PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24628039-1	2014	Melatonin is an indoleamine that is synthesised from tryptophan under the control of the enzymes arylalkylamine N-acetyltransferase (AA-NAT) and acetylserotonin methyltransferase (ASMT).	indolamine	16-27	aralkylamine N-acetyltransferase	Homo sapiens	97-131
24837237-7	2014	Direct interactions between quinolines and the oxygenases of the pathway (especially with the indoleamine (2,3)-dioxygenase and kynurenine-monoxygenase) and indirect influences via the interferon-gamma induced breakdown of tryptophane are discussed, as well as the modifying effect of the already existing neurotoxicity of the single quinoline related drug used.	indolamine	94-105	interferon gamma	Homo sapiens	185-201
24628039-1	2014	Melatonin is an indoleamine that is synthesised from tryptophan under the control of the enzymes arylalkylamine N-acetyltransferase (AA-NAT) and acetylserotonin methyltransferase (ASMT).	indolamine	16-27	aralkylamine N-acetyltransferase	Homo sapiens	133-139
24628039-1	2014	Melatonin is an indoleamine that is synthesised from tryptophan under the control of the enzymes arylalkylamine N-acetyltransferase (AA-NAT) and acetylserotonin methyltransferase (ASMT).	indolamine	16-27	acetylserotonin O-methyltransferase	Homo sapiens	145-178
24628039-1	2014	Melatonin is an indoleamine that is synthesised from tryptophan under the control of the enzymes arylalkylamine N-acetyltransferase (AA-NAT) and acetylserotonin methyltransferase (ASMT).	indolamine	16-27	acetylserotonin O-methyltransferase	Homo sapiens	180-184
23514631-0	2013	Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).	indolamine	15-27	isoprenylcysteine carboxyl methyltransferase	Homo sapiens	109-113
24083022-7	2013	TNF-alpha potentiates interferon-gamma-induced transcriptional activation of indoleamine 2,3-dioxygenase, the rate-limiting enzyme of tryptophan- (TRP-) kynurenine (KYN) metabolism.	indolamine	77-88	tumor necrosis factor	Homo sapiens	0-9
23110416-11	2013	Moreover, the induction of MT1/MT2 receptors after the administration of high doses of melatonin further suggests that the therapeutic value of melatonin may not be restricted to only low doses of the indoleamine.	indolamine	201-212	metallothionein 1	Rattus norvegicus	27-30
23110416-11	2013	Moreover, the induction of MT1/MT2 receptors after the administration of high doses of melatonin further suggests that the therapeutic value of melatonin may not be restricted to only low doses of the indoleamine.	indolamine	201-212	metallothionein 2A	Rattus norvegicus	31-34
23171152-4	2013	For indoleamine analysis, the separation was carried out on a 1.7-mum C18 BEH column and the detection performed by means of mass spectrometry with electrospray ionization in positive ion mode with multiple reaction monitoring.	indolamine	4-15	Bardet-Biedl syndrome 9	Homo sapiens	70-73
24083022-7	2013	TNF-alpha potentiates interferon-gamma-induced transcriptional activation of indoleamine 2,3-dioxygenase, the rate-limiting enzyme of tryptophan- (TRP-) kynurenine (KYN) metabolism.	indolamine	77-88	interferon gamma	Homo sapiens	22-38
21747395-3	2012	In this study, we examined whether part of the variance in OBFC serotonin synthesis is related to polymorphisms of the gene that encodes for the indoleamine"s rate-limiting enzyme in the brain, tryptophan hydroxylase-2 (TPH(2)).	indolamine	145-156	tryptophan hydroxylase 2	Homo sapiens	194-218
21747395-3	2012	In this study, we examined whether part of the variance in OBFC serotonin synthesis is related to polymorphisms of the gene that encodes for the indoleamine"s rate-limiting enzyme in the brain, tryptophan hydroxylase-2 (TPH(2)).	indolamine	145-156	tryptophan hydroxylase 2	Homo sapiens	220-226
22382690-4	2012	RESULTS: Melatonin increases the expression of Fas and its ligand Fas L, this increase being responsible for cell death induced by the indolamine.	indolamine	135-145	Fas ligand	Homo sapiens	66-71
20561084-10	2010	The CD11c(+) cells from the SDLN of mice treated with topical 1,25(OH)(2)D(3) expressed increased levels of indoleamine 2,3-dioxygenase messenger RNA, a molecule by which topical 1,25(OH)(2)D(3) may enhance the ability of DC to control the suppressive function of CD4(+) CD25(+) cells.	indolamine	108-119	integrin subunit alpha X	Homo sapiens	4-9
23406755-7	2012	In pinealectomized rats substituted with melatonin, pineal indole amine was seen to inhibit oxytocin release and stimulate vasopressin secretion.	indolamine	59-71	arginine vasopressin	Rattus norvegicus	123-134
21118329-2	2011	We carried out an extensive review of the literature pertaining to seizures in MS. We propose that an increase in interleukin-18, and its associated induction of indoleamine 2, 3-dioxygenase and quinolinic acid, mediates seizure activity in MS at least in part via an increase in interferon-gamma (IFNg).	indolamine	162-173	interleukin 18	Homo sapiens	114-128
22079284-8	2012	Current knowledge suggests the clinical use of this non-toxic indoleamine in conjunction with other treatments for inhibition of the negative consequences of hyperglycemia for reducing insulin resistance and for regulating the diabetic state.	indolamine	62-73	insulin	Homo sapiens	185-192
21970724-3	2011	Our labeling approach employs a custom-made, QD-tagged indoleamine derivative ligand, IDT318, that is structurally similar to 5-HT and accesses the primary binding site with enhanced human SERT selectivity.	indolamine	55-66	solute carrier family 6 member 4	Homo sapiens	189-193
21659405-10	2011	CONCLUSIONS: We have shown that in addition to melatonin, other structurally related indoleamine compounds have effects on NFkappaB activation and cytokine expression, GSH, mitochondrial membrane potential, and metabolic activity in endothelial cells cultured under conditions mimicking sepsis.	indolamine	85-96	nuclear factor kappa B subunit 1	Homo sapiens	123-131
21445845-1	2011	Human indoleamine 2,3-dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L-tryptophan (L-Trp) and other indoleamine derivatives.	indolamine	6-17	indoleamine 2,3-dioxygenase 1	Homo sapiens	35-39
20801903-8	2010	Purified CD4(+)CD25(+) T cells obtained from co-culture with indoleamine 2,3-dioxygenase-positive leukemic dendritic cells act as regulatory T cells as they inhibit naive T-cell proliferation and impair the complete maturation of normal dendritic cells.	indolamine	61-72	CD4 molecule	Homo sapiens	9-12
20561084-10	2010	The CD11c(+) cells from the SDLN of mice treated with topical 1,25(OH)(2)D(3) expressed increased levels of indoleamine 2,3-dioxygenase messenger RNA, a molecule by which topical 1,25(OH)(2)D(3) may enhance the ability of DC to control the suppressive function of CD4(+) CD25(+) cells.	indolamine	108-119	CD4 antigen	Mus musculus	264-267
20361220-3	2010	Previous studies suggested that the first step of the dioxygenase reaction involves the deprotonation of the indoleamine group of the substrate by an evolutionarily conserved distal histidine residue in TDO and the heme-bound dioxygen in IDO.	indolamine	109-120	tryptophan 2,3-dioxygenase	Homo sapiens	203-206
20534884-6	2010	A further and converging mechanism of cell protection by this indoleamine described in different models seems to lie in the control of damage and signaling function of mitochondria that involves decreased production of reactive oxygen species and activation of the antiapoptotic and redox-sensitive element Bcl2.	indolamine	62-73	BCL2 apoptosis regulator	Homo sapiens	307-311
20361220-3	2010	Previous studies suggested that the first step of the dioxygenase reaction involves the deprotonation of the indoleamine group of the substrate by an evolutionarily conserved distal histidine residue in TDO and the heme-bound dioxygen in IDO.	indolamine	109-120	indoleamine 2,3-dioxygenase 1	Homo sapiens	238-241
20361220-5	2010	Our data suggest that the deprotonation of the indoleamine group of the substrate by either histidine in TDO or heme-bound dioxygen in IDO is not energetically favorable.	indolamine	47-58	tryptophan 2,3-dioxygenase	Homo sapiens	105-108
20361220-5	2010	Our data suggest that the deprotonation of the indoleamine group of the substrate by either histidine in TDO or heme-bound dioxygen in IDO is not energetically favorable.	indolamine	47-58	indoleamine 2,3-dioxygenase 1	Homo sapiens	135-138
20205557-12	2010	Because melatonin reduces constitutive NFKB activation in cultured pineal glands, we propose that this indolamine regulates this transcription factor pathway in the rat pineal gland, but not at the LD transition.	indolamine	103-113	nuclear factor kappa B subunit 1	Rattus norvegicus	39-43
20178337-1	2010	Indoleamine 2,3-dioxygenase (IDO) is a heme-containing dioxygenase involved in the degradation of several indoleamine derivatives and has been indicated as an immunosuppressive.	indolamine	106-117	indoleamine 2,3-dioxygenase 1	Homo sapiens	0-27
20178337-1	2010	Indoleamine 2,3-dioxygenase (IDO) is a heme-containing dioxygenase involved in the degradation of several indoleamine derivatives and has been indicated as an immunosuppressive.	indolamine	106-117	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-32
20018744-3	2010	To uncover the role of protein flexibility and alterations in protein conformation in molecular recognition by Gbetagamma, a method for site-specific (15)N-labeling of Gbeta-Trp residue backbone and indole amines in insect cells was developed.	indolamine	199-212	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	111-116
20459460-6	2010	The indoleamine-induced phosphorylation of p38 MAPK and the effect on cell proliferation were abrogated by the specific inhibitor SB203580.	indolamine	4-15	mitogen-activated protein kinase 14	Homo sapiens	43-51
19928918-0	2010	Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells.	indolamine	0-11	protein kinase C delta	Homo sapiens	151-160
19928918-0	2010	Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells.	indolamine	0-11	signal transducer and activator of transcription 1	Homo sapiens	161-166
18078453-5	2008	This indoleamine may regulate growth and differentiation of pancreatic islets by activating IGF-I and insulin receptor signaling pathways.	indolamine	5-16	insulin-like growth factor 1	Rattus norvegicus	92-97
19890063-0	2009	Comment on "Reduced cytotoxic function of effector CD8+ T cells is responsible for indoleamine 2,3-dioxygenase-dependent immune suppression".	indolamine	83-94	CD8a molecule	Homo sapiens	51-54
19383920-0	2009	Prevention of spontaneous tumor development in a ret transgenic mouse model by ret peptide vaccination with indoleamine 2,3-dioxygenase inhibitor 1-methyl tryptophan.	indolamine	108-119	ret proto-oncogene	Mus musculus	49-52
19383920-0	2009	Prevention of spontaneous tumor development in a ret transgenic mouse model by ret peptide vaccination with indoleamine 2,3-dioxygenase inhibitor 1-methyl tryptophan.	indolamine	108-119	ret proto-oncogene	Mus musculus	79-82
18373554-6	2008	The indoleamine also significantly increased mRNA expression for various HDAC isoforms, including HDAC3, HDAC5, and HDAC7.	indolamine	4-15	histone deacetylase 3	Mus musculus	98-103
18373554-6	2008	The indoleamine also significantly increased mRNA expression for various HDAC isoforms, including HDAC3, HDAC5, and HDAC7.	indolamine	4-15	histone deacetylase 5	Mus musculus	105-110
18373554-6	2008	The indoleamine also significantly increased mRNA expression for various HDAC isoforms, including HDAC3, HDAC5, and HDAC7.	indolamine	4-15	histone deacetylase 7	Mus musculus	116-121
18457922-4	2008	Interestingly, IFN-gamma, but not IFN-alpha/beta, increased expression and activity of the tryptophan-catabolizing enzyme indoleamine (2,3)-dioxygenase.	indolamine	122-133	interferon gamma	Homo sapiens	15-24
18466643-2	2008	A new report in the previous issue of Arthritis Research & Therapy supports this idea by demonstrating that indoleamine 2,3-dioxygenase-expressing dendritic cells in Peyer"s patches from orally tolerized mice suppress T-cell responses via the generation of CD4+CD25+ regulatory T cells.	indolamine	112-123	CD4 antigen	Mus musculus	261-264
19040557-1	2008	Aromatic L-amino acid decarboxylase (AAAD) is an essential enzyme for the formation of catecholamines, indolamines, and trace amines.	indolamine	103-114	dopa decarboxylase	Homo sapiens	0-35
19040557-1	2008	Aromatic L-amino acid decarboxylase (AAAD) is an essential enzyme for the formation of catecholamines, indolamines, and trace amines.	indolamine	103-114	dopa decarboxylase	Homo sapiens	37-41
18078453-5	2008	This indoleamine may regulate growth and differentiation of pancreatic islets by activating IGF-I and insulin receptor signaling pathways.	indolamine	5-16	insulin receptor	Rattus norvegicus	102-118
15996692-1	2005	It is well established that peripheral administration of interleukin-1 (IL-1) and lipopolysaccharide (LPS) can activate the hypothalamo-pituitary-adrenocortical (HPA) axis, alter brain catecholamine and indoleamine metabolism, and affect behavior.	indolamine	203-214	interleukin 1 complex	Mus musculus	57-76
17371545-2	2007	Melatonin inhibits both inducible nitric oxide synthase and inducible mitochondrial nitric oxide synthase activities, a finding related to the antiseptic properties of the indoleamine.	indolamine	172-183	nitric oxide synthase 2, inducible	Mus musculus	24-55
17191041-1	2007	BACKGROUND: Indoleamine (2,3)-dioxygenase (IDO) catalyses the initial, rate-limiting step in the degradation of the essential amino acid tryptophan.	indolamine	12-23	indoleamine 2,3-dioxygenase 1	Homo sapiens	43-46
16511306-1	2006	Indoleamine 2,3-dioxygenase (IDO) is a haem-containing dioxygenase that catalyzes the oxidative cleavage of the pyrrole ring of indoleamines by the insertion of molecular oxygen.	indolamine	128-140	indoleamine 2,3-dioxygenase 1	Homo sapiens	0-27
16511306-1	2006	Indoleamine 2,3-dioxygenase (IDO) is a haem-containing dioxygenase that catalyzes the oxidative cleavage of the pyrrole ring of indoleamines by the insertion of molecular oxygen.	indolamine	128-140	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-32
16424044-8	2006	The antiproliferative effect of the indolamine on these cells is partially abolished when coincubated with the PKC activator 12-O-tetradecanoylphorbol-13-acetate, thus indicating that the ability of melatonin to change cellular redox state may be inactivating the pathway RTK/PKC/Akt/NF-kappaB.	indolamine	36-46	ret proto-oncogene	Rattus norvegicus	272-275
16424044-8	2006	The antiproliferative effect of the indolamine on these cells is partially abolished when coincubated with the PKC activator 12-O-tetradecanoylphorbol-13-acetate, thus indicating that the ability of melatonin to change cellular redox state may be inactivating the pathway RTK/PKC/Akt/NF-kappaB.	indolamine	36-46	AKT serine/threonine kinase 1	Rattus norvegicus	280-283
18063923-1	2007	Immune activation is accompanied by induction of indoleamine (2,3)-dioxygenase (IDO), an enzyme which degrades tryptophan, a phenomenon which plays a role in the pathophysiology of major depression and post-natal depression and anxiety states.	indolamine	49-60	indoleamine 2,3-dioxygenase 1	Homo sapiens	80-83
17985260-1	2007	Melatonin ( N-acetyl-5-methoxytryptamine, aMT) is an indoleamine produced by several organs and tissues including the pineal gland.	indolamine	53-64	aminomethyltransferase	Homo sapiens	42-45
16415089-2	2006	Based on its pharmacology and reported enhancing effects on dopamine metabolism and tyrosine hydroxylase activity, we investigated whether it could modulate the activity of aromatic l-amino acid decarboxylase (AAAD), the second enzyme for the biosynthesis of catecholamines and indoleamines.	indolamine	278-290	dopa decarboxylase	Mus musculus	173-208
16415089-2	2006	Based on its pharmacology and reported enhancing effects on dopamine metabolism and tyrosine hydroxylase activity, we investigated whether it could modulate the activity of aromatic l-amino acid decarboxylase (AAAD), the second enzyme for the biosynthesis of catecholamines and indoleamines.	indolamine	278-290	dopa decarboxylase	Mus musculus	210-214
16140162-0	2005	An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-alpha expression in rat brain.	indolamine	54-65	protein kinase C, alpha	Rattus norvegicus	88-97
16140162-4	2005	In this study, we investigated the effects of acute (7 days) glucose-induced hyperglycemia and sodium acetoacetate (NaAcAc) or ammonium chloride (NH4Cl) induced acidosis on the level of indolamines (5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA)) as well as PKC-alpha expression/activity in discrete areas of rat brain.	indolamine	186-197	protein kinase C, alpha	Rattus norvegicus	278-287
16140162-9	2005	Similarly, the PKC-alpha expression as well as the enzyme activity showed significant increase in HC, MB, PM and CB under glucose-induced hyperglycemia and that changes correlated the changes of indolamines, suggesting that the hyperglycemia may be the major metabolic disorder in diabetic complications.	indolamine	195-206	protein kinase C, alpha	Rattus norvegicus	15-24
15996692-1	2005	It is well established that peripheral administration of interleukin-1 (IL-1) and lipopolysaccharide (LPS) can activate the hypothalamo-pituitary-adrenocortical (HPA) axis, alter brain catecholamine and indoleamine metabolism, and affect behavior.	indolamine	203-214	toll-like receptor 4	Mus musculus	102-105
14711381-4	2004	In a previous study we have shown that an indolamine molecule expresses a moderate binding affinity at the dopamine D2 and serotonin 5-HT1A receptors in in vitro competition binding assays.	indolamine	42-52	5-hydroxytryptamine receptor 1A	Rattus norvegicus	133-139
15683469-9	2005	This aromatase inhibitory effect of melatonin, together with its already known antiestrogenic properties interacting with the estrogen-receptor, makes this indoleamine an interesting tool to be considered in the prevention and treatment of hormone-dependent mammary neoplasias.	indolamine	156-167	estrogen receptor 1	Homo sapiens	126-143
15342107-0	2004	PKC-alpha mediated alterations of indoleamine contents in diabetic rat brain.	indolamine	34-45	protein kinase C, alpha	Rattus norvegicus	0-9
15342107-6	2004	The expressions of PKC-alpha studied by immunoblotting also showed significant changes in ST, HC, MB, PM, CB and CCX that is identical to the changes of both 5-HT and 5-HIAA under similar condition, suggesting that the PKC-alpha may regulate the synthesis and release of indoleamines in diabetic animals.	indolamine	271-283	protein kinase C, alpha	Rattus norvegicus	19-28
15342107-6	2004	The expressions of PKC-alpha studied by immunoblotting also showed significant changes in ST, HC, MB, PM, CB and CCX that is identical to the changes of both 5-HT and 5-HIAA under similar condition, suggesting that the PKC-alpha may regulate the synthesis and release of indoleamines in diabetic animals.	indolamine	271-283	protein kinase C, alpha	Rattus norvegicus	219-228
15746263-4	2005	In the profile, RNA expressions of indoleamine 2,3-dioxygenase, that is known to induce anergy of T cells and natural killer cells in protecting fetal rejection; many kinds of proteasomes that were reported to trigger cytokine production by inhibiting suppressors of NF-kappaB; and several kinds of chemokines increased, whereas RNA expression of superoxide dismutase 1 decreased, which was unexpected but considered worthy of notice.	indolamine	35-46	nuclear factor kappa B subunit 1	Homo sapiens	267-276
15746263-4	2005	In the profile, RNA expressions of indoleamine 2,3-dioxygenase, that is known to induce anergy of T cells and natural killer cells in protecting fetal rejection; many kinds of proteasomes that were reported to trigger cytokine production by inhibiting suppressors of NF-kappaB; and several kinds of chemokines increased, whereas RNA expression of superoxide dismutase 1 decreased, which was unexpected but considered worthy of notice.	indolamine	35-46	superoxide dismutase 1	Homo sapiens	347-369
15298668-2	2004	This indolamine causes CaM subcellular redistribution in epithelial MDCK and MCF-7 cells, and selectively activates protein kinase C alpha (PKC alpha) in neuronal N1E-115 cells.	indolamine	5-15	protein kinase C alpha	Homo sapiens	116-138
15298668-2	2004	This indolamine causes CaM subcellular redistribution in epithelial MDCK and MCF-7 cells, and selectively activates protein kinase C alpha (PKC alpha) in neuronal N1E-115 cells.	indolamine	5-15	protein kinase C alpha	Homo sapiens	140-149
15302611-2	2004	Th1-type cytokine interferon-gamma (IFN-gamma) induces neopterin production as well as tryptophan degradation via indoleamine (2,3)-dioxygenase (IDO), and quantification of these biochemical alterations allows one to monitor immune system activation.	indolamine	114-125	interferon gamma	Homo sapiens	36-45
15302611-2	2004	Th1-type cytokine interferon-gamma (IFN-gamma) induces neopterin production as well as tryptophan degradation via indoleamine (2,3)-dioxygenase (IDO), and quantification of these biochemical alterations allows one to monitor immune system activation.	indolamine	114-125	indoleamine 2,3-dioxygenase 1	Homo sapiens	145-148
12814390-2	2003	Cytokine interferon-gamma, which is released during cell-mediated immune responses, induces indoleamine (2,3)-dioxygenase (IDO), an enzyme degrading tryptophan to kynurenine.	indolamine	92-103	interferon gamma	Homo sapiens	9-25
12814390-2	2003	Cytokine interferon-gamma, which is released during cell-mediated immune responses, induces indoleamine (2,3)-dioxygenase (IDO), an enzyme degrading tryptophan to kynurenine.	indolamine	92-103	indoleamine 2,3-dioxygenase 1	Homo sapiens	123-126
11953396-4	2002	The inhibitory effect of IFN-gamma appears to be due in part to expression of host cell indoleamine 2,3-dioxygenase activity, since inhibition of apoptosis could be partially reversed through coincubation with exogenous tryptophan.	indolamine	88-99	interferon gamma	Mus musculus	25-34
12603316-10	2003	The results suggest that calreticulin may represent a new class of high-affinity melatonin binding sites involved in some functions of the indoleamine including genomic regulation.	indolamine	139-150	calreticulin	Rattus norvegicus	25-37
12488534-0	2003	Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy.	indolamine	51-62	5-hydroxytryptamine receptor 2A	Homo sapiens	106-131
12047348-1	2002	BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the decarboxylation step in both the catecholamine and indoleamine synthetic pathways.	indolamine	140-151	dopa decarboxylase	Rattus norvegicus	12-47
12047348-1	2002	BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the decarboxylation step in both the catecholamine and indoleamine synthetic pathways.	indolamine	140-151	dopa decarboxylase	Rattus norvegicus	49-53
11838318-1	2001	Endotoxin (lipopolysaccharide, LPS) is known to activate the hypothalamo-pituitary adrenocortical axis, as well as norepinephrine and indolamine metabolism.	indolamine	134-144	toll-like receptor 4	Mus musculus	31-34
11602621-2	2001	Here we found that PA-SMCs from patients with PPH grow faster than PA-SMCs from controls when stimulated by serotonin or serum and that these effects are due to increased expression of the serotonin transporter (5-HTT), which mediates internalization of indoleamine.	indolamine	254-265	solute carrier family 6 member 4	Homo sapiens	189-210
11555166-3	2001	A decrease of heme loss and accumulation of soluble methemoglobin (met-Hb) are explained in terms of the interaction of the indoleamine with perferryl Hb (Hb[Fe(IV)=O]), a highly reactive Hb-derived radical species responsible for the irreversible Hb degradation.	indolamine	124-135	hemoglobin subunit gamma 2	Homo sapiens	52-65
11021986-2	2000	We measured changes in extracellular concentrations of catecholamine and indoleamines in freely moving rats in response to administration of CRF1 antagonist CP-154,526 by using in vivo microdialysis.	indolamine	73-85	corticotropin releasing hormone receptor 1	Rattus norvegicus	141-145
11388614-3	2001	Using human peripheral blood-derived mononuclear cells in vitro, such toxins were shown to induce neopterin production and degradation of the amino acid tryptophan to metabolites such as kynurenine by activating indoleamine (2,3)-dioxygenase via interferon-gamma.	indolamine	212-223	interferon gamma	Homo sapiens	246-262
10899948-1	2000	Aromatic L-amino acid decarboxylase (AAAD), an enzyme required for the synthesis of catecholamines, indoleamines, and trace amines, is rapidly activated by cyclic AMP-dependent pathways in striatum and midbrain in vivo, suggesting enzyme phosphorylation.	indolamine	100-112	dopa decarboxylase	Mus musculus	0-35
10899948-1	2000	Aromatic L-amino acid decarboxylase (AAAD), an enzyme required for the synthesis of catecholamines, indoleamines, and trace amines, is rapidly activated by cyclic AMP-dependent pathways in striatum and midbrain in vivo, suggesting enzyme phosphorylation.	indolamine	100-112	dopa decarboxylase	Mus musculus	37-41
10719243-1	2000	Indoleamine 2,3-dioxygenase (IDO) reacts with either oxygen or superoxide and tryptophan (trp) or other indoleamines while tryptophan 2,3-dioxygenase (TDO) reacts with oxygen and is specific for trp.	indolamine	104-116	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	0-27
10834318-3	2000	IFN-gamma stimulates the enzyme indoleamine (2,3)-dioxygenase (IDO) converting tryptophan to the metabolite kynurenine which in macrophages is subsequently degraded to other, partly neurotoxic compounds like quinolinic acid, and finally to nicrotinamides.	indolamine	32-43	interferon gamma	Homo sapiens	0-9
10834318-3	2000	IFN-gamma stimulates the enzyme indoleamine (2,3)-dioxygenase (IDO) converting tryptophan to the metabolite kynurenine which in macrophages is subsequently degraded to other, partly neurotoxic compounds like quinolinic acid, and finally to nicrotinamides.	indolamine	32-43	indoleamine 2,3-dioxygenase 1	Homo sapiens	63-66
10719243-1	2000	Indoleamine 2,3-dioxygenase (IDO) reacts with either oxygen or superoxide and tryptophan (trp) or other indoleamines while tryptophan 2,3-dioxygenase (TDO) reacts with oxygen and is specific for trp.	indolamine	104-116	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	29-32
10638639-0	2000	The paradox of 5-methoxy-N,N-dimethyltryptamine: an indoleamine hallucinogen that induces stimulus control via 5-HT1A receptors.	indolamine	52-63	5-hydroxytryptamine receptor 1A	Rattus norvegicus	111-117
10601817-1	2000	Endotoxin (lipopolysaccharide, LPS) and interleukin-1 (IL-1) are known to activate the hypothalamo-pituitary- adrenocortical (HPA) axis, as well as brain norepinephrine (NE) and indoleamine metabolism.	indolamine	178-189	interleukin 1 complex	Mus musculus	55-59
10372512-9	1999	We concluded that a drug wash-out period after deprenyl treatment differentially affects the metabolism of catecholamines and indoleamine depending on the region of the brain and that this effect may be due to variation in the kinetics of MAO inhibition.	indolamine	126-137	monoamine oxidase A	Rattus norvegicus	239-242
10432484-2	1999	There is now converging evidence from biochemical, electrophysiological, and behavioral studies that the two major classes of psychedelic hallucinogens, the indoleamines (e.g., LSD) and the phenethylamines (e.g., mescaline), have a common site of action as partial agonists at 5-HT2A and other 5-HT2 receptors in the central nervous system.	indolamine	157-169	5-hydroxytryptamine receptor 2A	Homo sapiens	277-283
10601817-1	2000	Endotoxin (lipopolysaccharide, LPS) and interleukin-1 (IL-1) are known to activate the hypothalamo-pituitary- adrenocortical (HPA) axis, as well as brain norepinephrine (NE) and indoleamine metabolism.	indolamine	178-189	interleukin 1 complex	Mus musculus	40-53
10510170-6	1999	We conclude that phenethylamine and indoleamine hallucinogens may exert their hallucinogenic effect by interacting with 5-HT2A receptors via a Ca2+/CaM-KII-dependent signal transduction pathway as partial agonists and modulating the NMDA receptors-mediated sensory, perceptual, affective and cognitive processes.	indolamine	36-47	5-hydroxytryptamine receptor 2A	Rattus norvegicus	120-126
10485583-4	1999	The results show that Lurcher mutants retain higher concentrations of L-tryptophan and total indoleamines, but that 5-HT is probably stored in a non-releasable compartment.	indolamine	93-105	glutamate receptor, ionotropic, delta 2	Mus musculus	22-29
10485583-5	1999	In the particular case of the hypoplastic cerebellum, the reorganization of 5-HT nerve terminals leads to an accrued indoleamine synthesis, indicating that the Lurcher mutants can accumulate 5-HT, but do not utilize it efficiently in synaptic transmission.	indolamine	117-128	glutamate receptor, ionotropic, delta 2	Mus musculus	160-167
9838142-5	1998	The SR activity of the recombinant protein was inhibited by two indoleamines, N-acetyl serotonin and melatonin.	indolamine	64-76	Sepiapterin reductase	Drosophila melanogaster	4-6
10731095-1	1999	The heme enzyme indoleamine 2,3-dioxygenase (IDO) oxidizes the pyrrole moiety of L-tryptophan (Trp) and other indoleamines and represents the initial and rate-limiting enzyme of the kynurenine (Kyn) pathway.	indolamine	110-122	indoleamine 2,3-dioxygenase 1	Homo sapiens	16-43
10731095-1	1999	The heme enzyme indoleamine 2,3-dioxygenase (IDO) oxidizes the pyrrole moiety of L-tryptophan (Trp) and other indoleamines and represents the initial and rate-limiting enzyme of the kynurenine (Kyn) pathway.	indolamine	110-122	indoleamine 2,3-dioxygenase 1	Homo sapiens	45-48
10036306-1	1999	Arylalkylamine N-acetyltransferase (AA-NAT, E. C. 2.3.1.87) is the enzyme that catalyzes the transfer of an acetyl group from acetyl-CoA to serotonin to form N-acetylserotonin (NAS) in the indoleamine biosynthetic pathway.	indolamine	189-200	serotonin N-acetyltransferase	Bos taurus	0-34
10036306-1	1999	Arylalkylamine N-acetyltransferase (AA-NAT, E. C. 2.3.1.87) is the enzyme that catalyzes the transfer of an acetyl group from acetyl-CoA to serotonin to form N-acetylserotonin (NAS) in the indoleamine biosynthetic pathway.	indolamine	189-200	serotonin N-acetyltransferase	Bos taurus	36-42
9878816-0	1999	The role of interleukin-6 in the activation of the hypothalamo-pituitary-adrenocortical axis and brain indoleamines by endotoxin and interleukin-1 beta.	indolamine	103-115	interleukin 6	Mus musculus	12-25
9878816-0	1999	The role of interleukin-6 in the activation of the hypothalamo-pituitary-adrenocortical axis and brain indoleamines by endotoxin and interleukin-1 beta.	indolamine	103-115	interleukin 1 beta	Mus musculus	133-151
9804794-0	1998	Indoleamine analogs as probes of the substrate selectivity and catalytic mechanism of serotonin N-acetyltransferase.	indolamine	0-11	aralkylamine N-acetyltransferase	Homo sapiens	86-115
9804794-2	1998	This study evaluates a series of indoleamine analogs as alternate substrates of AANAT.	indolamine	33-44	aralkylamine N-acetyltransferase	Homo sapiens	80-85
9739003-1	1998	It has been shown that 5-hydroxytryptamine and melatonin, an indoleamine for which 5-hydroxytryptamine is a precursor, influence the release of vasopressin and oxytocin from the rat hypothalamus both in vivo and in vitro.	indolamine	61-72	arginine vasopressin	Rattus norvegicus	144-155
9726842-6	1998	We found that the IFNgamma or the IFNgamma/TNF alpha induced activation of indoleamine 2,3-dioxygenase is responsible for the inhibition of streptococcal growth, since the addition of supplemental L-tryptophan completely blocks the IFNgamma induced bacteriostasis.	indolamine	75-86	interferon gamma	Homo sapiens	18-26
9726842-6	1998	We found that the IFNgamma or the IFNgamma/TNF alpha induced activation of indoleamine 2,3-dioxygenase is responsible for the inhibition of streptococcal growth, since the addition of supplemental L-tryptophan completely blocks the IFNgamma induced bacteriostasis.	indolamine	75-86	interferon gamma	Homo sapiens	34-42
9726842-6	1998	We found that the IFNgamma or the IFNgamma/TNF alpha induced activation of indoleamine 2,3-dioxygenase is responsible for the inhibition of streptococcal growth, since the addition of supplemental L-tryptophan completely blocks the IFNgamma induced bacteriostasis.	indolamine	75-86	tumor necrosis factor	Homo sapiens	43-52
9726842-6	1998	We found that the IFNgamma or the IFNgamma/TNF alpha induced activation of indoleamine 2,3-dioxygenase is responsible for the inhibition of streptococcal growth, since the addition of supplemental L-tryptophan completely blocks the IFNgamma induced bacteriostasis.	indolamine	75-86	interferon gamma	Homo sapiens	34-42
7821394-6	1994	Striatal indoleamine metabolism, determined by the ratio of 5-hydroxyindoleacetic acid (5HIAA)/serotonin was also elevated by NT-4/5 and BDNF in the caudate-putamen (29, 32%), and the 5HIAA content of the substantia nigra was elevated by both factors (43, 40%).	indolamine	9-20	neurotrophin 4	Rattus norvegicus	126-132
9464467-0	1998	Atrial natriuretic peptide mediated alterations in catecholamine and indoleamine turnover in the nucleus of the solitary tract of rats.	indolamine	69-80	natriuretic peptide A	Rattus norvegicus	0-26
8700116-8	1996	Mutation of this locus in the 5-HT2A receptor decreased the affinity of all indoleamines, whereas the interchange mutation of the 5-HT2C receptor did not affect indoleamine affinity.	indolamine	76-88	5-hydroxytryptamine receptor 2A	Homo sapiens	30-45
8700116-8	1996	Mutation of this locus in the 5-HT2A receptor decreased the affinity of all indoleamines, whereas the interchange mutation of the 5-HT2C receptor did not affect indoleamine affinity.	indolamine	76-87	5-hydroxytryptamine receptor 2A	Homo sapiens	30-45
8700116-9	1996	These results are consistent with a direct interaction between this side chain and indoleamines for the 5-HT2A receptor but not for the 5-HT2C receptor.	indolamine	83-95	5-hydroxytryptamine receptor 2A	Homo sapiens	104-119
8748393-2	1995	Three structural classes of compounds have been described to stimulate increases in phosphoinositide (PI) hydrolysis at the 5-HT2C receptor site: phenylpiperazines, phenylalkylamines, and indolamines.	indolamine	188-199	5-hydroxytryptamine receptor 2C	Homo sapiens	124-130
8584618-9	1995	In addition, these results suggest that 5-HT2A agonist activity may be required, but is not in itself sufficient, for indolamine and phenylalkglamine compounds to elicit hallucinations in humans.	indolamine	118-128	5-hydroxytryptamine receptor 2A	Homo sapiens	40-46
7708056-10	1994	Thus, it appears that the antiproliferative actions of this pineal indoleamine are mediated, at least in part, through the suppression of the transcription of the ER gene in MCF-7 human breast cancer cells.	indolamine	67-78	estrogen receptor 1	Homo sapiens	163-165
9682270-0	1998	Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine.	indolamine	40-52	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	14-20
9682270-11	1998	However, the metabolism of both indoleamines was not significantly inhibited with the CYP1A2-specific inhibitor furafylline, thus indicating that the inhibition of CYP1A2 was not related to metabolic activity of the CYP1A2 enzyme on serotonin or tryptamine.	indolamine	32-44	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	164-170
9682270-11	1998	However, the metabolism of both indoleamines was not significantly inhibited with the CYP1A2-specific inhibitor furafylline, thus indicating that the inhibition of CYP1A2 was not related to metabolic activity of the CYP1A2 enzyme on serotonin or tryptamine.	indolamine	32-44	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	164-170
9682270-15	1998	In addition, the influence of indoleamines on CYP1A2 activity might be partly responsible for a number of associations of CYP1A2 activity with nutritional and environmental factors.	indolamine	30-42	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	46-52
9682270-15	1998	In addition, the influence of indoleamines on CYP1A2 activity might be partly responsible for a number of associations of CYP1A2 activity with nutritional and environmental factors.	indolamine	30-42	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	122-128
9332722-1	1997	GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the formation of tetrahydrobiopterin, the cofactor for catecholamine, indolamine and nitric oxide biosynthesis.	indolamine	130-140	GTP cyclohydrolase 1	Rattus norvegicus	0-20
9332722-1	1997	GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the formation of tetrahydrobiopterin, the cofactor for catecholamine, indolamine and nitric oxide biosynthesis.	indolamine	130-140	GTP cyclohydrolase 1	Rattus norvegicus	22-27
9787239-1	1997	GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, the cofactor for catecholamine, indolamine and nitric oxide biosynthesis.	indolamine	133-143	GTP cyclohydrolase 1	Rattus norvegicus	0-20
9787239-1	1997	GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, the cofactor for catecholamine, indolamine and nitric oxide biosynthesis.	indolamine	133-143	GTP cyclohydrolase 1	Rattus norvegicus	22-27
8869564-7	1996	There was a significant and positive correlation (r = +0.86) between plasma levels of BDNF and serotonin, an indoleamine that is specifically released from activated platelets.	indolamine	109-120	brain derived neurotrophic factor	Homo sapiens	86-90
8840334-3	1995	IL-6 and TNF alpha may also activate the HPA axis, and IL-6 activates cerebral indolamines.	indolamine	79-90	interleukin 6	Homo sapiens	55-59
7635243-2	1995	Aromatic L-amino acid decarboxylase is the enzyme responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways.	indolamine	125-135	dopa decarboxylase	Homo sapiens	0-35
7615820-5	1995	In addition, incubation of fibroblasts with IFN-gamma resulted in a marked increase in cellular indoleamine 2,3-dioxygenase (IDO) mRNA, a > 90% depletion of tryptophan, and a corresponding > 30-fold increase in the tryptophan metabolite kynurenine in the culture media.	indolamine	96-107	interferon gamma	Homo sapiens	44-53
7615820-5	1995	In addition, incubation of fibroblasts with IFN-gamma resulted in a marked increase in cellular indoleamine 2,3-dioxygenase (IDO) mRNA, a > 90% depletion of tryptophan, and a corresponding > 30-fold increase in the tryptophan metabolite kynurenine in the culture media.	indolamine	96-107	indoleamine 2,3-dioxygenase 1	Homo sapiens	125-128
7705397-6	1995	Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase.	indolamine	230-241	interferon gamma	Homo sapiens	44-53
7705397-6	1995	Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase.	indolamine	230-241	interferon gamma	Homo sapiens	166-175
7821394-6	1994	Striatal indoleamine metabolism, determined by the ratio of 5-hydroxyindoleacetic acid (5HIAA)/serotonin was also elevated by NT-4/5 and BDNF in the caudate-putamen (29, 32%), and the 5HIAA content of the substantia nigra was elevated by both factors (43, 40%).	indolamine	9-20	brain-derived neurotrophic factor	Rattus norvegicus	137-141
7812764-1	1994	The effects of condensation products of dopamine and indoleamines on the activity of tryptophan hydroxylase (TPH) were evaluated to determine the structures associated with modulation of this enzyme activity.	indolamine	53-65	tryptophan hydroxylase 1	Rattus norvegicus	85-107
7812764-1	1994	The effects of condensation products of dopamine and indoleamines on the activity of tryptophan hydroxylase (TPH) were evaluated to determine the structures associated with modulation of this enzyme activity.	indolamine	53-65	tryptophan hydroxylase 1	Rattus norvegicus	109-112
7812764-10	1994	The selective inhibition of TPH by dopamine-derived catechol isoquinolines was discussed in relationship to the interactions between catecholamines, indoleamines and their metabolites in the brain under physiological and pathological conditions.	indolamine	149-161	tryptophan hydroxylase 1	Rattus norvegicus	28-31
3148005-4	1988	Therefore, the stimulated IFN-gamma production of serotonin and melatonin by lymphocytes and macrophages and the inhibition of IFN-gamma synthesis by these indoleamines suggest a hypothesis for an immunoregulatory circuit.	indolamine	156-168	interferon gamma	Homo sapiens	127-136
8103077-1	1993	GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, the reduced pteridine cofactor required for catecholamine (CA), indoleamine, and nitric oxide biosynthesis.	indolamine	165-176	GTP cyclohydrolase 1	Rattus norvegicus	0-20
8103077-1	1993	GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, the reduced pteridine cofactor required for catecholamine (CA), indoleamine, and nitric oxide biosynthesis.	indolamine	165-176	GTP cyclohydrolase 1	Rattus norvegicus	22-27
1465184-6	1992	Interferon-gamma, pokeweed mitogen and lipopolysaccharide induced indoleamine-2,3-dioxygenase, the first enzyme of the kynurenine pathway, and increased both L-kynurenine and quinolinic acid concentrations of brain and systemic tissues, particularly in the lung, gastrointestinal tract and spleen.	indolamine	66-77	interferon gamma	Mus musculus	0-16
1540578-1	1992	Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines.	indolamine	266-278	dopa decarboxylase	Homo sapiens	0-35
1540578-1	1992	Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines.	indolamine	266-278	dopa decarboxylase	Homo sapiens	37-41
2128302-5	1990	From the data it appears that reduced tryptophan in patients may result from induction of indoleamine (2,3)-dioxygenase by IFN-gamma.	indolamine	90-101	interferon gamma	Homo sapiens	123-132
8469423-0	1993	Localization of mRNA encoding the indolamine synthesizing enzyme, hydroxyindole-O-methyltransferase, in chicken pineal gland and retina by in situ hybridization.	indolamine	34-44	acetylserotonin O-methyltransferase	Gallus gallus	66-99
7678287-1	1993	In vivo microdialysis was used to measure changes in extracellular concentrations of catecholamines and indoleamines in freely moving rats in response to administration of corticotropin-releasing factor (CRF).	indolamine	104-116	corticotropin releasing hormone	Rattus norvegicus	172-202
8348337-1	1993	Aromatic L-amino acid decarboxylase (AADC) is involved in the biosynthesis of catecholamines and indolamines.	indolamine	97-108	dopa decarboxylase	Homo sapiens	37-41
1989631-5	1991	Trp-P-2 and other heterocyclic amines were the newly discovered naturally occurring inhibitors of the indoleamine metabolism.	indolamine	102-113	polycystin 2, transient receptor potential cation channel	Mus musculus	0-7
2124333-8	1990	These results indicate a separate neuronal storage of TRH and 5-HT in the structures (ventral part of the lumbar spinal cord, nucleus accumbens, septum) in which the peptide and indoleamine coexist in 5-HT neurons.	indolamine	178-189	thyrotropin releasing hormone	Rattus norvegicus	54-57
34229214-2	2021	This study aimed to investigate the changes in catecholamine and indolamine metabolism in response to the central action of neuropeptide Y (NPY) in different feeding statuses and the underlying mechanisms.	indolamine	65-75	neuropeptide Y	Gallus gallus	124-138
34229214-2	2021	This study aimed to investigate the changes in catecholamine and indolamine metabolism in response to the central action of neuropeptide Y (NPY) in different feeding statuses and the underlying mechanisms.	indolamine	65-75	neuropeptide Y	Gallus gallus	140-143
2476681-5	1989	The time course of the change in indoleamines suggests that administration of TRH peptides elevated the synthesis, rather than the release, of 5-HT from these nerve terminals.	indolamine	33-45	thyrotropin releasing hormone	Rattus norvegicus	78-81
2532443-5	1989	It is suggested that the LC has numerous masked indoleamine cells that contain large amounts of MAO in the cytoplasm, so that under physiological conditions, the serotoninimmunoreactivity of these cells is masked.	indolamine	48-59	monoamine oxidase A	Rattus norvegicus	96-99
6311344-0	1983	Regulation of indoleamine N-acetyltransferase activity in the retina: effects of light and dark, protein synthesis inhibitors and cyclic nucleotide analogs.	indolamine	14-25	bromodomain containing 2	Homo sapiens	26-45
2961853-5	1987	On the basis of the similarity of the actions of the 2 classes of drug studied, we hypothesize further that 5-HT1A receptors mediate an inhibitory process that serves to terminate the indoleamine-induced facilitation.	indolamine	184-195	5-hydroxytryptamine receptor 1A	Oryctolagus cuniculus	108-114
3107298-10	1987	On the other hand, the indole amine appeared to act with similar potency in stimulating PRL release both basal and TRH-induced.	indolamine	23-35	prolactin	Rattus norvegicus	88-91
3107298-10	1987	On the other hand, the indole amine appeared to act with similar potency in stimulating PRL release both basal and TRH-induced.	indolamine	23-35	thyrotropin releasing hormone	Rattus norvegicus	115-118
3146586-0	1988	Immunomodulation by indoleamines: serotonin and melatonin action on DNA and interferon-gamma synthesis by human peripheral blood mononuclear cells.	indolamine	20-32	interferon gamma	Homo sapiens	76-92
2897354-9	1988	It was concluded that the increase in brain indoleamines induced by T-2 toxin could contribute to feed refusal in animals suffering from T-2 toxicosis.	indolamine	44-56	brachyury 2	Rattus norvegicus	68-71
2901977-7	1988	Accumulation of indoleamines by certain amacrine cells also caused an increase of the ERG b-wave.	indolamine	16-28	ETS transcription factor ERG	Homo sapiens	86-89
6100312-7	1984	The regional concentrations of amine metabolites in the CSF is in part a reflection of the concentration of catecholamines and indoleamines in the immediately adjacent neuronal parenchyma.	indolamine	127-139	colony stimulating factor 2	Rattus norvegicus	56-59
6355908-1	1983	A modification of the histofluorescent technique is described which allows for the enhanced visualization of catecholamine/indoleamine (CA/IN)-containing neurons and fibers in CNS and peripheral tissues.	indolamine	123-134	calcineurin binding protein 1	Homo sapiens	136-141
6355908-1	1983	A modification of the histofluorescent technique is described which allows for the enhanced visualization of catecholamine/indoleamine (CA/IN)-containing neurons and fibers in CNS and peripheral tissues.	indolamine	123-134	calcineurin binding protein 1	Homo sapiens	119-121
7046745-0	1982	Direct inhibition of brain sepiapterin reductase by a catecholamine and an indoleamine.	indolamine	75-86	sepiapterin reductase	Homo sapiens	27-48
7047583-10	1982	The indolamine spinal cells may act as interneurons in spinal circuits, control spinal blood flow through vessel innervation, or play a role in CSF composition through central canal innervation.	indolamine	4-14	colony stimulating factor 2	Homo sapiens	144-147
7045869-7	1982	Melatonin, a pineal indolamine, caused significant stimulation of LH-RH release at a concentration as low as 10 nM.	indolamine	20-30	gonadotropin releasing hormone 1	Rattus norvegicus	66-71
311280-1	1978	Plasma immunoreactive PRL responses to indoleamines and their metabolites were studied in urethane-anesthetized rats.	indolamine	39-51	prolactin	Rattus norvegicus	22-25
311280-8	1978	These results suggest that indoleamines as well as their metabolites play a role in regulating PRL secretion in rats.	indolamine	27-39	prolactin	Rattus norvegicus	95-98
1255585-1	1976	The activity of monoamine oxidase (MAO), an enzyme which metabolized catecholamines and indoleamines, was determined in rat placenta at various stages of gestation, in human term placenta, and in choriocarcinoma grown in culture.	indolamine	88-100	monoamine oxidase A	Rattus norvegicus	16-33
258162-2	1978	It catalyses the oxidative cleavage of the pyrrole ring of various indoleamines with a much broader specificity of substrate than tryptophan 2,3-dioxygenase.	indolamine	67-79	tryptophan 2,3-dioxygenase	Mus musculus	130-156
624949-0	1978	Rat and mouse brain histamine N-methyltransferase: modulation by methylated indoleamines.	indolamine	76-88	histamine N-methyltransferase	Mus musculus	20-49
1255585-1	1976	The activity of monoamine oxidase (MAO), an enzyme which metabolized catecholamines and indoleamines, was determined in rat placenta at various stages of gestation, in human term placenta, and in choriocarcinoma grown in culture.	indolamine	88-100	monoamine oxidase A	Rattus norvegicus	35-38
31325597-6	2019	For more than two decades, our research has been focused on the mechanisms of protein kinases, CaM Kinase and Serotonin transporter mediated alterations of indolamines in TIDM.	indolamine	156-167	solute carrier family 6 member 4	Homo sapiens	110-131
1023563-0	1976	Effect of indoleamine derivates administered at birth on growth and plasma growth hormone levels in the rat.	indolamine	10-21	gonadotropin releasing hormone receptor	Rattus norvegicus	75-89
4789775-0	1973	Role of indoleamines and catecholamines in the control of gonadotrophin and growth hormone secretion.	indolamine	8-20	growth hormone 1	Homo sapiens	76-90
55662-3	1976	There is evidence that catecholamines and indolamines directly affect prolactin release.	indolamine	42-53	prolactin	Homo sapiens	70-79
1053788-0	1975	Evidence that 5-methoxy-N, N-dimethyl tryptamine is a specific substrate for MAO-A in the rat: implications for the indoleamine dependent behavioural syndrome.	indolamine	116-127	monoamine oxidase A	Rattus norvegicus	77-82
30470234-9	2018	Neopterin and IP-10 were associated with marked changes in KP metabolites in CSF with increasing kynurenine/tryptophan ratio reflecting indoleamine 2,3-dioxygenase activity.	indolamine	136-147	C-X-C motif chemokine ligand 10	Homo sapiens	14-19
30585477-1	2019	The heme enzyme indoleamine 2,3-dioxygenase-1 (IDO1) catalyzes the first reaction of l-tryptophan oxidation along the kynurenine pathway.	indolamine	16-27	indoleamine 2,3-dioxygenase 1	Homo sapiens	47-51
30261680-7	2018	Therefore, the intake of a glass of MLT-enriched red wine changed serum levels of the indoleamine, supporting the role of wine MLT in counteracting the physiological decline of the hormone into the bloodstream.	indolamine	86-97	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	36-39
29990677-3	2018	METHODS: We evaluated 101 patients with chronic hepatitis C treated with PEG-IFN-alpha2a, and 40 controls, so as to determine the activation of indolamine 2,3-dioxygenase (IDO) and tryptophan (TRP) and their metabolites" concentrations/levels: kynurenine (KYN), kynurenic acid (KYNA) and anthranilic acid (AA).	indolamine	144-154	indoleamine 2,3-dioxygenase 1	Homo sapiens	172-175
30261680-7	2018	Therefore, the intake of a glass of MLT-enriched red wine changed serum levels of the indoleamine, supporting the role of wine MLT in counteracting the physiological decline of the hormone into the bloodstream.	indolamine	86-97	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	127-130
29897749-4	2018	In addition, in hIDO1, the indoleamine group of the substrate Trp is H-bonded to S167 through a bridging water, while that in hTDO is directly H-bonded to H76.	indolamine	27-38	indoleamine 2,3-dioxygenase 1	Homo sapiens	16-21
25580584-5	2015	Genome-wide transcriptome analysis revealed CB1R-dependent, tumor-induced up-regulation of the hepatic expression of CB1R, its endogenous ligand anandamide, and a number of tumor-promoting genes, including the GRB2 interactome as well as Forkhead Box M1 and its downstream target, the tryptophan-catalyzing enzyme indoleamine 2,3-dioxygenase.	indolamine	314-325	cannabinoid receptor 1 (brain)	Mus musculus	44-48
28370493-12	2017	The efficacy of melatonin in counteracting the NLRP3 inflammasome activation further confirms the indoleamine as a useful therapeutic drug against this serious condition.	indolamine	98-109	NLR family, pyrin domain containing 3	Mus musculus	47-52
28511073-1	2017	Indoleamine and tryptophan 2,3-dioxygenases (IDO1 and TDO2) are pyrrolases catalyzing the oxidative cleavage of the 2,3-double bond of L-tryptophan in kynurenine pathway.	indolamine	0-11	indoleamine 2,3-dioxygenase 1	Homo sapiens	45-49
28511073-1	2017	Indoleamine and tryptophan 2,3-dioxygenases (IDO1 and TDO2) are pyrrolases catalyzing the oxidative cleavage of the 2,3-double bond of L-tryptophan in kynurenine pathway.	indolamine	0-11	tryptophan 2,3-dioxygenase	Homo sapiens	54-58
29520368-3	2017	Tryptophan entry into this pathway is controlled by rate-limiting indoleamine/tryptophan 2,3-dioxygenases (DOs: Ido1, Ido2, Tdo2).	indolamine	66-77	indoleamine 2,3-dioxygenase 1	Mus musculus	112-116
29520368-3	2017	Tryptophan entry into this pathway is controlled by rate-limiting indoleamine/tryptophan 2,3-dioxygenases (DOs: Ido1, Ido2, Tdo2).	indolamine	66-77	indoleamine 2,3-dioxygenase 2	Mus musculus	118-122
29520368-3	2017	Tryptophan entry into this pathway is controlled by rate-limiting indoleamine/tryptophan 2,3-dioxygenases (DOs: Ido1, Ido2, Tdo2).	indolamine	66-77	tryptophan 2,3-dioxygenase	Mus musculus	124-128
26475510-2	2016	To address this issue, we investigated the ability of these indoleamines to mitigate the behavioral phenotypes associated with NMDA-receptor (NMDAR) hypofunction in mice.	indolamine	60-72	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	127-140
26475510-2	2016	To address this issue, we investigated the ability of these indoleamines to mitigate the behavioral phenotypes associated with NMDA-receptor (NMDAR) hypofunction in mice.	indolamine	60-72	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	142-147
26475510-4	2016	The MLT/NAS-mediated protection of the phenotype in FST could be correlated to the ability of these indoleamines to counteract the deleterious effects of chronic ketamine on pro-survival molecular events by restoring the activities in MEK-ERK and PI3K-AKT pathways in the hippocampus.	indolamine	100-112	midkine	Mus musculus	235-238
26475510-4	2016	The MLT/NAS-mediated protection of the phenotype in FST could be correlated to the ability of these indoleamines to counteract the deleterious effects of chronic ketamine on pro-survival molecular events by restoring the activities in MEK-ERK and PI3K-AKT pathways in the hippocampus.	indolamine	100-112	mitogen-activated protein kinase 1	Mus musculus	239-242
29531094-2	2018	One mechanism by which this is accomplished is through immune suppression effected by up-regulation of indoleamine 2,3-dioxygenase (IDO1), a heme enzyme that catalyzes the oxidation of tryptophan to N-formylkynurenine.	indolamine	103-114	indoleamine 2,3-dioxygenase 1	Homo sapiens	132-136
29343435-4	2018	This FAO shift increased the protoporphyrin IX prosthetic group of indoleamine 2,3-dioxgenase-1 (IDO) while suppressing interleukin(IL)-6 and IL-12 cytokine expression, culminating in enhanced IDO activity and the generation of regulatory T cells.	indolamine	67-78	indoleamine 2,3-dioxygenase 1	Homo sapiens	97-100
28912098-2	2017	Melatonin, an indolamine synthesized in the pineal gland, was previously shown to protect against sodium fluoride (NaF)-induced hepatotoxicity.	indolamine	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	115-118
25580584-5	2015	Genome-wide transcriptome analysis revealed CB1R-dependent, tumor-induced up-regulation of the hepatic expression of CB1R, its endogenous ligand anandamide, and a number of tumor-promoting genes, including the GRB2 interactome as well as Forkhead Box M1 and its downstream target, the tryptophan-catalyzing enzyme indoleamine 2,3-dioxygenase.	indolamine	314-325	cannabinoid receptor 1 (brain)	Mus musculus	117-121
25580584-5	2015	Genome-wide transcriptome analysis revealed CB1R-dependent, tumor-induced up-regulation of the hepatic expression of CB1R, its endogenous ligand anandamide, and a number of tumor-promoting genes, including the GRB2 interactome as well as Forkhead Box M1 and its downstream target, the tryptophan-catalyzing enzyme indoleamine 2,3-dioxygenase.	indolamine	314-325	growth factor receptor bound protein 2	Mus musculus	210-214
25534866-1	2015	BACKGROUND AND AIM: Tryptophan (Trp) degradation via indoleamine (2,3)-dioxygenase (IDO), with consequent increased in kynurenine (Kyn) concentrations, has been proposed as marker of immune system activation.	indolamine	53-64	indoleamine 2,3-dioxygenase 1	Homo sapiens	84-87