PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33386501-0	2021	Protein mass spectrometry reveals lycorine exerting anti-multiple-myeloma effect by acting on VDAC2 and causing mitochondrial abnormalities.	lycorine	34-42	voltage dependent anion channel 2	Homo sapiens	94-99
33376043-6	2021	PURPOSE: We investigated the direct-inhibiting action of lycorine on CoV"s RdRp, as potential treatment for emerging CoV infections.	lycorine	57-65	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	75-79
34038839-0	2021	Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson"s disease models.	lycorine	0-8	synuclein, alpha	Mus musculus	58-73
34038839-3	2021	PURPOSE: To identify and investigate lycorine as a UPS enhancer able to decrease alpha-syn in transgenic PD models.	lycorine	37-45	synuclein, alpha	Mus musculus	81-90
34038839-6	2021	Heterozygous A53T transgenic mice were used to evaluate the effects of lycorine on alpha-syn degradation in vivo.	lycorine	71-79	synuclein, alpha	Mus musculus	83-92
34038839-10	2021	RESULTS: Lycorine significantly promoted clearance of over-expressed WT and mutant alpha-syn in neuronal cell lines and primary cultured neurons.	lycorine	9-17	synuclein, alpha	Mus musculus	83-92
34038839-11	2021	More importantly, 15 days" intraperitoneal administration of lycorine effectively promoted the degradation of alpha-syn in the brains of A53T transgenic mice.	lycorine	61-69	synuclein, alpha	Mus musculus	110-119
34038839-12	2021	Mechanistically, lycorine accelerated alpha-syn degradation by activating cAMP-dependent protein kinase (PKA) to promote proteasome activity.	lycorine	17-25	synuclein, alpha	Mus musculus	38-47
34038839-13	2021	CONCLUSION: Lycorine is a novel alpha-syn-lowering compound that works through PKA-mediated UPS activation.	lycorine	12-20	synuclein, alpha	Mus musculus	32-41
34038839-14	2021	This ability to lower alpha-syn implies that lycorine has the potential to be developed as a pharmaceutical for the treatment of neurodegenerative diseases, such as PD, associated with UPS impairment and protein aggregations.	lycorine	45-53	synuclein, alpha	Mus musculus	22-31
33856593-8	2021	Furthermore, the expression levels of several MAPK and GTPase coding genes were reduced upon the lycorine treatment.	lycorine	97-105	mitogen-activated protein kinase homolog D5	Malus domestica	46-50
33649853-0	2021	Lycorine inhibits cell proliferation, migration and invasion, and primarily exerts in vitro cytostatic effects in human colorectal cancer via activating the ROS/p38 and AKT signaling pathways.	lycorine	0-8	mitogen-activated protein kinase 14	Homo sapiens	161-164
33649853-0	2021	Lycorine inhibits cell proliferation, migration and invasion, and primarily exerts in vitro cytostatic effects in human colorectal cancer via activating the ROS/p38 and AKT signaling pathways.	lycorine	0-8	AKT serine/threonine kinase 1	Homo sapiens	169-172
33649853-8	2021	In LoVo cells, the protein expression levels of matrix metallopeptidases, snail family transcriptional repressor 1, Vimentin and N-cadherin were significantly downregulated, whereas the protein expression levels of E-cadherin were significantly upregulated by lycorine treatment compared with the control group.	lycorine	260-268	cadherin 1	Homo sapiens	215-225
33649853-11	2021	Furthermore, lycorine significantly downregulated the protein expression levels of cyclin D1 and cyclin E1, but significantly increased p21 and Smad4 protein expression levels in HCT116 and LoVo cells compared with the control group.	lycorine	13-21	cyclin D1	Homo sapiens	83-92
33649853-11	2021	Furthermore, lycorine significantly downregulated the protein expression levels of cyclin D1 and cyclin E1, but significantly increased p21 and Smad4 protein expression levels in HCT116 and LoVo cells compared with the control group.	lycorine	13-21	cyclin E1	Homo sapiens	97-106
33649853-11	2021	Furthermore, lycorine significantly downregulated the protein expression levels of cyclin D1 and cyclin E1, but significantly increased p21 and Smad4 protein expression levels in HCT116 and LoVo cells compared with the control group.	lycorine	13-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	136-139
33649853-11	2021	Furthermore, lycorine significantly downregulated the protein expression levels of cyclin D1 and cyclin E1, but significantly increased p21 and Smad4 protein expression levels in HCT116 and LoVo cells compared with the control group.	lycorine	13-21	SMAD family member 4	Homo sapiens	144-149
33649853-12	2021	The intracellular reactive oxygen species (ROS) measurement results also indicated that compared with the control group, lycorine significantly induced ROS accumulation, and increased phosphorylated-p38 expression levels and AKT phosphorylation.	lycorine	121-129	mitogen-activated protein kinase 14	Homo sapiens	199-202
33649853-12	2021	The intracellular reactive oxygen species (ROS) measurement results also indicated that compared with the control group, lycorine significantly induced ROS accumulation, and increased phosphorylated-p38 expression levels and AKT phosphorylation.	lycorine	121-129	AKT serine/threonine kinase 1	Homo sapiens	225-228
33649853-13	2021	Collectively, the present study suggested that lycorine might induce cell cycle arrest and exert cytostatic effects potentially via activating ROS/p38 and AKT signaling pathways in CRC cells.	lycorine	47-55	mitogen-activated protein kinase 14	Homo sapiens	147-150
33649853-13	2021	Collectively, the present study suggested that lycorine might induce cell cycle arrest and exert cytostatic effects potentially via activating ROS/p38 and AKT signaling pathways in CRC cells.	lycorine	47-55	AKT serine/threonine kinase 1	Homo sapiens	155-158
33376043-12	2021	CONCLUSIONS: Lycorine is a potent non-nucleoside direct-acting antiviral against emerging coronavirus infections and acts by inhibiting viral RdRp activity; therefore, lycorine may be a candidate against the current COVID-19 pandemic.	lycorine	13-21	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	142-146
33376043-12	2021	CONCLUSIONS: Lycorine is a potent non-nucleoside direct-acting antiviral against emerging coronavirus infections and acts by inhibiting viral RdRp activity; therefore, lycorine may be a candidate against the current COVID-19 pandemic.	lycorine	168-176	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	142-146
33386501-3	2021	Voltage-dependent anion-selective channel protein 2 (VDAC2), the most abundant protein in the outer mitochondrial membrane, was up-regulated after treatment with lycorine and was subsequently verified by western blot analysis.	lycorine	162-170	voltage dependent anion channel 2	Homo sapiens	0-51
33386501-3	2021	Voltage-dependent anion-selective channel protein 2 (VDAC2), the most abundant protein in the outer mitochondrial membrane, was up-regulated after treatment with lycorine and was subsequently verified by western blot analysis.	lycorine	162-170	voltage dependent anion channel 2	Homo sapiens	53-58
33386501-5	2021	CONCLUSIONS: Lycorine can achieve the effect of resisting multiple myeloma by acting on VDAC2 and causing mitochondrial abnormalities.	lycorine	13-21	voltage dependent anion channel 2	Homo sapiens	88-93
33455051-4	2021	Here, we demonstrate that the salt of lycorine, lycorine hydrochloride, significantly suppressed stress-induced premature cellular senescence (SIPS) by ~2-fold, as determined by senescence-associated beta-galactosidase (SA-beta-gal) staining and the expression of p16 and p21.	lycorine	38-46	cyclin dependent kinase inhibitor 2A	Homo sapiens	264-267
33455051-4	2021	Here, we demonstrate that the salt of lycorine, lycorine hydrochloride, significantly suppressed stress-induced premature cellular senescence (SIPS) by ~2-fold, as determined by senescence-associated beta-galactosidase (SA-beta-gal) staining and the expression of p16 and p21.	lycorine	38-46	H3 histone pseudogene 16	Homo sapiens	272-275
32565130-2	2020	HLY78, a lycorine derivative, has been identified as a novel activator of Wnt/beta-catenin signaling in vitro.	lycorine	9-17	catenin beta 1	Rattus norvegicus	78-90
33042426-0	2020	Lycorine inhibits tumor growth of human osteosarcoma cells by blocking Wnt/beta-catenin, ERK1/2/MAPK and PI3K/AKT signaling pathway.	lycorine	0-8	catenin beta 1	Homo sapiens	75-87
33042426-0	2020	Lycorine inhibits tumor growth of human osteosarcoma cells by blocking Wnt/beta-catenin, ERK1/2/MAPK and PI3K/AKT signaling pathway.	lycorine	0-8	mitogen-activated protein kinase 3	Homo sapiens	89-95
33042426-0	2020	Lycorine inhibits tumor growth of human osteosarcoma cells by blocking Wnt/beta-catenin, ERK1/2/MAPK and PI3K/AKT signaling pathway.	lycorine	0-8	AKT serine/threonine kinase 1	Homo sapiens	110-113
33042426-8	2020	Mechanically, lycorine reduced the protein level of beta-catenin and its" downstream molecule c-Myc.	lycorine	14-22	catenin beta 1	Homo sapiens	52-64
33042426-8	2020	Mechanically, lycorine reduced the protein level of beta-catenin and its" downstream molecule c-Myc.	lycorine	14-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
33042426-9	2020	Furthermore, lycorine also decreased the phosphorylation of ERK1/2 and AKT.	lycorine	13-21	mitogen-activated protein kinase 3	Homo sapiens	60-66
33042426-9	2020	Furthermore, lycorine also decreased the phosphorylation of ERK1/2 and AKT.	lycorine	13-21	AKT serine/threonine kinase 1	Homo sapiens	71-74
33042426-10	2020	Together, our results reveal that lycorine may inhibit tumor growth of OS cells possibly through suppressing Wnt/beta-catenin, ERK1/2 and PI3K/AKT signaling pathway.	lycorine	34-42	catenin beta 1	Homo sapiens	113-125
33042426-10	2020	Together, our results reveal that lycorine may inhibit tumor growth of OS cells possibly through suppressing Wnt/beta-catenin, ERK1/2 and PI3K/AKT signaling pathway.	lycorine	34-42	mitogen-activated protein kinase 3	Homo sapiens	127-133
33042426-10	2020	Together, our results reveal that lycorine may inhibit tumor growth of OS cells possibly through suppressing Wnt/beta-catenin, ERK1/2 and PI3K/AKT signaling pathway.	lycorine	34-42	AKT serine/threonine kinase 1	Homo sapiens	143-146
32818131-0	2020	Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-kappaB pathway.	lycorine	0-8	high mobility group box 1	Mus musculus	77-82
32823854-3	2020	In vivo (rodent) experiments proved cardiac anti-fibrotic effects of the natural compounds bufalin and lycorine by downregulating miRNA-671-5p, associated with a theoretic increase in the tissue level of circRNA CDR1as.	lycorine	103-111	CDR1 antisense RNA	Homo sapiens	212-218
32818131-0	2020	Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-kappaB pathway.	lycorine	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97
32818131-6	2020	Our results showed that after LPS treatment, the lung injury score, lung wet-to-dry weight ratio, and malondialdehyde (MDA) production in the lung tissues and the expression levels of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in bronchoalveolar lavage fluid were significantly increased, whereas their levels were decreased by lycorine.	lycorine	351-359	tumor necrosis factor	Mus musculus	184-211
32818131-8	2020	However, lycorine treatment attenuated the activity of the HMGB1/TLRs/NF-kappaB pathway in the lung tissues.	lycorine	9-17	high mobility group box 1	Mus musculus	59-64
32818131-8	2020	However, lycorine treatment attenuated the activity of the HMGB1/TLRs/NF-kappaB pathway in the lung tissues.	lycorine	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	70-79
32818131-9	2020	In vitro studies showed that lycorine administration significantly decreased the levels of inflammatory cytokines and MDA and attenuated the activity of the HMGB1/TLRs/NF-kappaB pathway in LPS-treated cells.	lycorine	29-37	high mobility group box 1	Mus musculus	157-162
32818131-9	2020	In vitro studies showed that lycorine administration significantly decreased the levels of inflammatory cytokines and MDA and attenuated the activity of the HMGB1/TLRs/NF-kappaB pathway in LPS-treated cells.	lycorine	29-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	168-177
32818131-11	2020	We suggest that lycorine could alleviate LPS-induced lung injury of inflammation and oxidative stress by blocking the HMGB1/TLRs/NF-kappaB pathway, which gives a new perspective for ALI therapy to treat lycorine as a potential treatment clinically.	lycorine	16-24	high mobility group box 1	Mus musculus	118-123
32818131-11	2020	We suggest that lycorine could alleviate LPS-induced lung injury of inflammation and oxidative stress by blocking the HMGB1/TLRs/NF-kappaB pathway, which gives a new perspective for ALI therapy to treat lycorine as a potential treatment clinically.	lycorine	16-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	129-138
32818131-11	2020	We suggest that lycorine could alleviate LPS-induced lung injury of inflammation and oxidative stress by blocking the HMGB1/TLRs/NF-kappaB pathway, which gives a new perspective for ALI therapy to treat lycorine as a potential treatment clinically.	lycorine	203-211	high mobility group box 1	Mus musculus	118-123
32818131-11	2020	We suggest that lycorine could alleviate LPS-induced lung injury of inflammation and oxidative stress by blocking the HMGB1/TLRs/NF-kappaB pathway, which gives a new perspective for ALI therapy to treat lycorine as a potential treatment clinically.	lycorine	203-211	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	129-138
32439835-0	2020	Correction of the tumor suppressor Salvador homolog-1 deficiency in tumors by lycorine as a new strategy in lung cancer therapy.	lycorine	78-86	salvador family WW domain containing protein 1	Homo sapiens	35-53
32167591-0	2020	Lycorine targets multiple myeloma stem cell-like cells by inhibition of Wnt/beta-catenin pathway.	lycorine	0-8	catenin beta 1	Homo sapiens	76-88
32167591-5	2020	Here we showed that lycorine, a natural compound from the Amaryllidaceae species, effectively inhibits the proliferation of myeloma cells from cell lines or patients, mainly through decreasing ALDH1+ cells.	lycorine	20-28	aldehyde dehydrogenase 1 family member A1	Homo sapiens	193-198
32167591-6	2020	Mechanistically, lycorine decreases the MMSC population through inhibition of the Wnt/beta-catenin pathway by reducing the beta-catenin protein level.	lycorine	17-25	catenin beta 1	Homo sapiens	86-98
32167591-7	2020	Moreover, lycorine could overcome the increasing proportion of ALDH1+ cells caused by bortezomib (BTZ) treatment, and a combination BTZ and lycorine have a synergistic effect on anti-myeloma cells.	lycorine	10-18	aldehyde dehydrogenase 1 family member A1	Homo sapiens	63-68
32428667-0	2020	Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis.	lycorine	0-8	NLR family, pyrin domain containing 3	Mus musculus	73-78
32439835-5	2020	Here we found that the small molecule lycorine notably increased SAV1 levels in lung cancer cells by inhibiting SAV1 degradation via a ubiquitin-lysosome system, and inducing phosphorylation and activation of the SAV1-interacting protein mammalian Ste20-like 1 (MST1).	lycorine	38-46	salvador family WW domain containing protein 1	Homo sapiens	65-69
32439835-5	2020	Here we found that the small molecule lycorine notably increased SAV1 levels in lung cancer cells by inhibiting SAV1 degradation via a ubiquitin-lysosome system, and inducing phosphorylation and activation of the SAV1-interacting protein mammalian Ste20-like 1 (MST1).	lycorine	38-46	salvador family WW domain containing protein 1	Homo sapiens	112-116
32439835-5	2020	Here we found that the small molecule lycorine notably increased SAV1 levels in lung cancer cells by inhibiting SAV1 degradation via a ubiquitin-lysosome system, and inducing phosphorylation and activation of the SAV1-interacting protein mammalian Ste20-like 1 (MST1).	lycorine	38-46	salvador family WW domain containing protein 1	Homo sapiens	112-116
32439835-5	2020	Here we found that the small molecule lycorine notably increased SAV1 levels in lung cancer cells by inhibiting SAV1 degradation via a ubiquitin-lysosome system, and inducing phosphorylation and activation of the SAV1-interacting protein mammalian Ste20-like 1 (MST1).	lycorine	38-46	macrophage stimulating 1	Homo sapiens	262-266
32439835-7	2020	Strikingly, treating tumor-bearing xenograft mice with lycorine increased SAV1 levels, and strongly inhibited tumor growth, vasculogenic mimicry, and metastasis.	lycorine	55-63	salvador family WW domain containing 1	Mus musculus	74-78
32432943-3	2021	In this study, we identified a small molecule, lycorine, which binds to SCAP, which suppressed the SREBF pathway without inducing ER stress or activating NR1H3.	lycorine	47-55	SREBF chaperone	Mus musculus	72-76
31464976-0	2020	Lycorine Induces Apoptosis and G1 Phase Arrest Through ROS/p38 MAPK Signaling Pathway in Human Osteosarcoma cells in vitro and in vivo.	lycorine	0-8	mitogen-activated protein kinase 14	Homo sapiens	59-62
32432943-3	2021	In this study, we identified a small molecule, lycorine, which binds to SCAP, which suppressed the SREBF pathway without inducing ER stress or activating NR1H3.	lycorine	47-55	sterol regulatory element binding transcription factor 1	Mus musculus	99-104
32432943-3	2021	In this study, we identified a small molecule, lycorine, which binds to SCAP, which suppressed the SREBF pathway without inducing ER stress or activating NR1H3.	lycorine	47-55	nuclear receptor subfamily 1, group H, member 3	Mus musculus	154-159
32432943-4	2021	Mechanistically, lycorine promotes SCAP lysosomal degradation in a macroautophagy/autophagy-independent pathway, a mechanism completely distinct from current SCAP inhibitors.	lycorine	17-25	SREBF chaperone	Mus musculus	35-39
32432943-4	2021	Mechanistically, lycorine promotes SCAP lysosomal degradation in a macroautophagy/autophagy-independent pathway, a mechanism completely distinct from current SCAP inhibitors.	lycorine	17-25	SREBF chaperone	Mus musculus	158-162
32432943-7	2021	Interestingly, lycorine triggers the lysosome translocation of SCAP independent of autophagy.	lycorine	15-23	SREBF chaperone	Mus musculus	63-67
32244227-0	2020	Correction for: Lycorine induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer.	lycorine	16-24	mitogen-activated protein kinase kinase 2	Homo sapiens	77-81
31464976-8	2020	Inhibition of ROS generation by NAC or p38 MAPK signaling by SB203580 attenuated the p53-mediated cell cycle arrest and apoptosis induced by LY.	lycorine	141-143	mitogen-activated protein kinase 14	Homo sapiens	39-42
31464976-8	2020	Inhibition of ROS generation by NAC or p38 MAPK signaling by SB203580 attenuated the p53-mediated cell cycle arrest and apoptosis induced by LY.	lycorine	141-143	tumor protein p53	Homo sapiens	85-88
31176784-0	2019	Lycorine inhibited the cell growth of non-small cell lung cancer by modulating the miR-186/CDK1 axis.	lycorine	0-8	microRNA 186	Homo sapiens	83-90
31176784-0	2019	Lycorine inhibited the cell growth of non-small cell lung cancer by modulating the miR-186/CDK1 axis.	lycorine	0-8	cyclin dependent kinase 1	Homo sapiens	91-95
31176784-9	2019	Depletion of miR-186 significantly reversed the suppressive effect of lycorine on the proliferation of NSCLC cells.	lycorine	70-78	microRNA 186	Homo sapiens	13-20
31176784-12	2019	Consistently, exposure of lycorine significantly decreased the expression of CDK1.	lycorine	26-34	cyclin dependent kinase 1	Homo sapiens	77-81
31176784-13	2019	Restoration of CDK1 remarkably attenuated the inhibition of lycorine on the proliferation of NSCLC cells.	lycorine	60-68	cyclin dependent kinase 1	Homo sapiens	15-19
31176784-14	2019	SIGNIFICANCE: Our results uncovered the novel molecular mechanism of lycorine in suppressing the progression of NSCLC partially via regulating the miR-186/CDK1 axis.	lycorine	69-77	microRNA 186	Homo sapiens	147-154
31176784-14	2019	SIGNIFICANCE: Our results uncovered the novel molecular mechanism of lycorine in suppressing the progression of NSCLC partially via regulating the miR-186/CDK1 axis.	lycorine	69-77	cyclin dependent kinase 1	Homo sapiens	155-159
31263414-0	2019	Lycorine Induces Mitochondria-Dependent Apoptosis in Hepatoblastoma HepG2 Cells Through ROCK1 Activation.	lycorine	0-8	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	88-93
30565685-0	2019	Lycorine inhibits melanoma cell migration and metastasis mainly through reducing intracellular levels of beta-catenin and matrix metallopeptidase 9.	lycorine	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	105-117
30565685-0	2019	Lycorine inhibits melanoma cell migration and metastasis mainly through reducing intracellular levels of beta-catenin and matrix metallopeptidase 9.	lycorine	0-8	matrix metallopeptidase 9	Mus musculus	122-147
30565685-4	2019	Molecular mechanistic studies revealed that lycorine significantly reduced intracellular levels of beta-catenin protein through degradation of the protein via the ubiquitin-proteasome pathway, and decreased the expression of beta-catenin downstream prometastatic matrix metallopeptidase 9 and Axin2 genes.	lycorine	44-52	catenin (cadherin associated protein), beta 1	Mus musculus	99-111
30565685-4	2019	Molecular mechanistic studies revealed that lycorine significantly reduced intracellular levels of beta-catenin protein through degradation of the protein via the ubiquitin-proteasome pathway, and decreased the expression of beta-catenin downstream prometastatic matrix metallopeptidase 9 and Axin2 genes.	lycorine	44-52	catenin (cadherin associated protein), beta 1	Mus musculus	225-237
30565685-4	2019	Molecular mechanistic studies revealed that lycorine significantly reduced intracellular levels of beta-catenin protein through degradation of the protein via the ubiquitin-proteasome pathway, and decreased the expression of beta-catenin downstream prometastatic matrix metallopeptidase 9 and Axin2 genes.	lycorine	44-52	matrix metallopeptidase 9	Mus musculus	263-288
30565685-4	2019	Molecular mechanistic studies revealed that lycorine significantly reduced intracellular levels of beta-catenin protein through degradation of the protein via the ubiquitin-proteasome pathway, and decreased the expression of beta-catenin downstream prometastatic matrix metallopeptidase 9 and Axin2 genes.	lycorine	44-52	axin 2	Mus musculus	293-298
30565685-5	2019	Collectively, our findings support the notion that targeting the oncogenic beta-catenin by lycorine is a new option to inhibit melanoma cell metastasis, providing a good drug candidate potential for development novel therapeutics against metastatic melanoma.	lycorine	91-99	catenin (cadherin associated protein), beta 1	Mus musculus	75-87
31371981-0	2019	Lycorine exerts antitumor activity against osteosarcoma cells in vitro and in vivo xenograft model through the JAK2/STAT3 pathway.	lycorine	0-8	Janus kinase 2	Homo sapiens	111-115
31371981-0	2019	Lycorine exerts antitumor activity against osteosarcoma cells in vitro and in vivo xenograft model through the JAK2/STAT3 pathway.	lycorine	0-8	signal transducer and activator of transcription 3	Homo sapiens	116-121
31371981-7	2019	Results: The in vitro results demonstrated that lycorine induced apoptosis and cell cycle arrest and suppressed the migration and invasion by suppressing constitutive signal transducers and activators of transcription 3 (STAT3) activation through enhancing the expression of SH2 domain-containing phosphatase 1 (SHP-1) and downregulating the expression of STAT3 target proteins.	lycorine	48-56	signal transducer and activator of transcription 3	Homo sapiens	167-219
31371981-7	2019	Results: The in vitro results demonstrated that lycorine induced apoptosis and cell cycle arrest and suppressed the migration and invasion by suppressing constitutive signal transducers and activators of transcription 3 (STAT3) activation through enhancing the expression of SH2 domain-containing phosphatase 1 (SHP-1) and downregulating the expression of STAT3 target proteins.	lycorine	48-56	signal transducer and activator of transcription 3	Homo sapiens	221-226
31371981-7	2019	Results: The in vitro results demonstrated that lycorine induced apoptosis and cell cycle arrest and suppressed the migration and invasion by suppressing constitutive signal transducers and activators of transcription 3 (STAT3) activation through enhancing the expression of SH2 domain-containing phosphatase 1 (SHP-1) and downregulating the expression of STAT3 target proteins.	lycorine	48-56	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	275-310
31371981-7	2019	Results: The in vitro results demonstrated that lycorine induced apoptosis and cell cycle arrest and suppressed the migration and invasion by suppressing constitutive signal transducers and activators of transcription 3 (STAT3) activation through enhancing the expression of SH2 domain-containing phosphatase 1 (SHP-1) and downregulating the expression of STAT3 target proteins.	lycorine	48-56	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	312-317
31371981-7	2019	Results: The in vitro results demonstrated that lycorine induced apoptosis and cell cycle arrest and suppressed the migration and invasion by suppressing constitutive signal transducers and activators of transcription 3 (STAT3) activation through enhancing the expression of SH2 domain-containing phosphatase 1 (SHP-1) and downregulating the expression of STAT3 target proteins.	lycorine	48-56	signal transducer and activator of transcription 3	Homo sapiens	356-361
31371981-9	2019	Conclusion: These results demonstrated that the anti-OS effects of lycorine were at least partly due to the suppression of the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2)/STAT3 pathway.	lycorine	67-75	Janus kinase 2	Homo sapiens	127-141
31371981-9	2019	Conclusion: These results demonstrated that the anti-OS effects of lycorine were at least partly due to the suppression of the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2)/STAT3 pathway.	lycorine	67-75	signal transducer and activator of transcription 3	Homo sapiens	142-194
31371981-9	2019	Conclusion: These results demonstrated that the anti-OS effects of lycorine were at least partly due to the suppression of the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2)/STAT3 pathway.	lycorine	67-75	Janus kinase 2	Homo sapiens	196-200
31371981-9	2019	Conclusion: These results demonstrated that the anti-OS effects of lycorine were at least partly due to the suppression of the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2)/STAT3 pathway.	lycorine	67-75	signal transducer and activator of transcription 3	Homo sapiens	202-207
31263414-3	2019	We found that lycorine induced mitochondria-dependent apoptosis in HepG2 cells accompanied by mitochondrial permeability transition pore (mPTP) opening, mitochondrial membrane potential (MMP) loss, adenosine triphosphate (ATP) depletion, Ca2+ and cytochrome c (Cyto C) release, as well as caspase activation.	lycorine	14-22	cytochrome c, somatic	Homo sapiens	247-259
31263414-3	2019	We found that lycorine induced mitochondria-dependent apoptosis in HepG2 cells accompanied by mitochondrial permeability transition pore (mPTP) opening, mitochondrial membrane potential (MMP) loss, adenosine triphosphate (ATP) depletion, Ca2+ and cytochrome c (Cyto C) release, as well as caspase activation.	lycorine	14-22	cytochrome c, somatic	Homo sapiens	261-267
31263414-4	2019	Furthermore, we found Rho associated coiled-coil containing protein kinase 1 (ROCK1) cleavage/activation played a critical role in lycorine-induced mitochondrial apoptosis.	lycorine	131-139	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	22-76
31263414-4	2019	Furthermore, we found Rho associated coiled-coil containing protein kinase 1 (ROCK1) cleavage/activation played a critical role in lycorine-induced mitochondrial apoptosis.	lycorine	131-139	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	78-83
31263414-6	2019	Meanwhile, an in vivo study revealed that lycorine inhibited tumor growth and induced apoptosis in a HepG2 xenograft mouse model in association with ROCK1 activation.	lycorine	42-50	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	149-154
31263414-7	2019	Taken together, all these findings suggested that lycorine induced mitochondria-dependent apoptosis through ROCK1 activation in HepG2 cells, and this may be a theoretical basis for lycorine"s anticancer effects.	lycorine	50-58	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	108-113
31263414-7	2019	Taken together, all these findings suggested that lycorine induced mitochondria-dependent apoptosis through ROCK1 activation in HepG2 cells, and this may be a theoretical basis for lycorine"s anticancer effects.	lycorine	181-189	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	108-113
30066939-4	2018	Lycorine inhibited the proliferation of HepG2 cells in a dose-dependent manner by inducing cell cycle arrest at the G2/M phase, via downregulation of cyclin A, cyclin B1 and cyclin dependent kinase 1.	lycorine	0-8	cyclin B1	Homo sapiens	160-169
30403172-0	2018	Lycorine inhibits melanoma A375 cell growth and metastasis through the inactivation of the PI3K/AKT signaling pathway.	lycorine	0-8	AKT serine/threonine kinase 1	Homo sapiens	96-99
30403172-9	2018	Biochemical analyses showed that the expression level of the anti-apoptosis Bcl-2 protein decreased, while the expression of the pro-apoptosis protein Bax and active caspase-3 increased after lycorine treatment.	lycorine	192-200	BCL2 apoptosis regulator	Homo sapiens	76-81
30403172-9	2018	Biochemical analyses showed that the expression level of the anti-apoptosis Bcl-2 protein decreased, while the expression of the pro-apoptosis protein Bax and active caspase-3 increased after lycorine treatment.	lycorine	192-200	BCL2 associated X, apoptosis regulator	Homo sapiens	151-154
30403172-9	2018	Biochemical analyses showed that the expression level of the anti-apoptosis Bcl-2 protein decreased, while the expression of the pro-apoptosis protein Bax and active caspase-3 increased after lycorine treatment.	lycorine	192-200	caspase 3	Homo sapiens	166-175
30403172-10	2018	Finally, using western blot assay, we found that the antitumor effects of lycorine on A375 cells might be through the inactivation of the PI3K/Akt signaling pathway.	lycorine	74-82	AKT serine/threonine kinase 1	Homo sapiens	143-146
30066939-0	2018	Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin-induced actin dynamics in HepG2 hepatoblastoma cells.	lycorine	0-8	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	65-70
30066939-0	2018	Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin-induced actin dynamics in HepG2 hepatoblastoma cells.	lycorine	0-8	cofilin 1	Homo sapiens	71-78
30066939-4	2018	Lycorine inhibited the proliferation of HepG2 cells in a dose-dependent manner by inducing cell cycle arrest at the G2/M phase, via downregulation of cyclin A, cyclin B1 and cyclin dependent kinase 1.	lycorine	0-8	cyclin dependent kinase 1	Homo sapiens	174-199
30066939-4	2018	Lycorine inhibited the proliferation of HepG2 cells in a dose-dependent manner by inducing cell cycle arrest at the G2/M phase, via downregulation of cyclin A, cyclin B1 and cyclin dependent kinase 1.	lycorine	0-8	cyclin A2	Homo sapiens	150-158
30066939-6	2018	Also, treatment with lycorine decreased the expression levels of matrix metalloproteinase (MMP)-9 and MMP-2.	lycorine	21-29	matrix metallopeptidase 9	Homo sapiens	65-97
30066939-6	2018	Also, treatment with lycorine decreased the expression levels of matrix metalloproteinase (MMP)-9 and MMP-2.	lycorine	21-29	matrix metallopeptidase 2	Homo sapiens	102-107
30066939-7	2018	Furthermore, lycorine induced the cleavage/activation of Rho associated coiled-coil containing protein kinase 1 (ROCK1) and the downregulation of cofilin, accompanied by an increase in polymerized filamentous actin and a loss of depolymerized globular actin.	lycorine	13-21	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	57-111
30066939-7	2018	Furthermore, lycorine induced the cleavage/activation of Rho associated coiled-coil containing protein kinase 1 (ROCK1) and the downregulation of cofilin, accompanied by an increase in polymerized filamentous actin and a loss of depolymerized globular actin.	lycorine	13-21	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	113-118
30066939-7	2018	Furthermore, lycorine induced the cleavage/activation of Rho associated coiled-coil containing protein kinase 1 (ROCK1) and the downregulation of cofilin, accompanied by an increase in polymerized filamentous actin and a loss of depolymerized globular actin.	lycorine	13-21	cofilin 1	Homo sapiens	146-153
30066939-8	2018	Furthermore, pre-incubation of cells with Y-27632, a specific ROCK1 inhibitor, markedly attenuated lycorine-induced anti-proliferative and anti-migration effects.	lycorine	99-107	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	62-67
30066939-9	2018	Taken together, the results demonstrated that lycorine inhibited the proliferation and migration of HepG2 cells by suppressing ROCK1/cofilin-induced actin dynamics, which suggests that lycorine has the potential to be developed into a novel drug for hepatoblastoma treatment.	lycorine	46-54	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	127-132
30066939-9	2018	Taken together, the results demonstrated that lycorine inhibited the proliferation and migration of HepG2 cells by suppressing ROCK1/cofilin-induced actin dynamics, which suggests that lycorine has the potential to be developed into a novel drug for hepatoblastoma treatment.	lycorine	46-54	cofilin 1	Homo sapiens	133-140
30066939-9	2018	Taken together, the results demonstrated that lycorine inhibited the proliferation and migration of HepG2 cells by suppressing ROCK1/cofilin-induced actin dynamics, which suggests that lycorine has the potential to be developed into a novel drug for hepatoblastoma treatment.	lycorine	185-193	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	127-132
30066939-9	2018	Taken together, the results demonstrated that lycorine inhibited the proliferation and migration of HepG2 cells by suppressing ROCK1/cofilin-induced actin dynamics, which suggests that lycorine has the potential to be developed into a novel drug for hepatoblastoma treatment.	lycorine	185-193	cofilin 1	Homo sapiens	133-140
30016965-0	2018	Lycorine inhibits glioblastoma multiforme growth through EGFR suppression.	lycorine	0-8	epidermal growth factor receptor	Homo sapiens	57-61
30282321-1	2018	Previously, HLY78, a lycorine derivative, was identified as the first Wnt/beta-catenin signaling agonist through binding to the DAX domain of Axin, a scaffold of Wnt/beta-catenin complex.	lycorine	21-29	catenin beta 1	Homo sapiens	74-86
30282321-1	2018	Previously, HLY78, a lycorine derivative, was identified as the first Wnt/beta-catenin signaling agonist through binding to the DAX domain of Axin, a scaffold of Wnt/beta-catenin complex.	lycorine	21-29	axin 1	Homo sapiens	142-146
30282321-1	2018	Previously, HLY78, a lycorine derivative, was identified as the first Wnt/beta-catenin signaling agonist through binding to the DAX domain of Axin, a scaffold of Wnt/beta-catenin complex.	lycorine	21-29	catenin beta 1	Homo sapiens	166-178
30135654-0	2018	Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3.	lycorine	0-8	signal transducer and activator of transcription 3	Homo sapiens	76-81
30135654-2	2018	In this study, we identify lycorine is an effective inhibitor of STAT3, leading to repression of multiple oncogenic processes in colon carcinoma.	lycorine	27-35	signal transducer and activator of transcription 3	Homo sapiens	65-70
30135654-3	2018	Lycorine selectively inactivates phospho-STAT3 (Tyr-705), and subsequent molecular docking uncovers that lycorine directly binds to the SH2 domain of STAT3.	lycorine	0-8	signal transducer and activator of transcription 3	Homo sapiens	41-46
30135654-3	2018	Lycorine selectively inactivates phospho-STAT3 (Tyr-705), and subsequent molecular docking uncovers that lycorine directly binds to the SH2 domain of STAT3.	lycorine	0-8	signal transducer and activator of transcription 3	Homo sapiens	150-155
30135654-3	2018	Lycorine selectively inactivates phospho-STAT3 (Tyr-705), and subsequent molecular docking uncovers that lycorine directly binds to the SH2 domain of STAT3.	lycorine	105-113	signal transducer and activator of transcription 3	Homo sapiens	41-46
30135654-3	2018	Lycorine selectively inactivates phospho-STAT3 (Tyr-705), and subsequent molecular docking uncovers that lycorine directly binds to the SH2 domain of STAT3.	lycorine	105-113	signal transducer and activator of transcription 3	Homo sapiens	150-155
30135654-5	2018	Lycorine induces the activation of the caspase-dependent mitochondrial apoptotic pathway, as indicated by activation of caspase and increase of the ratio of Bax/Bcl-2 and mitochondrial depolarization.	lycorine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	157-160
30135654-5	2018	Lycorine induces the activation of the caspase-dependent mitochondrial apoptotic pathway, as indicated by activation of caspase and increase of the ratio of Bax/Bcl-2 and mitochondrial depolarization.	lycorine	0-8	BCL2 apoptosis regulator	Homo sapiens	161-166
30135654-6	2018	Overexpressing STAT3 greatly blocks these effects by lycorine in CRC cells.	lycorine	53-61	signal transducer and activator of transcription 3	Homo sapiens	15-20
30135654-7	2018	Finally, lycorine exhibits a potential therapeutic effect in xenograft colorectal tumors by targeting STAT3 without observed toxicity.	lycorine	9-17	signal transducer and activator of transcription 3	Homo sapiens	102-107
30135654-8	2018	Taken together, the present study indicates that lycorine acts as a promising inhibitor of STAT3, which blocks tumorigenesis in colon carcinoma.	lycorine	49-57	signal transducer and activator of transcription 3	Homo sapiens	91-96
30016965-5	2018	METHODS: The molecular docking modeling and in vitro EGFR kinase activity system were employed to identify the potential inhibitory effects of Lycorine on EGFR.	lycorine	143-151	epidermal growth factor receptor	Homo sapiens	53-57
30016965-5	2018	METHODS: The molecular docking modeling and in vitro EGFR kinase activity system were employed to identify the potential inhibitory effects of Lycorine on EGFR.	lycorine	143-151	epidermal growth factor receptor	Homo sapiens	155-159
30016965-6	2018	And the Biacore assay was used to confirm the direct binding status between Lycorine and the intracellular EGFR (696-1022) domain.	lycorine	76-84	epidermal growth factor receptor	Homo sapiens	107-111
30016965-9	2018	RT-PCR and western blotting analysis were carried out to investigate the underlined molecular mechanism that Lycorine exerted on EGFR itself and EGFR signaling pathway.	lycorine	109-117	epidermal growth factor receptor	Homo sapiens	129-133
30016965-9	2018	RT-PCR and western blotting analysis were carried out to investigate the underlined molecular mechanism that Lycorine exerted on EGFR itself and EGFR signaling pathway.	lycorine	109-117	epidermal growth factor receptor	Homo sapiens	145-149
30016965-11	2018	RESULTS: We identified a novel small natural molecule Lycorine binding to the intracellular EGFR (696-1022) domain as an inhibitor of EGFR.	lycorine	54-62	epidermal growth factor receptor	Homo sapiens	92-96
30016965-11	2018	RESULTS: We identified a novel small natural molecule Lycorine binding to the intracellular EGFR (696-1022) domain as an inhibitor of EGFR.	lycorine	54-62	epidermal growth factor receptor	Homo sapiens	134-138
30016965-12	2018	Lycorine decreased GBM cell proliferation, migration and colony formation by inducing cell apoptosis in an EGFR-mediated manner.	lycorine	0-8	epidermal growth factor receptor	Homo sapiens	107-111
30016965-14	2018	Besides, Lycorine impaired the phosphorylation of EGFR, AKT, which were mechanistically associated with expression alteration of a series of cell survival and death regulators and metastasis-related MMP9 protein.	lycorine	9-17	epidermal growth factor receptor	Homo sapiens	50-54
30016965-14	2018	Besides, Lycorine impaired the phosphorylation of EGFR, AKT, which were mechanistically associated with expression alteration of a series of cell survival and death regulators and metastasis-related MMP9 protein.	lycorine	9-17	AKT serine/threonine kinase 1	Homo sapiens	56-59
30016965-14	2018	Besides, Lycorine impaired the phosphorylation of EGFR, AKT, which were mechanistically associated with expression alteration of a series of cell survival and death regulators and metastasis-related MMP9 protein.	lycorine	9-17	matrix metallopeptidase 9	Homo sapiens	199-203
30016965-15	2018	CONCLUSIONS: Our findings identify Lycorine directly interacts with EGFR and inhibits EGFR activation.	lycorine	35-43	epidermal growth factor receptor	Homo sapiens	68-72
28974556-0	2017	Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma.	lycorine	0-8	AKT serine/threonine kinase 1	Homo sapiens	52-55
30016965-15	2018	CONCLUSIONS: Our findings identify Lycorine directly interacts with EGFR and inhibits EGFR activation.	lycorine	35-43	epidermal growth factor receptor	Homo sapiens	86-90
29973327-0	2018	[Lycorine inhibits the proliferation and promotes apoptosis of SGC-7901 gastric cancer cells by downregulating expression of cyclin D1].	lycorine	1-9	sarcoglycan beta	Homo sapiens	63-66
29973327-0	2018	[Lycorine inhibits the proliferation and promotes apoptosis of SGC-7901 gastric cancer cells by downregulating expression of cyclin D1].	lycorine	1-9	cyclin D1	Homo sapiens	125-134
29973327-1	2018	Objective To investigate the effect of lycorine on the proliferation and apoptosis of gastric cancer SGC-7901 cells.	lycorine	39-47	sarcoglycan beta	Homo sapiens	101-104
29973327-2	2018	Methods Effect of lycorine on the proliferation of SGC-7901 cells and 50% inhibitory concentration (IC50) of lycorine were determined by CCK-8 assay.	lycorine	18-26	sarcoglycan beta	Homo sapiens	51-54
29973327-3	2018	SGC-7901 cells were treated with IC50 lycorine, and 48 hours later, cell cycle and apoptosis were detected by flow cytometry, and the level of cyclin D1 mRNA and protein was detected by real-time fluorescence quantitative PCR and Western blot analysis.	lycorine	38-46	sarcoglycan beta	Homo sapiens	0-3
29973327-4	2018	Results Lycorine obviously inhibited the proliferation of SGC-7901 gastric cancer cells in a concentration- or time-dependent manner.	lycorine	8-16	sarcoglycan beta	Homo sapiens	58-61
29973327-6	2018	The cell cycle was arrested in G0/G1 phase, the apoptosis rate of cells increased, and the level of cyclin D1 mRNA and protein decreased significantly 48 hours after the treatment with 13 mumol/L lycorine.	lycorine	196-204	cyclin D1	Homo sapiens	100-109
29973327-7	2018	Conclusion Lycorine can inhibit the proliferation of SGC-7901 gastric cancer cells, induce cell cycle arrest in G0/G1 phase and promote cell apoptosis.	lycorine	11-19	sarcoglycan beta	Homo sapiens	53-56
29127013-0	2018	Lycorine possesses notable anticancer potentials in on-small cell lung carcinoma cells via blocking Wnt/beta-catenin signaling and epithelial-mesenchymal transition (EMT).	lycorine	0-8	catenin beta 1	Homo sapiens	104-116
29127013-6	2018	Moreover, lycorine effectively repressed the Wnt/beta-catenin signaling and reversed epithelial-mesenchymal transition (EMT).	lycorine	10-18	catenin beta 1	Homo sapiens	49-61
28974556-0	2017	Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma.	lycorine	0-8	family with sequence similarity 168 member A	Homo sapiens	46-51
28974556-0	2017	Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma.	lycorine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	56-60
28974556-3	2017	In this research, we have found that lycorine significantly induces the apoptotic and autophagic capacities of hepatocellular carcinoma (HCC) cells in vitro and in vivo Treatment with specific autophagy inhibitor (3-methyladenine/Bafilomycin A1) or knockdown of LC-3B/Atg5 by siRNA drastically enhances the apoptotic cell death effect by facilitating the switch from autophagy to apoptosis.	lycorine	37-45	microtubule associated protein 1 light chain 3 beta	Homo sapiens	262-267
28974556-3	2017	In this research, we have found that lycorine significantly induces the apoptotic and autophagic capacities of hepatocellular carcinoma (HCC) cells in vitro and in vivo Treatment with specific autophagy inhibitor (3-methyladenine/Bafilomycin A1) or knockdown of LC-3B/Atg5 by siRNA drastically enhances the apoptotic cell death effect by facilitating the switch from autophagy to apoptosis.	lycorine	37-45	autophagy related 5	Homo sapiens	268-272
28974556-4	2017	Molecular validation mechanistically demonstrates that lycorine-induced apoptosis and autophagy in HCC cells is associated with decreased protein levels of tongue cancer resistance-associated protein 1 (TCRP1), and we further find that inhibition of TCRP1 decreases phosphorylation level of Akt and represses Akt/mTOR signaling.	lycorine	55-63	family with sequence similarity 168 member A	Homo sapiens	156-201
28974556-4	2017	Molecular validation mechanistically demonstrates that lycorine-induced apoptosis and autophagy in HCC cells is associated with decreased protein levels of tongue cancer resistance-associated protein 1 (TCRP1), and we further find that inhibition of TCRP1 decreases phosphorylation level of Akt and represses Akt/mTOR signaling.	lycorine	55-63	family with sequence similarity 168 member A	Homo sapiens	203-208
28974556-4	2017	Molecular validation mechanistically demonstrates that lycorine-induced apoptosis and autophagy in HCC cells is associated with decreased protein levels of tongue cancer resistance-associated protein 1 (TCRP1), and we further find that inhibition of TCRP1 decreases phosphorylation level of Akt and represses Akt/mTOR signaling.	lycorine	55-63	family with sequence similarity 168 member A	Homo sapiens	250-255
28974556-4	2017	Molecular validation mechanistically demonstrates that lycorine-induced apoptosis and autophagy in HCC cells is associated with decreased protein levels of tongue cancer resistance-associated protein 1 (TCRP1), and we further find that inhibition of TCRP1 decreases phosphorylation level of Akt and represses Akt/mTOR signaling.	lycorine	55-63	AKT serine/threonine kinase 1	Homo sapiens	291-294
28974556-4	2017	Molecular validation mechanistically demonstrates that lycorine-induced apoptosis and autophagy in HCC cells is associated with decreased protein levels of tongue cancer resistance-associated protein 1 (TCRP1), and we further find that inhibition of TCRP1 decreases phosphorylation level of Akt and represses Akt/mTOR signaling.	lycorine	55-63	AKT serine/threonine kinase 1	Homo sapiens	309-312
28974556-4	2017	Molecular validation mechanistically demonstrates that lycorine-induced apoptosis and autophagy in HCC cells is associated with decreased protein levels of tongue cancer resistance-associated protein 1 (TCRP1), and we further find that inhibition of TCRP1 decreases phosphorylation level of Akt and represses Akt/mTOR signaling.	lycorine	55-63	mechanistic target of rapamycin kinase	Homo sapiens	313-317
28974556-6	2017	Our results elucidate a novel molecular mechanism whereby lycorine promotes apoptosis and autophagy through the TCRP1/Akt/mTOR pathway in HCC.	lycorine	58-66	family with sequence similarity 168 member A	Homo sapiens	112-117
28974556-6	2017	Our results elucidate a novel molecular mechanism whereby lycorine promotes apoptosis and autophagy through the TCRP1/Akt/mTOR pathway in HCC.	lycorine	58-66	AKT serine/threonine kinase 1	Homo sapiens	118-121
28974556-6	2017	Our results elucidate a novel molecular mechanism whereby lycorine promotes apoptosis and autophagy through the TCRP1/Akt/mTOR pathway in HCC.	lycorine	58-66	mechanistic target of rapamycin kinase	Homo sapiens	122-126
28910973-0	2017	Lycorine inhibits the growth and metastasis of breast cancer through the blockage of STAT3 signaling pathway.	lycorine	0-8	signal transducer and activator of transcription 3	Homo sapiens	85-90
28910973-2	2017	The purpose of this study is to investigate whether Lycorine, a pyrrolo[de]phenanthridine ring-type alkaloid extracted from Amaryllidaceae genera, could inhibit breast cancer by targeting STAT3 signaling pathway.	lycorine	52-60	signal transducer and activator of transcription 3	Homo sapiens	188-193
28910973-6	2017	Mechanistically, Lycorine significantly inhibited STAT3 phosphorylation and transcriptional activity through upregulating SHP-1 expression.	lycorine	17-25	signal transducer and activator of transcription 3	Homo sapiens	50-55
28910973-6	2017	Mechanistically, Lycorine significantly inhibited STAT3 phosphorylation and transcriptional activity through upregulating SHP-1 expression.	lycorine	17-25	nuclear receptor subfamily 0 group B member 2	Homo sapiens	122-127
28910973-7	2017	Lycorine also downregulated the expressions of STAT3 target genes, including Mcl-1, Bcl-xL, MMP-2, MMP-9, which are involved in apoptosis and invasion of breast cancer.	lycorine	0-8	signal transducer and activator of transcription 3	Homo sapiens	47-52
28910973-7	2017	Lycorine also downregulated the expressions of STAT3 target genes, including Mcl-1, Bcl-xL, MMP-2, MMP-9, which are involved in apoptosis and invasion of breast cancer.	lycorine	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	77-82
28910973-7	2017	Lycorine also downregulated the expressions of STAT3 target genes, including Mcl-1, Bcl-xL, MMP-2, MMP-9, which are involved in apoptosis and invasion of breast cancer.	lycorine	0-8	BCL2 like 1	Homo sapiens	84-90
28910973-7	2017	Lycorine also downregulated the expressions of STAT3 target genes, including Mcl-1, Bcl-xL, MMP-2, MMP-9, which are involved in apoptosis and invasion of breast cancer.	lycorine	0-8	matrix metallopeptidase 2	Homo sapiens	92-97
28910973-7	2017	Lycorine also downregulated the expressions of STAT3 target genes, including Mcl-1, Bcl-xL, MMP-2, MMP-9, which are involved in apoptosis and invasion of breast cancer.	lycorine	0-8	matrix metallopeptidase 9	Homo sapiens	99-104
28450693-0	2017	Lycorine Induces Apoptosis of A549 Cells via AMPK-Mammalian Target of Rapamycin (mTOR)-S6K Signaling Pathway.	lycorine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	45-79
28579903-4	2017	The results showed that the higher the dose, the higher the rate of apoptosis and that the rate of apoptosis was dependent on the dose; the relative protein activity of Fas, FasL, Caspase-8 and bid gradually rose with the increase of lycorine dosage and the activities revealed certain dose-independence.	lycorine	234-242	Fas ligand	Homo sapiens	174-178
28579903-4	2017	The results showed that the higher the dose, the higher the rate of apoptosis and that the rate of apoptosis was dependent on the dose; the relative protein activity of Fas, FasL, Caspase-8 and bid gradually rose with the increase of lycorine dosage and the activities revealed certain dose-independence.	lycorine	234-242	caspase 8	Homo sapiens	180-189
28579903-4	2017	The results showed that the higher the dose, the higher the rate of apoptosis and that the rate of apoptosis was dependent on the dose; the relative protein activity of Fas, FasL, Caspase-8 and bid gradually rose with the increase of lycorine dosage and the activities revealed certain dose-independence.	lycorine	234-242	BH3 interacting domain death agonist	Homo sapiens	194-197
28450693-0	2017	Lycorine Induces Apoptosis of A549 Cells via AMPK-Mammalian Target of Rapamycin (mTOR)-S6K Signaling Pathway.	lycorine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	81-85
28450693-1	2017	BACKGROUND This study was designed to investigate the effect of lycorine (LY) on the AMPK-mTOR-S6K signaling pathway and to clarify its role in autophagy and apoptosis.	lycorine	64-72	mechanistic target of rapamycin kinase	Homo sapiens	90-94
28450693-1	2017	BACKGROUND This study was designed to investigate the effect of lycorine (LY) on the AMPK-mTOR-S6K signaling pathway and to clarify its role in autophagy and apoptosis.	lycorine	74-76	mechanistic target of rapamycin kinase	Homo sapiens	90-94
28450693-11	2017	Lower levels (4~8 muM) of LY-induced autophagy contributed to LY-induced apoptosis.	lycorine	26-28	latexin	Homo sapiens	18-21
28450693-11	2017	Lower levels (4~8 muM) of LY-induced autophagy contributed to LY-induced apoptosis.	lycorine	62-64	latexin	Homo sapiens	18-21
27847203-0	2016	Lycorine induces cell death in MM by suppressing Janus Kinase/signal transducer and activator of transcription via inducing the expression of SOCS1.	lycorine	0-8	suppressor of cytokine signaling 1	Homo sapiens	142-147
28251459-0	2017	Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway.	lycorine	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-93
28251459-0	2017	Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway.	lycorine	0-8	protein tyrosine kinase 2	Homo sapiens	94-97
28251459-7	2017	Furthermore, on mechanism, lycorine inhibited tumor cell migration and invasion via blocking the Src/FAK (focal adhesion kinase)-involved pathway.	lycorine	27-35	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	97-100
28251459-7	2017	Furthermore, on mechanism, lycorine inhibited tumor cell migration and invasion via blocking the Src/FAK (focal adhesion kinase)-involved pathway.	lycorine	27-35	protein tyrosine kinase 2	Homo sapiens	101-104
28042037-0	2017	Lycorine induces apoptosis of bladder cancer T24 cells by inhibiting phospho-Akt and activating the intrinsic apoptotic cascade.	lycorine	0-8	AKT serine/threonine kinase 1	Homo sapiens	77-80
28042037-3	2017	In this study, we demonstrated that lycorine induced apoptosis in human bladder cancer T24 cells, an effect that is mediated via inhibition of phospho-Akt expression and the consequent activation of caspase-3 and Bax in vitro.	lycorine	36-44	AKT serine/threonine kinase 1	Homo sapiens	151-154
28042037-3	2017	In this study, we demonstrated that lycorine induced apoptosis in human bladder cancer T24 cells, an effect that is mediated via inhibition of phospho-Akt expression and the consequent activation of caspase-3 and Bax in vitro.	lycorine	36-44	caspase 3	Homo sapiens	199-208
28042037-3	2017	In this study, we demonstrated that lycorine induced apoptosis in human bladder cancer T24 cells, an effect that is mediated via inhibition of phospho-Akt expression and the consequent activation of caspase-3 and Bax in vitro.	lycorine	36-44	BCL2 associated X, apoptosis regulator	Homo sapiens	213-216
28042037-6	2017	Collectively, our findings suggest that lycorine suppressed the Akt pathway and activated the intrinsic apoptotic cascade, leading to the apoptosis of bladder cancer cells.	lycorine	40-48	AKT serine/threonine kinase 1	Homo sapiens	64-67
27847203-6	2016	Further mechanism analysis demonstrated that lycorine inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells and patient MM cells.Importantly, we found that knockdown of HDAC8 resulted in increased expression of SOCS1.	lycorine	45-53	Janus kinase 2	Homo sapiens	64-68
27847203-6	2016	Further mechanism analysis demonstrated that lycorine inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells and patient MM cells.Importantly, we found that knockdown of HDAC8 resulted in increased expression of SOCS1.	lycorine	45-53	suppressor of cytokine signaling 1	Homo sapiens	108-113
27847203-6	2016	Further mechanism analysis demonstrated that lycorine inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells and patient MM cells.Importantly, we found that knockdown of HDAC8 resulted in increased expression of SOCS1.	lycorine	45-53	histone deacetylase 8	Homo sapiens	187-192
27847203-6	2016	Further mechanism analysis demonstrated that lycorine inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells and patient MM cells.Importantly, we found that knockdown of HDAC8 resulted in increased expression of SOCS1.	lycorine	45-53	suppressor of cytokine signaling 1	Homo sapiens	229-234
27847203-7	2016	Collectively, our findings suggested lycorine acted as a potent novel histone deacetylase inhibitor and inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells.	lycorine	37-45	Janus kinase 2	Homo sapiens	114-118
27847203-7	2016	Collectively, our findings suggested lycorine acted as a potent novel histone deacetylase inhibitor and inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells.	lycorine	37-45	suppressor of cytokine signaling 1	Homo sapiens	158-163
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	cyclin dependent kinase 4	Homo sapiens	41-45
27509914-4	2016	The effects of lycorine on IL-1beta-induced upregulation of MMPs and activation of mitogen-activated protein kinase pathways were detected by western blot analysis and reverse transcription-quantitative polymerase chain reaction.	lycorine	15-23	interleukin 1 beta	Mus musculus	27-35
27509914-4	2016	The effects of lycorine on IL-1beta-induced upregulation of MMPs and activation of mitogen-activated protein kinase pathways were detected by western blot analysis and reverse transcription-quantitative polymerase chain reaction.	lycorine	15-23	matrix metallopeptidase 13	Mus musculus	60-64
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	97-105	interleukin 1 beta	Mus musculus	122-139
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	97-105	interleukin 1 beta	Mus musculus	141-149
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	97-105	matrix metallopeptidase 3	Mus musculus	172-177
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	97-105	matrix metallopeptidase 13	Mus musculus	182-188
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	107-109	interleukin 1 beta	Mus musculus	122-139
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	107-109	interleukin 1 beta	Mus musculus	141-149
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	107-109	matrix metallopeptidase 3	Mus musculus	172-177
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	107-109	matrix metallopeptidase 13	Mus musculus	182-188
27924158-0	2016	Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma.	lycorine	0-8	high mobility group box 1	Homo sapiens	23-28
27924158-4	2016	We identified High mobility group box 1 (HMGB1), an important regulator of autophagy, as the most aberrantly expressed protein after lycorine treatment and as a critical mediator of lycorine activity.	lycorine	133-141	high mobility group box 1	Homo sapiens	14-39
27924158-4	2016	We identified High mobility group box 1 (HMGB1), an important regulator of autophagy, as the most aberrantly expressed protein after lycorine treatment and as a critical mediator of lycorine activity.	lycorine	133-141	high mobility group box 1	Homo sapiens	41-46
27924158-4	2016	We identified High mobility group box 1 (HMGB1), an important regulator of autophagy, as the most aberrantly expressed protein after lycorine treatment and as a critical mediator of lycorine activity.	lycorine	182-190	high mobility group box 1	Homo sapiens	14-39
27924158-4	2016	We identified High mobility group box 1 (HMGB1), an important regulator of autophagy, as the most aberrantly expressed protein after lycorine treatment and as a critical mediator of lycorine activity.	lycorine	182-190	high mobility group box 1	Homo sapiens	41-46
27924158-7	2016	Mechanistically, proteasomal degradation of HMGB1 by lycorine inhibits the activation of MEK-ERK thereby decreases phosphorylation of Bcl-2 resulting in constitutive association of Bcl-2 with Beclin-1.	lycorine	53-61	high mobility group box 1	Homo sapiens	44-49
27924158-7	2016	Mechanistically, proteasomal degradation of HMGB1 by lycorine inhibits the activation of MEK-ERK thereby decreases phosphorylation of Bcl-2 resulting in constitutive association of Bcl-2 with Beclin-1.	lycorine	53-61	mitogen-activated protein kinase kinase 7	Homo sapiens	89-92
27924158-7	2016	Mechanistically, proteasomal degradation of HMGB1 by lycorine inhibits the activation of MEK-ERK thereby decreases phosphorylation of Bcl-2 resulting in constitutive association of Bcl-2 with Beclin-1.	lycorine	53-61	mitogen-activated protein kinase 1	Homo sapiens	93-96
27924158-7	2016	Mechanistically, proteasomal degradation of HMGB1 by lycorine inhibits the activation of MEK-ERK thereby decreases phosphorylation of Bcl-2 resulting in constitutive association of Bcl-2 with Beclin-1.	lycorine	53-61	BCL2 apoptosis regulator	Homo sapiens	134-139
27924158-7	2016	Mechanistically, proteasomal degradation of HMGB1 by lycorine inhibits the activation of MEK-ERK thereby decreases phosphorylation of Bcl-2 resulting in constitutive association of Bcl-2 with Beclin-1.	lycorine	53-61	BCL2 apoptosis regulator	Homo sapiens	181-186
27924158-7	2016	Mechanistically, proteasomal degradation of HMGB1 by lycorine inhibits the activation of MEK-ERK thereby decreases phosphorylation of Bcl-2 resulting in constitutive association of Bcl-2 with Beclin-1.	lycorine	53-61	beclin 1	Homo sapiens	192-200
27924158-8	2016	In addition, we observed higher HMGB1 expression in bortezomib resistant cells and the combination of bortezomib plus lycorine was highly efficient in vitro and in vivo myeloma models as well as in re-sensitizing resistant cells to bortezomib.	lycorine	118-126	high mobility group box 1	Homo sapiens	32-37
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	47-50
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	caspase 3	Homo sapiens	52-61
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	BCL2 apoptosis regulator	Homo sapiens	107-112
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	cyclin D1	Homo sapiens	117-126
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	cyclin dependent kinase 4	Homo sapiens	150-154
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	159-162
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	cyclin D1	Homo sapiens	182-191
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	BCL2 apoptosis regulator	Homo sapiens	193-198
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	caspase 3	Homo sapiens	245-254
26714198-0	2016	Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/beta-Catenin Signaling Pathway Agonists.	lycorine	50-58	catenin beta 1	Homo sapiens	101-113
26714198-2	2016	A lycorine derivative, HLY78, was previously identified as a new Wnt/beta-catenin signaling pathway agonist that targets the DAX domain of axin.	lycorine	2-10	catenin beta 1	Homo sapiens	69-81
26714198-2	2016	A lycorine derivative, HLY78, was previously identified as a new Wnt/beta-catenin signaling pathway agonist that targets the DAX domain of axin.	lycorine	2-10	axin 1	Homo sapiens	139-143
26714198-3	2016	Herein, the structural optimization of HLY78 and analyses of the structure-activity relationships of lycorine-derived phenanthridine derivatives as agonists of the Wnt/beta-catenin signaling pathway are presented.	lycorine	101-109	catenin beta 1	Homo sapiens	168-180
26238331-0	2015	Lycorine suppresses RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced osteoporosis and titanium particle-induced osteolysis in vivo.	lycorine	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	20-25
26443922-3	2015	Further research on the antivirus mechanism indicated that lycorine does not affect the enzymes that are indispensable to HCV replication but suppresses the expression of Hsc70 in the host cell to limit HCV replication.	lycorine	59-67	heat shock protein family A (Hsp70) member 8	Homo sapiens	171-176
25529145-9	2015	The results suggest that the neuroprotective effects might be associated with lycorine and crinine-type alkaloids, whereas the acetylcholinesterase enzyme inhibitory activity could be related to galanthamine and lycorine-type alkaloids, although not based on synergistic processes.	lycorine	212-220	acetylcholinesterase	Rattus norvegicus	127-147
25487618-0	2015	Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77.	lycorine	0-8	low density lipoprotein receptor adaptor protein 1	Homo sapiens	71-74
25487618-3	2015	In this study, the results demonstrated that lycorine is effective against multiple myeloma cell line ARH-77 via inducing programmed necrosis.	lycorine	45-53	low density lipoprotein receptor adaptor protein 1	Homo sapiens	102-105
25487618-4	2015	The mechanisms of lycorine on the multiple myeloma cell line ARH-77 are associated with G1 phase cell cycle arrest, mitochondrial dysfunction, reactive oxygen species (ROS) generation, ATP depletion, and DNA damage.	lycorine	18-26	low density lipoprotein receptor adaptor protein 1	Homo sapiens	61-64
26790307-8	2015	The results showed that lycorine significantly inhibited the proliferation of A549 cells (P < 0.05), induced the apoptosis on A549 cells (P < 0.05), increased the activities of Bax and p53, reduced Bcl-2 activity and mitochondrial membrane potential, and notably changed the gene expressions of Bcl-2, Bax, p53 and Survivin (P < 0.05).	lycorine	24-32	BCL2 associated X, apoptosis regulator	Homo sapiens	183-186
26790307-8	2015	The results showed that lycorine significantly inhibited the proliferation of A549 cells (P < 0.05), induced the apoptosis on A549 cells (P < 0.05), increased the activities of Bax and p53, reduced Bcl-2 activity and mitochondrial membrane potential, and notably changed the gene expressions of Bcl-2, Bax, p53 and Survivin (P < 0.05).	lycorine	24-32	tumor protein p53	Homo sapiens	191-194
26790307-8	2015	The results showed that lycorine significantly inhibited the proliferation of A549 cells (P < 0.05), induced the apoptosis on A549 cells (P < 0.05), increased the activities of Bax and p53, reduced Bcl-2 activity and mitochondrial membrane potential, and notably changed the gene expressions of Bcl-2, Bax, p53 and Survivin (P < 0.05).	lycorine	24-32	BCL2 apoptosis regulator	Homo sapiens	204-209
26790307-8	2015	The results showed that lycorine significantly inhibited the proliferation of A549 cells (P < 0.05), induced the apoptosis on A549 cells (P < 0.05), increased the activities of Bax and p53, reduced Bcl-2 activity and mitochondrial membrane potential, and notably changed the gene expressions of Bcl-2, Bax, p53 and Survivin (P < 0.05).	lycorine	24-32	BCL2 apoptosis regulator	Homo sapiens	301-306
26790307-8	2015	The results showed that lycorine significantly inhibited the proliferation of A549 cells (P < 0.05), induced the apoptosis on A549 cells (P < 0.05), increased the activities of Bax and p53, reduced Bcl-2 activity and mitochondrial membrane potential, and notably changed the gene expressions of Bcl-2, Bax, p53 and Survivin (P < 0.05).	lycorine	24-32	BCL2 associated X, apoptosis regulator	Homo sapiens	308-311
26790307-8	2015	The results showed that lycorine significantly inhibited the proliferation of A549 cells (P < 0.05), induced the apoptosis on A549 cells (P < 0.05), increased the activities of Bax and p53, reduced Bcl-2 activity and mitochondrial membrane potential, and notably changed the gene expressions of Bcl-2, Bax, p53 and Survivin (P < 0.05).	lycorine	24-32	tumor protein p53	Homo sapiens	313-316
25594182-9	2015	A chemical genetic screen found that the compound lycorine promotes HSPC-niche interactions during development and ultimately expands the stem cell pool into adulthood.	lycorine	50-58	proteasome 20S subunit alpha 7	Homo sapiens	68-72
23376478-4	2013	Our data showed that LH effectively inhibited mitotic proliferation of Hey1B cells (half maximal inhibitory concentration=1.2muM) with very low toxicity, resulting in cell cycle arrest at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression.	lycorine	21-23	H3 histone pseudogene 16	Homo sapiens	264-267
23136954-6	2013	RESULTS: Among the alkaloids, lycorine (AA1), hippeastrine (AA2), hemanthamine (AA3) and 11-hydroxy vittatine (AA4) exhibited antiviral activities, with EC90 values of 0 52, 82 07, 4 15, and 13 45 mum, respectively.	lycorine	30-38	AA1	Homo sapiens	40-43
23136954-6	2013	RESULTS: Among the alkaloids, lycorine (AA1), hippeastrine (AA2), hemanthamine (AA3) and 11-hydroxy vittatine (AA4) exhibited antiviral activities, with EC90 values of 0 52, 82 07, 4 15, and 13 45 mum, respectively.	lycorine	30-38	AA2	Homo sapiens	60-63
23376478-4	2013	Our data showed that LH effectively inhibited mitotic proliferation of Hey1B cells (half maximal inhibitory concentration=1.2muM) with very low toxicity, resulting in cell cycle arrest at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression.	lycorine	21-23	cyclin D3	Homo sapiens	298-307
23176676-14	2012	After lycorine treatment, cyclin D1 and cyclin-dependent kinase 4 expressions were inhibited and retinoblastoma protein phosphorylation was reduced.	lycorine	6-14	cyclin dependent kinase 4	Homo sapiens	40-65
23176676-14	2012	After lycorine treatment, cyclin D1 and cyclin-dependent kinase 4 expressions were inhibited and retinoblastoma protein phosphorylation was reduced.	lycorine	6-14	cyclin D1	Homo sapiens	26-35
23176676-15	2012	Lycorine treatment also significantly upregulated the expression of p53 and its target gene product, p21.	lycorine	0-8	tumor protein p53	Homo sapiens	68-71
23176676-15	2012	Lycorine treatment also significantly upregulated the expression of p53 and its target gene product, p21.	lycorine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-104
22958411-5	2012	The structure-activity relationships indicated that (i) the 1-O-(methylthio)methyl substituent in lycorine was better than the 1-O-acetyl group for the inhibition of cholinesterase; (ii) the acylated or etherified derivatives of lycorine and lycorin-2-one were more potent against hBChE than hAChE; and (iii) the oxidation of lycorine at C-2 decreases the activity.	lycorine	98-106	butyrylcholinesterase	Homo sapiens	166-180
23058055-2	2012	The aim of the present study was to evaluate whether nine potentially CNS-active Amaryllidaceae alkaloids of the crinine, lycorine and galanthamine types interact with P-gp.	lycorine	122-130	PGP	Canis lupus familiaris	168-172
22958411-0	2012	Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase.	lycorine	39-47	butyrylcholinesterase	Homo sapiens	113-134
22958411-5	2012	The structure-activity relationships indicated that (i) the 1-O-(methylthio)methyl substituent in lycorine was better than the 1-O-acetyl group for the inhibition of cholinesterase; (ii) the acylated or etherified derivatives of lycorine and lycorin-2-one were more potent against hBChE than hAChE; and (iii) the oxidation of lycorine at C-2 decreases the activity.	lycorine	98-106	butyrylcholinesterase	Homo sapiens	281-286
22958411-3	2012	FINDINGS: A series of lycorine derivatives (1-10) were synthesized and evaluated for anti-cholinesterase activity.	lycorine	22-30	butyrylcholinesterase	Homo sapiens	90-104
22958411-5	2012	The structure-activity relationships indicated that (i) the 1-O-(methylthio)methyl substituent in lycorine was better than the 1-O-acetyl group for the inhibition of cholinesterase; (ii) the acylated or etherified derivatives of lycorine and lycorin-2-one were more potent against hBChE than hAChE; and (iii) the oxidation of lycorine at C-2 decreases the activity.	lycorine	98-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	292-297
22958411-5	2012	The structure-activity relationships indicated that (i) the 1-O-(methylthio)methyl substituent in lycorine was better than the 1-O-acetyl group for the inhibition of cholinesterase; (ii) the acylated or etherified derivatives of lycorine and lycorin-2-one were more potent against hBChE than hAChE; and (iii) the oxidation of lycorine at C-2 decreases the activity.	lycorine	98-106	complement C2	Homo sapiens	338-341
22958411-5	2012	The structure-activity relationships indicated that (i) the 1-O-(methylthio)methyl substituent in lycorine was better than the 1-O-acetyl group for the inhibition of cholinesterase; (ii) the acylated or etherified derivatives of lycorine and lycorin-2-one were more potent against hBChE than hAChE; and (iii) the oxidation of lycorine at C-2 decreases the activity.	lycorine	229-237	butyrylcholinesterase	Homo sapiens	166-180
22958411-5	2012	The structure-activity relationships indicated that (i) the 1-O-(methylthio)methyl substituent in lycorine was better than the 1-O-acetyl group for the inhibition of cholinesterase; (ii) the acylated or etherified derivatives of lycorine and lycorin-2-one were more potent against hBChE than hAChE; and (iii) the oxidation of lycorine at C-2 decreases the activity.	lycorine	229-237	butyrylcholinesterase	Homo sapiens	166-180
22958411-6	2012	CONCLUSION: Acylated or etherified derivatives of lycorine are potential dual inhibitors of hBChE and hAChE.	lycorine	50-58	butyrylcholinesterase	Homo sapiens	92-97
22958411-6	2012	CONCLUSION: Acylated or etherified derivatives of lycorine are potential dual inhibitors of hBChE and hAChE.	lycorine	50-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	102-107
22958411-7	2012	Hence, further study on the modification of lycorine for ChE inhibition is necessary.	lycorine	44-52	butyrylcholinesterase	Homo sapiens	57-60
22508048-7	2012	Real-time RT-PCR showed that lycorine enhanced RORalpha and Bmal1 transcription, and exogenous expression and knockdown of Bmal1 also caused long and short periods, respectively, thus confirming the phenotype indicated by lycorine.	lycorine	29-37	RAR related orphan receptor A	Homo sapiens	47-55
22908593-0	2012	Acetylcholinesterase inhibition within the lycorine series of Amaryllidaceae alkaloids.	lycorine	43-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
22908593-4	2012	The lycorine series of compounds within the family have recently emerged as novel inhibitors of AChE, in some instances with higher levels of activity compared with the commercial drug galanthamine, making them attractive targets for natural product and synthetically-driven structure-activity relationship studies.	lycorine	4-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	96-100
22508048-7	2012	Real-time RT-PCR showed that lycorine enhanced RORalpha and Bmal1 transcription, and exogenous expression and knockdown of Bmal1 also caused long and short periods, respectively, thus confirming the phenotype indicated by lycorine.	lycorine	29-37	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	60-65
22508048-7	2012	Real-time RT-PCR showed that lycorine enhanced RORalpha and Bmal1 transcription, and exogenous expression and knockdown of Bmal1 also caused long and short periods, respectively, thus confirming the phenotype indicated by lycorine.	lycorine	222-230	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	123-128
22508048-8	2012	These data indicate that lycorine and lycoricidinol modulate Bmal1 transcription and the circadian period, and also suggest that Lycoris alkaloids are novel contributors to the control of period length in mammalian cells.	lycorine	25-33	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	61-66
21968064-11	2012	Hepatoprotective activity of lycorine on carbon tetrachloride (CCl(4)) induced acute liver toxicity following biochemical parameters were also evaluated.	lycorine	29-37	C-C motif chemokine ligand 4	Rattus norvegicus	63-69
22155741-0	2012	Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge.	lycorine	0-8	nitric oxide synthase 2, inducible	Mus musculus	45-49
22155741-0	2012	Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge.	lycorine	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	54-59
22155741-2	2012	Here we show that lycorine dose-dependently inhibited the LPS-induced up-regulation of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells.	lycorine	18-26	nitric oxide synthase 2, inducible	Mus musculus	110-114
22155741-2	2012	Here we show that lycorine dose-dependently inhibited the LPS-induced up-regulation of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells.	lycorine	18-26	prostaglandin-endoperoxide synthase 2	Mus musculus	120-136
22155741-2	2012	Here we show that lycorine dose-dependently inhibited the LPS-induced up-regulation of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells.	lycorine	18-26	prostaglandin-endoperoxide synthase 2	Mus musculus	138-143
22155741-4	2012	RT-PCR experiments showed that lycorine suppressed LPS-induced iNOS but not COX-2 gene expression.	lycorine	31-39	nitric oxide synthase 2, inducible	Mus musculus	63-67
21372424-3	2011	A harmala alkaloid, harmine, an opium alkaloid, papaverine, and Lycoris alkaloids, lycorine and lycoricidinol, showed TNF-alpha suppressive activities stronger than or comparable to that of a reference polyphenol, butein, in RAW264 cells (IC(50)=4, 10, 2.1, 0.02, and 8 microM, respectively).	lycorine	83-91	tumor necrosis factor	Mus musculus	118-127
21626407-10	2011	Thus, it is the first in vivo report evidencing that predominantly neurokinin-1 (NK1) and to a lesser extent 5-hydroxytryptamine 3 (5-HT3) receptors are involved in lycorine-induced emesis facilitating a target-oriented therapy.	lycorine	165-173	tachykinin precursor 1	Homo sapiens	67-79
21626407-10	2011	Thus, it is the first in vivo report evidencing that predominantly neurokinin-1 (NK1) and to a lesser extent 5-hydroxytryptamine 3 (5-HT3) receptors are involved in lycorine-induced emesis facilitating a target-oriented therapy.	lycorine	165-173	tachykinin precursor 1	Homo sapiens	81-84
19591492-1	2009	The pentacyclic framework associated with the alkaloid (-)-lycorine (1) can be assembled in as few as six steps from the enantiomerically pure cis-1,2-dihydrocatechol 3 which is itself readily available on a large scale through the whole-cell biotransformation of bromobenzene.	lycorine	55-67	suppressor of cytokine signaling 1	Homo sapiens	143-148
20839617-0	2010	Cytochrome P450 3A4 inhibitory activity studies within the lycorine series of alkaloids.	lycorine	59-67	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-19
20839617-1	2010	A mini-panel of semi-synthetic analogs of the Amaryllidaceae alkaloid lycorine was screened for cytochrome P450 3A4 (CYP3A4) inhibitory activity, the most potent of which exhibited inhibition as low as 0.21 microM.	lycorine	70-78	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	96-115
20839617-1	2010	A mini-panel of semi-synthetic analogs of the Amaryllidaceae alkaloid lycorine was screened for cytochrome P450 3A4 (CYP3A4) inhibitory activity, the most potent of which exhibited inhibition as low as 0.21 microM.	lycorine	70-78	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	117-123
20634492-0	2010	Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrate- and medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance.	lycorine	0-8	CD40 molecule	Homo sapiens	20-24
20634492-4	2010	Here, we assessed the ability of dasatinib and lycorine to restore bezafibrate- and medroxyprogesterone acetate- induced apoptosis in cells exposed to CD40 ligand.	lycorine	47-55	CD40 ligand	Homo sapiens	151-162
20634492-11	2010	In contrast, lycorine restored the bezafibrate- and medroxyprogesterone acetate-induced apoptosis associated with mitochondrial superoxide even during continuous exposure to CD40 ligand.	lycorine	13-21	CD40 molecule	Homo sapiens	174-178
20655219-0	2010	Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids.	lycorine	69-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-50
20655219-1	2010	The synthesis of differentially functionalized analogs of the Amaryllidaceae alkaloid lycorine, accessed via a concise chemoselective silylation strategy, is described uncovering two of the most potent inhibitors of acetylcholinesterase (AChE) identified to date in this series.	lycorine	86-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	216-236
20655219-1	2010	The synthesis of differentially functionalized analogs of the Amaryllidaceae alkaloid lycorine, accessed via a concise chemoselective silylation strategy, is described uncovering two of the most potent inhibitors of acetylcholinesterase (AChE) identified to date in this series.	lycorine	86-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	238-242
20682078-0	2010	Up-regulation of p21 and TNF-alpha is mediated in lycorine-induced death of HL-60 cells.	lycorine	50-58	H3 histone pseudogene 16	Homo sapiens	17-20
20682078-0	2010	Up-regulation of p21 and TNF-alpha is mediated in lycorine-induced death of HL-60 cells.	lycorine	50-58	tumor necrosis factor	Homo sapiens	25-34
20682078-8	2010	RESULTS: When HL-60 cells were treated with different concentration of lycorine, the expression of p21 and TNF-alpha was up-regulated in a concentration-dependent manner as shown by real-time quantitative reverse transcriptase-polymerase chain reaction and Western blotting.	lycorine	71-79	H3 histone pseudogene 16	Homo sapiens	99-102
20682078-8	2010	RESULTS: When HL-60 cells were treated with different concentration of lycorine, the expression of p21 and TNF-alpha was up-regulated in a concentration-dependent manner as shown by real-time quantitative reverse transcriptase-polymerase chain reaction and Western blotting.	lycorine	71-79	tumor necrosis factor	Homo sapiens	107-116
20682078-9	2010	Lycorine also down-regulated p21-related gene expression, including Cdc2, Cyclin B, Cdk2 and Cyclin E, promoted Bid truncation, decreased IkappaB phosphorylation and blocked NF-kappaB nuclear import.	lycorine	0-8	H3 histone pseudogene 16	Homo sapiens	29-32
20682078-9	2010	Lycorine also down-regulated p21-related gene expression, including Cdc2, Cyclin B, Cdk2 and Cyclin E, promoted Bid truncation, decreased IkappaB phosphorylation and blocked NF-kappaB nuclear import.	lycorine	0-8	cyclin dependent kinase 1	Homo sapiens	68-72
20682078-9	2010	Lycorine also down-regulated p21-related gene expression, including Cdc2, Cyclin B, Cdk2 and Cyclin E, promoted Bid truncation, decreased IkappaB phosphorylation and blocked NF-kappaB nuclear import.	lycorine	0-8	cyclin dependent kinase 2	Homo sapiens	84-88
20682078-9	2010	Lycorine also down-regulated p21-related gene expression, including Cdc2, Cyclin B, Cdk2 and Cyclin E, promoted Bid truncation, decreased IkappaB phosphorylation and blocked NF-kappaB nuclear import.	lycorine	0-8	BH3 interacting domain death agonist	Homo sapiens	112-115
20682078-9	2010	Lycorine also down-regulated p21-related gene expression, including Cdc2, Cyclin B, Cdk2 and Cyclin E, promoted Bid truncation, decreased IkappaB phosphorylation and blocked NF-kappaB nuclear import.	lycorine	0-8	nuclear factor kappa B subunit 1	Homo sapiens	174-183
20682078-11	2010	CONCLUSIONS: The TNF-alpha signal transduction pathway and p21-mediated cell-cycle inhibition were involved in the apoptosis of HL-60 cells induced by lycorine.	lycorine	151-159	tumor necrosis factor	Homo sapiens	17-26
20682078-11	2010	CONCLUSIONS: The TNF-alpha signal transduction pathway and p21-mediated cell-cycle inhibition were involved in the apoptosis of HL-60 cells induced by lycorine.	lycorine	151-159	H3 histone pseudogene 16	Homo sapiens	59-62
34594422-10	2021	After lycorine treatment, the expression levels of GPX4 in RCC cells decreased, whereas those of ACSL4 increased.	lycorine	6-14	glutathione peroxidase 4	Homo sapiens	51-55
18829157-0	2009	Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells.	lycorine	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	50-55
18829157-3	2009	Lycorine induced apoptosis in human leukemia cells via intrinsic mitochondria pathway and caused a rapid-turnover of protein level of Mcl-1 which occurred before caspases activation.	lycorine	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	134-139
17203177-7	2007	The results also showed that lycorine was able to block the cell cycle at the G0/G1 phase through the downregulation of both cyclin D1 and CDK4.	lycorine	29-37	cyclin D1	Homo sapiens	125-134
17203177-7	2007	The results also showed that lycorine was able to block the cell cycle at the G0/G1 phase through the downregulation of both cyclin D1 and CDK4.	lycorine	29-37	cyclin dependent kinase 4	Homo sapiens	139-143
15589827-5	2004	The increase of caspase-8, -9, -3 activities demonstrated that caspase was a key mediator of apoptotic pathways induced by lycorine.	lycorine	123-131	caspase 8	Homo sapiens	16-25
11218731-0	2001	[Inhibition effect of Amaryllidaceae alkaloids, lycorine and lycoricidinol on macrophage TNF-alpha production].	lycorine	48-56	tumor necrosis factor	Rattus norvegicus	89-98
11218731-4	2001	As a result of this study, lycorine and lycoricidinol inhibited TNF-alpha production of murine macrophages stimulated with lipopolysaccharide (ID50 were 0.2 microgram/ml and 0.002 microgram/ml, respectively).	lycorine	27-35	tumor necrosis factor	Mus musculus	64-73
11218731-7	2001	Although the inhibition of TNF-alpha production by lycoricidinol was mainly due to the inhibition of protein biosynthesis, lycorine showed inhibition against TNF-alpha production at lower concentrations than the case that they inhibited 35S-Cysteine/35S-Methionine incorporation into macrophages.	lycorine	123-131	tumor necrosis factor	Rattus norvegicus	158-167
34863821-14	2022	Taken together, lycorine was advised to promote Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation-induced LC3-II transformation in diabetic peripheral neuropathy.	lycorine	16-24	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	75-79
34863821-14	2022	Taken together, lycorine was advised to promote Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation-induced LC3-II transformation in diabetic peripheral neuropathy.	lycorine	16-24	matrix metallopeptidase 9	Mus musculus	103-107
34863821-14	2022	Taken together, lycorine was advised to promote Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation-induced LC3-II transformation in diabetic peripheral neuropathy.	lycorine	16-24	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	131-134
17336028-0	2007	Treatment of lycorine on SCID mice model with human APL cells.	lycorine	13-21	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	25-29
17336028-11	2007	When SCID mice inoculated with HL-60 cells were then treated with lycorine, no severe adverse effects were observed.	lycorine	66-74	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	5-9
33761445-11	2021	AO/EB staining and Annexin V-FITC/PI staining showed that lycorine induced apoptosis in a concentration-dependent manner.	lycorine	58-66	annexin A5	Homo sapiens	19-28
33761445-15	2021	Furthermore, based on transcriptomic analysis, we found that the tumor necrosis factor (TNF) pathway and endoplasmic reticulum stress were responsible for lycorine-induced apoptosis.	lycorine	155-163	tumor necrosis factor	Homo sapiens	65-86
33761445-15	2021	Furthermore, based on transcriptomic analysis, we found that the tumor necrosis factor (TNF) pathway and endoplasmic reticulum stress were responsible for lycorine-induced apoptosis.	lycorine	155-163	tumor necrosis factor	Homo sapiens	88-91
34863821-0	2022	Lycorine improves peripheral nerve function by promoting Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral neuropathy.	lycorine	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	84-88
34863821-0	2022	Lycorine improves peripheral nerve function by promoting Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral neuropathy.	lycorine	0-8	matrix metallopeptidase 9	Rattus norvegicus	112-116
34863821-4	2022	Again, in vitro high glucose-cultured rat Schwann cells (RSC96) showed enhanced autophagosome marker LC3-II with the treatment of lycorine.	lycorine	130-138	annexin A3	Rattus norvegicus	101-104
34863821-5	2022	Additionally, beclin-1 and Atg3 were decreased in high glucose-stimulated RSC96 cells, which were reversed by lycorine treatment.	lycorine	110-118	beclin 1	Rattus norvegicus	14-22
34863821-5	2022	Additionally, beclin-1 and Atg3 were decreased in high glucose-stimulated RSC96 cells, which were reversed by lycorine treatment.	lycorine	110-118	autophagy related 3	Rattus norvegicus	27-31
34863821-6	2022	Furthermore, DPN-associated differentially expressed genes (DEGs) from GEO datasets and lycorine-drug targets from PubChem and PharmMapper were visually analyzed and revealed that MMP9 was both DPN-associated DEGs and lycorine-drug target.	lycorine	88-96	matrix metallopeptidase 9	Rattus norvegicus	180-184
34863821-6	2022	Furthermore, DPN-associated differentially expressed genes (DEGs) from GEO datasets and lycorine-drug targets from PubChem and PharmMapper were visually analyzed and revealed that MMP9 was both DPN-associated DEGs and lycorine-drug target.	lycorine	218-226	matrix metallopeptidase 9	Rattus norvegicus	180-184
34863821-8	2022	Moreover, lycorine reduced high glucose-enhanced MMP9 expression in RSC96 cells.	lycorine	10-18	matrix metallopeptidase 9	Rattus norvegicus	49-53
34863821-9	2022	Overexpression of MMP9 attenuated lycorine-induced the expression of beclin-1, Atg3 and LC3-II in high glucose-cultured RSC96 cells.	lycorine	34-42	beclin 1	Rattus norvegicus	69-77
34863821-9	2022	Overexpression of MMP9 attenuated lycorine-induced the expression of beclin-1, Atg3 and LC3-II in high glucose-cultured RSC96 cells.	lycorine	34-42	autophagy related 3	Rattus norvegicus	79-83
34863821-9	2022	Overexpression of MMP9 attenuated lycorine-induced the expression of beclin-1, Atg3 and LC3-II in high glucose-cultured RSC96 cells.	lycorine	34-42	annexin A3	Rattus norvegicus	88-91
34863821-10	2022	In addition, AMPK pathway activation was confirmed in lycorine-treated high glucose-cultured RSC96 cells.	lycorine	54-62	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	13-17
34863821-11	2022	Then AMPK pathway inhibition attenuated lycorine-reduced MMP9 expression in high glucose-treated RSC96 cells.	lycorine	40-48	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	5-9
34863821-11	2022	Then AMPK pathway inhibition attenuated lycorine-reduced MMP9 expression in high glucose-treated RSC96 cells.	lycorine	40-48	matrix metallopeptidase 9	Rattus norvegicus	57-61
34863821-12	2022	Molecular docking analysis revealed that lycorine bound the domain of AMPK containing Thr 172 site, which affected AMPK (Thr 172) phosphorylation.	lycorine	41-49	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	70-74
34863821-12	2022	Molecular docking analysis revealed that lycorine bound the domain of AMPK containing Thr 172 site, which affected AMPK (Thr 172) phosphorylation.	lycorine	41-49	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	115-119
34863821-13	2022	Finally, AMPK pathway activation and MMP9 downregulation were also revealed in the sciatic nerves of diabetic mice administrated with lycorine.	lycorine	134-142	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	9-13
34863821-13	2022	Finally, AMPK pathway activation and MMP9 downregulation were also revealed in the sciatic nerves of diabetic mice administrated with lycorine.	lycorine	134-142	matrix metallopeptidase 9	Mus musculus	37-41
34515620-9	2021	Levels of the inflammatory cytokines, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, were increased by treatment with isoproterenol; these increases were significantly reduced by lycorine, with involvement of the NF-kappaB signaling pathway.	lycorine	195-203	interleukin 1 alpha	Mus musculus	38-60
34515620-9	2021	Levels of the inflammatory cytokines, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, were increased by treatment with isoproterenol; these increases were significantly reduced by lycorine, with involvement of the NF-kappaB signaling pathway.	lycorine	195-203	interleukin 6	Mus musculus	62-66
34515620-9	2021	Levels of the inflammatory cytokines, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, were increased by treatment with isoproterenol; these increases were significantly reduced by lycorine, with involvement of the NF-kappaB signaling pathway.	lycorine	195-203	tumor necrosis factor	Mus musculus	72-99
34515620-9	2021	Levels of the inflammatory cytokines, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, were increased by treatment with isoproterenol; these increases were significantly reduced by lycorine, with involvement of the NF-kappaB signaling pathway.	lycorine	195-203	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	229-238
34515620-12	2021	Lycorine exerted an anti-apoptotic effect as evidenced by upregulating Bcl-2 and downregulating Bax.	lycorine	0-8	B cell leukemia/lymphoma 2	Mus musculus	71-76
34515620-12	2021	Lycorine exerted an anti-apoptotic effect as evidenced by upregulating Bcl-2 and downregulating Bax.	lycorine	0-8	BCL2-associated X protein	Mus musculus	96-99
34673013-0	2021	Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma.	lycorine	52-60	cyclin dependent kinase 1	Homo sapiens	0-25
34673013-5	2021	Simultaneously, the anti-HCC effect of lycorine was comparable to that of interfering with these three genes, and lycorine significantly promoted the decrease both in protein and mRNA expression of CDK1.	lycorine	39-47	cyclin dependent kinase 1	Homo sapiens	198-202
34673013-5	2021	Simultaneously, the anti-HCC effect of lycorine was comparable to that of interfering with these three genes, and lycorine significantly promoted the decrease both in protein and mRNA expression of CDK1.	lycorine	114-122	cyclin dependent kinase 1	Homo sapiens	198-202
34673013-6	2021	Molecular validation mechanistically demonstrated that lycorine might attenuate the degradation rate of CDK1 via interaction with it, which had been confirmed by cellular thermal shift assay and drug affinity responsive targets stability assay.	lycorine	55-63	cyclin dependent kinase 1	Homo sapiens	104-108
34673013-7	2021	Taken together, these findings suggested that CDK1, CCNB1 and CCNB2 could be regarded as potential diagnostic and prognostic biomarkers for HCC, and CDK1 might serve as a promising therapeutic target for lycorine against HCC.	lycorine	204-212	cyclin dependent kinase 1	Homo sapiens	46-50
34673013-7	2021	Taken together, these findings suggested that CDK1, CCNB1 and CCNB2 could be regarded as potential diagnostic and prognostic biomarkers for HCC, and CDK1 might serve as a promising therapeutic target for lycorine against HCC.	lycorine	204-212	cyclin B1	Homo sapiens	52-57
34673013-7	2021	Taken together, these findings suggested that CDK1, CCNB1 and CCNB2 could be regarded as potential diagnostic and prognostic biomarkers for HCC, and CDK1 might serve as a promising therapeutic target for lycorine against HCC.	lycorine	204-212	cyclin B2	Homo sapiens	62-67
34673013-7	2021	Taken together, these findings suggested that CDK1, CCNB1 and CCNB2 could be regarded as potential diagnostic and prognostic biomarkers for HCC, and CDK1 might serve as a promising therapeutic target for lycorine against HCC.	lycorine	204-212	cyclin dependent kinase 1	Homo sapiens	149-153
34594422-10	2021	After lycorine treatment, the expression levels of GPX4 in RCC cells decreased, whereas those of ACSL4 increased.	lycorine	6-14	acyl-CoA synthetase long chain family member 4	Homo sapiens	97-102
34558146-0	2021	Lycorine inhibits cell proliferation and induced oxidative stress-mediated apoptosis via regulation of the JAK/STAT3 signaling pathway in HT-3 cells.	lycorine	0-8	signal transducer and activator of transcription 3	Mus musculus	111-116
34725565-5	2021	We identified dihydrolycorine, an alkaloid lycorine, as a promising inhibitor of Runx1.	lycorine	43-51	RUNX family transcription factor 1	Rattus norvegicus	81-86
34558146-4	2021	This study intended to explore whether lycorine could prevent HT-3 proliferation and induce apoptosis by targeting the JAK/STAT3 signaling cascade.	lycorine	39-47	signal transducer and activator of transcription 3	Homo sapiens	123-128
34558146-7	2021	Furthermore, we analyzed that the molecular mechanical action of lycorine considerably repressed JAK1/STAT3 transactional activation and decrease its downstream molecules Bcl-2, and enhances the expressional activity of Bax, cytochrome c, caspase 3 and 9 in HT-3 cells.	lycorine	65-73	Janus kinase 1	Mus musculus	97-101
34558146-7	2021	Furthermore, we analyzed that the molecular mechanical action of lycorine considerably repressed JAK1/STAT3 transactional activation and decrease its downstream molecules Bcl-2, and enhances the expressional activity of Bax, cytochrome c, caspase 3 and 9 in HT-3 cells.	lycorine	65-73	signal transducer and activator of transcription 3	Mus musculus	102-107
34558146-7	2021	Furthermore, we analyzed that the molecular mechanical action of lycorine considerably repressed JAK1/STAT3 transactional activation and decrease its downstream molecules Bcl-2, and enhances the expressional activity of Bax, cytochrome c, caspase 3 and 9 in HT-3 cells.	lycorine	65-73	B cell leukemia/lymphoma 2	Mus musculus	171-176
34558146-7	2021	Furthermore, we analyzed that the molecular mechanical action of lycorine considerably repressed JAK1/STAT3 transactional activation and decrease its downstream molecules Bcl-2, and enhances the expressional activity of Bax, cytochrome c, caspase 3 and 9 in HT-3 cells.	lycorine	65-73	BCL2-associated X protein	Mus musculus	220-223
34558146-7	2021	Furthermore, we analyzed that the molecular mechanical action of lycorine considerably repressed JAK1/STAT3 transactional activation and decrease its downstream molecules Bcl-2, and enhances the expressional activity of Bax, cytochrome c, caspase 3 and 9 in HT-3 cells.	lycorine	65-73	caspase 3	Mus musculus	239-254
35354475-15	2022	A clinically significant finding was that lycorine, a specific SCAP inhibitor, could reverse acquired resistance to sorafenib in vitro and in vivo.	lycorine	42-50	SREBF chaperone	Mus musculus	63-67
34440200-6	2021	We confirmed that SARS-CoV-2 RdRp replicated double-stranded RNA using immunofluorescence staining and the inhibition of RdRp activity by remdesivir and lycorine using this system.	lycorine	153-161	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	29-33
34440200-6	2021	We confirmed that SARS-CoV-2 RdRp replicated double-stranded RNA using immunofluorescence staining and the inhibition of RdRp activity by remdesivir and lycorine using this system.	lycorine	153-161	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	121-125