PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29920086-10	2018	At sufficient polymer:protein ratios, poly(ethylene glycol) diacrylate reacts with the surface cysteine on two Tri Gal-1 molecules to form Tri-PEG-Tri.	poly(ethylene glycol)diacrylate	38-70	galectin 1	Homo sapiens	115-120
30535592-7	2018	Moreover, the sulphonated modification of PEGDA hydrogel not only enhanced the attachment and proliferation of osteoblast-like MC3T3-E1 cells but also up-regulated alkaline phosphatase activity as well as gene expression of osteogenic markers and related growth factors, including collagen type I, osteocalcin, runt related transcription factor 2, bone morphogenetic protein 2, and transforming growth factor beta 1.	poly(ethylene glycol)diacrylate	42-47	bone gamma-carboxyglutamate protein 2	Mus musculus	298-309
30535592-7	2018	Moreover, the sulphonated modification of PEGDA hydrogel not only enhanced the attachment and proliferation of osteoblast-like MC3T3-E1 cells but also up-regulated alkaline phosphatase activity as well as gene expression of osteogenic markers and related growth factors, including collagen type I, osteocalcin, runt related transcription factor 2, bone morphogenetic protein 2, and transforming growth factor beta 1.	poly(ethylene glycol)diacrylate	42-47	runt related transcription factor 2	Mus musculus	311-346
30535592-7	2018	Moreover, the sulphonated modification of PEGDA hydrogel not only enhanced the attachment and proliferation of osteoblast-like MC3T3-E1 cells but also up-regulated alkaline phosphatase activity as well as gene expression of osteogenic markers and related growth factors, including collagen type I, osteocalcin, runt related transcription factor 2, bone morphogenetic protein 2, and transforming growth factor beta 1.	poly(ethylene glycol)diacrylate	42-47	bone morphogenetic protein 2	Mus musculus	348-376
30535592-7	2018	Moreover, the sulphonated modification of PEGDA hydrogel not only enhanced the attachment and proliferation of osteoblast-like MC3T3-E1 cells but also up-regulated alkaline phosphatase activity as well as gene expression of osteogenic markers and related growth factors, including collagen type I, osteocalcin, runt related transcription factor 2, bone morphogenetic protein 2, and transforming growth factor beta 1.	poly(ethylene glycol)diacrylate	42-47	transforming growth factor, beta 1	Mus musculus	382-415
28727998-5	2017	In this study, modified FKN-binding-aptamers are integrated with poly(ethylene glycol) diacrylate to form aptamer-functionalized hydrogels ("aptagels") that localize, dramatically enrich and passively release FKN in vitro for at least one week.	poly(ethylene glycol)diacrylate	65-97	chemokine (C-X3-C motif) ligand 1	Mus musculus	209-212
29505894-9	2018	When MSC-derived cells were encapsulated in PEGDA hydrogels that mimic the leaflet modulus, a decrease in alphaSMA expression and increase in vimentin was observed.	poly(ethylene glycol)diacrylate	44-49	vimentin	Homo sapiens	142-150
27120017-5	2016	Expression of the HAS1 isoform of hyaluronan synthase was significantly higher in hyaluronan hydrogels compared to blank-slate poly(ethylene glycol) diacrylate (PEGDA) hydrogels.	poly(ethylene glycol)diacrylate	127-159	hyaluronan synthase 1	Homo sapiens	18-22
28284922-4	2017	Specifically, glucose oxidase (GOX) was acrylated and co-polymerized with poly(ethylene glycol)-diacrylate (PEGDA) through photopolymerization to form GOX-immobilized PEG-based hydrogels.	poly(ethylene glycol)diacrylate	74-106	hydroxyacid oxidase 1	Homo sapiens	14-29
28284922-4	2017	Specifically, glucose oxidase (GOX) was acrylated and co-polymerized with poly(ethylene glycol)-diacrylate (PEGDA) through photopolymerization to form GOX-immobilized PEG-based hydrogels.	poly(ethylene glycol)diacrylate	74-106	hydroxyacid oxidase 1	Homo sapiens	31-34
28284922-4	2017	Specifically, glucose oxidase (GOX) was acrylated and co-polymerized with poly(ethylene glycol)-diacrylate (PEGDA) through photopolymerization to form GOX-immobilized PEG-based hydrogels.	poly(ethylene glycol)diacrylate	74-106	hydroxyacid oxidase 1	Homo sapiens	151-154
28284922-4	2017	Specifically, glucose oxidase (GOX) was acrylated and co-polymerized with poly(ethylene glycol)-diacrylate (PEGDA) through photopolymerization to form GOX-immobilized PEG-based hydrogels.	poly(ethylene glycol)diacrylate	108-113	hydroxyacid oxidase 1	Homo sapiens	14-29
28284922-4	2017	Specifically, glucose oxidase (GOX) was acrylated and co-polymerized with poly(ethylene glycol)-diacrylate (PEGDA) through photopolymerization to form GOX-immobilized PEG-based hydrogels.	poly(ethylene glycol)diacrylate	108-113	hydroxyacid oxidase 1	Homo sapiens	31-34
28284922-4	2017	Specifically, glucose oxidase (GOX) was acrylated and co-polymerized with poly(ethylene glycol)-diacrylate (PEGDA) through photopolymerization to form GOX-immobilized PEG-based hydrogels.	poly(ethylene glycol)diacrylate	108-113	hydroxyacid oxidase 1	Homo sapiens	151-154
27967655-0	2017	Encapsulation of Adenovirus BMP2-Transduced Cells with PEGDA Hydrogels Allows Bone Formation in the Presence of Immune Response.	poly(ethylene glycol)diacrylate	55-60	bone morphogenetic protein 2	Mus musculus	28-32
27967655-6	2017	Data collectively suggest that PEGDA hydrogel encapsulation of AdBMP2-transduced cells prevents pre-existing immunity from suppressing BMP2-induced bone formation.	poly(ethylene glycol)diacrylate	31-36	bone morphogenetic protein 2	Mus musculus	65-69
27120017-5	2016	Expression of the HAS1 isoform of hyaluronan synthase was significantly higher in hyaluronan hydrogels compared to blank-slate poly(ethylene glycol) diacrylate (PEGDA) hydrogels.	poly(ethylene glycol)diacrylate	161-166	hyaluronan synthase 1	Homo sapiens	18-22
26148675-3	2015	Here we report a novel method using capture antibody immobilized porous poly (ethylene) glycol diacrylate (PEGDA) hydrogel microspheres to enable high sensitivity VEGF detection in arrayed microfluidics.	poly(ethylene glycol)diacrylate	72-105	vascular endothelial growth factor A	Homo sapiens	163-167
26148675-3	2015	Here we report a novel method using capture antibody immobilized porous poly (ethylene) glycol diacrylate (PEGDA) hydrogel microspheres to enable high sensitivity VEGF detection in arrayed microfluidics.	poly(ethylene glycol)diacrylate	107-112	vascular endothelial growth factor A	Homo sapiens	163-167
25587375-8	2014	Surface patterns of the cell binding protein fibronectin were photochemically defined inside a closed microfluidic device that was initially homogeneously coated by PEGDA.	poly(ethylene glycol)diacrylate	165-170	fibronectin 1	Homo sapiens	45-56
26426006-6	2015	The experimental results thus obtained that the proliferation, ECM secretion, and differentiation of the PEGDA-BMP-2 group exceeded those of the PEGDA group during the period of cultivation.	poly(ethylene glycol)diacrylate	105-110	bone morphogenetic protein 2	Mus musculus	111-116
26426006-9	2015	These experimental results also revealed that the PEGDA-BMP-2 group had better osteogenic effects than the PEGDA group following a 12 weeks after transplantation.	poly(ethylene glycol)diacrylate	50-55	bone morphogenetic protein 2	Mus musculus	56-61
25692976-3	2015	In this study, fibrinogen-modified poly(ethylene glycol)-diacrylate (PEG-DA) based hydrogels with tunable mechanical properties were synthesized and applied to control the spheroid formation and liver-like function of encapsulated Huh7.5 cells in an engineered, three-dimensional liver tissue model.	poly(ethylene glycol)diacrylate	35-67	MIR7-3 host gene	Homo sapiens	231-235
25692976-3	2015	In this study, fibrinogen-modified poly(ethylene glycol)-diacrylate (PEG-DA) based hydrogels with tunable mechanical properties were synthesized and applied to control the spheroid formation and liver-like function of encapsulated Huh7.5 cells in an engineered, three-dimensional liver tissue model.	poly(ethylene glycol)diacrylate	69-75	MIR7-3 host gene	Homo sapiens	231-235
25692976-8	2015	Taken together, our findings establish guidelines to control the formation of Huh7.5 cell spheroids in modified PEGDA based hydrogels.	poly(ethylene glycol)diacrylate	112-117	MIR7-3 host gene	Homo sapiens	78-82
23727515-5	2013	Here, we report the fabrication and utilization of capture-antibody immobilized macro-porous poly(ethylene) glycol diacrylate (PEGDA) hydrogel microspheres for quantitative and reproducible measurement of VEGF.	poly(ethylene glycol)diacrylate	93-125	vascular endothelial growth factor A	Homo sapiens	205-209
25450405-5	2014	Guided by a computational model, we fabricated a patch composed of micro-sized VEGF-releasing poly(ethylene glycol) diacrylate (PEGDA) hydrogel cylinders using an ink-jet printer.	poly(ethylene glycol)diacrylate	94-126	vascular endothelial growth factor A	Homo sapiens	79-83
25450405-5	2014	Guided by a computational model, we fabricated a patch composed of micro-sized VEGF-releasing poly(ethylene glycol) diacrylate (PEGDA) hydrogel cylinders using an ink-jet printer.	poly(ethylene glycol)diacrylate	128-133	vascular endothelial growth factor A	Homo sapiens	79-83
24875761-0	2014	Preserved bioactivity and tunable release of a SDF1-GPVI bi-specific protein using photo-crosslinked PEGda hydrogels.	poly(ethylene glycol)diacrylate	101-106	C-X-C motif chemokine ligand 12	Homo sapiens	47-51
24875761-0	2014	Preserved bioactivity and tunable release of a SDF1-GPVI bi-specific protein using photo-crosslinked PEGda hydrogels.	poly(ethylene glycol)diacrylate	101-106	glycoprotein VI platelet	Homo sapiens	52-56
24875761-4	2014	In this study, we generated a cytocompatible hydrogel via photo-crosslinking of poly(ethylene glycol) diacrylate that serves as a reservoir for SDF1-GPVI.	poly(ethylene glycol)diacrylate	80-112	C-X-C motif chemokine ligand 12	Homo sapiens	144-148
24875761-4	2014	In this study, we generated a cytocompatible hydrogel via photo-crosslinking of poly(ethylene glycol) diacrylate that serves as a reservoir for SDF1-GPVI.	poly(ethylene glycol)diacrylate	80-112	glycoprotein VI platelet	Homo sapiens	149-153
23727515-5	2013	Here, we report the fabrication and utilization of capture-antibody immobilized macro-porous poly(ethylene) glycol diacrylate (PEGDA) hydrogel microspheres for quantitative and reproducible measurement of VEGF.	poly(ethylene glycol)diacrylate	127-132	vascular endothelial growth factor A	Homo sapiens	205-209
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	poly(ethylene glycol)diacrylate	178-210	galactosidase beta 1	Homo sapiens	13-31
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	poly(ethylene glycol)diacrylate	178-210	lactase	Homo sapiens	33-40
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	poly(ethylene glycol)diacrylate	212-217	galactosidase beta 1	Homo sapiens	13-31
23744741-3	2013	In this work beta-galactosidase (lactase) enzyme was entrapped within hydrogel matrices of acrylamide (ACR) crosslinked with N,N"-methylenebisacrylamide (BIS, non-degradable) or poly(ethylene glycol) diacrylate (PEGDA, degradable) to create "biogels."	poly(ethylene glycol)diacrylate	212-217	lactase	Homo sapiens	33-40
23744741-5	2013	As expected, the swelling rate, Ks , decreased when increasing the crosslink density from 78.6 to 14.7 min-1 over a range of 1-20 mol% PEGDA indicating that diffusivity into the matrix is dependent on crosslink density.	poly(ethylene glycol)diacrylate	135-140	CD59 molecule (CD59 blood group)	Homo sapiens	103-108
23832813-0	2013	Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres.	poly(ethylene glycol)diacrylate	86-91	bone morphogenetic protein 2	Rattus norvegicus	65-69
23914330-4	2013	Degradable PEGDA hydrogels were synthesized by incorporating a matrix metalloproteinase (MMP)-sensitive peptide, GGGPQGIWGQGK (abbreviated PQ), into the polymer backbone.	poly(ethylene glycol)diacrylate	11-16	matrix metallopeptidase 2	Homo sapiens	89-92
23319204-3	2013	For this purpose, we conjugated 3.35 kDa polyethylene glycol diacrylate (PEGDA) to human plasma fibronectin (HPFN).	poly(ethylene glycol)diacrylate	41-71	fibronectin 1	Homo sapiens	96-107
23319204-3	2013	For this purpose, we conjugated 3.35 kDa polyethylene glycol diacrylate (PEGDA) to human plasma fibronectin (HPFN).	poly(ethylene glycol)diacrylate	73-78	fibronectin 1	Homo sapiens	96-107
23527117-5	2013	METHODS: 4T1 or MCF7 breast cancer cells were encapsulated in PEGDA gel with CD44BP conjugation.	poly(ethylene glycol)diacrylate	62-67	CD44 molecule (Indian blood group)	Homo sapiens	77-81
22564496-0	2012	beta-Defensin-4 (HBD-4) is expressed in chondrocytes derived from normal and osteoarthritic cartilage encapsulated in PEGDA scaffold.	poly(ethylene glycol)diacrylate	118-123	defensin beta 104B	Homo sapiens	0-15
22564496-0	2012	beta-Defensin-4 (HBD-4) is expressed in chondrocytes derived from normal and osteoarthritic cartilage encapsulated in PEGDA scaffold.	poly(ethylene glycol)diacrylate	118-123	defensin beta 104B	Homo sapiens	17-22
22564496-3	2012	The aim of this study was to investigate beta-defensin-4 expression in chondrocytes taken from articular cartilage of knees of patients with osteoarthritis (OA) compared to normal cartilage, in vivo in explanted tissue, and in vitro in chondrocytes encapsulated in construct PEGDA hydrogels.	poly(ethylene glycol)diacrylate	275-280	defensin beta 104B	Homo sapiens	41-56
22564496-7	2012	The chondrocytes from OA cartilage after 4 weeks of culture in PEGDA hydrogels showed the formation of new hyaline cartilage and a decreased expression of beta-defensin-4 immunostaining comparable to that of control cartilage.	poly(ethylene glycol)diacrylate	63-68	defensin beta 104B	Homo sapiens	155-170
22426138-0	2012	FGF-1 and proteolytically mediated cleavage site presentation influence three-dimensional fibroblast invasion in biomimetic PEGDA hydrogels.	poly(ethylene glycol)diacrylate	124-129	fibroblast growth factor 1	Homo sapiens	0-5
22535508-0	2012	Effects of molecular weight and loading on matrix metalloproteinase-2 mediated release from poly(ethylene glycol) diacrylate hydrogels.	poly(ethylene glycol)diacrylate	92-124	matrix metallopeptidase 2	Homo sapiens	43-69
22535508-1	2012	Herein, we report on continued efforts to understand an implantable poly(ethylene glycol) diacrylate (PEGDA) hydrogel drug delivery system that responds to extracellular enzymes, in particular matrix metalloproteinase-2 (MMP-2) to provide controlled drug delivery.	poly(ethylene glycol)diacrylate	68-100	matrix metallopeptidase 2	Homo sapiens	193-219
22535508-1	2012	Herein, we report on continued efforts to understand an implantable poly(ethylene glycol) diacrylate (PEGDA) hydrogel drug delivery system that responds to extracellular enzymes, in particular matrix metalloproteinase-2 (MMP-2) to provide controlled drug delivery.	poly(ethylene glycol)diacrylate	68-100	matrix metallopeptidase 2	Homo sapiens	221-226
22535508-1	2012	Herein, we report on continued efforts to understand an implantable poly(ethylene glycol) diacrylate (PEGDA) hydrogel drug delivery system that responds to extracellular enzymes, in particular matrix metalloproteinase-2 (MMP-2) to provide controlled drug delivery.	poly(ethylene glycol)diacrylate	102-107	matrix metallopeptidase 2	Homo sapiens	193-219
22535508-1	2012	Herein, we report on continued efforts to understand an implantable poly(ethylene glycol) diacrylate (PEGDA) hydrogel drug delivery system that responds to extracellular enzymes, in particular matrix metalloproteinase-2 (MMP-2) to provide controlled drug delivery.	poly(ethylene glycol)diacrylate	102-107	matrix metallopeptidase 2	Homo sapiens	221-226
22535508-8	2012	The increase in ratio of release from PEGDA 10,000 and PEGDA 20,000 hydrogels compared to PEGDA 3,400 hydrogels suggests MMP-2 enters the hydrogel.	poly(ethylene glycol)diacrylate	38-43	matrix metallopeptidase 2	Homo sapiens	121-126
22535508-8	2012	The increase in ratio of release from PEGDA 10,000 and PEGDA 20,000 hydrogels compared to PEGDA 3,400 hydrogels suggests MMP-2 enters the hydrogel.	poly(ethylene glycol)diacrylate	55-60	matrix metallopeptidase 2	Homo sapiens	121-126
22535508-8	2012	The increase in ratio of release from PEGDA 10,000 and PEGDA 20,000 hydrogels compared to PEGDA 3,400 hydrogels suggests MMP-2 enters the hydrogel.	poly(ethylene glycol)diacrylate	55-60	matrix metallopeptidase 2	Homo sapiens	121-126
22510404-4	2012	Plasmid DNA encoding bone morphogenetic protein (BMP)-2 was delivered to fibroblasts, bone marrow stromal cells, and myoblasts cultured on fibronectin-conjugated poly(ethylene glycol) diacrylate hydrogels with varied elastic moduli, and the cellular uptake and subsequent expression of plasmid DNA were examined.	poly(ethylene glycol)diacrylate	162-194	fibronectin 1	Homo sapiens	139-150
21704737-8	2011	Fibroblasts encapsulated in PEGDA-PEGMA hydrogels displayed more significant biphasic dependencies of cell viability and vascular endothelial growth factor (VEGF) expression on E than those encapsulated in pure PEGDA hydrogels, which were greatly influenced by Q.	poly(ethylene glycol)diacrylate	28-33	vascular endothelial growth factor A	Homo sapiens	121-155
21704737-8	2011	Fibroblasts encapsulated in PEGDA-PEGMA hydrogels displayed more significant biphasic dependencies of cell viability and vascular endothelial growth factor (VEGF) expression on E than those encapsulated in pure PEGDA hydrogels, which were greatly influenced by Q.	poly(ethylene glycol)diacrylate	28-33	vascular endothelial growth factor A	Homo sapiens	157-161
21639150-3	2011	(1) Here we use a covalently immobilized ephrinA1, conjugated to poly(ethylene glycol), to induce vessel formation both in vitro and in vivo in poly(ethylene glycol) diacrylate (PEGDA) hydrogels.	poly(ethylene glycol)diacrylate	144-176	ephrin A1	Homo sapiens	41-49
21612821-0	2011	The promotion of microvasculature formation in poly(ethylene glycol) diacrylate hydrogels by an immobilized VEGF-mimetic peptide.	poly(ethylene glycol)diacrylate	47-79	vascular endothelial growth factor A	Mus musculus	108-112
21639150-3	2011	(1) Here we use a covalently immobilized ephrinA1, conjugated to poly(ethylene glycol), to induce vessel formation both in vitro and in vivo in poly(ethylene glycol) diacrylate (PEGDA) hydrogels.	poly(ethylene glycol)diacrylate	178-183	ephrin A1	Homo sapiens	41-49
21639150-7	2011	HUVECs seeded onto PEGDA hydrogels displayed a dose-dependent reduction in tubule formation in response to the soluble EphA2.	poly(ethylene glycol)diacrylate	19-24	EPH receptor A2	Homo sapiens	119-124
21282205-7	2011	By embedding MMP7 peptide substrates within a poly(ethylene glycol) diacrylate backbone, we built MMP7-sensitive hydrogels with distinct degradation rates.	poly(ethylene glycol)diacrylate	46-78	matrix metallopeptidase 7	Homo sapiens	13-17
21150701-6	2011	METHODS: TM-HA and ELP were combined in various concentrations and cross-linked using poly (ethylene glycol) diacrylate.	poly(ethylene glycol)diacrylate	86-119	nuclear receptor subfamily 5 group A member 1	Homo sapiens	19-22
21282205-7	2011	By embedding MMP7 peptide substrates within a poly(ethylene glycol) diacrylate backbone, we built MMP7-sensitive hydrogels with distinct degradation rates.	poly(ethylene glycol)diacrylate	46-78	matrix metallopeptidase 7	Homo sapiens	98-102
22073377-0	2011	Lubricin is expressed in chondrocytes derived from osteoarthritic cartilage encapsulated in poly (ethylene glycol) diacrylate scaffold.	poly(ethylene glycol)diacrylate	92-125	proteoglycan 4	Homo sapiens	0-8
22073377-4	2011	The expression levels of lubricin were studied by immunohistochemistry: i) in tissue explanted from OA and normal human cartilage; ii) in chondrocytes encapsulated in hydrogel PEGDA from OA and normal human cartilage.	poly(ethylene glycol)diacrylate	176-181	proteoglycan 4	Homo sapiens	25-33
22073377-7	2011	The chondrocytes from OA cartilage after 5 weeks of culture in hydrogels (PEGDA) showed an increased expression of lubricin compared with the control cartilage.	poly(ethylene glycol)diacrylate	74-79	proteoglycan 4	Homo sapiens	115-123
22073377-8	2011	The present study demonstrated that OA chondrocytes encapsulated in PEGDA, grown in the scaffold and were able to restore lubricin biosynthesis.	poly(ethylene glycol)diacrylate	68-73	proteoglycan 4	Homo sapiens	122-130
20673027-2	2010	We present a novel technology that delivers high BMP-2 levels at targeted locations for rapid endochondral bone formation, enhancing our preexisting cell-based gene therapy system by microencapsulating adenovirus-transduced cells in nondegradable poly(ethylene glycol) diacrylate (PEGDA) hydrogels before intramuscular delivery.	poly(ethylene glycol)diacrylate	247-279	bone morphogenetic protein 2	Mus musculus	49-54
20673027-2	2010	We present a novel technology that delivers high BMP-2 levels at targeted locations for rapid endochondral bone formation, enhancing our preexisting cell-based gene therapy system by microencapsulating adenovirus-transduced cells in nondegradable poly(ethylene glycol) diacrylate (PEGDA) hydrogels before intramuscular delivery.	poly(ethylene glycol)diacrylate	281-286	bone morphogenetic protein 2	Mus musculus	49-54
20216924-6	2010	Gradients of a cell-adhesion ligand, Arg-Gly-Asp-Ser (RGDS), was incorporated in the poly(ethylene glycol)-diacrylate (PEG-DA) hydrogels to test the response of endothelial cells.	poly(ethylene glycol)diacrylate	85-117	ral guanine nucleotide dissociation stimulator	Homo sapiens	54-58
20528671-6	2010	Alginate-ASC suspension was painted onto PEGDA surface.	poly(ethylene glycol)diacrylate	41-46	PYD and CARD domain containing	Homo sapiens	9-12
20216924-6	2010	Gradients of a cell-adhesion ligand, Arg-Gly-Asp-Ser (RGDS), was incorporated in the poly(ethylene glycol)-diacrylate (PEG-DA) hydrogels to test the response of endothelial cells.	poly(ethylene glycol)diacrylate	119-125	ral guanine nucleotide dissociation stimulator	Homo sapiens	54-58
19292677-8	2009	ALP activity of an osteoblast was significantly higher in the presence of BMP-2 released from PEGSDA hydrogel scaffolds compared to that in the presence of BMP-2 released from PEGDA scaffolds, especially after 6 days of release.	poly(ethylene glycol)diacrylate	176-181	alkaline phosphatase, placental	Homo sapiens	0-3
19292677-8	2009	ALP activity of an osteoblast was significantly higher in the presence of BMP-2 released from PEGSDA hydrogel scaffolds compared to that in the presence of BMP-2 released from PEGDA scaffolds, especially after 6 days of release.	poly(ethylene glycol)diacrylate	176-181	bone morphogenetic protein 2	Homo sapiens	156-161
17824832-7	2007	Human mesenchymal stem cells were differentiated into adipogenic cells, and encapsulated in PEG with both microchanneled and adsorbed bFGF.	poly(ethylene glycol)diacrylate	92-95	fibroblast growth factor 2	Homo sapiens	134-138
18803481-5	2009	To manipulate EC adhesion, migration, and tubulogenesis, the surface of PEGDA hydrogels was micropatterned with a cell adhesive ligand, Arg-Gly-Asp-Ser (RGDS), in desired concentrations and geometries.	poly(ethylene glycol)diacrylate	72-77	ral guanine nucleotide dissociation stimulator	Homo sapiens	153-157
19723440-0	2009	Covalently-immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly(ethylene glycol) diacrylate hydrogels.	poly(ethylene glycol)diacrylate	101-133	vascular endothelial growth factor A	Homo sapiens	23-57
19723440-6	2009	PEGylated RGDS and VEGF were then covalently immobilized in PEG-diacrylate (PEGDA) hydrogels in 2D and 3D.	poly(ethylene glycol)diacrylate	60-74	ral guanine nucleotide dissociation stimulator	Homo sapiens	10-14
19723440-6	2009	PEGylated RGDS and VEGF were then covalently immobilized in PEG-diacrylate (PEGDA) hydrogels in 2D and 3D.	poly(ethylene glycol)diacrylate	60-74	vascular endothelial growth factor A	Homo sapiens	19-23
19723440-6	2009	PEGylated RGDS and VEGF were then covalently immobilized in PEG-diacrylate (PEGDA) hydrogels in 2D and 3D.	poly(ethylene glycol)diacrylate	76-81	ral guanine nucleotide dissociation stimulator	Homo sapiens	10-14
19723440-6	2009	PEGylated RGDS and VEGF were then covalently immobilized in PEG-diacrylate (PEGDA) hydrogels in 2D and 3D.	poly(ethylene glycol)diacrylate	76-81	vascular endothelial growth factor A	Homo sapiens	19-23
19723440-7	2009	Immobilized VEGF increased endothelial cell tubulogenesis on the surface of non-degradable PEGDA hydrogels 4-fold compared to controls without the growth factor.	poly(ethylene glycol)diacrylate	91-96	vascular endothelial growth factor A	Homo sapiens	12-16
16139351-8	2006	It was found that EGMP-containing PEGDA hydrogels are able to sequester the important cell adhesion protein osteopontin, and these hydrogels promoted hMSC adhesion and spreading.	poly(ethylene glycol)diacrylate	34-39	secreted phosphoprotein 1	Homo sapiens	108-119
17340196-5	2007	The results showed that 10 million transduced fibroblasts that was the maximum number of cells feasible for encapsulation within PEG-DA 10 and 20 kDa hydrogels produced the highest amount of secreted BMP-2 protein.	poly(ethylene glycol)diacrylate	129-135	bone morphogenetic protein 2	Mus musculus	200-205
17031598-4	2006	The adhesive peptide sequences arginine-glycine-aspartic acid-serine (RGDS) and leucine-aspartic acid-valine (LDV) as well as sialyl Lewis X were bound to the surface of photopolymerized PEG diacrylate hydrogels.	poly(ethylene glycol)diacrylate	187-201	ral guanine nucleotide dissociation stimulator	Homo sapiens	70-74
16157371-4	2006	In the present work, this is accomplished by introducing poly(ethylene glycol) amino acrylate (NH2-PEG-Acr) along with other hydrogel precursors such as poly(ethylene glycol) diacrylate (PEG-DA) on the intermediate layers.	poly(ethylene glycol)diacrylate	187-193	acrosin	Homo sapiens	103-106
16157371-7	2006	The NH2-PEG-Acr monomer can be formed by coupling cysteamine to PEG-DA by a conjugate addition reaction.	poly(ethylene glycol)diacrylate	64-70	acrosin	Homo sapiens	12-15
16173790-5	2005	A model chemotherapeutic agent, cisplatin (CDDP), complexed to an MMP substrate (peptide-linker) was incorporated into poly(ethylene glycol) diacrylate hydrogel wafers having different poly(ethylene glycol) chain lengths (M(n) approximately 574 and 4000).	poly(ethylene glycol)diacrylate	119-151	matrix metallopeptidase 2	Homo sapiens	66-69
34474900-9	2021	Organotypic skins formed in vitro after 21 days with plasma/HA-SH-PEGDA hydrogels with an HA content of 0.05% w/v and a 2:1 crosslinking ratio were up to three times thicker than the plasma controls, evidencing a reduction in contraction, while they also showed better and more homogeneous keratin 10 (K10) expression in the supra-basal layer of the epidermis.	poly(ethylene glycol)diacrylate	66-71	keratin 10	Homo sapiens	290-300
15386483-9	2004	In conclusion, ATR-FTIR presents a viable means of monitoring the conversion of PEGdA functional end groups within a complex mixture.	poly(ethylene glycol)diacrylate	80-85	ATR serine/threonine kinase	Homo sapiens	15-18
15212328-3	2004	In this paper, we describe the synthesis of N-methacrylated DOPA monomers and their copolymerization with poly(ethylene glycol) diacrylate (PEG-DA) using either ultraviolet (UV) or visible light.	poly(ethylene glycol)diacrylate	106-138	progestagen associated endometrial protein	Homo sapiens	140-143
9804461-3	1998	Poly(ethylene glycol) diacrylate, prepared from end capping of poly(ethylene glycol) (molecular weights, 1,000, 2,000, and 4,000) with acryloyl chloride and benzophenone derived poly(ethylene glycol), prepared from poly(ethylene glycol) (molecular weight, 2,000) with benzoyl benzoic acid chloride as a photoinitiator, were dissolved in a buffer solution with or without basic fibroblast growth factor.	poly(ethylene glycol)diacrylate	0-32	fibroblast growth factor 2	Canis lupus familiaris	371-401
34861512-2	2022	Herein, a light-activated injectable hydrogel based on bioactive nanocomposite system is developed by incorporating Ag2S nanodots conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag2S) into biodegradable PEGDA and AIPH solution for inhibiting tumor growth, treating bacterial infection, and promoting wound healing.	poly(ethylene glycol)diacrylate	213-218	angiotensin II receptor type 1	Homo sapiens	116-120
34861512-2	2022	Herein, a light-activated injectable hydrogel based on bioactive nanocomposite system is developed by incorporating Ag2S nanodots conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag2S) into biodegradable PEGDA and AIPH solution for inhibiting tumor growth, treating bacterial infection, and promoting wound healing.	poly(ethylene glycol)diacrylate	213-218	biglycan	Homo sapiens	181-184
34861512-3	2022	Under laser irradiation, the photothermal effect mediated by Ag2S nanodots would trigger the decomposition of AIPH, generating alkyl radicals to initiate the gelation of PEGDA.	poly(ethylene glycol)diacrylate	170-175	angiotensin II receptor type 1	Homo sapiens	61-65
34474900-9	2021	Organotypic skins formed in vitro after 21 days with plasma/HA-SH-PEGDA hydrogels with an HA content of 0.05% w/v and a 2:1 crosslinking ratio were up to three times thicker than the plasma controls, evidencing a reduction in contraction, while they also showed better and more homogeneous keratin 10 (K10) expression in the supra-basal layer of the epidermis.	poly(ethylene glycol)diacrylate	66-71	keratin 10	Homo sapiens	302-305
34777608-2	2021	Previously, a Gal1 homodimer stabilized via covalent poly(ethylene glycol) diacrylate (PEGDA) cross-linking demonstrated higher activity relative to the non-covalent homodimer.	poly(ethylene glycol)diacrylate	53-85	galectin 1	Homo sapiens	14-18
34777608-2	2021	Previously, a Gal1 homodimer stabilized via covalent poly(ethylene glycol) diacrylate (PEGDA) cross-linking demonstrated higher activity relative to the non-covalent homodimer.	poly(ethylene glycol)diacrylate	87-92	galectin 1	Homo sapiens	14-18
34777608-4	2021	Results: Poly(ethylene glycol) bismaleimide (PEGbisMal) reacted with Gal1 at multiple sites with greater efficiency than PEGDA.	poly(ethylene glycol)diacrylate	121-126	galectin 1	Homo sapiens	69-73
35129966-6	2022	The PEG-DA/HA-PBA/MY (PHM) hybrid hydrogel achieved glucose-triggered MY release, efficient ROS-scavenging (>80.0%), and also reshaped the hostile oxidative wound microenvironment (reduced MDA activity and increased SOD and GSH/GSSG levels).	poly(ethylene glycol)diacrylate	4-10	superoxide dismutase 1	Homo sapiens	216-219
35532846-3	2022	Herein, by using reversible addition-fragmentation chain transfer method, an NH-based poly(hydroxyethyl methacrylate-co-N,N-dimethylaminoethyl methacrylate) and cross-linked by poly(ethylene glycol)diacrylate with pH responsiveness character was developed.	poly(ethylene glycol)diacrylate	177-208	phenylalanine hydroxylase	Homo sapiens	214-216
35613086-12	2022	CONCLUSIONS AND IMPLICATIONS: The study provides evidence that PEGDA microencapsulated canine islets reversed the signs of diabetes without immunosuppression and led to states of insulin-independence or significantly lowered insulin requirements in the recipients.	poly(ethylene glycol)diacrylate	63-68	insulin	Canis lupus familiaris	179-186
35613086-12	2022	CONCLUSIONS AND IMPLICATIONS: The study provides evidence that PEGDA microencapsulated canine islets reversed the signs of diabetes without immunosuppression and led to states of insulin-independence or significantly lowered insulin requirements in the recipients.	poly(ethylene glycol)diacrylate	63-68	insulin	Canis lupus familiaris	225-232
35600980-6	2023	Transforming growth factor-beta1 (TGF-beta1) was further incorporated into PEGDA/DAFM hydrogels, and it could be continuously released from the hydrogel.	poly(ethylene glycol)diacrylate	75-80	transforming growth factor, beta 1	Rattus norvegicus	0-32
35600980-6	2023	Transforming growth factor-beta1 (TGF-beta1) was further incorporated into PEGDA/DAFM hydrogels, and it could be continuously released from the hydrogel.	poly(ethylene glycol)diacrylate	75-80	transforming growth factor, beta 1	Rattus norvegicus	34-43
35600980-10	2023	The results showed that the implantation of PEGDA/DAFM/TGF-beta1 hydrogels effectively sealed the AF defect, prevented nucleus pulposus atrophy, retained disc height, and partially restored the biomechanical properties of disc.	poly(ethylene glycol)diacrylate	44-49	transforming growth factor, beta 1	Rattus norvegicus	55-64
35120345-7	2022	The first simulation showed that the PCL/GelMA and PCL/PEGDA scaffolds interlocking hydrogel and PCL at interface in a 1:1 ratio possessed the largest average tensile (PCL/GelMA: 80.52 kPa; PCL/PEGDA: 79.75 kPa) and compressive stress (PCL/GelMA: 74.71 kPa; PCL/PEGDA: 73.83 kPa).	poly(ethylene glycol)diacrylate	55-60	PHD finger protein 1	Homo sapiens	51-54
35120345-7	2022	The first simulation showed that the PCL/GelMA and PCL/PEGDA scaffolds interlocking hydrogel and PCL at interface in a 1:1 ratio possessed the largest average tensile (PCL/GelMA: 80.52 kPa; PCL/PEGDA: 79.75 kPa) and compressive stress (PCL/GelMA: 74.71 kPa; PCL/PEGDA: 73.83 kPa).	poly(ethylene glycol)diacrylate	55-60	PHD finger protein 1	Homo sapiens	97-100
35120345-7	2022	The first simulation showed that the PCL/GelMA and PCL/PEGDA scaffolds interlocking hydrogel and PCL at interface in a 1:1 ratio possessed the largest average tensile (PCL/GelMA: 80.52 kPa; PCL/PEGDA: 79.75 kPa) and compressive stress (PCL/GelMA: 74.71 kPa; PCL/PEGDA: 73.83 kPa).	poly(ethylene glycol)diacrylate	55-60	PHD finger protein 1	Homo sapiens	168-171
35120345-7	2022	The first simulation showed that the PCL/GelMA and PCL/PEGDA scaffolds interlocking hydrogel and PCL at interface in a 1:1 ratio possessed the largest average tensile (PCL/GelMA: 80.52 kPa; PCL/PEGDA: 79.75 kPa) and compressive stress (PCL/GelMA: 74.71 kPa; PCL/PEGDA: 73.83 kPa).	poly(ethylene glycol)diacrylate	194-199	PHD finger protein 1	Homo sapiens	37-40
35120345-7	2022	The first simulation showed that the PCL/GelMA and PCL/PEGDA scaffolds interlocking hydrogel and PCL at interface in a 1:1 ratio possessed the largest average tensile (PCL/GelMA: 80.52 kPa; PCL/PEGDA: 79.75 kPa) and compressive stress (PCL/GelMA: 74.71 kPa; PCL/PEGDA: 73.83 kPa).	poly(ethylene glycol)diacrylate	194-199	PHD finger protein 1	Homo sapiens	51-54
35120345-7	2022	The first simulation showed that the PCL/GelMA and PCL/PEGDA scaffolds interlocking hydrogel and PCL at interface in a 1:1 ratio possessed the largest average tensile (PCL/GelMA: 80.52 kPa; PCL/PEGDA: 79.75 kPa) and compressive stress (PCL/GelMA: 74.71 kPa; PCL/PEGDA: 73.83 kPa).	poly(ethylene glycol)diacrylate	262-267	PHD finger protein 1	Homo sapiens	37-40
35120345-7	2022	The first simulation showed that the PCL/GelMA and PCL/PEGDA scaffolds interlocking hydrogel and PCL at interface in a 1:1 ratio possessed the largest average tensile (PCL/GelMA: 80.52 kPa; PCL/PEGDA: 79.75 kPa) and compressive stress (PCL/GelMA: 74.71 kPa; PCL/PEGDA: 73.83 kPa).	poly(ethylene glycol)diacrylate	262-267	PHD finger protein 1	Homo sapiens	51-54
32823020-3	2020	Here, we developed a two-part repair strategy comprising a dual-modified (oxidized and methacrylated) glycosaminoglycan that can chemically adsorb an injectable interpenetrating network hydrogel composed of fibronectin-conjugated fibrin and poly (ethylene glycol) diacrylate (PEGDA) to covalently bond the hydrogel to AF tissue.	poly(ethylene glycol)diacrylate	241-274	fibronectin 1	Bos taurus	207-218
33685369-5	2021	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.	poly(ethylene glycol)diacrylate	134-139	LAP	Homo sapiens	65-68
34035420-4	2021	Moreover, the swelling ratio of the microstructure increased with increasing CNF concentration in the PEGDA hydrogel.	poly(ethylene glycol)diacrylate	102-107	NPHS1 adhesion molecule, nephrin	Homo sapiens	77-80
33464711-3	2021	An interpenetration network hydrogel is developed utilizing graphene oxide (GO)-carboxymethyl chitosan (CMC)/poly(ethylene glycol) diacrylate (PEGDA), in which two bioactive molecules, interleukin-4 (IL-4) and bone morphogenetic protein-2 (BMP-2), are loaded and released in a controlled manner to induce macrophages to differentiate into M2 type and enhance bone formation.	poly(ethylene glycol)diacrylate	109-141	interleukin 4	Homo sapiens	185-198
33191671-5	2021	In this work, RGD adhesion peptides and an antivascular endothelial growth factor receptor-2 (VEGF-R2) DNA aptamer are incorporated into a tHA-PEGDA hydrogel to make a bifunctional hyaluronic acid hydrogel.	poly(ethylene glycol)diacrylate	143-148	kinase insert domain receptor	Homo sapiens	94-101
33495508-3	2021	Our results revealed that both PEGylated BMP2 and nacre proteins induced stem cell osteodifferentiation in microscopic patterns when these proteins were covalently bonded in patterns onto polyethylene glycol diacrylate (PEGDA) hydrogel substrates; however, only nacre proteins induced mineralization localized to the micropatterns.	poly(ethylene glycol)diacrylate	188-218	bone morphogenetic protein 2	Homo sapiens	41-45
33495508-3	2021	Our results revealed that both PEGylated BMP2 and nacre proteins induced stem cell osteodifferentiation in microscopic patterns when these proteins were covalently bonded in patterns onto polyethylene glycol diacrylate (PEGDA) hydrogel substrates; however, only nacre proteins induced mineralization localized to the micropatterns.	poly(ethylene glycol)diacrylate	220-225	bone morphogenetic protein 2	Homo sapiens	41-45
33255021-5	2021	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).	poly(ethylene glycol)diacrylate	49-54	platelet and endothelial cell adhesion molecule 1	Homo sapiens	163-168
33320594-4	2020	In this study, a new strategy to construct a novel double-network biocompatible hydrogel from poly(ethylene glycol) diacrylate (PEGDA) and short-chain chitosan (CS) via ionic-covalent cross-linking is by a two-step method involving UV curing followed by immersion in an anionic solution.	poly(ethylene glycol)diacrylate	94-126	citrate synthase	Homo sapiens	161-163
33320594-4	2020	In this study, a new strategy to construct a novel double-network biocompatible hydrogel from poly(ethylene glycol) diacrylate (PEGDA) and short-chain chitosan (CS) via ionic-covalent cross-linking is by a two-step method involving UV curing followed by immersion in an anionic solution.	poly(ethylene glycol)diacrylate	128-133	citrate synthase	Homo sapiens	161-163
33320594-5	2020	The CS-based ionic network and PEGDA-based covalent network as well as the hydrogen bonds between them jointly induce excellent mechanical properties, which can be regulated by changing the PEGDA/CS content and ionic cross-linking time.	poly(ethylene glycol)diacrylate	31-36	citrate synthase	Homo sapiens	190-198
32823020-3	2020	Here, we developed a two-part repair strategy comprising a dual-modified (oxidized and methacrylated) glycosaminoglycan that can chemically adsorb an injectable interpenetrating network hydrogel composed of fibronectin-conjugated fibrin and poly (ethylene glycol) diacrylate (PEGDA) to covalently bond the hydrogel to AF tissue.	poly(ethylene glycol)diacrylate	276-281	fibronectin 1	Bos taurus	207-218
32212666-1	2020	The present article entails the generation of flexoelectricity during cantilever bending of a solid polymer electrolyte membrane (PEM), composed of poly(ethylene glycol) diacrylate (PEGDA) precursor and ionic liquid (hexylmethylimidazolium hexafluorophosphate).	poly(ethylene glycol)diacrylate	148-180	mucin 1, cell surface associated	Homo sapiens	130-133
32603082-14	2020	Gene expression of collagen II alpha1, SOX 9, and aggrecan in the ADSCs growing on the GelMA-PEGDA-RNTK scaffold increased by 79%, 52%, and 47% after three weeks, compared to the controls, respectively.	poly(ethylene glycol)diacrylate	93-98	SRY-box transcription factor 9	Homo sapiens	39-44
32212666-1	2020	The present article entails the generation of flexoelectricity during cantilever bending of a solid polymer electrolyte membrane (PEM), composed of poly(ethylene glycol) diacrylate (PEGDA) precursor and ionic liquid (hexylmethylimidazolium hexafluorophosphate).	poly(ethylene glycol)diacrylate	182-187	mucin 1, cell surface associated	Homo sapiens	130-133
32212666-3	2020	The glass transition temperature (Tg) of the PEM declines with increasing thiosiloxane amount in the PEGDA co-network, while the ionic conductivity improves.	poly(ethylene glycol)diacrylate	101-106	mucin 1, cell surface associated	Homo sapiens	45-48
31219655-5	2019	A thiol-derivatized hyaluronan hydrogel cross-linked with polyethyleneglycol diacrylate (PEGDA) was used to topically deliver a cyclized epiviosamine: cP12 and a cyclized engineered variant of cP12 termed cNP8 to porcine, full-thickness, excisional wounds.	poly(ethylene glycol)diacrylate	58-87	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	193-197
31816898-3	2019	In order to produce the dosage forms, the ratio of poly(ethylene glycol) diacrylate (PEGDA) to poly(caprolactone) triol was varied with diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (Irgacure TPO) utilized as the photoinitiator.	poly(ethylene glycol)diacrylate	85-90	thyroid peroxidase	Homo sapiens	194-197
31219655-5	2019	A thiol-derivatized hyaluronan hydrogel cross-linked with polyethyleneglycol diacrylate (PEGDA) was used to topically deliver a cyclized epiviosamine: cP12 and a cyclized engineered variant of cP12 termed cNP8 to porcine, full-thickness, excisional wounds.	poly(ethylene glycol)diacrylate	89-94	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	151-155
31219655-5	2019	A thiol-derivatized hyaluronan hydrogel cross-linked with polyethyleneglycol diacrylate (PEGDA) was used to topically deliver a cyclized epiviosamine: cP12 and a cyclized engineered variant of cP12 termed cNP8 to porcine, full-thickness, excisional wounds.	poly(ethylene glycol)diacrylate	89-94	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	193-197
30658347-0	2019	A Pyk2 inhibitor incorporated into a PEGDA-gelatin hydrogel promotes osteoblast activity and mineral deposition.	poly(ethylene glycol)diacrylate	37-42	protein tyrosine kinase 2 beta	Rattus norvegicus	2-6
30940007-3	2019	Then the CNFs/PEGDA mixture was used to fabricate 3D cytocompatibility CNFs/PEGDA hydrogel scaffold by stereolithograph(SLA)process.	poly(ethylene glycol)diacrylate	14-19	src-like adaptor	Mus musculus	120-123
30940007-3	2019	Then the CNFs/PEGDA mixture was used to fabricate 3D cytocompatibility CNFs/PEGDA hydrogel scaffold by stereolithograph(SLA)process.	poly(ethylene glycol)diacrylate	76-81	src-like adaptor	Mus musculus	120-123
30940007-6	2019	The SLA fabricated CNFs/PEGDA aerogel scaffolds possess high and tunable compressive modulus and high porosity of approximately 90%.	poly(ethylene glycol)diacrylate	24-29	src-like adaptor	Mus musculus	4-7
30658347-4	2019	In the current study, we developed a hydrogel containing poly(ethylene glycol) diacrylate (PEGDA) and gelatin which was curable by visible-light and was suitable for the delivery of small molecules, including a Pyk2-targeted chemical inhibitor.	poly(ethylene glycol)diacrylate	57-89	protein tyrosine kinase 2 beta	Rattus norvegicus	211-215
30658347-4	2019	In the current study, we developed a hydrogel containing poly(ethylene glycol) diacrylate (PEGDA) and gelatin which was curable by visible-light and was suitable for the delivery of small molecules, including a Pyk2-targeted chemical inhibitor.	poly(ethylene glycol)diacrylate	91-96	protein tyrosine kinase 2 beta	Rattus norvegicus	211-215