PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28801916-8	2018	In whole-cell recordings from hypoxia-responsive PNs, cAMP mimetics enhanced Ih whereas the HCN blocker ZD7288 (2 mum) reversibly inhibited Ih .	ICI D2788	104-110	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	92-95
29925625-5	2018	Here, we show that the pharmacological block of HCN channels with the antagonist ZD7288 applied via reverse microdialysis in the ventrobasal thalamus (VB) of freely moving male Genetic Absence Epilepsy Rats from Strasbourg decreases TC neuron firing and abolishes spontaneous ASs.	ICI D2788	81-87	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	48-51
29971015-7	2018	Results: We found that the HCN channel blocker ZD7288 (50 muM) both induced tonic contractions and increased phasic contraction amplitudes in human and murine detrusor specimens.	ICI D2788	47-53	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	27-30
29971015-10	2018	HCN channels seem to be down-regulated with aging, which is paralleled by an increasing effect of ZD7288 in aging detrusor tissue.	ICI D2788	98-104	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-3
29971015-11	2018	Importantly, the anticonvulsant and HCN channel activator lamotrigine relaxed the detrusor which could be reversed by ZD7288.	ICI D2788	118-124	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	36-39
29460132-3	2018	An experimental study on smooth muscle strips of human upper ureters showed variation in contraction amplitude and frequency after adding ZD7288, a specific blocker of HCN channels.	ICI D2788	138-144	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	168-171
29366880-4	2018	We evaluated nociceptive behaviors after microinjection of the HCN channel blockers ZD7288 or ivabradine into the Gasserian ganglion in rats with trigeminal nerve injury.	ICI D2788	84-90	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	63-66
28673721-6	2017	In 53% (n=21/40 neurons) of the SG neurons examined in SD rats, application of HCN channel blocker, ZD7288 (10muM), decreased the frequency of spontaneous (s) and miniature (m) excitatory postsynaptic currents (EPSCs) by 37+-4% and 33+-4%, respectively.	ICI D2788	100-106	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	79-82
29806529-4	2018	Intrathecal injection of ZD7288, an HCN specific inhibitor, decreased the HCN2 level, as well as weakened the neuropathic pain behaviors compared to naive rats.	ICI D2788	25-31	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	36-39
29806529-4	2018	Intrathecal injection of ZD7288, an HCN specific inhibitor, decreased the HCN2 level, as well as weakened the neuropathic pain behaviors compared to naive rats.	ICI D2788	25-31	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Rattus norvegicus	74-78
28673721-8	2017	Interestingly, the effects of ZD7288 and FSK on sEPSC frequency were replicated in non-GFP-expressing neurons, but not in GFP-expressing GABAergic SG neurons, in GAD67-GFP transgenic C57/BL6 mice.	ICI D2788	30-36	glutamate decarboxylase 1	Rattus norvegicus	162-167
28017718-8	2017	Decreased Abeta, sAPP and APP-CTF levels were also detected after treatment with the HCN2 inhibitor ZD7288.	ICI D2788	100-106	amyloid beta precursor protein	Rattus norvegicus	10-15
28469560-6	2017	In control animals, fast spiking cells showed small sag responses which were reduced by the HCN channel antagonist ZD7288.	ICI D2788	115-121	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	92-95
28166960-3	2017	The aim of the present study was to examine whether blocking HCN channels with a specific blocker ZD7288 would modulate the uterine contractility in a rat model.	ICI D2788	98-104	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	61-64
28166960-0	2017	Effects of ZD7288, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, on term-pregnant rat uterine contractility in vitro.	ICI D2788	11-17	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	74-77
28017718-8	2017	Decreased Abeta, sAPP and APP-CTF levels were also detected after treatment with the HCN2 inhibitor ZD7288.	ICI D2788	100-106	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Rattus norvegicus	85-89
26855147-7	2016	Moreover, the HCN1 expression is increased in the amygdala of rats with peripheral nerve injury and intra-amygdaloidal administration of the HCN channel inhibitor ZD7288 attenuates nociceptive behavior in these rats.	ICI D2788	163-169	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	Rattus norvegicus	14-18
27425615-7	2016	Resonance is inhibited by ZD7288 in wild-type mice and impaired in HCN1 KO mice, suggesting that the HCN1 channel is essential for resonance.	ICI D2788	26-32	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	101-105
27930653-11	2016	Optical recordings of lymph heart showed that the organ"s rhythmicity can be blocked by the HCN channel blocker, ZD7288; an effect also associated with a significant reduction in peak-to-peak local field potential amplitude.	ICI D2788	113-119	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	92-95
27807172-7	2016	Our results show that blockade of HCN channels by ZD7288 decreases MNC firing rate with significant consequences on the release of OT and VP, measured by radioimmunoassay.	ICI D2788	50-56	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	34-37
27542339-4	2016	In this report, we evaluated the effect on nociceptive behaviors after infusion of a HCN channel blocker ZD7288 into the ventral posterolateral (VPL) nucleus of the thalamus in rats with neuropathic pain or monoarthritis.	ICI D2788	105-111	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	85-88
27146984-7	2016	Cyclic nucleotide binding to HCN channels was simulated by blocking native Ih with ZD7288, followed by reconstitution with virtual Ih using a dynamic clamp model of the voltage clamp data.	ICI D2788	83-89	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	29-32
27329413-6	2016	injection or bilateral intra-accumbens microinjections of non-selective HCN channel blocker ZD7288 (0.3125 and 0.625 mug) significantly reduced both methamphetamine (0.0125 or 0.05 mg/kg/infusion)-induced self-administration under fixed ratio 2 reinforcement and the breakpoint of methamphetamine (0.05 mg/kg/infusion) under progressive ratio reinforcement in rats.	ICI D2788	92-98	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	72-75
27329413-8	2016	injection, bilateral intra-accumbens microinjections of ZD7288 exerted stronger inhibitory effects, suggesting that blockade of HCN channels in the nucleus accumbens reduced the reinforcing effects of and motivation for methamphetamine.	ICI D2788	56-62	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	128-131
27329413-12	2016	Finally, in vivo microdialysis experiments showed that the HCN channel blockade using ZD7288 (0.625 and 1.25 mug, i.c.v.)	ICI D2788	86-92	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	59-62
26855147-7	2016	Moreover, the HCN1 expression is increased in the amygdala of rats with peripheral nerve injury and intra-amygdaloidal administration of the HCN channel inhibitor ZD7288 attenuates nociceptive behavior in these rats.	ICI D2788	163-169	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	14-17
27335562-0	2016	ZD7288, a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.	ICI D2788	0-6	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	20-71
25858108-5	2015	In normal rats, micro-pressure ejection of 0.05mM ZD7288, the selective HCN channel blocker, decreased the frequency of spontaneous firing in 21 out of the 40 pallidal neurons.	ICI D2788	50-56	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	72-75
26254243-7	2015	In voltage-clamp condition, a hyperpolarizing activated inward current sensitive to ZD7288 and capsaicin was significantly increased in neurons from Abeta-treated rats.	ICI D2788	84-90	amyloid beta precursor protein	Rattus norvegicus	149-154
26400952-7	2015	Behaviorally, acute HCN channel blockade by local injection of ZD7288 in the mPFC of SNI rats induced a decrease in cold allodynia.	ICI D2788	63-69	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	20-23
27047338-5	2016	The membrane impedance was greater in PrP-null neurons, and this difference was abolished by the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker ZD7288 (100 muM).	ICI D2788	171-177	prion protein	Mus musculus	38-41
28219864-8	2016	The two HCN channel blockers CsCl and ZD7288 significantly delayed the latency of rebound depolarization with spike from 45.9-+11.6 ms to 121.6-+51.3 ms (P<0.05) and from 36.2-+10.3 ms to 73.6-+13.6 ms (P<0.05), respectively.	ICI D2788	38-44	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	8-11
25813712-4	2015	Therefore, in the present study we used the mSNA model to investigate whether: (a) expression of HCN1-HCN3 channels is altered in L4 DRG neurons which, in the mSNA model, are essential for transmission of the evoked pain, and which contribute to chronic spontaneous pain, and (b) local (intraplantar) blockade of these HCN channels, with a specific blocker, ZD7288, attenuates chronic spontaneous pain and/or evoked pain in mSNA rats.	ICI D2788	358-364	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	Rattus norvegicus	97-101
25677606-5	2015	Whole-cell patch-clamp techniques and laser confocal microscopy were used to explore the effects of the HCN channel blocker ZD7288 on Ih current and intracellular calcium levels ([Ca(2+)]i) in freshly isolated ICCs.	ICI D2788	124-130	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	104-107
25957031-4	2015	Differentiated mouse Nkx2-5(eGFP/w) cells demonstrated a wide range of spontaneous oscillation rates that could be reduced by ryanodine (10muM), thapsigargin (1muM) and ZD7288 (10muM).	ICI D2788	169-175	NK2 homeobox 5	Mus musculus	21-27
25813712-4	2015	Therefore, in the present study we used the mSNA model to investigate whether: (a) expression of HCN1-HCN3 channels is altered in L4 DRG neurons which, in the mSNA model, are essential for transmission of the evoked pain, and which contribute to chronic spontaneous pain, and (b) local (intraplantar) blockade of these HCN channels, with a specific blocker, ZD7288, attenuates chronic spontaneous pain and/or evoked pain in mSNA rats.	ICI D2788	358-364	hyperpolarization-activated cyclic nucleotide-gated potassium channel 3	Rattus norvegicus	102-106
25813712-4	2015	Therefore, in the present study we used the mSNA model to investigate whether: (a) expression of HCN1-HCN3 channels is altered in L4 DRG neurons which, in the mSNA model, are essential for transmission of the evoked pain, and which contribute to chronic spontaneous pain, and (b) local (intraplantar) blockade of these HCN channels, with a specific blocker, ZD7288, attenuates chronic spontaneous pain and/or evoked pain in mSNA rats.	ICI D2788	358-364	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	97-100
25852481-15	2015	Enhancement of GABAergic network synchronization by ZD 7288 suggests that HCN channels attenuate inhibitory network activity.	ICI D2788	52-59	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	74-77
25970616-7	2015	Blocking HCN1 channels with ZD7288 in vivo evoked kinetic tremors in nontremulous TRMR rats.	ICI D2788	28-34	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	Rattus norvegicus	9-13
24841085-6	2015	In 42 out of the 89 subthalamic nucleus neurons, micropressure ejection of HCN channel inhibitor, ZD7288 (0.05 mM), decreased the spontaneous firing rate from 11.6 +- 1.8 to 5.7 +- 1.3 Hz (P < 0.001).	ICI D2788	98-104	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	75-78
26709376-9	2015	Pre-incubation of HCN channel blocker ZD 7288 opposed the relaxant effect of CL316,243, whereas co-administration of lamotrigine with CL316,243 at equal molar concentrations caused an additive decrease in resting tension.	ICI D2788	38-45	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	18-21
26709376-12	2015	Opposing effects ZD7288 and Lamotrigine in the action of beta3-AR agonist demonstrate possible functional interaction of HCN channels and beta3-AR in detrusor contractility.	ICI D2788	17-23	adrenoceptor beta 3	Rattus norvegicus	57-65
26709376-12	2015	Opposing effects ZD7288 and Lamotrigine in the action of beta3-AR agonist demonstrate possible functional interaction of HCN channels and beta3-AR in detrusor contractility.	ICI D2788	17-23	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	121-124
26709376-12	2015	Opposing effects ZD7288 and Lamotrigine in the action of beta3-AR agonist demonstrate possible functional interaction of HCN channels and beta3-AR in detrusor contractility.	ICI D2788	17-23	adrenoceptor beta 3	Rattus norvegicus	138-146
25042871-8	2014	Their activation was facilitated by cAMP and their amplitudes were decreased by ZD7288 or low extracellular Na(+) concentration, suggesting that they may belong to the family of HCN channels.	ICI D2788	80-86	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	178-181
24659082-0	2014	Low dose ZD7288 attenuates the ischemia/reperfusion-induced impairment of long-term potentiation induction at hippocampal Schaffer collateral-CA1 synapses.	ICI D2788	9-15	carbonic anhydrase 1	Homo sapiens	142-145
24964850-8	2014	ZD7288, a HCN2 channel blocker, could reverse the above changes in neuropathic pain model rats.	ICI D2788	0-6	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Rattus norvegicus	10-14
24659082-4	2014	Our previous study has indicated that the selective HCN channel blocker ZD7288 can produce a dose-dependent inhibition of the induction of LTP at the Schaffer collateral-CA1 synapse of hippocampus by reducing the amount of glutamate released.	ICI D2788	72-78	carbonic anhydrase 1	Homo sapiens	170-173
24659082-8	2014	Administration of low dose ZD7288 (0.25 mug) at 30 min and 3 h after the onset of ischemia attenuated the impairment of LTP induction and alleviated the NR2B and PSD-95 mRNA and protein down-regulation commonly induced by cerebral ischemia/reperfusion injury.	ICI D2788	27-33	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	153-157
24659082-8	2014	Administration of low dose ZD7288 (0.25 mug) at 30 min and 3 h after the onset of ischemia attenuated the impairment of LTP induction and alleviated the NR2B and PSD-95 mRNA and protein down-regulation commonly induced by cerebral ischemia/reperfusion injury.	ICI D2788	27-33	discs large MAGUK scaffold protein 4	Homo sapiens	162-168
24659082-9	2014	These results suggest that low dose ZD7288 can ameliorate the ischemia/reperfusion-induced impairment of synaptic plasticity in the hippocampal CA1 region.	ICI D2788	36-42	carbonic anhydrase 1	Homo sapiens	144-147
24587682-0	2014	ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats.	ICI D2788	0-7	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	12-15
25244004-6	2014	A robust and reversible inhibition of rhodopsin gene transcription by ZD7288 indicated a role of hyperpolarization-activated channels (HCN).	ICI D2788	70-76	rhodopsin	Gallus gallus	38-47
24587682-1	2014	AIM: To investigate the effects of ZD 7288, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, on rats with chronic visceral pain.	ICI D2788	35-42	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	99-102
23375842-7	2013	Our results indicate that after CCI surgery the following changes occur in vlPAG neurons: the expression of HCN1 and HCN2 channels is increased, the amplitude of the hyperpolarization-activated current (Ih) is augmented and its activation curve is shifted to more positive potentials and there is an increase in the frequency of action potential (AP) firing and spontaneous EPSCs that is attenuated by ZD7288, a HCN channel blocker.	ICI D2788	402-408	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	108-112
23864381-6	2013	In the presence of bicuculline (10 muM), HCN channel inhibition with ZD 7288 (20 muM) significantly increased the magnitude (defined as area) of evoked epileptiform events in both L2/3 and L5 neurons.	ICI D2788	69-76	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	41-44
23398435-5	2013	Subsequently, the function of these upregulated channels was verified by the intravlPAG infusion of ZD7288, a specific HCN blocker, which significantly relieved mechanical allodynia and thermal hyperalgesia in CCI animals.	ICI D2788	100-106	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	119-122
23375842-7	2013	Our results indicate that after CCI surgery the following changes occur in vlPAG neurons: the expression of HCN1 and HCN2 channels is increased, the amplitude of the hyperpolarization-activated current (Ih) is augmented and its activation curve is shifted to more positive potentials and there is an increase in the frequency of action potential (AP) firing and spontaneous EPSCs that is attenuated by ZD7288, a HCN channel blocker.	ICI D2788	402-408	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	117-121
23516351-8	2013	This directional summation was dependent on hyperpolarization activated cyclic nucleotide-gated (HCN) channels as blockade with ZD7288 eliminated directionality.	ICI D2788	128-134	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	97-100
23219935-8	2013	In the presence of the specific hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker ZD7288, TDS also enhanced the excitability of Short-OsT neurons, suggesting that young CA1 neurons regulate I(h) channel expression for neuroprotective modulation against epileptogenic conditions.	ICI D2788	106-112	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	32-83
23219935-8	2013	In the presence of the specific hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker ZD7288, TDS also enhanced the excitability of Short-OsT neurons, suggesting that young CA1 neurons regulate I(h) channel expression for neuroprotective modulation against epileptogenic conditions.	ICI D2788	106-112	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	85-88
23219935-8	2013	In the presence of the specific hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker ZD7288, TDS also enhanced the excitability of Short-OsT neurons, suggesting that young CA1 neurons regulate I(h) channel expression for neuroprotective modulation against epileptogenic conditions.	ICI D2788	106-112	carbonic anhydrase 1	Rattus norvegicus	193-196
22989944-3	2012	Here we show that ZD7288 inhibits not only HCN channel currents, but also Na(+) currents in DRG neurons and ZD7288 was confirmed to inhibit Na(+) current in HEK293 cells transfected with Na(v)1.4 plasmids.	ICI D2788	18-24	immunoglobulin lambda variable 2-14	Homo sapiens	187-195
22956791-8	2012	The firing pattern of nerve endings from HCN1(-/-) mice was also affected by ZD7288, which we attribute to the presence of HCN2 channels in the place of HCN1.	ICI D2788	77-83	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	41-45
22956791-8	2012	The firing pattern of nerve endings from HCN1(-/-) mice was also affected by ZD7288, which we attribute to the presence of HCN2 channels in the place of HCN1.	ICI D2788	77-83	hyperpolarization-activated, cyclic nucleotide-gated K+ 2	Mus musculus	123-127
22956791-8	2012	The firing pattern of nerve endings from HCN1(-/-) mice was also affected by ZD7288, which we attribute to the presence of HCN2 channels in the place of HCN1.	ICI D2788	77-83	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	153-157
22989944-3	2012	Here we show that ZD7288 inhibits not only HCN channel currents, but also Na(+) currents in DRG neurons and ZD7288 was confirmed to inhibit Na(+) current in HEK293 cells transfected with Na(v)1.4 plasmids.	ICI D2788	108-114	immunoglobulin lambda variable 2-14	Homo sapiens	187-195
22085695-9	2012	After application of drug ZD7288 (20muM), the resonance of STN neurons was blocked and the spikes evoked by both impedance amplitude profile (ZAP) current and single-frequency sine wave current arose readily at the lowest frequencies, indicating that hyperpolarization-activated cation current (I(h)) generated the resonance and mediated a preferential coupling at frequencies near f(res) between inputs and firing.	ICI D2788	26-32	YLP motif containing 1	Rattus norvegicus	142-145
22446339-4	2012	The effect of the HCN blocker, ZD7288, was investigated using the bladder smooth muscle strip test.	ICI D2788	31-37	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	18-21
22722099-5	2012	We found that ZD7288 inhibited the acquisition of CTA and reduced apomorphine-induced c-Fos expression in the area postrema, indicating the involvement of the cells expressing H-channels in the induction of nausea and/or emesis.	ICI D2788	14-20	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-91
22792490-4	2012	Application of the specific HCN channel blocker ZD7288 (10 muM) before LFS significantly enhanced LTD (62 +- 4%; P < 0.01), showing HCN channels restrain LTD induction.	ICI D2788	48-54	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	28-31
22792490-4	2012	Application of the specific HCN channel blocker ZD7288 (10 muM) before LFS significantly enhanced LTD (62 +- 4%; P < 0.01), showing HCN channels restrain LTD induction.	ICI D2788	48-54	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	135-138
21796099-7	2011	A specific inhibitor of HCN2 (ZD7288) decreased acidification only in intercalated cells from control rats.	ICI D2788	30-36	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Rattus norvegicus	24-28
21185265-8	2011	As expected, blockade of HCN channels by targeted injection of ZD7288 to the BLA increased anxiety-like behavior under elevated plus maze test.	ICI D2788	63-69	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	25-28
20456426-12	2010	Application of the selective hyperpolarization-activated cyclic nucleotide gated (HCN) channel blockers ZD7288 (10 micromol/L) or CsCl (1.0 mmol/L) abolished I(h) and all of the aforementioned functional correlates.	ICI D2788	104-110	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	82-85
20926664-7	2010	The I(h)-specific blocker ZD7288 reduced hyperpolarization-induced sag and rebound potential, decreased GnRH neuron excitability and action potential firing, and hyperpolarized membrane potential in some cells.	ICI D2788	26-32	gonadotropin releasing hormone 1	Mus musculus	104-108
22355569-2	2011	Using in vivo and in vitro whole-cell recordings here we show that mitral cells are extremely heterogeneous in their expression of a rebound depolarization (sag) at hyperpolarized potentials that is mediated by a ZD7288-sensitive current with properties typical of hyperpolarization-activated cyclic nucleotide gated (HCN) channels.	ICI D2788	213-219	S-antigen visual arrestin	Homo sapiens	157-160
18179873-7	2008	The function of these accumulated channels was verified by local application of ZD7288, a specific HCN blocker, which significantly suppressed the ectopic discharges from injured nerve fibers with no effect on impulse conduction.	ICI D2788	80-86	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	99-102
20393063-6	2010	In Kv1.3-/- cells, K(Na) current could even be detected with 0 mM Na(+) internal solutions, provided extracellular Na(+) was present, and this current could be abolished by TTX and ZD7288, blockers of Na(+) influx through voltage-dependent Na(+) channels and H-channels, respectively.	ICI D2788	181-187	potassium voltage-gated channel, shaker-related subfamily, member 3	Mus musculus	3-8
20064502-0	2010	ZD7288-induced suppression of long-term potentiation was attenuated by exogenous NMDA at the Schaffer collateral-CA1 synapse in the rat in vivo.	ICI D2788	0-6	carbonic anhydrase 1	Rattus norvegicus	113-116
20064502-2	2010	Our previous study showed that the selective HCN channels blocker, ZD7288 (4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride) can block the induction of long-term potentiation (LTP) in perforant path-CA3 region in rat hippocampus in vivo.	ICI D2788	67-73	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	45-48
20064502-2	2010	Our previous study showed that the selective HCN channels blocker, ZD7288 (4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride) can block the induction of long-term potentiation (LTP) in perforant path-CA3 region in rat hippocampus in vivo.	ICI D2788	67-73	carbonic anhydrase 3	Rattus norvegicus	227-230
20064502-2	2010	Our previous study showed that the selective HCN channels blocker, ZD7288 (4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride) can block the induction of long-term potentiation (LTP) in perforant path-CA3 region in rat hippocampus in vivo.	ICI D2788	75-151	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	45-48
20064502-2	2010	Our previous study showed that the selective HCN channels blocker, ZD7288 (4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride) can block the induction of long-term potentiation (LTP) in perforant path-CA3 region in rat hippocampus in vivo.	ICI D2788	75-151	carbonic anhydrase 3	Rattus norvegicus	227-230
20064502-3	2010	In the present study, we investigated the effect of ZD7288 on synaptic transmission and high frequency stimulation (HFS)-induced LTP in the Schaffer collateral-CA1 synapse of rat hippocampus in vivo, and examined the possible relations between activation of N-methyl-d-aspartate (NMDA) type of glutamate receptor and HCN channels for induction of LTP.	ICI D2788	52-58	carbonic anhydrase 1	Rattus norvegicus	160-163
20064502-6	2010	The results suggest that ZD7288 has the ability to prevent the induction of LTP at the Schaffer collateral-CA1 synapse of rat hippocampus, and that this inhibitory effect is attenuated by direct activation of the NMDA receptor.	ICI D2788	25-31	carbonic anhydrase 1	Rattus norvegicus	107-110
19756722-2	2009	Bradycardic agents such as ZD7288 that target HCN channels have been developed, but the molecular configuration of their receptor is poorly defined.	ICI D2788	27-33	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	46-49
19322095-2	2009	In this study, we tested the effect of intrathecal ZD7288, an HCN channel inhibitor, and its interaction with intrathecal gabapentin in the rat formalin test.	ICI D2788	51-57	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	62-65
18850083-7	2008	Patch-clamp recording showed hyperpolarisation-activated currents in alpha-TC6 cells, which could be blocked by HCN channel inhibitor ZD7288.	ICI D2788	134-140	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	112-115
18850083-10	2008	Calcium imaging studies showed that blockade of HCN channels by ZD7288 significantly increased intracellular calcium in alpha-TC6 cells, while lamotrigine or the Na(+) channel blocker tetrodotoxin suppressed the effect of ZD7288 on intracellular calcium.	ICI D2788	64-70	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	48-51
18850083-10	2008	Calcium imaging studies showed that blockade of HCN channels by ZD7288 significantly increased intracellular calcium in alpha-TC6 cells, while lamotrigine or the Na(+) channel blocker tetrodotoxin suppressed the effect of ZD7288 on intracellular calcium.	ICI D2788	222-228	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	48-51
18850083-11	2008	Furthermore, we found the HCN channel inhibitors ZD7288 and cilobradine both significantly increased glucagon secretion from rat islets.	ICI D2788	49-55	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	26-29
18524809-7	2008	Furthermore, HCN channel blockers (5 mM cesium chloride and 100 microM ZD7288) significantly reduced HCN currents and increased action potential frequency of the AB neurons in sham and T1D rats.	ICI D2788	71-77	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	13-16
18524809-7	2008	Furthermore, HCN channel blockers (5 mM cesium chloride and 100 microM ZD7288) significantly reduced HCN currents and increased action potential frequency of the AB neurons in sham and T1D rats.	ICI D2788	71-77	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	101-104
18372334-9	2008	ZD7288, a HCN channel blocker, significantly reduced the efficiency of FSK to stimulate GnRH-1 neurons, whereas blockade of PKA with Rp-adenosine-3",5"-cyclic monophosphorothioate triethylammonium did not attenuate the FSK-induced stimulation.	ICI D2788	0-6	gonadotropin releasing hormone 1	Mus musculus	88-94
18162181-5	2008	The known HCN blocker ZD7288 was also found to be more selective for HCN1 over HCN4, while the HCN blocker DK-AH269 was equipotent on HCN4 and HCN1.	ICI D2788	22-28	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	69-73
18513125-0	2008	Septal infusions of the hyperpolarization-activated cyclic nucleotide-gated channel (HCN-channel) blocker ZD7288 impair spontaneous alternation but not inhibitory avoidance.	ICI D2788	106-112	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	85-88
18513125-2	2008	To test this hypothesis, the present experiments determined whether septal infusions of the selective HCN channel blocker ZD7288 would impair performance on two memory tasks that involve the septo-hippocampal system: spontaneous alternation (SA) and continuous multiple inhibitory avoidance (CMIA).	ICI D2788	122-128	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	102-105
18162181-5	2008	The known HCN blocker ZD7288 was also found to be more selective for HCN1 over HCN4, while the HCN blocker DK-AH269 was equipotent on HCN4 and HCN1.	ICI D2788	22-28	hyperpolarization activated cyclic nucleotide gated potassium channel 4	Homo sapiens	79-83
18162181-7	2008	For both HCN1 and HCN4, ZD7288 was most sensitive in lower Cl(-) solutions, while the potency of loperamide was not affected by the differing solutions.	ICI D2788	24-30	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	9-13
18162181-7	2008	For both HCN1 and HCN4, ZD7288 was most sensitive in lower Cl(-) solutions, while the potency of loperamide was not affected by the differing solutions.	ICI D2788	24-30	hyperpolarization activated cyclic nucleotide gated potassium channel 4	Homo sapiens	18-22
17702809-5	2007	Voltage clamp analysis demonstrated that alpha(2)-NA receptor stimulation inhibited a caesium and ZD7288-sensitive hyperpolarization-activated (HCN) inward current.	ICI D2788	98-104	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	144-147
16765328-8	2006	In medium-sized bladder neurons, a selective HCN channel inhibitor, ZD7288, dose-dependently inhibited I(h) currents.	ICI D2788	68-74	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	45-48
17389267-8	2007	Such an intermediate phenotype, similarly observed in 100% of Ad-CGI-HCN- and Ad-CGI-HCN1-Ins-transduced LVCMs, could be readily reversed by ZD7288, hinting at a direct role of I(f).	ICI D2788	141-147	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	Cavia porcellus	85-89
17578902-3	2007	Here, we characterized the effect of the HCN channel blocker, ZD7288 [4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride] on HCN2 channels that were heterologously expressed in Xenopus oocytes.	ICI D2788	62-68	hyperpolarization-activated, cyclic nucleotide-gated K+ 2	Mus musculus	151-155
17578902-3	2007	Here, we characterized the effect of the HCN channel blocker, ZD7288 [4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride] on HCN2 channels that were heterologously expressed in Xenopus oocytes.	ICI D2788	70-146	hyperpolarization-activated, cyclic nucleotide-gated K+ 2	Mus musculus	151-155
17578902-4	2007	A site-directed mutagenesis approach was used to identify specific residues of the mouse HCN2 channel pore that interact with ZD7288.	ICI D2788	126-132	hyperpolarization-activated, cyclic nucleotide-gated K+ 2	Mus musculus	89-93
17578902-5	2007	Two residues (Ala425 and Ile432) located in the S6 transmembrane domain were found to be the primary determinants for block of HCN2 channels by ZD7288.	ICI D2788	144-150	hyperpolarization-activated, cyclic nucleotide-gated K+ 2	Mus musculus	127-131
17578902-6	2007	I432A mutant HCN2 channels were approximately 100-fold less sensitive to block by ZD7288.	ICI D2788	82-88	hyperpolarization-activated, cyclic nucleotide-gated K+ 2	Mus musculus	13-17
17578902-8	2007	HCN1 channels have a Val (Val390) in the equivalent position of Ile432 and are less sensitive to block by ZD7288.	ICI D2788	106-112	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	0-4
17578902-11	2007	An HCN2 homology model based on the bacterial KcsA K(+) channel predicts that the phenyl ring of ZD7288 occupies a hydrophobic cavity formed by Ala425 and Ile432 and that the charged ring aligns with the axis of the inner pore closely corresponding to the localization of K(+) ions observed in the KcsA crystal structure.	ICI D2788	97-103	hyperpolarization-activated, cyclic nucleotide-gated K+ 2	Mus musculus	3-7
17439493-8	2007	Bath application of the HCN channel blocker ZD7288 resulted in an increase in the frequency of mIPSCs but had no effect on their amplitude, implying that HCN channels tonically regulate the release of GABA.	ICI D2788	44-50	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	24-27
17439493-8	2007	Bath application of the HCN channel blocker ZD7288 resulted in an increase in the frequency of mIPSCs but had no effect on their amplitude, implying that HCN channels tonically regulate the release of GABA.	ICI D2788	44-50	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	154-157
16760342-5	2006	Only in the presence of the HCN blocker ZD7288 was the pH-sensitive component typical for a TASK current, i.e., outward rectification and current reversal at the K+ equilibrium potential.	ICI D2788	40-46	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	28-31
16780797-0	2006	ZD7288 inhibits exocytosis in an HCN-independent manner and downstream of voltage-gated calcium influx in pituitary lactotrophs.	ICI D2788	0-6	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	33-36
16780797-8	2006	Agonist and Bay K 8644-stimulated prolactin release was also inhibited by ZD7288, indicating that this compound attenuates the exocytotic pathway downstream of calcium influx.	ICI D2788	74-80	prolactin	Homo sapiens	34-43
16927834-0	2006	ZD7288 inhibits the synaptic transmission in the pathway from perforant pathway fibers to CA3 region in rat hippocampus.	ICI D2788	0-6	carbonic anhydrase 3	Rattus norvegicus	90-93
16927834-1	2006	AIM: To study the effect of ZD7288 on synaptic transmission in the pathway from perforant pathway (PP) fibers to CA3 region in rat hippocampus.	ICI D2788	28-34	carbonic anhydrase 3	Rattus norvegicus	113-116
16927834-4	2006	The effect of ZD7288 and CsCl on the amplitudes of population spike (PS) in CA3 region evoked by stimulation (0.5 Hz) of the perforant pathway (PP) fibers, and the content of amino acids in hippocampal tissue were observed.	ICI D2788	14-20	carbonic anhydrase 3	Rattus norvegicus	76-79
16927834-5	2006	RESULTS: Microinjection of ZD7288 (20, 100 and 200 nmol) and CsCl (1, 5 and 10 micromol) into CA3 region decreased the population spike (PS) amplitudes in a dose-dependent manner.	ICI D2788	27-33	carbonic anhydrase 3	Rattus norvegicus	94-97
16927834-9	2006	CONCLUSION; ZD7288 could obviously inhibit synaptic transmission in the pathway from PP fibers to CA3 region in rat hippocampus, and this action of ZD7288 may be associated with altered contents of amino acids.	ICI D2788	12-18	carbonic anhydrase 3	Rattus norvegicus	98-101
16307610-5	2005	Abrogation of HCN physiological function in CA3, via the selective I(h)-blocker ZD7288, disrupts GDP generation.	ICI D2788	80-86	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	14-17
16446506-7	2006	VIC in both spHCN and HCN2 was blocked rapidly both by ZD7288 (an HCN channel blocker that is thought to bind in the conduction pore) and by application of Cd2+ to channels containing an introduced cysteine in the pore (spHCN-464C or HCN2-436C).	ICI D2788	55-61	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	22-26
16446506-7	2006	VIC in both spHCN and HCN2 was blocked rapidly both by ZD7288 (an HCN channel blocker that is thought to bind in the conduction pore) and by application of Cd2+ to channels containing an introduced cysteine in the pore (spHCN-464C or HCN2-436C).	ICI D2788	55-61	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	14-17
16307610-5	2005	Abrogation of HCN physiological function in CA3, via the selective I(h)-blocker ZD7288, disrupts GDP generation.	ICI D2788	80-86	carbonic anhydrase 3	Rattus norvegicus	44-47
16307610-6	2005	Furthermore, ZD7288 specifically abolishes spontaneous bursting of the CA3 pyramidal cells at frequencies typical of GDPs without major influence on interneuronal firing.	ICI D2788	13-19	carbonic anhydrase 3	Rattus norvegicus	71-74
16043489-7	2005	Like all other HCNs, hHCN3 was inhibited rapidly and reversibly by extracellular cesium and slowly and irreversibly by extracellular applied ZD7288.	ICI D2788	141-147	hyperpolarization activated cyclic nucleotide gated potassium channel 3	Homo sapiens	21-26
15385586-7	2005	However, the membrane response to IFN-beta in the subthreshold range was prevented by ZD7288 (a specific blocker of I(h)) but not by Ni2+, carbachol, or bicuculline, pointing to a dependence on an intact I(h).	ICI D2788	86-92	interferon beta 1	Homo sapiens	34-42
12711715-5	2003	Extracellular application of 70 microM ZD 7288 completely inhibited NMU-induced depolarization.	ICI D2788	39-46	neuromedin U	Rattus norvegicus	68-71
15351778-3	2004	The pharmacological properties of hHCN1-mediated currents resembled those of native hyperpolarization-activated currents (I(h)), that is, blockade by Cs(+) (99% at 5 mm), ZD 7288 (98% at 100 microm) and zatebradine (92% at 10 microm).	ICI D2788	171-178	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	34-39
15351778-4	2004	Inhibition of the hHCN1-mediated current by ZD 7288 was apparently independent of prior channel activation (i.e. non-use-dependent), whereas that induced by zatebradine was use-dependent.	ICI D2788	44-51	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	18-23
12711715-8	2003	Extracellular application of 70 microM ZD 7288 or 3 mM Cs+ blocked IH and the effects of NMU in voltage-clamp.	ICI D2788	39-46	neuromedin U	Rattus norvegicus	89-92
12684461-8	2003	The effects of VIP on membrane conductance were abolished by the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN)-specific antagonist ZD7288, showing that HCN channels are the major target of VIP modulation.	ICI D2788	151-157	vasoactive intestinal peptide	Rattus norvegicus	15-18
12684461-8	2003	The effects of VIP on membrane conductance were abolished by the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN)-specific antagonist ZD7288, showing that HCN channels are the major target of VIP modulation.	ICI D2788	151-157	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	126-129
12684461-8	2003	The effects of VIP on membrane conductance were abolished by the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN)-specific antagonist ZD7288, showing that HCN channels are the major target of VIP modulation.	ICI D2788	151-157	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	172-175
12684461-8	2003	The effects of VIP on membrane conductance were abolished by the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN)-specific antagonist ZD7288, showing that HCN channels are the major target of VIP modulation.	ICI D2788	151-157	vasoactive intestinal peptide	Rattus norvegicus	209-212
12598605-8	2003	Pharmacological blockade of HCN activity using the specific inhibitor ZD7288 reverses abnormal hypersensitivity to light touch and decreases the firing frequency of ectopic discharges originating in Abeta and Adelta fibers by 90 and 40%, respectively, without conduction blockade.	ICI D2788	70-76	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	28-31
12604089-4	2003	Subsequent patch-clamp experiments confirmed the presence of a prominent hyperpolarisation-activated inward current in the principal cells of the CA3 region that was sensitive to caesium chloride and the selective I(h) blocker ZD-7288.Furthermore, in the presence of mAChR or mGluR agonists these cells exhibited a slow membrane potential oscillation that was independent of AMPA receptor-mediated synaptic transmission.	ICI D2788	227-234	carbonic anhydrase 3	Homo sapiens	146-149
11158163-4	2001	ZD7288 blockade of the mammalian mHCN1 channel appeared to require opening of the channel, but strong hyperpolarization disfavored blockade.	ICI D2788	0-6	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	33-38
12424309-9	2002	CA1 cells instead had a prominent Cs(+)- and 4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride-sensitive I(h) and negligible inward rectification, unlike heterotopic cells.	ICI D2788	45-121	carbonic anhydrase 1	Rattus norvegicus	0-3
35008085-4	2022	ZD7288, an Ih inhibitor as well as an HCN channel antagonist, was administered intracerebroventricularly to the adult GAERS groups, and to evaluate their SWD activities, electroencephalography was recorded.	ICI D2788	0-6	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	38-41
9758221-2	1998	Specific block of endogenous Ih using 4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino)pyridinium chloride (ZD7288) (300 microM) abolished the depolarizing "sag" response to negative current steps, markedly increased the latency and shortened the duration of the low-threshold Ca2+ potentials, and decreased the number of action potentials in the burst evoked by the low-threshold Ca2+ potential.	ICI D2788	113-119	S-antigen visual arrestin	Rattus norvegicus	162-165
9359908-0	1997	Action of the hyperpolarization-activated current (Ih) blocker ZD 7288 in hippocampal CA1 neurons.	ICI D2788	63-70	carbonic anhydrase 1	Rattus norvegicus	86-89
9359908-2	1997	ZD 7288 (1-1000 microM) reduced the hyperpolarization-activated current (Ih) in CA1 pyramidal neurons by a voltage-independent blocking mechanism.	ICI D2788	0-7	carbonic anhydrase 1	Rattus norvegicus	80-83
8747199-7	1995	ZD 7288 (10-100 microM) produced a consistent abolition of the electrotonic potential sag with no effect on membrane potential or spike properties.	ICI D2788	0-7	S-arrestin	Cavia porcellus	86-89
8747199-19	1995	Intracellular loading with ZD 7288 also abolished the sag in the electrotonic voltage response and Ih relaxations, suggesting an intracellular site of action.	ICI D2788	27-34	S-arrestin	Cavia porcellus	54-57
34948401-8	2021	These effects were partially blocked by ZD 7288, a selective HCN blocker, and are consistent with decreased excitability associated with antiepileptic actions.	ICI D2788	40-47	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	61-64
8951716-11	1996	Under current-clamp conditions (Vh = -60 mV), ZD7288 induced a membrane hyperpolarization concomitant with an increase in the membrane input resistance and abolished the voltage sag generated by hyperpolarizing current injection.	ICI D2788	46-52	S-antigen visual arrestin	Rattus norvegicus	178-181
34845181-12	2021	Meanwhile, HCN channel inhibitor ZD7288 prevented the above-mentioned therapeutic effects of moxibustion.	ICI D2788	33-39	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	11-14
35610006-6	2022	ZD7288 (a blocker of HCN channel) reduced the analgesic effect of EA from 1.83 +- 0.84 to 0.74 +- 0.20 ( < 0.05), and the expression of CX3CL1 in the spinal cord decreased from 0.52 +- 0.11 to 0.15 +- 0.05 ( < 0.01).	ICI D2788	0-6	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	21-24
35610006-6	2022	ZD7288 (a blocker of HCN channel) reduced the analgesic effect of EA from 1.83 +- 0.84 to 0.74 +- 0.20 ( < 0.05), and the expression of CX3CL1 in the spinal cord decreased from 0.52 +- 0.11 to 0.15 +- 0.05 ( < 0.01).	ICI D2788	0-6	C-X3-C motif chemokine ligand 1	Rattus norvegicus	136-142
35064517-4	2022	For this reason, in rats with chronic constriction injury of sciatic nerve, we evaluated the effect of intrathecal administration of HCN channel blocker ZD7288 on nociceptive behavior and the expression of P2X2 and P2X3 in rat DRG.	ICI D2788	153-159	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	133-136
35064517-10	2022	Intrathecal injection of ZD7288 significantly reversed CCI-induced mechanical hyperalgesia, and attenuated the increased expression of P2X2 and P2X3 receptor in rat DRG, which open up the possibility that the expression of P2X2 and P2X3 receptor in DRG is down-regulated by HCN channel blocker ZD7288 in CCI rats.	ICI D2788	25-31	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	274-277
35372451-12	2022	Furthermore, the HCN1 channel inhibitor ZD7288 significantly protected against anesthesia/surgery-induced anxiety, but without SIRT3/ac-SOD2 expression or oxidative stress changes.	ICI D2788	40-46	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	17-21
34041946-6	2021	The profiles of these blockers were distinct from those of the previously reported HCN channel blockers ivabradine and ZD7288.	ICI D2788	119-125	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	83-86
34052259-4	2021	Moreover, the administration of ZD7288 (the pan-HCN channel inhibitor) rather than 8-Br-cAMP (the non-specific HCN channel agonist) aggravated the CVH symptoms and reduced the phosphorylation level of CaMKII-CREB cascade.	ICI D2788	32-38	cAMP responsive element binding protein 1	Rattus norvegicus	208-212
32990848-2	2020	Stimulation of alpha2-AR in isolated rat hearts against the background of ZD7288 in concentrations of 10-9 M and 3x10-5 M changed the negative dynamics of myocardial inotropy to positive (by 25 and 38%; p<0.05).	ICI D2788	74-80	adenosine A2a receptor	Rattus norvegicus	15-24
33995059-0	2021	The HCN Channel Blocker ZD7288 Induces Emesis in the Least Shrew (Cryptotis parva).	ICI D2788	24-30	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	4-7
33995059-3	2021	The HCN channel blocker ZD7288 has been shown to reduce apomorphine-induced conditioned taste aversion on saccharin preference in rats suggesting potential antinausea/antiemetic effects.	ICI D2788	24-30	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	4-7
32198387-8	2020	The administration of ZD7288 reduced the immobility time and escape latency time in the forced swim test (FST) and water maze test (WMT) with a decreased level of HCN1, upregulated BDNF-mTOR signaling pathways in the PFC and Hip, and synaptic ultrastructure changes in the PFC.	ICI D2788	22-28	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	Rattus norvegicus	163-167
32165274-6	2020	An increase in the phosphorylation of spinal N-methyl-d-aspartate (NMDA) receptor subunit 1 (NR1) after oxaliplatin administration was weakened by ZD7288 pretreatment.	ICI D2788	147-153	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	45-96
32269286-7	2020	Compared with the WT CA1 neurons, the PRMT7 KO CA1 neurons showed a more hyperpolarized resting potential and a higher input resistance, which were occluded by the Ih-current inhibitor ZD7288; these findings were consistent with the decreased Ih and suggested the contribution of Ih-channel dysfunction to the PRMT7 KO phenotypes.	ICI D2788	185-191	carbonic anhydrase 1	Mus musculus	21-24
32269286-7	2020	Compared with the WT CA1 neurons, the PRMT7 KO CA1 neurons showed a more hyperpolarized resting potential and a higher input resistance, which were occluded by the Ih-current inhibitor ZD7288; these findings were consistent with the decreased Ih and suggested the contribution of Ih-channel dysfunction to the PRMT7 KO phenotypes.	ICI D2788	185-191	protein arginine N-methyltransferase 7	Mus musculus	38-43
32269286-7	2020	Compared with the WT CA1 neurons, the PRMT7 KO CA1 neurons showed a more hyperpolarized resting potential and a higher input resistance, which were occluded by the Ih-current inhibitor ZD7288; these findings were consistent with the decreased Ih and suggested the contribution of Ih-channel dysfunction to the PRMT7 KO phenotypes.	ICI D2788	185-191	carbonic anhydrase 1	Mus musculus	47-50
32269286-7	2020	Compared with the WT CA1 neurons, the PRMT7 KO CA1 neurons showed a more hyperpolarized resting potential and a higher input resistance, which were occluded by the Ih-current inhibitor ZD7288; these findings were consistent with the decreased Ih and suggested the contribution of Ih-channel dysfunction to the PRMT7 KO phenotypes.	ICI D2788	185-191	protein arginine N-methyltransferase 7	Mus musculus	310-315
32248813-8	2020	The pharmacological blockade of HCN channels by ZD7288 resulted in cell depolarization with slowly rising intracellular calcium levels, leading to enhanced survival and reduced proliferation rates of resting microglia.	ICI D2788	48-54	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	32-35
32198387-8	2020	The administration of ZD7288 reduced the immobility time and escape latency time in the forced swim test (FST) and water maze test (WMT) with a decreased level of HCN1, upregulated BDNF-mTOR signaling pathways in the PFC and Hip, and synaptic ultrastructure changes in the PFC.	ICI D2788	22-28	brain-derived neurotrophic factor	Rattus norvegicus	181-185
32198387-8	2020	The administration of ZD7288 reduced the immobility time and escape latency time in the forced swim test (FST) and water maze test (WMT) with a decreased level of HCN1, upregulated BDNF-mTOR signaling pathways in the PFC and Hip, and synaptic ultrastructure changes in the PFC.	ICI D2788	22-28	mechanistic target of rapamycin kinase	Rattus norvegicus	186-190
30503615-5	2018	The voltage-dependent HCN channel blocker ZD7288 completely abolished a prominent depolarizing sag potential in response to hyperpolarization, the hallmark of Ih, and hyperpolarized dINs.	ICI D2788	42-48	Axin	Drosophila melanogaster	76-78
32078767-7	2020	Both Ih and the increased Iinst after PDM could be blocked by the HCN blockers Cs+ and ZD7288.	ICI D2788	87-93	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	66-69
31601020-8	2019	Patch-clamp recordings of renal mitochondria and mitochondria from HEK293 cells overexpressing HCN1, HCN2 and HCN3 channels, stained with MitoTracker Green FM, indicated that only HCN3 could produce inwardly K+ currents that were inhibited by ZD7288, a specific blocker of HCN channels.	ICI D2788	243-249	hyperpolarization activated cyclic nucleotide gated potassium channel 3	Homo sapiens	180-184
30940440-0	2019	HCN channel antagonist ZD7288 ameliorates neuropathic pain and associated depression.	ICI D2788	23-29	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	0-3
30940440-6	2019	To address this, the HCN channel inhibitor, ZD7288, was administrated to Wistar Kyoto (WKY) rats after spared nerve injury (SNI).	ICI D2788	44-50	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	21-24
30940440-7	2019	Our findings show that intracerebroventricular injection of ZD7288 concurrently attenuates co-existing nociceptive and depression-like behaviors, and increases glutamicacid decarboxylase (GAD67/65) expression and GABA levels in the hippocampus and thalamus with High-performance liquid chromatography technique.	ICI D2788	60-66	glutamate decarboxylase 1	Rattus norvegicus	188-193
30826524-10	2019	Furthermore, ZD7288, an HCN current (Ih) blocker, attenuated the acupoint sensitization of the ST35 acupoint.	ICI D2788	13-19	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	24-27
31933729-5	2019	After intrathecal injection of ZD-7288 and si-HCN2, both MWT and PWL were significantly increased, while the level of pro-inflammatory factors TNF-alpha, IL-1beta and MCP-1 were decreased in L4-L5 ipsilateral spinal dorsal horn.	ICI D2788	31-38	tumor necrosis factor	Mus musculus	143-152
31933729-5	2019	After intrathecal injection of ZD-7288 and si-HCN2, both MWT and PWL were significantly increased, while the level of pro-inflammatory factors TNF-alpha, IL-1beta and MCP-1 were decreased in L4-L5 ipsilateral spinal dorsal horn.	ICI D2788	31-38	interleukin 1 beta	Mus musculus	154-162
31933729-5	2019	After intrathecal injection of ZD-7288 and si-HCN2, both MWT and PWL were significantly increased, while the level of pro-inflammatory factors TNF-alpha, IL-1beta and MCP-1 were decreased in L4-L5 ipsilateral spinal dorsal horn.	ICI D2788	31-38	mast cell protease 1	Mus musculus	167-172
30503615-6	2018	ZD7288 also affected dIN post-inhibitory rebound firing, upon which locomotor rhythm generation relies, and disrupted locomotor output.	ICI D2788	0-6	Axin	Drosophila melanogaster	21-24
30503615-8	2018	This usAHP, unmasked in dINs by ZD7288, resulted in suprathreshold stimuli failing to evoke swimming at short inter-swim intervals, indicating an important role for Ih in maintaining swim generation capacity and in setting the post-swim refractory period of the network.	ICI D2788	32-38	Axin	Drosophila melanogaster	21-23
30503615-8	2018	This usAHP, unmasked in dINs by ZD7288, resulted in suprathreshold stimuli failing to evoke swimming at short inter-swim intervals, indicating an important role for Ih in maintaining swim generation capacity and in setting the post-swim refractory period of the network.	ICI D2788	32-38	Axin	Drosophila melanogaster	49-51
30503615-8	2018	This usAHP, unmasked in dINs by ZD7288, resulted in suprathreshold stimuli failing to evoke swimming at short inter-swim intervals, indicating an important role for Ih in maintaining swim generation capacity and in setting the post-swim refractory period of the network.	ICI D2788	32-38	Axin	Drosophila melanogaster	49-51
30503615-8	2018	This usAHP, unmasked in dINs by ZD7288, resulted in suprathreshold stimuli failing to evoke swimming at short inter-swim intervals, indicating an important role for Ih in maintaining swim generation capacity and in setting the post-swim refractory period of the network.	ICI D2788	32-38	Axin	Drosophila melanogaster	49-51