adenocarcinoma cell lines, in which endogenous PTEN expression was not detected and AKT at Ser473 was phosphorylated by Western blot analysis.	tet	24-36	phosphatase and tensin homolog	Homo sapiens	84-88
21333374-3	2011	Therefore, we created a tetracycline inducible expression system of wild-type PTEN (PTEN-WT) as well as catalytically (PTEN-G129R) and lipid phosphatase (PTEN-G129E) inactive PTEN mutants using the PC14, PC9 and PC3 lung adenocarcinoma cell lines, in which endogenous PTEN expression was not detected and AKT at Ser473 was phosphorylated by Western blot analysis.	tet	24-36	proprotein convertase subtilisin/kexin type 9	Homo sapiens	204-207
21333374-3	2011	Therefore, we created a tetracycline inducible expression system of wild-type PTEN (PTEN-WT) as well as catalytically (PTEN-G129R) and lipid phosphatase (PTEN-G129E) inactive PTEN mutants using the PC14, PC9 and PC3 lung adenocarcinoma cell lines, in which endogenous PTEN expression was not detected and AKT at Ser473 was phosphorylated by Western blot analysis.	tet	24-36	phosphatase and tensin homolog	Homo sapiens	84-88
21333374-3	2011	Therefore, we created a tetracycline inducible expression system of wild-type PTEN (PTEN-WT) as well as catalytically (PTEN-G129R) and lipid phosphatase (PTEN-G129E) inactive PTEN mutants using the PC14, PC9 and PC3 lung adenocarcinoma cell lines, in which endogenous PTEN expression was not detected and AKT at Ser473 was phosphorylated by Western blot analysis.	tet	24-36	AKT serine/threonine kinase 1	Homo sapiens	305-308
21849551-6	2011	Using a tetracycline-inducible promoter Tet-Off system, we generated transgenic mice in which FAF1 is specifically expressed in immature olfactory sensory neurons (OSNs) and show that overexpression of FAF1 not only misroutes OSN axons to deep layers of the olfactory bulb but also leads to widespread disruption of the glomerular layer.	tet	8-20	Fas-associated factor 1	Mus musculus	94-98
21849551-6	2011	Using a tetracycline-inducible promoter Tet-Off system, we generated transgenic mice in which FAF1 is specifically expressed in immature olfactory sensory neurons (OSNs) and show that overexpression of FAF1 not only misroutes OSN axons to deep layers of the olfactory bulb but also leads to widespread disruption of the glomerular layer.	tet	8-20	Fas-associated factor 1	Mus musculus	202-206
21669931-3	2011	Recently, a study in the mouse FXS model showed that the tetracycline derivative minocycline effectively remediates the disease state via a proposed matrix metalloproteinase (MMP) inhibition mechanism.	tet	57-69	Matrix metalloproteinase 2	Drosophila melanogaster	149-173
21669931-3	2011	Recently, a study in the mouse FXS model showed that the tetracycline derivative minocycline effectively remediates the disease state via a proposed matrix metalloproteinase (MMP) inhibition mechanism.	tet	57-69	Matrix metalloproteinase 2	Drosophila melanogaster	175-178
21645183-11	2011	Tetracycline-resistant E. coli strains with sul1 and tet(A) genes were more likely to harbour class 1 integrons.	tet	0-12	dihydropteroate synthase	Escherichia coli	44-48
21747049-8	2011	Because the V1A receptor mediates cell signaling through Galpha(q) protein, we blocked Galpha(q) signaling by crossing tetracycline-transactivating factor/V1A mice with transgenic mice that expressed a small inhibitory peptide against Galpha(q).	tet	119-131	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	87-96
21747049-8	2011	Because the V1A receptor mediates cell signaling through Galpha(q) protein, we blocked Galpha(q) signaling by crossing tetracycline-transactivating factor/V1A mice with transgenic mice that expressed a small inhibitory peptide against Galpha(q).	tet	119-131	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	87-96
21747049-9	2011	Galpha(q) blockade abrogated the development of the heart failure phenotype in tetracycline-transactivating factor/V1A-TG mice.	tet	79-91	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	0-9
21718681-3	2011	By using a validated tetracycline-off-regulated CD44 expression system in the MCF-7 cell line combined with microarray analysis, we identified survivin (SVV) as a potential downstream transcriptional target of CD44.	tet	21-33	CD44 molecule (Indian blood group)	Homo sapiens	210-214
21628536-2	2011	We report a new in vitro method that measures the ability of test antibiotics azithromycin (AZM), erythromycin (ERY), tetracycline (TET), and bacitracin (BAC) to associate with mammalian cells and to protect these cells from destruction by bacteria.	tet	118-130	tetracycline-resistance protein	Staphylococcus aureus	132-135
21599854-0	2011	Interaction between the antibiotic tetracycline and the elongation factor 1alpha from the archaeon sulfolobus solfataricus.	tet	35-47	Hsp20/alpha crystallin family protein	Saccharolobus solfataricus	56-80
21599854-1	2011	The interaction between tetracycline and the archaeal elongation factor 1alpha from Sulfolobus solfataricus was investigated.	tet	24-36	Hsp20/alpha crystallin family protein	Saccharolobus solfataricus	54-78
21599854-5	2011	Tetracycline inhibits protein synthesis catalysed by elongation factor 1alpha from S. solfataricus; this is accompanied by an increase in the GDP/GTP exchange rate and a slight inhibition of the intrinsic GTPase, suggesting that a main effect of the antibiotic was exerted on the GTP-bound form of the enzyme.	tet	0-12	Hsp20/alpha crystallin family protein	Saccharolobus solfataricus	53-77
21367413-4	2011	The previous viral vector allowed for regulation of the bFGF expression by the addition of doxycycline, a tetracycline analogue.	tet	106-118	fibroblast growth factor 2	Rattus norvegicus	56-60
21120693-3	2011	Crossed with the MTB transgenic effector mouse, which targets the expression of the reverse tetracycline transactivator (rtTA) to the mammary epithelium, we demonstrate that the stabilized (and activated) form of beta-catenin (DeltaN89beta-catenin) is expressed only in the presence doxycycline-activated rtTA in the mammary epithelial compartment.	tet	92-104	catenin (cadherin associated protein), beta 1	Mus musculus	213-225
21364542-3	2011	For regulatable expression from the liver we designed a hepatospecific bidirectional and autoregulatory tetracycline (Tet)-On system (Tet(bidir)Alb) flanked by AAV inverted terminal repeats (ITRs).	tet	104-116	albumin	Mus musculus	144-147
20824710-7	2011	Reduction of Sox2 expression by using siRNA against Sox2 or by overexpressing Sox21 using a tetracycline-regulated expression system (Tet-on) caused decreased GFAP expression and a reduction in cell number due to induction of apoptosis.	tet	92-104	SRY-box transcription factor 2	Homo sapiens	13-17
20824710-7	2011	Reduction of Sox2 expression by using siRNA against Sox2 or by overexpressing Sox21 using a tetracycline-regulated expression system (Tet-on) caused decreased GFAP expression and a reduction in cell number due to induction of apoptosis.	tet	92-104	SRY-box transcription factor 21	Homo sapiens	78-83
20824710-7	2011	Reduction of Sox2 expression by using siRNA against Sox2 or by overexpressing Sox21 using a tetracycline-regulated expression system (Tet-on) caused decreased GFAP expression and a reduction in cell number due to induction of apoptosis.	tet	92-104	glial fibrillary acidic protein	Homo sapiens	159-163
21364542-3	2011	For regulatable expression from the liver we designed a hepatospecific bidirectional and autoregulatory tetracycline (Tet)-On system (Tet(bidir)Alb) flanked by AAV inverted terminal repeats (ITRs).	tet	118-121	albumin	Mus musculus	144-147
21364542-6	2011	Interestingly, the induction rate of the Tet(bidir)Alb was significantly higher than that of Tet(bidir)CMV, whereas leakage of Tet(bidir)Alb was significantly lower.	tet	41-44	albumin	Mus musculus	51-54
21420951-1	2011	Tetracycline antibiotics, including doxycycli\e (DOX), have been used to treat bone resorptive diseases, partially because of their activity to suppress osteoclastogenesis induced by receptor activator of nuclear factor kappa B ligand (RANKL).	tet	0-12	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	183-234
21524995-10	2011	As a further refinement of this approach, the engineered CD38 was placed under the control of tetracycline using an autoregulated construct.	tet	94-106	CD38 molecule	Homo sapiens	57-61
21668992-4	2011	METHODS: We generated a tetracycline-inducible FAP overexpressing fibroblastic cell line to synthesize an in vivo-like 3-dimensional (3D) matrix system which was utilized as a stromal landscape for studying matrix-induced cancer cell behaviors.	tet	24-36	fibroblast activation protein alpha	Homo sapiens	47-50
21616061-5	2011	Furthermore, in a tetracycline-induced fatty liver model, expression of FGFR4-ECD in mouse liver reduced the accumulation of hepatic lipids and partially restored the expression of peroxisome proliferator-activated receptor alpha (PPARalpha), which promotes the mitochondrial fatty acid beta-oxidation but is repressed by tetracycline.	tet	18-30	fibroblast growth factor receptor 4	Mus musculus	72-77
21616061-5	2011	Furthermore, in a tetracycline-induced fatty liver model, expression of FGFR4-ECD in mouse liver reduced the accumulation of hepatic lipids and partially restored the expression of peroxisome proliferator-activated receptor alpha (PPARalpha), which promotes the mitochondrial fatty acid beta-oxidation but is repressed by tetracycline.	tet	18-30	ecdysoneless cell cycle regulator	Mus musculus	78-81
21616061-5	2011	Furthermore, in a tetracycline-induced fatty liver model, expression of FGFR4-ECD in mouse liver reduced the accumulation of hepatic lipids and partially restored the expression of peroxisome proliferator-activated receptor alpha (PPARalpha), which promotes the mitochondrial fatty acid beta-oxidation but is repressed by tetracycline.	tet	18-30	peroxisome proliferator activated receptor alpha	Mus musculus	181-229
21616061-5	2011	Furthermore, in a tetracycline-induced fatty liver model, expression of FGFR4-ECD in mouse liver reduced the accumulation of hepatic lipids and partially restored the expression of peroxisome proliferator-activated receptor alpha (PPARalpha), which promotes the mitochondrial fatty acid beta-oxidation but is repressed by tetracycline.	tet	18-30	peroxisome proliferator activated receptor alpha	Mus musculus	231-240
21616061-5	2011	Furthermore, in a tetracycline-induced fatty liver model, expression of FGFR4-ECD in mouse liver reduced the accumulation of hepatic lipids and partially restored the expression of peroxisome proliferator-activated receptor alpha (PPARalpha), which promotes the mitochondrial fatty acid beta-oxidation but is repressed by tetracycline.	tet	322-334	fibroblast growth factor receptor 4	Mus musculus	72-77
21616061-5	2011	Furthermore, in a tetracycline-induced fatty liver model, expression of FGFR4-ECD in mouse liver reduced the accumulation of hepatic lipids and partially restored the expression of peroxisome proliferator-activated receptor alpha (PPARalpha), which promotes the mitochondrial fatty acid beta-oxidation but is repressed by tetracycline.	tet	322-334	ecdysoneless cell cycle regulator	Mus musculus	78-81
21616061-5	2011	Furthermore, in a tetracycline-induced fatty liver model, expression of FGFR4-ECD in mouse liver reduced the accumulation of hepatic lipids and partially restored the expression of peroxisome proliferator-activated receptor alpha (PPARalpha), which promotes the mitochondrial fatty acid beta-oxidation but is repressed by tetracycline.	tet	322-334	peroxisome proliferator activated receptor alpha	Mus musculus	181-229
21420951-1	2011	Tetracycline antibiotics, including doxycycli\e (DOX), have been used to treat bone resorptive diseases, partially because of their activity to suppress osteoclastogenesis induced by receptor activator of nuclear factor kappa B ligand (RANKL).	tet	0-12	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	236-241
21463634-5	2011	To inhibit cellular neddylation, we used a cell line with tetracycline-inducible expression of a dominant-negative form of the Nedd8 E2 enzyme or treatment of cells with the Nedd8 E1 inhibitor MLN4924.	tet	58-70	NEDD8 ubiquitin like modifier	Homo sapiens	127-132
21273244-5	2011	To test the ability of DYRK1A to reduce hypertrophic cardiac growth in vivo, we created tetracycline-repressible Dyrk1a transgenic mice to avoid the cardiac developmental defects associated with embryonic DYRK1A expression.	tet	88-100	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	Mus musculus	113-119
21537954-3	2011	Here, we have constructed T-REx-CHO-hAS3MTtr cells that transiently overexpress human AS3MT in response to tetracycline.	tet	107-119	arsenite methyltransferase	Homo sapiens	37-42
21070190-4	2011	INS-1 cells were stably transfected with FTO-HA (haemagluttinin) incorporated under the control of a tetracycline-inducible promoter.	tet	101-113	insulin 1	Rattus norvegicus	0-5
21471284-4	2011	Cells transfected with FLAG-tagged MCAK cDNA using a tet-off-regulated expression system had a disrupted microtubule cytoskeleton and were able to survive a toxic concentration of paclitaxel in the absence, but not in the presence of tetracycline, showing that drug resistance was caused by ectopic MCAK production.	tet	234-246	kinesin family member 2C	Homo sapiens	35-39
21129485-0	2011	Functional expression of milligram quantities of the synthetic human serotonin transporter gene in a tetracycline-inducible HEK293 cell line.	tet	101-113	solute carrier family 6 member 4	Homo sapiens	69-90
21352828-4	2011	To test this we conditionally overexpressed murine CAR in cardiomyocytes of adult binary transgenic mice under the control of a tetracycline-responsive (tet-off) alpha-myosin heavy chain (alphaMtTA) promoter (mCAR(+)/alphaMtTA(+) mice).	tet	128-140	myosin, heavy polypeptide 6, cardiac muscle, alpha	Mus musculus	162-174
21576762-4	2011	The effects on cell motility were confirmed in CHO cells with tetracycline regulated expression of beta3.	tet	62-74	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	99-104
21129436-4	2011	We established embryonic stem cells carrying tetracycline-regulated steroidogenic factor-1 gene at the ROSA26 locus.	tet	45-57	nuclear receptor subfamily 5 group A member 1	Homo sapiens	68-90
21134412-5	2011	We introduced SF-1 into mouse ES cells at ROSA26 locus under regulation of Tetracycline-off (Tet-off) in order to express SF-1 in the cells at desired period.	tet	75-87	splicing factor 1	Mus musculus	14-18
21050030-3	2011	We stably engineered a tetracycline-inducible Gal4 DNA-binding domain/RORgamma ligand-binding domain fusion protein into an upstream activation sequence driven-beta-lactamase reporter gene cell line.	tet	23-35	galectin 4	Homo sapiens	46-50
20977303-3	2011	We have constructed a conditional replication-competent adenoviral vector with TRAIL controlled by a tetracycline-inducible promoter (AdV-TRAIL).	tet	101-113	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	138-143
21327326-4	2011	In our study, we constructed a recombinant adeno-associated virus type 2 (rAAV2)-based bFGF gene delivery system, which is regulated by tetracycline or doxycycline (Dox, an analogue of tetracycline).	tet	136-148	fibroblast growth factor 2	Rattus norvegicus	87-91
21327326-4	2011	In our study, we constructed a recombinant adeno-associated virus type 2 (rAAV2)-based bFGF gene delivery system, which is regulated by tetracycline or doxycycline (Dox, an analogue of tetracycline).	tet	185-197	fibroblast growth factor 2	Rattus norvegicus	87-91
21673373-2	2011	The aim of the study was to reveal whether non-specific MMPs inhibition by tetracycline could ameliorate development of atherosclerosis in apolipoprotein E (apoE)-knockout mice.	tet	75-87	apolipoprotein E	Mus musculus	139-155
20831364-4	2011	A tetracycline regulatable system allowing repression of the endogenous essential ERG11 gene was used.	tet	2-14	sterol 14-demethylase	Saccharomyces cerevisiae S288C	82-87
21528072-0	2011	Tetracycline-inducible protein expression in pancreatic cancer cells: effects of CapG overexpression.	tet	0-12	capping actin protein, gelsolin like	Homo sapiens	81-85
21492444-6	2011	METHODS: T47-D and MCF-7 ERalpha-expressing breast cancer cells with tetracycline-regulated expression of ERbeta were used as a model system.	tet	69-81	estrogen receptor 1	Homo sapiens	25-32
21492444-6	2011	METHODS: T47-D and MCF-7 ERalpha-expressing breast cancer cells with tetracycline-regulated expression of ERbeta were used as a model system.	tet	69-81	estrogen receptor 2	Homo sapiens	106-112
20977303-3	2011	We have constructed a conditional replication-competent adenoviral vector with TRAIL controlled by a tetracycline-inducible promoter (AdV-TRAIL).	tet	101-113	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	79-84
21129485-2	2011	To investigate biophysical studies of this pharmacologically relevant transporter, we developed a mammalian expression system with tetracycline-inducible HEK293 cells using synthetic human SERT genes produced by PCR-based self-assembly method.	tet	131-143	solute carrier family 6 member 4	Homo sapiens	189-193
21378266-6	2011	Tet in the culture medium activated myc transcription and translation, allowing efficient expansion of homogeneous, clonal, karyotypically normal human CNS precursors ex vivo; in vivo, where Tet was absent, myc was not expressed, and self-renewal was entirely inactivated (as was tumorigenic potential).	tet	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	36-39
21479203-11	2011	Expression of tetracycline-inducible ALT-PTK6 blocked the proliferation and colony formation of PC3 cells.	tet	14-26	protein tyrosine kinase 6	Homo sapiens	41-45
20577802-0	2011	A new transgenic mouse line for tetracycline inducible transgene expression in mature melanocytes and the melanocyte stem cells using the Dopachrome tautomerase promoter.	tet	32-44	dopachrome tautomerase	Mus musculus	138-160
21378266-6	2011	Tet in the culture medium activated myc transcription and translation, allowing efficient expansion of homogeneous, clonal, karyotypically normal human CNS precursors ex vivo; in vivo, where Tet was absent, myc was not expressed, and self-renewal was entirely inactivated (as was tumorigenic potential).	tet	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	207-210
21142141-0	2011	Phenotypic characterization of the binding of tetracycline to human serum albumin.	tet	46-58	albumin	Homo sapiens	68-81
21189255-5	2011	Knockdown of Tbx3 expression using tetracycline-regulated Tbx3 siRNA resulted in the attenuation of ESC self-renewal ability and aberrant differentiation processes, including reduced ExEn differentiation but enhanced ectoderm and trophectoderm differentiation.	tet	35-47	T-box 3	Mus musculus	13-17
21189255-5	2011	Knockdown of Tbx3 expression using tetracycline-regulated Tbx3 siRNA resulted in the attenuation of ESC self-renewal ability and aberrant differentiation processes, including reduced ExEn differentiation but enhanced ectoderm and trophectoderm differentiation.	tet	35-47	T-box 3	Mus musculus	58-62
21341265-5	2011	Although TET-regulated MAdCAM-1 induced alpha4beta7-integrin mediated interaction of alpha4beta7(+) /alpha4beta1(-) T cells with the BBB in vitro and in vivo, it failed to influence EAE pathogenesis in C57BL/6 mice.	tet	9-12	mucosal vascular addressin cell adhesion molecule 1	Mus musculus	23-31
21341265-6	2011	TET-regulated MAdCAM-1 on the BBB neither changed the localization of central nervous system (CNS) perivascular inflammatory cuffs nor did it enhance the percentage of alpha4beta7-integrin(+) inflammatory cells within the CNS during EAE.	tet	0-3	mucosal vascular addressin cell adhesion molecule 1	Mus musculus	14-22
21281640-5	2011	We show that iron-dependent decay of tetracycline-inducible IRP2 proceeds efficiently under mild hypoxic conditions (3% oxygen) but is compromised in severe hypoxia (0.1% oxygen).	tet	37-49	iron responsive element binding protein 2	Homo sapiens	60-64
21078847-4	2011	A conditional knockdown mutant that expressed gbpB antisense RNA under the control of a tetracycline-inducible promoter was constructed in strain UA159 (UACA2) and used to investigate the effects of GbpB depletion on biofilm formation and cell surface-associated characteristics.	tet	88-100	CHAP domain-containing protein	Streptococcus mutans UA159	46-50
21036164-2	2011	The aim of this study was to investigate whether doxycycline, a tetracycline antibiotic that inhibits MMPs, attenuates mucus production and synthesis of mucin MUC5AC in acrolein-exposed rats.	tet	64-76	matrix metallopeptidase 9	Rattus norvegicus	102-106
21036164-2	2011	The aim of this study was to investigate whether doxycycline, a tetracycline antibiotic that inhibits MMPs, attenuates mucus production and synthesis of mucin MUC5AC in acrolein-exposed rats.	tet	64-76	solute carrier family 13 member 2	Rattus norvegicus	153-158
21341265-0	2011	TET inducible expression of the alpha4beta7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis.	tet	0-3	mucosal vascular addressin cell adhesion molecule 1	Mus musculus	60-68
21335597-2	2011	In the course of studying the role of hypoxia-regulated gene expression on cell survival using the tetracycline-inducible (tet-on) system, the author noted that exposure to the inducing ligand doxycycline (dox) inhibited caspase-3 cleavage in control samples.	tet	99-111	caspase 3	Homo sapiens	221-230
21116281-2	2011	To investigate this further, we developed a tetracycline-inducible mouse model of AML, in which the initial transforming event, overexpression of HOXA10, can be eliminated.	tet	44-56	homeobox A10	Mus musculus	146-152
21347410-3	2011	METHODOLOGY/PRINCIPAL FINDINGS: In this study, we generated two transgenic mice with cardiac-specific, tetracycline-suppressible expression of either Hepatocyte Growth Factor (HGF) or the constitutively activated Tpr-Met kinase to explore: i) the effect of stimulation of the endogenous Met receptor by autocrine production of HGF and ii) the consequence of sustained activation of Met signalling in the heart.	tet	103-115	hepatocyte growth factor	Mus musculus	150-174
21347410-3	2011	METHODOLOGY/PRINCIPAL FINDINGS: In this study, we generated two transgenic mice with cardiac-specific, tetracycline-suppressible expression of either Hepatocyte Growth Factor (HGF) or the constitutively activated Tpr-Met kinase to explore: i) the effect of stimulation of the endogenous Met receptor by autocrine production of HGF and ii) the consequence of sustained activation of Met signalling in the heart.	tet	103-115	hepatocyte growth factor	Mus musculus	176-179
21347410-3	2011	METHODOLOGY/PRINCIPAL FINDINGS: In this study, we generated two transgenic mice with cardiac-specific, tetracycline-suppressible expression of either Hepatocyte Growth Factor (HGF) or the constitutively activated Tpr-Met kinase to explore: i) the effect of stimulation of the endogenous Met receptor by autocrine production of HGF and ii) the consequence of sustained activation of Met signalling in the heart.	tet	103-115	translocated promoter region, nuclear basket protein	Mus musculus	213-216
21347410-3	2011	METHODOLOGY/PRINCIPAL FINDINGS: In this study, we generated two transgenic mice with cardiac-specific, tetracycline-suppressible expression of either Hepatocyte Growth Factor (HGF) or the constitutively activated Tpr-Met kinase to explore: i) the effect of stimulation of the endogenous Met receptor by autocrine production of HGF and ii) the consequence of sustained activation of Met signalling in the heart.	tet	103-115	hepatocyte growth factor	Mus musculus	327-330
21051663-5	2011	METHODS AND RESULTS: Using tetracycline-regulated expression (T-REx) inducible system expressing myocardin in human vascular SMCs, we found that overexpression of myocardin resulted in significant induction of miR-1 expression and inhibition of SMC proliferation, which was reversed by miR-1 inhibitors.	tet	27-39	myocardin	Homo sapiens	163-172
21315039-8	2011	Western blot results showed that the stable transfectants of pRevTRE2-eIF3g-microRNA inhibited eIF3g expression under the regulation of tetracycline.	tet	136-148	eukaryotic translation initiation factor 3 subunit G	Homo sapiens	70-75
21315039-8	2011	Western blot results showed that the stable transfectants of pRevTRE2-eIF3g-microRNA inhibited eIF3g expression under the regulation of tetracycline.	tet	136-148	eukaryotic translation initiation factor 3 subunit G	Homo sapiens	95-100
21315039-9	2011	CONCLUSION: The tetracycline-inducible artificial microRNA expression vector targeting eIF3g gene has been successfully constructed and effectively inhibits eIF3g expression in K562 cells.	tet	16-28	eukaryotic translation initiation factor 3 subunit G	Homo sapiens	87-92
21315039-9	2011	CONCLUSION: The tetracycline-inducible artificial microRNA expression vector targeting eIF3g gene has been successfully constructed and effectively inhibits eIF3g expression in K562 cells.	tet	16-28	eukaryotic translation initiation factor 3 subunit G	Homo sapiens	157-162
21068391-2	2011	We have studied the capacity of a small library of tetracycline analogues to modulate the formation or destructuration of beta2-microglobulin fibrils.	tet	51-63	beta-2-microglobulin	Homo sapiens	122-141
21036164-2	2011	The aim of this study was to investigate whether doxycycline, a tetracycline antibiotic that inhibits MMPs, attenuates mucus production and synthesis of mucin MUC5AC in acrolein-exposed rats.	tet	64-76	mucin 5AC, oligomeric mucus/gel-forming	Rattus norvegicus	159-165
21804222-0	2011	Binding of the highly toxic tetracycline derivative, anhydrotetracycline, to bovine serum albumin.	tet	28-40	albumin	Homo sapiens	84-97
21940270-8	2011	There were differences in tetracycline susceptibility between the VanA (70%) and the VanB (55%) phenotypes.	tet	26-38	Vancomycin Teicoplanin A-type resistance protein VanA / D-alanine--D-alanine ligase	Enterococcus faecium	66-70
21940270-8	2011	There were differences in tetracycline susceptibility between the VanA (70%) and the VanB (55%) phenotypes.	tet	26-38	D-alanine--D-lactate ligase	Enterococcus faecium	85-89
21297309-1	2011	The aim of this work was to prepare tetracycline-loaded solid lipid nanoparticles (Tet-SLN), and to evaluate the potential of these colloidal carriers for subcutaneous injection.	tet	36-48	sarcolipin	Mus musculus	87-90
21297309-3	2011	At optimized process conditions, lyophilized Tet-SLN showed spherical particles with a mean diameter of 87.2+-46.9 nm and a negative zeta potential of -6.69 mV, up to 1.7% tetracycline drug content was achieved after loading.	tet	172-184	sarcolipin	Mus musculus	49-52
21461372-0	2011	Modulation of cytokine and cytokine receptor/antagonist by treatment with doxycycline and tetracycline in patients with dengue fever.	tet	90-102	interleukin 18 receptor 1	Homo sapiens	27-44
21461372-3	2011	In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF.	tet	65-77	interleukin 6	Homo sapiens	106-110
21461372-3	2011	In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF.	tet	65-77	interleukin 1 beta	Homo sapiens	112-117
21461372-3	2011	In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF.	tet	65-77	tumor necrosis factor	Homo sapiens	123-126
21461372-3	2011	In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF.	tet	65-77	interleukin 18 receptor 1	Homo sapiens	131-148
21093486-1	2011	A study was carried out to determine whether altering the control of expression of the IE180 gene of pseudorabies virus (PRV), by replacing the IE180 promoter with the tetracycline-responsive promoter (Ptet), affects virus replication and virulence.	tet	168-180	transcriptional regulator ICP4	Suid alphaherpesvirus 1	87-92
21931765-7	2011	Using an inducible tetracycline on-off model of miR-34a expression, we show that in Daoy MB cells, Dll1 is the first target that is regulated in MB, as compared to the other targets analyzed here: Cyclin D1, cMyc and CDK4.	tet	19-31	microRNA 34a	Homo sapiens	48-55
21931765-7	2011	Using an inducible tetracycline on-off model of miR-34a expression, we show that in Daoy MB cells, Dll1 is the first target that is regulated in MB, as compared to the other targets analyzed here: Cyclin D1, cMyc and CDK4.	tet	19-31	delta like canonical Notch ligand 1	Homo sapiens	99-103
22355620-1	2011	Here we report the study of two bioengineered variants of human trace amine-associated receptor 5 (hTAAR5) that were expressed in stable tetracycline-inducible HEK293S cell lines.	tet	137-149	trace amine associated receptor 5	Homo sapiens	64-97
21853070-7	2011	The bioengineered FPR3 was overexpressed in stable tetracycline-inducible mammalian cell lines (HEK293S).	tet	51-63	formyl peptide receptor 3	Homo sapiens	18-22
21637838-2	2011	The goal of this study is to understand the molecular mechanisms underlying the phenotypic changes caused by the overexpression of ligand independent Notch 1 by using a tetracycline inducible promoter in an in vitro embryonic stem (ES) cells/OP9 stromal cells coculture system, recapitulating normal hematopoiesis.	tet	169-181	notch 1	Mus musculus	150-157
22355620-1	2011	Here we report the study of two bioengineered variants of human trace amine-associated receptor 5 (hTAAR5) that were expressed in stable tetracycline-inducible HEK293S cell lines.	tet	137-149	trace amine associated receptor 5	Homo sapiens	99-105
21135157-3	2010	In this study, we employed a tetracycline-inducible CREB repressor mouse strain, in which approximately 60% of the SCN neurons express the transgene, to test CREB functionality in the clock and its effects on overt rhythmicity.	tet	29-41	cAMP responsive element binding protein 1	Mus musculus	52-56
20338212-5	2010	In this study the mZP3 was placed under the control of the MCMV early 1 (pMCMV E1) promoter and the inducible tetracycline promoter (Tet-On).	tet	110-122	zona pellucida glycoprotein 3	Mus musculus	18-22
21042593-4	2010	Ets-1 was over-expressed using a stably-incorporated tetracycline-inducible expression vector in the ovarian cancer cell line 2008, which does not express detectable basal levels of Ets-1 protein.	tet	53-65	ETS proto-oncogene 1, transcription factor	Homo sapiens	0-5
20709688-4	2010	The resistance as to growth inhibition by reduction in Aur1p activity was also confirmed by repression of AUR1 expression under the control of a tetracycline-regulatable promoter.	tet	145-157	inositol phosphorylceramide synthase	Saccharomyces cerevisiae S288C	55-60
20709688-4	2010	The resistance as to growth inhibition by reduction in Aur1p activity was also confirmed by repression of AUR1 expression under the control of a tetracycline-regulatable promoter.	tet	145-157	inositol phosphorylceramide synthase	Saccharomyces cerevisiae S288C	106-110
21124770-5	2010	Here, we report on the study of a bioengineered zebra fish olfactory receptor OR131-2, affinity-purified from a HEK293S tetracycline-inducible system.	tet	120-132	odorant receptor, family 91, subfamily A, member 3	Danio rerio	78-85
20980052-6	2010	TRPV inhibitor ruthenium red and tetracycline-induced TRPV2 silencing significantly decreased both the frequency of Ca(2+) oscillations and the transient inward currents in RANKL-treated preosteoclasts.	tet	33-45	transient receptor potential cation channel, subfamily V, member 2	Mus musculus	54-59
20980052-6	2010	TRPV inhibitor ruthenium red and tetracycline-induced TRPV2 silencing significantly decreased both the frequency of Ca(2+) oscillations and the transient inward currents in RANKL-treated preosteoclasts.	tet	33-45	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	173-178
20682686-4	2010	RESEARCH DESIGN AND METHODS: DN-HNF1A was expressed in INS-1 cells using a reverse tetracycline-dependent transactivator system.	tet	83-95	HNF1 homeobox A	Rattus norvegicus	32-37
20695836-5	2010	MATERIAL AND METHODS: Expression of the non-structural norovirus protein p20 in the epithelial cell line HT-29/B6 was activated through a tetracycline sensitive promoter.	tet	138-150	tubulin polymerization promoting protein family member 3	Homo sapiens	73-76
20801873-3	2010	Induction of a PHD2 knockdown in tetracycline-inducible HeLa PHD2 knockdown cells resulted in increased F-actin formation as detected by phalloidin staining.	tet	33-45	egl-9 family hypoxia inducible factor 1	Homo sapiens	15-19
20801873-3	2010	Induction of a PHD2 knockdown in tetracycline-inducible HeLa PHD2 knockdown cells resulted in increased F-actin formation as detected by phalloidin staining.	tet	33-45	egl-9 family hypoxia inducible factor 1	Homo sapiens	61-65
20674683-7	2010	We describe a novel transgenic mouse model based on the tetracycline dependent inducible gene expression system in which dopamine D1-receptor transgene expression is induced selectively in neuroepithelial cells of the embryonic brain at experimenter-chosen intervals of brain development.	tet	56-68	dopamine receptor D1	Mus musculus	121-141
20976279-7	2010	To prove the temporal and regional importance of AC activity on different stages of memory processing, the tetracycline-off system was used to produce mice with forebrain-specific inducible expression of AC8 on a DKO background.	tet	107-119	adenylate cyclase 8	Mus musculus	204-207
20942963-6	2010	To titrate the expression of the fusion protein, GFP-BAX was cloned into a tetracycline sensitive expression cassette and cotransfected with a plasmid expressing the rtTA transcription factor into HCT116BAX-/- cells.	tet	75-87	BCL2 associated X, apoptosis regulator	Homo sapiens	53-56
20942967-3	2010	RESULTS: Using a lentivirus-based tetracycline-inducible shRNA approach, we show that downregulation of Ran expression in aggressive ovarian cancer cell lines affects cellular proliferation by inducing a caspase-3 associated apoptosis.	tet	34-46	RAN, member RAS oncogene family	Homo sapiens	104-107
20942967-3	2010	RESULTS: Using a lentivirus-based tetracycline-inducible shRNA approach, we show that downregulation of Ran expression in aggressive ovarian cancer cell lines affects cellular proliferation by inducing a caspase-3 associated apoptosis.	tet	34-46	caspase 3	Homo sapiens	204-213
20631244-3	2010	We have developed a tetracycline-inducible prestin-expressing cell line that we have used to model prestin"s functional maturation.	tet	20-32	solute carrier family 26 member 5	Homo sapiens	43-50
20631244-3	2010	We have developed a tetracycline-inducible prestin-expressing cell line that we have used to model prestin"s functional maturation.	tet	20-32	solute carrier family 26 member 5	Homo sapiens	99-106
20554048-6	2010	In this paper, some general considerations for the use of this approach to RNA crystallization are presented, and specifics of the application of the U1A module to the crystallization of the hairpin ribozyme and the tetracycline aptamer are reviewed.	tet	216-228	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	150-153
20700043-1	2010	To investigate the mechanism behind the pro-apoptotic ability of oncogenic H-Ras to enhance FK228-induced apoptosis, we primarily used the 10T1/2-TR-H-Ras cell line, in which ectopic expression of oncogenic H-Ras(V12) is controlled by the addition of tetracycline into cultures, and secondarily used oncogenic H-Ras-expressing MCF10A cells in our studies.	tet	251-263	HRas proto-oncogene, GTPase	Homo sapiens	75-80
20545348-7	2010	This interaction is reversibly controlled by tetracycline in a manner analogous to the interaction of TetR with its cognate DNA operator.	tet	45-57	tetracycline resistance repressor protein TetR	Escherichia coli	102-106
20919447-4	2010	Therefore, we established a human cell line expressing BMPRII tagged with a Flag epitope (BMPRII-Flag) using the tetracycline-controlled Flp-In T-REx gene expression system.	tet	113-125	bone morphogenetic protein receptor type 2	Homo sapiens	55-61
20919447-4	2010	Therefore, we established a human cell line expressing BMPRII tagged with a Flag epitope (BMPRII-Flag) using the tetracycline-controlled Flp-In T-REx gene expression system.	tet	113-125	bone morphogenetic protein receptor type 2	Homo sapiens	90-96
20919447-7	2010	Tetracycline treatment significantly increased the expression of BMPRII-Flag mRNA and protein in FT293-BMPRII cells, but induced no significant changes in expression of Id1, Id2, Id3, Smad6, or Smad7 mRNA.	tet	0-12	bone morphogenetic protein receptor type 2	Homo sapiens	65-71
20919447-7	2010	Tetracycline treatment significantly increased the expression of BMPRII-Flag mRNA and protein in FT293-BMPRII cells, but induced no significant changes in expression of Id1, Id2, Id3, Smad6, or Smad7 mRNA.	tet	0-12	bone morphogenetic protein receptor type 2	Homo sapiens	103-109
20919447-9	2010	Tetracycline-induced BMPRII-Flag expression significantly enhanced the induction of Id1, Id3, and Smad6 mRNA expression in FT293-BMPRII cells treated with BMP2.	tet	0-12	bone morphogenetic protein receptor type 2	Homo sapiens	21-27
20919447-9	2010	Tetracycline-induced BMPRII-Flag expression significantly enhanced the induction of Id1, Id3, and Smad6 mRNA expression in FT293-BMPRII cells treated with BMP2.	tet	0-12	inhibitor of DNA binding 1, HLH protein	Homo sapiens	84-87
20919447-9	2010	Tetracycline-induced BMPRII-Flag expression significantly enhanced the induction of Id1, Id3, and Smad6 mRNA expression in FT293-BMPRII cells treated with BMP2.	tet	0-12	inhibitor of DNA binding 3, HLH protein	Homo sapiens	89-92
20919447-9	2010	Tetracycline-induced BMPRII-Flag expression significantly enhanced the induction of Id1, Id3, and Smad6 mRNA expression in FT293-BMPRII cells treated with BMP2.	tet	0-12	SMAD family member 6	Homo sapiens	98-103
20919447-9	2010	Tetracycline-induced BMPRII-Flag expression significantly enhanced the induction of Id1, Id3, and Smad6 mRNA expression in FT293-BMPRII cells treated with BMP2.	tet	0-12	bone morphogenetic protein receptor type 2	Homo sapiens	129-135
20919447-9	2010	Tetracycline-induced BMPRII-Flag expression significantly enhanced the induction of Id1, Id3, and Smad6 mRNA expression in FT293-BMPRII cells treated with BMP2.	tet	0-12	bone morphogenetic protein 2	Homo sapiens	155-159
20858227-9	2010	The tet(M) gene was found in all five tetracycline-resistant vanA strains.	tet	38-50	VanA	Enterococcus faecalis	61-65
20427471-4	2010	We found that, when constructed under the control of mUPII, only a modified, reverse tetracycline trans-activator (rtTA-M2), but not its original version (rtTA), could efficiently trans-activate reporter gene expression in mouse urothelium on doxycycline (Dox) induction.	tet	85-97	uroplakin 2	Mus musculus	53-58
20831817-4	2010	In this system, expression of the lux operon is regulated by the tetracycline repressor, TetR, which is expressed from the same plasmid under the control of an arabinose-inducible promoter.	tet	65-77	tetracycline resistance repressor protein TetR	Escherichia coli	89-93
20440532-2	2010	To further investigate the melatonin"s role in IL-2/IL-2R system, we established an inducible T-REx expression system in Jurkat cells in which the protein levels of HIOMT enzyme or MT(1) receptor were significantly down-regulated upon tetracycline incubation.	tet	235-247	acetylserotonin O-methyltransferase	Homo sapiens	165-170
20440532-4	2010	Likewise, tetracycline-inducible stable cell line expressing MT(1) antisense produced decreased amounts of IL-2 (mRNA and protein levels) after stimulation.	tet	10-22	interleukin 2	Homo sapiens	107-111
20662008-4	2010	In a tetracycline-inducible stable human embryonic kidney cells (HEK293S) cell line, GABA(A) receptors containing alpha1 and beta3 subunits could be expressed with specific activities of 29-34 pmol/mg corresponding to 140-170 pmol/plate, the highest expression level reported so far.	tet	5-17	adrenoceptor alpha 1D	Homo sapiens	114-130
20815887-0	2010	Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression.	tet	0-12	gene trap ROSA 26, Philippe Soriano	Mus musculus	55-61
20815887-0	2010	Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression.	tet	0-12	immunoregulatory 2	Mus musculus	62-65
20815887-3	2010	RESULTS: To investigate whether the ubiquitously expressed Gt(ROSA)26Sor locus enables uniform DOX-controlled gene expression, we inserted the improved tetracycline-regulated transcription activator iM2 together with an iM2 dependent GFP gene into the Gt(ROSA)26Sor locus, using gene targeting to generate ROSA26-iM2-GFP (R26t1Delta) mice.	tet	152-164	gene trap ROSA 26, Philippe Soriano	Mus musculus	59-72
20558765-8	2010	Tri-DAP-induced inflammatory response in Caco2-BBE cells was significantly suppressed by silencing of PepT1 expression by using PepT1-shRNAs in a tetracycline-regulated expression (Tet-off) system.	tet	146-158	death associated protein	Homo sapiens	4-7
20558765-8	2010	Tri-DAP-induced inflammatory response in Caco2-BBE cells was significantly suppressed by silencing of PepT1 expression by using PepT1-shRNAs in a tetracycline-regulated expression (Tet-off) system.	tet	146-158	solute carrier family 15 member 1	Homo sapiens	102-107
20558765-8	2010	Tri-DAP-induced inflammatory response in Caco2-BBE cells was significantly suppressed by silencing of PepT1 expression by using PepT1-shRNAs in a tetracycline-regulated expression (Tet-off) system.	tet	146-158	solute carrier family 15 member 1	Homo sapiens	128-133
21063453-3	2010	The plasmid pUHrT62-1 encodes a tetracycline-dependant trans-activator, the protein rtTA, the plasmid pBI-SURF6--the genes of EGFP (enhanced green fluorescent protein) and of mouse SURF-6 which expression was controlled by the rtTA-responsive bi-directorial promoter.	tet	32-44	surfeit gene 6	Mus musculus	106-111
21063453-3	2010	The plasmid pUHrT62-1 encodes a tetracycline-dependant trans-activator, the protein rtTA, the plasmid pBI-SURF6--the genes of EGFP (enhanced green fluorescent protein) and of mouse SURF-6 which expression was controlled by the rtTA-responsive bi-directorial promoter.	tet	32-44	surfeit gene 6	Mus musculus	181-187
20616344-1	2010	We recently showed in a tetracycline-controlled transgenic mouse model that overexpression of transforming growth factor (TGF)-beta1 in renal tubules induces widespread peritubular fibrosis and focal degeneration of nephrons.	tet	24-36	transforming growth factor, beta 1	Mus musculus	94-132
20427471-7	2010	Finally, we established that, when combined with a Cre recombinase under the control of the tetracycline operon, the mUPII-driven rtTA-M2 could inducibly inactivate any gene of interest in mouse urothelium.	tet	92-104	uroplakin 2	Mus musculus	117-122
20428186-2	2010	To characterize the mechanisms by which AREG regulates autocrine epithelial cell growth, we transduced human keratinocytes (KCs) with lentiviral constructs expressing tetracycline (TET)-inducible small hairpin RNA (shRNA).	tet	167-179	amphiregulin	Homo sapiens	40-44
20714031-3	2010	Immunoblot method uses whole molecules of GluRepsilon2 (NR2B), which are synthesized in NIH3T3 cells by using tetracycline system as antigens.	tet	110-122	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	42-54
20714031-3	2010	Immunoblot method uses whole molecules of GluRepsilon2 (NR2B), which are synthesized in NIH3T3 cells by using tetracycline system as antigens.	tet	110-122	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	56-60
19725869-3	2010	For efficient and selective targeting of melanoma, a conditional replication-competent adenoviral vector was constructed (Ad5-FFE-02), which drives CD95L expression by a tetracycline-inducible promoter.	tet	170-182	Fas ligand	Homo sapiens	148-153
20428186-2	2010	To characterize the mechanisms by which AREG regulates autocrine epithelial cell growth, we transduced human keratinocytes (KCs) with lentiviral constructs expressing tetracycline (TET)-inducible small hairpin RNA (shRNA).	tet	181-184	amphiregulin	Homo sapiens	40-44
20428186-3	2010	TET-induced expression of AREG shRNA markedly reduced autocrine extracellular signal-regulated kinase phosphorylation, strongly inhibited autocrine KC growth with an efficiency similar to metalloproteinase and EGFR inhibitors, and induced several markers of KC differentiation, including keratins 1 and 10.	tet	0-3	amphiregulin	Homo sapiens	26-30
20428186-3	2010	TET-induced expression of AREG shRNA markedly reduced autocrine extracellular signal-regulated kinase phosphorylation, strongly inhibited autocrine KC growth with an efficiency similar to metalloproteinase and EGFR inhibitors, and induced several markers of KC differentiation, including keratins 1 and 10.	tet	0-3	epidermal growth factor receptor	Homo sapiens	210-214
20309869-0	2010	Tetracycline-regulated bone morphogenetic protein 2 gene expression in lentivirally transduced primary rabbit chondrocytes for treatment of cartilage defects.	tet	0-12	bone morphogenetic protein 2	Oryctolagus cuniculus	23-51
19921696-4	2010	In this study, a tetracycline-inducible expression vector, pETE-Bsd, was used to obtain stable transfectants of THY1.	tet	17-29	Thy-1 cell surface antigen	Homo sapiens	112-116
19921696-5	2010	The stringent in vivo tumorigenicity assay results show that the activation of THY1 suppresses tumor formation of HONE1 cells in nude mice, and the tumor formation ability was restored in the presence of doxycycline (a tetracycline analog), when the gene is shut off.	tet	219-231	Thy-1 cell surface antigen	Homo sapiens	79-83
20309869-3	2010	This study was undertaken to construct an efficient tetracycline (Tet)-regulated, lentivirally mediated system for the expression of growth factor bone morphogenetic protein 2 (BMP-2) in primary rabbit chondrocytes that will allow for the induction and termination of growth factor gene expression once cartilage regeneration is complete.	tet	52-64	bone morphogenetic protein 2	Oryctolagus cuniculus	147-175
20309869-3	2010	This study was undertaken to construct an efficient tetracycline (Tet)-regulated, lentivirally mediated system for the expression of growth factor bone morphogenetic protein 2 (BMP-2) in primary rabbit chondrocytes that will allow for the induction and termination of growth factor gene expression once cartilage regeneration is complete.	tet	52-64	bone morphogenetic protein 2	Oryctolagus cuniculus	177-182
20309869-3	2010	This study was undertaken to construct an efficient tetracycline (Tet)-regulated, lentivirally mediated system for the expression of growth factor bone morphogenetic protein 2 (BMP-2) in primary rabbit chondrocytes that will allow for the induction and termination of growth factor gene expression once cartilage regeneration is complete.	tet	66-69	bone morphogenetic protein 2	Oryctolagus cuniculus	147-175
20309869-3	2010	This study was undertaken to construct an efficient tetracycline (Tet)-regulated, lentivirally mediated system for the expression of growth factor bone morphogenetic protein 2 (BMP-2) in primary rabbit chondrocytes that will allow for the induction and termination of growth factor gene expression once cartilage regeneration is complete.	tet	66-69	bone morphogenetic protein 2	Oryctolagus cuniculus	177-182
20309869-7	2010	An up to 20-fold induction of Tet-mediated BMP-2 expression was observed on ATDC5 cells.	tet	30-33	bone morphogenetic protein 2	Mus musculus	43-48
20309869-11	2010	CONCLUSION: The lentivirally mediated Tet-On system is an effective strategy for efficient, repeatedly inducible expression of BMP-2 in primary rabbit chondrocytes.	tet	38-41	bone morphogenetic protein 2	Oryctolagus cuniculus	127-132
21779459-3	2010	Furthermore, activation of conditional alleles of Myc, either tetracycline or estrogen inducible, upregulates expression of a large number of genes, both in tissue culture and in transgenic animals.	tet	62-74	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	50-53
20375852-2	2010	To achieve temporal overexpression of respiratory epithelium-specific FasL expression, tetracycline inducible CCSP-rtTA/FasL-TetOp transgenic mice were given doxycycline (Dox) from gestational d 14 (E14) to E19 (antenatal treatment group), from postnatal d 1 (P1) to P7 (postnatal group), or from E14 to P7 (combined antenatal and postnatal group).	tet	87-99	Fas ligand (TNF superfamily, member 6)	Mus musculus	120-124
20069635-3	2010	In vitro activity of aggrecanase-1 and -2 was recorded in the presence of 1-100 microM tetracycline, minocycline, or doxycyline.	tet	87-99	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	21-41
20339854-4	2010	METHODS: An EphB2-negative colon cancer cell line (LIM2405) was transfected with a full-length EphB2 cDNA in a vector designed to respond to the drug tetracycline.	tet	150-162	Eph receptor B2	Mus musculus	12-17
20339854-4	2010	METHODS: An EphB2-negative colon cancer cell line (LIM2405) was transfected with a full-length EphB2 cDNA in a vector designed to respond to the drug tetracycline.	tet	150-162	Eph receptor B2	Mus musculus	95-100
20069635-4	2010	Human knee articular cartilage explants were sorted according to the degree of OA and treated for 10 days with tetracycline derivatives in the presence of interleukin-1 (IL-1beta).	tet	111-123	interleukin 1 alpha	Homo sapiens	155-168
20497571-3	2010	RESULTS: Tetracycline-regulated expression of CTGF/CCN2 in HC11 cells enhanced multiple markers of lactogenic differentiation including beta-casein transcription and mammosphere formation.	tet	9-21	cellular communication network factor 2	Homo sapiens	46-50
20069635-4	2010	Human knee articular cartilage explants were sorted according to the degree of OA and treated for 10 days with tetracycline derivatives in the presence of interleukin-1 (IL-1beta).	tet	111-123	interleukin 1 beta	Homo sapiens	170-178
19795218-0	2010	Tetracycline-dependent expression of the human erythropoietin gene in transgenic chickens.	tet	0-12	erythropoietin	Homo sapiens	47-61
19795218-2	2010	In this study, we report successful production of transgenic chickens that express the human erythropoietin (hEPO) gene under the control of a tetracycline-inducible promoter.	tet	143-155	erythropoietin	Homo sapiens	93-107
19795218-2	2010	In this study, we report successful production of transgenic chickens that express the human erythropoietin (hEPO) gene under the control of a tetracycline-inducible promoter.	tet	143-155	erythropoietin	Homo sapiens	109-113
19795218-4	2010	Out of 198 injected eggs, 15 chicks hatched after 21 days of incubation and 14 hatched chicks expressed the vector-encoded hEPO gene when fed doxycycline, a tetracycline derivative, without any significant physiological dysfunctions.	tet	157-169	erythropoietin	Homo sapiens	123-127
19795218-8	2010	Tetracycline-inducible expression of the hEPO gene was also confirmed in the blood and eggs of the transgenic chickens.	tet	0-12	erythropoietin	Homo sapiens	41-45
19821046-2	2010	The transgene was constructed in a way that a CMV enhancer linked to the chicken beta-actin promoter (CAG) drives the expression of the tetracycline-controlled transactivator (tTA) in particular tissues upon Cre-mediated excision of a floxed betageo marker located between the promoter and the tTA.	tet	136-148	actin, beta	Gallus gallus	81-91
20197375-2	2010	We describe a fluorescence-based assay that measures NMDA receptor-mediated changes in intracellular calcium in a BHK-21 cell line stably expressing NMDA receptor NR2D with NR1 under the control of a tetracycline-inducible promoter (Tet-On).	tet	200-212	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	53-66
20197375-2	2010	We describe a fluorescence-based assay that measures NMDA receptor-mediated changes in intracellular calcium in a BHK-21 cell line stably expressing NMDA receptor NR2D with NR1 under the control of a tetracycline-inducible promoter (Tet-On).	tet	200-212	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	149-162
20197375-2	2010	We describe a fluorescence-based assay that measures NMDA receptor-mediated changes in intracellular calcium in a BHK-21 cell line stably expressing NMDA receptor NR2D with NR1 under the control of a tetracycline-inducible promoter (Tet-On).	tet	200-212	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	173-176
20497571-3	2010	RESULTS: Tetracycline-regulated expression of CTGF/CCN2 in HC11 cells enhanced multiple markers of lactogenic differentiation including beta-casein transcription and mammosphere formation.	tet	9-21	cellular communication network factor 2	Homo sapiens	51-55
20220142-3	2010	Using stable HeLa transfectant clones with the tetracycline-inducible CAGE gene, we found that CAGE overexpression stimulated both anchorage-dependent and -independent cell growth in vitro and promoted tumor growth in a xenograft mouse model.	tet	47-59	DEAD-box helicase 53	Homo sapiens	70-74
20223922-2	2010	We report here the development of novel conditional mouse models for ALK-induced lymphomagenesis, with the use of the tetracycline regulatory system under the control of the EmuSRalpha enhancer/promoter.	tet	118-130	anaplastic lymphoma kinase	Mus musculus	69-72
19914010-13	2010	All t127, ST1 isolates were resistant to tetracycline-ciprofloxacin-erythromycin.	tet	41-53	syndecan binding protein	Homo sapiens	10-13
20220142-3	2010	Using stable HeLa transfectant clones with the tetracycline-inducible CAGE gene, we found that CAGE overexpression stimulated both anchorage-dependent and -independent cell growth in vitro and promoted tumor growth in a xenograft mouse model.	tet	47-59	DEAD-box helicase 53	Homo sapiens	95-99
20178833-2	2010	To determine whether mitochondrial impairment plays a role in the accumulation of alpha-Syn oligomer, we used 3D5 cell culture model of human neuronal type whereby conditional overexpression of wild-type alpha-Syn via the tetracycline-off (TetOff) induction mechanism results in formation of inclusions that exhibit many characteristics of Lewy bodies.	tet	222-234	synuclein alpha	Homo sapiens	204-213
20372814-5	2010	In this study, we established a mouse L cell line transformed with tetracycline-induced rcas1 gene expression system and analyzed the RCAS1 functions.	tet	67-79	estrogen receptor-binding fragment-associated gene 9	Mus musculus	88-93
20372814-5	2010	In this study, we established a mouse L cell line transformed with tetracycline-induced rcas1 gene expression system and analyzed the RCAS1 functions.	tet	67-79	estrogen receptor-binding fragment-associated gene 9	Mus musculus	134-139
19595472-3	2010	The LTBDH/PGR gene was expressed in lung cancer cell lines through recombinant adenovirus infection, and through a tetracycline-inducible expression system.	tet	115-127	progesterone receptor	Homo sapiens	10-13
20405006-5	2010	Human H1299 lung cancer cells or clones engineered for tetracycline-inducible expression of wild type IRP2, or the deletion mutant IRP2(Delta73) (lacking a specific insert of 73 amino acids), were injected subcutaneously into nude mice.	tet	55-67	iron responsive element binding protein 2	Homo sapiens	102-106
20405006-6	2010	The induction of IRP2 profoundly stimulated the growth of tumor xenografts, and this response was blunted by addition of tetracycline in the drinking water of the animals, to turnoff the IRP2 transgene.	tet	121-133	iron responsive element binding protein 2	Homo sapiens	17-21
20405006-6	2010	The induction of IRP2 profoundly stimulated the growth of tumor xenografts, and this response was blunted by addition of tetracycline in the drinking water of the animals, to turnoff the IRP2 transgene.	tet	121-133	iron responsive element binding protein 2	Homo sapiens	187-191
20405018-5	2010	Expression of XHSF380, a dominant-negative HSF1 mutant, was embryonic lethal, which could be circumvented by delaying expression via a tetracycline inducible promoter.	tet	135-147	heat shock factor protein	Xenopus laevis	43-47
20374640-7	2010	Resistance genes included dfr, TEM beta-lactamase, tet and cat, conferring resistance to trimethoprim, ampicillin, tetracycline and chloramphenicol, respectively.	tet	115-127	blaTEM	Escherichia coli	31-49
20131247-7	2010	A tetracycline-inducible system in T-Rex 293 cells was used to induce Fox-2 protein, and endogenous LH2(long) mRNA was determined by reverse transcriptase-polymerase chain reaction.	tet	2-14	RNA binding fox-1 homolog 2	Homo sapiens	70-75
20181654-0	2010	Tetracycline-mediated IgE isotype-specific suppression of ongoing human and murine IgE responses in vivo and murine memory IgE responses induced in vitro.	tet	0-12	immunoglobulin heavy constant epsilon	Homo sapiens	22-25
19940262-1	2010	We recently described a murine embryonic stem cell (ESC) line engineered to express the activated Notch 4 receptor in a tetracycline (doxcycline; Dox) regulated fashion (tet-notch4 ESCs).	tet	120-132	notch 4	Mus musculus	98-105
20181654-0	2010	Tetracycline-mediated IgE isotype-specific suppression of ongoing human and murine IgE responses in vivo and murine memory IgE responses induced in vitro.	tet	0-12	immunoglobulin heavy constant epsilon	Homo sapiens	83-86
20181654-0	2010	Tetracycline-mediated IgE isotype-specific suppression of ongoing human and murine IgE responses in vivo and murine memory IgE responses induced in vitro.	tet	0-12	immunoglobulin heavy constant epsilon	Homo sapiens	83-86
20181654-9	2010	Tetracycline suppression of all human and murine IgE responses was IgE isotype specific.	tet	0-12	immunoglobulin heavy constant epsilon	Homo sapiens	49-52
20181654-9	2010	Tetracycline suppression of all human and murine IgE responses was IgE isotype specific.	tet	0-12	immunoglobulin heavy constant epsilon	Homo sapiens	67-70
20214788-9	2010	Towards this end, we generated a tetracycline inducible transgenic mouse expressing JDP2 specifically in the liver.	tet	33-45	Jun dimerization protein 2	Mus musculus	84-88
20071742-7	2010	We demonstrate the application of this strategy through the creation of a tetracycline-inducible reporter system at the HPRT locus.	tet	74-86	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	120-124
20332428-1	2010	To investigate the temporal regulation of the commitment of immature thymocytes to either the CD4(+) or the CD8(+) lineage in the thymus, we developed a transgenic mouse that expressed a tetracycline-inducible gene encoding the tyrosine kinase zeta chain-associated protein kinase of 70 kD (Zap70), which restored development in Zap70(-/-) thymocytes arrested at the preselection, CD4(+)CD8(+) double-positive (DP) stage.	tet	187-199	CD4 antigen	Mus musculus	94-97
20332428-1	2010	To investigate the temporal regulation of the commitment of immature thymocytes to either the CD4(+) or the CD8(+) lineage in the thymus, we developed a transgenic mouse that expressed a tetracycline-inducible gene encoding the tyrosine kinase zeta chain-associated protein kinase of 70 kD (Zap70), which restored development in Zap70(-/-) thymocytes arrested at the preselection, CD4(+)CD8(+) double-positive (DP) stage.	tet	187-199	zeta-chain (TCR) associated protein kinase	Mus musculus	291-296
20332428-1	2010	To investigate the temporal regulation of the commitment of immature thymocytes to either the CD4(+) or the CD8(+) lineage in the thymus, we developed a transgenic mouse that expressed a tetracycline-inducible gene encoding the tyrosine kinase zeta chain-associated protein kinase of 70 kD (Zap70), which restored development in Zap70(-/-) thymocytes arrested at the preselection, CD4(+)CD8(+) double-positive (DP) stage.	tet	187-199	zeta-chain (TCR) associated protein kinase	Mus musculus	329-334
20332428-1	2010	To investigate the temporal regulation of the commitment of immature thymocytes to either the CD4(+) or the CD8(+) lineage in the thymus, we developed a transgenic mouse that expressed a tetracycline-inducible gene encoding the tyrosine kinase zeta chain-associated protein kinase of 70 kD (Zap70), which restored development in Zap70(-/-) thymocytes arrested at the preselection, CD4(+)CD8(+) double-positive (DP) stage.	tet	187-199	CD4 antigen	Mus musculus	381-384
20051426-8	2010	Using tetracycline-inducible CUGBP1 and heart-specific reverse tetracycline trans-activator transgenes, we expressed human CUGBP1 in adult mouse heart.	tet	6-18	CUGBP Elav-like family member 1	Homo sapiens	29-35
20051426-8	2010	Using tetracycline-inducible CUGBP1 and heart-specific reverse tetracycline trans-activator transgenes, we expressed human CUGBP1 in adult mouse heart.	tet	6-18	CUGBP Elav-like family member 1	Homo sapiens	123-129
20051426-8	2010	Using tetracycline-inducible CUGBP1 and heart-specific reverse tetracycline trans-activator transgenes, we expressed human CUGBP1 in adult mouse heart.	tet	63-75	CUGBP Elav-like family member 1	Homo sapiens	123-129
20164342-5	2010	To evaluate the temporal and spatial specificity of the effect of early-life CRH exposure on adult behavior, the tetracycline-off system was used to produce mice with forebrain-restricted inducible expression of CRH.	tet	113-125	corticotropin releasing hormone	Mus musculus	212-215
20051518-6	2010	Tetracycline-regulated Noxa expression did not trigger cell death per se but sensitized to bortezomib treatment in a dose-dependent manner.	tet	0-12	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	23-27
20089521-6	2010	Lentivirus-mediated expression of recombinant human prostasin under tetracycline regulation was performed to obtain stable B6Tert-1 cell sublines that over-expressed prostasin.	tet	68-80	serine protease 8	Homo sapiens	52-61
20200944-5	2010	To further investigate how activation of the G(s)-GPCR pathway affects bone formation at different ages, we used the tetracycline-inducible system in the ColI(2.3)(+)/Rs1(+) mouse model to control the timing of Rs1 expression.	tet	117-129	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	167-170
20200944-5	2010	To further investigate how activation of the G(s)-GPCR pathway affects bone formation at different ages, we used the tetracycline-inducible system in the ColI(2.3)(+)/Rs1(+) mouse model to control the timing of Rs1 expression.	tet	117-129	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	211-214
20161711-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: Here we demonstrate that tetracycline-regulated expression of the canonical Wnt inhibitor DKK1 in TECs localized in both the cortex and medulla of adult mice, results in rapid thymic degeneration characterized by a loss of DeltaNP63(+) Foxn1(+) and Aire(+) TECs, loss of K5K8DP TECs thought to represent or contain an immature TEC progenitor, decreased TEC proliferation and the development of cystic structures, similar to an aged thymus.	tet	57-69	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	122-126
20161783-15	2010	In addition, tetracycline-regulated optineurin-GFPs expressing RGC5 stable cell lines were established for the first time.	tet	13-25	optineurin	Mus musculus	36-46
20161711-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: Here we demonstrate that tetracycline-regulated expression of the canonical Wnt inhibitor DKK1 in TECs localized in both the cortex and medulla of adult mice, results in rapid thymic degeneration characterized by a loss of DeltaNP63(+) Foxn1(+) and Aire(+) TECs, loss of K5K8DP TECs thought to represent or contain an immature TEC progenitor, decreased TEC proliferation and the development of cystic structures, similar to an aged thymus.	tet	57-69	forkhead box N1	Mus musculus	268-273
20332492-3	2010	To identify global mRNA expression patterns that are potentially regulated by YB-1, a previously established and well-characterized cell model derived from drug-sensitive (EPG85-257P/tetR/YB-1) and multidrug-resistant (EPG85-257RDB/tetR/YB-1) gastric carcinoma cells in which the expression of YB-1 can be inhibited by tetracycline-dependent activation of the RNA interference (RNAi) pathway, was analyzed by microarray technology.	tet	319-331	Y-box binding protein 1	Homo sapiens	78-82
19933399-4	2010	Using a tetracycline-repressible system, we expressed constitutively active Notch4 (Notch4*) specifically in the endothelium of adult mice.	tet	8-20	notch 4	Mus musculus	76-82
19933399-4	2010	Using a tetracycline-repressible system, we expressed constitutively active Notch4 (Notch4*) specifically in the endothelium of adult mice.	tet	8-20	notch 4	Mus musculus	84-90
19997864-1	2010	The potential of Lactobacillus reuteri as a donor of antibiotic resistance genes in the human gut was investigated by studying the transferability of the tetracycline resistance gene tet(W) to faecal enterococci, bifidobacteria and lactobacilli.	tet	154-166	tetracycline resistance protein	Lactobacillus reuteri	183-189
20193129-2	2010	In this study, we attempted to efficiently identify false positives by introducing a tetracycline operator (tetO) motif into the RPR1 promoter of an RNA hybrid expression vector.	tet	85-97	RPR1	Saccharomyces cerevisiae S288C	129-133
20193129-3	2010	We successfully developed a tight tetracycline-regulatable RPR1 promoter variant containing a single tetO motif between the transcription start site and the A-box sequence of the RPR1 promoter.	tet	34-46	RPR1	Saccharomyces cerevisiae S288C	59-63
20193129-3	2010	We successfully developed a tight tetracycline-regulatable RPR1 promoter variant containing a single tetO motif between the transcription start site and the A-box sequence of the RPR1 promoter.	tet	34-46	RPR1	Saccharomyces cerevisiae S288C	179-183
20193129-4	2010	Expression from this tetracycline-regulatable RPR1 promoter in the presence of tetracycline-response transcription activator (tTA) was positively controlled by doxycycline (Dox), a derivative of tetracycline.	tet	21-33	RPR1	Saccharomyces cerevisiae S288C	46-50
20193129-4	2010	Expression from this tetracycline-regulatable RPR1 promoter in the presence of tetracycline-response transcription activator (tTA) was positively controlled by doxycycline (Dox), a derivative of tetracycline.	tet	79-91	RPR1	Saccharomyces cerevisiae S288C	46-50
20193129-4	2010	Expression from this tetracycline-regulatable RPR1 promoter in the presence of tetracycline-response transcription activator (tTA) was positively controlled by doxycycline (Dox), a derivative of tetracycline.	tet	79-91	RPR1	Saccharomyces cerevisiae S288C	46-50
20067638-5	2010	METHODS: Under the control of a tetracycline regulatable promoter, dominant negative mutants of Rac1 and Cdc42 were expressed in a human HRas-transformed, tumor derived fibroblast cell line.	tet	32-44	cell division cycle 42	Homo sapiens	105-110
20067638-5	2010	METHODS: Under the control of a tetracycline regulatable promoter, dominant negative mutants of Rac1 and Cdc42 were expressed in a human HRas-transformed, tumor derived fibroblast cell line.	tet	32-44	HRas proto-oncogene, GTPase	Homo sapiens	137-141
20067638-5	2010	METHODS: Under the control of a tetracycline regulatable promoter, dominant negative mutants of Rac1 and Cdc42 were expressed in a human HRas-transformed, tumor derived fibroblast cell line.	tet	32-44	Rac family small GTPase 1	Homo sapiens	96-100
19721064-2	2009	The multidrug susceptibility phenotype (e.g., to tetracycline and beta-lactam antibiotics) required the inactivation of both lon and ycgE.	tet	49-61	putative ATP-dependent Lon protease	Escherichia coli	125-128
19817749-5	2010	Evidence for an etoposide-specific resistance, which develops as a consequence of inhibiting the PHD activity, was further supported in a tetracycline-inducible PHD2 knockdown HeLa cell model.	tet	138-150	egl-9 family hypoxia inducible factor 1	Homo sapiens	161-165
19794060-0	2010	Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice.	tet	0-12	islet amyloid polypeptide	Homo sapiens	88-94
19794060-2	2010	Here, we used tetracycline, which modifies hA/hIAPP oligomerization, to probe mechanisms whereby hA/hIAPP causes diabetes in hemizygous hA/hIAPP-transgenic mice.	tet	14-26	islet amyloid polypeptide	Homo sapiens	46-51
19794060-2	2010	Here, we used tetracycline, which modifies hA/hIAPP oligomerization, to probe mechanisms whereby hA/hIAPP causes diabetes in hemizygous hA/hIAPP-transgenic mice.	tet	14-26	islet amyloid polypeptide	Homo sapiens	100-105
19794060-2	2010	Here, we used tetracycline, which modifies hA/hIAPP oligomerization, to probe mechanisms whereby hA/hIAPP causes diabetes in hemizygous hA/hIAPP-transgenic mice.	tet	14-26	islet amyloid polypeptide	Homo sapiens	100-105
20699604-0	2010	Developing a system for regulating expression of human hepatocyte growth factor using tetracycline in NRK52E cells.	tet	86-98	hepatocyte growth factor	Homo sapiens	55-79
20699604-2	2010	The aim of this study was to establish a human HGF gene expression system that is regulated by tetracycline (Tet) in normal rat kidney tubular epithelial cells (NRK52E cells).	tet	95-107	hepatocyte growth factor	Homo sapiens	47-50
20699604-2	2010	The aim of this study was to establish a human HGF gene expression system that is regulated by tetracycline (Tet) in normal rat kidney tubular epithelial cells (NRK52E cells).	tet	109-112	hepatocyte growth factor	Homo sapiens	47-50
20699604-8	2010	CONCLUSIONS: A Tet-regulated human HGF gene expression system in NRK52E cells has been established.	tet	15-18	hepatocyte growth factor	Homo sapiens	35-38
20514206-3	2009	Recently, many drugs, such as tetracycline derivatives, cyclooxygenase inhibitors, ACEI inhibitors and AT1 receptor blockers, etc., have been found to attenuate the elevated expression levels of MMP-9 after ischemia and to reduce the damage of cerebral ischemic.	tet	30-42	matrix metallopeptidase 9	Homo sapiens	195-200
20161659-5	2009	We identified a tetracycline-like compound, PTK-SMA1, which stimulates exon 7 splicing and increases SMN protein levels in vitro and in vivo in mice.	tet	16-28	survival motor neuron 1	Mus musculus	101-104
19808649-4	2009	We then produced recombinant adenoviruses Ad.TRE-uPA, in which the urokinase was located downstream of the tetracycline response element (TRE).	tet	107-119	plasminogen activator, urokinase	Mus musculus	49-52
20238019-2	2010	In an effort to establish an inducible gene knockout system for the RPE, we recently used a 3.0-kb human VMD2 promoter to direct the expression of a reverse tetracycline-inducible system controlled Cre recombinase in transgenic mice.	tet	157-169	bestrophin 1	Homo sapiens	105-109
20860838-4	2010	METHODS: Tetracycline-regulatable p190B transgenic mice were bred to MMTV-Neu mice, and the effects of exogenous p190B expression on tumor latency, multiplicity, growth rates, angiogenesis, and metastasis were examined.	tet	9-21	Rho GTPase activating protein 5	Mus musculus	34-39
21072319-3	2010	Using a tetracycline-inducible system, we found that overexpression of EIG121, but not of LacZ, caused a profound suppression of cell growth.	tet	8-20	endosome-lysosome associated apoptosis and autophagy regulator 1	Homo sapiens	71-77
19653308-5	2010	We have developed mouse transgenic systems to manipulate gene activity in the Wnt1-expressing precursors and their derivatives by integrating the tetracycline-dependent activation and Cre-mediated recombination methods.	tet	146-158	wingless-type MMTV integration site family, member 1	Mus musculus	78-82
19769966-3	2010	To facilitate analyses of this gene, which is toxic to cells at low levels, we obtained stable clones of HeLa cells expressing a tetracycline-induced MORF4 construct that could be induced by doxycycline in a dose-dependent manner.	tet	129-141	mortality factor 4 (pseudogene)	Homo sapiens	150-155
19835916-5	2010	Therefore, this study established PC12 cell lines which overexpress human alpha-synuclein in a tetracycline-inducible manner.	tet	95-107	synuclein alpha	Homo sapiens	74-89
19824060-5	2009	Down-regulation of FGF2 production by tetracycline administration and/or of VEGF production by AS-VEGF transduction inhibited tumour growth and vascularization, with profound changes in tumour micro-environment.	tet	38-50	fibroblast growth factor 2	Homo sapiens	19-23
19748481-3	2009	We previously established tetracycline-regulated human cell line that can be induced to express PPARalpha and found that PPARalpha induces the SLC25A20 expression.	tet	26-38	peroxisome proliferator activated receptor alpha	Homo sapiens	96-105
19748481-3	2009	We previously established tetracycline-regulated human cell line that can be induced to express PPARalpha and found that PPARalpha induces the SLC25A20 expression.	tet	26-38	peroxisome proliferator activated receptor alpha	Homo sapiens	121-130
19748481-3	2009	We previously established tetracycline-regulated human cell line that can be induced to express PPARalpha and found that PPARalpha induces the SLC25A20 expression.	tet	26-38	solute carrier family 25 member 20	Homo sapiens	143-151
19657147-2	2009	Using TG2 transfected Swiss 3T3 fibroblasts expressing TG2 under the control of the tetracycline-regulated inducible promoter, we demonstrate that induction of TG2 not only stimulates an increase in collagen and fibronectin deposition but also an increase in the expression of these proteins.	tet	84-96	fibronectin 1	Homo sapiens	212-223
19762713-6	2009	In this study, we achieved robust expression of human mutant (MT) or wild-type (WT) COMP in mice by using a tetracycline-inducible promoter.	tet	108-120	cartilage oligomeric matrix protein	Homo sapiens	84-88
19835622-3	2009	FINDINGS: To solve these problems, we developed two different approaches to improve our pancreatic beta-cell line INS-1 Flp-In T-REx expressing the tissue restricted transcription factor HNF4alpha under control of tetracycline.	tet	214-226	forkhead box M1	Homo sapiens	114-119
19835622-3	2009	FINDINGS: To solve these problems, we developed two different approaches to improve our pancreatic beta-cell line INS-1 Flp-In T-REx expressing the tissue restricted transcription factor HNF4alpha under control of tetracycline.	tet	214-226	hepatocyte nuclear factor 4 alpha	Homo sapiens	187-196
19666776-1	2009	The proenzyme single-chain urokinase plasminogen activator (scuPA) more effectively resolved intrapleural loculations in rabbits with tetracycline (TCN)-induced loculation than a range of clinical doses of two-chain uPA (Abbokinase) and demonstrated a trend toward greater efficacy than single-chain tPA (Activase) (Idell S et al., Exp Lung Res 33: 419, 2007.).	tet	134-146	urokinase-type plasminogen activator	Oryctolagus cuniculus	62-65
19666776-1	2009	The proenzyme single-chain urokinase plasminogen activator (scuPA) more effectively resolved intrapleural loculations in rabbits with tetracycline (TCN)-induced loculation than a range of clinical doses of two-chain uPA (Abbokinase) and demonstrated a trend toward greater efficacy than single-chain tPA (Activase) (Idell S et al., Exp Lung Res 33: 419, 2007.).	tet	148-151	urokinase-type plasminogen activator	Oryctolagus cuniculus	62-65
19666776-10	2009	These complexes promote uPA-mediated plasminogen activation in scuPA-treated rabbits with TCN-induced pleural injury.	tet	90-93	urokinase-type plasminogen activator	Oryctolagus cuniculus	24-27
19363467-5	2009	In addition, to confirm the specificity of Ad-Delo3-RGD for YB-1 a tetracycline-inducible anti-YB-1 shRNA-expressing cell variant EPG85-257RDB/tetR/YB-1 was used.	tet	67-79	Y-box binding protein 1	Homo sapiens	60-64
19363467-5	2009	In addition, to confirm the specificity of Ad-Delo3-RGD for YB-1 a tetracycline-inducible anti-YB-1 shRNA-expressing cell variant EPG85-257RDB/tetR/YB-1 was used.	tet	67-79	Y-box binding protein 1	Homo sapiens	95-99
19363467-5	2009	In addition, to confirm the specificity of Ad-Delo3-RGD for YB-1 a tetracycline-inducible anti-YB-1 shRNA-expressing cell variant EPG85-257RDB/tetR/YB-1 was used.	tet	67-79	Y-box binding protein 1	Homo sapiens	95-99
19605700-5	2009	In the present study, we expressed EVI1 and MDS1/EVI1 in a tetracycline-regulable manner in the human myeloid cell line U937.	tet	59-71	MDS1 and EVI1 complex locus	Homo sapiens	35-39
19639608-4	2009	METHODS: A tetracycline-inducible adeno-associated virus (AAV)-1 vector expressing human GDNF cDNA was administered unilaterally in the rat striatum 5 weeks after 6-hydroxydopamine.	tet	11-23	glial cell derived neurotrophic factor	Homo sapiens	89-93
19637229-3	2009	Using a tetracycline inducible eukaryotic system, we were able to express recombinant TDO protein, which exhibits functional properties of native TDO.	tet	8-20	tryptophan 2,3-dioxygenase	Homo sapiens	86-89
19637229-3	2009	Using a tetracycline inducible eukaryotic system, we were able to express recombinant TDO protein, which exhibits functional properties of native TDO.	tet	8-20	tryptophan 2,3-dioxygenase	Homo sapiens	146-149
19747349-4	2009	Furthermore, tetracycline-regulated induction of Foxo3, another member of the Foxo subfamily, into Foxo1-null endothelial cells failed to restore abnormal morphological response to VEGF-A at an early differentiation stage.	tet	13-25	forkhead box O3	Mus musculus	49-54
19747349-4	2009	Furthermore, tetracycline-regulated induction of Foxo3, another member of the Foxo subfamily, into Foxo1-null endothelial cells failed to restore abnormal morphological response to VEGF-A at an early differentiation stage.	tet	13-25	forkhead box O1	Mus musculus	49-53
19747349-4	2009	Furthermore, tetracycline-regulated induction of Foxo3, another member of the Foxo subfamily, into Foxo1-null endothelial cells failed to restore abnormal morphological response to VEGF-A at an early differentiation stage.	tet	13-25	forkhead box O1	Mus musculus	99-104
19605700-5	2009	In the present study, we expressed EVI1 and MDS1/EVI1 in a tetracycline-regulable manner in the human myeloid cell line U937.	tet	59-71	MDS1 and EVI1 complex locus	Homo sapiens	44-48
19605700-5	2009	In the present study, we expressed EVI1 and MDS1/EVI1 in a tetracycline-regulable manner in the human myeloid cell line U937.	tet	59-71	MDS1 and EVI1 complex locus	Homo sapiens	49-53
19523467-4	2009	The induced expression of PKCeta in MCF-7 cells, under the control of the tetracycline-responsive promoter, resulted in increased cell survival and inhibition of cleavage of the apoptotic marker PARP-1.	tet	74-86	poly(ADP-ribose) polymerase 1	Homo sapiens	195-201
19639960-4	2009	We used a clone of H358, stably transfected with a tetracycline-inducible wild-type p53-expressing vector.	tet	51-63	tumor protein p53	Homo sapiens	84-87
19663997-8	2009	Culture of such transfected cells in the absence of tetracycline led to a 2.5-fold activation of the C/EBPalpha promoter.	tet	52-64	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	101-111
19675065-7	2009	Finally, expression of the Kif5bDN prior to induction of Kv1.5 in a tetracycline inducible system blocked surface expression of the channel in both HEK293 cells and H9c2 cardiomyoblasts.	tet	68-80	potassium voltage-gated channel subfamily A member 5	Homo sapiens	57-62
19728780-3	2009	The bla(TEM-52)-containing isolate showed a phenotype of multiresistance that included fluoroquinolones, tetracycline, trimethoprim-sulfamethoxazole, and chloramphenicol; sul1, sul3, and cmlA genes were detected in this isolate, in addition to two amino acid changes in GyrA (Ser83Leu + Asp87Asn) and one in ParC protein (Ser80Ile).	tet	105-117	TEM-52	Escherichia coli	8-14
19444492-5	2009	Nine were resistant to ampicillin, chloramphenicol, streptomycin/spectinomycin, sulfonamides and tetracycline, encoded by bla (OXA-1), catA1, aadA1-like, sul1 and tet(B), respectively, and carried a pUO-StVR2-like plasmid of ca.	tet	97-109	Bla	Salmonella enterica subsp. enterica serovar Typhimurium	122-125
19405119-2	2009	We screened by DNAmicroarrays the c-Jun- and transformation-related gene expression changes in S-adenosylmethionine decarboxylase (AdoMetDC)-overexpressing mouse fibroblasts that are highly invasive in vivo, and their derivatives expressing a tetracycline-inducible dominant-negative mutant of c-Jun (TAM67) or c-Jun shRNA.	tet	243-255	S-adenosylmethionine decarboxylase 1	Mus musculus	95-129
19405119-2	2009	We screened by DNAmicroarrays the c-Jun- and transformation-related gene expression changes in S-adenosylmethionine decarboxylase (AdoMetDC)-overexpressing mouse fibroblasts that are highly invasive in vivo, and their derivatives expressing a tetracycline-inducible dominant-negative mutant of c-Jun (TAM67) or c-Jun shRNA.	tet	243-255	S-adenosylmethionine decarboxylase 1	Mus musculus	131-139
19583181-4	2009	The migration velocities of parental epithelial cells and of cells engineered to express E-cadherin under tetracycline control show that E-cadherin expression reduces cell motility by both adhesion-dependent and adhesion-independent mechanisms.	tet	106-118	cadherin 1	Homo sapiens	89-99
19583181-4	2009	The migration velocities of parental epithelial cells and of cells engineered to express E-cadherin under tetracycline control show that E-cadherin expression reduces cell motility by both adhesion-dependent and adhesion-independent mechanisms.	tet	106-118	cadherin 1	Homo sapiens	137-147
19442649-2	2009	To explore the interactome of GCH-1, we established a HEK 293 cell line stably expressing tetracycline-inducible FLAG-GCH-1.	tet	90-102	GTP cyclohydrolase 1	Homo sapiens	30-35
19326874-0	2009	Inclusion of tetracycline hydrochloride within supramolecular gels and its controlled release to bovine serum albumin.	tet	13-39	albumin	Homo sapiens	104-117
19556244-6	2009	Similarly, down-regulation of mucin O-glycosylation using a stable tetracycline-inducible RNA interfering system to knockdown c1galt1 (T-synthase), a critical galactosyltransferase required for the synthesis of core 1 O-glycans, resulted in decreased cell surface O-glycosylation, reduced cell surface galectin-3, and increased epithelial permeability.	tet	67-79	LOC100508689	Homo sapiens	30-35
19556244-6	2009	Similarly, down-regulation of mucin O-glycosylation using a stable tetracycline-inducible RNA interfering system to knockdown c1galt1 (T-synthase), a critical galactosyltransferase required for the synthesis of core 1 O-glycans, resulted in decreased cell surface O-glycosylation, reduced cell surface galectin-3, and increased epithelial permeability.	tet	67-79	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	126-133
19556244-6	2009	Similarly, down-regulation of mucin O-glycosylation using a stable tetracycline-inducible RNA interfering system to knockdown c1galt1 (T-synthase), a critical galactosyltransferase required for the synthesis of core 1 O-glycans, resulted in decreased cell surface O-glycosylation, reduced cell surface galectin-3, and increased epithelial permeability.	tet	67-79	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	135-145
19509279-4	2009	Using 293 cells that ectopically express ATF4 in a tetracycline-inducible manner showed that ATF4 target genes were activated in the absence of amino acid deprivation.	tet	51-63	activating transcription factor 4	Homo sapiens	41-45
19509279-4	2009	Using 293 cells that ectopically express ATF4 in a tetracycline-inducible manner showed that ATF4 target genes were activated in the absence of amino acid deprivation.	tet	51-63	activating transcription factor 4	Homo sapiens	93-97
19602589-5	2009	To investigate the role of GPR87 in the p53 pathway, we generated multiple RKO and MCF7 cell lines in that GPR87 can be inducibly overexpressed or knocked down by a tetracycline-inducible system.	tet	165-177	tumor protein p53	Homo sapiens	40-43
19602589-5	2009	To investigate the role of GPR87 in the p53 pathway, we generated multiple RKO and MCF7 cell lines in that GPR87 can be inducibly overexpressed or knocked down by a tetracycline-inducible system.	tet	165-177	G protein-coupled receptor 87	Homo sapiens	107-112
19637235-2	2009	To explore direct HIF-1 targets, here we used differential gel electrophoresis (DIGE) to compare the HIF-1-regulated proteins between leukemic U937T-cell line with and without conditional induction of HIF-1alpha protein by tetracycline-off system.	tet	223-235	hypoxia inducible factor 1 subunit alpha	Homo sapiens	201-211
19442649-2	2009	To explore the interactome of GCH-1, we established a HEK 293 cell line stably expressing tetracycline-inducible FLAG-GCH-1.	tet	90-102	GTP cyclohydrolase 1	Homo sapiens	118-123
19581598-4	2009	Here, we report the study of human OR17-4 (hOR17-4) purified from a HEK293S tetracycline-inducible system.	tet	76-88	olfactory receptor family 1 subfamily D member 2	Homo sapiens	35-41
19362124-7	2009	Therefore, in this study we used the tetracycline transactivator system to increase p35/GFP in neuronal cells, treated with amyloid beta 1-42 (Abeta(1-42)) peptide.	tet	37-49	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	84-87
19362124-9	2009	This effect could be reversed by the addition of tetracycline in the culture medium, suggesting synergistic effects of p35 over-expression and Abeta treatment in the apoptosis of neuronal cells.	tet	49-61	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	119-122
19581598-4	2009	Here, we report the study of human OR17-4 (hOR17-4) purified from a HEK293S tetracycline-inducible system.	tet	76-88	olfactory receptor family 1 subfamily D member 2	Homo sapiens	43-50
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	tet	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	151-164
19426717-3	2009	We isolated mBest1 transcript from mouse heart and analyzed the biophysical properties and expression of this channel protein using a tetracycline inducible system.	tet	134-146	bestrophin 1	Mus musculus	12-18
19427351-2	2009	Tetracycline-induced fatty liver was partly due to the disturbance of mitochondrial fatty acids beta-oxidation regulated by PPARalpha.	tet	0-12	peroxisome proliferator activated receptor alpha	Mus musculus	124-133
19427351-13	2009	Bicyclol protected against tetracycline-induced fatty liver mainly through modulating the disturbance of PPARalpha pathway and ameliorating mitochondrial function.	tet	27-39	peroxisome proliferator activated receptor alpha	Mus musculus	105-114
19097982-4	2009	In this study, we used a lung-specific, tetracycline-inducible IL-10 overexpression-transgenic (IL-10 OE) mouse to study the effects of IL-10 overexpression on Pseudomonas aeruginosa-induced lung inflammation and corresponding survival in mice.	tet	40-52	interleukin 10	Mus musculus	63-68
19097982-4	2009	In this study, we used a lung-specific, tetracycline-inducible IL-10 overexpression-transgenic (IL-10 OE) mouse to study the effects of IL-10 overexpression on Pseudomonas aeruginosa-induced lung inflammation and corresponding survival in mice.	tet	40-52	interleukin 10	Mus musculus	96-101
19097982-4	2009	In this study, we used a lung-specific, tetracycline-inducible IL-10 overexpression-transgenic (IL-10 OE) mouse to study the effects of IL-10 overexpression on Pseudomonas aeruginosa-induced lung inflammation and corresponding survival in mice.	tet	40-52	interleukin 10	Mus musculus	96-101
19483305-6	2009	Here we establish murine embryonic stem (ES) cell lines in which expression of either the human Pax6 or Pax6-5a isoform is negatively controlled by tetracycline.	tet	148-160	paired box 6	Homo sapiens	96-100
19483305-6	2009	Here we establish murine embryonic stem (ES) cell lines in which expression of either the human Pax6 or Pax6-5a isoform is negatively controlled by tetracycline.	tet	148-160	paired box 6	Mus musculus	104-108
19419994-6	2009	Phosphorylation studies of CFTR in human embryonic kidney-293 cells using tetracycline-inducible expression of AMPK-DN demonstrated AMPK-dependent phosphorylation of CFTR in vivo.	tet	74-86	CF transmembrane conductance regulator	Homo sapiens	27-31
19419994-6	2009	Phosphorylation studies of CFTR in human embryonic kidney-293 cells using tetracycline-inducible expression of AMPK-DN demonstrated AMPK-dependent phosphorylation of CFTR in vivo.	tet	74-86	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	111-115
19419994-6	2009	Phosphorylation studies of CFTR in human embryonic kidney-293 cells using tetracycline-inducible expression of AMPK-DN demonstrated AMPK-dependent phosphorylation of CFTR in vivo.	tet	74-86	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	132-136
19419994-6	2009	Phosphorylation studies of CFTR in human embryonic kidney-293 cells using tetracycline-inducible expression of AMPK-DN demonstrated AMPK-dependent phosphorylation of CFTR in vivo.	tet	74-86	CF transmembrane conductance regulator	Homo sapiens	166-170
19293248-4	2009	After breeding with mice carrying the tetracycline receptor, compound mice express MnSOD depending on the presence of tetracycline.	tet	38-50	superoxide dismutase 2, mitochondrial	Mus musculus	83-88
19258280-4	2009	The inactivation of the mexB gene (which codes for the RND transporter MexB) in the 11 selected strains showed that the Tic(hs) phenotype was due to a mutational or functional loss of function of MexAB-OprM, the multidrug efflux system known to contribute to the natural resistance of P. aeruginosa to beta-lactams (e.g., ticarcillin and aztreonam), fluoroquinolones, tetracycline, and novobiocin.	tet	368-380	multidrug resistance protein MexB	Pseudomonas aeruginosa PAO1	24-28
19258280-4	2009	The inactivation of the mexB gene (which codes for the RND transporter MexB) in the 11 selected strains showed that the Tic(hs) phenotype was due to a mutational or functional loss of function of MexAB-OprM, the multidrug efflux system known to contribute to the natural resistance of P. aeruginosa to beta-lactams (e.g., ticarcillin and aztreonam), fluoroquinolones, tetracycline, and novobiocin.	tet	368-380	multidrug resistance protein MexB	Pseudomonas aeruginosa PAO1	71-75
19258275-2	2009	In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK).	tet	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
19342889-4	2009	In order to characterize the isolated effect of both HIFalpha isoforms on the cell cycle we generated tetracycline inducible, HIF-1alpha and -2alpha expressing NIH3T3 cells.	tet	102-114	hypoxia inducible factor 1, alpha subunit	Mus musculus	126-148
19435810-1	2009	We used a double transgenic tetracycline system to conditionally express A-CREB, a dominant negative protein that prevents the DNA binding and function of cAMP-responsive element binding protein (CREB) family members, in mouse basal epidermis using the keratin 5 promoter.	tet	28-40	cAMP responsive element binding protein 1	Mus musculus	75-79
19270112-5	2009	This was done by depleting its backbone, the cullin Cdc53p (orf19.1674), using a tetracycline downregulatable promoter system.	tet	81-93	cullin CDC53	Saccharomyces cerevisiae S288C	52-58
19141541-7	2009	Thus, a conditional construct inserted in single copy and in predetermined orientation at the HPRT locus demonstrated a Dox-dependent gene expression phenotype in adult mice suggesting that controlled insertion of tet-inducible constructs at the HPRT locus can provide an efficient alternative strategy to reproducibly generate animal models with tetracycline-induced transgene expression.	tet	347-359	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	94-98
18195714-3	2009	Blockade of IDO activation either indirectly with the anti-inflammatory tetracycline derivative minocycline, that attenuates LPS-induced expression of proinflammatory cytokines, or directly with the IDO antagonist 1-methyltryptophan (1-MT), prevents development of depressive-like behavior.	tet	72-84	indoleamine 2,3-dioxygenase 1	Mus musculus	12-15
19135102-6	2009	We thereby generated a "tetracycline-inducible conditional gene knockout" for the proliferation-associated SNF2-like gene (PASG) in a Nalm-6 cell line, in which the expression of PASG can be depleted in a tetracycline-dependent manner on a knockout background.	tet	24-36	helicase, lymphoid specific	Homo sapiens	82-121
19135102-6	2009	We thereby generated a "tetracycline-inducible conditional gene knockout" for the proliferation-associated SNF2-like gene (PASG) in a Nalm-6 cell line, in which the expression of PASG can be depleted in a tetracycline-dependent manner on a knockout background.	tet	24-36	helicase, lymphoid specific	Homo sapiens	123-127
19135102-6	2009	We thereby generated a "tetracycline-inducible conditional gene knockout" for the proliferation-associated SNF2-like gene (PASG) in a Nalm-6 cell line, in which the expression of PASG can be depleted in a tetracycline-dependent manner on a knockout background.	tet	24-36	helicase, lymphoid specific	Homo sapiens	179-183
19135102-6	2009	We thereby generated a "tetracycline-inducible conditional gene knockout" for the proliferation-associated SNF2-like gene (PASG) in a Nalm-6 cell line, in which the expression of PASG can be depleted in a tetracycline-dependent manner on a knockout background.	tet	205-217	helicase, lymphoid specific	Homo sapiens	82-121
19135102-6	2009	We thereby generated a "tetracycline-inducible conditional gene knockout" for the proliferation-associated SNF2-like gene (PASG) in a Nalm-6 cell line, in which the expression of PASG can be depleted in a tetracycline-dependent manner on a knockout background.	tet	205-217	helicase, lymphoid specific	Homo sapiens	123-127
19135102-6	2009	We thereby generated a "tetracycline-inducible conditional gene knockout" for the proliferation-associated SNF2-like gene (PASG) in a Nalm-6 cell line, in which the expression of PASG can be depleted in a tetracycline-dependent manner on a knockout background.	tet	205-217	helicase, lymphoid specific	Homo sapiens	179-183
19188335-5	2009	Using rat osteosarcoma T6-N4 cells expressing the endogenous PTH1R, in which NHERF1 expression could be induced by tetracycline, PTH1R desensitization was assessed by measuring adenylyl cyclase activity after successive PTH challenges.	tet	115-127	parathyroid hormone 1 receptor	Rattus norvegicus	61-66
19188335-5	2009	Using rat osteosarcoma T6-N4 cells expressing the endogenous PTH1R, in which NHERF1 expression could be induced by tetracycline, PTH1R desensitization was assessed by measuring adenylyl cyclase activity after successive PTH challenges.	tet	115-127	SLC9A3 regulator 1	Rattus norvegicus	77-83
19265675-3	2009	The expression of the beta(2)AR-Venus fusion protein was tightly controlled using a tetracycline-induced promoter.	tet	84-96	adrenoceptor beta 2	Homo sapiens	22-31
19141541-7	2009	Thus, a conditional construct inserted in single copy and in predetermined orientation at the HPRT locus demonstrated a Dox-dependent gene expression phenotype in adult mice suggesting that controlled insertion of tet-inducible constructs at the HPRT locus can provide an efficient alternative strategy to reproducibly generate animal models with tetracycline-induced transgene expression.	tet	347-359	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	246-250
19516083-7	2009	We have shown that rats treated by Tetracycline reduce the MMP-2 expression and HSP-70.	tet	35-47	matrix metallopeptidase 2	Rattus norvegicus	59-64
19516083-7	2009	We have shown that rats treated by Tetracycline reduce the MMP-2 expression and HSP-70.	tet	35-47	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	80-86
19565779-5	2009	The action duration of tetracycline on the activities of soil urease, catalase, sucrase and proteinase were 7 weeks, 6-8 weeks, 7 weeks, and 6-7 weeks, respectively.	tet	23-35	catalase-3-like	Brassica napus	70-78
19350677-2	2009	We have developed a tetracycline-inducible short hairpin RNA interference (shRNAi) for human embryonic stem cells (hESCs) and demonstrated doxycycline dose-dependent knockdown of the transcription factor OCT4 and the cell surface antigen beta2-microglobulin.	tet	20-32	POU class 5 homeobox 1	Homo sapiens	204-208
19153075-4	2009	Expression of the mutant beta2 subunit is driven by a neuronal-specific tetracycline-controlled promoter, which allows planned silencing of transgene expression in a reversible fashion and tracking the involvement of mutant receptor in crucial phases of epileptogenesis.	tet	72-84	hemoglobin, beta adult minor chain	Mus musculus	25-30
19165829-2	2009	To investigate the pathophysiological roles of EC-SOD, we generated tetracycline-inducible Sod3 transgenic mice and directed the tissue-specific expression of transgenes by crossing Sod3 transgenic mice with tissue-specific transactivator transgenics.	tet	68-80	superoxide dismutase 3, extracellular	Mus musculus	91-95
19291219-7	2009	By tetracycline-dependent abrogation of A30P alpha-synuclein expression, OB neurogenesis and programmed cell death was restored to control levels.	tet	3-15	synuclein, alpha	Mus musculus	45-60
18830273-4	2009	The keratin 5 promoter was used with a tetracycline-inducible system to target IL-13 to the skin.	tet	39-51	interleukin 13	Mus musculus	79-84
19489364-8	2009	Our CA-MRSA isolates were 98.6% sensitive to trimethoprim-sulfamethoxasole, 94.4% sensitive to tetracycline, 90.8% sensitive to clindamycin, and 59.9% sensitive to levofloxacin.	tet	95-107	solute carrier family 9 member A6	Homo sapiens	7-11
19056765-3	2009	Under basal conditions, DRA activity was low in normal and infected Caco2BBE cells in the presence of tetracycline, whereas NHE activities could be easily detected.	tet	102-114	solute carrier family 26 member 3	Homo sapiens	24-27
19105207-3	2009	When c-myc/OVA transgenic mice were crossed with liver-specific inducer mice, multifocal hepatocellular carcinomas co-expressing OVA developed in a tetracycline-dependent manner with a short latency and 100% penetrance.	tet	148-160	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	11-14
19027885-1	2009	A tetracycline inducible transfectant cell line (3D5) capable of producing soluble and sarkosyl-insoluble assemblies of wild-type human alpha-synuclein (alpha-Syn) upon differentiation with retinoic acid was used to study the impact of alpha-Syn accumulation on protein phosphorylation and glycosylation.	tet	2-14	synuclein alpha	Homo sapiens	136-151
19027885-1	2009	A tetracycline inducible transfectant cell line (3D5) capable of producing soluble and sarkosyl-insoluble assemblies of wild-type human alpha-synuclein (alpha-Syn) upon differentiation with retinoic acid was used to study the impact of alpha-Syn accumulation on protein phosphorylation and glycosylation.	tet	2-14	synuclein alpha	Homo sapiens	153-162
19027885-1	2009	A tetracycline inducible transfectant cell line (3D5) capable of producing soluble and sarkosyl-insoluble assemblies of wild-type human alpha-synuclein (alpha-Syn) upon differentiation with retinoic acid was used to study the impact of alpha-Syn accumulation on protein phosphorylation and glycosylation.	tet	2-14	synuclein alpha	Homo sapiens	236-245
18996208-2	2009	We introduced the tetracycline-dependent NeuroD2 expression system to embryonic stem (ES) cells and studied the role of NeuroD2 in the neuronal differentiation.	tet	18-30	neurogenic differentiation 2	Mus musculus	41-48
19105207-3	2009	When c-myc/OVA transgenic mice were crossed with liver-specific inducer mice, multifocal hepatocellular carcinomas co-expressing OVA developed in a tetracycline-dependent manner with a short latency and 100% penetrance.	tet	148-160	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	129-132
19086074-3	2009	To identify a possible pharmacological therapy for laminin-alpha2 deficiency, we designed this study to determine whether treatment with minocycline or doxycycline, which are tetracycline derivatives reported to have antiapoptotic effects in mammals, would significantly increase lifespan and improve neuromuscular function in laminin-alpha2-deficient mice.	tet	175-187	laminin, alpha 2	Mus musculus	51-65
18801387-0	2009	Generalized tetracycline induced Cre recombinase expression through the ROSA26 locus of recombinant mice.	tet	12-24	gene trap ROSA 26, Philippe Soriano	Mus musculus	72-78
18801387-2	2009	Here we describe the generation of a recombinant mouse that combines a tetracycline dependent switch with generalized Cre recombinase expression by targeting the ubiquitously expressed ROSA26 locus.	tet	71-83	gene trap ROSA 26, Philippe Soriano	Mus musculus	185-191
18801387-5	2009	The tetracycline inducible promoter, cloned in opposite orientation to the ROSA26 locus and separated from the rtTA element by a 5 kb human p53 intron, drives Cre recombinase expression.	tet	4-16	gene trap ROSA 26, Philippe Soriano	Mus musculus	75-81
18801387-5	2009	The tetracycline inducible promoter, cloned in opposite orientation to the ROSA26 locus and separated from the rtTA element by a 5 kb human p53 intron, drives Cre recombinase expression.	tet	4-16	tumor protein p53	Homo sapiens	140-143
18984587-9	2009	In the tetracycline-regulated expression system of KCC4 in the HEK293 cells stably expressing gastric H+,K+-ATPase, KCC4 was coimmunoprecipitated with H+,K+-ATPase.	tet	7-19	solute carrier family 12 member 7	Homo sapiens	51-55
18984587-9	2009	In the tetracycline-regulated expression system of KCC4 in the HEK293 cells stably expressing gastric H+,K+-ATPase, KCC4 was coimmunoprecipitated with H+,K+-ATPase.	tet	7-19	solute carrier family 12 member 7	Homo sapiens	116-120
19023031-6	2009	By utilizing tetracycline-dependent gene expression and microarray analysis, we identified a novel group of genes that are regulated downstream of Notch1 within intestinal epithelial cells, including PLA2G2A, an antimicrobial peptide secreted by Paneth cells.	tet	13-25	notch receptor 1	Homo sapiens	147-153
19023031-6	2009	By utilizing tetracycline-dependent gene expression and microarray analysis, we identified a novel group of genes that are regulated downstream of Notch1 within intestinal epithelial cells, including PLA2G2A, an antimicrobial peptide secreted by Paneth cells.	tet	13-25	phospholipase A2 group IIA	Homo sapiens	200-207
19384577-8	2009	Minocycline prevented hPrP90-231-induced toxicity interfering with this mechanism: the pretreatment with this tetracycline restored ERK1/2 activity and reverted p38 and caspase 3 activities.	tet	110-122	mitogen-activated protein kinase 14	Homo sapiens	161-164
19384577-8	2009	Minocycline prevented hPrP90-231-induced toxicity interfering with this mechanism: the pretreatment with this tetracycline restored ERK1/2 activity and reverted p38 and caspase 3 activities.	tet	110-122	caspase 3	Homo sapiens	169-178
18753740-3	2009	Glomerular cells, isolated from transgenic mice bear- ing two transgenes, NPHS2-reverse tetracycline-controlled transactivator, rtTA (A transgene) and H2-Kb-thermosensitive SV40 T, ts58A (I transgene), were cloned.	tet	88-100	nephrosis 2, podocin	Mus musculus	74-79
19118031-3	2009	EXPERIMENTAL DESIGN: Castration-resistant C4-2 human prostate cancer cells stably expressing a tetracycline-inducible AR-targeted short hairpin RNA (shRNA) were generated to directly test the effects of AR knockdown in C4-2 human prostate cancer cells and tumors.	tet	95-107	androgen receptor	Homo sapiens	118-120
18663604-3	2009	To regulate the Cnx expression level, a tetracycline-inducible system was used.	tet	40-52	calnexin	Rattus norvegicus	16-19
19037705-2	2009	We have generated embryonic stem (ES) cell lines that repress Pax2 expression in a tetracycline-dependent manner.	tet	83-95	paired box 2	Mus musculus	62-66
18996370-4	2009	Microarray analysis using a tetracycline-inducible LMX1B expression system in HeLa cells revealed that a subset of NF-kappaB target genes, including IL-6 and IL-8, are upregulated in LMX1B-expressing cells.	tet	28-40	LIM homeobox transcription factor 1 beta	Homo sapiens	51-56
18996370-4	2009	Microarray analysis using a tetracycline-inducible LMX1B expression system in HeLa cells revealed that a subset of NF-kappaB target genes, including IL-6 and IL-8, are upregulated in LMX1B-expressing cells.	tet	28-40	nuclear factor kappa B subunit 1	Homo sapiens	115-124
18996370-4	2009	Microarray analysis using a tetracycline-inducible LMX1B expression system in HeLa cells revealed that a subset of NF-kappaB target genes, including IL-6 and IL-8, are upregulated in LMX1B-expressing cells.	tet	28-40	interleukin 6	Homo sapiens	149-153
18996370-4	2009	Microarray analysis using a tetracycline-inducible LMX1B expression system in HeLa cells revealed that a subset of NF-kappaB target genes, including IL-6 and IL-8, are upregulated in LMX1B-expressing cells.	tet	28-40	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
18996370-4	2009	Microarray analysis using a tetracycline-inducible LMX1B expression system in HeLa cells revealed that a subset of NF-kappaB target genes, including IL-6 and IL-8, are upregulated in LMX1B-expressing cells.	tet	28-40	LIM homeobox transcription factor 1 beta	Homo sapiens	183-188
19100521-3	2009	In this study, we have used a tetracycline-regulated system to express wild-type and the mutated F2 Tel/PDGFRbeta to identify the key signaling pathways, which drive Tel/PDGFRbeta-induced differentiation of embryonic stem (ES) cells.	tet	30-42	ETS variant transcription factor 6	Homo sapiens	100-103
19100521-3	2009	In this study, we have used a tetracycline-regulated system to express wild-type and the mutated F2 Tel/PDGFRbeta to identify the key signaling pathways, which drive Tel/PDGFRbeta-induced differentiation of embryonic stem (ES) cells.	tet	30-42	platelet derived growth factor receptor beta	Homo sapiens	104-113
19100521-3	2009	In this study, we have used a tetracycline-regulated system to express wild-type and the mutated F2 Tel/PDGFRbeta to identify the key signaling pathways, which drive Tel/PDGFRbeta-induced differentiation of embryonic stem (ES) cells.	tet	30-42	ETS variant transcription factor 6	Homo sapiens	166-169
19100521-3	2009	In this study, we have used a tetracycline-regulated system to express wild-type and the mutated F2 Tel/PDGFRbeta to identify the key signaling pathways, which drive Tel/PDGFRbeta-induced differentiation of embryonic stem (ES) cells.	tet	30-42	platelet derived growth factor receptor beta	Homo sapiens	170-179
19096299-4	2009	Nevertheless, several lines of evidence indicate that the T790M mutation confers growth advantage to cancer cells, and it was shown that mice expressing tetracycline-inducible EGFR transgenes harboring the T790M mutation develop lung tumors.	tet	153-165	epidermal growth factor receptor	Mus musculus	176-180
19205460-14	2009	Except for one isolate, all tetracycline-resistant isolates were negative for the virulence genes eaeA and e-hlyA or stx1.	tet	28-40	hemolysin transport protein	Escherichia coli	109-113
19032078-3	2008	Recently, however, the crystal structure of a complex between Tc and trypsin-modified elongation factor Tu (tm-EF-Tu) was determined, raising the question of whether Tc binding to EF-Tu has a role in its inhibition of protein synthesis.	tet	62-64	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	86-106
19348886-4	2009	In this chapter, we describe an approach to regulate the expression levels of an AcGFP(1)-tagged subunit (NDUFS3) in mammalian cells by means of a tetracycline-inducible promoter.	tet	147-159	NADH:ubiquinone oxidoreductase core subunit S3	Homo sapiens	106-112
19158953-4	2009	Next, we established a Hela cell line, where scapinin expression was induced by tetracycline.	tet	80-92	phosphatase and actin regulator 3	Homo sapiens	45-53
19340286-3	2009	To this purpose, we employed a tetracycline-inducible shRNA expression system targeting the insulin receptor (IR).	tet	31-43	insulin receptor	Rattus norvegicus	92-108
19340286-3	2009	To this purpose, we employed a tetracycline-inducible shRNA expression system targeting the insulin receptor (IR).	tet	31-43	insulin receptor	Rattus norvegicus	110-112
19032078-3	2008	Recently, however, the crystal structure of a complex between Tc and trypsin-modified elongation factor Tu (tm-EF-Tu) was determined, raising the question of whether Tc binding to EF-Tu has a role in its inhibition of protein synthesis.	tet	62-64	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	111-116
19032078-3	2008	Recently, however, the crystal structure of a complex between Tc and trypsin-modified elongation factor Tu (tm-EF-Tu) was determined, raising the question of whether Tc binding to EF-Tu has a role in its inhibition of protein synthesis.	tet	166-168	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	86-106
19032078-3	2008	Recently, however, the crystal structure of a complex between Tc and trypsin-modified elongation factor Tu (tm-EF-Tu) was determined, raising the question of whether Tc binding to EF-Tu has a role in its inhibition of protein synthesis.	tet	166-168	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	180-185
18852022-1	2008	The tetracycline antibiotic minocycline beneficially affects neuronal functioning and also inhibits the enzyme 5-lipoxygenase (5-LOX).	tet	4-16	arachidonate 5-lipoxygenase	Mus musculus	111-125
18794809-4	2008	In our current report, we used DLD-1 colorectal cancer cells stably transfected with the POX gene under the control of a tetracycline-inducible promoter and found that three pathways which cross talk with each other were downregulated by POX: the cyclooxygenase-2 (COX-2) pathway, the epidermal growth factor receptor (EGFR) pathway and the Wnt/beta-catenin pathway.	tet	121-133	proline dehydrogenase 1	Homo sapiens	89-92
18930044-1	2008	In order to clarify the role of HMW FGF-2 in glioma development and angiogenesis, we over-expressed different human FGF-2 isoforms in C6 rat glioma cell line using a tetracycline-regulated expression system.	tet	166-178	fibroblast growth factor 2	Homo sapiens	36-41
18930044-1	2008	In order to clarify the role of HMW FGF-2 in glioma development and angiogenesis, we over-expressed different human FGF-2 isoforms in C6 rat glioma cell line using a tetracycline-regulated expression system.	tet	166-178	fibroblast growth factor 2	Homo sapiens	116-121
18776920-3	2008	In this study, we developed novel transgenic mice that conditionally express mGluR1 in melanocytes, using a tetracycline regulatory system.	tet	108-120	glutamate receptor, metabotropic 1	Mus musculus	77-83
18794809-4	2008	In our current report, we used DLD-1 colorectal cancer cells stably transfected with the POX gene under the control of a tetracycline-inducible promoter and found that three pathways which cross talk with each other were downregulated by POX: the cyclooxygenase-2 (COX-2) pathway, the epidermal growth factor receptor (EGFR) pathway and the Wnt/beta-catenin pathway.	tet	121-133	proline dehydrogenase 1	Homo sapiens	238-241
18955141-4	2008	Using the human T47D breast cancer cell line with tetracycline-dependent ERbeta expression (T47D-ERbeta), the effect of a varying intracellular ERalpha/ERbeta ratio on E2- or pythoestrogen-induced cell proliferation was characterised.	tet	50-62	estrogen receptor 2	Homo sapiens	73-79
18957893-2	2008	To model Lewy body-associated neurodegeneration, we generated transfectant 3D5 of human neuronal-type in which expression of human wild-type alpha-syn is regulated by the tetracycline off (TetOff)-inducible mechanism.	tet	171-183	synuclein alpha	Homo sapiens	141-150
18955051-3	2008	Previously, we established a tetracycline-regulated human cell line that can be induced to express PPARalpha and identified candidate target genes, one of which was PDZK1.	tet	29-41	peroxisome proliferator activated receptor alpha	Homo sapiens	99-108
18955051-3	2008	Previously, we established a tetracycline-regulated human cell line that can be induced to express PPARalpha and identified candidate target genes, one of which was PDZK1.	tet	29-41	PDZ domain containing 1	Homo sapiens	165-170
18799637-4	2008	To test this hypothesis, we generated a cardiac-specific tetracycline-inducible double transgenic mouse, which allows for doxycycline (DOX)-based inducible SERCA2a expression in which DOX exposure turns on SERCA2a expression.	tet	57-69	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	156-163
18799637-4	2008	To test this hypothesis, we generated a cardiac-specific tetracycline-inducible double transgenic mouse, which allows for doxycycline (DOX)-based inducible SERCA2a expression in which DOX exposure turns on SERCA2a expression.	tet	57-69	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	206-213
18796538-7	2008	Tetracycline-regulated expression of Snail induced the differentiation of MESECs into mural cells, whereas knockdown of Snail expression abrogated TGFbeta2-induced mural differentiation of MESECs.	tet	0-12	snail family zinc finger 1	Mus musculus	37-42
18796538-7	2008	Tetracycline-regulated expression of Snail induced the differentiation of MESECs into mural cells, whereas knockdown of Snail expression abrogated TGFbeta2-induced mural differentiation of MESECs.	tet	0-12	transforming growth factor, beta 2	Mus musculus	147-155
18723766-6	2008	To develop a strategy to allow temporally controlled overexpression of cardiac PI3Kalpha, we engineered a tetracycline (tet) transactivator tet-off controlled transgenic mouse line with a conditional overexpression of a cardiac-specific fusion protein of the SH2 domain of p85 and p110alpha.	tet	106-118	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	79-88
18723766-6	2008	To develop a strategy to allow temporally controlled overexpression of cardiac PI3Kalpha, we engineered a tetracycline (tet) transactivator tet-off controlled transgenic mouse line with a conditional overexpression of a cardiac-specific fusion protein of the SH2 domain of p85 and p110alpha.	tet	106-109	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	79-88
18723766-6	2008	To develop a strategy to allow temporally controlled overexpression of cardiac PI3Kalpha, we engineered a tetracycline (tet) transactivator tet-off controlled transgenic mouse line with a conditional overexpression of a cardiac-specific fusion protein of the SH2 domain of p85 and p110alpha.	tet	120-123	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	79-88
18341570-0	2008	Tetracycline suppresses ATP gamma S-induced CXCL8 and CXCL1 production by the human dermal microvascular endothelial cell-1 (HMEC-1) cell line and primary human dermal microvascular endothelial cells.	tet	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	44-49
18644836-5	2008	The effects of these selective estrogen receptor modulators (SERMs) and of the model compound E2 on the proliferation of T47D human breast cancer cells with tetracycline-dependent expression of ERbeta (T47D-ERbeta) were characterized.	tet	157-169	estrogen receptor 2	Homo sapiens	194-200
18644836-5	2008	The effects of these selective estrogen receptor modulators (SERMs) and of the model compound E2 on the proliferation of T47D human breast cancer cells with tetracycline-dependent expression of ERbeta (T47D-ERbeta) were characterized.	tet	157-169	estrogen receptor 2	Homo sapiens	207-213
18829573-6	2008	This is the first study to use a tetracycline-responsive vector expression system to study PTPRG stable transfectants.	tet	33-45	protein tyrosine phosphatase, receptor type, G	Mus musculus	91-96
18728194-2	2008	Conditional expression of Separase in tetracycline-inducible diploid FSK3 mouse mammary epithelial cells with both p53 WT and mutant (Ser-233-234) alleles of unknown physiological significance develops aneuploidy within 5 days of Separase induction in vitro.	tet	38-50	extra spindle pole bodies 1, separase	Mus musculus	26-34
18728194-2	2008	Conditional expression of Separase in tetracycline-inducible diploid FSK3 mouse mammary epithelial cells with both p53 WT and mutant (Ser-233-234) alleles of unknown physiological significance develops aneuploidy within 5 days of Separase induction in vitro.	tet	38-50	transformation related protein 53, pseudogene	Mus musculus	115-118
18341570-0	2008	Tetracycline suppresses ATP gamma S-induced CXCL8 and CXCL1 production by the human dermal microvascular endothelial cell-1 (HMEC-1) cell line and primary human dermal microvascular endothelial cells.	tet	0-12	C-X-C motif chemokine ligand 1	Homo sapiens	54-59
18624926-5	2008	We developed a novel GnRH-secreting cell line transgenic mouse model suitable for targeted transformation in post-pubertal mice using a tetracycline-regulated TAg transgene.	tet	136-148	gonadotropin releasing hormone 1	Mus musculus	21-25
18624926-7	2008	GRT cells grown in medium containing tetracycline-free serum express increasing mRNA levels of GnRH associated with declining levels of TAg expression.	tet	37-49	gonadotropin releasing hormone 1	Mus musculus	95-99
18624926-8	2008	The novelty and ultimately the usefulness of this cell line is that TAg expression, which could affect the GnRH neuronal phenotype, can be regulated by tetracycline.	tet	152-164	gonadotropin releasing hormone 1	Mus musculus	107-111
18698031-3	2008	EXPERIMENTAL DESIGN: Chk1 was abrogated by transient transfection of specific siRNA against it, and stable tetracycline-inducible Chk1 siRNA clones were obtained transfecting cells with a plasmid expressing two siRNA against Chk1.	tet	107-119	checkpoint kinase 1	Mus musculus	130-134
18543329-0	2008	Tetracycline to prevent epidermal growth factor receptor inhibitor-induced skin rashes: results of a placebo-controlled trial from the North Central Cancer Treatment Group (N03CB).	tet	0-12	epidermal growth factor receptor	Homo sapiens	24-56
18698031-3	2008	EXPERIMENTAL DESIGN: Chk1 was abrogated by transient transfection of specific siRNA against it, and stable tetracycline-inducible Chk1 siRNA clones were obtained transfecting cells with a plasmid expressing two siRNA against Chk1.	tet	107-119	checkpoint kinase 1	Mus musculus	130-134
18698031-8	2008	These clones were transplanted in nude mice and a clear Chk1 down-regulation was shown in tumor samples of mice given tetracycline in the drinking water by immunohistochemical detection of Chk1 protein.	tet	118-130	checkpoint kinase 1	Mus musculus	56-60
18698031-8	2008	These clones were transplanted in nude mice and a clear Chk1 down-regulation was shown in tumor samples of mice given tetracycline in the drinking water by immunohistochemical detection of Chk1 protein.	tet	118-130	checkpoint kinase 1	Mus musculus	189-193
18565564-3	2008	We utilized a bitransgenic mouse lung tumor model that expressed the human Ki-ras(G12C) allele in a tetracycline-inducible, lung-specific manner.	tet	100-112	KRAS proto-oncogene, GTPase	Homo sapiens	75-81
18682799-2	2008	Here we demonstrate the production and expression of a synthetically engineered human olfactory receptor hOR17-4 gene in a stable tetracycline-inducible mammalian cell line (HEK293S).	tet	130-142	olfactory receptor family 1 subfamily D member 2	Homo sapiens	105-112
18667694-4	2008	We turned on constitutively active Notch4 (int3) expression in endothelial cells from birth by using the tetracycline-regulatable system.	tet	105-117	notch 4	Mus musculus	35-41
18667694-4	2008	We turned on constitutively active Notch4 (int3) expression in endothelial cells from birth by using the tetracycline-regulatable system.	tet	105-117	notch 4	Mus musculus	43-47
18682799-4	2008	Induction of adherent cultures with tetracycline together with sodium butyrate led to hOR17-4 expression levels of approximately 30 microg per 150 mm tissue culture plate.	tet	36-48	olfactory receptor family 1 subfamily D member 2	Homo sapiens	86-93
18485084-3	2008	OBJECTIVES: We evaluated whether embryonic stem (ES) cells with a tetracycline-inducible system could secrete human FVIII.	tet	66-78	coagulation factor VIII	Homo sapiens	116-121
18666263-5	2008	In the present study, we established a tetracycline (Tet)-regulated expression system for HNF3beta in UE7T-13 BM-MSCs.	tet	39-51	forkhead box A2	Homo sapiens	90-98
18666263-5	2008	In the present study, we established a tetracycline (Tet)-regulated expression system for HNF3beta in UE7T-13 BM-MSCs.	tet	53-56	forkhead box A2	Homo sapiens	90-98
18666263-9	2008	Furthermore, the combination of Tet with basic fibroblast growth factor (bFGF) efficiently induced the genes such as albumin and TAT, which are associated with maturity of hepatocytes; however, it suppressed genes such as AFP and EpCAM, which are associated with immaturity of hepatocytes, suggesting that Tet-induced HNF3beta expression sensitizes BM-MSCs to bFGF signals.	tet	32-35	alpha fetoprotein	Homo sapiens	222-225
18666263-9	2008	Furthermore, the combination of Tet with basic fibroblast growth factor (bFGF) efficiently induced the genes such as albumin and TAT, which are associated with maturity of hepatocytes; however, it suppressed genes such as AFP and EpCAM, which are associated with immaturity of hepatocytes, suggesting that Tet-induced HNF3beta expression sensitizes BM-MSCs to bFGF signals.	tet	32-35	epithelial cell adhesion molecule	Homo sapiens	230-235
18666263-9	2008	Furthermore, the combination of Tet with basic fibroblast growth factor (bFGF) efficiently induced the genes such as albumin and TAT, which are associated with maturity of hepatocytes; however, it suppressed genes such as AFP and EpCAM, which are associated with immaturity of hepatocytes, suggesting that Tet-induced HNF3beta expression sensitizes BM-MSCs to bFGF signals.	tet	32-35	forkhead box A2	Homo sapiens	318-326
18505790-6	2008	CYP3A4 activity was significantly increased by rifampin (9.7-fold), nafcillin and dicloxacillin (5.9-fold), and weakly induced (2-fold) by tetracycline, sufisoxazole, troleandomycin, and clindamycin.	tet	139-151	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
18505790-9	2008	In summary, nafcillin, dicloxacillin, cephradine, tetracycline, sulfixoxazole, erythromycin, clindamycin, and griseofulvin exhibit a clear propensity to induce CYP3A4 and warrant further clinical investigation.	tet	50-62	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	160-166
18673015-5	2008	Furthermore, therapeutic approaches that target MMP-2, -8, and -9 inhibition, such as MMP inhibitors, chemically modified tetracyclines, and subantimicrobial formulations of tetracycline analogues, are discussed.	tet	122-134	matrix metallopeptidase 2	Homo sapiens	48-65
18474227-5	2008	When expression of transfected beta(2)AR in RAWar cells was downregulated by a tetracycline repressor-regulated mammalian expression system, NOS II mRNA expression was significantly increased; this suggested that the changes in the beta(2)AR expression level in macrophages associated with exercise training play a role in the regulation of NO production following LPS stimulation.	tet	79-91	adrenoceptor beta 2	Homo sapiens	31-40
18665077-4	2008	METHODS: Parental cells, cells overexpressing FGFR1-III isoforms, and cells harboring a tetracycline-inducible cyclin D1 antisense expression vector system were used as model systems.	tet	88-100	cyclin D1	Homo sapiens	111-120
18474227-5	2008	When expression of transfected beta(2)AR in RAWar cells was downregulated by a tetracycline repressor-regulated mammalian expression system, NOS II mRNA expression was significantly increased; this suggested that the changes in the beta(2)AR expression level in macrophages associated with exercise training play a role in the regulation of NO production following LPS stimulation.	tet	79-91	adrenoceptor beta 2	Homo sapiens	232-241
18421000-1	2008	OBJECTIVE: A transgenic mouse model was generated that allows conditional expression of human PLTP, based on the tetracycline-responsive gene system, to study the effects of an acute increase in plasma PLTP activity as may occur in inflammation.	tet	113-125	phospholipid transfer protein	Homo sapiens	94-98
18492670-5	2008	To investigate the functional alterations caused by the mutated DLX3(TDO) isoform ex vivo, we used tetracycline-inducible osteoblastic and keratinocyte cell lines and calvarial derived osteoblasts in which the expression of DLX3(WT) and/or DLX3(TDO) could be regulated and monitored.	tet	99-111	distal-less homeobox 3	Homo sapiens	64-68
18445125-6	2008	The second line, the GnRH-CRETeR mouse, uses the same murine GnRH promoter to target CRE expression to GnRH neurones, but is modified to be constitutively repressed by a tetracycline repressor (TetR) expressed from a downstream tetracycline repressor gene engineered within the transgene.	tet	170-182	gonadotropin releasing hormone 1	Mus musculus	21-25
18562476-5	2008	Animals treated with ghrelin showed a significant increase in new bone formation as demonstrated by an increment in bone mineral density and fluorescence labelling of tetracycline relative to the control group.	tet	167-179	ghrelin and obestatin prepropeptide	Rattus norvegicus	21-28
18445125-6	2008	The second line, the GnRH-CRETeR mouse, uses the same murine GnRH promoter to target CRE expression to GnRH neurones, but is modified to be constitutively repressed by a tetracycline repressor (TetR) expressed from a downstream tetracycline repressor gene engineered within the transgene.	tet	228-240	gonadotropin releasing hormone 1	Mus musculus	21-25
18221910-0	2008	Spectrofluorimetric determination of superoxide dismutase using a Europium-tetracycline probe.	tet	75-87	superoxide dismutase 1	Homo sapiens	37-57
18221910-1	2008	Superoxide dismutase (SOD) can enhance the characteristic fluorescence of europium in europium (Eu(3+))-tetracycline (TC) system.	tet	104-116	superoxide dismutase 1	Homo sapiens	0-20
18221910-1	2008	Superoxide dismutase (SOD) can enhance the characteristic fluorescence of europium in europium (Eu(3+))-tetracycline (TC) system.	tet	104-116	superoxide dismutase 1	Homo sapiens	22-25
18221910-1	2008	Superoxide dismutase (SOD) can enhance the characteristic fluorescence of europium in europium (Eu(3+))-tetracycline (TC) system.	tet	118-120	superoxide dismutase 1	Homo sapiens	0-20
18221910-1	2008	Superoxide dismutase (SOD) can enhance the characteristic fluorescence of europium in europium (Eu(3+))-tetracycline (TC) system.	tet	118-120	superoxide dismutase 1	Homo sapiens	22-25
18645223-3	2008	We have performed immunodetection of CIDEa in whole cells and subcellular fractions of HeLa cells adapted for a tetracycline-inducible CIDEa expression.	tet	112-124	cell death inducing DFFA like effector a	Homo sapiens	37-42
18519039-2	2008	We generated Saos-2 osteosarcoma cells expressing tetracycline-inducible Flag-tagged human Wig-1.	tet	50-62	zinc finger matrin-type 3	Homo sapiens	91-96
18540079-1	2008	We constructed a novel cancer-specific regulatable adenoviral expression system comprising two vectors: one expressing rtTA, a reverse tetracycline transactivator regulated by the human telomerase reverse transcriptase (hTERT) gene promoter, the other expressing the target gene regulated by the tetracycline response element (TRE).	tet	135-147	telomerase reverse transcriptase	Homo sapiens	220-225
18406588-8	2008	Treatment of rats with tetracycline significantly decreased the activities of superoxide dismutase, catalase (CAT), glucose-6-phosphate dehydrogenase, glutathione-S-transferase (GST) and the levels of GSH and serum testosterone, while the activity of gamma-glutamyltranspeptidase and the formation of malondialdehyde (MDA) increased.	tet	23-35	catalase	Rattus norvegicus	100-108
18406588-8	2008	Treatment of rats with tetracycline significantly decreased the activities of superoxide dismutase, catalase (CAT), glucose-6-phosphate dehydrogenase, glutathione-S-transferase (GST) and the levels of GSH and serum testosterone, while the activity of gamma-glutamyltranspeptidase and the formation of malondialdehyde (MDA) increased.	tet	23-35	catalase	Rattus norvegicus	110-113
18406588-8	2008	Treatment of rats with tetracycline significantly decreased the activities of superoxide dismutase, catalase (CAT), glucose-6-phosphate dehydrogenase, glutathione-S-transferase (GST) and the levels of GSH and serum testosterone, while the activity of gamma-glutamyltranspeptidase and the formation of malondialdehyde (MDA) increased.	tet	23-35	glucose-6-phosphate dehydrogenase	Rattus norvegicus	116-149
18406588-8	2008	Treatment of rats with tetracycline significantly decreased the activities of superoxide dismutase, catalase (CAT), glucose-6-phosphate dehydrogenase, glutathione-S-transferase (GST) and the levels of GSH and serum testosterone, while the activity of gamma-glutamyltranspeptidase and the formation of malondialdehyde (MDA) increased.	tet	23-35	hematopoietic prostaglandin D synthase	Rattus norvegicus	151-176
18406588-8	2008	Treatment of rats with tetracycline significantly decreased the activities of superoxide dismutase, catalase (CAT), glucose-6-phosphate dehydrogenase, glutathione-S-transferase (GST) and the levels of GSH and serum testosterone, while the activity of gamma-glutamyltranspeptidase and the formation of malondialdehyde (MDA) increased.	tet	23-35	hematopoietic prostaglandin D synthase	Rattus norvegicus	178-181
18187273-10	2008	Transfection of an antimicrobial-susceptible strain of S. Typhimurium with a phage propagated in a S. Heidelberg resistant to multiple beta-lactam antibiotics and tetracycline resulted in independent acquisition of bla(CMY-2), tet(A), and tet(B).	tet	163-175	Bla	Salmonella enterica subsp. enterica serovar Typhimurium	215-218
18474242-1	2008	A tetracycline-dependent inducible system was used to achieve controlled expression of the glutamate transporter 1 (GLT-1) in C6 glioma cells.	tet	2-14	solute carrier family 1 member 2	Homo sapiens	91-114
18474242-1	2008	A tetracycline-dependent inducible system was used to achieve controlled expression of the glutamate transporter 1 (GLT-1) in C6 glioma cells.	tet	2-14	solute carrier family 1 member 2	Homo sapiens	116-121
18645223-3	2008	We have performed immunodetection of CIDEa in whole cells and subcellular fractions of HeLa cells adapted for a tetracycline-inducible CIDEa expression.	tet	112-124	cell death inducing DFFA like effector a	Homo sapiens	135-140
18454161-0	2008	Trastuzumab therapy vs tetracycline controlled ERBB2 downregulation: influence on tumour development in an ERBB2-dependent mouse tumour model.	tet	23-35	erb-b2 receptor tyrosine kinase 2	Mus musculus	47-52
18474562-3	2008	To extend these studies, tetracycline-inducible stable cell lines expressing SFV nsP1 or its palmitoylation-negative mutant (nsP16D) were constructed.	tet	25-37	SH2 domain containing 3A	Homo sapiens	81-85
18281606-10	2008	Using the tetracycline (Tet)-on inducible approach, overexpression of thioredoxin (TRX) attenuated CSE-mediated cell death and JNK activation in subconfluent cultures.	tet	10-22	thioredoxin	Homo sapiens	70-81
18454859-4	2008	METHODS: We examined the modulation of apoptotic pathways by tetracycline-regulated HER-2 expression for 48 hrs in the MCF7 breast cancer cell line.	tet	61-73	erb-b2 receptor tyrosine kinase 2	Homo sapiens	84-89
18454859-6	2008	RESULTS: Tetracycline regulated short term over expression of HER-2 in the MCF7 cell line increased the antiapoptotic proteins Bcl-2 and survivin levels.	tet	9-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	62-67
18454859-6	2008	RESULTS: Tetracycline regulated short term over expression of HER-2 in the MCF7 cell line increased the antiapoptotic proteins Bcl-2 and survivin levels.	tet	9-21	BCL2 apoptosis regulator	Homo sapiens	127-132
18281606-10	2008	Using the tetracycline (Tet)-on inducible approach, overexpression of thioredoxin (TRX) attenuated CSE-mediated cell death and JNK activation in subconfluent cultures.	tet	10-22	thioredoxin	Homo sapiens	83-86
18281606-10	2008	Using the tetracycline (Tet)-on inducible approach, overexpression of thioredoxin (TRX) attenuated CSE-mediated cell death and JNK activation in subconfluent cultures.	tet	24-27	thioredoxin	Homo sapiens	70-81
18281606-10	2008	Using the tetracycline (Tet)-on inducible approach, overexpression of thioredoxin (TRX) attenuated CSE-mediated cell death and JNK activation in subconfluent cultures.	tet	24-27	thioredoxin	Homo sapiens	83-86
18381212-9	2008	Using a rtTA transactivator/tetracycline promoter approach allowing inducible and reversible attenuation of the FGFR2b signaling throughout the adult mouse, we are now reporting that FGFR2b signaling is also critical during postnatal mammary gland development.	tet	28-40	fibroblast growth factor receptor 2	Mus musculus	112-117
17934518-5	2008	To investigate the inhibitory effects of Bcr on Bcr-Abl, we expressed BCR/GFP in TonB210 cells, which contain a tetracycline-inducible BCR-ABL.	tet	112-124	BCR activator of RhoGEF and GTPase	Mus musculus	135-138
18208509-3	2008	Munc 18-1 depletion caused a loss in the secretory capacity of both transiently transfected INS 1E cells and a stable clone with tetracycline-regulated Munc 18-1 RNA interference.	tet	129-141	syntaxin binding protein 1	Rattus norvegicus	0-9
18208509-3	2008	Munc 18-1 depletion caused a loss in the secretory capacity of both transiently transfected INS 1E cells and a stable clone with tetracycline-regulated Munc 18-1 RNA interference.	tet	129-141	syntaxin binding protein 1	Rattus norvegicus	152-161
18212050-5	2008	Here we report the establishment of a tetracycline-controlled EWS/ETS-inducible system in human bone marrow-derived mesenchymal progenitor cells (MPCs).	tet	38-50	EWS RNA binding protein 1	Homo sapiens	62-65
18334552-4	2008	We have generated tetracycline-inducible transgenic lines that carry a minigene of human LMNA under the control of a tet-operon.	tet	18-30	lamin A/C	Homo sapiens	89-93
18447646-3	2008	Using lentivirus (LV)-mediated gene transfer and a tetracycline-controlled trans-repressor (TR), we first established in hES cells a doxycycline (DOX)-inducible expression system of green fluorescent protein (GFP) to probe its reversibility and kinetics.	tet	51-63	ribosome binding protein 1	Homo sapiens	121-124
18272783-4	2008	Parathyroid hormone (PTH) stimulated ERK1/2 phosphorylation by a protein kinase A (PKA)-dependent, but protein kinase C-, cyclic adenosine 5"-monophosphate-, and Rap1-independent pathway in Chinese hamster ovary cells stably transfected with the PTH1R and engineered to express NHERF1 under the control of tetracycline.	tet	306-318	Parathyroid hormone containing protein	Cricetulus griseus	0-19
18272783-4	2008	Parathyroid hormone (PTH) stimulated ERK1/2 phosphorylation by a protein kinase A (PKA)-dependent, but protein kinase C-, cyclic adenosine 5"-monophosphate-, and Rap1-independent pathway in Chinese hamster ovary cells stably transfected with the PTH1R and engineered to express NHERF1 under the control of tetracycline.	tet	306-318	Parathyroid hormone containing protein	Cricetulus griseus	21-24
18413803-10	2008	When UMUC3(Cox-2/Tet) cells overexpressing COX-2 under the control of tetracycline-inducible promoter were treated with celecoxib in modified monolayer cell culture, growth inhibition was found to be associated with changes in the expression of pRb.	tet	70-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	11-16
18413803-10	2008	When UMUC3(Cox-2/Tet) cells overexpressing COX-2 under the control of tetracycline-inducible promoter were treated with celecoxib in modified monolayer cell culture, growth inhibition was found to be associated with changes in the expression of pRb.	tet	70-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	43-48
18413803-10	2008	When UMUC3(Cox-2/Tet) cells overexpressing COX-2 under the control of tetracycline-inducible promoter were treated with celecoxib in modified monolayer cell culture, growth inhibition was found to be associated with changes in the expression of pRb.	tet	70-82	RB transcriptional corepressor 1	Homo sapiens	245-248
18180776-4	2008	Expression of Rev and VSV-G was tightly regulated by the cumate and Tet switches.	tet	68-71	Rev	Human immunodeficiency virus 1	14-17
18366713-7	2008	In response to removal of Tet from growth medium, SfoI was selectively delivered into mitochondria and digested only the wild-type mtDNA but not the mutated rps4.	tet	26-29	ribosomal protein S4 X-linked	Homo sapiens	157-161
18366713-8	2008	Thus one can gain rps4-null cells with only the mutated mtDNA, under the Tet-minus condition.	tet	73-76	ribosomal protein S4 X-linked	Homo sapiens	18-22
18326755-4	2008	METHODS: Transgenic mice carrying the human vitelliform macular dystrophy-2 (VMD2) promoter (P(VMD2))-directed reverse tetracycline-dependent transactivator (rtTA) and the tetracycline-responsive element (TRE)-directed cre were generated.	tet	119-131	bestrophin 1	Homo sapiens	77-81
18326755-4	2008	METHODS: Transgenic mice carrying the human vitelliform macular dystrophy-2 (VMD2) promoter (P(VMD2))-directed reverse tetracycline-dependent transactivator (rtTA) and the tetracycline-responsive element (TRE)-directed cre were generated.	tet	119-131	bestrophin 1	Homo sapiens	95-99
18079274-3	2008	Indeed, the doxycycline-dependent overexpression of constitutively active Akt1 in tetracycline (Tet)-Off PC-12 positive mutants and the exposure of Tet-Off PC-12 wild type to nerve growth factor induced an up-regulation of NCX1 and NCX3 proteins.	tet	82-94	AKT serine/threonine kinase 1	Rattus norvegicus	74-78
18079274-3	2008	Indeed, the doxycycline-dependent overexpression of constitutively active Akt1 in tetracycline (Tet)-Off PC-12 positive mutants and the exposure of Tet-Off PC-12 wild type to nerve growth factor induced an up-regulation of NCX1 and NCX3 proteins.	tet	96-99	AKT serine/threonine kinase 1	Rattus norvegicus	74-78
18079274-6	2008	As expected, in PC-12 Tet-Off wild-type cells MG-132 enhanced NCX3 protein levels.	tet	22-25	solute carrier family 8 member A3	Rattus norvegicus	62-66
18267949-6	2008	We have used a (32)P-postlabelling method to monitor the removal of GpG- and ApG-intrastrand cross links from two human cell models (the 041TR system, in which p53 is regulated by a tetracycline-inducible promoter, together with WI38 fibroblasts and the SV40-transformed derivative VA13) that each differ in p53 status.	tet	182-194	tumor protein p53	Homo sapiens	160-163
18202185-2	2008	We generated transgenic mice to express p25, the N-terminally truncated p35 activator of cdk5, in forebrain under tetracycline control (TET-off).	tet	114-126	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	40-43
18234858-7	2008	Fusion proteins of HMGA1a and the DNA-binding domain of the viral factor EBNA1 or the prokaryotic tetracycline repressor, TetR, can recruit ORC to cognate operator sites forming functional origins of DNA replication.	tet	98-110	high mobility group AT-hook 1	Homo sapiens	19-25
18260137-0	2008	Expression of glucagon receptors in tetracycline-inducible HEK293S GnT1- stable cell lines: an approach toward purification of receptor protein for structural studies.	tet	36-48	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	67-71
17984977-4	2008	We designed two tetracycline-inducible recombinant adenoviruses using the human telomerase reverse transcriptase (hTERT) promoter for transcriptional apoptogene targeting.	tet	16-28	telomerase reverse transcriptase	Homo sapiens	80-112
17984977-4	2008	We designed two tetracycline-inducible recombinant adenoviruses using the human telomerase reverse transcriptase (hTERT) promoter for transcriptional apoptogene targeting.	tet	16-28	telomerase reverse transcriptase	Homo sapiens	114-119
17637751-3	2008	Observations in immunohistochemical analyses, a tetracycline-induced p63 expression system and keratinocyte cultures suggested a physiological link between p63 and MFGE8.	tet	48-60	tumor protein p63	Homo sapiens	69-72
17637751-3	2008	Observations in immunohistochemical analyses, a tetracycline-induced p63 expression system and keratinocyte cultures suggested a physiological link between p63 and MFGE8.	tet	48-60	tumor protein p63	Homo sapiens	156-159
17637751-3	2008	Observations in immunohistochemical analyses, a tetracycline-induced p63 expression system and keratinocyte cultures suggested a physiological link between p63 and MFGE8.	tet	48-60	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	164-169
18184463-8	2008	The secretion peak appeared within the first 72 h. The protein level of IFN-gamma was significantly lower in 300 ng/ml tetracycline hydrochloride-treated marrow stroma cells than in untreated cells [(67.11+/-22.14) pg/1 x 10(7) cells vs. (319.96+/-29.04) pg/1 x 10(7) cells, P&lt;0.001]; its expression was increased when removed tetracycline hydrochloride (P=0.032).	tet	119-145	interferon gamma	Mus musculus	72-81
18184463-8	2008	The secretion peak appeared within the first 72 h. The protein level of IFN-gamma was significantly lower in 300 ng/ml tetracycline hydrochloride-treated marrow stroma cells than in untreated cells [(67.11+/-22.14) pg/1 x 10(7) cells vs. (319.96+/-29.04) pg/1 x 10(7) cells, P&lt;0.001]; its expression was increased when removed tetracycline hydrochloride (P=0.032).	tet	330-356	interferon gamma	Mus musculus	72-81
18184463-10	2008	The mRNA level of IFN-gamma was significantly higher in untreated group than in continuous tetracycline hydrochloride-treated group [(1.5+/-0.7)x10(5) copies .	tet	91-117	interferon gamma	Mus musculus	18-27
18491207-2	2008	In order to further elucidate the role of Akt1 in blood vessel development, a tetracycline-regulated transgenic system was utilized to conditionally activate Akt1 signaling in endothelial cells to examine transcript expression changes associated with angiogenesis in the heart.	tet	78-90	thymoma viral proto-oncogene 1	Mus musculus	158-162
17950691-7	2008	In addition, Yor1p protects cells, although weakly, against tetracycline, verapamil, eosin Y and ethidium bromide.	tet	60-72	ATP-binding cassette transporter YOR1	Saccharomyces cerevisiae S288C	13-18
17989718-7	2008	When these two aspartates were mutated into alanines, more intriguingly, the apoptosis-amplified action of AML1-ETO induction completely disappeared, while inducible expression of the caspase-3-cleaved 70 kDa fragment of AML1-ETO after tetracycline removal is sufficient to enhance apoptotic sensitivity.	tet	236-248	RUNX family transcription factor 1	Homo sapiens	107-111
17989718-7	2008	When these two aspartates were mutated into alanines, more intriguingly, the apoptosis-amplified action of AML1-ETO induction completely disappeared, while inducible expression of the caspase-3-cleaved 70 kDa fragment of AML1-ETO after tetracycline removal is sufficient to enhance apoptotic sensitivity.	tet	236-248	caspase 3	Homo sapiens	184-193
18260137-9	2008	To obtain adequate amounts of receptor protein for structural studies, a tetracycline-inducible HEK293S GnT1(-) cell line that stably expresses human GR at high-levels was developed.	tet	73-85	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	104-108
18260137-9	2008	To obtain adequate amounts of receptor protein for structural studies, a tetracycline-inducible HEK293S GnT1(-) cell line that stably expresses human GR at high-levels was developed.	tet	73-85	glucagon receptor	Homo sapiens	150-152
18093939-3	2007	An shRNA-mir cassette is targeted near the constitutively active HPRT locus under a tetracycline (tet)-regulatable promoter through Cre-mediated site-specific recombination.	tet	84-96	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	65-69
17611578-4	2008	Using a tetracycline inducible system, we show that the postnatal expression of Edn3 is required to maintain these dermal melanocytes, and that early expression of the Edn3 transgene is important to the onset of the hyperpigmentation phenotype.	tet	8-20	endothelin 3	Mus musculus	80-84
18603120-7	2008	In this chapter, we describe the use of RNA interference (siRNA) technology and tetracycline-inducible expression of PKC isozymes to study their function in apoptosis.	tet	80-92	proline rich transmembrane protein 2	Homo sapiens	117-120
18322654-5	2008	The expression of STGC3 as induced by doxycycline (Dox) via a tetracycline (Tet)-regulated system in human nasopharyngeal carcinoma cell line CNE2 was also established, and the effect of STGC3 restoration on the biological behavior of CNE2 was observed.	tet	62-74	STGC3	Homo sapiens	18-23
18322654-5	2008	The expression of STGC3 as induced by doxycycline (Dox) via a tetracycline (Tet)-regulated system in human nasopharyngeal carcinoma cell line CNE2 was also established, and the effect of STGC3 restoration on the biological behavior of CNE2 was observed.	tet	76-79	STGC3	Homo sapiens	18-23
18003626-5	2008	Two cell models were selected: 041 TR fibroblasts in which the expression of p53 is regulated by a tetracycline-inducible promoter, and WI38 primary lung fibroblasts together with their isogenic derivative VA13, in which p53 is abrogated post-translationally by SV40 transformation.	tet	99-111	tumor protein p53	Homo sapiens	77-80
18333801-3	2008	Moreover, to regulate overexpression of isoform 165 of VEGF and its effect on healing, we introduced a tetracycline (TC)-inducible gene switch in the expression plasmid.	tet	103-115	vascular endothelial growth factor A	Homo sapiens	55-59
18333801-3	2008	Moreover, to regulate overexpression of isoform 165 of VEGF and its effect on healing, we introduced a tetracycline (TC)-inducible gene switch in the expression plasmid.	tet	117-119	vascular endothelial growth factor A	Homo sapiens	55-59
18093939-3	2007	An shRNA-mir cassette is targeted near the constitutively active HPRT locus under a tetracycline (tet)-regulatable promoter through Cre-mediated site-specific recombination.	tet	84-87	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	65-69
18056394-9	2007	Finally, endothelial-specific tetracycline-inducible expression of E-selectin at the BBB in transgenic C57BL/6 mice did not alter the development of EAE.	tet	30-42	selectin, endothelial cell	Mus musculus	67-77
17921332-3	2007	Here we generated cardiac myocyte-specific transgenic mice using a tetracycline-inducible system to permit controlled expression of dominant negative PKCalpha in the heart.	tet	67-79	protein kinase C, alpha	Mus musculus	150-158
17884816-5	2007	Using Chinese hamster ovary cells expressing the PTH1R, where NHERF1 expression could be induced by tetracycline, NHERF1 inhibited PTH1R endocytosis and delayed PTH1R recycling.	tet	100-112	parathyroid hormone/parathyroid hormone-related peptide receptor	Cricetulus griseus	49-54
17884816-5	2007	Using Chinese hamster ovary cells expressing the PTH1R, where NHERF1 expression could be induced by tetracycline, NHERF1 inhibited PTH1R endocytosis and delayed PTH1R recycling.	tet	100-112	SLC9A3 regulator 1	Homo sapiens	62-68
17884816-5	2007	Using Chinese hamster ovary cells expressing the PTH1R, where NHERF1 expression could be induced by tetracycline, NHERF1 inhibited PTH1R endocytosis and delayed PTH1R recycling.	tet	100-112	SLC9A3 regulator 1	Homo sapiens	114-120
17884816-5	2007	Using Chinese hamster ovary cells expressing the PTH1R, where NHERF1 expression could be induced by tetracycline, NHERF1 inhibited PTH1R endocytosis and delayed PTH1R recycling.	tet	100-112	parathyroid hormone/parathyroid hormone-related peptide receptor	Cricetulus griseus	131-136
17884816-5	2007	Using Chinese hamster ovary cells expressing the PTH1R, where NHERF1 expression could be induced by tetracycline, NHERF1 inhibited PTH1R endocytosis and delayed PTH1R recycling.	tet	100-112	parathyroid hormone/parathyroid hormone-related peptide receptor	Cricetulus griseus	131-136
18045952-8	2007	In order to understand implications of SOCS-3 regulation by androgen, we used SOCS-3-negative LNCaP-IL-6 cells and stably transfected them with a tetracycline-responsive SOCS-3 Tet-On plasmid.	tet	146-158	suppressor of cytokine signaling 3	Homo sapiens	39-45
17991717-4	2007	We have developed a tetracycline-regulated CD44s (standard form) system in the weakly metastatic breast cancer cell MCF7, which exhibits low endogenous expression of CD44 and generated a new cell line, MCF7F-B5.	tet	20-32	CD44 antigen	Mus musculus	43-47
17991717-4	2007	We have developed a tetracycline-regulated CD44s (standard form) system in the weakly metastatic breast cancer cell MCF7, which exhibits low endogenous expression of CD44 and generated a new cell line, MCF7F-B5.	tet	20-32	CD44 antigen	Mus musculus	166-170
18045952-8	2007	In order to understand implications of SOCS-3 regulation by androgen, we used SOCS-3-negative LNCaP-IL-6 cells and stably transfected them with a tetracycline-responsive SOCS-3 Tet-On plasmid.	tet	146-158	interleukin 6	Homo sapiens	100-104
17855347-5	2007	We generated Dppa4-overexpressing ES cells under the control of tetracycline.	tet	64-76	developmental pluripotency associated 4	Mus musculus	13-18
17913716-5	2007	Tetracycline-dependent repression of CgAUS1 in the tet-AUS1 strain was used to determine the fluconazole susceptibility of CgAUS1 in the presence and absence of serum.	tet	0-12	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	39-43
17901358-6	2007	Induction of the GSK-3beta transgene in tetracycline-regulatable wild-type GSK-3beta mice induced left ventricular dysfunction and premature death, accompanied by increases in apoptosis and fibrosis.	tet	40-52	glycogen synthase kinase 3 beta	Mus musculus	17-26
17901358-6	2007	Induction of the GSK-3beta transgene in tetracycline-regulatable wild-type GSK-3beta mice induced left ventricular dysfunction and premature death, accompanied by increases in apoptosis and fibrosis.	tet	40-52	glycogen synthase kinase 3 beta	Mus musculus	75-84
17941046-0	2007	Targeting reverse tetracycline-dependent transactivator to murine mammary epithelial cells that express the progesterone receptor.	tet	18-30	progesterone receptor	Mus musculus	108-129
17986321-8	2007	METHODS: We established a TAC2 mouse mammary epithelial cell line with tetracycline-inducible psoriasin expression (Tet-Off).	tet	71-83	tachykinin 2	Mus musculus	26-30
17986321-18	2007	Finally, in TAC2 cells with tetracycline-induced psoriasin expression, we observed the increased viability of psoriasin-expressing cells after IFN-gamma treatment.	tet	28-40	tachykinin precursor 1	Homo sapiens	12-16
17986321-18	2007	Finally, in TAC2 cells with tetracycline-induced psoriasin expression, we observed the increased viability of psoriasin-expressing cells after IFN-gamma treatment.	tet	28-40	interferon gamma	Homo sapiens	143-152
17685427-3	2007	We have established cell lines in which expression of wild-type Sp3 or a serine 73 to alanine (S73A) mutant is controlled by tetracycline.	tet	125-137	Sp3 transcription factor	Homo sapiens	64-67
17569023-9	2007	Tetracycline-inducible FGF-AS b expression in stably transfected human Seg-1 esophageal adenocarcinoma cells resulted in a significant suppression of steady state FGF-2 mRNA content and cell proliferation.	tet	0-12	nudix hydrolase 6	Homo sapiens	23-29
17569023-9	2007	Tetracycline-inducible FGF-AS b expression in stably transfected human Seg-1 esophageal adenocarcinoma cells resulted in a significant suppression of steady state FGF-2 mRNA content and cell proliferation.	tet	0-12	fibroblast growth factor 2	Homo sapiens	163-168
17826772-2	2007	In order to identify ATOH1 target genes, we performed a genome-wide expression profiling analysis in cells expressing ATOH1 under the control of a tetracycline-off system and found that HES6 expression is induced by ATOH1.	tet	147-159	atonal bHLH transcription factor 1	Homo sapiens	21-26
17826772-2	2007	In order to identify ATOH1 target genes, we performed a genome-wide expression profiling analysis in cells expressing ATOH1 under the control of a tetracycline-off system and found that HES6 expression is induced by ATOH1.	tet	147-159	atonal bHLH transcription factor 1	Homo sapiens	118-123
17826772-2	2007	In order to identify ATOH1 target genes, we performed a genome-wide expression profiling analysis in cells expressing ATOH1 under the control of a tetracycline-off system and found that HES6 expression is induced by ATOH1.	tet	147-159	hes family bHLH transcription factor 6	Homo sapiens	186-190
17826772-2	2007	In order to identify ATOH1 target genes, we performed a genome-wide expression profiling analysis in cells expressing ATOH1 under the control of a tetracycline-off system and found that HES6 expression is induced by ATOH1.	tet	147-159	atonal bHLH transcription factor 1	Homo sapiens	118-123
17669625-6	2007	HEK293 cells bearing a tetracycline-inducible IB1 construct showed a specific increase of the short JNK endogenous splice variants in the presence of tetracycline.	tet	23-35	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	46-49
17669625-6	2007	HEK293 cells bearing a tetracycline-inducible IB1 construct showed a specific increase of the short JNK endogenous splice variants in the presence of tetracycline.	tet	23-35	mitogen-activated protein kinase 8	Homo sapiens	100-103
17669625-6	2007	HEK293 cells bearing a tetracycline-inducible IB1 construct showed a specific increase of the short JNK endogenous splice variants in the presence of tetracycline.	tet	150-162	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	46-49
17669625-6	2007	HEK293 cells bearing a tetracycline-inducible IB1 construct showed a specific increase of the short JNK endogenous splice variants in the presence of tetracycline.	tet	150-162	mitogen-activated protein kinase 8	Homo sapiens	100-103
17698063-11	2007	Intraperitoneal injection of the tetracycline derivative, minocycline, beginning 6 h after ICH ameliorated the damage by reducing microvessel loss, extravasation of plasma proteins and edema; decreasing TNFalpha and MMP-12 expression; and reducing the numbers of TNFalpha-positive cells and neutrophils in the brain.	tet	33-45	tumor necrosis factor	Rattus norvegicus	203-211
17698063-11	2007	Intraperitoneal injection of the tetracycline derivative, minocycline, beginning 6 h after ICH ameliorated the damage by reducing microvessel loss, extravasation of plasma proteins and edema; decreasing TNFalpha and MMP-12 expression; and reducing the numbers of TNFalpha-positive cells and neutrophils in the brain.	tet	33-45	matrix metallopeptidase 12	Rattus norvegicus	216-222
17698063-11	2007	Intraperitoneal injection of the tetracycline derivative, minocycline, beginning 6 h after ICH ameliorated the damage by reducing microvessel loss, extravasation of plasma proteins and edema; decreasing TNFalpha and MMP-12 expression; and reducing the numbers of TNFalpha-positive cells and neutrophils in the brain.	tet	33-45	tumor necrosis factor	Rattus norvegicus	263-271
17898225-3	2007	Using tetracycline-inducible expression of brain-derived neurotrophic factor by genetically modified fibroblasts, we were able to extensively and significantly turn growth factor expression "on" or "off" in vitro and in vivo within sites of SCI.	tet	6-18	brain derived neurotrophic factor	Homo sapiens	43-76
17561413-0	2007	High-level expression and purification of the human bradykinin B(2) receptor in a tetracycline-inducible stable HEK293S cell line.	tet	82-94	bradykinin receptor B2	Homo sapiens	63-76
17561413-7	2007	However, the decrease of expression level with cell passages led us to express the B(2) receptor in a HEK293S tetracycline-inducible stable cell line.	tet	110-122	bradykinin receptor B2	Homo sapiens	83-96
17561413-8	2007	Induction of expression of the B(2) receptor with tetracycline and sodium butyrate led to a level of 100pmol/mg of membrane protein, which is the highest level reported so far for this receptor.	tet	50-62	bradykinin receptor B2	Homo sapiens	31-44
17704116-6	2007	The tetracycline resistance regions were closely related and consisted of the tet(H) gene and its repressor gene tetR.	tet	4-16	TetR	Actinobacillus pleuropneumoniae	113-117
17609287-6	2007	To determine whether this induction has functional consequences on transepithelial Na+ current, we generated clonal CCD cell lines that express a tetracycline-inducible MLPH.	tet	146-158	melanophilin	Mus musculus	169-173
17785852-6	2007	Using a tetracycline-regulated transgene in HeLa cells, we determined that IL-17 treatment alone promoted stabilization of KC mRNA in the absence of TNF-alpha.	tet	8-20	interleukin 17A	Homo sapiens	75-80
17928728-7	2007	Classification and regression trees indicated that the root surfaces treated with 125 microg b-FGF and previously conditioned with tetracycline-HCl or EDTA presented a morphology more suggestive of cellular adhesion and viability (P = 0.004).	tet	131-147	fibroblast growth factor 2	Homo sapiens	93-98
17883895-7	2007	Antioxidant enzymes, superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase, showed a small but significant decrease in the pancreas of the rats treated with 50 mg kg(-1) tetracycline.	tet	197-209	glutathione-disulfide reductase	Rattus norvegicus	67-88
17883895-7	2007	Antioxidant enzymes, superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase, showed a small but significant decrease in the pancreas of the rats treated with 50 mg kg(-1) tetracycline.	tet	197-209	catalase	Rattus norvegicus	93-101
17398168-2	2007	To determine whether the transcription level is directly correlated with the degree of genomic instability, we have developed a tetracycline-regulated LYS2 reporter system to modulate the transcription level over a broad range in Saccharomyces cerevisiae.	tet	128-140	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	151-155
17660712-4	2007	Using the tetracycline system to allow conditional and concomitant TPM3-ALK and luciferase expression, we have developed a unique transplant model for bioluminescent TPM3-ALK-induced fibroblastic tumors in athymic nude mice.	tet	10-22	tropomyosin 3, gamma	Mus musculus	67-71
17825229-8	2007	RESULTS: While U937/PLZF cells were incubated in tetracycline-withdrawn medium, the expression of PLZF-RARalpha; protein increased.	tet	49-61	zinc finger and BTB domain containing 16	Homo sapiens	20-24
17825229-8	2007	RESULTS: While U937/PLZF cells were incubated in tetracycline-withdrawn medium, the expression of PLZF-RARalpha; protein increased.	tet	49-61	zinc finger and BTB domain containing 16	Homo sapiens	98-102
17825229-8	2007	RESULTS: While U937/PLZF cells were incubated in tetracycline-withdrawn medium, the expression of PLZF-RARalpha; protein increased.	tet	49-61	retinoic acid receptor alpha	Homo sapiens	103-111
17686474-3	2007	Rat-1 cells were produced to stably express mPer2 promoter-driven luciferase reporter, in which mCry1 was overexpressed under a tetracycline-dependent gene expression (Tet-On) system.	tet	128-140	cryptochrome 1 (photolyase-like)	Mus musculus	96-101
17501721-3	2007	We have generated cell lines expressing NOX4 upon tetracycline induction.	tet	50-62	NADPH oxidase 4	Homo sapiens	40-44
17501721-4	2007	Tetracycline induced a rapid increase in NOX4 mRNA (1 h) followed closely (2 h) by a release of ROS.	tet	0-12	NADPH oxidase 4	Homo sapiens	41-45
17501721-5	2007	Upon tetracycline withdrawal, NOX4 mRNA levels and ROS release decreased rapidly (&lt;24 h).	tet	5-17	NADPH oxidase 4	Homo sapiens	30-34
17431790-4	2007	The effect of acute acidification on heat-induced apoptosis was examined in a human T-cell line with tetracycline-regulated Hsp70 expression.	tet	101-113	heat shock protein family A (Hsp70) member 4	Homo sapiens	124-129
17660712-4	2007	Using the tetracycline system to allow conditional and concomitant TPM3-ALK and luciferase expression, we have developed a unique transplant model for bioluminescent TPM3-ALK-induced fibroblastic tumors in athymic nude mice.	tet	10-22	anaplastic lymphoma kinase	Mus musculus	72-75
17660712-4	2007	Using the tetracycline system to allow conditional and concomitant TPM3-ALK and luciferase expression, we have developed a unique transplant model for bioluminescent TPM3-ALK-induced fibroblastic tumors in athymic nude mice.	tet	10-22	tropomyosin 3, gamma	Mus musculus	166-170
17660712-4	2007	Using the tetracycline system to allow conditional and concomitant TPM3-ALK and luciferase expression, we have developed a unique transplant model for bioluminescent TPM3-ALK-induced fibroblastic tumors in athymic nude mice.	tet	10-22	anaplastic lymphoma kinase	Mus musculus	171-174
17237909-1	2007	This phase II study evaluated the antitumor activity of the tetracycline analog COL-3, a potent inhibitor of metalloproteinases (MMPs), particularly MMP-2 and MMP-9, on a continuous oral schedule at a dose of 50 mg/m2 daily in patients with advanced and/or metastatic soft tissue sarcoma (STS).	tet	60-72	matrix metallopeptidase 2	Homo sapiens	129-133
17560009-1	2007	OBJECTIVE: We previously showed that Vav promoter-tetracycline transactivator (Vav-tTA)-driven tetracycline-regulated element (TRE)-NRAS(V12) expression resulted in mastocytosis development in mice.	tet	50-62	vav 1 oncogene	Mus musculus	37-40
17560009-1	2007	OBJECTIVE: We previously showed that Vav promoter-tetracycline transactivator (Vav-tTA)-driven tetracycline-regulated element (TRE)-NRAS(V12) expression resulted in mastocytosis development in mice.	tet	50-62	vav 1 oncogene	Mus musculus	79-82
17560009-1	2007	OBJECTIVE: We previously showed that Vav promoter-tetracycline transactivator (Vav-tTA)-driven tetracycline-regulated element (TRE)-NRAS(V12) expression resulted in mastocytosis development in mice.	tet	50-62	neuroblastoma ras oncogene	Mus musculus	132-136
17237909-1	2007	This phase II study evaluated the antitumor activity of the tetracycline analog COL-3, a potent inhibitor of metalloproteinases (MMPs), particularly MMP-2 and MMP-9, on a continuous oral schedule at a dose of 50 mg/m2 daily in patients with advanced and/or metastatic soft tissue sarcoma (STS).	tet	60-72	matrix metallopeptidase 2	Homo sapiens	149-154
17603790-5	2007	Reporter transgene expression in mice expressing these constructs is highly specific for CD4+ cells, is strictly dependent on the tetracycline derivative doxycycline, and can be regulated by up to five logs depending on the doxycycline concentration.	tet	130-142	CD4 antigen	Mus musculus	89-92
17464091-4	2007	To better define the function of Notch in both normal and neoplastic hematopoiesis, a tetracycline-inducible system regulating expression of a ligand-independent, constitutively active form of Notch1 was introduced into murine E14Tg2a embryonic stem cells.	tet	86-98	notch 1	Mus musculus	193-199
17540497-0	2007	Ca2+ and Mg2+ bind tetracycline with distinct stoichiometries and linked deprotonation.	tet	19-31	mucin 7, secreted	Homo sapiens	9-12
17540497-1	2007	Tetracycline depends on divalent metal ions for its biological function, but its multiple ionization states, conformations, and tautomers at varying solution conditions complicate its ion-binding equilibria, and the stoichiometry of the biologically relevant Ca2+ or Mg2+ complexes has not been clear.	tet	0-12	mucin 7, secreted	Homo sapiens	267-270
17540497-2	2007	Isothermal titration calorimetry was used in the present work to study Ca2+ and Mg2+ binding to tetracycline.	tet	96-108	mucin 7, secreted	Homo sapiens	80-83
17666873-4	2007	To analyze the detail functions of human PPARs, we previously established tetracycline-regulated human hepatoblastoma cell lines that can be induced to express each human PPAR subtype.	tet	74-86	peroxisome proliferator activated receptor alpha	Homo sapiens	41-45
21603516-5	2007	EXPERIMENTAL DESIGN: The p53-null human erythroleukemia cell line, K-562, was stably transfected with a tetracycline-repressible p53 expression construct (p53/pUHD10-3).	tet	104-116	tumor protein p53	Homo sapiens	25-28
17708358-5	2007	In addition, because plasmid-mediated resistance is often found in tetracycline-treated cattle, SILA compound 421 may have potential as an adjunct during the time that the cattle are maintained on tetracycline prior to slaughter.	tet	197-209	heavy metal efflux pump	Escherichia coli	96-100
17572676-4	2007	Transgenic mice harboring a tet-responsive RNA polymerase II promoter driving a microRNA-based short hairpin RNA targeting the tumor suppressor Trp53 reversibly express short hairpin RNA when crossed with existing mouse strains expressing general or tissue-specific "tet-on" or "tet-off" transactivators.	tet	28-31	transformation related protein 53	Mus musculus	144-149
17572676-4	2007	Transgenic mice harboring a tet-responsive RNA polymerase II promoter driving a microRNA-based short hairpin RNA targeting the tumor suppressor Trp53 reversibly express short hairpin RNA when crossed with existing mouse strains expressing general or tissue-specific "tet-on" or "tet-off" transactivators.	tet	267-270	transformation related protein 53	Mus musculus	144-149
17572676-4	2007	Transgenic mice harboring a tet-responsive RNA polymerase II promoter driving a microRNA-based short hairpin RNA targeting the tumor suppressor Trp53 reversibly express short hairpin RNA when crossed with existing mouse strains expressing general or tissue-specific "tet-on" or "tet-off" transactivators.	tet	267-270	transformation related protein 53	Mus musculus	144-149
21603516-5	2007	EXPERIMENTAL DESIGN: The p53-null human erythroleukemia cell line, K-562, was stably transfected with a tetracycline-repressible p53 expression construct (p53/pUHD10-3).	tet	104-116	tumor protein p53	Homo sapiens	129-132
21603516-5	2007	EXPERIMENTAL DESIGN: The p53-null human erythroleukemia cell line, K-562, was stably transfected with a tetracycline-repressible p53 expression construct (p53/pUHD10-3).	tet	104-116	tumor protein p53	Homo sapiens	129-132
21603516-6	2007	p53 protein in these cells is expressed in the absence of tetracycline but down-regulated upon tetracycline treatment.	tet	58-70	tumor protein p53	Homo sapiens	0-3
21603516-6	2007	p53 protein in these cells is expressed in the absence of tetracycline but down-regulated upon tetracycline treatment.	tet	95-107	tumor protein p53	Homo sapiens	0-3
17317860-3	2007	To address this issue, we expressed oncogenic K-ras (K-ras(G12D)) from its endogenous promoter using a tetracycline-inducible system.	tet	103-115	KRAS proto-oncogene, GTPase	Homo sapiens	46-51
17594499-7	2007	Strong regulation of gene expression was realized by fusion of the VP16 to a tetracycline repressor with binding of the fusion protein to a flanking tetracycline operator and further enhanced by auto-regulated expression of its fusion gene within a bicistronic promoter construct.	tet	77-89	host cell factor C1	Homo sapiens	67-71
17594499-7	2007	Strong regulation of gene expression was realized by fusion of the VP16 to a tetracycline repressor with binding of the fusion protein to a flanking tetracycline operator and further enhanced by auto-regulated expression of its fusion gene within a bicistronic promoter construct.	tet	149-161	host cell factor C1	Homo sapiens	67-71
17317860-3	2007	To address this issue, we expressed oncogenic K-ras (K-ras(G12D)) from its endogenous promoter using a tetracycline-inducible system.	tet	103-115	KRAS proto-oncogene, GTPase	Homo sapiens	53-58
17535850-4	2007	On this basis, we established an ES cell differentiation system with the tetracycline-regulated expression of Nodal.	tet	73-85	nodal growth differentiation factor	Homo sapiens	110-115
17466266-1	2007	We established genetically engineered ES (ZHTc6-MyoD) cells that harbor a tetracycline-regulated expression vector encoding myogenic transcriptional factor MyoD, for the therapy of muscle diseases, especially Duchenne muscular dystrophy (DMD).	tet	74-86	myogenic differentiation 1	Mus musculus	48-52
17466266-1	2007	We established genetically engineered ES (ZHTc6-MyoD) cells that harbor a tetracycline-regulated expression vector encoding myogenic transcriptional factor MyoD, for the therapy of muscle diseases, especially Duchenne muscular dystrophy (DMD).	tet	74-86	myogenic differentiation 1	Mus musculus	156-160
17466266-2	2007	Almost all the ZHTc6-MyoD cells were induced into muscle lineage after removal of tetracycline.	tet	82-94	myogenic differentiation 1	Mus musculus	21-25
17553164-4	2007	In the present study, we generated tetracycline-inducible LNCaP-DDC prostate cancer stable cells to identify DDC downstream target genes by oligonucleotide microarray analysis.	tet	35-47	dopa decarboxylase	Homo sapiens	64-67
17510631-4	2007	Here, we have generated transgenic mice with conditional (tetracycline system) expression of dominant-negative-GSK-3 as an alternative genetic approach to predict the outcome of chronic GSK-3 inhibition, either per se, or in combination with mouse models of disease.	tet	58-70	glycogen synthase kinase 3 beta	Mus musculus	111-116
17553164-4	2007	In the present study, we generated tetracycline-inducible LNCaP-DDC prostate cancer stable cells to identify DDC downstream target genes by oligonucleotide microarray analysis.	tet	35-47	dopa decarboxylase	Homo sapiens	109-112
17287109-5	2007	To this end, we generated PC12 derived cell lines that express the interfering mutant of Shp2 under a tetracycline-inducible promoter.	tet	102-114	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	89-93
17672209-5	2007	RESULTS: Protease-resistant PrP was significantly reduced in or removed from the preparations treated with tetracycline in a dose-dependant manner.	tet	107-119	major prion protein	Mesocricetus auratus	28-31
17509140-5	2007	Transduction of human prostate cancer cell lines with this virus and with a virus containing a reverse-tetracycline transactivator (rt-TA) resulted in a stable transgene which induced both uPAR and DsRed proteins in a dose-responsive fashion upon stimulation with doxycycline.	tet	103-115	plasminogen activator, urokinase receptor	Homo sapiens	189-193
17525799-4	2007	Transgenic mice expressing the reverse tetracycline-responsive transactivator (rtTA) gene under the control of the rat elastase promoter were generated to mediate acinar cell-specific expression of IKK2 alleles.	tet	39-51	inhibitor of nuclear factor kappa B kinase subunit beta	Rattus norvegicus	198-202
17571923-8	2007	The original Indy line with long-lived males is infected by the cytoplasmic symbiont Wolbachia, and the longevity of Indy males disappeared after tetracycline clearance of this endosymbiont.	tet	146-158	I'm not dead yet	Drosophila melanogaster	13-17
17571923-8	2007	The original Indy line with long-lived males is infected by the cytoplasmic symbiont Wolbachia, and the longevity of Indy males disappeared after tetracycline clearance of this endosymbiont.	tet	146-158	I'm not dead yet	Drosophila melanogaster	117-121
17258428-2	2007	Expression of the wt p53 gene was regulated by a system, which allowed or blocked expression p53 by absence or presence of tetracycline in the culture media.	tet	123-135	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	21-24
17258428-2	2007	Expression of the wt p53 gene was regulated by a system, which allowed or blocked expression p53 by absence or presence of tetracycline in the culture media.	tet	123-135	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	93-96
17258428-3	2007	Western blot analyses confirmed an inducible and tetracycline-dependent expression of the wt p53 protein.	tet	49-61	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	93-96
17374541-1	2007	A 16-residue peptide, called Tip, induces the tetracycline repressor TetR as efficiently as the antibiotic tetracycline when fused to the N or C terminus of another protein.	tet	46-58	TOR signaling pathway regulator	Homo sapiens	29-32
17493262-9	2007	Transgenes encoding luciferase, I-SceI endonuclease or Rad52 were then inserted by SSR at a LoxP site adjacent to the GFP gene resulting stringent tet-regulated transgene expression.	tet	147-150	RAD52 homolog, DNA repair protein	Homo sapiens	55-60
17475880-2	2007	We investigated whether NF-kappaB pathway signaling in airway epithelium could decisively impact inflammatory phenotypes in the lungs by using a tetracycline-inducible system to achieve selective NF-kappaB activation or inhibition in vivo.	tet	145-157	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	196-205
17374541-1	2007	A 16-residue peptide, called Tip, induces the tetracycline repressor TetR as efficiently as the antibiotic tetracycline when fused to the N or C terminus of another protein.	tet	107-119	TOR signaling pathway regulator	Homo sapiens	29-32
17374541-4	2007	Peptide induction ultimately results in the same movements of DNA reading heads, but Tip accomplishes this by very different molecular interactions from tetracycline involving important contacts to the TetR surface.	tet	153-165	TOR signaling pathway regulator	Homo sapiens	85-88
17276396-3	2007	The modified TRE-mouse U6 promoter can be activated by a Tet-on version tetracycline-regulated artificial activator rTetOct which was constructed by fusing the rtTA DNA binding domain with the Oct-1 POU activation domain.	tet	72-84	POU domain, class 2, transcription factor 1	Mus musculus	193-198
17218383-3	2007	To evaluate which features of this anemia can be attributed to hepcidin, we have generated mice carrying a tetracycline-regulated hepcidin transgene.	tet	107-119	hepcidin antimicrobial peptide	Mus musculus	130-138
17353219-8	2007	The 49 rmtB-positive isolates showed resistance to ampicillin, tetracycline and trimethoprim and also carried a bla(TEM) gene.	tet	63-75	16S rRNA methylase RmtB	Escherichia coli	7-11
17116388-5	2007	STAT1 overexpression under the control of a tetracycline-dependent promoter revealed a close correlation between STAT1 expression and activation, the biological effects of IFN-gamma (growth inhibition, induction of apoptosis), and target gene expression.	tet	44-56	signal transducer and activator of transcription 1	Rattus norvegicus	0-5
17116388-5	2007	STAT1 overexpression under the control of a tetracycline-dependent promoter revealed a close correlation between STAT1 expression and activation, the biological effects of IFN-gamma (growth inhibition, induction of apoptosis), and target gene expression.	tet	44-56	signal transducer and activator of transcription 1	Rattus norvegicus	113-118
17116388-5	2007	STAT1 overexpression under the control of a tetracycline-dependent promoter revealed a close correlation between STAT1 expression and activation, the biological effects of IFN-gamma (growth inhibition, induction of apoptosis), and target gene expression.	tet	44-56	interferon gamma	Rattus norvegicus	172-181
17127713-4	2007	To address this, we employed H1299 lung cancer cells engineered for tetracycline-inducible overexpression of the post-transcriptional regulator iron regulatory protein 1 (IRP1).	tet	68-80	aconitase 1	Homo sapiens	144-169
17127713-4	2007	To address this, we employed H1299 lung cancer cells engineered for tetracycline-inducible overexpression of the post-transcriptional regulator iron regulatory protein 1 (IRP1).	tet	68-80	aconitase 1	Homo sapiens	171-175
17304540-1	2007	We targeted the reverse tetracycline controlled transactivator (rtTA) to the Foxa2 locus (Foxa2(ITA)) to generate a system for regulating Cre-recombinase activity within Foxa2 expression domains, including the endoderm, notochord, and floor plate of early mouse embryos.	tet	24-36	forkhead box A2	Mus musculus	90-100
17304540-1	2007	We targeted the reverse tetracycline controlled transactivator (rtTA) to the Foxa2 locus (Foxa2(ITA)) to generate a system for regulating Cre-recombinase activity within Foxa2 expression domains, including the endoderm, notochord, and floor plate of early mouse embryos.	tet	24-36	forkhead box A2	Mus musculus	90-95
17261592-6	2007	Furthermore, we generated transgenic mice containing a tetracycline-inducible Foxf1 DN transgene.	tet	55-67	forkhead box F1	Mus musculus	78-83
17276988-5	2007	The relationship was further elucidated by the establishment of tetracycline-inducible expression of constitutive Stat3 mutant (Stat3-C) in MDCK cells or expression of dominant negative Stat3 (Stat3-D) stable cell lines (MDCK and NMuMG).	tet	64-76	signal transducer and activator of transcription 3	Canis lupus familiaris	114-119
17276988-5	2007	The relationship was further elucidated by the establishment of tetracycline-inducible expression of constitutive Stat3 mutant (Stat3-C) in MDCK cells or expression of dominant negative Stat3 (Stat3-D) stable cell lines (MDCK and NMuMG).	tet	64-76	signal transducer and activator of transcription 3	Canis lupus familiaris	128-133
17276988-5	2007	The relationship was further elucidated by the establishment of tetracycline-inducible expression of constitutive Stat3 mutant (Stat3-C) in MDCK cells or expression of dominant negative Stat3 (Stat3-D) stable cell lines (MDCK and NMuMG).	tet	64-76	signal transducer and activator of transcription 3	Canis lupus familiaris	128-133
17254749-4	2007	To characterize this family of E3 ligases in intact cells, we generated a cell line with tetracycline-inducible expression of a dominant-negative mutant of the Nedd8-conjugating enzyme Ubc12, a reported inhibitor of cullin neddylation.	tet	89-101	NEDD8 ubiquitin like modifier	Homo sapiens	160-165
17254749-4	2007	To characterize this family of E3 ligases in intact cells, we generated a cell line with tetracycline-inducible expression of a dominant-negative mutant of the Nedd8-conjugating enzyme Ubc12, a reported inhibitor of cullin neddylation.	tet	89-101	ubiquitin conjugating enzyme E2 M	Homo sapiens	185-190
17254749-4	2007	To characterize this family of E3 ligases in intact cells, we generated a cell line with tetracycline-inducible expression of a dominant-negative mutant of the Nedd8-conjugating enzyme Ubc12, a reported inhibitor of cullin neddylation.	tet	89-101	CDK2 associated cullin domain 1	Homo sapiens	216-222
17254606-4	2007	RESULTS: By topically applying tetracycline in wound chambers at various concentrations or at different time points post-transplantation, the levels and timing of hEGF expression in transplanted wounds could be reversibly regulated by tetracycline.	tet	31-43	epidermal growth factor	Homo sapiens	163-167
17254606-4	2007	RESULTS: By topically applying tetracycline in wound chambers at various concentrations or at different time points post-transplantation, the levels and timing of hEGF expression in transplanted wounds could be reversibly regulated by tetracycline.	tet	235-247	epidermal growth factor	Homo sapiens	163-167
17254606-7	2007	CONCLUSIONS: Basal circulating hEGF was undetectable and induced up to at least 1,500-fold after administration of tetracycline.	tet	115-127	epidermal growth factor	Homo sapiens	31-35
17254606-8	2007	Furthermore, the timing and duration of hEGF expression could be finely adjusted by the presence or the absence of tetracycline in the drinking water.	tet	115-127	epidermal growth factor	Homo sapiens	40-44
17146594-6	2007	To further evaluate the function of CYP2E1, the CYP2E1 was stably expressed in the cell line NIH 3T3/rtTA under a tetracycline-controlled transactivator.	tet	114-126	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	48-54
17270300-3	2007	Here, we established a versatile mouse line, mGluR1 conditional knockout (cKO) mice using the tetracycline-controlled gene expression system to understand the roles of mGluR1 in the adult brain.	tet	94-106	glutamate receptor, metabotropic 1	Mus musculus	45-51
17322171-8	2007	We have previously shown in focal adhesion kinase null cells, that tetracycline induced expression of focal adhesion kinase upregulated expression of LPP(2) and now show upregulation of palladin, and paired-related homeobox gene-1 protein.	tet	67-79	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	150-153
17322171-8	2007	We have previously shown in focal adhesion kinase null cells, that tetracycline induced expression of focal adhesion kinase upregulated expression of LPP(2) and now show upregulation of palladin, and paired-related homeobox gene-1 protein.	tet	67-79	palladin, cytoskeletal associated protein	Homo sapiens	186-194
17374729-6	2007	Likewise, ablation of the hPar1 gene in a tetracycline-inducible hPar1 system leads to apoptosis in immature blood vessels, whereas mature vessels were unaffected.	tet	42-54	coagulation factor II thrombin receptor	Homo sapiens	26-31
17363597-7	2007	Furthermore, using the H1299-HW24 cells expressing wild-type p53 under a tetracycline-regulated promoter, the p53-MDM2 oscillation was observed only when p53 levels were in a specific range, and DNA damage was found to be necessary for triggering the p53-MDM2 oscillation.	tet	73-85	tumor protein p53	Homo sapiens	61-64
17363597-7	2007	Furthermore, using the H1299-HW24 cells expressing wild-type p53 under a tetracycline-regulated promoter, the p53-MDM2 oscillation was observed only when p53 levels were in a specific range, and DNA damage was found to be necessary for triggering the p53-MDM2 oscillation.	tet	73-85	tumor protein p53	Homo sapiens	110-113
17363597-7	2007	Furthermore, using the H1299-HW24 cells expressing wild-type p53 under a tetracycline-regulated promoter, the p53-MDM2 oscillation was observed only when p53 levels were in a specific range, and DNA damage was found to be necessary for triggering the p53-MDM2 oscillation.	tet	73-85	MDM2 proto-oncogene	Homo sapiens	114-118
17363597-7	2007	Furthermore, using the H1299-HW24 cells expressing wild-type p53 under a tetracycline-regulated promoter, the p53-MDM2 oscillation was observed only when p53 levels were in a specific range, and DNA damage was found to be necessary for triggering the p53-MDM2 oscillation.	tet	73-85	tumor protein p53	Homo sapiens	110-113
17363597-7	2007	Furthermore, using the H1299-HW24 cells expressing wild-type p53 under a tetracycline-regulated promoter, the p53-MDM2 oscillation was observed only when p53 levels were in a specific range, and DNA damage was found to be necessary for triggering the p53-MDM2 oscillation.	tet	73-85	tumor protein p53	Homo sapiens	110-113
17363597-7	2007	Furthermore, using the H1299-HW24 cells expressing wild-type p53 under a tetracycline-regulated promoter, the p53-MDM2 oscillation was observed only when p53 levels were in a specific range, and DNA damage was found to be necessary for triggering the p53-MDM2 oscillation.	tet	73-85	MDM2 proto-oncogene	Homo sapiens	255-259
17223106-1	2007	An autoregulated tetracycline-inducible recombinant adeno-associated viral vector (rAAV-pTet(bidi)ON) utilizing the rtTAM2 reverse tetracycline transactivator (rAAV-rtTAM2) was used to conditionally express the human GDNF cDNA.	tet	17-29	glial cell derived neurotrophic factor	Homo sapiens	217-221
17223106-2	2007	Doxycycline, a tetracycline analog, induced a time- and dose-dependent release of GDNF in vitro in human glioma cells infected with rAAV-rtTAM2 serotype 2 virus.	tet	15-27	glial cell derived neurotrophic factor	Homo sapiens	82-86
17216583-7	2007	In the tetracycline (Tet)-On Jurkat T cells, ionomycin (Ion) only treatment didn"t induce apoptosis however it promoted inducible PADI4-decreased cell viability and -enhanced apoptosis.	tet	7-19	peptidyl arginine deiminase 4	Homo sapiens	130-135
17216583-7	2007	In the tetracycline (Tet)-On Jurkat T cells, ionomycin (Ion) only treatment didn"t induce apoptosis however it promoted inducible PADI4-decreased cell viability and -enhanced apoptosis.	tet	21-24	peptidyl arginine deiminase 4	Homo sapiens	130-135
17178837-8	2007	The tetracycline-controlled depletion of Sth1, the ATPase of RSC, or deletion of RSC2 severely reduces chromatin remodeling and loading of Mre11 and Yku proteins at the DSB.	tet	4-16	RSC chromatin remodeling complex ATPase subunit STH1	Saccharomyces cerevisiae S288C	41-45
17178837-8	2007	The tetracycline-controlled depletion of Sth1, the ATPase of RSC, or deletion of RSC2 severely reduces chromatin remodeling and loading of Mre11 and Yku proteins at the DSB.	tet	4-16	Rsc2p	Saccharomyces cerevisiae S288C	81-85
17178837-8	2007	The tetracycline-controlled depletion of Sth1, the ATPase of RSC, or deletion of RSC2 severely reduces chromatin remodeling and loading of Mre11 and Yku proteins at the DSB.	tet	4-16	MRX complex nuclease subunit	Saccharomyces cerevisiae S288C	139-144
17374729-6	2007	Likewise, ablation of the hPar1 gene in a tetracycline-inducible hPar1 system leads to apoptosis in immature blood vessels, whereas mature vessels were unaffected.	tet	42-54	coagulation factor II thrombin receptor	Homo sapiens	65-70
17126818-4	2007	We have generated stably transfected lines of the tetracycline-repressible MCF-7 cell line (MCF-7 Tet-Off) with inducible human PBR cDNA.	tet	50-62	translocator protein	Homo sapiens	128-131
17196286-4	2007	Capitalizing on bacterial transcriptional regulators (TetR, PIP, E), which are dose-dependently released from their cognate operators (tetO, PIR, ETR) upon binding of specific classes of antibiotics (tetracycline, streptogramins, macrolides) we have designed an easy-to-handle dipstick-based assay for detection of antibiotic levels in serum, meat and milk whose detection limits are up to 40-fold below licensed threshold values.	tet	200-212	prolactin induced protein	Homo sapiens	60-63
17196286-4	2007	Capitalizing on bacterial transcriptional regulators (TetR, PIP, E), which are dose-dependently released from their cognate operators (tetO, PIR, ETR) upon binding of specific classes of antibiotics (tetracycline, streptogramins, macrolides) we have designed an easy-to-handle dipstick-based assay for detection of antibiotic levels in serum, meat and milk whose detection limits are up to 40-fold below licensed threshold values.	tet	200-212	pirin	Homo sapiens	141-144
17319750-3	2007	We utilized the in vivo inducible tetracycline-controlled transactivator (tTA) system to regulate Clock gene expression conditionally in a tissue-specific and temporally controlled manner.	tet	34-46	circadian locomotor output cycles kaput	Mus musculus	98-103
17184743-12	2007	The tetracycline derivative, minocycline, reduced the BBB injury in mouse by blocking the production of MMP-9.	tet	4-16	matrix metallopeptidase 9	Mus musculus	104-109
17261708-8	2007	Certain MMP inhibitors, specifically tetracycline derivatives, can modulate microglial activation and reduce injury volume in limited studies.	tet	37-49	matrix metallopeptidase 2	Homo sapiens	8-11
17152078-2	2007	We demonstrate here that tetracycline (TC) can strongly interact (KD" = 189 +/- 7 nM) with model peptides derived from the C-terminal globular domain of the prion protein, hPrP [173-195], and that interaction concerns residues within the C-terminal half of the helix 2, a short region previously indicated as endowed with ambivalent conformational behavior and implicated in PrP conversion to the beta-sheet-rich, infective scrapie variant.	tet	25-37	prion protein	Homo sapiens	172-176
17152078-2	2007	We demonstrate here that tetracycline (TC) can strongly interact (KD" = 189 +/- 7 nM) with model peptides derived from the C-terminal globular domain of the prion protein, hPrP [173-195], and that interaction concerns residues within the C-terminal half of the helix 2, a short region previously indicated as endowed with ambivalent conformational behavior and implicated in PrP conversion to the beta-sheet-rich, infective scrapie variant.	tet	25-37	prion protein	Homo sapiens	173-176
17152078-2	2007	We demonstrate here that tetracycline (TC) can strongly interact (KD" = 189 +/- 7 nM) with model peptides derived from the C-terminal globular domain of the prion protein, hPrP [173-195], and that interaction concerns residues within the C-terminal half of the helix 2, a short region previously indicated as endowed with ambivalent conformational behavior and implicated in PrP conversion to the beta-sheet-rich, infective scrapie variant.	tet	39-41	prion protein	Homo sapiens	172-176
17152078-2	2007	We demonstrate here that tetracycline (TC) can strongly interact (KD" = 189 +/- 7 nM) with model peptides derived from the C-terminal globular domain of the prion protein, hPrP [173-195], and that interaction concerns residues within the C-terminal half of the helix 2, a short region previously indicated as endowed with ambivalent conformational behavior and implicated in PrP conversion to the beta-sheet-rich, infective scrapie variant.	tet	39-41	prion protein	Homo sapiens	173-176
17283151-8	2007	In the stable H1299 cell line with tetracycline-inducible p53 expression, induced p53 enhanced growth inhibition and apoptosis by gefitinib through the up-regulation of Fas and restoration of caspase activation.	tet	35-47	tumor protein p53	Homo sapiens	58-61
17283151-8	2007	In the stable H1299 cell line with tetracycline-inducible p53 expression, induced p53 enhanced growth inhibition and apoptosis by gefitinib through the up-regulation of Fas and restoration of caspase activation.	tet	35-47	tumor protein p53	Homo sapiens	82-85
16954505-8	2007	Tetracycline-inducible expression of KLF4 in B-cell progenitors of transgenic mice blocks transformation by BCR-ABL and depletes leukemic pre-B cells in vivo.	tet	0-12	Kruppel-like factor 4 (gut)	Mus musculus	37-41
16954505-8	2007	Tetracycline-inducible expression of KLF4 in B-cell progenitors of transgenic mice blocks transformation by BCR-ABL and depletes leukemic pre-B cells in vivo.	tet	0-12	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	108-115
16860395-2	2007	We, here report that human astrocytes derived from on NTera-2 (NT2) cell line expressing a functional anti-apoptotic protein bcl-2 under the control of a tetracycline responsive promoter using the Tet-On and Tet-Off expression systems.	tet	154-166	BCL2 apoptosis regulator	Homo sapiens	125-130
17234777-3	2007	We have elucidated the role of constitutive EGFR signaling in malignant progression by stably transfecting colon cancer cells with a human transforming growth factor-alpha cDNA (a ligand for EGFR) under repressible control by tetracycline.	tet	226-238	epidermal growth factor receptor	Homo sapiens	44-48
17234777-3	2007	We have elucidated the role of constitutive EGFR signaling in malignant progression by stably transfecting colon cancer cells with a human transforming growth factor-alpha cDNA (a ligand for EGFR) under repressible control by tetracycline.	tet	226-238	tumor necrosis factor	Homo sapiens	139-171
17234777-3	2007	We have elucidated the role of constitutive EGFR signaling in malignant progression by stably transfecting colon cancer cells with a human transforming growth factor-alpha cDNA (a ligand for EGFR) under repressible control by tetracycline.	tet	226-238	epidermal growth factor receptor	Homo sapiens	191-195
17098918-8	2007	Of 113 tetracycline-resistant E. coli isolates, tet(B) was the predominant resistance determinant and was detected in 93% of isolates, while the remaining 7% isolates carried the tet(A) determinant.	tet	7-19	TetB	Escherichia coli	48-54
17114320-5	2007	Further studies with a mexF deletion mutant demonstrated that the multidrug resistance pump encoded by mexF is required for resistance to antibiotics, including chloramphenicol and tetracycline.	tet	181-193	multidrug efflux RND transporter permease subunit	Shewanella oneidensis MR-1	23-27
17114320-5	2007	Further studies with a mexF deletion mutant demonstrated that the multidrug resistance pump encoded by mexF is required for resistance to antibiotics, including chloramphenicol and tetracycline.	tet	181-193	multidrug efflux RND transporter permease subunit	Shewanella oneidensis MR-1	103-107
18217680-2	2007	Inhibition of NF-kappaB by expression of a dominant negative signal phosphorylation site mutant of inhibitor-kappaB, IkappaBalphaM, under a tetracycline inducible promoter, established the role of NF-kappaB as an essential molecular switch modulating multiple genes important in the malignant phenotype.	tet	140-152	nuclear factor kappa B subunit 1	Homo sapiens	14-23
17214554-4	2007	Upon tetracycline-induced expression, both HNF4alpha isoforms caused distinct changes in cell morphology and a massive loss of cell numbers that was correlated with reduced proliferation and induced apoptosis.	tet	5-17	hepatocyte nuclear factor 4, alpha	Rattus norvegicus	43-52
17210690-2	2007	To identify novel regulators of p53, we have used a phenotype-based selection in which a total cDNA library in a retroviral vector has been introduced into TR9-7ER cells, which arrest when p53 is expressed from a tetracycline-regulated promoter.	tet	213-225	tumor protein p53	Homo sapiens	189-192
17210690-8	2007	When MCM5 cDNA was reintroduced into fresh TR9-7ER cells, numerous colonies that grow in the absence of tetracycline were formed.	tet	104-116	minichromosome maintenance complex component 5	Homo sapiens	5-9
17203662-4	2007	Removal of this cassette by Cre-mediated recombination led to 5-HT(1B) receptor expression, which was highly regulatable when doxycycline, a derivative of tetracycline, was administered to the mice.	tet	155-167	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	62-79
18154515-3	2007	Mouse embryonic stem (ES) cells were transfected with an inducible, bidirectional tetracycline (Bi-Tet) promoter driving VEGF(165) and renilla luciferase (Rluc).	tet	82-94	vascular endothelial growth factor A	Mus musculus	121-125
17192486-4	2007	First, we investigated the effect of agents known to inhibit caspase-1 (minocycline and tetracycline) on IL-1beta production and retinal capillary degeneration in diabetic and galactose-fed mice.	tet	88-100	interleukin 1 beta	Mus musculus	105-113
17192486-9	2007	Tetracycline inhibited hyperglycemia-induced caspase-1 activity in vitro but not in vivo.	tet	0-12	caspase 1	Mus musculus	45-54
16912231-6	2006	Furthermore, in lethally irradiated mice reconstituted with bone marrow infected by a tetracycline-regulated, SOCS-expressing lentiviral vector, doxycycline treatment promoted rapid, extensive precursor mobilization to the periphery.	tet	86-98	cytokine inducible SH2-containing protein	Mus musculus	110-114
17237271-3	2007	In HepG2 AD38 cells, which express HBV genome under the control of a tetracycline-off promoter, both Akt and STAT3 were constitutively activated in response to HBV expression.	tet	69-81	AKT serine/threonine kinase 1	Homo sapiens	101-104
17237271-3	2007	In HepG2 AD38 cells, which express HBV genome under the control of a tetracycline-off promoter, both Akt and STAT3 were constitutively activated in response to HBV expression.	tet	69-81	signal transducer and activator of transcription 3	Homo sapiens	109-114
17237271-5	2007	Interestingly, the electrophoretic mobility of p-STAT3 protein bands on immunoblot was slower when AD38 cells were cultured in the absence of tetracycline, suggesting a differential phosphorylation in response to HBV expression.	tet	142-154	signal transducer and activator of transcription 3	Homo sapiens	49-54
16929489-6	2006	In the current study, a gene inactivation test (GIT) utilizing a tetracycline regulation system was used to study the functional role of BLU/ZMYND10.	tet	65-77	zinc finger, MYND domain containing 10	Mus musculus	137-140
17545198-3	2007	The transcription factor TetR, a regulator of tetracycline resistance in Gram-negative bacteria, is naturally induced by tetracycline or its derivatives.	tet	46-58	tetracycline resistance repressor protein TetR	Escherichia coli	25-29
17545198-3	2007	The transcription factor TetR, a regulator of tetracycline resistance in Gram-negative bacteria, is naturally induced by tetracycline or its derivatives.	tet	121-133	tetracycline resistance repressor protein TetR	Escherichia coli	25-29
17166390-8	2006	Then, Tetracycline was added to the culture medium immediately after co-transfection in gradient concentration and 48 h after co-transfection to observe its effect on IFNgamma secretion.	tet	6-18	interferon gamma	Homo sapiens	167-175
17166390-12	2006	Increasing tetracycline decreased the secretion of IFNgamma in the first 48 h: 10-100 ng/ml tetracycline decreased the secretion to nearly 0.	tet	11-23	interferon gamma	Homo sapiens	51-59
17166390-12	2006	Increasing tetracycline decreased the secretion of IFNgamma in the first 48 h: 10-100 ng/ml tetracycline decreased the secretion to nearly 0.	tet	92-104	interferon gamma	Homo sapiens	51-59
17253956-4	2006	To generate tools to study the relationships of transcription factors in pancreatic development we have established seven unique mouse ES cell lines with tetracycline-inducible expression of either Hnf4alpha, Hnf6, Nkx2.2, Nkx6.1, Pax4, Pdx1, and Ptf1a cDNAs.	tet	154-166	paired box 4	Mus musculus	231-235
16841082-0	2006	Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer.	tet	0-12	interleukin 3	Mus musculus	50-63
16841082-3	2006	Because high systemic levels of IL-3 can be associated with toxicity, a tetracycline-regulated gene delivery system was employed.	tet	72-84	interleukin 3	Mus musculus	32-36
16841082-6	2006	The study demonstrates that tetracycline-regulated IL-3 gene expression within tumors can enhance the immune response to prostate cancer and this can augment the efficacy of a course of RT without additional side effects.	tet	28-40	interleukin 3	Mus musculus	51-55
17253956-4	2006	To generate tools to study the relationships of transcription factors in pancreatic development we have established seven unique mouse ES cell lines with tetracycline-inducible expression of either Hnf4alpha, Hnf6, Nkx2.2, Nkx6.1, Pax4, Pdx1, and Ptf1a cDNAs.	tet	154-166	hepatic nuclear factor 4, alpha	Mus musculus	198-207
17253956-4	2006	To generate tools to study the relationships of transcription factors in pancreatic development we have established seven unique mouse ES cell lines with tetracycline-inducible expression of either Hnf4alpha, Hnf6, Nkx2.2, Nkx6.1, Pax4, Pdx1, and Ptf1a cDNAs.	tet	154-166	one cut domain, family member 1	Mus musculus	209-213
17253956-4	2006	To generate tools to study the relationships of transcription factors in pancreatic development we have established seven unique mouse ES cell lines with tetracycline-inducible expression of either Hnf4alpha, Hnf6, Nkx2.2, Nkx6.1, Pax4, Pdx1, and Ptf1a cDNAs.	tet	154-166	NK2 homeobox 2	Mus musculus	215-221
17253956-4	2006	To generate tools to study the relationships of transcription factors in pancreatic development we have established seven unique mouse ES cell lines with tetracycline-inducible expression of either Hnf4alpha, Hnf6, Nkx2.2, Nkx6.1, Pax4, Pdx1, and Ptf1a cDNAs.	tet	154-166	NK6 homeobox 1	Mus musculus	223-229
17285112-4	2006	RESULTS: T-rex HEK-HBD2-m cell subline was shown to express both mRNA and hBD-2m protein upon the presence of 1 mug/ml tetracycline in culture medium as it was demonstrated by RT-PCR and immunocytochemical approach.	tet	119-131	defensin beta 4A	Homo sapiens	19-23
17285112-4	2006	RESULTS: T-rex HEK-HBD2-m cell subline was shown to express both mRNA and hBD-2m protein upon the presence of 1 mug/ml tetracycline in culture medium as it was demonstrated by RT-PCR and immunocytochemical approach.	tet	119-131	defensin beta 4A	Homo sapiens	74-79
17002559-7	2006	MATERIALS AND METHODS: We used in vivo implanted C3H10T1/2 cells that had been genetically engineered to express human bone morphogenetic protein-2 (BMP2) in a tetracycline-regulated system that controls osteogenic differentiation.	tet	160-172	bone morphogenetic protein 2	Homo sapiens	119-147
17002559-7	2006	MATERIALS AND METHODS: We used in vivo implanted C3H10T1/2 cells that had been genetically engineered to express human bone morphogenetic protein-2 (BMP2) in a tetracycline-regulated system that controls osteogenic differentiation.	tet	160-172	bone morphogenetic protein 2	Homo sapiens	149-153
17217617-6	2006	Tetracycline-induced wild-type (wt) Prox1 in tumor cells inhibited transforming activity and cellular proliferation.	tet	0-12	prospero homeobox 1	Homo sapiens	36-41
17217617-8	2006	In mice, xenografts of tumor cells with tetracycline-induced wt-Prox1 formed tumor masses significantly more slowly than control tumors, whereas mutated Prox1 had no effect.	tet	40-52	prospero homeobox 1	Mus musculus	64-69
17055069-6	2006	Several tetracycline antibiotics are also potent PARP-1 inhibitors.	tet	8-20	poly(ADP-ribose) polymerase 1	Homo sapiens	49-55
17253956-4	2006	To generate tools to study the relationships of transcription factors in pancreatic development we have established seven unique mouse ES cell lines with tetracycline-inducible expression of either Hnf4alpha, Hnf6, Nkx2.2, Nkx6.1, Pax4, Pdx1, and Ptf1a cDNAs.	tet	154-166	pancreatic and duodenal homeobox 1	Mus musculus	237-241
16987810-5	2006	To examine the phenotype associated with expression of these mutants, we generated tetracycline-inducible human osteosarcoma cells lines expressing R155E,R157E mutants of CKIP-1.	tet	83-95	pleckstrin homology domain containing O1	Homo sapiens	171-177
16927018-8	2006	However, introduced cyclin D1 into Jurkat T tetracycline (Tet)-On cell system still couldn"t rescue cells from apoptosis.	tet	58-61	cyclin D1	Homo sapiens	20-29
16780964-5	2006	We predicted that the secretion of HBV e antigen (HBeAg) by HepAD38 cells, a tetracycline inducible HBV expression cell line, would be cccDNA-dependent.	tet	77-89	capsid protein;pre-capsid protein	Hepatitis B virus	50-55
16882883-1	2006	To investigate molecular mechanisms involved in the development of cardiac hypertrophy and heart failure, we developed a tetracycline-regulated transgenic system to conditionally switch a constitutively active form of the Akt1 protein kinase on or off in the adult heart.	tet	121-133	thymoma viral proto-oncogene 1	Mus musculus	222-226
16652145-1	2006	Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis.	tet	18-30	CD44 molecule (Indian blood group)	Homo sapiens	112-116
16652145-1	2006	Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis.	tet	18-30	CD44 molecule (Indian blood group)	Homo sapiens	132-136
16652145-1	2006	Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis.	tet	18-30	CD44 molecule (Indian blood group)	Homo sapiens	132-136
16652145-1	2006	Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis.	tet	18-30	cortactin	Homo sapiens	264-268
16652145-1	2006	Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis.	tet	18-30	cortactin	Homo sapiens	269-278
16652145-1	2006	Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis.	tet	18-21	CD44 molecule (Indian blood group)	Homo sapiens	112-116
16652145-1	2006	Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis.	tet	18-21	CD44 molecule (Indian blood group)	Homo sapiens	132-136
16652145-1	2006	Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis.	tet	18-21	CD44 molecule (Indian blood group)	Homo sapiens	132-136
16935386-5	2006	METHODS: Based on the tetracycline (Tet)-regulated TetOFF system, a Tet-responsive promoter-controlled HBV genome was introduced into separately established, well-regulatable HepG2 and Huh7 lines expressing Tet-responsive trans-activators (tTAs).	tet	22-34	MIR7-3 host gene	Homo sapiens	185-189
16935386-5	2006	METHODS: Based on the tetracycline (Tet)-regulated TetOFF system, a Tet-responsive promoter-controlled HBV genome was introduced into separately established, well-regulatable HepG2 and Huh7 lines expressing Tet-responsive trans-activators (tTAs).	tet	36-39	MIR7-3 host gene	Homo sapiens	185-189
16935386-7	2006	RESULTS: HepG2- and Huh7-based cell lines were established which, Tet-controllably, produce more HBV than HepG2.2.15 cells.	tet	66-69	MIR7-3 host gene	Homo sapiens	20-24
16702944-4	2006	In this cell line, PLSCR1 was tightly regulated and induced upon tetracycline withdrawal.	tet	65-77	phospholipid scramblase 1	Homo sapiens	19-25
16652145-2	2006	In functional experiments, tet-regulated induction of CD44s potentiated the migration and invasion of MCF7F cells through HA-supplemented Matrigel.	tet	27-30	CD44 molecule (Indian blood group)	Homo sapiens	54-58
16861620-1	2006	The reversibility and regression of histological and biochemical findings in a mouse model of Gaucher disease (4L/PS-NA) was evaluated using a liver-enriched activator protein promoter control of a tetracycline-controlled transcriptional activation-responsive human acid beta-glucosidase (hGCase) transgenic system.	tet	198-210	glucosylceramidase beta	Homo sapiens	266-287
16904653-4	2006	METHODS: Conditional transgenic (Tet/AS) mice were created with tetracycline-induced antisense suppression of AChE gene expression.	tet	64-76	acetylcholinesterase	Mus musculus	110-114
17018592-4	2006	A tetracycline-inducible expression vector, pETE-Bsd, was also used to obtain stable transfectants of TSLC1.	tet	2-14	cell adhesion molecule 1	Homo sapiens	102-107
16966095-2	2006	Using a model cell line in which p53 expression is regulated exogenously in a tetracycline-off system (TR9-7 cells) , our laboratory has shown that arsenite disrupts mitosis and that p53-deficient cells [p53(-)], in contrast to p53-expressing cells [p53(+)], display greater sensitivity to arsenite-induced mitotic arrest and apoptosis.	tet	78-90	tumor protein p53	Homo sapiens	33-36
17131815-2	2006	Earlier we have demonstrated that sarcomeric cytoskeletal proteins of the titin family (X-, C-, and H-proteins) are capable to form in vitro amyloid fibrils, and tetracycline effectively destroys these fibrils.	tet	162-174	titin	Homo sapiens	74-79
17062347-0	2006	[Construction and identification of tetracycline-inducible human hepatocyte growth factor eukaryotic expression vector].	tet	36-48	hepatocyte growth factor	Homo sapiens	65-89
17062347-1	2006	OBJECTIVE: To construct a tetracycline-inducible eukaryotic expression vector containing human hepatocyte growth factor (HGF) cDNA.	tet	26-38	hepatocyte growth factor	Homo sapiens	95-119
17062347-1	2006	OBJECTIVE: To construct a tetracycline-inducible eukaryotic expression vector containing human hepatocyte growth factor (HGF) cDNA.	tet	26-38	hepatocyte growth factor	Homo sapiens	121-124
17062347-2	2006	METHODS: Human HGF cDNA fragment was obtained by PCR from pUC-SRalpha/HGF plasmid and inserted into the restriction site between Mlu I and Sal I of the tetracycline-inducible eukaryotic expression vector pBI-L. pBI-L-HGF was constructed by DNA recombination in vitro, and was identified by restriction endonucleases digestion and sequencing.	tet	152-164	hepatocyte growth factor	Homo sapiens	15-18
17062347-2	2006	METHODS: Human HGF cDNA fragment was obtained by PCR from pUC-SRalpha/HGF plasmid and inserted into the restriction site between Mlu I and Sal I of the tetracycline-inducible eukaryotic expression vector pBI-L. pBI-L-HGF was constructed by DNA recombination in vitro, and was identified by restriction endonucleases digestion and sequencing.	tet	152-164	hepatocyte growth factor	Homo sapiens	70-73
17062347-2	2006	METHODS: Human HGF cDNA fragment was obtained by PCR from pUC-SRalpha/HGF plasmid and inserted into the restriction site between Mlu I and Sal I of the tetracycline-inducible eukaryotic expression vector pBI-L. pBI-L-HGF was constructed by DNA recombination in vitro, and was identified by restriction endonucleases digestion and sequencing.	tet	152-164	hepatocyte growth factor	Homo sapiens	70-73
17062347-4	2006	CONCLUSION: The tetracycline-inducible eukaryotic expression vector of human HGF pBI-L-HGF has been constructed successfully, which allows further study of HGF gene therapy with much safety and easy manipulation.	tet	16-28	hepatocyte growth factor	Homo sapiens	77-80
17062347-4	2006	CONCLUSION: The tetracycline-inducible eukaryotic expression vector of human HGF pBI-L-HGF has been constructed successfully, which allows further study of HGF gene therapy with much safety and easy manipulation.	tet	16-28	hepatocyte growth factor	Homo sapiens	87-90
17062347-4	2006	CONCLUSION: The tetracycline-inducible eukaryotic expression vector of human HGF pBI-L-HGF has been constructed successfully, which allows further study of HGF gene therapy with much safety and easy manipulation.	tet	16-28	hepatocyte growth factor	Homo sapiens	87-90
16619034-3	2006	In our current report, we used DLD-1 colorectal cancer cells stably transfected with the POX gene under the control of a tetracycline-inducible promoter and found POX-stimulated expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL), DR5 and cleavage of caspase-8.	tet	121-133	proline dehydrogenase 1	Homo sapiens	89-92
16619034-3	2006	In our current report, we used DLD-1 colorectal cancer cells stably transfected with the POX gene under the control of a tetracycline-inducible promoter and found POX-stimulated expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL), DR5 and cleavage of caspase-8.	tet	121-133	proline dehydrogenase 1	Homo sapiens	163-166
16619034-3	2006	In our current report, we used DLD-1 colorectal cancer cells stably transfected with the POX gene under the control of a tetracycline-inducible promoter and found POX-stimulated expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL), DR5 and cleavage of caspase-8.	tet	121-133	TNF superfamily member 10	Homo sapiens	192-247
16870143-3	2006	Here, we present the first application of the Tc-inducible, stably integrated plasmid-based siRNA system in mouse ES cells to down-regulate expression of Npm1, an essential gene for embryonic development.	tet	46-48	nucleophosmin 1	Mus musculus	154-158
16870143-5	2006	Our data show that the knock-down of Npm1 expression by this siRNA system was not only highly efficient, but also Tc- dose- and induction time-dependent.	tet	114-116	nucleophosmin 1	Mus musculus	37-41
16675709-0	2006	Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells.	tet	0-12	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	146-151
16652376-3	2006	Here, we establish stable clones of the human breast cancer cell line MDA-MB-361DYT2 that express PEA3 under the control of a tetracycline-inducible promoter.	tet	126-138	ETS variant transcription factor 4	Homo sapiens	98-102
16982444-0	2006	[Construction and identification of tetracycline-inducible rat Smad7 eukaryotic expression vector].	tet	36-48	SMAD family member 7	Rattus norvegicus	63-68
16982444-1	2006	OBJECTIVE: To construct a tetracycline-inducible eukaryotic expression vector of rat Smad7.	tet	26-38	SMAD family member 7	Rattus norvegicus	85-90
16982444-3	2006	Rat Smad7 cDNA fragment was cloned by RT-PCR, and was inserted into the restriction site between Nhe I and Hind III of the inducible eukaryotic expression vector pBI-L by tetracycline.	tet	171-183	SMAD family member 7	Rattus norvegicus	4-9
16982444-7	2006	CONCLUSION: The tetracycline- inducible eukaryotic expression vector of rat Smad7, pBI-L-Smad7, is constructed successfully, which may facilitate further clinical study of Smad7 gene therapy for tissue and organ fibrosis.	tet	16-28	SMAD family member 7	Rattus norvegicus	76-81
16982444-7	2006	CONCLUSION: The tetracycline- inducible eukaryotic expression vector of rat Smad7, pBI-L-Smad7, is constructed successfully, which may facilitate further clinical study of Smad7 gene therapy for tissue and organ fibrosis.	tet	16-28	SMAD family member 7	Rattus norvegicus	89-94
16982444-7	2006	CONCLUSION: The tetracycline- inducible eukaryotic expression vector of rat Smad7, pBI-L-Smad7, is constructed successfully, which may facilitate further clinical study of Smad7 gene therapy for tissue and organ fibrosis.	tet	16-28	SMAD family member 7	Rattus norvegicus	89-94
16242193-3	2006	METHODS: The effects of tetracycline derivatives (tetracycline and CMTs-3, -5, -8) on MMP-2 and -9 and their endogenous tissue inhibitor (TIMP-1 and -2) production profiles in explanted human aortic valve pieces were examined by means of gelatine zymography and reverse zymography.	tet	24-36	matrix metallopeptidase 2	Homo sapiens	86-98
16242193-3	2006	METHODS: The effects of tetracycline derivatives (tetracycline and CMTs-3, -5, -8) on MMP-2 and -9 and their endogenous tissue inhibitor (TIMP-1 and -2) production profiles in explanted human aortic valve pieces were examined by means of gelatine zymography and reverse zymography.	tet	50-62	matrix metallopeptidase 2	Homo sapiens	86-98
16242193-7	2006	Tetracycline was the only drug with a significant impact on net gelatinolytic activity, suggesting that the effect of tetracycline is more extensive concerning total MMP activity.	tet	0-12	matrix metallopeptidase 2	Homo sapiens	166-169
16242193-7	2006	Tetracycline was the only drug with a significant impact on net gelatinolytic activity, suggesting that the effect of tetracycline is more extensive concerning total MMP activity.	tet	118-130	matrix metallopeptidase 2	Homo sapiens	166-169
16242193-8	2006	CONCLUSIONS: Tetracycline derivatives may have therapeutic effects on the pathologic remodellation of advanced human aortic stenosis through the inhibition of MMP-9 and VEGF production.	tet	13-25	matrix metallopeptidase 9	Homo sapiens	159-164
16242193-8	2006	CONCLUSIONS: Tetracycline derivatives may have therapeutic effects on the pathologic remodellation of advanced human aortic stenosis through the inhibition of MMP-9 and VEGF production.	tet	13-25	vascular endothelial growth factor A	Homo sapiens	169-173
16877361-5	2006	Using MCF-7 cells transfected with tetracycline-off STAT3C (constitutively active STAT3), we generated an in vitro system in which STAT3C levels can be tightly controlled in breast cancer cells.	tet	35-47	signal transducer and activator of transcription 3	Homo sapiens	52-57
16877361-6	2006	Increasing tetracycline levels gradually decreased STAT3C and TIMP1 in a dose-dependent manner, and down-regulation of these proteins led to a reciprocal decrease in invasiveness of these cells in Matrigel.	tet	11-23	TIMP metallopeptidase inhibitor 1	Homo sapiens	62-67
16873682-4	2006	To address this, we generated a tetracycline-inducible mouse model that transcribes HNF1alpha selectively in beta-cells in either wild-type or Hnf1alpha-null backgrounds.	tet	32-44	HNF1 homeobox A	Mus musculus	84-93
16842566-7	2006	Most isolates showed resistance to tetracycline and fusidic acid because of the presence of the tetK and far1 genes.	tet	35-47	Far1	Staphylococcus aureus	105-109
16873682-4	2006	To address this, we generated a tetracycline-inducible mouse model that transcribes HNF1alpha selectively in beta-cells in either wild-type or Hnf1alpha-null backgrounds.	tet	32-44	HNF1 homeobox A	Mus musculus	143-152
16849574-3	2006	In the present study, we used a tetracycline E2F-1 inducible U2OS osteosarcoma cell line to investigate the effect of increasing levels of E2F-1 on the cytotoxicity of various chemotherapeutic drugs.	tet	32-44	E2F transcription factor 1	Homo sapiens	45-50
16728403-1	2006	To study the role of c-Src in breast cancer tumorigenesis, we generated a cell line derived from MCF7 carrying an inducible dominant negative c-Src (c-SrcDN: K295M/Y527F) under tetracycline control (Tet-On system).	tet	177-189	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	142-147
16849588-6	2006	In MCF-7 cells expressing tetracycline-inducible prohibitin (Tet-On model), the overexpression of prohibitin inhibited cell proliferation and enhanced vitamin D-induced antiproliferative activity.	tet	26-38	prohibitin 1	Homo sapiens	49-59
16849588-6	2006	In MCF-7 cells expressing tetracycline-inducible prohibitin (Tet-On model), the overexpression of prohibitin inhibited cell proliferation and enhanced vitamin D-induced antiproliferative activity.	tet	26-38	prohibitin 1	Homo sapiens	98-108
16199137-5	2006	We have generated tetracycline-inducible stable cell lines that express a wild type or kinase-inactive mutant form of IKK-i.	tet	18-30	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	118-123
16810323-7	2006	In a tetracycline-inducible system, increased S6K2 kinase activity triggers upregulation of XIAP, Bcl-X(L) and prosurvival effects.	tet	5-17	ribosomal protein S6 kinase B2	Homo sapiens	46-50
16810323-7	2006	In a tetracycline-inducible system, increased S6K2 kinase activity triggers upregulation of XIAP, Bcl-X(L) and prosurvival effects.	tet	5-17	X-linked inhibitor of apoptosis	Homo sapiens	92-96
16810323-7	2006	In a tetracycline-inducible system, increased S6K2 kinase activity triggers upregulation of XIAP, Bcl-X(L) and prosurvival effects.	tet	5-17	BCL2 like 1	Homo sapiens	98-106
16624812-3	2006	To further understand how excess HDM2 regulates p53-mediated functions, we generated H1299 cell clones that constitutively express both ectopic HDM2 and tetracycline-regulated inducible p53.	tet	153-165	MDM2 proto-oncogene	Homo sapiens	33-37
16482519-2	2006	We previously reported the development of a bitransgenic mouse model that expressed the human Ki-ras(G12C) allele in a lung-specific, tetracycline-inducible manner and gave rise to benign lung tumors.	tet	134-146	KRAS proto-oncogene, GTPase	Homo sapiens	94-100
16819299-4	2006	Induction of CAGE by tetracycline or transient transfection enhanced the migration and invasiveness of HeLa cells, but not the adhesiveness of either cell line.	tet	21-33	DEAD-box helicase 53	Homo sapiens	13-17
16786135-5	2006	We have used tetracycline controlled expression of p16 and plasmid-based p14ARF expression to study the chemo- and radiosensitivity of glioma cell lines.	tet	13-25	cyclin dependent kinase inhibitor 2A	Homo sapiens	51-54
16624812-3	2006	To further understand how excess HDM2 regulates p53-mediated functions, we generated H1299 cell clones that constitutively express both ectopic HDM2 and tetracycline-regulated inducible p53.	tet	153-165	tumor protein p53	Homo sapiens	48-51
16624812-3	2006	To further understand how excess HDM2 regulates p53-mediated functions, we generated H1299 cell clones that constitutively express both ectopic HDM2 and tetracycline-regulated inducible p53.	tet	153-165	tumor protein p53	Homo sapiens	186-189
16740695-1	2006	SSeCKS, a Src-suppressed protein kinase C substrate with metastasis suppressor activity, is the rodent orthologue of human gravin/AKAP12, a scaffolding protein for protein kinase A and protein kinase C. We show here that the tetracycline-regulated reexpression of SSeCKS in MatLyLu (MLL) prostate cancer cells suppressed formation of macroscopic lung metastases in both spontaneous and experimental models of in vivo metastasis while having minimal inhibitory effects on the growth of primary-site s.c. tumors.	tet	225-237	A-kinase anchoring protein 12	Homo sapiens	0-6
16584838-4	2006	To test the assumption that the combination of the two strategies may have a compound or synergistic effect, we had constructed tetracycline-inducible (tet-off) AAV vector carrying GDNF and TH.	tet	128-140	glial cell derived neurotrophic factor	Rattus norvegicus	181-185
16769901-2	2006	Here we report that PARP-1 enzymatic activity is directly inhibited by minocycline and other tetracycline derivatives that have previously been shown to have neuroprotective and anti-inflammatory actions.	tet	93-105	poly(ADP-ribose) polymerase 1	Homo sapiens	20-26
16769901-7	2006	Comparison of several tetracycline derivatives showed a strong correlation (r(2) = 0.87) between potency as a PARP-1 inhibitor and potency as a neuroprotective agent during MNNG incubations, with the rank order of potency being minocycline &gt; doxycycline &gt; demeclocycline &gt; chlortetracycline.	tet	22-34	poly(ADP-ribose) polymerase 1	Homo sapiens	110-116
16769901-9	2006	The neuroprotective and antiinflammatory effects of minocycline and other tetracycline derivatives may be attributable to PARP-1 inhibition in some settings.	tet	74-86	poly(ADP-ribose) polymerase 1	Homo sapiens	122-128
16631626-5	2006	METHODS: A tetracycline-regulated transgene was used to express JDP2 specifically in the mouse heart.	tet	11-23	Jun dimerization protein 2	Mus musculus	64-68
16740695-1	2006	SSeCKS, a Src-suppressed protein kinase C substrate with metastasis suppressor activity, is the rodent orthologue of human gravin/AKAP12, a scaffolding protein for protein kinase A and protein kinase C. We show here that the tetracycline-regulated reexpression of SSeCKS in MatLyLu (MLL) prostate cancer cells suppressed formation of macroscopic lung metastases in both spontaneous and experimental models of in vivo metastasis while having minimal inhibitory effects on the growth of primary-site s.c. tumors.	tet	225-237	A-kinase anchoring protein 12	Homo sapiens	130-136
16740695-1	2006	SSeCKS, a Src-suppressed protein kinase C substrate with metastasis suppressor activity, is the rodent orthologue of human gravin/AKAP12, a scaffolding protein for protein kinase A and protein kinase C. We show here that the tetracycline-regulated reexpression of SSeCKS in MatLyLu (MLL) prostate cancer cells suppressed formation of macroscopic lung metastases in both spontaneous and experimental models of in vivo metastasis while having minimal inhibitory effects on the growth of primary-site s.c. tumors.	tet	225-237	A-kinase anchoring protein 12	Homo sapiens	264-270
16462771-5	2006	Tetracycline-induced expression of DEC1 in stable lines proportionally increased the expression of survivin.	tet	0-12	deleted in esophageal cancer 1	Homo sapiens	35-39
16469769-2	2006	To investigate the role of p190-B during distinct stages of mammary gland development, tetracycline-regulatable p190-B-overexpressing mice were generated.	tet	87-99	Rho GTPase activating protein 5	Mus musculus	112-118
16496016-4	2006	To address these limitations, this work describes a retroviral system to deliver the Runx2 osteoblastic transcription factor under control of the tetracycline-inducible (tet-off) promoter in primary skeletal myoblasts.	tet	146-158	runt related transcription factor 2	Mus musculus	85-90
16482431-0	2006	Inactivation of the putative tetracycline resistance gene HP1165 in Helicobacter pylori led to loss of inducible tetracycline resistance.	tet	29-41	MFS transporter	Helicobacter pylori 26695	58-64
16731977-0	2006	The synthesis and high-level expression of a beta2-adrenergic receptor gene in a tetracycline-inducible stable mammalian cell line.	tet	81-93	adrenoceptor beta 2	Homo sapiens	45-70
16731977-5	2006	Previously, we reported the development of an HEK293S tetracycline-inducible system for high-level expression of rhodopsin.	tet	54-66	rhodopsin	Homo sapiens	113-122
16482431-10	2006	Mutation of HP1165 gene resulted in increased tetracycline susceptibility and loss of inducible tetracycline resistance, suggesting that the HP1165 gene is involved in the inducible tetracycline resistance in H. pylori.	tet	46-58	MFS transporter	Helicobacter pylori 26695	141-147
16482431-0	2006	Inactivation of the putative tetracycline resistance gene HP1165 in Helicobacter pylori led to loss of inducible tetracycline resistance.	tet	113-125	MFS transporter	Helicobacter pylori 26695	58-64
16482431-10	2006	Mutation of HP1165 gene resulted in increased tetracycline susceptibility and loss of inducible tetracycline resistance, suggesting that the HP1165 gene is involved in the inducible tetracycline resistance in H. pylori.	tet	96-108	MFS transporter	Helicobacter pylori 26695	12-18
16482431-10	2006	Mutation of HP1165 gene resulted in increased tetracycline susceptibility and loss of inducible tetracycline resistance, suggesting that the HP1165 gene is involved in the inducible tetracycline resistance in H. pylori.	tet	96-108	MFS transporter	Helicobacter pylori 26695	141-147
16482431-5	2006	HP1165, a putative tetracycline resistance gene in H. pylori 26695, displays 49.8% identity to the tetracycline efflux gene tetA (P) from Clostridium perfringens.	tet	19-31	MFS transporter	Helicobacter pylori 26695	0-6
16482431-10	2006	Mutation of HP1165 gene resulted in increased tetracycline susceptibility and loss of inducible tetracycline resistance, suggesting that the HP1165 gene is involved in the inducible tetracycline resistance in H. pylori.	tet	96-108	MFS transporter	Helicobacter pylori 26695	12-18
16482431-5	2006	HP1165, a putative tetracycline resistance gene in H. pylori 26695, displays 49.8% identity to the tetracycline efflux gene tetA (P) from Clostridium perfringens.	tet	99-111	MFS transporter	Helicobacter pylori 26695	0-6
16482431-10	2006	Mutation of HP1165 gene resulted in increased tetracycline susceptibility and loss of inducible tetracycline resistance, suggesting that the HP1165 gene is involved in the inducible tetracycline resistance in H. pylori.	tet	96-108	MFS transporter	Helicobacter pylori 26695	141-147
16482431-10	2006	Mutation of HP1165 gene resulted in increased tetracycline susceptibility and loss of inducible tetracycline resistance, suggesting that the HP1165 gene is involved in the inducible tetracycline resistance in H. pylori.	tet	46-58	MFS transporter	Helicobacter pylori 26695	12-18
16651432-7	2006	Furthermore, we find that apoptosis induced by expression of wild-type PTEN, driven by a tetracycline-inducible expression system in LNCaP cells, can be inhibited by blocking Fas/FasL interaction using Fas:Fc or Nok-1.	tet	89-101	phosphatase and tensin homolog	Homo sapiens	71-75
16651432-7	2006	Furthermore, we find that apoptosis induced by expression of wild-type PTEN, driven by a tetracycline-inducible expression system in LNCaP cells, can be inhibited by blocking Fas/FasL interaction using Fas:Fc or Nok-1.	tet	89-101	Fas ligand	Homo sapiens	179-183
16681577-7	2006	Considering that tetracycline antibiotics, but not macrolide antibiotics, inhibit the activity of pancreatic lipase in vitro, the efficiency of tetracycline antibiotics may be a clue to clarifying the pathogenesis of this disorder.	tet	17-29	pancreatic lipase	Homo sapiens	98-115
16585511-6	2006	Normal growth was, however, restored upon expression of mVDAC1 in a tetracycline-regulated manner.	tet	68-80	voltage-dependent anion channel 1	Mus musculus	56-62
16365885-6	2006	We applied these modified p27 genes as novel anticancer agents for HER2-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	116-128	interferon alpha inducible protein 27	Homo sapiens	26-29
16365885-6	2006	We applied these modified p27 genes as novel anticancer agents for HER2-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	116-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-71
16365885-6	2006	We applied these modified p27 genes as novel anticancer agents for HER2-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	116-119	interferon alpha inducible protein 27	Homo sapiens	26-29
16365885-6	2006	We applied these modified p27 genes as novel anticancer agents for HER2-overexpressing cells under the control of a tetracycline (tet)-regulated gene expression system.	tet	116-119	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-71
17241592-4	2006	OBJECTIVE: We report a case of an HIV-seropositive man on HAART (CD4 count 450 cells/microL) who developed isolated hypertriglyceridemia (&gt; 13 mmol/L) after three separate challenges with minocycline or tetracycline, improving each time therapy was discontinued.	tet	206-218	CD4 molecule	Homo sapiens	65-68
16524894-7	2006	Antimicrobial susceptibility profiling of E. coli K12 transformed with CG 2 large plasmids confirmed that the bla(CMY-7)-carrying plasmid did not carry any other antimicrobial resistance genes, whereas the bla(TEM)/class 1 integron-carrying plasmid carried genes conferring resistance to tetracycline and streptomycin also.	tet	288-300	beta-lactamase	Escherichia coli	110-113
16643778-0	2006	[Construction of Tet-on inducible CXCR1 eukaryotic expression plasmid and identification of the expression character in NIH3T3 cells].	tet	17-20	chemokine (C-X-C motif) receptor 1	Mus musculus	34-39
16643778-1	2006	AIM: To construct tetracycline (Tet)-controlled inducible vector CXCR1-pTREhyg, and then detect the expression character of CXCR1 under the regulation of Dox in NIH3T3 cells.	tet	18-30	chemokine (C-X-C motif) receptor 1	Mus musculus	65-70
16643778-1	2006	AIM: To construct tetracycline (Tet)-controlled inducible vector CXCR1-pTREhyg, and then detect the expression character of CXCR1 under the regulation of Dox in NIH3T3 cells.	tet	18-30	chemokine (C-X-C motif) receptor 1	Mus musculus	124-129
16643778-1	2006	AIM: To construct tetracycline (Tet)-controlled inducible vector CXCR1-pTREhyg, and then detect the expression character of CXCR1 under the regulation of Dox in NIH3T3 cells.	tet	32-35	chemokine (C-X-C motif) receptor 1	Mus musculus	65-70
16643778-1	2006	AIM: To construct tetracycline (Tet)-controlled inducible vector CXCR1-pTREhyg, and then detect the expression character of CXCR1 under the regulation of Dox in NIH3T3 cells.	tet	32-35	chemokine (C-X-C motif) receptor 1	Mus musculus	124-129
16643778-5	2006	CONCLUSION: Tet inducible recombinant vector of CXCR1-pTREhyg was successfully constructed, and it could be expressed in NIH3T3 cells.	tet	12-15	chemokine (C-X-C motif) receptor 1	Mus musculus	48-53
16638134-2	2006	We previously used NIH3T3 cells with tetracycline-regulated SSeCKS expression plus a temperature-sensitive v-Src allele to show that SSeCKS re-expression inhibited parameters of v-Src-induced oncogenic growth without attenuating in vivo Src kinase activity.	tet	37-49	A kinase (PRKA) anchor protein (gravin) 12	Mus musculus	60-66
16638134-2	2006	We previously used NIH3T3 cells with tetracycline-regulated SSeCKS expression plus a temperature-sensitive v-Src allele to show that SSeCKS re-expression inhibited parameters of v-Src-induced oncogenic growth without attenuating in vivo Src kinase activity.	tet	37-49	A kinase (PRKA) anchor protein (gravin) 12	Mus musculus	133-139
16638134-2	2006	We previously used NIH3T3 cells with tetracycline-regulated SSeCKS expression plus a temperature-sensitive v-Src allele to show that SSeCKS re-expression inhibited parameters of v-Src-induced oncogenic growth without attenuating in vivo Src kinase activity.	tet	37-49	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	180-183
16638134-2	2006	We previously used NIH3T3 cells with tetracycline-regulated SSeCKS expression plus a temperature-sensitive v-Src allele to show that SSeCKS re-expression inhibited parameters of v-Src-induced oncogenic growth without attenuating in vivo Src kinase activity.	tet	37-49	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	180-183
16386398-2	2006	Recently, we have established a transgenic mouse model with inducible neuron-specific expression of TGF-beta1 based on the tetracycline-regulated gene expression system.	tet	123-135	transforming growth factor, beta 1	Mus musculus	100-109
16339398-1	2006	We report the generation of a tetracycline-regulated (Tet ON) transgenic mouse model for acute and chronic expression of the iron regulatory peptide hepcidin in the liver.	tet	30-42	hepcidin antimicrobial peptide	Mus musculus	149-157
16339398-2	2006	We demonstrate that short-term and long-term tetracycline-dependent activation of hepcidin in adult mice leads to hypoferremia and iron-limited erythropoiesis, respectively.	tet	45-57	hepcidin antimicrobial peptide	Mus musculus	82-90
16585195-7	2006	In human cell lines engineered to overexpress or silence FIH in response to tetracycline, we show by quantitative reverse transcription-PCR that a set of hypoxic genes (ca9, phd3, pgk1, and bnip3) respond differently toward FIH expression.	tet	76-88	carbonic anhydrase 9	Homo sapiens	169-172
16585195-7	2006	In human cell lines engineered to overexpress or silence FIH in response to tetracycline, we show by quantitative reverse transcription-PCR that a set of hypoxic genes (ca9, phd3, pgk1, and bnip3) respond differently toward FIH expression.	tet	76-88	BCL2 interacting protein 3	Homo sapiens	190-195
16465375-3	2006	To identify CD43 target genes, gene array analysis was performed using a tetracycline-inducible CD43 expression system in human colon adenocarcinoma SW480 cells.	tet	73-85	sialophorin	Homo sapiens	12-16
16387452-1	2006	We recently reported genome-wide bi-allelic mutagenesis and phenotype-based genetic screening by tetracycline-regulated disruption of the Bloom"s syndrome gene (Blm) in mouse embryonic stem (ES) cells.	tet	97-109	Bloom syndrome, RecQ like helicase	Mus musculus	138-159
16387452-1	2006	We recently reported genome-wide bi-allelic mutagenesis and phenotype-based genetic screening by tetracycline-regulated disruption of the Bloom"s syndrome gene (Blm) in mouse embryonic stem (ES) cells.	tet	97-109	Bloom syndrome, RecQ like helicase	Mus musculus	161-164
16387452-2	2006	However, the same approach was hampered in mouse tissues owing to leaky expression of the Blm gene, which is the major obstacle in the tetracycline regulatory system.	tet	135-147	Bloom syndrome, RecQ like helicase	Mus musculus	90-93
16254139-2	2006	We analyzed the function of GATA-2 by a combined method of tetracycline-dependent conditional gene expression and in vitro hematopoietic differentiation from mouse embryonic stem (ES) cells using OP9 stroma cells (OP9 system).	tet	59-71	GATA binding protein 2	Mus musculus	28-34
16465375-3	2006	To identify CD43 target genes, gene array analysis was performed using a tetracycline-inducible CD43 expression system in human colon adenocarcinoma SW480 cells.	tet	73-85	sialophorin	Homo sapiens	96-100
16428460-3	2006	When expression of ATF3 was regulated under the control of tetracycline system in NP31 cells, they acquired the tubulogenic ability upon ATF3 induction.	tet	59-71	activating transcription factor 3	Rattus norvegicus	19-23
16278083-1	2006	We overexpressed a constitutively active form of the neuregulin receptor ErbB2 (CAErbB2) in skeletal muscle fibers in vivo and in vitro by tetracycline-inducible expression.	tet	139-151	erb-b2 receptor tyrosine kinase 2	Mus musculus	73-78
16139359-4	2006	A rop-containing derivative of pBAD24 (called pBAD322) having the copy number of pBR322 is reported together with derivatives of pBAD322 that encode resistance to chloramphenicol, kanamycin, tetracycline, spectinomycin/streptomycin, gentamycin, or trimethoprim in place of ampicillin.	tet	191-203	regulatory protein Rop	Escherichia coli	2-5
16220550-6	2006	In the present study, we report that tetracycline and minocycline dose-dependently reduce TNF-alpha and IL-6 release by adult human microglia upon stimulation with a combination of Abeta, SAP, and C1q.	tet	37-49	tumor necrosis factor	Homo sapiens	90-99
16220550-6	2006	In the present study, we report that tetracycline and minocycline dose-dependently reduce TNF-alpha and IL-6 release by adult human microglia upon stimulation with a combination of Abeta, SAP, and C1q.	tet	37-49	interleukin 6	Homo sapiens	104-108
16220550-6	2006	In the present study, we report that tetracycline and minocycline dose-dependently reduce TNF-alpha and IL-6 release by adult human microglia upon stimulation with a combination of Abeta, SAP, and C1q.	tet	37-49	amyloid beta precursor protein	Homo sapiens	181-186
16220550-6	2006	In the present study, we report that tetracycline and minocycline dose-dependently reduce TNF-alpha and IL-6 release by adult human microglia upon stimulation with a combination of Abeta, SAP, and C1q.	tet	37-49	amyloid P component, serum	Homo sapiens	188-191
16220550-6	2006	In the present study, we report that tetracycline and minocycline dose-dependently reduce TNF-alpha and IL-6 release by adult human microglia upon stimulation with a combination of Abeta, SAP, and C1q.	tet	37-49	complement C1q A chain	Homo sapiens	197-200
16220550-7	2006	In addition, minocycline and to a lesser extent tetracycline inhibit fibril formation of Abeta as determined in a thioflavin-S-based fluorescence test.	tet	48-60	amyloid beta precursor protein	Homo sapiens	89-94
16150600-2	2006	In order to facilitate studies of pathogenesis and therapeutics, we have generated a new inducible mouse model of HD expressing full-length huntingtin (Htt) using a tetracycline-regulated promoter.	tet	165-177	huntingtin	Mus musculus	140-150
16150600-2	2006	In order to facilitate studies of pathogenesis and therapeutics, we have generated a new inducible mouse model of HD expressing full-length huntingtin (Htt) using a tetracycline-regulated promoter.	tet	165-177	huntingtin	Mus musculus	152-155
16428460-3	2006	When expression of ATF3 was regulated under the control of tetracycline system in NP31 cells, they acquired the tubulogenic ability upon ATF3 induction.	tet	59-71	activating transcription factor 3	Rattus norvegicus	137-141
16300908-8	2006	The overexpression of the anti-HER2/neu mini-antibody-barnase fusion protein decreased the intensity of fluorescence of HEK 293T cells co-transfected with the generated plasmid and a plasmid containing the gene of enhanced green fluorescent protein (pEGFP-N1), in comparison with the intensity of fluorescence of HEK 293T cells transfected with pEGFP-N1, in the absence of tetracycline in the medium.	tet	373-385	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-35
16300908-8	2006	The overexpression of the anti-HER2/neu mini-antibody-barnase fusion protein decreased the intensity of fluorescence of HEK 293T cells co-transfected with the generated plasmid and a plasmid containing the gene of enhanced green fluorescent protein (pEGFP-N1), in comparison with the intensity of fluorescence of HEK 293T cells transfected with pEGFP-N1, in the absence of tetracycline in the medium.	tet	373-385	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-39
16423999-6	2006	Tetracycline-inducible expression of thymosin beta4 antisense RNA caused a partial reversal of the transformed phenotype.	tet	0-12	thymosin, beta 4, X chromosome	Mus musculus	37-51
16629167-6	2006	We recently cloned 1A/+IRE and 2/-IRE DMT1 isoforms to generate HEK293 cell lines that express them in a tetracycline-inducible fashion, then compared induced expression to uninduced expression and to endogenous DMT1 expression.	tet	105-117	solute carrier family 11 member 2	Homo sapiens	38-42
16288910-5	2006	Therefore, to overexpress TGF-beta1 in the artery wall of adult mice, we generated mice that were transgenic for a conditional, tetracycline operator (tetO)-driven TGF-beta1 allele.	tet	128-140	transforming growth factor, beta 1	Mus musculus	164-173
17176614-0	2006	Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: improvement of engraftment following transplantation.	tet	0-12	vascular endothelial growth factor A	Mus musculus	37-43
17176614-6	2006	VEGF secretion was increased in TET and PGK cells, and VEGF delivery resulted in angiogenesis, whereas addition of TC inhibited these processes.	tet	115-117	vascular endothelial growth factor A	Mus musculus	0-4
16288910-6	2006	These mice were viable, and when crossed with mice expressing a tetracycline-regulated transactivator (tTA) in the heart, expressed the TGF-beta1 transgene in a cardiac-restricted and doxycycline-dependent manner.	tet	64-76	transforming growth factor, beta 1	Mus musculus	136-145
17098936-3	2006	In this study, we used a tetracycline-inducible adenoviral vector to express a truncated CBF-B subunit, Bdbd, lacking a transcription activation domain in various mammalian cell lines.	tet	25-37	core-binding factor subunit beta	Homo sapiens	89-94
16446405-4	2006	In this report, we establish a tetracycline-inducible system to study the biochemical and biological effects of a constitutively active Lck mutant with a point mutation at the negative regulatory tyrosine.	tet	31-43	lymphocyte protein tyrosine kinase	Mus musculus	136-139
16945954-3	2006	For this purpose inducible RNAi vectors containing tetracycline (Tet)-responsive derivatives of the H1 promoter for the conditional expression of short hairpin RNA (shRNA) were used to target human polo-like kinase 1 (Plk1), which is overexpressed in a broad spectrum of human tumors.	tet	51-63	polo like kinase 1	Homo sapiens	198-216
16945954-3	2006	For this purpose inducible RNAi vectors containing tetracycline (Tet)-responsive derivatives of the H1 promoter for the conditional expression of short hairpin RNA (shRNA) were used to target human polo-like kinase 1 (Plk1), which is overexpressed in a broad spectrum of human tumors.	tet	51-63	polo like kinase 1	Homo sapiens	218-222
16378104-8	2005	Tetracycline showed a good regulation on the expression of P37 protein, which was not detectable without tetracycline induction.	tet	0-12	nucleoporin 37	Homo sapiens	59-62
16945954-3	2006	For this purpose inducible RNAi vectors containing tetracycline (Tet)-responsive derivatives of the H1 promoter for the conditional expression of short hairpin RNA (shRNA) were used to target human polo-like kinase 1 (Plk1), which is overexpressed in a broad spectrum of human tumors.	tet	65-68	polo like kinase 1	Homo sapiens	198-216
16945954-3	2006	For this purpose inducible RNAi vectors containing tetracycline (Tet)-responsive derivatives of the H1 promoter for the conditional expression of short hairpin RNA (shRNA) were used to target human polo-like kinase 1 (Plk1), which is overexpressed in a broad spectrum of human tumors.	tet	65-68	polo like kinase 1	Homo sapiens	218-222
16140029-4	2006	Co-infection of target cells with AdTetIFN and a second vector encoding a reverse tetracycline controlled transactivator allowed doxycycline (Dox)-regulated IFN-gamma production.	tet	82-94	interferon gamma	Mus musculus	157-166
16297991-4	2005	Using Flp recombinase, we introduced wild type or mutated HNF1beta at a defined chromosomal position allowing a most reproducible induction of the HNF1beta derivatives upon tetracycline addition.	tet	173-185	HNF1 homeobox A	Homo sapiens	58-66
16297991-4	2005	Using Flp recombinase, we introduced wild type or mutated HNF1beta at a defined chromosomal position allowing a most reproducible induction of the HNF1beta derivatives upon tetracycline addition.	tet	173-185	HNF1 homeobox A	Homo sapiens	147-155
16357205-3	2005	Using an embryonic stem cell line engineered with tetracycline-inducible Cdx4, we demonstrate that ectopic Cdx4 expression promotes hematopoietic mesoderm specification, increases hematopoietic progenitor formation, and, together with HoxB4, enhances multilineage hematopoietic engraftment of lethally irradiated adult mice.	tet	50-62	caudal type homeobox 4	Mus musculus	73-77
16357205-3	2005	Using an embryonic stem cell line engineered with tetracycline-inducible Cdx4, we demonstrate that ectopic Cdx4 expression promotes hematopoietic mesoderm specification, increases hematopoietic progenitor formation, and, together with HoxB4, enhances multilineage hematopoietic engraftment of lethally irradiated adult mice.	tet	50-62	caudal type homeobox 4	Mus musculus	107-111
16357205-3	2005	Using an embryonic stem cell line engineered with tetracycline-inducible Cdx4, we demonstrate that ectopic Cdx4 expression promotes hematopoietic mesoderm specification, increases hematopoietic progenitor formation, and, together with HoxB4, enhances multilineage hematopoietic engraftment of lethally irradiated adult mice.	tet	50-62	homeobox B4	Mus musculus	235-240
16378104-8	2005	Tetracycline showed a good regulation on the expression of P37 protein, which was not detectable without tetracycline induction.	tet	105-117	nucleoporin 37	Homo sapiens	59-62
16378104-9	2005	When induced with 2 mg/L tetracycline for 60 hours, the P37 protein expression reached maximum level.	tet	25-37	nucleoporin 37	Homo sapiens	56-59
16007125-4	2005	Conditional expression of Nbk/Bik by applying the inducible tetracycline-responsive expression system triggered apoptosis and enhanced sensitivity to proapoptotic stimuli as to agonistic CD95 activation and to chemotherapeutics etoposide, doxorubicin and pamidronate.	tet	60-72	BCL2 interacting killer	Homo sapiens	26-29
16331330-4	2005	A tetracycline responsive element (TRE) was integrated into the RNA polymerase III promoter region of pBS/U6 that was used to drive specific siRNA to target the novel cytokine receptor-like factor 3 (CRLF3) gene.	tet	2-14	cytokine receptor like factor 3	Homo sapiens	167-198
16331330-4	2005	A tetracycline responsive element (TRE) was integrated into the RNA polymerase III promoter region of pBS/U6 that was used to drive specific siRNA to target the novel cytokine receptor-like factor 3 (CRLF3) gene.	tet	2-14	cytokine receptor like factor 3	Homo sapiens	200-205
16048903-3	2005	To investigate the role of HIF-1 in hypoxia-induced renal epithelial cell death, we generated mice that allow inactivation of HIF-1alpha by tetracycline-inducible Cre-loxP-mediated recombination in primary renal proximal tubule cells (PRPTC), resulting in a suppression of HIF-1-mediated gene transcription during oxygen deprivation.	tet	140-152	hypoxia inducible factor 1, alpha subunit	Mus musculus	126-136
16048903-3	2005	To investigate the role of HIF-1 in hypoxia-induced renal epithelial cell death, we generated mice that allow inactivation of HIF-1alpha by tetracycline-inducible Cre-loxP-mediated recombination in primary renal proximal tubule cells (PRPTC), resulting in a suppression of HIF-1-mediated gene transcription during oxygen deprivation.	tet	140-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-131
16219027-4	2005	This neurotoxicity was antagonized by the semisynthetic tetracycline derivative, minocycline, and the observed neuroprotective effects were associated with the ability of minocycline to suppress NADPH oxidase-derived ROS production and pro-inflammatory cytokine expression, including interleukin-1beta and inducible nitric oxide synthase, from activated microglia.	tet	56-68	interleukin 1 beta	Rattus norvegicus	284-301
16207734-4	2005	Here we show that mice carrying hypomorphic tetracycline-repressible Snail transgenes, that increase Snail expression to 20% above normal levels, exhibit no morphological alterations and develop both epithelial and mesenchymal tumours (leukaemias).	tet	44-56	snail family zinc finger 1	Mus musculus	69-74
16207734-4	2005	Here we show that mice carrying hypomorphic tetracycline-repressible Snail transgenes, that increase Snail expression to 20% above normal levels, exhibit no morphological alterations and develop both epithelial and mesenchymal tumours (leukaemias).	tet	44-56	snail family zinc finger 1	Mus musculus	101-106
16195352-3	2005	By screening a tetracycline-inducible cDNA library in A549 cells for genes that interfere with proliferation, we have identified a fragment of UHRF1 (ubiquitin-like protein containing PHD and RING domains 1), a nuclear RING finger protein, that acts as a dominant negative effector of cell growth.	tet	15-27	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	143-148
16354591-5	2005	To confirm that the formation of glomeruloid bodies was directly dependent on Ang1, we performed experiments where levels of Ang1 expression were regulated under tetracycline control, and we found a direct correlation between levels of Ang1 expression and the occurrence of glomeruloid bodies in xenografts.	tet	162-174	angiopoietin 1	Homo sapiens	125-129
16354591-5	2005	To confirm that the formation of glomeruloid bodies was directly dependent on Ang1, we performed experiments where levels of Ang1 expression were regulated under tetracycline control, and we found a direct correlation between levels of Ang1 expression and the occurrence of glomeruloid bodies in xenografts.	tet	162-174	angiopoietin 1	Homo sapiens	125-129
16315096-3	2005	In an attempt to identify a function for Krct, we have generated a doxycycline-dependent transgenic mouse model that permits the inducible overexpression of Krct in the mammary glands of mice treated with tetracycline derivatives.	tet	205-217	serine/threonine kinase 16	Mus musculus	157-161
16340792-4	2005	METHODS: An adenoviral construct that transfers bcl-2 under the control of a tetracycline inducible promoter was generated (advTetOn bcl-2) and used with a second adenovirus that transfers the repressor protein (advCMV Rep).	tet	77-89	BCL2, apoptosis regulator	Rattus norvegicus	48-53
16007125-4	2005	Conditional expression of Nbk/Bik by applying the inducible tetracycline-responsive expression system triggered apoptosis and enhanced sensitivity to proapoptotic stimuli as to agonistic CD95 activation and to chemotherapeutics etoposide, doxorubicin and pamidronate.	tet	60-72	BCL2 interacting killer	Homo sapiens	30-33
16007125-4	2005	Conditional expression of Nbk/Bik by applying the inducible tetracycline-responsive expression system triggered apoptosis and enhanced sensitivity to proapoptotic stimuli as to agonistic CD95 activation and to chemotherapeutics etoposide, doxorubicin and pamidronate.	tet	60-72	Fas cell surface death receptor	Homo sapiens	187-191
16309425-3	2005	The results showed that reserpine affects the MIC of tetracycline at least 4-fold in all isolates, including those containing the tetM gene.	tet	53-65	TetM	Neisseria gonorrhoeae	130-134
16200064-5	2005	Most notably, by tightly regulating Trp53 knock-down using tetracycline-based systems, we show that cultured mouse fibroblasts can be switched between proliferative and senescent states and that tumors induced by Trp53 suppression and cooperating oncogenes regress upon re-expression of Trp53.	tet	59-71	transformation related protein 53	Mus musculus	36-41
16200064-5	2005	Most notably, by tightly regulating Trp53 knock-down using tetracycline-based systems, we show that cultured mouse fibroblasts can be switched between proliferative and senescent states and that tumors induced by Trp53 suppression and cooperating oncogenes regress upon re-expression of Trp53.	tet	59-71	transformation related protein 53	Mus musculus	213-218
16200064-5	2005	Most notably, by tightly regulating Trp53 knock-down using tetracycline-based systems, we show that cultured mouse fibroblasts can be switched between proliferative and senescent states and that tumors induced by Trp53 suppression and cooperating oncogenes regress upon re-expression of Trp53.	tet	59-71	transformation related protein 53	Mus musculus	213-218
16120440-2	2005	To study the function of p53 in a keratinocyte background, a tetracycline-controlled p53 transgene was introduced into a human SCC cell line (SCC15), lacking endogenous p53.	tet	61-73	tumor protein p53	Homo sapiens	85-88
16120440-2	2005	To study the function of p53 in a keratinocyte background, a tetracycline-controlled p53 transgene was introduced into a human SCC cell line (SCC15), lacking endogenous p53.	tet	61-73	tumor protein p53	Homo sapiens	85-88
16120440-3	2005	Conditional expression of wild-type p53 protein upon withdrawal of tetracycline was accompanied with increased expression of p21(WAF1/Cip1) resulting in reduced cell proliferation.	tet	67-79	tumor protein p53	Homo sapiens	36-39
16197558-2	2005	To identify human PPARs-responsive genes, we established tetracycline-regulated human hepatoblastoma cell lines that can be induced to express each human PPAR and investigated the gene expression profiles of these cells.	tet	57-69	peroxisome proliferator activated receptor alpha	Homo sapiens	18-22
16125275-7	2005	The cDNA of human Cu/Zn superoxide dismutase, a gene of interest for amyotrophic lateral sclerosis, was cloned into pBI-EGFP, downstream of the tetracycline-responsive bidirectional promoter.	tet	144-156	superoxide dismutase 1	Homo sapiens	18-44
15994292-5	2005	Conversely, reconstitution of PTEN in Jurkat cells by using a tetracycline (Tet-on)-inducible expression system down-regulated CXCR4-mediated chemotaxis.	tet	62-74	phosphatase and tensin homolog	Homo sapiens	30-34
15994292-5	2005	Conversely, reconstitution of PTEN in Jurkat cells by using a tetracycline (Tet-on)-inducible expression system down-regulated CXCR4-mediated chemotaxis.	tet	62-74	C-X-C motif chemokine receptor 4	Homo sapiens	127-132
16189114-1	2005	Neisseria gonorrhoeae becomes resistant to tetracycline by two major mechanisms: expression of a plasmid-encoded TetM protein and mutations in endogenous genes (chromosomally mediated resistance).	tet	43-55	TetM	Neisseria gonorrhoeae	113-117
16204029-4	2005	Here, we show that controlled expression of AP-2alpha, using tetracycline-inducible system, increased the chemosensitivity of cancer cells by severalfold by sensitizing cells to undergo apoptosis upon chemotherapy.	tet	61-73	transcription factor AP-2 alpha	Homo sapiens	44-53
16202037-3	2005	The tetracycline-controlled double-transgenic TA(LAP-2)/p(tet)TGF-beta1 mouse provides a model for reversible liver fibrosis.	tet	4-16	leucine aminopeptidase 2, serum	Mus musculus	49-54
16202037-3	2005	The tetracycline-controlled double-transgenic TA(LAP-2)/p(tet)TGF-beta1 mouse provides a model for reversible liver fibrosis.	tet	4-16	transforming growth factor, beta 1	Mus musculus	62-71