PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32673710-10	2020	RESULTS: Only the caecal and distal colon microbiota was able to hydrolyze and metabolize ellagitannins present in LSH to urolithins.	urolithins	122-132	helicase, lymphoid specific	Homo sapiens	115-118
34542202-4	2022	It is now obvious that urolithins can involve several cellular mechanisms including inhibition of MDM2-p53 interaction, modulation of mitogen-activated protein kinase pathway, and suppressing nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity.	urolithins	23-33	MDM2 proto-oncogene	Homo sapiens	98-102
34542202-4	2022	It is now obvious that urolithins can involve several cellular mechanisms including inhibition of MDM2-p53 interaction, modulation of mitogen-activated protein kinase pathway, and suppressing nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity.	urolithins	23-33	tumor protein p53	Homo sapiens	103-106
34542202-4	2022	It is now obvious that urolithins can involve several cellular mechanisms including inhibition of MDM2-p53 interaction, modulation of mitogen-activated protein kinase pathway, and suppressing nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity.	urolithins	23-33	nuclear factor kappa B subunit 1	Homo sapiens	256-265
34931599-4	2021	In addition, the chemical reactivity descriptors of the urolithins (Uro A, Uro B, Uro, C, Uro D) were also determined through density functional (DFT) calculations.	urolithins	56-66	uroporphyrinogen decarboxylase	Homo sapiens	90-95
32960290-6	2021	METHODS: The urolithins obtained by chemical synthesis or isolation from microbiota cultures were tested with their respective glucuronides isolated from human urine towards modulation of inflammatory response in THP-1-derived macrophages, RAW 264.7 macrophages, PBMCs-derived macrophages, and primary neutrophils.	urolithins	13-23	GLI family zinc finger 2	Homo sapiens	213-218
32306507-0	2020	Inhibition of 5-Lipoxygenase Derived Leukotrienes and Hemiketals as a Novel Anti-Inflammatory Mechanism of Urolithins.	urolithins	107-117	arachidonate 5-lipoxygenase	Homo sapiens	14-28
32832941-4	2020	Of the 16 metabolites tested, urolithins (Uro), and Uro A, in particular were the most potent, showing a modest increase in basal NF-kappaB activity and a reduction in lipopolysaccaride (LPS)-induced NF-kappaB activity, gene expression and secretion of pro-inflammatory cytokines.	urolithins	30-40	nuclear factor kappa B subunit 1	Homo sapiens	130-139
32832941-4	2020	Of the 16 metabolites tested, urolithins (Uro), and Uro A, in particular were the most potent, showing a modest increase in basal NF-kappaB activity and a reduction in lipopolysaccaride (LPS)-induced NF-kappaB activity, gene expression and secretion of pro-inflammatory cytokines.	urolithins	30-40	nuclear factor kappa B subunit 1	Homo sapiens	200-209
32640069-6	2020	Estrogen sulfotransferase and 17beta-hydroxysteroid dehydrogenase were identified as potentially subject to inhibition by the investigated urolithins.	urolithins	139-149	sulfotransferase family 1E member 1	Homo sapiens	0-25
32640069-6	2020	Estrogen sulfotransferase and 17beta-hydroxysteroid dehydrogenase were identified as potentially subject to inhibition by the investigated urolithins.	urolithins	139-149	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	30-65
32640069-9	2020	Specifically, it described, for the first time, 17beta-hydroxysteroid dehydrogenase as a target of urolithins and highlighted the need of further investigations to widen the understanding of urolithins as estrogen modulators in living organisms.	urolithins	99-109	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	48-83
32640069-9	2020	Specifically, it described, for the first time, 17beta-hydroxysteroid dehydrogenase as a target of urolithins and highlighted the need of further investigations to widen the understanding of urolithins as estrogen modulators in living organisms.	urolithins	191-201	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	48-83
32575435-6	2020	Urolithin B was found to be a better MAO-A enzyme inhibitor among the tested urolithins and EA with an IC50 value of 0.88 microM, and displaying a mixed mode of inhibition.	urolithins	77-87	monoamine oxidase A	Homo sapiens	37-42
32306507-5	2020	Urolithins, at concentrations found in the human colon (1-15 muM), decreased eicosanoid biosynthesis and COX-2 levels in the activated leukocytes.	urolithins	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	105-110
29336147-0	2018	Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-kappaB Signaling Pathways.	urolithins	0-10	mitogen-activated protein kinase 1	Mus musculus	71-75
28784051-7	2019	RESULTS: Urolithins decreased media levels of nitric oxide, interleukin 6 (IL-6), prostaglandin E2, and tumor necrosis factor alpha from LPS-BV-2 microglia.	urolithins	9-19	interleukin 6	Homo sapiens	60-73
28784051-7	2019	RESULTS: Urolithins decreased media levels of nitric oxide, interleukin 6 (IL-6), prostaglandin E2, and tumor necrosis factor alpha from LPS-BV-2 microglia.	urolithins	9-19	interleukin 6	Homo sapiens	75-79
28784051-7	2019	RESULTS: Urolithins decreased media levels of nitric oxide, interleukin 6 (IL-6), prostaglandin E2, and tumor necrosis factor alpha from LPS-BV-2 microglia.	urolithins	9-19	tumor necrosis factor	Homo sapiens	104-131
28784051-9	2019	Urolithins mitigated apoptosis and caspase 3/7 and 9 release from H2O2-induced oxidative stress of BV-2 and SH-SY5Y cells.	urolithins	0-10	caspase 3	Mus musculus	35-52
30501068-4	2018	We hypothesize that some of the human health benefits of urolithins are mediated through the aryl hydrocarbon receptor (AHR).	urolithins	57-67	aryl hydrocarbon receptor	Homo sapiens	93-118
30501068-4	2018	We hypothesize that some of the human health benefits of urolithins are mediated through the aryl hydrocarbon receptor (AHR).	urolithins	57-67	aryl hydrocarbon receptor	Homo sapiens	120-123
30501068-5	2018	Utilizing a cell-based reporter system, we tested urolithins for the capacity to modulate AHR activity.	urolithins	50-60	aryl hydrocarbon receptor	Homo sapiens	90-93
29336147-0	2018	Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-kappaB Signaling Pathways.	urolithins	0-10	thymoma viral proto-oncogene 1	Mus musculus	77-80
27490528-6	2016	Both the mix of urolithins at 5 muM and urolithin B-glucuronide at 15 muM activated eNOS expression.	urolithins	16-26	nitric oxide synthase 3	Homo sapiens	84-88
28142243-4	2017	Among the 19 metabolites tested, 3,4-dihydroxyphenylpropionic acid, 3,4-dihydroxyphenylacetic acid, gallic acid, ellagic acid, and urolithins prevented neuronal apoptosis via attenuation of ROS levels, increased REDOX activity, and decreased oxidative stress-induced apoptosis by preventing the caspase-3 activation via the mitochondrial apoptotic pathway in SH-SY5Y cells.	urolithins	131-141	caspase 3	Homo sapiens	295-304
25214070-5	2014	We investigate the role of urolithins in the regulatory mechanisms in prostate cancer, specifically those related to the androgen receptor (AR), which have been linked to the development of this type of cancer.	urolithins	27-37	androgen receptor	Homo sapiens	121-138
26891591-5	2016	Results indicated that some urolithins and ellagic acid were able to reduce the adhesion of THP-1 monocytes to human umbilical vein endothelial cells (HUVECs) and the secretion of a cellular adhesion molecule (sVCAM-1) and pro-inflammatory cytokine (IL-6).	urolithins	28-38	GLI family zinc finger 2	Homo sapiens	92-97
26891591-5	2016	Results indicated that some urolithins and ellagic acid were able to reduce the adhesion of THP-1 monocytes to human umbilical vein endothelial cells (HUVECs) and the secretion of a cellular adhesion molecule (sVCAM-1) and pro-inflammatory cytokine (IL-6).	urolithins	28-38	interleukin 6	Homo sapiens	250-254
26634414-0	2016	Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction of CDKN1A (p21) as a common mechanism involved.	urolithins	66-76	cyclin dependent kinase inhibitor 1A	Homo sapiens	174-180
26634414-0	2016	Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction of CDKN1A (p21) as a common mechanism involved.	urolithins	66-76	cyclin dependent kinase inhibitor 1A	Homo sapiens	182-185
25906041-5	2015	EA caused a slight, but significant cell cycle arrest at the G1 phase, and urolithins caused cell cycle arrest at the G2/M phase and upregulated p21 expression.	urolithins	75-85	H3 histone pseudogene 16	Homo sapiens	145-148
25214070-5	2014	We investigate the role of urolithins in the regulatory mechanisms in prostate cancer, specifically those related to the androgen receptor (AR), which have been linked to the development of this type of cancer.	urolithins	27-37	androgen receptor	Homo sapiens	140-142
25214070-7	2014	The luciferase assay performed with a construct containing three androgen response elements (AREs) showed that urolithins inhibit AR-mediated PSA expression at the transcriptional level.	urolithins	111-121	androgen receptor	Homo sapiens	93-95
25214070-8	2014	Electrophoretic mobility shift assays revealed that urolithins decreased AR binding to its consensus response element.	urolithins	52-62	androgen receptor	Homo sapiens	73-75
25214070-9	2014	Additionally, urolithins induced apoptosis in LNCaP cells, and this effect correlated with a decrease in Bcl-2 protein levels.	urolithins	14-24	BCL2 apoptosis regulator	Homo sapiens	105-110
25214070-10	2014	In summary, urolithins attenuate the function of the AR by repressing its expression, causing a down-regulation of PSA levels and inducing apoptosis.	urolithins	12-22	androgen receptor	Homo sapiens	53-55
23811531-6	2013	After the administration of urolithins and ellagic acid, we found these compounds could increase mRNA and protein expression of Phospho-p38 MAPK, and decrease mRNA and protein expression of MEKK1 and Phospho-c-Jun in T24 cells.	urolithins	28-38	mitogen-activated protein kinase 14	Homo sapiens	136-139
23811531-6	2013	After the administration of urolithins and ellagic acid, we found these compounds could increase mRNA and protein expression of Phospho-p38 MAPK, and decrease mRNA and protein expression of MEKK1 and Phospho-c-Jun in T24 cells.	urolithins	28-38	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	190-195
24969824-16	2014	Significant inhibition of TNF-alpha production was determined for all urolithins, while for the most potent urolithin A inhibition was observed at nanomolar concentrations (at 0.625 muM 29.2+-6.4% of inhibition).	urolithins	70-80	tumor necrosis factor	Homo sapiens	26-35
20642847-11	2010	Urolithins as well inhibited MMP-9 secretion and expression.	urolithins	0-10	matrix metallopeptidase 9	Homo sapiens	29-34
22648625-3	2012	Urolithins are found in plasma mostly as glucuronides at low muM concentrations.	urolithins	0-10	latexin	Homo sapiens	61-64
23811531-6	2013	After the administration of urolithins and ellagic acid, we found these compounds could increase mRNA and protein expression of Phospho-p38 MAPK, and decrease mRNA and protein expression of MEKK1 and Phospho-c-Jun in T24 cells.	urolithins	28-38	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	208-213
23586460-3	2013	This study evaluated whether urolithins (Uro-A, -B, -C, and -D) and their main phase II metabolites Uro-A sulfate, Uro-A glucuronide, and Uro-B glucuronide as well as their precursor EA were substrates for ABCG2/BCRP.	urolithins	29-39	urocortin	Homo sapiens	41-62
20338073-0	2010	NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts.	urolithins	50-60	nuclear factor kappa B subunit 1	Homo sapiens	0-9
19919114-12	2009	Thus, urolithins were found to display a dual mode mechanism by decreasing CYP1B1 activity and expression.	urolithins	6-16	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	75-81
19469472-0	2009	Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1.	urolithins	96-106	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	115-134
19469472-2	2009	EA and the urolithins, at micromolar concentrations achievable in the colon from the diet, induced the expression and activity of CYP1A1 and UGT1A10 and inhibited several sulfotransferases.	urolithins	11-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	130-136
19469472-2	2009	EA and the urolithins, at micromolar concentrations achievable in the colon from the diet, induced the expression and activity of CYP1A1 and UGT1A10 and inhibited several sulfotransferases.	urolithins	11-21	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	141-148