PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32999163-0	2020	Emodin Inhibits Resistance to Imatinib by Downregulation of Bcr-Abl and STAT5 and Allosteric Inhibition in Chronic Myeloid Leukemia Cells.	Emodin	0-6	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	60-67
32999163-0	2020	Emodin Inhibits Resistance to Imatinib by Downregulation of Bcr-Abl and STAT5 and Allosteric Inhibition in Chronic Myeloid Leukemia Cells.	Emodin	0-6	signal transducer and activator of transcription 5A	Homo sapiens	72-77
32999163-2	2020	Emodin, the predominant compound of traditional medicine rhubarb, was reported to inhibit the multidrug resistance by downregulating P-glycoprotein of K562/ADM cells with overexpression of P-glycoprotein in our previous studies.	Emodin	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	133-147
32999163-2	2020	Emodin, the predominant compound of traditional medicine rhubarb, was reported to inhibit the multidrug resistance by downregulating P-glycoprotein of K562/ADM cells with overexpression of P-glycoprotein in our previous studies.	Emodin	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	189-203
32999163-5	2020	After treatment of emodin and imatinib together, the levels of p-Bcr-Abl and Bcr-Abl were significantly downregulated.	Emodin	19-25	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	65-72
32999163-5	2020	After treatment of emodin and imatinib together, the levels of p-Bcr-Abl and Bcr-Abl were significantly downregulated.	Emodin	19-25	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	77-84
32999163-8	2020	Emodin also decreased Src expression and its phosphorylation.	Emodin	0-6	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	22-25
32999163-9	2020	More importantly, emodin simultaneously targeted both the ATP-binding and allosteric sites on Bcr-Abl by molecular docking, with higher affinity with the myristoyl-binding site for enhanced Bcr-Abl kinase inhibition.	Emodin	18-24	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	94-101
32999163-9	2020	More importantly, emodin simultaneously targeted both the ATP-binding and allosteric sites on Bcr-Abl by molecular docking, with higher affinity with the myristoyl-binding site for enhanced Bcr-Abl kinase inhibition.	Emodin	18-24	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	190-197
30676281-7	2020	Emodin and Peruvianoside II showed binding energies -7.2 and -7.0 kcal/mol, respectively, when docked with VWF, whereas Desmopressin displayed less binding energy (-6.9 kcal/mol).	Emodin	0-6	von Willebrand factor	Homo sapiens	107-110
31444412-6	2020	We found that emodin, an inhibitor of phosphoglycerate mutase 1 derived from natural substances, significantly suppressed the glycolysis rate and IR-induced GBM migration in in vivo orthotopic xenograft mouse models.	Emodin	14-20	phosphoglycerate mutase 1	Mus musculus	38-63
31601256-11	2019	Western blot analysis proved that EMO promoted the relative expression of p-perk and p-eIF2alpha and that the expression of its downstream proteins CHOP and GRP78 was also enhanced.	Emodin	34-37	DNA-damage inducible transcript 3	Rattus norvegicus	148-152
31257935-0	2019	Emodin relieves hypoxia-triggered injury via elevation of microRNA-25 in PC-12 cells.	Emodin	0-6	microRNA 25	Rattus norvegicus	58-69
31257935-10	2019	Increased miR-25 was induced by EMO, and inhibited miR-25 abated the impacts of EMO on hypoxia-disposed PC-12 cells.	Emodin	32-35	microRNA 25	Rattus norvegicus	10-16
31257935-10	2019	Increased miR-25 was induced by EMO, and inhibited miR-25 abated the impacts of EMO on hypoxia-disposed PC-12 cells.	Emodin	80-83	microRNA 25	Rattus norvegicus	10-16
31257935-10	2019	Increased miR-25 was induced by EMO, and inhibited miR-25 abated the impacts of EMO on hypoxia-disposed PC-12 cells.	Emodin	80-83	microRNA 25	Rattus norvegicus	51-57
31257935-13	2019	The investigations corroborated that EMO weakened hypoxia-triggered injury via elevating miR-25 by targeting NEFL in PC-12 cells.	Emodin	37-40	microRNA 25	Rattus norvegicus	89-95
31257935-13	2019	The investigations corroborated that EMO weakened hypoxia-triggered injury via elevating miR-25 by targeting NEFL in PC-12 cells.	Emodin	37-40	neurofilament light chain	Rattus norvegicus	109-113
31731581-6	2019	In investigating the underlying mechanism, reporter assays indicated that emodin represses Zta promoter (Zp) and Rta promoter (Rp) activities, triggered by various inducers.	Emodin	74-80	RNA binding fox-1 homolog 2	Homo sapiens	113-116
31605249-5	2019	Emodin restored the pathological damage of SAP and simultaneously decreased the high levels of serum amylase, lipase, TNF-alpha, and IL-18 in the peripheral blood of SAP rat.	Emodin	0-6	lipase G, endothelial type	Rattus norvegicus	110-116
31605249-5	2019	Emodin restored the pathological damage of SAP and simultaneously decreased the high levels of serum amylase, lipase, TNF-alpha, and IL-18 in the peripheral blood of SAP rat.	Emodin	0-6	tumor necrosis factor	Rattus norvegicus	118-127
31605249-5	2019	Emodin restored the pathological damage of SAP and simultaneously decreased the high levels of serum amylase, lipase, TNF-alpha, and IL-18 in the peripheral blood of SAP rat.	Emodin	0-6	interleukin 18	Rattus norvegicus	133-138
31601256-11	2019	Western blot analysis proved that EMO promoted the relative expression of p-perk and p-eIF2alpha and that the expression of its downstream proteins CHOP and GRP78 was also enhanced.	Emodin	34-37	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	157-162
31601256-13	2019	In addition, histological and immunohistochemical analysis demonstrated that EMO functioned to inhibit epidural fibrosis and increase GRP78 expression in fibrous tissue by promoting apoptosis of fibroblasts.	Emodin	77-80	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	134-139
31572001-0	2019	Emodin sensitizes human pancreatic cancer cells to EGFR inhibitor through suppressing Stat3 signaling pathway.	Emodin	0-6	epidermal growth factor receptor	Homo sapiens	51-55
32186110-7	2019	RESULTS: Compared with the results for the dimethyl sulfoxide group, treatment of cells with TDA and emodin showed statistically significant differences in the FITC leakage rate, the apical / basolateral ratio of LDH and GGT, and the secretion of GGT, LDH, NAG and KIM-1.	Emodin	101-107	inactive glutathione hydrolase 2	Homo sapiens	221-224
32186110-7	2019	RESULTS: Compared with the results for the dimethyl sulfoxide group, treatment of cells with TDA and emodin showed statistically significant differences in the FITC leakage rate, the apical / basolateral ratio of LDH and GGT, and the secretion of GGT, LDH, NAG and KIM-1.	Emodin	101-107	inactive glutathione hydrolase 2	Homo sapiens	247-250
32186110-7	2019	RESULTS: Compared with the results for the dimethyl sulfoxide group, treatment of cells with TDA and emodin showed statistically significant differences in the FITC leakage rate, the apical / basolateral ratio of LDH and GGT, and the secretion of GGT, LDH, NAG and KIM-1.	Emodin	101-107	N-acetyl-alpha-glucosaminidase	Homo sapiens	257-260
32186110-7	2019	RESULTS: Compared with the results for the dimethyl sulfoxide group, treatment of cells with TDA and emodin showed statistically significant differences in the FITC leakage rate, the apical / basolateral ratio of LDH and GGT, and the secretion of GGT, LDH, NAG and KIM-1.	Emodin	101-107	hepatitis A virus cellular receptor 1	Homo sapiens	265-270
31572001-0	2019	Emodin sensitizes human pancreatic cancer cells to EGFR inhibitor through suppressing Stat3 signaling pathway.	Emodin	0-6	signal transducer and activator of transcription 3	Homo sapiens	86-91
31572001-8	2019	Results: Emodin remarkably enhanced the anti-cancer effect of EGFR inhibitor on pancreatic cancer cells.	Emodin	9-15	epidermal growth factor receptor	Homo sapiens	62-66
31572001-9	2019	In addition, emodin promoted afatinib-induced apoptosis by inhibiting the Stat3 signaling pathway.	Emodin	13-19	signal transducer and activator of transcription 3	Homo sapiens	74-79
31572001-13	2019	The tumor xenograft mice model was further confirmed that emodin possessed a synergy anticancer effect with afatinib on pancreatic cancer cells by regulating the Stat3 expression.	Emodin	58-64	signal transducer and activator of transcription 3	Mus musculus	162-167
31564833-0	2019	Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes.	Emodin	0-6	AKT serine/threonine kinase 1	Homo sapiens	65-68
31564833-0	2019	Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes.	Emodin	0-6	mechanistic target of rapamycin kinase	Homo sapiens	69-73
31564833-7	2019	In addition, emodin increased the number of GFP-LC3 puncta in L02 cells and upregulated the expression of LC3B-II compared to those in control cells.	Emodin	13-19	microtubule associated protein 1 light chain 3 beta	Homo sapiens	106-110
31564833-8	2019	Furthermore, emodin significantly decreased the expression of p-PI3K, p-AKT and p-mTOR in a dose-dependent manner compared to that in control cells without altering the expression of PI3K, AKT and mTOR.	Emodin	13-19	AKT serine/threonine kinase 1	Homo sapiens	72-75
31564833-8	2019	Furthermore, emodin significantly decreased the expression of p-PI3K, p-AKT and p-mTOR in a dose-dependent manner compared to that in control cells without altering the expression of PI3K, AKT and mTOR.	Emodin	13-19	mechanistic target of rapamycin kinase	Homo sapiens	82-86
31564833-10	2019	Conclusion:  In conclusion, emodin exhibited cytotoxicity in the L02 human hepatic cell line by promoting apoptosis, and it also induced autophagy through the suppression of the PI3K/AKT/mTOR signalling pathway.	Emodin	28-34	AKT serine/threonine kinase 1	Homo sapiens	183-186
31564833-10	2019	Conclusion:  In conclusion, emodin exhibited cytotoxicity in the L02 human hepatic cell line by promoting apoptosis, and it also induced autophagy through the suppression of the PI3K/AKT/mTOR signalling pathway.	Emodin	28-34	mechanistic target of rapamycin kinase	Homo sapiens	187-191
31114158-9	2019	In addition, we found that emodin significantly enhanced PTX-induced apoptosis in A549 cells via increasing the expressions of Bax and active caspase 3 and decreasing the levels of Bcl-2, p-Akt and p-ERK.	Emodin	27-33	caspase 3	Homo sapiens	142-151
31280208-0	2019	Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway.	Emodin	25-31	peroxiredoxin 5	Homo sapiens	0-15
31280208-0	2019	Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway.	Emodin	25-31	BCL2 apoptosis regulator	Homo sapiens	82-86
31280208-4	2019	MATERIALS AND METHODS: Stably constructed Prx V knockdown, over-expression and mock AGS cells (a human gastric adenocarcinoma cell line) were used to study the effect of Prx V on emodin-induced apoptosis by western blotting, cell viability, apoptosis and ROS detection assays.	Emodin	179-185	peroxiredoxin 5	Homo sapiens	170-175
31280208-5	2019	RESULTS: Overexpression of Prx V significantly decreased emodin-induced cellular apoptosis and ROS levels compared to Mock and Prx V knockdown AGS cells.	Emodin	57-63	peroxiredoxin 5	Homo sapiens	27-32
31236404-11	2019	Survival analysis showed that LPAR6, C5, SSTR5, GPR68, and P2RY4 may be involved in the molecular mechanisms of emodin therapy for HCC.	Emodin	112-118	lysophosphatidic acid receptor 6	Homo sapiens	30-35
31236404-11	2019	Survival analysis showed that LPAR6, C5, SSTR5, GPR68, and P2RY4 may be involved in the molecular mechanisms of emodin therapy for HCC.	Emodin	112-118	somatostatin receptor 5	Homo sapiens	41-46
31236404-11	2019	Survival analysis showed that LPAR6, C5, SSTR5, GPR68, and P2RY4 may be involved in the molecular mechanisms of emodin therapy for HCC.	Emodin	112-118	G protein-coupled receptor 68	Homo sapiens	48-53
31236404-11	2019	Survival analysis showed that LPAR6, C5, SSTR5, GPR68, and P2RY4 may be involved in the molecular mechanisms of emodin therapy for HCC.	Emodin	112-118	pyrimidinergic receptor P2Y4	Homo sapiens	59-64
31236404-12	2019	A quantitative real-time PCR (qRT-PCR) assay showed that the mRNA levels of LPAR6, C5, SSTR5, GPR68, and P2RY4 were significantly decreased in HepG2 cells treated with emodin.	Emodin	168-174	lysophosphatidic acid receptor 6	Homo sapiens	76-81
31236404-12	2019	A quantitative real-time PCR (qRT-PCR) assay showed that the mRNA levels of LPAR6, C5, SSTR5, GPR68, and P2RY4 were significantly decreased in HepG2 cells treated with emodin.	Emodin	168-174	somatostatin receptor 5	Homo sapiens	87-92
31236404-12	2019	A quantitative real-time PCR (qRT-PCR) assay showed that the mRNA levels of LPAR6, C5, SSTR5, GPR68, and P2RY4 were significantly decreased in HepG2 cells treated with emodin.	Emodin	168-174	G protein-coupled receptor 68	Homo sapiens	94-99
31236404-12	2019	A quantitative real-time PCR (qRT-PCR) assay showed that the mRNA levels of LPAR6, C5, SSTR5, GPR68, and P2RY4 were significantly decreased in HepG2 cells treated with emodin.	Emodin	168-174	pyrimidinergic receptor P2Y4	Homo sapiens	105-110
31114158-9	2019	In addition, we found that emodin significantly enhanced PTX-induced apoptosis in A549 cells via increasing the expressions of Bax and active caspase 3 and decreasing the levels of Bcl-2, p-Akt and p-ERK.	Emodin	27-33	BCL2 associated X, apoptosis regulator	Homo sapiens	127-130
31114158-9	2019	In addition, we found that emodin significantly enhanced PTX-induced apoptosis in A549 cells via increasing the expressions of Bax and active caspase 3 and decreasing the levels of Bcl-2, p-Akt and p-ERK.	Emodin	27-33	BCL2 apoptosis regulator	Homo sapiens	181-186
31114158-9	2019	In addition, we found that emodin significantly enhanced PTX-induced apoptosis in A549 cells via increasing the expressions of Bax and active caspase 3 and decreasing the levels of Bcl-2, p-Akt and p-ERK.	Emodin	27-33	AKT serine/threonine kinase 1	Homo sapiens	190-193
31114158-9	2019	In addition, we found that emodin significantly enhanced PTX-induced apoptosis in A549 cells via increasing the expressions of Bax and active caspase 3 and decreasing the levels of Bcl-2, p-Akt and p-ERK.	Emodin	27-33	mitogen-activated protein kinase 1	Homo sapiens	200-203
30407508-7	2019	Although it did not reduce the plasma homocysteine level, emodin (especially 80 mg/kg/d) reduced the levels of beta-amyloid and tau phosphorylation, decreased the levels of beta-site amyloid precursor protein-cleaving enzyme 1, and improved the activity of protein phosphatase 2A.	Emodin	58-64	beta-secretase 1	Rattus norvegicus	173-226
30741991-9	2019	In conclusion, EEC and EMO functionally express the mechanosensitive PIEZO1 channel that could act as a potential target for the development of novel treatments to further improve successful implantation processes.	Emodin	23-26	piezo type mechanosensitive ion channel component 1	Homo sapiens	69-75
30370860-12	2019	We also observed that both compounds up-regulated the p53 expression where Emodin causes nuclear p53 localization, which leads to down-regulation in mTOR expression and induces autophagy while Chrysophanol inhibits p53 translocation into nucleus, up-regulates mTOR expression and inhibits autophagy.	Emodin	75-81	tumor protein p53	Homo sapiens	54-57
30370860-12	2019	We also observed that both compounds up-regulated the p53 expression where Emodin causes nuclear p53 localization, which leads to down-regulation in mTOR expression and induces autophagy while Chrysophanol inhibits p53 translocation into nucleus, up-regulates mTOR expression and inhibits autophagy.	Emodin	75-81	tumor protein p53	Homo sapiens	97-100
30370860-12	2019	We also observed that both compounds up-regulated the p53 expression where Emodin causes nuclear p53 localization, which leads to down-regulation in mTOR expression and induces autophagy while Chrysophanol inhibits p53 translocation into nucleus, up-regulates mTOR expression and inhibits autophagy.	Emodin	75-81	mechanistic target of rapamycin kinase	Homo sapiens	149-153
30370860-12	2019	We also observed that both compounds up-regulated the p53 expression where Emodin causes nuclear p53 localization, which leads to down-regulation in mTOR expression and induces autophagy while Chrysophanol inhibits p53 translocation into nucleus, up-regulates mTOR expression and inhibits autophagy.	Emodin	75-81	tumor protein p53	Homo sapiens	97-100
30370860-12	2019	We also observed that both compounds up-regulated the p53 expression where Emodin causes nuclear p53 localization, which leads to down-regulation in mTOR expression and induces autophagy while Chrysophanol inhibits p53 translocation into nucleus, up-regulates mTOR expression and inhibits autophagy.	Emodin	75-81	mechanistic target of rapamycin kinase	Homo sapiens	260-264
31128032-9	2019	Furthermore, aloe emodin treatment led to a substantial enhancement of the conversion of light chain 3 (LC3)-l to LC3-ll and this increase was shown to follow aloe emodin dose-dependent pattern, thus indicating that aloe emodin may induce autophagy in addition to apoptosis.	Emodin	18-24	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	104-107
31128032-9	2019	Furthermore, aloe emodin treatment led to a substantial enhancement of the conversion of light chain 3 (LC3)-l to LC3-ll and this increase was shown to follow aloe emodin dose-dependent pattern, thus indicating that aloe emodin may induce autophagy in addition to apoptosis.	Emodin	18-24	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	114-117
30987561-8	2019	The molecular docking data showed that emodin could bind tightly to the active site of ADA.	Emodin	39-45	adenosine deaminase	Homo sapiens	87-90
30987561-9	2019	Our results demonstrated that emodin displayed a new biological activity which is ADA inhibitory activity with high cytotoxic activity against K562 leukemia cells.	Emodin	30-36	adenosine deaminase	Homo sapiens	82-85
30407508-10	2019	Lastly, hyperhomocysteinemia-induced microangiopathic alterations, oxidative stress, and elevated DNA methyltransferases 1 and 3beta were rescued by emodin.	Emodin	149-155	DNA methyltransferase 1	Rattus norvegicus	98-132
29121121-5	2017	Moreover, when incubated with emodin under different conditions where P-gp was inhibited, K562/ADM cells displayed increasing intracellular uptake of emodin, suggesting that emodin may be the potential substrate of P-gp.	Emodin	30-36	ATP binding cassette subfamily B member 1	Homo sapiens	70-74
30248416-3	2018	In toxicokinetics-toxicodynamics (TK-TD) study, aspartate aminotransferase (AST) and systemic exposure (area under the serum concentration-time curve, AUC) of emodin and its glucuronide were significantly increased in rats after co-administrated with emodin and probenecid for 28 consecutive days.	Emodin	159-165	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	48-74
30248416-5	2018	In addition, AUC of emodin glucuronide was increased 5-fold, which was attributed to the decrease of multidrug-resistant-protein 2 (MRP2) protein levels (decreased by 54.4%).	Emodin	20-26	ATP binding cassette subfamily C member 2	Rattus norvegicus	101-130
30248416-5	2018	In addition, AUC of emodin glucuronide was increased 5-fold, which was attributed to the decrease of multidrug-resistant-protein 2 (MRP2) protein levels (decreased by 54.4%).	Emodin	20-26	ATP binding cassette subfamily C member 2	Rattus norvegicus	132-136
30248416-7	2018	Our findings demonstrated that emodin-induced hepatoxicity was exacerbated by probenecid through inhibition of UGTs and MRP2 in vivo and in vitro, indicating that gout patients should avoid taking emodin-containing preparations in combination with probenecid for a long time.	Emodin	31-37	ATP binding cassette subfamily C member 2	Homo sapiens	120-124
30066878-11	2018	The expression levels of TGF-beta1, Snail family transcriptional repressor (Snail) 2, Snail, twist-related protein 1 and zinc finger E-box-binding homeobox (ZEB)1 and 2 mRNA were significantly decreased in emodin-treated groups compared with the untreated control.	Emodin	206-212	transforming growth factor, beta 1	Rattus norvegicus	25-34
30066878-11	2018	The expression levels of TGF-beta1, Snail family transcriptional repressor (Snail) 2, Snail, twist-related protein 1 and zinc finger E-box-binding homeobox (ZEB)1 and 2 mRNA were significantly decreased in emodin-treated groups compared with the untreated control.	Emodin	206-212	twist family bHLH transcription factor 1	Rattus norvegicus	93-116
30066878-11	2018	The expression levels of TGF-beta1, Snail family transcriptional repressor (Snail) 2, Snail, twist-related protein 1 and zinc finger E-box-binding homeobox (ZEB)1 and 2 mRNA were significantly decreased in emodin-treated groups compared with the untreated control.	Emodin	206-212	zinc finger E-box binding homeobox 1	Rattus norvegicus	157-168
29912852-10	2018	The transcript levels of LC3B, beclin-1, and p62 were decreased in the emodin-treated rats compared with non-emodin-treated rats.	Emodin	71-77	beclin 1	Rattus norvegicus	31-39
29912852-10	2018	The transcript levels of LC3B, beclin-1, and p62 were decreased in the emodin-treated rats compared with non-emodin-treated rats.	Emodin	71-77	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	45-48
29398130-1	2018	In previous studies, sonodynamic therapy mediated by emodin (emodin-SDT) induced cytoskeletal filament disruption and apoptosis of THP-1-derived macrophages.	Emodin	53-59	GLI family zinc finger 2	Homo sapiens	131-136
29644529-8	2018	The results presented in this study raise the hypothesis that higher production of LRP1 protein may be associated with higher endocytosis of upregulated transporter proteins at the cell surface, and hence, increased dox and emodin accumulation and growth inhibition.	Emodin	224-230	LDL receptor related protein 1	Homo sapiens	83-87
30117601-1	2018	The aim of this study was to evaluate the hypothesis that emodin inhibits extracellular matrix (ECM)-related gene expression in activated hepatic stellate cells (HSCs) by blocking canonical or/and noncanonical components of transforming growth factor beta1 (TGFbeta1) intracellular signaling.	Emodin	58-64	transforming growth factor, beta 1	Rattus norvegicus	224-256
30117601-1	2018	The aim of this study was to evaluate the hypothesis that emodin inhibits extracellular matrix (ECM)-related gene expression in activated hepatic stellate cells (HSCs) by blocking canonical or/and noncanonical components of transforming growth factor beta1 (TGFbeta1) intracellular signaling.	Emodin	58-64	transforming growth factor, beta 1	Rattus norvegicus	258-266
30011215-7	2018	A genome-wide association study (GWAS) identified that rs11726899 located within ~50 kb of the transcript of UGT2B could significantly affect emodin metabolism.	Emodin	142-148	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	109-114
29355754-7	2018	We went on to study the effect of blocking protein aggregation by emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) and figured that inhibiting p53 protein aggregation can elevate the level of autophagy in A549 lung cancer cell line while there is no significant effect on autophagy in normal non-cancerous HaCaT cells.	Emodin	74-113	tumor protein p53	Homo sapiens	143-146
29121121-5	2017	Moreover, when incubated with emodin under different conditions where P-gp was inhibited, K562/ADM cells displayed increasing intracellular uptake of emodin, suggesting that emodin may be the potential substrate of P-gp.	Emodin	30-36	ATP binding cassette subfamily B member 1	Homo sapiens	215-219
29121121-5	2017	Moreover, when incubated with emodin under different conditions where P-gp was inhibited, K562/ADM cells displayed increasing intracellular uptake of emodin, suggesting that emodin may be the potential substrate of P-gp.	Emodin	150-156	ATP binding cassette subfamily B member 1	Homo sapiens	70-74
29121121-5	2017	Moreover, when incubated with emodin under different conditions where P-gp was inhibited, K562/ADM cells displayed increasing intracellular uptake of emodin, suggesting that emodin may be the potential substrate of P-gp.	Emodin	150-156	ATP binding cassette subfamily B member 1	Homo sapiens	215-219
31966818-0	2017	Emodin inhibits the proliferation and invasion of bladder cancer cells via down-regulating Notch1.	Emodin	0-6	notch receptor 1	Homo sapiens	91-97
31966486-0	2017	Emodin inhibits the expression of receptor and calcitonin-gene-related peptide release in trigeminal ganglia of trigeminal neuralgia rats.	Emodin	0-6	calcitonin-related polypeptide alpha	Rattus norvegicus	47-78
31966486-3	2017	The present study investigated whether emodin can affect TN pain transmission by suppressing the expression of P2X3 receptors and CGRP in TGs.	Emodin	39-45	calcitonin-related polypeptide alpha	Rattus norvegicus	130-134
31966486-11	2017	However after treatment with emodin, the response of mechanical hyperalgesia of TN rats was clearly increased while the enhanced expression of P2X3 receptor and CGRP in TN rats was significantly decreased.	Emodin	29-35	calcitonin-related polypeptide alpha	Rattus norvegicus	161-165
31966486-14	2017	In conclusion, P2X3 receptor may cooperate with CGRP in the pain transmission of TN, and emodin can inhibit the expression and activation of P2X3 receptor and CGRP in TG to relieve TN.	Emodin	89-95	calcitonin-related polypeptide alpha	Rattus norvegicus	159-163
31966818-5	2017	Emodin repressed cell growth, invasion and Notch1 expression in a concentration-dependent fashion.	Emodin	0-6	notch receptor 1	Homo sapiens	43-49
31966818-6	2017	And Notch1 over-expression assay showed that the anti-proliferative and anti-invasive roles of emodin, along with the down-regulated effects on the expression of Notch1, Jagged1, VEGF, VEGFR2 and MMP2 were partially rescued by Notch1 over-expression.	Emodin	95-101	notch receptor 1	Homo sapiens	4-10
31966818-6	2017	And Notch1 over-expression assay showed that the anti-proliferative and anti-invasive roles of emodin, along with the down-regulated effects on the expression of Notch1, Jagged1, VEGF, VEGFR2 and MMP2 were partially rescued by Notch1 over-expression.	Emodin	95-101	notch receptor 1	Homo sapiens	162-168
31966818-6	2017	And Notch1 over-expression assay showed that the anti-proliferative and anti-invasive roles of emodin, along with the down-regulated effects on the expression of Notch1, Jagged1, VEGF, VEGFR2 and MMP2 were partially rescued by Notch1 over-expression.	Emodin	95-101	jagged canonical Notch ligand 1	Homo sapiens	170-177
31966818-6	2017	And Notch1 over-expression assay showed that the anti-proliferative and anti-invasive roles of emodin, along with the down-regulated effects on the expression of Notch1, Jagged1, VEGF, VEGFR2 and MMP2 were partially rescued by Notch1 over-expression.	Emodin	95-101	vascular endothelial growth factor A	Homo sapiens	179-183
31966818-6	2017	And Notch1 over-expression assay showed that the anti-proliferative and anti-invasive roles of emodin, along with the down-regulated effects on the expression of Notch1, Jagged1, VEGF, VEGFR2 and MMP2 were partially rescued by Notch1 over-expression.	Emodin	95-101	kinase insert domain receptor	Homo sapiens	185-191
31966818-6	2017	And Notch1 over-expression assay showed that the anti-proliferative and anti-invasive roles of emodin, along with the down-regulated effects on the expression of Notch1, Jagged1, VEGF, VEGFR2 and MMP2 were partially rescued by Notch1 over-expression.	Emodin	95-101	matrix metallopeptidase 2	Homo sapiens	196-200
31966818-6	2017	And Notch1 over-expression assay showed that the anti-proliferative and anti-invasive roles of emodin, along with the down-regulated effects on the expression of Notch1, Jagged1, VEGF, VEGFR2 and MMP2 were partially rescued by Notch1 over-expression.	Emodin	95-101	notch receptor 1	Homo sapiens	162-168
31966818-7	2017	In conclusion, Emodin might suppress the progression of bladder cancer via inhibiting the expression of Notch1.	Emodin	15-21	notch receptor 1	Homo sapiens	104-110
27427516-3	2016	We describe a unique survivin-associated adaptive response in which increased radiation resistance or sensitization of cells can be induced by exposure to 5mGy or to the reactive oxygen species (ROS) generating drug Emodin (1,3,8-trihydroxy-6-methylanthraquinone), a naturally occurring anthraquinone.	Emodin	216-222	baculoviral IAP repeat-containing 5	Mus musculus	21-29
28214826-17	2017	On the contrary, overexpressed IGFBP1 enhanced emodin-induced phosphorylation of AMPKalpha and ERK1/2, and restored emodin-inhibited growth in cells with silenced endogenous IGFBP1 gene.	Emodin	47-53	insulin like growth factor binding protein 1	Homo sapiens	31-37
28214826-17	2017	On the contrary, overexpressed IGFBP1 enhanced emodin-induced phosphorylation of AMPKalpha and ERK1/2, and restored emodin-inhibited growth in cells with silenced endogenous IGFBP1 gene.	Emodin	47-53	mitogen-activated protein kinase 3	Homo sapiens	95-101
28214826-17	2017	On the contrary, overexpressed IGFBP1 enhanced emodin-induced phosphorylation of AMPKalpha and ERK1/2, and restored emodin-inhibited growth in cells with silenced endogenous IGFBP1 gene.	Emodin	47-53	insulin like growth factor binding protein 1	Homo sapiens	174-180
28214826-17	2017	On the contrary, overexpressed IGFBP1 enhanced emodin-induced phosphorylation of AMPKalpha and ERK1/2, and restored emodin-inhibited growth in cells with silenced endogenous IGFBP1 gene.	Emodin	116-122	insulin like growth factor binding protein 1	Homo sapiens	31-37
27427516-3	2016	We describe a unique survivin-associated adaptive response in which increased radiation resistance or sensitization of cells can be induced by exposure to 5mGy or to the reactive oxygen species (ROS) generating drug Emodin (1,3,8-trihydroxy-6-methylanthraquinone), a naturally occurring anthraquinone.	Emodin	224-262	baculoviral IAP repeat-containing 5	Mus musculus	21-29
27485374-11	2016	Consistent with in vitro experiments, emodin/cisplatin co-treatment increased the cell apoptosis and repressed the MRP1 expression in xenograft tumors, and without obvious systemic toxicity.	Emodin	38-44	ATP binding cassette subfamily C member 1	Homo sapiens	115-119
27507206-5	2016	The results showed that ginkgolic acid (GA) (13 : 0), GA (15 : 1), GA (17 : 1), erythrosine B, silibinin, and emodin have inhibitory effects on NTCP uptake of TCNa in a concentration-dependent manner.	Emodin	110-116	solute carrier family 10 member 1	Homo sapiens	144-148
28875685-8	2016	Network pharmacology analysis using ingenuity pathway analysis (IPA) software revealed that TCM-derived drugs interacting with AMPK target proteins included berberine, emodin, curcumin, resveratrol, alcohol, cordyceps, arctiin, suggesting in a certain extent the feasibility of "medicine -food homology" drugs to extend the lifespan through the AMPK pathway.	Emodin	168-174	AMP-activated protein kinase alpha subunit	Drosophila melanogaster	127-131
26149242-2	2015	Cytotoxicity tests demonstrated a dose-dependent toxic effect of emodin, triptolide, and aristolochic acid on HL7702 cells for 48 h. Emodin (14 muM), aristolochic acid (12 mug/mL), or triptolide (18 nM) was individually administrated to HL7702 and cell samples were collected after 48 h for metabolites extraction and analysis.	Emodin	133-139	latexin	Homo sapiens	144-147
25948190-7	2015	The combination of emodin and AZT had considerable synergistic inhibitory effects on proliferation of normal KG-1a cells and nonspecific control(KG-1a NC) cells, but the synergistic effects disappeared after Egr-1 gene silencing.	Emodin	19-25	early growth response 1	Homo sapiens	208-213
25889897-6	2015	Interestingly, the inhibitor of MAPK extracellular signaling-regulated kinase (ERK) kinase (MEK)/ERK1/2 (PD98059) attenuated emodin-induced phosphorylation of AMPKalpha.	Emodin	125-131	mitogen-activated protein kinase kinase 7	Homo sapiens	92-95
25889897-6	2015	Interestingly, the inhibitor of MAPK extracellular signaling-regulated kinase (ERK) kinase (MEK)/ERK1/2 (PD98059) attenuated emodin-induced phosphorylation of AMPKalpha.	Emodin	125-131	mitogen-activated protein kinase 3	Homo sapiens	97-103
25634255-6	2015	Furthermore, treatment with emodin (40 mg/ml) markedly inhibited phosphoinositide 3-kinase (PI3K)/Akt activity (P<0.01) and this attenuation was associated with reduced expression levels of tumor necrosis factor-alpha, interleukin-6 and monocyte chemoattractant protein-1 (P<0.05) in the HS tissue.	Emodin	28-34	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	65-90
25634255-6	2015	Furthermore, treatment with emodin (40 mg/ml) markedly inhibited phosphoinositide 3-kinase (PI3K)/Akt activity (P<0.01) and this attenuation was associated with reduced expression levels of tumor necrosis factor-alpha, interleukin-6 and monocyte chemoattractant protein-1 (P<0.05) in the HS tissue.	Emodin	28-34	thymoma viral proto-oncogene 1	Mus musculus	98-101
25634255-6	2015	Furthermore, treatment with emodin (40 mg/ml) markedly inhibited phosphoinositide 3-kinase (PI3K)/Akt activity (P<0.01) and this attenuation was associated with reduced expression levels of tumor necrosis factor-alpha, interleukin-6 and monocyte chemoattractant protein-1 (P<0.05) in the HS tissue.	Emodin	28-34	tumor necrosis factor	Mus musculus	193-220
25634255-6	2015	Furthermore, treatment with emodin (40 mg/ml) markedly inhibited phosphoinositide 3-kinase (PI3K)/Akt activity (P<0.01) and this attenuation was associated with reduced expression levels of tumor necrosis factor-alpha, interleukin-6 and monocyte chemoattractant protein-1 (P<0.05) in the HS tissue.	Emodin	28-34	interleukin 6	Mus musculus	222-235
25634255-6	2015	Furthermore, treatment with emodin (40 mg/ml) markedly inhibited phosphoinositide 3-kinase (PI3K)/Akt activity (P<0.01) and this attenuation was associated with reduced expression levels of tumor necrosis factor-alpha, interleukin-6 and monocyte chemoattractant protein-1 (P<0.05) in the HS tissue.	Emodin	28-34	chemokine (C-C motif) ligand 2	Mus musculus	240-274
25590369-0	2015	Blockade of emodin on amyloid-beta 25-35-induced neurotoxicity in AbetaPP/PS1 mice and PC12 cells through activation of the class III phosphatidylinositol 3-kinase/Beclin-1/B-cell lymphoma 2 pathway.	Emodin	12-18	amyloid beta (A4) precursor protein	Mus musculus	66-73
25590369-0	2015	Blockade of emodin on amyloid-beta 25-35-induced neurotoxicity in AbetaPP/PS1 mice and PC12 cells through activation of the class III phosphatidylinositol 3-kinase/Beclin-1/B-cell lymphoma 2 pathway.	Emodin	12-18	presenilin 1	Mus musculus	74-77
25590369-0	2015	Blockade of emodin on amyloid-beta 25-35-induced neurotoxicity in AbetaPP/PS1 mice and PC12 cells through activation of the class III phosphatidylinositol 3-kinase/Beclin-1/B-cell lymphoma 2 pathway.	Emodin	12-18	beclin 1	Rattus norvegicus	164-172
25590369-5	2015	AbetaPP/PS1 mice were administered orally with emodin (50 mg/kg/day), and LC3-II positive cells in their brain cortex sections were detected by immunohistochemical staining.	Emodin	47-53	amyloid beta (A4) precursor protein	Mus musculus	0-7
25590369-6	2015	Emodin could significantly inhibit the LC3-I/LC3-II conversion ratio and cell viability while decreasing the lactate dehydrogenase level in AbetaPP/PS1 mice and PC12 cells.	Emodin	0-6	annexin A3	Rattus norvegicus	39-42
25590369-6	2015	Emodin could significantly inhibit the LC3-I/LC3-II conversion ratio and cell viability while decreasing the lactate dehydrogenase level in AbetaPP/PS1 mice and PC12 cells.	Emodin	0-6	annexin A3	Rattus norvegicus	45-48
25590369-6	2015	Emodin could significantly inhibit the LC3-I/LC3-II conversion ratio and cell viability while decreasing the lactate dehydrogenase level in AbetaPP/PS1 mice and PC12 cells.	Emodin	0-6	amyloid beta (A4) precursor protein	Mus musculus	140-147
25590369-6	2015	Emodin could significantly inhibit the LC3-I/LC3-II conversion ratio and cell viability while decreasing the lactate dehydrogenase level in AbetaPP/PS1 mice and PC12 cells.	Emodin	0-6	presenilin 1	Mus musculus	148-151
25590369-7	2015	LC3II positive cells in the cortex were decreased significantly by the treatment with both emodin and 3-methyladenine.	Emodin	91-97	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	0-5
25590369-8	2015	Furthermore, emodin and 3-methyladenine could increase B-cell lymphoma 2 while decreasing Beclin-1 and hVps34 expressions, which were induced by amyloid-beta 25-35.	Emodin	13-19	beclin 1	Rattus norvegicus	90-98
25590369-8	2015	Furthermore, emodin and 3-methyladenine could increase B-cell lymphoma 2 while decreasing Beclin-1 and hVps34 expressions, which were induced by amyloid-beta 25-35.	Emodin	13-19	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	103-109
25590369-11	2015	The results suggest that the blockade of emodin on amyloid-beta 25-35-induced autophagy may occur via the activation of the class III phosphatidylinositol 3-kinase/Beclin-1/B-cell lymphoma 2 pathway.	Emodin	41-47	beclin 1	Rattus norvegicus	164-172
23796248-6	2013	RESULTS: Emodin, quercetin, and cis-stilbene were the most effective polyphenols at decreasing cell viability (IC50 values of 5-22 muM, 8-33 muM, and 25-85 muM respectively) and inducing apoptosis (AP50 values (the concentration which 50% of cells undergo apoptosis) of 2-27 muM, 19-50 muM, and 8-50 muM respectively).	Emodin	9-15	adaptor related protein complex 2 subunit mu 1	Homo sapiens	198-202
25205133-4	2014	Here we demonstrate that emodin (1,3,8-trihydroxy-6-methylanthraquinone), an anthraquinone present in the roots and bark of several medicinal plants, down regulates Wnt signaling pathway in human colorectal cancer cells (SW480 and SW620) by down regulating TCF/LEF transcriptional activity.	Emodin	25-31	hepatocyte nuclear factor 4 alpha	Homo sapiens	257-264
25205133-4	2014	Here we demonstrate that emodin (1,3,8-trihydroxy-6-methylanthraquinone), an anthraquinone present in the roots and bark of several medicinal plants, down regulates Wnt signaling pathway in human colorectal cancer cells (SW480 and SW620) by down regulating TCF/LEF transcriptional activity.	Emodin	33-71	hepatocyte nuclear factor 4 alpha	Homo sapiens	257-264
24909118-9	2014	Western blot analysis revealed that emodin inhibited phenylephrine-induced phospho-myosin light chain (pMLC) and the phosphorylation of myosin-targeting subunit and C-kinase-activated protein phosphatase-1 inhibitor (CPI-17).	Emodin	36-42	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	217-223
22038303-4	2013	A significant decline in Bcl2/Bax ratio consistent with the release of mitochondrial cytochrome c release in DL cells from emodin-treated DL mice suggested that emodin could induce mitochondrial pathway of apoptosis in the DL cells in vivo.	Emodin	123-129	B cell leukemia/lymphoma 2	Mus musculus	25-29
22974371-4	2013	We previously showed that 1,3,8-trihydroxy-6-methylanthraquinone (emodin), a reactive oxygen species (ROS) generator, enhanced sensitivity of gallbladder cancer SGC-996 cells to cisplatin (CDDP) via generation of ROS and downregulation of multidrug-resistance-associated protein 1 (MRP1).	Emodin	26-64	ATP binding cassette subfamily C member 1	Homo sapiens	239-280
24113589-5	2013	Pretreatment with nitric oxide (NO) scavengers suppressed the apoptotic biochemical changes induced by 20 muM emodin, and attenuated emodin-induced p53 and p21 expression involved in apoptotic signaling.	Emodin	110-116	latexin	Homo sapiens	106-109
23811723-11	2013	Furthermore, emodin significantly increased the levels of ROS and MDA, inhibited both SOD level and GSH/GSSG ratio in human T cells, whereas co-incubation with the ROS scavenger N-acetylcysteine (NAC, 20 mumol/L) almost completely blocked emodin-induced ER stress and mitochondrial dysfunction in human T cells, and decreased the caspase cascade-mediated apoptosis.	Emodin	13-19	superoxide dismutase 1	Homo sapiens	86-89
24325094-9	2013	Increased proliferation levels of the Ad-PML (NLS-) infected HL-60 cells were observed in those treated with 60 pmol/L emodin, which showed decreased percentage of cells at Gx phase, increased percentage of cells at S phase, and decreased emodin-induced apoptosis.	Emodin	119-125	PML nuclear body scaffold	Homo sapiens	41-44
22974371-4	2013	We previously showed that 1,3,8-trihydroxy-6-methylanthraquinone (emodin), a reactive oxygen species (ROS) generator, enhanced sensitivity of gallbladder cancer SGC-996 cells to cisplatin (CDDP) via generation of ROS and downregulation of multidrug-resistance-associated protein 1 (MRP1).	Emodin	26-64	ATP binding cassette subfamily C member 1	Homo sapiens	282-286
22974371-4	2013	We previously showed that 1,3,8-trihydroxy-6-methylanthraquinone (emodin), a reactive oxygen species (ROS) generator, enhanced sensitivity of gallbladder cancer SGC-996 cells to cisplatin (CDDP) via generation of ROS and downregulation of multidrug-resistance-associated protein 1 (MRP1).	Emodin	66-72	ATP binding cassette subfamily C member 1	Homo sapiens	239-280
22974371-4	2013	We previously showed that 1,3,8-trihydroxy-6-methylanthraquinone (emodin), a reactive oxygen species (ROS) generator, enhanced sensitivity of gallbladder cancer SGC-996 cells to cisplatin (CDDP) via generation of ROS and downregulation of multidrug-resistance-associated protein 1 (MRP1).	Emodin	66-72	ATP binding cassette subfamily C member 1	Homo sapiens	282-286
22565822-6	2013	Furthermore, emodin increased the protein level of p53 and decreased the protein level of NF-kappaB/p65 in HepG2 cells, which indicated these two regulators might play a role in emodin-induced apoptosis.	Emodin	13-19	tumor protein p53	Homo sapiens	51-54
22565822-6	2013	Furthermore, emodin increased the protein level of p53 and decreased the protein level of NF-kappaB/p65 in HepG2 cells, which indicated these two regulators might play a role in emodin-induced apoptosis.	Emodin	13-19	RELA proto-oncogene, NF-kB subunit	Homo sapiens	100-103
23661994-8	2013	The order of affinity of other ligands with p105 was found as follows: guggulsterone > sylibinin > emodin > resveratrol > genistein > boswellic acid > ellagic acid.	Emodin	105-111	nuclear factor kappa B subunit 1	Homo sapiens	44-48
32289000-8	2012	The overall molecular mechanisms of emodin include cell cycle arrest, apoptosis, and the promotion of the expression of hypoxia-inducible factor 1alpha, glutathione S-transferase P, N-acetyltransferase, and glutathione phase I and II detoxification enzymes while inhibiting angiogenesis, invasion, migration, chemical-induced carcinogen-DNA adduct formation, HER2/neu, CKII kinase, and p34cdc2 kinase in human cancer cells.	Emodin	36-42	erb-b2 receptor tyrosine kinase 2	Homo sapiens	359-363
22299827-9	2012	Overall, our findings suggest that ED is a novel blocker of CXCR4 expression and, thus, has enormous potential as a powerful therapeutic agent for metastatic cancer.	Emodin	35-37	C-X-C motif chemokine receptor 4	Homo sapiens	60-65
22922341-1	2012	AIM: Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a potent and selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) with the ability to ameliorate metabolic disorders in diet-induced obese mice.	Emodin	5-11	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	92-134
22922341-1	2012	AIM: Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a potent and selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) with the ability to ameliorate metabolic disorders in diet-induced obese mice.	Emodin	5-11	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	136-147
22922341-1	2012	AIM: Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a potent and selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) with the ability to ameliorate metabolic disorders in diet-induced obese mice.	Emodin	13-51	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	92-134
22922341-1	2012	AIM: Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a potent and selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) with the ability to ameliorate metabolic disorders in diet-induced obese mice.	Emodin	13-51	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	136-147
32289000-8	2012	The overall molecular mechanisms of emodin include cell cycle arrest, apoptosis, and the promotion of the expression of hypoxia-inducible factor 1alpha, glutathione S-transferase P, N-acetyltransferase, and glutathione phase I and II detoxification enzymes while inhibiting angiogenesis, invasion, migration, chemical-induced carcinogen-DNA adduct formation, HER2/neu, CKII kinase, and p34cdc2 kinase in human cancer cells.	Emodin	36-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-151
32289000-8	2012	The overall molecular mechanisms of emodin include cell cycle arrest, apoptosis, and the promotion of the expression of hypoxia-inducible factor 1alpha, glutathione S-transferase P, N-acetyltransferase, and glutathione phase I and II detoxification enzymes while inhibiting angiogenesis, invasion, migration, chemical-induced carcinogen-DNA adduct formation, HER2/neu, CKII kinase, and p34cdc2 kinase in human cancer cells.	Emodin	36-42	erb-b2 receptor tyrosine kinase 2	Homo sapiens	364-367
21866366-5	2011	In the present study, we demonstrated the role of exogenous NO levels in the regulation of MMP2 and MMP9 (gelatinases A and B) in colon cancer cell line WiDr and its inhibition with emodin (a naturally occurring anthraquinone).	Emodin	182-188	matrix metallopeptidase 2	Homo sapiens	91-95
21866366-5	2011	In the present study, we demonstrated the role of exogenous NO levels in the regulation of MMP2 and MMP9 (gelatinases A and B) in colon cancer cell line WiDr and its inhibition with emodin (a naturally occurring anthraquinone).	Emodin	182-188	matrix metallopeptidase 9	Homo sapiens	100-104
20230058-6	2010	Four compounds (emodin, emodin-8-O-beta-D-glucopyranoside, (+)-catechin, and (-)-epicatechin) isolated from EP were identified as ACC inhibitors.	Emodin	16-22	acetyl-CoA carboxylase alpha	Homo sapiens	130-133
21524190-7	2011	In addition, both mycophenolic acid (substrate of UGT1A9) and emodin (substrate of UGT1A8 and UGT1A10) could inhibit the glucuronidation of Picroside II with the half maximal inhibitory concentration (IC(50)) values of 173.6 and 76.2 muM, respectively.	Emodin	62-68	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	83-89
21524190-7	2011	In addition, both mycophenolic acid (substrate of UGT1A9) and emodin (substrate of UGT1A8 and UGT1A10) could inhibit the glucuronidation of Picroside II with the half maximal inhibitory concentration (IC(50)) values of 173.6 and 76.2 muM, respectively.	Emodin	62-68	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	94-101
21524190-7	2011	In addition, both mycophenolic acid (substrate of UGT1A9) and emodin (substrate of UGT1A8 and UGT1A10) could inhibit the glucuronidation of Picroside II with the half maximal inhibitory concentration (IC(50)) values of 173.6 and 76.2 muM, respectively.	Emodin	62-68	latexin	Homo sapiens	234-237
21382473-3	2011	Hypoxic conditions induced various developmental anomalies in the growth stages and remarkably low levels of HIF-1alpha, SOD1 and SOD2 mRNAs, and SOD activity in the embryos; however, these effects were significantly reversed by treatment with emodin, [6]-gingerol, and MnTBAP, respectively.	Emodin	244-250	hypoxia inducible factor 1, alpha subunit	Mus musculus	109-119
21168393-8	2011	Enhancement of ERK1/2 signaling by constitutively active MKK1/2 (MKK1/2-CA) results in increasing Rad51 and ERCC1 protein levels and cell viability in NSCLC cell lines treated with emodin and capecitabine.	Emodin	181-187	mitogen-activated protein kinase 3	Homo sapiens	15-21
21168393-8	2011	Enhancement of ERK1/2 signaling by constitutively active MKK1/2 (MKK1/2-CA) results in increasing Rad51 and ERCC1 protein levels and cell viability in NSCLC cell lines treated with emodin and capecitabine.	Emodin	181-187	mitogen-activated protein kinase kinase 1	Homo sapiens	57-63
21168393-8	2011	Enhancement of ERK1/2 signaling by constitutively active MKK1/2 (MKK1/2-CA) results in increasing Rad51 and ERCC1 protein levels and cell viability in NSCLC cell lines treated with emodin and capecitabine.	Emodin	181-187	mitogen-activated protein kinase kinase 1	Homo sapiens	65-74
21168393-8	2011	Enhancement of ERK1/2 signaling by constitutively active MKK1/2 (MKK1/2-CA) results in increasing Rad51 and ERCC1 protein levels and cell viability in NSCLC cell lines treated with emodin and capecitabine.	Emodin	181-187	RAD51 recombinase	Homo sapiens	98-103
21168393-8	2011	Enhancement of ERK1/2 signaling by constitutively active MKK1/2 (MKK1/2-CA) results in increasing Rad51 and ERCC1 protein levels and cell viability in NSCLC cell lines treated with emodin and capecitabine.	Emodin	181-187	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	108-113
19962780-8	2010	Enhancement of ERK1/2 activation by transfection with constitutively active MKK1/2 (MKK1/2-CA) vector increased ERCC1 protein levels and protein stability, as well as increasing viability of NSCLC cells treated with emodin and cisplatin.	Emodin	216-222	mitogen-activated protein kinase 3	Homo sapiens	15-21
19962780-8	2010	Enhancement of ERK1/2 activation by transfection with constitutively active MKK1/2 (MKK1/2-CA) vector increased ERCC1 protein levels and protein stability, as well as increasing viability of NSCLC cells treated with emodin and cisplatin.	Emodin	216-222	mitogen-activated protein kinase kinase 1	Homo sapiens	76-82
19962780-8	2010	Enhancement of ERK1/2 activation by transfection with constitutively active MKK1/2 (MKK1/2-CA) vector increased ERCC1 protein levels and protein stability, as well as increasing viability of NSCLC cells treated with emodin and cisplatin.	Emodin	216-222	mitogen-activated protein kinase kinase 1	Homo sapiens	84-93
21319176-1	2011	Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a herbal medicine extracted from the rhizomes of Rheum palmatum, and is known as an inhibitor of casein kinase II (CK2).	Emodin	0-6	casein kinase 2, alpha prime polypeptide	Mus musculus	167-170
21319176-1	2011	Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a herbal medicine extracted from the rhizomes of Rheum palmatum, and is known as an inhibitor of casein kinase II (CK2).	Emodin	8-47	casein kinase 2, alpha prime polypeptide	Mus musculus	167-170
21442678-7	2011	Taken together, these findings suggest that rhubarb exerts inhibitory activity against AD, and that the 5-LOX inhibitory activity of its major constituent, emodin, may contribute to this inhibitory action.	Emodin	156-162	arachidonate 5-lipoxygenase	Rattus norvegicus	104-109
20863847-2	2010	Previously, we found that the anthraquinone derivative emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits ErbB1 signaling and ameliorates behavioral deficits of the schizophrenia animal model established by EGF challenge.	Emodin	55-61	epidermal growth factor receptor	Rattus norvegicus	112-117
20863847-2	2010	Previously, we found that the anthraquinone derivative emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits ErbB1 signaling and ameliorates behavioral deficits of the schizophrenia animal model established by EGF challenge.	Emodin	55-61	epidermal growth factor like 1	Rattus norvegicus	213-216
20863847-2	2010	Previously, we found that the anthraquinone derivative emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits ErbB1 signaling and ameliorates behavioral deficits of the schizophrenia animal model established by EGF challenge.	Emodin	63-101	epidermal growth factor receptor	Rattus norvegicus	112-117
20863847-2	2010	Previously, we found that the anthraquinone derivative emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits ErbB1 signaling and ameliorates behavioral deficits of the schizophrenia animal model established by EGF challenge.	Emodin	63-101	epidermal growth factor like 1	Rattus norvegicus	213-216
19895793-6	2010	Cell cycle regulatory gene analysis showed increased protein levels of cyclin A, cyclin B, Chk2, Cdk2, and P27 in hepatoma cells after time courses of emodin treatment, and Western blot analysis showed decreased protein levels of Cdc25c and P21.	Emodin	151-157	cyclin A2	Homo sapiens	71-79
19895793-6	2010	Cell cycle regulatory gene analysis showed increased protein levels of cyclin A, cyclin B, Chk2, Cdk2, and P27 in hepatoma cells after time courses of emodin treatment, and Western blot analysis showed decreased protein levels of Cdc25c and P21.	Emodin	151-157	checkpoint kinase 2	Homo sapiens	91-95
19895793-6	2010	Cell cycle regulatory gene analysis showed increased protein levels of cyclin A, cyclin B, Chk2, Cdk2, and P27 in hepatoma cells after time courses of emodin treatment, and Western blot analysis showed decreased protein levels of Cdc25c and P21.	Emodin	151-157	cyclin dependent kinase 2	Homo sapiens	97-101
19895793-6	2010	Cell cycle regulatory gene analysis showed increased protein levels of cyclin A, cyclin B, Chk2, Cdk2, and P27 in hepatoma cells after time courses of emodin treatment, and Western blot analysis showed decreased protein levels of Cdc25c and P21.	Emodin	151-157	interferon alpha inducible protein 27	Homo sapiens	107-110
19895793-6	2010	Cell cycle regulatory gene analysis showed increased protein levels of cyclin A, cyclin B, Chk2, Cdk2, and P27 in hepatoma cells after time courses of emodin treatment, and Western blot analysis showed decreased protein levels of Cdc25c and P21.	Emodin	151-157	cell division cycle 25C	Homo sapiens	230-236
19895793-6	2010	Cell cycle regulatory gene analysis showed increased protein levels of cyclin A, cyclin B, Chk2, Cdk2, and P27 in hepatoma cells after time courses of emodin treatment, and Western blot analysis showed decreased protein levels of Cdc25c and P21.	Emodin	151-157	H3 histone pseudogene 16	Homo sapiens	241-244
19549930-9	2009	C6 cells also expressed GRP78 to decrease emodin-induced endoplasmic reticulum (ER) stress that would cause apoptosis in C6 cells, and GRP78 inhibited the expression of GADD153 to enhance the expression of Bcl-2 that could balance the ER- and mitochondria-induced apoptosis of C6 cells.	Emodin	42-48	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	24-29
19432557-1	2009	Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a moderately potent and poorly selective inhibitor of protein kinase CK2, one of the most pleiotropic serine/threonine protein kinases, implicated in neoplasia and in other global diseases.	Emodin	0-6	casein kinase 2, alpha prime polypeptide	Mus musculus	121-124
19432557-1	2009	Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a moderately potent and poorly selective inhibitor of protein kinase CK2, one of the most pleiotropic serine/threonine protein kinases, implicated in neoplasia and in other global diseases.	Emodin	8-47	casein kinase 2, alpha prime polypeptide	Mus musculus	121-124
19432557-2	2009	By virtual screening of the MMS (Molecular Modeling Section) database, we have now identified quinalizarin (1,2,5,8-tetrahydroxyanthraquinone) as an inhibitor of CK2 that is more potent and selective than emodin.	Emodin	205-211	casein kinase 2, alpha prime polypeptide	Mus musculus	162-165
19152226-2	2009	Here, we report that the natural anthraquinones, emodin, emodic acid, chrysazin, physcion, and rhein differentially inhibit several members of this enzyme family, the gelatinases MMP-2 and -9, and the collagenase MMP-13.	Emodin	49-55	matrix metallopeptidase 2	Homo sapiens	179-191
19389047-7	2009	By comparison, the administration of emodin and chrysophanol did not reduce the serum levels of hepatic enzymes glutamate-pyruvate transaminase and glutamic oxaloacetic transaminase but decreased the levels of serum total bilirubin, direct bilirubin, alkaline phosphatase, gamma-glutamyltransferase, and total bile acid, showing their partial protective effects on cholestatic liver injury.	Emodin	37-43	gamma-glutamyltransferase 1	Rattus norvegicus	273-298
19067753-1	2009	AIM: The curative effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of the plant species Ventilago maderaspatana Gaertn, was evaluated against carbon tetrachloride (CCl(4)) induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural alterations in rats.	Emodin	28-34	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	218-233
19067753-1	2009	AIM: The curative effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of the plant species Ventilago maderaspatana Gaertn, was evaluated against carbon tetrachloride (CCl(4)) induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural alterations in rats.	Emodin	28-34	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	235-238
19152226-2	2009	Here, we report that the natural anthraquinones, emodin, emodic acid, chrysazin, physcion, and rhein differentially inhibit several members of this enzyme family, the gelatinases MMP-2 and -9, and the collagenase MMP-13.	Emodin	49-55	matrix metallopeptidase 13	Homo sapiens	213-219
19152226-4	2009	Emodin and emodic acid most potently inhibited MMP-9 with IC50 values of 15 and 10 microM, respectively.	Emodin	0-6	matrix metallopeptidase 9	Homo sapiens	47-52
18823377-10	2008	Cassialoin, chrysophanol-9-anthrone and aloe-emodin enhanced concanavalin A-induced IFN-gamma production in splenocytes of colon 26-bearing mice at a low concentration of 0.1 microM.	Emodin	45-51	interferon gamma	Mus musculus	84-93
17869316-4	2008	On the other hand, some flavones such as apigenin, flavonols such as quercetin, and anthraquinones such as emodin, showed notable inhibitory effects on the in vitro activation of AhR induced by the dioxin [2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)].	Emodin	107-113	aryl hydrocarbon receptor	Homo sapiens	179-182
18387517-4	2008	Interestingly, emodin induced the activation of phosphatidylinositol 3-kinase (PI3K), Akt and mitogen-activated protein (MAP) kinases, but those inductions by emodin were completely inhibited by the PI3K inhibitor, LY294002, suggesting that the up-regulation of BMP-2 by emodin could be mediated through the activation of both Akt and MAP kinases by activating PI3K.	Emodin	15-21	thymoma viral proto-oncogene 1	Mus musculus	86-89
18387517-4	2008	Interestingly, emodin induced the activation of phosphatidylinositol 3-kinase (PI3K), Akt and mitogen-activated protein (MAP) kinases, but those inductions by emodin were completely inhibited by the PI3K inhibitor, LY294002, suggesting that the up-regulation of BMP-2 by emodin could be mediated through the activation of both Akt and MAP kinases by activating PI3K.	Emodin	15-21	bone morphogenetic protein 2	Mus musculus	262-267
18387517-4	2008	Interestingly, emodin induced the activation of phosphatidylinositol 3-kinase (PI3K), Akt and mitogen-activated protein (MAP) kinases, but those inductions by emodin were completely inhibited by the PI3K inhibitor, LY294002, suggesting that the up-regulation of BMP-2 by emodin could be mediated through the activation of both Akt and MAP kinases by activating PI3K.	Emodin	15-21	thymoma viral proto-oncogene 1	Mus musculus	327-330
18387517-4	2008	Interestingly, emodin induced the activation of phosphatidylinositol 3-kinase (PI3K), Akt and mitogen-activated protein (MAP) kinases, but those inductions by emodin were completely inhibited by the PI3K inhibitor, LY294002, suggesting that the up-regulation of BMP-2 by emodin could be mediated through the activation of both Akt and MAP kinases by activating PI3K.	Emodin	159-165	bone morphogenetic protein 2	Mus musculus	262-267
18387517-4	2008	Interestingly, emodin induced the activation of phosphatidylinositol 3-kinase (PI3K), Akt and mitogen-activated protein (MAP) kinases, but those inductions by emodin were completely inhibited by the PI3K inhibitor, LY294002, suggesting that the up-regulation of BMP-2 by emodin could be mediated through the activation of both Akt and MAP kinases by activating PI3K.	Emodin	159-165	thymoma viral proto-oncogene 1	Mus musculus	327-330
15928809-3	2005	We found that emodin (3-methyl-1,6,8-trihydroxyanthraquinone), an active component from the rhizome of Rheum palmatum, significantly inhibited epidermal growth factor (EGF)- induced migration in various human cancer cell lines.	Emodin	14-20	epidermal growth factor	Homo sapiens	168-171
18242640-5	2008	We describe here the complex structure between a C-terminal deletion mutant of human CK2alpha and the ATP-competitive inhibitor emodin (1,3,8-trihydroxy-6-methylanthraquinone, International Union of Pure and Applied Chemistry name: 1,3,8-trihydroxy-6-methylanthracene-9,10-dione) and compare it with a previously published complex structure of emodin and maize CK2alpha.	Emodin	128-134	casein kinase 2 alpha 2	Homo sapiens	85-93
18242640-5	2008	We describe here the complex structure between a C-terminal deletion mutant of human CK2alpha and the ATP-competitive inhibitor emodin (1,3,8-trihydroxy-6-methylanthraquinone, International Union of Pure and Applied Chemistry name: 1,3,8-trihydroxy-6-methylanthracene-9,10-dione) and compare it with a previously published complex structure of emodin and maize CK2alpha.	Emodin	128-134	casein kinase II subunit alpha	Zea mays	361-369
18242640-5	2008	We describe here the complex structure between a C-terminal deletion mutant of human CK2alpha and the ATP-competitive inhibitor emodin (1,3,8-trihydroxy-6-methylanthraquinone, International Union of Pure and Applied Chemistry name: 1,3,8-trihydroxy-6-methylanthracene-9,10-dione) and compare it with a previously published complex structure of emodin and maize CK2alpha.	Emodin	136-174	casein kinase 2 alpha 2	Homo sapiens	85-93
18242640-5	2008	We describe here the complex structure between a C-terminal deletion mutant of human CK2alpha and the ATP-competitive inhibitor emodin (1,3,8-trihydroxy-6-methylanthraquinone, International Union of Pure and Applied Chemistry name: 1,3,8-trihydroxy-6-methylanthracene-9,10-dione) and compare it with a previously published complex structure of emodin and maize CK2alpha.	Emodin	136-174	casein kinase II subunit alpha	Zea mays	361-369
18242640-5	2008	We describe here the complex structure between a C-terminal deletion mutant of human CK2alpha and the ATP-competitive inhibitor emodin (1,3,8-trihydroxy-6-methylanthraquinone, International Union of Pure and Applied Chemistry name: 1,3,8-trihydroxy-6-methylanthracene-9,10-dione) and compare it with a previously published complex structure of emodin and maize CK2alpha.	Emodin	232-278	casein kinase 2 alpha 2	Homo sapiens	85-93
18242640-5	2008	We describe here the complex structure between a C-terminal deletion mutant of human CK2alpha and the ATP-competitive inhibitor emodin (1,3,8-trihydroxy-6-methylanthraquinone, International Union of Pure and Applied Chemistry name: 1,3,8-trihydroxy-6-methylanthracene-9,10-dione) and compare it with a previously published complex structure of emodin and maize CK2alpha.	Emodin	344-350	casein kinase 2 alpha 2	Homo sapiens	85-93
17230605-8	2007	RESULTS: In emodin-treated rats, the serum levels of HA and LN were decreased significantly (HA, 62.2 +/- 19.3 microg/L vs 112.7 +/- 26.5 microg/L, P < 0.05; LN 44.3 +/- 10.4 microg/L vs 86.2 +/- 16.5 microg/L, P < 0.05); the degree of fibrosis was ameliorated observably; the expression of collagen in pancreatic tissue was reduced especially in high-dose emodin-treated group (36% +/- 5% vs 42% +/- 6%, P < 0.05); with the increased doses of emodin, the expression of TGF-beta(1) was declined, compared with those in control group.	Emodin	12-18	transforming growth factor, beta 1	Rattus norvegicus	479-490
17198564-13	2006	(4) The protein content of TGF-beta(1) of the low-dose, mediate-dose, and high-dose emodin-treated groups were 44.3% +/- 2.1%, 39.2% +/- 1.8%, and 28.8% +/- 1.6% respectively, all significantly lower than that of the model control group (60.7% +/- 1.7%, all P < 0.05), and the protein content of TGF-beta(1) of the high-dose emodin-treated group was significantly lower than those of the other 2 emodin-treated groups (both P < 0.05).	Emodin	84-90	transforming growth factor, beta 1	Rattus norvegicus	27-38
17198564-13	2006	(4) The protein content of TGF-beta(1) of the low-dose, mediate-dose, and high-dose emodin-treated groups were 44.3% +/- 2.1%, 39.2% +/- 1.8%, and 28.8% +/- 1.6% respectively, all significantly lower than that of the model control group (60.7% +/- 1.7%, all P < 0.05), and the protein content of TGF-beta(1) of the high-dose emodin-treated group was significantly lower than those of the other 2 emodin-treated groups (both P < 0.05).	Emodin	84-90	transforming growth factor, beta 1	Rattus norvegicus	299-310
16342681-6	2005	Although acceleration of the decay rate of the K(V) currents was observed, the block by emodin was not through open block mechanism because a steady state level of inhibition of I(Kdr) was achieved during the first pulse from holding potential -70 mV to + 50 mV after the cells were holding at -70 mV for a three minutes interval in the presence of emodin.	Emodin	88-94	kinase insert domain receptor	Rattus norvegicus	180-183
17363492-1	2007	Emodin is an active component of a traditional Chinese and Japanese medicine isolated from the root and rhizomes of Rheum palmatum L. Here, we show that emodin significantly induces cytotoxicity in the human myeloma cells through the elimination of myeloid cell leukemia 1 (Mcl-1).	Emodin	153-159	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	249-272
17363492-1	2007	Emodin is an active component of a traditional Chinese and Japanese medicine isolated from the root and rhizomes of Rheum palmatum L. Here, we show that emodin significantly induces cytotoxicity in the human myeloma cells through the elimination of myeloid cell leukemia 1 (Mcl-1).	Emodin	153-159	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	274-279
17363492-5	2007	Induction of apoptosis by emodin was almost abrogated in Mcl-1-overexpressing myeloma cells as the same level as in parental cells, which were not treated with emodin.	Emodin	26-32	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	57-62
17623886-6	2007	Emodin, 3-methyl-1,6,8-trihydroxyanthraquinone, an active ingredient of an herb, has been recently shown of being able to induce CYP1 gene expression.	Emodin	0-6	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	129-133
17623886-6	2007	Emodin, 3-methyl-1,6,8-trihydroxyanthraquinone, an active ingredient of an herb, has been recently shown of being able to induce CYP1 gene expression.	Emodin	8-46	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	129-133
17198564-13	2006	(4) The protein content of TGF-beta(1) of the low-dose, mediate-dose, and high-dose emodin-treated groups were 44.3% +/- 2.1%, 39.2% +/- 1.8%, and 28.8% +/- 1.6% respectively, all significantly lower than that of the model control group (60.7% +/- 1.7%, all P < 0.05), and the protein content of TGF-beta(1) of the high-dose emodin-treated group was significantly lower than those of the other 2 emodin-treated groups (both P < 0.05).	Emodin	328-334	transforming growth factor, beta 1	Rattus norvegicus	27-38
15928809-3	2005	We found that emodin (3-methyl-1,6,8-trihydroxyanthraquinone), an active component from the rhizome of Rheum palmatum, significantly inhibited epidermal growth factor (EGF)- induced migration in various human cancer cell lines.	Emodin	22-60	epidermal growth factor	Homo sapiens	168-171
15133857-6	2004	RESULTS: (1) Emodin dose-dependently caused colonic smooth muscle cells contraction; (2) emodin induced an increase in intracellular Ca2+ concentration; (3) the contractile responses induced by emodin were respectively inhibited by preincubation of the cells with ML-7 (an inhibitor of MLCK) and calphostin C (an inhibitor of PKC); (4) Incubation of cells with emodin caused translocation of PKCalpha from cytosolic area to the membrane.	Emodin	89-95	myosin light chain kinase 3	Rattus norvegicus	286-290
15451666-8	2004	Proteasome-dependent degradation of endogenous Id1 in HeLa cells is also stimulated by treatment with curcumin or emodin.	Emodin	114-120	inhibitor of DNA binding 1, HLH protein	Homo sapiens	47-50
15133857-6	2004	RESULTS: (1) Emodin dose-dependently caused colonic smooth muscle cells contraction; (2) emodin induced an increase in intracellular Ca2+ concentration; (3) the contractile responses induced by emodin were respectively inhibited by preincubation of the cells with ML-7 (an inhibitor of MLCK) and calphostin C (an inhibitor of PKC); (4) Incubation of cells with emodin caused translocation of PKCalpha from cytosolic area to the membrane.	Emodin	194-200	protein kinase C, alpha	Rattus norvegicus	326-329
15133857-6	2004	RESULTS: (1) Emodin dose-dependently caused colonic smooth muscle cells contraction; (2) emodin induced an increase in intracellular Ca2+ concentration; (3) the contractile responses induced by emodin were respectively inhibited by preincubation of the cells with ML-7 (an inhibitor of MLCK) and calphostin C (an inhibitor of PKC); (4) Incubation of cells with emodin caused translocation of PKCalpha from cytosolic area to the membrane.	Emodin	89-95	protein kinase C, alpha	Rattus norvegicus	326-329
15133857-6	2004	RESULTS: (1) Emodin dose-dependently caused colonic smooth muscle cells contraction; (2) emodin induced an increase in intracellular Ca2+ concentration; (3) the contractile responses induced by emodin were respectively inhibited by preincubation of the cells with ML-7 (an inhibitor of MLCK) and calphostin C (an inhibitor of PKC); (4) Incubation of cells with emodin caused translocation of PKCalpha from cytosolic area to the membrane.	Emodin	194-200	protein kinase C, alpha	Rattus norvegicus	392-400
15133857-6	2004	RESULTS: (1) Emodin dose-dependently caused colonic smooth muscle cells contraction; (2) emodin induced an increase in intracellular Ca2+ concentration; (3) the contractile responses induced by emodin were respectively inhibited by preincubation of the cells with ML-7 (an inhibitor of MLCK) and calphostin C (an inhibitor of PKC); (4) Incubation of cells with emodin caused translocation of PKCalpha from cytosolic area to the membrane.	Emodin	89-95	protein kinase C, alpha	Rattus norvegicus	392-400
15133857-6	2004	RESULTS: (1) Emodin dose-dependently caused colonic smooth muscle cells contraction; (2) emodin induced an increase in intracellular Ca2+ concentration; (3) the contractile responses induced by emodin were respectively inhibited by preincubation of the cells with ML-7 (an inhibitor of MLCK) and calphostin C (an inhibitor of PKC); (4) Incubation of cells with emodin caused translocation of PKCalpha from cytosolic area to the membrane.	Emodin	194-200	myosin light chain kinase 3	Rattus norvegicus	286-290
14644660-3	2003	We also investigated the AhR-dependent activities of cantharidin and emodin (in herbal extracts) in Ah-responsive MCF-7 human breast cells, HepG2 human liver cancer cells, and mouse Hepa-1 cells transiently or stably transfected with plasmids expressing a luciferase reporter gene linked to multiple copies of a consensus dioxin-responsive element.	Emodin	69-75	aryl hydrocarbon receptor	Homo sapiens	25-28
15120460-9	2004	The present investigation showed that the phytochemicals piperine, paeonol and emodin are potent MAO inhibitors whereas other compounds were inactive against any type of MAO at 100 microM in the present assay.	Emodin	79-85	monoamine oxidase A	Rattus norvegicus	97-100
14987952-7	2004	Taken together, emodin displays effective inhibitory effects on the growth of various human hepatoma cell lines and stimulates the expression of p53 and p21 that resulted in the cell cycle arrest of HepG2/C3A cells at G(2)/M phase.	Emodin	16-22	tumor protein p53	Homo sapiens	145-148
14987952-7	2004	Taken together, emodin displays effective inhibitory effects on the growth of various human hepatoma cell lines and stimulates the expression of p53 and p21 that resulted in the cell cycle arrest of HepG2/C3A cells at G(2)/M phase.	Emodin	16-22	H3 histone pseudogene 16	Homo sapiens	153-156
14987952-7	2004	Taken together, emodin displays effective inhibitory effects on the growth of various human hepatoma cell lines and stimulates the expression of p53 and p21 that resulted in the cell cycle arrest of HepG2/C3A cells at G(2)/M phase.	Emodin	16-22	complement C3	Homo sapiens	205-208
12191608-4	2002	Here, we present an overview of our present knowledge about CK2 inhibitors, with special reference to the information drawn from two recently solved crystal structures of CK2alpha in complex with emodin and with 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), this latter being the most specific CK2 inhibitor known to date.	Emodin	196-202	casein kinase 2 alpha 2	Homo sapiens	171-179
12846747-4	2003	Emodin (3-methyl-1,6,8 trihydroxyanthraquinone) has previously been demonstrated to reduce cell proliferation and fibronectin synthesis in cultured mesangial cells.	Emodin	0-6	fibronectin 1	Homo sapiens	114-125
12846747-4	2003	Emodin (3-methyl-1,6,8 trihydroxyanthraquinone) has previously been demonstrated to reduce cell proliferation and fibronectin synthesis in cultured mesangial cells.	Emodin	8-46	fibronectin 1	Homo sapiens	114-125
12657721-7	2003	Furthermore, our findings strongly suggest that increased inhibition of the antiapoptotic kinase Akt activation produced by the emodin/celecoxib combination treatment plays a key role in the mechanism by which this drug combination acts to enhance cell growth suppression and apoptosis in cultured C611B ChC cells and WBneu cells.	Emodin	128-134	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
11459643-7	2001	Emodin and 2,6-dihydroxyanthraquinone also inhibited 17beta-estradiol binding to human estrogen receptors (ERs) with K(i) values of 0.77 and 0.31microM for ERalpha and 1.5 and 0.69 microM for ERbeta.	Emodin	0-6	estrogen receptor 1	Homo sapiens	156-169
11903488-8	2001	Among the TKIs tested, the mitogenic effect of HGF could be more specifically inhibited by emodin and tyrphostin, that of EGF by methyl-2,5-dihydroxycinnamate, lavendustin A, and genistein, and that of IGF-I by geldanamycin.	Emodin	91-97	hepatocyte growth factor	Homo sapiens	47-50
11682458-7	2001	To elucidate whether the expression of protein kinase C (PKC) isozymes are involved in aloe-emodin- and emodin-induced apoptosis, this study examined the changes of PKC isozymes by Western blotting techniques during aloe-emodin- and emodin-induced apoptosis.	Emodin	92-98	proline rich transmembrane protein 2	Homo sapiens	39-55
11682458-7	2001	To elucidate whether the expression of protein kinase C (PKC) isozymes are involved in aloe-emodin- and emodin-induced apoptosis, this study examined the changes of PKC isozymes by Western blotting techniques during aloe-emodin- and emodin-induced apoptosis.	Emodin	92-98	proline rich transmembrane protein 2	Homo sapiens	57-60
11459643-7	2001	Emodin and 2,6-dihydroxyanthraquinone also inhibited 17beta-estradiol binding to human estrogen receptors (ERs) with K(i) values of 0.77 and 0.31microM for ERalpha and 1.5 and 0.69 microM for ERbeta.	Emodin	0-6	estrogen receptor 2	Homo sapiens	192-198
11887862-3	2001	This study investigated the effect of emodin (3-methyl-1,6,8-trihydroxyanthraquinone) on TGFbeta1 and fibronectin (FN) synthesis in human peritoneal mesothelial cells (HPMCs) under high glucose concentration.	Emodin	38-44	transforming growth factor beta 1	Homo sapiens	89-97
11887862-3	2001	This study investigated the effect of emodin (3-methyl-1,6,8-trihydroxyanthraquinone) on TGFbeta1 and fibronectin (FN) synthesis in human peritoneal mesothelial cells (HPMCs) under high glucose concentration.	Emodin	38-44	fibronectin 1	Homo sapiens	102-113
11887862-3	2001	This study investigated the effect of emodin (3-methyl-1,6,8-trihydroxyanthraquinone) on TGFbeta1 and fibronectin (FN) synthesis in human peritoneal mesothelial cells (HPMCs) under high glucose concentration.	Emodin	38-44	fibronectin 1	Homo sapiens	115-117
11887862-3	2001	This study investigated the effect of emodin (3-methyl-1,6,8-trihydroxyanthraquinone) on TGFbeta1 and fibronectin (FN) synthesis in human peritoneal mesothelial cells (HPMCs) under high glucose concentration.	Emodin	46-84	transforming growth factor beta 1	Homo sapiens	89-97
11887862-3	2001	This study investigated the effect of emodin (3-methyl-1,6,8-trihydroxyanthraquinone) on TGFbeta1 and fibronectin (FN) synthesis in human peritoneal mesothelial cells (HPMCs) under high glucose concentration.	Emodin	46-84	fibronectin 1	Homo sapiens	102-113
10037184-5	1999	Furthermore, the combination of emodin and paclitaxel synergistically inhibited the anchorage-dependent and -independent growth of HER-2/neu-overexpressing breast cancer cells in vitro and synergistically inhibited tumor growth and prolonged survival in athymic mice bearing s.c. xenografts of human tumor cells expressing high levels of p185neu.	Emodin	32-38	erb-b2 receptor tyrosine kinase 2	Mus musculus	131-136
10882732-1	2000	The structure of a complex between the catalytic subunit of Zea mays CK2 and the nucleotide binding site-directed inhibitor emodin (3-methyl-1,6,8-trihydroxyanthraquinone) was solved at 2.6-A resolution.	Emodin	124-130	Calcium-dependent protein kinase 6	Zea mays	69-72
10882732-1	2000	The structure of a complex between the catalytic subunit of Zea mays CK2 and the nucleotide binding site-directed inhibitor emodin (3-methyl-1,6,8-trihydroxyanthraquinone) was solved at 2.6-A resolution.	Emodin	132-170	Calcium-dependent protein kinase 6	Zea mays	69-72
11776026-3	2000	The emodin-treated rats were treated with low-dose, mediate-dose and high-dose emodin (20, 40 and 80 mg/kg body weight, once a day for 42 days) dissolved in 0.5% sodium carboxymethylcellulose (CMC), except receiving CCl4.	Emodin	4-10	C-C motif chemokine ligand 4	Rattus norvegicus	216-220
10037184-5	1999	Furthermore, the combination of emodin and paclitaxel synergistically inhibited the anchorage-dependent and -independent growth of HER-2/neu-overexpressing breast cancer cells in vitro and synergistically inhibited tumor growth and prolonged survival in athymic mice bearing s.c. xenografts of human tumor cells expressing high levels of p185neu.	Emodin	32-38	erb-b2 receptor tyrosine kinase 2	Mus musculus	137-140
9780008-0	1998	Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.	Emodin	0-6	tumor necrosis factor	Homo sapiens	57-60
9780008-0	1998	Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.	Emodin	0-6	nuclear factor kappa B subunit 1	Homo sapiens	69-78
9780008-0	1998	Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.	Emodin	8-46	tumor necrosis factor	Homo sapiens	57-60
9780008-0	1998	Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.	Emodin	8-46	nuclear factor kappa B subunit 1	Homo sapiens	69-78
8637714-0	1996	Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.	Emodin	130-136	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-22
21594402-1	1996	The tyrosine kinase inhibitor emodin (3-methyl-1,6,8-tridroxyanthaquinone) is known to preferentially suppress the growth of the HER-2/neu-overexpressing breast cancer cell line.	Emodin	30-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	129-134
21594402-1	1996	The tyrosine kinase inhibitor emodin (3-methyl-1,6,8-tridroxyanthaquinone) is known to preferentially suppress the growth of the HER-2/neu-overexpressing breast cancer cell line.	Emodin	30-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	135-138
8637714-0	1996	Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.	Emodin	130-136	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-26
16386736-1	2006	This study is to reveal the characteristics of bidirectional regulation of emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) and quercetin on gizzard smooth muscle myosin.	Emodin	83-122	myosin heavy chain 14	Homo sapiens	163-169
8737457-4	1996	Addition of lipopolysaccharide (LPS 10 mg.L-1) induced a higher level expression of c-myc mRNA within 30 min, maximal expression at 2.5 h and persisted for 6 h. This over-expressing of c-myc mRNA was markedly suppressed by emodin (25 mg.L-1), the inhibition of emodin on c-myc mRNA expression was still seen at 6 h, and the greatest suppressive effect was at 2.5 h. CONCLUSION: Emodin participating in its down-regulatory effect of c-myc mRNA over-expression contributes to its inhibitory action on MC.	Emodin	223-229	ribosomal protein L4	Rattus norvegicus	42-45
8737457-4	1996	Addition of lipopolysaccharide (LPS 10 mg.L-1) induced a higher level expression of c-myc mRNA within 30 min, maximal expression at 2.5 h and persisted for 6 h. This over-expressing of c-myc mRNA was markedly suppressed by emodin (25 mg.L-1), the inhibition of emodin on c-myc mRNA expression was still seen at 6 h, and the greatest suppressive effect was at 2.5 h. CONCLUSION: Emodin participating in its down-regulatory effect of c-myc mRNA over-expression contributes to its inhibitory action on MC.	Emodin	223-229	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	84-89
8737457-4	1996	Addition of lipopolysaccharide (LPS 10 mg.L-1) induced a higher level expression of c-myc mRNA within 30 min, maximal expression at 2.5 h and persisted for 6 h. This over-expressing of c-myc mRNA was markedly suppressed by emodin (25 mg.L-1), the inhibition of emodin on c-myc mRNA expression was still seen at 6 h, and the greatest suppressive effect was at 2.5 h. CONCLUSION: Emodin participating in its down-regulatory effect of c-myc mRNA over-expression contributes to its inhibitory action on MC.	Emodin	223-229	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	185-190
8737457-4	1996	Addition of lipopolysaccharide (LPS 10 mg.L-1) induced a higher level expression of c-myc mRNA within 30 min, maximal expression at 2.5 h and persisted for 6 h. This over-expressing of c-myc mRNA was markedly suppressed by emodin (25 mg.L-1), the inhibition of emodin on c-myc mRNA expression was still seen at 6 h, and the greatest suppressive effect was at 2.5 h. CONCLUSION: Emodin participating in its down-regulatory effect of c-myc mRNA over-expression contributes to its inhibitory action on MC.	Emodin	223-229	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	185-190
8737457-4	1996	Addition of lipopolysaccharide (LPS 10 mg.L-1) induced a higher level expression of c-myc mRNA within 30 min, maximal expression at 2.5 h and persisted for 6 h. This over-expressing of c-myc mRNA was markedly suppressed by emodin (25 mg.L-1), the inhibition of emodin on c-myc mRNA expression was still seen at 6 h, and the greatest suppressive effect was at 2.5 h. CONCLUSION: Emodin participating in its down-regulatory effect of c-myc mRNA over-expression contributes to its inhibitory action on MC.	Emodin	223-229	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	185-190
33812418-0	2021	[Effects of Emodin Derivative on Cell Cycle, Apoptosis and NF-kappaB Pathway in Burkitt Lymphoma Cells].	Emodin	12-18	nuclear factor kappa B subunit 1	Homo sapiens	59-68
33776462-10	2021	The potential mechanisms by which emodin exerts its renoprotective effects in vivo are through suppressing cell apoptosis and enhancing autophagy of podocytes via the AMPK/mTOR signaling pathway in the kidney.	Emodin	34-40	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	167-171
33776462-10	2021	The potential mechanisms by which emodin exerts its renoprotective effects in vivo are through suppressing cell apoptosis and enhancing autophagy of podocytes via the AMPK/mTOR signaling pathway in the kidney.	Emodin	34-40	mechanistic target of rapamycin kinase	Rattus norvegicus	172-176
1466788-4	1992	Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) is inhibited by a range of di-, tri- and tetrahydroxylated anthraquinones (IC50 values 2 to 53 microM), the most potent inhibitors being the more polar compounds, namely mitoxantrone (IC50 2 microM) and emodin (1,3,8-trihydroxy-6-methylanthraquinone) (IC50 8 microM).	Emodin	264-270	calmodulin 1	Rattus norvegicus	7-17
1466788-4	1992	Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) is inhibited by a range of di-, tri- and tetrahydroxylated anthraquinones (IC50 values 2 to 53 microM), the most potent inhibitors being the more polar compounds, namely mitoxantrone (IC50 2 microM) and emodin (1,3,8-trihydroxy-6-methylanthraquinone) (IC50 8 microM).	Emodin	264-270	myosin light chain kinase	Rattus norvegicus	28-53
1466788-4	1992	Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) is inhibited by a range of di-, tri- and tetrahydroxylated anthraquinones (IC50 values 2 to 53 microM), the most potent inhibitors being the more polar compounds, namely mitoxantrone (IC50 2 microM) and emodin (1,3,8-trihydroxy-6-methylanthraquinone) (IC50 8 microM).	Emodin	264-270	myosin light chain kinase	Rattus norvegicus	55-59
1466788-4	1992	Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) is inhibited by a range of di-, tri- and tetrahydroxylated anthraquinones (IC50 values 2 to 53 microM), the most potent inhibitors being the more polar compounds, namely mitoxantrone (IC50 2 microM) and emodin (1,3,8-trihydroxy-6-methylanthraquinone) (IC50 8 microM).	Emodin	272-310	calmodulin 1	Rattus norvegicus	7-17
1466788-4	1992	Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) is inhibited by a range of di-, tri- and tetrahydroxylated anthraquinones (IC50 values 2 to 53 microM), the most potent inhibitors being the more polar compounds, namely mitoxantrone (IC50 2 microM) and emodin (1,3,8-trihydroxy-6-methylanthraquinone) (IC50 8 microM).	Emodin	272-310	myosin light chain kinase	Rattus norvegicus	28-53
1466788-4	1992	Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) is inhibited by a range of di-, tri- and tetrahydroxylated anthraquinones (IC50 values 2 to 53 microM), the most potent inhibitors being the more polar compounds, namely mitoxantrone (IC50 2 microM) and emodin (1,3,8-trihydroxy-6-methylanthraquinone) (IC50 8 microM).	Emodin	272-310	myosin light chain kinase	Rattus norvegicus	55-59
1466788-7	1992	In a number of cases compounds acting as potent inhibitors of MLCK (such as mitoxantrone and emodin) are very poor inhibitors of cAK and vice versa.	Emodin	93-99	myosin light chain kinase	Rattus norvegicus	62-66
1466788-7	1992	In a number of cases compounds acting as potent inhibitors of MLCK (such as mitoxantrone and emodin) are very poor inhibitors of cAK and vice versa.	Emodin	93-99	cyclin-dependent kinase 7	Rattus norvegicus	129-132
33776462-0	2021	Emodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway.	Emodin	0-6	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	106-110
33776462-0	2021	Emodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway.	Emodin	0-6	mechanistic target of rapamycin kinase	Rattus norvegicus	111-115
33776462-3	2021	The present study aimed to elucidate the mechanism of emodin in improving renal tissue and podocyte injury in DN by regulating the AMPK/mTOR-autophagy signaling pathway.	Emodin	54-60	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	131-135
33776462-3	2021	The present study aimed to elucidate the mechanism of emodin in improving renal tissue and podocyte injury in DN by regulating the AMPK/mTOR-autophagy signaling pathway.	Emodin	54-60	mechanistic target of rapamycin kinase	Rattus norvegicus	136-140
33776462-8	2021	In addition, emodin can induce and enhance autophagy in podocytes including increased expression of LC3-II/I, Beclin-1, p-AMPK protein and decreased expression of p62, p-mTOR protein, as well as increased autophagosomes in podocytes.	Emodin	13-19	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	100-108
33776462-8	2021	In addition, emodin can induce and enhance autophagy in podocytes including increased expression of LC3-II/I, Beclin-1, p-AMPK protein and decreased expression of p62, p-mTOR protein, as well as increased autophagosomes in podocytes.	Emodin	13-19	beclin 1	Rattus norvegicus	110-118
33776462-8	2021	In addition, emodin can induce and enhance autophagy in podocytes including increased expression of LC3-II/I, Beclin-1, p-AMPK protein and decreased expression of p62, p-mTOR protein, as well as increased autophagosomes in podocytes.	Emodin	13-19	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	122-126
33776462-8	2021	In addition, emodin can induce and enhance autophagy in podocytes including increased expression of LC3-II/I, Beclin-1, p-AMPK protein and decreased expression of p62, p-mTOR protein, as well as increased autophagosomes in podocytes.	Emodin	13-19	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	163-166
33776462-8	2021	In addition, emodin can induce and enhance autophagy in podocytes including increased expression of LC3-II/I, Beclin-1, p-AMPK protein and decreased expression of p62, p-mTOR protein, as well as increased autophagosomes in podocytes.	Emodin	13-19	mechanistic target of rapamycin kinase	Rattus norvegicus	170-174
33817118-0	2018	Emodin Promotes Apoptosis of Human Endometrial Cancer Through Regulating the MAPK and PI3K/ AKT Pathways.	Emodin	0-6	AKT serine/threonine kinase 1	Homo sapiens	92-95
33817118-4	2018	Western blot assay found that emodin was involved in MAPK and PI3K/Akt signaling pathways.	Emodin	30-36	AKT serine/threonine kinase 1	Homo sapiens	67-70
33817118-5	2018	Specifically, emodin significantly suppressed the phosphorylation of AKT, and enhanced the phosphorylation of MAPK pathways.	Emodin	14-20	AKT serine/threonine kinase 1	Homo sapiens	69-72
33817118-6	2018	Furthermore, the generation of reactive oxygen species (ROS) was up-regulated in KLE cells upon treatment with emodin, while the anti-oxidant agent N-acetyl cysteine (NAC) can inhibit emodin-induced apoptosis and promote the activation of AKT and Bcl-2.	Emodin	111-117	AKT serine/threonine kinase 1	Homo sapiens	239-242
33817118-6	2018	Furthermore, the generation of reactive oxygen species (ROS) was up-regulated in KLE cells upon treatment with emodin, while the anti-oxidant agent N-acetyl cysteine (NAC) can inhibit emodin-induced apoptosis and promote the activation of AKT and Bcl-2.	Emodin	111-117	BCL2 apoptosis regulator	Homo sapiens	247-252
33817118-6	2018	Furthermore, the generation of reactive oxygen species (ROS) was up-regulated in KLE cells upon treatment with emodin, while the anti-oxidant agent N-acetyl cysteine (NAC) can inhibit emodin-induced apoptosis and promote the activation of AKT and Bcl-2.	Emodin	184-190	AKT serine/threonine kinase 1	Homo sapiens	239-242
33817118-6	2018	Furthermore, the generation of reactive oxygen species (ROS) was up-regulated in KLE cells upon treatment with emodin, while the anti-oxidant agent N-acetyl cysteine (NAC) can inhibit emodin-induced apoptosis and promote the activation of AKT and Bcl-2.	Emodin	184-190	BCL2 apoptosis regulator	Homo sapiens	247-252
33817118-7	2018	Taken together, we revealed that emodin may induce apoptosis in KLE cells through regulating the PI3K/AKT and MAPK signaling pathways, indicating the importance of emodin as an anti-tumor agent.	Emodin	33-39	AKT serine/threonine kinase 1	Homo sapiens	102-105
34793771-0	2022	Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission.	Emodin	0-6	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	69-75
34958913-0	2022	Emodin alleviates aortic valvular calcification by inhibiting the AKT/FOXO1 pathway.	Emodin	0-6	thymoma viral proto-oncogene 1	Mus musculus	66-69
34958913-0	2022	Emodin alleviates aortic valvular calcification by inhibiting the AKT/FOXO1 pathway.	Emodin	0-6	forkhead box O1	Mus musculus	70-75
34958913-7	2022	The elevations of calcium content in serum and valve, and calcium accumulation in valve and artery were suppressed by emodin in mice with valvular calcification after joint treatment with adenine and Vit D. In addition, p-AKT and p-FOXO1 were upregulated in PAVICs under high-calcium conditions, and this effect was reversed by emodin treatment.	Emodin	118-124	vitrin	Mus musculus	200-203
34958913-7	2022	The elevations of calcium content in serum and valve, and calcium accumulation in valve and artery were suppressed by emodin in mice with valvular calcification after joint treatment with adenine and Vit D. In addition, p-AKT and p-FOXO1 were upregulated in PAVICs under high-calcium conditions, and this effect was reversed by emodin treatment.	Emodin	118-124	thymoma viral proto-oncogene 1	Mus musculus	222-225
34958913-7	2022	The elevations of calcium content in serum and valve, and calcium accumulation in valve and artery were suppressed by emodin in mice with valvular calcification after joint treatment with adenine and Vit D. In addition, p-AKT and p-FOXO1 were upregulated in PAVICs under high-calcium conditions, and this effect was reversed by emodin treatment.	Emodin	118-124	forkhead box O1	Mus musculus	232-237
34958913-7	2022	The elevations of calcium content in serum and valve, and calcium accumulation in valve and artery were suppressed by emodin in mice with valvular calcification after joint treatment with adenine and Vit D. In addition, p-AKT and p-FOXO1 were upregulated in PAVICs under high-calcium conditions, and this effect was reversed by emodin treatment.	Emodin	328-334	vitrin	Mus musculus	200-203
34958913-7	2022	The elevations of calcium content in serum and valve, and calcium accumulation in valve and artery were suppressed by emodin in mice with valvular calcification after joint treatment with adenine and Vit D. In addition, p-AKT and p-FOXO1 were upregulated in PAVICs under high-calcium conditions, and this effect was reversed by emodin treatment.	Emodin	328-334	thymoma viral proto-oncogene 1	Mus musculus	222-225
34958913-7	2022	The elevations of calcium content in serum and valve, and calcium accumulation in valve and artery were suppressed by emodin in mice with valvular calcification after joint treatment with adenine and Vit D. In addition, p-AKT and p-FOXO1 were upregulated in PAVICs under high-calcium conditions, and this effect was reversed by emodin treatment.	Emodin	328-334	forkhead box O1	Mus musculus	232-237
34958913-9	2022	CONCLUSIONS: These data demonstrated emodin alleviates high-calcium-associated valvular calcification via AKT/FOXO1 signaling suppression, providing new insights into therapeutic strategies for clinical valvular calcification.	Emodin	37-43	forkhead box O1	Mus musculus	110-115
34409550-0	2022	Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway.	Emodin	0-6	cyclic GMP-AMP synthase	Mus musculus	63-67
34409550-7	2022	Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1).	Emodin	0-6	glutamic pyruvic transaminase, soluble	Mus musculus	56-59
34409550-7	2022	Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1).	Emodin	0-6	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	61-64
34409550-7	2022	Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1).	Emodin	0-6	albumin	Mus musculus	99-102
34409550-7	2022	Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1).	Emodin	0-6	nuclear factor, erythroid derived 2, like 2	Mus musculus	287-330
34409550-7	2022	Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1).	Emodin	0-6	nuclear factor, erythroid derived 2, like 2	Mus musculus	332-336
34409550-7	2022	Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1).	Emodin	0-6	heme oxygenase 1	Mus musculus	339-355
34409550-7	2022	Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1).	Emodin	0-6	heme oxygenase 1	Mus musculus	357-361
34793771-0	2022	Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission.	Emodin	0-6	dynamin 1-like	Mus musculus	76-80
34409550-7	2022	Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1).	Emodin	0-6	NAD(P)H dehydrogenase, quinone 1	Mus musculus	368-399
34409550-7	2022	Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1).	Emodin	0-6	NAD(P)H dehydrogenase, quinone 1	Mus musculus	401-405
34409550-8	2022	Emodin also inhibited the expression of NLRP3 and reduced the levels of pro-inflammatory factors, including interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha).	Emodin	0-6	NLR family, pyrin domain containing 3	Mus musculus	40-45
34793771-10	2022	The phosphorylation of dynamin-related protein 1 (DRP1) at Ser616, a master regulator of mitochondrial fission, was upregulated in both models of I/R and H/R injury, and this upregulation was blocked by emodin.	Emodin	203-209	dynamin 1-like	Mus musculus	23-48
34409550-8	2022	Emodin also inhibited the expression of NLRP3 and reduced the levels of pro-inflammatory factors, including interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha).	Emodin	0-6	interleukin 1 beta	Mus musculus	108-126
34409550-8	2022	Emodin also inhibited the expression of NLRP3 and reduced the levels of pro-inflammatory factors, including interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha).	Emodin	0-6	interleukin 1 alpha	Mus musculus	128-136
34793771-10	2022	The phosphorylation of dynamin-related protein 1 (DRP1) at Ser616, a master regulator of mitochondrial fission, was upregulated in both models of I/R and H/R injury, and this upregulation was blocked by emodin.	Emodin	203-209	dynamin 1-like	Mus musculus	50-54
34409550-8	2022	Emodin also inhibited the expression of NLRP3 and reduced the levels of pro-inflammatory factors, including interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha).	Emodin	0-6	interleukin 6	Mus musculus	139-143
34793771-11	2022	Using computational cognate protein kinase prediction and specific kinase inhibitors, we found that emodin inhibited the phosphorylation of calcium/calmodulin-dependent protein kinase II (https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1554), thereby inhibiting its kinase activity and reducing the phosphorylation of DRP1 at Ser616.	Emodin	100-106	dynamin 1-like	Mus musculus	341-345
34409550-8	2022	Emodin also inhibited the expression of NLRP3 and reduced the levels of pro-inflammatory factors, including interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha).	Emodin	0-6	tumor necrosis factor	Mus musculus	149-176
34866324-8	2022	Further results found that treatment with EM up-regulated AMPKalpha, LDLR, ABCA1 and ABCG1, and down-regulated SREBP-2, PCSK9 and HMGCR expression.	Emodin	42-44	low density lipoprotein receptor a	Danio rerio	69-73
34409550-8	2022	Emodin also inhibited the expression of NLRP3 and reduced the levels of pro-inflammatory factors, including interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha).	Emodin	0-6	tumor necrosis factor	Mus musculus	178-187
34409550-9	2022	Emodin inhibited interferon (IFN)-alpha, cyclic GMP-AMP synthase (cGAS), and its downstream signaling effector stimulator of interferon genes (STING) expression to protect the liver against APAP-induced inflammatory responses and apoptosis.	Emodin	0-6	interferon alpha	Mus musculus	17-39
34409550-9	2022	Emodin inhibited interferon (IFN)-alpha, cyclic GMP-AMP synthase (cGAS), and its downstream signaling effector stimulator of interferon genes (STING) expression to protect the liver against APAP-induced inflammatory responses and apoptosis.	Emodin	0-6	cyclic GMP-AMP synthase	Mus musculus	41-64
34409550-9	2022	Emodin inhibited interferon (IFN)-alpha, cyclic GMP-AMP synthase (cGAS), and its downstream signaling effector stimulator of interferon genes (STING) expression to protect the liver against APAP-induced inflammatory responses and apoptosis.	Emodin	0-6	cyclic GMP-AMP synthase	Mus musculus	66-70
34409550-10	2022	These results suggest that emodin protected hepatocytes from APAP-induced liver injury via the upregulation of the Nrf2-mediated antioxidative stress pathway, the inhibition of the NLRP3 inflammasome, and the downregulation of the cGAS-STING signaling pathway.	Emodin	27-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
34409550-10	2022	These results suggest that emodin protected hepatocytes from APAP-induced liver injury via the upregulation of the Nrf2-mediated antioxidative stress pathway, the inhibition of the NLRP3 inflammasome, and the downregulation of the cGAS-STING signaling pathway.	Emodin	27-33	NLR family, pyrin domain containing 3	Mus musculus	181-186
34409550-10	2022	These results suggest that emodin protected hepatocytes from APAP-induced liver injury via the upregulation of the Nrf2-mediated antioxidative stress pathway, the inhibition of the NLRP3 inflammasome, and the downregulation of the cGAS-STING signaling pathway.	Emodin	27-33	cyclic GMP-AMP synthase	Mus musculus	231-235
34987380-10	2021	In addition, emodin could inhibit the expressions of TNF-alpha, IL-6 and MDA in serum and tissue, and increase the levels of SOD and GSH.	Emodin	13-19	tumor necrosis factor	Mus musculus	53-62
34987380-10	2021	In addition, emodin could inhibit the expressions of TNF-alpha, IL-6 and MDA in serum and tissue, and increase the levels of SOD and GSH.	Emodin	13-19	interleukin 6	Mus musculus	64-68
34987380-11	2021	The protective effect of emodin was confirmed in NCM460 cells and mice, where VDR was suppressed.	Emodin	25-31	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	78-81
34987380-13	2021	Conclusion: Emodin has a good protective effect against sepsis related intestinal mucosal barrier injury, possibly through the VDR/ Nrf2 /HO-1 pathway.	Emodin	12-18	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	127-130
34987380-13	2021	Conclusion: Emodin has a good protective effect against sepsis related intestinal mucosal barrier injury, possibly through the VDR/ Nrf2 /HO-1 pathway.	Emodin	12-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	132-136
34987380-13	2021	Conclusion: Emodin has a good protective effect against sepsis related intestinal mucosal barrier injury, possibly through the VDR/ Nrf2 /HO-1 pathway.	Emodin	12-18	heme oxygenase 1	Mus musculus	138-142
34872094-0	2022	Emodin Promotes Autophagy and Prevents Apoptosis in Sepsis-Associated Encephalopathy through Activating BDNF/TrkB Signaling.	Emodin	0-6	brain derived neurotrophic factor	Mus musculus	104-108
34872094-0	2022	Emodin Promotes Autophagy and Prevents Apoptosis in Sepsis-Associated Encephalopathy through Activating BDNF/TrkB Signaling.	Emodin	0-6	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	109-113
34872094-13	2022	Meanwhile, Emodin notably inhibited CLP-induced inflammatory responses in mice via upregulation of BDNF/TrkB signaling, while the effect of Emodin was partially reversed in the presence of K252a (BDNF/TrkB signaling inhibitor).	Emodin	11-17	brain derived neurotrophic factor	Mus musculus	99-103
34872094-13	2022	Meanwhile, Emodin notably inhibited CLP-induced inflammatory responses in mice via upregulation of BDNF/TrkB signaling, while the effect of Emodin was partially reversed in the presence of K252a (BDNF/TrkB signaling inhibitor).	Emodin	11-17	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	104-108
34872094-13	2022	Meanwhile, Emodin notably inhibited CLP-induced inflammatory responses in mice via upregulation of BDNF/TrkB signaling, while the effect of Emodin was partially reversed in the presence of K252a (BDNF/TrkB signaling inhibitor).	Emodin	11-17	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	201-205
34872094-13	2022	Meanwhile, Emodin notably inhibited CLP-induced inflammatory responses in mice via upregulation of BDNF/TrkB signaling, while the effect of Emodin was partially reversed in the presence of K252a (BDNF/TrkB signaling inhibitor).	Emodin	140-146	brain derived neurotrophic factor	Mus musculus	196-200
34872094-13	2022	Meanwhile, Emodin notably inhibited CLP-induced inflammatory responses in mice via upregulation of BDNF/TrkB signaling, while the effect of Emodin was partially reversed in the presence of K252a (BDNF/TrkB signaling inhibitor).	Emodin	140-146	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	201-205
34872094-14	2022	CONCLUSION: Emodin significantly inhibited the progression of SAE via mediation of BDNF/TrkB signaling.	Emodin	12-18	brain derived neurotrophic factor	Mus musculus	83-87
34872094-14	2022	CONCLUSION: Emodin significantly inhibited the progression of SAE via mediation of BDNF/TrkB signaling.	Emodin	12-18	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	88-92
34971761-0	2022	Emodin ameliorates antioxidant capacity and exerts neuroprotective effect via PKM2-mediated Nrf2 transactivation.	Emodin	0-6	pyruvate kinase M1/2	Rattus norvegicus	78-82
34971761-0	2022	Emodin ameliorates antioxidant capacity and exerts neuroprotective effect via PKM2-mediated Nrf2 transactivation.	Emodin	0-6	NFE2 like bZIP transcription factor 2	Rattus norvegicus	92-96
34971761-5	2022	Notably, emodin at nontoxic concentrations significantly inhibits PKM2 activity and promotes dissociation of tetrameric PKM2 into dimers in cells.	Emodin	9-15	pyruvate kinase M1/2	Rattus norvegicus	66-70
34971761-5	2022	Notably, emodin at nontoxic concentrations significantly inhibits PKM2 activity and promotes dissociation of tetrameric PKM2 into dimers in cells.	Emodin	9-15	pyruvate kinase M1/2	Rattus norvegicus	120-124
34971761-7	2022	Modulating the PKM2/Nrf2/ARE axis by emodin unveils a novel mechanism for understanding the pharmacological functions of emodin.	Emodin	37-43	pyruvate kinase M1/2	Rattus norvegicus	15-19
34971761-7	2022	Modulating the PKM2/Nrf2/ARE axis by emodin unveils a novel mechanism for understanding the pharmacological functions of emodin.	Emodin	37-43	NFE2 like bZIP transcription factor 2	Rattus norvegicus	20-24
34971761-7	2022	Modulating the PKM2/Nrf2/ARE axis by emodin unveils a novel mechanism for understanding the pharmacological functions of emodin.	Emodin	121-127	pyruvate kinase M1/2	Rattus norvegicus	15-19
34971761-7	2022	Modulating the PKM2/Nrf2/ARE axis by emodin unveils a novel mechanism for understanding the pharmacological functions of emodin.	Emodin	121-127	NFE2 like bZIP transcription factor 2	Rattus norvegicus	20-24
34952398-0	2022	Emodin inhibits NF-kappaB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin.	Emodin	0-6	nuclear factor kappa B subunit 1	Homo sapiens	16-25
34952398-0	2022	Emodin inhibits NF-kappaB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin.	Emodin	0-6	nicotinamide phosphoribosyltransferase	Rattus norvegicus	105-113
34952398-14	2022	In 16HBE, Emodin reversed Visfatin"s role in promoting cell viability, proliferation and activating NF-kappaB signaling pathway.	Emodin	10-16	nicotinamide phosphoribosyltransferase	Rattus norvegicus	26-34
34952398-14	2022	In 16HBE, Emodin reversed Visfatin"s role in promoting cell viability, proliferation and activating NF-kappaB signaling pathway.	Emodin	10-16	nuclear factor kappa B subunit 1	Homo sapiens	100-109
34952398-15	2022	CONCLUSION: Emodin inhibited NF-kappaB expression to relieve the pathological symptoms of obese asthmatic rats by Visfatin.	Emodin	12-18	nuclear factor kappa B subunit 1	Homo sapiens	29-38
34952398-15	2022	CONCLUSION: Emodin inhibited NF-kappaB expression to relieve the pathological symptoms of obese asthmatic rats by Visfatin.	Emodin	12-18	nicotinamide phosphoribosyltransferase	Rattus norvegicus	114-122
34411446-6	2022	However, the effect of emodin on AURKA has never been investigated.	Emodin	23-29	aurora kinase A	Homo sapiens	33-38
34411446-11	2022	Furthermore, emodin inhibited the AURKA kinase activity in vitro and enhanced the cisplatin DNA adduct level in a resistant ovarian cancer cell line.	Emodin	13-19	aurora kinase A	Homo sapiens	34-39
34411446-13	2022	Collectively, our finding reveals a novel AURKA inhibitor, emodin, which may be vulnerable to ovarian cancer therapy in the future.	Emodin	59-65	aurora kinase A	Homo sapiens	42-47
34866324-8	2022	Further results found that treatment with EM up-regulated AMPKalpha, LDLR, ABCA1 and ABCG1, and down-regulated SREBP-2, PCSK9 and HMGCR expression.	Emodin	42-44	ATP-binding cassette, sub-family A (ABC1), member 7	Danio rerio	75-80
34866324-8	2022	Further results found that treatment with EM up-regulated AMPKalpha, LDLR, ABCA1 and ABCG1, and down-regulated SREBP-2, PCSK9 and HMGCR expression.	Emodin	42-44	ATP-binding cassette, sub-family G (WHITE), member 1	Danio rerio	85-90
34866324-8	2022	Further results found that treatment with EM up-regulated AMPKalpha, LDLR, ABCA1 and ABCG1, and down-regulated SREBP-2, PCSK9 and HMGCR expression.	Emodin	42-44	sterol regulatory element binding transcription factor 2	Danio rerio	111-118
34866324-8	2022	Further results found that treatment with EM up-regulated AMPKalpha, LDLR, ABCA1 and ABCG1, and down-regulated SREBP-2, PCSK9 and HMGCR expression.	Emodin	42-44	proprotein convertase subtilisin/kexin type 9	Danio rerio	120-125
34853399-7	2021	A screen of known viroporin inhibitors on Protein E, ORF7b, ORF10 and Protein 3a from SARS-CoV-2 revealed inhibition of Protein E and ORF7b by emodin and xanthene, the latter also blocking Protein 3a.	Emodin	143-149	ORF7b	Severe acute respiratory syndrome coronavirus 2	53-58
34839778-0	2021	Protective role of emodin in rats with post-myocardial infarction heart failure and influence on extracellular signal-regulated kinase pathway.	Emodin	19-25	Eph receptor B1	Rattus norvegicus	97-134
34839778-1	2021	We aimed to explore the effects of emodin on the energy metabolism of myocardial cells in rats with post-myocardial infarction (MI) heart failure (HF) and the extracellular signal-regulated kinase (ERK) pathway.	Emodin	35-41	Eph receptor B1	Rattus norvegicus	159-196
34839778-1	2021	We aimed to explore the effects of emodin on the energy metabolism of myocardial cells in rats with post-myocardial infarction (MI) heart failure (HF) and the extracellular signal-regulated kinase (ERK) pathway.	Emodin	35-41	Eph receptor B1	Rattus norvegicus	198-201
34615812-4	2021	Resultantly, the the Polygonum cuspidatum ethyl acetate subfraction containing emodin (F3a) promoted Raji cell death (50% cytotoxic concentration, CC50: 12.08 mug/mL); the 12.5 mug/mL F3a effect transcribed BRLF1 and BNLF1 and increased latent membrane protein 1 (LMP1), which may reduce the intracellular phospho-ERK and phospho-IkappaBalpha.	Emodin	79-85	PDZ and LIM domain 7	Homo sapiens	237-262
34615812-4	2021	Resultantly, the the Polygonum cuspidatum ethyl acetate subfraction containing emodin (F3a) promoted Raji cell death (50% cytotoxic concentration, CC50: 12.08 mug/mL); the 12.5 mug/mL F3a effect transcribed BRLF1 and BNLF1 and increased latent membrane protein 1 (LMP1), which may reduce the intracellular phospho-ERK and phospho-IkappaBalpha.	Emodin	79-85	PDZ and LIM domain 7	Homo sapiens	264-268
34615812-4	2021	Resultantly, the the Polygonum cuspidatum ethyl acetate subfraction containing emodin (F3a) promoted Raji cell death (50% cytotoxic concentration, CC50: 12.08 mug/mL); the 12.5 mug/mL F3a effect transcribed BRLF1 and BNLF1 and increased latent membrane protein 1 (LMP1), which may reduce the intracellular phospho-ERK and phospho-IkappaBalpha.	Emodin	79-85	mitogen-activated protein kinase 1	Homo sapiens	314-317
34615812-4	2021	Resultantly, the the Polygonum cuspidatum ethyl acetate subfraction containing emodin (F3a) promoted Raji cell death (50% cytotoxic concentration, CC50: 12.08 mug/mL); the 12.5 mug/mL F3a effect transcribed BRLF1 and BNLF1 and increased latent membrane protein 1 (LMP1), which may reduce the intracellular phospho-ERK and phospho-IkappaBalpha.	Emodin	79-85	NFKB inhibitor alpha	Homo sapiens	330-342
34853399-7	2021	A screen of known viroporin inhibitors on Protein E, ORF7b, ORF10 and Protein 3a from SARS-CoV-2 revealed inhibition of Protein E and ORF7b by emodin and xanthene, the latter also blocking Protein 3a.	Emodin	143-149	ORF10 protein	Severe acute respiratory syndrome coronavirus 2	60-65
34853399-7	2021	A screen of known viroporin inhibitors on Protein E, ORF7b, ORF10 and Protein 3a from SARS-CoV-2 revealed inhibition of Protein E and ORF7b by emodin and xanthene, the latter also blocking Protein 3a.	Emodin	143-149	ORF7b	Severe acute respiratory syndrome coronavirus 2	134-139
34379340-9	2021	Further study in vitro has shown that baicalin decreased the expression of CD14, whereas emodin increased the expression of PPAR-gamma, both of which inhibited the activity of NF-kappaB and exerted antiinflammatory effects.	Emodin	89-95	peroxisome proliferator activated receptor gamma	Mus musculus	124-134
34787801-0	2022	Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo.	Emodin	0-6	NLR family, pyrin domain containing 3	Rattus norvegicus	62-67
34787801-9	2022	In vitro, we demonstrated that emodin could inhibit NLRP3 and then inhibit the expression of ASC, CASP1, GSDMD, IL-1beta, and IL-18.	Emodin	31-37	NLR family, pyrin domain containing 3	Mus musculus	52-57
34787801-9	2022	In vitro, we demonstrated that emodin could inhibit NLRP3 and then inhibit the expression of ASC, CASP1, GSDMD, IL-1beta, and IL-18.	Emodin	31-37	caspase 1	Rattus norvegicus	98-103
34787801-9	2022	In vitro, we demonstrated that emodin could inhibit NLRP3 and then inhibit the expression of ASC, CASP1, GSDMD, IL-1beta, and IL-18.	Emodin	31-37	gasdermin D	Rattus norvegicus	105-110
34787801-9	2022	In vitro, we demonstrated that emodin could inhibit NLRP3 and then inhibit the expression of ASC, CASP1, GSDMD, IL-1beta, and IL-18.	Emodin	31-37	interleukin 1 alpha	Rattus norvegicus	112-120
34787801-9	2022	In vitro, we demonstrated that emodin could inhibit NLRP3 and then inhibit the expression of ASC, CASP1, GSDMD, IL-1beta, and IL-18.	Emodin	31-37	interleukin 18	Rattus norvegicus	126-131
34787801-10	2022	In vivo, we confirmed that emodin had protective effects on LPS-induced ALI and inhibitory effects on NLRP3 inflammasome -dependent pyroptosis.	Emodin	27-33	NLR family, pyrin domain containing 3	Mus musculus	102-107
34787801-11	2022	Emodin showed excellent protective effects against LPS-induced ALI by regulating the NLRP3 inflammasome-dependent pyroptosis signaling pathway.	Emodin	0-6	NLR family, pyrin domain containing 3	Mus musculus	85-90
34606778-5	2021	In this study, 1H NMR based metabolomics approach, complemented with histopathological observation, biochemical measurements, western blotting analysis and real-time quantitative PCR (RT-qPCR), was applied to interpret the paradox of emodin (30 mg/kg, 10 mg/kg BW) using both healthy mice (male, ICR) and chronic CCl4-injured mice (0.1 mL/kg, 0.35% CCl4, 3 times a week for a month).	Emodin	234-240	chemokine (C-C motif) ligand 4	Mus musculus	313-317
34606778-5	2021	In this study, 1H NMR based metabolomics approach, complemented with histopathological observation, biochemical measurements, western blotting analysis and real-time quantitative PCR (RT-qPCR), was applied to interpret the paradox of emodin (30 mg/kg, 10 mg/kg BW) using both healthy mice (male, ICR) and chronic CCl4-injured mice (0.1 mL/kg, 0.35% CCl4, 3 times a week for a month).	Emodin	234-240	chemokine (C-C motif) ligand 4	Mus musculus	349-353
34606778-6	2021	Emodin exerted a weight loss property associated with its lipid-lowing effects, which helped alleviate CCl4-induced steatosis.	Emodin	0-6	chemokine (C-C motif) ligand 4	Mus musculus	103-107
34606778-7	2021	Emodin effectively ameliorated CCl4-induced oxidative stress and energy metabolism dysfunction in mice liver via regulating glucose, lipid and amino acid metabolism, and inhibited excessive inflammatory response.	Emodin	0-6	chemokine (C-C motif) ligand 4	Mus musculus	31-35
34806822-0	2022	Emodin alleviates sepsis-mediated lung injury via inhibition and reduction of NF-kB and HMGB1 pathways mediated by SIRT1.	Emodin	0-6	high mobility group box 1	Mus musculus	88-93
34806822-0	2022	Emodin alleviates sepsis-mediated lung injury via inhibition and reduction of NF-kB and HMGB1 pathways mediated by SIRT1.	Emodin	0-6	sirtuin 1	Mus musculus	115-120
34806822-8	2022	Emodin significantly decreased CLP-induced cell apoptosis, upregulated expression of sirtuin 1 (SIRT1), and inhibited p-p65/p65 and HMGB1.	Emodin	0-6	sirtuin 1	Mus musculus	85-94
34806822-8	2022	Emodin significantly decreased CLP-induced cell apoptosis, upregulated expression of sirtuin 1 (SIRT1), and inhibited p-p65/p65 and HMGB1.	Emodin	0-6	sirtuin 1	Mus musculus	96-101
34806822-8	2022	Emodin significantly decreased CLP-induced cell apoptosis, upregulated expression of sirtuin 1 (SIRT1), and inhibited p-p65/p65 and HMGB1.	Emodin	0-6	lymphocyte cytosolic protein 1	Mus musculus	118-124
34806822-8	2022	Emodin significantly decreased CLP-induced cell apoptosis, upregulated expression of sirtuin 1 (SIRT1), and inhibited p-p65/p65 and HMGB1.	Emodin	0-6	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	124-127
34806822-8	2022	Emodin significantly decreased CLP-induced cell apoptosis, upregulated expression of sirtuin 1 (SIRT1), and inhibited p-p65/p65 and HMGB1.	Emodin	0-6	high mobility group box 1	Mus musculus	132-137
34806822-9	2022	In lipopolysaccharide (LPS) treated cell model, emodin treatment markedly decreased LPS-induced release of IL-1, IL-6, and tumor necrosis factor (TNF)-alpha, inhibited LPS-induced cell apoptosis and suppressed protein levels of P-P65/P65 and HMGB1.	Emodin	48-54	interleukin 1 complex	Mus musculus	107-111
34806822-9	2022	In lipopolysaccharide (LPS) treated cell model, emodin treatment markedly decreased LPS-induced release of IL-1, IL-6, and tumor necrosis factor (TNF)-alpha, inhibited LPS-induced cell apoptosis and suppressed protein levels of P-P65/P65 and HMGB1.	Emodin	48-54	interleukin 6	Mus musculus	113-117
34806822-9	2022	In lipopolysaccharide (LPS) treated cell model, emodin treatment markedly decreased LPS-induced release of IL-1, IL-6, and tumor necrosis factor (TNF)-alpha, inhibited LPS-induced cell apoptosis and suppressed protein levels of P-P65/P65 and HMGB1.	Emodin	48-54	tumor necrosis factor	Mus musculus	123-156
34806822-9	2022	In lipopolysaccharide (LPS) treated cell model, emodin treatment markedly decreased LPS-induced release of IL-1, IL-6, and tumor necrosis factor (TNF)-alpha, inhibited LPS-induced cell apoptosis and suppressed protein levels of P-P65/P65 and HMGB1.	Emodin	48-54	lymphocyte cytosolic protein 1	Mus musculus	228-237
34806822-9	2022	In lipopolysaccharide (LPS) treated cell model, emodin treatment markedly decreased LPS-induced release of IL-1, IL-6, and tumor necrosis factor (TNF)-alpha, inhibited LPS-induced cell apoptosis and suppressed protein levels of P-P65/P65 and HMGB1.	Emodin	48-54	high mobility group box 1	Mus musculus	242-247
34806822-10	2022	However, science of SIRT1 reversed the above effects by treatment of emodin.	Emodin	69-75	sirtuin 1	Mus musculus	20-25
34806822-11	2022	In summarize, this study found that emodin can alleviate sepsis-induced lung injury in vivo and in vitro through regulation of SIRT1.	Emodin	36-42	sirtuin 1	Mus musculus	127-132
34473407-7	2021	The docking results of emodin with Monoamine Oxidase A and Melatonin Receptor 1A, and luteolin with Solute Carrier Family 6 Member 4, Glyoxalase I, Monoamine Oxidase B and Melatonin Receptor 1A, may explain the mechanism of action of Baihe Dihuang decoction in treating insomnia and depression.	Emodin	23-29	monoamine oxidase A	Mus musculus	35-54
34498715-0	2021	Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1.	Emodin	0-6	taurine up-regulated 1	Rattus norvegicus	79-83
34498715-0	2021	Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1.	Emodin	0-6	taurine up-regulated 1	Rattus norvegicus	104-108
34498715-11	2021	The data indicated that emodin significantly decreased the levels of IL-1beta and TNF-alpha in the supernatant samples derived from AR42J cells cotreated with caerulein and LPS.	Emodin	24-30	interleukin 1 alpha	Rattus norvegicus	69-77
34498715-11	2021	The data indicated that emodin significantly decreased the levels of IL-1beta and TNF-alpha in the supernatant samples derived from AR42J cells cotreated with caerulein and LPS.	Emodin	24-30	tumor necrosis factor	Rattus norvegicus	82-91
34498715-12	2021	In addition, emodin significantly promoted the proliferation of AR42J cells cotreated with caerulein and LPS, and inhibited apoptosis, while the effect of emodin was reversed by long non-coding (lnc)RNA taurine upregulated 1 (TUG1) overexpression.	Emodin	13-19	taurine up-regulated 1	Rattus norvegicus	226-230
34498715-12	2021	In addition, emodin significantly promoted the proliferation of AR42J cells cotreated with caerulein and LPS, and inhibited apoptosis, while the effect of emodin was reversed by long non-coding (lnc)RNA taurine upregulated 1 (TUG1) overexpression.	Emodin	155-161	taurine up-regulated 1	Rattus norvegicus	226-230
34498715-13	2021	The expression level of TUG1 in AR42J cells or exosomes derived from AR42J cells was significantly increased following treatment of the cells with LPS and caerulein, while this effect was notably reversed by emodin treatment.	Emodin	208-214	taurine up-regulated 1	Rattus norvegicus	24-28
34171397-5	2021	OBJECTIVE: We aimed to investigate whether EMO activates farnesoid X receptor (FXR) signaling to alleviate HFD-induced NAFLD.	Emodin	43-46	nuclear receptor subfamily 1, group H, member 4	Mus musculus	57-77
34171397-5	2021	OBJECTIVE: We aimed to investigate whether EMO activates farnesoid X receptor (FXR) signaling to alleviate HFD-induced NAFLD.	Emodin	43-46	nuclear receptor subfamily 1, group H, member 4	Mus musculus	79-82
34171397-12	2021	EMO improved HFD-induced lipid accumulation, insulin resistance, inflammation, and oxidative stress in a dose-dependent manner in WT mice by inhibiting FXR expression.	Emodin	0-3	nuclear receptor subfamily 1, group H, member 4	Mus musculus	152-155
34171397-13	2021	EMO also significantly repressed TG hyperaccumulation by upregulating FXR expression in MPHs.	Emodin	0-3	nuclear receptor subfamily 1, group H, member 4	Mus musculus	70-73
34171397-15	2021	CONCLUSIONS: The present study demonstrated that EMO alleviates HFD-induced NAFLD by activating FXR signaling which improves lipid accumulation, insulin resistance, inflammation, and oxidative stress.	Emodin	49-52	nuclear receptor subfamily 1, group H, member 4	Mus musculus	96-99
34744735-6	2021	The results showed that emodin can alleviate the pain response of migraine rats and significantly reduce the levels of NO, CGRP, SP, TNF-alpha and cGMP in migraine rats.	Emodin	24-30	calcitonin-related polypeptide alpha	Rattus norvegicus	123-127
34744735-6	2021	The results showed that emodin can alleviate the pain response of migraine rats and significantly reduce the levels of NO, CGRP, SP, TNF-alpha and cGMP in migraine rats.	Emodin	24-30	tumor necrosis factor	Rattus norvegicus	133-142
34744735-7	2021	In addition, emodin can significantly reduce the number of c-Fos positive cells and the IOD value.	Emodin	13-19	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-64
34447468-14	2021	In addition, the results of the present study demonstrated that emodin inhibited the MEK/ERK pathway.	Emodin	64-70	midkine	Mus musculus	85-88
34447468-14	2021	In addition, the results of the present study demonstrated that emodin inhibited the MEK/ERK pathway.	Emodin	64-70	mitogen-activated protein kinase 1	Mus musculus	89-92
34379340-9	2021	Further study in vitro has shown that baicalin decreased the expression of CD14, whereas emodin increased the expression of PPAR-gamma, both of which inhibited the activity of NF-kappaB and exerted antiinflammatory effects.	Emodin	89-95	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	176-185
34379340-10	2021	Furthermore, compared to the treatment using the two drugs individually, baicalin combined with emodin had more significant effects on the expression of CD14 and PPAR-gamma.	Emodin	96-102	CD14 antigen	Mus musculus	153-157
34379340-10	2021	Furthermore, compared to the treatment using the two drugs individually, baicalin combined with emodin had more significant effects on the expression of CD14 and PPAR-gamma.	Emodin	96-102	peroxisome proliferator activated receptor gamma	Mus musculus	162-172
34540999-0	2021	Anti-influenza A Virus Effects and Mechanisms of Emodin and Its Analogs via Regulating PPARalpha/gamma-AMPK-SIRT1 Pathway and Fatty Acid Metabolism.	Emodin	49-55	peroxisome proliferator activated receptor alpha	Homo sapiens	87-96
34873451-6	2021	A combined fluorescence potassium ion assay with three channel modulators (4-aminopyridine, emodin-Orf3a channel blocker, and gliclazide-E channel blocker) was developed to detect SARS-CoV-2 Orf3a/E channel activity.	Emodin	92-98	ORF3a protein	Severe acute respiratory syndrome coronavirus 2	99-104
34873451-8	2021	Results: In lentivirus-spiked samples, we detected significant channel activity of Orf3a/E based on increase in fluorescence induced by 4-aminopyridine, and this increase in fluorescence was inhibited by emodin and gliclazide.	Emodin	204-210	ORF3a protein	Severe acute respiratory syndrome coronavirus 2	83-88
34492313-0	2021	Insight into the Practical Models for Prediciting the Essential Role of the Cytochrome P450-mediated Biotransformation in Emodin-associated Hepatotoxicity.	Emodin	122-128	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	76-91
34492313-9	2021	on mice, as emodin treatment only mediated slight increase of liver index and histological score likely due to the metabolic detoxication of emodin, whereas ABT co-administration resulted in severe liver injury as reflected by the dramatic increase of the liver index value, serum ALT and AST levels, and histopathological score.	Emodin	12-18	glutamic pyruvic transaminase, soluble	Mus musculus	281-284
34632188-4	2021	We have identified five compounds: 1,4-naphthoquinone, emodin, shikonin, plumbagin, and menadione (vitamin K3) as active and selective inhibitors of human IRAK1 enzyme in vitro.	Emodin	55-61	interleukin 1 receptor associated kinase 1	Homo sapiens	155-160
34540999-0	2021	Anti-influenza A Virus Effects and Mechanisms of Emodin and Its Analogs via Regulating PPARalpha/gamma-AMPK-SIRT1 Pathway and Fatty Acid Metabolism.	Emodin	49-55	sirtuin 1	Homo sapiens	108-113
34540999-8	2021	The pharmacological tests showed that emodin significantly activated PPARalpha/gamma and AMPK, decreased fatty acid biosynthesis, and increased intracellular ATP levels.	Emodin	38-44	peroxisome proliferator activated receptor alpha	Homo sapiens	69-78
34540999-9	2021	Pharmaceutical inhibitors, siRNAs for PPARalpha/gamma and AMPKalpha1, and exogenous palmitate impaired the inhibition of emodin.	Emodin	121-127	peroxisome proliferator activated receptor alpha	Homo sapiens	38-53
34540999-9	2021	Pharmaceutical inhibitors, siRNAs for PPARalpha/gamma and AMPKalpha1, and exogenous palmitate impaired the inhibition of emodin.	Emodin	121-127	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	58-68
34540999-11	2021	Pharmacological inhibitors for PPARalpha/gamma and AMPK signal and exogenous palmitate could partially counteract the effects of emodin in vivo.	Emodin	129-135	peroxisome proliferator activated receptor alpha	Homo sapiens	31-46
34540999-12	2021	In conclusion, emodin and its analogs are a group of promising anti-IAV drug precursors, and the pharmacological mechanism of emodin is linked to its ability to regulate the PPARalpha/gamma-AMPK pathway and fatty acid metabolism.	Emodin	15-21	peroxisome proliferator activated receptor alpha	Homo sapiens	174-183
34540999-12	2021	In conclusion, emodin and its analogs are a group of promising anti-IAV drug precursors, and the pharmacological mechanism of emodin is linked to its ability to regulate the PPARalpha/gamma-AMPK pathway and fatty acid metabolism.	Emodin	126-132	peroxisome proliferator activated receptor alpha	Homo sapiens	174-183
34217968-13	2021	Inhibition of MAPK p38 (p38) in the hippocampus was observed after DCQ and emodin treatment.	Emodin	75-81	mitogen activated protein kinase 14	Rattus norvegicus	24-27
34173707-6	2021	Moreover, we demonstrated the ameliorating effect of emodin on carbon tetrachloride (CCl4 )-induced liver injury in mice.	Emodin	53-59	chemokine (C-C motif) ligand 4	Mus musculus	85-89
34173707-11	2021	Besides, the molecule docking results showed that emodin could directly interact with p53 by binding the active site residues ASN345, GLN331 and TYR347.	Emodin	50-56	transformation related protein 53, pseudogene	Mus musculus	86-89
34173707-13	2021	Moreover, our study confirmed that emodin alleviated CCl4 -induced liver injury in mice,inducing hepatic stellate cells (HSCs) apoptosis via regulating the p53/ERK/p38 axis.	Emodin	35-41	chemokine (C-C motif) ligand 4	Mus musculus	53-57
34173707-13	2021	Moreover, our study confirmed that emodin alleviated CCl4 -induced liver injury in mice,inducing hepatic stellate cells (HSCs) apoptosis via regulating the p53/ERK/p38 axis.	Emodin	35-41	transformation related protein 53, pseudogene	Mus musculus	156-159
34173707-13	2021	Moreover, our study confirmed that emodin alleviated CCl4 -induced liver injury in mice,inducing hepatic stellate cells (HSCs) apoptosis via regulating the p53/ERK/p38 axis.	Emodin	35-41	mitogen-activated protein kinase 1	Mus musculus	160-163
34173707-13	2021	Moreover, our study confirmed that emodin alleviated CCl4 -induced liver injury in mice,inducing hepatic stellate cells (HSCs) apoptosis via regulating the p53/ERK/p38 axis.	Emodin	35-41	mitogen-activated protein kinase 14	Mus musculus	164-167
34173707-14	2021	CONCLUSIONS: This study partially verified the network pharmacological prediction of emodin inducing HSCs cell apoptosis through the p53/ERK/p38 axis.	Emodin	85-91	transformation related protein 53, pseudogene	Mus musculus	133-136
34173707-14	2021	CONCLUSIONS: This study partially verified the network pharmacological prediction of emodin inducing HSCs cell apoptosis through the p53/ERK/p38 axis.	Emodin	85-91	mitogen-activated protein kinase 1	Mus musculus	137-140
34173707-14	2021	CONCLUSIONS: This study partially verified the network pharmacological prediction of emodin inducing HSCs cell apoptosis through the p53/ERK/p38 axis.	Emodin	85-91	mitogen-activated protein kinase 14	Mus musculus	141-144
34131970-0	2021	Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation.	Emodin	0-6	NLR family, pyrin domain containing 3	Mus musculus	70-75
34131970-8	2021	In vitro, emodin alleviated LPS-induced cell injury and inflammation in cardiomyocytes by inhibiting NLRP3 inflammasome activation.	Emodin	10-16	NLR family, pyrin domain containing 3	Mus musculus	101-106
34131970-10	2021	Taken together, our findings suggest that emodin improves LPS-induced myocardial injury and cardiac dysfunction by alleviating the inflammatory response and cardiomyocyte pyroptosis by inhibiting NLRP3 inflammasome activation, which provides a feasible strategy for preventing and treating myocardial injury in sepsis.	Emodin	42-48	NLR family, pyrin domain containing 3	Mus musculus	196-201
34340305-6	2021	Molecular docking revealed FDA drugs ozanimod, siponimod, teriflunomide, and phytochemicals; emodin; protoapigenone; and EGCG bound to EBNA1 with high affinities.	Emodin	93-99	EBNA-1	Human gammaherpesvirus 4	135-140
34332565-0	2021	Emodin inhibits viability, proliferation and promotes apoptosis of hypoxic human pulmonary artery smooth muscle cells via targeting miR-244-5p/DEGS1 axis.	Emodin	0-6	delta 4-desaturase, sphingolipid 1	Homo sapiens	143-148
34422078-21	2021	Molecular docking analysis showed that salvianolic acid B and emodin had a good binding affinity toward Keap-1.	Emodin	62-68	Kelch-like ECH-associated protein 1	Rattus norvegicus	104-110
34178130-0	2021	Emodin ameliorates acute pancreatitis-induced lung injury by suppressing NLRP3 inflammasome-mediated neutrophil recruitment.	Emodin	0-6	NLR family, pyrin domain containing 3	Rattus norvegicus	73-78
34178130-10	2021	The results revealed that emodin markedly improved pancreatic histological injury and decreased the levels of serum amylase, IL-1beta and IL-18.	Emodin	26-32	interleukin 1 alpha	Rattus norvegicus	125-133
34178130-10	2021	The results revealed that emodin markedly improved pancreatic histological injury and decreased the levels of serum amylase, IL-1beta and IL-18.	Emodin	26-32	interleukin 18	Rattus norvegicus	138-143
34178130-12	2021	Additionally, the protein expression levels of intercellular adhesion molecule 1, NLRP3, apoptosis-associated speck-like protein containing a CARD and cleaved caspase-1 were downregulated following emodin treatment.	Emodin	198-204	intercellular adhesion molecule 1	Rattus norvegicus	47-80
34178130-12	2021	Additionally, the protein expression levels of intercellular adhesion molecule 1, NLRP3, apoptosis-associated speck-like protein containing a CARD and cleaved caspase-1 were downregulated following emodin treatment.	Emodin	198-204	NLR family, pyrin domain containing 3	Mus musculus	82-87
34178130-12	2021	Additionally, the protein expression levels of intercellular adhesion molecule 1, NLRP3, apoptosis-associated speck-like protein containing a CARD and cleaved caspase-1 were downregulated following emodin treatment.	Emodin	198-204	PYD and CARD domain containing	Rattus norvegicus	89-146
34178130-12	2021	Additionally, the protein expression levels of intercellular adhesion molecule 1, NLRP3, apoptosis-associated speck-like protein containing a CARD and cleaved caspase-1 were downregulated following emodin treatment.	Emodin	198-204	caspase 1	Rattus norvegicus	159-168
34178130-14	2021	The present study demonstrated that emodin may offer protection against ALI induced by SAP via inhibiting and suppressing NLRP3 inflammasome-mediated neutrophil recruitment and may be a novel therapeutic strategy for the clinical treatment of ALI.	Emodin	36-42	NLR family, pyrin domain containing 3	Mus musculus	122-127
34116735-0	2021	Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-beta1 in renal fibrosis.	Emodin	0-6	bone morphogenetic protein 7	Rattus norvegicus	97-102
34116735-0	2021	Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-beta1 in renal fibrosis.	Emodin	0-6	transforming growth factor, beta 1	Rattus norvegicus	103-112
34116735-8	2021	Upregulation of BMP-7 was recorded in the RF rats subjected to emodin treatment.	Emodin	63-69	bone morphogenetic protein 7	Rattus norvegicus	16-21
34116735-10	2021	The results revealed that the attenuation of EMT by emodin could be blocked after the inhibition of BMP-7 and suppression of autophagy.	Emodin	52-58	bone morphogenetic protein 7	Rattus norvegicus	100-105
34116735-11	2021	Our findings demonstrated that emodin alleviates EMT during RF by actuating autophagy through BMP-7, suggesting a role of BMP-7 in RF treatment and prevention.	Emodin	31-37	bone morphogenetic protein 7	Rattus norvegicus	94-99
34116735-11	2021	Our findings demonstrated that emodin alleviates EMT during RF by actuating autophagy through BMP-7, suggesting a role of BMP-7 in RF treatment and prevention.	Emodin	31-37	bone morphogenetic protein 7	Rattus norvegicus	122-127
34332565-11	2021	Furthermore, emodin-mediated effects on cell viability, migration, apoptosis and PI3K/Akt signaling activity of PASMCs under hypoxia were significantly attenuated by miR-244-5p knockdown.	Emodin	13-19	AKT serine/threonine kinase 1	Homo sapiens	86-89
34332565-12	2021	CONCLUSIONS: Our results indicated that emodin suppressed cell viability, proliferation and migration, promoted cell apoptosis of PASMCs under hypoxia via modulating miR-244-5p-mediated DEGS1/PI3K/Akt signaling pathway.	Emodin	40-46	delta 4-desaturase, sphingolipid 1	Homo sapiens	186-191
34332565-12	2021	CONCLUSIONS: Our results indicated that emodin suppressed cell viability, proliferation and migration, promoted cell apoptosis of PASMCs under hypoxia via modulating miR-244-5p-mediated DEGS1/PI3K/Akt signaling pathway.	Emodin	40-46	AKT serine/threonine kinase 1	Homo sapiens	197-200
34381778-12	2021	Two weeks later, emodin prevented the depression behaviors in DeS rats along with a series of pathological changes in their hippocampi, such as loss of neurons and spines, microglial activation, increased interleukin-1beta and tumor necrosis factor-alpha, and the activation of 5-LO.	Emodin	17-23	interleukin 1 beta	Rattus norvegicus	205-222
34381778-12	2021	Two weeks later, emodin prevented the depression behaviors in DeS rats along with a series of pathological changes in their hippocampi, such as loss of neurons and spines, microglial activation, increased interleukin-1beta and tumor necrosis factor-alpha, and the activation of 5-LO.	Emodin	17-23	tumor necrosis factor	Rattus norvegicus	227-254
34381778-13	2021	Furthermore, we demonstrated that emodin inhibited its excess inflammatory response, possibly by targeting miR-139-5p/5-LO and modulating glycogen synthase kinase 3beta and nuclear factor erythroid 2-related factor 2.	Emodin	34-40	glycogen synthase kinase 3 beta	Rattus norvegicus	138-168
34381778-13	2021	Furthermore, we demonstrated that emodin inhibited its excess inflammatory response, possibly by targeting miR-139-5p/5-LO and modulating glycogen synthase kinase 3beta and nuclear factor erythroid 2-related factor 2.	Emodin	34-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	173-216
34320121-0	2021	Emodin alleviates hypertrophic scar formation by suppressing macrophage polarization and inhibiting the Notch and TGF-beta pathways in macrophages.	Emodin	0-6	notch receptor 1	Rattus norvegicus	104-109
34320121-0	2021	Emodin alleviates hypertrophic scar formation by suppressing macrophage polarization and inhibiting the Notch and TGF-beta pathways in macrophages.	Emodin	0-6	transforming growth factor alpha	Rattus norvegicus	114-122
34320121-12	2021	Western blot and qPCR assays showed that Notch1, Notch4, Hes1, TGF-beta, and Smad3 were downregulated in response to emodin treatment.	Emodin	117-123	notch receptor 1	Rattus norvegicus	41-47
34320121-12	2021	Western blot and qPCR assays showed that Notch1, Notch4, Hes1, TGF-beta, and Smad3 were downregulated in response to emodin treatment.	Emodin	117-123	notch receptor 4	Rattus norvegicus	49-55
34320121-12	2021	Western blot and qPCR assays showed that Notch1, Notch4, Hes1, TGF-beta, and Smad3 were downregulated in response to emodin treatment.	Emodin	117-123	hes family bHLH transcription factor 1	Rattus norvegicus	57-61
34320121-12	2021	Western blot and qPCR assays showed that Notch1, Notch4, Hes1, TGF-beta, and Smad3 were downregulated in response to emodin treatment.	Emodin	117-123	transforming growth factor alpha	Rattus norvegicus	63-71
34320121-12	2021	Western blot and qPCR assays showed that Notch1, Notch4, Hes1, TGF-beta, and Smad3 were downregulated in response to emodin treatment.	Emodin	117-123	SMAD family member 3	Rattus norvegicus	77-82
34320121-13	2021	Taken together, our findings suggested that emodin attenuated HS formation and fibrosis by suppressing macrophage polarization, which is associated with the inhibition of the Notch and TGF-beta pathways in macrophages.	Emodin	44-50	notch receptor 1	Rattus norvegicus	175-180
34320121-13	2021	Taken together, our findings suggested that emodin attenuated HS formation and fibrosis by suppressing macrophage polarization, which is associated with the inhibition of the Notch and TGF-beta pathways in macrophages.	Emodin	44-50	transforming growth factor alpha	Rattus norvegicus	185-193
34306988-9	2021	Emodin showed best interactions with TMPRSS 2 and ACE2 with Etotal of -7.1 and -7.3 KJ mol-1 respectively, whereas artemisinin interacts with TMPRSS 2 and ACE2 with Etotal of -6.9 and -7.4 KJ mol-1 respectively.	Emodin	0-6	transmembrane serine protease 2	Homo sapiens	37-45
34306988-9	2021	Emodin showed best interactions with TMPRSS 2 and ACE2 with Etotal of -7.1 and -7.3 KJ mol-1 respectively, whereas artemisinin interacts with TMPRSS 2 and ACE2 with Etotal of -6.9 and -7.4 KJ mol-1 respectively.	Emodin	0-6	angiotensin converting enzyme 2	Homo sapiens	50-54
34257265-9	2021	Also, emodin significantly attenuated the lipid profiles and restored endothelial function, as reflected by upregulated expression of hepatic LDLR and p-eNOS, respectively.	Emodin	6-12	low density lipoprotein receptor	Rattus norvegicus	142-146
34257265-9	2021	Also, emodin significantly attenuated the lipid profiles and restored endothelial function, as reflected by upregulated expression of hepatic LDLR and p-eNOS, respectively.	Emodin	6-12	nitric oxide synthase 3	Rattus norvegicus	153-157
34359939-8	2021	Emodin, a CSNK2A1 inhibitor, potentiated the cytotoxic effects of doxorubicin in osteosarcoma cells.	Emodin	0-6	casein kinase 2 alpha 1	Homo sapiens	10-17
35567995-0	2022	ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin.	Emodin	74-80	acyl-CoA synthetase long chain family member 4	Homo sapiens	0-5
34345733-4	2021	Interestingly, among the mycotoxins investigated, aflatoxin G1 is seen to give the strongest stabilization energy while Zearalenone shows the highest tendency to accept electron(s) and emodin, an emerging mycotoxin gave the best binding pose within the androgen receptor pocket with a mean binding affinity of -7.40 kcal/mol.	Emodin	185-191	androgen receptor	Homo sapiens	253-270
34110631-11	2021	We further identified that TREM2 was the most dramatically upregulated molecule by emodin and emodin-induced M2 macrophage polarization was dependent on TREM2.	Emodin	83-89	triggering receptor expressed on myeloid cells 2	Mus musculus	27-32
34110631-11	2021	We further identified that TREM2 was the most dramatically upregulated molecule by emodin and emodin-induced M2 macrophage polarization was dependent on TREM2.	Emodin	94-100	triggering receptor expressed on myeloid cells 2	Mus musculus	27-32
34110631-11	2021	We further identified that TREM2 was the most dramatically upregulated molecule by emodin and emodin-induced M2 macrophage polarization was dependent on TREM2.	Emodin	94-100	triggering receptor expressed on myeloid cells 2	Mus musculus	153-158
34110631-12	2021	Furthermore, silencing TREM2 apparently abrogated the effect of emodin on AT inflammation and adipogenesis.	Emodin	64-70	triggering receptor expressed on myeloid cells 2	Mus musculus	23-28
34110631-13	2021	We, for the first time, disclosed that emodin inhibited obesity by promoting M2 macrophage polarization via TREM2, suggesting that emodin may be explored as a clinical and translational candidate in preventing obesity and its related metabolic diseases.	Emodin	39-45	triggering receptor expressed on myeloid cells 2	Mus musculus	108-113
34110631-13	2021	We, for the first time, disclosed that emodin inhibited obesity by promoting M2 macrophage polarization via TREM2, suggesting that emodin may be explored as a clinical and translational candidate in preventing obesity and its related metabolic diseases.	Emodin	131-137	triggering receptor expressed on myeloid cells 2	Mus musculus	108-113
34206896-8	2021	Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-alpha (p < 0.05) and IFN-beta expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect.	Emodin	27-33	toll like receptor 3	Homo sapiens	67-87
34206896-8	2021	Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-alpha (p < 0.05) and IFN-beta expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect.	Emodin	27-33	toll like receptor 3	Homo sapiens	89-93
34206896-8	2021	Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-alpha (p < 0.05) and IFN-beta expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect.	Emodin	27-33	interferon alpha 1	Homo sapiens	107-116
34206896-8	2021	Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-alpha (p < 0.05) and IFN-beta expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect.	Emodin	27-33	interferon alpha 1	Homo sapiens	132-140
34206896-8	2021	Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-alpha (p < 0.05) and IFN-beta expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect.	Emodin	27-33	toll like receptor 3	Homo sapiens	212-216
34206896-8	2021	Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-alpha (p < 0.05) and IFN-beta expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect.	Emodin	231-237	toll like receptor 3	Homo sapiens	67-87
34206896-8	2021	Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-alpha (p < 0.05) and IFN-beta expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect.	Emodin	231-237	toll like receptor 3	Homo sapiens	89-93
34206896-8	2021	Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-alpha (p < 0.05) and IFN-beta expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect.	Emodin	231-237	interferon alpha 1	Homo sapiens	107-116
34206896-8	2021	Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-alpha (p < 0.05) and IFN-beta expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect.	Emodin	231-237	interferon alpha 1	Homo sapiens	132-140
34206896-8	2021	Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-alpha (p < 0.05) and IFN-beta expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect.	Emodin	231-237	toll like receptor 3	Homo sapiens	212-216
34150656-0	2021	Corrigendum: Emodin Interferes With AKT1-Mediated DNA Damage and Decreases Resistance of Breast Cancer Cells to Doxorubicin.	Emodin	13-19	AKT serine/threonine kinase 1	Homo sapiens	36-40
34159197-11	2021	Results: Postprandial GLP-1 levels in plasma, as well as PPAR-gamma and GLP-1R, decreased in kidney tissue of HFD mice, while they were reserved by emodin treatment.	Emodin	148-154	glucagon-like peptide 1 receptor	Mus musculus	22-27
34159197-11	2021	Results: Postprandial GLP-1 levels in plasma, as well as PPAR-gamma and GLP-1R, decreased in kidney tissue of HFD mice, while they were reserved by emodin treatment.	Emodin	148-154	peroxisome proliferator activated receptor gamma	Mus musculus	57-67
34159197-11	2021	Results: Postprandial GLP-1 levels in plasma, as well as PPAR-gamma and GLP-1R, decreased in kidney tissue of HFD mice, while they were reserved by emodin treatment.	Emodin	148-154	glucagon-like peptide 1 receptor	Mus musculus	72-78
34159197-14	2021	Additionally, downregulation of PPAR-gamma and GLP-1R by palmitic acid was remanded by emodin.	Emodin	87-93	peroxisome proliferator activated receptor gamma	Mus musculus	32-42
34159197-14	2021	Additionally, downregulation of PPAR-gamma and GLP-1R by palmitic acid was remanded by emodin.	Emodin	87-93	glucagon-like peptide 1 receptor	Mus musculus	47-53
34159197-15	2021	Moreover, GW9662, an inhibitor of PPAR-gamma, abolished the protective effect of emodin.	Emodin	81-87	peroxisome proliferator activated receptor gamma	Mus musculus	34-44
34159197-16	2021	Conclusion: The kidney damage of HFD mice seems to be alleviated by emodin via the upregulation of GLP-1R in kidney tissue.	Emodin	68-74	glucagon-like peptide 1 receptor	Mus musculus	99-105
34151713-0	2021	Emodin alleviates high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation of mesangial cells by the circ_0000064/miR-30c-5p/Lmp7 axis.	Emodin	0-6	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	Mus musculus	158-162
34220500-10	2021	For instance, the AUC (0- ) values of the TSG prototype and its phase II metabolites were higher in the ANIT group, followed by CCl4 group and the normal group, while the AUC (0- ) values of the emodin prototype and its phase II metabolites were higher in the CCl4 group.	Emodin	195-201	C-C motif chemokine ligand 4	Rattus norvegicus	260-264
34159197-0	2021	Emodin Attenuated the Kidney Damage of High-Fat-Diet Mice via the Upregulation of Glucagon-Like Peptide-1 Receptor.	Emodin	0-6	glucagon-like peptide 1 receptor	Mus musculus	82-114
34159197-3	2021	We aim to explore the roles of the receptor of GLP-1 (GLP-1R) involved in high-fat-diet- (HFD-) induced kidney damage improved by emodin.	Emodin	130-136	glucagon-like peptide 1 receptor	Mus musculus	47-52
34159197-3	2021	We aim to explore the roles of the receptor of GLP-1 (GLP-1R) involved in high-fat-diet- (HFD-) induced kidney damage improved by emodin.	Emodin	130-136	glucagon-like peptide 1 receptor	Mus musculus	54-60
35567995-9	2022	A docking simulation assay and an MST assay were performed to explore the potential mode of emodin binding to ACSL4.	Emodin	92-98	acyl-CoA synthetase long chain family member 4	Homo sapiens	110-115
35567995-14	2022	Docking simulation and MST assay confirmed that emodin can directly bind to ACSL4 target.	Emodin	48-54	acyl-CoA synthetase long chain family member 4	Homo sapiens	76-81
35567995-15	2022	Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion.	Emodin	66-72	acyl-CoA synthetase long chain family member 4	Homo sapiens	10-15
35567995-15	2022	Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion.	Emodin	66-72	vascular endothelial growth factor A	Homo sapiens	76-80
35567995-15	2022	Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion.	Emodin	66-72	fms related receptor tyrosine kinase 1	Homo sapiens	95-101
35567995-15	2022	Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion.	Emodin	66-72	kinase insert domain receptor	Homo sapiens	106-112
35567995-15	2022	Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion.	Emodin	66-72	acyl-CoA synthetase long chain family member 4	Homo sapiens	212-217
35567995-15	2022	Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion.	Emodin	66-72	vascular endothelial growth factor A	Homo sapiens	233-237
35567995-15	2022	Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion.	Emodin	202-208	acyl-CoA synthetase long chain family member 4	Homo sapiens	10-15
35567995-17	2022	CONCLUSION: Our findings indicate that emodin inhibits proliferation and invasion of CRC cells and reduces VEGF secretion and VEGFR1 and VEGFR2 expression by inhibiting ACSL4.	Emodin	39-45	vascular endothelial growth factor A	Mus musculus	107-111
35567995-17	2022	CONCLUSION: Our findings indicate that emodin inhibits proliferation and invasion of CRC cells and reduces VEGF secretion and VEGFR1 and VEGFR2 expression by inhibiting ACSL4.	Emodin	39-45	FMS-like tyrosine kinase 1	Mus musculus	126-132
35567995-17	2022	CONCLUSION: Our findings indicate that emodin inhibits proliferation and invasion of CRC cells and reduces VEGF secretion and VEGFR1 and VEGFR2 expression by inhibiting ACSL4.	Emodin	39-45	kinase insert domain protein receptor	Mus musculus	137-143
35567995-17	2022	CONCLUSION: Our findings indicate that emodin inhibits proliferation and invasion of CRC cells and reduces VEGF secretion and VEGFR1 and VEGFR2 expression by inhibiting ACSL4.	Emodin	39-45	acyl-CoA synthetase long-chain family member 4	Mus musculus	169-174
35421539-0	2022	Structural and mechanistic insights into modulation of alpha-Synuclein fibril formation by aloin and emodin.	Emodin	101-107	synuclein alpha	Homo sapiens	55-70
35313287-4	2022	Herein, the amphiphilic block copolymer CD44-targeting peptide-conjugated polyethylene glycol - block  hydroxyethyl starch-block-poly (L-lactic acid) (CD44p-conjugated PEG-b-HES-b-PLA) was synthesized and self-assembled to form pH-responsive and Emo-loaded polymeric micelles (Emo@CD44p-PM) to target breast cancer.	Emodin	246-249	CD44 molecule (Indian blood group)	Homo sapiens	40-44
35421539-3	2022	In this study, we have shown modulation, disaggregation, and neuroprotective potential of aloin and emodin against alpha-Syn aggregation/fibrillation.	Emodin	100-106	synuclein alpha	Homo sapiens	115-124
35421539-10	2022	These findings provide deep insight into the modulatory mechanism of alpha-Syn aggregation/fibrillation in the presence of aloin and emodin, thereby suggesting their potential roles as promising therapeutic molecules against aggregation/fibrillation related disorders.	Emodin	133-139	synuclein alpha	Homo sapiens	69-78
35521627-3	2022	By contrast, the cutoff value for emodin was 2,000 ng mL-1.	Emodin	34-40	L1 cell adhesion molecule	Mus musculus	54-58
35313287-4	2022	Herein, the amphiphilic block copolymer CD44-targeting peptide-conjugated polyethylene glycol - block  hydroxyethyl starch-block-poly (L-lactic acid) (CD44p-conjugated PEG-b-HES-b-PLA) was synthesized and self-assembled to form pH-responsive and Emo-loaded polymeric micelles (Emo@CD44p-PM) to target breast cancer.	Emodin	277-280	CD44 molecule (Indian blood group)	Homo sapiens	40-44
35313287-8	2022	Once the polymeric micelles Emo@CD44p-PM entered acidic tumor microenvironment (pH<6.8), the acid-labile acetal bond hydrolyses gradually and led to the detachment of PEG layer, which resulted in the exposure of CD44p to enhance the cellular internalization of Emo@CD44p-PM effectively.	Emodin	28-31	CD44 molecule (Indian blood group)	Homo sapiens	32-37
35313287-8	2022	Once the polymeric micelles Emo@CD44p-PM entered acidic tumor microenvironment (pH<6.8), the acid-labile acetal bond hydrolyses gradually and led to the detachment of PEG layer, which resulted in the exposure of CD44p to enhance the cellular internalization of Emo@CD44p-PM effectively.	Emodin	28-31	CD44 molecule (Indian blood group)	Homo sapiens	212-217
35313287-8	2022	Once the polymeric micelles Emo@CD44p-PM entered acidic tumor microenvironment (pH<6.8), the acid-labile acetal bond hydrolyses gradually and led to the detachment of PEG layer, which resulted in the exposure of CD44p to enhance the cellular internalization of Emo@CD44p-PM effectively.	Emodin	261-264	CD44 molecule (Indian blood group)	Homo sapiens	32-37
35313287-8	2022	Once the polymeric micelles Emo@CD44p-PM entered acidic tumor microenvironment (pH<6.8), the acid-labile acetal bond hydrolyses gradually and led to the detachment of PEG layer, which resulted in the exposure of CD44p to enhance the cellular internalization of Emo@CD44p-PM effectively.	Emodin	261-264	CD44 molecule (Indian blood group)	Homo sapiens	212-217
35370650-12	2022	Moreover, the inhibitory effect of emodin on c-Jun can be attenuated by Nur77 siRNA.	Emodin	35-41	jun proto-oncogene	Mus musculus	45-50
35406121-0	2022	Polygonum cuspidatum Extract (Pc-Ex) Containing Emodin Suppresses Lung Cancer-Induced Cachexia by Suppressing TCF4/TWIST1 Complex-Induced PTHrP Expression.	Emodin	48-54	transcription factor 4	Mus musculus	110-114
35406121-0	2022	Polygonum cuspidatum Extract (Pc-Ex) Containing Emodin Suppresses Lung Cancer-Induced Cachexia by Suppressing TCF4/TWIST1 Complex-Induced PTHrP Expression.	Emodin	48-54	twist basic helix-loop-helix transcription factor 1	Mus musculus	115-121
35406121-6	2022	The results of the mammalian two-hybrid luciferase assay revealed that emodin inhibited TCF4-TWIST1 interaction.	Emodin	71-77	transcription factor 4	Homo sapiens	88-92
35406121-6	2022	The results of the mammalian two-hybrid luciferase assay revealed that emodin inhibited TCF4-TWIST1 interaction.	Emodin	71-77	twist family bHLH transcription factor 1	Homo sapiens	93-99
35406121-11	2022	Emodin inhibited the interaction between TCF4 and TWIST1 and consequently suppressed the TCF4/TWIST1 complex-induced upregulated mRNA and protein levels of PTHLH and PTHrP.	Emodin	0-6	transcription factor 4	Mus musculus	41-45
35406121-11	2022	Emodin inhibited the interaction between TCF4 and TWIST1 and consequently suppressed the TCF4/TWIST1 complex-induced upregulated mRNA and protein levels of PTHLH and PTHrP.	Emodin	0-6	twist basic helix-loop-helix transcription factor 1	Mus musculus	50-56
35406121-11	2022	Emodin inhibited the interaction between TCF4 and TWIST1 and consequently suppressed the TCF4/TWIST1 complex-induced upregulated mRNA and protein levels of PTHLH and PTHrP.	Emodin	0-6	transcription factor 4	Mus musculus	89-93
35406121-11	2022	Emodin inhibited the interaction between TCF4 and TWIST1 and consequently suppressed the TCF4/TWIST1 complex-induced upregulated mRNA and protein levels of PTHLH and PTHrP.	Emodin	0-6	twist basic helix-loop-helix transcription factor 1	Mus musculus	94-100
35406121-13	2022	Emodin-containing Pc-Ex exerted therapeutic effects on lung cancer-associated cachexia by inhibiting TCF4/TWIST1 complex-induced PTHrP expression.	Emodin	0-6	transcription factor 4	Mus musculus	101-105
35406121-13	2022	Emodin-containing Pc-Ex exerted therapeutic effects on lung cancer-associated cachexia by inhibiting TCF4/TWIST1 complex-induced PTHrP expression.	Emodin	0-6	twist basic helix-loop-helix transcription factor 1	Mus musculus	106-112
35387564-0	2022	Emodin suppresses hepatocellular carcinoma growth by regulating macrophage polarization via microRNA-26a/transforming growth factor beta 1/protein kinase B.	Emodin	0-6	protein tyrosine kinase 2 beta	Homo sapiens	139-155
35387564-6	2022	Based on bioinformatics analysis and in vitro validation, it was found that the effect of emodin on M2 polarization was regulated by the microRNA-26a (miR-26)/Transforming growth factor beta 1 (TGF-beta1)/Protein kinase B (Akt) axis.	Emodin	90-96	transforming growth factor beta 1	Homo sapiens	159-192
35387564-6	2022	Based on bioinformatics analysis and in vitro validation, it was found that the effect of emodin on M2 polarization was regulated by the microRNA-26a (miR-26)/Transforming growth factor beta 1 (TGF-beta1)/Protein kinase B (Akt) axis.	Emodin	90-96	transforming growth factor beta 1	Homo sapiens	194-203
35387564-6	2022	Based on bioinformatics analysis and in vitro validation, it was found that the effect of emodin on M2 polarization was regulated by the microRNA-26a (miR-26)/Transforming growth factor beta 1 (TGF-beta1)/Protein kinase B (Akt) axis.	Emodin	90-96	protein tyrosine kinase 2 beta	Homo sapiens	205-221
35387564-6	2022	Based on bioinformatics analysis and in vitro validation, it was found that the effect of emodin on M2 polarization was regulated by the microRNA-26a (miR-26)/Transforming growth factor beta 1 (TGF-beta1)/Protein kinase B (Akt) axis.	Emodin	90-96	AKT serine/threonine kinase 1	Homo sapiens	223-226
35387564-8	2022	Western blot analysis on xenografts confirmed that emodin could induce transformation of M2 to M1 macrophages and reverse the up-regulation of PCNA, TGF-beta1, and p-Akt induced by M2 macrophages.	Emodin	51-57	proliferating cell nuclear antigen	Homo sapiens	143-147
35387564-8	2022	Western blot analysis on xenografts confirmed that emodin could induce transformation of M2 to M1 macrophages and reverse the up-regulation of PCNA, TGF-beta1, and p-Akt induced by M2 macrophages.	Emodin	51-57	transforming growth factor beta 1	Homo sapiens	149-158
35387564-8	2022	Western blot analysis on xenografts confirmed that emodin could induce transformation of M2 to M1 macrophages and reverse the up-regulation of PCNA, TGF-beta1, and p-Akt induced by M2 macrophages.	Emodin	51-57	AKT serine/threonine kinase 1	Homo sapiens	166-169
35387564-9	2022	In summary, our findings uncover a novel mechanism behind the anti-tumor effects of emodin that regulates M2 polarization via miR-26a/TGF-beta1/Akt to suppress HCC growth.	Emodin	84-90	microRNA 26a-1	Homo sapiens	126-133
35387564-9	2022	In summary, our findings uncover a novel mechanism behind the anti-tumor effects of emodin that regulates M2 polarization via miR-26a/TGF-beta1/Akt to suppress HCC growth.	Emodin	84-90	transforming growth factor beta 1	Homo sapiens	134-143
35387564-9	2022	In summary, our findings uncover a novel mechanism behind the anti-tumor effects of emodin that regulates M2 polarization via miR-26a/TGF-beta1/Akt to suppress HCC growth.	Emodin	84-90	AKT serine/threonine kinase 1	Homo sapiens	144-147
35370650-0	2022	Emodin Protects Against Lipopolysaccharide-Induced Acute Lung Injury via the JNK/Nur77/c-Jun Signaling Pathway.	Emodin	0-6	mitogen-activated protein kinase 8	Mus musculus	77-80
35370650-0	2022	Emodin Protects Against Lipopolysaccharide-Induced Acute Lung Injury via the JNK/Nur77/c-Jun Signaling Pathway.	Emodin	0-6	nuclear receptor subfamily 4, group A, member 1	Mus musculus	81-86
35370650-0	2022	Emodin Protects Against Lipopolysaccharide-Induced Acute Lung Injury via the JNK/Nur77/c-Jun Signaling Pathway.	Emodin	0-6	jun proto-oncogene	Mus musculus	87-92
35370650-10	2022	Emodin suppressed the expression levels of phosphorylated JNK at Thr183/tyr182 and phosphorylated Nur77 at Ser351 and c-Jun, and increased the expression level of Nur77 in LPS-stimulated RAW264.7 cells, while these regulatory effects of emodin on Nur77/c-Jun were counteracted by JNK activators.	Emodin	0-6	mitogen-activated protein kinase 8	Mus musculus	58-61
35370650-10	2022	Emodin suppressed the expression levels of phosphorylated JNK at Thr183/tyr182 and phosphorylated Nur77 at Ser351 and c-Jun, and increased the expression level of Nur77 in LPS-stimulated RAW264.7 cells, while these regulatory effects of emodin on Nur77/c-Jun were counteracted by JNK activators.	Emodin	0-6	nuclear receptor subfamily 4, group A, member 1	Mus musculus	98-103
35370650-10	2022	Emodin suppressed the expression levels of phosphorylated JNK at Thr183/tyr182 and phosphorylated Nur77 at Ser351 and c-Jun, and increased the expression level of Nur77 in LPS-stimulated RAW264.7 cells, while these regulatory effects of emodin on Nur77/c-Jun were counteracted by JNK activators.	Emodin	0-6	jun proto-oncogene	Mus musculus	118-123
35370650-10	2022	Emodin suppressed the expression levels of phosphorylated JNK at Thr183/tyr182 and phosphorylated Nur77 at Ser351 and c-Jun, and increased the expression level of Nur77 in LPS-stimulated RAW264.7 cells, while these regulatory effects of emodin on Nur77/c-Jun were counteracted by JNK activators.	Emodin	0-6	nuclear receptor subfamily 4, group A, member 1	Mus musculus	163-168
35370650-10	2022	Emodin suppressed the expression levels of phosphorylated JNK at Thr183/tyr182 and phosphorylated Nur77 at Ser351 and c-Jun, and increased the expression level of Nur77 in LPS-stimulated RAW264.7 cells, while these regulatory effects of emodin on Nur77/c-Jun were counteracted by JNK activators.	Emodin	0-6	nuclear receptor subfamily 4, group A, member 1	Mus musculus	247-252
35370650-10	2022	Emodin suppressed the expression levels of phosphorylated JNK at Thr183/tyr182 and phosphorylated Nur77 at Ser351 and c-Jun, and increased the expression level of Nur77 in LPS-stimulated RAW264.7 cells, while these regulatory effects of emodin on Nur77/c-Jun were counteracted by JNK activators.	Emodin	0-6	jun proto-oncogene	Mus musculus	253-258
35370650-10	2022	Emodin suppressed the expression levels of phosphorylated JNK at Thr183/tyr182 and phosphorylated Nur77 at Ser351 and c-Jun, and increased the expression level of Nur77 in LPS-stimulated RAW264.7 cells, while these regulatory effects of emodin on Nur77/c-Jun were counteracted by JNK activators.	Emodin	0-6	mitogen-activated protein kinase 8	Mus musculus	280-283
35370650-12	2022	Moreover, the inhibitory effect of emodin on c-Jun can be attenuated by Nur77 siRNA.	Emodin	35-41	nuclear receptor subfamily 4, group A, member 1	Mus musculus	72-77
35370650-13	2022	Furthermore, emodin alleviated LPS-induced ALI in mice through the regulation of the JNK/Nur77/c-Jun pathway.	Emodin	13-19	mitogen-activated protein kinase 8	Mus musculus	85-88
35370650-13	2022	Furthermore, emodin alleviated LPS-induced ALI in mice through the regulation of the JNK/Nur77/c-Jun pathway.	Emodin	13-19	nuclear receptor subfamily 4, group A, member 1	Mus musculus	89-94
35370650-13	2022	Furthermore, emodin alleviated LPS-induced ALI in mice through the regulation of the JNK/Nur77/c-Jun pathway.	Emodin	13-19	jun proto-oncogene	Mus musculus	95-100
35370650-14	2022	Conclusions: Emodin protects against LPS-induced ALI through regulation on JNK/Nur77/c-Jun signaling.	Emodin	13-19	mitogen-activated protein kinase 8	Mus musculus	75-78
35370650-14	2022	Conclusions: Emodin protects against LPS-induced ALI through regulation on JNK/Nur77/c-Jun signaling.	Emodin	13-19	nuclear receptor subfamily 4, group A, member 1	Mus musculus	79-84
35370650-14	2022	Conclusions: Emodin protects against LPS-induced ALI through regulation on JNK/Nur77/c-Jun signaling.	Emodin	13-19	jun proto-oncogene	Mus musculus	85-90
35018819-9	2022	However, there was a significant increase in NOS2 expression (M1 marker) in mice treated with 80 mg/kg emodin (p<0.05).	Emodin	103-109	nitric oxide synthase 2, inducible	Mus musculus	45-49
35272197-7	2022	Our data proved the AhR-IL24 signal axis is an important pathway for emodin to inhibit the migration of glioblastoma, and the AhR signaling pathway can be used as a key target to research the regulation effect and its mechanism of compounds on glioblastoma migration.	Emodin	69-75	aryl hydrocarbon receptor	Homo sapiens	126-129
35246004-0	2022	Emodin relieves the inflammation and pyroptosis of lipopolysaccharide-treated 1321N1 cells by regulating methyltransferase-like 3 -mediated NLR family pyrin domain containing 3 expression.	Emodin	0-6	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	105-129
35246004-0	2022	Emodin relieves the inflammation and pyroptosis of lipopolysaccharide-treated 1321N1 cells by regulating methyltransferase-like 3 -mediated NLR family pyrin domain containing 3 expression.	Emodin	0-6	NLR family pyrin domain containing 3	Homo sapiens	140-176
35246004-11	2022	Emodin treatment decreased the levels of TNF-alpha, IL-1beta, IL-6, NLRP3, SDC-1, GSDMD-N, and Caspase-1, while increasing the levels of IL-10 in LPS-treated 1321N1 cells.	Emodin	0-6	tumor necrosis factor	Homo sapiens	41-50
35246004-11	2022	Emodin treatment decreased the levels of TNF-alpha, IL-1beta, IL-6, NLRP3, SDC-1, GSDMD-N, and Caspase-1, while increasing the levels of IL-10 in LPS-treated 1321N1 cells.	Emodin	0-6	interleukin 1 alpha	Homo sapiens	52-60
35246004-11	2022	Emodin treatment decreased the levels of TNF-alpha, IL-1beta, IL-6, NLRP3, SDC-1, GSDMD-N, and Caspase-1, while increasing the levels of IL-10 in LPS-treated 1321N1 cells.	Emodin	0-6	interleukin 6	Homo sapiens	62-66
35246004-11	2022	Emodin treatment decreased the levels of TNF-alpha, IL-1beta, IL-6, NLRP3, SDC-1, GSDMD-N, and Caspase-1, while increasing the levels of IL-10 in LPS-treated 1321N1 cells.	Emodin	0-6	NLR family pyrin domain containing 3	Homo sapiens	68-73
35246004-11	2022	Emodin treatment decreased the levels of TNF-alpha, IL-1beta, IL-6, NLRP3, SDC-1, GSDMD-N, and Caspase-1, while increasing the levels of IL-10 in LPS-treated 1321N1 cells.	Emodin	0-6	syndecan 1	Homo sapiens	75-80
35246004-11	2022	Emodin treatment decreased the levels of TNF-alpha, IL-1beta, IL-6, NLRP3, SDC-1, GSDMD-N, and Caspase-1, while increasing the levels of IL-10 in LPS-treated 1321N1 cells.	Emodin	0-6	caspase 1	Homo sapiens	95-104
35246004-11	2022	Emodin treatment decreased the levels of TNF-alpha, IL-1beta, IL-6, NLRP3, SDC-1, GSDMD-N, and Caspase-1, while increasing the levels of IL-10 in LPS-treated 1321N1 cells.	Emodin	0-6	interleukin 10	Homo sapiens	137-142
35246004-15	2022	Therefore, emodin inhibits the inflammation and pyroptosis of LPS-treated 1321N1 cells by inactivating METTL3-mediated NLRP3 expression.	Emodin	11-17	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	103-109
35246004-15	2022	Therefore, emodin inhibits the inflammation and pyroptosis of LPS-treated 1321N1 cells by inactivating METTL3-mediated NLRP3 expression.	Emodin	11-17	NLR family pyrin domain containing 3	Homo sapiens	119-124
35272197-0	2022	Emodin inhibits U87 glioblastoma cells migration by activating aryl hydrocarbon receptor (AhR) signaling pathway.	Emodin	0-6	small nucleolar RNA, C/D box 87	Homo sapiens	16-19
35272197-0	2022	Emodin inhibits U87 glioblastoma cells migration by activating aryl hydrocarbon receptor (AhR) signaling pathway.	Emodin	0-6	aryl hydrocarbon receptor	Homo sapiens	63-88
35272197-0	2022	Emodin inhibits U87 glioblastoma cells migration by activating aryl hydrocarbon receptor (AhR) signaling pathway.	Emodin	0-6	aryl hydrocarbon receptor	Homo sapiens	90-93
35272197-2	2022	Although it has been reported that AhR agonist emodin can suppress some kinds of tumors, its inhibitory effect on glioblastoma migration and its relationship with AhR remain unclear.	Emodin	47-53	aryl hydrocarbon receptor	Homo sapiens	35-38
35272197-3	2022	Based on the complexity of tumor pathogenesis and the tissue specificity of AhR, we hope can further understand the effect of emodin on glioblastoma and explore its mechanism.	Emodin	126-132	aryl hydrocarbon receptor	Homo sapiens	76-79
35272197-4	2022	We found that the inhibitory effect of emodin on the migration of U87 glioblastoma cells increased with time, and the cell migration ability was inhibited by about 25% after 36 h exposure.	Emodin	39-45	small nucleolar RNA, C/D box 87	Homo sapiens	66-69
35272197-5	2022	In this process, emodin promoted the expression of the tumor suppressor IL24 by activating the AhR signaling pathway.	Emodin	17-23	interleukin 24	Homo sapiens	72-76
35272197-5	2022	In this process, emodin promoted the expression of the tumor suppressor IL24 by activating the AhR signaling pathway.	Emodin	17-23	aryl hydrocarbon receptor	Homo sapiens	95-98
35272197-6	2022	Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis.	Emodin	106-112	aryl hydrocarbon receptor	Homo sapiens	27-30
35272197-6	2022	Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis.	Emodin	106-112	interleukin 24	Homo sapiens	34-38
35272197-6	2022	Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis.	Emodin	106-112	small nucleolar RNA, C/D box 87	Homo sapiens	120-123
35272197-6	2022	Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis.	Emodin	106-112	aryl hydrocarbon receptor	Homo sapiens	234-237
35272197-6	2022	Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis.	Emodin	106-112	interleukin 24	Homo sapiens	238-242
35272197-6	2022	Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis.	Emodin	175-181	aryl hydrocarbon receptor	Homo sapiens	27-30
35272197-6	2022	Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis.	Emodin	175-181	interleukin 24	Homo sapiens	34-38
35272197-6	2022	Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis.	Emodin	175-181	small nucleolar RNA, C/D box 87	Homo sapiens	120-123
35272197-6	2022	Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis.	Emodin	175-181	aryl hydrocarbon receptor	Homo sapiens	234-237
35272197-6	2022	Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis.	Emodin	175-181	interleukin 24	Homo sapiens	238-242
35272197-7	2022	Our data proved the AhR-IL24 signal axis is an important pathway for emodin to inhibit the migration of glioblastoma, and the AhR signaling pathway can be used as a key target to research the regulation effect and its mechanism of compounds on glioblastoma migration.	Emodin	69-75	aryl hydrocarbon receptor	Homo sapiens	20-23
35272197-7	2022	Our data proved the AhR-IL24 signal axis is an important pathway for emodin to inhibit the migration of glioblastoma, and the AhR signaling pathway can be used as a key target to research the regulation effect and its mechanism of compounds on glioblastoma migration.	Emodin	69-75	interleukin 24	Homo sapiens	24-28
35210751-0	2022	Erratum: Emodin-Induced Autophagy Against Cell Apoptosis Through the PI3K/AKT/mTOR Pathway in Human Hepatocytes (Corrigendum).	Emodin	9-15	AKT serine/threonine kinase 1	Homo sapiens	74-77
35154426-4	2022	In addition, emodin inhibited the migration and invasion abilities of the ovarian cancer cells by inhibiting epithelial-mesenchymal transition (EMT), which was evidenced by the downregulation of N-cadherin and vimentin, and the upregulation of E-cadherin protein expression levels.	Emodin	13-19	cadherin 2	Mus musculus	195-205
35154426-4	2022	In addition, emodin inhibited the migration and invasion abilities of the ovarian cancer cells by inhibiting epithelial-mesenchymal transition (EMT), which was evidenced by the downregulation of N-cadherin and vimentin, and the upregulation of E-cadherin protein expression levels.	Emodin	13-19	vimentin	Mus musculus	210-218
35154426-4	2022	In addition, emodin inhibited the migration and invasion abilities of the ovarian cancer cells by inhibiting epithelial-mesenchymal transition (EMT), which was evidenced by the downregulation of N-cadherin and vimentin, and the upregulation of E-cadherin protein expression levels.	Emodin	13-19	cadherin 1	Mus musculus	244-254
35154426-6	2022	Furthermore, mechanical analysis revealed that emodin markedly inhibited EMT and reduced the stemness of tumor cells, which was evidenced by the decrease in the protein expression of CD133 and Oct4.	Emodin	47-53	prominin 1	Mus musculus	183-188
35154426-6	2022	Furthermore, mechanical analysis revealed that emodin markedly inhibited EMT and reduced the stemness of tumor cells, which was evidenced by the decrease in the protein expression of CD133 and Oct4.	Emodin	47-53	POU domain, class 5, transcription factor 1	Mus musculus	193-197
35210751-0	2022	Erratum: Emodin-Induced Autophagy Against Cell Apoptosis Through the PI3K/AKT/mTOR Pathway in Human Hepatocytes (Corrigendum).	Emodin	9-15	mechanistic target of rapamycin kinase	Homo sapiens	78-82
35123524-0	2022	Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA pathway.	Emodin	35-41	vasoactive intestinal peptide	Rattus norvegicus	140-143
35197857-0	2022	Emodin Protects SH-SY5Y Cells Against Zinc-Induced Synaptic Impairment and Oxidative Stress Through the ERK1/2 Pathway.	Emodin	0-6	mitogen-activated protein kinase 3	Homo sapiens	104-110
35197857-3	2022	We hypothesized that natural anthraquinone derivative emodin can protect against neurotoxicity induced by pathological concentrations of zinc via the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and alleviate oxidative stress and mitochondrial dysfunction.	Emodin	54-60	mitogen-activated protein kinase 1	Homo sapiens	150-191
35197857-3	2022	We hypothesized that natural anthraquinone derivative emodin can protect against neurotoxicity induced by pathological concentrations of zinc via the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and alleviate oxidative stress and mitochondrial dysfunction.	Emodin	54-60	mitogen-activated protein kinase 3	Homo sapiens	193-199
35197857-4	2022	Human neuroblastoma (SH-SY5Y 26 cells) was treated with zinc sulfate and different concentrations of emodin, and changes in the levels of ETK1/2 expression, oxidative stress (DCFH-DA staining), mitochondrial function (JC-1 staining), lipid peroxidation (4-hydroxynonenal staining), and DNA oxidation (8-hydroxy-2-deoxyguanosine staining) were examined.	Emodin	101-107	EPH receptor A3	Homo sapiens	138-144
35197857-5	2022	Emodin ameliorated zinc-induced altered expression of levels of phosphorylated ERK1/2 (not total ETK1/2) and synaptic proteins (presynaptic SNAP 25, synaptophysin and postsynaptic PSD95) in SH-SY5Y cells.	Emodin	0-6	mitogen-activated protein kinase 3	Homo sapiens	79-85
35197857-5	2022	Emodin ameliorated zinc-induced altered expression of levels of phosphorylated ERK1/2 (not total ETK1/2) and synaptic proteins (presynaptic SNAP 25, synaptophysin and postsynaptic PSD95) in SH-SY5Y cells.	Emodin	0-6	synaptosome associated protein 25	Homo sapiens	140-147
35197857-5	2022	Emodin ameliorated zinc-induced altered expression of levels of phosphorylated ERK1/2 (not total ETK1/2) and synaptic proteins (presynaptic SNAP 25, synaptophysin and postsynaptic PSD95) in SH-SY5Y cells.	Emodin	0-6	synaptophysin	Homo sapiens	149-162
35197857-5	2022	Emodin ameliorated zinc-induced altered expression of levels of phosphorylated ERK1/2 (not total ETK1/2) and synaptic proteins (presynaptic SNAP 25, synaptophysin and postsynaptic PSD95) in SH-SY5Y cells.	Emodin	0-6	discs large MAGUK scaffold protein 4	Homo sapiens	180-185
35197857-7	2022	In conclusion, our results indicated that emodin exerts neuroprotective effects against zinc by normalizing synaptic impairment by decreasing the phosphorylation of ERK1/2, reducing reactive oxygen species and protecting mitochondrial function.	Emodin	42-48	mitogen-activated protein kinase 3	Homo sapiens	165-171
35123524-14	2022	Pseudoephedrine + emodin treatment effectively promoted VIP cAMP and p-PKA protein expression in lung tissues, and significantly inhibited NF-kappaB, MAPK phosphorylation, Pseudoephedrine + emodin treatment can inhibit M1 polarization and promoted M2 polarization via the VIP/cAMP/PKA signaling pathway.	Emodin	18-24	vasoactive intestinal peptide	Rattus norvegicus	56-59
35123524-14	2022	Pseudoephedrine + emodin treatment effectively promoted VIP cAMP and p-PKA protein expression in lung tissues, and significantly inhibited NF-kappaB, MAPK phosphorylation, Pseudoephedrine + emodin treatment can inhibit M1 polarization and promoted M2 polarization via the VIP/cAMP/PKA signaling pathway.	Emodin	18-24	vasoactive intestinal peptide	Rattus norvegicus	272-275
35123524-15	2022	CONCLUSIONS: The combination of Pseudoephedrine and emodin was effective in ameliorating LPS-induced ALI in rats by inducing VIP/cAMP/PKA signaling.	Emodin	52-58	vasoactive intestinal peptide	Rattus norvegicus	125-128
35095071-1	2022	The editorial office of International Heart Journal would like to inform our readers that the experimental study titled "Emodin Attenuates Lipopolysaccharide-Induced Injury via Down-Regulation of miR-223 in H9c2 Cells" written by Yuping Yang, Zijun Jiang, Dong Zhuge and published in the March 2019 issue of International Heart Journal (Int Heart J 2019; 60: 436-443) has been retracted upon request from the authors.	Emodin	121-127	microRNA 223	Rattus norvegicus	196-203
34041746-0	2021	Effects of emodin, a plant-derived anthraquinone, on TGF-beta1-induced cardiac fibroblast activation and function.	Emodin	11-17	transforming growth factor beta 1	Homo sapiens	53-62
33731310-14	2021	Baicalin, emodin, and magnolol, the top 3 active components of CQCQD identified via pharmacology network analysis, suppressed NK1R internalization and NF-kappaB signal pathway activation in isolated pancreatic acinar cells.	Emodin	10-16	tachykinin receptor 1	Homo sapiens	126-130
34051074-7	2021	The molecular docking analysis revealed that EMO might have a strong combination with ESR1, AKT1 and GSK3B.	Emodin	45-48	estrogen receptor 1	Rattus norvegicus	86-90
34051074-7	2021	The molecular docking analysis revealed that EMO might have a strong combination with ESR1, AKT1 and GSK3B.	Emodin	45-48	AKT serine/threonine kinase 1	Rattus norvegicus	92-96
34051074-7	2021	The molecular docking analysis revealed that EMO might have a strong combination with ESR1, AKT1 and GSK3B.	Emodin	45-48	glycogen synthase kinase 3 beta	Rattus norvegicus	101-106
34051074-8	2021	Immunohistochemical staining and Western blotting showed that 2 weeks" EMO treatment (80 mg/kg/day) reduced depression related microglial activation, neuroinflammation and altered PI3K-Akt signaling pathway.	Emodin	71-74	AKT serine/threonine kinase 1	Rattus norvegicus	185-188
34041746-7	2021	We demonstrate that emodin attenuates TGF-beta1-induced fibroblast activation and collagen accumulation in vitro.	Emodin	20-26	transforming growth factor beta 1	Homo sapiens	38-47
34041746-6	2021	In the present study, experiments were performed to evaluate the effects of emodin on activation and function of cardiac fibroblasts following treatment with TGF-beta1.	Emodin	76-82	transforming growth factor beta 1	Homo sapiens	158-167
34041746-8	2021	Emodin also inhibits activation of several canonical (SMAD2/3) and noncanonical (Erk1/2) TGF-beta signaling pathways, while activating the p38 pathway.	Emodin	0-6	SMAD family member 2	Homo sapiens	54-61
34041746-8	2021	Emodin also inhibits activation of several canonical (SMAD2/3) and noncanonical (Erk1/2) TGF-beta signaling pathways, while activating the p38 pathway.	Emodin	0-6	mitogen-activated protein kinase 3	Homo sapiens	81-87
34025416-10	2021	By recognizing the five compounds related to the ESR1 and IGF1, which are Quercetin, kaempferol, Luteolin, Apigenin, and Emodin.	Emodin	121-127	estrogen receptor 1	Homo sapiens	49-53
34041746-8	2021	Emodin also inhibits activation of several canonical (SMAD2/3) and noncanonical (Erk1/2) TGF-beta signaling pathways, while activating the p38 pathway.	Emodin	0-6	transforming growth factor alpha	Homo sapiens	89-97
34041746-8	2021	Emodin also inhibits activation of several canonical (SMAD2/3) and noncanonical (Erk1/2) TGF-beta signaling pathways, while activating the p38 pathway.	Emodin	0-6	mitogen-activated protein kinase 1	Homo sapiens	139-142
34041746-9	2021	These results suggest that emodin may provide an effective therapeutic agent for fibrosis that functions via specific TGF-beta signaling pathways.	Emodin	27-33	transforming growth factor alpha	Homo sapiens	118-126
34040579-15	2021	Also, emodin significantly increased markers of beige adipocytes, e.g. Cd137, Tmem26 and Tbx1 mRNA in scWAT, and UCP1, CD36, FATP4, PPARalpha and prohibitin protein expression in scWAT and BAT.	Emodin	6-12	tumor necrosis factor receptor superfamily, member 9	Mus musculus	71-76
34040579-15	2021	Also, emodin significantly increased markers of beige adipocytes, e.g. Cd137, Tmem26 and Tbx1 mRNA in scWAT, and UCP1, CD36, FATP4, PPARalpha and prohibitin protein expression in scWAT and BAT.	Emodin	6-12	transmembrane protein 26	Mus musculus	78-84
34040579-15	2021	Also, emodin significantly increased markers of beige adipocytes, e.g. Cd137, Tmem26 and Tbx1 mRNA in scWAT, and UCP1, CD36, FATP4, PPARalpha and prohibitin protein expression in scWAT and BAT.	Emodin	6-12	T-box 1	Mus musculus	89-93
34040579-15	2021	Also, emodin significantly increased markers of beige adipocytes, e.g. Cd137, Tmem26 and Tbx1 mRNA in scWAT, and UCP1, CD36, FATP4, PPARalpha and prohibitin protein expression in scWAT and BAT.	Emodin	6-12	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	113-117
34040579-15	2021	Also, emodin significantly increased markers of beige adipocytes, e.g. Cd137, Tmem26 and Tbx1 mRNA in scWAT, and UCP1, CD36, FATP4, PPARalpha and prohibitin protein expression in scWAT and BAT.	Emodin	6-12	prohibitin	Mus musculus	146-156
34001704-11	2021	Further investigation indicated that reinforcement effect of emodin and DDP may be associated with inhibition of NF-kappaB pathway and drug efflux-related proteins such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and Glutathione S-transferase (GST).	Emodin	61-67	nuclear factor kappa B subunit 1	Homo sapiens	113-122
34001704-11	2021	Further investigation indicated that reinforcement effect of emodin and DDP may be associated with inhibition of NF-kappaB pathway and drug efflux-related proteins such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and Glutathione S-transferase (GST).	Emodin	61-67	ATP binding cassette subfamily B member 1	Homo sapiens	172-186
34001704-11	2021	Further investigation indicated that reinforcement effect of emodin and DDP may be associated with inhibition of NF-kappaB pathway and drug efflux-related proteins such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and Glutathione S-transferase (GST).	Emodin	61-67	ATP binding cassette subfamily B member 1	Homo sapiens	188-192
34001704-11	2021	Further investigation indicated that reinforcement effect of emodin and DDP may be associated with inhibition of NF-kappaB pathway and drug efflux-related proteins such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and Glutathione S-transferase (GST).	Emodin	61-67	ATP binding cassette subfamily C member 3	Homo sapiens	195-234
34001704-11	2021	Further investigation indicated that reinforcement effect of emodin and DDP may be associated with inhibition of NF-kappaB pathway and drug efflux-related proteins such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and Glutathione S-transferase (GST).	Emodin	61-67	ATP binding cassette subfamily C member 3	Homo sapiens	236-239
34001704-11	2021	Further investigation indicated that reinforcement effect of emodin and DDP may be associated with inhibition of NF-kappaB pathway and drug efflux-related proteins such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and Glutathione S-transferase (GST).	Emodin	61-67	glutathione S-transferase kappa 1	Homo sapiens	245-270
34001704-11	2021	Further investigation indicated that reinforcement effect of emodin and DDP may be associated with inhibition of NF-kappaB pathway and drug efflux-related proteins such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and Glutathione S-transferase (GST).	Emodin	61-67	glutathione S-transferase kappa 1	Homo sapiens	272-275
34001704-14	2021	CONCLUSIONS: Emodin reverses the cisplatin resistance of tumor cells by down-regulating expression of P-gp, MRP and GST, increasing the intracellular accumulation in A549/DDP cells, and the effect may be associated with the NF-kappaB pathways.	Emodin	13-19	ATP binding cassette subfamily B member 1	Homo sapiens	102-106
34001704-14	2021	CONCLUSIONS: Emodin reverses the cisplatin resistance of tumor cells by down-regulating expression of P-gp, MRP and GST, increasing the intracellular accumulation in A549/DDP cells, and the effect may be associated with the NF-kappaB pathways.	Emodin	13-19	ATP binding cassette subfamily C member 3	Homo sapiens	108-111
34001704-14	2021	CONCLUSIONS: Emodin reverses the cisplatin resistance of tumor cells by down-regulating expression of P-gp, MRP and GST, increasing the intracellular accumulation in A549/DDP cells, and the effect may be associated with the NF-kappaB pathways.	Emodin	13-19	glutathione S-transferase kappa 1	Homo sapiens	116-119
34001704-14	2021	CONCLUSIONS: Emodin reverses the cisplatin resistance of tumor cells by down-regulating expression of P-gp, MRP and GST, increasing the intracellular accumulation in A549/DDP cells, and the effect may be associated with the NF-kappaB pathways.	Emodin	13-19	nuclear factor kappa B subunit 1	Homo sapiens	224-233
34025416-10	2021	By recognizing the five compounds related to the ESR1 and IGF1, which are Quercetin, kaempferol, Luteolin, Apigenin, and Emodin.	Emodin	121-127	insulin like growth factor 1	Homo sapiens	58-62
33967799-0	2021	Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1beta/CXCL1 Signaling.	Emodin	0-6	cold inducible RNA binding protein	Rattus norvegicus	91-125
32840732-11	2021	The medium-dose (25 mu ml/L) emodin decreased the expressions of NF-kappa B, P62 and p-mTOR (P<0.01) and increased I kappa B alpha expression, LC3B II/I ratio as well as LC3B fluorescence intensity (P<0.05 or P<0.01).	Emodin	29-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	65-75
32840732-11	2021	The medium-dose (25 mu ml/L) emodin decreased the expressions of NF-kappa B, P62 and p-mTOR (P<0.01) and increased I kappa B alpha expression, LC3B II/I ratio as well as LC3B fluorescence intensity (P<0.05 or P<0.01).	Emodin	29-35	nucleoporin 62	Mus musculus	77-80
32840732-11	2021	The medium-dose (25 mu ml/L) emodin decreased the expressions of NF-kappa B, P62 and p-mTOR (P<0.01) and increased I kappa B alpha expression, LC3B II/I ratio as well as LC3B fluorescence intensity (P<0.05 or P<0.01).	Emodin	29-35	mechanistic target of rapamycin kinase	Mus musculus	87-91
32840732-11	2021	The medium-dose (25 mu ml/L) emodin decreased the expressions of NF-kappa B, P62 and p-mTOR (P<0.01) and increased I kappa B alpha expression, LC3B II/I ratio as well as LC3B fluorescence intensity (P<0.05 or P<0.01).	Emodin	29-35	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	115-130
32840732-11	2021	The medium-dose (25 mu ml/L) emodin decreased the expressions of NF-kappa B, P62 and p-mTOR (P<0.01) and increased I kappa B alpha expression, LC3B II/I ratio as well as LC3B fluorescence intensity (P<0.05 or P<0.01).	Emodin	29-35	liver cell immortalization	Mus musculus	143-152
32840732-11	2021	The medium-dose (25 mu ml/L) emodin decreased the expressions of NF-kappa B, P62 and p-mTOR (P<0.01) and increased I kappa B alpha expression, LC3B II/I ratio as well as LC3B fluorescence intensity (P<0.05 or P<0.01).	Emodin	29-35	microtubule-associated protein 1 light chain 3 beta	Mus musculus	143-147
32840732-12	2021	Meanwhile, the enhanced autophagic effects of emodin, such as the increment of LC3B II/ratio and the decrement of P62 expression, were suppressed by autophagy inhibitor 3-MA.	Emodin	46-52	microtubule-associated protein 1 light chain 3 beta	Mus musculus	79-83
32840732-12	2021	Meanwhile, the enhanced autophagic effects of emodin, such as the increment of LC3B II/ratio and the decrement of P62 expression, were suppressed by autophagy inhibitor 3-MA.	Emodin	46-52	nucleoporin 62	Mus musculus	114-117
33967799-9	2021	Results: Emodin treatment significantly reduced inflammation and tissue damages in the pancreatic and lung tissues in rats with SAP-ALI, accompanied by decreasing serum amylase, CIRP and IL-1beta levels and improving lung function.	Emodin	9-15	cold inducible RNA binding protein	Rattus norvegicus	178-182
33967799-9	2021	Results: Emodin treatment significantly reduced inflammation and tissue damages in the pancreatic and lung tissues in rats with SAP-ALI, accompanied by decreasing serum amylase, CIRP and IL-1beta levels and improving lung function.	Emodin	9-15	interleukin 1 alpha	Rattus norvegicus	187-195
33967799-10	2021	Furthermore, emodin significantly mitigated the SAP-up-regulated CIRP expression in the pancreatic islets and lung tissues, and attenuated the SAP-activated NF-kappaB signaling, NLRP3 inflammasome formation and CXCL1 expression in lung resident macrophages as well as neutrophil infiltration in the lungs of rats.	Emodin	13-19	cold inducible RNA binding protein	Rattus norvegicus	65-69
33967799-10	2021	Furthermore, emodin significantly mitigated the SAP-up-regulated CIRP expression in the pancreatic islets and lung tissues, and attenuated the SAP-activated NF-kappaB signaling, NLRP3 inflammasome formation and CXCL1 expression in lung resident macrophages as well as neutrophil infiltration in the lungs of rats.	Emodin	13-19	NLR family, pyrin domain containing 3	Rattus norvegicus	178-183
33967799-10	2021	Furthermore, emodin significantly mitigated the SAP-up-regulated CIRP expression in the pancreatic islets and lung tissues, and attenuated the SAP-activated NF-kappaB signaling, NLRP3 inflammasome formation and CXCL1 expression in lung resident macrophages as well as neutrophil infiltration in the lungs of rats.	Emodin	13-19	C-X-C motif chemokine ligand 1	Rattus norvegicus	211-216
33967799-11	2021	In addition, treatment with CIRP significantly activated the NF-kappaB signaling and NLRP3 inflammasome formation and induced IL-1beta and CXCL1 expression and pyroptosis in NR8383 cells, which were abrogated by TAK242 and significantly mitigated by C23 or emodin.	Emodin	257-263	cold inducible RNA binding protein	Rattus norvegicus	28-32
33967799-13	2021	Conclusion: Emodin may inhibit the CIRP-activated NLRP3/IL-1beta/CXCL1signaling to decrease neutrophil infiltration and ameliorate the SAP-ALI in rats.	Emodin	12-18	cold inducible RNA binding protein	Rattus norvegicus	35-39
33967799-0	2021	Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1beta/CXCL1 Signaling.	Emodin	0-6	cold inducible RNA binding protein	Rattus norvegicus	127-131
33967799-13	2021	Conclusion: Emodin may inhibit the CIRP-activated NLRP3/IL-1beta/CXCL1signaling to decrease neutrophil infiltration and ameliorate the SAP-ALI in rats.	Emodin	12-18	NLR family, pyrin domain containing 3	Rattus norvegicus	50-55
33967799-13	2021	Conclusion: Emodin may inhibit the CIRP-activated NLRP3/IL-1beta/CXCL1signaling to decrease neutrophil infiltration and ameliorate the SAP-ALI in rats.	Emodin	12-18	interleukin 1 alpha	Rattus norvegicus	56-64
33967799-13	2021	Conclusion: Emodin may inhibit the CIRP-activated NLRP3/IL-1beta/CXCL1signaling to decrease neutrophil infiltration and ameliorate the SAP-ALI in rats.	Emodin	12-18	C-X-C motif chemokine ligand 1	Rattus norvegicus	65-70
33967799-0	2021	Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1beta/CXCL1 Signaling.	Emodin	0-6	NLR family, pyrin domain containing 3	Rattus norvegicus	160-165
33967799-0	2021	Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1beta/CXCL1 Signaling.	Emodin	0-6	interleukin 1 alpha	Rattus norvegicus	166-174
33968299-0	2021	Emodin-Induced Oxidative Inhibition of Mitochondrial Function Assists BiP/IRE1alpha/CHOP Signaling-Mediated ER-Related Apoptosis.	Emodin	0-6	heat shock protein family A (Hsp70) member 5	Homo sapiens	70-73
33967799-0	2021	Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1beta/CXCL1 Signaling.	Emodin	0-6	C-X-C motif chemokine ligand 1	Rattus norvegicus	175-180
33968299-0	2021	Emodin-Induced Oxidative Inhibition of Mitochondrial Function Assists BiP/IRE1alpha/CHOP Signaling-Mediated ER-Related Apoptosis.	Emodin	0-6	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	74-83
33968299-3	2021	Hence, the present study firstly explored the possible role of oxidative stress-mediated mitochondrial dysfunction and ER stress in emodin-cause apoptosis of L02 cells, aiming to elaborate possible toxic mechanisms involved in emodin-induced hepatotoxicity.	Emodin	227-233	epiregulin	Homo sapiens	119-121
33508903-6	2021	From molecular docking studies, the relative binding energies of the emodin and aloe-emodin derivatives to human serum albumin ranged from -7.30 and -10.62 kcal/mol.	Emodin	69-75	albumin	Homo sapiens	119-126
33968299-4	2021	Our results showed that emodin-induced ROS activated ER stress and the UPR via the BiP/IRE1alpha/CHOP signaling pathway, followed by ER Ca2+ release and cytoplasmic Ca2+ overloading.	Emodin	24-30	epiregulin	Homo sapiens	53-55
33968299-4	2021	Our results showed that emodin-induced ROS activated ER stress and the UPR via the BiP/IRE1alpha/CHOP signaling pathway, followed by ER Ca2+ release and cytoplasmic Ca2+ overloading.	Emodin	24-30	heat shock protein family A (Hsp70) member 5	Homo sapiens	83-86
33968299-4	2021	Our results showed that emodin-induced ROS activated ER stress and the UPR via the BiP/IRE1alpha/CHOP signaling pathway, followed by ER Ca2+ release and cytoplasmic Ca2+ overloading.	Emodin	24-30	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	87-96
33968299-4	2021	Our results showed that emodin-induced ROS activated ER stress and the UPR via the BiP/IRE1alpha/CHOP signaling pathway, followed by ER Ca2+ release and cytoplasmic Ca2+ overloading.	Emodin	24-30	DNA damage inducible transcript 3	Homo sapiens	97-101
33968299-9	2021	Thus, all the results indicated that emodin-induced excessive ROS generation and redox imbalance promoted apoptosis, which was mainly associated with BiP/IRE1alpha/CHOP signaling-mediated ER stress and would be enhanced by oxidative stress-mediated mitochondrial dysfunction.	Emodin	37-43	heat shock protein family A (Hsp70) member 5	Homo sapiens	150-153
33968299-9	2021	Thus, all the results indicated that emodin-induced excessive ROS generation and redox imbalance promoted apoptosis, which was mainly associated with BiP/IRE1alpha/CHOP signaling-mediated ER stress and would be enhanced by oxidative stress-mediated mitochondrial dysfunction.	Emodin	37-43	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	154-163
33968299-9	2021	Thus, all the results indicated that emodin-induced excessive ROS generation and redox imbalance promoted apoptosis, which was mainly associated with BiP/IRE1alpha/CHOP signaling-mediated ER stress and would be enhanced by oxidative stress-mediated mitochondrial dysfunction.	Emodin	37-43	DNA damage inducible transcript 3	Homo sapiens	164-168
33968299-0	2021	Emodin-Induced Oxidative Inhibition of Mitochondrial Function Assists BiP/IRE1alpha/CHOP Signaling-Mediated ER-Related Apoptosis.	Emodin	0-6	DNA damage inducible transcript 3	Homo sapiens	84-88
33968299-0	2021	Emodin-Induced Oxidative Inhibition of Mitochondrial Function Assists BiP/IRE1alpha/CHOP Signaling-Mediated ER-Related Apoptosis.	Emodin	0-6	epiregulin	Homo sapiens	108-110
33968299-3	2021	Hence, the present study firstly explored the possible role of oxidative stress-mediated mitochondrial dysfunction and ER stress in emodin-cause apoptosis of L02 cells, aiming to elaborate possible toxic mechanisms involved in emodin-induced hepatotoxicity.	Emodin	132-138	epiregulin	Homo sapiens	119-121
33274693-0	2021	The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection.	Emodin	30-36	toll like receptor 3	Homo sapiens	40-44
32930996-9	2021	Inhibiting the adenosine monophosphate-activated protein kinase (AMPK) or silencing of the nuclear factor erythroid 2-related factor 2 (Nrf2), transcription factor abolished the EM-induced protection.	Emodin	178-180	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	15-63
32930996-9	2021	Inhibiting the adenosine monophosphate-activated protein kinase (AMPK) or silencing of the nuclear factor erythroid 2-related factor 2 (Nrf2), transcription factor abolished the EM-induced protection.	Emodin	178-180	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	65-69
33731543-5	2021	CCK-8,colony formation test and Annexin V-FITC / PI staining tests confirmed that emodin possessed anti-proliferative and pro-apoptotic activities in B16F10 and A375 cells.	Emodin	82-88	annexin A5	Mus musculus	32-41
32930996-9	2021	Inhibiting the adenosine monophosphate-activated protein kinase (AMPK) or silencing of the nuclear factor erythroid 2-related factor 2 (Nrf2), transcription factor abolished the EM-induced protection.	Emodin	178-180	NFE2 like bZIP transcription factor 2	Homo sapiens	91-134
32930996-9	2021	Inhibiting the adenosine monophosphate-activated protein kinase (AMPK) or silencing of the nuclear factor erythroid 2-related factor 2 (Nrf2), transcription factor abolished the EM-induced protection.	Emodin	178-180	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
32930996-10	2021	Inhibition of heme oxygenase-1 (HO-1) also blocked the EM-induced mitochondrial protection.	Emodin	55-57	heme oxygenase 1	Homo sapiens	14-30
32930996-10	2021	Inhibition of heme oxygenase-1 (HO-1) also blocked the EM-induced mitochondrial protection.	Emodin	55-57	heme oxygenase 1	Homo sapiens	32-36
33731543-8	2021	BML-284, as an agonist of Wnt/beta-catenin signaling pathway, reversed the effects of emodin on cell growth, migration and invasion in B16F10 cells.	Emodin	86-92	catenin (cadherin associated protein), beta 1	Mus musculus	30-42
33731248-4	2021	In our study, we found that emodin inhibited the invasion and migration abilities of RKO cells and decreased the expression of matrix metalloproteinase-7 (MMP-7), MMP-9, and vascular endothelial growth factor (VEGF) in a dose-dependent manner.	Emodin	28-34	matrix metallopeptidase 7	Homo sapiens	127-153
33731248-4	2021	In our study, we found that emodin inhibited the invasion and migration abilities of RKO cells and decreased the expression of matrix metalloproteinase-7 (MMP-7), MMP-9, and vascular endothelial growth factor (VEGF) in a dose-dependent manner.	Emodin	28-34	matrix metallopeptidase 7	Homo sapiens	155-160
33731248-4	2021	In our study, we found that emodin inhibited the invasion and migration abilities of RKO cells and decreased the expression of matrix metalloproteinase-7 (MMP-7), MMP-9, and vascular endothelial growth factor (VEGF) in a dose-dependent manner.	Emodin	28-34	vascular endothelial growth factor A	Homo sapiens	174-208
33731248-4	2021	In our study, we found that emodin inhibited the invasion and migration abilities of RKO cells and decreased the expression of matrix metalloproteinase-7 (MMP-7), MMP-9, and vascular endothelial growth factor (VEGF) in a dose-dependent manner.	Emodin	28-34	matrix metallopeptidase 9	Homo sapiens	163-168
33731248-4	2021	In our study, we found that emodin inhibited the invasion and migration abilities of RKO cells and decreased the expression of matrix metalloproteinase-7 (MMP-7), MMP-9, and vascular endothelial growth factor (VEGF) in a dose-dependent manner.	Emodin	28-34	vascular endothelial growth factor A	Homo sapiens	210-214
33421527-7	2021	Tissue expression of MMP-3, MMP-13, ADAMTS-4 and iNOS were significantly (p < 0.05) decreased in chondrocytes and cartilage treated with different doses of emodin, and the content of COL2A1 was reversed.	Emodin	156-162	matrix metallopeptidase 3	Rattus norvegicus	21-26
33731248-5	2021	Further research suggested that emodin inhibited EMT by increasing the mRNA level of E-cadherin and decreasing the expression of N-cadherin, Snail, and -catenin.	Emodin	32-38	cadherin 1	Homo sapiens	85-95
33731248-5	2021	Further research suggested that emodin inhibited EMT by increasing the mRNA level of E-cadherin and decreasing the expression of N-cadherin, Snail, and -catenin.	Emodin	32-38	cadherin 2	Homo sapiens	129-139
33731248-5	2021	Further research suggested that emodin inhibited EMT by increasing the mRNA level of E-cadherin and decreasing the expression of N-cadherin, Snail, and -catenin.	Emodin	32-38	snail family transcriptional repressor 1	Homo sapiens	141-160
33731248-6	2021	Emodin also significantly inhibited the activation of the Wnt/-catenin signaling pathway by downregulating the expression of related downstream target genes, including TCF4, cyclin D1, and c-Myc.	Emodin	0-6	transcription factor 4	Homo sapiens	168-172
33731248-6	2021	Emodin also significantly inhibited the activation of the Wnt/-catenin signaling pathway by downregulating the expression of related downstream target genes, including TCF4, cyclin D1, and c-Myc.	Emodin	0-6	cyclin D1	Homo sapiens	174-183
33421527-7	2021	Tissue expression of MMP-3, MMP-13, ADAMTS-4 and iNOS were significantly (p < 0.05) decreased in chondrocytes and cartilage treated with different doses of emodin, and the content of COL2A1 was reversed.	Emodin	156-162	matrix metallopeptidase 13	Rattus norvegicus	28-34
33421527-7	2021	Tissue expression of MMP-3, MMP-13, ADAMTS-4 and iNOS were significantly (p < 0.05) decreased in chondrocytes and cartilage treated with different doses of emodin, and the content of COL2A1 was reversed.	Emodin	156-162	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	36-44
33421527-7	2021	Tissue expression of MMP-3, MMP-13, ADAMTS-4 and iNOS were significantly (p < 0.05) decreased in chondrocytes and cartilage treated with different doses of emodin, and the content of COL2A1 was reversed.	Emodin	156-162	nitric oxide synthase 2	Rattus norvegicus	49-53
33421527-7	2021	Tissue expression of MMP-3, MMP-13, ADAMTS-4 and iNOS were significantly (p < 0.05) decreased in chondrocytes and cartilage treated with different doses of emodin, and the content of COL2A1 was reversed.	Emodin	156-162	collagen type II alpha 1 chain	Rattus norvegicus	183-189
33421527-8	2021	Emodin also significantly decreased the blood levels of COX-2 and PGE2.	Emodin	0-6	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	56-61
33645356-2	2022	Emodin being a phytoestrogen shows anti-carcinogenic properties especially in estrogen receptor positive (ER+) breast cancers.	Emodin	0-6	estrogen receptor 1	Homo sapiens	78-95
33219897-0	2021	Mitochondrial Protection and Anti-inflammatory Effects Induced by Emodin in the Human Neuroblastoma SH-SY5Y Cells Exposed to Hydrogen Peroxide: Involvement of the AMPK/Nrf2 Signaling Pathway.	Emodin	66-72	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	163-167
33219897-0	2021	Mitochondrial Protection and Anti-inflammatory Effects Induced by Emodin in the Human Neuroblastoma SH-SY5Y Cells Exposed to Hydrogen Peroxide: Involvement of the AMPK/Nrf2 Signaling Pathway.	Emodin	66-72	NFE2 like bZIP transcription factor 2	Homo sapiens	168-172
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Emodin	30-32	interleukin 1 beta	Homo sapiens	131-148
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Emodin	30-32	interleukin 1 alpha	Homo sapiens	150-158
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Emodin	30-32	tumor necrosis factor	Homo sapiens	164-191
33219897-6	2021	An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells.	Emodin	30-32	tumor necrosis factor	Homo sapiens	193-202
33219897-7	2021	Inhibition of the adenosine monophosphate-activated protein kinase (AMPK) or silencing of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) abolished the protection induced by EM in the H2O2-treated cells.	Emodin	202-204	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	18-66
33219897-7	2021	Inhibition of the adenosine monophosphate-activated protein kinase (AMPK) or silencing of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) abolished the protection induced by EM in the H2O2-treated cells.	Emodin	202-204	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	68-72
33219897-7	2021	Inhibition of the adenosine monophosphate-activated protein kinase (AMPK) or silencing of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) abolished the protection induced by EM in the H2O2-treated cells.	Emodin	202-204	NFE2 like bZIP transcription factor 2	Homo sapiens	115-158
33219897-7	2021	Inhibition of the adenosine monophosphate-activated protein kinase (AMPK) or silencing of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) abolished the protection induced by EM in the H2O2-treated cells.	Emodin	202-204	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
33219897-8	2021	Therefore, EM prevented the H2O2-induced mitochondrial dysfunction and pro-inflammatory state in the SH-SY5Y cells by an AMPK/Nrf2-dependent manner.	Emodin	11-13	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	121-125
33219897-8	2021	Therefore, EM prevented the H2O2-induced mitochondrial dysfunction and pro-inflammatory state in the SH-SY5Y cells by an AMPK/Nrf2-dependent manner.	Emodin	11-13	NFE2 like bZIP transcription factor 2	Homo sapiens	126-130
33645356-2	2022	Emodin being a phytoestrogen shows anti-carcinogenic properties especially in estrogen receptor positive (ER+) breast cancers.	Emodin	0-6	epiregulin	Homo sapiens	106-108
33645356-3	2022	The aim of this study is to identify the molecular mechanism and related biological pathways in both (ER+) MCF-7 and (ER-) MDA-MB-231 breast cancer cell lines upon Emodin treatment via microarray analysis in order to find out therapeutic biomarkers.	Emodin	164-170	epiregulin	Homo sapiens	102-104
33645356-3	2022	The aim of this study is to identify the molecular mechanism and related biological pathways in both (ER+) MCF-7 and (ER-) MDA-MB-231 breast cancer cell lines upon Emodin treatment via microarray analysis in order to find out therapeutic biomarkers.	Emodin	164-170	epiregulin	Homo sapiens	118-120
33645356-10	2022	As a result, novel gene regulations reported in this study in response to Emodin will give more information about its metabolism and antiproliferative effect, especially in ER + cells.	Emodin	74-80	epiregulin	Homo sapiens	173-175
33647480-9	2021	Emodin treatment activated the Nuclear factorery throid 2-related factor 2/Kelch-like ECH-associated protein 1-antioxidatant response element (Nrf2/Keap1-ARE) pathway and upregulated the expression of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) in the hepatopancreas after CyHV-3 infection.	Emodin	0-6	NFE2 like bZIP transcription factor 2	Homo sapiens	31-74
33647480-9	2021	Emodin treatment activated the Nuclear factorery throid 2-related factor 2/Kelch-like ECH-associated protein 1-antioxidatant response element (Nrf2/Keap1-ARE) pathway and upregulated the expression of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) in the hepatopancreas after CyHV-3 infection.	Emodin	0-6	kelch like ECH associated protein 1	Homo sapiens	75-110
33647480-9	2021	Emodin treatment activated the Nuclear factorery throid 2-related factor 2/Kelch-like ECH-associated protein 1-antioxidatant response element (Nrf2/Keap1-ARE) pathway and upregulated the expression of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) in the hepatopancreas after CyHV-3 infection.	Emodin	0-6	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
33647480-9	2021	Emodin treatment activated the Nuclear factorery throid 2-related factor 2/Kelch-like ECH-associated protein 1-antioxidatant response element (Nrf2/Keap1-ARE) pathway and upregulated the expression of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) in the hepatopancreas after CyHV-3 infection.	Emodin	0-6	kelch like ECH associated protein 1	Homo sapiens	148-153
33647480-9	2021	Emodin treatment activated the Nuclear factorery throid 2-related factor 2/Kelch-like ECH-associated protein 1-antioxidatant response element (Nrf2/Keap1-ARE) pathway and upregulated the expression of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) in the hepatopancreas after CyHV-3 infection.	Emodin	0-6	heme oxygenase 1	Homo sapiens	201-217
33647480-9	2021	Emodin treatment activated the Nuclear factorery throid 2-related factor 2/Kelch-like ECH-associated protein 1-antioxidatant response element (Nrf2/Keap1-ARE) pathway and upregulated the expression of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) in the hepatopancreas after CyHV-3 infection.	Emodin	0-6	heme oxygenase 1	Homo sapiens	219-223
33647480-9	2021	Emodin treatment activated the Nuclear factorery throid 2-related factor 2/Kelch-like ECH-associated protein 1-antioxidatant response element (Nrf2/Keap1-ARE) pathway and upregulated the expression of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) in the hepatopancreas after CyHV-3 infection.	Emodin	0-6	superoxide dismutase 1	Homo sapiens	248-251
33647480-9	2021	Emodin treatment activated the Nuclear factorery throid 2-related factor 2/Kelch-like ECH-associated protein 1-antioxidatant response element (Nrf2/Keap1-ARE) pathway and upregulated the expression of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) in the hepatopancreas after CyHV-3 infection.	Emodin	0-6	catalase	Homo sapiens	258-266
33647480-9	2021	Emodin treatment activated the Nuclear factorery throid 2-related factor 2/Kelch-like ECH-associated protein 1-antioxidatant response element (Nrf2/Keap1-ARE) pathway and upregulated the expression of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) in the hepatopancreas after CyHV-3 infection.	Emodin	0-6	catalase	Homo sapiens	268-271
33647480-12	2021	Emodin improves antioxidant function, relieves oxidative stress and inflammation cytokines via Nrf2/Keap1-ARE and NF-kappaB pathways, and protects against the adverse effects induced by CyHV-3.	Emodin	0-6	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
33647480-12	2021	Emodin improves antioxidant function, relieves oxidative stress and inflammation cytokines via Nrf2/Keap1-ARE and NF-kappaB pathways, and protects against the adverse effects induced by CyHV-3.	Emodin	0-6	kelch like ECH associated protein 1	Homo sapiens	100-105
33647480-12	2021	Emodin improves antioxidant function, relieves oxidative stress and inflammation cytokines via Nrf2/Keap1-ARE and NF-kappaB pathways, and protects against the adverse effects induced by CyHV-3.	Emodin	0-6	nuclear factor kappa B subunit 1	Homo sapiens	114-123
33532038-6	2021	In this study, we found that emodin effectively killed renal cancer cells without significant toxicity to noncancerous cell HK-2.	Emodin	29-35	hexokinase 2	Homo sapiens	124-128
33634018-0	2020	Emodin Interferes With AKT1-Mediated DNA Damage and Decreases Resistance of Breast Cancer Cells to Doxorubicin.	Emodin	0-6	AKT serine/threonine kinase 1	Homo sapiens	23-27
33634018-10	2020	Besides, we confirmed that Emodin confers sensitization of BC to doxorubicin through AKT1-mediated DNA.	Emodin	27-33	AKT serine/threonine kinase 1	Homo sapiens	85-89
33438315-5	2021	Results showed both emodin and DEX were therapeutic for SAP-ALI and that mRNA and lncRNA levels differed between untreated and treated SAP-ALI rats.	Emodin	20-26	amyloid P component, serum	Rattus norvegicus	56-59
33438315-12	2021	Also, emodin had different effects compared with DEX on co-expression network of lncRNAs Rn60_7_1164.1 and AABR07062477.2 for the blue lncRNA module and Nrp1 for the green mRNA module.	Emodin	6-12	neuropilin 1	Rattus norvegicus	153-157
33542691-0	2020	Emodin Inhibits the Proliferation of MCF-7 Human Breast Cancer Cells Through Activation of Aryl Hydrocarbon Receptor (AhR).	Emodin	0-6	aryl hydrocarbon receptor	Homo sapiens	91-116
33542691-0	2020	Emodin Inhibits the Proliferation of MCF-7 Human Breast Cancer Cells Through Activation of Aryl Hydrocarbon Receptor (AhR).	Emodin	0-6	aryl hydrocarbon receptor	Homo sapiens	118-121
33542691-9	2020	Furthermore, virtual screening studies indicated that emodin was a potent aryl hydrocarbon receptor (AhR) agonist in chemotherapy for breast cancer.	Emodin	54-60	aryl hydrocarbon receptor	Homo sapiens	74-99
33542691-9	2020	Furthermore, virtual screening studies indicated that emodin was a potent aryl hydrocarbon receptor (AhR) agonist in chemotherapy for breast cancer.	Emodin	54-60	aryl hydrocarbon receptor	Homo sapiens	101-104
33542691-10	2020	Finally, when MCF-7 cells were treated with emodin (100 mumol/L) for 24 h, the AhR and cytochrome P450 1A1 (CYP1A1) protein expression levels were significantly upregulated compared with the control group.	Emodin	44-50	aryl hydrocarbon receptor	Homo sapiens	79-82
33542691-10	2020	Finally, when MCF-7 cells were treated with emodin (100 mumol/L) for 24 h, the AhR and cytochrome P450 1A1 (CYP1A1) protein expression levels were significantly upregulated compared with the control group.	Emodin	44-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-106
33542691-10	2020	Finally, when MCF-7 cells were treated with emodin (100 mumol/L) for 24 h, the AhR and cytochrome P450 1A1 (CYP1A1) protein expression levels were significantly upregulated compared with the control group.	Emodin	44-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	108-114
33542691-11	2020	Our study indicated that emodin exhibited promising antitumor activity in MCF-7 cells, likely through activation of the AhR-CYP1A1 signaling pathway.	Emodin	25-31	aryl hydrocarbon receptor	Homo sapiens	120-123
33542691-11	2020	Our study indicated that emodin exhibited promising antitumor activity in MCF-7 cells, likely through activation of the AhR-CYP1A1 signaling pathway.	Emodin	25-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	124-130
33352442-4	2021	We also demonstrated that emodin effectively inhibited the phosphorylation of Smad3 and NF-kappaB and reduced the levels of inflammatory factors in the lung tissue of mice treated with silica particles.	Emodin	26-32	SMAD family member 3	Mus musculus	78-83
33352442-4	2021	We also demonstrated that emodin effectively inhibited the phosphorylation of Smad3 and NF-kappaB and reduced the levels of inflammatory factors in the lung tissue of mice treated with silica particles.	Emodin	26-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97
33352442-5	2021	In addition, we found that emodin inhibited apoptosis and demonstrated an anti-fibrotic effect by down-regulating the pro-apoptotic protein Bax and up-regulating the anti-apoptotic protein Bcl-2.	Emodin	27-33	BCL2-associated X protein	Mus musculus	140-143
33352442-5	2021	In addition, we found that emodin inhibited apoptosis and demonstrated an anti-fibrotic effect by down-regulating the pro-apoptotic protein Bax and up-regulating the anti-apoptotic protein Bcl-2.	Emodin	27-33	B cell leukemia/lymphoma 2	Mus musculus	189-194
33300068-0	2021	Neuroprotective effect of emodin against Alzheimer"s disease via Nrf2 signaling in U251 cells and APP/PS1 mice.	Emodin	26-32	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
33300068-0	2021	Neuroprotective effect of emodin against Alzheimer"s disease via Nrf2 signaling in U251 cells and APP/PS1 mice.	Emodin	26-32	presenilin 1	Homo sapiens	102-105
33300068-2	2021	In the present study, potential neuroprotective effects associated with the antioxidant activity of emodin were assessed in U251 cells that were subjected to beta-amyloid peptide (Abeta)-induced apoptosis and in amyloid precursor protein (APP)/presenilin-1 (PS1) double-transgenic mice.	Emodin	100-106	amyloid beta precursor protein	Homo sapiens	158-178
33300068-2	2021	In the present study, potential neuroprotective effects associated with the antioxidant activity of emodin were assessed in U251 cells that were subjected to beta-amyloid peptide (Abeta)-induced apoptosis and in amyloid precursor protein (APP)/presenilin-1 (PS1) double-transgenic mice.	Emodin	100-106	amyloid beta precursor protein	Homo sapiens	180-185
33300068-2	2021	In the present study, potential neuroprotective effects associated with the antioxidant activity of emodin were assessed in U251 cells that were subjected to beta-amyloid peptide (Abeta)-induced apoptosis and in amyloid precursor protein (APP)/presenilin-1 (PS1) double-transgenic mice.	Emodin	100-106	amyloid beta precursor protein	Homo sapiens	212-237
33300068-2	2021	In the present study, potential neuroprotective effects associated with the antioxidant activity of emodin were assessed in U251 cells that were subjected to beta-amyloid peptide (Abeta)-induced apoptosis and in amyloid precursor protein (APP)/presenilin-1 (PS1) double-transgenic mice.	Emodin	100-106	presenilin 1	Homo sapiens	244-256
33300068-2	2021	In the present study, potential neuroprotective effects associated with the antioxidant activity of emodin were assessed in U251 cells that were subjected to beta-amyloid peptide (Abeta)-induced apoptosis and in amyloid precursor protein (APP)/presenilin-1 (PS1) double-transgenic mice.	Emodin	100-106	presenilin 1	Homo sapiens	258-261
33300068-6	2021	In apoptotic U251 cells, 3-h emodin pre-treatment prior to 24-h Abeta co-exposure improved cell viability, suppressed lactate dehydrogenase leakage and caspase-3, -8 and -9 activation to inhibit apoptosis.	Emodin	29-35	amyloid beta precursor protein	Homo sapiens	64-69
33300068-6	2021	In apoptotic U251 cells, 3-h emodin pre-treatment prior to 24-h Abeta co-exposure improved cell viability, suppressed lactate dehydrogenase leakage and caspase-3, -8 and -9 activation to inhibit apoptosis.	Emodin	29-35	caspase 3	Homo sapiens	152-172
33300068-7	2021	Compared with those after Abeta exposure alone, emodin ameliorated the dissipation of the mitochondrial membrane potential, inhibited the over-accumulation of reactive oxygen species, enhanced the expression levels of nuclear factor-erythroid-2-related factor 2 (Nrf2), haemeoxygenase-1, superoxide dismutase 1, Bcl-2 and catalase in addition to decreasing the expression levels of Bax.	Emodin	48-54	amyloid beta (A4) precursor protein	Mus musculus	26-31
33300068-7	2021	Compared with those after Abeta exposure alone, emodin ameliorated the dissipation of the mitochondrial membrane potential, inhibited the over-accumulation of reactive oxygen species, enhanced the expression levels of nuclear factor-erythroid-2-related factor 2 (Nrf2), haemeoxygenase-1, superoxide dismutase 1, Bcl-2 and catalase in addition to decreasing the expression levels of Bax.	Emodin	48-54	NFE2 like bZIP transcription factor 2	Homo sapiens	218-261
33300068-7	2021	Compared with those after Abeta exposure alone, emodin ameliorated the dissipation of the mitochondrial membrane potential, inhibited the over-accumulation of reactive oxygen species, enhanced the expression levels of nuclear factor-erythroid-2-related factor 2 (Nrf2), haemeoxygenase-1, superoxide dismutase 1, Bcl-2 and catalase in addition to decreasing the expression levels of Bax.	Emodin	48-54	NFE2 like bZIP transcription factor 2	Homo sapiens	263-267
33300068-7	2021	Compared with those after Abeta exposure alone, emodin ameliorated the dissipation of the mitochondrial membrane potential, inhibited the over-accumulation of reactive oxygen species, enhanced the expression levels of nuclear factor-erythroid-2-related factor 2 (Nrf2), haemeoxygenase-1, superoxide dismutase 1, Bcl-2 and catalase in addition to decreasing the expression levels of Bax.	Emodin	48-54	superoxide dismutase 1	Homo sapiens	288-310
33300068-7	2021	Compared with those after Abeta exposure alone, emodin ameliorated the dissipation of the mitochondrial membrane potential, inhibited the over-accumulation of reactive oxygen species, enhanced the expression levels of nuclear factor-erythroid-2-related factor 2 (Nrf2), haemeoxygenase-1, superoxide dismutase 1, Bcl-2 and catalase in addition to decreasing the expression levels of Bax.	Emodin	48-54	BCL2 apoptosis regulator	Homo sapiens	312-317
33300068-7	2021	Compared with those after Abeta exposure alone, emodin ameliorated the dissipation of the mitochondrial membrane potential, inhibited the over-accumulation of reactive oxygen species, enhanced the expression levels of nuclear factor-erythroid-2-related factor 2 (Nrf2), haemeoxygenase-1, superoxide dismutase 1, Bcl-2 and catalase in addition to decreasing the expression levels of Bax.	Emodin	48-54	catalase	Homo sapiens	322-330
33300068-7	2021	Compared with those after Abeta exposure alone, emodin ameliorated the dissipation of the mitochondrial membrane potential, inhibited the over-accumulation of reactive oxygen species, enhanced the expression levels of nuclear factor-erythroid-2-related factor 2 (Nrf2), haemeoxygenase-1, superoxide dismutase 1, Bcl-2 and catalase in addition to decreasing the expression levels of Bax.	Emodin	48-54	BCL2 associated X, apoptosis regulator	Homo sapiens	382-385
33300068-8	2021	In APP/PS1 mice, an 8-week course of emodin administration improved spatial memory and learning ability and decreased anxiety.	Emodin	37-43	presenilin 1	Mus musculus	7-10
33300068-9	2021	Emodin was also found to regulate key components in the Nrf2 pathway and decreased the deposition of Abeta, phosphorylated-tau and 4-hydroxy-2-nonenal in APP/PS1 mice.	Emodin	0-6	nuclear factor, erythroid derived 2, like 2	Mus musculus	56-60
33300068-9	2021	Emodin was also found to regulate key components in the Nrf2 pathway and decreased the deposition of Abeta, phosphorylated-tau and 4-hydroxy-2-nonenal in APP/PS1 mice.	Emodin	0-6	amyloid beta (A4) precursor protein	Mus musculus	101-106
33300068-9	2021	Emodin was also found to regulate key components in the Nrf2 pathway and decreased the deposition of Abeta, phosphorylated-tau and 4-hydroxy-2-nonenal in APP/PS1 mice.	Emodin	0-6	presenilin 1	Mus musculus	158-161
33532038-7	2021	Flow cytometry assay with Annexin V-FITC and PI demonstrated that emodin induces necroptosis, but not apoptosis, in renal cancer cells.	Emodin	66-72	annexin A5	Homo sapiens	26-35
33532038-10	2021	Further studies demonstrated that emodin induces necroptosis through ROS-mediated activation of JNK signaling pathway and also inhibits glycolysis by downregulation of GLUT1 through ROS-mediated inactivation of the PI3K/AKT signaling pathway.	Emodin	34-40	mitogen-activated protein kinase 8	Homo sapiens	96-99
33532038-10	2021	Further studies demonstrated that emodin induces necroptosis through ROS-mediated activation of JNK signaling pathway and also inhibits glycolysis by downregulation of GLUT1 through ROS-mediated inactivation of the PI3K/AKT signaling pathway.	Emodin	34-40	solute carrier family 2 member 1	Homo sapiens	168-173
33532038-10	2021	Further studies demonstrated that emodin induces necroptosis through ROS-mediated activation of JNK signaling pathway and also inhibits glycolysis by downregulation of GLUT1 through ROS-mediated inactivation of the PI3K/AKT signaling pathway.	Emodin	34-40	AKT serine/threonine kinase 1	Homo sapiens	220-223
33532038-11	2021	Our findings revealed the potential mechanisms by which emodin suppresses renal cancer cell growth and will help develop novel therapeutic approaches for patients with JNK- or PI3K/AKT-dysregulated renal cancer.	Emodin	56-62	mitogen-activated protein kinase 8	Homo sapiens	168-171
33407495-10	2021	The knockdown of either the synthases or the receptors blocked emodin effects on viability while the knockdown of HAS2 block emodin effects but not HAS3.	Emodin	125-131	hyaluronan synthase 2	Homo sapiens	114-118
33489875-5	2020	At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks.	Emodin	26-32	integrin subunit alpha M	Homo sapiens	76-81
33489875-5	2020	At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks.	Emodin	26-32	tumor necrosis factor	Homo sapiens	123-131
33489875-5	2020	At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks.	Emodin	26-32	interleukin 1 alpha	Homo sapiens	133-146
33489875-5	2020	At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks.	Emodin	26-32	interleukin 6	Homo sapiens	148-151
33489875-5	2020	At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks.	Emodin	26-32	C-C motif chemokine ligand 2	Homo sapiens	153-157
33489875-5	2020	At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks.	Emodin	26-32	C-X-C motif chemokine ligand 5	Homo sapiens	159-164
33489875-5	2020	At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks.	Emodin	26-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	201-206
33489875-5	2020	At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks.	Emodin	26-32	nitric oxide synthase 2	Homo sapiens	208-212
33407495-4	2021	We hypothesis that emodin suppresses lung cancer cells through hyaluronan (HA) synthase 2-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway mediated cell cycle regulation.	Emodin	19-25	hyaluronan mediated motility receptor	Homo sapiens	146-151
33407495-11	2021	Emodin increased cells in the G1/G0 phase, and decreased cells in the S and G2/M phase by down-regulating cyclin A and B and up-regulating cyclin C, D, and E. HAS2 knockdown blocked the effects of emodin on the cell cycle.	Emodin	0-6	cyclin A2	Homo sapiens	106-120
33407495-11	2021	Emodin increased cells in the G1/G0 phase, and decreased cells in the S and G2/M phase by down-regulating cyclin A and B and up-regulating cyclin C, D, and E. HAS2 knockdown blocked the effects of emodin on the cell cycle.	Emodin	0-6	cyclin C	Homo sapiens	139-147
33407495-11	2021	Emodin increased cells in the G1/G0 phase, and decreased cells in the S and G2/M phase by down-regulating cyclin A and B and up-regulating cyclin C, D, and E. HAS2 knockdown blocked the effects of emodin on the cell cycle.	Emodin	0-6	hyaluronan synthase 2	Homo sapiens	159-163
33407495-11	2021	Emodin increased cells in the G1/G0 phase, and decreased cells in the S and G2/M phase by down-regulating cyclin A and B and up-regulating cyclin C, D, and E. HAS2 knockdown blocked the effects of emodin on the cell cycle.	Emodin	197-203	hyaluronan synthase 2	Homo sapiens	159-163
33370686-7	2021	Luna C18 column was used under isocratic conditions to separate curcumin, piperine, and emodin with baseline resolution, and with good separation from other sample components, in as little as 4 min.	Emodin	88-94	Bardet-Biedl syndrome 9	Homo sapiens	5-8
33176055-9	2021	Screening for putative substrates revealed binding of phenolic compounds such as L-mimosine and emodin, suggesting a potential application of this new thermophilic P450 in the production of the corresponding hydroxylated products.	Emodin	96-102	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	164-168
33403025-0	2021	A Double-Edged Sword: The Anti-Cancer Effects of Emodin by Inhibiting the Redox-Protective Protein MTH1 and Augmenting ROS in NSCLC.	Emodin	49-55	nudix hydrolase 1	Homo sapiens	99-103
33403025-5	2021	Emodin was identified as a lead compound for MTH1 active site functional inhibition and its action on MTH1 inhibition was validated on non-small cell lung cancer cellular models (NSCLC).	Emodin	0-6	nudix hydrolase 1	Homo sapiens	45-49
33403025-5	2021	Emodin was identified as a lead compound for MTH1 active site functional inhibition and its action on MTH1 inhibition was validated on non-small cell lung cancer cellular models (NSCLC).	Emodin	0-6	nudix hydrolase 1	Homo sapiens	102-106
33403025-6	2021	Results: Our study provides strong evidence that emodin mediated MTH1 inhibition impaired NSCLC cell growth, inducing senescence.	Emodin	49-55	nudix hydrolase 1	Homo sapiens	65-69
33403025-7	2021	Emodin treatment enhanced the cellular ROS burdens, on one hand, damaged dNTP pools and inhibited MTH1 function on the other.	Emodin	0-6	nudix hydrolase 1	Homo sapiens	98-102
33288199-0	2021	Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2.	Emodin	0-6	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	83-87
33288199-3	2021	We hypothesized that emodin inhibits renal tubulointerstitial fibrosis through EZH2, a histone methyltransferase.	Emodin	21-27	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	79-83
33288199-5	2021	Inhibition of EZH2 by 3-DZNeP blocked or attenuated the anti-fibrotic effect of emodin in UUO kidneys and NRK-49F cells.	Emodin	80-86	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	14-18
33288199-6	2021	These data indicate that emodin inhibits renal tubulointerstitial fibrosis in obstructed kidneys and this effect is mediated through EZH2.	Emodin	25-31	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	133-137
33403025-8	2021	Our work on emodin indicates that ROS is the key driver of cancer cell-specific increased DNA damage and apoptosis upon MTH1 inhibition.	Emodin	12-18	nudix hydrolase 1	Homo sapiens	120-124
33403025-10	2021	Conclusions: Based on our data, the anti-cancer effects of emodin as an MTH1 inhibitor have clinical potential as a single agent capable of functioning as a ROS inducer and simultaneous blocker of dNTP pool sanitation in the treatment of NSCL cancers.	Emodin	59-65	nudix hydrolase 1	Homo sapiens	72-76
33122156-0	2020	Emodin inhibited NADPH-quinone reductase competitively and induced cytotoxicity in rat primary hepatocytes.	Emodin	0-6	crystallin zeta	Rattus norvegicus	17-40
32749748-8	2021	AUR docking with the insulin receptor showed that the residues of the insulin receptor, ectodomain, were the same as those around the emodin.	Emodin	134-140	insulin receptor	Mus musculus	21-37
32749748-8	2021	AUR docking with the insulin receptor showed that the residues of the insulin receptor, ectodomain, were the same as those around the emodin.	Emodin	134-140	insulin receptor	Mus musculus	70-86
33122156-3	2020	Here, we report that Emodin, a CO anthraquinone, inhibits the enzymatic activity of NADPH-Quinone reductase, which is an intracellular enzyme fundamentally involved in the detoxification of quinone containing compounds.	Emodin	21-27	crystallin zeta	Rattus norvegicus	84-107
33122156-4	2020	Emodin binds to the active site of the enzyme and acts as a competitive inhibitor with respect to 2, 6-Dichlorophenolindophenol, a known substrate of NADPH-Quinone reductase.	Emodin	0-6	crystallin zeta	Rattus norvegicus	150-173
33205668-0	2022	The effect of emodin on melanogenesis through the modulation of ERK and MITF signaling pathway.	Emodin	14-20	mitogen-activated protein kinase 1	Mus musculus	64-67
33205668-6	2022	Moreover, emodin suppressed ERK activation by SIRT1 and FOXO1.	Emodin	10-16	mitogen-activated protein kinase 1	Mus musculus	28-31
33205668-0	2022	The effect of emodin on melanogenesis through the modulation of ERK and MITF signaling pathway.	Emodin	14-20	melanogenesis associated transcription factor	Mus musculus	72-76
33205668-6	2022	Moreover, emodin suppressed ERK activation by SIRT1 and FOXO1.	Emodin	10-16	sirtuin 1	Mus musculus	46-51
33205668-6	2022	Moreover, emodin suppressed ERK activation by SIRT1 and FOXO1.	Emodin	10-16	forkhead box O1	Mus musculus	56-61
33205668-4	2022	Emodin increased not only tyrosinase activity but also melanin synthesis in vitro.	Emodin	0-6	tyrosinase	Mus musculus	26-36
33205668-5	2022	Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence.	Emodin	10-16	tyrosinase	Mus musculus	82-92
33205668-7	2022	Thus, emodin promoted melanin synthesis by increasing the expression of TRP-1, TRP-2, tyrosinase through the activation of MITF transcription factor.	Emodin	6-12	tyrosinase-related protein 1	Mus musculus	72-77
33205668-5	2022	Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence.	Emodin	10-16	tyrosinase	Mus musculus	94-97
33205668-5	2022	Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence.	Emodin	10-16	tyrosinase-related protein 1	Mus musculus	100-132
33205668-7	2022	Thus, emodin promoted melanin synthesis by increasing the expression of TRP-1, TRP-2, tyrosinase through the activation of MITF transcription factor.	Emodin	6-12	tRNA proline 2	Mus musculus	79-84
33205668-7	2022	Thus, emodin promoted melanin synthesis by increasing the expression of TRP-1, TRP-2, tyrosinase through the activation of MITF transcription factor.	Emodin	6-12	tyrosinase	Mus musculus	86-96
33205668-7	2022	Thus, emodin promoted melanin synthesis by increasing the expression of TRP-1, TRP-2, tyrosinase through the activation of MITF transcription factor.	Emodin	6-12	melanogenesis associated transcription factor	Mus musculus	123-127
33205668-5	2022	Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence.	Emodin	10-16	tRNA proline 2	Mus musculus	134-139
33205668-5	2022	Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence.	Emodin	10-16	melanogenesis associated transcription factor	Mus musculus	141-145
33205668-5	2022	Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence.	Emodin	10-16	sirtuin 1	Mus musculus	150-155
32682817-6	2020	Mechanistic studies further reveal that EMO and BBR in combined treatment inhibited SIK3-potentiated mTOR-mediated aerobic glycolysis and cell growth in breast cancer cells.	Emodin	40-43	mechanistic target of rapamycin kinase	Homo sapiens	101-105
33167932-0	2020	Emodin protected against retinal ischemia insulted neurons through the downregulation of protein overexpression of beta-catenin and vascular endothelium factor.	Emodin	0-6	catenin beta 1	Rattus norvegicus	115-127
33167932-14	2020	CONCLUSIONS: The present results suggest that emodin might protect against retinal ischemia insulted neurons such as RGCs by significantly downregulating the upregulation of beta-catenin/VEGF protein that occurs during ischemia.	Emodin	46-52	catenin beta 1	Rattus norvegicus	174-186
33167932-14	2020	CONCLUSIONS: The present results suggest that emodin might protect against retinal ischemia insulted neurons such as RGCs by significantly downregulating the upregulation of beta-catenin/VEGF protein that occurs during ischemia.	Emodin	46-52	vascular endothelial growth factor A	Rattus norvegicus	187-191
32682817-6	2020	Mechanistic studies further reveal that EMO and BBR in combined treatment inhibited SIK3-potentiated mTOR-mediated aerobic glycolysis and cell growth in breast cancer cells.	Emodin	40-43	SIK family kinase 3	Homo sapiens	84-88
32682817-0	2020	Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway.	Emodin	14-20	SIK family kinase 3	Homo sapiens	102-106
32682817-9	2020	Collectively, our findings reveal that combination of EMO and BBR attenuates SIK3-driven tumor growth in breast cancer, and thus, EMO and BBR might be a novel SIK3 inhibitor explored into the prevention of breast cancer.	Emodin	54-57	SIK family kinase 3	Homo sapiens	77-81
32682817-9	2020	Collectively, our findings reveal that combination of EMO and BBR attenuates SIK3-driven tumor growth in breast cancer, and thus, EMO and BBR might be a novel SIK3 inhibitor explored into the prevention of breast cancer.	Emodin	130-133	SIK family kinase 3	Homo sapiens	77-81
32682817-9	2020	Collectively, our findings reveal that combination of EMO and BBR attenuates SIK3-driven tumor growth in breast cancer, and thus, EMO and BBR might be a novel SIK3 inhibitor explored into the prevention of breast cancer.	Emodin	130-133	SIK family kinase 3	Homo sapiens	159-163
32682817-0	2020	Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway.	Emodin	14-20	mechanistic target of rapamycin kinase	Homo sapiens	115-119
32682817-0	2020	Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway.	Emodin	14-20	AKT serine/threonine kinase 1	Homo sapiens	124-127
32682817-5	2020	Furthermore, our findings showed that Emodin (EMO) combined with Berberine (BBR) significantly inhibited SIK3 activity, leading to reduced cell growth, increased cell cycle arrest and apoptosis in breast cancer cells, but not in non-malignant breast epithelial cell line.	Emodin	38-44	SIK family kinase 3	Homo sapiens	105-109
32682817-5	2020	Furthermore, our findings showed that Emodin (EMO) combined with Berberine (BBR) significantly inhibited SIK3 activity, leading to reduced cell growth, increased cell cycle arrest and apoptosis in breast cancer cells, but not in non-malignant breast epithelial cell line.	Emodin	46-49	SIK family kinase 3	Homo sapiens	105-109
33182048-0	2020	Emodin improves alveolar hypercoagulation and inhibits pulmonary inflammation in LPS-provoked ARDS in mice via NF-kappaB inactivation.	Emodin	0-6	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	111-120
32777676-0	2020	Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation.	Emodin	0-6	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	19-28
32777676-3	2020	We provided in vivo evidence suggesting that intraperitoneal injection of emodin (20 mg/kg) 1 h prior to OVA challenge apparently alleviated the thickness of airway smooth muscle, the mass of alpha-smooth muscle actin (alpha-SMA), collagen deposition, epithelial damage, goblet cell hyperplasia, airway inflammation and airway hyperresponsiveness (AHR) in lung tissue.	Emodin	74-80	actin alpha 2, smooth muscle, aorta	Mus musculus	219-228
32777676-4	2020	Meanwhile, we found that emodin suppressed the activation of the Akt pathway in lungtissue of allergic mouse models.	Emodin	25-31	thymoma viral proto-oncogene 1	Mus musculus	65-68
32777676-5	2020	Additionally, we found that emodin inhibited cellular proliferation and Akt activation in a dose-dependent manner in vitro.	Emodin	28-34	thymoma viral proto-oncogene 1	Mus musculus	72-75
32777676-7	2020	These findings indicated that emodin alleviated ASMCs proliferation by inhibiting PI3K/Akt pathway in vivo and in vitro, which may provide a potential therapeutic option for airway smooth muscle remodeling in asthma.	Emodin	30-36	thymoma viral proto-oncogene 1	Mus musculus	87-90
33182048-10	2020	Expressions of TF, PAI-1, collagen I and collagen III as well as IL-8, IL-1beta and TNF-alpha in pulmonary tissue were all elevated while APC decreased under LPS provocation, which were all reversed by emodin treatment in dose-dependent manner.	Emodin	202-208	chemokine (C-X-C motif) ligand 15	Mus musculus	65-69
33182048-10	2020	Expressions of TF, PAI-1, collagen I and collagen III as well as IL-8, IL-1beta and TNF-alpha in pulmonary tissue were all elevated while APC decreased under LPS provocation, which were all reversed by emodin treatment in dose-dependent manner.	Emodin	202-208	interleukin 1 alpha	Mus musculus	71-79
33182048-3	2020	Emodin, a traditional Chinese herb, shows potent inhibitory effect on NF-kappaB pathway, but whether it is effective in alveolar hypercoagulation and pulmonary inflammation in ARDS remains to be elucidated.	Emodin	0-6	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	70-79
33182048-10	2020	Expressions of TF, PAI-1, collagen I and collagen III as well as IL-8, IL-1beta and TNF-alpha in pulmonary tissue were all elevated while APC decreased under LPS provocation, which were all reversed by emodin treatment in dose-dependent manner.	Emodin	202-208	tumor necrosis factor	Mus musculus	84-93
33182048-12	2020	Meanwhile, emodin effectively inhibited NF-kappaB pathway activation and attenuated p65 DNA binding activity induced by LPS inhalation.	Emodin	11-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	40-49
33182048-12	2020	Meanwhile, emodin effectively inhibited NF-kappaB pathway activation and attenuated p65 DNA binding activity induced by LPS inhalation.	Emodin	11-17	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	84-87
33182048-14	2020	CONCLUSIONS: Emodin improves alveolar hypercoagulation and fibrinolytic inhibition and depresses excessive pulmonary inflammation in ARDS mice in dose-dependent manner via NF-kappaB inactivation.	Emodin	13-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	172-181
33110998-2	2020	Based on the reports of emodin in hMAO inhibition and antagonist effect on the vasopressin V1A receptor, in this study we synthesized six emodin derivatives and evaluated their effects on MAO activity and G protein-coupled receptors.	Emodin	138-144	arginine vasopressin receptor 1A	Homo sapiens	79-103
32934734-0	2020	Emodin alleviates gemcitabine resistance in pancreatic cancer by inhibiting MDR1/P-glycoprotein and MRPs expression.	Emodin	0-6	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	76-80
32934734-0	2020	Emodin alleviates gemcitabine resistance in pancreatic cancer by inhibiting MDR1/P-glycoprotein and MRPs expression.	Emodin	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	81-95
32934734-12	2020	In addition, emodin treatment reduced resistance to gemcitabine, which was characterized by the downregulation of P-glycoprotein, MRP1 and MRP5 expression in the group receiving combination treatment.	Emodin	13-19	ATP binding cassette subfamily B member 1	Homo sapiens	114-128
32934734-12	2020	In addition, emodin treatment reduced resistance to gemcitabine, which was characterized by the downregulation of P-glycoprotein, MRP1 and MRP5 expression in the group receiving combination treatment.	Emodin	13-19	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	130-134
32934734-12	2020	In addition, emodin treatment reduced resistance to gemcitabine, which was characterized by the downregulation of P-glycoprotein, MRP1 and MRP5 expression in the group receiving combination treatment.	Emodin	13-19	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	Mus musculus	139-143
32934734-13	2020	The level of P-glycoprotein was also decreased in the group treated with gemcitabine+emodin compared with the single treatment groups.	Emodin	85-91	ATP binding cassette subfamily B member 1	Homo sapiens	13-27
32934734-14	2020	Taken together, these results demonstrated that emodin enhanced gemcitabine efficacy in tumor treatment and alleviated gemcitabine resistance in PANC-1 cell xenografts in mice via suppressing MDR1/P-glycoprotein and MRP expression.	Emodin	48-54	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	192-196
32934734-14	2020	Taken together, these results demonstrated that emodin enhanced gemcitabine efficacy in tumor treatment and alleviated gemcitabine resistance in PANC-1 cell xenografts in mice via suppressing MDR1/P-glycoprotein and MRP expression.	Emodin	48-54	ATP binding cassette subfamily B member 1	Homo sapiens	197-211
32934734-14	2020	Taken together, these results demonstrated that emodin enhanced gemcitabine efficacy in tumor treatment and alleviated gemcitabine resistance in PANC-1 cell xenografts in mice via suppressing MDR1/P-glycoprotein and MRP expression.	Emodin	48-54	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	216-219
32464200-1	2020	In this study, the inhibitory effects of four anthraquinones including chrysophanol, emodin, physcione and rhein on tyrosinase were investigated by enzyme inhibition assay.	Emodin	85-91	tyrosinase	Homo sapiens	116-126
33061461-0	2020	Emodin Reverses Gemcitabine Resistance of Pancreatic Cancer Cell Lines Through Inhibition of IKKbeta/NF-kappaB Signaling Pathway.	Emodin	0-6	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	93-100
33061461-0	2020	Emodin Reverses Gemcitabine Resistance of Pancreatic Cancer Cell Lines Through Inhibition of IKKbeta/NF-kappaB Signaling Pathway.	Emodin	0-6	nuclear factor kappa B subunit 1	Homo sapiens	101-110
33061461-13	2020	Emodin significantly reduced NF-kappaB activity and emodin significantly promoted P-gp fluorescence intensity from Rhodamine 123 efflux assay.	Emodin	0-6	nuclear factor kappa B subunit 1	Homo sapiens	29-38
33061461-13	2020	Emodin significantly reduced NF-kappaB activity and emodin significantly promoted P-gp fluorescence intensity from Rhodamine 123 efflux assay.	Emodin	52-58	phosphoglycolate phosphatase	Homo sapiens	82-86
33061461-14	2020	Conclusion: Emodin inhibits the expression of IKKbeta, thereby inhibiting the expression and activity of downstream NF-kappaB, and inhibits P-gp function at the same time, ultimately achieving the purpose of reversing the drug-resistance of pancreatic cancer cell lines.	Emodin	12-18	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	46-53
33061461-14	2020	Conclusion: Emodin inhibits the expression of IKKbeta, thereby inhibiting the expression and activity of downstream NF-kappaB, and inhibits P-gp function at the same time, ultimately achieving the purpose of reversing the drug-resistance of pancreatic cancer cell lines.	Emodin	12-18	nuclear factor kappa B subunit 1	Homo sapiens	116-125
33061461-14	2020	Conclusion: Emodin inhibits the expression of IKKbeta, thereby inhibiting the expression and activity of downstream NF-kappaB, and inhibits P-gp function at the same time, ultimately achieving the purpose of reversing the drug-resistance of pancreatic cancer cell lines.	Emodin	12-18	phosphoglycolate phosphatase	Homo sapiens	140-144
32437058-8	2020	Emodin reversed acetylcholine-caused increases of phosphorylation of myosin phosphatase target subunit 1 (MYPT1).	Emodin	0-6	protein phosphatase 1, regulatory subunit 12A	Mus musculus	69-104
32915230-0	2020	Emodin protects against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-kappaB pathway.	Emodin	0-6	surfactant protein A1	Rattus norvegicus	100-104
32915230-0	2020	Emodin protects against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-kappaB pathway.	Emodin	0-6	toll-like receptor 4	Rattus norvegicus	109-113
32915230-12	2020	CONCLUSION: Our findings suggested that emodin could protect against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-kappaB pathway.	Emodin	40-46	surfactant protein A1	Rattus norvegicus	145-149
32915230-12	2020	CONCLUSION: Our findings suggested that emodin could protect against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-kappaB pathway.	Emodin	40-46	toll-like receptor 4	Rattus norvegicus	154-158
31912578-8	2020	Emodin alleviated LPS-evoked inflammatory injury and restrained the NF-kappaB and p38MAPK pathways.	Emodin	0-6	nuclear factor kappa B subunit 1	Homo sapiens	68-77
31912578-9	2020	Furthermore, emodin positively regulated TUG1 expression and TUG1 silencing could reverse the efficacy of emodin on IL-6 and MCP-1 expressions.	Emodin	13-19	taurine up-regulated 1	Homo sapiens	41-45
31912578-9	2020	Furthermore, emodin positively regulated TUG1 expression and TUG1 silencing could reverse the efficacy of emodin on IL-6 and MCP-1 expressions.	Emodin	13-19	C-C motif chemokine ligand 2	Homo sapiens	125-130
31912578-9	2020	Furthermore, emodin positively regulated TUG1 expression and TUG1 silencing could reverse the efficacy of emodin on IL-6 and MCP-1 expressions.	Emodin	106-112	taurine up-regulated 1	Homo sapiens	61-65
31912578-9	2020	Furthermore, emodin positively regulated TUG1 expression and TUG1 silencing could reverse the efficacy of emodin on IL-6 and MCP-1 expressions.	Emodin	106-112	interleukin 6	Homo sapiens	116-120
31912578-9	2020	Furthermore, emodin positively regulated TUG1 expression and TUG1 silencing could reverse the efficacy of emodin on IL-6 and MCP-1 expressions.	Emodin	106-112	C-C motif chemokine ligand 2	Homo sapiens	125-130
31912578-11	2020	CONCLUSION: Emodin alleviated LPS-evoked inflammatory injury by raising TUG1 expression via NF-kappaB and p38MAPK pathways in WI-38 cells.	Emodin	12-18	taurine up-regulated 1	Homo sapiens	72-76
31912578-11	2020	CONCLUSION: Emodin alleviated LPS-evoked inflammatory injury by raising TUG1 expression via NF-kappaB and p38MAPK pathways in WI-38 cells.	Emodin	12-18	nuclear factor kappa B subunit 1	Homo sapiens	92-101
32293791-0	2020	Emodin protected against synaptic impairment and oxidative stress induced by fluoride in SH-SY5Y cells by modulating ERK1/2/Nrf2/HO-1 pathway.	Emodin	0-6	mitogen-activated protein kinase 3	Homo sapiens	117-123
32293791-0	2020	Emodin protected against synaptic impairment and oxidative stress induced by fluoride in SH-SY5Y cells by modulating ERK1/2/Nrf2/HO-1 pathway.	Emodin	0-6	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
32293791-0	2020	Emodin protected against synaptic impairment and oxidative stress induced by fluoride in SH-SY5Y cells by modulating ERK1/2/Nrf2/HO-1 pathway.	Emodin	0-6	heme oxygenase 1	Homo sapiens	129-133
32293791-5	2020	Moreover, pretreatment with emodin was used to shed light on the neuroprotective effects in NaF-induced toxicity in SH-SY5Y cells.	Emodin	28-34	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
32935466-0	2020	Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells.	Emodin	0-6	elastase, neutrophil expressed	Rattus norvegicus	18-37
32935466-0	2020	Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells.	Emodin	0-6	notch receptor 1	Rattus norvegicus	88-94
32935466-2	2020	Traditional Chinese medicine Emodin has been reported to inhibit TGF-beta-induced epithelial-mesenchymal transition (EMT) in alveolar epithelial cells through Notch signalling.	Emodin	29-35	transforming growth factor alpha	Rattus norvegicus	65-73
32935466-2	2020	Traditional Chinese medicine Emodin has been reported to inhibit TGF-beta-induced epithelial-mesenchymal transition (EMT) in alveolar epithelial cells through Notch signalling.	Emodin	29-35	notch receptor 1	Rattus norvegicus	159-164
32935466-5	2020	Traditional Chinese medicine Emodin treatment remarkably inhibited the enzyme activity of NE, suppressed EMT, Notch1 cleavage and NICD nuclear translocation within RLE-6TN and A549 cells, while NE treatment significantly reversed the effects of Emodin.	Emodin	29-35	notch receptor 1	Rattus norvegicus	110-116
32935466-6	2020	Moreover, in RLE-6TN, the effects of NE on EMT, Notch1 cleavage and NICD nuclear translocation were remarkably attenuated by Emodin treatment and more attenuated by the combination of Emodin and neutrophil elastase inhibitor Sivelestat or notch signal pathway inhibitor DAPT.	Emodin	125-131	notch receptor 1	Rattus norvegicus	48-54
32935466-7	2020	In conclusion, we revealed the involvement of NE-induced Notch1 cleavage in the functions of Emodin suppressing NE-caused EMT in RLE-6TN cells and A549 cells.	Emodin	93-99	notch receptor 1	Rattus norvegicus	57-63
32910199-0	2020	Emodin ameliorates renal injury in BXSB mice by modulating TNF-alpha/ICAM-1.	Emodin	0-6	tumor necrosis factor	Mus musculus	59-68
32910199-0	2020	Emodin ameliorates renal injury in BXSB mice by modulating TNF-alpha/ICAM-1.	Emodin	0-6	intercellular adhesion molecule 1	Mus musculus	69-75
32910199-5	2020	The results showed that the mice fed emodin presented decreases in the urinary protein content and glomerular TNF-alpha, ICAM-1 and FN levels (P<0.05).	Emodin	37-43	tumor necrosis factor	Mus musculus	110-119
32910199-5	2020	The results showed that the mice fed emodin presented decreases in the urinary protein content and glomerular TNF-alpha, ICAM-1 and FN levels (P<0.05).	Emodin	37-43	intercellular adhesion molecule 1	Mus musculus	121-127
32910199-5	2020	The results showed that the mice fed emodin presented decreases in the urinary protein content and glomerular TNF-alpha, ICAM-1 and FN levels (P<0.05).	Emodin	37-43	fibronectin 1	Mus musculus	132-134
32982173-7	2020	After treated with emodin, the migration and invasion abilities of EESs and CESs were significantly down-regulated, and the levels of integrin-linked kinase (ILK) and p-GSK-3beta were statistically down-regulated in EESs.	Emodin	19-25	integrin linked kinase	Homo sapiens	134-156
32982173-7	2020	After treated with emodin, the migration and invasion abilities of EESs and CESs were significantly down-regulated, and the levels of integrin-linked kinase (ILK) and p-GSK-3beta were statistically down-regulated in EESs.	Emodin	19-25	integrin linked kinase	Homo sapiens	158-161
32982173-7	2020	After treated with emodin, the migration and invasion abilities of EESs and CESs were significantly down-regulated, and the levels of integrin-linked kinase (ILK) and p-GSK-3beta were statistically down-regulated in EESs.	Emodin	19-25	glycogen synthase kinase 3 alpha	Homo sapiens	169-178
32982173-8	2020	Besides that, the expression of keratin was up-regulated while the expression of vimentin, beta-catenin and slug were all down-regulated by emodin in a dose- and time-dependent manner.	Emodin	140-146	vimentin	Homo sapiens	81-89
32982173-8	2020	Besides that, the expression of keratin was up-regulated while the expression of vimentin, beta-catenin and slug were all down-regulated by emodin in a dose- and time-dependent manner.	Emodin	140-146	catenin beta 1	Homo sapiens	91-103
32982173-9	2020	Silencing of ILK gene in EESs also achieved the above effects, which were strengthened by emodin.	Emodin	90-96	integrin linked kinase	Homo sapiens	13-16
32982173-10	2020	Conversely, exogenous expression of ILK in CESs increased the expression of p-GSK-3beta, which were abrogated by emodin.	Emodin	113-119	integrin linked kinase	Homo sapiens	36-39
32982173-10	2020	Conversely, exogenous expression of ILK in CESs increased the expression of p-GSK-3beta, which were abrogated by emodin.	Emodin	113-119	glycogen synthase kinase 3 alpha	Homo sapiens	78-87
32982173-12	2020	Conclusion: Emodin inhibits the migration and invasion abilities of human endometrial stromal cells by reversing the EMT via ILK/GSK-3beta pathway.	Emodin	12-18	integrin linked kinase	Homo sapiens	125-128
32982173-12	2020	Conclusion: Emodin inhibits the migration and invasion abilities of human endometrial stromal cells by reversing the EMT via ILK/GSK-3beta pathway.	Emodin	12-18	glycogen synthase kinase 3 alpha	Homo sapiens	129-138
32943844-8	2020	In addition, HGF-induced increase in collagen II expression was further enhanced by emodin.	Emodin	84-90	hepatocyte growth factor	Mus musculus	13-16
32293791-8	2020	Pretreatment with emodin significantly recovered these alterations caused by NaF.	Emodin	18-24	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
32437058-8	2020	Emodin reversed acetylcholine-caused increases of phosphorylation of myosin phosphatase target subunit 1 (MYPT1).	Emodin	0-6	protein phosphatase 1, regulatory subunit 12A	Mus musculus	106-111
32782444-6	2020	Compared to untreated rat, Emo-treated rat exhibited significantly ameliorated lung pathological changes and decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Emodin	27-30	tumor necrosis factor	Rattus norvegicus	119-146
32799401-4	2021	We provide evidence to suggest that emodin blocks Abeta42 fibrillogenesis and Abeta-induced cytotoxicity, displaying a greater effect than that of curcumin.	Emodin	36-42	amyloid beta (A4) precursor protein	Mus musculus	50-55
32799401-8	2021	Pathological results revealed that levels of Abeta deposition in the brains of AD mice treated with a high dose of emodin decreased by 50-70%.	Emodin	115-121	amyloid beta (A4) precursor protein	Mus musculus	45-50
32782444-6	2020	Compared to untreated rat, Emo-treated rat exhibited significantly ameliorated lung pathological changes and decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Emodin	27-30	tumor necrosis factor	Rattus norvegicus	148-157
32782444-6	2020	Compared to untreated rat, Emo-treated rat exhibited significantly ameliorated lung pathological changes and decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Emodin	27-30	interleukin 1 beta	Rattus norvegicus	163-180
32782444-6	2020	Compared to untreated rat, Emo-treated rat exhibited significantly ameliorated lung pathological changes and decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Emodin	27-30	interleukin 1 alpha	Rattus norvegicus	182-190
32832542-0	2020	Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3beta Pathway in Neuroblastoma SH-SY5Y Cells.	Emodin	0-6	mechanistic target of rapamycin kinase	Homo sapiens	131-135
32832542-0	2020	Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3beta Pathway in Neuroblastoma SH-SY5Y Cells.	Emodin	0-6	glycogen synthase kinase 3 alpha	Homo sapiens	136-144
32832542-6	2020	Simultaneously, emodin downregulated H2O2-induced inflammatory factors, including IL-6, NO, and TNF-alpha, and alleviated H2O2-induced oxidative stress and mitochondrial dysfunction in SH-SY5Y cells.	Emodin	16-22	interleukin 6	Homo sapiens	82-86
32832542-6	2020	Simultaneously, emodin downregulated H2O2-induced inflammatory factors, including IL-6, NO, and TNF-alpha, and alleviated H2O2-induced oxidative stress and mitochondrial dysfunction in SH-SY5Y cells.	Emodin	16-22	tumor necrosis factor	Homo sapiens	96-105
32832542-7	2020	In addition, emodin inhibited the activation of the PI3K/mTOR/GSK3beta signaling pathway.	Emodin	13-19	mechanistic target of rapamycin kinase	Homo sapiens	57-61
32832542-7	2020	In addition, emodin inhibited the activation of the PI3K/mTOR/GSK3beta signaling pathway.	Emodin	13-19	glycogen synthase kinase 3 alpha	Homo sapiens	62-70
32832542-9	2020	Collectively, it suggests that emodin alleviates H2O2-induced apoptosis and neuroinflammation potentially by regulating the PI3K/mTOR/GSK3beta signaling pathway.	Emodin	31-37	mechanistic target of rapamycin kinase	Homo sapiens	129-133
32832542-9	2020	Collectively, it suggests that emodin alleviates H2O2-induced apoptosis and neuroinflammation potentially by regulating the PI3K/mTOR/GSK3beta signaling pathway.	Emodin	31-37	glycogen synthase kinase 3 alpha	Homo sapiens	134-142
32765495-0	2020	Corrigendum: A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection.	Emodin	46-52	CD4 antigen	Mus musculus	66-69
32765495-0	2020	Corrigendum: A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection.	Emodin	46-52	forkhead box P3	Mus musculus	70-75
32765495-0	2020	Corrigendum: A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection.	Emodin	46-52	interleukin 2 receptor, beta chain	Mus musculus	85-90
32115640-0	2020	Effect of Emodin on Coxsackievirus B3m-Mediated Encephalitis in Hand, Foot, and Mouth Disease by Inhibiting Toll-Like Receptor 3 Pathway In Vitro and In Vivo.	Emodin	10-16	toll like receptor 3	Homo sapiens	108-128
32115640-12	2020	Emodin also displayed notable effects on pathology, TLR3 protein in brain tissues, and expression of IL-6, NF-kappaB, IFN-beta, in serum.	Emodin	0-6	toll like receptor 3	Homo sapiens	52-56
32115640-12	2020	Emodin also displayed notable effects on pathology, TLR3 protein in brain tissues, and expression of IL-6, NF-kappaB, IFN-beta, in serum.	Emodin	0-6	interleukin 6	Homo sapiens	101-105
32115640-12	2020	Emodin also displayed notable effects on pathology, TLR3 protein in brain tissues, and expression of IL-6, NF-kappaB, IFN-beta, in serum.	Emodin	0-6	IFN1@	Homo sapiens	118-126
32115640-13	2020	CONCLUSIONS: Emodin exerts a protective effect in CVB3-mediated encephalitis in HFMD by inhibiting the TLR3 pathway.	Emodin	13-19	toll like receptor 3	Homo sapiens	103-107
32346413-8	2020	The results showed that the pathological damage to intestinal mucosa and the intestinal tissue injury score in the CLP + emodin group were significantly reduced compared to those of the CLP group, and the differences were more obvious at 24 h compared with 12 h. DAO activity and the L/M ratio in the emodin pre-treatment group decreased significantly at 24 h compared with the CLP groups.	Emodin	121-127	amine oxidase, copper containing 1	Rattus norvegicus	263-266
32346413-8	2020	The results showed that the pathological damage to intestinal mucosa and the intestinal tissue injury score in the CLP + emodin group were significantly reduced compared to those of the CLP group, and the differences were more obvious at 24 h compared with 12 h. DAO activity and the L/M ratio in the emodin pre-treatment group decreased significantly at 24 h compared with the CLP groups.	Emodin	301-307	amine oxidase, copper containing 1	Rattus norvegicus	263-266
32546964-0	2020	Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.	Emodin	0-6	NFE2 like bZIP transcription factor 2	Rattus norvegicus	114-118
32546964-0	2020	Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.	Emodin	0-6	heme oxygenase 1	Rattus norvegicus	119-123
32546964-11	2020	Emodin administration suppressed the production of proinflammatory cytokines, downregulated NLRP3, ASC and caspase-1 expressions and inhibited NF-kappaB nuclear accumulation in the lung.	Emodin	0-6	NLR family, pyrin domain containing 3	Rattus norvegicus	92-97
32546964-11	2020	Emodin administration suppressed the production of proinflammatory cytokines, downregulated NLRP3, ASC and caspase-1 expressions and inhibited NF-kappaB nuclear accumulation in the lung.	Emodin	0-6	PYD and CARD domain containing	Rattus norvegicus	99-102
32546964-11	2020	Emodin administration suppressed the production of proinflammatory cytokines, downregulated NLRP3, ASC and caspase-1 expressions and inhibited NF-kappaB nuclear accumulation in the lung.	Emodin	0-6	caspase 1	Rattus norvegicus	107-116
32546964-13	2020	Moreover, the anti-inflammatory effect of emodin was blocked by Nrf2 inhibitor ML385.	Emodin	42-48	NFE2 like bZIP transcription factor 2	Rattus norvegicus	64-68
32546964-14	2020	Conclusion: Emodin effectively protects rats against AP-associated lung injury by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.	Emodin	12-18	NLR family, pyrin domain containing 3	Rattus norvegicus	93-98
32546964-14	2020	Conclusion: Emodin effectively protects rats against AP-associated lung injury by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.	Emodin	12-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	127-131
32546964-14	2020	Conclusion: Emodin effectively protects rats against AP-associated lung injury by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.	Emodin	12-18	heme oxygenase 1	Rattus norvegicus	132-136
32130427-0	2020	Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1alpha/VEGF signaling pathway.	Emodin	0-6	mechanistic target of rapamycin kinase	Rattus norvegicus	107-111
32130427-0	2020	Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1alpha/VEGF signaling pathway.	Emodin	0-6	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	112-122
32130427-0	2020	Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1alpha/VEGF signaling pathway.	Emodin	0-6	vascular endothelial growth factor A	Rattus norvegicus	123-127
32130427-1	2020	OBJECTIVE AND DESIGN: This study aimed to investigate the anti-pulmonary inflammation effect of emodin on Wistar rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and RAW264.7 cells through the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) signaling pathway.	Emodin	96-102	mechanistic target of rapamycin kinase	Homo sapiens	211-240
32130427-1	2020	OBJECTIVE AND DESIGN: This study aimed to investigate the anti-pulmonary inflammation effect of emodin on Wistar rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and RAW264.7 cells through the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) signaling pathway.	Emodin	96-102	mechanistic target of rapamycin kinase	Homo sapiens	242-246
32130427-1	2020	OBJECTIVE AND DESIGN: This study aimed to investigate the anti-pulmonary inflammation effect of emodin on Wistar rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and RAW264.7 cells through the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) signaling pathway.	Emodin	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	248-279
32130427-1	2020	OBJECTIVE AND DESIGN: This study aimed to investigate the anti-pulmonary inflammation effect of emodin on Wistar rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and RAW264.7 cells through the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) signaling pathway.	Emodin	96-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	281-291
32130427-1	2020	OBJECTIVE AND DESIGN: This study aimed to investigate the anti-pulmonary inflammation effect of emodin on Wistar rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and RAW264.7 cells through the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) signaling pathway.	Emodin	96-102	vascular endothelial growth factor A	Homo sapiens	293-327
32130427-1	2020	OBJECTIVE AND DESIGN: This study aimed to investigate the anti-pulmonary inflammation effect of emodin on Wistar rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and RAW264.7 cells through the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) signaling pathway.	Emodin	96-102	vascular endothelial growth factor A	Homo sapiens	329-333
32130427-13	2020	CONCLUSION: Emodin alleviated LPS-induced pulmonary inflammation in rat lung tissues and RAW264.7 cells through inhibiting the mTOR/HIF-1alpha/VEGF signaling pathway, which accounted for the therapeutic effects of emodin on ALI.	Emodin	12-18	mechanistic target of rapamycin kinase	Mus musculus	127-131
32130427-13	2020	CONCLUSION: Emodin alleviated LPS-induced pulmonary inflammation in rat lung tissues and RAW264.7 cells through inhibiting the mTOR/HIF-1alpha/VEGF signaling pathway, which accounted for the therapeutic effects of emodin on ALI.	Emodin	12-18	hypoxia inducible factor 1, alpha subunit	Mus musculus	132-142
32130427-13	2020	CONCLUSION: Emodin alleviated LPS-induced pulmonary inflammation in rat lung tissues and RAW264.7 cells through inhibiting the mTOR/HIF-1alpha/VEGF signaling pathway, which accounted for the therapeutic effects of emodin on ALI.	Emodin	12-18	vascular endothelial growth factor A	Mus musculus	143-147
32130427-13	2020	CONCLUSION: Emodin alleviated LPS-induced pulmonary inflammation in rat lung tissues and RAW264.7 cells through inhibiting the mTOR/HIF-1alpha/VEGF signaling pathway, which accounted for the therapeutic effects of emodin on ALI.	Emodin	214-220	mechanistic target of rapamycin kinase	Mus musculus	127-131
32130427-13	2020	CONCLUSION: Emodin alleviated LPS-induced pulmonary inflammation in rat lung tissues and RAW264.7 cells through inhibiting the mTOR/HIF-1alpha/VEGF signaling pathway, which accounted for the therapeutic effects of emodin on ALI.	Emodin	214-220	hypoxia inducible factor 1, alpha subunit	Mus musculus	132-142
32130427-13	2020	CONCLUSION: Emodin alleviated LPS-induced pulmonary inflammation in rat lung tissues and RAW264.7 cells through inhibiting the mTOR/HIF-1alpha/VEGF signaling pathway, which accounted for the therapeutic effects of emodin on ALI.	Emodin	214-220	vascular endothelial growth factor A	Mus musculus	143-147
30924024-0	2020	Emodin induced necroptosis in the glioma cell line U251 via the TNF-alpha/RIP1/RIP3 pathway.	Emodin	0-6	tumor necrosis factor	Homo sapiens	64-73
30924024-0	2020	Emodin induced necroptosis in the glioma cell line U251 via the TNF-alpha/RIP1/RIP3 pathway.	Emodin	0-6	receptor interacting serine/threonine kinase 1	Homo sapiens	74-78
30924024-0	2020	Emodin induced necroptosis in the glioma cell line U251 via the TNF-alpha/RIP1/RIP3 pathway.	Emodin	0-6	myosin phosphatase Rho interacting protein	Homo sapiens	79-83
30924024-3	2020	This study aimed to investigate the effects and mechanisms of emodin-induced necroptosis in the glioma cell line U251 by targeting the TNF-alpha/RIP1/RIP3 signaling pathway.	Emodin	62-68	tumor necrosis factor	Homo sapiens	135-144
30924024-3	2020	This study aimed to investigate the effects and mechanisms of emodin-induced necroptosis in the glioma cell line U251 by targeting the TNF-alpha/RIP1/RIP3 signaling pathway.	Emodin	62-68	receptor interacting serine/threonine kinase 1	Homo sapiens	145-149
30924024-3	2020	This study aimed to investigate the effects and mechanisms of emodin-induced necroptosis in the glioma cell line U251 by targeting the TNF-alpha/RIP1/RIP3 signaling pathway.	Emodin	62-68	myosin phosphatase Rho interacting protein	Homo sapiens	150-154
30924024-7	2020	Furthermore, the RIP1 inhibitor Nec-1 and the RIP3 inhibitor GSK872 attenuated the killing effect of emodin on U251 cells.	Emodin	101-107	receptor interacting serine/threonine kinase 1	Homo sapiens	17-21
30924024-7	2020	Furthermore, the RIP1 inhibitor Nec-1 and the RIP3 inhibitor GSK872 attenuated the killing effect of emodin on U251 cells.	Emodin	101-107	proprotein convertase subtilisin/kexin type 1	Homo sapiens	32-37
30924024-7	2020	Furthermore, the RIP1 inhibitor Nec-1 and the RIP3 inhibitor GSK872 attenuated the killing effect of emodin on U251 cells.	Emodin	101-107	myosin phosphatase Rho interacting protein	Homo sapiens	46-50
30924024-8	2020	In addition, emodin could increase the levels of TNF-alpha, RIP1, RIP3 and MLKL in vivo.	Emodin	13-19	tumor necrosis factor	Homo sapiens	49-58
30924024-8	2020	In addition, emodin could increase the levels of TNF-alpha, RIP1, RIP3 and MLKL in vivo.	Emodin	13-19	receptor interacting serine/threonine kinase 1	Homo sapiens	60-64
30924024-8	2020	In addition, emodin could increase the levels of TNF-alpha, RIP1, RIP3 and MLKL in vivo.	Emodin	13-19	myosin phosphatase Rho interacting protein	Homo sapiens	66-70
30924024-8	2020	In addition, emodin could increase the levels of TNF-alpha, RIP1, RIP3 and MLKL in vivo.	Emodin	13-19	mixed lineage kinase domain like pseudokinase	Homo sapiens	75-79
30924024-9	2020	The results demonstrate that emodin could induce necroptosis in glioma possibly through the activation of the TNF-alpha/RIP1/RIP3 axis.	Emodin	29-35	tumor necrosis factor	Homo sapiens	110-119
30924024-9	2020	The results demonstrate that emodin could induce necroptosis in glioma possibly through the activation of the TNF-alpha/RIP1/RIP3 axis.	Emodin	29-35	receptor interacting serine/threonine kinase 1	Homo sapiens	120-124
30924024-9	2020	The results demonstrate that emodin could induce necroptosis in glioma possibly through the activation of the TNF-alpha/RIP1/RIP3 axis.	Emodin	29-35	myosin phosphatase Rho interacting protein	Homo sapiens	125-129
31934719-12	2020	Osteoclast formation and serum C-terminal cross-linked peptide (CTX) and tumor necrosis factor alpha (TNF-alpha) were also inhibited by emodin (P<0.05).	Emodin	136-142	tumor necrosis factor	Rattus norvegicus	73-100
31934719-12	2020	Osteoclast formation and serum C-terminal cross-linked peptide (CTX) and tumor necrosis factor alpha (TNF-alpha) were also inhibited by emodin (P<0.05).	Emodin	136-142	tumor necrosis factor	Rattus norvegicus	102-111
31934719-13	2020	Emodin significantly abolished IBD-enhanced Traf6, NFATC1 and c-fos expression.	Emodin	0-6	TNF receptor associated factor 6	Rattus norvegicus	44-49
31934719-13	2020	Emodin significantly abolished IBD-enhanced Traf6, NFATC1 and c-fos expression.	Emodin	0-6	nuclear factor of activated T-cells 1	Rattus norvegicus	51-57
31934719-13	2020	Emodin significantly abolished IBD-enhanced Traf6, NFATC1 and c-fos expression.	Emodin	0-6	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-67
32538071-0	2020	Metabolism and toxicity of emodin: Genome-wide association studies reveal hepatocyte nuclear factor 4alpha regulates UGT2B7 and emodin glucuronidation.	Emodin	27-33	hepatocyte nuclear factor 4 alpha	Homo sapiens	74-106
32538071-0	2020	Metabolism and toxicity of emodin: Genome-wide association studies reveal hepatocyte nuclear factor 4alpha regulates UGT2B7 and emodin glucuronidation.	Emodin	27-33	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	117-123
32538071-2	2020	Our previous studies demonstrated that genetic polymorphisms of UDP-Glucuronosyltransferase 2B7 (UGT2B7) had an effect on the glucuronidation and detoxification of emodin.	Emodin	164-170	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	64-95
32538071-2	2020	Our previous studies demonstrated that genetic polymorphisms of UDP-Glucuronosyltransferase 2B7 (UGT2B7) had an effect on the glucuronidation and detoxification of emodin.	Emodin	164-170	UDP glucuronosyltransferase family 2 member B7	Rattus norvegicus	97-103
32538071-3	2020	This study aimed to reveal the transcriptional regulation mechanism of UGT2B7 on emodin glucuronidation, and its effect on toxicity.	Emodin	81-87	UDP glucuronosyltransferase family 2 member B7	Rattus norvegicus	71-77
32538071-11	2020	Besides, HNF4A and UGT2B7 were decreased both in HepG2 cells and rats after treatment with emodin.	Emodin	91-97	hepatic nuclear factor 4, alpha	Mus musculus	9-14
32538071-11	2020	Besides, HNF4A and UGT2B7 were decreased both in HepG2 cells and rats after treatment with emodin.	Emodin	91-97	UDP glucuronosyltransferase family 2 member B7	Rattus norvegicus	19-25
32538071-12	2020	In conclusion, we demonstrated that emodin used in long-term or high-dose can inhibit the expression of HNF4A, thereby reducing the expression of UGT2B7 and causing hepatotoxicity.	Emodin	36-42	hepatocyte nuclear factor 4, alpha	Rattus norvegicus	104-109
32538071-12	2020	In conclusion, we demonstrated that emodin used in long-term or high-dose can inhibit the expression of HNF4A, thereby reducing the expression of UGT2B7 and causing hepatotoxicity.	Emodin	36-42	UDP glucuronosyltransferase family 2 member B7	Rattus norvegicus	146-152
32724475-4	2020	Cell culture and co-culture studies were performed to test if emodin suppresses TGF-beta1 or macrophage-induced EMT and CSC formation of breast cancer cells, and if it inhibits breast cancer cell migration and invasion.	Emodin	62-68	transforming growth factor beta 1	Homo sapiens	80-89
32724475-6	2020	The effects of emodin on TGF-beta1 signaling pathways in breast cancer cells were examined by western blots and immunofluorescent imaging.	Emodin	15-21	transforming growth factor beta 1	Homo sapiens	25-34
32724475-10	2020	Mechanistic studies revealed that emodin inhibited both canonical and noncanonical TGF-beta1 signaling pathways in breast cancer cells and suppressed transcription factors key to EMT and CSC.	Emodin	34-40	transforming growth factor beta 1	Homo sapiens	83-92
32724475-11	2020	Conclusion: Natural compound emodin suppresses EMT and CSC formation of breast cancer cells by blocking TGF-beta1-mediated crosstalk between TAMs and breast cancer cells.	Emodin	29-35	transforming growth factor beta 1	Homo sapiens	104-113
32568687-9	2020	However compounds like emodin that inhibit SARS entry, apparently by binding ACE2, might also have functions at several different human protein binding sites.	Emodin	23-29	angiotensin converting enzyme 2	Homo sapiens	77-81
32550907-0	2020	Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.	Emodin	13-19	vascular endothelial growth factor A	Mus musculus	72-77
32550907-12	2020	We also identified nuclear receptor corepressor 2 (NCOR2) to be the direct target of emodin.	Emodin	85-91	nuclear receptor co-repressor 2	Mus musculus	19-49
32550907-12	2020	We also identified nuclear receptor corepressor 2 (NCOR2) to be the direct target of emodin.	Emodin	85-91	nuclear receptor co-repressor 2	Mus musculus	51-56
32509181-12	2020	In addition, the combination treatment (emodin plus 5-Fu) induced cell apoptosis via inhibiting Bcl-2 and activating cleaved caspase3 and Bax.	Emodin	40-46	BCL2 apoptosis regulator	Homo sapiens	96-101
32509181-12	2020	In addition, the combination treatment (emodin plus 5-Fu) induced cell apoptosis via inhibiting Bcl-2 and activating cleaved caspase3 and Bax.	Emodin	40-46	caspase 3	Homo sapiens	125-133
32509181-12	2020	In addition, the combination treatment (emodin plus 5-Fu) induced cell apoptosis via inhibiting Bcl-2 and activating cleaved caspase3 and Bax.	Emodin	40-46	BCL2 associated X, apoptosis regulator	Homo sapiens	138-141
32509181-15	2020	CONCLUSION: Our research revealed that emodin could reverse 5-Fu resistance in CRC through inactivating PI3K/Akt signaling pathway in vitro and in vivo.	Emodin	39-45	AKT serine/threonine kinase 1	Homo sapiens	109-112
32326191-0	2020	Neuroprotective Effects of Emodin against Ischemia/Reperfusion Injury through Activating ERK-1/2 Signaling Pathway.	Emodin	27-33	mitogen activated protein kinase 3	Rattus norvegicus	89-96
32326191-12	2020	CONCLUSION: Emodin induced Bcl-2 and GLT-1 expression to inhibit neuronal apoptosis and ROS generation while reducing glutamate toxicity via the ERK-1/2 signaling pathway.	Emodin	12-18	BCL2, apoptosis regulator	Rattus norvegicus	27-32
32326191-12	2020	CONCLUSION: Emodin induced Bcl-2 and GLT-1 expression to inhibit neuronal apoptosis and ROS generation while reducing glutamate toxicity via the ERK-1/2 signaling pathway.	Emodin	12-18	solute carrier family 1 member 2	Rattus norvegicus	37-42
32326191-12	2020	CONCLUSION: Emodin induced Bcl-2 and GLT-1 expression to inhibit neuronal apoptosis and ROS generation while reducing glutamate toxicity via the ERK-1/2 signaling pathway.	Emodin	12-18	mitogen activated protein kinase 3	Rattus norvegicus	145-152
32326191-14	2020	Emodin has neuroprotective effects against ischemia/reperfusion injury both in vitro and in vivo, which may be through activating the ERK-1/2 signaling pathway.	Emodin	0-6	mitogen activated protein kinase 3	Rattus norvegicus	134-141
32023704-0	2020	[Effect of emodin on TLR4 signaling pathway in acute liver injury in animal model].	Emodin	11-17	toll like receptor 4	Homo sapiens	21-25