PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31425991-8 2019 In blend solution filtration test, membrane MS2 (1:2 for S20:SPAA6) displayed 98.22% rejection to Congo Red (CR) acid and 96.18% NaCl permeation under 1 bar. Congo Red 98-107 MS2 Homo sapiens 44-47 31831836-5 2019 We showed that FXR1 clearly colocalizes in cortical neurons with amyloid-specific dyes Congo-Red, Thioflavines S and T. FXR1 extracted from brain by immunoprecipitation shows yellow-green birefringence after staining with Congo red. Congo Red 87-96 FMR1 autosomal homolog 1 Rattus norvegicus 15-19 31831836-5 2019 We showed that FXR1 clearly colocalizes in cortical neurons with amyloid-specific dyes Congo-Red, Thioflavines S and T. FXR1 extracted from brain by immunoprecipitation shows yellow-green birefringence after staining with Congo red. Congo Red 222-231 FMR1 autosomal homolog 1 Rattus norvegicus 15-19 31831836-5 2019 We showed that FXR1 clearly colocalizes in cortical neurons with amyloid-specific dyes Congo-Red, Thioflavines S and T. FXR1 extracted from brain by immunoprecipitation shows yellow-green birefringence after staining with Congo red. Congo Red 222-231 FMR1 autosomal homolog 1 Rattus norvegicus 120-124 31398804-6 2019 Congo red staining, which binds only to Abeta oligomer plaques (amyloid), showed that there was no significant presence of plaques. Congo Red 0-9 amyloid beta precursor protein Homo sapiens 40-45 31078865-8 2019 Histopathological staining with Congo red approved the presence of Abeta plaques in these brain sections. Congo Red 32-41 amyloid beta precursor protein Rattus norvegicus 67-72 31009195-2 2019 Insoluble senile plaques of Abeta in brain tissues are commonly stained with thioflavin and congo red dyes and observed through microscopy, while those in living patient brains are detected via radioisotope-labeled fluorescence chemicals for positron emission tomography. Congo Red 92-101 amyloid beta precursor protein Homo sapiens 28-33 31253122-2 2019 The current diagnosis of ATTRv relies on genetic identification of TTR mutations and on Congo Red-positive amyloid deposits, which are absent in most ATTRv patients that are asymptomatic or early symptomatic, supporting the need for novel biomarkers to identify patients in earlier disease phases allowing disease control. Congo Red 88-97 transthyretin Homo sapiens 26-29 30901700-0 2019 Novel rare earth (RE-La, Er, Sm) metal doped ZnO photocatalysts for degradation of Congo-Red dye: Synthesis, characterization and kinetic studies. Congo Red 83-92 RELA proto-oncogene, NF-kB subunit Homo sapiens 18-23 30832884-4 2019 Congo red assay indicated that TSP-1 and TSP-2 had no triple-helix structure, which was consistent with the results of AFM. Congo Red 0-9 tumor suppressor region 1 Mus musculus 31-36 30832884-4 2019 Congo red assay indicated that TSP-1 and TSP-2 had no triple-helix structure, which was consistent with the results of AFM. Congo Red 0-9 tumor suppressor region 2 Mus musculus 41-46 31005793-6 2019 Transthyretin-related amyloidosis was demonstrated by histochemical Congo Red staining under polarized light and by immunohistochemistry, corresponding to the intimal thickening. Congo Red 68-77 transthyretin Homo sapiens 0-13 30739031-2 2019 The visible-light-induced LDH/CN/RGO ternary heterojunctions displayed significantly enhanced photocatalytic performance towards the degradation of aqueous Congo red (CR, dye) and tetracycline (TC, antibiotic) contaminants, which is far superior to that observed for pristine CN (base material), LDH, P25 (reference), and binary CN/RGO and LDH/CN heterojunctions. Congo Red 156-165 tubulin polymerization promoting protein Homo sapiens 301-304 30739031-2 2019 The visible-light-induced LDH/CN/RGO ternary heterojunctions displayed significantly enhanced photocatalytic performance towards the degradation of aqueous Congo red (CR, dye) and tetracycline (TC, antibiotic) contaminants, which is far superior to that observed for pristine CN (base material), LDH, P25 (reference), and binary CN/RGO and LDH/CN heterojunctions. Congo Red 167-169 tubulin polymerization promoting protein Homo sapiens 301-304 30840448-5 2019 In addition, benefiting from numerous exposed carbonyl and hydroxyl function groups, CPs 1-3 are applied to the adsorptive removal of dyes (congo red (CR) and methyl orange (MO)) from aqueous solutions. Congo Red 140-149 carbamoyl-phosphate synthase 1 Homo sapiens 85-90 30840448-5 2019 In addition, benefiting from numerous exposed carbonyl and hydroxyl function groups, CPs 1-3 are applied to the adsorptive removal of dyes (congo red (CR) and methyl orange (MO)) from aqueous solutions. Congo Red 151-153 carbamoyl-phosphate synthase 1 Homo sapiens 85-90 30856175-6 2019 While also critical in the response to tea tree oil, TRP1 does not avert growth inhibition due to other cell wall/membrane perturbations that activate cell wall integrity signaling such as Calcofluor White, Congo Red or heat stress. Congo Red 207-216 phosphoribosylanthranilate isomerase TRP1 Saccharomyces cerevisiae S288C 53-57 30714272-4 2019 Under in vitro conditions, PG-4 formed visible aggregates and displayed the hallmark properties of typical amyloids such as enhanced binding of Congo red, increased fluorescence with Thioflavin-T, and fibrillar morphology under transmission electron microscopy. Congo Red 144-153 protegrin-4 Sus scrofa 27-31 30087036-12 2018 Congo red staining showed that Abeta1-42 + 2-VO group rats" hippocampus CA1 had amyloid deposits from the first week to the fourth week, Abeta1-42 group were not find amyloid deposition significantly until four weeks after modeling, however, 2-VO group had no significant amyloid deposition all the time. Congo Red 0-9 carbonic anhydrase 1 Rattus norvegicus 72-75 20301373-7 1993 TTR amyloid deposition in tissue is demonstrated using Congo red staining and, ideally, immunohistochemical study. Congo Red 55-64 transthyretin Homo sapiens 0-3 30404939-4 2018 The deletion strain was also sensitive to Congo red, calcofluor white, and the antifungal drug ketoconazole, indicating that HAC1 has a role in cell wall maintenance. Congo Red 42-51 transcription factor HAC1 Saccharomyces cerevisiae S288C 125-129 29800876-5 2018 The results of filtration experiments showed that the Zr-MOFs-PUF membrane could simultaneously remove RB, MB, and CR not only from their binary system including RB/MB, RB/CR, and MB/CR mixtures, but also from RB/MB/CR ternary system. Congo Red 115-117 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 62-65 29800876-5 2018 The results of filtration experiments showed that the Zr-MOFs-PUF membrane could simultaneously remove RB, MB, and CR not only from their binary system including RB/MB, RB/CR, and MB/CR mixtures, but also from RB/MB/CR ternary system. Congo Red 172-174 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 62-65 29800876-5 2018 The results of filtration experiments showed that the Zr-MOFs-PUF membrane could simultaneously remove RB, MB, and CR not only from their binary system including RB/MB, RB/CR, and MB/CR mixtures, but also from RB/MB/CR ternary system. Congo Red 172-174 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 62-65 29800876-5 2018 The results of filtration experiments showed that the Zr-MOFs-PUF membrane could simultaneously remove RB, MB, and CR not only from their binary system including RB/MB, RB/CR, and MB/CR mixtures, but also from RB/MB/CR ternary system. Congo Red 172-174 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 62-65 29800876-7 2018 The maximum removal efficiencies by Zr-MOFs-PUF membrane were 98.80% for RB at pH 7, 97.57% for MB at pH 9, and 87.39% for CR at pH 3. Congo Red 127-129 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 44-47 29800876-8 2018 Additionally, when the NaCl concentration reached 0.5 mol/L in single dye solutions, the removal efficiencies of RB, MB, and CR by Zr-MOFs-PUF membrane were 93.08%, 79.52%, and 97.82%, respectively. Congo Red 125-127 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 139-142 29624116-5 2018 Coculture, either with human retinal pigment epithelium (ARPE) or human neural progenitor (ReN) cells, was accompanied by a significant reduction of CR labeling. Congo Red 149-151 renin Homo sapiens 91-94 30214321-5 2018 Positive staining both by anti-TGFBIp and anti-lactoferrin antibodies was observed in the Congo red-positive region. Congo Red 90-99 transforming growth factor beta induced Homo sapiens 31-37 29233914-3 2018 In addition, the had1 mutant exhibited increased sensitivity to cell wall perturbing agents, including Congo Red and Calcofluor White, and to an endoplasmic reticulum stress inducer dithiothreitol. Congo Red 104-113 solute carrier family 35 (UDP-galactose transporter), member A2 Mus musculus 17-21 29135508-11 2018 Proteomic analysis by mass spectrometry showed that the Congo red-positive material was insulin. Congo Red 56-65 insulin Homo sapiens 88-95 29425864-4 2018 Congo red assay showed development of fibril formation of insulin at acidic media at 60 C over a period of 48h. Congo Red 0-9 insulin Homo sapiens 58-65 29964850-1 2018 The linear relationship between the concentration of either bovine serum albumin (BSA) or sodium alginate (SA) and the intensity of a resonance light scattering (RLS) spectrum was established by using Congo red and neutral red as the dye probes, respectively. Congo Red 201-210 albumin Homo sapiens 67-80 30033476-6 2018 In this regard, a detailed binding profile of CR with human serum albumin (HSA) was studied using isothermal titration calorimetry (ITC) along with various spectroscopic and microscopic methods. Congo Red 46-48 albumin Homo sapiens 60-73 30197986-9 2018 Proteomic analysis of Congo red-positive amyloid deposits detected large amounts of apolipoprotein CII (APOC2) protein. Congo Red 22-31 apolipoprotein C2 Homo sapiens 84-102 30197986-9 2018 Proteomic analysis of Congo red-positive amyloid deposits detected large amounts of apolipoprotein CII (APOC2) protein. Congo Red 22-31 apolipoprotein C2 Homo sapiens 104-109 29360446-13 2018 When examined with Congo red and polarized light, the vitreous of TTR Gly83Arg mutant mice tested positive for amyloid. Congo Red 19-28 transthyretin Mus musculus 66-69 29331784-1 2018 Ternary CoFeNi-layered double hydroxide (CoFeNi-LDH) was synthesized and initially applied to activate peroxymonosulfate (PMS) for the degradation of Congo red (CR) and Rhodamine B (RhB). Congo Red 150-159 proline rich protein BstNI subfamily 1 Homo sapiens 122-125 29331784-1 2018 Ternary CoFeNi-layered double hydroxide (CoFeNi-LDH) was synthesized and initially applied to activate peroxymonosulfate (PMS) for the degradation of Congo red (CR) and Rhodamine B (RhB). Congo Red 161-163 proline rich protein BstNI subfamily 1 Homo sapiens 122-125 29331784-2 2018 The results show that the CoFeNi-LDH/PMS system can efficiently degrade nearly 100% of 20 mg/L CR or 20 mg/L RhB within 6- and 10-min reaction times, respectively. Congo Red 95-97 proline rich protein BstNI subfamily 1 Homo sapiens 26-40 29331784-6 2018 A dynamic kinetic model is successfully developed to simulate the concentration profiles of CR and RhB degradation in CoFeNi-LDH/PMS system. Congo Red 92-94 proline rich protein BstNI subfamily 1 Homo sapiens 118-132 29331784-8 2018 In addition, toxic assessment using ECOSAR program suggests that the overall toxicity of CR and RhB decreased after treatment with CoFeNi-LDH/PMS system. Congo Red 89-91 proline rich protein BstNI subfamily 1 Homo sapiens 131-145 29289724-7 2018 ecm33 did, however, display growth hypersensitivity to the dyes Calcofluor White and Congo Red, suggesting a link to cell wall integrity. Congo Red 85-94 Ecm33p Saccharomyces cerevisiae S288C 0-5 29348658-4 2018 The maximum removal capacities of 3D C-BN for methyl blue (MB) and congo red (CR) are 408 mg g-1 and 307 mg g-1, respectively. Congo Red 67-76 proline rich protein BstNI subfamily 3 Homo sapiens 93-111 29348658-4 2018 The maximum removal capacities of 3D C-BN for methyl blue (MB) and congo red (CR) are 408 mg g-1 and 307 mg g-1, respectively. Congo Red 78-80 proline rich protein BstNI subfamily 3 Homo sapiens 93-111 28396269-2 2017 Dopamine at 25muM concentration for 30h resulted in cytochrome c aggregation as evident by increase in ANS and ThT binding, structural transition from alpha helix to beta sheet and shift in congo red assay. Congo Red 190-199 cytochrome c, somatic Homo sapiens 52-64 29965208-8 2017 Ag-AgI/CN/MA-2 also showed high photoactivity for the degradation of dyes with different charges, such as rhodamine B (RhB), methyl red (MR) and congo red (CR). Congo Red 145-154 PNMA family member 2 Homo sapiens 10-14 29965208-8 2017 Ag-AgI/CN/MA-2 also showed high photoactivity for the degradation of dyes with different charges, such as rhodamine B (RhB), methyl red (MR) and congo red (CR). Congo Red 156-158 PNMA family member 2 Homo sapiens 10-14 28881300-0 2017 Kinetics and thermodynamics of bovine serum albumin interactions with Congo red dye. Congo Red 70-79 albumin Homo sapiens 38-51 28881300-2 2017 We used surface plasmon resonance (SPR) and fluorescence techniques to determine the dynamics and thermodynamic parameters for the formation of complexes between CR and bovine serum albumin (BSA). Congo Red 162-164 albumin Homo sapiens 176-189 28991784-1 2017 Magnetic imprinted N-doped P25/Fe3O4-graphene oxide (MIGNT) was prepared with methyl orange as the dummy template and pyrrole as functional monomer for catalytic degradation of Congo red (CR). Congo Red 177-186 tubulin polymerization promoting protein Homo sapiens 27-30 28991784-1 2017 Magnetic imprinted N-doped P25/Fe3O4-graphene oxide (MIGNT) was prepared with methyl orange as the dummy template and pyrrole as functional monomer for catalytic degradation of Congo red (CR). Congo Red 188-190 tubulin polymerization promoting protein Homo sapiens 27-30 28827318-7 2017 Furthermore, the recombinant N-terminal domain of MLKL forms amyloid-like fibers and binds Congo red dye. Congo Red 91-100 mixed lineage kinase domain like pseudokinase Homo sapiens 50-54 28530011-2 2017 The amount adsorbed on C/MMT reaches 0.84 g g-1 at a Congo red concentration of 1.0 g L-1, which could be attributed to their special structures and synergistic sorption. Congo Red 53-62 immunoglobulin kappa variable 1-16 Homo sapiens 86-89 28051995-7 2017 In comparison to healthy control iPS cells, we demonstrated the formation of transthyretin amyloid fibril-like structures in FAP HLC supernatants using the amyloid-specific dyes Congo red and thioflavin T. Congo Red 178-187 transthyretin Homo sapiens 77-90 28598015-11 2017 Both AL amyloidosis and 2 of 10 TTR-noPN subjects were Congo red-positive. Congo Red 55-64 transthyretin Homo sapiens 32-35 28434259-8 2017 Congo red-staining combined with fluorescence microscopy was significantly less sensitive than h-FTAA-fluorescence and TTR-immunostaining: the highest percentage area was found in TTR-immunostained sections, followed by h-FTAA and Congo red. Congo Red 0-9 transthyretin Homo sapiens 180-183 28093848-8 2017 In addition, the presence of C-terminal ATTR fragments has an impact on the affinity for various tracers used for noninvasive imaging of amyloid depositions such as 99 m-technetium-diphosphono-propanodicarboxylic acid scintigraphy and positron emission tomography utilizing Pittsburgh component B, and even for the gold standard diagnostic procedure, tissue biopsy stained by Congo red and examined under polarized light. Congo Red 376-385 transthyretin Homo sapiens 40-44 28049649-6 2017 Proteomic analysis of Congo red-positive renal and GI amyloid deposits detected abundant lysozyme C protein. Congo Red 22-31 lysozyme Homo sapiens 89-99 28117590-6 2017 Congo red assay showed that MC-2 possesses a triple-helix conformation. Congo Red 0-9 melanocortin 5 receptor Homo sapiens 28-32 27297947-5 2017 Proteomic analysis of Congo red-positive deposits detected large amounts of the Apo-CII protein. Congo Red 22-31 apolipoprotein C2 Homo sapiens 80-87 27372574-4 2016 For the detection of P-Selectin which is a crucial indicator for evaluating thrombus diseases in clinic, the "beta-sheet and Congo Red" mode significantly decreases both the error variance and the LOD (from 9.7ng/ml to 1.1 ng/ml) of detection, compared with commercial ELISA (an existing gold-standard method for detecting P-Selectin in clinic). Congo Red 125-134 selectin P Homo sapiens 21-31 27372574-4 2016 For the detection of P-Selectin which is a crucial indicator for evaluating thrombus diseases in clinic, the "beta-sheet and Congo Red" mode significantly decreases both the error variance and the LOD (from 9.7ng/ml to 1.1 ng/ml) of detection, compared with commercial ELISA (an existing gold-standard method for detecting P-Selectin in clinic). Congo Red 125-134 selectin P Homo sapiens 323-333 26701064-10 2016 Furthermore, microautoradiography confirmed that RAGE VC1 bound specifically to areas of Congo red-positive amyloid in mouse tissues but not in comparable tissues from control WT mice. Congo Red 89-98 advanced glycosylation end product-specific receptor Mus musculus 49-53 27365127-6 2016 Turbidity, Rayleigh scattering analysis, Congo red assay and ThT measurements supported the TEM data i.e. the formation of fibrillar structure of human alpha-synuclein upon 12 h incubation. Congo Red 41-50 synuclein alpha Homo sapiens 152-167 27471061-2 2016 In this work, a core-shell heterostructure of CoFe2 O4 -Zeolitic Imidazolate Framework-8 (ZIF-8@CoFe2 O4 ) is successfully fabricated and used as an solid-phase extraction adsorbent to efficiently extract Congo Red and Basic Red 2 dyes from contaminated aqueous solution. Congo Red 205-214 adenosine deaminase RNA specific B2 (inactive) Homo sapiens 225-230 27057929-6 2016 Dense Abeta aggregates (Congo red and ThT-positive) were obtained inside the collagen matrix with a homogeneous distribution and dimensions similar to those observed in post-mortem brain slices from Alzheimer"s patients. Congo Red 24-33 amyloid beta precursor protein Homo sapiens 6-11 27129292-2 2016 In the present study, we report that smooth muscle titin (SMT; 500 kDa) from chicken gizzard forms amyloid aggregates in vitro This conclusion is supported by EM data, fluorescence analysis using thioflavin T (ThT), Congo red (CR) spectroscopy and X-ray diffraction. Congo Red 216-225 titin Bos taurus 51-56 27129292-2 2016 In the present study, we report that smooth muscle titin (SMT; 500 kDa) from chicken gizzard forms amyloid aggregates in vitro This conclusion is supported by EM data, fluorescence analysis using thioflavin T (ThT), Congo red (CR) spectroscopy and X-ray diffraction. Congo Red 227-229 titin Bos taurus 51-56 26235241-6 2016 Iba1 immunohistochemistry revealed increased cell density and immunoreactive area in PDAPP mice from 9 m onward selectively in the hilus, in coincidence with prominent amyloid Congo red + deposition. Congo Red 176-187 induction of brown adipocytes 1 Mus musculus 0-4 26454182-0 2016 Sono-intercalation of CdS nanoparticles into the layers of titanate facilitates the sunlight degradation of Congo red. Congo Red 108-117 CDP-diacylglycerol synthase 1 Homo sapiens 22-25 26952083-1 2016 Diazo dye Congo Red (CR) solutions at 100mg/L, were degraded using different supporting electrolytes in an electrochemical advanced oxidation process (EAOPs), like the anodic oxidation (AOx/BDD). Congo Red 10-19 acyl-CoA oxidase 1 Homo sapiens 186-189 26952083-1 2016 Diazo dye Congo Red (CR) solutions at 100mg/L, were degraded using different supporting electrolytes in an electrochemical advanced oxidation process (EAOPs), like the anodic oxidation (AOx/BDD). Congo Red 21-23 acyl-CoA oxidase 1 Homo sapiens 186-189 27444354-5 2016 TN-C plaques completely overlapped and surrounded cored Abeta plaques labeled with X-34, a fluorescent derivative of Congo red, and they were associated with reactive astrocytes astrocytes, microglia and phosphorylated tau-containing dystrophic neurites. Congo Red 117-126 tenascin C Homo sapiens 0-4 26657584-7 2016 The formation of beta-lg self-assembly was confirmed by Thioflavin T studies, Congo red assay, Rayleigh scattering and dynamic light scattering analysis. Congo Red 78-87 beta-lactoglobulin Bos taurus 17-24 27586184-2 2016 The global conformational changes in Hb in the presence of ACN were studied using intrinsic fluorescence experiments, acrylamide quenching, ANS fluorescence measurements, soret absorbance spectroscopy, fourier transform infrared spectroscopy, circular dichroism, thioflavin T and congo red assay. Congo Red 280-289 apoptotic chromatin condensation inducer 1 Homo sapiens 59-62 27228663-1 2016 By means of spectrophotometric assay we investigated interaction of the dye Congo red (CR) with fibrils of model proteins--hen egg white lysozyme, recombinant human beta2-microglobulin (b2M) and recombinant human transthyretin (TTR). Congo Red 76-85 lysozyme Homo sapiens 137-145 27228663-1 2016 By means of spectrophotometric assay we investigated interaction of the dye Congo red (CR) with fibrils of model proteins--hen egg white lysozyme, recombinant human beta2-microglobulin (b2M) and recombinant human transthyretin (TTR). Congo Red 76-85 beta-2-microglobulin Homo sapiens 165-184 27228663-1 2016 By means of spectrophotometric assay we investigated interaction of the dye Congo red (CR) with fibrils of model proteins--hen egg white lysozyme, recombinant human beta2-microglobulin (b2M) and recombinant human transthyretin (TTR). Congo Red 76-85 transthyretin Homo sapiens 213-226 27228663-1 2016 By means of spectrophotometric assay we investigated interaction of the dye Congo red (CR) with fibrils of model proteins--hen egg white lysozyme, recombinant human beta2-microglobulin (b2M) and recombinant human transthyretin (TTR). Congo Red 76-85 transthyretin Homo sapiens 228-231 27228663-1 2016 By means of spectrophotometric assay we investigated interaction of the dye Congo red (CR) with fibrils of model proteins--hen egg white lysozyme, recombinant human beta2-microglobulin (b2M) and recombinant human transthyretin (TTR). Congo Red 87-89 lysozyme Homo sapiens 137-145 27228663-1 2016 By means of spectrophotometric assay we investigated interaction of the dye Congo red (CR) with fibrils of model proteins--hen egg white lysozyme, recombinant human beta2-microglobulin (b2M) and recombinant human transthyretin (TTR). Congo Red 87-89 beta-2-microglobulin Homo sapiens 165-184 27228663-5 2016 According to the data on titration of fibril solutions with excess of the dye, CR binds to lysozyme fibrils at a ratio of about 5 molecules per protein monomer within fibril structure, to b2M fibrils--about 4 molecules per monomer, to TTR fibrils--about 4 molecules per subunit of the protein. Congo Red 79-81 lysozyme Homo sapiens 91-99 27228663-5 2016 According to the data on titration of fibril solutions with excess of the dye, CR binds to lysozyme fibrils at a ratio of about 5 molecules per protein monomer within fibril structure, to b2M fibrils--about 4 molecules per monomer, to TTR fibrils--about 4 molecules per subunit of the protein. Congo Red 79-81 transthyretin Homo sapiens 235-238 26359500-6 2015 Similarly, structural analyses using Congo red staining, circular dichroism, and atomic force microscopy revealed that GAPDH aggregates induced Abeta40 amyloidogenesis. Congo Red 37-46 glyceraldehyde-3-phosphate dehydrogenase Mus musculus 119-124 26656730-5 2015 These EP2-derivated nanofibers promptly accelerated the formation of semen amyloid fibrils by PAP248-286, as shown by Thioflavin T (ThT) and Congo red assays. Congo Red 141-150 sperm associated antigen 11B Homo sapiens 6-9 25935672-8 2015 Peptides for SAA and AL were detected by MALDI IMS associated to Congo red-positive areas. Congo Red 65-74 serum amyloid A1 cluster Homo sapiens 13-16 26455975-7 2015 CONCLUSIONS: Transthyretin amyloidosis is usually confirmed with positive Congo red staining for amyloid identified by biopsy of peripheral nerves, salivary glands, or abdominal fat. Congo Red 74-83 transthyretin Homo sapiens 13-26 25935672-10 2015 Serum amyloid P component, apolipoprotein E, and vitronectin proteins were identified in both AA and AL amyloidosis, showing a strong correlation with Congo red-positive regions. Congo Red 151-160 amyloid P component, serum Homo sapiens 0-25 25935672-10 2015 Serum amyloid P component, apolipoprotein E, and vitronectin proteins were identified in both AA and AL amyloidosis, showing a strong correlation with Congo red-positive regions. Congo Red 151-160 vitronectin Homo sapiens 49-60 24962395-1 2014 Poly(ethylene glycol) (PEG)-decorated polystyrene (PS) nanoparticles with mean hydrodynamic diameter (D) and zeta-potential (zeta) of (286 +- 15) nm and (-50 +- 5) mV, respectively, were modified by the adsorption of Congo red (CR). Congo Red 217-226 progestagen associated endometrial protein Homo sapiens 23-26 25449759-8 2015 The level of phosphorylated Slt2 increased significantly after CR treatment in Deltaptc1 cells and more so in Deltaptc1Deltaptc6 cells; therefore, deletion of PTC6 enhanced Slt2 phosphorylation in the Deltaptc1 disruptant. Congo Red 63-65 mitogen-activated serine/threonine-protein kinase SLT2 Saccharomyces cerevisiae S288C 28-32 25449759-8 2015 The level of phosphorylated Slt2 increased significantly after CR treatment in Deltaptc1 cells and more so in Deltaptc1Deltaptc6 cells; therefore, deletion of PTC6 enhanced Slt2 phosphorylation in the Deltaptc1 disruptant. Congo Red 63-65 type 2C protein phosphatase PTC6 Saccharomyces cerevisiae S288C 159-163 25449759-9 2015 The level of transcription of KDX1 upon exposure to CR increased to a greater extent in the Deltaptc1Deltaptc6 double disruptant than the Deltaptc1 single disruptant. Congo Red 52-54 putative protein kinase KDX1 Saccharomyces cerevisiae S288C 30-34 25459675-13 2015 The signal decrease resulted from the binding of the DDNP-SPIO nanoparticles to the Abeta plaques, which was identified with Congo red and Prussian blue staining. Congo Red 125-134 amyloid beta precursor protein Rattus norvegicus 84-89 26056983-1 2015 Congo red (CR), one of the most commonly used dyes for the identification of amyloid fibril aggregates, is also a ligand of native bovine serum albumin (BSA). Congo Red 0-9 albumin Homo sapiens 138-151 26056983-1 2015 Congo red (CR), one of the most commonly used dyes for the identification of amyloid fibril aggregates, is also a ligand of native bovine serum albumin (BSA). Congo Red 11-13 albumin Homo sapiens 138-151 24758012-4 2014 The adsorption isotherms of heavy metals and dyes on the microfibers are well described by the Langmuir model, in which the estimated adsorption capacities are 14.5, 29.9, 68.3 and 110.4 mg/g for Pb(II), As(V), Congo red and methylene blue, respectively. Congo Red 211-220 submaxillary gland androgen regulated protein 3B Homo sapiens 196-202 24981510-6 2014 Furthermore, the loss of Gas1 or Congo red treatment lowers the cAMP-dependent protein kinase (PKA) activity in a cell wall integrity MAP kinase Slt2-dependent manner. Congo Red 33-42 mitogen-activated serine/threonine-protein kinase SLT2 Saccharomyces cerevisiae S288C 145-149 24962395-1 2014 Poly(ethylene glycol) (PEG)-decorated polystyrene (PS) nanoparticles with mean hydrodynamic diameter (D) and zeta-potential (zeta) of (286 +- 15) nm and (-50 +- 5) mV, respectively, were modified by the adsorption of Congo red (CR). Congo Red 228-230 progestagen associated endometrial protein Homo sapiens 23-26 24465508-5 2014 There was a small but significant reduction in Abeta levels, and the abundance of congo-red stained plaques, in brains of 12 week old mice lacking flotillin 1. Congo Red 82-91 flotillin 1 Mus musculus 147-158 24820272-7 2014 The effect of Abeta and PP on the hippocampus cells was observed by HE and Congo red staining of methanol. Congo Red 75-84 amyloid beta precursor protein Rattus norvegicus 14-19 24820272-12 2014 More positive staining materials aggradated in the Abeta group compared with the PP group by Congo red staining (P<0.05). Congo Red 93-102 amyloid beta precursor protein Rattus norvegicus 51-56 24670442-4 2014 RESULTS: Congo red staining revealed the presence of Abeta deposition in both the hippocampus and the cerebellum of the transgenic mice but not in the control mice. Congo Red 9-18 amyloid beta (A4) precursor protein Mus musculus 53-58 24667368-4 2014 PCA could significantly reduce the number of Abeta positive expressions in the hippocampus and cerebral cortex of AbetaPP/PS1 mice by immunocytochemical assay with Congo red staining and decrease remarkably APP expression level by Western blot analysis (P<0.01). Congo Red 164-173 amyloid beta (A4) precursor protein Mus musculus 45-50 24667368-4 2014 PCA could significantly reduce the number of Abeta positive expressions in the hippocampus and cerebral cortex of AbetaPP/PS1 mice by immunocytochemical assay with Congo red staining and decrease remarkably APP expression level by Western blot analysis (P<0.01). Congo Red 164-173 amyloid beta (A4) precursor protein Mus musculus 114-121 24333392-2 2014 The polymer-modified composites were characterized by FTIR, TEM, TGA, XRD and VSM, and showed excellent adsorption efficiency for CR. Congo Red 130-132 T-box transcription factor 1 Homo sapiens 65-68 24112789-4 2014 Here, we show that Abeta and gramicidin form aggregates enriched in beta-sheet structures using electron microscopy, and Thioflavin and Congo Red staining techniques. Congo Red 136-145 amyloid beta precursor protein Homo sapiens 19-24 23664546-3 2013 The presence of serum amyloid A protein was confirmed by laser microdissection of Congo Red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry; this analysis excluded hereditary and familial amyloidosis. Congo Red 82-91 serum amyloid A1 Homo sapiens 16-39 23650245-5 2013 Incorporating a clinically used Abeta fibril-staining dye, congo red (CR), into the hybrid colloidal spheres, the nanoparticles can also act as an effective fluorescent probe to monitor the inhibition process of POM@P via CR fluorescence change in real time. Congo Red 59-68 amyloid beta (A4) precursor protein Mus musculus 32-37 23650245-5 2013 Incorporating a clinically used Abeta fibril-staining dye, congo red (CR), into the hybrid colloidal spheres, the nanoparticles can also act as an effective fluorescent probe to monitor the inhibition process of POM@P via CR fluorescence change in real time. Congo Red 70-72 amyloid beta (A4) precursor protein Mus musculus 32-37 23650245-5 2013 Incorporating a clinically used Abeta fibril-staining dye, congo red (CR), into the hybrid colloidal spheres, the nanoparticles can also act as an effective fluorescent probe to monitor the inhibition process of POM@P via CR fluorescence change in real time. Congo Red 222-224 amyloid beta (A4) precursor protein Mus musculus 32-37 24040106-9 2013 In addition, Uth1p affects cell sensitivity to compounds influencing cell wall composition and integrity (such as Calcofluor white and Congo red) differently when growing on fermentative versus respiratory carbon sources. Congo Red 135-144 SUN family protein UTH1 Saccharomyces cerevisiae S288C 13-18 23420569-4 2013 Phagocytic activity of PRL was determined in treated cells by optical microscopy observation of phagocytized Congo red-stained yeast. Congo Red 109-118 prolactin Salmo salar 23-26 23584594-6 2013 The results of thioflavin T and Congo red assays suggest the existence of a significant quantity of amyloid-like entities in the sample of reduced glycated insulin adduct. Congo Red 32-41 insulin Homo sapiens 156-163 22938848-3 2013 Laser microdissection of the Congo Red-positive glomeruli followed by mass spectrometry studies showed a large number of spectra matching apolipoprotein E, serum amyloid P component, and gelsolin, consistent with a diagnosis of gelsolin-associated renal amyloidosis. Congo Red 29-38 apolipoprotein E Homo sapiens 138-154 23636660-1 2013 Because Congo red (CR) can bind to critical intermediate structural forms of amyloid beta (Abeta), it has been suggested as a potential therapeutic agent against neurodegenerative disorders such as Alzheimer"s disease. Congo Red 8-17 amyloid beta precursor protein Homo sapiens 77-89 23636660-1 2013 Because Congo red (CR) can bind to critical intermediate structural forms of amyloid beta (Abeta), it has been suggested as a potential therapeutic agent against neurodegenerative disorders such as Alzheimer"s disease. Congo Red 8-17 amyloid beta precursor protein Homo sapiens 91-96 23636660-1 2013 Because Congo red (CR) can bind to critical intermediate structural forms of amyloid beta (Abeta), it has been suggested as a potential therapeutic agent against neurodegenerative disorders such as Alzheimer"s disease. Congo Red 19-21 amyloid beta precursor protein Homo sapiens 77-89 23636660-1 2013 Because Congo red (CR) can bind to critical intermediate structural forms of amyloid beta (Abeta), it has been suggested as a potential therapeutic agent against neurodegenerative disorders such as Alzheimer"s disease. Congo Red 19-21 amyloid beta precursor protein Homo sapiens 91-96 23636660-3 2013 Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. Congo Red 60-62 amyloid beta precursor protein Homo sapiens 66-71 23636660-3 2013 Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. Congo Red 60-62 amyloid beta precursor protein Homo sapiens 140-145 23636660-3 2013 Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. Congo Red 60-62 amyloid beta precursor protein Homo sapiens 140-145 23636660-3 2013 Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. Congo Red 137-139 amyloid beta precursor protein Homo sapiens 66-71 23636660-3 2013 Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. Congo Red 137-139 amyloid beta precursor protein Homo sapiens 140-145 23636660-3 2013 Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. Congo Red 137-139 amyloid beta precursor protein Homo sapiens 140-145 23636660-3 2013 Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. Congo Red 137-139 amyloid beta precursor protein Homo sapiens 66-71 23636660-3 2013 Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. Congo Red 137-139 amyloid beta precursor protein Homo sapiens 140-145 23636660-3 2013 Studies conducted between 15 and 35 C show that binding of CR to Abeta(12-28) was strongly dependent on temperature, with a decrease in CR-Abeta(12-28) complexation as temperature increases, presumably because of conformational changes within Abeta(12-28) at the highest temperatures, that conceal the CR binding sites. Congo Red 137-139 amyloid beta precursor protein Homo sapiens 140-145 23636660-4 2013 In fact, no CR binding was observed at 35 C. The binding of CR to Abeta(12-28) was associated with favorable changes in both enthalpy and entropy that resulted in binding constants (K) of between 10(5) and 10(6) M (-1). Congo Red 61-63 amyloid beta precursor protein Homo sapiens 67-72 23480430-3 2013 Two red dyes, Allura Red AC and Congo Red, were detected with a 532 nm pulsed laser at a 5 nM limit of detection in a detection volume of less than 1 muL, corresponding to a minimal detectable absorbance of less than 4 x 10(-4) cm(-1) and a minimal detectable change in absorption cross section, sigma(min) = V(det) x epsilon x C(LOD), of about 14 mum(2) (Allura Red AC) and 37 mum(2) (Congo Red). Congo Red 32-41 tripartite motif containing 37 Homo sapiens 150-153 23403086-2 2013 Results from Congo red spectral-shift assays reveal that all four compounds successfully inhibit association of Abeta monomers. Congo Red 13-22 amyloid beta precursor protein Homo sapiens 112-117 22938848-3 2013 Laser microdissection of the Congo Red-positive glomeruli followed by mass spectrometry studies showed a large number of spectra matching apolipoprotein E, serum amyloid P component, and gelsolin, consistent with a diagnosis of gelsolin-associated renal amyloidosis. Congo Red 29-38 gelsolin Homo sapiens 187-195 22938848-3 2013 Laser microdissection of the Congo Red-positive glomeruli followed by mass spectrometry studies showed a large number of spectra matching apolipoprotein E, serum amyloid P component, and gelsolin, consistent with a diagnosis of gelsolin-associated renal amyloidosis. Congo Red 29-38 gelsolin Homo sapiens 228-236 23149115-5 2013 opy2 mutants display susceptibility to cell wall disturbing compounds like Congo red. Congo Red 75-84 Opy2p Saccharomyces cerevisiae S288C 0-4 23555730-7 2013 Congo red staining followed a similar trend revealing significant decreases in the hippocampus and the cortex for NEP-n and NEP-s treatment groups. Congo Red 0-9 nephrocan Mus musculus 114-119 22854213-6 2013 The rat amylin fibrils have a uniform structure and bind Congo red suggesting that they are amyloid fibrils. Congo Red 57-66 islet amyloid polypeptide Rattus norvegicus 8-14 23058290-1 2012 Small organic molecules, like Congo red and lacmoid, have been shown to modulate the self-assembly of the amyloid beta peptide (Abeta). Congo Red 30-39 amyloid beta precursor protein Homo sapiens 128-133 22981725-9 2012 Compared to the control compound Congo red (CR), the binding responses of RES to monomer Abeta(1-42) and Abeta(1-40) were stronger, but binding to fibril Abeta(1-42) was weaker, and the K(D)s of RES with both monomer and fibril Abeta(1-40) and Abeta(1-42) were higher than that of CR. Congo Red 33-42 amyloid beta precursor protein Homo sapiens 89-94 23058290-2 2012 Here, we show that Abeta forms NMR invisible non-toxic co-aggregates together with lacmoid as well as Congo red. Congo Red 102-111 amyloid beta precursor protein Homo sapiens 19-24 22595040-6 2012 Congo red staining showed that Abeta neuropathology of transgenic mice aggravated with age, and the 3-month-old transgenic mice started to have minimum brain Abeta plaques, corresponding to the early stage of AD phenotype. Congo Red 0-9 amyloid beta (A4) precursor protein Mus musculus 31-36 22836718-6 2012 Staining with Congo Red showed that glycolaldehyde- and acrolein-fibrinogen distinctly formed amyloid-like aggregations. Congo Red 14-23 fibrinogen beta chain Homo sapiens 65-75 23065846-4 2012 This osmotic dependency in HM-1 susceptibility was similar to those observed in Congo red, but different from those observed in other cell wall-disturbing agents. Congo Red 80-89 small nuclear ribonucleoprotein U11/U12 subunit 35 Homo sapiens 27-31 22978652-8 2012 Furthermore, this compound, subsequently identified as the bis-azo dye Congo red (CR), was able to competitively inhibit hPOT1 binding to telomeric DNA. Congo Red 71-80 protection of telomeres 1 Homo sapiens 121-126 22978652-8 2012 Furthermore, this compound, subsequently identified as the bis-azo dye Congo red (CR), was able to competitively inhibit hPOT1 binding to telomeric DNA. Congo Red 82-84 protection of telomeres 1 Homo sapiens 121-126 22978652-9 2012 Isothermal titration calorimetry and NMR chemical shift analysis suggest that CR interacts specifically with the ssDNA-binding cleft of Pot1, and that alteration of this surface disrupts CR binding. Congo Red 78-80 protection of telomeres 1 Homo sapiens 136-140 22978652-9 2012 Isothermal titration calorimetry and NMR chemical shift analysis suggest that CR interacts specifically with the ssDNA-binding cleft of Pot1, and that alteration of this surface disrupts CR binding. Congo Red 187-189 protection of telomeres 1 Homo sapiens 136-140 22817896-5 2012 The endogenous RIP1/RIP3 complex isolated from necrotic cells binds ThT, is ultrastable, and has a fibrillar core structure, whereas necrosis is partially inhibited by ThT, CR, and another amyloid dye, HBX. Congo Red 173-175 receptor interacting serine/threonine kinase 1 Homo sapiens 15-19 22817896-5 2012 The endogenous RIP1/RIP3 complex isolated from necrotic cells binds ThT, is ultrastable, and has a fibrillar core structure, whereas necrosis is partially inhibited by ThT, CR, and another amyloid dye, HBX. Congo Red 173-175 receptor interacting serine/threonine kinase 3 Homo sapiens 20-24 22506915-4 2012 Moreover, MAb ATTR indeed showed the high consistency with Congo red positive areas in tissue specimens from FAP ATTR V30M patients, indicating that MAb ATTR showed binding affinity and specificity for TTR amyloid fibrils in vitro and in vivo. Congo Red 59-68 transthyretin Homo sapiens 14-18 22492205-4 2012 The deletion of OST3 in the rot1-1 mutant causes a temperature sensitive phenotype as well as sensitivity toward compounds interfering with cell wall biogenesis such as Calcofluor White, caffeine, Congo Red and hygromycin B, whereas the deletion of OST6, a functional homolog of OST3, has no effect. Congo Red 197-206 dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 Saccharomyces cerevisiae S288C 16-20 22492205-4 2012 The deletion of OST3 in the rot1-1 mutant causes a temperature sensitive phenotype as well as sensitivity toward compounds interfering with cell wall biogenesis such as Calcofluor White, caffeine, Congo Red and hygromycin B, whereas the deletion of OST6, a functional homolog of OST3, has no effect. Congo Red 197-206 Rot1p Saccharomyces cerevisiae S288C 28-34 22506915-4 2012 Moreover, MAb ATTR indeed showed the high consistency with Congo red positive areas in tissue specimens from FAP ATTR V30M patients, indicating that MAb ATTR showed binding affinity and specificity for TTR amyloid fibrils in vitro and in vivo. Congo Red 59-68 transthyretin Homo sapiens 113-117 22506915-4 2012 Moreover, MAb ATTR indeed showed the high consistency with Congo red positive areas in tissue specimens from FAP ATTR V30M patients, indicating that MAb ATTR showed binding affinity and specificity for TTR amyloid fibrils in vitro and in vivo. Congo Red 59-68 transthyretin Homo sapiens 113-117 22506915-4 2012 Moreover, MAb ATTR indeed showed the high consistency with Congo red positive areas in tissue specimens from FAP ATTR V30M patients, indicating that MAb ATTR showed binding affinity and specificity for TTR amyloid fibrils in vitro and in vivo. Congo Red 59-68 transthyretin Homo sapiens 15-18 22391973-2 2012 We term this assay "Congo Red Analysis of Cellulose Concentration," or "CRACC." Congo Red 20-29 SLAM family member 7 Homo sapiens 72-77 22242826-0 2012 Monomeric alpha-synuclein binds Congo Red micelles in a disordered manner. Congo Red 32-41 synuclein alpha Homo sapiens 10-25 22242826-1 2012 The histological dye Congo Red (CR) previously has been shown to inhibit alpha-synuclein (aS) fibrillation, but the mode of this inhibition remained unclear. Congo Red 21-30 synuclein alpha Homo sapiens 73-88 22242826-1 2012 The histological dye Congo Red (CR) previously has been shown to inhibit alpha-synuclein (aS) fibrillation, but the mode of this inhibition remained unclear. Congo Red 32-34 synuclein alpha Homo sapiens 73-88 22038516-9 2012 Inhibition of islet amyloid formation with Congo Red reduced beta cell apoptosis and partially decreased JNK activation. Congo Red 43-52 mitogen-activated protein kinase 8 Homo sapiens 105-108 22220313-8 2004 Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes. Congo Red 79-88 amyloid beta precursor protein Homo sapiens 23-28 22702727-3 2012 Both prevention and promotion of Abeta aggregation have been proposed, suggesting that CR may interact with Abeta of different structural conformations resulting in different effects on Abeta aggregation behavior. Congo Red 87-89 amyloid beta precursor protein Homo sapiens 33-38 22702727-7 2012 CR can interact with the helical form of Abeta(40), and the main interaction site is located at the first helical and hydrophobic core region, residues 17-25, which is assigned as a discordant helix region. Congo Red 0-2 amyloid beta precursor protein Homo sapiens 41-46 22702727-8 2012 Furthermore, CR may prevent Abeta(40) undergoing alpha-helix to beta-strand conversion, and therefore aggregation through stabilizing the helical conformation of discordant helix in SDS environment, suggesting that the discordant helix plays a key role on the conformational stabilization of Abeta. Congo Red 13-15 amyloid beta precursor protein Homo sapiens 28-33 22702727-8 2012 Furthermore, CR may prevent Abeta(40) undergoing alpha-helix to beta-strand conversion, and therefore aggregation through stabilizing the helical conformation of discordant helix in SDS environment, suggesting that the discordant helix plays a key role on the conformational stabilization of Abeta. Congo Red 13-15 amyloid beta precursor protein Homo sapiens 292-297 21964250-6 2012 In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates. Congo Red 72-81 paired like homeobox 2B Homo sapiens 176-182 21964250-6 2012 In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates. Congo Red 72-81 paired like homeobox 2B Homo sapiens 198-204 21964250-6 2012 In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates. Congo Red 72-81 dopamine beta-hydroxylase Homo sapiens 237-240 21964250-6 2012 In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates. Congo Red 72-81 paired like homeobox 2B Homo sapiens 198-204 23300905-5 2012 Furthermore, in male mice we saw acceleration of Abeta plaque pathology using Congo red and 6E10 staining, which was further confirmed by ELISA measures of Abeta isoforms. Congo Red 78-87 amyloid beta (A4) precursor protein Mus musculus 49-54 22220317-8 2004 Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes. Congo Red 79-88 amyloid beta precursor protein Homo sapiens 23-28 22220319-9 2004 Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes. Congo Red 79-88 amyloid beta precursor protein Homo sapiens 23-28 22220320-8 2004 Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes. Congo Red 79-88 amyloid beta precursor protein Homo sapiens 23-28 21533606-4 2011 Vascular Abeta deposits in the brain of STZ-icv-treated rats (3 months old at the time of icv treatment) were visualized by Thioflavine-S staining, Congo red staining and Abeta immunohistochemistry. Congo Red 148-157 amyloid beta precursor protein Rattus norvegicus 9-14 21703413-6 2011 The aggregated forms of Abeta peptides were first characterized using electron microscopy, infrared spectroscopy, and Congo Red staining. Congo Red 118-127 amyloid beta precursor protein Rattus norvegicus 24-29 21468708-7 2011 The depressed surfaces of the bacteria in the MFC with EP1 indicated the allergic response caused by the subsequent addition of Congo red. Congo Red 128-137 prostaglandin E receptor 1 Homo sapiens 55-58 21504025-5 2011 TTR protofibrils obtained by mild acidification appeared as flexible filaments with variable length and were able to bind amyloid markers (thioflavin T and Congo red). Congo Red 156-165 transthyretin Homo sapiens 0-3 21543651-2 2011 Workup of the AA amyloidosis revealed chronic hepatitis B. Laser microdissection of the Congo-red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry confirmed the presence of serum amyloid A (SAA) protein and ruled out hereditary and familial amyloidosis. Congo Red 88-97 serum amyloid A1 cluster Homo sapiens 218-233 20958245-5 2010 Mid2 turned out to be the main sensor involved in the detection of damage provoked by Congo Red, whereas the transcriptional response to Caspofungin is mediated almost exclusively by Wsc1. Congo Red 86-95 Mid2p Saccharomyces cerevisiae S288C 0-4 21666345-8 2011 We screened the chemicals that improved these cellular dysfunctions and identified several compounds, including trehalose and Congo red, which could be novel therapeutics for SCA14. Congo Red 126-135 protein kinase C gamma Homo sapiens 175-180 21077638-5 2010 Our results show that CR binds to the fibril forming stretches of Abeta(1-40) monomers, and that complex formation occurs in two steps: An initial 1:1 CR:Abeta(1-40) complex is formed by a relatively strong interaction (K(d) 5 muM), and a 2:1 complex is formed by binding another CR molecule in a subsequent weaker binding step (K(d) 300 muM). Congo Red 22-24 latexin Homo sapiens 229-232 21077638-5 2010 Our results show that CR binds to the fibril forming stretches of Abeta(1-40) monomers, and that complex formation occurs in two steps: An initial 1:1 CR:Abeta(1-40) complex is formed by a relatively strong interaction (K(d) 5 muM), and a 2:1 complex is formed by binding another CR molecule in a subsequent weaker binding step (K(d) 300 muM). Congo Red 22-24 latexin Homo sapiens 342-345 21077638-5 2010 Our results show that CR binds to the fibril forming stretches of Abeta(1-40) monomers, and that complex formation occurs in two steps: An initial 1:1 CR:Abeta(1-40) complex is formed by a relatively strong interaction (K(d) 5 muM), and a 2:1 complex is formed by binding another CR molecule in a subsequent weaker binding step (K(d) 300 muM). Congo Red 151-153 latexin Homo sapiens 229-232 21077638-5 2010 Our results show that CR binds to the fibril forming stretches of Abeta(1-40) monomers, and that complex formation occurs in two steps: An initial 1:1 CR:Abeta(1-40) complex is formed by a relatively strong interaction (K(d) 5 muM), and a 2:1 complex is formed by binding another CR molecule in a subsequent weaker binding step (K(d) 300 muM). Congo Red 151-153 latexin Homo sapiens 342-345 21089051-0 2010 Detection of Abeta plaques by a novel specific MRI probe precursor CR-BSA-(Gd-DTPA)n in APP/PS1 transgenic mice. Congo Red 67-69 amyloid beta (A4) precursor protein Mus musculus 13-18 21089051-0 2010 Detection of Abeta plaques by a novel specific MRI probe precursor CR-BSA-(Gd-DTPA)n in APP/PS1 transgenic mice. Congo Red 67-69 presenilin 1 Mus musculus 92-95 21409287-7 2011 According to this information, we found that Congo Red and X-34 could strongly inhibit ApoE/Abeta interaction. Congo Red 45-54 apolipoprotein E Homo sapiens 87-91 21409287-7 2011 According to this information, we found that Congo Red and X-34 could strongly inhibit ApoE/Abeta interaction. Congo Red 45-54 amyloid beta precursor protein Homo sapiens 92-97 21695120-6 2011 Both hIAPP and hproIAPP expression caused formation of aggregates in CNS and fat body region, and these aggregates were both stained by the dyes Congo red and pFTAA, both known to detect amyloid. Congo Red 145-154 islet amyloid polypeptide Homo sapiens 5-10 21062056-7 2010 Further experiments focused on exploring the mechanism of rescue for one of these compounds: Electron microscopy and Congo red binding showed that the compound enhances fibril formation, and suggest that it may rescue cells by accelerating Abeta aggregation past an early toxic oligomer. Congo Red 117-126 amyloid beta precursor protein Rattus norvegicus 240-245 20448140-3 2010 Here, we present evidence that the (mut)CDSN deposits display an affinity for amyloidophilic dyes, namely Congo red and thioflavin T. Congo Red 106-115 corneodesmosin Homo sapiens 40-44 21046948-0 2010 Bleaching of Congo red in the presence of ZnS nanoparticles, with dopant of Co2+ ion, as photocatalyst under UV and sunlight irradiations. Congo Red 13-22 complement C2 Homo sapiens 76-79 21046948-1 2010 The bleaching of Congo red was studied in the presence of zinc sulphide nanoparticles doped with Co2+ ion. Congo Red 17-26 complement C2 Homo sapiens 97-100 20938103-0 2010 Congo red, an amyloid-inhibiting compound, alleviates various types of cellular dysfunction triggered by mutant protein kinase cgamma that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation. Congo Red 0-9 protein kinase C gamma Homo sapiens 112-133 20381118-6 2010 Histologic examination revealed a massive deposition of Congo red-positive amyloid identified as amyloid protein transthyretin by both immunohistochemistry and mass spectrometry using formalin-fixed, paraffin-embedded tissues. Congo Red 56-65 transthyretin Homo sapiens 113-126 20396423-4 2010 Biopsy of one of these nodules revealed beta2-microglobulin amyloidosis by histopathology, Congo red stain, electron microscopy, and immunohistochemistry. Congo Red 91-100 beta-2-microglobulin Homo sapiens 40-59 20111867-8 2010 Using the amyloid-specific dyes, Congo Red and Thioflavin S, we find that SOD1-positive inclusions in familial ALS, as well as TDP-43- and ubiquitin-positive inclusions in sporadic ALS, contain non-amyloid protein deposits. Congo Red 33-42 superoxide dismutase 1 Homo sapiens 74-78 20133843-7 2010 Incubation of MetO-apoA-I for extended periods resulted in aggregation of the protein, and these aggregates bound Thioflavin T and Congo Red. Congo Red 131-140 apolipoprotein A1 Homo sapiens 19-25 20938103-0 2010 Congo red, an amyloid-inhibiting compound, alleviates various types of cellular dysfunction triggered by mutant protein kinase cgamma that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation. Congo Red 0-9 protein kinase C gamma Homo sapiens 146-176 20938103-0 2010 Congo red, an amyloid-inhibiting compound, alleviates various types of cellular dysfunction triggered by mutant protein kinase cgamma that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation. Congo Red 0-9 protein kinase C gamma Homo sapiens 178-183 20938103-10 2010 These results indicate that amyloid-inhibiting compounds like Congo red may be novel therapeutics for SCA14. Congo Red 62-71 protein kinase C gamma Homo sapiens 102-107 19155189-0 2009 Spectroscopic studies on the interaction of Congo Red with bovine serum albumin. Congo Red 44-53 albumin Homo sapiens 66-79 19890987-6 2010 Here, we present a corrected formula for measuring amyloid formation of Sup35NM by Congo Red assay. Congo Red 83-92 translation termination factor GTPase eRF3 Saccharomyces cerevisiae S288C 72-77 19854225-0 2009 Fungal proteins with mannanase activity identified directly from a Congo Red stained zymogram by mass spectrometry. Congo Red 67-76 mannosidase beta Homo sapiens 21-30 19854225-1 2009 Secreted fungal proteins with mannanase activity were identified by mass spectrometry of bands excised from a Congo Red stained zymogram containing locust bean gum as substrate. Congo Red 110-119 mannosidase beta Homo sapiens 30-39 19874263-2 2009 First, in the high concentration regime (>10 micromolar), certain anionic molecules such as Congo red efficiently promote tau filament formation through a nucleation-elongation mechanism involving a dimeric nucleus and monomer-mediated elongation. Congo Red 92-101 microtubule associated protein tau Homo sapiens 122-125 19645507-0 2009 On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid. Congo Red 119-128 synuclein alpha Homo sapiens 98-113 19645507-3 2009 We present here a broad biophysical approach that enables us to characterize the mechanisms of interaction between alpha-synuclein, a protein whose aggregation is closely connected with Parkinson"s disease, and two small molecules, Congo red and Lacmoid, which inhibit its fibrillization. Congo Red 232-241 synuclein alpha Homo sapiens 115-130 19731227-2 2009 Amyloid fibrils composed of polymeric structures of the amyloid-beta (Abeta) concentrate at the center of senile plaques and accumulate in the walls of cerebral blood vessels, exhibiting extensive Congo red/thioflavin S staining. Congo Red 197-206 amyloid beta precursor protein Homo sapiens 56-68 20119496-4 2009 The agents described here are all small molecule Abeta-binding agents (SMAbetaBA"s) derivatives of Congo red. Congo Red 99-108 amyloid beta (A4) precursor protein Mus musculus 49-54 19550045-3 2009 Adopting UV spectroscopy, Congo red spectrophotometry and thioflavin T fluorimetry, we were able to quantify, in water, the very fast assembling time necessary for A beta (25-35) to form stable insoluble aggregates and their ability to seed or not seed fibril growth. Congo Red 26-35 amyloid beta precursor protein Homo sapiens 164-170 19559008-3 2009 The present manuscript describes a novel method for selective marking of Abeta(40) fibrils by non-fluorescent gamma-Fe(2)O(3) and fluorescent-magnetic gamma-Fe(2)O(3)-rhodamine or gamma-Fe(2)O(3)-Congo red nanoparticles, and the complete removal of the magnetized fibrils from the aqueous continuous phase by a magnetic field. Congo Red 196-205 amyloid beta precursor protein Homo sapiens 73-78 19602569-6 2009 We find that all 10 unique inserts cause RNase A to form amyloid-like fibrils which display characteristic yellow to apple-green Congo red birefringence when observed with cross polarizers. Congo Red 129-138 ribonuclease A family member 1, pancreatic Homo sapiens 41-48 19587281-5 2009 Cdk5-phosphorylated PrP became proteinase K resistant, formed Congo Red-positive fibrils, and formed aggregates that were immunostained with anti-PrP and anti-phospho-PrP(S43) (anti-pPrP(S43)). Congo Red 62-71 cyclin-dependent kinase 5 Mus musculus 0-4 19587281-5 2009 Cdk5-phosphorylated PrP became proteinase K resistant, formed Congo Red-positive fibrils, and formed aggregates that were immunostained with anti-PrP and anti-phospho-PrP(S43) (anti-pPrP(S43)). Congo Red 62-71 prion protein Mus musculus 20-23 19416105-0 2009 The role of the heat shock protein Hsp12p in the dynamic response of Saccharomyces cerevisiae to the addition of Congo red. Congo Red 113-122 lipid-binding protein HSP12 Saccharomyces cerevisiae S288C 35-41 19416105-7 2009 In particular, the decrease of the turgor pressure in the case of WT strain upon addition of Congo red is shown to be consistent with an upregulation of Hsp12p in the close vicinity of the plasma membrane. Congo Red 93-102 lipid-binding protein HSP12 Saccharomyces cerevisiae S288C 153-159 19155189-1 2009 The binding interaction of Congo Red (CGR) with bovine serum albumin (BSA) was investigated by spectroscopic techniques including fluorescence spectroscopy, UV-vis absorption, and circular dichroism (CD) spectroscopy under simulative physiological conditions. Congo Red 27-36 albumin Homo sapiens 55-68 18487014-2 2009 An amount of 0.2g of Ca-bentonite could remove more than 90.0% of the dye from 100mgL(-1) Congo red dye solution for the temperature range studied here. Congo Red 90-99 LLGL scribble cell polarity complex component 1 Homo sapiens 82-88 19250316-6 2009 hTTR and sbTTR formed thin, curved fibrils at low pH (pH 2-3) that bound thioflavin-T (thioflavin-T-positive) but did not stain with Congo Red (CR) (CR-negative). Congo Red 144-146 transthyretin Homo sapiens 0-4 19250316-6 2009 hTTR and sbTTR formed thin, curved fibrils at low pH (pH 2-3) that bound thioflavin-T (thioflavin-T-positive) but did not stain with Congo Red (CR) (CR-negative). Congo Red 149-151 transthyretin Homo sapiens 0-4 19250316-8 2009 CR-positive material of hTTR was found in this material, in agreement with previous results. Congo Red 0-2 transthyretin Homo sapiens 24-28 19372706-7 2009 Congo red staining of the Drosophila brain shows positive amyloid binding in the aged TTR V30M flies. Congo Red 0-9 transthyretin Mus musculus 86-89 19019446-10 2009 Patchy Congo red-positive amyloid deposits were found within the epithelium in 1 cornea, in Bowman"s layer and in the anterior stroma of all specimens also showing KE2, but not KE15, immunostaining. Congo Red 7-16 prefoldin subunit 6 Homo sapiens 164-167 19325915-4 2009 When agitated at acidic pH in the presence of low concentrations of guanidine or acetonitrile, metalated SOD1 formed fibrillar material which bound both thioflavin T and Congo red and had circular dichroism and infrared spectra characteristic of amyloid. Congo Red 170-179 superoxide dismutase 1 Homo sapiens 105-109 18339749-3 2008 We showed that the interfacial activation of PLA(2), evident after the preceding lag phase, coincides with the formation of oligomers staining with thioflavin T and subsequently with Congo red. Congo Red 183-192 phospholipase A2 group IB Homo sapiens 45-51 18606155-5 2008 Phosphorylated tau-positive dystrophic neurites were exclusively associated with Congo red-positive plaques as previously reported. Congo Red 81-90 microtubule associated protein tau Homo sapiens 15-18 18433772-3 2008 Current techniques for monitoring the kinetics of alpha-synuclein aggregation based on fluorescent dyes such as Thioflavin-T and Congo red detect only the terminal fibrillar species, are discontinuous and notoriously irreproducible. Congo Red 129-138 synuclein alpha Homo sapiens 50-65 18546893-4 2008 The S-sulfonated TTR was easily stained with congo red, whereas TTR itself was not. Congo Red 45-54 transthyretin Homo sapiens 17-20 18353662-6 2008 We used in vitro assays such as thioflavin-T binding and aggregation inhibitors like Congo red to reveal that A beta-peptide in its A beta-globulomer conformation is a structural entity which is independent from amyloid fibril formation. Congo Red 85-94 amyloid beta precursor protein Homo sapiens 110-116 18383026-7 2008 An increased unfolding, aggregation, and induction of Congo red-reactive molecular species in Cu(2+)-incubated wt-beta(2)m could be demonstrated while the refolding kinetics of dK58-beta(2)m, already slower than the wt molecule, appeared not to be further decreased by Cu(2+). Congo Red 54-63 beta-2-microglobulin Homo sapiens 114-122 18189141-2 2008 Curcumin, a constituent of the Indian spice Turmeric is structurally similar to Congo Red and has been demonstrated to bind Abeta amyloid and prevent further oligomerization of Abeta monomers onto growing amyloid beta-sheets. Congo Red 80-89 amyloid beta precursor protein Homo sapiens 124-129 18291106-2 2008 Here we show that (trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), a fluorescent Congo red derivative, labels tau inclusions in tissue sections from a mouse line transgenic for human P301S tau and in cases of familial frontotemporal dementia and sporadic Pick"s disease. Congo Red 112-121 microtubule associated protein tau Homo sapiens 141-144 18291106-0 2008 Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene]. Congo Red 59-68 microtubule associated protein tau Homo sapiens 25-28 18291106-2 2008 Here we show that (trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), a fluorescent Congo red derivative, labels tau inclusions in tissue sections from a mouse line transgenic for human P301S tau and in cases of familial frontotemporal dementia and sporadic Pick"s disease. Congo Red 112-121 microtubule associated protein tau Homo sapiens 220-223 17953662-0 2008 Congo red and thioflavin-T analogs detect Abeta oligomers. Congo Red 0-9 amyloid beta precursor protein Homo sapiens 42-47 17986446-4 2008 Disruption of the UBP3 gene leads to an enhanced activation of the cell wall integrity pathway MAPK Slt2 when cells are challenged with a variety of pathway activation agents such as pheromone and Congo red. Congo Red 197-206 mRNA-binding ubiquitin-specific protease UBP3 Saccharomyces cerevisiae S288C 18-22 17968688-5 2007 Endomyocardial biopsy in 2006 revealed transthyretin amyloidosis by Congo red and immunohistochemical staining, as well as Val94Ala substitution by transthyretin gene analysis. Congo Red 68-77 transthyretin Homo sapiens 39-52 17920002-5 2007 The ThT and CR binding assay revealed sigmoidal kinetics, and the spectrum of binding CR showed a red shift against time, suggesting an orderly formation of insulin aggregates. Congo Red 86-88 insulin Homo sapiens 157-164 20641418-15 2004 One promising approach of developing optical imaging probes is based on the development of small-molecules of Abeta-staining compounds, such as Congo red and thioflavin T. Congo Red 144-153 amyloid beta precursor protein Homo sapiens 110-115 17855342-6 2007 The use of a conformation-dependent antibody that recognizes only the oligomeric precursors to amyloid, negative stain electron microscopy, and Congo Red staining showed that CRES adopted similar oligomeric and fibrillar structures during its aggregation as other amyloidogenic proteins, suggesting that CRES has the potential to form amyloid in the epididymal lumen. Congo Red 144-153 cystatin 8 (cystatin-related epididymal spermatogenic) Mus musculus 175-179 17662957-6 2007 Solid-state NMR results suggest that membrane fragmentation is related to peptide aggregation as the presence of Congo Red, an inhibitor of amyloid formation, prevented membrane fragmentation and the non-amyloidogenic rat-IAPP did not cause membrane fragmentation. Congo Red 113-122 islet amyloid polypeptide Rattus norvegicus 222-226 18026214-0 2007 Modulation of Congo-red-induced aberrations in the yeast Saccharomyces cerevisiae by the general stress response protein Hsp12p. Congo Red 14-23 lipid-binding protein HSP12 Saccharomyces cerevisiae S288C 121-127 18026214-1 2007 Previous studies have shown that in Saccharomyces cerevisiae HSP12, which codes for the small cell wall heat shock protein Hsp12p, was induced upon exposure to cell-wall-damaging agents such as Congo red. Congo Red 194-203 lipid-binding protein HSP12 Saccharomyces cerevisiae S288C 61-66 18026214-1 2007 Previous studies have shown that in Saccharomyces cerevisiae HSP12, which codes for the small cell wall heat shock protein Hsp12p, was induced upon exposure to cell-wall-damaging agents such as Congo red. Congo Red 194-203 lipid-binding protein HSP12 Saccharomyces cerevisiae S288C 123-129 18026214-2 2007 Here, we demonstrate that Hsp12p decreases the interaction between Congo red and chitin. Congo Red 67-76 lipid-binding protein HSP12 Saccharomyces cerevisiae S288C 26-32 18026214-4 2007 The presence of Hsp12p was also necessary for the Congo-red-mediated invasion of agar plates. Congo Red 50-59 lipid-binding protein HSP12 Saccharomyces cerevisiae S288C 16-22 18057560-8 2007 We examined the effect of Congo red and Thioflavin T (potent fAbeta-binding compounds) on the binding of different proteases to fAbeta. Congo Red 26-35 FA complementation group A Homo sapiens 128-134 18057560-9 2007 While Congo red inhibited the binding of trypsin, neprilysin and insulysin to fAbeta, Thioflavin T did not have any effect. Congo Red 6-15 membrane metalloendopeptidase Homo sapiens 50-60 18057560-9 2007 While Congo red inhibited the binding of trypsin, neprilysin and insulysin to fAbeta, Thioflavin T did not have any effect. Congo Red 6-15 insulin degrading enzyme Homo sapiens 65-74 18057560-9 2007 While Congo red inhibited the binding of trypsin, neprilysin and insulysin to fAbeta, Thioflavin T did not have any effect. Congo Red 6-15 FA complementation group A Homo sapiens 78-84 18057560-10 2007 The effect of Congo red was concentration-dependent and the inhibitory effect was in the order of trypsin > insulysin > neprilysin. Congo Red 14-23 insulin degrading enzyme Homo sapiens 108-117 18057560-10 2007 The effect of Congo red was concentration-dependent and the inhibitory effect was in the order of trypsin > insulysin > neprilysin. Congo Red 14-23 membrane metalloendopeptidase Homo sapiens 120-130 18057560-11 2007 When the effect of prebound-Congo red to fAbeta was examined, trypsin was unable to bind to this complex suggesting that Congo red may have better affinity than trypsin for binding to fAbeta. Congo Red 121-130 FA complementation group A Homo sapiens 184-190 17597153-10 2007 Our system using NGF-differentiated PC12 cells and Congo red is useful for screening inhibitors of the formation of amyloids by and cytotoxicity of Abeta. Congo Red 51-60 amyloid beta precursor protein Rattus norvegicus 148-153 18320103-5 2007 MATERIALS AND METHODS: Levels of systemic amyloid-beta were measured with congo red staining and immuno-histochemistry of the tissues of affected cadavers, compared with non-affected cadavers. Congo Red 74-83 amyloid beta precursor protein Homo sapiens 42-54 18069327-0 2007 [Application of the complex of DNA with the congo red anionic diazo dye for detection of nuclease-producing colonies of marine bacteria]. Congo Red 44-53 nuclease Escherichia coli 89-97 18069327-10 2007 The halos were shown to result from the coagulation of CR released after digestion of the CR-DNA complex by the nuclease. Congo Red 55-57 nuclease Escherichia coli 112-120 17597153-4 2007 Here, the interaction of native Abeta-(1-42) with unfixed rat pheochromocytoma PC12 cells was visualized using the amyloid-specific dye Congo red. Congo Red 136-145 amyloid beta precursor protein Rattus norvegicus 32-37 17428800-4 2007 To overcome this limitation, a small-molecule agonist of the tau aggregation reaction, Congo red, was used to drive aggregation within HEK-293 cells expressing full-length tau isoform htau40. Congo Red 87-96 microtubule associated protein tau Homo sapiens 61-64 17428800-4 2007 To overcome this limitation, a small-molecule agonist of the tau aggregation reaction, Congo red, was used to drive aggregation within HEK-293 cells expressing full-length tau isoform htau40. Congo Red 87-96 microtubule associated protein tau Homo sapiens 172-175 17213653-1 2007 Overproduction of the ER membrane protein Rcr1 makes Saccharomyces cerevisiae resistant to Congo red by reducing the chitin content through a unknown mechanism. Congo Red 91-100 Rcr1p Saccharomyces cerevisiae S288C 42-46 17241479-6 2007 Further experiments showed that Congo Red specifically attenuated the caspase-3 activity induced by amyloid-like deposits of tau. Congo Red 32-41 caspase 3 Homo sapiens 70-79 16823041-5 2006 In addition, hARD1 forms protofilaments under physiological conditions of pH and temperature, as judged by electron microscopy and staining with the dyes Congo red and thioflavin T. Congo Red 154-163 N-alpha-acetyltransferase 10, NatA catalytic subunit Homo sapiens 13-18 16890957-2 2006 Here, we show at physiological salt concentrations and pH that native tetramers of apoE form soluble aggregates in vitro that bind the amyloid dyes thioflavin T and Congo red. Congo Red 165-174 apolipoprotein E Homo sapiens 83-87 17027170-7 2006 In the Tg2576 mice MT-I was weakly upregulated in cells surrounding Congo Red-positive plaques in the cortex and hippocampus. Congo Red 68-77 metallothionein 1 Mus musculus 19-23 17234824-3 2006 To address the molecular mechanisms of dementia and delirium associated with anesthesia and surgery, we assessed whether the Abeta fibrillar aggregation inhibitor Congo red can attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells overexpressing human beta-amyloid precursor protein (APP). Congo Red 163-172 caspase 3 Homo sapiens 206-215 17234824-3 2006 To address the molecular mechanisms of dementia and delirium associated with anesthesia and surgery, we assessed whether the Abeta fibrillar aggregation inhibitor Congo red can attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells overexpressing human beta-amyloid precursor protein (APP). Congo Red 163-172 amyloid beta precursor protein Homo sapiens 278-308 16920040-6 2006 The heat-induced irreversible aggregates of ESA are composed of the intermolecular beta-sheet structure without binding thioflavie T and Congo red to be amorphous form. Congo Red 137-146 paraoxonase 1 Homo sapiens 44-47 16565748-1 2006 The ability of Congo red to form complexes with alpha-proteins, human growth hormone and human interferon-alpha2b, was found by absorption difference spectroscopy. Congo Red 15-24 growth hormone 1 Homo sapiens 70-84 16681381-3 2006 Several polyphenols, phenothiazines, porphyrins, polyene macrolides, and Congo red and its derivatives, BSB and FSB, inhibited alpha-synuclein filament assembly with IC(50) values in the low micromolar range. Congo Red 73-82 synuclein alpha Homo sapiens 127-142 16441845-4 2006 We observed saturable binding of [(125)I]CQ to synthetic Abeta precipitated by Zn(2+) (K(d)=0.45 and 1.40 nm for Abeta(1-42) and Abeta(1-40), respectively), which was fully displaced by free Zn(2+), Cu(2+), the chelator DTPA (diethylene triamine pentaacetic acid) and partially by Congo red. Congo Red 281-290 amyloid beta (A4) precursor protein Mus musculus 57-62 16707786-5 2006 Both groups receiving anti-Abeta antibodies showed significant reductions in total Abeta immunochemistry and Congo red. Congo Red 109-118 amyloid beta (A4) precursor protein Mus musculus 27-32 16467475-6 2006 Finally, we report that Hog1 represses the activation of the Cek1 MAP kinase under basal conditions and that Cek1 activation correlates with resistance to certain cell wall inhibitors (such as Congo red), demonstrating a role for this pathway in cell wall biogenesis. Congo Red 193-202 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 24-28 16565748-1 2006 The ability of Congo red to form complexes with alpha-proteins, human growth hormone and human interferon-alpha2b, was found by absorption difference spectroscopy. Congo Red 15-24 interferon alpha 2 Homo sapiens 95-113 16565748-2 2006 A human growth hormone-Congo red complex was isolated by gel-permeation chromatography, and its visible absorption spectrum was registered in comparison to free dye. Congo Red 23-32 growth hormone 1 Homo sapiens 8-22 16565748-3 2006 The ability of Congo red to induce dimerization of human growth hormone was demonstrated using chemical cross-linking agents 1,3,5-triacryloyl-hexahydro-s-triazine and ethylene glycol bis(succinimidylsuccinate). Congo Red 15-24 growth hormone 1 Homo sapiens 57-71 16286092-5 2005 The fibrillar structures formed by MIF bind Congo red and exhibit the characteristic green birefringence under polarized light. Congo Red 44-53 macrophage migration inhibitory factor Homo sapiens 35-38 17406451-2 2006 Congo red staining detects amyloid deposits in brain tissue of amyloid precursor protein transgenic mice and human Alzheimer"s tissue. Congo Red 0-9 amyloid beta (A4) precursor protein Mus musculus 63-88 17684540-3 2006 Results (1) The PS1/APP transgenic mouse extensively displayed Abeta deposits in the cortex and hippocampal structures, and GFAP positive cells were aggregated in mass and surrounded the congo red-positive plaque. Congo Red 187-196 glial fibrillary acidic protein Mus musculus 124-128 17046656-4 2006 Amyloid-beta peptide (Abeta) of extracellular senile plaques (SP) and hyperphosphorylated tau of intracellular neurofibrillary tangles (NFT) are assembled in the abnormal beta-pleated sheet (amyloid-like) structural conformation that can be visualized with histological staining procedures using Congo red or its derivatives. Congo Red 296-305 microtubule associated protein tau Homo sapiens 90-93 15994066-4 2005 Using ThT-induced fluorescence, turbidity, Congo red binding, and circular dichroism spectroscopy studies, our research demonstrated that the inhibition of A beta(1--40) fibril formation was di-C6-PC and di-C7-PC concentration-dependent. Congo Red 43-52 amyloid beta precursor protein Homo sapiens 156-162 16169977-1 2005 In 5% (v/v) trifluoroethanol, pH 5.5, 25 degrees C one of the acylphosphatases from Drosophila melanogaster (AcPDro2) forms fibrillar aggregates that bind thioflavin T and Congo red and have an extensive beta-sheet structure, as revealed by circular dichroism. Congo Red 172-181 Acylphosphatase 2 Drosophila melanogaster 109-116 16054644-3 2005 When incubated for several weeks at neutral pH in the presence of the denaturant guanidine hydrochloride, GroES formed a typical amyloid fibril; unbranched, twisted, and extended filaments stainable by thioflavin T and Congo red. Congo Red 219-228 chaperonin GroES Escherichia coli 106-111 15855161-2 2005 Each of the main compound classes, derived from thioflavin T (PIB), Congo Red (BSB), and aminonaphthalene (FDDNP) are believed to bind to mutually exclusive sites on the beta-amyloid (Abeta) peptide fibrils. Congo Red 68-77 amyloid beta precursor protein Homo sapiens 184-189 16042540-5 2005 Inspired by strategies used in Nature and optimized over millions of years of evolution, we have created a bifunctional molecule [SLF (synthetic ligand for FK506-binding protein)-CR (Congo Red)] that is able to block Abeta (amyloid beta) aggregation by borrowing the surface and steric bulk of a cellular chaperone. Congo Red 183-192 amyloid beta precursor protein Homo sapiens 217-222 16042540-5 2005 Inspired by strategies used in Nature and optimized over millions of years of evolution, we have created a bifunctional molecule [SLF (synthetic ligand for FK506-binding protein)-CR (Congo Red)] that is able to block Abeta (amyloid beta) aggregation by borrowing the surface and steric bulk of a cellular chaperone. Congo Red 183-192 amyloid beta precursor protein Homo sapiens 224-236 15974895-0 2005 Acetylcholinesterase-amyloid-beta-peptide interaction: effect of Congo Red and the role of the Wnt pathway. Congo Red 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15974895-7 2005 Congo Red dye stabilizes the Abeta monomer, is able to inhibit oligomerization, and inhibits the binding of AChE to Abeta. Congo Red 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 15974895-10 2005 Docking studies were performed to evaluate the binding of Congo Red to Abeta in order to identify putative binding sites in the Abeta monomer that might interact with AChE. Congo Red 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 16000714-8 2005 Here, using the tailored microarray, the role of the HOG1 pathway in the regulation of the transcriptional compensatory response to cell wall damage was evaluated by comparing the transcriptional profiles of a hog1 mutant and a wild-type strain in the presence of Congo red. Congo Red 264-273 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 53-57 16000714-8 2005 Here, using the tailored microarray, the role of the HOG1 pathway in the regulation of the transcriptional compensatory response to cell wall damage was evaluated by comparing the transcriptional profiles of a hog1 mutant and a wild-type strain in the presence of Congo red. Congo Red 264-273 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 210-214 16170462-8 2005 BSB, a Congo red derivative that binds to amyloid fibrils in FAP as well as to those in senile plaques in Alzheimer"s disease, effectively suppressed TTR amyloid formation in vitro. Congo Red 7-16 transthyretin Homo sapiens 150-153 15974928-6 2005 Congo red is a chemically synthesized small molecule that has binding affinity to Abeta. Congo Red 0-9 histocompatibility 2, class II antigen A, beta 1 Mus musculus 82-87 15778960-1 2005 It was shown experimentally that binding of a micelle composed of Congo red molecules to immunological complexes leads to the enhanced stability of the latter, and simultaneously prevents binding of a complement molecule (C1q). Congo Red 66-75 complement C1q A chain Homo sapiens 222-225 15974928-7 2005 In the present study, we tested three Congo red derivatives in Abeta plaque-forming mice at an early pathological stage. Congo Red 38-47 histocompatibility 2, class II antigen A, beta 1 Mus musculus 63-68 15576361-2 2005 We showed that equine lysozyme assembles into soluble amyloid oligomers and protofilaments at pH 2.0 and 4.5, 57 degrees C. They bind thioflavin-T and Congo red similar to common amyloid structures, and their morphology was monitored by atomic force microscopy. Congo Red 151-160 lysozyme Equus caballus 22-30 15766269-5 2005 The unfolding rate is 1 order of magnitude faster in DeltaK58-beta(2)m than in wt-beta(2)m, and at 37 degrees C the half-time for unfolding is more than 170-fold faster than at 15 degrees C. Conformational changes are also reflected by a very prominent Congo red binding of DeltaK58-beta(2)m at 37 degrees C, by the evolution of thioflavin T fluorescence, and by changes in intrinsic fluorescence. Congo Red 253-262 beta-2-microglobulin Homo sapiens 62-70 15766269-5 2005 The unfolding rate is 1 order of magnitude faster in DeltaK58-beta(2)m than in wt-beta(2)m, and at 37 degrees C the half-time for unfolding is more than 170-fold faster than at 15 degrees C. Conformational changes are also reflected by a very prominent Congo red binding of DeltaK58-beta(2)m at 37 degrees C, by the evolution of thioflavin T fluorescence, and by changes in intrinsic fluorescence. Congo Red 253-262 beta-2-microglobulin Homo sapiens 82-90 15766269-5 2005 The unfolding rate is 1 order of magnitude faster in DeltaK58-beta(2)m than in wt-beta(2)m, and at 37 degrees C the half-time for unfolding is more than 170-fold faster than at 15 degrees C. Conformational changes are also reflected by a very prominent Congo red binding of DeltaK58-beta(2)m at 37 degrees C, by the evolution of thioflavin T fluorescence, and by changes in intrinsic fluorescence. Congo Red 253-262 beta-2-microglobulin Homo sapiens 82-90 15751948-5 2005 This simple, rapid, and novel methodology was applied here to two amyloidogenic proteins, insulin and lysozyme, and its validity for detection of their fibrillar conformation was verified by currently used methods such as circular dichroism, transmission electron microscopy, and Congo red absorption. Congo Red 280-289 insulin Homo sapiens 90-97 15723529-9 2005 Intriguingly, the association of endostatin with PS-containing liposomes triggered the formation of fibers, with Congo red staining producing green birefringence characteristic for amyloid. Congo Red 113-122 collagen type XVIII alpha 1 chain Homo sapiens 33-43 15722443-4 2005 We then examined the ability of Hsp20 produced as two different fusion proteins to prevent Abeta amyloid formation as indicated by Congo Red binding; we found that not only was Hsp20 able to dramatically reduce Congo Red binding, but it was able to do so at molar ratios of Hsp20 to Abeta of 1 to 1000. Congo Red 131-140 heat shock protein family B (small) member 6 Rattus norvegicus 32-37 15722443-4 2005 We then examined the ability of Hsp20 produced as two different fusion proteins to prevent Abeta amyloid formation as indicated by Congo Red binding; we found that not only was Hsp20 able to dramatically reduce Congo Red binding, but it was able to do so at molar ratios of Hsp20 to Abeta of 1 to 1000. Congo Red 131-140 amyloid beta precursor protein Homo sapiens 91-96 15722443-4 2005 We then examined the ability of Hsp20 produced as two different fusion proteins to prevent Abeta amyloid formation as indicated by Congo Red binding; we found that not only was Hsp20 able to dramatically reduce Congo Red binding, but it was able to do so at molar ratios of Hsp20 to Abeta of 1 to 1000. Congo Red 211-220 heat shock protein family B (small) member 6 Rattus norvegicus 32-37 15722443-4 2005 We then examined the ability of Hsp20 produced as two different fusion proteins to prevent Abeta amyloid formation as indicated by Congo Red binding; we found that not only was Hsp20 able to dramatically reduce Congo Red binding, but it was able to do so at molar ratios of Hsp20 to Abeta of 1 to 1000. Congo Red 211-220 amyloid beta precursor protein Homo sapiens 91-96 15722443-4 2005 We then examined the ability of Hsp20 produced as two different fusion proteins to prevent Abeta amyloid formation as indicated by Congo Red binding; we found that not only was Hsp20 able to dramatically reduce Congo Red binding, but it was able to do so at molar ratios of Hsp20 to Abeta of 1 to 1000. Congo Red 211-220 heat shock protein family B (small) member 6 Rattus norvegicus 177-182 15722443-4 2005 We then examined the ability of Hsp20 produced as two different fusion proteins to prevent Abeta amyloid formation as indicated by Congo Red binding; we found that not only was Hsp20 able to dramatically reduce Congo Red binding, but it was able to do so at molar ratios of Hsp20 to Abeta of 1 to 1000. Congo Red 211-220 heat shock protein family B (small) member 6 Rattus norvegicus 177-182 15722443-4 2005 We then examined the ability of Hsp20 produced as two different fusion proteins to prevent Abeta amyloid formation as indicated by Congo Red binding; we found that not only was Hsp20 able to dramatically reduce Congo Red binding, but it was able to do so at molar ratios of Hsp20 to Abeta of 1 to 1000. Congo Red 211-220 amyloid beta precursor protein Homo sapiens 283-288 15780472-5 2005 The fly phenotype is rescued by treatment with Congo Red that reduces Abeta aggregation in vitro. Congo Red 47-56 beta amyloid protein precursor-like Drosophila melanogaster 70-75 15709490-3 2005 The phosphorylated Abeta peptide showed increased neurotoxicity and reduced ability to form Congo red-positive fibrils. Congo Red 92-101 amyloid beta precursor protein Homo sapiens 19-24 15709480-2 2005 Spectroscopic UV/V is measurements for the pH- and time-dependence binding of CR to Abeta analogues are analysed by Scatchard binding and the theory of nucleation-dependent fibril formation. Congo Red 78-80 amyloid beta precursor protein Homo sapiens 84-89 15709480-4 2005 As revealed by atomic models of the Abeta protofilament, such as the nanotube beta-helix and parallel beta-sheet, the regular arrangement of histidines likely acts as a template for the end-to-end J-aggregation of CR molecules, which produces a red shift in UV/V is absorption. Congo Red 214-216 amyloid beta precursor protein Homo sapiens 36-41 15530469-6 2004 The formation of fibrillar Abeta(25-35) in the presence of transferrin was investigated using Congo red staining and spectrophotometric studies. Congo Red 94-103 transferrin Homo sapiens 59-70 15478464-8 2004 The results showed a significant positive correlation between age and amyloid quantity (Congo red staining), HNE staining and lipofuscin (LF), and between amyloid quantity and HNE staining and LF. Congo Red 88-97 renin binding protein Canis lupus familiaris 62-65 15481988-2 2004 In this paper, we describe the synthesis of analogues of Congo red and evaluation against a cellular model of infection, the SMB (scrapie mouse brain) persistently infected cell line, for their ability to inhibit the infectivity of the abnormal form of prion protein (PrP-res). Congo Red 57-66 prion protein Homo sapiens 268-271 15161650-4 2004 In fact, AChE strongly stimulates rat Abeta aggregation in vitro as shown by turbidity measurements, Congo Red binding, as well as electron microscopy, suggesting that Abeta-AChE deposits observed in vivo probably recruited endogenous Abeta peptide; 2). Congo Red 101-110 acetylcholinesterase Rattus norvegicus 9-13 15161650-4 2004 In fact, AChE strongly stimulates rat Abeta aggregation in vitro as shown by turbidity measurements, Congo Red binding, as well as electron microscopy, suggesting that Abeta-AChE deposits observed in vivo probably recruited endogenous Abeta peptide; 2). Congo Red 101-110 acetylcholinesterase Rattus norvegicus 174-178 15147317-5 2004 Fibrillar material, as determined by electron microscopy, was obvious in all these peptide solutions and exhibited appreciable Congo Red binding, particularly for A beta(1-40)G22 and A beta(1-40)Q22. Congo Red 127-136 amyloid beta precursor protein Rattus norvegicus 163-169 15014955-5 2004 On the other hand, activated microglia and reactive astrocytes associated with fibrillar (Congo red-positive) Abeta deposition, i.e., Abeta42(+)40(+) dense diffuse plaques and CAA invading the parenchyma, were virtually devoid of Abeta granules. Congo Red 90-99 amyloid beta precursor protein Homo sapiens 110-115 15014955-5 2004 On the other hand, activated microglia and reactive astrocytes associated with fibrillar (Congo red-positive) Abeta deposition, i.e., Abeta42(+)40(+) dense diffuse plaques and CAA invading the parenchyma, were virtually devoid of Abeta granules. Congo Red 90-99 amyloid beta precursor protein Homo sapiens 134-139 15147317-5 2004 Fibrillar material, as determined by electron microscopy, was obvious in all these peptide solutions and exhibited appreciable Congo Red binding, particularly for A beta(1-40)G22 and A beta(1-40)Q22. Congo Red 127-136 amyloid beta precursor protein Rattus norvegicus 183-189 15094456-4 2004 TRAIL-like immunoreactivity was localized in AD affected regions, such as cerebral cortex, often in the proximity of Congo-red-positive amyloid plaques. Congo Red 117-126 TNF superfamily member 10 Homo sapiens 0-5 14570591-2 2004 Yeast cells with the Hsp 12 gene disrupted were unable to grow in the presence of either 12 mM caffeine or 0.43 mM Congo Red, molecules known to affect cell-wall integrity. Congo Red 115-124 lipid-binding protein HSP12 Saccharomyces cerevisiae S288C 21-27 14703512-3 2004 Consistent with a role of this phosphatase on cell wall physiology, cells lacking Msg5 displayed an increased sensitivity to the cell wall-interfering compound Congo Red. Congo Red 160-169 tyrosine/serine/threonine protein phosphatase MSG5 Saccharomyces cerevisiae S288C 82-86 14661975-11 2003 In contrast, human Q36 ataxin-3 underwent a progressive increase in the beta-sheet and a concomitant decrease in helical content when the temperature was shifted from 37 to 80 degrees C, followed by the irreversible formation of aggregates above 80 degrees C. They were shown to consist of amyloid fibrils, as supported by both electron microscopy images and the typical spectral shift displayed by Congo red when it was added to the protein at growing temperatures. Congo Red 399-408 ataxin 3 Homo sapiens 23-31 14720210-4 2004 Induction of calsenilin was also observed in the activated astroglia as well as in the neurons surrounding beta-amyloid (Abeta)- and Congo red-positive plaques. Congo Red 133-142 Kv channel interacting protein 3, calsenilin Mus musculus 13-23 14583196-5 2003 As seen with other amyloid proteins, the ABri fibrils had characteristic binding with Congo red and thioflavin-T, and the relative amounts of beta-sheet and amyloid fibril-like structures are influenced strongly by pH. Congo Red 86-95 integral membrane protein 2B Homo sapiens 41-45 12941771-7 2003 Amyloid staining by Congo red fluorescence was detectable at 100 nmol/l amylin and was pronounced at 1,000 nmol/l amylin treatment for 48 h. Bacitracin treatment markedly increased staining at all amylin concentrations. Congo Red 20-29 islet amyloid polypeptide Homo sapiens 72-78 15115956-8 2003 All of the patients presented with deposits of amyloid substance in the lymph nodes and the nerves of the hepatic hilium These deposits were Congo red positive with a greenish birefringence to polarized light Deposits show immunoreactivity with antihuman TTR. Congo Red 141-150 transthyretin Homo sapiens 255-258 12812521-4 2003 Of the compounds investigated, incubation of human amylin with a 20-fold molar excess of either Congo Red or Acridine Orange resulted in significant inhibition in the rate of amyloid formation. Congo Red 96-105 islet amyloid polypeptide Homo sapiens 51-57 12812521-5 2003 With Congo Red, maximal inhibition effectively occurred at a 1:1 molar ratio or greater over human amylin, whereas inhibition by Acridine Orange was dose-dependent. Congo Red 5-14 islet amyloid polypeptide Homo sapiens 99-105 12746917-12 2003 Coincident with SAA binding, precipitates developed an affinity for Congo red. Congo Red 68-77 serum amyloid A cluster Mus musculus 16-19 14640043-9 2003 (Trans, trans)-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), a Congo red derivative that binds to amyloid fibrils in FAP, as well as to those in senile plaques in Alzheimer"s disease, effectively suppressed TTR amyloid formation in vitro. Congo Red 81-90 transthyretin Homo sapiens 225-228 13679188-3 2003 The discovery that the sulphonated azo dye Congo red (CR) is able to inhibit the replications of TSE agents and the accumulation of PrP(res) in animals and in scrapie infected mouse neuroblastoma cells induced us to designe molecules structurally related to CR (1a-f, 2f,g). Congo Red 43-52 prion protein Mus musculus 132-135 13679188-3 2003 The discovery that the sulphonated azo dye Congo red (CR) is able to inhibit the replications of TSE agents and the accumulation of PrP(res) in animals and in scrapie infected mouse neuroblastoma cells induced us to designe molecules structurally related to CR (1a-f, 2f,g). Congo Red 54-56 prion protein Mus musculus 132-135 14706557-4 2003 Here, NAP was shown to inhibit Abeta aggregation using: (1) fluorimetry; (2) electron microscopy; (3) high-throughput screening of Abeta deposition onto a synthetic template (synthaloid); and (4) Congo Red staining of neurons. Congo Red 196-205 amyloid beta precursor protein Homo sapiens 31-36 12746917-13 2003 Over time, as more SAA was added, networks of Congo red-positive material producing bright green birefringence also developed outward from AEF precipitates. Congo Red 46-55 serum amyloid A cluster Mus musculus 19-22 12655105-7 2003 To validate its use in this assay, this bacterial recombinant PrP has been shown to have the conversion properties of mammalian PrP(C): (i) it converts to a proteinase K-resistant isoform in the presence of PrP(Sc); (ii) the efficiency of this conversion by PrP(Sc) of different strains and species parallels that found in vivo; and (iii) its cell-free conversion is inhibited by Congo Red analogues in a structure-dependent manner similar to that seen in in vivo and in vitro cell assays. Congo Red 380-389 prion protein Homo sapiens 62-65 12655105-7 2003 To validate its use in this assay, this bacterial recombinant PrP has been shown to have the conversion properties of mammalian PrP(C): (i) it converts to a proteinase K-resistant isoform in the presence of PrP(Sc); (ii) the efficiency of this conversion by PrP(Sc) of different strains and species parallels that found in vivo; and (iii) its cell-free conversion is inhibited by Congo Red analogues in a structure-dependent manner similar to that seen in in vivo and in vitro cell assays. Congo Red 380-389 prion protein Homo sapiens 128-131 12655105-7 2003 To validate its use in this assay, this bacterial recombinant PrP has been shown to have the conversion properties of mammalian PrP(C): (i) it converts to a proteinase K-resistant isoform in the presence of PrP(Sc); (ii) the efficiency of this conversion by PrP(Sc) of different strains and species parallels that found in vivo; and (iii) its cell-free conversion is inhibited by Congo Red analogues in a structure-dependent manner similar to that seen in in vivo and in vitro cell assays. Congo Red 380-389 prion protein Homo sapiens 128-131 12655105-7 2003 To validate its use in this assay, this bacterial recombinant PrP has been shown to have the conversion properties of mammalian PrP(C): (i) it converts to a proteinase K-resistant isoform in the presence of PrP(Sc); (ii) the efficiency of this conversion by PrP(Sc) of different strains and species parallels that found in vivo; and (iii) its cell-free conversion is inhibited by Congo Red analogues in a structure-dependent manner similar to that seen in in vivo and in vitro cell assays. Congo Red 380-389 prion protein Homo sapiens 128-131 12171927-4 2002 Furthermore, Congo Red, a dye that stains amyloid fibrils, prevented the assembly of mutant htt into mature fibrils, but not the formation of protofibrils. Congo Red 13-22 huntingtin Homo sapiens 92-95 12634062-2 2003 Circular dichroism, Fourier transform infrared spectroscopy and staining with Congo red and thioflavin T showed that p53tet-wt and p53tet-R337H adopt an alternative beta-sheet conformation (p53tet-wt-beta and p53tet-R337H-beta, respectively), characteristic of amyloid-like fibrils, when incubated at pH 4.0 and elevated temperatures. Congo Red 78-87 tumor protein p53 Homo sapiens 117-120 12634062-2 2003 Circular dichroism, Fourier transform infrared spectroscopy and staining with Congo red and thioflavin T showed that p53tet-wt and p53tet-R337H adopt an alternative beta-sheet conformation (p53tet-wt-beta and p53tet-R337H-beta, respectively), characteristic of amyloid-like fibrils, when incubated at pH 4.0 and elevated temperatures. Congo Red 78-87 tumor protein p53 Homo sapiens 131-134 12605343-6 2003 Using circular dichroism and Congo red absorption techniques we found that clinically relevant doses of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDS) prevented and also reversed the beta-sheet conformation of human amylin. Congo Red 29-38 islet amyloid polypeptide Homo sapiens 233-239 12615539-2 2003 It is believed that assembly of intact Ure2p into fibrillar polymers that bind Congo Red and show yellow-green birefringence upon staining and are resistant to proteolysis is the consequence of a major change in the conformation of the protein. Congo Red 79-88 glutathione peroxidase Saccharomyces cerevisiae S288C 39-44 12615539-3 2003 We recently dissected the assembly process of Ure2p and showed the protein to retain its native alpha-helical structure upon assembly into protein fibrils that are similar to amyloids in that they are straight, bind Congo red and show green-yellow birefringence and have an increased resistance to proteolysis (). Congo Red 216-225 glutathione peroxidase Saccharomyces cerevisiae S288C 46-51 12557756-2 2002 Congo red staining of vitrectomy specimens revealed that the vitreous fluid contained amyloid fibrils, which were strongly positive for immunohistochemical staining using anti-human TTR antiserum. Congo Red 0-9 transthyretin Homo sapiens 182-185 13678330-3 2003 In this study, Congo red was used to observe the binding accessibility of (1) monocytes (human) induced by contact with cancer cells (HCV29T, human), (2) monocytes (mouse) stimulated by interaction with heat-aggregated IgG and (3) monocytes (mouse) activated by rosetting in the presence of an SRBC-anti-SRBC system. Congo Red 15-24 immunoglobulin heavy chain (V7183 family) Mus musculus 219-222 12587666-1 2003 Human C1q when injected directly into hippocampus and cortex of doubly transgenic APP+PS1 mice results in the increase of Congo red-positive fibrillar deposits. Congo Red 122-131 complement component 1, q subcomponent, alpha polypeptide Mus musculus 6-9 12587666-1 2003 Human C1q when injected directly into hippocampus and cortex of doubly transgenic APP+PS1 mice results in the increase of Congo red-positive fibrillar deposits. Congo Red 122-131 amyloid beta (A4) precursor protein Mus musculus 82-89 12438944-3 2002 This report demonstrates that albumin, another serum component, is 8-fold more protective: a concentration of 12.5 microg/ml protects RBCs against 20 microM-Abeta25-35, and prevents the formation of fibrillar Abeta25-35 aggregates stainable by Congo Red. Congo Red 244-253 albumin Homo sapiens 30-37 12377930-5 2002 Persistent exposure of FPRL1-expressing cells to Abeta(42) resulted in intracellular retention of Abeta(42)/FPRL1 complexes and the formation of Congo-red-positive fibrils in mononuclear phagocytes. Congo Red 145-154 formyl peptide receptor 2 Homo sapiens 23-28 12377930-5 2002 Persistent exposure of FPRL1-expressing cells to Abeta(42) resulted in intracellular retention of Abeta(42)/FPRL1 complexes and the formation of Congo-red-positive fibrils in mononuclear phagocytes. Congo Red 145-154 amyloid beta precursor protein Homo sapiens 49-54 11801591-7 2002 In the cleaved and trimmed beta(2)-microglobulin that appears in vivo, the less populated conformation is characterized by an increased affinity for Congo red. Congo Red 149-158 beta-2-microglobulin Homo sapiens 27-48 12440482-3 2002 Lysis resulted from poreformation in the RBC membranes and was completely prevented by concurrent exposure to Congo red We demonstrate that human serum, purified ApoE from human plasma, and recombinant isoforms of ApoE neutralize the Abeta(25-35) cytotoxicity: the E2 and E4 isoforms were marginally more effective than E3. Congo Red 110-119 apolipoprotein E Homo sapiens 162-166 12440482-3 2002 Lysis resulted from poreformation in the RBC membranes and was completely prevented by concurrent exposure to Congo red We demonstrate that human serum, purified ApoE from human plasma, and recombinant isoforms of ApoE neutralize the Abeta(25-35) cytotoxicity: the E2 and E4 isoforms were marginally more effective than E3. Congo Red 110-119 apolipoprotein E Homo sapiens 214-218 11846043-3 2002 These Abeta-deposits can be visualized by thioflavin S, Congo red staining, silver staining methods and immunohistochemistry. Congo Red 56-65 amyloid beta precursor protein Homo sapiens 6-11 11870762-8 2002 The whole-column imaging CE with the short capillary has been applied for the study of conjugation reactions of protein cytochrome c with sodium dodecyl sulfate (SDS) and the dye Congo Red. Congo Red 179-188 cytochrome c, somatic Homo sapiens 120-132 12235811-3 2001 Congo-red birefringency and thioflavin-S reactivity in NFT-bearing neurons also demonstrated that the tau aggregation forms a beta-sheet structure. Congo Red 0-9 microtubule associated protein tau Homo sapiens 102-105 11418618-8 2001 Affinity capillary electrophoresis experiments showed increased specific interactions of the nonnative beta(2)-microglobulin conformation with the dyes 8-anilino-1-naphthalene sulfonic acid and Congo red. Congo Red 194-203 beta-2-microglobulin Homo sapiens 103-124 11788051-8 2001 Along with this increased CD45 expression, there was a correlative reduction in staining by Congo red, which stains compact plaques. Congo Red 92-101 protein tyrosine phosphatase, receptor type, C Mus musculus 26-30 11549733-6 2001 The lipid release mediated by Abeta was abolished by concomitant treatment with Congo red and the PKC inhibitor, H7, whereas it was not inhibited with N-acetyl-l-cysteine. Congo Red 80-89 amyloid beta precursor protein Homo sapiens 30-35 11019858-0 2000 Histidine residues underlie Congo red binding to A beta analogs. Congo Red 28-37 amyloid beta precursor protein Homo sapiens 49-55 11423547-5 2001 These non-fibrillar A beta aggregates displayed much weaker Congo Red birefringence, and in separate cell culture experiments, were less toxic than self beta-aggregates, as demonstrated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay. Congo Red 60-69 amyloid beta precursor protein Homo sapiens 20-26 11100875-0 2000 Congophilicity (Congo red affinity) of different beta2-microglobulin conformations characterized by dye affinity capillary electrophoresis. Congo Red 16-25 beta-2-microglobulin Homo sapiens 49-68 11410601-4 2001 Amyloid fibrils from insulin and the variable domain of Ig light chain demonstrate induced CD spectra upon binding to Congo red. Congo Red 118-127 insulin Homo sapiens 21-28 11123317-6 2001 Functional studies revealed that the integrity of T410 and T412 is also critical for CD5-mediated phosphatidylcholine-specific phospholipase C (PC-PLC) activation and phorbol ester-mediated inhibition of Ab-induced internalization of CD5. Congo Red 50-54 CD5 molecule Homo sapiens 85-88 11123317-6 2001 Functional studies revealed that the integrity of T410 and T412 is also critical for CD5-mediated phosphatidylcholine-specific phospholipase C (PC-PLC) activation and phorbol ester-mediated inhibition of Ab-induced internalization of CD5. Congo Red 50-54 CD5 molecule Homo sapiens 234-237 11123317-7 2001 These results strongly argue in favor of a role for T410 and T412 in the signaling mediated by CD5. Congo Red 52-56 CD5 molecule Homo sapiens 95-98 11100875-2 2000 CE could separate conformational variants of beta2-microglobulin and with the amyloid-specific dye Congo red as a buffer additive it was possible to measure different Congo red-affinities of native and abnormally folded beta2-microglobulin. Congo Red 99-108 beta-2-microglobulin Homo sapiens 220-239 11100875-2 2000 CE could separate conformational variants of beta2-microglobulin and with the amyloid-specific dye Congo red as a buffer additive it was possible to measure different Congo red-affinities of native and abnormally folded beta2-microglobulin. Congo Red 167-176 beta-2-microglobulin Homo sapiens 220-239 11100875-3 2000 We find that native beta2-microglobulin has an intermediate affinity for Congo red at pH 7.3 and that binding involves electrostatic interactions. Congo Red 73-82 beta-2-microglobulin Homo sapiens 20-39 11100875-4 2000 The conformational variant of beta2-microglobulin that appears in acetonitrile solutions binds Congo red more strongly. Congo Red 95-104 beta-2-microglobulin Homo sapiens 30-49 11019858-1 2000 The binding mechanism of Congo red (CR) to Alzheimer"s disease (AD) amyloid fibrils (A beta) in terms of binding affinity and number of sites was quantitated from absorption spectroscopy (at 200-700 nm) by measuring the concentration of CR bound (CR-B) to AD A beta assemblies as a function of CR concentration and pH in 80% ethanol. Congo Red 25-34 amyloid beta precursor protein Homo sapiens 85-91 11019858-1 2000 The binding mechanism of Congo red (CR) to Alzheimer"s disease (AD) amyloid fibrils (A beta) in terms of binding affinity and number of sites was quantitated from absorption spectroscopy (at 200-700 nm) by measuring the concentration of CR bound (CR-B) to AD A beta assemblies as a function of CR concentration and pH in 80% ethanol. Congo Red 25-34 amyloid beta precursor protein Homo sapiens 259-265 11019858-1 2000 The binding mechanism of Congo red (CR) to Alzheimer"s disease (AD) amyloid fibrils (A beta) in terms of binding affinity and number of sites was quantitated from absorption spectroscopy (at 200-700 nm) by measuring the concentration of CR bound (CR-B) to AD A beta assemblies as a function of CR concentration and pH in 80% ethanol. Congo Red 36-38 amyloid beta precursor protein Homo sapiens 85-91 11019858-1 2000 The binding mechanism of Congo red (CR) to Alzheimer"s disease (AD) amyloid fibrils (A beta) in terms of binding affinity and number of sites was quantitated from absorption spectroscopy (at 200-700 nm) by measuring the concentration of CR bound (CR-B) to AD A beta assemblies as a function of CR concentration and pH in 80% ethanol. Congo Red 36-38 amyloid beta precursor protein Homo sapiens 259-265 11019858-1 2000 The binding mechanism of Congo red (CR) to Alzheimer"s disease (AD) amyloid fibrils (A beta) in terms of binding affinity and number of sites was quantitated from absorption spectroscopy (at 200-700 nm) by measuring the concentration of CR bound (CR-B) to AD A beta assemblies as a function of CR concentration and pH in 80% ethanol. Congo Red 237-239 amyloid beta precursor protein Homo sapiens 85-91 11019858-1 2000 The binding mechanism of Congo red (CR) to Alzheimer"s disease (AD) amyloid fibrils (A beta) in terms of binding affinity and number of sites was quantitated from absorption spectroscopy (at 200-700 nm) by measuring the concentration of CR bound (CR-B) to AD A beta assemblies as a function of CR concentration and pH in 80% ethanol. Congo Red 237-239 amyloid beta precursor protein Homo sapiens 85-91 11019858-1 2000 The binding mechanism of Congo red (CR) to Alzheimer"s disease (AD) amyloid fibrils (A beta) in terms of binding affinity and number of sites was quantitated from absorption spectroscopy (at 200-700 nm) by measuring the concentration of CR bound (CR-B) to AD A beta assemblies as a function of CR concentration and pH in 80% ethanol. Congo Red 237-239 amyloid beta precursor protein Homo sapiens 85-91 11019858-11 2000 That histidine residues underlie CR binding in A beta amyloid is consistent with previous findings that A beta peptides sediment as fibrillar assemblies at pH-3-7 and bind Congo red over the same pH range in aqueous medium. Congo Red 33-35 amyloid beta precursor protein Homo sapiens 47-53 11019858-11 2000 That histidine residues underlie CR binding in A beta amyloid is consistent with previous findings that A beta peptides sediment as fibrillar assemblies at pH-3-7 and bind Congo red over the same pH range in aqueous medium. Congo Red 33-35 amyloid beta precursor protein Homo sapiens 104-110 11019858-11 2000 That histidine residues underlie CR binding in A beta amyloid is consistent with previous findings that A beta peptides sediment as fibrillar assemblies at pH-3-7 and bind Congo red over the same pH range in aqueous medium. Congo Red 172-181 amyloid beta precursor protein Homo sapiens 47-53 11019858-11 2000 That histidine residues underlie CR binding in A beta amyloid is consistent with previous findings that A beta peptides sediment as fibrillar assemblies at pH-3-7 and bind Congo red over the same pH range in aqueous medium. Congo Red 172-181 amyloid beta precursor protein Homo sapiens 104-110 10757808-4 2000 These genes were renamed CRH1 and CRH2, respectively, for Congo red hypersensitive. Congo Red 58-67 transglycosylase Saccharomyces cerevisiae S288C 25-29 10940220-0 2000 A beta fibrillogenesis: kinetic parameters for fibril formation from congo red binding. Congo Red 69-78 amyloid beta precursor protein Homo sapiens 0-6 10940227-3 2000 We describe in detail the morphological development of the Abeta polymerization process from pseudo-spherical structures and protofibrils to mature thioflavin-T-positive/Congo red-positive amyloid fibrils. Congo Red 170-179 amyloid beta precursor protein Homo sapiens 59-64 10913285-2 2000 Using Congo red and thioflavin-T binding, electron microscopy, and X-ray fiber diffraction, we have determined conditions under which recombinant monomeric beta(2)m spontaneously associates to form fibrils in vitro. Congo Red 6-15 beta-2-microglobulin Homo sapiens 156-164 10889036-1 2000 Human apolipoprotein C-II (apoC-II) self-associates in solution to form aggregates with the characteristics of amyloid including red-green birefringence in the presence of Congo Red under cross-polarized light, increased fluorescence in the presence of thioflavin T, and a fibrous structure when examined by electron microscopy. Congo Red 172-181 apolipoprotein C2 Homo sapiens 6-25 10889036-1 2000 Human apolipoprotein C-II (apoC-II) self-associates in solution to form aggregates with the characteristics of amyloid including red-green birefringence in the presence of Congo Red under cross-polarized light, increased fluorescence in the presence of thioflavin T, and a fibrous structure when examined by electron microscopy. Congo Red 172-181 apolipoprotein C2 Homo sapiens 27-34 10757808-4 2000 These genes were renamed CRH1 and CRH2, respectively, for Congo red hypersensitive. Congo Red 58-67 Utr2p Saccharomyces cerevisiae S288C 34-38 10739940-3 2000 The X-ray diffraction pattern and ability to bind Congo red characterize the alpha-L-iduronidase spherulite as "amyloid-like", in that it displays two of the characteristics of amyloidogenic proteins. Congo Red 50-59 alpha-L-iduronidase Homo sapiens 77-96 10892291-3 2000 The amyloid fibril formation of purified TTR was monitored by the turbidity at 330 nm, and by a Congo red binding assay as a function of pH. Congo Red 96-105 transthyretin Oryctolagus cuniculus 41-44 10892291-4 2000 The S-sulfonated TTR showed clear elevation of the turbidity and Congo red binding under acidic conditions. Congo Red 65-74 transthyretin Oryctolagus cuniculus 17-20 10690926-7 2000 Thioflavin S and Congo red staining indicated a beta-pleated sheet conformation of the A beta deposits, implying formation of fibrils. Congo Red 17-26 amyloid beta precursor protein Rattus norvegicus 46-52 10818488-5 2000 In addition, vascular A beta deposits and mature A beta plaques stained by Congo red in AD brains contained more A beta 40 than A beta 42, whereas Congo red-negative immature plaques mainly consisted of A beta 42. Congo Red 75-84 amyloid beta precursor protein Homo sapiens 49-55 10818488-5 2000 In addition, vascular A beta deposits and mature A beta plaques stained by Congo red in AD brains contained more A beta 40 than A beta 42, whereas Congo red-negative immature plaques mainly consisted of A beta 42. Congo Red 75-84 amyloid beta precursor protein Homo sapiens 49-55 10818488-5 2000 In addition, vascular A beta deposits and mature A beta plaques stained by Congo red in AD brains contained more A beta 40 than A beta 42, whereas Congo red-negative immature plaques mainly consisted of A beta 42. Congo Red 75-84 amyloid beta precursor protein Homo sapiens 49-55 10818488-5 2000 In addition, vascular A beta deposits and mature A beta plaques stained by Congo red in AD brains contained more A beta 40 than A beta 42, whereas Congo red-negative immature plaques mainly consisted of A beta 42. Congo Red 75-84 amyloid beta precursor protein Homo sapiens 49-55 10640633-12 2000 Congo red staining and electron microscopic examination in negative staining of aged samples of Abeta alone and Abeta incubated with gelsolin showed that gelsolin inhibits the fibrillization of synthetic Abeta 1-40 and Abeta 1-42 at gelsolin to Abeta molar ratio of 1:40. Congo Red 0-9 gelsolin Homo sapiens 154-162 10640633-12 2000 Congo red staining and electron microscopic examination in negative staining of aged samples of Abeta alone and Abeta incubated with gelsolin showed that gelsolin inhibits the fibrillization of synthetic Abeta 1-40 and Abeta 1-42 at gelsolin to Abeta molar ratio of 1:40. Congo Red 0-9 gelsolin Homo sapiens 154-162 10725446-0 2000 Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells. Congo Red 10-19 prion protein Homo sapiens 84-87 10690926-7 2000 Thioflavin S and Congo red staining indicated a beta-pleated sheet conformation of the A beta deposits, implying formation of fibrils. Congo Red 17-26 amyloid beta precursor protein Rattus norvegicus 87-93 10585501-12 1999 Moreover, when a synthetic peptide from this TIM segment was studied in vitro, it was able to aggregate and to form amyloid fibrils, as established by Congo red binding and electron microscopy. Congo Red 151-160 triosephosphate isomerase 1 Homo sapiens 45-48 11214931-0 2000 Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs. Congo Red 97-106 prion protein Homo sapiens 46-59 11214931-1 2000 Five compounds related to Congo Red were found to inhibit generation of protease-resistant prion protein in a cell-free system. Congo Red 26-35 prion protein Homo sapiens 91-104 10617123-4 2000 Compounds such as glycosaminoglycans and Congo red (CR) have been shown to interfere with both in vitro and in vivo PrP(Sc) formation. Congo Red 41-50 prion protein Mus musculus 116-119 10617123-4 2000 Compounds such as glycosaminoglycans and Congo red (CR) have been shown to interfere with both in vitro and in vivo PrP(Sc) formation. Congo Red 52-54 prion protein Mus musculus 116-119 10617123-5 2000 It was hypothesized that CR acts by overstabilizing the conformation of PrP(Sc) molecules or by modifying trafficking of PrP(C). Congo Red 25-27 prion protein Mus musculus 72-75 10617123-5 2000 It was hypothesized that CR acts by overstabilizing the conformation of PrP(Sc) molecules or by modifying trafficking of PrP(C). Congo Red 25-27 prion protein Mus musculus 121-124 10617123-8 2000 This last observation suggests an alternative mechanism of action of CR and leads us to reconsider the relationship between the biochemical properties of PrP and conformational alteration of the protein. Congo Red 69-71 prion protein Mus musculus 154-157 10585968-7 1999 In vitro, Ure2p and Sup35p form amyloid, a filamentous protein structure, high in beta-sheet with a characteristic green birefringent staining by the dye Congo Red. Congo Red 154-163 glutathione peroxidase Saccharomyces cerevisiae S288C 10-15 10585968-7 1999 In vitro, Ure2p and Sup35p form amyloid, a filamentous protein structure, high in beta-sheet with a characteristic green birefringent staining by the dye Congo Red. Congo Red 154-163 translation termination factor GTPase eRF3 Saccharomyces cerevisiae S288C 20-26 10521263-7 1999 The L55P-TTR protofilaments formed in vitro bind Congo red and thioflavin T (albeit more weakly than the fibrils produced at acidic pH), suggesting that the structure observed probably represents an amyloid precursor. Congo Red 49-58 transthyretin Homo sapiens 9-12 10374747-6 1999 Based upon this literature, it is suggested that the Congo red birefringence generated by NFT is caused by A beta, intimately bound to the NFT. Congo Red 53-62 amyloid beta precursor protein Homo sapiens 107-113 10354415-13 1999 The model also provides a binding mode for Congo red on Abeta amyloid fibrils. Congo Red 43-52 amyloid beta precursor protein Homo sapiens 56-61 10524282-4 1999 Here, the amyloid fibril formation of the TTR isoforms was monitored by the turbidity at 330 nm, and by a Congo red-binding assay as a function of pH, according to the method of Lai et al. Congo Red 106-115 transthyretin Homo sapiens 42-45 10208537-6 1999 NACP/ alpha-synuclein aggregates displayed strong thioflavine-S and congo-red reactivity, reminiscent of amyloid. Congo Red 68-77 synuclein alpha Homo sapiens 0-4 10322008-15 1999 The disruption of CCW12 results in a pronounced sensitivity of the cells to calcofluor white and Congo red. Congo Red 97-106 Ccw12p Saccharomyces cerevisiae S288C 18-23 10208537-6 1999 NACP/ alpha-synuclein aggregates displayed strong thioflavine-S and congo-red reactivity, reminiscent of amyloid. Congo Red 68-77 synuclein alpha Homo sapiens 6-21 9751195-3 1998 Expression of wild-type A beta in these animals leads to rapid production of amyloid deposits reactive with Congo red and thioflavin S. Congo Red 108-117 amyloid beta precursor protein Homo sapiens 24-30 11097025-1 1999 Rylux BSU and congo red bind to chitin, interfere with proper cell-wall assembly, and stimulate chitin synthesis by increasing, most probably, chitin synthase 3 (ChS3) levels in Saccharomyces cerevisiae. Congo Red 14-23 chitin synthase CHS3 Saccharomyces cerevisiae S288C 143-160 11097025-1 1999 Rylux BSU and congo red bind to chitin, interfere with proper cell-wall assembly, and stimulate chitin synthesis by increasing, most probably, chitin synthase 3 (ChS3) levels in Saccharomyces cerevisiae. Congo Red 14-23 chitin synthase CHS3 Saccharomyces cerevisiae S288C 162-166 11097025-3 1999 As ChS3 is the critical target of nikkomycin Z, its effect was tested in cells inhibited in growth by Rylux BSU or Congo red. Congo Red 115-124 chitin synthase CHS3 Saccharomyces cerevisiae S288C 3-7 10219659-2 1999 MATERIAL AND TREATMENT: Elastin-congo red was used as a substrate for elastin degradation assay. Congo Red 32-41 Eln Mesocricetus auratus 24-31 10219659-2 1999 MATERIAL AND TREATMENT: Elastin-congo red was used as a substrate for elastin degradation assay. Congo Red 32-41 Eln Mesocricetus auratus 70-77 9887214-0 1999 Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay. Congo Red 63-72 amyloid beta precursor protein Homo sapiens 34-39 9887214-0 1999 Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay. Congo Red 63-72 amyloid beta precursor protein Homo sapiens 73-78 9887214-0 1999 Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay. Congo Red 63-72 amyloid beta precursor protein Homo sapiens 83-88 9562501-2 1998 We have derived a model of binding for the dye molecule, Congo red (CR), to a beta-sheet structure of beta-amyloid (1-42). Congo Red 57-66 amyloid beta precursor protein Homo sapiens 76-82 9690671-3 1998 However, A beta deposits in the presubiculum are thioflavin-S- and Congo red-negative--and thus, nonfibrillar--even after 11 to 19 years of AD. Congo Red 67-76 amyloid beta precursor protein Homo sapiens 9-15 9568695-6 1998 Using thioflavin T fluorometry, Congo red staining, and electron microscopy methodology, intact perlecan was found to enhance amylin fibril formation in a dosage-dependent manner, with the majority of these effects attributed to the heparan sulfate GAG chains of perlecan. Congo Red 32-41 heparan sulfate proteoglycan 2 Rattus norvegicus 96-104 9520384-8 1998 The RNase A dimer crystals take up the dye Congo Red, but the structure of a Congo Red-stained crystal reveals no bound dye molecule. Congo Red 43-52 ribonuclease pancreatic Bos taurus 4-11 9820124-0 1998 Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells. Congo Red 39-48 amyloid beta precursor protein Rattus norvegicus 59-65 9820124-2 1998 Congo red, a histologic dye that binds to amyloid has previously been shown to diminish the toxic effects of A beta in cell culture. Congo Red 0-9 amyloid beta precursor protein Rattus norvegicus 109-115 9422365-5 1998 The simultaneous addition of an equimolar concentration of the dye Congo red prevents the cell surface fibril assembly of HCHWA-D A beta(1-40). Congo Red 67-76 amyloid beta precursor protein Homo sapiens 130-136 9422365-6 1998 Moreover, Congo red effectively blocks the key pathologic responses induced by HCHWA-D A beta(1-40) in these cells. Congo Red 10-19 amyloid beta precursor protein Homo sapiens 87-93 9422374-0 1998 Congo red inhibits proteoglycan and serum amyloid P binding to amyloid beta fibrils. Congo Red 0-9 amyloid P component, serum Homo sapiens 36-51 9422374-8 1998 It is interesting that both SAP and proteoglycan binding to A beta fibrils can be inhibited by glycosaminoglycans and Congo red. Congo Red 118-127 amyloid P component, serum Homo sapiens 28-31 9422374-8 1998 It is interesting that both SAP and proteoglycan binding to A beta fibrils can be inhibited by glycosaminoglycans and Congo red. Congo Red 118-127 amyloid beta precursor protein Homo sapiens 60-66 9422374-9 1998 Unexpectedly, Congo red protects fibrillar A beta from breakdown, suggesting that this compound and other structurally related molecules are unlikely to be suitable for use in the treatment of Alzheimer"s disease. Congo Red 14-23 amyloid beta precursor protein Homo sapiens 43-49 9562501-2 1998 We have derived a model of binding for the dye molecule, Congo red (CR), to a beta-sheet structure of beta-amyloid (1-42). Congo Red 68-70 amyloid beta precursor protein Homo sapiens 76-82 9562501-3 1998 This model is based on the crystal coordinates of CR binding to porcine insulin fibrils from Turnell and Finch. Congo Red 50-52 insulin Homo sapiens 72-79 9562501-4 1998 Intact insulin is composed of protein dimers and X-ray diffraction studies show that CR intercalates between two insulin monomers at an interface formed by a pair of antiparallel beta-strands. Congo Red 85-87 insulin Homo sapiens 7-14 9562501-4 1998 Intact insulin is composed of protein dimers and X-ray diffraction studies show that CR intercalates between two insulin monomers at an interface formed by a pair of antiparallel beta-strands. Congo Red 85-87 insulin Homo sapiens 113-120 9359461-1 1997 An amyloid-binding dye Congo red has been reported to prevent the neurotoxic effect of Alzheimer"s amyloid beta protein (Abeta). Congo Red 23-32 amyloid beta precursor protein Rattus norvegicus 121-126 9359461-6 1997 The reversing effect of Congo red cannot be explained by the inhibition of Abeta fibril formation and suggests a novel aspect of the interaction of Congo red with Abeta. Congo Red 24-33 amyloid beta precursor protein Rattus norvegicus 163-168 9359461-6 1997 The reversing effect of Congo red cannot be explained by the inhibition of Abeta fibril formation and suggests a novel aspect of the interaction of Congo red with Abeta. Congo Red 148-157 amyloid beta precursor protein Rattus norvegicus 163-168 9476121-8 1997 Congo red, a histochemical stain for amyloid deposits and an inhibitor of amyloid aggregation, reduces C3 convertase activity on aggregated A beta 1-42, indicated by decreased C3a production. Congo Red 0-9 complement C3 Homo sapiens 176-179 9359461-4 1997 Congo red (0.2-20 microM), when added together with or prior to Abeta, significantly blocked Abeta-induced inhibition of redox activity. Congo Red 0-9 amyloid beta precursor protein Rattus norvegicus 64-69 9359461-4 1997 Congo red (0.2-20 microM), when added together with or prior to Abeta, significantly blocked Abeta-induced inhibition of redox activity. Congo Red 0-9 amyloid beta precursor protein Rattus norvegicus 93-98 9359461-5 1997 Furthermore, when Congo red was added after treatment with Abeta, the inhibited redox activity was restored to normal, indicating that Congo red can reverse Abeta-induced cellular stress. Congo Red 18-27 amyloid beta precursor protein Rattus norvegicus 59-64 9359461-5 1997 Furthermore, when Congo red was added after treatment with Abeta, the inhibited redox activity was restored to normal, indicating that Congo red can reverse Abeta-induced cellular stress. Congo Red 18-27 amyloid beta precursor protein Rattus norvegicus 157-162 9359461-5 1997 Furthermore, when Congo red was added after treatment with Abeta, the inhibited redox activity was restored to normal, indicating that Congo red can reverse Abeta-induced cellular stress. Congo Red 135-144 amyloid beta precursor protein Rattus norvegicus 59-64 9359461-5 1997 Furthermore, when Congo red was added after treatment with Abeta, the inhibited redox activity was restored to normal, indicating that Congo red can reverse Abeta-induced cellular stress. Congo Red 135-144 amyloid beta precursor protein Rattus norvegicus 157-162 9359461-6 1997 The reversing effect of Congo red cannot be explained by the inhibition of Abeta fibril formation and suggests a novel aspect of the interaction of Congo red with Abeta. Congo Red 24-33 amyloid beta precursor protein Rattus norvegicus 75-80 9048759-7 1997 Both cell death and amyloid precursor protein production could be inhibited by the amyloid-binding dye Congo red, suggesting that fibril assembly of A beta is crucial for initiating its destructive effects. Congo Red 103-112 amyloid beta precursor protein Homo sapiens 149-155 9202333-3 1997 In this report, we show that the fibrillar aggregation state of A beta, as determined by thioflavin T fluorometry, electron microscopy, and staining with Congo red and thioflavine S, is precisely correlated with the ability of the peptide to induce the formation of activated fragments of the complement proteins C4 and C3. Congo Red 154-163 amyloid beta precursor protein Homo sapiens 64-70 9153600-8 1997 The absence of Congo red staining prion protein plaques is probably attributable to E219K polymorphism on the same allele of the PrP gene. Congo Red 15-24 prion protein Homo sapiens 129-132 7899829-3 1995 The antiserum raised against the purified SAA stained Congo red positive regions in the kidney of an AA-amyloidotic cow and reacted on Western blot with an AA-related protein of approximately 14 kDa. Congo Red 54-63 serum amyloid A protein Bos taurus 42-45 8810256-3 1996 Numerous Abeta plaques that stained with Congo red dye were present in cortical and limbic structures of mice with elevated amounts of Abeta. Congo Red 41-50 amyloid beta (A4) precursor protein Mus musculus 9-14 8810256-3 1996 Numerous Abeta plaques that stained with Congo red dye were present in cortical and limbic structures of mice with elevated amounts of Abeta. Congo Red 41-50 amyloid beta (A4) precursor protein Mus musculus 135-140 7545479-3 1995 Functional structures of serum proteinase inhibitors and haptoglobins induced by interaction of these proteins with their natural substrates were found to bind Congo Red. Congo Red 160-169 endogenous retrovirus group K member 10 Homo sapiens 31-41 7770727-4 1995 The degraded SAA molecules lacking nine or more amino-terminal residues, when exposed to in vitro fibril-forming conditions, failed to form Congo red positive precipitates and did not show amyloid fibril-like structure by electron microscopy. Congo Red 140-149 serum amyloid A1 Homo sapiens 13-16 7489836-4 1995 IAPP-positive amyloid was seen in 16 out of 22 transplants (73%), either by polarisation microscopy after Congo red staining or by immune electron microscopy. Congo Red 106-115 islet amyloid polypeptide Homo sapiens 0-4 9007091-8 1996 In the sporadic form, ApoE-immunoreactive deposits colocalized with Congo red-positive deposits; however, in muscle fibers from patients with hereditary disease there was no congophilia. Congo Red 68-77 apolipoprotein E Homo sapiens 22-26 8624132-10 1996 The amyloid fibril-binding dye Congo red inhibited the toxicity of both beta A and amylin. Congo Red 31-40 islet amyloid polypeptide Rattus norvegicus 72-89 7653483-8 1995 Beta 2-microglobulin amyloid was identified by Congo red staining and immunohistology. Congo Red 47-56 beta-2-microglobulin Homo sapiens 0-20 7639323-8 1995 The intact apo A1 can itself form amyloid-like fibrils in vitro that are Congo Red positive. Congo Red 73-82 apolipoprotein A1 Homo sapiens 11-17 7768807-8 1995 The cwp2 deletion mutant displayed an increased sensitivity to Congo red, calcofluor white, and Zymolyase. Congo Red 63-72 Cwp2p Saccharomyces cerevisiae S288C 4-8 7768807-11 1995 Depletion of Cwp1p or Tip1p also caused increased sensitivities to Congo red and calcofluor white, but the effects were less pronounced than for cwp2 delta. Congo Red 67-76 Cwp1p Saccharomyces cerevisiae S288C 13-18 7768807-11 1995 Depletion of Cwp1p or Tip1p also caused increased sensitivities to Congo red and calcofluor white, but the effects were less pronounced than for cwp2 delta. Congo Red 67-76 putative lipase Saccharomyces cerevisiae S288C 22-27 7715296-4 1995 In vitro this fragment from recombinant apolipoprotein E could form amyloid-like fibrils, which were Congo-red positive. Congo Red 101-110 apolipoprotein E Homo sapiens 40-56 7852387-3 1995 The single mutation of valine 18 to alanine induces a significant increment of the alpha-helical content of A beta, determined by Fourier transform infrared spectroscopy and circular dichroism and dramatically diminishes fibrillogenesis, measured by turbidity, thioflavine T binding, Congo red staining, and electron microscopic examination. Congo Red 284-293 amyloid beta precursor protein Homo sapiens 108-114 7696573-4 1994 Congo Red also inhibits the neurotoxic effects of the human pancreatic amyloidogenic peptide amylin. Congo Red 0-9 islet amyloid polypeptide Homo sapiens 93-99 8525803-10 1995 The deposits were thioflavin S and Congo red positive, indicating that the BAP was in a consolidated form. Congo Red 35-44 SIL1 nucleotide exchange factor Homo sapiens 75-78 7983747-1 1995 In scrapie-infected cells, Congo red inhibits both the replication of the infectious agent and accumulation of the protease-resistant form of PrP (PrP-res). Congo Red 27-36 prion protein Homo sapiens 142-145 7983747-1 1995 In scrapie-infected cells, Congo red inhibits both the replication of the infectious agent and accumulation of the protease-resistant form of PrP (PrP-res). Congo Red 27-36 prion protein Homo sapiens 147-150 7794524-6 1995 Characterization of the AAT-LA complexes by Congo red binding, polarization and negative staining electron microscopy provided clear evidence that AAT, under chosen experimental conditions, can self-assemble into amyloid fibrils, compatible with accepted models of fibrillar structures. Congo Red 44-53 serpin family A member 1 Homo sapiens 24-27 7852916-4 1995 RESULTS: The lambda fibrils could be completely disaggregated (as shown by light and electron microscopy and Congo red uptake) by alpha-1-AT added in the molar ratio 1:5, whereas fibrils with predominantly kappa chains remained unaffected. Congo Red 109-118 serpin family A member 1 Homo sapiens 130-140 8030949-4 1994 Using scrapie-infected neuroblastoma cells to screen for such compounds in vitro, we found that the amyloid binding dye Congo red and certain sulfated glycans potently inhibited the accumulation of protease-resistant PrP in scrapie-infected cells without apparent effects on the metabolism of the normal isoform. Congo Red 120-129 prion protein Homo sapiens 217-220 7991613-7 1994 Congo red also inhibited the pancreatic islet cell toxicity of diabetes-associated amylin, another type of amyloid fibril. Congo Red 0-9 islet amyloid polypeptide Rattus norvegicus 83-89 7812655-4 1994 With this in vitro system, Congo red and several sulfated polysaccharides, including heparin and pentosan polysulfate, were found to inhibit accumulation of protease-resistant PrP. Congo Red 27-36 prion protein Homo sapiens 176-179 7511169-0 1994 Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected]. Congo Red 96-105 prion protein Mus musculus 42-45 7511169-1 1994 Congo red and certain sulfated glycans are potent inhibitors of protease-resistant PrP accumulation in scrapie-infected cells. Congo Red 0-9 prion protein Mus musculus 83-86 7511169-3 1994 Accordingly, we have investigated whether the apparent precursor of protease-resistant PrP, protease-sensitive PrP, binds to Congo red and heparin, a highly sulfated glycosaminoglycan with an inhibitory potency like that of heparan sulfate. Congo Red 125-134 prion protein Mus musculus 87-90 7511169-3 1994 Accordingly, we have investigated whether the apparent precursor of protease-resistant PrP, protease-sensitive PrP, binds to Congo red and heparin, a highly sulfated glycosaminoglycan with an inhibitory potency like that of heparan sulfate. Congo Red 125-134 prion protein Mus musculus 111-114 7511169-4 1994 Protease-sensitive PrP released from the surface of mouse neuroblastoma cells bound to heparin-agarose and Congo red-glass beads. Congo Red 107-116 prion protein Mus musculus 19-22 7511169-6 1994 Free Congo red blocked PrP binding to heparin and vice versa, suggesting that these ligands share a common binding site. Congo Red 5-14 prion protein Mus musculus 23-26 7511169-7 1994 The relative efficacies of pentosan polysulfate, Congo red, heparin, and chondroitin sulfate in blocking PrP binding to heparin-agarose corresponded with their previously demonstrated potencies in inhibiting protease-resistant PrP accumulation. Congo Red 49-58 prion protein Mus musculus 105-108 7511169-8 1994 These results are consistent with the idea that sulfated glycans and Congo red inhibit protease-resistant PrP accumulation by interfering with the interaction of PrP with an endogenous glycosaminoglycan or proteoglycan. Congo Red 69-78 prion protein Mus musculus 106-109 7511169-8 1994 These results are consistent with the idea that sulfated glycans and Congo red inhibit protease-resistant PrP accumulation by interfering with the interaction of PrP with an endogenous glycosaminoglycan or proteoglycan. Congo Red 69-78 prion protein Mus musculus 162-165 8311117-9 1994 In cerebellum, all plaques containing amyloid cores that were Congo red-positive were also positive for highly sulfated GAGs (by Alcian blue staining at 0.7 mol/L MgCl2) and HSPG (both core protein and GAG chain) immunoreactivity. Congo Red 62-71 CD44 molecule (Indian blood group) Homo sapiens 174-178 7999307-6 1994 Inhibitors of protease-resistant PrP accumulation have been identified, and these include the amyloid-binding dye Congo red and certain sulfated glycans. Congo Red 114-123 prion protein Mus musculus 33-36 8117087-1 1994 Heterologous expression of the Clostridium cellulovorans engB gene by Clostridium acetobutylicum BKW-1 was detected as zones of hydrolysis on carboxymethyl cellulose (CMC) Trypticase glucose yeast plates stained with Congo red. Congo Red 217-226 engB Clostridium acetobutylicum ATCC 824 57-61 8395367-3 1993 Immunostaining also revealed the presence of gelsolin in the tubular epithelium that was Congo-red negative. Congo Red 89-98 gelsolin Homo sapiens 45-53 8292358-2 1994 One hundred percent of animals receiving infusions of synthetic beta-amyloid protein (A beta 1-40) plus a specific heparan sulfate proteoglycan (HSPG) for 1 week or 7 weeks (following 2 week infusions) demonstrated Congo red and thioflavin S-positive deposits adjacent to the infusion site. Congo Red 215-224 syndecan 2 Rattus norvegicus 115-143 8292358-2 1994 One hundred percent of animals receiving infusions of synthetic beta-amyloid protein (A beta 1-40) plus a specific heparan sulfate proteoglycan (HSPG) for 1 week or 7 weeks (following 2 week infusions) demonstrated Congo red and thioflavin S-positive deposits adjacent to the infusion site. Congo Red 215-224 syndecan 2 Rattus norvegicus 145-149 8292358-4 1994 Significant increases in Congo red staining were observed in animals infused with A beta plus HSPG versus those infused with only A beta. Congo Red 25-34 amyloid beta precursor protein Rattus norvegicus 82-88 8292358-4 1994 Significant increases in Congo red staining were observed in animals infused with A beta plus HSPG versus those infused with only A beta. Congo Red 25-34 syndecan 2 Rattus norvegicus 94-98 8292358-4 1994 Significant increases in Congo red staining were observed in animals infused with A beta plus HSPG versus those infused with only A beta. Congo Red 25-34 amyloid beta precursor protein Rattus norvegicus 130-136 8292358-6 1994 By 7 weeks, only animals infused with A beta plus HSPG demonstrated compaction of the Congo red material from amorphous, wispy deposits (at 1 week) to stellate deposits resembling a Maltese cross. Congo Red 86-95 amyloid beta precursor protein Rattus norvegicus 38-44 8292358-6 1994 By 7 weeks, only animals infused with A beta plus HSPG demonstrated compaction of the Congo red material from amorphous, wispy deposits (at 1 week) to stellate deposits resembling a Maltese cross. Congo Red 86-95 syndecan 2 Rattus norvegicus 50-54 8137133-5 1993 Congo red and certain sulfated glycans potently inhibit protease-resistant PrP formation or stabilization in cell culture. Congo Red 0-9 prion protein Homo sapiens 75-78 8103804-1 1993 Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Congo Red 0-9 prion protein Mus musculus 58-61 7678300-3 1993 Pentosan polysulfate, like the amyloid-binding dye Congo red, potently inhibited the accumulation of PrP-res in these cells without apparent effects on the metabolism of the normal isoform. Congo Red 51-60 prion protein Homo sapiens 101-104 1729018-3 1992 The plasma level of beta 2-microglobulin in this patient was elevated, and bone specimens from the fracture site demonstrated positive Congo-red staining, suggesting an association with amyloid deposition. Congo Red 135-144 beta-2-microglobulin Homo sapiens 20-40 1280700-8 1992 Among them, only the reaction of anti-amyloid P component had significantly distinctive localization to A beta 2M deposits, which were identified in adjacent serial sections by Congo red staining and immunohistochemical reaction against anti-beta 2m. Congo Red 177-186 beta-2-microglobulin Homo sapiens 106-113 8093237-1 1993 The binding of human fibronectin and Congo red by an autoaggregative Salmonella enteritidis strain was found to be dependent on its ability to produce thin, aggregative fimbriae, named SEF 17 (for Salmonella enteritidis fimbriae with an apparent fimbrin molecular mass of 17 kDa). Congo Red 37-46 interleukin 17 receptor D Homo sapiens 185-188 8093237-3 1993 SEF 17-negative TnphoA mutants which retained the ability to produce SEF 14 and SEF 21 were unable to bind human fibronectin or Congo red and lost the ability to autoaggregate. Congo Red 128-137 interleukin 17 receptor D Homo sapiens 0-3 1433294-0 1992 Binding of the dye congo red to the amyloid protein pig insulin reveals a novel homology amongst amyloid-forming peptide sequences. Congo Red 19-28 insulin Sus scrofa 56-63 24242965-0 1991 Aortic elastin fluorescence afterin vivo labeling with Congo red. Congo Red 55-64 elastin Oryctolagus cuniculus 7-14 1647136-8 1991 Congo-red-positive amyloid deposits present in tumors also were IAPP immunoreactive. Congo Red 0-9 islet amyloid polypeptide Mus musculus 64-68 24242965-1 1991 Congo red (CR) is an azo dye which not only preferentially binds to elastin, an extracellular matrix protein found in the media of arterial vessel walls, but also fluoresces when it binds to this protein. Congo Red 0-9 elastin Oryctolagus cuniculus 68-75 24242965-1 1991 Congo red (CR) is an azo dye which not only preferentially binds to elastin, an extracellular matrix protein found in the media of arterial vessel walls, but also fluoresces when it binds to this protein. Congo Red 11-13 elastin Oryctolagus cuniculus 68-75 24242965-3 1991 The saturation point of CR to elastin was attained when 400 mug CR was added to 20 mg elastin suspension. Congo Red 24-26 elastin Oryctolagus cuniculus 30-37 24242965-3 1991 The saturation point of CR to elastin was attained when 400 mug CR was added to 20 mg elastin suspension. Congo Red 24-26 elastin Oryctolagus cuniculus 86-93 24242965-6 1991 Therefore, the elastin:CR complex appears to be an ideal system in which the elastin fluorescence could aid in distinguishing between normal and diseased tissue in certain pathological conditions, such as atherosclerosis and some types of breast tumors. Congo Red 23-25 elastin Oryctolagus cuniculus 15-22 1710735-6 1991 Thus CgA appears unique among known synaptically released substances in being present in dystrophic neurites in virtually all classic (i.e., Congo red stainable) plaques and additionally in a subpopulation of preamyloid plaques. Congo Red 141-150 chromogranin A Homo sapiens 5-8 24242965-6 1991 Therefore, the elastin:CR complex appears to be an ideal system in which the elastin fluorescence could aid in distinguishing between normal and diseased tissue in certain pathological conditions, such as atherosclerosis and some types of breast tumors. Congo Red 23-25 elastin Oryctolagus cuniculus 77-84 2296158-9 1990 In a 4-day culture of the AEF-loaded macrophages in a medium containing SAA-rich mouse serum, small masses (less than 15 microns in diameter) of Congo red positive substance were observed scattered adjacent to or surrounded by the macrophages. Congo Red 145-154 serum amyloid A cluster Mus musculus 72-75 2178825-4 1990 Nine of the patients proved to have beta 2-microglobulin amyloid deposits as demonstrated by Congo red staining and by immunofluorescence. Congo Red 93-102 beta-2-microglobulin Homo sapiens 36-56 33808975-8 2021 According to Langmuir isotherm model that best fits the experimental data, the maximum CR/MO adsorption capacity is 162.68/94.46 mg/g for CoFe2O4 and 15.60/66.18 mg/g for CoFe2O4-Chit in single solutions. Congo Red 87-89 chitinase 1 Homo sapiens 179-183 33784064-5 2021 The OECT channel-electrolyte interface was covered with a nanoporous membrane functionalized with Congo red (CR) molecules showing a strong affinity for Abeta aggregates. Congo Red 98-107 amyloid beta precursor protein Homo sapiens 153-158 33784064-5 2021 The OECT channel-electrolyte interface was covered with a nanoporous membrane functionalized with Congo red (CR) molecules showing a strong affinity for Abeta aggregates. Congo Red 109-111 amyloid beta precursor protein Homo sapiens 153-158 33808975-10 2021 In binary solutions, adsorption of CR/MO on CoFe2O4 better follows the pseudo-second-order kinetics model, while the kinetic of CR/MO adsorption on CoFe2O4-Chit is similar to that of the dyes in single-component solutions. Congo Red 35-37 chitinase 1 Homo sapiens 156-160 33808975-10 2021 In binary solutions, adsorption of CR/MO on CoFe2O4 better follows the pseudo-second-order kinetics model, while the kinetic of CR/MO adsorption on CoFe2O4-Chit is similar to that of the dyes in single-component solutions. Congo Red 128-130 chitinase 1 Homo sapiens 156-160 34592066-4 2022 Immunostaining with two types of specific antibodies for Abeta identified the clear presence of Abeta peptides associated with: (1) carcinoma cells and (2) extracellular aggregated amyloid (also revealed by Congo red and thioflavin S staining). Congo Red 207-216 amyloid beta (A4) precursor protein Mus musculus 96-101 33232898-0 2021 Design and optimization of a cavitating device for Congo red decolorization: Experimental investigation and CFD simulation. Congo Red 51-60 complement factor D Homo sapiens 108-111 34906527-11 2022 Additionally, AN-5% (29.41 mug mL-1) reduced >95% of the colouring dyes (10 ppm) such as CONG-R (congo red: 95% in 6 min), METH-O (methyl orange: 97.5% in 7 min), METH-B (methylene blue: 98.3% in 10 min) and RHOD-B (rhodamine B: 99.2% in 5 min). Congo Red 97-106 2'-5' oligoadenylate synthetase 1B Mus musculus 31-35 33032630-1 2020 BACKGROUND: The diagnostic accuracy of histopathological detection of transthyretin amyloid (ATTR) by Congo red staining of abdominal fat samples has been questioned since low sensitivity has been reported, especially for patients with ATTR cardiomyopathy. Congo Red 102-111 transthyretin Homo sapiens 70-83 34742761-6 2022 The mechanism of RhB and CR adsorption was complex where nAg-TC, possessing the synergistic effects of TLB and nAg, showed surface complexation, electrostatic attraction, and H-bonding, leading to chemisorption. Congo Red 25-27 NBAS subunit of NRZ tethering complex Homo sapiens 111-114 34626335-6 2022 The excellent removal effect of CAT ternary composite on Congo red wastewater provided a new idea and way for the modification of TiO2 and its composites for the potential of organic dyes degradation. Congo Red 57-66 catalase Homo sapiens 32-35 34450412-5 2021 The complex shows high sensitivity to fibrillar insulin with a limit of detection of 0.85 muM and binding affinity of 12.40 +- 1.84 muM which is comparable to those of Thioflavin T and Congo red, with the advantage of minimizing background fluorescence, absorption of light by biomolecules, and light scattering from physiologic salts in the medium. Congo Red 185-194 insulin Homo sapiens 48-55 35537620-4 2022 For this purpose, the exposed hydrophobic patches were detected using ANS fluorescence and the formation of hSOD1 aggregates was monitored using the ThT fluorescence and absorption spectra of Congo red (CR). Congo Red 192-201 superoxide dismutase 1 Homo sapiens 108-113 34564516-5 2021 The optimized PES/Fe-TA-PEI membrane possesses high pure water flux (124.6 L m-2 h-1) and excellent dye rejections (98.5%, 99.8%, 98.4%, and 86.4% for Congo red, Eriochrome black T, Alcian blue 8GX, and Bromophenol blue, respectively) under 2 bar operation pressure. Congo Red 151-160 pescadillo ribosomal biogenesis factor 1 Homo sapiens 14-17 34451652-3 2021 When M. nivale was treated with TAD1, Congo red-stainable extracellular polysaccharides (EPS) were produced. Congo Red 38-47 defensin Tk-AMP-D2 Triticum aestivum 32-36 34069103-7 2021 MM66 apt mutants isolated via 2-fluoroadenine selection also demonstrated reduced susceptibility to the cell wall lytic dye Congo red and vancomycin. Congo Red 124-133 AT695_RS09340 Staphylococcus aureus 5-8 34458787-8 2021 These peptidomimetics inhibited the amyloid formation of hIAPP substantially even at low concentration, as evident from in vitro ThT, CD, FT-IR, TEM, and Congo red staining birefringence results. Congo Red 154-163 islet amyloid polypeptide Homo sapiens 57-62 34319254-4 2021 Congo Red Staining was used to detect the distribution of Abeta plaques in the hippocampus of rats. Congo Red 0-9 amyloid beta precursor protein Rattus norvegicus 58-63 35537620-4 2022 For this purpose, the exposed hydrophobic patches were detected using ANS fluorescence and the formation of hSOD1 aggregates was monitored using the ThT fluorescence and absorption spectra of Congo red (CR). Congo Red 203-205 superoxide dismutase 1 Homo sapiens 108-113 35033911-7 2022 Amine groups in S100 offered exceptional selectivity for anionic Congo red (CR) against cationic Methylene blue (MB) dye (separation factor of 208 and 87 in absence and presence of sodium chloride, respectively). Congo Red 65-74 S100 calcium binding protein A1 Homo sapiens 16-20 35316563-3 2022 Here we report high-resolution analysis of cellular inclusion bodies (IBs) of immature human superoxide dismutase (SOD1) mutants using NMR quenched amide hydrogen/deuterium exchange (qHDX), FTIR and Congo red binding. Congo Red 199-208 superoxide dismutase 1 Homo sapiens 115-119 35621372-7 2022 Also, the dye flux and rejection of the GCD-mems can simultaneously remove both methylene blue and Congo red. Congo Red 99-108 guanylate cyclase 2E, pseudogene Homo sapiens 40-43 35579205-4 2022 All seven peptides in isolation formed aggregates during incubation at 37 C. Three 20-amino acid long synthetic spike peptides (sequence 192-211, 601-620, 1166-1185) fulfilled three amyloid fibril criteria: nucleation dependent polymerization kinetics by ThT, Congo red positivity, and ultrastructural fibrillar morphology. Congo Red 261-270 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 113-118 35598510-3 2022 The adsorption properties of the CS-GA/ACP for Congo red (CR) and methylene blue (MB) removal were examined using a batch method. Congo Red 47-56 CPAT1 Homo sapiens 39-42 35598510-3 2022 The adsorption properties of the CS-GA/ACP for Congo red (CR) and methylene blue (MB) removal were examined using a batch method. Congo Red 58-60 CPAT1 Homo sapiens 39-42 35598510-6 2022 The maximum adsorption capacities of the CS-GA/ACP for CR and MB were 180.59 mg/g and 143.67 mg/g at 25 C, respectively. Congo Red 55-57 CPAT1 Homo sapiens 41-50 35563426-1 2022 Congo red (CR) type self-assembled ribbon-like structures (SRLS) were previously shown to interact with some proteins, including albumin. Congo Red 0-9 albumin Homo sapiens 129-136 35563426-1 2022 Congo red (CR) type self-assembled ribbon-like structures (SRLS) were previously shown to interact with some proteins, including albumin. Congo Red 11-13 albumin Homo sapiens 129-136 35563426-9 2022 The presented results show that albumin binds both CR and its complex with Dox. Congo Red 51-53 albumin Homo sapiens 32-39 35563343-4 2022 In order to obtain amyloid structures, regular insulin was incubated at 37 C for 24 h. Congo red absorbance and transmission electron microscopy images validated the formation of amyloid fibrils. Congo Red 88-97 insulin Homo sapiens 47-54 35033911-7 2022 Amine groups in S100 offered exceptional selectivity for anionic Congo red (CR) against cationic Methylene blue (MB) dye (separation factor of 208 and 87 in absence and presence of sodium chloride, respectively). Congo Red 76-78 S100 calcium binding protein A1 Homo sapiens 16-20 35056735-8 2022 Congo red/aniline blue staining revealed that peptide hydrogel DRF3 could be immediately gelled in PBS. Congo Red 0-9 diaphanous related formin 3 Homo sapiens 63-67 35448610-6 2022 Mutational analysis demonstrates that two of the aromatic clusters are required for conferring S. cerevisiae Wsc1-dependent resistance to the glucan synthase inhibitor caspofungin, and the chitin-binding agents Congo red and Calcofluor white. Congo Red 211-220 Slg1p Saccharomyces cerevisiae S288C 109-113 35066432-11 2022 The amyloidosis of BC cells and nerval cells caused by ARSD overexpression was verified with western blotting, immunohistochemical and Congo red staining. Congo Red 135-144 arylsulfatase D Homo sapiens 55-59 35329763-2 2022 Millimeter-sized, bead-type, bio-based lignin/chitosan (Lig/CS) adsorbent was designed for the removal of Congo red (CR), based on the electrostatic attraction, pi-pi stacking, and hydrogen bonding, which were synthesized through the emulsification of the chitosan/lignin mixture followed by chemical cross-linking. Congo Red 106-115 ubiquitin conjugating enzyme E2 K Homo sapiens 56-59 35329763-2 2022 Millimeter-sized, bead-type, bio-based lignin/chitosan (Lig/CS) adsorbent was designed for the removal of Congo red (CR), based on the electrostatic attraction, pi-pi stacking, and hydrogen bonding, which were synthesized through the emulsification of the chitosan/lignin mixture followed by chemical cross-linking. Congo Red 117-119 ubiquitin conjugating enzyme E2 K Homo sapiens 56-59 35329763-6 2022 The adsorption of CR on Lig/CS beads followed the type 1 pseudo-second-order model, and the removal rate for CR was still above 90% at five cycles. Congo Red 18-20 ubiquitin conjugating enzyme E2 K Homo sapiens 24-27 35329763-6 2022 The adsorption of CR on Lig/CS beads followed the type 1 pseudo-second-order model, and the removal rate for CR was still above 90% at five cycles. Congo Red 109-111 ubiquitin conjugating enzyme E2 K Homo sapiens 24-27 3418110-0 1988 Congo red binding of elastin in aortic smooth muscle cell cultures. Congo Red 0-9 elastin Homo sapiens 21-28 2666510-0 1989 Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation. Congo Red 27-36 amyloid beta precursor protein Homo sapiens 75-81 2666510-1 1989 The binding of Congo red to several purified amyloid-like peptides having a beta-pleated sheet conformation was quantitatively examined. Congo Red 15-24 amyloid beta precursor protein Homo sapiens 74-80 3418110-1 1988 These studies demonstrate that the strong binding capacity of elastin for Congo red can be used to advantage in aortic smooth muscle cell cultures. Congo Red 74-83 elastin Homo sapiens 62-69 3418110-2 1988 A fibrous elastin network fluoresces when Congo red is added. Congo Red 42-51 elastin Homo sapiens 10-17 3418110-5 1988 Congo red binding to elastin will be useful in studying elastin accumulation and/or degradation in vitro and in vivo. Congo Red 0-9 elastin Homo sapiens 21-28 3418110-5 1988 Congo red binding to elastin will be useful in studying elastin accumulation and/or degradation in vitro and in vivo. Congo Red 0-9 elastin Homo sapiens 56-63 3318271-9 1987 The synthetic cerebrovascular amyloid peptide possesses amyloid-like properties: at neutral pH it forms insoluble aggregates consisting of 5-7-nm fibrils, which form red-green birefringent adducts with Congo red and fluoresce with thioflavine S. Congo Red 202-211 amyloid beta precursor protein Homo sapiens 14-45 2464206-8 1988 Treatment of the tissue with potassium permanganate causes protein AA and B2-microglobulin amyloid to lose their affinity to Congo red. Congo Red 125-134 major histocompatibility complex, class I, G Homo sapiens 74-90 2464206-10 1988 Familial amyloid protein (FAP), prealbumin type, can stand 2 hr of alkaline guanidine treatment without losing its ability to stain with Congo red. Congo Red 137-146 fibroblast activation protein alpha Homo sapiens 0-24 2464206-10 1988 Familial amyloid protein (FAP), prealbumin type, can stand 2 hr of alkaline guanidine treatment without losing its ability to stain with Congo red. Congo Red 137-146 fibroblast activation protein alpha Homo sapiens 26-29 4797239-1 1973 Properties of a solubilized Congo red-elastin complex. Congo Red 29-38 elastin Homo sapiens 39-46 6208743-2 1984 NFT decorated by NF antisera were Congo red-negative. Congo Red 34-43 neurofascin Homo sapiens 0-2 6208743-3 1984 Conversely, PHF antisera stained Congo red-positive NFT but failed to decorate NF-positive NFT. Congo Red 33-42 neurofascin Homo sapiens 52-54 6360758-11 1983 It is of particular interest that the affinity of the amyloid deposits for Congo red stain was totally abolished by prior permanganate treatment, suggesting that the amyloid was derived from serum amyloid A protein rather than from immunoglobulin light chains or insulin aggregates per se. Congo Red 75-84 insulin Canis lupus familiaris 263-270 6188722-6 1983 Analysis of the underlying molecular mechanism for the anisotropic staining reaction of these fibres with Congo red led to the conclusion that this is due to a definite structural order of specific cross-linking segments within the random network of elastin. Congo Red 106-115 elastin Bos taurus 250-257 6174264-8 1982 This enzyme hydrolysed denatured casein and Congo Red-elastin as well as succinyl-L-alanyl-L-alanyl-L-alanyl-p-nitroanilide. Congo Red 44-53 elastin Homo sapiens 54-61 6087305-6 1984 In smears as well as in histological sections amyloid and calcitonin could be demonstrated by congo red staining and by immunocytochemistry, respectively. Congo Red 94-103 calcitonin related polypeptide alpha Homo sapiens 58-68 6360904-2 1984 Of 71 strains which cleared elastin in agar plates, 33 produced elastase in liquid medium, as measured spectrophotometrically with elastin-Congo red. Congo Red 139-148 elastin Mus musculus 131-138 5360689-0 1969 N-acetyl-beta-D-glucosaminidase activity in Congo Red-induced arthritis. Congo Red 44-53 O-GlcNAcase Homo sapiens 0-31 14936957-0 1952 [Influence of desoxycorticosterone acetate and insulin on the elimination of congo red in the blood]. Congo Red 77-86 insulin Homo sapiens 47-54 5971788-4 1966 A method for the estimation of elastase based on the release of dye from Congo Red-stained elastin is described. Congo Red 73-82 elastin Homo sapiens 91-98 32867548-5 2021 Galectin-7 was not present in the dermal amyloid deposits and was only present in the overlying Congo red negative epidermis. Congo Red 96-105 galectin 7 Homo sapiens 0-10 33965487-4 2021 The inhibitory effect of the liquiritigenin against tau amyloid formation was investigated using thioflavin T (ThT) and 1-Anilino-8-naphthalene sulfonate (ANS) fluorescence spectroscopy, Congo red (CR) binding assays, transmission electron microscopy (TEM) analysis, and circular dichroism (CD) spectroscopy. Congo Red 187-196 microtubule associated protein tau Homo sapiens 52-55 33965487-4 2021 The inhibitory effect of the liquiritigenin against tau amyloid formation was investigated using thioflavin T (ThT) and 1-Anilino-8-naphthalene sulfonate (ANS) fluorescence spectroscopy, Congo red (CR) binding assays, transmission electron microscopy (TEM) analysis, and circular dichroism (CD) spectroscopy. Congo Red 198-200 microtubule associated protein tau Homo sapiens 52-55 34017661-8 2021 Subsequent tenosynovial and transverse carpal ligament biopsies were performed with Congo red stain revealing amyloid deposits of TTR monomers. Congo Red 84-93 transthyretin Homo sapiens 130-133 33657492-4 2021 Congo red was completely removed via a single-pass through the nZVCCNT filter (tau <2 s) at neutral pH. Congo Red 0-9 microtubule associated protein tau Homo sapiens 79-82 33705095-2 2021 Small organic fluorophores such as Congo Red preferentially bind to cross-beta-sheet-rich deposits and have been used to label amyloid plaques and tau tangles in histological samples. Congo Red 35-44 microtubule associated protein tau Homo sapiens 147-150 33979123-4 2021 Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity. Congo Red 53-62 angiotensin converting enzyme 2 Homo sapiens 176-181 33979123-4 2021 Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity. Congo Red 53-62 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 191-196 33260706-5 2020 Furthermore, the adsorption results of congo red (CR) and methylene blue (MB) showed AHL-AC6 had greater adsorption capacity than those reported in literature. Congo Red 39-48 adenylate cyclase 6 Homo sapiens 89-92 33546740-5 2021 Fourier transform infrared spectroscopy (FT-IR) and Congo red binding assay highlighted that the THP had a steady alpha-triple helix conformation. Congo Red 52-61 uromodulin Mus musculus 97-100 33562625-5 2021 Overall, this probe delivery via inhalation method is also applicable to other Abeta-binding molecules, such as Congo red, curcumin, and thioflavin T. Congo Red 112-121 amyloid beta (A4) precursor protein Mus musculus 79-84 33020971-8 2021 Although the EFEMP1 deposits were weakly to moderately Congo red-positive with absent to weak birefringence, they were strongly positive for EFEMP1 by immunohistochemistry, had the characteristic fibrillar ultrastructure of amyloid, and were readily identified by mass spectrometry. Congo Red 55-64 EGF containing fibulin extracellular matrix protein 1 Homo sapiens 13-19 33020971-10 2021 Because EFEMP1 amyloid is only weakly Congo red positive it may be overlooked without a high index of suspicion. Congo Red 38-47 EGF containing fibulin extracellular matrix protein 1 Homo sapiens 8-14 33352154-4 2021 Congo red absorbance, circular dichroism (CD), and transmission electron microscopy (TEM) analysis depicted the SiO2 NPs accelerated the formation of alpha-syn amyloid fibrils. Congo Red 0-9 synuclein alpha Homo sapiens 150-159 33053435-3 2021 We monitored the deposition of Abeta plaques in the mouse hippocampus using Congo red staining and measured levels. Congo Red 76-85 amyloid beta (A4) precursor protein Mus musculus 31-36 33398639-7 2021 A homology model for VGLUT2 using D-galactonate transporter (DgoT) to dock and identify R88, H199 and F219 as key protein interactions with Trypan Blue, Congo Red and selected potent analogs prepared and tested in this report. Congo Red 153-162 solute carrier family 17 member 6 Homo sapiens 21-27 33301850-1 2021 In this study, the in vitro assembly of tau and anti-amyloidogenic properties of one naturally occurring phytoestrogen, calycosin, was investigated by spectroscopic techniques including ThT and ANS fluorescence, CD, Congo red absorbance as well as TEM analysis. Congo Red 216-225 microtubule associated protein tau Homo sapiens 40-43 33583309-7 2021 Congo red-positive PTH-deposits were further observed in 6.6% of the parathyroid adenomas analyzed, and were associated with complete/incomplete or absent universal amyloid signature, but with fibrillar morphology at ultrastructural level. Congo Red 0-9 parathyroid hormone Homo sapiens 19-22 33545172-7 2021 The aged rPrP-gel acquired a proteinase-resistant amyloid accompanied by beta-sheet conversion, as confirmed by western blotting, Fourier transform infrared spectroscopy, and Congo red staining. Congo Red 175-184 prion protein Rattus norvegicus 9-13 33142584-6 2021 NCJC/Fe3O4/Ag nanocomposite particles (0.005 mg mL-1) completely degraded 20 mL of 0.1 mM congo red aqueous solution within 13 min aided by NaBH4 reducing agent. Congo Red 90-99 L1 cell adhesion molecule Mus musculus 48-52 32870550-3 2020 To that end, we have designed and synthesized two naphthoquinone-dopamine-based hybrid small molecules, NQDA and Cl-NQDA, and demonstrated their ability to inhibit in vitro amyloid formation by alpha-Syn using ThT assay, CD, TEM, and Congo red birefringence. Congo Red 234-243 synuclein alpha Homo sapiens 194-203 32852699-2 2020 Congo Red (CR) is an anisotropic organic stain discovered to label amyloid beta (Abeta) plaques in the brain. Congo Red 0-9 amyloid beta precursor protein Homo sapiens 81-86 32852699-2 2020 Congo Red (CR) is an anisotropic organic stain discovered to label amyloid beta (Abeta) plaques in the brain. Congo Red 11-13 amyloid beta precursor protein Homo sapiens 81-86 33260706-5 2020 Furthermore, the adsorption results of congo red (CR) and methylene blue (MB) showed AHL-AC6 had greater adsorption capacity than those reported in literature. Congo Red 50-52 adenylate cyclase 6 Homo sapiens 89-92 32917811-6 2020 In contrast to the soluble N-terminal portion, the C-terminal tyrosine-rich fragment of ALIX-PRD forms amyloid fibrils and viscous gels validated using dye-binding assays with amyloid-specific probes, congo red and thioflavin T (ThT), and visualized by transmission electron microscopy. Congo Red 201-210 programmed cell death 6 interacting protein Homo sapiens 88-92 33080787-5 2020 By comparing its phenotype with single, double and triple combinations of MAPK-deletion mutants we were able to unveil a Cek1-independent mechanism for Hog1 resistance to Congo red, and confirm the predominant effect of Hog1 on oxidative and osmotic adaptation. Congo Red 171-180 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 152-156 32150787-6 2020 Exploitation of this hypersensitive phenotype allowed the identification of novel proteins that contribute in signalling to Rlm1 in response to cell-surface stressing agents such as Congo red, zymolyase and sodium dodecyl sulfate (SDS). Congo Red 182-191 Rlm1p Saccharomyces cerevisiae S288C 124-128 33121442-12 2020 CONCLUSIONS: This is a rare case of a TTR-CA with a negative Bone Scintigraphy and Congo red staining, which demonstrated that CA is frequently misdiagnosed because of the low specific clinical manifestations and the results of imaging modalities that sometimes could be misleading, with subsequent delayed diagnosis and correct treatment. Congo Red 83-92 transthyretin Homo sapiens 38-41 32673279-5 2020 As the concentration of artemin was increased up to 4 mug/ml, a decrease in fibril formation of alpha-synuclein was observed using thioflavin T (ThT) fluorescence and congo red (CR) assay. Congo Red 167-176 synuclein alpha Homo sapiens 96-111 32673279-5 2020 As the concentration of artemin was increased up to 4 mug/ml, a decrease in fibril formation of alpha-synuclein was observed using thioflavin T (ThT) fluorescence and congo red (CR) assay. Congo Red 178-180 synuclein alpha Homo sapiens 96-111 32686492-2 2022 The structural characterization of ICP-1 was determined by physical and chemical methods, FT-IR, NMR, SEM, HPGPC, periodate oxidation, Smith degradation, methylation and Congo red test. Congo Red 170-179 ATPase phospholipid transporting 8B1 Homo sapiens 35-40 32590279-6 2020 The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 muM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L). Congo Red 76-78 PWWP domain containing 3A, DNA repair factor Homo sapiens 153-158 31493294-5 2020 Mass spectrometry performed on both the Congo red-positive and Congo red-negative areas identified cochlin as the most abundant protein, as well as a low abundance of universal amyloid signature peptides only in the Congo red-positive areas. Congo Red 40-49 cochlin Homo sapiens 99-106 31291787-5 2020 Fragments of beta-sheets of alpha-1-antitrypsin, complement 3, haptoglobin, ceruloplasmin, and trypstatin were identified as most likely targets for Congo red binding. Congo Red 149-158 serpin family A member 1 Homo sapiens 28-47 31291787-5 2020 Fragments of beta-sheets of alpha-1-antitrypsin, complement 3, haptoglobin, ceruloplasmin, and trypstatin were identified as most likely targets for Congo red binding. Congo Red 149-158 haptoglobin Homo sapiens 63-74