PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19073120-2	2007	Bromhexine in methanol/0.1molL(-1) Britton-Robinson buffer solution (2.5/97.5) shows an anodic response on glassy carbon electrode between pH 2 and 7.5.	Bromhexine	0-10	polyhomeotic homolog 2	Homo sapiens	139-143
18696263-7	2009	Pretreatment of the immobilized mucin with ambroxol, bromhexine, ammonium chloride, or ammonium acetate reduced the adherence of Pseudomonas aeruginosa, Escherichia coli, and staphylococcal isolates to this receptor analogue.	Bromhexine	53-63	LOC100508689	Homo sapiens	32-37
11167983-4	2000	Increased IFN-gamma release was observed following in vitro challenge of the patient"s lymphocytes with paracetamol or bromhexine (110% and 157% increase, respectively).	Bromhexine	119-129	interferon gamma	Homo sapiens	10-19
14534155-3	2003	This study was planned in order to investigate if ambroxol and its precursor bromhexine are actually capable of preventing alpha-1-antitrypsin (A1AT) inactivation by stimulated neutrophils and possibly to look into the mechanisms underlying this event.	Bromhexine	77-87	serpin family A member 1	Homo sapiens	123-142
14534155-3	2003	This study was planned in order to investigate if ambroxol and its precursor bromhexine are actually capable of preventing alpha-1-antitrypsin (A1AT) inactivation by stimulated neutrophils and possibly to look into the mechanisms underlying this event.	Bromhexine	77-87	serpin family A member 1	Homo sapiens	144-148
35521985-6	2022	Bromhexine is a specific TMPRSS2 inhibitor that potentially inhibits the infectivity cycle of SARS-CoV-2.	Bromhexine	0-10	transmembrane serine protease 2	Homo sapiens	25-32
10933553-1	2000	The mucolitic bromhexine [N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexylamine] has been determined in cotrimoxazole-containing tablets by partial least-squares (PLS-1) multivariate of spectrophotometric calibration data in the spectral range 310-350 nm.	Bromhexine	14-24	plastin 1	Homo sapiens	163-168
18967655-2	1999	The mucolitic bromhexine [N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexylamine] has been determined in cough suppressant syrups by multivariate spectrophotometric calibration, together with partial least-squares (PLS-1) and hybrid linear analysis (HLA).	Bromhexine	14-24	plastin 1	Homo sapiens	214-219
34787160-4	2021	Thus, four potential drugs (bromhexine, camostat, gabexate, and nafamostat) were used to explore the mechanism of binding with TMPRSS2 in this work.	Bromhexine	28-38	transmembrane serine protease 2	Homo sapiens	127-134
8831801-4	1996	The reaction constants of hydroxyl radicals with bromhexine and ambroxol were determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1 and 1.04 +/- 0.1 x 10(10) M-1S-1, respectively.	Bromhexine	49-59	tumor associated calcium signal transducer 2	Homo sapiens	142-154
8831801-4	1996	The reaction constants of hydroxyl radicals with bromhexine and ambroxol were determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1 and 1.04 +/- 0.1 x 10(10) M-1S-1, respectively.	Bromhexine	49-59	tumor associated calcium signal transducer 2	Homo sapiens	142-148
2046285-1	1991	The influence of bromhexine hydrochloride on the excretion of the lacrimal fluid in rabbits was investigated by means of lysozyme test.	Bromhexine	17-41	lysozyme C-like	Oryctolagus cuniculus	121-129
34075338-0	2021	Structural insights and inhibition mechanism of TMPRSS2 by experimentally known inhibitors Camostat mesylate, Nafamostat and Bromhexine hydrochloride to control SARS-coronavirus-2: A molecular modeling approach.	Bromhexine	125-149	transmembrane serine protease 2	Homo sapiens	48-55
34075338-5	2021	Hence, we have used a molecular dynamics (MD) simulated homology model of TMPRSS2 to study the inhibition mechanism of experimentally known inhibitors Camostat mesylate, Nafamostat and Bromhexine hydrochloride (BHH) using molecular modeling techniques.	Bromhexine	185-209	transmembrane serine protease 2	Homo sapiens	74-81
34075338-5	2021	Hence, we have used a molecular dynamics (MD) simulated homology model of TMPRSS2 to study the inhibition mechanism of experimentally known inhibitors Camostat mesylate, Nafamostat and Bromhexine hydrochloride (BHH) using molecular modeling techniques.	Bromhexine	211-214	transmembrane serine protease 2	Homo sapiens	74-81
34075338-7	2021	Molecular docking analysis revealed that Camostat mesylate and its structural analogue Nafamostat interact strongly with residues His296 and Ser441 present in the catalytic triad of TMPRSS2, whereas BHH binds with Ala386 along with other residues.	Bromhexine	199-202	transmembrane serine protease 2	Homo sapiens	182-189
35487151-0	2022	Inhibitory mechanism of Ambroxol and Bromhexine Hydrochlorides as potent blockers of molecular interaction between SARS-CoV-2 spike protein and human angiotensin-converting Enzyme-2.	Bromhexine	37-62	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	126-131
35487151-0	2022	Inhibitory mechanism of Ambroxol and Bromhexine Hydrochlorides as potent blockers of molecular interaction between SARS-CoV-2 spike protein and human angiotensin-converting Enzyme-2.	Bromhexine	37-62	angiotensin converting enzyme 2	Homo sapiens	150-181
35487151-7	2022	However, the binding of AMB (-56.931 kcal/mol) and BHH (-46.354 kcal/mol) at the exopeptidase site of hACE-2, significantly reduced the binding affinities between the proteins compared to the unbound, ACE-2-RBD complex (-64.856 kcal/mol).	Bromhexine	51-54	angiotensin converting enzyme 2	Homo sapiens	102-108
35487151-7	2022	However, the binding of AMB (-56.931 kcal/mol) and BHH (-46.354 kcal/mol) at the exopeptidase site of hACE-2, significantly reduced the binding affinities between the proteins compared to the unbound, ACE-2-RBD complex (-64.856 kcal/mol).	Bromhexine	51-54	angiotensin converting enzyme 2	Homo sapiens	201-206
35487151-9	2022	Residue interaction networks analysis further revealed the binding of the two drugs at the exopeptidase site of hACE-2 reduced the number of interacting amino residues, subsequently leading to loss of interactions between the two proteins, with BHH showing better reduction in the molecular interaction and binding affinity than AMB.	Bromhexine	245-248	angiotensin converting enzyme 2	Homo sapiens	112-118
35521985-8	2022	The findings of these studies have shown that bromhexine is effective in improving the clinical outcomes of COVID-19 and has prophylactic effects by inhibiting TMPRSS2 and viral penetration into the host cells.	Bromhexine	46-56	transmembrane serine protease 2	Homo sapiens	160-167
3518290-2	1986	Stimulation of the surfactant production in fetal cells by ambroxol (metabolite VIII of bromhexine) has been investigated in human and animal experiments.	Bromhexine	88-98	cytochrome c oxidase subunit 8A	Homo sapiens	80-84
2789651-8	1989	Patients responding to and continuously treated with bromhexine (2/3 of patients) improved significantly (P less than 0.05) in rose bengal score, but had increasing levels of p-IgG.	Bromhexine	53-63	phosphatidylinositol glycan anchor biosynthesis class G	Homo sapiens	175-180
3552853-2	1987	In a randomized open multicenter study the results of antenatal prophylaxis against neonatal RDS by administration of betamethasone were compared with those obtained with the bromhexine VIII metabolite Ambroxol.	Bromhexine	175-185	cytochrome c oxidase subunit 8A	Homo sapiens	186-190
35103059-1	2022	Background: Bromhexine hydrochloride has been suggested as a TMPRSS2 protease blocker that precludes the penetration of SARS-CoV-2 into cells.	Bromhexine	12-36	transmembrane serine protease 2	Homo sapiens	61-68
6688451-1	1983	An experimental study with metabolite VIII of bromhexine (Ambroxol).	Bromhexine	46-56	cytochrome c oxidase subunit 8A	Homo sapiens	38-42
3924041-2	1985	Bromhexine was found to exert beneficial effects on the disturbances of pulmonary function that might be caused by a reduced surfactant production observed during thrombin-induced disseminated intravascular coagulation in rats.	Bromhexine	0-10	coagulation factor II	Rattus norvegicus	163-171
7414106-0	1980	Application of bromhexine metabolite VIII (NA 872) and bromhexine-glucose in treatment of adult respiratory distress syndrome; experimental and clinical results .	Bromhexine	15-25	cytochrome c oxidase subunit 8A	Homo sapiens	37-41
7414106-1	1980	The authors study the changes in cardiopulmonary function after application of bromhexine metabolite VIII (NA 872) in an animal model of adult respiratory distress syndrome (ARDS) and bromhexine glucose solution (BGS) in ARDS patients.	Bromhexine	79-89	cytochrome c oxidase subunit 8A	Homo sapiens	101-105
582470-1	1979	The authors study the influence of bromhexine metabolite VIII on phospholipid and fatty acid composition comparatively to controls.	Bromhexine	35-45	cytochrome c oxidase subunit 8A	Homo sapiens	57-61
400861-0	1978	Surfactant in the amniotic fluid and bromhexine metabolite VIII.	Bromhexine	37-47	cytochrome c oxidase subunit 8A	Homo sapiens	59-63
33996911-1	2021	Camostat, nafamostat, and bromhexine are inhibitors of the transmembrane serine protease TMPRSS2.	Bromhexine	26-36	transmembrane serine protease 2	Homo sapiens	89-96
581993-0	1978	[Inhalation therapy with the new antisecretory drug ambroxol (metabolite VIII of bromhexine) in otorhinolaryngology].	Bromhexine	81-91	cytochrome c oxidase subunit 8A	Homo sapiens	73-77
242957-0	1977	[Prevention and therapy of respiratory distress syndrome in premature infants by means of bromhexine metabolite VIII.	Bromhexine	90-100	cytochrome c oxidase subunit 8A	Homo sapiens	112-116
242957-1	1977	Animal experimental studies on the therapeutic efficacy of bromhexine metabolite VIII in premature respiratory distress syndrome].	Bromhexine	59-69	cytochrome c oxidase subunit 8A	Homo sapiens	81-85
242957-2	1977	In preparing a clinical study 14C-labelled bromhexine metabolite VIII was applied intraamnially in animal experiments.	Bromhexine	43-53	cytochrome c oxidase subunit 8A	Homo sapiens	65-69
1174081-2	1975	Results from experimental studies in animals with the metabolite VIII of bromhexine (N-[trans-4-hydroxy-cyclohexyl]=[2-amino-3,5-dibromo-benzyl]-amine, Ambroxol (NA 842)) are described in order to contribute to the understanding of this substance"s mode of action.	Bromhexine	73-83	cytochrome c oxidase subunit 8A	Homo sapiens	65-69
1056119-0	1975	[Electron microscopy studies on the effect of metabilite VIII of Bisolvon on the fetal lung (18th and 20th day a.p.	Bromhexine	65-73	cytochrome c oxidase subunit 8A	Homo sapiens	57-61
808230-4	1975	It could be ascertained that sensitizing with human albumin and simultaneous application of Bisolvon led to a higher concentration of antibodies against albumin than did sensitizing with human albumin alone.	Bromhexine	92-100	albumin	Homo sapiens	153-160
808230-4	1975	It could be ascertained that sensitizing with human albumin and simultaneous application of Bisolvon led to a higher concentration of antibodies against albumin than did sensitizing with human albumin alone.	Bromhexine	92-100	albumin	Homo sapiens	153-160
33608407-10	2021	Paradoxically, Bromhexine enhanced cell-cell fusion in the presence of TMPRSS2, while its metabolite Ambroxol exhibited inhibitory activity in some conditions.	Bromhexine	15-25	transmembrane serine protease 2	Homo sapiens	71-78
33608407-13	2021	Bromhexine, reportedly an inhibitor of TMPRSS2, is currently tested in clinical trials against coronavirus disease 2019.	Bromhexine	0-10	transmembrane serine protease 2	Homo sapiens	39-46
33608407-15	2021	We therefore caution against use of Bromhexine in higher dosage until its effects on SARS-CoV-2 spike activation are better understood.	Bromhexine	36-46	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	96-101
20031363-1	2010	(E)-4-hydroxydemethylbromhexine (E-4-HDMB) and (E)-3-hydroxydemethylbromhexine (E-3-HDMB) were found as major metabolites, while (Z)-4-hydroxydemethylbromhexine and (Z)-3-hydroxydemethylbromhexine as minor metabolites of bromhexine in human plasma.	Bromhexine	21-31	ubiquitination factor E4A	Homo sapiens	33-41
32995775-4	2020	Herein, we discovered that Ambroxol hydrochloride (AMB), and its progenitor, Bromhexine hydrochloride (BHH), both clinically approved drugs are potent effective modulators of the key interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and human ACE2.	Bromhexine	77-101	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	251-256
32995775-4	2020	Herein, we discovered that Ambroxol hydrochloride (AMB), and its progenitor, Bromhexine hydrochloride (BHH), both clinically approved drugs are potent effective modulators of the key interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and human ACE2.	Bromhexine	77-101	angiotensin converting enzyme 2	Homo sapiens	275-279
32995775-4	2020	Herein, we discovered that Ambroxol hydrochloride (AMB), and its progenitor, Bromhexine hydrochloride (BHH), both clinically approved drugs are potent effective modulators of the key interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and human ACE2.	Bromhexine	103-106	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	251-256
32995775-4	2020	Herein, we discovered that Ambroxol hydrochloride (AMB), and its progenitor, Bromhexine hydrochloride (BHH), both clinically approved drugs are potent effective modulators of the key interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and human ACE2.	Bromhexine	103-106	angiotensin converting enzyme 2	Homo sapiens	275-279
32824674-6	2020	Clinical studies on TMPRSS2 inhibitors, such as camostat, nafamostat, and bromhexine, are ongoing.	Bromhexine	74-84	transmembrane serine protease 2	Homo sapiens	20-27
32360584-0	2020	Possible use of the mucolytic drug, bromhexine hydrochloride, as a prophylactic agent against SARS-CoV-2 infection based on its action on the Transmembrane Serine Protease 2.	Bromhexine	36-60	transmembrane serine protease 2	Homo sapiens	142-173
28444776-1	2017	The antifungal effects of ambroxol (Amb; the metabolite VIII of bromhexine) against Cryptococcus planktonic cells and mature biofilms were investigated in this study.	Bromhexine	64-74	cytochrome c oxidase subunit 8A	Homo sapiens	56-60
26171905-26	2015	Improvements in dyspnoea, wheeze and cough-free days were reported for small trials of ICS and LABA (long-acting beta2-agonsts)/ICS and cough reduction was also reported for a small bromhexine trial.	Bromhexine	182-192	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	113-118
33722999-1	2021	BACKGROUND: Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controlling influenza and parainfluenza infection; however, its efficacy in COVID-19 is controversial.	Bromhexine	12-22	transmembrane serine protease 2	Homo sapiens	48-79
32741259-7	2020	Camostat and bromhexine are known TMPRSS2 inhibitor drugs, hence these were used as control molecules throughout the study.	Bromhexine	13-23	transmembrane serine protease 2	Homo sapiens	34-41
32458206-5	2020	Using bromhexine at a dosage that selectively inhibits TMPRSS2 and, in so doing, inhibits TMPRSS2-specific viral entry is likely to be effective against SARS-CoV-2.	Bromhexine	6-16	transmembrane serine protease 2	Homo sapiens	55-62
32458206-5	2020	Using bromhexine at a dosage that selectively inhibits TMPRSS2 and, in so doing, inhibits TMPRSS2-specific viral entry is likely to be effective against SARS-CoV-2.	Bromhexine	6-16	transmembrane serine protease 2	Homo sapiens	90-97
32334052-0	2020	Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection.	Bromhexine	75-85	transmembrane serine protease 2	Homo sapiens	48-55
32651960-6	2020	Additionally, Veber analysis and molecular docking experiments of bromhexine to mouse (m) and human (h) Nav1.6-1.9 were carried out.	Bromhexine	66-76	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	104-110
32651960-11	2020	Bromhexine was predicted to be a strong inhibitor of mNav1.6, mNav1.7, mNav1.9, and hNav1.7 - hNav1.9.	Bromhexine	0-10	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	53-60
32651960-11	2020	Bromhexine was predicted to be a strong inhibitor of mNav1.6, mNav1.7, mNav1.9, and hNav1.7 - hNav1.9.	Bromhexine	0-10	sodium channel, voltage-gated, type IX, alpha	Mus musculus	62-69
32651960-11	2020	Bromhexine was predicted to be a strong inhibitor of mNav1.6, mNav1.7, mNav1.9, and hNav1.7 - hNav1.9.	Bromhexine	0-10	sodium channel, voltage-gated, type XI, alpha	Mus musculus	71-78
32651960-11	2020	Bromhexine was predicted to be a strong inhibitor of mNav1.6, mNav1.7, mNav1.9, and hNav1.7 - hNav1.9.	Bromhexine	0-10	sodium voltage-gated channel alpha subunit 9	Homo sapiens	84-91
32651960-11	2020	Bromhexine was predicted to be a strong inhibitor of mNav1.6, mNav1.7, mNav1.9, and hNav1.7 - hNav1.9.	Bromhexine	0-10	sodium voltage-gated channel alpha subunit 11	Homo sapiens	94-101
31365127-0	2020	Bromhexine elevates REP2 expression to stimulate secretion from human primary conjunctiva fornix epithelial cells.	Bromhexine	0-10	CHM like Rab escort protein	Homo sapiens	20-24
31365127-3	2020	Here, we administered bromhexine at low doses in human primary conjunctival fornix epithelial cells, and found it stimulated MUC5AC secretion and lipid droplet production.	Bromhexine	22-32	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	125-131
31365127-4	2020	Expression of the metabolism-related gene CHML was also upregulated by bromhexine treatment, and REP2, the protein produced by the CHML gene, was induced.	Bromhexine	71-81	CHM like Rab escort protein	Homo sapiens	42-46
23624039-3	2013	A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 530 nm of (Br-HCl)with PA, CLPH, AR and Rk respectively; 410, 410, 435 and 530 of (E-HCl) with PA, CLPH, AR and Rk respectively.	Bromhexine	167-173	calcium binding protein, spermatid associated 1	Homo sapiens	183-187
23624039-3	2013	A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 530 nm of (Br-HCl)with PA, CLPH, AR and Rk respectively; 410, 410, 435 and 530 of (E-HCl) with PA, CLPH, AR and Rk respectively.	Bromhexine	167-173	calcium binding protein, spermatid associated 1	Homo sapiens	255-259
20031363-3	2010	A sensitive and selective rapid resolution liquid chromatography tandem mass spectrometry (RRLC-MS/MS) method was developed to quantify the concentration of bromhexine and its two major metabolites (E-4-HDMB and E-3-HDMB) in human plasma.	Bromhexine	157-167	ubiquitination factor E4A	Homo sapiens	199-207
20031363-3	2010	A sensitive and selective rapid resolution liquid chromatography tandem mass spectrometry (RRLC-MS/MS) method was developed to quantify the concentration of bromhexine and its two major metabolites (E-4-HDMB and E-3-HDMB) in human plasma.	Bromhexine	157-167	small nucleolar RNA, H/ACA box 63	Homo sapiens	212-220