PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26466678-6	2015	Deletion of KES1 suppresses plasma membrane-missorting defects and the accumulation of intracellular ergosterol in drs2 mutants.	Ergosterol	101-111	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	12-16
26466678-6	2015	Deletion of KES1 suppresses plasma membrane-missorting defects and the accumulation of intracellular ergosterol in drs2 mutants.	Ergosterol	101-111	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	115-119
25988614-7	2015	Vitamin D and lumisterol, produced in the skin after exposure to UVB, are also metabolized by CYP11A1 to several hydroxyderivatives.	Ergosterol	14-24	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	94-101
26466337-6	2015	The aim of this work was to characterize the X. dendrorhous CBR encoding gene and to study its involvement in P450 reactions in ergosterol and carotenoid biosynthesis.	Ergosterol	128-138	cytochrome-b5 reductase	Saccharomyces cerevisiae S288C	60-63
26466337-9	2015	The crtR- mutant strain produced a lower proportion of ergosterol than did the parental strain.	Ergosterol	55-65	solute carrier family 6 member 8	Homo sapiens	4-8
26466337-10	2015	These results indicate that even though one of the two CBR genes could be involved in ergosterol biosynthesis, crtR complements their absence in the cbr- mutant strains, at least for ergosterol production.	Ergosterol	86-96	cytochrome-b5 reductase	Saccharomyces cerevisiae S288C	55-58
26466337-10	2015	These results indicate that even though one of the two CBR genes could be involved in ergosterol biosynthesis, crtR complements their absence in the cbr- mutant strains, at least for ergosterol production.	Ergosterol	183-193	solute carrier family 6 member 8	Homo sapiens	111-115
26466337-10	2015	These results indicate that even though one of the two CBR genes could be involved in ergosterol biosynthesis, crtR complements their absence in the cbr- mutant strains, at least for ergosterol production.	Ergosterol	183-193	cytochrome-b5 reductase	Saccharomyces cerevisiae S288C	149-152
26466337-11	2015	The higher NADH-dependent cytochrome c reductase activity together with the higher transcript levels of CBR.1 and CYB5 in the crtR- mutant as well as the lower NADH-dependent activity in CBS-cbr.1- strongly suggest that CBR.1-CYB5 via participates as an alternative electron donor pathway for P450 enzymes involved in ergosterol biosynthesis in X. dendrorhous.	Ergosterol	318-328	carbonyl reductase 1	Homo sapiens	191-194
25448732-3	2015	Studies, initially with purified enzyme, reveal that 7-dehydrocholesterol (7DHC), ergosterol, lumisterol 3, and vitamins D3 and D2 also serve as substrates for CYP11A1, with 7DHC being better and vitamins D3 and D2 being poorer substrates than cholesterol.	Ergosterol	82-92	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	160-167
25957702-8	2015	Er-Lips of ergosterol/phospholipids ratios of 1:4 or 1:6 exerts more pronounced protective ability of insulin in simulated gastrointestinal fluids and hypoglycemic effects in rats than other formulations.	Ergosterol	11-21	insulin	Homo sapiens	102-109
25957702-11	2015	It was concluded that ergosterol could be used as a substitute for cholesterol and bile salt derivatives in liposomes to enhance oral bioavailability of insulin.	Ergosterol	22-32	insulin	Homo sapiens	153-160
26098777-8	2015	We found that ergosterol-mediated suppression of breast cancer cell viability occurred through apoptosis and that ergosterol up-regulated expression of the tumor suppressor Foxo3.	Ergosterol	114-124	forkhead box O3	Homo sapiens	173-178
26456460-2	2015	Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (Saccharomyces cerevisiae--Erg26p, Homo sapiens--NSDHL (NAD(P) dependent steroid dehydrogenase-like)), an essential enzyme in the ergosterol/cholesterol biosynthesis pathway.	Ergosterol	225-235	NAD(P) dependent steroid dehydrogenase-like	Homo sapiens	144-149
26418026-1	2015	We investigated the impact of the deletions of genes from the final steps in the biosynthesis of ergosterol (ERG6, ERG2, ERG3, ERG5, ERG4) on the physiological function of the Saccharomyces cerevisiae plasma membrane by a combination of biological tests and the diS-C3(3) fluorescence assay.	Ergosterol	97-107	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	109-113
26418026-1	2015	We investigated the impact of the deletions of genes from the final steps in the biosynthesis of ergosterol (ERG6, ERG2, ERG3, ERG5, ERG4) on the physiological function of the Saccharomyces cerevisiae plasma membrane by a combination of biological tests and the diS-C3(3) fluorescence assay.	Ergosterol	97-107	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	115-119
26418026-1	2015	We investigated the impact of the deletions of genes from the final steps in the biosynthesis of ergosterol (ERG6, ERG2, ERG3, ERG5, ERG4) on the physiological function of the Saccharomyces cerevisiae plasma membrane by a combination of biological tests and the diS-C3(3) fluorescence assay.	Ergosterol	97-107	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	121-125
26418026-1	2015	We investigated the impact of the deletions of genes from the final steps in the biosynthesis of ergosterol (ERG6, ERG2, ERG3, ERG5, ERG4) on the physiological function of the Saccharomyces cerevisiae plasma membrane by a combination of biological tests and the diS-C3(3) fluorescence assay.	Ergosterol	97-107	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	127-131
26418026-1	2015	We investigated the impact of the deletions of genes from the final steps in the biosynthesis of ergosterol (ERG6, ERG2, ERG3, ERG5, ERG4) on the physiological function of the Saccharomyces cerevisiae plasma membrane by a combination of biological tests and the diS-C3(3) fluorescence assay.	Ergosterol	97-107	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	133-137
26098102-2	2015	In this study, 7-dehydrocholesterol (7-DHC, a crucial precursor of vitamin D3) biosynthesis pathway was constructed in Saccharomyces cerevisiae BY4742 with endogenous ergosterol synthesis pathway blocked by knocking out the erg5 gene (encoding C-22 desaturase).	Ergosterol	167-177	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	224-228
25889168-3	2015	In the present study, we explored dynamic control of ERG9 expression using different ergosterol-responsive promoters to improve the production of non-native isoprenoids.	Ergosterol	85-95	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	53-57
25725023-8	2015	Also, genes involved in ergosterol biosynthesis (NSG2) cause improvement of growth at 10 C, dependent on tryptophan uptake, while the gluconeogenesis gene PCK1 and the proline biosynthesis gene PRO2 cause an improvement in growth at 10 C, independent of tryptophan and phosphate uptake.	Ergosterol	24-34	Nsg2p	Saccharomyces cerevisiae S288C	49-53
25725023-8	2015	Also, genes involved in ergosterol biosynthesis (NSG2) cause improvement of growth at 10 C, dependent on tryptophan uptake, while the gluconeogenesis gene PCK1 and the proline biosynthesis gene PRO2 cause an improvement in growth at 10 C, independent of tryptophan and phosphate uptake.	Ergosterol	24-34	phosphoenolpyruvate carboxykinase PCK1	Saccharomyces cerevisiae S288C	155-159
26082652-2	2015	It inhibits fungal lanosterol 14alpha-demethylase in the ergosterol biosynthesis pathway, has potent antifungal activity against dermatophytes, as well as activity against Candida spp.	Ergosterol	57-67	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	19-49
25906980-0	2015	Identification and functional characterization of the CYP51 gene from the yeast Xanthophyllomyces dendrorhous that is involved in ergosterol biosynthesis.	Ergosterol	130-140	sterol 14-demethylase	Saccharomyces cerevisiae S288C	54-59
25906980-3	2015	Among these enzymes, the CYP51 family, which is involved in ergosterol biosynthesis, is one of the most remarkable that has C14-demethylase activity.	Ergosterol	60-70	sterol 14-demethylase	Saccharomyces cerevisiae S288C	25-30
25906980-8	2015	Additionally, the CYP51 gene mutation in X. dendrorhous increased HMGR (hydroxy-methylglutaryl-CoA reductase, involved in the mevalonate pathway) and crtR (cytochrome P450 reductase) transcript levels, which could be associated with reduced ergosterol production.	Ergosterol	241-251	sterol 14-demethylase	Saccharomyces cerevisiae S288C	18-23
25906980-9	2015	CONCLUSIONS: These results suggest that the CYP51 gene identified in X. dendrorhous encodes a functional sterol C14-demethylase that is involved in ergosterol biosynthesis.	Ergosterol	148-158	sterol 14-demethylase	Saccharomyces cerevisiae S288C	44-49
25830359-5	2015	Introduction of BbSQE-I or -II into Saccharomyces cerevisie erg1 mutants resulted in the complementation of ergosterol auxotrophy.	Ergosterol	108-118	squalene monooxygenase	Saccharomyces cerevisiae S288C	60-64
25889168-5	2015	We found mRNA levels for ERG11, ERG2 and ERG3 expression were significantly lower in the engineered strain over the reference strain BY4742, indicating these genes are transcriptionally down-regulated when ergosterol is in excess.	Ergosterol	206-216	sterol 14-demethylase	Saccharomyces cerevisiae S288C	25-30
25889168-5	2015	We found mRNA levels for ERG11, ERG2 and ERG3 expression were significantly lower in the engineered strain over the reference strain BY4742, indicating these genes are transcriptionally down-regulated when ergosterol is in excess.	Ergosterol	206-216	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	32-36
25889168-5	2015	We found mRNA levels for ERG11, ERG2 and ERG3 expression were significantly lower in the engineered strain over the reference strain BY4742, indicating these genes are transcriptionally down-regulated when ergosterol is in excess.	Ergosterol	206-216	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	41-45
25889168-6	2015	Further replacement of the native ERG9 promoter with these ergosterol-responsive promoters revealed that all engineered strains improved amorpha-4,11-diene by 2~5-fold over the reference strain with ERG9 under its native promoter.	Ergosterol	59-69	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	199-203
25655993-5	2015	Ergosterol binding represses its transcription activity, while dissociation of the ligand leads to relocalization of Upc2 from cytosol to nucleus for transcriptional activation.	Ergosterol	0-10	Upc2p	Saccharomyces cerevisiae S288C	117-121
25418299-7	2014	However, these binding sites are specific for both cholesterol and beta2AR, as shown with control experiments using ergosterol and a control membrane protein (KpOmpA).	Ergosterol	116-126	adrenoceptor beta 2	Homo sapiens	67-74
25475753-8	2015	Genetic manipulation further demonstrated that the altered expression activity of some genes (such as ERG1, ERG9, and ERG11) involved in ergosterol synthesis partly explained the trait improvement in ZG27.	Ergosterol	137-147	squalene monooxygenase	Saccharomyces cerevisiae S288C	102-106
25475753-8	2015	Genetic manipulation further demonstrated that the altered expression activity of some genes (such as ERG1, ERG9, and ERG11) involved in ergosterol synthesis partly explained the trait improvement in ZG27.	Ergosterol	137-147	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	108-112
25475753-8	2015	Genetic manipulation further demonstrated that the altered expression activity of some genes (such as ERG1, ERG9, and ERG11) involved in ergosterol synthesis partly explained the trait improvement in ZG27.	Ergosterol	137-147	sterol 14-demethylase	Saccharomyces cerevisiae S288C	118-123
25130438-0	2014	Lumisterol is metabolized by CYP11A1: discovery of a new pathway.	Ergosterol	0-10	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	29-36
25512882-2	2014	Amino acid substitutions (single or multiple) are frequent on ERG11, a membrane bound enzyme of Ergosterol biosynthesis pathway.	Ergosterol	96-106	sterol 14-demethylase	Saccharomyces cerevisiae S288C	62-67
23777559-6	2013	Sterols, however, showed a species-specific binding pattern: cholesterol did not show strong binding to human ApoD, whereas NLaz and Laz did bind ergosterol.	Ergosterol	146-156	Neural Lazarillo	Drosophila melanogaster	124-128
24867980-2	2014	Upc2 and Ecm22 in Saccharomyces cerevisiae and Upc2 in Candida albicans are the transcriptional regulators of ERG11, the gene encoding the target of azoles in the ergosterol biosynthesis pathway.	Ergosterol	163-173	Upc2p	Saccharomyces cerevisiae S288C	0-4
24867980-2	2014	Upc2 and Ecm22 in Saccharomyces cerevisiae and Upc2 in Candida albicans are the transcriptional regulators of ERG11, the gene encoding the target of azoles in the ergosterol biosynthesis pathway.	Ergosterol	163-173	Ecm22p	Saccharomyces cerevisiae S288C	9-14
24867980-2	2014	Upc2 and Ecm22 in Saccharomyces cerevisiae and Upc2 in Candida albicans are the transcriptional regulators of ERG11, the gene encoding the target of azoles in the ergosterol biosynthesis pathway.	Ergosterol	163-173	Upc2p	Saccharomyces cerevisiae S288C	47-51
24992193-7	2014	Annexin V-FITC/PI staining, nuclear Hoechst 33342 staining and DNA fragmentation analysis revealed that FPKc and ES could induce SW-480 cells apoptosis.	Ergosterol	113-115	annexin A5	Homo sapiens	0-9
24361577-5	2014	Tryptophan fluorescence titration reveals that NLaz(L130R) loses its ability to bind ergosterol and the pheromone 7(z)-tricosene but retains retinoic acid binding.	Ergosterol	85-95	Neural Lazarillo	Drosophila melanogaster	47-51
25386220-7	2014	Ergosterol, the active compound in CMCS that was detected by HPLC, played a dose-dependent inhibition role on activated HSCs via upregulating expressions of permeability of the lysosomal membrane and downregulating levels of EdU, F-actin, and alpha-SMA on activated HSCs in vitro.	Ergosterol	0-10	actin alpha 2, smooth muscle, aorta	Mus musculus	243-252
24164706-5	2014	We show that Csn5 is involved in modulation of the genes controlling amino acid and lipid metabolism and especially ergosterol biosynthesis.	Ergosterol	116-126	COP9 signalosome catalytic subunit RRI1	Saccharomyces cerevisiae S288C	13-17
24164706-6	2014	These alterations in gene expression correlate with the lower ergosterol levels and increased intracellular zinc content which we observed in csn5 null mutant cells.	Ergosterol	62-72	COP9 signalosome catalytic subunit RRI1	Saccharomyces cerevisiae S288C	142-146
24818477-4	2014	In addition, we knocked out C-24 methyl transferase (Erg6p) and C-22 dehydrogenase (Erg5p) to inhibit the conversion of zymosterol to ergosterol.	Ergosterol	134-144	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	53-58
24818477-4	2014	In addition, we knocked out C-24 methyl transferase (Erg6p) and C-22 dehydrogenase (Erg5p) to inhibit the conversion of zymosterol to ergosterol.	Ergosterol	134-144	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	84-89
23781023-5	2013	Lipid analysis demonstrates that elevated levels of Mcp1 and Mcp2 restore the alterations in mitochondrial phospholipid and ergosterol homeostasis in cells lacking Mdm10.	Ergosterol	124-134	Mcp1p	Saccharomyces cerevisiae S288C	52-56
23781023-5	2013	Lipid analysis demonstrates that elevated levels of Mcp1 and Mcp2 restore the alterations in mitochondrial phospholipid and ergosterol homeostasis in cells lacking Mdm10.	Ergosterol	124-134	Cqd2p	Saccharomyces cerevisiae S288C	61-65
23781023-6	2013	Collectively, this work identifies two novel proteins that play a role in mitochondrial lipid homeostasis and describes a role of Mdm10 in ergosterol trafficking.	Ergosterol	139-149	Mdm10p	Saccharomyces cerevisiae S288C	130-135
25105295-6	2014	Interestingly, HSF1 mutant was not only highly susceptible to BER but also displayed collateral susceptibility towards drugs targeting cell wall (CW) and ergosterol biosynthesis.	Ergosterol	154-164	heat shock transcription factor 1	Homo sapiens	15-19
24632026-1	2014	Most sterols, such as cholesterol and ergosterol, become functional only after the removal of the two methyl groups at C-4 from their biosynthetic precursors.	Ergosterol	38-48	complement C4A (Rodgers blood group)	Homo sapiens	119-122
24855835-0	2014	Ergosterol reverses multidrug resistance in SGC7901/Adr cells.	Ergosterol	0-10	sarcoglycan beta	Homo sapiens	44-47
25151749-1	2014	Lanosterol synthase is encoded by the erg7 gene and catalyzes the cyclization of 2, 3-oxidosqualene, which is a rate-limiting step of the inherent mevalonate (MVA)/ergosterol metabolic pathway in Saccharomyces cerevisiae.	Ergosterol	164-174	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	38-42
24598749-1	2014	Farnesyl diphosphate synthase (FPPS) is an essential enzyme involved in the biosynthesis of sterols (cholesterol in humans and ergosterol in yeasts, fungi and trypanosomatid parasites) as well as in protein prenylation.	Ergosterol	127-137	farnesyl diphosphate synthase	Homo sapiens	0-29
24598749-1	2014	Farnesyl diphosphate synthase (FPPS) is an essential enzyme involved in the biosynthesis of sterols (cholesterol in humans and ergosterol in yeasts, fungi and trypanosomatid parasites) as well as in protein prenylation.	Ergosterol	127-137	farnesyl diphosphate synthase	Homo sapiens	31-35
24163365-5	2013	We now show that it is two novel anaerobic AR1b elements in the UPC2 promoter that direct global ERG gene expression in response to a block in de novo ergosterol biosynthesis, brought about by antifungal drug treatment.	Ergosterol	151-161	Upc2p	Saccharomyces cerevisiae S288C	64-68
24044691-2	2013	The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-chalcone, ellagic acid, luteolin, galangin, and genistein) against the dermatophyte Trichophyton rubrum and their effects on fatty acid and ergosterol synthesis.	Ergosterol	291-301	fatty acid synthase	Homo sapiens	118-121
23638723-1	2013	Sterol 14alpha-demethylase (CYP51) is a cytochrome P450 heme thiolate containing enzyme involved in biosynthesis of membrane sterols, including sterol in animals, ergosterol in fungi, and a variety of C24-modified sterols in plants and protozoa.	Ergosterol	163-173	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	0-26
23638723-1	2013	Sterol 14alpha-demethylase (CYP51) is a cytochrome P450 heme thiolate containing enzyme involved in biosynthesis of membrane sterols, including sterol in animals, ergosterol in fungi, and a variety of C24-modified sterols in plants and protozoa.	Ergosterol	163-173	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	28-33
23606207-0	2013	The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals.	Ergosterol	63-73	phosphatidylinositol transporter	Saccharomyces cerevisiae S288C	35-41
23548573-6	2013	Endogenous ergosterol was likely converted into vitamin D2 by UV irradiation and thermal isomerization, and then the resulting vitamin D2 was converted to 25-hydroxyvitamin D2 by CYP2R1.	Ergosterol	11-21	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	179-185
23593013-3	2013	Targeting the molecular chaperone Hsp90 or its downstream effector, the protein phosphatase calcineurin, abrogates resistance to the most widely deployed antifungals, the azoles, which inhibit ergosterol biosynthesis.	Ergosterol	193-203	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	34-39
23053114-5	2013	Our results demonstrated that Ste2p could transduce a signal even in the cholesterol-rich membrane, but the maximum signal intensity was weaker than that transduced in the ergosterol-rich original (WT) membrane.	Ergosterol	172-182	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	30-35
23593013-8	2013	Whole-genome sequencing identified mutations in a gene encoding a transcriptional activator of drug efflux pumps, PDR1, and a gene encoding a transcriptional repressor of ergosterol biosynthesis genes, MOT3, that transformed azole resistance of two lineages from dependent on calcineurin to independent of this regulator.	Ergosterol	171-181	Mot3p	Saccharomyces cerevisiae S288C	202-206
23382196-0	2013	H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A.	Ergosterol	58-68	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	23-27
23382196-4	2013	To determine the role of Set1 in BFA resistance, we discovered that Set1 is important for the expression of genes in the ergosterol biosynthetic pathway, including the rate-limiting enzyme HMG-CoA reductase.	Ergosterol	121-131	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	25-29
23382196-4	2013	To determine the role of Set1 in BFA resistance, we discovered that Set1 is important for the expression of genes in the ergosterol biosynthetic pathway, including the rate-limiting enzyme HMG-CoA reductase.	Ergosterol	121-131	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	68-72
23382196-5	2013	Consequently, deletion of SET1 leads to a reduction in HMG-CoA reductase protein and total cellular ergosterol.	Ergosterol	100-110	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	26-30
23382196-6	2013	In addition, the lack of Set1 results in an increase in the expression of DAN1 and PDR11, two genes involved in ergosterol uptake.	Ergosterol	112-122	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	25-29
22918956-7	2012	We found that ER membranes in spf1 cells become similar in their ergosterol content to mitochondrial membranes.	Ergosterol	65-75	ion-transporting P-type ATPase SPF1	Saccharomyces cerevisiae S288C	30-34
23022663-0	2013	Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway.	Ergosterol	158-168	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	86-90
23022663-0	2013	Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway.	Ergosterol	158-168	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	138-143
23022663-5	2013	This strain which was crossed to a wildtype and daughter segregants showed an accumulation of squalene epoxides as well as ergosterol indicating that the mutation entailed a leaky block at ERG7.	Ergosterol	123-133	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	189-193
23022663-10	2013	Both FGerg27 and erg27 strains containing this fusion plasmid and the mouse ERG27 orthologue showed restoration of ergosterol biosynthesis with minimal accumulation of squalene epoxides.	Ergosterol	115-125	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	7-12
23022663-10	2013	Both FGerg27 and erg27 strains containing this fusion plasmid and the mouse ERG27 orthologue showed restoration of ergosterol biosynthesis with minimal accumulation of squalene epoxides.	Ergosterol	115-125	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	76-81
23022663-11	2013	These results indicate retention of Erg7p in the ER increases its activity and suggest a novel method of regulation of ergosterol biosynthesis.	Ergosterol	119-129	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	36-41
24494038-1	2013	Novel metabolic pathways initiated by the enzymatic action of CYP11A1 on 7DHC (7-dehydrocholesterol), ergosterol, vitamins D3 and D2 were characterized with help of chemical synthesis, UV and mass spectrometry and NMR analyses.	Ergosterol	102-112	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	62-69
22733490-0	2012	Interaction of ergosterol with bovine serum albumin and human serum albumin by spectroscopic analysis.	Ergosterol	15-25	albumin	Homo sapiens	38-51
22733490-0	2012	Interaction of ergosterol with bovine serum albumin and human serum albumin by spectroscopic analysis.	Ergosterol	15-25	albumin	Homo sapiens	62-75
22733490-1	2012	This study was designed to examine the interactions of ergosterol with bovine serum albumin (BSA) and human serum albumin (HSA) under physiological conditions with the drug concentrations in the range of 2.99-105.88 muM and the concentration of proteins was fixed at 5.0 muM.	Ergosterol	55-65	albumin	Homo sapiens	78-97
22733490-1	2012	This study was designed to examine the interactions of ergosterol with bovine serum albumin (BSA) and human serum albumin (HSA) under physiological conditions with the drug concentrations in the range of 2.99-105.88 muM and the concentration of proteins was fixed at 5.0 muM.	Ergosterol	55-65	albumin	Homo sapiens	78-91
22733490-2	2012	The analysis of emission spectra quenching at different temperatures revealed that the quenching mechanism of HSA/BSA by ergosterol was the static quenching.	Ergosterol	121-131	albumin	Homo sapiens	114-117
22733490-4	2012	The distance r between ergosterol and HSA/BSA was evaluated according to Foster non-radioactive energy transfer theory.	Ergosterol	23-33	albumin	Homo sapiens	42-45
22733490-5	2012	The results of synchronous fluorescence, 3D fluorescence, FT-IR, CD and UV-Vis absorption spectra showed that the conformations of HSA/BSA altered in the presence of ergosterol.	Ergosterol	166-176	albumin	Homo sapiens	135-138
22733490-7	2012	Besides, with the aid of three site markers (for example, phenylbutazone, ibuprofen and digitoxin), we have reported that ergosterol primarily binds to the tryptophan residues of BSA/HSA within site I (subdomain II A).	Ergosterol	122-132	albumin	Homo sapiens	179-182
23385756-1	2013	Upc2, a zinc-cluster transcription factor, is a regulator of ergosterol biosynthesis in yeast.	Ergosterol	61-71	Upc2p	Saccharomyces cerevisiae S288C	0-4
22614263-6	2012	In testate amoebae, rain exclusion decreased the density of live cells by 91 % and caused a shift in species composition at each of the altitudes studied, with ergosterol concentrations, microbial biomass, and water content explaining 25 % of the variation in species data.	Ergosterol	160-170	Ras interacting protein 1	Homo sapiens	20-24
22904057-7	2012	The RAS2(Tyr112) mutation also improved the specific galactose uptake rate and also resulted in many transcriptional changes, including ergosterol metabolism.	Ergosterol	136-146	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	4-8
22918956-8	2012	Indeed, when we visualized MOM TA protein distribution in yeast strains with reduced ergosterol content, they phenocopied the loss of Spf1.	Ergosterol	85-95	ion-transporting P-type ATPase SPF1	Saccharomyces cerevisiae S288C	134-138
22615281-0	2012	Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.	Ergosterol	32-42	sterol 14-demethylase	Saccharomyces cerevisiae S288C	123-128
22922478-0	2012	Inhibition of human neutrophil elastase by ergosterol derivatives from the mycelium of Phellinus linteus.	Ergosterol	43-53	elastase, neutrophil expressed	Homo sapiens	20-39
22615281-4	2012	In heterologous expression studies using a doxycycline-regulatable Saccharomyces cerevisiae erg11 strain, wild-type C. glabrata Erg11p fully complemented the function of S. cerevisiae sterol 14alpha-demethylase, restoring growth and ergosterol synthesis in recombinant yeast; mutated CG156 Erg11p did not.	Ergosterol	233-243	sterol 14-demethylase	Saccharomyces cerevisiae S288C	128-134
22357954-9	2012	Actin mobilization was also inhibited by ligating ergosterol and PtdIns(3)P, whereas the ligation or modification of PtdIns(4,5)P(2) augmented the vertex enrichment of actin.	Ergosterol	50-60	actin	Saccharomyces cerevisiae S288C	0-5
22622083-4	2012	This screen revealed that Osh6, a member of the oxysterol-binding protein family, can complement the vacuole fusion defect of nyv1Delta, but not erg6Delta or vac8Delta, suggesting that Osh6"s function in vacuole fusion is partly dependent on membrane ergosterol and Vac8.	Ergosterol	251-261	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	26-30
22622083-4	2012	This screen revealed that Osh6, a member of the oxysterol-binding protein family, can complement the vacuole fusion defect of nyv1Delta, but not erg6Delta or vac8Delta, suggesting that Osh6"s function in vacuole fusion is partly dependent on membrane ergosterol and Vac8.	Ergosterol	251-261	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	185-189
22622083-4	2012	This screen revealed that Osh6, a member of the oxysterol-binding protein family, can complement the vacuole fusion defect of nyv1Delta, but not erg6Delta or vac8Delta, suggesting that Osh6"s function in vacuole fusion is partly dependent on membrane ergosterol and Vac8.	Ergosterol	251-261	protein anchor VAC8	Saccharomyces cerevisiae S288C	266-270
22252807-1	2012	The inactivation of ERG3, a gene encoding sterol Delta5,6-desaturase (essential for ergosterol biosynthesis), is a known mechanism of in vitro resistance to azole antifungal drugs in the human pathogen Candida albicans.	Ergosterol	84-94	sterol-C5-desaturase	Homo sapiens	20-24
22252807-5	2012	The reversion of the double base deletion in the mutant allele (erg3-1) restored ergosterol biosynthesis and full fluconazole susceptibility in VSY2, confirming that ERG3 inactivation was the mechanism of azole resistance.	Ergosterol	81-91	C-5 sterol desaturase	Candida albicans SC5314	64-68
22252807-6	2012	Additionally, the replacement of both ERG3 alleles by erg3-1 in the wild-type strain SC5314 led to the absence of ergosterol and to fluconazole resistance without affecting filamentation.	Ergosterol	114-124	C-5 sterol desaturase	Candida albicans SC5314	38-42
22252807-6	2012	Additionally, the replacement of both ERG3 alleles by erg3-1 in the wild-type strain SC5314 led to the absence of ergosterol and to fluconazole resistance without affecting filamentation.	Ergosterol	114-124	C-5 sterol desaturase	Candida albicans SC5314	54-58
22839110-3	2012	RESULTS: A yeast multidrug resistance ABC transporter encoded by the PDR18 gene, proposed to play a role in the incorporation of ergosterol in the yeast plasma membrane, was found to confer resistance to growth inhibitory concentrations of ethanol.	Ergosterol	129-139	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	69-74
22361350-1	2012	Propiconazole is a mouse hepatotumorigenic fungicide designed to inhibit CYP51, a key enzyme in the biosynthesis of ergosterol in fungi and is widely used in agriculture to prevent fungal growth.	Ergosterol	116-126	cytochrome P450, family 51	Mus musculus	73-78
22911836-4	2012	Our metabolite analysis revealed that Cir1 influences the glycolytic pathway, ergosterol biosynthesis and inositol metabolism, which require numerous iron-dependent enzymes and play important roles in pathogenesis and antifungal sensitivity of the fungus.	Ergosterol	78-88	corepressor interacting with RBPJ, CIR1	Homo sapiens	38-42
22106170-3	2012	P450scc incorporated into the bilayer of phospholipid vesicles converted ergosterol to two major and four minor products with a k(cat) of 53 mol   min(-1)   mol P450scc(-1) and a K(m) of 0.18 mol ergosterol/mol phospholipid, similar to the values observed for cholesterol metabolism.	Ergosterol	73-83	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	0-7
22106170-3	2012	P450scc incorporated into the bilayer of phospholipid vesicles converted ergosterol to two major and four minor products with a k(cat) of 53 mol   min(-1)   mol P450scc(-1) and a K(m) of 0.18 mol ergosterol/mol phospholipid, similar to the values observed for cholesterol metabolism.	Ergosterol	73-83	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	161-168
22106170-3	2012	P450scc incorporated into the bilayer of phospholipid vesicles converted ergosterol to two major and four minor products with a k(cat) of 53 mol   min(-1)   mol P450scc(-1) and a K(m) of 0.18 mol ergosterol/mol phospholipid, similar to the values observed for cholesterol metabolism.	Ergosterol	196-206	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	0-7
22106170-4	2012	The reaction of ergosterol with P450scc was scaled up to make enough of the two major products for structural analysis.	Ergosterol	16-26	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	32-39
22106170-8	2012	Molecular modeling of ergosterol into the P450scc crystal structure positioned the ergosterol side chain consistent with formation of the above products.	Ergosterol	22-32	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	42-49
22106170-8	2012	Molecular modeling of ergosterol into the P450scc crystal structure positioned the ergosterol side chain consistent with formation of the above products.	Ergosterol	83-93	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	42-49
22106170-9	2012	Thus, we have shown that P450scc efficiently catalyzes epoxide formation with ergosterol giving rise to novel epoxy, hydroxy, and keto derivatives, without causing cleavage of the side chain.	Ergosterol	78-88	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	25-32
22197503-3	2012	Removal of ergosterol by mbetaCD incubation led to disorganization of ergosterol-enriched microdomains containing Pma1p and the 30kDa protein, resulting in displacement of these proteins from detergent-insoluble to -soluble fractions in sucrose density gradient ultracentrifugation.	Ergosterol	11-21	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	114-119
22197503-3	2012	Removal of ergosterol by mbetaCD incubation led to disorganization of ergosterol-enriched microdomains containing Pma1p and the 30kDa protein, resulting in displacement of these proteins from detergent-insoluble to -soluble fractions in sucrose density gradient ultracentrifugation.	Ergosterol	70-80	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	114-119
22106170-0	2012	Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.	Ergosterol	68-78	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	6-24
22106170-0	2012	Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.	Ergosterol	68-78	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	26-33
22106170-2	2012	The aim of this study was to test the ability of human P450scc to metabolize ergosterol, the vitamin D(2) precursor, and define the structure of the major products.	Ergosterol	77-87	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	55-62
22050222-3	2011	Squalene monooxygenase downregulation in vertebrates and fungi decreases synthesis of cholesterol and ergosterol, respectively, which makes squalene monooxygenase a potent and attractive target of hypercholesterolemia and antifungal therapies.	Ergosterol	102-112	squalene epoxidase	Homo sapiens	0-22
22359558-3	2012	The significance of H(+)-ATPase oligomerization for the activation of H(+)-ATPase by glucose was shown using the strains lcb1-100 and erg6, with the disturbed synthesis of sphyngolipid and ergosterol, respectively.	Ergosterol	189-199	serine C-palmitoyltransferase LCB1	Saccharomyces cerevisiae S288C	121-125
22050222-3	2011	Squalene monooxygenase downregulation in vertebrates and fungi decreases synthesis of cholesterol and ergosterol, respectively, which makes squalene monooxygenase a potent and attractive target of hypercholesterolemia and antifungal therapies.	Ergosterol	102-112	squalene epoxidase	Homo sapiens	140-162
21360751-0	2011	Low ergosterol content in yeast adh1 mutant enhances chitin maldistribution and sensitivity to paraquat-induced oxidative stress.	Ergosterol	4-14	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	32-36
21467572-4	2011	Our results have led to a model in which heme and ergosterol depletion alters membrane fluidity, thereby activating Hog1 for hypoxic induction.	Ergosterol	50-60	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	116-120
22384326-6	2011	ERG6 encodes a key step in ergosterol biosynthesis.	Ergosterol	27-37	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	0-4
21445244-6	2011	Subsequently, Erg8, Erg9 and HFA1 were correlated with the increased levels of ergosterol and fatty acids in CEN.PK 113-7D and single, double, and triple gene over-expression strains were constructed.	Ergosterol	79-89	phosphomevalonate kinase	Saccharomyces cerevisiae S288C	14-18
21445244-6	2011	Subsequently, Erg8, Erg9 and HFA1 were correlated with the increased levels of ergosterol and fatty acids in CEN.PK 113-7D and single, double, and triple gene over-expression strains were constructed.	Ergosterol	79-89	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	20-24
21445244-6	2011	Subsequently, Erg8, Erg9 and HFA1 were correlated with the increased levels of ergosterol and fatty acids in CEN.PK 113-7D and single, double, and triple gene over-expression strains were constructed.	Ergosterol	79-89	acetyl-CoA carboxylase HFA1	Saccharomyces cerevisiae S288C	29-33
20673806-10	2011	Genes involved in ergosterol biosynthesis, iron uptake, cell wall organization and capsule biosynthesis, in addition to NCR-sensitive genes, are Gat1-regulated in C. neoformans.	Ergosterol	18-28	solute carrier family 6 member 1	Homo sapiens	145-149
20959444-0	2010	Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast.	Ergosterol	0-10	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	21-62
21299653-0	2011	Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors.	Ergosterol	14-24	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	96-100
21299653-0	2011	Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors.	Ergosterol	14-24	Mot3p	Saccharomyces cerevisiae S288C	120-124
21299653-0	2011	Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors.	Ergosterol	14-24	Rox1p	Saccharomyces cerevisiae S288C	129-133
21299653-2	2011	Here we characterize a novel physiological determinant of osmostress tolerance, which involves the Hog1-dependent transcriptional downregulation of ergosterol biosynthesis genes (ERG).	Ergosterol	148-158	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	99-103
21199190-1	2011	Zn[2]-Cys[6] binuclear transcription factors Upc2p and Ecm22p regulate the expression of genes involved in ergosterol biosynthesis and exogenous sterol uptake in Saccharomyces cerevisiae.	Ergosterol	107-117	Upc2p	Saccharomyces cerevisiae S288C	45-50
21199190-1	2011	Zn[2]-Cys[6] binuclear transcription factors Upc2p and Ecm22p regulate the expression of genes involved in ergosterol biosynthesis and exogenous sterol uptake in Saccharomyces cerevisiae.	Ergosterol	107-117	Ecm22p	Saccharomyces cerevisiae S288C	55-61
20959444-0	2010	Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast.	Ergosterol	0-10	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	64-69
20978158-0	2010	A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.	Ergosterol	82-92	dynactin associated protein	Homo sapiens	14-41
21176163-8	2010	Amongst metabolic SNPs detected, there was pathway enrichment in the galactose uptake pathway (GAL1, GAL10) and ergosterol biosynthetic pathway (ERG8, ERG9).	Ergosterol	112-122	bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase	Saccharomyces cerevisiae S288C	101-106
21176163-8	2010	Amongst metabolic SNPs detected, there was pathway enrichment in the galactose uptake pathway (GAL1, GAL10) and ergosterol biosynthetic pathway (ERG8, ERG9).	Ergosterol	112-122	phosphomevalonate kinase	Saccharomyces cerevisiae S288C	145-149
21176163-8	2010	Amongst metabolic SNPs detected, there was pathway enrichment in the galactose uptake pathway (GAL1, GAL10) and ergosterol biosynthetic pathway (ERG8, ERG9).	Ergosterol	112-122	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	151-155
20659585-3	2010	HSD17B7 is the orthologue of the yeast steroid-3-ketoreductase (ERG27), an enzyme of ergosterol biosynthesis that plays a protective role towards OSC.	Ergosterol	85-95	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	0-7
20659585-3	2010	HSD17B7 is the orthologue of the yeast steroid-3-ketoreductase (ERG27), an enzyme of ergosterol biosynthesis that plays a protective role towards OSC.	Ergosterol	85-95	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	64-69
20870767-9	2010	Erg4 is a yeast Delta24 sterol reductase responsible for the final reduction step in ergosterol synthesis.	Ergosterol	85-95	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	0-4
20870767-11	2010	Heterologous expression of CBU1206 rescued S. cerevisiae erg4 sensitivity to growth in the presence of brefeldin A and cycloheximide and resulted in new synthesis of ergosterol.	Ergosterol	166-176	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	57-61
20733045-2	2010	When cultured in the presence of doxycycline, recombinant YUG37-pcyp51A and YUG37-pcyp51B yeasts were able to synthesize ergosterol and grow; a control strain harboring reverse-oriented cyp51A could not.	Ergosterol	121-131	sterol 14-demethylase	Saccharomyces cerevisiae S288C	65-70
20978158-0	2010	A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.	Ergosterol	82-92	dynactin associated protein	Homo sapiens	43-48
20978158-0	2010	A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.	Ergosterol	82-92	dynactin associated protein	Homo sapiens	118-123
20978158-9	2010	The ergosterol-related compounds identified by the yeast cell-based high-throughput screen abrogated activation of Akt and induced apoptosis in a dynAP-dependent manner.	Ergosterol	4-14	AKT serine/threonine kinase 1	Homo sapiens	115-118
20978158-9	2010	The ergosterol-related compounds identified by the yeast cell-based high-throughput screen abrogated activation of Akt and induced apoptosis in a dynAP-dependent manner.	Ergosterol	4-14	dynactin associated protein	Homo sapiens	146-151
20925360-2	2010	In this study, molecular dynamics simulations were used to investigate the binding of ergosterol, 25-hydroxycholesterol, and lipid moieties to Osh4.	Ergosterol	86-96	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	143-147
20150508-3	2010	We identified mutations in ERG4, encoding the enzyme that catalyzes the last step of ergosterol biosynthesis, that impair both shmoo formation and cell fusion.	Ergosterol	85-95	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	27-31
20545859-7	2010	We also showed that Gal83 is the most important isoform not only for the growth on non-fermentable carbon sources, but also for regulation of ergosterol biosynthetic genes, under glucose-limited condition.	Ergosterol	142-152	Gal83p	Saccharomyces cerevisiae S288C	20-25
20091767-5	2010	Unexpectedly, significant accumulation of squalene and restoring the ergosterol biosynthesis were observed in the ERG9 repressed strains transformed with the plasmids harboring cubebol synthase gene.	Ergosterol	69-79	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	114-118
23956658-5	2010	UPC2 plays roles in ergosterol biosynthesis, which is also affected by the availability of iron in Saccharomyces cerevisiae and Candida albicans.	Ergosterol	20-30	Upc2p	Saccharomyces cerevisiae S288C	0-4
20091767-6	2010	This could be explained by a toxicity effect of cubebol, possibly resulting in higher transcription levels for the genes under control of MET3 promoter, which could lead to accumulation of squalene and ergosterol.	Ergosterol	202-212	sulfate adenylyltransferase	Saccharomyces cerevisiae S288C	138-142
20206679-0	2010	The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae.	Ergosterol	148-158	protein kinase HAL5	Saccharomyces cerevisiae S288C	19-24
20206679-5	2010	The halotolerant protein kinase Hal5p, a regulator of the potassium transporter Trk1p, is shown to be the high-copy suppressor of nearly one third of identified lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as in the biosynthesis of ergosterol.	Ergosterol	272-282	protein kinase HAL5	Saccharomyces cerevisiae S288C	32-37
20206679-5	2010	The halotolerant protein kinase Hal5p, a regulator of the potassium transporter Trk1p, is shown to be the high-copy suppressor of nearly one third of identified lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as in the biosynthesis of ergosterol.	Ergosterol	272-282	Trk1p	Saccharomyces cerevisiae S288C	80-85
19879375-1	2010	In Saccharomyces cerevisiae and Candida albicans, two enzymes of the ergosterol biosynthetic pathway, oxidosqualene cyclase (Erg7p) and 3-keto reductase (Erg27p) interact such that loss of the 3-keto reductase also results in a concomitant loss of activity of the upstream oxidosqualene cyclase.	Ergosterol	69-79	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	125-130
20007700-10	2010	Specific mutants in the ergosterol synthesis pathway block both Sec17p release and Cdc42p activation.	Ergosterol	24-34	Sec17p	Saccharomyces cerevisiae S288C	64-70
20007700-10	2010	Specific mutants in the ergosterol synthesis pathway block both Sec17p release and Cdc42p activation.	Ergosterol	24-34	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	83-89
19879375-1	2010	In Saccharomyces cerevisiae and Candida albicans, two enzymes of the ergosterol biosynthetic pathway, oxidosqualene cyclase (Erg7p) and 3-keto reductase (Erg27p) interact such that loss of the 3-keto reductase also results in a concomitant loss of activity of the upstream oxidosqualene cyclase.	Ergosterol	69-79	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	154-160
19879375-7	2010	Following incubation with radiolabeled and non-radiolabeled 3-ketosteroids we detected differences in hydroxysteroid accumulation and ergosterol production between wild-type and ERG7 mutant strains.	Ergosterol	134-144	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	178-182
20084111-0	2010	Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol.	Ergosterol	115-125	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	61-65
20084111-7	2010	Expression of C. reinhardtii ERG3 cDNA in erg3 null yeast was able to restore ergosterol biosynthesis and reverse phenotypes associated with lack of ERG3 function.	Ergosterol	78-88	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	29-33
20084111-7	2010	Expression of C. reinhardtii ERG3 cDNA in erg3 null yeast was able to restore ergosterol biosynthesis and reverse phenotypes associated with lack of ERG3 function.	Ergosterol	78-88	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	42-46
19783660-3	2009	Using a genome-wide agar-based screening, we demonstrate in this study that S. cerevisiae mutants affected in sphingolipid and ergosterol biosynthesis, namely ipt1, sur1, skn1, and erg3 deletion mutants, are miconazole-resistant, suggesting an involvement of membrane rafts in its mode of action.	Ergosterol	127-137	inositolphosphotransferase	Saccharomyces cerevisiae S288C	159-163
20653936-5	2010	In support of this hypothesis we find that only Saccharomyces becomes more azole resistant in ergosterol-supplemented media; that this depends on sterol importers Aus1 and Pdr11; and that transgenic expression of sterol importers in Kluyveromyces alleviates its drug sensitivity.	Ergosterol	94-104	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	163-167
20653936-5	2010	In support of this hypothesis we find that only Saccharomyces becomes more azole resistant in ergosterol-supplemented media; that this depends on sterol importers Aus1 and Pdr11; and that transgenic expression of sterol importers in Kluyveromyces alleviates its drug sensitivity.	Ergosterol	94-104	ATP-binding cassette multidrug transporter PDR11	Saccharomyces cerevisiae S288C	172-177
20041128-9	2009	Changes in the level of ergosterol and its precursors in cells treated with simvastatin depend on the mutation in the hHMGR gene.	Ergosterol	24-34	high mobility group AT-hook 1	Homo sapiens	118-123
19835945-1	2010	Azoles target the ergosterol synthesizing enzyme lanosterol 14alpha-demethylase and are a widely applied class of antifungal agents.	Ergosterol	18-28	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	49-79
19783660-3	2009	Using a genome-wide agar-based screening, we demonstrate in this study that S. cerevisiae mutants affected in sphingolipid and ergosterol biosynthesis, namely ipt1, sur1, skn1, and erg3 deletion mutants, are miconazole-resistant, suggesting an involvement of membrane rafts in its mode of action.	Ergosterol	127-137	mannosylinositol phosphorylceramide synthase catalytic subunit SUR1	Saccharomyces cerevisiae S288C	165-169
19783660-3	2009	Using a genome-wide agar-based screening, we demonstrate in this study that S. cerevisiae mutants affected in sphingolipid and ergosterol biosynthesis, namely ipt1, sur1, skn1, and erg3 deletion mutants, are miconazole-resistant, suggesting an involvement of membrane rafts in its mode of action.	Ergosterol	127-137	beta-glucan synthesis-associated protein SKN1	Saccharomyces cerevisiae S288C	171-175
19783660-3	2009	Using a genome-wide agar-based screening, we demonstrate in this study that S. cerevisiae mutants affected in sphingolipid and ergosterol biosynthesis, namely ipt1, sur1, skn1, and erg3 deletion mutants, are miconazole-resistant, suggesting an involvement of membrane rafts in its mode of action.	Ergosterol	127-137	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	181-185
19659576-2	2009	When the activity of Erg9 involved in the first step of ergosterol biogenesis, but not that of Erg6 involved in a late step, is compromised, vacuolar degradation of the tryptophan permease Tat2 is promoted.	Ergosterol	56-66	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	21-25
19940936-0	2009	Effects of ergosterol on the structure and activity of Neurospora mitochondrial porin in liposomes.	Ergosterol	11-21	voltage dependent anion channel 1	Homo sapiens	80-85
19940936-8	2009	The presence of ergosterol is associated with an increased change in conformation and loss of function of liposome-embedded porin at high temperature.	Ergosterol	16-26	voltage dependent anion channel 1	Homo sapiens	124-129
19818023-5	2009	Using gas chromatography, we showed that Sre1 and Stp1 are required for both normoxic and hypoxic ergosterol biosynthesis, and therefore cells lacking SRE1 or STP1 are defective for growth in the presence of low levels of the ergosterol biosynthesis inhibitors, itraconazole and 25-thialanosterol.	Ergosterol	98-108	transition protein 1	Homo sapiens	50-54
19818023-5	2009	Using gas chromatography, we showed that Sre1 and Stp1 are required for both normoxic and hypoxic ergosterol biosynthesis, and therefore cells lacking SRE1 or STP1 are defective for growth in the presence of low levels of the ergosterol biosynthesis inhibitors, itraconazole and 25-thialanosterol.	Ergosterol	226-236	transition protein 1	Homo sapiens	50-54
19615977-5	2009	Interestingly, upon ergosterol depletion, the mobility of Cdr1p-GFP did not exhibit appreciable change, while 5-HT(1A)R-EYFP mobility showed an increase.	Ergosterol	20-30	cerebellar degeneration related protein 1	Homo sapiens	58-63
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	139-149	Erg28p	Saccharomyces cerevisiae S288C	164-169
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	139-149	hydroxymethylglutaryl-CoA reductase (NADPH) HMG1	Saccharomyces cerevisiae S288C	171-175
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	139-149	cytochrome-b5 reductase	Saccharomyces cerevisiae S288C	177-181
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	139-149	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	183-187
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	139-149	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	193-197
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	Erg28p	Saccharomyces cerevisiae S288C	164-169
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	hydroxymethylglutaryl-CoA reductase (NADPH) HMG1	Saccharomyces cerevisiae S288C	171-175
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	cytochrome-b5 reductase	Saccharomyces cerevisiae S288C	177-181
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	183-187
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	193-197
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	Erg28p	Saccharomyces cerevisiae S288C	164-169
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	hydroxymethylglutaryl-CoA reductase (NADPH) HMG1	Saccharomyces cerevisiae S288C	171-175
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	cytochrome-b5 reductase	Saccharomyces cerevisiae S288C	177-181
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	183-187
19686341-4	2009	The results of DNA microarray and quantitative reverse transcriptase-polymerase chain reaction analysis showed that five genes involved in ergosterol biosynthesis (ERG28, HMG1, MCR1, ERG5, and ERG7) were upregulated in NBRC 1950 compared with strain X2180, suggesting that high expression of genes involved in ergosterol biosynthesis may cause high ergosterol content in strain NBRC 1950.	Ergosterol	310-320	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	193-197
19659576-2	2009	When the activity of Erg9 involved in the first step of ergosterol biogenesis, but not that of Erg6 involved in a late step, is compromised, vacuolar degradation of the tryptophan permease Tat2 is promoted.	Ergosterol	56-66	aromatic amino acid transmembrane transporter TAT2	Saccharomyces cerevisiae S288C	189-193
19835168-5	2009	In addition,the regulation role of sterol C-24 methyltransferase, encoded by ERG6, in ergosterol biosynthesis was further verified by analysis of sterol components and levels in yeast strains overexpressing ERG6, ERG2 respectively, or overexpressing ERG6 and ERG2 simultaneously.	Ergosterol	86-96	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	77-81
19835168-5	2009	In addition,the regulation role of sterol C-24 methyltransferase, encoded by ERG6, in ergosterol biosynthesis was further verified by analysis of sterol components and levels in yeast strains overexpressing ERG6, ERG2 respectively, or overexpressing ERG6 and ERG2 simultaneously.	Ergosterol	86-96	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	207-211
19835168-5	2009	In addition,the regulation role of sterol C-24 methyltransferase, encoded by ERG6, in ergosterol biosynthesis was further verified by analysis of sterol components and levels in yeast strains overexpressing ERG6, ERG2 respectively, or overexpressing ERG6 and ERG2 simultaneously.	Ergosterol	86-96	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	213-217
19835168-5	2009	In addition,the regulation role of sterol C-24 methyltransferase, encoded by ERG6, in ergosterol biosynthesis was further verified by analysis of sterol components and levels in yeast strains overexpressing ERG6, ERG2 respectively, or overexpressing ERG6 and ERG2 simultaneously.	Ergosterol	86-96	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	207-211
19835168-5	2009	In addition,the regulation role of sterol C-24 methyltransferase, encoded by ERG6, in ergosterol biosynthesis was further verified by analysis of sterol components and levels in yeast strains overexpressing ERG6, ERG2 respectively, or overexpressing ERG6 and ERG2 simultaneously.	Ergosterol	86-96	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	259-263
19835168-6	2009	RESULTS: Ergosterol content and all sterol intermediates increased largely by overexpressing ERG6 in S. cerevisiae.	Ergosterol	9-19	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	93-97
19835168-7	2009	Although the overexpression of sterol C-8 isomerase encoded by ERG2 alone had negative effect on ergosterol biosynthesis, overexpression of ERG6 and ERG2 simultaneously led to an increased ergosterol level, which was 1.41-fold of that in empty vector strain, 1.92-fold of that in ERG2 only overexpressing strain and 1.12-fold of that in ERG6 only overexpressing strain.	Ergosterol	97-107	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	63-67
19835168-7	2009	Although the overexpression of sterol C-8 isomerase encoded by ERG2 alone had negative effect on ergosterol biosynthesis, overexpression of ERG6 and ERG2 simultaneously led to an increased ergosterol level, which was 1.41-fold of that in empty vector strain, 1.92-fold of that in ERG2 only overexpressing strain and 1.12-fold of that in ERG6 only overexpressing strain.	Ergosterol	189-199	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	140-144
19835168-7	2009	Although the overexpression of sterol C-8 isomerase encoded by ERG2 alone had negative effect on ergosterol biosynthesis, overexpression of ERG6 and ERG2 simultaneously led to an increased ergosterol level, which was 1.41-fold of that in empty vector strain, 1.92-fold of that in ERG2 only overexpressing strain and 1.12-fold of that in ERG6 only overexpressing strain.	Ergosterol	189-199	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	149-153
19835168-7	2009	Although the overexpression of sterol C-8 isomerase encoded by ERG2 alone had negative effect on ergosterol biosynthesis, overexpression of ERG6 and ERG2 simultaneously led to an increased ergosterol level, which was 1.41-fold of that in empty vector strain, 1.92-fold of that in ERG2 only overexpressing strain and 1.12-fold of that in ERG6 only overexpressing strain.	Ergosterol	189-199	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	149-153
19835168-7	2009	Although the overexpression of sterol C-8 isomerase encoded by ERG2 alone had negative effect on ergosterol biosynthesis, overexpression of ERG6 and ERG2 simultaneously led to an increased ergosterol level, which was 1.41-fold of that in empty vector strain, 1.92-fold of that in ERG2 only overexpressing strain and 1.12-fold of that in ERG6 only overexpressing strain.	Ergosterol	189-199	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	337-341
19175415-6	2009	The accumulation of ergosterol and unsaturated fatty acids was accompanied by the expression of ERG1, ERG11 and OLE1.	Ergosterol	20-30	squalene monooxygenase	Saccharomyces cerevisiae S288C	96-100
19569196-1	2009	Saccharomyces cerevisiae erg9 mutants blocked at squalene synthase require ergosterol for growth and produce E,E-farnesol.	Ergosterol	75-85	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	25-29
19254924-4	2009	When ergosterol was extracted from membranes, Nha1p was transferred to a detergent-soluble fraction, suggesting that Nha1p associates with ergosterol-containing DRMs, also known as lipid rafts.	Ergosterol	5-15	Nha1p	Saccharomyces cerevisiae S288C	46-51
19254924-4	2009	When ergosterol was extracted from membranes, Nha1p was transferred to a detergent-soluble fraction, suggesting that Nha1p associates with ergosterol-containing DRMs, also known as lipid rafts.	Ergosterol	5-15	Nha1p	Saccharomyces cerevisiae S288C	117-122
19254924-4	2009	When ergosterol was extracted from membranes, Nha1p was transferred to a detergent-soluble fraction, suggesting that Nha1p associates with ergosterol-containing DRMs, also known as lipid rafts.	Ergosterol	139-149	Nha1p	Saccharomyces cerevisiae S288C	117-122
19175415-6	2009	The accumulation of ergosterol and unsaturated fatty acids was accompanied by the expression of ERG1, ERG11 and OLE1.	Ergosterol	20-30	sterol 14-demethylase	Saccharomyces cerevisiae S288C	102-107
19175415-6	2009	The accumulation of ergosterol and unsaturated fatty acids was accompanied by the expression of ERG1, ERG11 and OLE1.	Ergosterol	20-30	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	112-116
19064668-2	2008	We show that 21 proteins cluster within or associate with the ergosterol-rich membrane compartment of Can1 (MCC).	Ergosterol	62-72	arginine permease CAN1	Saccharomyces cerevisiae S288C	102-106
19575637-5	2009	From work with Saccharomyces cerevisiae, much has been learned about glycerophospholipid and ergosterol regulation through Ino2p/Ino4p and Upc2p transcription factors, respectively.	Ergosterol	93-103	Ino4p	Saccharomyces cerevisiae S288C	129-134
19196973-4	2009	For the most prevalent fungal pathogen of humans, Candida albicans, Hsp90 mediates resistance to azoles, which inhibit ergosterol biosynthesis and are the most widely deployed antifungals in the clinic.	Ergosterol	119-129	heat shock protein 90 alpha family class A member 1	Homo sapiens	68-73
19060182-7	2009	A number of mutants had transposon insertions in the uncharacterized Ydr051c gene, which we now refer to as DET1 (decreased ergosterol transport).	Ergosterol	124-134	acid phosphatase DET1	Saccharomyces cerevisiae S288C	108-112
19575637-5	2009	From work with Saccharomyces cerevisiae, much has been learned about glycerophospholipid and ergosterol regulation through Ino2p/Ino4p and Upc2p transcription factors, respectively.	Ergosterol	93-103	Ino2p	Saccharomyces cerevisiae S288C	123-128
19037511-6	2008	Additional products with tachysterol-like (T-like) structures or 5,7-dienes with inverted configuration at C-9 and C-10 (lumisterol, L-like) were also detected.	Ergosterol	121-131	homeobox C10	Homo sapiens	115-119
18555807-0	2008	Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae.	Ergosterol	52-62	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	106-111
18786505-8	2008	Deletion of GUP1 resulted in higher sensibility to specific sphingolipid biosynthesis inhibitors and a notorious resistance to ergosterol biosynthesis inhibitors.	Ergosterol	127-137	O-acyltransferase	Saccharomyces cerevisiae S288C	12-16
18574605-3	2008	25-Azalanosterol inhibited the incorporation of [methyl-(3)H(3)] AdoMet into the C-24 of ergosterol in whole cells of C. albicans.	Ergosterol	89-99	methionine adenosyltransferase I, alpha	Mus musculus	65-71
18771750-2	2008	Here we show that the conditional mutant rsp5-19 produces decreased levels of the end products of mevalonate pathway, such as ergosterol, ubiquinone and of dolichols, especially those with 19-24 isoprene units.	Ergosterol	126-136	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	41-45
18675371-2	2008	Paralogous zinc cluster transcription factors Upc2p and Ecm22p are major regulators of ergosterol biosynthesis in Saccharomyces cerevisiae.	Ergosterol	87-97	Upc2p	Saccharomyces cerevisiae S288C	46-51
18675371-2	2008	Paralogous zinc cluster transcription factors Upc2p and Ecm22p are major regulators of ergosterol biosynthesis in Saccharomyces cerevisiae.	Ergosterol	87-97	Ecm22p	Saccharomyces cerevisiae S288C	56-62
18675371-6	2008	Perinuclear localization of Upc2p-GFP and Ecm22p-GFP was increased when ergosterol biosynthesis was blocked by azole drug treatment.	Ergosterol	72-82	Upc2p	Saccharomyces cerevisiae S288C	28-33
18675371-6	2008	Perinuclear localization of Upc2p-GFP and Ecm22p-GFP was increased when ergosterol biosynthesis was blocked by azole drug treatment.	Ergosterol	72-82	Ecm22p	Saccharomyces cerevisiae S288C	42-48
18555807-0	2008	Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae.	Ergosterol	52-62	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	134-140
18797515-6	2008	Correspondingly, HRG preferentially lysed ergosterol-containing liposomes but not cholesterol-containing ones, indicating a specificity for fungal versus other types of eukaryotic membranes.	Ergosterol	42-52	histidine-rich glycoprotein	Mus musculus	17-20
18533171-0	2008	Development of C18-functionalized magnetic silica nanoparticles as sample preparation technique for the determination of ergosterol in cigarettes by microwave-assisted derivatization and gas chromatography/mass spectrometry.	Ergosterol	121-131	Bardet-Biedl syndrome 9	Homo sapiens	15-18
18187036-6	2008	Disruption of the ergosterol pathway, by knocking out either ERG3 or ERG6, prevents the changes in anisotropy during H2O2 adaptation.	Ergosterol	18-28	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	61-65
18495843-8	2008	Fis1 was inserted into lipid vesicles, and importantly, elevated ergosterol contents in these vesicles inhibited this insertion.	Ergosterol	65-75	Fis1p	Saccharomyces cerevisiae S288C	0-4
18358828-0	2008	Cholesterol, lanosterol, and ergosterol attenuate the membrane association of LL-37(W27F) and temporin L.	Ergosterol	29-39	cathelicidin antimicrobial peptide	Homo sapiens	78-83
18358828-8	2008	At X(Sterol)=0.5 cholesterol was most effective in reducing the membrane intercalation of both LL-37(F27W) and TemL, the corresponding efficiencies of the three sterols decreasing as cholesterol>lanosterol> or =ergosterol, and cholesterol>lanosterol>ergosterol.	Ergosterol	217-227	cathelicidin antimicrobial peptide	Homo sapiens	95-100
18358828-8	2008	At X(Sterol)=0.5 cholesterol was most effective in reducing the membrane intercalation of both LL-37(F27W) and TemL, the corresponding efficiencies of the three sterols decreasing as cholesterol>lanosterol> or =ergosterol, and cholesterol>lanosterol>ergosterol.	Ergosterol	262-272	cathelicidin antimicrobial peptide	Homo sapiens	95-100
18187036-6	2008	Disruption of the ergosterol pathway, by knocking out either ERG3 or ERG6, prevents the changes in anisotropy during H2O2 adaptation.	Ergosterol	18-28	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	69-73
17954932-2	2007	In particular, the P450 protein Erg11/Cyp51 catalyzes a critical step in ergosterol synthesis, and the azole class of antifungal drugs inhibits Erg11.	Ergosterol	73-83	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	19-23
18094052-3	2008	We show that under UFA shortage, which results in low amounts of diunsaturated phospholipid species, and under ergosterol depletion, Fur4p is prematurely routed from the Golgi apparatus to the vacuolar lumen in a process that requires the ubiquitin ligase Rsp5p.	Ergosterol	111-121	uracil permease	Saccharomyces cerevisiae S288C	133-138
18094052-6	2008	In light of recent literature, we propose a model in which ergosterol and diunsaturated phospholipid species maintain optimal membrane curvature for Fur4p to evade the Golgi quality control process and to be properly delivered to its normal destination.	Ergosterol	59-69	uracil permease	Saccharomyces cerevisiae S288C	149-154
18299351-2	2008	In signaling, ergosterol participates in the recruitment of Ste5 to a polarized site on the plasma membrane.	Ergosterol	14-24	Ste5p	Saccharomyces cerevisiae S288C	60-64
17999396-11	2008	A conformational search of the AmB-ergosterol conjugate by using distance constraints derived from the RDX results suggested that ergosterol molecules possibly surround the AmB assembly, which is in contrast with the conventional image in which ergosterol is inserted into AmB molecules.	Ergosterol	35-45	radixin	Homo sapiens	103-106
17999396-11	2008	A conformational search of the AmB-ergosterol conjugate by using distance constraints derived from the RDX results suggested that ergosterol molecules possibly surround the AmB assembly, which is in contrast with the conventional image in which ergosterol is inserted into AmB molecules.	Ergosterol	130-140	radixin	Homo sapiens	103-106
17999396-11	2008	A conformational search of the AmB-ergosterol conjugate by using distance constraints derived from the RDX results suggested that ergosterol molecules possibly surround the AmB assembly, which is in contrast with the conventional image in which ergosterol is inserted into AmB molecules.	Ergosterol	130-140	radixin	Homo sapiens	103-106
17909855-5	2008	The proteins belong to a small cytochrome P450 subfamily having four members, denoted by CYP710A1-A4, and are related to the yeast sterol C-22 desaturase Erg5p acting in ergosterol synthesis.	Ergosterol	170-180	cytochrome P450, family 710, subfamily A, polypeptide 1	Arabidopsis thaliana	89-97
17909855-5	2008	The proteins belong to a small cytochrome P450 subfamily having four members, denoted by CYP710A1-A4, and are related to the yeast sterol C-22 desaturase Erg5p acting in ergosterol synthesis.	Ergosterol	170-180	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	154-159
18031064-1	2007	Current studies on the Saccharomyces cerevisiae protein Dap1p have demonstrated a heme-related function within the ergosterol biosynthetic pathway.	Ergosterol	115-125	Dap1p	Saccharomyces cerevisiae S288C	56-61
18031064-3	2007	First, we examined the role of Dap1p in stabilizing the P450 enzyme, Erg11p, a key regulatory protein in ergosterol biosynthesis.	Ergosterol	105-115	Dap1p	Saccharomyces cerevisiae S288C	31-36
18031064-3	2007	First, we examined the role of Dap1p in stabilizing the P450 enzyme, Erg11p, a key regulatory protein in ergosterol biosynthesis.	Ergosterol	105-115	sterol 14-demethylase	Saccharomyces cerevisiae S288C	69-75
18031064-8	2007	Although previous reports show the weaker affinity of Dap1pY138F for ferric heme lowers the production of ergosterol with respect to wild-type Dap1p in S. pombe, we find that Dap1pY138F expression is still sufficient to rescue the growth sensitivity of dap1Delta to fluconazole and methyl methanesulfonate in S. cerevisiae.	Ergosterol	106-116	Dap1p	Saccharomyces cerevisiae S288C	54-59
17954932-2	2007	In particular, the P450 protein Erg11/Cyp51 catalyzes a critical step in ergosterol synthesis, and the azole class of antifungal drugs inhibits Erg11.	Ergosterol	73-83	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	38-43
17689976-3	2007	Reduction of ergosterol, considered to be a key component of lipid rafts in Drosophila, resulted in a loss of INAD-signaling complexes associated with DRM fractions.	Ergosterol	13-23	inactivation no afterpotential D	Drosophila melanogaster	110-114
17785431-4	2007	The repressive activity of Hap1 controls several genes, including three ERG genes required for ergosterol biosynthesis.	Ergosterol	95-105	Hap1p	Saccharomyces cerevisiae S288C	27-31
17569082-5	2007	Functional characterization with heterologous expression using an erg1-disrupted yeast mutant KLN1 indicated that the EtSE recovered ergosterol auxotrophy of the mutant, and gave rise to an ergosterol accumulation in the EtSE transformant.	Ergosterol	133-143	squalene monooxygenase	Saccharomyces cerevisiae S288C	66-70
17569082-5	2007	Functional characterization with heterologous expression using an erg1-disrupted yeast mutant KLN1 indicated that the EtSE recovered ergosterol auxotrophy of the mutant, and gave rise to an ergosterol accumulation in the EtSE transformant.	Ergosterol	190-200	squalene monooxygenase	Saccharomyces cerevisiae S288C	66-70
17595166-6	2007	Both increases and decreases in the level of these ergosterol pathway intermediates induce Sre1 proteolysis in a Scp1-dependent manner.	Ergosterol	51-61	synaptonemal complex protein 1	Homo sapiens	113-117
16436713-1	2006	Candida albicans ERG3 encodes a sterol C5,6-desaturase which is essential for synthesis of ergosterol.	Ergosterol	91-101	potassium voltage-gated channel, subfamily H (eag-related), member 7	Mus musculus	17-21
17552234-4	2007	As an enzyme of the later ergosterol biosynthesis, the sterol C-22 desaturase encoded by ERG5 gene is required to form the C-22 (23) double bond in the sterol side chain.	Ergosterol	26-36	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	89-93
17552234-5	2007	In order to know the regulation of C-22 sterol desaturase in the ergosterol biosynthesis, ERG5 gene was cloned and over-expressed in the Saccharomyces cerevisiae.	Ergosterol	65-75	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	90-94
16783004-1	2006	Upc2p and Ecm22p are a pair of transcription factors responsible for the basal and induced expression of genes encoding enzymes of ergosterol biosynthesis in yeast (ERG genes).	Ergosterol	131-141	Upc2p	Saccharomyces cerevisiae S288C	0-5
16783004-1	2006	Upc2p and Ecm22p are a pair of transcription factors responsible for the basal and induced expression of genes encoding enzymes of ergosterol biosynthesis in yeast (ERG genes).	Ergosterol	131-141	Ecm22p	Saccharomyces cerevisiae S288C	10-16
16757619-5	2006	Phylogenetic trees inferred from an ergosterol biosynthesis gene (erg-3) were highly discordant with those inferred from the three other partial gene sequences; therefore, this partition was analyzed separately.	Ergosterol	36-46	ETS transcription factor ERG	Homo sapiens	66-71
16598690-0	2006	Involvement of yeast YOL151W/GRE2 in ergosterol metabolism.	Ergosterol	37-47	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	29-33
16598690-3	2006	Combining quantitative phenotypic profiling and protein expression analysis studies, we here report the involvement of yeast Gre2p in ergosterol metabolism.	Ergosterol	134-144	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	125-130
16598690-5	2006	Furthermore, whereas no compensatory mechanisms were activated due to loss of Gre2p during growth in favourable conditions (synthetic defined media, no stress), a striking and highly specific induction of the ergosterol biosynthesis pathway, represented by the enzymes Erg10p, Erg19p and Erg6p, was observed in gre2Delta during growth in a stress condition in which lack of Gre2p significantly affects growth.	Ergosterol	209-219	acetyl-CoA C-acetyltransferase	Saccharomyces cerevisiae S288C	269-275
16598690-6	2006	Involvement of Gre2p in ergosterol metabolism was confirmed by application of an array of selective inhibitors of lipid biosynthesis, as gre2Delta displayed vastly impaired tolerance exclusively to agents targeting the ergosterol biosynthesis.	Ergosterol	24-34	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	15-20
16598690-6	2006	Involvement of Gre2p in ergosterol metabolism was confirmed by application of an array of selective inhibitors of lipid biosynthesis, as gre2Delta displayed vastly impaired tolerance exclusively to agents targeting the ergosterol biosynthesis.	Ergosterol	219-229	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	15-20
16585271-4	2006	We demonstrate that a representative member of this family, Osh4p/Kes1p, specifically facilitates the nonvesicular transfer of cholesterol and ergosterol between membranes in vitro.	Ergosterol	143-153	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	60-65
16585271-4	2006	We demonstrate that a representative member of this family, Osh4p/Kes1p, specifically facilitates the nonvesicular transfer of cholesterol and ergosterol between membranes in vitro.	Ergosterol	143-153	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	66-71
16010571-4	2006	In Saccharomyces cerevisiae, one of the main reactions consuming SAM is thought to be the methylation reaction in the biosynthesis of ergosterol that is catalyzed by Erg6p.	Ergosterol	134-144	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	166-171
16010571-10	2006	These results indicate that mutants having mutations in the genes for enzymes that act downstream of Erg6p in ergosterol biosynthesis are effective in accumulating SAM.	Ergosterol	110-120	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	101-106
17531951-0	2007	The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast.	Ergosterol	4-14	aromatic amino acid transmembrane transporter TAT2	Saccharomyces cerevisiae S288C	110-115
17531951-2	2007	Deletion of the ERG6 gene, which encodes an enzyme catalyzing a late step of ergosterol biosynthesis, impedes targeting of the tryptophan permease Tat2p to the plasma membrane, but does not promote vacuolar degradation.	Ergosterol	77-87	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	16-20
17531951-4	2007	We show herein that the ergosterol biosynthesis inhibitor zaragozic acid (ZA) evoked massive vacuolar degradation of Tat2p, accompanied by a decrease in tryptophan uptake.	Ergosterol	24-34	aromatic amino acid transmembrane transporter TAT2	Saccharomyces cerevisiae S288C	117-122
17029589-10	2007	Paclitaxel-stimulated ATPase activity of MDR1 is enhanced in the presence of stigmasterol, sitosterol and campesterol, as well as cholesterol, but not ergosterol.	Ergosterol	151-161	ATP binding cassette subfamily B member 1	Homo sapiens	41-45
17160010-8	2007	Ergosterol peroxide and ergosterol suppressed LPS-induced DNA binding activity of NF-kappaB and C/EBPbeta, and inhibited the phosphorylation of p38, JNK and ERK MAPKs.	Ergosterol	24-34	CCAAT enhancer binding protein beta	Homo sapiens	96-105
17160010-8	2007	Ergosterol peroxide and ergosterol suppressed LPS-induced DNA binding activity of NF-kappaB and C/EBPbeta, and inhibited the phosphorylation of p38, JNK and ERK MAPKs.	Ergosterol	24-34	mitogen-activated protein kinase 14	Homo sapiens	144-147
17160010-8	2007	Ergosterol peroxide and ergosterol suppressed LPS-induced DNA binding activity of NF-kappaB and C/EBPbeta, and inhibited the phosphorylation of p38, JNK and ERK MAPKs.	Ergosterol	24-34	mitogen-activated protein kinase 8	Homo sapiens	149-152
17160010-12	2007	CONCLUSION AND IMPLICATION: Our results suggest that ergosterol peroxide and ergosterol suppress LPS-induced inflammatory responses through inhibition of NF-kappaB and C/EBPbeta transcriptional activity, and phosphorylation of MAPKs.	Ergosterol	53-63	CCAAT enhancer binding protein beta	Homo sapiens	168-177
16910123-2	2006	They act by inhibiting the cytochrome P-450 conversion of lanosterol to ergosterol, thus resulting in faulty fungal cell wall synthesis.	Ergosterol	72-82	cytochrome P450 family 4 subfamily V member 2, gene 2 L homeolog	Xenopus laevis	27-43
16436713-4	2006	In this study, we created a C. albicans erg3/erg3 mutant by the "Ura-blaster" method and confirmed the expected azole resistance using standard in vitro testing and the presence of ergosta-7,22-dien-3beta-ol instead of ergosterol.	Ergosterol	219-229	potassium voltage-gated channel, subfamily H (eag-related), member 7	Mus musculus	40-44
16436713-4	2006	In this study, we created a C. albicans erg3/erg3 mutant by the "Ura-blaster" method and confirmed the expected azole resistance using standard in vitro testing and the presence of ergosta-7,22-dien-3beta-ol instead of ergosterol.	Ergosterol	219-229	potassium voltage-gated channel, subfamily H (eag-related), member 7	Mus musculus	45-49
18360572-6	2005	Itraconazole works by inhibiting ergosterol synthesis via cytochrome P-450 (CYP450)-dependent demethylation step.	Ergosterol	33-43	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	58-74
16961575-1	2006	Posaconazole, a new triazole antifungal, exerts principally the same mechanism of action as the other azole derivatives, i.e. it inhibits the ergosterol production by binding and inhibiting the lanosterol-14alpha-demethylase which is present in almost all fungi except Pneumocystis and Pythium.	Ergosterol	142-152	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	194-224
16195350-3	2005	We found that the cdc50Delta mutation is synthetically lethal with mutations affecting the late steps of ergosterol synthesis (erg2 to erg6).	Ergosterol	105-115	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	135-139
18360572-6	2005	Itraconazole works by inhibiting ergosterol synthesis via cytochrome P-450 (CYP450)-dependent demethylation step.	Ergosterol	33-43	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	76-82
16246080-1	2005	Squalene epoxidase (Erg1p) is an essential enzyme in the ergosterol biosynthesis pathway in yeast.	Ergosterol	57-67	squalene monooxygenase	Saccharomyces cerevisiae S288C	20-25
16141212-0	2005	Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants.	Ergosterol	60-70	sphinganine kinase LCB4	Saccharomyces cerevisiae S288C	51-56
16141212-5	2005	Of these eight, four are ergosterol-related genes (HEM14, HMG1, KES1, and ERG5).	Ergosterol	25-35	oxygen-dependent protoporphyrinogen oxidase	Saccharomyces cerevisiae S288C	51-56
16141212-5	2005	Of these eight, four are ergosterol-related genes (HEM14, HMG1, KES1, and ERG5).	Ergosterol	25-35	hydroxymethylglutaryl-CoA reductase (NADPH) HMG1	Saccharomyces cerevisiae S288C	58-62
16141212-5	2005	Of these eight, four are ergosterol-related genes (HEM14, HMG1, KES1, and ERG5).	Ergosterol	25-35	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	64-68
16141212-5	2005	Of these eight, four are ergosterol-related genes (HEM14, HMG1, KES1, and ERG5).	Ergosterol	25-35	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	74-78
16141212-7	2005	In addition, phosphorylation of Lcb4p was decreased in all the ergosterol-related mutants isolated and other ergosterol mutants constructed (Deltaerg2, Deltaerg3, and Deltaerg6).	Ergosterol	63-73	sphinganine kinase LCB4	Saccharomyces cerevisiae S288C	32-37
16141212-7	2005	In addition, phosphorylation of Lcb4p was decreased in all the ergosterol-related mutants isolated and other ergosterol mutants constructed (Deltaerg2, Deltaerg3, and Deltaerg6).	Ergosterol	109-119	sphinganine kinase LCB4	Saccharomyces cerevisiae S288C	32-37
16181693-3	2005	This method permits the detection and identification of ergosterol molecules at a concentration of 40 microg/ml (n=33, sigma=5).	Ergosterol	56-66	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	119-126
16135527-8	2005	Among these, genes were highly enriched that encode proteins involved in ergosterol biosynthesis, mitochondrial protein import, actin-dependent transport processes, vesicular trafficking, and ubiquitin/26S proteasome-dependent protein degradation.	Ergosterol	73-83	actin	Saccharomyces cerevisiae S288C	128-133
16136145-2	2005	Here we report the structure of the full-length yeast ORP Osh4 (also known as Kes1) at 1.5-1.9 A resolution in complexes with ergosterol, cholesterol, and 7-, 20- and 25-hydroxycholesterol.	Ergosterol	126-136	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	58-62
16096648-3	2005	The coiled-coil domain of Osh7p was found to interact with Vps4p in a yeast two-hybrid screen and the interaction between Osh7p and Vps4p appears to be regulated by ergosterol.	Ergosterol	165-175	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	26-31
16096648-3	2005	The coiled-coil domain of Osh7p was found to interact with Vps4p in a yeast two-hybrid screen and the interaction between Osh7p and Vps4p appears to be regulated by ergosterol.	Ergosterol	165-175	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	122-127
16096648-3	2005	The coiled-coil domain of Osh7p was found to interact with Vps4p in a yeast two-hybrid screen and the interaction between Osh7p and Vps4p appears to be regulated by ergosterol.	Ergosterol	165-175	AAA family ATPase VPS4	Saccharomyces cerevisiae S288C	132-137
16127034-2	2005	Both isolates harbored homozygous nonsense mutations in ERG3, which encodes an enzyme, sterol Delta5,6-desaturase, involved in ergosterol synthesis.	Ergosterol	127-137	potassium voltage-gated channel, subfamily H (eag-related), member 7	Mus musculus	56-60
16127034-11	2005	Reintroduction of a wild-type ERG3 allele into the homozygous deletion mutant restored virulence, ergosterol synthesis, and susceptibility to azoles, confirming that these phenotypic changes were solely due to the inactivation of Erg3p.	Ergosterol	98-108	potassium voltage-gated channel, subfamily H (eag-related), member 7	Mus musculus	30-34
16156791-6	2005	Functional analysis showed that the deletion of OSH6 led to a significant increase in total cellular ergosterols, whereas OSH6 overexpression caused both a significant decrease in ergosterol levels and resistance to nystatin.	Ergosterol	101-112	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	48-52
16156791-6	2005	Functional analysis showed that the deletion of OSH6 led to a significant increase in total cellular ergosterols, whereas OSH6 overexpression caused both a significant decrease in ergosterol levels and resistance to nystatin.	Ergosterol	101-111	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	48-52
16136145-2	2005	Here we report the structure of the full-length yeast ORP Osh4 (also known as Kes1) at 1.5-1.9 A resolution in complexes with ergosterol, cholesterol, and 7-, 20- and 25-hydroxycholesterol.	Ergosterol	126-136	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	78-82
16125105-0	2005	Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol.	Ergosterol	24-34	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	49-56
15995173-1	2005	Previously, a microarray expression study in the yeast Saccharomyces cerevisiae indicated that the ERG28 gene was strongly coregulated with ergosterol biosynthesis.	Ergosterol	140-150	Erg28p	Saccharomyces cerevisiae S288C	99-104
15995173-6	2005	Interactions between Erg28p and seven ergosterol biosynthetic enzymes were confirmed by coimmunoprecipitation experiments.	Ergosterol	38-48	Erg28p	Saccharomyces cerevisiae S288C	21-27
16125105-1	2005	We demonstrate the metabolism of ergosterol by cytochrome P450scc in either a reconstituted system or isolated adrenal mitochondria.	Ergosterol	33-43	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	58-65
16125105-7	2005	Thus, in comparison with cholesterol and 7-dehydrocholesterol, the 24-methyl group and the C22-C23 double bond of ergosterol prevent side chain cleavage by P450scc and change the enzyme"s hydroxylase activity from C22 and C20, to C24 and C17, generating bioactive product.	Ergosterol	114-124	nucleolin	Homo sapiens	95-98
16125105-7	2005	Thus, in comparison with cholesterol and 7-dehydrocholesterol, the 24-methyl group and the C22-C23 double bond of ergosterol prevent side chain cleavage by P450scc and change the enzyme"s hydroxylase activity from C22 and C20, to C24 and C17, generating bioactive product.	Ergosterol	114-124	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	156-163
16125105-7	2005	Thus, in comparison with cholesterol and 7-dehydrocholesterol, the 24-methyl group and the C22-C23 double bond of ergosterol prevent side chain cleavage by P450scc and change the enzyme"s hydroxylase activity from C22 and C20, to C24 and C17, generating bioactive product.	Ergosterol	114-124	cytokine like 1	Homo sapiens	238-241
16055745-2	2005	Two transcription factors, Upc2p and Ecm22p, bind to the promoters of most ergosterol biosynthetic (ERG) genes, including ERG2 and ERG3, and activate these genes upon sterol depletion.	Ergosterol	75-85	Upc2p	Saccharomyces cerevisiae S288C	27-32
16055745-2	2005	Two transcription factors, Upc2p and Ecm22p, bind to the promoters of most ergosterol biosynthetic (ERG) genes, including ERG2 and ERG3, and activate these genes upon sterol depletion.	Ergosterol	75-85	Ecm22p	Saccharomyces cerevisiae S288C	37-43
16055745-2	2005	Two transcription factors, Upc2p and Ecm22p, bind to the promoters of most ergosterol biosynthetic (ERG) genes, including ERG2 and ERG3, and activate these genes upon sterol depletion.	Ergosterol	75-85	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	122-126
16055745-2	2005	Two transcription factors, Upc2p and Ecm22p, bind to the promoters of most ergosterol biosynthetic (ERG) genes, including ERG2 and ERG3, and activate these genes upon sterol depletion.	Ergosterol	75-85	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	131-135
15855491-0	2005	Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes.	Ergosterol	106-116	Upc2p	Saccharomyces cerevisiae S288C	38-43
15855491-4	2005	In Saccharomyces cerevisiae, two highly related transcriptional activators, Upc2p and Ecm22p, positively regulate the expression of genes involved in ergosterol synthesis (ERG genes).	Ergosterol	150-160	Upc2p	Saccharomyces cerevisiae S288C	76-81
15855491-4	2005	In Saccharomyces cerevisiae, two highly related transcriptional activators, Upc2p and Ecm22p, positively regulate the expression of genes involved in ergosterol synthesis (ERG genes).	Ergosterol	150-160	Ecm22p	Saccharomyces cerevisiae S288C	86-92
15713626-7	2005	Thus, Dap1p utilizes heme to stabilize Erg11p, which in turn regulates ergosterol synthesis and MMS resistance.	Ergosterol	71-81	Dap1p	Saccharomyces cerevisiae S288C	6-11
15713626-7	2005	Thus, Dap1p utilizes heme to stabilize Erg11p, which in turn regulates ergosterol synthesis and MMS resistance.	Ergosterol	71-81	sterol 14-demethylase	Saccharomyces cerevisiae S288C	39-45
15827618-7	2005	Low expression of Erg20p in rsp5 cells was accompanied by low level of ergosterol, the main end product of the isoprenoid pathway.	Ergosterol	71-81	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	18-24
15827618-7	2005	Low expression of Erg20p in rsp5 cells was accompanied by low level of ergosterol, the main end product of the isoprenoid pathway.	Ergosterol	71-81	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	28-32
15827618-8	2005	Additionally, rsp5 strains were resistant to nystatin, which binds to ergosterol present in the plasma membrane, and sensitive to calcofluor white, a drug destabilizing cell wall integrity by binding to chitin.	Ergosterol	70-80	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	14-18
15827618-10	2005	These results indicate that Rsp5p affects the isoprenoid pathway which has important roles in ergosterol biosynthesis, protein glycosylation and transport and in this way may influence the composition of the plasma membrane and cell wall.	Ergosterol	94-104	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	28-33
15590814-2	2004	A search of the C. albicans genome identified a single homolog of the S. cerevisiae transcription factor genes UPC2 (ScUPC2) and ECM22 (ScECM22) that have been associated with regulation of ergosterol biosynthesis.	Ergosterol	190-200	Upc2p	Saccharomyces cerevisiae S288C	111-115
15590814-2	2004	A search of the C. albicans genome identified a single homolog of the S. cerevisiae transcription factor genes UPC2 (ScUPC2) and ECM22 (ScECM22) that have been associated with regulation of ergosterol biosynthesis.	Ergosterol	190-200	Ecm22p	Saccharomyces cerevisiae S288C	129-134
15142031-10	2004	Our data show that the yeast 14-3-3 proteins negatively regulate Rtg3-dependent transcription, stimulate the transcription of genes involved in ergosterol metabolism and in stress response and are involved in transcription regulation of multiple other genes.	Ergosterol	144-154	Rtg3p	Saccharomyces cerevisiae S288C	65-69
15522820-7	2004	We conclude that Erg28p may not only anchor the C-4 demethylation enzyme complex to the ER but also acts as a protein bridge to the Erg6p enzyme required for the next ergosterol biosynthetic step.	Ergosterol	167-177	Erg28p	Saccharomyces cerevisiae S288C	17-23
15522820-7	2004	We conclude that Erg28p may not only anchor the C-4 demethylation enzyme complex to the ER but also acts as a protein bridge to the Erg6p enzyme required for the next ergosterol biosynthetic step.	Ergosterol	167-177	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	132-137
15388447-6	2004	Eleven of the 20 genes are involved in cell wall and membrane function, notably in the protein kinase C (PKC) integrity pathway (MID2, FKS1, SMI1, and BCK1), chitin and mannan biosynthesis (CHS3, CHS4, CHS7, and MNN10), and ergosterol biosynthesis (ERG5 and ERG6).	Ergosterol	224-234	chitin synthase CHS3	Saccharomyces cerevisiae S288C	190-194
15328107-10	2004	The C. albicans cyb5 strains produced a sterol profile containing low ergosterol levels and sterol intermediates similar to that reported for the S. cerevisiae cyb5.	Ergosterol	70-80	Cyb5p	Saccharomyces cerevisiae S288C	16-20
15201233-8	2004	In addition to the cell stress genes DDR48 and RTA2, the ergosterol biosynthesis genes ERG5, ERG6 and ERG25 were up-regulated.	Ergosterol	57-67	C-22 sterol desaturase	Candida albicans SC5314	87-91
15464432-0	2004	Lowered DHCR7 activity measured by ergosterol conversion in multiple cell types in Smith-Lemli-Opitz syndrome.	Ergosterol	35-45	7-dehydrocholesterol reductase	Homo sapiens	8-13
15201233-8	2004	In addition to the cell stress genes DDR48 and RTA2, the ergosterol biosynthesis genes ERG5, ERG6 and ERG25 were up-regulated.	Ergosterol	57-67	sterol 24-C-methyltransferase	Candida albicans SC5314	93-97
15155725-11	2004	In a strain lacking the two STE synthases, Are1p and Are2p, incorporation of ergosterol into the plasma membrane was reduced, although the total cellular amount of free ergosterol was higher in the mutant than in wild type.	Ergosterol	77-87	sterol acyltransferase	Saccharomyces cerevisiae S288C	43-48
15638242-7	2004	The sterol composition of the upc2delta ecm22delta double mutant reflected regulation of the latter part of the ergosterol synthesis by the Upc2p and Ecm22p transcription factors.	Ergosterol	112-122	Upc2p	Saccharomyces cerevisiae S288C	140-145
15155725-11	2004	In a strain lacking the two STE synthases, Are1p and Are2p, incorporation of ergosterol into the plasma membrane was reduced, although the total cellular amount of free ergosterol was higher in the mutant than in wild type.	Ergosterol	77-87	sterol acyltransferase	Saccharomyces cerevisiae S288C	53-58
15155725-11	2004	In a strain lacking the two STE synthases, Are1p and Are2p, incorporation of ergosterol into the plasma membrane was reduced, although the total cellular amount of free ergosterol was higher in the mutant than in wild type.	Ergosterol	169-179	sterol acyltransferase	Saccharomyces cerevisiae S288C	43-48
15155725-11	2004	In a strain lacking the two STE synthases, Are1p and Are2p, incorporation of ergosterol into the plasma membrane was reduced, although the total cellular amount of free ergosterol was higher in the mutant than in wild type.	Ergosterol	169-179	sterol acyltransferase	Saccharomyces cerevisiae S288C	53-58
15215098-2	2004	CgERG1 encodes a 489-amino-acid protein which, on the basis of its homology with Saccharomyces cerevisiae ERG1, is a squalene epoxidase essential for ergosterol synthesis.	Ergosterol	150-160	squalene monooxygenase	Saccharomyces cerevisiae S288C	2-6
15191747-0	2004	Ergosterol elicits oxidative burst in tobacco cells via phospholipase A2 and protein kinase C signal pathway.	Ergosterol	0-10	phospholipase A2-alpha-like	Nicotiana tabacum	56-72
15191747-8	2004	On the other hand, the activity of phospholipase A2 (PLA2) measured using a fluorogenic substrate was stimulated by ergosterol and not by cholesterol and cryptogein.	Ergosterol	116-126	phospholipase A2-alpha-like	Nicotiana tabacum	35-51
15191747-8	2004	On the other hand, the activity of phospholipase A2 (PLA2) measured using a fluorogenic substrate was stimulated by ergosterol and not by cholesterol and cryptogein.	Ergosterol	116-126	phospholipase A2-alpha-like	Nicotiana tabacum	53-57
15191747-9	2004	A specific inhibitor of PLA2, arachidonic acid trifluoromethyl ketone (AACOCF3), inhibited the pathway stimulated by ergosterol but not that induced by cryptogein.	Ergosterol	117-127	phospholipase A2-alpha-like	Nicotiana tabacum	24-28
14712470-3	2004	KTZ blocks ergosterol biosynthesis by inhibiting the fungal cytochrome P450 (CYP51).	Ergosterol	11-21	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	77-82
14599667-7	2003	Tc14DM was able to complement the function of the homologous gene in yeast (erg11) as demonstrated by restored ergosterol production in an erg11-deficient yeast strain.	Ergosterol	111-121	sterol 14-demethylase	Saccharomyces cerevisiae S288C	76-81
14551669-10	2004	Quantification using a PLS1 regression algorithm showed good correlation with DON reference data, but a rather high standard error of prediction (SEP) with 600 microg/kg (DR) and 490 microg/kg (ATR), respectively, for ergosterol.	Ergosterol	218-228	1-acyl-sn-glycerol-3-phosphate acyltransferase PLS1	Zea mays	23-27
16233684-0	2004	A hap1 mutation in a laboratory strain of Saccharomyces cerevisiae results in decreased expression of ergosterol-related genes and cellular ergosterol content compared to sake yeast.	Ergosterol	102-112	Hap1p	Saccharomyces cerevisiae S288C	2-6
16233684-0	2004	A hap1 mutation in a laboratory strain of Saccharomyces cerevisiae results in decreased expression of ergosterol-related genes and cellular ergosterol content compared to sake yeast.	Ergosterol	140-150	Hap1p	Saccharomyces cerevisiae S288C	2-6
16233684-6	2004	These results suggest that the differences in the expression levels of ergosterol-related genes and ergosterol content between strains K7 and X2180 were largely caused by the hap1 mutation in strain X2180.	Ergosterol	71-81	Hap1p	Saccharomyces cerevisiae S288C	175-179
16233684-6	2004	These results suggest that the differences in the expression levels of ergosterol-related genes and ergosterol content between strains K7 and X2180 were largely caused by the hap1 mutation in strain X2180.	Ergosterol	100-110	Hap1p	Saccharomyces cerevisiae S288C	175-179
14693556-1	2004	The first step in ergosterol biosynthesis in Saccharomyces cerevisiae consists of the condensation of two acetyl coenzyme A (acetyl-CoA) moieties by acetoacetyl-CoA thiolase, encoded by ERG10.	Ergosterol	18-28	acetyl-CoA C-acetyltransferase	Saccharomyces cerevisiae S288C	186-191
14693556-3	2004	A cell-based reporter assay, in which increased ERG10 transcription results in elevated specific beta-galactosidase activity, was used to find novel inhibitors of ergosterol biosynthesis that could serve as chemical starting points for the development of novel antifungal agents.	Ergosterol	163-173	acetyl-CoA C-acetyltransferase	Saccharomyces cerevisiae S288C	48-53
12847102-5	2003	Among them, YT-32 [(22E)-ergost-22-ene-1alpha,3beta-diol], which is related to ergosterol and brassicasterol, is the most potent LXR agonist.	Ergosterol	79-89	nuclear receptor subfamily 1, group H, member 2	Mus musculus	129-132
12963042-4	2003	This novel mutation in the ERG1 gene confers only partial resistance of Erg1p to terbinafine, however, even the low level of resistance enables terbinafine-treated mutant cells to maintain adequate ergosterol levels over longer cultivation periods.	Ergosterol	198-208	squalene monooxygenase	Saccharomyces cerevisiae S288C	27-31
13678596-7	2003	Slow diffusion requires neither the cell wall nor polymerized actin, but it is affected in the ergosterol synthesis mutant erg6.	Ergosterol	95-105	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	123-127
12923296-3	2003	We have shown that ligand binding to reconstituted DmGluRA requires the presence of ergosterol in the liposomes [Eroglu, C., Cronet, P., Panneels, V., Beaufils, P. & Sinning, I.	Ergosterol	84-94	metabotropic Glutamate Receptor	Drosophila melanogaster	51-58
12684380-8	2003	We have found that dap1 cells have slightly decreased levels of ergosterol but increased levels of the ergosterol intermediates squalene and lanosterol, indicating that dap1 cells have a partial defect in sterol synthesis.	Ergosterol	64-74	death associated protein	Homo sapiens	19-23
12902271-4	2003	Additionally, similar ERG10 and TRR1 gene expression patterns over the initial 24-h fermentation period highlighted a possible interaction between ergosterol biosynthesis and the oxidative stress response.	Ergosterol	147-157	acetyl-CoA C-acetyltransferase	Saccharomyces cerevisiae S288C	22-27
12902271-4	2003	Additionally, similar ERG10 and TRR1 gene expression patterns over the initial 24-h fermentation period highlighted a possible interaction between ergosterol biosynthesis and the oxidative stress response.	Ergosterol	147-157	thioredoxin-disulfide reductase TRR1	Saccharomyces cerevisiae S288C	32-36
12842197-3	2003	In a previous study, we found that erg27 strains grown on cholesterol- or ergosterol-supplemented media did not accumulate lanosterol or 3-ketosterols but rather squalene, oxidosqualene, and dioxidosqualene intermediates normally observed in ERG7 (oxidosqualene cyclase) mutants.	Ergosterol	74-84	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	35-40
12842197-3	2003	In a previous study, we found that erg27 strains grown on cholesterol- or ergosterol-supplemented media did not accumulate lanosterol or 3-ketosterols but rather squalene, oxidosqualene, and dioxidosqualene intermediates normally observed in ERG7 (oxidosqualene cyclase) mutants.	Ergosterol	74-84	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	242-246
12810702-1	2003	It was known that the uptake of tryptophan is reduced in the yeast erg6 mutant, which is defective in a late step of ergosterol biosynthesis.	Ergosterol	117-127	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	67-71
12684380-8	2003	We have found that dap1 cells have slightly decreased levels of ergosterol but increased levels of the ergosterol intermediates squalene and lanosterol, indicating that dap1 cells have a partial defect in sterol synthesis.	Ergosterol	103-113	death associated protein	Homo sapiens	19-23
12145211-0	2002	Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae.	Ergosterol	39-49	Mot3p	Saccharomyces cerevisiae S288C	0-4
12546417-1	2002	C-4 sterol methyl oxidase encoded by the ERG25 gene is a key enzyme in the ergosterol biosynthetic pathway in fungi.	Ergosterol	75-85	methylsterol monooxygenase	Saccharomyces cerevisiae S288C	41-46
12690907-4	2003	Estrogen receptor (+) MCF-7 cells appear to be more sensitive to ergosterol than estrogen receptor (-) MDA-231 cells.	Ergosterol	65-75	estrogen receptor 1	Homo sapiens	0-17
12512083-3	2003	We report the construction of the novel Saccharomyces cerevisiae yeast strain DCY250, which is compatible with yeast two-hybrid-based systems and bears a targeted disruption of the ERG6 gene to ablate ergosterol biosynthesis and enhance permeability to small molecules.	Ergosterol	201-211	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	181-185
12680714-4	2003	In TIMM 3164 and 3165, the ergosterol synthesis by cell-free extracts was somewhat less susceptible to fluconazole, due to a decrease in fluconazole affinity for CYP.	Ergosterol	27-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	162-165
12475962-5	2002	We now report that under these conditions, an otherwise nonessential, but also fungal-specific, structural modification of the major sterol of yeast, ergosterol, becomes essential, because mutations in ELO3 are synthetically lethal with mutations in ERG6.	Ergosterol	150-160	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	202-206
12475962-5	2002	We now report that under these conditions, an otherwise nonessential, but also fungal-specific, structural modification of the major sterol of yeast, ergosterol, becomes essential, because mutations in ELO3 are synthetically lethal with mutations in ERG6.	Ergosterol	150-160	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	250-254
12145211-5	2002	Transcriptional analyses show that Mot3 represses transcription of ERG2, ERG6 and ERG9, genes required for ergosterol biosynthesis, during both aerobic and hypoxic growth.	Ergosterol	107-117	Mot3p	Saccharomyces cerevisiae S288C	35-39
12145211-5	2002	Transcriptional analyses show that Mot3 represses transcription of ERG2, ERG6 and ERG9, genes required for ergosterol biosynthesis, during both aerobic and hypoxic growth.	Ergosterol	107-117	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	67-71
12145211-5	2002	Transcriptional analyses show that Mot3 represses transcription of ERG2, ERG6 and ERG9, genes required for ergosterol biosynthesis, during both aerobic and hypoxic growth.	Ergosterol	107-117	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	73-77
12145211-5	2002	Transcriptional analyses show that Mot3 represses transcription of ERG2, ERG6 and ERG9, genes required for ergosterol biosynthesis, during both aerobic and hypoxic growth.	Ergosterol	107-117	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	82-86
12145211-7	2002	Ergosterol has been shown to be required for endocytosis and homotypic vacuole fusion, providing a link between Mot3 and these processes.	Ergosterol	0-10	Mot3p	Saccharomyces cerevisiae S288C	112-116
12145211-9	2002	Taken together, our data suggest that proper transcriptional regulation of ergosterol biosynthetic genes by Mot3 is important for normal vacuolar function and probably for the endocytic membrane transport system.	Ergosterol	75-85	Mot3p	Saccharomyces cerevisiae S288C	108-112
12020638-7	2002	Complementation of the mutant revealed that the ERG4 gene, encoding the enzyme that catalyzes the last step in ergosterol biosynthesis, had been mutated.	Ergosterol	111-121	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	48-52
12119386-1	2002	A Saccharomyces cerevisae microarray expression study indicated that an ORF, YER044C, now designated ERG28, was strongly coregulated with ergosterol biosynthesis.	Ergosterol	138-148	Erg28p	Saccharomyces cerevisiae S288C	101-106
11483507-0	2001	Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion.	Ergosterol	0-10	AAA family ATPase SEC18	Saccharomyces cerevisiae S288C	31-36
11895447-0	2002	Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription.	Ergosterol	24-34	cyclin dependent kinase 1	Homo sapiens	54-58
12702319-6	2002	Additionally, maf1-1 leads to decreased ergosterol content in the cells.	Ergosterol	40-50	RNA polymerase III-inhibiting protein MAF1	Saccharomyces cerevisiae S288C	14-20
12450214-2	2002	In this microorganism, SR31747A was shown to inhibit the ERG2 gene product, namely the delta8-delta7 sterol isomerase, involved in the ergosterol biosynthesis pathway.	Ergosterol	135-145	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	57-61
12450214-9	2002	The detailed analysis of the observed 121 modulated genes provides new insights into the cellular response to ergosterol deprivation induced by SR31747A through inhibition of the ERG2 gene product.	Ergosterol	110-120	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	179-183
11737827-2	2001	Here we show that in Delta erg6 cells, where a late biosynthetic step of the membrane lipid ergosterol is blocked, part of Yps1p was targeted to the vacuole.	Ergosterol	92-102	aspartyl protease	Saccharomyces cerevisiae S288C	123-128
11707264-3	2001	Heterologous expression of AtSMO1 and AtSMO2 in a yeast erg25 ergosterol auxotroph, lacking SMO activity, restored growth and endogenous ergosterol synthesis.	Ergosterol	62-72	sterol C4-methyl oxidase 1-2	Arabidopsis thaliana	27-33
11707264-3	2001	Heterologous expression of AtSMO1 and AtSMO2 in a yeast erg25 ergosterol auxotroph, lacking SMO activity, restored growth and endogenous ergosterol synthesis.	Ergosterol	62-72	sterol 4-alpha-methyl-oxidase 2-1	Arabidopsis thaliana	38-44
11707264-3	2001	Heterologous expression of AtSMO1 and AtSMO2 in a yeast erg25 ergosterol auxotroph, lacking SMO activity, restored growth and endogenous ergosterol synthesis.	Ergosterol	62-72	methylsterol monooxygenase	Saccharomyces cerevisiae S288C	56-61
11489845-6	2001	We present evidence that the primary role of the minor sterol esterification isoform encoded by ARE1 is to esterify sterol intermediates, whereas the role of the ARE2 enzyme is to esterify ergosterol, the end product of the pathway.	Ergosterol	189-199	sterol acyltransferase	Saccharomyces cerevisiae S288C	96-100
11489845-6	2001	We present evidence that the primary role of the minor sterol esterification isoform encoded by ARE1 is to esterify sterol intermediates, whereas the role of the ARE2 enzyme is to esterify ergosterol, the end product of the pathway.	Ergosterol	189-199	sterol acyltransferase	Saccharomyces cerevisiae S288C	162-166
11489845-7	2001	Accordingly, the ARE1 promoter is upregulated in strains that accumulate ergosterol precursors.	Ergosterol	73-83	sterol acyltransferase	Saccharomyces cerevisiae S288C	17-21
11489845-13	2001	Conversely, Are2p is optimally required during aerobiosis when ergosterol is plentiful.	Ergosterol	63-73	sterol acyltransferase	Saccharomyces cerevisiae S288C	12-17
11469860-1	2001	The azole-based P450 inhibitor ketoconazole is used to treat fungal infections and functions by blocking ergosterol biosynthesis in yeast.	Ergosterol	105-115	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	16-20
11179957-7	2001	Inhibition of later steps in the ergosterol-biosynthetic pathway by ketoconazole, an inhibitor of the lanosterol-14alpha-demethylase, and U18666A, an inhibitor of the squalene-2,3-epoxide-lanosterol cyclase, also induce expression of ERG1, suggesting that ERG1 expression is positively regulated by diminished intracellular ergosterol levels.	Ergosterol	33-43	squalene monooxygenase	Saccharomyces cerevisiae S288C	234-238
11298754-7	2001	In addition, several enzymes involved in ergosterol biosynthesis, namely squalene synthase (Erg9p), squalene epoxidase (Erg1p) and steroldelta24-methyltransferase (Erg6p), are highly enriched in PAM.	Ergosterol	41-51	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	92-97
11298754-7	2001	In addition, several enzymes involved in ergosterol biosynthesis, namely squalene synthase (Erg9p), squalene epoxidase (Erg1p) and steroldelta24-methyltransferase (Erg6p), are highly enriched in PAM.	Ergosterol	41-51	squalene monooxygenase	Saccharomyces cerevisiae S288C	120-125
11298754-7	2001	In addition, several enzymes involved in ergosterol biosynthesis, namely squalene synthase (Erg9p), squalene epoxidase (Erg1p) and steroldelta24-methyltransferase (Erg6p), are highly enriched in PAM.	Ergosterol	41-51	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	164-169
11179957-6	2001	Inhibition of ergosterol biosynthesis with terbinafine increases the expression of ERG1 in a concentration-dependent manner to a maximum of sevenfold.	Ergosterol	14-24	squalene monooxygenase	Saccharomyces cerevisiae S288C	83-87
11515543-4	2001	An indicator strain with increased drug sensitivity was constructed with an ergosterol-deficient background (delta syr1/erg3 null mutation).	Ergosterol	76-86	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	115-119
11179957-7	2001	Inhibition of later steps in the ergosterol-biosynthetic pathway by ketoconazole, an inhibitor of the lanosterol-14alpha-demethylase, and U18666A, an inhibitor of the squalene-2,3-epoxide-lanosterol cyclase, also induce expression of ERG1, suggesting that ERG1 expression is positively regulated by diminished intracellular ergosterol levels.	Ergosterol	33-43	squalene monooxygenase	Saccharomyces cerevisiae S288C	256-260
11179957-11	2001	A DNA fragment containing this region confers ergosterol-regulated expression on an otherwise unregulated CYC1 promoter construction.	Ergosterol	46-56	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	106-110
11208779-12	2001	Gas chromatographic analysis of the nonsaponifiable fractions of the various strains showed that the major sterol for all YLR228c and UPC2 combinations was ergosterol, the consensus yeast sterol.	Ergosterol	156-166	Upc2p	Saccharomyces cerevisiae S288C	134-138
10722850-1	2000	The yeast ERG4 gene encodes sterol C-24(28) reductase which catalyzes the final step in the biosynthesis of ergosterol.	Ergosterol	108-118	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	10-14
11342098-0	2001	Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae.	Ergosterol	65-75	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	55-59
10933640-5	2000	It is known that erg3 mutants are azole resistant through the accumulation of 14-methyl-fecosterol, a less toxic ergosterol intermediate.	Ergosterol	113-123	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	17-21
10933641-7	2000	The erg3 mutants are resistant to azoles and accumulate 14-methyl-fecosterol instead of ergosterol in the presence of azoles.	Ergosterol	88-98	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	4-8
10833391-3	2000	Anc2(His(6))p, enriched by chromatography on hydroxyapatite of detergent extracts of mitochondria, was still contaminated by mitochondrial proteins and a large amount of ergosterol.	Ergosterol	170-180	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	0-4
10716729-6	2000	Using lipid biosynthetic mutants we could demonstrate that conditions that impair the synthesis of sphingolipids and ergosterol also disrupt raft association of Gas1p and Pma1p but not the secretion of acid phosphatase.	Ergosterol	117-127	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	161-166
10716729-6	2000	Using lipid biosynthetic mutants we could demonstrate that conditions that impair the synthesis of sphingolipids and ergosterol also disrupt raft association of Gas1p and Pma1p but not the secretion of acid phosphatase.	Ergosterol	117-127	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	171-176
10734216-2	2000	We have taken advantage of this property to study the regulation of the Delta8-Delta7-sterol isomerase-encoding ERG2 gene in an ergosterol auxotrophic mutant devoid of squalene-synthase activity.	Ergosterol	128-138	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	112-116
10734216-3	2000	Ergosterol starvation leads to an 8-16-fold increase in ERG2 gene expression.	Ergosterol	0-10	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	56-60
10734216-5	2000	Exogenously-supplied zymosterol is entirely transformed into ergosterol, which represses ERG2 transcription.	Ergosterol	61-71	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	89-93
11165030-5	2001	17beta-HSD7 shows significant homology to a yeast 3-ketosteroid reductase (ERG27) involved in ergosterol biosynthesis.	Ergosterol	94-104	RNA, U1 small nuclear 4	Homo sapiens	0-11
11165030-5	2001	17beta-HSD7 shows significant homology to a yeast 3-ketosteroid reductase (ERG27) involved in ergosterol biosynthesis.	Ergosterol	94-104	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	50-73
11165030-5	2001	17beta-HSD7 shows significant homology to a yeast 3-ketosteroid reductase (ERG27) involved in ergosterol biosynthesis.	Ergosterol	94-104	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	75-80
11063677-5	2000	LEM3 is a putative transmembrane protein of unknown function, and ERG6 is a methyltransferase in the ergosterol biosynthetic pathway.	Ergosterol	101-111	Lem3p	Saccharomyces cerevisiae S288C	0-4
11063677-5	2000	LEM3 is a putative transmembrane protein of unknown function, and ERG6 is a methyltransferase in the ergosterol biosynthetic pathway.	Ergosterol	101-111	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	66-70
11092966-3	2000	In this work, we tried to prevent aggregation of CYP11A1 and stimulate its insertion into the mitochondrial inner membrane by substituting cholesterol (a substrate for cytochrome P450scc) for ergosterol in yeast cells.	Ergosterol	192-202	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	49-56
11092966-4	2000	To this end, an ergosterol-deficient Saccharomyces cerevisiae mutant, growing in the presence of cholesterol and expressing a modified bovine CYP11A1 gene, was used.	Ergosterol	16-26	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	142-149
10747151-4	2000	35:667-672, 1997), we amplified a fragment of the ERG11 gene for cytochrome P-450 lanosterol 14alpha-demethylase, a crucial enzyme in the biosynthesis of ergosterol.	Ergosterol	154-164	sterol 14-demethylase	Saccharomyces cerevisiae S288C	50-55
10722850-2	2000	Deletion of ERG4 resulted in a complete lack of ergosterol and accumulation of the precursor ergosta-5,7,22,24(28)-tetraen-3beta-ol.	Ergosterol	48-58	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	12-16
10620695-1	2000	The in vivo effects of CrCl(3) on an ergosterol-producing 33 erg(+) strain of the eukaryotic yeast Candida albicans, and on its ergosterol-deficient erg(-)2 mutant, were studied by using electron paramagnetic resonance spectroscopy.	Ergosterol	128-138	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	149-156
10719329-6	2000	Measurement of DHCR7 activity in CV cells was undertaken using ergosterol as a substrate.	Ergosterol	63-73	7-dehydrocholesterol reductase	Homo sapiens	15-20
10672016-10	2000	Lipid analysis of are1 and are2 deletion strains revealed that Are2p and Are1p utilize sterol substrates in vivo with different efficiency; Are2p has a significant preference for ergosterol as a substrate, whereas Are1p esterifies sterol precursors, mainly lanosterol, as well as ergosterol.	Ergosterol	280-290	sterol acyltransferase	Saccharomyces cerevisiae S288C	27-31
10672016-10	2000	Lipid analysis of are1 and are2 deletion strains revealed that Are2p and Are1p utilize sterol substrates in vivo with different efficiency; Are2p has a significant preference for ergosterol as a substrate, whereas Are1p esterifies sterol precursors, mainly lanosterol, as well as ergosterol.	Ergosterol	280-290	sterol acyltransferase	Saccharomyces cerevisiae S288C	63-68
10672016-10	2000	Lipid analysis of are1 and are2 deletion strains revealed that Are2p and Are1p utilize sterol substrates in vivo with different efficiency; Are2p has a significant preference for ergosterol as a substrate, whereas Are1p esterifies sterol precursors, mainly lanosterol, as well as ergosterol.	Ergosterol	280-290	sterol acyltransferase	Saccharomyces cerevisiae S288C	73-78
10672016-10	2000	Lipid analysis of are1 and are2 deletion strains revealed that Are2p and Are1p utilize sterol substrates in vivo with different efficiency; Are2p has a significant preference for ergosterol as a substrate, whereas Are1p esterifies sterol precursors, mainly lanosterol, as well as ergosterol.	Ergosterol	280-290	sterol acyltransferase	Saccharomyces cerevisiae S288C	140-145
10672016-13	2000	Nevertheless, terbinafine, an inhibitor of ergosterol biosynthesis, inhibits growth of are1are2 cells more efficiently than growth of wild-type.	Ergosterol	43-53	sterol acyltransferase	Saccharomyces cerevisiae S288C	87-95
10737174-5	2000	ERG6 encodes S-adenosylmethionine: delta 24-sterol-C-methyltransferase (EC 2.1.1.41) in the ergosterol synthetic pathway.	Ergosterol	92-102	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	0-4
10672016-10	2000	Lipid analysis of are1 and are2 deletion strains revealed that Are2p and Are1p utilize sterol substrates in vivo with different efficiency; Are2p has a significant preference for ergosterol as a substrate, whereas Are1p esterifies sterol precursors, mainly lanosterol, as well as ergosterol.	Ergosterol	179-189	sterol acyltransferase	Saccharomyces cerevisiae S288C	18-22
10672016-10	2000	Lipid analysis of are1 and are2 deletion strains revealed that Are2p and Are1p utilize sterol substrates in vivo with different efficiency; Are2p has a significant preference for ergosterol as a substrate, whereas Are1p esterifies sterol precursors, mainly lanosterol, as well as ergosterol.	Ergosterol	179-189	sterol acyltransferase	Saccharomyces cerevisiae S288C	27-31
10672016-10	2000	Lipid analysis of are1 and are2 deletion strains revealed that Are2p and Are1p utilize sterol substrates in vivo with different efficiency; Are2p has a significant preference for ergosterol as a substrate, whereas Are1p esterifies sterol precursors, mainly lanosterol, as well as ergosterol.	Ergosterol	179-189	sterol acyltransferase	Saccharomyces cerevisiae S288C	63-68
10672016-10	2000	Lipid analysis of are1 and are2 deletion strains revealed that Are2p and Are1p utilize sterol substrates in vivo with different efficiency; Are2p has a significant preference for ergosterol as a substrate, whereas Are1p esterifies sterol precursors, mainly lanosterol, as well as ergosterol.	Ergosterol	179-189	sterol acyltransferase	Saccharomyces cerevisiae S288C	73-78
10672016-10	2000	Lipid analysis of are1 and are2 deletion strains revealed that Are2p and Are1p utilize sterol substrates in vivo with different efficiency; Are2p has a significant preference for ergosterol as a substrate, whereas Are1p esterifies sterol precursors, mainly lanosterol, as well as ergosterol.	Ergosterol	179-189	sterol acyltransferase	Saccharomyces cerevisiae S288C	140-145
10620695-3	2000	The absence of ergosterol, an increased accumulation of Delta(8) sterols, a decreased fatty acid chainlength and a lower proportion of unsaturated fatty acids of the erg(-)2 mutant resulted in a higher membrane rigidity and an increased sensitivity to Cr(III) than those of the parental 33 erg(+) strain.	Ergosterol	15-25	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	166-173
10564282-2	1999	We isolated a mutant defective in the internalization step of endocytosis in a gene (ERG2) encoding a C-8 sterol isomerase that acts in the late part of the ergosterol biosynthetic pathway.	Ergosterol	157-167	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	85-89
10645622-3	1999	ARE2 overexpression had no impact on the accumulation of the early sterols such as lanosterol, but influenced the later intermediates and the end product ergosterol.	Ergosterol	154-164	sterol acyltransferase	Saccharomyces cerevisiae S288C	0-4
10373490-2	1999	Fen2p was postulated to act as a common regulator of carbon and nitrogen catabolite repression and of amino acid and ergosterol biosynthesis.	Ergosterol	117-127	Fen2p	Saccharomyces cerevisiae S288C	0-5
10433965-1	1999	The C-5 sterol desaturase gene (ERG3), essential for yeast ergosterol biosynthesis, was cloned and sequenced from Candida albicans by homology with the Saccharomyces cerevisiae ERG3.	Ergosterol	59-69	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	4-25
10433965-1	1999	The C-5 sterol desaturase gene (ERG3), essential for yeast ergosterol biosynthesis, was cloned and sequenced from Candida albicans by homology with the Saccharomyces cerevisiae ERG3.	Ergosterol	59-69	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	32-36
10433965-1	1999	The C-5 sterol desaturase gene (ERG3), essential for yeast ergosterol biosynthesis, was cloned and sequenced from Candida albicans by homology with the Saccharomyces cerevisiae ERG3.	Ergosterol	59-69	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	177-181
10433965-15	1999	Transformants with ERG3 from B311 but not from Dar-1 showed restored ergosterol synthesis.	Ergosterol	69-79	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	19-23
10535978-9	1999	Surprisingly, when erg27 was grown on cholesterol- or ergosterol-supplemented media, the endogenous compounds that accumulated were noncyclic sterol intermediates (squalene, squalene epoxide, and squalene dioxide), and there was little or no accumulation of lanosterol or 3-ketosterols.	Ergosterol	54-64	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	19-24
10514567-1	1999	Sequencing of the yeast gene that complemented the sensitivity to the photoactivated monofunctional 3-carbethoxypsoralen of the pso6-1 mutant strain revealed that the ERG3 locus, encoding sterol C-5 desaturase involved in biosynthesis of ergosterol, is allelic to PSO6.	Ergosterol	238-248	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	128-132
10514567-1	1999	Sequencing of the yeast gene that complemented the sensitivity to the photoactivated monofunctional 3-carbethoxypsoralen of the pso6-1 mutant strain revealed that the ERG3 locus, encoding sterol C-5 desaturase involved in biosynthesis of ergosterol, is allelic to PSO6.	Ergosterol	238-248	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	167-171
10514567-2	1999	Disruption of the ERG3 gene yielded an erg3Delta mutant viable in ergosterol-containing YEPD media with the same pleiotropic mutant phenotype known for pso6-1 and erg3 mutants, including sensitivity to hydrogen peroxide and paraquat.	Ergosterol	66-76	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	18-22
10514567-2	1999	Disruption of the ERG3 gene yielded an erg3Delta mutant viable in ergosterol-containing YEPD media with the same pleiotropic mutant phenotype known for pso6-1 and erg3 mutants, including sensitivity to hydrogen peroxide and paraquat.	Ergosterol	66-76	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	39-43
10514567-5	1999	Mutant pso6-1, with its lowered content of ergosterol, exhibited enhanced synthesis of chitin that was maldistributed and not confined to the bud scars.	Ergosterol	43-53	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	7-11
10336628-20	1999	CYP51 from wheat complemented the ERG11 disruption, as the modified yeasts did not need supplementation with exogenous ergosterol and grew normally under aerobic conditions.	Ergosterol	119-129	sterol 14-demethylase	Saccharomyces cerevisiae S288C	0-5
10336628-20	1999	CYP51 from wheat complemented the ERG11 disruption, as the modified yeasts did not need supplementation with exogenous ergosterol and grew normally under aerobic conditions.	Ergosterol	119-129	sterol 14-demethylase	Saccharomyces cerevisiae S288C	34-39
10220160-4	1999	To do this, the function of Pdr5p in isogenic strains of S. cerevisiae that have disruptions in the late stages of the ergosterol biosynthesis pathway (ERG6, ERG2, ERG3, ERG4) was studied.	Ergosterol	119-129	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	28-33
9742963-4	1998	Restoration of ergosterol synthesis, by introducing ERG9 functional allele into the deleted strain resulted in a significant lowering of polyprenol synthesis, indicating the immediate shift of the common substrate (FPP) to the sterol pathway.	Ergosterol	15-25	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	52-56
9972464-0	1998	Cytochrome P450 enzymes in the kidney of the bobwhite quail (Colinus virginianus): induction and inhibition by ergosterol biosynthesis inhibiting fungicides.	Ergosterol	111-121	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
9862498-5	1998	Transformed colonies were selected for restoration of C-8,7 sterol isomerase activity (i.e. wild-type ergosterol production) by enhanced resistance to the antibiotic cycloheximide.	Ergosterol	102-112	C-8,7 sterol isomerase	Arabidopsis thaliana	54-76
9862498-8	1998	The sigma ligands, haloperidol, ifenprodil and verapamil inhibited the production of ergosterol in wild-type Saccharomyces cerevisiae and in the erg2 mutant complemented with pA.t.SI1.	Ergosterol	85-95	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	145-149
9890948-3	1999	Deletion of PDR16 resulted in hypersensitivity of yeast to azole inhibitors of ergosterol biosynthesis.	Ergosterol	79-89	phosphatidylinositol transporter	Saccharomyces cerevisiae S288C	12-17
9890948-8	1999	The azole sensitivity of the PDR16-deleted strain may be the result of imbalanced ergosterol synthesis.	Ergosterol	82-92	phosphatidylinositol transporter	Saccharomyces cerevisiae S288C	29-34
9811880-7	1998	The YGL001c (ERG26) disruption also was viable in a hem 1Delta strain grown in the presence of ergosterol.	Ergosterol	95-105	sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)	Saccharomyces cerevisiae S288C	13-18
9811880-8	1998	Introduction of the erg26 mutation into an erg1 (squalene epoxidase) strain also was viable in ergosterol-supplemented media.	Ergosterol	95-105	sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)	Saccharomyces cerevisiae S288C	20-25
9811880-8	1998	Introduction of the erg26 mutation into an erg1 (squalene epoxidase) strain also was viable in ergosterol-supplemented media.	Ergosterol	95-105	squalene monooxygenase	Saccharomyces cerevisiae S288C	43-47
9713773-3	1998	In an attempt to develop antibodies for an immunoassay for ergosterol, we first derivatized the compound to its hemisuccinate (Erg-HS) and conjugated it to bovine serum albumin (Erg-HS-BSA).	Ergosterol	59-69	albumin	Oryctolagus cuniculus	163-176
9713773-3	1998	In an attempt to develop antibodies for an immunoassay for ergosterol, we first derivatized the compound to its hemisuccinate (Erg-HS) and conjugated it to bovine serum albumin (Erg-HS-BSA).	Ergosterol	59-69	transcriptional regulator ERG	Oryctolagus cuniculus	178-181
9186560-3	1997	Although the compounds inhibit squalene synthase, the first committed step in ergosterol biosynthesis, results presented in this paper show that inhibition of fungal growth is not related to inhibition of ergosterol synthesis.	Ergosterol	78-88	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	31-48
9661017-2	1998	Only a 4-fold decrease in ergosterol biosynthesis was observed for the cpr strain, but ketoconazole sensitivity increased 200-fold, indicating hypersensitivity to the alternative electron donor system in cpr strains.	Ergosterol	26-36	cytochrome p450 oxidoreductase	Homo sapiens	71-74
9661017-4	1998	The complementation of function was observed both in vitro and in vivo for the monoxygenases squalene epoxidase, CYP51, and CYP61 in the ergosterol biosynthesis pathway with which CPR is coupled.	Ergosterol	137-147	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	113-118
9661017-4	1998	The complementation of function was observed both in vitro and in vivo for the monoxygenases squalene epoxidase, CYP51, and CYP61 in the ergosterol biosynthesis pathway with which CPR is coupled.	Ergosterol	137-147	cytochrome p450 oxidoreductase	Homo sapiens	180-183
9468503-3	1998	This indicated availability of the CPR in each case to function with the monooxygenases squalene epoxidase, CYP51, and CYP61 in the ergosterol biosynthesis pathway.	Ergosterol	132-142	cytochrome p450 oxidoreductase	Homo sapiens	35-38
9468503-3	1998	This indicated availability of the CPR in each case to function with the monooxygenases squalene epoxidase, CYP51, and CYP61 in the ergosterol biosynthesis pathway.	Ergosterol	132-142	sterol 14-demethylase	Saccharomyces cerevisiae S288C	108-113
9468503-3	1998	This indicated availability of the CPR in each case to function with the monooxygenases squalene epoxidase, CYP51, and CYP61 in the ergosterol biosynthesis pathway.	Ergosterol	132-142	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	119-124
9468503-4	1998	Purification of the cytosolic mutant CPR indicated properties identical to native CPR and an ability to reconstitute ergosterol biosynthesis when added to a cell-free system, as well as to allow reconstitution of activity with purified CYP61, sterol 22-desaturase.	Ergosterol	117-127	cytochrome p450 oxidoreductase	Homo sapiens	37-40
9453158-5	1998	Efflux of beta-estradiol and corticosterone was inhibited by a 100-fold higher (200 nM) concentration of beta-estradiol, corticosterone, ergosterol or dexamethasone, but progesterone which could not be transported by Cdr1p did not affect the efflux and thus accumulation.	Ergosterol	137-147	cerebellar degeneration related protein 1	Homo sapiens	217-222
9290641-3	1997	When placed under GALA regulation, the Z. mays cDNA functionally complemented the erg6 mutation, restoring ergosterol production and conferring resistance to cycloheximide.	Ergosterol	107-117	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	82-86
18975152-2	1997	Not only ergosterol peroxide but also ergosterol showed very strong anticomplementary activity on the classical pathway, the IC(50) values being 5.0 muM and 1.0 muM, respectively.	Ergosterol	9-19	latexin	Homo sapiens	149-152
8988026-1	1996	The yeast gene ERG2 encodes a sterol C8-C7 isomerase and is essential for ergosterol synthesis and cell proliferation.	Ergosterol	74-84	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	15-19
8973183-10	1996	When isolated in the presence of detergent, all the variant Anc2p preparations contained ergosterol in similar amounts (9 mol/mol of 35 kDa Anc2p) but no specific interaction was revealed.	Ergosterol	89-99	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	60-65
8978840-3	1996	The delta 5-double bond appears to be required for the regulatory role of ergosterol; therefore, development of inhibitors of the enzyme that introduce this double bond, delta 7-sterol 5-desaturase (5-desaturase), may lead to effective antifungal agents.	Ergosterol	74-84	sterol-C5-desaturase	Homo sapiens	170-197
8772195-0	1996	Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway.	Ergosterol	112-122	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	64-68
8798656-8	1996	Human ACAT expressed in sat1 sat2 mutant cells can catalyze esterification of cholesterol and, to a lesser extent, ergosterol in vitro, but restores ergosteryl oleate formation in vivo to only approximately 8% of that catalyzed by yeast ASAT in wild-type cells.	Ergosterol	115-125	sterol O-acyltransferase 1	Homo sapiens	6-10
8798656-8	1996	Human ACAT expressed in sat1 sat2 mutant cells can catalyze esterification of cholesterol and, to a lesser extent, ergosterol in vitro, but restores ergosteryl oleate formation in vivo to only approximately 8% of that catalyzed by yeast ASAT in wild-type cells.	Ergosterol	115-125	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	24-28
8798656-8	1996	Human ACAT expressed in sat1 sat2 mutant cells can catalyze esterification of cholesterol and, to a lesser extent, ergosterol in vitro, but restores ergosteryl oleate formation in vivo to only approximately 8% of that catalyzed by yeast ASAT in wild-type cells.	Ergosterol	115-125	spermidine/spermine N1-acetyltransferase family member 2	Homo sapiens	29-33
8816455-7	1996	The absence of ergosterol resulted in a 35-fold increase in the expression of ERG3 as measured by beta-galactosidase activity.	Ergosterol	15-25	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	78-82
8816455-8	1996	The level of ERG3 mRNA was increased as much as ninefold in erg mutant strains or wild-type strains inhibited in ergosterol biosynthesis by antifungal agents.	Ergosterol	113-123	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	13-17
8816455-9	1996	The observed regulatory effects of ergosterol on ERG3 are specific for ergosterol, as several ergosterol derivatives failed to elicit the same controlling effect.	Ergosterol	35-45	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	49-53
8816455-9	1996	The observed regulatory effects of ergosterol on ERG3 are specific for ergosterol, as several ergosterol derivatives failed to elicit the same controlling effect.	Ergosterol	71-81	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	49-53
8816455-9	1996	The observed regulatory effects of ergosterol on ERG3 are specific for ergosterol, as several ergosterol derivatives failed to elicit the same controlling effect.	Ergosterol	71-81	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	49-53
8772195-4	1996	Likewise, mutations in non-auxotrophic ergosterol biosynthetic genes downstream of squalene production (erg2, erg3, erg4, erg5, and erg6) result in an up-regulation of ERG3 expression.	Ergosterol	39-49	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	104-108
8772195-4	1996	Likewise, mutations in non-auxotrophic ergosterol biosynthetic genes downstream of squalene production (erg2, erg3, erg4, erg5, and erg6) result in an up-regulation of ERG3 expression.	Ergosterol	39-49	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	110-114
8772195-4	1996	Likewise, mutations in non-auxotrophic ergosterol biosynthetic genes downstream of squalene production (erg2, erg3, erg4, erg5, and erg6) result in an up-regulation of ERG3 expression.	Ergosterol	39-49	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	116-120
8772195-4	1996	Likewise, mutations in non-auxotrophic ergosterol biosynthetic genes downstream of squalene production (erg2, erg3, erg4, erg5, and erg6) result in an up-regulation of ERG3 expression.	Ergosterol	39-49	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	122-126
8772195-4	1996	Likewise, mutations in non-auxotrophic ergosterol biosynthetic genes downstream of squalene production (erg2, erg3, erg4, erg5, and erg6) result in an up-regulation of ERG3 expression.	Ergosterol	39-49	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	132-136
8772195-4	1996	Likewise, mutations in non-auxotrophic ergosterol biosynthetic genes downstream of squalene production (erg2, erg3, erg4, erg5, and erg6) result in an up-regulation of ERG3 expression.	Ergosterol	39-49	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	168-172
8649379-4	1996	Cells growing anaerobically on ergosterol-containing medium are not sensitive to SR. Disruption of the sterol isomerase-encoding gene is lethal in cells growing in the absence of exogenous ergosterol, except in SR-resistant mutants lacking either the SUR4 or the FEN1 gene product.	Ergosterol	31-41	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	251-255
8649379-4	1996	Cells growing anaerobically on ergosterol-containing medium are not sensitive to SR. Disruption of the sterol isomerase-encoding gene is lethal in cells growing in the absence of exogenous ergosterol, except in SR-resistant mutants lacking either the SUR4 or the FEN1 gene product.	Ergosterol	31-41	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	263-267
8649379-5	1996	The results suggest that sterol isomerase is the target of SR 31747 and that both the SUR4 and FEN1 gene products are required to mediate the proliferation arrest induced by ergosterol depletion.	Ergosterol	174-184	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	86-90
8649379-5	1996	The results suggest that sterol isomerase is the target of SR 31747 and that both the SUR4 and FEN1 gene products are required to mediate the proliferation arrest induced by ergosterol depletion.	Ergosterol	174-184	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	95-99
8635732-0	1996	Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene, encoding a second cytochrome P-450 involved in ergosterol biosynthesis.	Ergosterol	137-147	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	61-83
8919915-1	1996	A yeast null mutant (erg 3) defective in ERG 3, the gene encoding the C-5 sterol desaturase required for ergosterol synthesis was transformed with an Arabidopsis thaliana cDNA library inserted in a yeast vector.	Ergosterol	105-115	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	21-26
8919915-1	1996	A yeast null mutant (erg 3) defective in ERG 3, the gene encoding the C-5 sterol desaturase required for ergosterol synthesis was transformed with an Arabidopsis thaliana cDNA library inserted in a yeast vector.	Ergosterol	105-115	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	41-46
8919915-1	1996	A yeast null mutant (erg 3) defective in ERG 3, the gene encoding the C-5 sterol desaturase required for ergosterol synthesis was transformed with an Arabidopsis thaliana cDNA library inserted in a yeast vector.	Ergosterol	105-115	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	70-91
8919915-5	1996	Transformation of an erg 3 strain with this plasmid led to CH resistance, nystatin sensitivity and an ergosterol profile.	Ergosterol	102-112	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	21-26
8771708-0	1996	FEN2: a gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast.	Ergosterol	76-86	Fen2p	Saccharomyces cerevisiae S288C	0-4
8771708-2	1996	fen2-1, that causes resistance to fenpropimorph and a low level of ergosterol in Saccharomyces cerevisiae.	Ergosterol	67-77	Fen2p	Saccharomyces cerevisiae S288C	0-4
8771716-1	1996	The ERG1 gene of Saccharomyces cerevisiae encodes squalene epoxidase, a key enzyme in the ergosterol pathway.	Ergosterol	90-100	squalene monooxygenase	Saccharomyces cerevisiae S288C	4-8
8771716-3	1996	Disruption of the gene with URA3 results in a lethal phenotype when cells are grown under aerobic conditions, even in the presence of ergosterol.	Ergosterol	134-144	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	28-32
8635732-0	1996	Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene, encoding a second cytochrome P-450 involved in ergosterol biosynthesis.	Ergosterol	137-147	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	108-124
8635732-2	1996	ERG5 is the putative gene encoding the C-22 sterol desaturase required in ergosterol biosynthesis.	Ergosterol	74-84	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	0-4
8635732-2	1996	ERG5 is the putative gene encoding the C-22 sterol desaturase required in ergosterol biosynthesis.	Ergosterol	74-84	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	39-61
12232266-9	1994	In contrast to the specificity with regard to the glycosyl donor, UDPG-SGTase utilized all tested sterol acceptors, such as [beta]-sitosterol, cholesterol, stigmasterol, and ergosterol.	Ergosterol	174-184	UDP-glucose pyrophosphorylase 2	Homo sapiens	66-70
8552601-3	1996	An ergosterol auxotroph, erg25, which fails to demethylate and concomitantly accumulates 4,4-dimethylzy-mosterol, was isolated after mutagenesis.	Ergosterol	3-13	methylsterol monooxygenase	Saccharomyces cerevisiae S288C	25-30
7645344-8	1995	The third complementation group was found to be the ERG6 gene, previously suggested to encode the ergosterol biosynthetic enzyme sterol methyltransferase.	Ergosterol	98-108	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	52-56
7645344-10	1995	Mutation of ERG3, encoding another ergosterol biosynthetic enzyme, also caused Nal sensitivity, suggesting that plasma membrane sterol composition, and plasma membrane function, mediates recovery from Nal-mediated inhibition of Start.	Ergosterol	35-45	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	12-16
7766188-0	1995	The physiological roles of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae.	Ergosterol	36-46	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	80-84
7766188-0	1995	The physiological roles of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae.	Ergosterol	36-46	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	85-89
7766188-2	1995	The effects of disrupting the Saccharomyces cerevisiae SYR1/ERG3 gene, which encodes sterol C-5 desaturase, an enzyme of ergosterol biosynthesis pathway, were markedly different for different S. cerevisiae strains and growth temperatures.	Ergosterol	121-131	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	55-59
7766188-2	1995	The effects of disrupting the Saccharomyces cerevisiae SYR1/ERG3 gene, which encodes sterol C-5 desaturase, an enzyme of ergosterol biosynthesis pathway, were markedly different for different S. cerevisiae strains and growth temperatures.	Ergosterol	121-131	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	60-64
7766188-5	1995	Moreover, the growth of the delta syr1 disruptant of W303-1A and KA-311A strains were severely inhibited at 16 degrees C. These results indicated that ergosterol is essential for growth at low temperatures, and the effects of the gene disruption are variable by the genetic background.	Ergosterol	151-161	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	34-38
7766188-7	1995	The delta syr1 mutants were sensitive to a wide variety of drugs, chemicals, and ions, suggesting that yeast ergosterol is important as permeability barrier against various chemical stresses.	Ergosterol	109-119	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	10-14
7489925-1	1995	A new gene (SUT1) of Saccharomyces cerevisiae, implicated in sterol uptake, was isolated from a yeast genomic library constructed in a high-copy-number vector by virtue of conferring resistance to fenpropimorph in medium supplemented with ergosterol.	Ergosterol	239-249	Sut1p	Saccharomyces cerevisiae S288C	12-16
7548216-6	1995	Mutants for SUR4 and FEN1 have the same pleiotropic phenotype, including bud localization defects, resistance to an immunosuppressor and resistance to ergosterol biosynthesis inhibitors.	Ergosterol	151-161	fatty acid elongase ELO3	Saccharomyces cerevisiae S288C	12-16
7548216-6	1995	Mutants for SUR4 and FEN1 have the same pleiotropic phenotype, including bud localization defects, resistance to an immunosuppressor and resistance to ergosterol biosynthesis inhibitors.	Ergosterol	151-161	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	21-25
7765777-2	1994	To obtain a stable squalene-accumulating yeast strain, we attempted to disrupt a gene required in the conversion of squalene to ergosterol, by homologous recombination with a short piece of the gene fragment conjugated with an integration plasmid vector carrying the LEU2 gene.	Ergosterol	128-138	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	267-271
8125337-10	1994	Analyses of these genes demonstrated that strains carrying disruptions of sts1+ or YGL022 have ergosterol biosynthesis defects in the enzyme, sterol C-24(28) reductase (Erg4p; encoded by ERG4).	Ergosterol	95-105	Sts1p	Saccharomyces cerevisiae S288C	74-78
8038180-8	1994	Data base searches indicate that LIS1 is identical to ERG6 in S. cerevisiae which encodes a putative S-adenosylmethionine-dependent methyltransferase in the ergosterol biosynthetic pathway.	Ergosterol	157-167	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	33-37
8038180-8	1994	Data base searches indicate that LIS1 is identical to ERG6 in S. cerevisiae which encodes a putative S-adenosylmethionine-dependent methyltransferase in the ergosterol biosynthetic pathway.	Ergosterol	157-167	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	54-58
8038180-9	1994	Cell membranes of lis1 (erg6) mutants are known to be devoid of ergosterol and have altered sterol composition.	Ergosterol	64-74	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	18-22
8038180-9	1994	Cell membranes of lis1 (erg6) mutants are known to be devoid of ergosterol and have altered sterol composition.	Ergosterol	64-74	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	24-28
8125337-10	1994	Analyses of these genes demonstrated that strains carrying disruptions of sts1+ or YGL022 have ergosterol biosynthesis defects in the enzyme, sterol C-24(28) reductase (Erg4p; encoded by ERG4).	Ergosterol	95-105	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	169-174
8125337-10	1994	Analyses of these genes demonstrated that strains carrying disruptions of sts1+ or YGL022 have ergosterol biosynthesis defects in the enzyme, sterol C-24(28) reductase (Erg4p; encoded by ERG4).	Ergosterol	95-105	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	187-191
8017104-0	1994	A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein.	Ergosterol	42-52	oxysterol binding protein	Homo sapiens	87-112
8017104-6	1994	Our study implicates this new yeast gene family in ergosterol synthesis and provides comparative evidence of a role for human OSBP in cholesterol synthesis.	Ergosterol	51-61	oxysterol binding protein	Homo sapiens	126-130
8180700-0	1994	Identification and analysis of the Saccharomyces cerevisiae SYR1 gene reveals that ergosterol is involved in the action of syringomycin.	Ergosterol	83-93	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	60-64
8180700-4	1994	SYR1 was identical to ERG3, which is suggested to encode C-5 sterol desaturase required for ergosterol biosynthesis.	Ergosterol	92-102	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	0-4
8180700-4	1994	SYR1 was identical to ERG3, which is suggested to encode C-5 sterol desaturase required for ergosterol biosynthesis.	Ergosterol	92-102	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	22-26
8180700-4	1994	SYR1 was identical to ERG3, which is suggested to encode C-5 sterol desaturase required for ergosterol biosynthesis.	Ergosterol	92-102	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	57-78
8203167-0	1994	SED6 is identical to ERG6, and encodes a putative methyltransferase required for ergosterol synthesis.	Ergosterol	81-91	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	0-4
8203167-0	1994	SED6 is identical to ERG6, and encodes a putative methyltransferase required for ergosterol synthesis.	Ergosterol	81-91	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	21-25
8109167-1	1993	ERG3 is the structural gene in Saccharomyces cerevisiae for the sterol delta 5 desaturase that introduces the C5 = 6 unsaturation in ergosterol biosynthesis.	Ergosterol	133-143	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	0-4
8246690-2	1993	Among the mutants isolated, one bearing the recessive fen1-1 mutation was characterized by a 1.5-fold increase in the ergosterol level and a general resistance to sterol biosynthesis inhibitors.	Ergosterol	118-128	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	54-58
8246690-6	1993	The fen1-1 mutation permits viability in aerobiosis of yeast disrupted for sterol-14 reductase in absence of exogenous ergosterol supplementation, whereas the corresponding strain bearing the wild type FEN1 allele grows only in anaerobiosis.	Ergosterol	119-129	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	4-8
8246690-7	1993	This result shows that ignosterol is able to efficiently replace ergosterol as bulk membrane component and that the fen1-1 mutation eliminates the specific ergosterol requirement in yeast.	Ergosterol	156-166	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	116-120
8474436-7	1993	Expression of cDNA clones encoding S. pombe or hybrid human-S. cerevisiae squalene synthetases reversed the ergosterol requirement of S. cerevisiae cells bearing ERG9 gene disruptions, showing that these enzymes can functionally replace the S. cerevisiae enzyme.	Ergosterol	108-118	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	162-166
7690968-6	1993	Vitamin D2 and 1 alpha-hydroxyvitamin D2, both with the ergosterol-like side chain, were 24- and 26(27)-hydroxylated by CYP27.	Ergosterol	56-66	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	120-125
1730736-1	1992	The major cytochrome P450 in the yeast Saccharomyces cerevisiae, lanosterol 14 alpha-demethylase (ERG11), catalyzes an essential reaction in the biosynthesis of ergosterol, the predominant sterol of yeast.	Ergosterol	161-171	sterol 14-demethylase	Saccharomyces cerevisiae S288C	98-103
1423890-2	1992	A cytochrome P450 gene has been well characterized in this yeast: CYP51, which codes for a constitutive enzyme involved in the 14 alpha-demethylation of lanosterol, a key step in the biosynthesis of ergosterol.	Ergosterol	199-209	sterol 14-demethylase	Saccharomyces cerevisiae S288C	66-71
1429452-3	1992	Our results demonstrate that palmitoleic acid (16:1) acts as a rate-limiting positive regulator and that ergosterol acts as a potent inhibitor of sterol production in strains which possess only the HMGR1 isozyme (HMG1 hmg2).	Ergosterol	105-115	hydroxymethylglutaryl-CoA reductase (NADPH) HMG1	Saccharomyces cerevisiae S288C	213-217
1429452-3	1992	Our results demonstrate that palmitoleic acid (16:1) acts as a rate-limiting positive regulator and that ergosterol acts as a potent inhibitor of sterol production in strains which possess only the HMGR1 isozyme (HMG1 hmg2).	Ergosterol	105-115	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	218-222
1429452-4	1992	In strains which contain only the HMGR2 isozyme (hmg1 HMG2), sterol production was inhibited by oleic acid (18:1) and to a lesser degree by ergosterol.	Ergosterol	140-150	hydroxymethylglutaryl-CoA reductase (NADPH) HMG1	Saccharomyces cerevisiae S288C	49-53
1429452-4	1992	In strains which contain only the HMGR2 isozyme (hmg1 HMG2), sterol production was inhibited by oleic acid (18:1) and to a lesser degree by ergosterol.	Ergosterol	140-150	hydroxymethylglutaryl-CoA reductase (NADPH) HMG2	Saccharomyces cerevisiae S288C	54-58
1779709-3	1991	The complementing region of DNA required to restore ergosterol synthesis to erg2 was limited to a 1.0 kb StuI-BglII fragment.	Ergosterol	52-62	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	76-80
24194343-2	1991	A 25-cm Li-Chrosphere RP18 HPLC column gave excellent resolution of ergosterol in leaf extracts.	Ergosterol	68-78	pre-mRNA processing factor 3	Homo sapiens	22-26
1779710-4	1991	The isolation of the functional ERG20 gene allowed us to show that farnesyl diphosphate synthetase could be a rate limiting enzyme in ergosterol biosynthesis in yeast.	Ergosterol	134-144	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	32-37
34935446-0	2021	Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2ADelta Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis.	Ergosterol	162-172	Rox1p	Saccharomyces cerevisiae S288C	17-21
1864507-2	1991	ERG3 is the putative gene encoding the C-5 sterol desaturase required for ergosterol biosynthesis.	Ergosterol	74-84	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	0-4
1864507-2	1991	ERG3 is the putative gene encoding the C-5 sterol desaturase required for ergosterol biosynthesis.	Ergosterol	74-84	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	39-60
2185141-8	1990	The level of OSC produced from expression of a single copy of the Candida ERG7 sequence was sufficient to allow growth of the S. cerevisiae erg7 mutants in the absence of exogenous ergosterol.	Ergosterol	181-191	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	74-78
2091733-2	1990	Currently, representatives of two classes of EBI antifungals are available: the squalene epoxidase inhibitors and those that interfere with cytochrome P450-dependent ergosterol synthesis.	Ergosterol	166-176	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	151-155
2091733-8	1990	All the azole antifungals inhibit the cytochrome P450-dependent, 14 alpha-demethylase, a key enzyme in the synthesis of ergosterol, the main sterol in most fungal cells.	Ergosterol	120-130	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	49-53
2260347-2	1990	Its mechanism of action, like that of other azoles, involves interruption of the conversion of lanosterol to ergosterol via binding to fungal cytochrome P-450 and subsequent disruption of fungal membranes.	Ergosterol	109-119	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	142-158
19416366-4	2009	The budding yeast contains two other paralogs, Ylr046p, of unknown function, and Rta1p, overexpression of which confers resistance to an ergosterol biosynthesis inhibitor.	Ergosterol	137-147	Rta1p	Saccharomyces cerevisiae S288C	81-86
34772530-2	2022	In the study, we selected the key ergosterol bio-synthetic enzymes (Squalene epoxidase, SE; 14 alpha-demethylase, CYP51) as dual-target receptors to guide the construction of novel antifungal compounds, which could achieve the purpose of improving drug efficacy and reducing drug-resistance.	Ergosterol	34-44	cytochrome P450, family 51	Mus musculus	114-119
34772530-7	2022	Preliminary mechanism study revealed the compounds (14a-2, 20b-2) could block the bio-synthetic pathway of ergosterol by inhibiting the dual-target (SE/CYP51) activity, and this finally caused the cleavage and death of fungal cells.	Ergosterol	107-117	cytochrome P450, family 51	Mus musculus	152-157
34731761-1	2022	Ergosterol exert the important function in maintaining the fluidity and osmotic pressure of fungal cells, and its key biosynthesis enzymes (Squalene epoxidase, SE; 14 alpha-demethylase, CYP51) displayed the obvious synergistic effects.	Ergosterol	0-10	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	186-191
34731761-7	2022	Preliminary mechanism studies have confirmed that these compounds effectively inhibited the dual-target (SE/CYP51) activity, they could cause fungal rupture and death by blocking the bio-synthetic pathway of ergosterol.	Ergosterol	208-218	squalene epoxidase	Homo sapiens	105-107
34731761-7	2022	Preliminary mechanism studies have confirmed that these compounds effectively inhibited the dual-target (SE/CYP51) activity, they could cause fungal rupture and death by blocking the bio-synthetic pathway of ergosterol.	Ergosterol	208-218	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	108-113
34935446-6	2021	In the presence of fluconazole, loss of Rox1 function restores ERG11 expression to the upc2ADelta mutant and inhibits the expression of ERG3 and ERG6, leading to increased levels of ergosterol and decreased levels of the toxic sterol 14alpha methyl-ergosta-8,24(28)-dien-3beta, 6alpha-diol, relative to the upc2ADelta mutant.	Ergosterol	182-192	Rox1p	Saccharomyces cerevisiae S288C	40-44
34827708-3	2021	In this study, we engineered the biosynthesis of 24-methylene-cholesterol in Saccharomyces cerevisiae by disrupting the two enzymes (i.e., ERG4 and ERG5) in the yeast"s native ergosterol pathway, with ERG5 being replaced with the DHCR7 (7-dehydrocholesterol reductase) enzyme.	Ergosterol	176-186	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	139-143
34885791-11	2021	Analysis of sterol patterns after incubation gave valuable insights into the putative molecular mechanism of action, indicating inhibition of the enzymes sterol C14-reductase and sterol C8-isomerase in fungal ergosterol biosynthesis.	Ergosterol	209-219	transmembrane 7 superfamily member 2	Homo sapiens	154-174
34827708-3	2021	In this study, we engineered the biosynthesis of 24-methylene-cholesterol in Saccharomyces cerevisiae by disrupting the two enzymes (i.e., ERG4 and ERG5) in the yeast"s native ergosterol pathway, with ERG5 being replaced with the DHCR7 (7-dehydrocholesterol reductase) enzyme.	Ergosterol	176-186	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	148-152
34098080-5	2021	To initially screen the ability of these metabolites to interact with the active site of DHCR7, their ability to inhibit the conversion of ergosterol to brassicasterol was measured.	Ergosterol	139-149	7-dehydrocholesterol reductase	Rattus norvegicus	89-94
34591857-4	2021	In other Candida species, mutant forms of a transcription factor called Upc2 are associated with azole resistance, owing to the important role of this protein in control of expression of genes encoding enzymes involved in the ergosterol biosynthetic pathway.	Ergosterol	226-236	Upc2p	Saccharomyces cerevisiae S288C	72-76
34739144-6	2022	Overall, the results are of interest since they show that MMPL-family proteins are present in essentially all life-forms: archaea, bacteria, protozoa, fungi, plants and animals and, where known, they are involved in "lipid" (glycolipid, phospholipid, sphingolipid, fatty acid, cholesterol, ergosterol) transport, powered by transmembrane molecular pumps having similar structures.	Ergosterol	290-300	proteolipid protein 1	Homo sapiens	58-62
34495682-5	2021	These lipids plus ergosterol also allow full trans-SNARE complex assembly, yet do not support fusion, which is reliant on either phosphatidylethanolamine (PE) or on phosphatidic acid (PA), phosphatidylserine (PS), and diacylglycerol (DAG).	Ergosterol	18-28	small NF90 (ILF3) associated RNA E	Homo sapiens	51-56
34098080-7	2021	Sterols that inhibited ergosterol reduction were directly tested as substrates for DHCR7.	Ergosterol	23-33	7-dehydrocholesterol reductase	Rattus norvegicus	83-88
34098080-10	2021	The resistance of lumisterol and 7DHP to reduction by DHCR7 in cells will permit other enzymes to metabolise these sterols to their active forms retaining the C7-C8 double bond, conferring specificity to their biological actions.	Ergosterol	18-28	7-dehydrocholesterol reductase	Rattus norvegicus	54-59
35587358-2	2022	Here, we reveal perturbed ergosterol production in  get3 cells and demonstrate the sensitivity of GET pathway mutants to the sterol synthesis inhibiting drug terbinafine.	Ergosterol	26-36	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	52-56
34268298-4	2021	Then, the push and pull of ergosterol biosynthesis were engineered to increase the metabolic flux, overexpression of the sterol acyltransferase gene ARE2 increased ergosterol content to 10 mg/g DCW and additional overexpression of a global regulatory factor allele (UPC2-1) increased the ergosterol content to 16.7 mg/g DCW.	Ergosterol	164-174	sterol acyltransferase	Saccharomyces cerevisiae S288C	149-153
34268298-7	2021	To address growth inhibition resulted from premature accumulation of ergosterol, auto-inducible promoters were employed to dynamically control the expression of ARE2, UPC2-1, and ACC1.	Ergosterol	69-79	sterol acyltransferase	Saccharomyces cerevisiae S288C	161-165
35120994-8	2022	We propose that Dap1 regulates the synthesis of astaxanthin and ergosterol in X. dendrorhous, probably by regulating the P450s involved in both biosynthetic pathways at the protein level.	Ergosterol	64-74	Dap1p	Saccharomyces cerevisiae S288C	16-20
35606304-3	2022	In this study, we described expression control of squalene monooxygenase (Erg1p), the first-step enzyme of ergosterol synthesis from squalene, to significantly reduce squalene loss.	Ergosterol	107-117	squalene monooxygenase	Saccharomyces cerevisiae S288C	74-79
35357135-8	2022	Molecular simulation docking results of compound D26 and difenoconazole with fungal CYP51 P450 confirmed that they both inhibit this enzyme involved in ergosterol biosynthesis.	Ergosterol	152-162	CYTOCHROME P450 51G1	Arabidopsis thaliana	84-89
35025137-9	2022	Anu taila downregulated sterol-C5-desaturase-coding ERG3 gene, crucial for ergosterol biosynthesis and resultant structural integrity, in Mucor spp.	Ergosterol	75-85	sterol-C5-desaturase	Homo sapiens	24-44
35025137-9	2022	Anu taila downregulated sterol-C5-desaturase-coding ERG3 gene, crucial for ergosterol biosynthesis and resultant structural integrity, in Mucor spp.	Ergosterol	75-85	sterol-C5-desaturase	Homo sapiens	52-56
35194654-6	2022	The overexpression of ELM1 increased the accumulation of trehalose and ergosterol and altered the composition of fatty acids with altered gene expressions involved in the metabolism of three metabolites.	Ergosterol	71-81	serine/threonine protein kinase ELM1	Saccharomyces cerevisiae S288C	22-26
35194654-7	2022	Enhanced resistance to heat shock stress in SAK1 overexpression might be related to the enhanced accumulation of trehalose and ergosterol and upregulated transcription of genes related to the metabolism of trehalose and ergosterol.	Ergosterol	127-137	serine/threonine protein kinase SAK1	Saccharomyces cerevisiae S288C	44-48
35194654-7	2022	Enhanced resistance to heat shock stress in SAK1 overexpression might be related to the enhanced accumulation of trehalose and ergosterol and upregulated transcription of genes related to the metabolism of trehalose and ergosterol.	Ergosterol	220-230	serine/threonine protein kinase SAK1	Saccharomyces cerevisiae S288C	44-48
35194654-8	2022	Furthermore, Elm1 might regulate the metabolism of trehalose, ergosterol, and fatty acids in a Snf1-independent form under high-glucose stress.	Ergosterol	62-72	serine/threonine protein kinase ELM1	Saccharomyces cerevisiae S288C	13-17
35194654-10	2022	However, Sak1 and Snf1 may have an indirect relationship in the regulation of ergosterol synthesis.	Ergosterol	78-88	serine/threonine protein kinase SAK1	Saccharomyces cerevisiae S288C	9-13
35584803-4	2022	Whole-genome sequencing of independent diazaborine-resistant lineages identified a recurring mutation in ERG25, which encodes a C-4 methyl sterol oxidase required for ergosterol biosynthesis in fungi.	Ergosterol	167-177	methylsterol monooxygenase	Saccharomyces cerevisiae S288C	105-110
35471041-0	2022	The Set1 Histone H3K4 Methyltransferase Contributes to Azole Susceptibility in a Species-Specific Manner by Differentially Altering the Expression of Drug Efflux Pumps and the Ergosterol Gene Pathway.	Ergosterol	176-186	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	4-8
35471041-9	2022	However, RNA sequencing revealed that C. glabrata Set1 is necessary for azole-induced expression of all 12 genes in the late ergosterol biosynthesis pathway, including ERG11 and ERG3.	Ergosterol	125-135	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	50-54
35471041-9	2022	However, RNA sequencing revealed that C. glabrata Set1 is necessary for azole-induced expression of all 12 genes in the late ergosterol biosynthesis pathway, including ERG11 and ERG3.	Ergosterol	125-135	sterol 14-demethylase	Saccharomyces cerevisiae S288C	168-173
35471041-11	2022	In addition, high performance liquid chromatography analysis indicated Set1 is necessary for maintaining proper ergosterol levels under azole treatment.	Ergosterol	112-122	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	71-75
35399500-4	2022	Based on the screening of C. glabrata conditional knockdown mutants for each gene involved in ergosterol biosynthesis, ERG25 knockdown was found to decrease lethality of infected mice.	Ergosterol	94-104	methylsterol monoxygenase 1	Mus musculus	119-124
35399500-6	2022	ERG25 knockdown further influences the structure of the membrane compartment of Can1p (MCC)/eisosomes (ergosterol-rich lipid domains), but not the localization of the membrane proteins Pma1p and Hxt1p, which localize to sterol-poor domains.	Ergosterol	103-113	methylsterol monoxygenase 1	Mus musculus	0-5
35065996-0	2022	Ergosterol Analogs as Inhibitors of Cyclin Dependent Kinase 8.	Ergosterol	0-10	cyclin dependent kinase 8	Homo sapiens	36-61
35065996-1	2022	Five new compounds based on the structure of ergosterol have been prepared and tested for their ability to inhibit CDK8.	Ergosterol	45-55	cyclin dependent kinase 8	Homo sapiens	115-119
35205858-0	2022	Crosstalk between Yeast Cell Plasma Membrane Ergosterol Content and Cell Wall Stiffness under Acetic Acid Stress Involving Pdr18.	Ergosterol	45-55	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	123-128
35040997-8	2022	In agreement, Zap1-depleted cells present, in addition to decreased ergosterol levels, an altered composition of membrane phospholipids, which together should impact membrane function and impair the detoxification of fluconazole.	Ergosterol	68-78	Zap1p	Saccharomyces cerevisiae S288C	14-18
35205858-3	2022	Pdr18 is a plasma membrane ABC transporter of the pleiotropic drug resistance family and a reported determinant of acetic acid tolerance mediating ergosterol transport.	Ergosterol	147-157	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	0-5
3050008-2	1988	In each case the mutation is nuclear in origin and allelic to a previously described mutation, erg3, which gives rise to a block in the delta 5-6 desaturation step of ergosterol biosynthesis.	Ergosterol	167-177	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	95-99
35050009-1	2022	The fungal cytochrome P450 lanosterol 14alpha-demethylase (CYP51) is required for the biosynthesis of fungal-specific ergosterol and is the target of azole antifungal drugs.	Ergosterol	118-128	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	59-64
2497796-1	1989	From permeability experiments carried out with series of amphotericin B derivatives in both biological and model membranes, it was concluded that derivatives, whose carboxyl group at the C18 position is blocked by substitution, are much more efficient at inducing permeability in ergosterol-containing than in cholesterol-containing membranes, whereas derivatives whose carboxyl group is free and ionizable are equally efficient in both membranes types.	Ergosterol	280-290	Bardet-Biedl syndrome 9	Homo sapiens	187-190
727219-3	1978	The most resistant isolate (R-2) lacked cell membrane ergosterol, the usual attachment site for amphotericin B, and was not inhibited by greater than 500 micrograms/ml of the drug.	Ergosterol	54-64	CD1e molecule	Homo sapiens	28-31
6523807-4	1984	The products of a possible ergosterol transformation (dehydroneoergosterol-24-methyl-1,3,5 (10), 6,8 (9), 22-hexaen-3 beta-ol; 24-methylcholesta-7,24 (28)-dien-3 beta-ol; 4-cholesta-7,22,25 (?	Ergosterol	27-37	integrin subunit beta 1	Rattus norvegicus	118-125
6523807-4	1984	The products of a possible ergosterol transformation (dehydroneoergosterol-24-methyl-1,3,5 (10), 6,8 (9), 22-hexaen-3 beta-ol; 24-methylcholesta-7,24 (28)-dien-3 beta-ol; 4-cholesta-7,22,25 (?	Ergosterol	27-37	integrin subunit beta 1	Rattus norvegicus	162-169
3288361-4	1988	The oxidative metabolism of lanosterol, that is included in the biosynthetic pathway of ergosterol, is one of the important functions of the microsomal electron transport system, which is catalyzed by P450(14DM).	Ergosterol	88-98	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	201-210
33905080-2	2021	In this study, we identified the bioactive compounds ergosterol peroxide (EPO) and ergosterol (ERG) from the MeOH extract of O. gracilioides mycelia related to its anti-cancer effects by targeting the Nuclear Factor kappa B (NF-kB)/Signal Transducer and Activator of Transcription 3 (STAT3) inflammatory pathways.	Ergosterol	53-63	signal transducer and activator of transcription 3	Mus musculus	284-289
323256-8	1977	Mutants in hem1, hem2, and hem3 had an additional requirement for methionine on synthetic medium supplemented with either heme or ergosterol and Tween 80, owing to a lack of sulfite reductase which contains siroheme, a modified uroporphyrin III.	Ergosterol	130-140	5-aminolevulinate synthase	Saccharomyces cerevisiae S288C	11-15
323256-8	1977	Mutants in hem1, hem2, and hem3 had an additional requirement for methionine on synthetic medium supplemented with either heme or ergosterol and Tween 80, owing to a lack of sulfite reductase which contains siroheme, a modified uroporphyrin III.	Ergosterol	130-140	porphobilinogen synthase HEM2	Saccharomyces cerevisiae S288C	17-21
323256-8	1977	Mutants in hem1, hem2, and hem3 had an additional requirement for methionine on synthetic medium supplemented with either heme or ergosterol and Tween 80, owing to a lack of sulfite reductase which contains siroheme, a modified uroporphyrin III.	Ergosterol	130-140	hydroxymethylbilane synthase	Saccharomyces cerevisiae S288C	27-31
33651333-6	2021	The antifungals acted on the ergosterol biosynthesis pathway, and two homologous genes coding for cytochrome P450 51 enzymes were upregulated.	Ergosterol	29-39	cytochrome P450 51	Purpureocillium lilacinum	98-116
34038161-0	2021	Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane.	Ergosterol	67-77	Sfk1p	Saccharomyces cerevisiae S288C	27-31
34038161-9	2021	We propose that ergosterol is retained in the PM by the asymmetrical distribution of phospholipids and the action of Sfk1.	Ergosterol	16-26	Sfk1p	Saccharomyces cerevisiae S288C	117-121
33713678-1	2021	Aminoacylated ergosterol such as 1-ergosteryl aspartate (Erg-Asp) is a new lipid component recently discovered in fungi.	Ergosterol	14-24	ETS transcription factor ERG	Homo sapiens	57-60
33713678-3	2021	Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids.	Ergosterol	79-90	ETS transcription factor ERG	Homo sapiens	92-95
33713678-3	2021	Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids.	Ergosterol	79-90	ETS transcription factor ERG	Homo sapiens	92-95
33713678-3	2021	Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids.	Ergosterol	79-90	ETS transcription factor ERG	Homo sapiens	92-95
33713678-3	2021	Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids.	Ergosterol	79-90	ETS transcription factor ERG	Homo sapiens	92-95
33713678-3	2021	Herein, we report the synthesis of Erg-Asp as well as some other aminoacylated ergosterols (Erg-Gly, Erg-Ala, Erg-Leu, Erg-Ile, and Erg-Val) using Boc protected amino acids.	Ergosterol	79-90	ETS transcription factor ERG	Homo sapiens	92-95
331007-1	1977	The sterols accumulated by ergosterol deficient mutants of the genes erg6, erg2, erg3, and erg5 (formerly po11, po12, po13, and po15) have been analyzed by gas liquid chromatography.	Ergosterol	27-37	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	69-73
331007-1	1977	The sterols accumulated by ergosterol deficient mutants of the genes erg6, erg2, erg3, and erg5 (formerly po11, po12, po13, and po15) have been analyzed by gas liquid chromatography.	Ergosterol	27-37	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	75-79
331007-1	1977	The sterols accumulated by ergosterol deficient mutants of the genes erg6, erg2, erg3, and erg5 (formerly po11, po12, po13, and po15) have been analyzed by gas liquid chromatography.	Ergosterol	27-37	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	81-85
331007-1	1977	The sterols accumulated by ergosterol deficient mutants of the genes erg6, erg2, erg3, and erg5 (formerly po11, po12, po13, and po15) have been analyzed by gas liquid chromatography.	Ergosterol	27-37	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	91-95
5419748-0	1970	The stereochemistry of hydrogen elimination from C-7 in cholesterol and ergosterol biosynthesis.	Ergosterol	72-82	complement C7	Rattus norvegicus	49-52
33716049-6	2021	Indeed, CYP11A1 plays several critical roles in the skin through its initiation of local steroidogenesis and specific metabolism of vitamin D, lumisterol, and 7-dehydrocholesterol.	Ergosterol	143-153	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	8-15
34011234-2	2021	The mechanism of action of the drug consisting in inhibits sterol 14alpha-demethylase which interferes with ergosterol biosynthesis.	Ergosterol	108-118	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	59-85
33905080-2	2021	In this study, we identified the bioactive compounds ergosterol peroxide (EPO) and ergosterol (ERG) from the MeOH extract of O. gracilioides mycelia related to its anti-cancer effects by targeting the Nuclear Factor kappa B (NF-kB)/Signal Transducer and Activator of Transcription 3 (STAT3) inflammatory pathways.	Ergosterol	95-98	signal transducer and activator of transcription 3	Mus musculus	284-289
33524398-7	2021	Further genetic and biochemical analysis indicated that Ubp3 enhances the proteasome"s ability to degrade the ergosterol biosynthetic enzymes Erg1 and Erg3.	Ergosterol	110-120	squalene monooxygenase	Saccharomyces cerevisiae S288C	142-146
33676184-8	2021	The results of the ergosterol assay, confocal microscopy and FE-SEM studies indicated that invasion to cell wall and membrane components were the main antifungal mechanisms of CMt1 peptide.	Ergosterol	19-29	myelin protein zero	Homo sapiens	176-180
33713347-8	2021	The presence of CAS1, CPI1, and HYD1 in the four algal genomes suggests the higher plant cycloartenol branch for sterol biosynthesis, confirming that algae and fungi use different pathways for ergosterol synthesis.	Ergosterol	193-203	cycloartenol synthase 1	Arabidopsis thaliana	16-20
33713347-10	2021	With regards to why C. subellipsoidea produced phytosterols instead of ergosterol, we identified 22 differentially conserved positions where C. subellipsoidea CAS and A. thaliana CAS1 have one amino acid while the three ergosterol producing algae have another.	Ergosterol	71-81	cycloartenol synthase 1	Arabidopsis thaliana	179-183
33488803-0	2021	Ergosterol limits osteoarthritis development and progression through activation of Nrf2 signaling.	Ergosterol	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
33488803-4	2021	Ergosterol (ER), which is extracted from fungi, is a newly discovered Nrf2 activator and displayed efficacy against myocardial injury.	Ergosterol	0-10	epiregulin	Homo sapiens	12-14
33488803-4	2021	Ergosterol (ER), which is extracted from fungi, is a newly discovered Nrf2 activator and displayed efficacy against myocardial injury.	Ergosterol	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	70-74
33524398-6	2021	Deep-coverage quantitative proteomics reveals that ergosterol biosynthesis is rerouted into a sterol pathway that generates toxic products in the absence of Ubp3.	Ergosterol	51-61	mRNA-binding ubiquitin-specific protease UBP3	Saccharomyces cerevisiae S288C	157-161
33524398-7	2021	Further genetic and biochemical analysis indicated that Ubp3 enhances the proteasome"s ability to degrade the ergosterol biosynthetic enzymes Erg1 and Erg3.	Ergosterol	110-120	mRNA-binding ubiquitin-specific protease UBP3	Saccharomyces cerevisiae S288C	56-60
33524398-7	2021	Further genetic and biochemical analysis indicated that Ubp3 enhances the proteasome"s ability to degrade the ergosterol biosynthetic enzymes Erg1 and Erg3.	Ergosterol	110-120	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	151-155
33183866-7	2021	Preliminary mechanism study has proved these target compounds can block the biosynthesis of ergosterol by inhibiting the activity of dual targets (SE, CYP51).	Ergosterol	92-102	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	151-156
32985771-0	2021	The ABC transporter Pdr18 is required for yeast thermotolerance due to its role in ergosterol transport and plasma membrane properties.	Ergosterol	83-93	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	20-25
33374996-1	2020	The fungal cytochrome P450 enzyme sterol 14alpha-demethylase (SDM) is a key enzyme in the ergosterol biosynthesis pathway.	Ergosterol	90-100	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	34-60
33396406-2	2020	The ERG3 gene in Candida albicans encodes a sterol C5,6-desaturase, which is essential for ergosterol biosynthesis.	Ergosterol	91-101	potassium voltage-gated channel, subfamily H (eag-related), member 7	Mus musculus	4-8
32791399-2	2020	The squalenee epoxidase (SE) and 14-demethylase (CYP51) are the important rate-limiting enzymes for ergosterol synthesis.	Ergosterol	100-110	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	49-54
32770418-5	2020	Resistance to terbinafine and other allylamines is very rare and usually correlated with point mutations in the squalene epoxidase gene resulting in single amino acid substitutions in the enzyme, which is crucial in the ergosterol synthesis pathway.	Ergosterol	220-230	squalene epoxidase	Homo sapiens	112-130
33255682-2	2020	Two of the six family members-Lam2/Ltc4 (initially Ysp2) and paralog Lam4/Ltc3-localize to ER-plasma membrane (PM) contact sites (CSs) and mediate retrograde ergosterol transport from the PM to the ER.	Ergosterol	158-168	Ysp2p	Saccharomyces cerevisiae S288C	30-34
33255682-2	2020	Two of the six family members-Lam2/Ltc4 (initially Ysp2) and paralog Lam4/Ltc3-localize to ER-plasma membrane (PM) contact sites (CSs) and mediate retrograde ergosterol transport from the PM to the ER.	Ergosterol	158-168	Ysp2p	Saccharomyces cerevisiae S288C	35-39
33255682-2	2020	Two of the six family members-Lam2/Ltc4 (initially Ysp2) and paralog Lam4/Ltc3-localize to ER-plasma membrane (PM) contact sites (CSs) and mediate retrograde ergosterol transport from the PM to the ER.	Ergosterol	158-168	Ysp2p	Saccharomyces cerevisiae S288C	51-55
33255682-2	2020	Two of the six family members-Lam2/Ltc4 (initially Ysp2) and paralog Lam4/Ltc3-localize to ER-plasma membrane (PM) contact sites (CSs) and mediate retrograde ergosterol transport from the PM to the ER.	Ergosterol	158-168	Lam4p	Saccharomyces cerevisiae S288C	69-73
33255682-2	2020	Two of the six family members-Lam2/Ltc4 (initially Ysp2) and paralog Lam4/Ltc3-localize to ER-plasma membrane (PM) contact sites (CSs) and mediate retrograde ergosterol transport from the PM to the ER.	Ergosterol	158-168	Lam4p	Saccharomyces cerevisiae S288C	74-78
33141558-2	2020	We showed recently that the yeast homologue of NPC2 together with its binding partner NCR1 mediates integration of ergosterol, the main sterol in yeast, into the vacuolar membrane.	Ergosterol	115-125	sterol transporter	Saccharomyces cerevisiae S288C	47-51
33141558-2	2020	We showed recently that the yeast homologue of NPC2 together with its binding partner NCR1 mediates integration of ergosterol, the main sterol in yeast, into the vacuolar membrane.	Ergosterol	115-125	sphingolipid transporter	Saccharomyces cerevisiae S288C	86-90
33141558-6	2020	We further identify ergosterol, PC, and PI as endogenous NPC2 ligands.	Ergosterol	20-30	sterol transporter	Saccharomyces cerevisiae S288C	57-61
33141558-7	2020	Using molecular dynamics simulations, we show that NPC2"s binding pocket can adapt to the ligand shape and closes around bound ergosterol.	Ergosterol	127-137	sterol transporter	Saccharomyces cerevisiae S288C	51-55
32857223-3	2020	Estimates based on ergosterol may, however, be distorted by exposure to demethylase inhibiting (DMI) fungicides, interfering with sterol synthesis.	Ergosterol	19-29	methyl-CpG binding domain protein 2	Homo sapiens	72-83
33081232-1	2020	Recently, mutations in the 3-hydroxy-3-methylglutaryl-coenzyme-A-reductase-encoding gene (hmg1), a gene involved in ergosterol production, were associated with triazole-resistance in Aspergillus fumigatus.	Ergosterol	116-126	high mobility group box 1 pseudogene 5	Homo sapiens	90-94
32868373-11	2020	Erg25 is a methyl oxidase that converts dimethylzymosterol to zymosterol, a precursor of the plasma membrane sterol, ergosterol.	Ergosterol	117-127	methylsterol monooxygenase	Saccharomyces cerevisiae S288C	0-5
32605038-6	2020	The mRNA expression levels of 5alpha-reductase type 2 and AR were higher in the carcinogenesis group than in the control group but were significantly decreased by ergosterol administration.	Ergosterol	163-173	androgen receptor	Rattus norvegicus	58-60
32566991-6	2020	This study shows that the overexpression of SUT2 promoted the expression of AOX1 and increases ergosterol content in cells.	Ergosterol	95-105	Sut2p	Saccharomyces cerevisiae S288C	44-48
32446112-12	2020	In mice, ERG treatment greatly decreased fasting blood glucose levels, inflammatory cytokine levels, and renal injury, while it enhanced the insulin level.	Ergosterol	9-12	insulin	Homo sapiens	141-148
32930220-7	2020	The calibration curve of ergosterol showed good linearity (R = 0.9999) within the test range (4.21-25.27 mug mL-1).	Ergosterol	25-35	L1 cell adhesion molecule	Mus musculus	109-113
32612142-4	2020	Furthermore, screening of suppressor mutations that confer low pH resistance to sur1  csh1  cells revealed that a change in ergosterol homeostasis at plasma membranes can rescue the hypersensitivity, suggesting the functional relationship between complex sphingolipids and ergosterol under low pH conditions.	Ergosterol	124-134	mannosylinositol phosphorylceramide synthase catalytic subunit SUR1	Saccharomyces cerevisiae S288C	80-84
32612142-4	2020	Furthermore, screening of suppressor mutations that confer low pH resistance to sur1  csh1  cells revealed that a change in ergosterol homeostasis at plasma membranes can rescue the hypersensitivity, suggesting the functional relationship between complex sphingolipids and ergosterol under low pH conditions.	Ergosterol	124-134	mannosylinositol phosphorylceramide synthase catalytic subunit CSH1	Saccharomyces cerevisiae S288C	86-90
32612142-4	2020	Furthermore, screening of suppressor mutations that confer low pH resistance to sur1  csh1  cells revealed that a change in ergosterol homeostasis at plasma membranes can rescue the hypersensitivity, suggesting the functional relationship between complex sphingolipids and ergosterol under low pH conditions.	Ergosterol	273-283	mannosylinositol phosphorylceramide synthase catalytic subunit CSH1	Saccharomyces cerevisiae S288C	86-90
32541034-4	2020	We report here the discovery of ergosteryl-3beta-O-l-aspartate (Erg-Asp), a conjugated sterol that is produced by the tRNA-dependent addition of aspartate to the 3beta-OH group of ergosterol, the major sterol found in fungal membranes.	Ergosterol	180-190	ETS transcription factor ERG	Homo sapiens	64-67
32441029-3	2020	CYP11A1 similarly initiates the metabolism of lumisterol (L3) through sequential hydroxylation of the side chain to produce 20(OH)L3, 22(OH)L3, 20,22(OH)2L3 and 24(OH)L3.	Ergosterol	46-56	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	0-7
32220664-2	2020	Ergosterol is an important structural component of the fungal cell membrane, its synthetases (squalene epoxidase (SE) and 14alpha-demethylase (CYP51)) are considered as the key points to block the ergosterol synthesis.	Ergosterol	0-10	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	143-148
32220664-2	2020	Ergosterol is an important structural component of the fungal cell membrane, its synthetases (squalene epoxidase (SE) and 14alpha-demethylase (CYP51)) are considered as the key points to block the ergosterol synthesis.	Ergosterol	197-207	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	143-148
32413406-6	2020	We find that phosphatidylserine and ergosterol are essential for Lyp1 function, and the transport activity displays a sigmoidal relationship with the concentration of these lipids.	Ergosterol	36-46	lysine permease	Saccharomyces cerevisiae S288C	65-69
32612595-0	2020	Phenotypic Analysis of Mutants of Ergosterol Biosynthesis Genes (ERG3 and ERG4) in the Red Yeast Xanthophyllomyces dendrorhous.	Ergosterol	34-44	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	65-69
32612595-0	2020	Phenotypic Analysis of Mutants of Ergosterol Biosynthesis Genes (ERG3 and ERG4) in the Red Yeast Xanthophyllomyces dendrorhous.	Ergosterol	34-44	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	74-78
32612595-3	2020	The interruption of the CYP61 gene, which is involved in the synthesis of ergosterol (mutant CBS.cyp61 -), resulted in a phenotype that overproduces carotenoids due to the activation of the SREBP pathway.	Ergosterol	74-84	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	24-29
32612595-3	2020	The interruption of the CYP61 gene, which is involved in the synthesis of ergosterol (mutant CBS.cyp61 -), resulted in a phenotype that overproduces carotenoids due to the activation of the SREBP pathway.	Ergosterol	74-84	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	97-102
32612595-4	2020	In this work, we constructed other mutants of ergosterol biosynthesis in this yeast to evaluate whether they have the same phenotype as mutant CBS.cyp61 -.	Ergosterol	46-56	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	147-152
32077151-0	2020	The COP9 signalosome mediates the Spt23 regulated fatty acid desaturation and ergosterol biosynthesis.	Ergosterol	78-88	Spt23p	Saccharomyces cerevisiae S288C	34-39
31646753-3	2020	Fruit-specific overexpression of LYCOPENE beta-CYCLASE (LCYb) resulted in increased beta-carotene (provitamin A) content.	Ergosterol	99-111	lycopene beta cyclase, chloroplastic	Solanum lycopersicum	33-54
31954176-4	2020	Here we show that a novel target of rapamycin (TOR)-interacting transcriptional activator Vhr2 is required for full expression of some ERG genes for ergosterol biogenesis and for proper sorting of the tryptophan permease Tat2 in budding yeast.	Ergosterol	149-159	Vhr2p	Saccharomyces cerevisiae S288C	90-94
32077151-7	2020	Spt23 is a novel activator of lipid desaturation and ergosterol biosynthesis.	Ergosterol	53-63	Spt23p	Saccharomyces cerevisiae S288C	0-5
31504756-3	2020	The data revealed mutations of the ergosterol biosynthetic pathway-related genes in the T. asahii genome of the fluconazole-resistant strain, that is, there were 36 novel mutations of the ERG11 gene, three point mutations (V458L, D457V, and D334S) in the ERG3, and a missense mutation (E349D) in ERG5 in the fluconazole-resistant strain of the T. asahii genome.	Ergosterol	35-45	ETS transcription factor ERG	Homo sapiens	255-259
31062656-2	2020	The target of triazoles is the product of the ERG11 gene, the cytochrome P450 sterol 14alpha-demethylase (CYP51), which is part of the ergosterol biosynthetic pathway.	Ergosterol	135-145	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	62-104
31062656-2	2020	The target of triazoles is the product of the ERG11 gene, the cytochrome P450 sterol 14alpha-demethylase (CYP51), which is part of the ergosterol biosynthetic pathway.	Ergosterol	135-145	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	106-111
32005728-2	2020	In yeast, the enzyme acetyl-CoA acetyltransferase (ERG10) catalyzes the Claisen condensation of two acetyl-CoA molecules to acetoacetyl-CoA in the ergosterol biosynthesis pathway and is reported critical for cell viability.	Ergosterol	147-157	acetyl-CoA C-acetyltransferase	Saccharomyces cerevisiae S288C	51-56
32146854-3	2021	This differential effect suggests that the effect of ergosterol might be related to its ability to act as an Androgen Receptor ligand.	Ergosterol	53-63	androgen receptor	Homo sapiens	109-126
32146854-4	2021	In silico Molecular Dynamics simulations were performed to analyze the interaction mechanism between androgen receptor and ergosterol, in comparison with natural ligands, 5alpha-dihydrotestosterone and testosterone.	Ergosterol	123-133	androgen receptor	Homo sapiens	101-118
32146854-5	2021	Our model suggests that the binding of androgen receptor with ergosterol is thermodinamically feasible, which is concordant with our experimental results.	Ergosterol	62-72	androgen receptor	Homo sapiens	39-56
32564734-10	2020	We have found that the deletion of ergosterol biosynthesis genes ERG2 and ERG6 reduces the effect of LAM2 deletion.	Ergosterol	35-45	C-8 sterol isomerase ERG2	Saccharomyces cerevisiae S288C	65-69
32564734-10	2020	We have found that the deletion of ergosterol biosynthesis genes ERG2 and ERG6 reduces the effect of LAM2 deletion.	Ergosterol	35-45	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	74-78
32564734-10	2020	We have found that the deletion of ergosterol biosynthesis genes ERG2 and ERG6 reduces the effect of LAM2 deletion.	Ergosterol	35-45	Ysp2p	Saccharomyces cerevisiae S288C	101-105
32564734-11	2020	Deletion of LAM2 in the Deltaerg4 strain lacking the gene of the last step of ergosterol biosynthesis, significantly increased the proportion of dead cells and decreased the growth rate of the yeast suspension culture even in the absence of the pheromone.	Ergosterol	78-88	Ysp2p	Saccharomyces cerevisiae S288C	12-16
32564734-12	2020	We suggest that the absence of the effect of LAM2 deletion in the Deltaerg6 and Deltaerg2 strains indicates the inability of Lam2p to transport some ergosterol biosynthesis intermediates, such as lanosterol.	Ergosterol	149-159	Ysp2p	Saccharomyces cerevisiae S288C	125-130
31932990-3	2020	We aim to prepare ergosterol-loaded nanostructured lipid carriers (ERG-NLCs) to enhance the solubility and oral bioavailability of ergosterol.	Ergosterol	18-28	ETS transcription factor ERG	Homo sapiens	67-70
31874368-6	2020	However, treatment of RAW264.7 cells and SD rats with ergosterol inhibited CSE-induced inflammatory by decreasing ROS, IL-6 and TNF-alpha, and increasing IL-10 and TGF-beta, shuffling the dynamic polarization of macrophages from M1 to M2 both in vitro and in vivo.	Ergosterol	54-64	interleukin 6	Rattus norvegicus	119-123
31874368-6	2020	However, treatment of RAW264.7 cells and SD rats with ergosterol inhibited CSE-induced inflammatory by decreasing ROS, IL-6 and TNF-alpha, and increasing IL-10 and TGF-beta, shuffling the dynamic polarization of macrophages from M1 to M2 both in vitro and in vivo.	Ergosterol	54-64	tumor necrosis factor	Rattus norvegicus	128-137
31874368-6	2020	However, treatment of RAW264.7 cells and SD rats with ergosterol inhibited CSE-induced inflammatory by decreasing ROS, IL-6 and TNF-alpha, and increasing IL-10 and TGF-beta, shuffling the dynamic polarization of macrophages from M1 to M2 both in vitro and in vivo.	Ergosterol	54-64	interleukin 10	Rattus norvegicus	154-159
31874368-6	2020	However, treatment of RAW264.7 cells and SD rats with ergosterol inhibited CSE-induced inflammatory by decreasing ROS, IL-6 and TNF-alpha, and increasing IL-10 and TGF-beta, shuffling the dynamic polarization of macrophages from M1 to M2 both in vitro and in vivo.	Ergosterol	54-64	transforming growth factor alpha	Rattus norvegicus	164-172
31874368-7	2020	Ergosterol also decreased the expression of M1 marker CD40, while increased that of M2 marker CD163.	Ergosterol	0-10	CD163 molecule	Rattus norvegicus	94-99
31874368-8	2020	Moreover, ergosterol improved the lung characters in rats by decreasing MMP-9.	Ergosterol	10-20	matrix metallopeptidase 9	Rattus norvegicus	72-77
31874368-9	2020	Furthermore, ergosterol elevated HDAC3 activation and suppressed P300/CBP and PCAF activation as well as acetyl NF-kappaB/p65 and IKKbeta, demonstrating that HDAC3 deacetylation was involved in the effect of ergosterol on macrophage polarization.	Ergosterol	13-23	histone deacetylase 3	Rattus norvegicus	33-38
31874368-9	2020	Furthermore, ergosterol elevated HDAC3 activation and suppressed P300/CBP and PCAF activation as well as acetyl NF-kappaB/p65 and IKKbeta, demonstrating that HDAC3 deacetylation was involved in the effect of ergosterol on macrophage polarization.	Ergosterol	13-23	CREB binding protein	Rattus norvegicus	65-73
31874368-9	2020	Furthermore, ergosterol elevated HDAC3 activation and suppressed P300/CBP and PCAF activation as well as acetyl NF-kappaB/p65 and IKKbeta, demonstrating that HDAC3 deacetylation was involved in the effect of ergosterol on macrophage polarization.	Ergosterol	13-23	lysine acetyltransferase 2B	Rattus norvegicus	78-82
31874368-9	2020	Furthermore, ergosterol elevated HDAC3 activation and suppressed P300/CBP and PCAF activation as well as acetyl NF-kappaB/p65 and IKKbeta, demonstrating that HDAC3 deacetylation was involved in the effect of ergosterol on macrophage polarization.	Ergosterol	13-23	synaptotagmin 1	Rattus norvegicus	122-125
31874368-9	2020	Furthermore, ergosterol elevated HDAC3 activation and suppressed P300/CBP and PCAF activation as well as acetyl NF-kappaB/p65 and IKKbeta, demonstrating that HDAC3 deacetylation was involved in the effect of ergosterol on macrophage polarization.	Ergosterol	13-23	component of inhibitor of nuclear factor kappa B kinase complex	Rattus norvegicus	130-137
31874368-9	2020	Furthermore, ergosterol elevated HDAC3 activation and suppressed P300/CBP and PCAF activation as well as acetyl NF-kappaB/p65 and IKKbeta, demonstrating that HDAC3 deacetylation was involved in the effect of ergosterol on macrophage polarization.	Ergosterol	13-23	histone deacetylase 3	Rattus norvegicus	158-163
31874368-9	2020	Furthermore, ergosterol elevated HDAC3 activation and suppressed P300/CBP and PCAF activation as well as acetyl NF-kappaB/p65 and IKKbeta, demonstrating that HDAC3 deacetylation was involved in the effect of ergosterol on macrophage polarization.	Ergosterol	208-218	histone deacetylase 3	Rattus norvegicus	158-163
31806730-6	2020	We assessed STP1 function in Deltastp1 strains derived from the wild type and a mutant of ergosterol biosynthesis that overproduces carotenoids and sterols.	Ergosterol	90-100	Stp1p	Saccharomyces cerevisiae S288C	12-16
31734363-3	2020	Anti-candida activity of Mo-CBP2 decreased in the presence of ergosterol, which was not observed with antioxidant agents.	Ergosterol	62-72	serpin family H member 1	Homo sapiens	28-32
31932990-3	2020	We aim to prepare ergosterol-loaded nanostructured lipid carriers (ERG-NLCs) to enhance the solubility and oral bioavailability of ergosterol.	Ergosterol	131-141	ETS transcription factor ERG	Homo sapiens	67-70
31932990-7	2020	In pharmacokinetic study, Cmax and AUC0-  of ergosterol in ERG-NLCs were obviously enhanced, and the relative oral bioavailability of ERG-NLCs was 277.56% higher than that of raw ergosterol.	Ergosterol	45-55	ETS transcription factor ERG	Homo sapiens	59-62
31932990-7	2020	In pharmacokinetic study, Cmax and AUC0-  of ergosterol in ERG-NLCs were obviously enhanced, and the relative oral bioavailability of ERG-NLCs was 277.56% higher than that of raw ergosterol.	Ergosterol	45-55	ETS transcription factor ERG	Homo sapiens	134-137
31932990-8	2020	Moreover, the in vitro pharmacodynamic study indicated that ERG-NLCs inhibited high-glucose-stimulated mesangial cells over proliferation and ECM accumulation more effectively compared to raw ergosterol.	Ergosterol	192-202	ETS transcription factor ERG	Homo sapiens	60-63
31932990-9	2020	In conclusion, the validated ERG-NLCs showed that NLCs mediated delivery could be used as potential vehicle to enhance solubility, oral bioavailability and therapeutic efficacy of ergosterol.	Ergosterol	180-190	ETS transcription factor ERG	Homo sapiens	29-32
31606910-4	2020	In addition, another key enzyme in sterol biosynthesis, squalene epoxidase (ERG1) was inhibited by an experimentally-defined amount of the inhibitor terbinafine in order to reduce flux of squalene towards ergosterol biosynthesis while retaining sufficient activity to maintain cell viability and growth.	Ergosterol	205-215	squalene monooxygenase	Saccharomyces cerevisiae S288C	76-80
31813476-5	2020	This model suggests that Sch A occupies the same binding pocket in Osh2 which is occupied by its natural substrate, ergosterol.	Ergosterol	116-126	oxysterol-binding protein related protein OSH2	Saccharomyces cerevisiae S288C	67-71
31805905-11	2019	Four major compounds isolated from APH fraction were identified to be two triacylglycerols, linoleic acid and ergosterol.	Ergosterol	110-120	acylaminoacyl-peptide hydrolase	Homo sapiens	35-38
31610510-2	2019	They typically work by inhibiting cytochrome P450 enzymes, primarily CYP51 of the ergosterol biosynthesis pathway, thus damaging the fungal cell membrane.	Ergosterol	82-92	cytochrome P450, family 51	Rattus norvegicus	69-74
31455610-5	2019	However, a Bfr1 RNA-binding mutant is impaired in binding to ERG4 mRNA, which encodes an enzyme required for the final step of ergosterol biosynthesis.	Ergosterol	127-137	Bfr1p	Saccharomyces cerevisiae S288C	11-15
31455610-5	2019	However, a Bfr1 RNA-binding mutant is impaired in binding to ERG4 mRNA, which encodes an enzyme required for the final step of ergosterol biosynthesis.	Ergosterol	127-137	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	61-65
31412941-4	2019	Import of ergosterol in yeast can take place via the ABC transporters Aus1/Pdr11 under anaerobic growth conditions, eventually followed by rapid non-vesicular sterol transport to the endoplasmic reticulum (ER).	Ergosterol	10-20	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	70-74
31409644-0	2019	The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors.	Ergosterol	103-113	pantothenate kinase	Saccharomyces cerevisiae S288C	10-29
31409644-0	2019	The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors.	Ergosterol	103-113	pantothenate kinase	Saccharomyces cerevisiae S288C	30-34
31398949-5	2019	Families CYP51 and CYP61 (represented by the ergosterol biosynthetic genes ERG11 and ERG5, respectively) were essentially ubiquitous among the budding yeasts while families CYP52 (alkane/fatty acid hydroxylases), CYP56 (N-formyl-l-tyrosine oxidase) displayed several instances of gene loss at the genus or family level.	Ergosterol	45-55	sterol 14-demethylase	Saccharomyces cerevisiae S288C	9-14
31398949-5	2019	Families CYP51 and CYP61 (represented by the ergosterol biosynthetic genes ERG11 and ERG5, respectively) were essentially ubiquitous among the budding yeasts while families CYP52 (alkane/fatty acid hydroxylases), CYP56 (N-formyl-l-tyrosine oxidase) displayed several instances of gene loss at the genus or family level.	Ergosterol	45-55	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	19-24
31398949-5	2019	Families CYP51 and CYP61 (represented by the ergosterol biosynthetic genes ERG11 and ERG5, respectively) were essentially ubiquitous among the budding yeasts while families CYP52 (alkane/fatty acid hydroxylases), CYP56 (N-formyl-l-tyrosine oxidase) displayed several instances of gene loss at the genus or family level.	Ergosterol	45-55	sterol 14-demethylase	Saccharomyces cerevisiae S288C	75-80
31412941-4	2019	Import of ergosterol in yeast can take place via the ABC transporters Aus1/Pdr11 under anaerobic growth conditions, eventually followed by rapid non-vesicular sterol transport to the endoplasmic reticulum (ER).	Ergosterol	10-20	ATP-binding cassette multidrug transporter PDR11	Saccharomyces cerevisiae S288C	75-80
31270147-6	2019	Treatment of 16HBE cells and Balb/c mice with ergosterol inhibited CSE-induced inflammatory and oxidative stress and apoptosis by inhibiting the activation of NF-kappaB/p65.	Ergosterol	46-56	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	159-168
31270147-6	2019	Treatment of 16HBE cells and Balb/c mice with ergosterol inhibited CSE-induced inflammatory and oxidative stress and apoptosis by inhibiting the activation of NF-kappaB/p65.	Ergosterol	46-56	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	169-172
31270147-4	2019	The objective of this work was to investigate the effects of ergosterol on anti-inflammatory and antioxidative stress as well as anti-apoptosis in a cigarette smoke extract (CSE)-induced COPD model both in vitro and in vivo Our results demonstrate that CSE induced inflammatory and oxidative stress and apoptosis with the involvement of the Bcl-2 family proteins via the nuclear factor kappa B (NF-kappaB)/p65 pathway in both 16HBE cells and Balb/c mice.	Ergosterol	61-71	nuclear factor kappa B subunit 1	Homo sapiens	371-393
31270147-4	2019	The objective of this work was to investigate the effects of ergosterol on anti-inflammatory and antioxidative stress as well as anti-apoptosis in a cigarette smoke extract (CSE)-induced COPD model both in vitro and in vivo Our results demonstrate that CSE induced inflammatory and oxidative stress and apoptosis with the involvement of the Bcl-2 family proteins via the nuclear factor kappa B (NF-kappaB)/p65 pathway in both 16HBE cells and Balb/c mice.	Ergosterol	61-71	nuclear factor kappa B subunit 1	Homo sapiens	395-404
31270147-4	2019	The objective of this work was to investigate the effects of ergosterol on anti-inflammatory and antioxidative stress as well as anti-apoptosis in a cigarette smoke extract (CSE)-induced COPD model both in vitro and in vivo Our results demonstrate that CSE induced inflammatory and oxidative stress and apoptosis with the involvement of the Bcl-2 family proteins via the nuclear factor kappa B (NF-kappaB)/p65 pathway in both 16HBE cells and Balb/c mice.	Ergosterol	61-71	RELA proto-oncogene, NF-kB subunit	Homo sapiens	406-409
31270147-7	2019	Ergosterol suppressed apoptosis by inhibiting the expression of the apoptosis-related proteins both in vitro and in vivo Moreover, the usage of QNZ (an inhibitor of NF-kappaB) also partly demonstrated that NF-kappaB/p65 pathway was involved in the ergosterol protective progress.	Ergosterol	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	165-174
31270147-7	2019	Ergosterol suppressed apoptosis by inhibiting the expression of the apoptosis-related proteins both in vitro and in vivo Moreover, the usage of QNZ (an inhibitor of NF-kappaB) also partly demonstrated that NF-kappaB/p65 pathway was involved in the ergosterol protective progress.	Ergosterol	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	206-215
31270147-7	2019	Ergosterol suppressed apoptosis by inhibiting the expression of the apoptosis-related proteins both in vitro and in vivo Moreover, the usage of QNZ (an inhibitor of NF-kappaB) also partly demonstrated that NF-kappaB/p65 pathway was involved in the ergosterol protective progress.	Ergosterol	0-10	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	216-219
31270147-7	2019	Ergosterol suppressed apoptosis by inhibiting the expression of the apoptosis-related proteins both in vitro and in vivo Moreover, the usage of QNZ (an inhibitor of NF-kappaB) also partly demonstrated that NF-kappaB/p65 pathway was involved in the ergosterol protective progress.	Ergosterol	248-258	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	165-174
31270147-7	2019	Ergosterol suppressed apoptosis by inhibiting the expression of the apoptosis-related proteins both in vitro and in vivo Moreover, the usage of QNZ (an inhibitor of NF-kappaB) also partly demonstrated that NF-kappaB/p65 pathway was involved in the ergosterol protective progress.	Ergosterol	248-258	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	206-215
31270147-8	2019	These results show that ergosterol suppressed COPD inflammatory and oxidative stress and apoptosis through the NF-kappaB/p65 pathway, suggesting that ergosterol may be partially responsible for the therapeutic effects of cultured C. sinensis on COPD patients.	Ergosterol	24-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	111-120
31270147-8	2019	These results show that ergosterol suppressed COPD inflammatory and oxidative stress and apoptosis through the NF-kappaB/p65 pathway, suggesting that ergosterol may be partially responsible for the therapeutic effects of cultured C. sinensis on COPD patients.	Ergosterol	24-34	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	121-124
31270147-8	2019	These results show that ergosterol suppressed COPD inflammatory and oxidative stress and apoptosis through the NF-kappaB/p65 pathway, suggesting that ergosterol may be partially responsible for the therapeutic effects of cultured C. sinensis on COPD patients.	Ergosterol	150-160	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	111-120
30039474-5	2019	In addition, squalene yield in ergosterol mutant strains has been analyzed and was found to be 1.8-fold and 3.4-fold higher in ERG6 and ERG11 deletion strains, respectively, than in BY4742.	Ergosterol	31-41	sterol 14-demethylase	Saccharomyces cerevisiae S288C	136-141
31186322-0	2019	Evidence that Ergosterol Biosynthesis Modulates Activity of the Pdr1 Transcription Factor in Candida glabrata.	Ergosterol	14-24	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	64-68
31186322-7	2019	Here we test the idea that reduction of ergosterol biosynthesis (as occurs in the presence of azole drugs) might trigger activation of Pdr1 function.	Ergosterol	40-50	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	135-139
31186322-8	2019	Using two different means of genetically inhibiting ergosterol biosynthesis, we demonstrated that Pdr1 activity and target gene expression are elevated in the absence of azole drug.	Ergosterol	52-62	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	98-102
31186322-9	2019	Blocks at different points in the ergosterol pathway lead to Pdr1 activation as well as to induction of other genes in this pathway.	Ergosterol	34-44	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	61-65
31186322-10	2019	Delivery of the signal from the ergosterol pathway to Pdr1 involves the transcription factor Upc2A, an ERG gene regulator.	Ergosterol	32-42	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	54-58
31186322-12	2019	Our studies argue for a physiological link between ergosterol biosynthesis and Pdr1-dependent gene regulation that is not restricted to efflux of azole drugs.IMPORTANCE A likely contributor to the increased incidence of non-albicans candidemias involving Candida glabrata is the ease with which this yeast acquires azole resistance, in large part due to induction of the ATP-binding cassette transporter-encoding gene CDR1 Azole drugs lead to induction of Pdr1 transactivation, with a central model being that this factor binds these drugs directly.	Ergosterol	51-61	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	79-83
31186322-12	2019	Our studies argue for a physiological link between ergosterol biosynthesis and Pdr1-dependent gene regulation that is not restricted to efflux of azole drugs.IMPORTANCE A likely contributor to the increased incidence of non-albicans candidemias involving Candida glabrata is the ease with which this yeast acquires azole resistance, in large part due to induction of the ATP-binding cassette transporter-encoding gene CDR1 Azole drugs lead to induction of Pdr1 transactivation, with a central model being that this factor binds these drugs directly.	Ergosterol	51-61	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	456-460
31186322-15	2019	We interpret these data as support for the view that Pdr1 function is responsive to ergosterol biosynthesis and suggest that this connection reveals the normal physiological circuitry in which Pdr1 participates.	Ergosterol	84-94	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	53-57
31186322-15	2019	We interpret these data as support for the view that Pdr1 function is responsive to ergosterol biosynthesis and suggest that this connection reveals the normal physiological circuitry in which Pdr1 participates.	Ergosterol	84-94	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	193-197
31039479-0	2019	Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms.	Ergosterol	58-68	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
31039479-0	2019	Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms.	Ergosterol	58-68	tumor protein p53	Homo sapiens	150-153
30039474-5	2019	In addition, squalene yield in ergosterol mutant strains has been analyzed and was found to be 1.8-fold and 3.4-fold higher in ERG6 and ERG11 deletion strains, respectively, than in BY4742.	Ergosterol	31-41	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	127-131
31200551-2	2019	The azole drug fluconazole, used in the treatment of diseases caused by some species of Tremellomycetes, inhibits cytochrome P450 monooxygenase CYP51, an enzyme that converts lanosterol into an essential component of the fungal cell membrane ergosterol.	Ergosterol	242-252	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	144-149
30785834-5	2019	Deletion of SPF1 resulted in increased sensitivity to inhibitors of sterol production, a marked change in the ergosterol/lanosterol ratio, accumulation of sterols in the plasma membrane, and cytosolic accumulation of lipid bodies.	Ergosterol	110-120	ion-transporting P-type ATPase SPF1	Saccharomyces cerevisiae S288C	12-16
30639288-0	2019	Psd2 pea defensin shows a preference for mimetic membrane rafts enriched with glucosylceramide and ergosterol.	Ergosterol	99-109	pleckstrin and Sec7 domain containing 2	Homo sapiens	0-4
30639288-3	2019	Protein-lipid overlay assays indicated that Psd2 recognizes Fusarium solani glucosylceramide (GlcCerF.solani) and ergosterol (Erg) in addition to phosphatidylcholine (POPC) and some phosphatidylinositol species, such as PtdIns (3)P, (5)P and (3,5)P2, suggesting that these lipids may play important roles as Psd2 targets.	Ergosterol	114-124	pleckstrin and Sec7 domain containing 2	Homo sapiens	44-48
30639288-3	2019	Protein-lipid overlay assays indicated that Psd2 recognizes Fusarium solani glucosylceramide (GlcCerF.solani) and ergosterol (Erg) in addition to phosphatidylcholine (POPC) and some phosphatidylinositol species, such as PtdIns (3)P, (5)P and (3,5)P2, suggesting that these lipids may play important roles as Psd2 targets.	Ergosterol	126-129	pleckstrin and Sec7 domain containing 2	Homo sapiens	44-48
30777305-6	2019	Thus, sterols such as cholesterol in higher eukaryotes or ergosterol in fungi may regulate the VDAC oligomeric state and may provide a potential target for the modulation of apoptotic signaling by effecting VDAC-VDAC and VDAC-hexokinase interactions.	Ergosterol	58-68	hexokinase 1	Homo sapiens	226-236
30462528-0	2019	Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane fusion in Saccharomyces cerevisiae.	Ergosterol	0-10	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	26-31
30553056-5	2019	The loss of mitochondrial DNA in the  erg27 strain is fully suppressed by exogenous addition of ergosterol.	Ergosterol	96-106	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	38-43
30462528-2	2019	Although ergosterol, the major sterol in yeast, is essential for fusion of Sey1p (yeast atlastin)-containing liposomes with an ER-mimicking lipid composition, fusion of phosphatidylcholine/phosphatidylserine liposomes does not require sterols.	Ergosterol	9-19	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	75-80
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	69-79	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	0-5
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	69-79	sterol 14-demethylase	Saccharomyces cerevisiae S288C	33-39
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	69-79	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	44-49
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	69-79	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	110-115
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	69-79	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	110-115
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	125-135	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	0-5
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	125-135	sterol 14-demethylase	Saccharomyces cerevisiae S288C	33-39
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	125-135	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	44-49
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	125-135	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	110-115
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	125-135	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	110-115
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	125-135	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	0-5
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	125-135	sterol 14-demethylase	Saccharomyces cerevisiae S288C	33-39
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	125-135	delta(24(24(1)))-sterol reductase	Saccharomyces cerevisiae S288C	44-49
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	125-135	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	110-115
30462528-7	2019	Sey1p physically interacted with Erg11p and Erg4p, which function in ergosterol biosynthesis, suggesting that Sey1p recruits ergosterol-synthesizing enzymes to fusion sites and thereby enriches ergosterol, which, in turn, may recruit more Sey1p.	Ergosterol	125-135	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	110-115
30462528-9	2019	Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane fusion in Saccharomyces cerevisiae.	Ergosterol	0-10	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	26-31
30823598-0	2019	Ergosterol Ameliorates Diabetic Nephropathy by Attenuating Mesangial Cell Proliferation and Extracellular Matrix Deposition via the TGF-beta1/Smad2 Signaling Pathway.	Ergosterol	0-10	transforming growth factor, beta 1	Mus musculus	132-141
30823598-0	2019	Ergosterol Ameliorates Diabetic Nephropathy by Attenuating Mesangial Cell Proliferation and Extracellular Matrix Deposition via the TGF-beta1/Smad2 Signaling Pathway.	Ergosterol	0-10	SMAD family member 2	Mus musculus	142-147
30823598-6	2019	In vitro, ergosterol suppressed proliferation, reduced the levels of ECM proteins, and increased the expression of matrix metalloproteinase-2 and -9 in high glucose-induced mesangial cells; Furthermore, ergosterol markedly improved transforming growth factor-beta1 (TGF-beta1) expression, enhanced phosphorylation levels of drosophila mothers against decapentaplegic 2 (Smad2), and regulated the downstream factors in vivo and in vitro.	Ergosterol	10-20	Matrix metalloproteinase 2	Drosophila melanogaster	115-148
30823598-6	2019	In vitro, ergosterol suppressed proliferation, reduced the levels of ECM proteins, and increased the expression of matrix metalloproteinase-2 and -9 in high glucose-induced mesangial cells; Furthermore, ergosterol markedly improved transforming growth factor-beta1 (TGF-beta1) expression, enhanced phosphorylation levels of drosophila mothers against decapentaplegic 2 (Smad2), and regulated the downstream factors in vivo and in vitro.	Ergosterol	10-20	transforming growth factor, beta 1	Mus musculus	266-275
30823598-6	2019	In vitro, ergosterol suppressed proliferation, reduced the levels of ECM proteins, and increased the expression of matrix metalloproteinase-2 and -9 in high glucose-induced mesangial cells; Furthermore, ergosterol markedly improved transforming growth factor-beta1 (TGF-beta1) expression, enhanced phosphorylation levels of drosophila mothers against decapentaplegic 2 (Smad2), and regulated the downstream factors in vivo and in vitro.	Ergosterol	10-20	Smad on X	Drosophila melanogaster	370-375
30823598-7	2019	(4) Conclusions: Ergosterol alleviated mesangial cell proliferation and the subsequent ECM deposition by regulating the TGF-beta1/Smad2 signaling pathway.	Ergosterol	17-27	transforming growth factor, beta 1	Mus musculus	120-129
30823598-7	2019	(4) Conclusions: Ergosterol alleviated mesangial cell proliferation and the subsequent ECM deposition by regulating the TGF-beta1/Smad2 signaling pathway.	Ergosterol	17-27	Smad on X	Drosophila melanogaster	130-135
30696744-7	2019	We found that Hsp90 is essential for growth in C. auris and that it enables tolerance of clinical isolates with respect to the azoles, which inhibit biosynthesis of the membrane sterol ergosterol.	Ergosterol	185-195	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	14-19
30696744-15	2019	We showed that Hsp90 is essential for growth in C. auris and is important for tolerance of the clinically important azole antifungals, which block ergosterol biosynthesis.	Ergosterol	147-157	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	15-20
30745018-1	2019	BACKGROUND: The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgr) catalyzes the synthesis of mevalonate, a key compound for the synthesis of cholesterol in humans and ergosterol in fungi.	Ergosterol	179-189	high mobility group AT-hook 1	Homo sapiens	72-76
30098030-0	2018	Overexpression of Ecm22 improves ergosterol biosynthesis in Saccharomyces cerevisiae.	Ergosterol	33-43	Ecm22p	Saccharomyces cerevisiae S288C	18-23
30443546-11	2018	Furthermore, we showed that the concurrent dynamic control of ERG20 and ERG9 expression, using ergosterol and carbon source regulation mechanisms, could substantially improve diterpene titer.	Ergosterol	95-105	bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase	Saccharomyces cerevisiae S288C	62-67
30443546-11	2018	Furthermore, we showed that the concurrent dynamic control of ERG20 and ERG9 expression, using ergosterol and carbon source regulation mechanisms, could substantially improve diterpene titer.	Ergosterol	95-105	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	72-76
30524481-4	2018	The action mechanism of main antifungal compound was investigated by molecular docking using the enzyme sterol 14-alpha demethylase, CYP51, required for ergosterol biosynthesis.	Ergosterol	153-163	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	104-131
30524481-4	2018	The action mechanism of main antifungal compound was investigated by molecular docking using the enzyme sterol 14-alpha demethylase, CYP51, required for ergosterol biosynthesis.	Ergosterol	153-163	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	133-138
30098030-2	2018	To clarify the influence of transcriptional regulation on the ergosterol content, transcription factor Ecm22 was overexpressed in S. cerevisiae.	Ergosterol	62-72	Ecm22p	Saccharomyces cerevisiae S288C	103-108
30098030-6	2018	Among truncated ECM22 fragments, only the 1440-bp DNA fragment exerted almost the same impact on ergosterol content as that of the full-length gene.	Ergosterol	97-107	Ecm22p	Saccharomyces cerevisiae S288C	16-21
30450126-9	2018	Interestingly, the accumulation of ergosterol was found to be a protective mechanism of yeast exposed to organic acids, and the ERG1 gene in ergosterol biosynthesis played a key in ergosterol-mediated acid tolerance, as perturbing the expression of this gene caused rapid loss of viability.	Ergosterol	35-45	squalene monooxygenase	Saccharomyces cerevisiae S288C	128-132
30450126-9	2018	Interestingly, the accumulation of ergosterol was found to be a protective mechanism of yeast exposed to organic acids, and the ERG1 gene in ergosterol biosynthesis played a key in ergosterol-mediated acid tolerance, as perturbing the expression of this gene caused rapid loss of viability.	Ergosterol	141-151	squalene monooxygenase	Saccharomyces cerevisiae S288C	128-132
30450126-9	2018	Interestingly, the accumulation of ergosterol was found to be a protective mechanism of yeast exposed to organic acids, and the ERG1 gene in ergosterol biosynthesis played a key in ergosterol-mediated acid tolerance, as perturbing the expression of this gene caused rapid loss of viability.	Ergosterol	141-151	squalene monooxygenase	Saccharomyces cerevisiae S288C	128-132
30126959-6	2018	Overexpression of LDM or Ncp1 modified the ergosterol content of yeast and affected growth inhibition by the polyene antibiotic amphotericin B.	Ergosterol	43-53	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	18-21
30126959-6	2018	Overexpression of LDM or Ncp1 modified the ergosterol content of yeast and affected growth inhibition by the polyene antibiotic amphotericin B.	Ergosterol	43-53	NADPH--hemoprotein reductase	Saccharomyces cerevisiae S288C	25-29
29773647-2	2018	Erg25 is an iron-containing C4-methyl sterol oxidase that contributes to the conversion of 4,4-dimethylzymosterol to zymosterol, a precursor of ergosterol.	Ergosterol	144-154	methylsterol monooxygenase	Saccharomyces cerevisiae S288C	0-5
30374366-2	2018	Saccharomyces cerevisiae Pdr18 was proposed to transport ergosterol at the plasma membrane, contributing to the maintenance of adequate ergosterol content and decreased levels of stress-induced membrane disorganization and permeabilization under multistress challenge leading to resistance to ethanol, acetic acid and the herbicide 2,4-D, among other compounds.	Ergosterol	57-67	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	25-30
30374366-2	2018	Saccharomyces cerevisiae Pdr18 was proposed to transport ergosterol at the plasma membrane, contributing to the maintenance of adequate ergosterol content and decreased levels of stress-induced membrane disorganization and permeabilization under multistress challenge leading to resistance to ethanol, acetic acid and the herbicide 2,4-D, among other compounds.	Ergosterol	136-146	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	25-30
29968517-0	2018	Ergosterol and its derivatives from Grifola frondosa inhibit antigen-induced degranulation of RBL-2H3 cells by suppressing the aggregation of high affinity IgE receptors.	Ergosterol	0-10	RB transcriptional corepressor like 2	Rattus norvegicus	94-99
30076924-3	2018	Coruscanone A analogues, natural derivatives which target the fungal lanosterol enzyme, were docked against lanosterol 14 alpha-demethylase (CYP51A1) that converts lanosterol to 4,4-dimethylcholesta-8,14,24-trien-3beta-ol in the ergosterol biosynthesis pathway in order to stabilize the plasma membrane of the fungal species, and hence can be targeted for an effective antifungal therapy.	Ergosterol	229-239	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	108-139
30076924-3	2018	Coruscanone A analogues, natural derivatives which target the fungal lanosterol enzyme, were docked against lanosterol 14 alpha-demethylase (CYP51A1) that converts lanosterol to 4,4-dimethylcholesta-8,14,24-trien-3beta-ol in the ergosterol biosynthesis pathway in order to stabilize the plasma membrane of the fungal species, and hence can be targeted for an effective antifungal therapy.	Ergosterol	229-239	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	141-148
30065091-6	2018	Since the mammalian sterol cholesterol triggers NLRP3-mediated pyroptosis, we hypothesized that ergosterol may also do so.	Ergosterol	96-106	NLR family pyrin domain containing 3	Homo sapiens	48-53
30065091-8	2018	Cell wall mannoproteins directly bind ergosterol, and we found that Dan1, an ergosterol receptor mannoprotein, as well as specific mannosyltransferases, is required for pyroptosis, suggesting that cell wall-associated ergosterol may mediate the process.	Ergosterol	38-48	Dan1p	Saccharomyces cerevisiae S288C	68-72
30065091-8	2018	Cell wall mannoproteins directly bind ergosterol, and we found that Dan1, an ergosterol receptor mannoprotein, as well as specific mannosyltransferases, is required for pyroptosis, suggesting that cell wall-associated ergosterol may mediate the process.	Ergosterol	77-87	Dan1p	Saccharomyces cerevisiae S288C	68-72
29773647-3	2018	The ERG29 gene encodes an endoplasmic reticulum (ER)-associated protein, and here we identified a role for Erg29 in the methyl sterol oxidase step of ergosterol synthesis.	Ergosterol	150-160	Erg29p	Saccharomyces cerevisiae S288C	4-9
29773647-3	2018	The ERG29 gene encodes an endoplasmic reticulum (ER)-associated protein, and here we identified a role for Erg29 in the methyl sterol oxidase step of ergosterol synthesis.	Ergosterol	150-160	Erg29p	Saccharomyces cerevisiae S288C	107-112
29777118-0	2018	Pdr18 is involved in yeast response to acetic acid stress counteracting the decrease of plasma membrane ergosterol content and order.	Ergosterol	104-114	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	0-5
29775232-3	2018	In this study, we screened for multicopy suppressor genes that rescue the defect in CWI in cells lacking MIPC synthases (Sur1 and Csh1), and found that the defect is partly suppressed by upregulation of ergosterol biosynthesis.	Ergosterol	203-213	mannosylinositol phosphorylceramide synthase catalytic subunit SUR1	Saccharomyces cerevisiae S288C	121-125
29775232-3	2018	In this study, we screened for multicopy suppressor genes that rescue the defect in CWI in cells lacking MIPC synthases (Sur1 and Csh1), and found that the defect is partly suppressed by upregulation of ergosterol biosynthesis.	Ergosterol	203-213	mannosylinositol phosphorylceramide synthase catalytic subunit CSH1	Saccharomyces cerevisiae S288C	130-134
29775232-4	2018	In addition, repression of expression of ERG9, which encodes squalene synthase in the ergosterol biosynthesis pathway, in sur1  csh1  cells caused a strong growth defect and enhancement of the defect in CWI.	Ergosterol	86-96	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	41-45
29775232-4	2018	In addition, repression of expression of ERG9, which encodes squalene synthase in the ergosterol biosynthesis pathway, in sur1  csh1  cells caused a strong growth defect and enhancement of the defect in CWI.	Ergosterol	86-96	mannosylinositol phosphorylceramide synthase catalytic subunit SUR1	Saccharomyces cerevisiae S288C	122-126
29775232-4	2018	In addition, repression of expression of ERG9, which encodes squalene synthase in the ergosterol biosynthesis pathway, in sur1  csh1  cells caused a strong growth defect and enhancement of the defect in CWI.	Ergosterol	86-96	mannosylinositol phosphorylceramide synthase catalytic subunit CSH1	Saccharomyces cerevisiae S288C	128-132
29777118-6	2018	Collectively, our results support the notion that Pdr18-mediated multistress resistance is closely linked to the status of plasma membrane lipid environment related with ergosterol content and the associated plasma membrane properties.	Ergosterol	170-180	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	50-55
29500884-4	2018	Here we demonstrate results that display moderate to significant GFP-Snc1 recycling defects upon overexpression or inactivation of phospholipid, ergosterol, and sphingolipid biosynthesis enzymes, indicating that the homeostasis of membrane lipid levels is prerequisite for proper protein recycling.	Ergosterol	145-155	SNAP receptor SNC1	Saccharomyces cerevisiae S288C	69-73
29452159-0	2018	CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites.	Ergosterol	49-59	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-7
29777118-3	2018	This study provides new insights into the biological role and impact in yeast response to acetic acid stress of the multistress resistance determinant Pdr18 proposed to mediate ergosterol incorporation in plasma membrane.	Ergosterol	177-187	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	151-156
29777118-4	2018	The described coordinated activation of the transcription of PDR18 and of several ergosterol biosynthetic genes (ERG2-4, ERG6, ERG24) during the period of adaptation to acetic acid inhibited growth provides further support to the involvement of Pdr18 in yeast response to maintain plasma membrane ergosterol content in stressed cells.	Ergosterol	82-92	delta(14)-sterol reductase	Saccharomyces cerevisiae S288C	113-119
29777118-4	2018	The described coordinated activation of the transcription of PDR18 and of several ergosterol biosynthetic genes (ERG2-4, ERG6, ERG24) during the period of adaptation to acetic acid inhibited growth provides further support to the involvement of Pdr18 in yeast response to maintain plasma membrane ergosterol content in stressed cells.	Ergosterol	82-92	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	121-125
29777118-4	2018	The described coordinated activation of the transcription of PDR18 and of several ergosterol biosynthetic genes (ERG2-4, ERG6, ERG24) during the period of adaptation to acetic acid inhibited growth provides further support to the involvement of Pdr18 in yeast response to maintain plasma membrane ergosterol content in stressed cells.	Ergosterol	82-92	delta(14)-sterol reductase	Saccharomyces cerevisiae S288C	127-132
29777118-4	2018	The described coordinated activation of the transcription of PDR18 and of several ergosterol biosynthetic genes (ERG2-4, ERG6, ERG24) during the period of adaptation to acetic acid inhibited growth provides further support to the involvement of Pdr18 in yeast response to maintain plasma membrane ergosterol content in stressed cells.	Ergosterol	82-92	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	245-250
29777118-4	2018	The described coordinated activation of the transcription of PDR18 and of several ergosterol biosynthetic genes (ERG2-4, ERG6, ERG24) during the period of adaptation to acetic acid inhibited growth provides further support to the involvement of Pdr18 in yeast response to maintain plasma membrane ergosterol content in stressed cells.	Ergosterol	297-307	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	61-66
29777118-4	2018	The described coordinated activation of the transcription of PDR18 and of several ergosterol biosynthetic genes (ERG2-4, ERG6, ERG24) during the period of adaptation to acetic acid inhibited growth provides further support to the involvement of Pdr18 in yeast response to maintain plasma membrane ergosterol content in stressed cells.	Ergosterol	297-307	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	245-250
29777118-5	2018	Pdr18 role in ergosterol homeostasis helps the cell to counteract acetic acid-induced decrease of plasma membrane lipid order, increase of the non-specific membrane permeability and decrease of transmembrane electrochemical potential.	Ergosterol	14-24	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	0-5
29702647-4	2018	Loss-of-function mutations in the ergosterol biosynthetic gene ERG3 mitigate azole toxicity and enable resistance that depends upon fungal stress responses.	Ergosterol	34-44	C-5 sterol desaturase	Saccharomyces cerevisiae S288C	63-67
29319811-0	2018	Identification of a consensus motif in Erg28p required for C-4 demethylation in yeast ergosterol biosynthesis based on mutation analysis.	Ergosterol	86-96	Erg28p	Saccharomyces cerevisiae S288C	39-45
29594560-7	2018	Compared with an obviously enhanced yield of ergosterol in the wild-type strain, decreases of both the ergosta-5,7-dienol levels and the total sterol yield were found in Deltaerg5-upc2-1, probably due to the unbalanced NADH/NAD+ ratio observed in the erg5 knockouts, suggesting the whole-cell redox homeostasis was also vital for end-product biosynthesis.	Ergosterol	45-55	C-22 sterol desaturase	Saccharomyces cerevisiae S288C	175-179
29319811-6	2018	Complementation of the BY4741/erg28 strain with the ScERG28Delta175-204 plasmid resulted both in a significant growth inhibition and a reduction of ergosterol biosynthesis compared with the plasmid without the Delta175-204 truncation.	Ergosterol	148-158	Erg28p	Saccharomyces cerevisiae S288C	30-35
29319811-8	2018	Taken together, the data indicate that the region spanning amino acids 63-72 constitutes a key consensus motif within Erg28p that is required for sterol C-4 demethylation during ergosterol biosynthesis in S. cerevisiae.	Ergosterol	178-188	Erg28p	Saccharomyces cerevisiae S288C	118-124
29515531-5	2018	The balance between ergosterol and 14alpha-methyl sterols mediated by NSG2 plays an important role in C. albicans responding to azoles in vitro as well as in vivo.	Ergosterol	20-30	Nsg2p	Saccharomyces cerevisiae S288C	70-74
28599848-6	2018	Oligomerization of an amyloidogenic islet amyloid polypeptide (IAPP, or also known as amylin) resulting from its aggregation in a membrane environment, molecular interactions of the antifungal natural product amphotericin B with ergosterol in lipid bilayers, and the mechanism of lipid raft formation by sphingomyelin studied using solid state NMR methods are also discussed in this review article.	Ergosterol	229-239	islet amyloid polypeptide	Homo sapiens	86-92
28599848-6	2018	Oligomerization of an amyloidogenic islet amyloid polypeptide (IAPP, or also known as amylin) resulting from its aggregation in a membrane environment, molecular interactions of the antifungal natural product amphotericin B with ergosterol in lipid bilayers, and the mechanism of lipid raft formation by sphingomyelin studied using solid state NMR methods are also discussed in this review article.	Ergosterol	229-239	islet amyloid polypeptide	Homo sapiens	63-67
28720726-3	2017	Instead, we show that the increased dosage of Mge1 plays a protective role by retaining increased amounts of ergosterol upon fluconazole treatment.	Ergosterol	109-119	Mge1p	Saccharomyces cerevisiae S288C	46-50
29339490-4	2018	Here, we determined the crystal structures of the yeast Lam6 pleckstrin homology (PH)-like domain and the SDs of Lam2 and Lam4 in the apo form and in complex with ergosterol.	Ergosterol	163-173	Ysp2p	Saccharomyces cerevisiae S288C	113-117
29339490-4	2018	Here, we determined the crystal structures of the yeast Lam6 pleckstrin homology (PH)-like domain and the SDs of Lam2 and Lam4 in the apo form and in complex with ergosterol.	Ergosterol	163-173	Lam4p	Saccharomyces cerevisiae S288C	122-126
29329531-12	2018	Deletion of PAD1 and FDC1 conferred GVL resistance to a xylose-fermenting yeast strain by increasing ergosterol accumulation in aerobically grown cells.	Ergosterol	101-111	phenylacrylic acid decarboxylase PAD1	Saccharomyces cerevisiae S288C	12-16
29329531-12	2018	Deletion of PAD1 and FDC1 conferred GVL resistance to a xylose-fermenting yeast strain by increasing ergosterol accumulation in aerobically grown cells.	Ergosterol	101-111	putative phenylacrylic acid decarboxylase FDC1	Saccharomyces cerevisiae S288C	21-25
28741954-1	2017	A series of stigmasterol and ergosterol derivatives, characterized by the presence of oxygenated functions at C-22 and/or C-23 positions, were designed as potential liver X receptor (LXR) agonists.	Ergosterol	29-39	nucleolin	Homo sapiens	122-126
30663547-2	2018	Posaconazole is an orally administered second-generation triazole antifungal agent which inhibits lanosterol 14-alpha-demethylase, an enzyme that converts lanosterol to ergosterol, a vital component of the fungal cell membrane.	Ergosterol	169-179	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	98-129
28251448-0	2017	Effects of Ergosterol on COPD in Mice via JAK3/STAT3/NF-kappaB Pathway.	Ergosterol	11-21	Janus kinase 3	Mus musculus	42-46
28395217-7	2017	Finally, we demonstrated with our best derivative that the mechanism of action of our compounds is the inhibition of the sterol 14alpha-demethylase enzyme involved in ergosterol biosynthesis.	Ergosterol	167-177	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	121-147
28251448-0	2017	Effects of Ergosterol on COPD in Mice via JAK3/STAT3/NF-kappaB Pathway.	Ergosterol	11-21	signal transducer and activator of transcription 3	Mus musculus	47-52
28251448-0	2017	Effects of Ergosterol on COPD in Mice via JAK3/STAT3/NF-kappaB Pathway.	Ergosterol	11-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	53-62
28319008-3	2017	In this study, we determined the structures of the ankyrin repeat domain (ANK), and OSBP-related domain (ORD) of Osh1, in complex with Nvj1 and ergosterol, respectively.	Ergosterol	144-154	oxysterol-binding protein related protein SWH1	Saccharomyces cerevisiae S288C	113-117
28319008-5	2017	We discovered that Osh1 ORD binds ergosterol and phosphatidylinositol 4-phosphate PI(4)P in a competitive manner, suggesting counter-transport function of the two lipids.	Ergosterol	34-44	oxysterol-binding protein related protein SWH1	Saccharomyces cerevisiae S288C	19-23
28319008-6	2017	Ergosterol is bound to the hydrophobic pocket in a head-down orientation, and the structure of the PI(4)P-binding site in Osh1 is well conserved.	Ergosterol	0-10	oxysterol-binding protein related protein SWH1	Saccharomyces cerevisiae S288C	122-126
28319008-7	2017	Our results suggest that Osh1 performs non-vesicular transport of ergosterol and PI(4)P at the NVJ.	Ergosterol	66-76	oxysterol-binding protein related protein SWH1	Saccharomyces cerevisiae S288C	25-29
27956494-12	2017	SCH9 deletion downregulated the amount of most proteinogenic amino acids and increased the amount of lipids, such as ergosterol.	Ergosterol	117-127	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	0-4
27907120-1	2016	Azole antifungals, known as demethylase inhibitors (DMIs), target sterol 14alpha-demethylase (CYP51) in the ergosterol biosynthetic pathway of fungal pathogens of both plants and humans.	Ergosterol	108-118	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	66-92
27859799-3	2016	Resistance to the commonly used azole fungicides is thought to be driven mainly by mutations in a gene (CYP51) encoding a protein of the ergosterol biosynthesis pathway.	Ergosterol	137-147	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	104-109
27907120-1	2016	Azole antifungals, known as demethylase inhibitors (DMIs), target sterol 14alpha-demethylase (CYP51) in the ergosterol biosynthetic pathway of fungal pathogens of both plants and humans.	Ergosterol	108-118	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	94-99
27761133-6	2016	At the transcriptional level, Aha1, Sti1, and P23 positively regulate responses to ketoconazole stress by erg11 and erg6, key genes in the ergosterol biosynthetic pathway.	Ergosterol	139-149	Aha1p	Saccharomyces cerevisiae S288C	30-34
27656110-6	2016	A lipidomic analysis revealed that Acsl suppressed the levels of three lipid raft components in the brain, including mannosyl glucosylceramide (MacCer), phosphoethanolamine ceramide and ergosterol.	Ergosterol	186-196	Acyl-CoA synthetase long-chain	Drosophila melanogaster	35-39
27761133-6	2016	At the transcriptional level, Aha1, Sti1, and P23 positively regulate responses to ketoconazole stress by erg11 and erg6, key genes in the ergosterol biosynthetic pathway.	Ergosterol	139-149	Hsp90 cochaperone STI1	Saccharomyces cerevisiae S288C	36-40
27761133-6	2016	At the transcriptional level, Aha1, Sti1, and P23 positively regulate responses to ketoconazole stress by erg11 and erg6, key genes in the ergosterol biosynthetic pathway.	Ergosterol	139-149	sterol 14-demethylase	Saccharomyces cerevisiae S288C	106-111
27761133-6	2016	At the transcriptional level, Aha1, Sti1, and P23 positively regulate responses to ketoconazole stress by erg11 and erg6, key genes in the ergosterol biosynthetic pathway.	Ergosterol	139-149	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	116-120
27161631-6	2016	Finally, the cellular mode of action for VT-1129 was confirmed to be CYP51 inhibition, resulting in the depletion of ergosterol and ergosta-7-enol and the accumulation of eburicol, obtusifolione, and lanosterol/obtusifoliol in the cell membranes.	Ergosterol	117-127	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	69-74
27697142-13	2016	Echinocandin resistance was induced by the well-known S645P variant of FKS1 and polyene resistance was likely inflicted by a frameshift mutation in ERG2 leading to loss of function of the encoded protein and subsequent ergosterol depletion.	Ergosterol	219-229	potassium voltage-gated channel subfamily H member 6	Homo sapiens	148-152
27216456-0	2016	Lipid droplet proteins, Lds1p, Lds2p, and Rrt8p, are implicated in membrane protein transport associated with ergosterol.	Ergosterol	110-120	Lds1p	Saccharomyces cerevisiae S288C	24-29
27438727-5	2016	We show that the CBC acts complementary to SrbA as a negative regulator of ergosterol biosynthesis and show that lack of CBC activity results in increased sterol levels via transcriptional derepression of multiple ergosterol biosynthetic genes including those coding for HMG-CoA-synthase, HMG-CoA-reductase and sterol C14-demethylase.	Ergosterol	75-85	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	289-306
27216456-0	2016	Lipid droplet proteins, Lds1p, Lds2p, and Rrt8p, are implicated in membrane protein transport associated with ergosterol.	Ergosterol	110-120	Lds2p	Saccharomyces cerevisiae S288C	31-36
27216456-0	2016	Lipid droplet proteins, Lds1p, Lds2p, and Rrt8p, are implicated in membrane protein transport associated with ergosterol.	Ergosterol	110-120	Rrt8p	Saccharomyces cerevisiae S288C	42-47
27216456-6	2016	We also demonstrated that lack of these proteins partially suppressed the growth defect and mis-sorting of the high-affinity tryptophan transporter Tat2p, induced by impairment of ergosterol biosynthesis.	Ergosterol	180-190	aromatic amino acid transmembrane transporter TAT2	Saccharomyces cerevisiae S288C	148-153
27113535-1	2016	Mevalonate kinase (MVK) is an essential enzyme acting in early steps of sterol isoprenoids biosynthesis, such as cholesterol in humans or ergosterol in trypanosomatids.	Ergosterol	138-148	mevalonate kinase	Homo sapiens	0-17
27133301-7	2016	NPs/Erg exerted much stronger cytotoxicity against human cancer cells than the free ergosterol, and showed significantly reduced IC50 values (14.69+-0.48 mug/mL in glioma U251 cells; 9.43+-0.52 mug/mL in breast cancer MCF-7 cells; 4.70+-0.41 mug/mL in hepatoma HepG2 cells).	Ergosterol	84-94	ETS transcription factor ERG	Homo sapiens	4-7
27133301-8	2016	After oral administration of a single dose in rats, NPs/Erg displayed a prolonged plasma circulation with a 4.9-fold increase of oral bioavailability compared with the free ergosterol.	Ergosterol	173-183	ETS transcription factor ERG	Rattus norvegicus	56-59
27133301-9	2016	After mice received NPs/Erg, the ergosterol in NPs/Erg was rapidly distributed in stomach, kidneys, liver, brain, spleen, and virtually non-existent in heart and lungs.	Ergosterol	33-43	ETS transcription factor	Mus musculus	24-27
27133301-9	2016	After mice received NPs/Erg, the ergosterol in NPs/Erg was rapidly distributed in stomach, kidneys, liver, brain, spleen, and virtually non-existent in heart and lungs.	Ergosterol	33-43	ETS transcription factor	Mus musculus	51-54
26891232-0	2016	Human CYP27A1 catalyzes hydroxylation of beta-sitosterol and ergosterol.	Ergosterol	61-71	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	6-13
27162362-3	2016	A mammalian analog of ergosterol, 7-dehydrocholesterol (7-DHC), accumulates in Smith-Lemli-Opitz syndrome, a human genetic disease that phenocopies deficient Hedgehog signaling and is caused by genetic loss of 7-DHC reductase.	Ergosterol	22-32	7-dehydrocholesterol reductase	Homo sapiens	210-225
27113535-1	2016	Mevalonate kinase (MVK) is an essential enzyme acting in early steps of sterol isoprenoids biosynthesis, such as cholesterol in humans or ergosterol in trypanosomatids.	Ergosterol	138-148	mevalonate kinase	Homo sapiens	19-22
27038795-8	2016	The ergosterol synthesis regulator/enzyme-scaffold gene ERG28 probably contributes by sensing a congested environment, because growth of erg28Delta strain was unaffected by the presence of donor bacterial cells, while the growth of the wild-type and other mutant yeast strains was suppressed by their presence.	Ergosterol	4-14	ergosterol biosynthesis 28 homolog	Homo sapiens	56-61
27040153-4	2016	This study was designed to evaluate the effects of ergosterol on RAGE signaling in HSC-T6 cells.	Ergosterol	51-61	advanced glycosylation end product-specific receptor	Rattus norvegicus	65-69
25948514-12	2016	Addition of SFE or ergosterol induced in jejunum a similar transcriptional response to simvastatin and ezetimibe; they all down-regulated Srebf2 and Nr1h4 (FXR) genes.	Ergosterol	19-29	sterol regulatory element binding transcription factor 2	Homo sapiens	138-144
25948514-12	2016	Addition of SFE or ergosterol induced in jejunum a similar transcriptional response to simvastatin and ezetimibe; they all down-regulated Srebf2 and Nr1h4 (FXR) genes.	Ergosterol	19-29	nuclear receptor subfamily 1 group H member 4	Homo sapiens	149-154
25948514-12	2016	Addition of SFE or ergosterol induced in jejunum a similar transcriptional response to simvastatin and ezetimibe; they all down-regulated Srebf2 and Nr1h4 (FXR) genes.	Ergosterol	19-29	nuclear receptor subfamily 1 group H member 4	Homo sapiens	156-159
27040153-0	2016	The anti-hepatic fibrosis activity of ergosterol depended on upregulation of PPARgamma in HSC-T6 cells.	Ergosterol	38-48	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	77-86
27040153-5	2016	Ergosterol suppressed the activation of HSC-T6 cells induced by AGEs, and attenuated overexpressions of alpha-SMA, MMP-9, and epithelial-mesenchymal transition (EMT) markers, including N-cadherin and vimentin.	Ergosterol	0-10	actin gamma 2, smooth muscle	Rattus norvegicus	104-113
27040153-5	2016	Ergosterol suppressed the activation of HSC-T6 cells induced by AGEs, and attenuated overexpressions of alpha-SMA, MMP-9, and epithelial-mesenchymal transition (EMT) markers, including N-cadherin and vimentin.	Ergosterol	0-10	matrix metallopeptidase 9	Rattus norvegicus	115-120
27040153-5	2016	Ergosterol suppressed the activation of HSC-T6 cells induced by AGEs, and attenuated overexpressions of alpha-SMA, MMP-9, and epithelial-mesenchymal transition (EMT) markers, including N-cadherin and vimentin.	Ergosterol	0-10	cadherin 2	Rattus norvegicus	185-195
27040153-5	2016	Ergosterol suppressed the activation of HSC-T6 cells induced by AGEs, and attenuated overexpressions of alpha-SMA, MMP-9, and epithelial-mesenchymal transition (EMT) markers, including N-cadherin and vimentin.	Ergosterol	0-10	vimentin	Rattus norvegicus	200-208
27040153-6	2016	We also found that these inhibitory effects of ergosterol on the activation of HSCs were dependent on peroxisome proliferator-activated receptor-gamma (PPARgamma) confirmed by PPARgamma reporter assay and PPARgamma knockdown.	Ergosterol	47-57	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	102-150
27040153-6	2016	We also found that these inhibitory effects of ergosterol on the activation of HSCs were dependent on peroxisome proliferator-activated receptor-gamma (PPARgamma) confirmed by PPARgamma reporter assay and PPARgamma knockdown.	Ergosterol	47-57	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	152-161
27040153-6	2016	We also found that these inhibitory effects of ergosterol on the activation of HSCs were dependent on peroxisome proliferator-activated receptor-gamma (PPARgamma) confirmed by PPARgamma reporter assay and PPARgamma knockdown.	Ergosterol	47-57	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	176-185
27040153-6	2016	We also found that these inhibitory effects of ergosterol on the activation of HSCs were dependent on peroxisome proliferator-activated receptor-gamma (PPARgamma) confirmed by PPARgamma reporter assay and PPARgamma knockdown.	Ergosterol	47-57	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	176-185
26806515-0	2016	Impaired ergosterol biosynthesis mediated fungicidal activity of Co(II) complex with ligand derived from cinnamaldehyde.	Ergosterol	9-19	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	65-71
26806515-3	2016	Anticandidal activity of cinnamaldehyde its ligand [L] and Co(II) complex was investigated by determining MIC80, time-kill kinetics, disc diffusion assay and ergosterol extraction and estimation assay.	Ergosterol	158-168	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	59-65
26806515-5	2016	MIC80 of Co(II) complex correlated well with ergosterol inhibition suggesting ergosterol biosynthesis to be the primary site of action.	Ergosterol	45-55	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	9-15
26806515-5	2016	MIC80 of Co(II) complex correlated well with ergosterol inhibition suggesting ergosterol biosynthesis to be the primary site of action.	Ergosterol	78-88	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	9-15
26806515-10	2016	It was concluded that fungicidal activity of Co(II) complex originated from loss of membrane integrity and a decrease in ergosterol content is only one consequence of this.	Ergosterol	121-131	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	45-51
26908577-8	2016	Compared to the single Dap proteins found in Saccharomyces cerevisiae and Schizosaccharomyces pombe, we suggest that this complex Dap family regulatory system emerged during the evolution of fungi as an adaptive means to regulate ergosterol synthesis in response to environmental stimuli.	Ergosterol	230-240	death associated protein	Homo sapiens	23-26
26908577-8	2016	Compared to the single Dap proteins found in Saccharomyces cerevisiae and Schizosaccharomyces pombe, we suggest that this complex Dap family regulatory system emerged during the evolution of fungi as an adaptive means to regulate ergosterol synthesis in response to environmental stimuli.	Ergosterol	230-240	death associated protein	Homo sapiens	130-133
26908577-10	2016	In this study, we demonstrate that three cytochrome b5-like Dap proteins coordinately regulate the azole resistance and ergosterol biosynthesis catalyzed by cytochrome P450 proteins.	Ergosterol	120-130	death associated protein	Homo sapiens	60-63
26838333-5	2016	Nevertheless, Sey1p-dependent lipid mixing was strongly reduced by omitting three major acidic lipids from the ER-mimicking set and, moreover, was entirely abolished by omitting either phosphatidylethanolamine or ergosterol.	Ergosterol	213-223	dynamin-like GTPase SEY1	Saccharomyces cerevisiae S288C	14-19