PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29899865-0	2018	Oleanolic acid induces p53-dependent apoptosis via the ERK/JNK/AKT pathway in cancer cell lines in prostatic cancer xenografts in mice.	Oleanolic Acid	0-14	transformation related protein 53, pseudogene	Mus musculus	23-26
29973206-0	2018	Oleanolic acid attenuates TGF-beta1-induced epithelial-mesenchymal transition in NRK-52E cells.	Oleanolic Acid	0-14	transforming growth factor, beta 1	Rattus norvegicus	26-35
29973206-2	2018	Oleanolic acid (OA), an activator of NF-E2-related factor 2 (Nrf2), is reported to attenuate renal fibrosis in mice with unilateral ureteral obstruction.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	37-59
29973206-2	2018	Oleanolic acid (OA), an activator of NF-E2-related factor 2 (Nrf2), is reported to attenuate renal fibrosis in mice with unilateral ureteral obstruction.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-65
29677678-1	2018	During the last decade, ursolic and oleanolic acids have been of considerable interest because of their alpha-glucosidase inhibitory activities and potential effects for treatment of type 2 diabetes.	Oleanolic Acid	36-51	sucrase-isomaltase	Homo sapiens	104-121
29677678-4	2018	The limit of detection of the method for ursolic acid and oleanolic acid were 14 ng mL-1 and 13 ng mL-1, respectively.	Oleanolic Acid	58-72	L1 cell adhesion molecule	Mus musculus	84-103
29899865-0	2018	Oleanolic acid induces p53-dependent apoptosis via the ERK/JNK/AKT pathway in cancer cell lines in prostatic cancer xenografts in mice.	Oleanolic Acid	0-14	mitogen-activated protein kinase 1	Mus musculus	55-58
29899865-0	2018	Oleanolic acid induces p53-dependent apoptosis via the ERK/JNK/AKT pathway in cancer cell lines in prostatic cancer xenografts in mice.	Oleanolic Acid	0-14	mitogen-activated protein kinase 8	Mus musculus	59-62
29899865-0	2018	Oleanolic acid induces p53-dependent apoptosis via the ERK/JNK/AKT pathway in cancer cell lines in prostatic cancer xenografts in mice.	Oleanolic Acid	0-14	thymoma viral proto-oncogene 1	Mus musculus	63-66
29805439-0	2018	The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARalpha Activation.	Oleanolic Acid	24-38	peroxisome proliferator activated receptor alpha	Mus musculus	68-77
29467861-10	2018	The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells.	Oleanolic Acid	129-143	BCL2 apoptosis regulator	Homo sapiens	26-31
29467861-10	2018	The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells.	Oleanolic Acid	129-143	BCL2 associated X, apoptosis regulator	Homo sapiens	80-83
29467861-10	2018	The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells.	Oleanolic Acid	129-143	caspase 9	Homo sapiens	219-228
29467861-10	2018	The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells.	Oleanolic Acid	129-143	caspase 3	Homo sapiens	233-242
29467861-10	2018	The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells.	Oleanolic Acid	129-143	annexin A5	Homo sapiens	263-272
29467861-10	2018	The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells.	Oleanolic Acid	169-183	BCL2 apoptosis regulator	Homo sapiens	26-31
29467861-10	2018	The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells.	Oleanolic Acid	169-183	BCL2 associated X, apoptosis regulator	Homo sapiens	80-83
29467861-10	2018	The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells.	Oleanolic Acid	169-183	caspase 9	Homo sapiens	219-228
29467861-10	2018	The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells.	Oleanolic Acid	169-183	caspase 3	Homo sapiens	233-242
29467861-10	2018	The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells.	Oleanolic Acid	169-183	annexin A5	Homo sapiens	263-272
29467861-11	2018	Furthermore, treatment of SMMC-7721 cells with the oleanolic acid derivative induced a reduction of the intracellular ATP expression level, loss of DeltaPsim and Cyt-C release from the mitochondria.	Oleanolic Acid	51-65	cytochrome c, somatic	Homo sapiens	162-167
29162643-8	2018	The structural comparison between hedragonic acid-bound FXR and oleanolic acid-bound GPBAR1 explained the molecular basis for the selectivity of oleanane-type triterpenes for FXR.	Oleanolic Acid	64-78	G protein-coupled bile acid receptor 1	Mus musculus	85-91
29030193-0	2018	Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on alpha-glucosidase.	Oleanolic Acid	51-65	sucrase-isomaltase	Homo sapiens	86-103
29030193-2	2018	This work is to investigate the kinetics and inhibition mechanism of oleanolic acid and ursolic acid on alpha-glucosidase.	Oleanolic Acid	69-83	sucrase-isomaltase	Homo sapiens	104-121
29030193-5	2018	The binding constants of oleanolic acid and ursolic acid with alpha-glucosidase at 298K were (2.04+-0.02)x103 and (1.87+-0.02)x103Lmol-1, respectively.	Oleanolic Acid	25-39	sucrase-isomaltase	Homo sapiens	62-79
29030193-6	2018	Docking results showed that oleanolic acid and ursolic acid bound in different allosteric sites of cavity 2 and cavity 4 on alpha-glucosidase, respectively, which triggered allosteric regulation to perturb conformational dynamics of alpha-glucosidase, eventually leading to a decrease of catalytic activity of the enzyme.	Oleanolic Acid	28-42	sucrase-isomaltase	Homo sapiens	124-141
29030193-6	2018	Docking results showed that oleanolic acid and ursolic acid bound in different allosteric sites of cavity 2 and cavity 4 on alpha-glucosidase, respectively, which triggered allosteric regulation to perturb conformational dynamics of alpha-glucosidase, eventually leading to a decrease of catalytic activity of the enzyme.	Oleanolic Acid	28-42	sucrase-isomaltase	Homo sapiens	233-250
29030193-8	2018	The combination of oleanolic acid and ursolic acid displayed a significant synergistic inhibition on alpha-glucosidase.	Oleanolic Acid	19-33	sucrase-isomaltase	Homo sapiens	101-118
29162643-8	2018	The structural comparison between hedragonic acid-bound FXR and oleanolic acid-bound GPBAR1 explained the molecular basis for the selectivity of oleanane-type triterpenes for FXR.	Oleanolic Acid	64-78	nuclear receptor subfamily 1, group H, member 4	Mus musculus	175-178
29065844-0	2018	Oleanolic Acid Inhibits Colorectal Cancer Angiogenesis by Blocking the VEGFR2 Signaling Pathway.	Oleanolic Acid	0-14	kinase insert domain receptor	Homo sapiens	71-77
28792088-0	2017	The anti-proliferative effects of oleanolic acid on A7r5 cells-Role of UCP2 and downstream FGF-2/p53/TSP-1.	Oleanolic Acid	34-48	uncoupling protein 2	Rattus norvegicus	71-75
30149760-2	2018	Our previous study demonstrated that oleanolic acid (OA), a natural compound found in Chinese herbs had ET-1 antagonistic effects.	Oleanolic Acid	37-51	endothelin 1	Homo sapiens	104-108
29564983-4	2018	METHODS: Terpenoids such as abietic acid, oleanolic acid, alpha-amyrin acetate, beta-amyrin acetate were docked with AchE and HDAC3 receptors using AutoDock Vina (version 1.1.2).	Oleanolic Acid	42-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	117-121
29564983-4	2018	METHODS: Terpenoids such as abietic acid, oleanolic acid, alpha-amyrin acetate, beta-amyrin acetate were docked with AchE and HDAC3 receptors using AutoDock Vina (version 1.1.2).	Oleanolic Acid	42-56	histone deacetylase 3	Homo sapiens	126-131
29793333-0	2018	Oleanolic acid protects against pathogenesis of atherosclerosis, possibly via FXR-mediated angiotensin (Ang)-(1-7) upregulation.	Oleanolic Acid	0-14	nuclear receptor subfamily 1 group H member 4	Homo sapiens	78-81
28792088-0	2017	The anti-proliferative effects of oleanolic acid on A7r5 cells-Role of UCP2 and downstream FGF-2/p53/TSP-1.	Oleanolic Acid	34-48	fibroblast growth factor 2	Rattus norvegicus	91-96
28880428-0	2017	Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.	Oleanolic Acid	29-43	AKT serine/threonine kinase 1	Homo sapiens	105-108
28880428-0	2017	Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.	Oleanolic Acid	29-43	Janus kinase 2	Homo sapiens	113-117
28880428-0	2017	Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.	Oleanolic Acid	29-43	signal transducer and activator of transcription 3	Homo sapiens	118-123
28792088-0	2017	The anti-proliferative effects of oleanolic acid on A7r5 cells-Role of UCP2 and downstream FGF-2/p53/TSP-1.	Oleanolic Acid	34-48	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	97-100
28792088-0	2017	The anti-proliferative effects of oleanolic acid on A7r5 cells-Role of UCP2 and downstream FGF-2/p53/TSP-1.	Oleanolic Acid	34-48	thrombospondin 1	Rattus norvegicus	101-106
28944913-0	2017	Oleanolic acid alleviates diabetic rat carotid artery injury through the inhibition of NLRP3 inflammasome signaling pathways.	Oleanolic Acid	0-14	NLR family, pyrin domain containing 3	Rattus norvegicus	87-92
28944913-3	2017	The present study evaluated whether oleanolic acid improved diabetic rat carotid artery injury through the inhibition of nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasomes signaling pathways.	Oleanolic Acid	36-50	NLR family, pyrin domain containing 3	Rattus norvegicus	207-212
28944913-8	2017	In addition, oleanolic acid administration significantly downregulated the mRNA and protein expression levels of endothelin 1 in diabetic rats.	Oleanolic Acid	13-27	endothelin 1	Rattus norvegicus	113-125
28944913-10	2017	Serum levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and IL-18 in the oleanolic acid-treated diabetic rats were downregulated.	Oleanolic Acid	91-105	tumor necrosis factor	Rattus norvegicus	16-43
28944913-10	2017	Serum levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and IL-18 in the oleanolic acid-treated diabetic rats were downregulated.	Oleanolic Acid	91-105	interleukin 1 beta	Rattus norvegicus	45-67
28944913-10	2017	Serum levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and IL-18 in the oleanolic acid-treated diabetic rats were downregulated.	Oleanolic Acid	91-105	interleukin 6	Rattus norvegicus	69-73
28944913-10	2017	Serum levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and IL-18 in the oleanolic acid-treated diabetic rats were downregulated.	Oleanolic Acid	91-105	interleukin 18	Rattus norvegicus	78-83
28944913-11	2017	Consistent with the serum results, it was demonstrated that oleanolic acid administration caused a significant decrease in the levels of NLRP3, caspase-1 and IL-1beta in the carotid arteries of diabetic rats.	Oleanolic Acid	60-74	NLR family, pyrin domain containing 3	Rattus norvegicus	137-142
28944913-11	2017	Consistent with the serum results, it was demonstrated that oleanolic acid administration caused a significant decrease in the levels of NLRP3, caspase-1 and IL-1beta in the carotid arteries of diabetic rats.	Oleanolic Acid	60-74	caspase 1	Rattus norvegicus	144-153
28944913-11	2017	Consistent with the serum results, it was demonstrated that oleanolic acid administration caused a significant decrease in the levels of NLRP3, caspase-1 and IL-1beta in the carotid arteries of diabetic rats.	Oleanolic Acid	60-74	interleukin 1 beta	Rattus norvegicus	158-166
28944913-12	2017	Taken together, these observations suggested that oleanolic acid attenuated carotid artery injury in diabetic rats and the underlying mechanism was mediated, at least partially, through the suppression of NLRP3 inflammasome signaling pathways.	Oleanolic Acid	50-64	NLR family, pyrin domain containing 3	Rattus norvegicus	205-210
28627773-0	2017	Oleanolic acid derivative DKS26 exerts antidiabetic and hepatoprotective effects in diabetic mice and promotes glucagon-like peptide-1 secretion and expression in intestinal cells.	Oleanolic Acid	0-14	glucagon	Mus musculus	111-134
28964635-3	2017	For alpha-glucosidase inhibition, the IC50 values of ursolic acid, corosolic acid, betulinic acid, and oleanolic acid were 12.1+-1.0muM, 17.2+-0.9muM, 14.9+-1.9muM, and 35.6+-2.6muM, respectively.	Oleanolic Acid	103-117	sucrase-isomaltase	Homo sapiens	4-21
28723343-0	2017	beta-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model.	Oleanolic Acid	28-42	catenin beta 1	Homo sapiens	0-12
29077044-7	2017	Screening assays for evaluating the anti-KLK5 activity revealed that ursolic acid, oleanolic acid, saikosaponin b1, tumulosic acid and pachymic acid suppressed the KLK5 protease activity, although critical molecular moieties contributing to anti-KLK5 activity were unclarified.	Oleanolic Acid	83-97	kallikrein related peptidase 5	Homo sapiens	41-45
29077044-7	2017	Screening assays for evaluating the anti-KLK5 activity revealed that ursolic acid, oleanolic acid, saikosaponin b1, tumulosic acid and pachymic acid suppressed the KLK5 protease activity, although critical molecular moieties contributing to anti-KLK5 activity were unclarified.	Oleanolic Acid	83-97	kallikrein related peptidase 5	Homo sapiens	164-168
29077044-7	2017	Screening assays for evaluating the anti-KLK5 activity revealed that ursolic acid, oleanolic acid, saikosaponin b1, tumulosic acid and pachymic acid suppressed the KLK5 protease activity, although critical molecular moieties contributing to anti-KLK5 activity were unclarified.	Oleanolic Acid	83-97	kallikrein related peptidase 5	Homo sapiens	164-168
28945086-0	2017	Oleanolic Acid-Mediated Inhibition of Pregnane X Receptor and Constitutive Androstane Receptor Attenuates Rifampin-Isoniazid Cytotoxicity.	Oleanolic Acid	0-14	nuclear receptor subfamily 1 group I member 2	Homo sapiens	38-57
28945086-0	2017	Oleanolic Acid-Mediated Inhibition of Pregnane X Receptor and Constitutive Androstane Receptor Attenuates Rifampin-Isoniazid Cytotoxicity.	Oleanolic Acid	0-14	nuclear receptor subfamily 1 group I member 3	Homo sapiens	62-94
28945086-3	2017	Here, we aimed to determine the antagonistic effect of oleanolic acid (OA) on PXR and CAR.	Oleanolic Acid	55-69	nuclear receptor subfamily 1 group I member 2	Homo sapiens	78-81
28945086-3	2017	Here, we aimed to determine the antagonistic effect of oleanolic acid (OA) on PXR and CAR.	Oleanolic Acid	55-69	nuclear receptor subfamily 1 group I member 3	Homo sapiens	86-89
28945086-3	2017	Here, we aimed to determine the antagonistic effect of oleanolic acid (OA) on PXR and CAR.	Oleanolic Acid	71-73	nuclear receptor subfamily 1 group I member 2	Homo sapiens	78-81
28945086-3	2017	Here, we aimed to determine the antagonistic effect of oleanolic acid (OA) on PXR and CAR.	Oleanolic Acid	71-73	nuclear receptor subfamily 1 group I member 3	Homo sapiens	86-89
28627773-2	2017	This study was designed to investigate antidiabetic and hepatoprotective effects of a novel oleanolic acid derivative DKS26 in diabetic mice and elucidate its underlying GLP-1 related antidiabetic mechanisms in vitro and in vivo.	Oleanolic Acid	92-106	glucagon	Mus musculus	170-175
28647370-0	2017	Oleanolic acid prevents cartilage degeneration in diabetic mice via PPARgamma associated mitochondrial stabilization.	Oleanolic Acid	0-14	peroxisome proliferator activated receptor gamma	Mus musculus	68-77
27600106-0	2017	In vitro inhibition of UGT1A3, UGT1A4 by ursolic acid and oleanolic acid and drug-drug interaction risk prediction.	Oleanolic Acid	58-72	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	23-29
27600106-0	2017	In vitro inhibition of UGT1A3, UGT1A4 by ursolic acid and oleanolic acid and drug-drug interaction risk prediction.	Oleanolic Acid	58-72	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	31-37
28647370-5	2017	OLA prevented the high glucose induced cell injury and decreased the level of MMP-13, PGE2 and IL-6 due to decreasing mitochondrial membrane potential and stimulated the ATP production.	Oleanolic Acid	0-3	interleukin 6	Mus musculus	95-99
28647370-7	2017	And the reversed SOD2 expression and activity may be ascribed to decreased SOD2 protein degradation by OLA treatment, via PPPAgamma.	Oleanolic Acid	103-106	superoxide dismutase 2, mitochondrial	Mus musculus	17-21
28514645-0	2017	Oleanolic acid modulates the renin-angiotensin system and cardiac natriuretic hormone concomitantly with volume and pressure balance in rats.	Oleanolic Acid	0-14	renin	Rattus norvegicus	29-34
28647370-7	2017	And the reversed SOD2 expression and activity may be ascribed to decreased SOD2 protein degradation by OLA treatment, via PPPAgamma.	Oleanolic Acid	103-106	superoxide dismutase 2, mitochondrial	Mus musculus	75-79
28647370-8	2017	In conclusion, OLA protected against the high-glucose-induced cartilage injury via PPARgamma/SOD2 pathway.	Oleanolic Acid	15-18	peroxisome proliferator activated receptor gamma	Mus musculus	83-92
28647370-8	2017	In conclusion, OLA protected against the high-glucose-induced cartilage injury via PPARgamma/SOD2 pathway.	Oleanolic Acid	15-18	superoxide dismutase 2, mitochondrial	Mus musculus	93-97
28514645-6	2017	Here, we found that oleanolic acid suppressed plasma levels of renin activity and aldosterone and intrarenal levels of renin and angiotensin II type 1 receptor expression and increased angiotensin II type 2 receptor in normotensive and hypertensive rats.	Oleanolic Acid	20-34	renin	Rattus norvegicus	63-68
28514645-6	2017	Here, we found that oleanolic acid suppressed plasma levels of renin activity and aldosterone and intrarenal levels of renin and angiotensin II type 1 receptor expression and increased angiotensin II type 2 receptor in normotensive and hypertensive rats.	Oleanolic Acid	20-34	ATPase H+ transporting accessory protein 2	Rattus norvegicus	119-159
28514645-6	2017	Here, we found that oleanolic acid suppressed plasma levels of renin activity and aldosterone and intrarenal levels of renin and angiotensin II type 1 receptor expression and increased angiotensin II type 2 receptor in normotensive and hypertensive rats.	Oleanolic Acid	20-34	angiotensin II receptor, type 2	Rattus norvegicus	185-215
28514645-8	2017	Further, oleanolic acid suppressed angiotensin II type 1 receptor and natriuretic peptide receptor-C expression and increased angiotensin II type 2 receptor and ANP expression in the heart and aorta.	Oleanolic Acid	9-23	angiotensin II receptor, type 1b	Rattus norvegicus	35-65
28514645-8	2017	Further, oleanolic acid suppressed angiotensin II type 1 receptor and natriuretic peptide receptor-C expression and increased angiotensin II type 2 receptor and ANP expression in the heart and aorta.	Oleanolic Acid	9-23	angiotensin II receptor, type 2	Rattus norvegicus	126-156
28514645-10	2017	These findings suggest that beneficial effects of oleanolic acid on the cardiorenal system are closely associated with its roles on the renin-angiotensin system and cardiac natriuretic hormone system.	Oleanolic Acid	50-64	renin	Rattus norvegicus	136-141
28978086-0	2017	AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells.	Oleanolic Acid	48-62	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	0-4
28681592-0	2017	Oleanolic Acid Promotes Neuronal Differentiation and Histone Deacetylase 5 Phosphorylation in Rat Hippocampal Neurons.	Oleanolic Acid	0-14	histone deacetylase 5	Rattus norvegicus	53-74
28766112-0	2017	Oleanolic acid and ursolic acid as potential inhibitors of human salivary alpha-amylase: insights from in vitro assays and in silico simulations.	Oleanolic Acid	0-14	amylase alpha 1A	Homo sapiens	65-87
28766112-4	2017	Our in vitro inhibition studies demonstrated that oleanolic acid and ursolic acid non-competitively inhibit the activity and function of human salivary alpha-amylase.	Oleanolic Acid	50-64	amylase alpha 1A	Homo sapiens	143-165
28766112-5	2017	The molecular simulations revealed that oleanolic acid and ursolic acid interact with amino acid residues within the binding pocket of human salivary alpha-amylase, among which the side chain of Arg195 and Asp 197 was supposed to be important in imparting the inhibitory activity of triterpenoids.	Oleanolic Acid	40-54	amylase alpha 1A	Homo sapiens	141-163
28350071-0	2017	Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF-kappaB pathway in silicotic rats.	Oleanolic Acid	22-36	AKT serine/threonine kinase 1	Rattus norvegicus	109-112
28673009-0	2017	Oleanolic acid protects against diabetic cardiomyopathy via modulation of the nuclear factor erythroid 2 and insulin signaling pathways.	Oleanolic Acid	0-14	nuclear factor, erythroid 2	Rattus norvegicus	78-104
28673009-5	2017	The results demonstrated that OL significantly reversed the DCM-induced changes to body weight, heart rate, echocardiography and hemodynamics, phosphorylated-glycogen synthase (GS) and glycogen phosphorylase (GP) activity in diabetic rats (all P<0.01).	Oleanolic Acid	30-32	glycogen phosphorylase L	Rattus norvegicus	185-207
28673009-5	2017	The results demonstrated that OL significantly reversed the DCM-induced changes to body weight, heart rate, echocardiography and hemodynamics, phosphorylated-glycogen synthase (GS) and glycogen phosphorylase (GP) activity in diabetic rats (all P<0.01).	Oleanolic Acid	30-32	glycogen phosphorylase L	Rattus norvegicus	209-211
28673009-6	2017	Treatment of diabetic rats with OL significantly inhibited oxidative stress and activated heme oxygenase (HO)-1/nuclear factor erythroid 2 (Nrf2) signaling in a rat model of diabetes (both P<0.01).	Oleanolic Acid	32-34	nuclear factor, erythroid 2	Rattus norvegicus	112-138
28673009-6	2017	Treatment of diabetic rats with OL significantly inhibited oxidative stress and activated heme oxygenase (HO)-1/nuclear factor erythroid 2 (Nrf2) signaling in a rat model of diabetes (both P<0.01).	Oleanolic Acid	32-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144
28673009-7	2017	The results of the present study indicate that OL protects against DCM through the HO-1/Nrf2 and insulin modulating GS/GP signaling pathways.	Oleanolic Acid	47-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	88-92
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	Oleanolic Acid	58-72	carboxylesterase 1	Homo sapiens	146-150
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	Oleanolic Acid	58-72	carboxylesterase 2	Homo sapiens	186-190
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	Oleanolic Acid	74-76	carboxylesterase 1	Homo sapiens	146-150
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	Oleanolic Acid	74-76	carboxylesterase 2	Homo sapiens	186-190
28351683-5	2017	Acid hydrolysis of both compounds yielded oleanolic acid (3) which was non or least toxic to human peripheral blood mono nuclear cells (Selectivity index = >10) while retaining similar macrofilaricidal (IC50 = 38.4 muM) and microfilaricidal (IC50 = 35.6 muM) activities.	Oleanolic Acid	42-56	latexin	Homo sapiens	218-221
28351683-5	2017	Acid hydrolysis of both compounds yielded oleanolic acid (3) which was non or least toxic to human peripheral blood mono nuclear cells (Selectivity index = >10) while retaining similar macrofilaricidal (IC50 = 38.4 muM) and microfilaricidal (IC50 = 35.6 muM) activities.	Oleanolic Acid	42-56	latexin	Homo sapiens	257-260
28351683-6	2017	In adult female worms treated with 50 and 100 muM doses of oleanolic acid, condensation of nuclear DNA, apoptotic body formation and tissue damage was observed by using Hoechst 33342 staining, TUNEL assay and Hematoxylin and Eosin staining respectively.	Oleanolic Acid	59-73	latexin	Homo sapiens	46-49
27903618-0	2017	Hypolipidemic effect of oleanolic acid is mediated by the miR-98-5p/PGC-1beta axis in high-fat diet-induced hyperlipidemic mice.	Oleanolic Acid	24-38	microRNA 98	Mus musculus	58-64
28533680-0	2017	Preparation, characterization, and in vitro/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles.	Oleanolic Acid	60-74	lactotransferrin	Rattus norvegicus	82-93
28272302-0	2017	A New Oleanolic Acid Derivative against CCl4-Induced Hepatic Fibrosis in Rats.	Oleanolic Acid	6-20	C-C motif chemokine ligand 4	Rattus norvegicus	40-44
28445411-1	2017	The pentacyclic triterpene oleanolic acid (OA, 1) with known farnesoid X receptor (FXR) modulatory activity was modified at its C-3 position to find new FXR-interacting agents.	Oleanolic Acid	27-41	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	71-81
28445411-1	2017	The pentacyclic triterpene oleanolic acid (OA, 1) with known farnesoid X receptor (FXR) modulatory activity was modified at its C-3 position to find new FXR-interacting agents.	Oleanolic Acid	27-41	nuclear receptor subfamily 1 group H member 4	Homo sapiens	83-86
28445411-1	2017	The pentacyclic triterpene oleanolic acid (OA, 1) with known farnesoid X receptor (FXR) modulatory activity was modified at its C-3 position to find new FXR-interacting agents.	Oleanolic Acid	27-41	nuclear receptor subfamily 1 group H member 4	Homo sapiens	153-156
27903618-0	2017	Hypolipidemic effect of oleanolic acid is mediated by the miR-98-5p/PGC-1beta axis in high-fat diet-induced hyperlipidemic mice.	Oleanolic Acid	24-38	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Mus musculus	68-77
27903618-8	2017	Collectively, our data demonstrated that OA ameliorated hyperlipidemia, likely via regulation of the miR-98-5p/PGC-1beta axis.-Chen, S., Wen, X., Zhang, W., Wang, C., Liu, J., Liu, C. Hypolipidemic effect of oleanolic acid is mediated by the miR-98-5p/PGC-1beta axis in high-fat diet-induced hyperlipidemic mice.	Oleanolic Acid	208-222	microRNA 98	Mus musculus	101-107
28280413-0	2017	Effect of oleanolic acid on the activity, secretion and gene expression of matrix metalloproteinase-3 in articular chondrocytes in vitro and the production of matrix metalloproteinase-3 in vivo.	Oleanolic Acid	10-24	stromelysin-1	Oryctolagus cuniculus	75-101
28280413-1	2017	In the present study, we tried to examine whether oleanolic acid regulates the activity, secretion and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as the production of MMP-3 in the knee joint of rat to evaluate the potential chondroprotective effect of oleanolic acid.	Oleanolic Acid	50-64	stromelysin-1	Oryctolagus cuniculus	122-148
28280413-6	2017	These results suggest that oleanolic acid can regulate the activity, secretion and gene expression of MMP-3, by directly acting on articular chondrocytes.	Oleanolic Acid	27-41	stromelysin-1	Oryctolagus cuniculus	102-107
28280413-1	2017	In the present study, we tried to examine whether oleanolic acid regulates the activity, secretion and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as the production of MMP-3 in the knee joint of rat to evaluate the potential chondroprotective effect of oleanolic acid.	Oleanolic Acid	50-64	stromelysin-1	Oryctolagus cuniculus	150-155
28280413-1	2017	In the present study, we tried to examine whether oleanolic acid regulates the activity, secretion and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as the production of MMP-3 in the knee joint of rat to evaluate the potential chondroprotective effect of oleanolic acid.	Oleanolic Acid	50-64	stromelysin-1	Oryctolagus cuniculus	237-242
28280413-3	2017	In rabbit articular chondrocytes, the effects of oleanolic acid on IL-1beta-induced secretion and proteolytic activity of MMP-3 were investigated using western blot analysis and casein zymography, respectively.	Oleanolic Acid	49-63	interleukin-1 beta	Oryctolagus cuniculus	67-75
28280413-3	2017	In rabbit articular chondrocytes, the effects of oleanolic acid on IL-1beta-induced secretion and proteolytic activity of MMP-3 were investigated using western blot analysis and casein zymography, respectively.	Oleanolic Acid	49-63	stromelysin-1	Oryctolagus cuniculus	122-127
28280413-4	2017	The effect of oleanolic acid on in vivo MMP-3 protein production was also examined, after intra-articular injection to the knee joint of rat.	Oleanolic Acid	14-28	matrix metallopeptidase 3	Rattus norvegicus	40-45
28280413-5	2017	The results were as follows: (1) oleanolic acid inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) oleanolic acid reduced the secretion and proteolytic activity of MMP-3; (3) oleanolic acid suppressed the production of MMP-3 protein in vivo.	Oleanolic Acid	33-47	stromelysin-1	Oryctolagus cuniculus	81-86
28280413-5	2017	The results were as follows: (1) oleanolic acid inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) oleanolic acid reduced the secretion and proteolytic activity of MMP-3; (3) oleanolic acid suppressed the production of MMP-3 protein in vivo.	Oleanolic Acid	33-47	interstitial collagenase	Oryctolagus cuniculus	88-93
28280413-5	2017	The results were as follows: (1) oleanolic acid inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) oleanolic acid reduced the secretion and proteolytic activity of MMP-3; (3) oleanolic acid suppressed the production of MMP-3 protein in vivo.	Oleanolic Acid	33-47	collagenase 3	Oryctolagus cuniculus	95-101
28280413-5	2017	The results were as follows: (1) oleanolic acid inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) oleanolic acid reduced the secretion and proteolytic activity of MMP-3; (3) oleanolic acid suppressed the production of MMP-3 protein in vivo.	Oleanolic Acid	33-47	A disintegrin and metalloproteinase with thrombospondin motifs 4	Oryctolagus cuniculus	103-111
28280413-5	2017	The results were as follows: (1) oleanolic acid inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) oleanolic acid reduced the secretion and proteolytic activity of MMP-3; (3) oleanolic acid suppressed the production of MMP-3 protein in vivo.	Oleanolic Acid	33-47	LOW QUALITY PROTEIN: A disintegrin and metalloproteinase with thrombospondin motifs 5	Oryctolagus cuniculus	117-125
28280413-5	2017	The results were as follows: (1) oleanolic acid inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) oleanolic acid reduced the secretion and proteolytic activity of MMP-3; (3) oleanolic acid suppressed the production of MMP-3 protein in vivo.	Oleanolic Acid	33-47	stromelysin-1	Oryctolagus cuniculus	251-256
28280413-5	2017	The results were as follows: (1) oleanolic acid inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) oleanolic acid reduced the secretion and proteolytic activity of MMP-3; (3) oleanolic acid suppressed the production of MMP-3 protein in vivo.	Oleanolic Acid	33-47	stromelysin-1	Oryctolagus cuniculus	251-256
27776314-1	2017	The binding properties of pentacyclic triterpenoid isomeric drugs, i.e. ursolic acid (UA) and oleanolic acid (OA), to bovine lactoferrin (BLF) have been studied by molecule modeling, fluorescence spectroscopy, UV-visible absorbance spectroscopy and infrared spectroscopy (IR).	Oleanolic Acid	94-108	lactotransferrin	Bos taurus	125-136
27776314-1	2017	The binding properties of pentacyclic triterpenoid isomeric drugs, i.e. ursolic acid (UA) and oleanolic acid (OA), to bovine lactoferrin (BLF) have been studied by molecule modeling, fluorescence spectroscopy, UV-visible absorbance spectroscopy and infrared spectroscopy (IR).	Oleanolic Acid	110-112	lactotransferrin	Bos taurus	125-136
27470063-7	2017	Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.	Oleanolic Acid	35-49	brain derived neurotrophic factor	Mus musculus	118-122
27935635-0	2017	Oleanolic acid rejuvenates testicular function through attenuating germ cell DNA damage and apoptosis via deactivation of NF-kappaB, p53 and p38 signalling pathways.	Oleanolic Acid	0-14	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	133-136
27935635-0	2017	Oleanolic acid rejuvenates testicular function through attenuating germ cell DNA damage and apoptosis via deactivation of NF-kappaB, p53 and p38 signalling pathways.	Oleanolic Acid	0-14	mitogen activated protein kinase 14	Rattus norvegicus	141-144
27935635-15	2017	CONCLUSIONS: Oleanolic acid effectively rejuvenates testicular function via attenuating germ cell DNA damage and apoptosis through deactivation of NF-kappaB, p53 and p38 signalling pathways.	Oleanolic Acid	13-27	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	158-161
27935635-15	2017	CONCLUSIONS: Oleanolic acid effectively rejuvenates testicular function via attenuating germ cell DNA damage and apoptosis through deactivation of NF-kappaB, p53 and p38 signalling pathways.	Oleanolic Acid	13-27	mitogen activated protein kinase 14	Rattus norvegicus	166-169
27470063-0	2017	Oleanolic acid ameliorates cognitive dysfunction caused by cholinergic blockade via TrkB-dependent BDNF signaling.	Oleanolic Acid	0-14	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	84-88
27470063-0	2017	Oleanolic acid ameliorates cognitive dysfunction caused by cholinergic blockade via TrkB-dependent BDNF signaling.	Oleanolic Acid	0-14	brain derived neurotrophic factor	Mus musculus	99-103
27470063-7	2017	Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.	Oleanolic Acid	35-49	mitogen-activated protein kinase 3	Mus musculus	123-129
27470063-4	2017	In accordance with previous reports, oleanolic acid enhanced extracellular-signal-regulated kinase 1/2 (ERK1/2) and cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the hippocampus.	Oleanolic Acid	37-51	mitogen-activated protein kinase 3	Mus musculus	61-102
27470063-7	2017	Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.	Oleanolic Acid	35-49	cAMP responsive element binding protein 1	Mus musculus	130-134
27470063-4	2017	In accordance with previous reports, oleanolic acid enhanced extracellular-signal-regulated kinase 1/2 (ERK1/2) and cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the hippocampus.	Oleanolic Acid	37-51	mitogen-activated protein kinase 3	Mus musculus	104-110
27470063-7	2017	Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.	Oleanolic Acid	35-49	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	151-155
27470063-4	2017	In accordance with previous reports, oleanolic acid enhanced extracellular-signal-regulated kinase 1/2 (ERK1/2) and cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the hippocampus.	Oleanolic Acid	37-51	cAMP responsive element binding protein 1	Mus musculus	116-153
27470063-4	2017	In accordance with previous reports, oleanolic acid enhanced extracellular-signal-regulated kinase 1/2 (ERK1/2) and cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the hippocampus.	Oleanolic Acid	37-51	cAMP responsive element binding protein 1	Mus musculus	155-159
27470063-7	2017	Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.	Oleanolic Acid	192-206	brain derived neurotrophic factor	Mus musculus	118-122
27470063-4	2017	In accordance with previous reports, oleanolic acid enhanced extracellular-signal-regulated kinase 1/2 (ERK1/2) and cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the hippocampus.	Oleanolic Acid	37-51	brain derived neurotrophic factor	Mus musculus	216-220
27470063-7	2017	Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.	Oleanolic Acid	192-206	mitogen-activated protein kinase 3	Mus musculus	123-129
27470063-5	2017	Interestingly, ameliorating effect of oleanolic acid on scopolamine-induced memory impairment was abolished by N2-(2-{[(2-oxoazepan-3-yl)amino]carbonyl}phenyl)benzo[b]thiophene-2-carboxamide (ANA-12), a potent and specific inhibitor of tropomyosin receptor kinase B (TrkB), in the passive avoidance task.	Oleanolic Acid	38-52	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	236-265
27470063-5	2017	Interestingly, ameliorating effect of oleanolic acid on scopolamine-induced memory impairment was abolished by N2-(2-{[(2-oxoazepan-3-yl)amino]carbonyl}phenyl)benzo[b]thiophene-2-carboxamide (ANA-12), a potent and specific inhibitor of tropomyosin receptor kinase B (TrkB), in the passive avoidance task.	Oleanolic Acid	38-52	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	267-271
27470063-7	2017	Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.	Oleanolic Acid	192-206	cAMP responsive element binding protein 1	Mus musculus	130-134
28067284-0	2017	Oleanolic acid ameliorates high glucose-induced endothelial dysfunction via PPARdelta activation.	Oleanolic Acid	0-14	peroxisome proliferator activated receptor delta	Homo sapiens	76-85
27750148-3	2017	Alignment of the docking conformations of oleanolic acid (OA), ursolic acid (UA) and the crystal conformations of known CETP inhibitor Torcetrapib in the active site proposed the applicability of fragment-based drug design (FBDD) approaches in this study.	Oleanolic Acid	42-56	cholesteryl ester transfer protein	Homo sapiens	120-124
27938946-0	2017	NOX2-ROS-HIF-1alpha signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation.	Oleanolic Acid	71-85	cytochrome b-245 beta chain	Homo sapiens	0-4
27517171-7	2017	Accordingly, anti-oxidants (pomegranate polyphenols), inhibition of p38 MAPK (by SB202190) or DGAT1 (by oleanolic acid), all significantly attenuated SO or LA-induced macrophage triglyceride accumulation.	Oleanolic Acid	104-118	diacylglycerol O-acyltransferase 1	Mus musculus	94-99
27938946-0	2017	NOX2-ROS-HIF-1alpha signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation.	Oleanolic Acid	71-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	Oleanolic Acid	80-94	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	148-153
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	Oleanolic Acid	80-94	acid phosphatase 5, tartrate resistant	Mus musculus	162-197
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	Oleanolic Acid	80-94	acid phosphatase 5, tartrate resistant	Mus musculus	199-203
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	Oleanolic Acid	96-98	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	148-153
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	Oleanolic Acid	96-98	acid phosphatase 5, tartrate resistant	Mus musculus	162-197
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	Oleanolic Acid	96-98	acid phosphatase 5, tartrate resistant	Mus musculus	199-203
29908114-0	2016	[Inhibitory effect of oleanolic acid on inflammatory response in IL-1beta-stimulated human synovial sarcoma SW982 cells].	Oleanolic Acid	22-36	interleukin 1 beta	Homo sapiens	65-73
27900030-0	2016	Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression.	Oleanolic Acid	0-14	tumor protein p53 pathway corepressor 1	Homo sapiens	82-93
29441916-5	2016	Treatment of SMMC-7721 cells with oleanolic acid derivatives led to the downregulation of the mRNA and protein levels of beta-catenin, c-myc, and cyclin D1.	Oleanolic Acid	34-48	catenin beta 1	Homo sapiens	121-133
27437776-0	2016	YAP and 14-3-3gamma are involved in HS-OA-induced growth inhibition of hepatocellular carcinoma cells: A novel mechanism for hydrogen sulfide releasing oleanolic acid.	Oleanolic Acid	152-166	Yes1 associated transcriptional regulator	Homo sapiens	0-19
29441916-0	2016	Oleanolic acid derivatives inhibit the Wnt/beta-catenin signaling pathway by promoting the phosphorylation of beta-catenin in human SMMC-7721 cells.	Oleanolic Acid	0-14	catenin beta 1	Homo sapiens	43-55
29441916-0	2016	Oleanolic acid derivatives inhibit the Wnt/beta-catenin signaling pathway by promoting the phosphorylation of beta-catenin in human SMMC-7721 cells.	Oleanolic Acid	0-14	catenin beta 1	Homo sapiens	110-122
29441916-3	2016	In this study, we explored the effect of oleanolic acid derivatives on the Wnt/beta-catenin signaling pathway in human hepatocellular carcinoma SMMC-7721 cells.	Oleanolic Acid	41-55	catenin beta 1	Homo sapiens	79-91
29908114-3	2016	Results showed that different concentrations of oleanolic acid(<=40 mumol L(-1)) were almost non-toxicity to SW982 cells; oleanolic acid significantly inhibited the expression of inflammatory factors in a dose-dependent manner; oleanolic acid restrained extracellular signal-related kinase (ERK), p38, c-jun N-terminal kinase (JNK) and Akt protein phosphorylation and IkappaB-alpha protein degradation obviously.	Oleanolic Acid	48-62	mitogen-activated protein kinase 1	Homo sapiens	257-292
29908114-3	2016	Results showed that different concentrations of oleanolic acid(<=40 mumol L(-1)) were almost non-toxicity to SW982 cells; oleanolic acid significantly inhibited the expression of inflammatory factors in a dose-dependent manner; oleanolic acid restrained extracellular signal-related kinase (ERK), p38, c-jun N-terminal kinase (JNK) and Akt protein phosphorylation and IkappaB-alpha protein degradation obviously.	Oleanolic Acid	48-62	mitogen-activated protein kinase 1	Homo sapiens	294-297
29908114-3	2016	Results showed that different concentrations of oleanolic acid(<=40 mumol L(-1)) were almost non-toxicity to SW982 cells; oleanolic acid significantly inhibited the expression of inflammatory factors in a dose-dependent manner; oleanolic acid restrained extracellular signal-related kinase (ERK), p38, c-jun N-terminal kinase (JNK) and Akt protein phosphorylation and IkappaB-alpha protein degradation obviously.	Oleanolic Acid	48-62	mitogen-activated protein kinase 14	Homo sapiens	300-303
29908114-3	2016	Results showed that different concentrations of oleanolic acid(<=40 mumol L(-1)) were almost non-toxicity to SW982 cells; oleanolic acid significantly inhibited the expression of inflammatory factors in a dose-dependent manner; oleanolic acid restrained extracellular signal-related kinase (ERK), p38, c-jun N-terminal kinase (JNK) and Akt protein phosphorylation and IkappaB-alpha protein degradation obviously.	Oleanolic Acid	48-62	AKT serine/threonine kinase 1	Homo sapiens	339-342
29908114-3	2016	Results showed that different concentrations of oleanolic acid(<=40 mumol L(-1)) were almost non-toxicity to SW982 cells; oleanolic acid significantly inhibited the expression of inflammatory factors in a dose-dependent manner; oleanolic acid restrained extracellular signal-related kinase (ERK), p38, c-jun N-terminal kinase (JNK) and Akt protein phosphorylation and IkappaB-alpha protein degradation obviously.	Oleanolic Acid	48-62	NFKB inhibitor alpha	Homo sapiens	371-384
29908114-4	2016	The inhibition effect of oleanolic acid on inflammatory factors stimulated by IL-1beta may be worked through MAPK, PI3K/Akt and NF-kappaB signaling pathways.	Oleanolic Acid	25-39	interleukin 1 beta	Homo sapiens	78-86
29908114-4	2016	The inhibition effect of oleanolic acid on inflammatory factors stimulated by IL-1beta may be worked through MAPK, PI3K/Akt and NF-kappaB signaling pathways.	Oleanolic Acid	25-39	mitogen-activated protein kinase 1	Homo sapiens	109-113
29908114-4	2016	The inhibition effect of oleanolic acid on inflammatory factors stimulated by IL-1beta may be worked through MAPK, PI3K/Akt and NF-kappaB signaling pathways.	Oleanolic Acid	25-39	AKT serine/threonine kinase 1	Homo sapiens	120-123
29908114-4	2016	The inhibition effect of oleanolic acid on inflammatory factors stimulated by IL-1beta may be worked through MAPK, PI3K/Akt and NF-kappaB signaling pathways.	Oleanolic Acid	25-39	nuclear factor kappa B subunit 1	Homo sapiens	128-137
27733322-0	2016	Oleanolic acid attenuates liver ischemia reperfusion injury by HO-1/Sesn2 signaling pathway.	Oleanolic Acid	0-14	heme oxygenase 1	Mus musculus	63-67
27733322-0	2016	Oleanolic acid attenuates liver ischemia reperfusion injury by HO-1/Sesn2 signaling pathway.	Oleanolic Acid	0-14	sestrin 2	Mus musculus	68-73
27409173-6	2016	Exposure of MKN45 cells to GPBAR1 ligands, TLCA, oleanolic acid or 6-ECDCA (a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells).	Oleanolic Acid	49-63	G protein-coupled bile acid receptor 1	Homo sapiens	27-33
27409173-6	2016	Exposure of MKN45 cells to GPBAR1 ligands, TLCA, oleanolic acid or 6-ECDCA (a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells).	Oleanolic Acid	49-63	nuclear receptor subfamily 1 group H member 4	Homo sapiens	83-86
27409173-6	2016	Exposure of MKN45 cells to GPBAR1 ligands, TLCA, oleanolic acid or 6-ECDCA (a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells).	Oleanolic Acid	49-63	G protein-coupled bile acid receptor 1	Homo sapiens	91-97
27409173-6	2016	Exposure of MKN45 cells to GPBAR1 ligands, TLCA, oleanolic acid or 6-ECDCA (a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells).	Oleanolic Acid	49-63	HRas proto-oncogene, GTPase	Homo sapiens	178-182
27409173-6	2016	Exposure of MKN45 cells to GPBAR1 ligands, TLCA, oleanolic acid or 6-ECDCA (a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells).	Oleanolic Acid	49-63	matrix metallopeptidase 10	Homo sapiens	190-195
27409173-6	2016	Exposure of MKN45 cells to GPBAR1 ligands, TLCA, oleanolic acid or 6-ECDCA (a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells).	Oleanolic Acid	49-63	matrix metallopeptidase 13	Homo sapiens	200-205
27409173-6	2016	Exposure of MKN45 cells to GPBAR1 ligands, TLCA, oleanolic acid or 6-ECDCA (a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells).	Oleanolic Acid	49-63	CD44 molecule (Indian blood group)	Homo sapiens	242-246
27409173-6	2016	Exposure of MKN45 cells to GPBAR1 ligands, TLCA, oleanolic acid or 6-ECDCA (a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells).	Oleanolic Acid	49-63	FAT atypical cadherin 1	Homo sapiens	251-255
27417252-7	2016	Intriguingly, overexpression of AKR1B10 in the cells resulted in a decrease in PPARgamma expression, which was recovered by addition of an AKR1B10 inhibitor oleanolic acid, inferring that PPARgamma is a downstream target of AKR1B10-dependent mechanism underlying the CDDP resistance.	Oleanolic Acid	157-171	aldo-keto reductase family 1 member B10	Homo sapiens	32-39
27417252-7	2016	Intriguingly, overexpression of AKR1B10 in the cells resulted in a decrease in PPARgamma expression, which was recovered by addition of an AKR1B10 inhibitor oleanolic acid, inferring that PPARgamma is a downstream target of AKR1B10-dependent mechanism underlying the CDDP resistance.	Oleanolic Acid	157-171	peroxisome proliferator activated receptor gamma	Homo sapiens	79-88
27417252-7	2016	Intriguingly, overexpression of AKR1B10 in the cells resulted in a decrease in PPARgamma expression, which was recovered by addition of an AKR1B10 inhibitor oleanolic acid, inferring that PPARgamma is a downstream target of AKR1B10-dependent mechanism underlying the CDDP resistance.	Oleanolic Acid	157-171	aldo-keto reductase family 1 member B10	Homo sapiens	139-146
27417252-7	2016	Intriguingly, overexpression of AKR1B10 in the cells resulted in a decrease in PPARgamma expression, which was recovered by addition of an AKR1B10 inhibitor oleanolic acid, inferring that PPARgamma is a downstream target of AKR1B10-dependent mechanism underlying the CDDP resistance.	Oleanolic Acid	157-171	peroxisome proliferator activated receptor gamma	Homo sapiens	188-197
27417252-7	2016	Intriguingly, overexpression of AKR1B10 in the cells resulted in a decrease in PPARgamma expression, which was recovered by addition of an AKR1B10 inhibitor oleanolic acid, inferring that PPARgamma is a downstream target of AKR1B10-dependent mechanism underlying the CDDP resistance.	Oleanolic Acid	157-171	aldo-keto reductase family 1 member B10	Homo sapiens	139-146
29441916-5	2016	Treatment of SMMC-7721 cells with oleanolic acid derivatives led to the downregulation of the mRNA and protein levels of beta-catenin, c-myc, and cyclin D1.	Oleanolic Acid	34-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	135-140
29441916-5	2016	Treatment of SMMC-7721 cells with oleanolic acid derivatives led to the downregulation of the mRNA and protein levels of beta-catenin, c-myc, and cyclin D1.	Oleanolic Acid	34-48	cyclin D1	Homo sapiens	146-155
29441916-6	2016	Treatment with oleanolic acid derivatives decreased the levels of beta-catenin in both the cytoplasm and the nucleus.	Oleanolic Acid	15-29	catenin beta 1	Homo sapiens	66-78
29441916-7	2016	Moreover, oleanolic acid derivatives promoted the phosphorylation of beta-catenin (Ser33/37/Thr41) in the cytoplasm.	Oleanolic Acid	10-24	catenin beta 1	Homo sapiens	69-81
29441916-8	2016	Our results suggest that oleanolic acid derivatives inhibit the Wnt/beta-catenin signaling pathway by stimulating the phosphorylation of beta-catenin (Ser33/37/Thr41) in human SMMC-7721 cells.	Oleanolic Acid	25-39	catenin beta 1	Homo sapiens	68-80
29441916-8	2016	Our results suggest that oleanolic acid derivatives inhibit the Wnt/beta-catenin signaling pathway by stimulating the phosphorylation of beta-catenin (Ser33/37/Thr41) in human SMMC-7721 cells.	Oleanolic Acid	25-39	catenin beta 1	Homo sapiens	137-149
27108756-0	2016	Oleanolic acid inhibits colorectal cancer angiogenesis in vivo and in vitro via suppression of STAT3 and Hedgehog pathways.	Oleanolic Acid	0-14	signal transducer and activator of transcription 3	Homo sapiens	95-100
27161160-4	2016	The extract was identified to inhibit ADP-induced platelet activation due to its erythrodiol content and TRAP-induced platelet activation due to the activity of uvaol and oleanolic acid.	Oleanolic Acid	171-185	TRAP	Homo sapiens	105-109
27017606-12	2016	An in vitro isotope tracing experiment showed that COT and its bioactive ingredients, such as celastrol, ursolic acid, oleanolic acid, and quercetin, significantly increased the efflux of (3)H-cholesterol.	Oleanolic Acid	119-133	mitogen-activated protein kinase kinase kinase 8	Mus musculus	51-54
26687646-0	2016	Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	119-122
26771154-0	2016	Cytoprotective Effects of Oleanolic Acid in Human Umbilical Vascular Endothelial Cells is Mediated Via UCP2/ROS/Cytochrome C/AIF Pathway.	Oleanolic Acid	26-40	uncoupling protein 2	Homo sapiens	103-107
27162477-0	2016	Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mTOR and ROS-dependent pathway.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	88-91
27162477-0	2016	Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mTOR and ROS-dependent pathway.	Oleanolic Acid	0-14	mechanistic target of rapamycin kinase	Homo sapiens	92-96
25649126-11	2016	Although 3,4-dihydroxybenzaldehyde, baicalin and ginsenoside Rb1 as HST components increased S100A8/S100A9 expression, oleanolic acid and berberine decreased their expression.	Oleanolic Acid	119-133	RB transcriptional corepressor 1	Homo sapiens	61-64
26715278-0	2016	ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway.	Oleanolic Acid	42-56	mitogen-activated protein kinase 1	Homo sapiens	0-3
26715278-0	2016	ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway.	Oleanolic Acid	42-56	mitogen-activated protein kinase 1	Homo sapiens	83-86
26715278-0	2016	ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway.	Oleanolic Acid	42-56	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
27018970-0	2016	Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4.	Oleanolic Acid	63-77	C-C motif chemokine ligand 4	Rattus norvegicus	151-155
26771154-0	2016	Cytoprotective Effects of Oleanolic Acid in Human Umbilical Vascular Endothelial Cells is Mediated Via UCP2/ROS/Cytochrome C/AIF Pathway.	Oleanolic Acid	26-40	cytochrome c, somatic	Homo sapiens	112-124
26771154-0	2016	Cytoprotective Effects of Oleanolic Acid in Human Umbilical Vascular Endothelial Cells is Mediated Via UCP2/ROS/Cytochrome C/AIF Pathway.	Oleanolic Acid	26-40	apoptosis inducing factor mitochondria associated 1	Homo sapiens	125-128
26750249-4	2016	Good results were determined for oleanolic acid derived 7 for tumor cell lines 518A2 (melanoma, EC50=3.3 muM), A2780 (ovarian carcinoma, EC50=3.4 muM) and HT29 (colon adenocarcinoma, EC50=5.6 muM) while being significantly less cytotoxic for fibroblasts (EC50=20.4 muM).	Oleanolic Acid	33-47	latexin	Homo sapiens	105-108
26547583-0	2016	The dual induction of apoptosis and autophagy by SZC014, a synthetic oleanolic acid derivative, in gastric cancer cells via NF-kappaB pathway.	Oleanolic Acid	69-83	nuclear factor kappa B subunit 1	Homo sapiens	124-133
26750249-4	2016	Good results were determined for oleanolic acid derived 7 for tumor cell lines 518A2 (melanoma, EC50=3.3 muM), A2780 (ovarian carcinoma, EC50=3.4 muM) and HT29 (colon adenocarcinoma, EC50=5.6 muM) while being significantly less cytotoxic for fibroblasts (EC50=20.4 muM).	Oleanolic Acid	33-47	latexin	Homo sapiens	146-149
26750249-4	2016	Good results were determined for oleanolic acid derived 7 for tumor cell lines 518A2 (melanoma, EC50=3.3 muM), A2780 (ovarian carcinoma, EC50=3.4 muM) and HT29 (colon adenocarcinoma, EC50=5.6 muM) while being significantly less cytotoxic for fibroblasts (EC50=20.4 muM).	Oleanolic Acid	33-47	latexin	Homo sapiens	146-149
26750249-4	2016	Good results were determined for oleanolic acid derived 7 for tumor cell lines 518A2 (melanoma, EC50=3.3 muM), A2780 (ovarian carcinoma, EC50=3.4 muM) and HT29 (colon adenocarcinoma, EC50=5.6 muM) while being significantly less cytotoxic for fibroblasts (EC50=20.4 muM).	Oleanolic Acid	33-47	latexin	Homo sapiens	146-149
26777089-4	2016	Two natural well known HNE inhibitors from the triterpene family, ursolic acid and oleanolic acid, were tested to validate the developed assay.	Oleanolic Acid	83-97	elastase, neutrophil expressed	Homo sapiens	23-26
26625716-1	2016	Oleanolic acid (OA) is a typical BCS IV drug with low water-solubility and poor permeability, metabolized by cytochrome P450 (CYP) isozymes in the intestinal tract, such as CYP3A.	Oleanolic Acid	0-14	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	173-178
26625716-1	2016	Oleanolic acid (OA) is a typical BCS IV drug with low water-solubility and poor permeability, metabolized by cytochrome P450 (CYP) isozymes in the intestinal tract, such as CYP3A.	Oleanolic Acid	16-18	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	173-178
28003581-7	2016	Asiatic acid, corosolic acid, glycyrrhetinic acid, oleanolic acid and ursolic acid suppressed octanoylated ghrelin levels in AGS-GHRL8 cells without decreasing transcript expression of GOAT or furin, a protease required for ghrelin maturation.	Oleanolic Acid	51-65	appetite-regulating hormone	Capra hircus	107-114
27373628-7	2016	Oleanolic acid, a positive control, inhibited PTP1B activity at 0.7+-0.1 microM (IC50) in the same experiment.	Oleanolic Acid	0-14	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	46-51
26460147-0	2015	Betulinic acid and oleanolic acid, natural pentacyclic triterpenoids, interfere with N-linked glycan modifications to intercellular adhesion molecule-1, but not its intracellular transport to the cell surface.	Oleanolic Acid	19-33	intercellular adhesion molecule 1	Homo sapiens	118-151
26709651-2	2016	Here, we studied the expression of Syt1 in Apoe-deficient mice receiving cholesterol, Western diet, squalene, and oleanolic acid.	Oleanolic Acid	114-128	synaptotagmin I	Mus musculus	35-39
26362502-0	2015	Proapoptotic activity and ABCC1-related multidrug resistance reduction ability of semisynthetic oleanolic acid derivatives DIOXOL and HIMOXOL in human acute promyelocytic leukemia cells.	Oleanolic Acid	96-110	ATP binding cassette subfamily C member 1	Homo sapiens	26-31
26592451-0	2015	Oleanolic acid activates daf-16 to increase lifespan in Caenorhabditis elegans.	Oleanolic Acid	0-14	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	25-31
26362502-3	2015	This paper examines the influence of eight semisynthetic oleanolic acid derivatives on drug-sensitive human acute promyelocytic leukemia cell line HL-60 and its multidrug resistant subline ABCC1 overexpressing HL-60/AR.	Oleanolic Acid	57-71	ATP binding cassette subfamily C member 1	Homo sapiens	189-194
26460147-4	2015	Nevertheless, betulinic acid and, to a lesser extent, oleanolic acid interfered with N-linked glycan modifications to ICAM-1 in a similar manner to castanospermine (an inhibitor of endoplasmic reticulum alpha-glucosidases I and II), but not swainsonine (an inhibitor of Golgi alpha-mannosidase II).	Oleanolic Acid	54-68	intercellular adhesion molecule 1	Homo sapiens	118-124
26460147-4	2015	Nevertheless, betulinic acid and, to a lesser extent, oleanolic acid interfered with N-linked glycan modifications to ICAM-1 in a similar manner to castanospermine (an inhibitor of endoplasmic reticulum alpha-glucosidases I and II), but not swainsonine (an inhibitor of Golgi alpha-mannosidase II).	Oleanolic Acid	54-68	mannosidase alpha class 2A member 1	Homo sapiens	270-296
26460147-6	2015	Thus, to the best of our knowledge, this is the first study to show that betulinic acid and oleanolic acid interfere with N-linked glycan modifications to ICAM-1, but not its intracellular transport to the cell surface.	Oleanolic Acid	92-106	intercellular adhesion molecule 1	Homo sapiens	155-161
26823699-0	2015	Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	71-74
26823699-0	2015	Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling.	Oleanolic Acid	0-14	mechanistic target of rapamycin kinase	Homo sapiens	75-79
26823699-0	2015	Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling.	Oleanolic Acid	0-14	ribosomal protein S6 kinase B1	Homo sapiens	80-83
26823699-0	2015	Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling.	Oleanolic Acid	0-14	mitogen-activated protein kinase 3	Homo sapiens	88-94
26823699-4	2015	In this study, we found that the anti-cancer effect of oleanolic acid significantly suppressed cell proliferation and increased apoptosis and caspase-3 activity of T24 cells.	Oleanolic Acid	55-69	caspase 3	Homo sapiens	142-151
26823699-5	2015	Furthermore, Akt, mTOR and S6K protein expression was greatly inhibited in T24 cells under oleanolic acid treatment.	Oleanolic Acid	91-105	AKT serine/threonine kinase 1	Homo sapiens	13-16
26823699-5	2015	Furthermore, Akt, mTOR and S6K protein expression was greatly inhibited in T24 cells under oleanolic acid treatment.	Oleanolic Acid	91-105	mechanistic target of rapamycin kinase	Homo sapiens	18-22
26823699-5	2015	Furthermore, Akt, mTOR and S6K protein expression was greatly inhibited in T24 cells under oleanolic acid treatment.	Oleanolic Acid	91-105	ribosomal protein S6 kinase B1	Homo sapiens	27-30
26823699-6	2015	Meanwhile, ERK1/2 of phosphorylation protein expression was significantly promoted by oleanolic acid treatment.	Oleanolic Acid	86-100	mitogen-activated protein kinase 3	Homo sapiens	11-17
26823699-7	2015	Taken together, we provided evidences that oleanolic acid was Akt/mTOR/S6K and ERK1/2 signaling-targeting anti-tumor agent.	Oleanolic Acid	43-57	AKT serine/threonine kinase 1	Homo sapiens	62-65
26823699-7	2015	Taken together, we provided evidences that oleanolic acid was Akt/mTOR/S6K and ERK1/2 signaling-targeting anti-tumor agent.	Oleanolic Acid	43-57	mechanistic target of rapamycin kinase	Homo sapiens	66-70
26823699-7	2015	Taken together, we provided evidences that oleanolic acid was Akt/mTOR/S6K and ERK1/2 signaling-targeting anti-tumor agent.	Oleanolic Acid	43-57	ribosomal protein S6 kinase B1	Homo sapiens	71-74
26823699-7	2015	Taken together, we provided evidences that oleanolic acid was Akt/mTOR/S6K and ERK1/2 signaling-targeting anti-tumor agent.	Oleanolic Acid	43-57	mitogen-activated protein kinase 3	Homo sapiens	79-85
26823699-8	2015	These findings represent new evidences that oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling, and oleanolic acid may be used to prevent human bladder cancer.	Oleanolic Acid	44-58	AKT serine/threonine kinase 1	Homo sapiens	115-118
26823699-8	2015	These findings represent new evidences that oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling, and oleanolic acid may be used to prevent human bladder cancer.	Oleanolic Acid	44-58	mechanistic target of rapamycin kinase	Homo sapiens	119-123
26823699-8	2015	These findings represent new evidences that oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling, and oleanolic acid may be used to prevent human bladder cancer.	Oleanolic Acid	44-58	ribosomal protein S6 kinase B1	Homo sapiens	124-127
26823699-8	2015	These findings represent new evidences that oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling, and oleanolic acid may be used to prevent human bladder cancer.	Oleanolic Acid	44-58	mitogen-activated protein kinase 3	Homo sapiens	132-138
24728886-0	2015	Oleanolic acid derivatives induce apoptosis in human leukemia K562 cell involved in inhibition of both Akt1 translocation and pAkt1 expression.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	103-107
26297978-0	2015	Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
26297978-0	2015	Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism.	Oleanolic Acid	0-14	nuclear receptor subfamily 1, group H, member 4	Mus musculus	118-121
26393541-3	2015	We evaluated the effects of GTE and its major components, luteolin (lut), luteolin-7-glucoside (lut-7-g), and oleanolic acid (OA) on TNF-alpha-induced expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs).	Oleanolic Acid	110-124	tumor necrosis factor	Homo sapiens	133-142
26253631-4	2015	Oleanolic acid, a positive control, inhibited PTP1B activity at 0.7 muM (IC50).	Oleanolic Acid	0-14	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	46-51
26253631-4	2015	Oleanolic acid, a positive control, inhibited PTP1B activity at 0.7 muM (IC50).	Oleanolic Acid	0-14	latexin	Homo sapiens	68-71
26957994-2	2015	AIMS: To determine the influence of subtle difference in the structure of oleanolic acid and betulinic acid towards the inhibition towards the activity of UGT isoforms.	Oleanolic Acid	74-88	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	155-158
26957994-4	2015	RESULTS: The inhibition of capability of oleanolic acid towards UGT1A6 and UGT1A8 were higher than betulinic acid.	Oleanolic Acid	41-55	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	64-70
26957994-6	2015	Furthermore, concentration-dependent behaviour was determined for the inhibition of oleanolic acid and betulinic acid towards UGT1A6 and UGT1A8.	Oleanolic Acid	84-98	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	126-132
26957994-4	2015	RESULTS: The inhibition of capability of oleanolic acid towards UGT1A6 and UGT1A8 were higher than betulinic acid.	Oleanolic Acid	41-55	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	75-81
26207761-4	2015	Furthermore, for 3,28-O-bidesmosides, sugar-substituted moieties attached to the C-3 and C-28 positions of the oleanolic acid scaffold are helpful to increase the inhibitory activities against alpha-amylase and alpha-glucosidase.	Oleanolic Acid	111-125	complement C3	Homo sapiens	81-84
26957994-6	2015	Furthermore, concentration-dependent behaviour was determined for the inhibition of oleanolic acid and betulinic acid towards UGT1A6 and UGT1A8.	Oleanolic Acid	84-98	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	137-143
26957994-7	2015	At various concentrations of oleanolic acid and betulinic acid, the inhibition of oleanolic acid towards UGT1A6 and UGT1A8 was higher than betulinic acid.	Oleanolic Acid	29-43	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	105-111
26957994-7	2015	At various concentrations of oleanolic acid and betulinic acid, the inhibition of oleanolic acid towards UGT1A6 and UGT1A8 was higher than betulinic acid.	Oleanolic Acid	29-43	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	116-122
26957994-7	2015	At various concentrations of oleanolic acid and betulinic acid, the inhibition of oleanolic acid towards UGT1A6 and UGT1A8 was higher than betulinic acid.	Oleanolic Acid	82-96	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	105-111
26957994-7	2015	At various concentrations of oleanolic acid and betulinic acid, the inhibition of oleanolic acid towards UGT1A6 and UGT1A8 was higher than betulinic acid.	Oleanolic Acid	82-96	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	116-122
26957994-8	2015	CONSLUSION: Given that UGT1A6 and UGT1A8 play key role in the the inhibition of oleanolic acid towards UGT1A6 and UGT1A8 will induce drug-drug interaction and the risk of diseases.	Oleanolic Acid	80-94	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	23-29
26957994-8	2015	CONSLUSION: Given that UGT1A6 and UGT1A8 play key role in the the inhibition of oleanolic acid towards UGT1A6 and UGT1A8 will induce drug-drug interaction and the risk of diseases.	Oleanolic Acid	80-94	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	34-40
26957994-8	2015	CONSLUSION: Given that UGT1A6 and UGT1A8 play key role in the the inhibition of oleanolic acid towards UGT1A6 and UGT1A8 will induce drug-drug interaction and the risk of diseases.	Oleanolic Acid	80-94	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	103-109
26957994-8	2015	CONSLUSION: Given that UGT1A6 and UGT1A8 play key role in the the inhibition of oleanolic acid towards UGT1A6 and UGT1A8 will induce drug-drug interaction and the risk of diseases.	Oleanolic Acid	80-94	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	114-120
26207761-4	2015	Furthermore, for 3,28-O-bidesmosides, sugar-substituted moieties attached to the C-3 and C-28 positions of the oleanolic acid scaffold are helpful to increase the inhibitory activities against alpha-amylase and alpha-glucosidase.	Oleanolic Acid	111-125	sucrase-isomaltase	Homo sapiens	211-228
26223130-1	2015	Thirteen novel oleanolic acid (OA) derivatives were designed and synthesized with modification at positions of C-3, C-12 and C-28 of OA.	Oleanolic Acid	15-29	complement C3	Homo sapiens	111-114
26107166-4	2015	Here we report that TGR5 is involved in mediating the anti-obesity and anti-hyperglycemia effect of a natural compound, oleanolic acid.	Oleanolic Acid	120-134	G protein-coupled bile acid receptor 1	Mus musculus	20-24
26223130-1	2015	Thirteen novel oleanolic acid (OA) derivatives were designed and synthesized with modification at positions of C-3, C-12 and C-28 of OA.	Oleanolic Acid	31-33	complement C3	Homo sapiens	111-114
25472877-0	2015	Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis.	Oleanolic Acid	0-14	microRNA 122	Homo sapiens	71-78
24954090-0	2015	Discovery, optimization, and pharmacophore modeling of oleanolic acid and analogues as breast cancer cell migration and invasion inhibitors through targeting Brk/Paxillin/Rac1 axis.	Oleanolic Acid	55-69	protein tyrosine kinase 6	Homo sapiens	158-161
24954090-0	2015	Discovery, optimization, and pharmacophore modeling of oleanolic acid and analogues as breast cancer cell migration and invasion inhibitors through targeting Brk/Paxillin/Rac1 axis.	Oleanolic Acid	55-69	paxillin	Homo sapiens	162-170
24954090-0	2015	Discovery, optimization, and pharmacophore modeling of oleanolic acid and analogues as breast cancer cell migration and invasion inhibitors through targeting Brk/Paxillin/Rac1 axis.	Oleanolic Acid	55-69	Rac family small GTPase 1	Homo sapiens	171-175
24954090-8	2015	This study is the first to discover the antimigratory and anti-invasive activities of oleanolic acid and analogues through targeting the Brk/Paxillin/Rac1 axis.	Oleanolic Acid	86-100	protein tyrosine kinase 6	Homo sapiens	137-140
24954090-8	2015	This study is the first to discover the antimigratory and anti-invasive activities of oleanolic acid and analogues through targeting the Brk/Paxillin/Rac1 axis.	Oleanolic Acid	86-100	paxillin	Homo sapiens	141-149
24954090-8	2015	This study is the first to discover the antimigratory and anti-invasive activities of oleanolic acid and analogues through targeting the Brk/Paxillin/Rac1 axis.	Oleanolic Acid	86-100	Rac family small GTPase 1	Homo sapiens	150-154
25472877-0	2015	Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis.	Oleanolic Acid	0-14	cyclin G1	Homo sapiens	79-88
25472877-0	2015	Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis.	Oleanolic Acid	0-14	myocyte enhancer factor 2D	Homo sapiens	89-94
25280775-0	2015	Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2.	Oleanolic Acid	54-68	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
25636872-7	2015	Moreover, the presence of hydroxyl group at C-2 position of triterpenic acid in MA compared with oleanolic acid could magnify its competitive inhibition on human CYP3A4 activity.	Oleanolic Acid	97-111	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	162-168
25280775-0	2015	Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2.	Oleanolic Acid	54-68	solute carrier organic anion transporter family, member 1b2	Mus musculus	113-120
25280775-1	2015	This study utilized pharmacological activation of Nrf2 with oleanolic acid (OA, 22.5mg/kg, sc for 4 days) and the genetic alteration of Nrf2 (Nrf2-null, wild-type, and Keap1-HKO mice) to examine the role of Nrf2 in protection against phalloidin hepatotoxicity.	Oleanolic Acid	60-74	nuclear factor, erythroid derived 2, like 2	Mus musculus	50-54
26205959-0	2015	alpha-Glucosidase activity of oleanolic acid and its oxidative metabolites: DFT and Docking studies.	Oleanolic Acid	30-44	sucrase-isomaltase	Homo sapiens	0-17
26843885-0	2015	Oleanolic Acid Attenuates Insulin Resistance via NF-kappaB to Regulate the IRS1-GLUT4 Pathway in HepG2 Cells.	Oleanolic Acid	0-14	insulin	Homo sapiens	26-33
26843885-0	2015	Oleanolic Acid Attenuates Insulin Resistance via NF-kappaB to Regulate the IRS1-GLUT4 Pathway in HepG2 Cells.	Oleanolic Acid	0-14	nuclear factor kappa B subunit 1	Homo sapiens	49-58
26843885-0	2015	Oleanolic Acid Attenuates Insulin Resistance via NF-kappaB to Regulate the IRS1-GLUT4 Pathway in HepG2 Cells.	Oleanolic Acid	0-14	insulin receptor substrate 1	Homo sapiens	75-79
26843885-0	2015	Oleanolic Acid Attenuates Insulin Resistance via NF-kappaB to Regulate the IRS1-GLUT4 Pathway in HepG2 Cells.	Oleanolic Acid	0-14	solute carrier family 2 member 4	Homo sapiens	80-85
26843885-1	2015	The aim of our study is to elucidate the mechanisms of oleanolic acid (OA) on insulin resistance (IR) in HepG2 cells.	Oleanolic Acid	55-69	insulin	Homo sapiens	78-85
26843885-1	2015	The aim of our study is to elucidate the mechanisms of oleanolic acid (OA) on insulin resistance (IR) in HepG2 cells.	Oleanolic Acid	71-73	insulin	Homo sapiens	78-85
26205959-1	2015	A natural pentacyclic triterpenoid oleanolic acid 1 and its biotransformed metabolites 2-3 are potential alpha-glucosidase inhibitors.	Oleanolic Acid	35-49	sucrase-isomaltase	Homo sapiens	105-122
25172632-0	2014	Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy.	Oleanolic Acid	0-14	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	58-62
25304374-6	2014	Inhibition of AKR1B10 by oleanolic acid (OA) showed a dose-dependent inhibition of cell growth with IC50 at 30 microM.	Oleanolic Acid	25-39	aldo-keto reductase family 1 member B10	Homo sapiens	14-21
25240313-0	2014	Comment on: Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulation (sic) in rats.	Oleanolic Acid	12-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	91-96
25404917-5	2014	The TGR5 ligand oleanolic acid (OA) stimulated Galphas and cAMP formation, and caused GLP-1 and PYY release.	Oleanolic Acid	16-30	G protein-coupled bile acid receptor 1	Rattus norvegicus	4-8
25404917-5	2014	The TGR5 ligand oleanolic acid (OA) stimulated Galphas and cAMP formation, and caused GLP-1 and PYY release.	Oleanolic Acid	16-30	glucagon	Rattus norvegicus	86-91
25404917-5	2014	The TGR5 ligand oleanolic acid (OA) stimulated Galphas and cAMP formation, and caused GLP-1 and PYY release.	Oleanolic Acid	16-30	peptide YY	Rattus norvegicus	96-99
26713087-3	2015	PPARgamma, a ligand activated transcription factor, has long been studied for its anti-inflammatory actions, but an emerging body of literature is investigating the role of PPARgamma and its ligands (including thiazolidinediones, prostaglandins, and oleanolic acids) in all phases of resolution.	Oleanolic Acid	250-265	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
26240574-0	2015	Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5.	Oleanolic Acid	0-14	NK2 homeobox 5	Homo sapiens	111-118
25264584-0	2014	Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.	Oleanolic Acid	13-27	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	85-91
25264584-2	2014	Pentacyclic acid triterpenes such as oleanolic acid (OA) have proved to be excellent PTP-1B inhibitors, thus, the purpose of current work was to generate a series of derivatives that improve the pharmacological effect of OA.	Oleanolic Acid	37-51	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	85-91
25264584-2	2014	Pentacyclic acid triterpenes such as oleanolic acid (OA) have proved to be excellent PTP-1B inhibitors, thus, the purpose of current work was to generate a series of derivatives that improve the pharmacological effect of OA.	Oleanolic Acid	53-55	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	85-91
25264584-7	2014	In conclusion, oleanolic acid derivatives have revealed an enhanced inhibitory effect over PTP-1B activity by increasing molecular interactions with either catalytic or allosteric sites and producing a hypoglycaemic effect on non insulin dependent diabetes mellitus rat model.	Oleanolic Acid	15-29	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	91-97
24920136-9	2014	Although monoamine oxidase activity remained unaltered by oleanolic acid, chronic administration of oleanolic acid augmented hippocampal BDNF level.	Oleanolic Acid	100-114	brain derived neurotrophic factor	Mus musculus	137-141
25087096-10	2014	A natural compound, oleanolic acid, was demonstrated to suppress the invasion and EMT of HCC cells by downregulating MEF2, showing that targeting this pathway is an effective therapeutic strategy for HCC invasion.	Oleanolic Acid	20-34	myocyte enhancer factor 2A	Homo sapiens	117-121
24997455-8	2014	Additionally, oleanolic acid normalized the MK-801-induced alterations of signaling molecules including phosphorylation levels of Akt and GSK-3beta in the frontal cortex.	Oleanolic Acid	14-28	thymoma viral proto-oncogene 1	Mus musculus	130-133
24997455-8	2014	Additionally, oleanolic acid normalized the MK-801-induced alterations of signaling molecules including phosphorylation levels of Akt and GSK-3beta in the frontal cortex.	Oleanolic Acid	14-28	glycogen synthase kinase 3 beta	Mus musculus	138-147
24706573-0	2014	Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts.	Oleanolic Acid	58-72	mitogen-activated protein kinase 14	Homo sapiens	14-17
24706573-0	2014	Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts.	Oleanolic Acid	58-72	mitogen-activated protein kinase 1	Homo sapiens	18-22
24706573-0	2014	Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts.	Oleanolic Acid	58-72	mitogen-activated protein kinase 8	Homo sapiens	27-30
25111957-0	2014	Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulating in rats.	Oleanolic Acid	0-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-84
25113933-0	2014	Oleanolic acid analogs as NO, TNF-alpha and IL-1beta inhibitors: synthesis, biological evaluation and docking studies.	Oleanolic Acid	0-14	tumor necrosis factor	Mus musculus	30-39
25222566-0	2014	Hepatic FoxO1 acetylation is involved in oleanolic acid-induced memory of glycemic control: novel findings from Study 2.	Oleanolic Acid	41-55	forkhead box O1	Mus musculus	8-13
25113933-0	2014	Oleanolic acid analogs as NO, TNF-alpha and IL-1beta inhibitors: synthesis, biological evaluation and docking studies.	Oleanolic Acid	0-14	interleukin 1 beta	Mus musculus	44-52
25059280-0	2014	Oleanolic acid regulates NF-kappaB signaling by suppressing MafK expression in RAW 264.7 cells.	Oleanolic Acid	0-14	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	Mus musculus	60-64
25113933-2	2014	Results revealed that all the synthesized analogs of oleanolic acid inhibit NO production with an IC50 of 2.66-41.7 muM as compared to the specific nitric oxide synthase (NOS) inhibitor, L-NAME (IC50=69.21 and 73.18 muM on RAW 264.7 and J774A.1 cells, respectively) without affecting the cell viability when tested at their half maximal concentration.	Oleanolic Acid	53-67	nitric oxide synthase 1, neuronal	Mus musculus	148-169
25059280-9	2014	Among the compounds, oleanolic acid significantly decreased MafK expression and MafK-mediated p65 acetylation.	Oleanolic Acid	21-35	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	Mus musculus	60-64
25059280-9	2014	Among the compounds, oleanolic acid significantly decreased MafK expression and MafK-mediated p65 acetylation.	Oleanolic Acid	21-35	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	Mus musculus	80-84
24842472-1	2014	Our previous study found that caveolin-1 (CAV-1) protein expression is upregulated during oleanolic acid (OA)-induced inhibition of proliferation and promotion of apoptosis in HL-60 cells.	Oleanolic Acid	106-108	caveolin 1	Homo sapiens	30-40
25059280-9	2014	Among the compounds, oleanolic acid significantly decreased MafK expression and MafK-mediated p65 acetylation.	Oleanolic Acid	21-35	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	94-97
25079084-0	2014	BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice.	Oleanolic Acid	90-104	brain derived neurotrophic factor	Mus musculus	0-4
25079084-0	2014	BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice.	Oleanolic Acid	90-104	mitogen-activated protein kinase 1	Mus musculus	5-8
25079084-0	2014	BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice.	Oleanolic Acid	90-104	cAMP responsive element binding protein 1	Mus musculus	9-13
25079084-0	2014	BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice.	Oleanolic Acid	90-104	microRNA 132	Mus musculus	46-53
25079084-1	2014	BACKGROUND: Although previous study has demonstrated that brain-derived neurotrophic factor (BDNF) is involved in the antidepressant-like effect of oleanolic acid, there is little information regarding the details of the molecular mechanism involved in this effect.	Oleanolic Acid	148-162	brain derived neurotrophic factor	Mus musculus	58-91
25079084-1	2014	BACKGROUND: Although previous study has demonstrated that brain-derived neurotrophic factor (BDNF) is involved in the antidepressant-like effect of oleanolic acid, there is little information regarding the details of the molecular mechanism involved in this effect.	Oleanolic Acid	148-162	brain derived neurotrophic factor	Mus musculus	93-97
25079084-3	2014	Furthermore, we explored the possible signalling pathways associated with miR-132 expression that mediate the effect of oleanolic acid on neuronal proliferation.	Oleanolic Acid	120-134	microRNA 132	Mus musculus	74-81
25079084-5	2014	Furthermore, we found that oleanolic acid led to the BDNF-related phosphorylation and activation of extracellular signal-regulated kinases (ERK) and cyclic adenosine monophosphate response element binding protein (CREB), which was associated with the upregulation of miR-132 and hippocampal neuronal proliferation.	Oleanolic Acid	27-41	brain derived neurotrophic factor	Mus musculus	53-57
25079084-5	2014	Furthermore, we found that oleanolic acid led to the BDNF-related phosphorylation and activation of extracellular signal-regulated kinases (ERK) and cyclic adenosine monophosphate response element binding protein (CREB), which was associated with the upregulation of miR-132 and hippocampal neuronal proliferation.	Oleanolic Acid	27-41	mitogen-activated protein kinase 1	Mus musculus	100-138
25079084-5	2014	Furthermore, we found that oleanolic acid led to the BDNF-related phosphorylation and activation of extracellular signal-regulated kinases (ERK) and cyclic adenosine monophosphate response element binding protein (CREB), which was associated with the upregulation of miR-132 and hippocampal neuronal proliferation.	Oleanolic Acid	27-41	mitogen-activated protein kinase 1	Mus musculus	140-143
25079084-5	2014	Furthermore, we found that oleanolic acid led to the BDNF-related phosphorylation and activation of extracellular signal-regulated kinases (ERK) and cyclic adenosine monophosphate response element binding protein (CREB), which was associated with the upregulation of miR-132 and hippocampal neuronal proliferation.	Oleanolic Acid	27-41	cAMP responsive element binding protein 1	Mus musculus	214-218
25079084-5	2014	Furthermore, we found that oleanolic acid led to the BDNF-related phosphorylation and activation of extracellular signal-regulated kinases (ERK) and cyclic adenosine monophosphate response element binding protein (CREB), which was associated with the upregulation of miR-132 and hippocampal neuronal proliferation.	Oleanolic Acid	27-41	microRNA 132	Mus musculus	267-274
25079084-9	2014	CONCLUSION: Our results show that oleanolic acid induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways.	Oleanolic Acid	34-48	microRNA 132	Mus musculus	77-84
25079084-9	2014	CONCLUSION: Our results show that oleanolic acid induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways.	Oleanolic Acid	34-48	brain derived neurotrophic factor	Mus musculus	199-203
25079084-9	2014	CONCLUSION: Our results show that oleanolic acid induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways.	Oleanolic Acid	34-48	mitogen-activated protein kinase 1	Mus musculus	204-207
25079084-9	2014	CONCLUSION: Our results show that oleanolic acid induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways.	Oleanolic Acid	34-48	cAMP responsive element binding protein 1	Mus musculus	208-212
25187683-4	2014	Therefore, the predicted structure of HBx using threading in LOMET was used for docking against plant derived natural compounds (curcumin, oleanolic acid, resveratrol, bilobetin, luteoline, ellagic acid, betulinic acid and rutin) by Molegro Virtual Docker.	Oleanolic Acid	139-153	X protein	Hepatitis B virus	38-41
24912497-0	2014	Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways.	Oleanolic Acid	0-14	mitogen-activated protein kinase 8	Homo sapiens	72-75
24912497-0	2014	Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways.	Oleanolic Acid	0-14	mechanistic target of rapamycin kinase	Homo sapiens	80-84
24842472-0	2014	Caveolin-1 plays a key role in the oleanolic acid-induced apoptosis of HL-60 cells.	Oleanolic Acid	35-49	caveolin 1	Homo sapiens	0-10
24842472-1	2014	Our previous study found that caveolin-1 (CAV-1) protein expression is upregulated during oleanolic acid (OA)-induced inhibition of proliferation and promotion of apoptosis in HL-60 cells.	Oleanolic Acid	90-104	caveolin 1	Homo sapiens	30-40
24842472-1	2014	Our previous study found that caveolin-1 (CAV-1) protein expression is upregulated during oleanolic acid (OA)-induced inhibition of proliferation and promotion of apoptosis in HL-60 cells.	Oleanolic Acid	90-104	caveolin 1	Homo sapiens	42-47
24842472-1	2014	Our previous study found that caveolin-1 (CAV-1) protein expression is upregulated during oleanolic acid (OA)-induced inhibition of proliferation and promotion of apoptosis in HL-60 cells.	Oleanolic Acid	106-108	caveolin 1	Homo sapiens	42-47
24856665-0	2014	Oleanolic acid induces metabolic adaptation in cancer cells by activating the AMP-activated protein kinase pathway.	Oleanolic Acid	0-14	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	78-106
25272488-4	2014	RESULT: Increasing gene copies of GgbAS, MtOAS and AtCPR1 resulted in increased beta-amyrin and oleanolic acid production.	Oleanolic Acid	96-110	F-box and associated interaction domains-containing protein	Arabidopsis thaliana	51-57
24824325-0	2014	Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	52-55
24824325-0	2014	Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways.	Oleanolic Acid	0-14	mitogen-activated protein kinase 8	Homo sapiens	60-63
24604140-0	2014	Oleanolic acid enhances the radiosensitivity of tumor cells under mimetic hypoxia through the reduction in intracellular GSH content and HIF-1alpha expression.	Oleanolic Acid	0-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-147
24721313-0	2014	Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors.	Oleanolic Acid	36-50	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	70-101
24721313-1	2014	Sixteen novel oleanolic acid triterpenoid saponins were synthesized in an efficient and practical strategy, and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and selectivity over T-cell protein tyrosine phosphatase (TCPTP) were evaluated in vitro.	Oleanolic Acid	14-28	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	148-179
24721313-1	2014	Sixteen novel oleanolic acid triterpenoid saponins were synthesized in an efficient and practical strategy, and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and selectivity over T-cell protein tyrosine phosphatase (TCPTP) were evaluated in vitro.	Oleanolic Acid	14-28	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	181-186
24721313-1	2014	Sixteen novel oleanolic acid triterpenoid saponins were synthesized in an efficient and practical strategy, and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and selectivity over T-cell protein tyrosine phosphatase (TCPTP) were evaluated in vitro.	Oleanolic Acid	14-28	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	209-244
24721313-1	2014	Sixteen novel oleanolic acid triterpenoid saponins were synthesized in an efficient and practical strategy, and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and selectivity over T-cell protein tyrosine phosphatase (TCPTP) were evaluated in vitro.	Oleanolic Acid	14-28	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	246-251
24704288-0	2014	Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats.	Oleanolic Acid	0-14	insulin receptor substrate 1	Rattus norvegicus	107-135
24704288-0	2014	Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Rattus norvegicus	166-169
24704288-8	2014	At the protein level, oleanolic acid upregulated total IRS-1 expression, suppressed the increased phosphorylated IRS-1 at serine-307, and restored the increased phosphorylated IRS-1 to total IRS-1 ratio.	Oleanolic Acid	22-36	insulin receptor substrate 1	Rattus norvegicus	55-60
24704288-8	2014	At the protein level, oleanolic acid upregulated total IRS-1 expression, suppressed the increased phosphorylated IRS-1 at serine-307, and restored the increased phosphorylated IRS-1 to total IRS-1 ratio.	Oleanolic Acid	22-36	insulin receptor substrate 1	Rattus norvegicus	113-118
24704288-8	2014	At the protein level, oleanolic acid upregulated total IRS-1 expression, suppressed the increased phosphorylated IRS-1 at serine-307, and restored the increased phosphorylated IRS-1 to total IRS-1 ratio.	Oleanolic Acid	22-36	insulin receptor substrate 1	Rattus norvegicus	113-118
24704288-8	2014	At the protein level, oleanolic acid upregulated total IRS-1 expression, suppressed the increased phosphorylated IRS-1 at serine-307, and restored the increased phosphorylated IRS-1 to total IRS-1 ratio.	Oleanolic Acid	22-36	insulin receptor substrate 1	Rattus norvegicus	113-118
24704288-10	2014	Furthermore, oleanolic acid reversed fructose-induced decrease in phosphorylated-Akt/Akt protein to plasma insulin concentration ratio.	Oleanolic Acid	13-27	AKT serine/threonine kinase 1	Rattus norvegicus	81-84
24704288-10	2014	Furthermore, oleanolic acid reversed fructose-induced decrease in phosphorylated-Akt/Akt protein to plasma insulin concentration ratio.	Oleanolic Acid	13-27	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
24704288-12	2014	Therefore, these results suggest that oleanolic acid supplement ameliorates fructose-induced Adipo-IR in rats via the IRS-1/phosphatidylinositol 3-kinase/Akt pathway.	Oleanolic Acid	38-52	insulin receptor substrate 1	Rattus norvegicus	118-123
24704288-12	2014	Therefore, these results suggest that oleanolic acid supplement ameliorates fructose-induced Adipo-IR in rats via the IRS-1/phosphatidylinositol 3-kinase/Akt pathway.	Oleanolic Acid	38-52	AKT serine/threonine kinase 1	Rattus norvegicus	154-157
24626155-4	2014	In this study, we found that Oleanolic acid (OA) induced a switch from PKM2 to PKM1, and consistently, abrogated Warburg effect in cancer cells.	Oleanolic Acid	29-43	pyruvate kinase M1/2	Homo sapiens	71-75
24491315-8	2014	Kinetic studies showed that OLA behaved as a competitive inhibitor of substrate-mediated MRP-1 transport, whereas MLA acted as a non-competitive one.	Oleanolic Acid	28-31	ATP binding cassette subfamily C member 1	Homo sapiens	89-94
24491315-10	2014	In summary, OLA or MLA sensitized cellular models of STS to DXR and selectively inhibited MRP-1 activity, but not its expression, leading to a higher antitumoral effect possibly relevant for clinical treatment.	Oleanolic Acid	12-15	ATP binding cassette subfamily C member 1	Homo sapiens	90-95
24422538-0	2014	Combination of amino acid/dipeptide with nitric oxide donating oleanolic acid derivatives as PepT1 targeting antitumor prodrugs.	Oleanolic Acid	63-77	solute carrier family 15 member 1	Homo sapiens	93-98
24487188-1	2014	Six novel oleanolic acid ring-A fused hybrids (5-10) have been synthesized by employing a four step protocol with the introduction of benzylidene functionality at C-2 as the key step.	Oleanolic Acid	10-24	complement C2	Homo sapiens	163-166
24459190-0	2014	Blockade of visfatin induction by oleanolic acid via disturbing IL-6-TRAF6-NF-kappaB signaling of adipocytes.	Oleanolic Acid	34-48	nicotinamide phosphoribosyltransferase	Homo sapiens	12-20
24459190-0	2014	Blockade of visfatin induction by oleanolic acid via disturbing IL-6-TRAF6-NF-kappaB signaling of adipocytes.	Oleanolic Acid	34-48	interleukin 6	Homo sapiens	64-68
24459190-0	2014	Blockade of visfatin induction by oleanolic acid via disturbing IL-6-TRAF6-NF-kappaB signaling of adipocytes.	Oleanolic Acid	34-48	TNF receptor associated factor 6	Homo sapiens	69-74
24459190-0	2014	Blockade of visfatin induction by oleanolic acid via disturbing IL-6-TRAF6-NF-kappaB signaling of adipocytes.	Oleanolic Acid	34-48	nuclear factor kappa B subunit 1	Homo sapiens	75-84
24459190-2	2014	The current study elucidated that oleanolic acid inhibited the production of insulin-mimetic and inflammatory adipokine of visfatin during adipogenic differentiation of 3T3-L1 adipocytes.	Oleanolic Acid	34-48	nicotinamide phosphoribosyltransferase	Homo sapiens	123-131
24459190-4	2014	The cellular expression and secretion of visfatin was markedly enhanced in differentiating adipocytes, which was dose-dependently attenuated by 1-25 microM oleanolic acid.	Oleanolic Acid	156-170	nicotinamide phosphoribosyltransferase	Homo sapiens	41-49
24459190-8	2014	NF-kappaB was activated by translocating into the nucleus with increased phosphorylation of inhibitory kappaB (IkappaB), which was disturbed by oleanolic acid.	Oleanolic Acid	144-158	nuclear factor kappa B subunit 1	Homo sapiens	0-9
24459190-11	2014	These results demonstrate that oleanolic acid inhibited visfatin and its inflammatory response during adipocyte differentiation through blocking IL-6-TRAF6-NF-kappaB signaling.	Oleanolic Acid	31-45	nicotinamide phosphoribosyltransferase	Homo sapiens	56-64
24459190-11	2014	These results demonstrate that oleanolic acid inhibited visfatin and its inflammatory response during adipocyte differentiation through blocking IL-6-TRAF6-NF-kappaB signaling.	Oleanolic Acid	31-45	interleukin 6	Homo sapiens	145-149
24459190-11	2014	These results demonstrate that oleanolic acid inhibited visfatin and its inflammatory response during adipocyte differentiation through blocking IL-6-TRAF6-NF-kappaB signaling.	Oleanolic Acid	31-45	TNF receptor associated factor 6	Homo sapiens	150-155
24459190-11	2014	These results demonstrate that oleanolic acid inhibited visfatin and its inflammatory response during adipocyte differentiation through blocking IL-6-TRAF6-NF-kappaB signaling.	Oleanolic Acid	31-45	nuclear factor kappa B subunit 1	Homo sapiens	156-165
24459190-12	2014	Therefore, oleanolic acid may be a potent therapeutic agent targeting against adipogenesis and visfatin-linked inflammation.	Oleanolic Acid	11-25	nicotinamide phosphoribosyltransferase	Homo sapiens	95-103
24548018-2	2014	In the current contribution, our central goal was to integratively dissect the biointeraction of two typical triterpenoids, ursolic acid and oleanolic acid, by the most fundamental macromolecule bovine serum albumin (BSA) by employing molecular modeling, steady state and time-resolved fluorescence, and circular dichroism spectra at the molecular scale.	Oleanolic Acid	141-155	albumin	Homo sapiens	202-215
24559268-0	2014	Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling.	Oleanolic Acid	23-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
24559268-0	2014	Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling.	Oleanolic Acid	23-37	heme oxygenase 1	Mus musculus	126-130
24559268-2	2014	This study investigated whether upregulation of Nrf2-dependent signaling by oleanolic acid (OA), which is known to activate Nrf2, could attenuate renal inflammation and fibrosis in cyclosporine (CsA)-induced kidney injury.	Oleanolic Acid	76-90	nuclear factor, erythroid derived 2, like 2	Mus musculus	48-52
24559268-2	2014	This study investigated whether upregulation of Nrf2-dependent signaling by oleanolic acid (OA), which is known to activate Nrf2, could attenuate renal inflammation and fibrosis in cyclosporine (CsA)-induced kidney injury.	Oleanolic Acid	76-90	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
24559268-2	2014	This study investigated whether upregulation of Nrf2-dependent signaling by oleanolic acid (OA), which is known to activate Nrf2, could attenuate renal inflammation and fibrosis in cyclosporine (CsA)-induced kidney injury.	Oleanolic Acid	92-94	nuclear factor, erythroid derived 2, like 2	Mus musculus	48-52
24559268-2	2014	This study investigated whether upregulation of Nrf2-dependent signaling by oleanolic acid (OA), which is known to activate Nrf2, could attenuate renal inflammation and fibrosis in cyclosporine (CsA)-induced kidney injury.	Oleanolic Acid	92-94	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
24422538-1	2014	By taking advantage of the cytotoxic effect of nitric oxide (NO) and PepT1 for molecule-targeted drug delivery, a series of amino acid/dipeptide diester prodrugs of NO-donating oleanolic acid derivatives were designed and synthesized.	Oleanolic Acid	177-191	solute carrier family 15 member 1	Homo sapiens	69-74
24636064-2	2014	In this study, uptake experiments were performed to assess the inhibitory effects of cinnamic acid, ferulic acid, oleanolic acid, deoxycholic acid, and cynarin on hOAT1, hOAT3, hOATP1B1, and hOATP2B1.	Oleanolic Acid	114-128	solute carrier family 22 member 6	Homo sapiens	163-168
24636064-2	2014	In this study, uptake experiments were performed to assess the inhibitory effects of cinnamic acid, ferulic acid, oleanolic acid, deoxycholic acid, and cynarin on hOAT1, hOAT3, hOATP1B1, and hOATP2B1.	Oleanolic Acid	114-128	solute carrier organic anion transporter family member 1B1	Homo sapiens	177-185
24374304-0	2014	Oleanolic acid suppresses ovalbumin-induced airway inflammation and Th2-mediated allergic asthma by modulating the transcription factors T-bet, GATA-3, RORgammat and Foxp3 in asthmatic mice.	Oleanolic Acid	0-14	heart and neural crest derivatives expressed 2	Mus musculus	68-71
24374304-0	2014	Oleanolic acid suppresses ovalbumin-induced airway inflammation and Th2-mediated allergic asthma by modulating the transcription factors T-bet, GATA-3, RORgammat and Foxp3 in asthmatic mice.	Oleanolic Acid	0-14	T-box 21	Mus musculus	137-142
24374304-0	2014	Oleanolic acid suppresses ovalbumin-induced airway inflammation and Th2-mediated allergic asthma by modulating the transcription factors T-bet, GATA-3, RORgammat and Foxp3 in asthmatic mice.	Oleanolic Acid	0-14	GATA binding protein 3	Mus musculus	144-150
24374304-0	2014	Oleanolic acid suppresses ovalbumin-induced airway inflammation and Th2-mediated allergic asthma by modulating the transcription factors T-bet, GATA-3, RORgammat and Foxp3 in asthmatic mice.	Oleanolic Acid	0-14	forkhead box P3	Mus musculus	166-171
24374304-4	2014	Oleanolic acid suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE through the upregulation of T-bet and Foxp3, and the downregulation of GATA-3 and RORgammat.	Oleanolic Acid	0-14	interleukin 5	Mus musculus	139-143
24374304-4	2014	Oleanolic acid suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE through the upregulation of T-bet and Foxp3, and the downregulation of GATA-3 and RORgammat.	Oleanolic Acid	0-14	interleukin 13	Mus musculus	145-150
24374304-4	2014	Oleanolic acid suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE through the upregulation of T-bet and Foxp3, and the downregulation of GATA-3 and RORgammat.	Oleanolic Acid	0-14	interleukin 17A	Mus musculus	152-157
24374304-4	2014	Oleanolic acid suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE through the upregulation of T-bet and Foxp3, and the downregulation of GATA-3 and RORgammat.	Oleanolic Acid	0-14	T-box 21	Mus musculus	214-219
24374304-4	2014	Oleanolic acid suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE through the upregulation of T-bet and Foxp3, and the downregulation of GATA-3 and RORgammat.	Oleanolic Acid	0-14	forkhead box P3	Mus musculus	224-229
24374304-4	2014	Oleanolic acid suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE through the upregulation of T-bet and Foxp3, and the downregulation of GATA-3 and RORgammat.	Oleanolic Acid	0-14	GATA binding protein 3	Mus musculus	257-263
24374304-5	2014	The therapeutic effect of oleanolic acid was due to suppression of Th2 cytokines (IL-5 and IL-13), B cell-dependent production of OVA-specific IgE, and Gr-1 expression through the T-bet, GATA-3, retinoic acid-related orphan receptor gamma t (RORgamma t) and forkhead box p3 (Foxp3) transcription pathways.	Oleanolic Acid	26-40	heart and neural crest derivatives expressed 2	Mus musculus	67-70
24374304-5	2014	The therapeutic effect of oleanolic acid was due to suppression of Th2 cytokines (IL-5 and IL-13), B cell-dependent production of OVA-specific IgE, and Gr-1 expression through the T-bet, GATA-3, retinoic acid-related orphan receptor gamma t (RORgamma t) and forkhead box p3 (Foxp3) transcription pathways.	Oleanolic Acid	26-40	interleukin 5	Mus musculus	82-86
24374304-5	2014	The therapeutic effect of oleanolic acid was due to suppression of Th2 cytokines (IL-5 and IL-13), B cell-dependent production of OVA-specific IgE, and Gr-1 expression through the T-bet, GATA-3, retinoic acid-related orphan receptor gamma t (RORgamma t) and forkhead box p3 (Foxp3) transcription pathways.	Oleanolic Acid	26-40	interleukin 13	Mus musculus	91-96
24374304-5	2014	The therapeutic effect of oleanolic acid was due to suppression of Th2 cytokines (IL-5 and IL-13), B cell-dependent production of OVA-specific IgE, and Gr-1 expression through the T-bet, GATA-3, retinoic acid-related orphan receptor gamma t (RORgamma t) and forkhead box p3 (Foxp3) transcription pathways.	Oleanolic Acid	26-40	glutathione reductase	Mus musculus	130-156
24374304-5	2014	The therapeutic effect of oleanolic acid was due to suppression of Th2 cytokines (IL-5 and IL-13), B cell-dependent production of OVA-specific IgE, and Gr-1 expression through the T-bet, GATA-3, retinoic acid-related orphan receptor gamma t (RORgamma t) and forkhead box p3 (Foxp3) transcription pathways.	Oleanolic Acid	26-40	T-box 21	Mus musculus	180-185
24374304-5	2014	The therapeutic effect of oleanolic acid was due to suppression of Th2 cytokines (IL-5 and IL-13), B cell-dependent production of OVA-specific IgE, and Gr-1 expression through the T-bet, GATA-3, retinoic acid-related orphan receptor gamma t (RORgamma t) and forkhead box p3 (Foxp3) transcription pathways.	Oleanolic Acid	26-40	GATA binding protein 3	Mus musculus	187-252
24374304-5	2014	The therapeutic effect of oleanolic acid was due to suppression of Th2 cytokines (IL-5 and IL-13), B cell-dependent production of OVA-specific IgE, and Gr-1 expression through the T-bet, GATA-3, retinoic acid-related orphan receptor gamma t (RORgamma t) and forkhead box p3 (Foxp3) transcription pathways.	Oleanolic Acid	26-40	forkhead box P3	Mus musculus	258-273
24374304-5	2014	The therapeutic effect of oleanolic acid was due to suppression of Th2 cytokines (IL-5 and IL-13), B cell-dependent production of OVA-specific IgE, and Gr-1 expression through the T-bet, GATA-3, retinoic acid-related orphan receptor gamma t (RORgamma t) and forkhead box p3 (Foxp3) transcription pathways.	Oleanolic Acid	26-40	forkhead box P3	Mus musculus	275-280
24374304-6	2014	It is therefore reasonable to suggest that the anti-inflammatory and anti-asthmatic effects of oleanolic acid may be exerted through inhibition of the GATA-3 and RORgammat pathways.	Oleanolic Acid	95-109	GATA binding protein 3	Mus musculus	151-157
24606795-41	2014	Other strategies include the triggering of Nrf2/antioxidant response element (ARE) pathway by triterpenoids (derivatives of oleanolic acid) or by Bacopa monniera, the enhancement of ATP production by carnitine and -lipoic acid.	Oleanolic Acid	124-138	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47
24393202-0	2014	Oleanolic acid attenuates renal fibrosis in mice with unilateral ureteral obstruction via facilitating nuclear translocation of Nrf2.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132
24393202-8	2014	Additionally, significantly less inflammatory cell infiltration, a lower ratio of Bax to Bcl-2 expression, and fewer apoptotic cells on TUNEL staining were observed in the obstructed kidneys of oleanolic acid-treated mice.	Oleanolic Acid	194-208	BCL2-associated X protein	Mus musculus	82-85
24393202-8	2014	Additionally, significantly less inflammatory cell infiltration, a lower ratio of Bax to Bcl-2 expression, and fewer apoptotic cells on TUNEL staining were observed in the obstructed kidneys of oleanolic acid-treated mice.	Oleanolic Acid	194-208	B cell leukemia/lymphoma 2	Mus musculus	89-94
24393202-9	2014	Oleanolic acid increased the expression of nuclear Nrf2, heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and heat shock protein 70, and decreased lipid peroxidation in the obstructed kidney of UUO mice.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-55
24738052-7	2014	Among 200 purified natural compounds examined, corosolic acid (CA) and oleanolic acid (OA), both are categorized in triterpenoid compounds, inhibited macrophage polarization to M2 phenotype by suppressing STAT3 activation.	Oleanolic Acid	71-85	signal transducer and activator of transcription 3	Homo sapiens	205-210
24738052-7	2014	Among 200 purified natural compounds examined, corosolic acid (CA) and oleanolic acid (OA), both are categorized in triterpenoid compounds, inhibited macrophage polarization to M2 phenotype by suppressing STAT3 activation.	Oleanolic Acid	87-89	signal transducer and activator of transcription 3	Homo sapiens	205-210
24393202-9	2014	Oleanolic acid increased the expression of nuclear Nrf2, heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and heat shock protein 70, and decreased lipid peroxidation in the obstructed kidney of UUO mice.	Oleanolic Acid	0-14	heme oxygenase 1	Mus musculus	57-107
24393202-10	2014	There were no changes in the expression of total Nrf2 and Kelch-like ECH-associated protein 1, indicating that oleanolic acid enhanced nuclear translocation of Nrf2.	Oleanolic Acid	111-125	nuclear factor, erythroid derived 2, like 2	Mus musculus	160-164
24393202-11	2014	CONCLUSIONS: These results suggest that oleanolic acid may exert beneficial effects on renal fibrosis by increasing nuclear translocation of Nrf2 and subsequently reducing renal oxidative stress.	Oleanolic Acid	40-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	141-145
24969879-0	2014	p38 MAPK signaling mediates mitochondrial apoptosis in cancer cells induced by oleanolic acid.	Oleanolic Acid	79-93	mitogen-activated protein kinase 14	Homo sapiens	0-3
24969879-0	2014	p38 MAPK signaling mediates mitochondrial apoptosis in cancer cells induced by oleanolic acid.	Oleanolic Acid	79-93	mitogen-activated protein kinase 1	Homo sapiens	4-8
23515934-4	2013	In addition, the cumulative nociceptive response time for intraplantar formalin injection (2nd phase), intrathecal injection of substance P (0.7 mug) or glutamate (20 mug) was diminished by oleanolic acid.	Oleanolic Acid	190-204	tachykinin 1	Mus musculus	128-139
24231102-0	2013	Dietary oleanolic acid mediates circadian clock gene expression in liver independently of diet and animal model but requires apolipoprotein A1.	Oleanolic Acid	8-22	apolipoprotein A-I	Mus musculus	125-142
24231102-6	2013	In Apoe-deficient mice, oleanolic acid intake increased hepatic area occupied by lipid droplets with no change in oxidative stress.	Oleanolic Acid	24-38	apolipoprotein E	Mus musculus	3-7
24231102-10	2013	The core liver clock components Clock-Bmal1 are a target of oleanolic acid in two animal models independently of the diets provided, and this compound requires APOA1-HDL for its hepatic action.	Oleanolic Acid	60-74	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	38-43
24137431-0	2013	Oleanolic acid inhibits proliferation and induces apoptosis in NB4 cells by targeting PML/RARalpha Oleanolic acid (OA), a naturally occurring pentacyclic triterpenoid contained in a variety of plant species, exhibits broad biological properties, including anticancer effects.	Oleanolic Acid	0-14	PML nuclear body scaffold	Homo sapiens	86-89
24137431-0	2013	Oleanolic acid inhibits proliferation and induces apoptosis in NB4 cells by targeting PML/RARalpha Oleanolic acid (OA), a naturally occurring pentacyclic triterpenoid contained in a variety of plant species, exhibits broad biological properties, including anticancer effects.	Oleanolic Acid	99-113	PML nuclear body scaffold	Homo sapiens	86-89
24137431-0	2013	Oleanolic acid inhibits proliferation and induces apoptosis in NB4 cells by targeting PML/RARalpha Oleanolic acid (OA), a naturally occurring pentacyclic triterpenoid contained in a variety of plant species, exhibits broad biological properties, including anticancer effects.	Oleanolic Acid	115-117	PML nuclear body scaffold	Homo sapiens	86-89
24143040-0	2013	Determination of oleanolic acid and ursolic acid in Chinese medicinal plants using HPLC with PAH polymeric C18.	Oleanolic Acid	17-31	Bardet-Biedl syndrome 9	Homo sapiens	107-110
23515934-8	2013	The results indicate that oleanolic acid shows an antinociceptive property in various pain models such as writhing, formalin, substance P and glutamate pain tests.	Oleanolic Acid	26-40	tachykinin 1	Mus musculus	126-137
23603523-0	2013	Oleanolic acid increases plasma ANP levels via an accentuation of cardiac ANP synthesis and secretion in rats.	Oleanolic Acid	0-14	natriuretic peptide A	Rattus norvegicus	32-35
23668350-3	2013	The docking analyses of 10 selected terpenoids along with drugs revealed that all of the terpenoids were more potent inhibitors of COX-1 rather than COX-2 with the oleanolic acid as the most potent inhibitor of COX in general (binding energy [-18.68Kcal/mol and -18.25Kcal/mol] and estimated Ki [5.57x10(-8)microM and 11.4x10(-8)microM] for COX-1 and COX-2, respectively) and beta-carotene as most selective inhibitor of COX-1.	Oleanolic Acid	164-178	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	131-136
23668350-3	2013	The docking analyses of 10 selected terpenoids along with drugs revealed that all of the terpenoids were more potent inhibitors of COX-1 rather than COX-2 with the oleanolic acid as the most potent inhibitor of COX in general (binding energy [-18.68Kcal/mol and -18.25Kcal/mol] and estimated Ki [5.57x10(-8)microM and 11.4x10(-8)microM] for COX-1 and COX-2, respectively) and beta-carotene as most selective inhibitor of COX-1.	Oleanolic Acid	164-178	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
23497885-3	2013	Of the non-flavonoid phytochemicals tested, berberine, celastrol, ellagic acid, limonin, oleanolic acid, propyl gallate, sinapic acid and ursolic acid demonstrated significant inhibition of ABCG2-mediated transport.	Oleanolic Acid	89-103	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	190-195
23603523-0	2013	Oleanolic acid increases plasma ANP levels via an accentuation of cardiac ANP synthesis and secretion in rats.	Oleanolic Acid	0-14	natriuretic peptide A	Rattus norvegicus	74-77
23603523-2	2013	The present study was designed to identify the effects of oleanolic acid on plasma levels and atrial synthesis and secretion of atrial natriuretic peptide (ANP).	Oleanolic Acid	58-72	natriuretic peptide A	Rattus norvegicus	128-154
23603523-2	2013	The present study was designed to identify the effects of oleanolic acid on plasma levels and atrial synthesis and secretion of atrial natriuretic peptide (ANP).	Oleanolic Acid	58-72	natriuretic peptide A	Rattus norvegicus	156-159
23603523-6	2013	Administration of oleanolic acid increased plasma ANP levels in a dose-related manner.	Oleanolic Acid	18-32	natriuretic peptide A	Rattus norvegicus	50-53
23603523-7	2013	Similarly, oleanolic acid increased atrial ANP content and ANP mRNA expression.	Oleanolic Acid	11-25	natriuretic peptide A	Rattus norvegicus	43-46
23603523-7	2013	Similarly, oleanolic acid increased atrial ANP content and ANP mRNA expression.	Oleanolic Acid	11-25	natriuretic peptide A	Rattus norvegicus	59-62
23603523-9	2013	Baseline levels of ANP secretion were higher in the atria from rats treated with oleanolic acid compared to rats treated with vehicle.	Oleanolic Acid	81-95	natriuretic peptide A	Rattus norvegicus	19-22
23603523-10	2013	Furthermore, oleanolic acid treatment enhanced the stretch-induced increase in ANP secretion.	Oleanolic Acid	13-27	natriuretic peptide A	Rattus norvegicus	79-82
23603523-12	2013	The acetylcholine-induced increase in ANP secretion was also enhanced in the atria from rats treated with oleanolic acid compared to atria from rats treated with vehicle.	Oleanolic Acid	106-120	natriuretic peptide A	Rattus norvegicus	38-41
23603523-13	2013	The present findings indicate that oleanolic acid increases plasma ANP levels via increased ANP synthesis and secretion in rats.	Oleanolic Acid	35-49	natriuretic peptide A	Rattus norvegicus	67-70
23603523-13	2013	The present findings indicate that oleanolic acid increases plasma ANP levels via increased ANP synthesis and secretion in rats.	Oleanolic Acid	35-49	natriuretic peptide A	Rattus norvegicus	92-95
23603523-14	2013	It is proposed that an accentuation of the ANP system is involved in the beneficial effects of oleanolic acid on the regulation of cardiovascular homeostasis.	Oleanolic Acid	95-109	natriuretic peptide A	Rattus norvegicus	43-46
23531458-0	2013	Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors.	Oleanolic Acid	39-53	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	69-74
23404993-0	2013	Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis.	Oleanolic Acid	21-35	tumor protein p53	Homo sapiens	72-75
23531458-1	2013	Twenty-four sugar-substituted oleanolic acid derivatives (1a-1f, 2a-2j, and 3a-3h) were synthesized in a concise and efficient strategy and their effects on the inhibition of protein tyrosine phosphatase 1B (PTP1B) and insulin-sensitizing response were evaluated in vitro.	Oleanolic Acid	30-44	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	175-206
23531458-1	2013	Twenty-four sugar-substituted oleanolic acid derivatives (1a-1f, 2a-2j, and 3a-3h) were synthesized in a concise and efficient strategy and their effects on the inhibition of protein tyrosine phosphatase 1B (PTP1B) and insulin-sensitizing response were evaluated in vitro.	Oleanolic Acid	30-44	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	208-213
23531458-1	2013	Twenty-four sugar-substituted oleanolic acid derivatives (1a-1f, 2a-2j, and 3a-3h) were synthesized in a concise and efficient strategy and their effects on the inhibition of protein tyrosine phosphatase 1B (PTP1B) and insulin-sensitizing response were evaluated in vitro.	Oleanolic Acid	30-44	insulin	Homo sapiens	219-226
23531458-4	2013	Structure-activity relationship study of these sugar-substituted oleanolic acid derivatives demonstrated that PTP1B inhibitory activity and insulin-sensitizing response were strongly influenced by both the carbohydrate moiety at the C-3 position and the long acidic chain at C-28 position of oleanolic acid.	Oleanolic Acid	65-79	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	110-115
23531458-4	2013	Structure-activity relationship study of these sugar-substituted oleanolic acid derivatives demonstrated that PTP1B inhibitory activity and insulin-sensitizing response were strongly influenced by both the carbohydrate moiety at the C-3 position and the long acidic chain at C-28 position of oleanolic acid.	Oleanolic Acid	65-79	insulin	Homo sapiens	140-147
23531458-4	2013	Structure-activity relationship study of these sugar-substituted oleanolic acid derivatives demonstrated that PTP1B inhibitory activity and insulin-sensitizing response were strongly influenced by both the carbohydrate moiety at the C-3 position and the long acidic chain at C-28 position of oleanolic acid.	Oleanolic Acid	292-306	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	110-115
23399665-7	2013	When oleanolic acid was supplied to differentiating adipocytes, STAT1 and STAT3 phosphorylation was substantially suppressed.	Oleanolic Acid	5-19	signal transducer and activator of transcription 1	Homo sapiens	64-69
23151611-7	2013	Moreover, BDNF levels in the two brain regions were also elevated by chronic oleanolic acid treatment (frontal cortex: 20 mg/kg, 67.2%; hippocampus: 10 mg/kg, 36.4%; 20 mg/kg, 55.1%).	Oleanolic Acid	77-91	brain derived neurotrophic factor	Mus musculus	10-14
23151611-8	2013	Taken together, these findings imply that functions of 5-HT, NE and BDNF may be involved in the antidepressant-like effect of oleanolic acid.	Oleanolic Acid	126-140	brain derived neurotrophic factor	Mus musculus	68-72
23434227-1	2013	Twelve derivatives of oleanolic acid (1) have been synthesized and evaluated for their inhibitory activities against the growth of prostate PC3, breast MCF-7, lung A549, and gastric BGC-823 cancer cells by MTT assays.	Oleanolic Acid	22-36	chromobox 8	Homo sapiens	140-143
23434227-3	2013	SAR analysis indicates that H-donor substitution at C-3 position of oleanolic acid may be advantageous for improvement of cytotoxicity against PC3, A549 and MCF-7 cell lines.	Oleanolic Acid	68-82	chromobox 8	Homo sapiens	143-146
23275618-3	2013	Treatment of cells with the TGR5-selective ligand oleanolic acid (OA) activated Galphas, but not Galphaq, Galphai1, Galphai2, or Galphai3, and increased cAMP levels.	Oleanolic Acid	50-64	G protein-coupled bile acid receptor 1	Mus musculus	28-32
23275618-3	2013	Treatment of cells with the TGR5-selective ligand oleanolic acid (OA) activated Galphas, but not Galphaq, Galphai1, Galphai2, or Galphai3, and increased cAMP levels.	Oleanolic Acid	50-64	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	116-124
23275618-3	2013	Treatment of cells with the TGR5-selective ligand oleanolic acid (OA) activated Galphas, but not Galphaq, Galphai1, Galphai2, or Galphai3, and increased cAMP levels.	Oleanolic Acid	50-64	guanine nucleotide binding protein (G protein), alpha inhibiting 3	Mus musculus	129-137
23275618-3	2013	Treatment of cells with the TGR5-selective ligand oleanolic acid (OA) activated Galphas, but not Galphaq, Galphai1, Galphai2, or Galphai3, and increased cAMP levels.	Oleanolic Acid	50-64	cathelicidin antimicrobial peptide	Mus musculus	153-157
23339520-0	2013	Propylene glycol-linked amino acid/dipeptide diester prodrugs of oleanolic acid for PepT1-mediated transport: synthesis, intestinal permeability, and pharmacokinetics.	Oleanolic Acid	65-79	solute carrier family 15 member 1	Rattus norvegicus	84-89
23339520-1	2013	In our previous studies, ethylene glycol-linked amino acid diester prodrugs of oleanolic acid (OA), a Biopharmaceutics Classification System (BCS) class IV drug, designed to target peptide transporter 1 (PepT1) have been synthesized and evaluated.	Oleanolic Acid	79-93	solute carrier family 15 member 1	Rattus norvegicus	181-202
23339520-1	2013	In our previous studies, ethylene glycol-linked amino acid diester prodrugs of oleanolic acid (OA), a Biopharmaceutics Classification System (BCS) class IV drug, designed to target peptide transporter 1 (PepT1) have been synthesized and evaluated.	Oleanolic Acid	79-93	solute carrier family 15 member 1	Rattus norvegicus	204-209
23399665-7	2013	When oleanolic acid was supplied to differentiating adipocytes, STAT1 and STAT3 phosphorylation was substantially suppressed.	Oleanolic Acid	5-19	signal transducer and activator of transcription 3	Homo sapiens	74-79
23399665-8	2013	Upstream Tyk2 was rapidly activated in a manner similar to STAT3 and reactivated on days 3 to 5 after initiating differentiation, which was attenuated by incubating adipocytes with oleanolic acid.	Oleanolic Acid	181-195	tyrosine kinase 2	Homo sapiens	9-13
23399665-10	2013	Oleanolic acid attenuated SOCS3 expression, which was highly enhanced during the late phase of differentiation.	Oleanolic Acid	0-14	suppressor of cytokine signaling 3	Homo sapiens	26-31
23399665-11	2013	Taken together, oleanolic acid suppressed adipocyte differentiation-associated resistin and adipogenesis production by disturbing the Tyk2-STAT1/3 signaling pathway and promoting SOCS3 expression.	Oleanolic Acid	16-30	tyrosine kinase 2	Homo sapiens	134-138
23399665-11	2013	Taken together, oleanolic acid suppressed adipocyte differentiation-associated resistin and adipogenesis production by disturbing the Tyk2-STAT1/3 signaling pathway and promoting SOCS3 expression.	Oleanolic Acid	16-30	signal transducer and activator of transcription 1	Homo sapiens	139-144
23399665-11	2013	Taken together, oleanolic acid suppressed adipocyte differentiation-associated resistin and adipogenesis production by disturbing the Tyk2-STAT1/3 signaling pathway and promoting SOCS3 expression.	Oleanolic Acid	16-30	suppressor of cytokine signaling 3	Homo sapiens	179-184
23041323-6	2013	Application of deoxycholic acid, lithocholic acid, or oleanolic acid (a selective agonist of TGR5) to the mucosa of tgr5-wt mice caused oral contraction and caudal relaxation, indicating peristalsis.	Oleanolic Acid	54-68	G protein-coupled bile acid receptor 1	Mus musculus	93-97
23548129-8	2013	Chemical characterization from HPLC indicated that EA-ACE contains betulinic acid, ursolic acid and oleanolic acid.	Oleanolic Acid	100-114	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	54-57
23041323-6	2013	Application of deoxycholic acid, lithocholic acid, or oleanolic acid (a selective agonist of TGR5) to the mucosa of tgr5-wt mice caused oral contraction and caudal relaxation, indicating peristalsis.	Oleanolic Acid	54-68	G protein-coupled bile acid receptor 1	Mus musculus	116-120
23489687-0	2013	Protective effect of oleanolic acid against beta cell dysfunction and mitochondrial apoptosis: crucial role of ERK-NRF2 signaling pathway.	Oleanolic Acid	21-35	mitogen-activated protein kinase 1	Mus musculus	111-114
24009420-10	2013	Aspartate and alanine aminotransferase levels were significantly lower on exposure to NLCs loaded with both oleanolic acid and gentiopicrin than in negative controls.	Oleanolic Acid	108-122	glutamic--pyruvic transaminase	Homo sapiens	14-38
23489687-0	2013	Protective effect of oleanolic acid against beta cell dysfunction and mitochondrial apoptosis: crucial role of ERK-NRF2 signaling pathway.	Oleanolic Acid	21-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
22799301-7	2012	The IC50 values achieved for maslinic acid, staurosporine, H-7, sphingosine, rottlerin, ursolic acid and oleanolic acid were 11.52, 0.011, 0.767, 2.45, 5.46, 27.93 and 39.29 muM, respectively.	Oleanolic Acid	105-119	latexin	Homo sapiens	174-177
22352697-0	2012	Ethylene glycol-linked amino acid diester prodrugs of oleanolic acid for PepT1-mediated transport: synthesis, intestinal permeability and pharmacokinetics.	Oleanolic Acid	54-68	solute carrier family 15 member 1	Rattus norvegicus	73-78
22352697-1	2012	The purposes of this study were to expand the structure of parent drugs selected for peptide transporter 1 (PepT1)-targeted ester prodrug design and to improve oral bioavailability of oleanolic acid (OA), a Biopharmaceutics Classification System (BCS) class IV drug.	Oleanolic Acid	184-198	solute carrier family 15 member 1	Rattus norvegicus	108-113
23236829-0	2012	[The anti-portal hypertension effect of oleanolic acid in CCl4-induced cirrhosis rats].	Oleanolic Acid	40-54	C-C motif chemokine ligand 4	Rattus norvegicus	58-62
23236829-1	2012	OBJECTIVE: To study the anti-portal hypertension effect of oleanolic acid (OA) in CCl4-induced cirrhosis rats and its mechanism.	Oleanolic Acid	59-73	C-C motif chemokine ligand 4	Rattus norvegicus	82-86
23236829-1	2012	OBJECTIVE: To study the anti-portal hypertension effect of oleanolic acid (OA) in CCl4-induced cirrhosis rats and its mechanism.	Oleanolic Acid	75-77	C-C motif chemokine ligand 4	Rattus norvegicus	82-86
22386814-0	2012	Anti-inflammatory activities of oleanolic acid on HMGB1 activated HUVECs.	Oleanolic Acid	32-46	high mobility group box 1	Homo sapiens	50-55
22386814-3	2012	Oleanolic acid (OA), a triterpenoid known for its anti-inflammatory and anti-cancer properties, is commonly present in several medicinal plants but the effects of OA on HMGB1-mediated pro-inflammatory responses of human endothelial cells is not well-studied.	Oleanolic Acid	0-14	high mobility group box 1	Homo sapiens	169-174
22178681-4	2012	The five oleanolic acid triterpenoid saponins used in this experiment suppressed N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation in a concentration-dependent manner.	Oleanolic Acid	9-23	formyl peptide receptor 1	Homo sapiens	122-126
23387077-0	2012	[Oleanolic acid inhibits proliferation of HUVECs, and inhibits migration and tube formation via VEGF pathway].	Oleanolic Acid	1-15	vascular endothelial growth factor A	Homo sapiens	96-100
22213398-8	2012	Finally, we isolated ursolic and oleanolic acids as the bioactive compounds able to upregulate p53 expression and inhibit breast cancer cell growth.	Oleanolic Acid	33-48	tumor protein p53	Homo sapiens	95-98
22683839-10	2012	Oleanolic acid intake at 0.1% and 0.2% suppressed NF-kappaB p65, Bax and cleaved caspase-3 production, and retained Bcl-2 expression (P<0.05).	Oleanolic Acid	0-14	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	60-63
22683839-10	2012	Oleanolic acid intake at 0.1% and 0.2% suppressed NF-kappaB p65, Bax and cleaved caspase-3 production, and retained Bcl-2 expression (P<0.05).	Oleanolic Acid	0-14	BCL2-associated X protein	Mus musculus	65-68
22683839-10	2012	Oleanolic acid intake at 0.1% and 0.2% suppressed NF-kappaB p65, Bax and cleaved caspase-3 production, and retained Bcl-2 expression (P<0.05).	Oleanolic Acid	0-14	B cell leukemia/lymphoma 2	Mus musculus	116-121
22154965-12	2012	In addition, carnosol and ursolic acid/oleanolic acid contained in this plant appears to contribute for the antinociceptive property of the extract, possibly through a modulatory influence on TRPA1-receptors.	Oleanolic Acid	39-53	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	192-197
21846839-5	2011	We isolated three compounds, ursolic acid, oleanolic acid, and 8-trans-p-coumaroyloxy-alpha-terpineol, which inhibited estradiol-17beta-glucuronide uptake by OATP1B1 but not OATP1B3.	Oleanolic Acid	43-57	solute carrier organic anion transporter family member 1B1	Homo sapiens	158-165
22860063-0	2012	Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice.	Oleanolic Acid	0-14	thymoma viral proto-oncogene 1	Mus musculus	66-69
22860063-0	2012	Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice.	Oleanolic Acid	0-14	forkhead box O1	Mus musculus	70-75
21958874-0	2011	Antiatherogenic effects of oleanolic acid in apolipoprotein E knockout mice.	Oleanolic Acid	27-41	apolipoprotein E	Mus musculus	45-61
22312713-2	2011	Oleanolic acid, one of the most known triterpenes, was subjected to different chemical transformations within C-3 beta-hydroxyl group, a double bond between C-12 and C-13, and a carboxyl function at C-17 in order to obtain new derivatives.	Oleanolic Acid	0-14	homeobox C13	Homo sapiens	166-170
22312713-2	2011	Oleanolic acid, one of the most known triterpenes, was subjected to different chemical transformations within C-3 beta-hydroxyl group, a double bond between C-12 and C-13, and a carboxyl function at C-17 in order to obtain new derivatives.	Oleanolic Acid	0-14	cytokine like 1	Homo sapiens	199-203
21922144-0	2011	Oleanolic acid inhibits macrophage differentiation into the M2 phenotype             and glioblastoma cell proliferation by suppressing the activation of STAT3.	Oleanolic Acid	0-14	signal transducer and activator of transcription 3	Homo sapiens	154-159
21846839-5	2011	We isolated three compounds, ursolic acid, oleanolic acid, and 8-trans-p-coumaroyloxy-alpha-terpineol, which inhibited estradiol-17beta-glucuronide uptake by OATP1B1 but not OATP1B3.	Oleanolic Acid	43-57	solute carrier organic anion transporter family member 1B3	Homo sapiens	174-181
21328610-0	2011	PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase-1 expression in rat vascular smooth muscle cells.	Oleanolic Acid	43-57	Eph receptor B1	Rattus norvegicus	9-12
21328610-0	2011	PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase-1 expression in rat vascular smooth muscle cells.	Oleanolic Acid	43-57	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17
21328610-0	2011	PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase-1 expression in rat vascular smooth muscle cells.	Oleanolic Acid	43-57	heme oxygenase 1	Rattus norvegicus	66-82
21328610-1	2011	Oleanolic acid (OA), a widely used plant-derived triterpenoid, has been shown to possess potent antiatherosclerotic effects, which may be associated with the induction of heme oxygenase-1 (HO-1).	Oleanolic Acid	0-14	heme oxygenase 1	Rattus norvegicus	171-187
21328610-1	2011	Oleanolic acid (OA), a widely used plant-derived triterpenoid, has been shown to possess potent antiatherosclerotic effects, which may be associated with the induction of heme oxygenase-1 (HO-1).	Oleanolic Acid	0-14	heme oxygenase 1	Rattus norvegicus	189-193
21561086-4	2011	Among them, oleanolic acid (1) was found to be the most potent competitive inhibitor (inhibition constant, 72 nM) with the highest AKR1B10/AKR1B1 selectivity ratio of 1370.	Oleanolic Acid	12-26	aldo-keto reductase family 1 member B10	Homo sapiens	131-138
21246613-0	2011	Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells.	Oleanolic Acid	32-46	mechanistic target of rapamycin kinase	Homo sapiens	14-18
21561086-4	2011	Among them, oleanolic acid (1) was found to be the most potent competitive inhibitor (inhibition constant, 72 nM) with the highest AKR1B10/AKR1B1 selectivity ratio of 1370.	Oleanolic Acid	12-26	aldo-keto reductase family 1 member B	Homo sapiens	131-137
21561086-6	2011	Oleanolic acid (1) also inhibited the cellular metabolism by AKR1B10 (IC(50), 4 muM) and decreased mitomycin C tolerance of colon cancer HT29 cells.	Oleanolic Acid	0-14	aldo-keto reductase family 1 member B10	Homo sapiens	61-68
21561086-6	2011	Oleanolic acid (1) also inhibited the cellular metabolism by AKR1B10 (IC(50), 4 muM) and decreased mitomycin C tolerance of colon cancer HT29 cells.	Oleanolic Acid	0-14	latexin	Homo sapiens	80-83
21169016-3	2011	The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs.	Oleanolic Acid	163-177	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	90-94
21442679-3	2011	In this study, the effects of oleanolic acid and ursolic acid on MUC5AC mucin production and gene expression induced by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) from human airway epithelial cells were investigated.	Oleanolic Acid	30-44	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	65-71
21442679-3	2011	In this study, the effects of oleanolic acid and ursolic acid on MUC5AC mucin production and gene expression induced by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) from human airway epithelial cells were investigated.	Oleanolic Acid	30-44	LOC100508689	Homo sapiens	72-77
21442679-6	2011	Oleanolic acid and ursolic acid were found to inhibit the production of MUC5AC mucin protein induced by EGF and PMA, and both compounds also inhibited the expression of MUC5AC mucin gene induced by EGF and PMA.	Oleanolic Acid	0-14	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	72-78
21442679-6	2011	Oleanolic acid and ursolic acid were found to inhibit the production of MUC5AC mucin protein induced by EGF and PMA, and both compounds also inhibited the expression of MUC5AC mucin gene induced by EGF and PMA.	Oleanolic Acid	0-14	LOC100508689	Homo sapiens	79-84
21442679-6	2011	Oleanolic acid and ursolic acid were found to inhibit the production of MUC5AC mucin protein induced by EGF and PMA, and both compounds also inhibited the expression of MUC5AC mucin gene induced by EGF and PMA.	Oleanolic Acid	0-14	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	169-175
21442679-6	2011	Oleanolic acid and ursolic acid were found to inhibit the production of MUC5AC mucin protein induced by EGF and PMA, and both compounds also inhibited the expression of MUC5AC mucin gene induced by EGF and PMA.	Oleanolic Acid	0-14	LOC100508689	Homo sapiens	176-181
21442679-7	2011	These results suggest that oleanolic acid and ursolic acid can regulate mucin gene expression, and production of mucin protein, by directly acting on airway epithelial cells.	Oleanolic Acid	27-41	LOC100508689	Homo sapiens	72-77
21442679-7	2011	These results suggest that oleanolic acid and ursolic acid can regulate mucin gene expression, and production of mucin protein, by directly acting on airway epithelial cells.	Oleanolic Acid	27-41	LOC100508689	Homo sapiens	113-118
19943081-3	2011	The effect of dextrose-oleanolic acid (the most potent oleanolic acid derivative) on apoptosis of osteosarcoma cells was evaluated using the Annexin-V method.	Oleanolic Acid	23-37	annexin A5	Mus musculus	141-150
21518490-10	2011	It is concluded that up-regulation of PTEN mRNA and PTEN protein may be involved in oleanolic acid-induced Jurkat cell apoptosis.	Oleanolic Acid	84-98	phosphatase and tensin homolog	Homo sapiens	52-56
20632303-6	2011	Further studies revealed that only oleanolic acid and ursolic acid, but not betulinic acid, could inhibit the lipopolysaccharide induced interleukin-6 release from Mono Mac 6 cells when tested separately.	Oleanolic Acid	35-49	interleukin 6	Homo sapiens	137-150
21542298-0	2011	[Determination of protein binding rate of oleanolic acid in human plasma and serum albumin].	Oleanolic Acid	42-56	albumin	Homo sapiens	83-90
21542298-1	2011	A LC-MS method was established for the determination of the protein binding rates of oleanolic acid in human plasma and serum albumin.	Oleanolic Acid	85-99	albumin	Homo sapiens	126-133
21542298-4	2011	The human serum albumin protein binding rates of oleanolic acid at three concentrations were 53.5%, 56.6% and 47.7%, respectively.	Oleanolic Acid	49-63	albumin	Homo sapiens	10-23
21518490-0	2011	[Effects of oleanolic acid on apoptosis and PTEN expression of Jurkat cells].	Oleanolic Acid	12-26	phosphatase and tensin homolog	Homo sapiens	44-48
21518490-1	2011	This study was aimed to explore the effects of oleanolic acid on PTEN expression and apoptosis of Jurkat cells.	Oleanolic Acid	47-61	phosphatase and tensin homolog	Homo sapiens	65-69
21518490-9	2011	PTEN mRNA and protein expressions were up-regulated in Jurkat cells treated with oleanolic acid of concentration 80 micromol/L and 160 micromol/L for 24 hours.	Oleanolic Acid	81-95	phosphatase and tensin homolog	Homo sapiens	0-4
21518490-10	2011	It is concluded that up-regulation of PTEN mRNA and PTEN protein may be involved in oleanolic acid-induced Jurkat cell apoptosis.	Oleanolic Acid	84-98	phosphatase and tensin homolog	Homo sapiens	38-42
21169016-3	2011	The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs.	Oleanolic Acid	163-177	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	148-152
21804254-0	2011	Synthesis of new alpha-glucosidase inhibitors based on oleanolic acid incorporating cinnamic amides.	Oleanolic Acid	55-69	sucrase-isomaltase	Homo sapiens	17-34
21804254-1	2011	A series of alpha-glucosidase inhibitors with the oleanolic acid core and different cinnamic amide ligands were designed and synthesized.	Oleanolic Acid	50-64	sucrase-isomaltase	Homo sapiens	12-29
22358098-0	2011	Oleanolic acid derivative methyl 3,11-dioxoolean-12-en-28-olate targets multidrug resistance related to ABCB1.	Oleanolic Acid	0-14	ATP binding cassette subfamily B member 1	Homo sapiens	104-109
21609313-4	2011	The apoptotic genes p53, BAX, caspase-9, and caspase-3 were found upregulated in oleanolic acid-treated cells, whereas the antiapoptotic gene Bcl-2 was downregulated.	Oleanolic Acid	81-95	B cell leukemia/lymphoma 2	Mus musculus	142-147
21609313-0	2011	Oleanolic acid induces apoptosis by modulating p53, Bax, Bcl-2 and caspase-3 gene expression and regulates the activation of transcription factors and cytokine profile in B16F.	Oleanolic Acid	0-14	transformation related protein 53, pseudogene	Mus musculus	47-50
21609313-0	2011	Oleanolic acid induces apoptosis by modulating p53, Bax, Bcl-2 and caspase-3 gene expression and regulates the activation of transcription factors and cytokine profile in B16F.	Oleanolic Acid	0-14	BCL2-associated X protein	Mus musculus	52-55
21609313-0	2011	Oleanolic acid induces apoptosis by modulating p53, Bax, Bcl-2 and caspase-3 gene expression and regulates the activation of transcription factors and cytokine profile in B16F.	Oleanolic Acid	0-14	B cell leukemia/lymphoma 2	Mus musculus	57-62
21609313-0	2011	Oleanolic acid induces apoptosis by modulating p53, Bax, Bcl-2 and caspase-3 gene expression and regulates the activation of transcription factors and cytokine profile in B16F.	Oleanolic Acid	0-14	caspase 3	Mus musculus	67-76
21609313-4	2011	The apoptotic genes p53, BAX, caspase-9, and caspase-3 were found upregulated in oleanolic acid-treated cells, whereas the antiapoptotic gene Bcl-2 was downregulated.	Oleanolic Acid	81-95	transformation related protein 53, pseudogene	Mus musculus	20-23
21609313-4	2011	The apoptotic genes p53, BAX, caspase-9, and caspase-3 were found upregulated in oleanolic acid-treated cells, whereas the antiapoptotic gene Bcl-2 was downregulated.	Oleanolic Acid	81-95	BCL2-associated X protein	Mus musculus	25-28
21609313-4	2011	The apoptotic genes p53, BAX, caspase-9, and caspase-3 were found upregulated in oleanolic acid-treated cells, whereas the antiapoptotic gene Bcl-2 was downregulated.	Oleanolic Acid	81-95	caspase 9	Mus musculus	30-39
21609313-4	2011	The apoptotic genes p53, BAX, caspase-9, and caspase-3 were found upregulated in oleanolic acid-treated cells, whereas the antiapoptotic gene Bcl-2 was downregulated.	Oleanolic Acid	81-95	caspase 3	Mus musculus	45-54
22358098-2	2011	In a search for potential multidrug resistance modulators we tested a group of oleanolic acid (OA) analogues modified at C-3, C-11, C-12 and C-28 using an experimental model consisting of three human acute lymphoblastic leukemia cell lines (CCRF-CEM and the multidrug resistant sublines CCRF-VCR1000 and CCRF-ADR5000).	Oleanolic Acid	95-97	RNA polymerase III subunit K	Homo sapiens	126-130
22046243-9	2011	Treating mice rendered colitic by TNBS with ciprofloxacin and oleanolic acid, a well characterized GP-BAR1 ligand, abrogates signs and symptoms of colitis.	Oleanolic Acid	62-76	G protein-coupled bile acid receptor 1	Mus musculus	99-106
21147366-3	2010	This study tested the hypothesis that oleanolic acid suppresses the differentiation of 3T3-L1 adipocytes by downregulating cellular induction of peroxisome proliferators-activated receptor gamma (PPARgamma) and cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT) enhancer binding protein alpha (C/EBPalpha).	Oleanolic Acid	38-52	peroxisome proliferator activated receptor gamma	Homo sapiens	145-194
20579861-2	2010	We examined the effects of two pentacyclic triterpenoid acids, ursolic acid (UA) and oleanolic acid (OA), on the expression of E-selectin by cultured human umbilical vein endothelial cells (HUVECs).	Oleanolic Acid	85-99	selectin E	Homo sapiens	127-137
20579861-2	2010	We examined the effects of two pentacyclic triterpenoid acids, ursolic acid (UA) and oleanolic acid (OA), on the expression of E-selectin by cultured human umbilical vein endothelial cells (HUVECs).	Oleanolic Acid	101-103	selectin E	Homo sapiens	127-137
20964318-0	2010	Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.	Oleanolic Acid	39-53	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	83-114
20964318-2	2010	Derivatives of oleanolic acid were synthesized and evaluated as PTP1B inhibitors.	Oleanolic Acid	15-29	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	64-69
22355716-3	2011	Derivatives of the natural triterpene oleanolic acid, namely CDDO-trifluoroethyl-amide (CDDO-TFEA), completely suppressed disease in a murine model of MS, experimental autoimmune encephalomyelitis (EAE), by inhibiting Th1 and Th17 mRNA and cytokine production.	Oleanolic Acid	38-52	negative elongation factor complex member C/D, Th1l	Mus musculus	218-221
20579861-0	2010	Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-alpha-induced E-selectin expression by cultured umbilical vein endothelial cells.	Oleanolic Acid	17-31	tumor necrosis factor	Homo sapiens	85-94
20579861-0	2010	Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-alpha-induced E-selectin expression by cultured umbilical vein endothelial cells.	Oleanolic Acid	17-31	selectin E	Homo sapiens	103-113
21147366-3	2010	This study tested the hypothesis that oleanolic acid suppresses the differentiation of 3T3-L1 adipocytes by downregulating cellular induction of peroxisome proliferators-activated receptor gamma (PPARgamma) and cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT) enhancer binding protein alpha (C/EBPalpha).	Oleanolic Acid	38-52	peroxisome proliferator activated receptor gamma	Homo sapiens	196-205
21147366-3	2010	This study tested the hypothesis that oleanolic acid suppresses the differentiation of 3T3-L1 adipocytes by downregulating cellular induction of peroxisome proliferators-activated receptor gamma (PPARgamma) and cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT) enhancer binding protein alpha (C/EBPalpha).	Oleanolic Acid	38-52	CCAAT enhancer binding protein alpha	Homo sapiens	211-297
21147366-3	2010	This study tested the hypothesis that oleanolic acid suppresses the differentiation of 3T3-L1 adipocytes by downregulating cellular induction of peroxisome proliferators-activated receptor gamma (PPARgamma) and cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT) enhancer binding protein alpha (C/EBPalpha).	Oleanolic Acid	38-52	CCAAT enhancer binding protein alpha	Homo sapiens	299-309
21147366-6	2010	Western blot analysis showed that the induction of PPARgamma and C/EBPalpha was markedly attenuated in differentiated and oleanolic acid-treated adipocytes at their transcriptional messenger RNA levels.	Oleanolic Acid	122-136	peroxisome proliferator activated receptor gamma	Homo sapiens	51-60
21147366-6	2010	Western blot analysis showed that the induction of PPARgamma and C/EBPalpha was markedly attenuated in differentiated and oleanolic acid-treated adipocytes at their transcriptional messenger RNA levels.	Oleanolic Acid	122-136	CCAAT enhancer binding protein alpha	Homo sapiens	65-75
21147366-7	2010	Furthermore, this study examined whether oleanolic acid dampened the induction of visfatin, a proinflammatory and visceral fat-specific adipokine expressed in adipocytes.	Oleanolic Acid	41-55	nicotinamide phosphoribosyltransferase	Homo sapiens	82-90
21147366-9	2010	In addition, the visfatin production was significantly repressed in 25 mumol/L oleanolic acid-treated adipocytes, possibly through blocking PPARgamma activation.	Oleanolic Acid	79-93	nicotinamide phosphoribosyltransferase	Homo sapiens	17-25
21147366-9	2010	In addition, the visfatin production was significantly repressed in 25 mumol/L oleanolic acid-treated adipocytes, possibly through blocking PPARgamma activation.	Oleanolic Acid	79-93	peroxisome proliferator activated receptor gamma	Homo sapiens	140-149
20415421-0	2010	Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP.	Oleanolic Acid	0-14	MIR7-3 host gene	Homo sapiens	52-56
20027631-0	2010	Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid.	Oleanolic Acid	126-140	CREB regulated transcription coactivator 1	Mus musculus	36-42
20027631-0	2010	Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid.	Oleanolic Acid	126-140	CREB regulated transcription coactivator 2	Mus musculus	47-53
20027631-0	2010	Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid.	Oleanolic Acid	126-140	estrogen receptor 1	Homo sapiens	66-83
21588427-1	2010	The title terpene, C(30)H(46)O(3), is a 28,13beta-lactone of oleanolic acid prepared with bis-muth trifluoro-methane-sulfonate (OTf), Bi(OTf)(3) xH(2)O.	Oleanolic Acid	61-75	POU class 5 homeobox 1	Homo sapiens	134-143
20415421-0	2010	Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP.	Oleanolic Acid	0-14	X-linked inhibitor of apoptosis	Homo sapiens	158-162
20171069-2	2010	As measured by HPLC, Cyracos contains significant amounts of rosmarinic acid and the triterpenoids oleanolic acid and ursolic acid, which inhibit gamma-aminobutyric acid transaminase (GABA-T) activity and increase GABA levels in the brain (Awad et al., 2007; Awad et al., 2009).	Oleanolic Acid	99-113	4-aminobutyrate aminotransferase	Mus musculus	146-182
20171069-2	2010	As measured by HPLC, Cyracos contains significant amounts of rosmarinic acid and the triterpenoids oleanolic acid and ursolic acid, which inhibit gamma-aminobutyric acid transaminase (GABA-T) activity and increase GABA levels in the brain (Awad et al., 2007; Awad et al., 2009).	Oleanolic Acid	99-113	4-aminobutyrate aminotransferase	Mus musculus	184-190
20100471-0	2010	Antioxidant activities of oleanolic acid in vitro: possible role of Nrf2 and MAP kinases.	Oleanolic Acid	26-40	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
19917277-1	2010	Inhibitory effects of oleanolic acid (OA) and ursolic acid (UA) on aldose reductase (AR) and glycative products in kidney of diabetic mice were examined.	Oleanolic Acid	22-36	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	67-83
19653193-0	2010	Oleanolic acid is a selective farnesoid X receptor modulator.	Oleanolic Acid	0-14	nuclear receptor subfamily 1 group H member 4	Homo sapiens	30-50
19917277-1	2010	Inhibitory effects of oleanolic acid (OA) and ursolic acid (UA) on aldose reductase (AR) and glycative products in kidney of diabetic mice were examined.	Oleanolic Acid	22-36	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	85-87
19917277-1	2010	Inhibitory effects of oleanolic acid (OA) and ursolic acid (UA) on aldose reductase (AR) and glycative products in kidney of diabetic mice were examined.	Oleanolic Acid	38-40	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	67-83
19917277-1	2010	Inhibitory effects of oleanolic acid (OA) and ursolic acid (UA) on aldose reductase (AR) and glycative products in kidney of diabetic mice were examined.	Oleanolic Acid	38-40	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	85-87
19763045-7	2009	Oleanolic acid isolated from A. cordata also inhibited neuronal death, elevation of [Ca(2+)](i), glutamate release, and generation of ROS induced by Abeta(25-35) in cultured rat cortical neurons, suggesting that the neuroprotective effect of A. cordata may be, at least in part, attributable to this compound.	Oleanolic Acid	0-14	amyloid beta (A4) precursor protein	Mus musculus	149-154
20390739-0	2010	Synthesis and alpha-glucosidase inhibitory activity of oleanolic acid derivatives.	Oleanolic Acid	55-69	sucrase-isomaltase	Homo sapiens	14-31
19360320-0	2009	Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb.	Oleanolic Acid	61-75	high mobility group box 1	Mus musculus	13-18
19360320-8	2009	The inhibitory effect on HMGB1 release was enhanced by authentic oleanolic acid (OA), a naturally occurring triterpenoid.	Oleanolic Acid	65-79	high mobility group box 1	Mus musculus	25-30
19360320-8	2009	The inhibitory effect on HMGB1 release was enhanced by authentic oleanolic acid (OA), a naturally occurring triterpenoid.	Oleanolic Acid	81-83	high mobility group box 1	Mus musculus	25-30
18778688-2	2008	Here we identified a new oleanolic acid derivative, 3-beta-(2-carboxybenzoyloxy)-oleanolic acid (NPLC441), which functioned as a competitive PTP1B inhibitor and enhanced insulin-stimulated phosphorylation of IR and AKT in HepG2 cells.	Oleanolic Acid	25-39	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	141-146
19283895-0	2009	Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	25-29
19283895-0	2009	Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-85
19283895-0	2009	Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-85
19283895-2	2009	In order to determine whether oleanolic acid activates nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor known to induce various antioxidant and cytoprotective genes, wild-type and Nrf2-null mice were treated with oleanolic acid (90 mg/kg, i.p.)	Oleanolic Acid	30-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-98
19283895-2	2009	In order to determine whether oleanolic acid activates nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor known to induce various antioxidant and cytoprotective genes, wild-type and Nrf2-null mice were treated with oleanolic acid (90 mg/kg, i.p.)	Oleanolic Acid	30-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	100-104
19283895-4	2009	Oleanolic acid increased nuclear accumulation of Nrf2 in wild-type but not Nrf2-null mice, as determined by Western blot and immunofluorescence.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
19283895-5	2009	Oleanolic acid-treated wild-type mice had increased hepatic mRNA expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1 (Nqo1); glutamate-cysteine ligase, catalytic subunit (Gclc); heme oxygenase-1 (Ho-1); as well as Nrf2 itself.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
19283895-5	2009	Oleanolic acid-treated wild-type mice had increased hepatic mRNA expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1 (Nqo1); glutamate-cysteine ligase, catalytic subunit (Gclc); heme oxygenase-1 (Ho-1); as well as Nrf2 itself.	Oleanolic Acid	0-14	NAD(P)H dehydrogenase, quinone 1	Mus musculus	101-133
19283895-5	2009	Oleanolic acid-treated wild-type mice had increased hepatic mRNA expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1 (Nqo1); glutamate-cysteine ligase, catalytic subunit (Gclc); heme oxygenase-1 (Ho-1); as well as Nrf2 itself.	Oleanolic Acid	0-14	NAD(P)H dehydrogenase, quinone 1	Mus musculus	135-139
19283895-5	2009	Oleanolic acid-treated wild-type mice had increased hepatic mRNA expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1 (Nqo1); glutamate-cysteine ligase, catalytic subunit (Gclc); heme oxygenase-1 (Ho-1); as well as Nrf2 itself.	Oleanolic Acid	0-14	glutamate-cysteine ligase, catalytic subunit	Mus musculus	142-186
19283895-5	2009	Oleanolic acid-treated wild-type mice had increased hepatic mRNA expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1 (Nqo1); glutamate-cysteine ligase, catalytic subunit (Gclc); heme oxygenase-1 (Ho-1); as well as Nrf2 itself.	Oleanolic Acid	0-14	glutamate-cysteine ligase, catalytic subunit	Mus musculus	188-192
19283895-5	2009	Oleanolic acid-treated wild-type mice had increased hepatic mRNA expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1 (Nqo1); glutamate-cysteine ligase, catalytic subunit (Gclc); heme oxygenase-1 (Ho-1); as well as Nrf2 itself.	Oleanolic Acid	0-14	heme oxygenase 1	Mus musculus	195-211
19283895-5	2009	Oleanolic acid-treated wild-type mice had increased hepatic mRNA expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1 (Nqo1); glutamate-cysteine ligase, catalytic subunit (Gclc); heme oxygenase-1 (Ho-1); as well as Nrf2 itself.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	231-235
19283895-6	2009	In addition, oleanolic acid increased protein expression and enzyme activity of the prototypical Nrf2 target gene, Nqo1, in wild-type, but not in Nrf2-null mice.	Oleanolic Acid	13-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-101
19283895-6	2009	In addition, oleanolic acid increased protein expression and enzyme activity of the prototypical Nrf2 target gene, Nqo1, in wild-type, but not in Nrf2-null mice.	Oleanolic Acid	13-27	NAD(P)H dehydrogenase, quinone 1	Mus musculus	115-119
19283895-7	2009	Oleanolic acid protected against acetaminophen hepatotoxicity in wild-type mice but to a lesser extent in Nrf2-null mice.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-110
19283895-8	2009	Oleanolic acid-mediated Nrf2-independent protection from acetaminophen is, in part, due to induction of Nrf2-independent cytoprotective genes, such as metallothionein.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	24-28
19283895-8	2009	Oleanolic acid-mediated Nrf2-independent protection from acetaminophen is, in part, due to induction of Nrf2-independent cytoprotective genes, such as metallothionein.	Oleanolic Acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
19283895-9	2009	Collectively, the present study demonstrates that oleanolic acid facilitates Nrf2 nuclear accumulation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity.	Oleanolic Acid	50-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
19283895-9	2009	Collectively, the present study demonstrates that oleanolic acid facilitates Nrf2 nuclear accumulation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity.	Oleanolic Acid	50-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-129
18778688-2	2008	Here we identified a new oleanolic acid derivative, 3-beta-(2-carboxybenzoyloxy)-oleanolic acid (NPLC441), which functioned as a competitive PTP1B inhibitor and enhanced insulin-stimulated phosphorylation of IR and AKT in HepG2 cells.	Oleanolic Acid	25-39	insulin	Homo sapiens	170-177
18778688-2	2008	Here we identified a new oleanolic acid derivative, 3-beta-(2-carboxybenzoyloxy)-oleanolic acid (NPLC441), which functioned as a competitive PTP1B inhibitor and enhanced insulin-stimulated phosphorylation of IR and AKT in HepG2 cells.	Oleanolic Acid	25-39	AKT serine/threonine kinase 1	Homo sapiens	215-218
19051345-6	2008	Analysis of the anti-inflammatory effects of ursolic acid and oleanolic acid, the triterpene compounds present in PPY, showed that ursolic acid significantly inhibited LPS-induced IL-8 production, NF-kappaB activation, and iNOS mRNA expression, whereas oleanolic acid did not have these effects.	Oleanolic Acid	62-76	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
18415855-0	2008	Microbial transformation of oleanolic acid by Fusarium lini and alpha-glucosidase inhibitory activity of its transformed products.	Oleanolic Acid	28-42	sucrase-isomaltase	Homo sapiens	64-81
18706400-0	2008	New insights into generalized hepatoprotective effects of oleanolic acid: key roles of metallothionein and Nrf2 induction.	Oleanolic Acid	58-72	nuclear factor, erythroid derived 2, like 2	Mus musculus	107-111
18364241-2	2008	Oleanolic acid significantly enhanced insulin secretion at basal and stimulatory glucose concentrations in INS-1 832/13 cells and enhanced acute glucose-stimulated insulin secretion in isolated rat islets.	Oleanolic Acid	0-14	insulin 1	Rattus norvegicus	107-112
18287347-0	2008	Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism.	Oleanolic Acid	0-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-108
18287347-6	2008	Oleanolic acid induced prostaglandin I2 (PGI2) release by human coronary SMC, an effect that was prevented by celecoxib (a specific inhibitor of Cox-2).	Oleanolic Acid	0-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
18287347-10	2008	Oleanolic acid induced an early phosphorylation of p38 MAPK and p42/44 MAPK but not c-Jun N-terminal kinase-1 (JNK-1).	Oleanolic Acid	0-14	cyclin dependent kinase 20	Homo sapiens	64-67
18287347-11	2008	SB203580 (p38MAPK inhibitor) and U0126 (MAPK kinase1/2 inhibitor) abrogated the upregulation of Cox-2 and PGI2 release induced by oleanolic acid.	Oleanolic Acid	130-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
18287347-14	2008	Therefore, oleanolic acid contributes to vascular homeostasis by inducing PGI2 release in a Cox-2-dependent manner.	Oleanolic Acid	11-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
18317437-5	2008	Peroxisome proliferator-activated receptor gamma ligands, including the thiazolidinedione class of antidiabetic drugs and novel triterpenoid compounds derived from oleanic acid, inhibit TGF-beta-stimulated profibrotic differentiation of lung fibroblasts in vitro and reduce lung scarring in animal models of fibrosis.	Oleanolic Acid	164-176	peroxisome proliferator activated receptor gamma	Homo sapiens	0-48
18317437-5	2008	Peroxisome proliferator-activated receptor gamma ligands, including the thiazolidinedione class of antidiabetic drugs and novel triterpenoid compounds derived from oleanic acid, inhibit TGF-beta-stimulated profibrotic differentiation of lung fibroblasts in vitro and reduce lung scarring in animal models of fibrosis.	Oleanolic Acid	164-176	transforming growth factor beta 1	Homo sapiens	186-194
17928930-0	2007	Oleanolic acid induces apoptosis in human leukemia cells through caspase activation and poly(ADP-ribose) polymerase cleavage.	Oleanolic Acid	0-14	poly(ADP-ribose) polymerase 1	Homo sapiens	88-115
17727365-0	2007	Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor-alpha.	Oleanolic Acid	40-54	peroxisome proliferator activated receptor alpha	Homo sapiens	145-193
17727365-5	2007	Finally, we observed that UA and ONA stimulated epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor (PPAR)-alpha using Western immunoblotting.	Oleanolic Acid	33-36	peroxisome proliferator activated receptor alpha	Homo sapiens	91-146
17727365-10	2007	Protein expression of PPAR-alpha, involucrin, loricrin and filaggrin increased twofold and threefold in HaCaT cells treated for 24 h with either ONA (10 micromol/L) or UA (10 micromol/L), respectively, reflecting that the UA and ONA can improve the recovery of skin barrier function and induce epidermal keratinocyte differentiation via PPAR-alpha.	Oleanolic Acid	145-148	peroxisome proliferator activated receptor alpha	Homo sapiens	22-32
17727365-10	2007	Protein expression of PPAR-alpha, involucrin, loricrin and filaggrin increased twofold and threefold in HaCaT cells treated for 24 h with either ONA (10 micromol/L) or UA (10 micromol/L), respectively, reflecting that the UA and ONA can improve the recovery of skin barrier function and induce epidermal keratinocyte differentiation via PPAR-alpha.	Oleanolic Acid	145-148	involucrin	Homo sapiens	34-44
17727365-10	2007	Protein expression of PPAR-alpha, involucrin, loricrin and filaggrin increased twofold and threefold in HaCaT cells treated for 24 h with either ONA (10 micromol/L) or UA (10 micromol/L), respectively, reflecting that the UA and ONA can improve the recovery of skin barrier function and induce epidermal keratinocyte differentiation via PPAR-alpha.	Oleanolic Acid	145-148	loricrin cornified envelope precursor protein	Homo sapiens	46-54
17727365-10	2007	Protein expression of PPAR-alpha, involucrin, loricrin and filaggrin increased twofold and threefold in HaCaT cells treated for 24 h with either ONA (10 micromol/L) or UA (10 micromol/L), respectively, reflecting that the UA and ONA can improve the recovery of skin barrier function and induce epidermal keratinocyte differentiation via PPAR-alpha.	Oleanolic Acid	145-148	peroxisome proliferator activated receptor alpha	Homo sapiens	337-347
17366743-0	2007	Oleanolic acid, a pentacyclic triterpenoid, induces rabbit platelet aggregation through a phospholipase C-calcium dependent signaling pathway.	Oleanolic Acid	0-14	LOC100009319	Oryctolagus cuniculus	90-105
17440087-5	2007	Using 4",6-diamidino-2-phenylindole and Annexin V, we showed that astrocytoma cell death induced by oleanolic acid or maslinic acid were mainly due to apoptotic events.	Oleanolic Acid	100-114	annexin A5	Homo sapiens	40-49
16889888-0	2007	Oleanolic acid inhibits the activity of the multidrug resistance protein ABCC1 (MRP1) but not of the ABCB1 (P-glycoprotein): possible use in cancer chemotherapy.	Oleanolic Acid	0-14	ATP binding cassette subfamily C member 1	Homo sapiens	44-78
16889888-0	2007	Oleanolic acid inhibits the activity of the multidrug resistance protein ABCC1 (MRP1) but not of the ABCB1 (P-glycoprotein): possible use in cancer chemotherapy.	Oleanolic Acid	0-14	ATP binding cassette subfamily C member 1	Homo sapiens	80-84
16889888-1	2007	The effects of oleanolic acid (OA) on ABCB1 and ABCC1 activities were studied in a cell line constitutively expressing both proteins.	Oleanolic Acid	31-33	ATP binding cassette subfamily B member 1	Homo sapiens	38-43
16889888-1	2007	The effects of oleanolic acid (OA) on ABCB1 and ABCC1 activities were studied in a cell line constitutively expressing both proteins.	Oleanolic Acid	31-33	ATP binding cassette subfamily C member 1	Homo sapiens	48-53
17366743-4	2007	Pretreating the platelets with U73122, a phospholipase C (PLC) inhibitor, blocked the oleanolic acid induced-aggregation, whereas acetylsalicylic acid (ASA), a cyclooxygenase (COX) inhibitor, had no effect.	Oleanolic Acid	86-100	LOC100009319	Oryctolagus cuniculus	41-56
17366743-4	2007	Pretreating the platelets with U73122, a phospholipase C (PLC) inhibitor, blocked the oleanolic acid induced-aggregation, whereas acetylsalicylic acid (ASA), a cyclooxygenase (COX) inhibitor, had no effect.	Oleanolic Acid	86-100	LOC100009319	Oryctolagus cuniculus	58-61
17366743-8	2007	Overall, these results suggest that oleanolic acid can induce platelet aggregation, which may be mediated by the stimulation of PLC-mediated cytosolic calcium mobilization.	Oleanolic Acid	36-50	LOC100009319	Oryctolagus cuniculus	128-131
16117609-5	2005	The momordin Ic and oleanolic acid pretreatments resulted in significantly lower serum transaminase, lactic dehydrogenase, and gamma-glutamyltransferase levels in the CCl4-treated rats.	Oleanolic Acid	20-34	C-C motif chemokine ligand 4	Rattus norvegicus	167-171
16988125-5	2006	Caspase-3 was activated in a dose-dependent manner after incubation for 24 h. The extract containing 200 micromol/L maslinic acid and 74 micromol/L oleanolic acid increased caspase-3-like activity to 6-fold that of control cells.	Oleanolic Acid	148-162	caspase 3	Homo sapiens	0-9
16988125-5	2006	Caspase-3 was activated in a dose-dependent manner after incubation for 24 h. The extract containing 200 micromol/L maslinic acid and 74 micromol/L oleanolic acid increased caspase-3-like activity to 6-fold that of control cells.	Oleanolic Acid	148-162	caspase 3	Homo sapiens	173-182
16364033-0	2006	Phytocomponents of triterpenoids, oleanolic acid and ursolic acid, regulated differently the processing of epidermal keratinocytes via PPAR-alpha pathway.	Oleanolic Acid	34-48	peroxisome proliferator activated receptor alpha	Homo sapiens	135-145
15880139-8	2005	PGF extract and its component oleanolic acid enhanced PPAR-alpha luciferase reporter gene activity in human embryonic kidney 293 cells, and this effect was completely suppressed by a selective PPAR-alpha antagonist MK-886, consistent with the presence of PPAR-alpha activator activity in the extract and this component.	Oleanolic Acid	30-44	peroxisome proliferator activated receptor alpha	Homo sapiens	54-64
15880139-8	2005	PGF extract and its component oleanolic acid enhanced PPAR-alpha luciferase reporter gene activity in human embryonic kidney 293 cells, and this effect was completely suppressed by a selective PPAR-alpha antagonist MK-886, consistent with the presence of PPAR-alpha activator activity in the extract and this component.	Oleanolic Acid	30-44	peroxisome proliferator activated receptor alpha	Homo sapiens	193-203
15880139-8	2005	PGF extract and its component oleanolic acid enhanced PPAR-alpha luciferase reporter gene activity in human embryonic kidney 293 cells, and this effect was completely suppressed by a selective PPAR-alpha antagonist MK-886, consistent with the presence of PPAR-alpha activator activity in the extract and this component.	Oleanolic Acid	30-44	peroxisome proliferator activated receptor alpha	Homo sapiens	193-203
16117609-7	2005	However, pretreatment with momordin Ic and oleanolic acid reduced the effect of CCl4 and helped maintain levels of the enzymes.	Oleanolic Acid	43-57	C-C motif chemokine ligand 4	Rattus norvegicus	80-84
16117609-8	2005	Pretreatment with momordin Ic and oleanolic acid resulted in significantly lower production of aminopyrine N-demethylase and aniline hydroxylase in the CCl4-treated rats.	Oleanolic Acid	34-48	C-C motif chemokine ligand 4	Rattus norvegicus	152-156
16117609-10	2005	Momordin Ic and oleanolic acid obtained from KF appear to contribute to alleviating the adverse effects of CCl4 treatment by enhancing the hepatic antioxidant defense system.	Oleanolic Acid	16-30	C-C motif chemokine ligand 4	Rattus norvegicus	107-111
16173536-1	2005	The protective effects of oleanolic acid (OA) on carbon tetrachloride (CCl4)-induced liver mitochondrial damage and the possible mechanisms were investigated.	Oleanolic Acid	26-40	chemokine (C-C motif) ligand 4	Mus musculus	71-75
15767573-1	2005	A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-gamma of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages.	Oleanolic Acid	53-67	interferon gamma	Mus musculus	152-161
15767573-1	2005	A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-gamma of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages.	Oleanolic Acid	53-67	nitric oxide synthase 2, inducible	Mus musculus	165-196
15767573-1	2005	A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-gamma of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages.	Oleanolic Acid	53-67	nitric oxide synthase 2, inducible	Mus musculus	198-202
15767573-1	2005	A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-gamma of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages.	Oleanolic Acid	53-67	prostaglandin-endoperoxide synthase 2	Mus musculus	211-227
15789744-3	2005	Of the isolated compounds, oleanolic acid (2), methyl ursolate (7) and corosolic aicd (8) inhibited DGAT, with IC50 values of 31.7, 26.4, and 44.3 microM, respectively.	Oleanolic Acid	27-41	diacylglycerol O-acyltransferase 1	Rattus norvegicus	100-104
16173536-1	2005	The protective effects of oleanolic acid (OA) on carbon tetrachloride (CCl4)-induced liver mitochondrial damage and the possible mechanisms were investigated.	Oleanolic Acid	42-44	chemokine (C-C motif) ligand 4	Mus musculus	71-75
15043991-0	2004	Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes.	Oleanolic Acid	44-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-29
15478202-2	2004	Selectivity for only one of the two receptors was exhibited by asiatic acid and its saponins (ETA) and oleanolic acid (AT1).	Oleanolic Acid	103-117	angiotensin II receptor type 1	Homo sapiens	119-122
15256709-3	2004	Among them, oleanolic acid (18) showed a significant inhibition effect on superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).	Oleanolic Acid	12-26	formyl peptide receptor 1	Homo sapiens	183-187
12186419-2	2002	In a cell-based ELISA, abrisapogenol E, soyasapogenols B and C, soyasapogenol B, kuzusapogenol B-methyl ester, and oleanolic acid significantly inhibited intercellular adhesion molecule (ICAM-1) expression.	Oleanolic Acid	115-129	intercellular adhesion molecule 1	Homo sapiens	187-193
12898427-0	2003	In vitro TGF-beta1 antagonistic activity of ursolic and oleanolic acids isolated from Clerodendranthus spicatus.	Oleanolic Acid	56-71	transforming growth factor beta 1	Homo sapiens	9-18
12444669-3	2002	The assay was validated with two natural triterpenoids, ursolic and oleanolic acid, known to inhibit COX-2, as well as with four synthetic COX inhibitors, NS-398, rofecoxib, indomethacin, and aspirin.	Oleanolic Acid	68-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-106
12898427-7	2003	Ursolic and oleanolic acids inhibited the binding of 125I-TGF-beta1 to its receptor with IC 50 values of 6.9 +/- 0.8 and 21.0 +/- 2.3 microM, respectively.	Oleanolic Acid	12-27	transforming growth factor beta 1	Homo sapiens	58-67
12031449-0	2002	Inhibition of alpha-glucosidase by oleanolic acid and its synthetic derivatives.	Oleanolic Acid	35-49	sucrase-isomaltase	Homo sapiens	14-31
10654412-6	1999	Also isolated as a DNA polymerase beta inhibitor was oleanolic acid (3).	Oleanolic Acid	53-67	DNA polymerase beta	Homo sapiens	19-38
18498484-5	2001	This phenolic substance showed more potent activity than that of reference compounds, oleanolic acid (76.5 mug mL(-1) for PPE, 219.2 mug mL(-1) for HNE) and ursolic acid (31.0 mug mL(-1) for PPE, 118.6 mug mL(-1) for HNE).	Oleanolic Acid	86-100	L1 cell adhesion molecule	Mus musculus	111-117
10355542-0	1999	Inhibition of cytochrome P450 2E1 expression by oleanolic acid: hepatoprotective effects against carbon tetrachloride-induced hepatic injury.	Oleanolic Acid	48-62	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	14-33
10355542-4	1999	The effects of oleanolic acid on the cytochrome P450 (P450) 2E1, the major isozyme involved in carbon tetrachloride bioactivation were investigated.	Oleanolic Acid	15-29	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	37-63
34896453-5	2022	Through screening by molecular docking, Oleanolic acid, Tryptanthrin, Chrysophanol and Rhein were found to have better spike protein and ACE2 inhibitory activity, which could block the invasion and recognition of SARS-CoV-2 at the same time, should be investigated as antiviral candidates.	Oleanolic Acid	40-54	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	119-124
8045916-3	1994	Moreover, expression of laminin B1, type IV collagen and retinoic acid receptor beta (RAR beta) increased in ursolic- and oleanolic-acid treated F9 cells.	Oleanolic Acid	122-136	retinoic acid receptor beta	Homo sapiens	57-84
8045916-3	1994	Moreover, expression of laminin B1, type IV collagen and retinoic acid receptor beta (RAR beta) increased in ursolic- and oleanolic-acid treated F9 cells.	Oleanolic Acid	122-136	retinoic acid receptor beta	Homo sapiens	86-94
34983881-0	2021	Oleanolic Acid Inhibits Neuronal Pyroptosis in Ischaemic Stroke by Inhibiting miR-186-5p Expression.	Oleanolic Acid	0-14	microRNA 186	Homo sapiens	78-85
34983881-2	2021	Previous studies have shown that oleanolic acid (OA) ameliorates oxidative injury and cerebral ischaemic damage, and miR-186-5p is verified to be elevated in serum from ischaemic stroke patients.	Oleanolic Acid	33-47	microRNA 186	Homo sapiens	117-124
10190183-6	1999	Ursolic acid exhibited IC50 values of 36.5 micrograms/mL and 28 micrograms/mL, and oleanolic acid exhibited IC50 values of 88.8 micrograms/mL and 70.6 micrograms/mL against K1 and T9-96, respectively.	Oleanolic Acid	83-97	keratin 1	Mus musculus	173-185
9848115-1	1998	Oleanolic acid (OA) has been shown to inhibit mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Oleanolic Acid	0-14	promotion susceptibility QTL 1	Mus musculus	114-117
9848115-1	1998	Oleanolic acid (OA) has been shown to inhibit mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Oleanolic Acid	16-18	promotion susceptibility QTL 1	Mus musculus	114-117
22778711-1	2012	Peroxisome proliferator activated receptor (PPAR)-gamma is a nuclear hormone receptor that is activated by multiple agonists including thiazolidinediones, prostaglandins, and synthetic oleanolic acids.	Oleanolic Acid	185-200	peroxisome proliferator activated receptor gamma	Homo sapiens	0-55
34753075-2	2022	Herein, naturally occurring bioactive oleanolic acid (OA) was used as a nanocarrier to overcome these shortcomings by fabricating Car-loaded OA nanoparticles (Car/OA NPs).	Oleanolic Acid	38-52	nuclear receptor subfamily 1 group I member 3	Homo sapiens	130-133
34753075-2	2022	Herein, naturally occurring bioactive oleanolic acid (OA) was used as a nanocarrier to overcome these shortcomings by fabricating Car-loaded OA nanoparticles (Car/OA NPs).	Oleanolic Acid	38-52	nuclear receptor subfamily 1 group I member 3	Homo sapiens	159-162
34896453-5	2022	Through screening by molecular docking, Oleanolic acid, Tryptanthrin, Chrysophanol and Rhein were found to have better spike protein and ACE2 inhibitory activity, which could block the invasion and recognition of SARS-CoV-2 at the same time, should be investigated as antiviral candidates.	Oleanolic Acid	40-54	angiotensin converting enzyme 2	Homo sapiens	137-141
34030574-3	2021	The most potent compounds were found to be oleanic acid, betulinic acid and celastrol with IC50 values of 3.89-5.07 muM, that acted as mixed (uncompetitive plus non-competitive) inhibitors of COMT, representing a new skeleton of COMT inhibitor.	Oleanolic Acid	43-55	catechol-O-methyltransferase	Homo sapiens	192-196
34388475-0	2021	Oleanolic acid regulates the Treg/Th17 imbalance in gastric cancer by targeting IL-6 with miR-98-5p.	Oleanolic Acid	0-14	interleukin 6	Homo sapiens	80-84
34388475-0	2021	Oleanolic acid regulates the Treg/Th17 imbalance in gastric cancer by targeting IL-6 with miR-98-5p.	Oleanolic Acid	0-14	microRNA 98	Homo sapiens	90-96
34030574-3	2021	The most potent compounds were found to be oleanic acid, betulinic acid and celastrol with IC50 values of 3.89-5.07 muM, that acted as mixed (uncompetitive plus non-competitive) inhibitors of COMT, representing a new skeleton of COMT inhibitor.	Oleanolic Acid	43-55	catechol-O-methyltransferase	Homo sapiens	229-233
34820872-0	2021	Oleanolic acid reduces oxidative stress and neuronal apoptosis after experimental subarachnoid hemorrhage by regulating Nrf2/HO-1 pathway.	Oleanolic Acid	0-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-124
34677731-4	2021	Therefore, we screened different components of Tulsi leaf and found that eugenol, but not other major components (e.g. ursolic acid, oleanolic acid and beta-caryophylline), inhibited the interaction between spike S1 and ACE2 in an AlphaScreen-based assay.	Oleanolic Acid	133-147	angiotensin converting enzyme 2	Homo sapiens	220-224
34820872-0	2021	Oleanolic acid reduces oxidative stress and neuronal apoptosis after experimental subarachnoid hemorrhage by regulating Nrf2/HO-1 pathway.	Oleanolic Acid	0-14	heme oxygenase 1	Rattus norvegicus	125-129
34583226-5	2021	We found that the phytochemical compounds, such as curcumin, naringenin, sulforaphane, diallyl disulfide, mangiferin, oleanolic acid, umbelliferone, daphnetin, quercetin, isorhamnetin-3-O-galactoside, hesperidin, diammonium glycyrrhizinate, corilagin, shikonin, farrerol, and chenpi, had the potential to improve the Nrf2-ARE signaling thereby combat hepatotoxicity.	Oleanolic Acid	118-132	NFE2 like bZIP transcription factor 2	Homo sapiens	317-321
34858181-11	2021	The results showed that the docking of paeoniflorin with glyceraldehyde 3-phosphate dehydrogenase (GAPDH), paeoniflorin and loganin with SRC, ginsenoside Rb1 with NR3C2, ursolic acid and oleanolic acid with IL-6, paeoniflorin docking VEGFA, and MMP9.	Oleanolic Acid	187-201	interleukin 6	Mus musculus	207-211
34703880-0	2021	Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis.	Oleanolic Acid	0-14	superoxide dismutase 1	Homo sapiens	84-88
34675190-0	2021	Correction: Oleanolic acid enhances neural stem cell migration, proliferation and differentiation in vitro by inhibiting GSK3beta activity.	Oleanolic Acid	12-26	glycogen synthase kinase 3 alpha	Homo sapiens	121-129
34681931-4	2021	The biological activity of oleanolic acid and its two semisynthetic derivatives, methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate (HIMOXOL) and 12alpha-bromo-3-hydroxyimonoolean-28 13-olide (Br-HIMOLID), was assessed in SK-BR-3 breast cancer cells (HER2-positive).	Oleanolic Acid	27-41	erb-b2 receptor tyrosine kinase 2	Homo sapiens	248-252
34603018-7	2021	As demonstrated by metadynamics simulation, oleanolic acid can destabilize the local minimum of the alphaM-I domain in the open conformation partially through disturbance of the interactions between alpha1 and alpha7 helices.	Oleanolic Acid	44-58	BCL2 related protein A1	Homo sapiens	199-216
34186120-8	2021	Among the identified compounds, rosmarinic acid, caffeic acid, oleanolic acid, and ursolic acid showed high catalytic activity of alpha amylase and alpha-glucosidase.	Oleanolic Acid	63-77	sucrase isomaltase (alpha-glucosidase)	Mus musculus	130-165
34481532-0	2021	Oleanolic acid inhibits the migration and invasion of hepatocellular carcinoma cells by promoting microRNA-122 expression.	Oleanolic Acid	0-14	microRNA 122	Homo sapiens	98-110
34481532-5	2021	In this study, we performed a cell-based screening method for discovering miR-122 activators and found that oleanolic acid (OA), a natural pentacyclic triterpene, specifically increased miR-122 expression in a concentration-dependent manner.	Oleanolic Acid	108-122	microRNA 122	Homo sapiens	74-81
34481532-5	2021	In this study, we performed a cell-based screening method for discovering miR-122 activators and found that oleanolic acid (OA), a natural pentacyclic triterpene, specifically increased miR-122 expression in a concentration-dependent manner.	Oleanolic Acid	108-122	microRNA 122	Homo sapiens	186-193
34536821-0	2021	Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-kappaB signaling pathway.	Oleanolic Acid	54-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
34536821-0	2021	Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-kappaB signaling pathway.	Oleanolic Acid	54-68	nuclear factor kappa B subunit 1	Homo sapiens	99-108
34777686-6	2021	By using surface plasmon resonance assay, licochalcone A and oleanolic acid were found to have good TLR-4-binding affinity.	Oleanolic Acid	61-75	toll-like receptor 4	Rattus norvegicus	100-105
34708631-6	2021	CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway.	Oleanolic Acid	64-78	mitogen activated protein kinase 14	Rattus norvegicus	173-176
34708631-6	2021	CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway.	Oleanolic Acid	64-78	mitogen-activated protein kinase 8	Rattus norvegicus	181-184
34708631-6	2021	CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway.	Oleanolic Acid	64-78	mitogen activated protein kinase 14	Rattus norvegicus	188-191
34708631-6	2021	CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway.	Oleanolic Acid	64-78	mitogen-activated protein kinase 8	Rattus norvegicus	230-233
34450377-4	2021	In a recent study, our laboratory established that the oleanolic acid (OA) derivative, K73-03, had a strong inhibitory effect on a SPINK1 overexpressed PCa cells.	Oleanolic Acid	55-69	serine peptidase inhibitor Kazal type 1	Homo sapiens	131-137
34153323-5	2021	RESULTS: Pretreatment of oleanolic acid alleviated MCAO-induced ischemia-reperfusion injury as indicated by the significant decreases in cerebral infarction area and neurological symptom score at 24 h post injury, Evans blue leakage, expression of matrix metalloproteinase 9 (MMP9) and occludin, dihydroethidium fluorescence, and block malonaldehyde generation.	Oleanolic Acid	25-39	matrix metallopeptidase 9	Mus musculus	248-274
34153323-5	2021	RESULTS: Pretreatment of oleanolic acid alleviated MCAO-induced ischemia-reperfusion injury as indicated by the significant decreases in cerebral infarction area and neurological symptom score at 24 h post injury, Evans blue leakage, expression of matrix metalloproteinase 9 (MMP9) and occludin, dihydroethidium fluorescence, and block malonaldehyde generation.	Oleanolic Acid	25-39	matrix metallopeptidase 9	Mus musculus	276-280
34153323-5	2021	RESULTS: Pretreatment of oleanolic acid alleviated MCAO-induced ischemia-reperfusion injury as indicated by the significant decreases in cerebral infarction area and neurological symptom score at 24 h post injury, Evans blue leakage, expression of matrix metalloproteinase 9 (MMP9) and occludin, dihydroethidium fluorescence, and block malonaldehyde generation.	Oleanolic Acid	25-39	occludin	Mus musculus	286-294
34171250-0	2021	The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl4-induced liver injury in vivo.	Oleanolic Acid	73-87	C-C motif chemokine ligand 4	Homo sapiens	133-137
34171250-2	2021	Herein, the novel oral nanocomplexes composed of deoxycholic acid-grafted chitosan and oleanolic acid were constructed to reverse the CCl4-induced acute liver damage in mice.	Oleanolic Acid	87-101	chemokine (C-C motif) ligand 4	Mus musculus	134-138
34326874-0	2021	Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.	Oleanolic Acid	0-14	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	55-59
34354687-0	2021	Viral UL8 Is Involved in the Antiviral Activity of Oleanolic Acid Against HSV-1 Infection.	Oleanolic Acid	51-65	helicase-primase subunit	Human alphaherpesvirus 1	6-9
34354687-5	2021	Mechanism studies showed that Oleanolic acid exerted its anti-HSV-1 activity in the immediate early stage of infection, which involved the dysregulation of viral UL8, a component of viral helicase-primase complex critical for viral replication.	Oleanolic Acid	30-44	helicase-primase subunit	Human alphaherpesvirus 1	162-165
34358114-0	2021	Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-kappaB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential.	Oleanolic Acid	37-51	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
34358114-0	2021	Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-kappaB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential.	Oleanolic Acid	37-51	nuclear factor kappa B subunit 1	Homo sapiens	82-91
34326874-0	2021	Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.	Oleanolic Acid	0-14	mechanistic target of rapamycin kinase	Homo sapiens	60-64
34093192-8	2021	The in vitro study indicated potent PTP1B inhibitory potential of M. conica with an IC50 value of 26.5 mug/ml as compared to the positive control, oleanolic acid (IC50 36.2 mug/ml).	Oleanolic Acid	147-161	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	36-41
34108504-3	2021	However, nine dietary scaffolds, such as silibinin, flavopiridol, oleandrin, ursolic acid, alpha-boswellic acid, beta-boswellic acid, triterpenoid, guggulsterone, and oleanolic acid potentially bound to the cavity of PI3K-alpha, PKC-eta, H-Ras, and Ras with the highest binding energy.	Oleanolic Acid	167-181	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	217-227
34108504-3	2021	However, nine dietary scaffolds, such as silibinin, flavopiridol, oleandrin, ursolic acid, alpha-boswellic acid, beta-boswellic acid, triterpenoid, guggulsterone, and oleanolic acid potentially bound to the cavity of PI3K-alpha, PKC-eta, H-Ras, and Ras with the highest binding energy.	Oleanolic Acid	167-181	HRas proto-oncogene, GTPase	Homo sapiens	238-243
35219117-4	2022	Specifically, EPR and two compounds, namely, hederagenin (HG) and oleanolic acid (OA), significantly downregulate the Aurora B pathway.	Oleanolic Acid	66-80	aurora kinase B	Homo sapiens	118-126
35605478-0	2022	Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis.	Oleanolic Acid	0-14	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	78-81
35605478-0	2022	Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis.	Oleanolic Acid	0-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	86-90
34348637-6	2021	Additionally, triterpene acid mixture (ursolic acid, oleanolic acid, and betulinic acid), also isolated from rosehip, has been reported to reduce the production of interleukin-6 and Tumor necrosis factor-alpha.	Oleanolic Acid	53-67	interleukin 6	Homo sapiens	164-177
34348637-6	2021	Additionally, triterpene acid mixture (ursolic acid, oleanolic acid, and betulinic acid), also isolated from rosehip, has been reported to reduce the production of interleukin-6 and Tumor necrosis factor-alpha.	Oleanolic Acid	53-67	tumor necrosis factor	Homo sapiens	182-209
35482141-0	2022	Functional network analysis of p85 and PI3K as potential gene targets and mechanism of oleanolic acid in overcoming breast cancer resistance to tamoxifen.	Oleanolic Acid	87-101	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	31-34
35369968-0	2022	Design and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs.	Oleanolic Acid	28-42	vascular endothelial growth factor A	Homo sapiens	89-93
35369968-0	2022	Design and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs.	Oleanolic Acid	28-42	kinase insert domain receptor	Homo sapiens	135-141
35369968-0	2022	Design and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs.	Oleanolic Acid	28-42	vascular endothelial growth factor A	Homo sapiens	58-62
35369968-2	2022	Recent studies have revealed that oleanolic acid (OA), a natural pentacyclic triterpenoid, inhibited the VEGF/VEGFR2 signaling pathway and angiogenesis in HUVECs, which may represent an attractive VEGF inhibitor.	Oleanolic Acid	34-48	vascular endothelial growth factor A	Homo sapiens	105-109
35369968-2	2022	Recent studies have revealed that oleanolic acid (OA), a natural pentacyclic triterpenoid, inhibited the VEGF/VEGFR2 signaling pathway and angiogenesis in HUVECs, which may represent an attractive VEGF inhibitor.	Oleanolic Acid	34-48	kinase insert domain receptor	Homo sapiens	110-116
35484734-7	2022	We found combining nano-sized oleanolic acid and lipid-lowering ketones can slow down the weight gain process in rats, reduce fasting blood glucose levels, increase the insulin sensitivity index, reduce the serum MDA, NO, and triglyceride content, and increase SOD, CAT activity.	Oleanolic Acid	30-44	catalase	Rattus norvegicus	266-269
35041911-0	2022	Oleanolic Acid-conjugated human serum albumin nanoparticles encapsulating doxorubicin as synergistic combination chemotherapy in oropharyngeal carcinoma and melanoma.	Oleanolic Acid	0-14	albumin	Homo sapiens	32-45
35221722-0	2022	Downregulated lncRNA SNHG18 Suppresses the Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma and Meditates the Antitumor Effect of Oleanolic Acid.	Oleanolic Acid	150-164	small nucleolar RNA host gene 18	Homo sapiens	21-27
35077758-0	2022	Oleanolic acid-loaded nanoparticles attenuate activation of hepatic stellate cells via suppressing TGF-beta1 and oxidative stress in PM2.5-exposed hepatocytes.	Oleanolic Acid	0-14	transforming growth factor beta 1	Homo sapiens	99-108
35128688-0	2022	Farnesoid X receptor contributes to oleanolic acid-induced cholestatic liver injury in mice.	Oleanolic Acid	36-50	nuclear receptor subfamily 1, group H, member 4	Mus musculus	0-20
34035231-8	2021	Consistently, AKR1B10 overexpression induced cancer cell aggressiveness, whereas suppression of AKR1B10 by siRNA or its small molecular inhibitor, oleanolic acid, reversed the CBX7 deficiency-induced cellular effects.	Oleanolic Acid	147-161	aldo-keto reductase family 1 member B10	Homo sapiens	96-103
34873072-0	2022	Oleanolic Acid Provides Neuroprotection against Ischemic Stroke through the Inhibition of Microglial Activation and NLRP3 Inflammasome Activation.	Oleanolic Acid	0-14	NLR family, pyrin domain containing 3	Mus musculus	116-121
34035231-8	2021	Consistently, AKR1B10 overexpression induced cancer cell aggressiveness, whereas suppression of AKR1B10 by siRNA or its small molecular inhibitor, oleanolic acid, reversed the CBX7 deficiency-induced cellular effects.	Oleanolic Acid	147-161	chromobox homolog 7a	Ictalurus punctatus	176-180
33747179-0	2021	Oleanolic acid inhibits osteosarcoma cell proliferation and invasion by suppressing the SOX9/Wnt1 signaling pathway.	Oleanolic Acid	0-14	SRY-box transcription factor 9	Homo sapiens	88-92
33747179-0	2021	Oleanolic acid inhibits osteosarcoma cell proliferation and invasion by suppressing the SOX9/Wnt1 signaling pathway.	Oleanolic Acid	0-14	Wnt family member 1	Homo sapiens	93-97
33747179-2	2021	Inhibition of SOX9/Wnt1-mediated signaling might suppress osteosarcoma metastasis, and oleanolic acid (OA) might decrease the activity of the SOX9/Wnt1 signaling pathway.	Oleanolic Acid	87-101	SRY-box transcription factor 9	Homo sapiens	142-146
33747179-2	2021	Inhibition of SOX9/Wnt1-mediated signaling might suppress osteosarcoma metastasis, and oleanolic acid (OA) might decrease the activity of the SOX9/Wnt1 signaling pathway.	Oleanolic Acid	87-101	Wnt family member 1	Homo sapiens	147-151
33666565-0	2021	Oleanolic acid derivative HA-20 inhibits adipogenesis in a manner involving PPARgamma-FABP4/aP2 pathway.	Oleanolic Acid	0-14	peroxisome proliferator activated receptor gamma	Mus musculus	76-85
33674782-5	2021	We confirmed known metabolite-target pairs such as nicotinic acid-GPR109a or linoleoyl ethanolamide-GPR119 and inferred interactions of interest including oleanolic acid-GABRG2 and alpha-CEHC-THRB.	Oleanolic Acid	155-169	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	170-176
33548628-0	2021	Oleanolic acid inhibits cervical cancer Hela cell proliferation through modulation of the ACSL4 ferroptosis signaling pathway.	Oleanolic Acid	0-14	acyl-CoA synthetase long chain family member 4	Homo sapiens	90-95
33841013-0	2021	20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis.	Oleanolic Acid	26-40	presenilin 1	Mus musculus	78-81
33666565-0	2021	Oleanolic acid derivative HA-20 inhibits adipogenesis in a manner involving PPARgamma-FABP4/aP2 pathway.	Oleanolic Acid	0-14	fatty acid binding protein 4, adipocyte	Mus musculus	86-91
33666565-0	2021	Oleanolic acid derivative HA-20 inhibits adipogenesis in a manner involving PPARgamma-FABP4/aP2 pathway.	Oleanolic Acid	0-14	fatty acid binding protein 4, adipocyte	Mus musculus	92-95
32894642-0	2021	Inhibition of NF-kappaB is required for oleanolic acid to downregulate PD-L1 by promoting DNA demethylation in gastric cancer cells.	Oleanolic Acid	40-54	nuclear factor kappa B subunit 1	Homo sapiens	14-23
33465424-0	2021	Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A.	Oleanolic Acid	52-66	TNF receptor associated protein 1	Homo sapiens	16-21
33345851-0	2021	Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation.	Oleanolic Acid	0-14	sirtuin 1	Rattus norvegicus	86-91
33345851-0	2021	Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation.	Oleanolic Acid	0-14	high mobility group box 1	Rattus norvegicus	101-106
33345851-7	2021	Then we found that oleanolic acid could inhibit the transfer of HMGB1 from nucleus to cytoplasm and reduce the level of serum HMGB1.	Oleanolic Acid	19-33	high mobility group box 1	Rattus norvegicus	64-69
33345851-7	2021	Then we found that oleanolic acid could inhibit the transfer of HMGB1 from nucleus to cytoplasm and reduce the level of serum HMGB1.	Oleanolic Acid	19-33	high mobility group box 1	Rattus norvegicus	126-131
33345851-8	2021	Furthermore, we found that oleanolic acid decreased the acetylation level of HMGB1 by increasing SIRT1 expression rather than by inhibiting JAK/STAT3 pathway.	Oleanolic Acid	27-41	high mobility group box 1	Rattus norvegicus	77-82
33345851-8	2021	Furthermore, we found that oleanolic acid decreased the acetylation level of HMGB1 by increasing SIRT1 expression rather than by inhibiting JAK/STAT3 pathway.	Oleanolic Acid	27-41	sirtuin 1	Rattus norvegicus	97-102
33345851-8	2021	Furthermore, we found that oleanolic acid decreased the acetylation level of HMGB1 by increasing SIRT1 expression rather than by inhibiting JAK/STAT3 pathway.	Oleanolic Acid	27-41	signal transducer and activator of transcription 3	Rattus norvegicus	144-149
33345851-9	2021	SIRT1 inhibitor sirtinol eliminated all beneficial effects of oleanolic acid on subarachnoid hemorrhage, which indicated that oleanolic acid inhibited the acetylation of HMGB1 by up regulating SIRT1.	Oleanolic Acid	62-76	sirtuin 1	Rattus norvegicus	0-5
33345851-9	2021	SIRT1 inhibitor sirtinol eliminated all beneficial effects of oleanolic acid on subarachnoid hemorrhage, which indicated that oleanolic acid inhibited the acetylation of HMGB1 by up regulating SIRT1.	Oleanolic Acid	62-76	high mobility group box 1	Rattus norvegicus	170-175
33345851-9	2021	SIRT1 inhibitor sirtinol eliminated all beneficial effects of oleanolic acid on subarachnoid hemorrhage, which indicated that oleanolic acid inhibited the acetylation of HMGB1 by up regulating SIRT1.	Oleanolic Acid	126-140	sirtuin 1	Rattus norvegicus	0-5
33345851-9	2021	SIRT1 inhibitor sirtinol eliminated all beneficial effects of oleanolic acid on subarachnoid hemorrhage, which indicated that oleanolic acid inhibited the acetylation of HMGB1 by up regulating SIRT1.	Oleanolic Acid	126-140	high mobility group box 1	Rattus norvegicus	170-175
33345851-9	2021	SIRT1 inhibitor sirtinol eliminated all beneficial effects of oleanolic acid on subarachnoid hemorrhage, which indicated that oleanolic acid inhibited the acetylation of HMGB1 by up regulating SIRT1.	Oleanolic Acid	126-140	sirtuin 1	Rattus norvegicus	193-198
33345851-10	2021	In addition, oleanolic acid treatment also reduced the levels of TLR4 and apoptosis related factors and reduced neuronal apoptosis after subarachnoid hemorrhage.	Oleanolic Acid	13-27	toll-like receptor 4	Rattus norvegicus	65-69
33345851-11	2021	In summary, our findings suggest that oleanolic acid may activate SIRT1 by acting as an activator of SIRT1, thereby reducing the acetylation of HMGB1, thus playing an anti-inflammatory role to alleviate early brain injury after subarachnoid hemorrhage.	Oleanolic Acid	38-52	sirtuin 1	Rattus norvegicus	66-71
33345851-11	2021	In summary, our findings suggest that oleanolic acid may activate SIRT1 by acting as an activator of SIRT1, thereby reducing the acetylation of HMGB1, thus playing an anti-inflammatory role to alleviate early brain injury after subarachnoid hemorrhage.	Oleanolic Acid	38-52	sirtuin 1	Rattus norvegicus	101-106
33345851-11	2021	In summary, our findings suggest that oleanolic acid may activate SIRT1 by acting as an activator of SIRT1, thereby reducing the acetylation of HMGB1, thus playing an anti-inflammatory role to alleviate early brain injury after subarachnoid hemorrhage.	Oleanolic Acid	38-52	high mobility group box 1	Rattus norvegicus	144-149
33567767-0	2021	Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Selective Vascular Endothelial Growth Factor Promoter i-Motif Ligands.	Oleanolic Acid	39-53	vascular endothelial growth factor A	Homo sapiens	79-113
33567767-4	2021	Herein, we report the discovery of the natural oleanolic acid scaffold as a novel chemotype for the development of selective ligands of VEGF i-motif.	Oleanolic Acid	47-61	vascular endothelial growth factor A	Homo sapiens	136-140
33567767-5	2021	A series of oleanolic acid derivatives as VEGF promoter i-motif ligands were synthesized.	Oleanolic Acid	12-26	vascular endothelial growth factor A	Homo sapiens	42-46
33567767-8	2021	This work provides evidence of VEGF promoter i-motif as an anticancer target and will facilitate future efforts for the discovery of oleanolic acid-based selective ligands of VEGF promoter i-motif.	Oleanolic Acid	133-147	vascular endothelial growth factor A	Homo sapiens	31-35
33567767-8	2021	This work provides evidence of VEGF promoter i-motif as an anticancer target and will facilitate future efforts for the discovery of oleanolic acid-based selective ligands of VEGF promoter i-motif.	Oleanolic Acid	133-147	vascular endothelial growth factor A	Homo sapiens	175-179
33562835-4	2021	Polyphyllin D was found to selectively inhibit SHP2 over SHP1, whereas two other identified compounds (echinocystic acid and oleanolic acid) demonstrated dual SHP1 and SHP2 inhibition.	Oleanolic Acid	125-139	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	159-163
33562835-4	2021	Polyphyllin D was found to selectively inhibit SHP2 over SHP1, whereas two other identified compounds (echinocystic acid and oleanolic acid) demonstrated dual SHP1 and SHP2 inhibition.	Oleanolic Acid	125-139	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	168-172
33574657-5	2021	Results: The results of in vitro studies revealed that derivatives 3d, 3e, 3L, and 3o are comparable to that of the oleanolic acid on the inhibition of TNF-alpha and IL-6 release.	Oleanolic Acid	116-130	tumor necrosis factor	Mus musculus	152-161
33574657-5	2021	Results: The results of in vitro studies revealed that derivatives 3d, 3e, 3L, and 3o are comparable to that of the oleanolic acid on the inhibition of TNF-alpha and IL-6 release.	Oleanolic Acid	116-130	interleukin 6	Mus musculus	166-170
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	58-72	sucrase-isomaltase	Homo sapiens	84-101
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	58-72	sucrase-isomaltase	Homo sapiens	161-178
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	74-76	sucrase-isomaltase	Homo sapiens	84-101
33418317-1	2021	Research efforts have been directed to the development of oleanolic acid (OA) based alpha-glucosidase inhibitors and various OA derivatives showed improved anti-alpha-glucosidase activity.	Oleanolic Acid	74-76	sucrase-isomaltase	Homo sapiens	161-178
33418317-7	2021	Findings from this study support that OA indole derivatives are promising alpha-glucosidase inhibitors as a potential management of diabetes mellitus.	Oleanolic Acid	38-40	sucrase-isomaltase	Homo sapiens	74-91
31888388-0	2021	Design and synthesis of VEGFR-2 inhibitors based on oleanolic acid moiety.	Oleanolic Acid	52-66	kinase insert domain receptor	Homo sapiens	24-31
31888388-1	2021	In this study, twenty-four oleanolic acid (OA) derivatives were rationally designed based on molecule docking studies and their VEGFR-2 inhibitory activities were tested by Homogeneous time-resolved fluorescence (HTRF) method in vitro.	Oleanolic Acid	27-41	kinase insert domain receptor	Homo sapiens	128-135
31888388-1	2021	In this study, twenty-four oleanolic acid (OA) derivatives were rationally designed based on molecule docking studies and their VEGFR-2 inhibitory activities were tested by Homogeneous time-resolved fluorescence (HTRF) method in vitro.	Oleanolic Acid	43-45	kinase insert domain receptor	Homo sapiens	128-135
31888388-4	2021	The results indicated that insertion of phenylurea group with a linker at position C-28 of OA can increase the activity against VEGFR-2 significantly.	Oleanolic Acid	91-93	kinase insert domain receptor	Homo sapiens	128-135
33573541-1	2021	Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by activating of the pituitary-adrenal cortical system, inhibiting the synthesis or release of PGs, inhibiting endotoxin-mediated release of HMGB1 by endothelial cells or regulating MAPK, PI3K/Akt/NF-kappaB/ICAM-1/JAK/STAT signaling pathways, etc.	Oleanolic Acid	0-14	high mobility group box 1	Homo sapiens	230-235
33573541-1	2021	Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by activating of the pituitary-adrenal cortical system, inhibiting the synthesis or release of PGs, inhibiting endotoxin-mediated release of HMGB1 by endothelial cells or regulating MAPK, PI3K/Akt/NF-kappaB/ICAM-1/JAK/STAT signaling pathways, etc.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	282-285
33573541-1	2021	Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by activating of the pituitary-adrenal cortical system, inhibiting the synthesis or release of PGs, inhibiting endotoxin-mediated release of HMGB1 by endothelial cells or regulating MAPK, PI3K/Akt/NF-kappaB/ICAM-1/JAK/STAT signaling pathways, etc.	Oleanolic Acid	0-14	nuclear factor kappa B subunit 1	Homo sapiens	286-295
33573541-1	2021	Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by activating of the pituitary-adrenal cortical system, inhibiting the synthesis or release of PGs, inhibiting endotoxin-mediated release of HMGB1 by endothelial cells or regulating MAPK, PI3K/Akt/NF-kappaB/ICAM-1/JAK/STAT signaling pathways, etc.	Oleanolic Acid	0-14	intercellular adhesion molecule 1	Homo sapiens	296-302
33459176-9	2021	oleanolic acid, ursolic acid, 3beta-acetoxyolean-12-en-27-oic acid and isovitexin followed by the binding free energy calculations using MM-GBSA and these molecules have stable interactions with PLpro protein binding site.	Oleanolic Acid	0-14	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	195-200
32894642-0	2021	Inhibition of NF-kappaB is required for oleanolic acid to downregulate PD-L1 by promoting DNA demethylation in gastric cancer cells.	Oleanolic Acid	40-54	CD274 molecule	Homo sapiens	71-76
32894642-4	2021	We investigated how the natural compound oleanolic acid (OA) affected PD-L1 expression in gastric cancer cells.	Oleanolic Acid	41-55	CD274 molecule	Sus scrofa	70-75
31742469-2	2020	In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported.	Oleanolic Acid	34-48	endogenous retrovirus group K member 16	Homo sapiens	65-69
33291121-0	2021	Oleanolic Acid Improves the Symptom of Renal Ischemia Reperfusion Injury via the PI3K/AKT Pathway.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
33130471-0	2021	Oleanolic acid protects against mast cell-mediated allergic responses by suppressing Akt/NF-kappaB and STAT1 activation.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	85-88
33130471-0	2021	Oleanolic acid protects against mast cell-mediated allergic responses by suppressing Akt/NF-kappaB and STAT1 activation.	Oleanolic Acid	0-14	nuclear factor kappa B subunit 1	Homo sapiens	89-98
33130471-0	2021	Oleanolic acid protects against mast cell-mediated allergic responses by suppressing Akt/NF-kappaB and STAT1 activation.	Oleanolic Acid	0-14	signal transducer and activator of transcription 1	Homo sapiens	103-108
33307789-1	2021	Brahucins A (1) and B (2), the new oleanane-type triterpene lactones, have been isolated from the EtOAc-soluble fraction of Spiraea brahuica Boiss, along with betulinic acid (3), oleanolic acid (4), 3-O-(beta-D-glucopyranosyl) oleanolic acid (5), vanillic acid (6) and caffeic acid (7), reported for the first time from this species.	Oleanolic Acid	179-193	immunoglobulin kappa variable 5-2	Homo sapiens	0-25
33125128-0	2020	Antihypertensive activity of oleanolic acid is mediated via downregulation of secretory phospholipase A2 and fatty acid synthase in spontaneously hypertensive rats.	Oleanolic Acid	29-43	phospholipase A2 group IIA	Rattus norvegicus	78-104
33125128-0	2020	Antihypertensive activity of oleanolic acid is mediated via downregulation of secretory phospholipase A2 and fatty acid synthase in spontaneously hypertensive rats.	Oleanolic Acid	29-43	fatty acid synthase	Rattus norvegicus	109-128
31742469-2	2020	In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported.	Oleanolic Acid	50-52	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	75-80
31742469-2	2020	In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported.	Oleanolic Acid	34-48	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	75-80
31742469-2	2020	In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported.	Oleanolic Acid	50-52	endogenous retrovirus group K member 16	Homo sapiens	65-69
33062145-0	2020	Oleanolic Acid Decreases IL-1beta-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF-kappaB Axis in Osteoarthritis.	Oleanolic Acid	0-14	interleukin 1 alpha	Homo sapiens	25-33
32818653-0	2020	miR-421 up-regulation by the oleanolic acid derivative K73-03 regulates epigenetically SPINK1 transcription in pancreatic cancer cells leading to metabolic changes and enhanced apoptosis.	Oleanolic Acid	29-43	microRNA 421	Homo sapiens	0-7
32818653-0	2020	miR-421 up-regulation by the oleanolic acid derivative K73-03 regulates epigenetically SPINK1 transcription in pancreatic cancer cells leading to metabolic changes and enhanced apoptosis.	Oleanolic Acid	29-43	keratin 73	Homo sapiens	55-58
32818653-0	2020	miR-421 up-regulation by the oleanolic acid derivative K73-03 regulates epigenetically SPINK1 transcription in pancreatic cancer cells leading to metabolic changes and enhanced apoptosis.	Oleanolic Acid	29-43	serine peptidase inhibitor Kazal type 1	Homo sapiens	87-93
33241461-9	2020	The proposed method was successfully applied to screen potential GAA inhibitors from oleanolic acid derivatives.	Oleanolic Acid	85-99	alpha glucosidase	Homo sapiens	65-68
33062145-0	2020	Oleanolic Acid Decreases IL-1beta-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF-kappaB Axis in Osteoarthritis.	Oleanolic Acid	0-14	sirtuin 3	Homo sapiens	93-98
33062145-0	2020	Oleanolic Acid Decreases IL-1beta-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF-kappaB Axis in Osteoarthritis.	Oleanolic Acid	0-14	nuclear factor kappa B subunit 1	Homo sapiens	99-108
33062145-7	2020	The anti-inflammatory effect of SIRT3 underlying in oleanolic acid- (OLA-) prevented interleukin-1beta- (IL-1beta-) induced FLS dysfunction is then evaluated in vitro.	Oleanolic Acid	52-66	sirtuin 3	Homo sapiens	32-37
33062145-7	2020	The anti-inflammatory effect of SIRT3 underlying in oleanolic acid- (OLA-) prevented interleukin-1beta- (IL-1beta-) induced FLS dysfunction is then evaluated in vitro.	Oleanolic Acid	52-66	interleukin 1 beta	Homo sapiens	85-102
33062145-7	2020	The anti-inflammatory effect of SIRT3 underlying in oleanolic acid- (OLA-) prevented interleukin-1beta- (IL-1beta-) induced FLS dysfunction is then evaluated in vitro.	Oleanolic Acid	52-66	interleukin 1 alpha	Homo sapiens	105-113
32100892-0	2020	Oleanolic acid alleviates oxidative stress in Alzheimer"s disease by regulating stanniocalcin-1 and uncoupling protein-2 signaling.	Oleanolic Acid	0-14	stanniocalcin 1	Mus musculus	80-120
32542667-7	2020	The effect of a combination with two natural compounds, oleanolic acid (OA) and ursolic acid (UA), was evaluated on the expression of the IL-8 axis and epithelial cell growth.	Oleanolic Acid	56-70	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
32542667-7	2020	The effect of a combination with two natural compounds, oleanolic acid (OA) and ursolic acid (UA), was evaluated on the expression of the IL-8 axis and epithelial cell growth.	Oleanolic Acid	72-74	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
32629283-0	2020	Synthesis and antitumor activity of alpha,beta-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway.	Oleanolic Acid	87-101	AKT serine/threonine kinase 1	Homo sapiens	129-132
32629283-0	2020	Synthesis and antitumor activity of alpha,beta-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway.	Oleanolic Acid	87-101	mechanistic target of rapamycin kinase	Homo sapiens	133-137
31795780-7	2020	Furthermore, our results also showed that OA could significantly decrease serum anti-dsDNA antibody levels, IL-17A and IFN-gamma expression and alleviate renal pathological damage in OA-treated group mice than in the model group mice.Conclusion: These results demonstrated that OA can improve the clinical manifestation of LN, indicating potential application in SLE therapy.	Oleanolic Acid	42-44	interleukin 17A	Mus musculus	108-114
31795780-7	2020	Furthermore, our results also showed that OA could significantly decrease serum anti-dsDNA antibody levels, IL-17A and IFN-gamma expression and alleviate renal pathological damage in OA-treated group mice than in the model group mice.Conclusion: These results demonstrated that OA can improve the clinical manifestation of LN, indicating potential application in SLE therapy.	Oleanolic Acid	42-44	interferon gamma	Mus musculus	119-128
31795780-7	2020	Furthermore, our results also showed that OA could significantly decrease serum anti-dsDNA antibody levels, IL-17A and IFN-gamma expression and alleviate renal pathological damage in OA-treated group mice than in the model group mice.Conclusion: These results demonstrated that OA can improve the clinical manifestation of LN, indicating potential application in SLE therapy.	Oleanolic Acid	183-185	interferon gamma	Mus musculus	119-128
31795780-7	2020	Furthermore, our results also showed that OA could significantly decrease serum anti-dsDNA antibody levels, IL-17A and IFN-gamma expression and alleviate renal pathological damage in OA-treated group mice than in the model group mice.Conclusion: These results demonstrated that OA can improve the clinical manifestation of LN, indicating potential application in SLE therapy.	Oleanolic Acid	183-185	interferon gamma	Mus musculus	119-128
32699194-4	2020	TGR5-specific agonist oleanolic acid induced NG neuronal firing in a dose-dependent manner.	Oleanolic Acid	22-36	G protein-coupled bile acid receptor 1	Rattus norvegicus	0-4
32534078-0	2020	Oleanolic acid induces a dual agonist action on PPARgamma/alpha and GLUT4 translocation: A pentacyclic triterpene for dyslipidemia and type 2 diabetes.	Oleanolic Acid	0-14	peroxisome proliferator activated receptor gamma	Homo sapiens	48-63
32534078-0	2020	Oleanolic acid induces a dual agonist action on PPARgamma/alpha and GLUT4 translocation: A pentacyclic triterpene for dyslipidemia and type 2 diabetes.	Oleanolic Acid	0-14	solute carrier family 2 member 4	Homo sapiens	68-73
32133639-3	2020	Previously, we found out that oleanolic acid, which is similar chemical structure with maslinic acid, ameliorates cognitive impairment through the activation of tropomyosin receptor kinase (TrkB)-extracellular-signal-regulated kinase (ERK)-cAMP response element-binding protein (CREB) phosphorylation and increased levels of brain-derived neurotrophic factor (BDNF).	Oleanolic Acid	30-44	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	190-194
32133639-3	2020	Previously, we found out that oleanolic acid, which is similar chemical structure with maslinic acid, ameliorates cognitive impairment through the activation of tropomyosin receptor kinase (TrkB)-extracellular-signal-regulated kinase (ERK)-cAMP response element-binding protein (CREB) phosphorylation and increased levels of brain-derived neurotrophic factor (BDNF).	Oleanolic Acid	30-44	cAMP responsive element binding protein 1	Mus musculus	279-283
32133639-3	2020	Previously, we found out that oleanolic acid, which is similar chemical structure with maslinic acid, ameliorates cognitive impairment through the activation of tropomyosin receptor kinase (TrkB)-extracellular-signal-regulated kinase (ERK)-cAMP response element-binding protein (CREB) phosphorylation and increased levels of brain-derived neurotrophic factor (BDNF).	Oleanolic Acid	30-44	brain derived neurotrophic factor	Mus musculus	325-358
32133639-3	2020	Previously, we found out that oleanolic acid, which is similar chemical structure with maslinic acid, ameliorates cognitive impairment through the activation of tropomyosin receptor kinase (TrkB)-extracellular-signal-regulated kinase (ERK)-cAMP response element-binding protein (CREB) phosphorylation and increased levels of brain-derived neurotrophic factor (BDNF).	Oleanolic Acid	30-44	brain derived neurotrophic factor	Mus musculus	360-364
32559584-2	2020	PURPOSE: We evaluated the cytotoxic potential of a naturally occurring N-acetylglycoside of oleanolic acid, aridanin, on 18 cancer cell lines, including sensitive and drug-resistant phenotypes mediated by P-glycoprotein, BCRP, p53 knockout, deletion-mutated EGFR, or BRAF mutations.	Oleanolic Acid	92-106	ATP binding cassette subfamily B member 1	Homo sapiens	205-219
32559584-2	2020	PURPOSE: We evaluated the cytotoxic potential of a naturally occurring N-acetylglycoside of oleanolic acid, aridanin, on 18 cancer cell lines, including sensitive and drug-resistant phenotypes mediated by P-glycoprotein, BCRP, p53 knockout, deletion-mutated EGFR, or BRAF mutations.	Oleanolic Acid	92-106	BCR pseudogene 1	Homo sapiens	221-225
32559584-2	2020	PURPOSE: We evaluated the cytotoxic potential of a naturally occurring N-acetylglycoside of oleanolic acid, aridanin, on 18 cancer cell lines, including sensitive and drug-resistant phenotypes mediated by P-glycoprotein, BCRP, p53 knockout, deletion-mutated EGFR, or BRAF mutations.	Oleanolic Acid	92-106	tumor protein p53	Homo sapiens	227-230
32559584-2	2020	PURPOSE: We evaluated the cytotoxic potential of a naturally occurring N-acetylglycoside of oleanolic acid, aridanin, on 18 cancer cell lines, including sensitive and drug-resistant phenotypes mediated by P-glycoprotein, BCRP, p53 knockout, deletion-mutated EGFR, or BRAF mutations.	Oleanolic Acid	92-106	epidermal growth factor receptor	Homo sapiens	258-262
32559584-2	2020	PURPOSE: We evaluated the cytotoxic potential of a naturally occurring N-acetylglycoside of oleanolic acid, aridanin, on 18 cancer cell lines, including sensitive and drug-resistant phenotypes mediated by P-glycoprotein, BCRP, p53 knockout, deletion-mutated EGFR, or BRAF mutations.	Oleanolic Acid	92-106	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	267-271
31924596-0	2020	Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis via the blockage of p38 and JNK MAPKs.	Oleanolic Acid	0-14	mitogen-activated protein kinase 14	Mus musculus	116-119
32267554-4	2020	In addition, oleanolic acid was the dominant compound act on the Bel-7402 cells in the extract and it induced apoptosis by the caspase pathway and induced cell cycle arrest at the G0/G1 phase by inhibiting the cyclin D1/CDK4 pathway.	Oleanolic Acid	13-27	cyclin D1	Homo sapiens	210-219
32267554-4	2020	In addition, oleanolic acid was the dominant compound act on the Bel-7402 cells in the extract and it induced apoptosis by the caspase pathway and induced cell cycle arrest at the G0/G1 phase by inhibiting the cyclin D1/CDK4 pathway.	Oleanolic Acid	13-27	cyclin dependent kinase 4	Homo sapiens	220-224
30580622-7	2020	Specifically, ursolic acid and oleanolic acid showed better ACE inhibition than the other compounds.	Oleanolic Acid	31-45	angiotensin I converting enzyme	Rattus norvegicus	60-63
32191471-0	2020	Oleanolic Acid Ameliorates Benign Prostatic Hyperplasia by Regulating PCNA-Dependent Cell Cycle Progression In Vivo and In Vitro.	Oleanolic Acid	0-14	proliferating cell nuclear antigen	Rattus norvegicus	70-74
32328123-0	2020	Oleanolic Acid Attenuates Renal Fibrosis through TGF-beta/Smad Pathway in a Rat Model of Unilateral Ureteral Obstruction.	Oleanolic Acid	0-14	transforming growth factor alpha	Rattus norvegicus	49-57
32328123-7	2020	As a result, oleanolic acid significantly reduced the kidney index, the level of serum creatinine and blood urea nitrogen, and the urinary level of microalbumin, alpha1-microglobulin, and N-acetyl-beta-glucosaminidase.	Oleanolic Acid	13-27	O-GlcNAcase	Rattus norvegicus	188-217
32328123-10	2020	Oleanolic acid led to decreased protein expressions of TGF-beta, TGF-beta receptor I, and TGF-beta receptor II, as well as the phosphorylation of Smad2.	Oleanolic Acid	0-14	transforming growth factor alpha	Rattus norvegicus	55-63
32328123-10	2020	Oleanolic acid led to decreased protein expressions of TGF-beta, TGF-beta receptor I, and TGF-beta receptor II, as well as the phosphorylation of Smad2.	Oleanolic Acid	0-14	SMAD family member 2	Rattus norvegicus	146-151
32328123-11	2020	Our current study suggested that oleanolic acid could be a complementary and alternative therapy for renal fibrosis potentially by targeting the TGF-beta/Smad pathway.	Oleanolic Acid	33-47	transforming growth factor alpha	Rattus norvegicus	145-153
32448034-3	2021	In the current study, we report novel natural metabolites namely, ursolic acid, carvacrol and oleanolic acid as the potential inhibitors against main protease (Mpro) of COVID-19 by using integrated molecular modeling approaches.	Oleanolic Acid	94-108	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	160-164
32448034-8	2021	ursolic acid, carvacrol and oleanolic acid could serve as potential inhibitors in regulating the Mpro protein"s function and controlling viral replication.	Oleanolic Acid	28-42	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	97-101
32037581-0	2020	A Gold(I) Complex Containing an Oleanolic Acid Derivative as a Potential Anti-ovarian Cancer Agent via Inhibiting TrxR and Activating ROS-mediated ERS.	Oleanolic Acid	32-46	peroxiredoxin 5	Homo sapiens	114-118
32028542-0	2020	Oleanolic acid mitigates interleukin-1beta-induced chondrocyte dysfunction by regulating miR-148-3p-modulated FGF2 expression.	Oleanolic Acid	0-14	interleukin 1 beta	Homo sapiens	25-42
32028542-0	2020	Oleanolic acid mitigates interleukin-1beta-induced chondrocyte dysfunction by regulating miR-148-3p-modulated FGF2 expression.	Oleanolic Acid	0-14	fibroblast growth factor 2	Homo sapiens	110-114
32028542-2	2020	The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid (OLA)-prevented interleukin-1beta (IL-1beta)-induced chondrocyte dysfunction via the miR-148-3p/FGF2 signaling pathway.	Oleanolic Acid	81-95	interleukin 1 beta	Homo sapiens	112-129
32028542-2	2020	The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid (OLA)-prevented interleukin-1beta (IL-1beta)-induced chondrocyte dysfunction via the miR-148-3p/FGF2 signaling pathway.	Oleanolic Acid	81-95	interleukin 1 alpha	Homo sapiens	131-139
32028542-2	2020	The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid (OLA)-prevented interleukin-1beta (IL-1beta)-induced chondrocyte dysfunction via the miR-148-3p/FGF2 signaling pathway.	Oleanolic Acid	81-95	fibroblast growth factor 2	Homo sapiens	192-196
32028542-2	2020	The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid (OLA)-prevented interleukin-1beta (IL-1beta)-induced chondrocyte dysfunction via the miR-148-3p/FGF2 signaling pathway.	Oleanolic Acid	97-100	interleukin 1 beta	Homo sapiens	112-129
32028542-2	2020	The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid (OLA)-prevented interleukin-1beta (IL-1beta)-induced chondrocyte dysfunction via the miR-148-3p/FGF2 signaling pathway.	Oleanolic Acid	97-100	interleukin 1 alpha	Homo sapiens	131-139
32028542-2	2020	The present study is aimed to investigate the molecular mechanisms underlying in oleanolic acid (OLA)-prevented interleukin-1beta (IL-1beta)-induced chondrocyte dysfunction via the miR-148-3p/FGF2 signaling pathway.	Oleanolic Acid	97-100	fibroblast growth factor 2	Homo sapiens	192-196
32028542-7	2020	RESULTS: Treatment with OLA counteracted IL-1beta-evoked chondrocyte growth inhibition, apoptosis, caspase3 production, MDA and 8-OHdG release.	Oleanolic Acid	24-27	interleukin 1 alpha	Homo sapiens	41-49
32028542-7	2020	RESULTS: Treatment with OLA counteracted IL-1beta-evoked chondrocyte growth inhibition, apoptosis, caspase3 production, MDA and 8-OHdG release.	Oleanolic Acid	24-27	caspase 3	Homo sapiens	99-107
32028542-8	2020	Additionally, FGF2 protein expression levels elevated by IL-1beta were down-regulated by OLA and miR-148-3p mimics transfection.	Oleanolic Acid	89-92	fibroblast growth factor 2	Homo sapiens	14-18
32028542-8	2020	Additionally, FGF2 protein expression levels elevated by IL-1beta were down-regulated by OLA and miR-148-3p mimics transfection.	Oleanolic Acid	89-92	interleukin 1 alpha	Homo sapiens	57-65
32028542-9	2020	IL-1beta-induced down-regulation of miR-148-3p in chondrocytes was evaluated by OLA administration.	Oleanolic Acid	80-83	interleukin 1 alpha	Homo sapiens	0-8
32028542-12	2020	CONCLUSIONS: Our present findings expounded a protective effect of OLA on IL-1beta-induced chondrocyte dysfunction, and a novel signal cascade the miR-148-3p/FGF2 signaling pathway might be a potential therapeutic target of OLA to prevent the progression of osteoarthritis (OA).	Oleanolic Acid	67-70	interleukin 1 alpha	Homo sapiens	74-82
32028542-12	2020	CONCLUSIONS: Our present findings expounded a protective effect of OLA on IL-1beta-induced chondrocyte dysfunction, and a novel signal cascade the miR-148-3p/FGF2 signaling pathway might be a potential therapeutic target of OLA to prevent the progression of osteoarthritis (OA).	Oleanolic Acid	224-227	interleukin 1 alpha	Homo sapiens	74-82
32028542-12	2020	CONCLUSIONS: Our present findings expounded a protective effect of OLA on IL-1beta-induced chondrocyte dysfunction, and a novel signal cascade the miR-148-3p/FGF2 signaling pathway might be a potential therapeutic target of OLA to prevent the progression of osteoarthritis (OA).	Oleanolic Acid	224-227	fibroblast growth factor 2	Homo sapiens	158-162
32176505-10	2020	The aim of this study was to investigate the properties of oleanolic acid in the presence of human serum albumin in terms of thermodynamics, morphology, and viscoelasticity at the air/water interface.	Oleanolic Acid	59-73	albumin	Homo sapiens	99-112
31924596-0	2020	Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis via the blockage of p38 and JNK MAPKs.	Oleanolic Acid	0-14	mitogen-activated protein kinase 8	Mus musculus	124-127
31924596-10	2020	Furthermore, SCI mice exhibited higher activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB) signaling pathways, but these effects were clearly blocked in SCI mice with OA treatments, as evidenced by the down-regulated phosphorylation of p38, c-Jun-NH 2 terminal kinase (JNK), IkappaB kinase alpha (IKKalpha), inhibitor of nuclear factor kappaB-alpha (IkappaBalpha) and NF-kappaB.	Oleanolic Acid	209-211	mitogen-activated protein kinase 14	Mus musculus	278-281
31924596-10	2020	Furthermore, SCI mice exhibited higher activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB) signaling pathways, but these effects were clearly blocked in SCI mice with OA treatments, as evidenced by the down-regulated phosphorylation of p38, c-Jun-NH 2 terminal kinase (JNK), IkappaB kinase alpha (IKKalpha), inhibitor of nuclear factor kappaB-alpha (IkappaBalpha) and NF-kappaB.	Oleanolic Acid	209-211	mitogen-activated protein kinase 8	Mus musculus	283-309
31924596-10	2020	Furthermore, SCI mice exhibited higher activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB) signaling pathways, but these effects were clearly blocked in SCI mice with OA treatments, as evidenced by the down-regulated phosphorylation of p38, c-Jun-NH 2 terminal kinase (JNK), IkappaB kinase alpha (IKKalpha), inhibitor of nuclear factor kappaB-alpha (IkappaBalpha) and NF-kappaB.	Oleanolic Acid	209-211	mitogen-activated protein kinase 8	Mus musculus	311-314
31924596-10	2020	Furthermore, SCI mice exhibited higher activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB) signaling pathways, but these effects were clearly blocked in SCI mice with OA treatments, as evidenced by the down-regulated phosphorylation of p38, c-Jun-NH 2 terminal kinase (JNK), IkappaB kinase alpha (IKKalpha), inhibitor of nuclear factor kappaB-alpha (IkappaBalpha) and NF-kappaB.	Oleanolic Acid	209-211	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	392-404
31924596-11	2020	The protective effects of OA against SCI were confirmed in lipopolysaccharide (LPS)-stimulated mouse neurons mainly through the suppression of apoptosis and inflammatory response, which were tightly associated with the blockage of p38 and JNK activation.	Oleanolic Acid	26-28	mitogen-activated protein kinase 14	Mus musculus	231-234
31924596-11	2020	The protective effects of OA against SCI were confirmed in lipopolysaccharide (LPS)-stimulated mouse neurons mainly through the suppression of apoptosis and inflammatory response, which were tightly associated with the blockage of p38 and JNK activation.	Oleanolic Acid	26-28	mitogen-activated protein kinase 8	Mus musculus	239-242
31924596-12	2020	Together, our data demonstrated that OA treatments could dose-dependently ameliorate spinal cord damage through impeding p38- and JNK-regulated apoptosis and inflammation, and therefore OA might be served as an effective therapeutic agent for SCI treatment.	Oleanolic Acid	37-39	mitogen-activated protein kinase 14	Mus musculus	121-124
31924596-12	2020	Together, our data demonstrated that OA treatments could dose-dependently ameliorate spinal cord damage through impeding p38- and JNK-regulated apoptosis and inflammation, and therefore OA might be served as an effective therapeutic agent for SCI treatment.	Oleanolic Acid	37-39	mitogen-activated protein kinase 8	Mus musculus	130-133
31825448-0	2020	Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium-induced diarrhea in mice via the TLR4/NF-kappaB and MAPK pathway.	Oleanolic Acid	0-14	toll-like receptor 4	Mus musculus	128-132
31845520-9	2020	Oleanolic acid and ursolic acid from Ligustri Lucidi Fructus were chosen as ADA inhibitors with half maximal inhibitory concentration values of 21.82 +- 0.39 and 18.41 +- 0.14 mum, respectively.	Oleanolic Acid	0-14	adenosine deaminase	Homo sapiens	76-79
31825448-0	2020	Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium-induced diarrhea in mice via the TLR4/NF-kappaB and MAPK pathway.	Oleanolic Acid	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	133-142
31547522-5	2019	Ursolic acid activates AKT/mTOR pathways and oleanolic acid triggers a pathway independent on AKT.	Oleanolic Acid	45-59	AKT serine/threonine kinase 1	Homo sapiens	94-97
32194806-0	2020	Nanocrystallized Oleanolic Acid Better Inhibits Proliferation, Migration and Invasion in Intracranial Glioma via Caspase-3 Pathway.	Oleanolic Acid	17-31	caspase 3	Homo sapiens	113-122
31704064-0	2020	P-glycoprotein modulates oleanolic acid effects in hepatocytes cancer cells and zebrafish embryos.	Oleanolic Acid	25-39	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
31704064-11	2020	These results demonstrate that inhibiting P-gp enhances the chemotherapeutic activity of OA.	Oleanolic Acid	89-91	ATP binding cassette subfamily B member 1	Homo sapiens	42-46
31318102-0	2020	Oleanolic acid exerts inhibitory effects on the late stage of osteoclastogenesis and prevents bone loss in osteoprotegerin knockout mice.	Oleanolic Acid	0-14	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	107-122
31743023-6	2019	The isolated cyanidin-3-arabinoside (Cya-3-Ara) exhibited a better inhibitory activity with IC50 = 8.91 +- 0.63 muM, which was higher than positive control (oleanolic acid, IC50 = 13.9 +- 1.01 muM) and the mechanism of PTP1B inhibition was reversible mixed.	Oleanolic Acid	157-171	p21 (RAC1) activated kinase 3	Homo sapiens	43-46
31743023-10	2019	Cya-3-Ara could also be regarded as a synergistic inhibitor (CI <= 0.54) of oleanolic acid to obtain a better inhibitory effect on PTP1B.	Oleanolic Acid	79-93	p21 (RAC1) activated kinase 3	Homo sapiens	6-9
31743023-10	2019	Cya-3-Ara could also be regarded as a synergistic inhibitor (CI <= 0.54) of oleanolic acid to obtain a better inhibitory effect on PTP1B.	Oleanolic Acid	79-93	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	134-139
32082922-11	2019	However, the groups that were treated with oleanolic acid showed a significant decrease compared to the peroxynitrite groups (p<0.001 for tumor necrosis factor alpha and apoptosis results at 48 h).	Oleanolic Acid	43-57	tumor necrosis factor	Rattus norvegicus	141-168
31611795-0	2019	Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR.	Oleanolic Acid	0-14	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	39-45
31611795-0	2019	Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR.	Oleanolic Acid	0-14	nuclear receptor subfamily 1 group I member 2	Homo sapiens	86-89
31611795-0	2019	Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR.	Oleanolic Acid	0-14	nuclear receptor subfamily 1 group I member 3	Homo sapiens	102-105
31611795-2	2019	We previously demonstrated that UA can inhibit the activities of UGT1A3 and UGT1A4, and OA inhibits UGT1A3 activity in liver microsomes.	Oleanolic Acid	88-90	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	100-106
31611795-3	2019	However, whether OA and UA affect the expression of UGT1As in HepG2 cells and the underlying regulatory mechanism remain unclear.	Oleanolic Acid	17-19	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	52-56
31611795-4	2019	Purpose: The present study aimed to explore the effect of OA and UA on the expression of UGT1As in HepG2 cells and the regulatory mechanisms on UGT1A1 based on the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) signaling pathways.	Oleanolic Acid	58-60	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	89-93
31721574-0	2019	Correction to "Hybrid Molecule from O2-(2,4-Dinitrophenyl)diazeniumdiolate and Oleanolic Acid: A Glutathione S-Transferase pi-Activated Nitric Oxide Prodrug with Selective Anti-Human Hepatocellular Carcinoma Activity and Improved Stability".	Oleanolic Acid	79-93	glutathione S-transferase kappa 1	Homo sapiens	97-122
31421088-0	2019	An oleanolic acid derivative reduces denervation-induced muscle atrophy via activation of CNTF-mediated JAK2/STAT3 signaling pathway.	Oleanolic Acid	3-17	ciliary neurotrophic factor	Homo sapiens	90-94
31421088-0	2019	An oleanolic acid derivative reduces denervation-induced muscle atrophy via activation of CNTF-mediated JAK2/STAT3 signaling pathway.	Oleanolic Acid	3-17	Janus kinase 2	Homo sapiens	104-108
31421088-0	2019	An oleanolic acid derivative reduces denervation-induced muscle atrophy via activation of CNTF-mediated JAK2/STAT3 signaling pathway.	Oleanolic Acid	3-17	signal transducer and activator of transcription 3	Homo sapiens	109-114
31421088-6	2019	In the present study, an oleanolic acid derivative, HA-19, increased the proliferation of Schwann cells, and elevated CNTF production of the cells.	Oleanolic Acid	25-39	ciliary neurotrophic factor	Homo sapiens	118-122
31410746-0	2019	Oleanolic acid attenuated diabetic mesangial cell injury by activation of autophagy via miRNA-142-5p/PTEN signaling.	Oleanolic Acid	0-14	phosphatase and tensin homolog	Rattus norvegicus	101-105
31611795-6	2019	Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR.	Oleanolic Acid	25-27	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	80-86
31611795-6	2019	Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR.	Oleanolic Acid	25-27	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	88-94
31611795-6	2019	Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR.	Oleanolic Acid	25-27	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	96-102
31611795-6	2019	Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR.	Oleanolic Acid	25-27	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	108-114
31611795-6	2019	Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR.	Oleanolic Acid	25-27	nuclear receptor subfamily 1 group I member 2	Homo sapiens	149-152
31611795-8	2019	A dual-luciferase reporter assay showed that OA and UA could markedly promote PXR-mediated UGT1A1 luciferase activity, whereas OA and UA did not affect CAR-mediated UGT1A1 luciferase activity.	Oleanolic Acid	45-47	nuclear receptor subfamily 1 group I member 2	Homo sapiens	78-81
31611795-8	2019	A dual-luciferase reporter assay showed that OA and UA could markedly promote PXR-mediated UGT1A1 luciferase activity, whereas OA and UA did not affect CAR-mediated UGT1A1 luciferase activity.	Oleanolic Acid	45-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	91-97
31611795-10	2019	However, the expression of UGT1A1 in hCAR-silenced HepG2 cells was markedly elevated compared to the control group or with non-silenced HepG2 cells treated with OA (10, 20, and 40 muM) or UA (10, 20, and 40 muM).	Oleanolic Acid	161-163	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	27-33
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	Oleanolic Acid	13-15	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	62-68
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	Oleanolic Acid	13-15	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	70-76
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	Oleanolic Acid	13-15	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	78-84
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	Oleanolic Acid	13-15	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	90-96
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	Oleanolic Acid	13-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	136-142
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	Oleanolic Acid	13-15	nuclear receptor subfamily 1 group I member 2	Homo sapiens	158-161
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	Oleanolic Acid	13-15	nuclear receptor subfamily 1 group I member 3	Homo sapiens	178-181
31547522-7	2019	The PINK1/Parkin axis is a pathway usually associated with mitophagy, however, the mitophagy induced by ursolic or oleanolic acid is just dependent on PINK1.	Oleanolic Acid	115-129	PTEN induced kinase 1	Homo sapiens	4-9
31547522-7	2019	The PINK1/Parkin axis is a pathway usually associated with mitophagy, however, the mitophagy induced by ursolic or oleanolic acid is just dependent on PINK1.	Oleanolic Acid	115-129	PTEN induced kinase 1	Homo sapiens	151-156
31153932-0	2019	Oleanolic acid decreases SGK1 in the hippocampus in corticosterone-induced mice.	Oleanolic Acid	0-14	serum/glucocorticoid regulated kinase 1	Mus musculus	25-29
31271843-0	2019	Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells.	Oleanolic Acid	0-14	Yes1 associated transcriptional regulator	Homo sapiens	81-103
31176167-0	2019	Oleanolic acid inhibits RANKL-induced osteoclastogenesis via ER alpha/miR-503/RANK signaling pathway in RAW264.7 cells.	Oleanolic Acid	0-14	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	24-29
31176167-0	2019	Oleanolic acid inhibits RANKL-induced osteoclastogenesis via ER alpha/miR-503/RANK signaling pathway in RAW264.7 cells.	Oleanolic Acid	0-14	estrogen receptor 1 (alpha)	Mus musculus	61-69
31176167-0	2019	Oleanolic acid inhibits RANKL-induced osteoclastogenesis via ER alpha/miR-503/RANK signaling pathway in RAW264.7 cells.	Oleanolic Acid	0-14	microRNA 503	Mus musculus	70-77
31786862-0	2019	Inhibition of cancer cell growth by oleanolic acid in multidrug resistant liver carcinoma is mediated via suppression of cancer cell migration and invasion, mitochondrial apoptosis, G2/M cell cycle arrest and deactivation of JNK/p38 signalling pathway.	Oleanolic Acid	36-50	mitogen-activated protein kinase 14	Homo sapiens	229-232
31786862-14	2019	Oleanolic acid also suppressed the migration and invasion of the liver cancer cells via blocking of the JNK/p38 signalling pathway.	Oleanolic Acid	0-14	mitogen-activated protein kinase 14	Homo sapiens	108-111
31153932-8	2019	Taken together, this study demonstrated that oleanolic acid produced the antidepressant-like effects, which might be related to the down-regulation of SGK1.	Oleanolic Acid	45-59	serum/glucocorticoid regulated kinase 1	Mus musculus	151-155
31153932-2	2019	Considering that serine/threonine-protein kinase 1 (SGK1) is involved in stress response, the present study aimed to evaluate the involvement of SGK1 in the antidepressant-like effects of oleanolic acid in depression-like mice induced by long term corticosterone (CORT) injection.	Oleanolic Acid	188-202	serum/glucocorticoid regulated kinase 1	Mus musculus	52-56
31153932-2	2019	Considering that serine/threonine-protein kinase 1 (SGK1) is involved in stress response, the present study aimed to evaluate the involvement of SGK1 in the antidepressant-like effects of oleanolic acid in depression-like mice induced by long term corticosterone (CORT) injection.	Oleanolic Acid	188-202	serum/glucocorticoid regulated kinase 1	Mus musculus	145-149
31153932-5	2019	In addition, oleanolic acid decreased SGK1 and activated BDNF-AKT/mTOR signaling in the hippocampus of CORT-induced animals.	Oleanolic Acid	13-27	serum/glucocorticoid regulated kinase 1	Mus musculus	38-42
31153932-5	2019	In addition, oleanolic acid decreased SGK1 and activated BDNF-AKT/mTOR signaling in the hippocampus of CORT-induced animals.	Oleanolic Acid	13-27	brain derived neurotrophic factor	Mus musculus	57-61
31153932-5	2019	In addition, oleanolic acid decreased SGK1 and activated BDNF-AKT/mTOR signaling in the hippocampus of CORT-induced animals.	Oleanolic Acid	13-27	thymoma viral proto-oncogene 1	Mus musculus	62-65
31153932-5	2019	In addition, oleanolic acid decreased SGK1 and activated BDNF-AKT/mTOR signaling in the hippocampus of CORT-induced animals.	Oleanolic Acid	13-27	mechanistic target of rapamycin kinase	Mus musculus	66-70
31316298-0	2019	Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy.	Oleanolic Acid	54-68	high mobility group box 1	Mus musculus	94-99
31441181-0	2019	Protosappanin-A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT-mTOR signaling.	Oleanolic Acid	20-34	AKT serine/threonine kinase 1	Homo sapiens	98-101
31441181-0	2019	Protosappanin-A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT-mTOR signaling.	Oleanolic Acid	20-34	mechanistic target of rapamycin kinase	Homo sapiens	102-106
31248593-2	2019	Bardoxolone (Bard), a synthetic triterpenoid based on natural product oleanolic acid, is one of the most potent Nrf2 activator.	Oleanolic Acid	70-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116
30901738-0	2019	The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-kappaB acetylation.	Oleanolic Acid	25-39	sirtuin 1	Mus musculus	117-122
30901738-0	2019	The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-kappaB acetylation.	Oleanolic Acid	25-39	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-145
30599410-0	2019	Ursolic and oleanolic acid derivatives with cholinesterase inhibiting potential.	Oleanolic Acid	12-26	butyrylcholinesterase	Homo sapiens	44-58
30677669-0	2019	Synthesis and biological evaluation of novel oleanolic acid analogues as potential alpha-glucosidase inhibitors.	Oleanolic Acid	45-59	sucrase isomaltase (alpha-glucosidase)	Mus musculus	83-100
30677669-2	2019	In this study, a series of novel oleanolic acid analogues against alpha-glucosidase were synthesized and their biological activities were evaluated in vitro and in vivo.	Oleanolic Acid	33-47	sucrase isomaltase (alpha-glucosidase)	Mus musculus	66-83
30678182-0	2019	Long-Term Impact of Neonatal Intake of Oleanolic Acid on the Expression of AMP-Activated Protein Kinase, Adiponectin and Inflammatory Cytokines in Rats Fed with a High Fructose Diet.	Oleanolic Acid	39-53	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	105-116
30496739-0	2019	Oleanolic acid promotes orofacial antinociception in adult zebrafish (Danio rerio) through TRPV1 receptors.	Oleanolic Acid	0-14	transient receptor potential cation channel, subfamily V, member 1	Danio rerio	91-96
30496739-10	2019	In line with in vivo experiments, docking studies indicated that oleanolic acid may interact with TRPV1.	Oleanolic Acid	65-79	transient receptor potential cation channel, subfamily V, member 1	Danio rerio	98-103
30496739-11	2019	Results confirm the potential pharmacological relevance of oleanolic acid as an inhibitor of orofacial nociception mediated by TRPV1.	Oleanolic Acid	59-73	transient receptor potential cation channel, subfamily V, member 1	Danio rerio	127-132
30409782-3	2019	The current study reveals that oleanolic acid (OLA) affects murine beta-cell function by TGR5 activation.	Oleanolic Acid	31-45	G protein-coupled bile acid receptor 1	Mus musculus	89-93
30409782-3	2019	The current study reveals that oleanolic acid (OLA) affects murine beta-cell function by TGR5 activation.	Oleanolic Acid	47-50	G protein-coupled bile acid receptor 1	Mus musculus	89-93
30678182-0	2019	Long-Term Impact of Neonatal Intake of Oleanolic Acid on the Expression of AMP-Activated Protein Kinase, Adiponectin and Inflammatory Cytokines in Rats Fed with a High Fructose Diet.	Oleanolic Acid	39-53	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	75-103
30678182-5	2019	In this study, the long-term effects of neonatal intake of oleanolic acid (OA) on the AMPK gene, genes associated with glucose transport and lipid metabolism, adiponectin levels, and inflammatory biomarkers in rats fed with a high fructose diet were investigated.	Oleanolic Acid	59-73	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	86-90
30240794-0	2018	Role of Oleanolic acid in maintaining BBB integrity by targeting p38MAPK/VEGF/Src signaling pathway in rat model of subarachnoid hemorrhage.	Oleanolic Acid	8-22	vascular endothelial growth factor A	Rattus norvegicus	73-77
31142251-9	2019	Furthermore, oleanolic acid acts on TGR5 - the cholic acid receptor, as an agonist of cholic acid.	Oleanolic Acid	13-27	G protein-coupled bile acid receptor 1	Homo sapiens	36-40
30297361-0	2019	Oleanolic Acid Inhibits Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Promoting iNOS Dimerization.	Oleanolic Acid	0-14	nitric oxide synthase 2, inducible	Mus musculus	99-103
30297361-4	2019	We further proved that inducible nitric oxide synthase (iNOS) may be the potential target of oleanolic acid.	Oleanolic Acid	93-107	nitric oxide synthase 2, inducible	Mus musculus	23-54
30297361-4	2019	We further proved that inducible nitric oxide synthase (iNOS) may be the potential target of oleanolic acid.	Oleanolic Acid	93-107	nitric oxide synthase 2, inducible	Mus musculus	56-60
30297361-5	2019	We confirmed that oleanolic acid could promote the dimerization of iNOS, activating it, and subsequently increasing the production of nitric oxide.	Oleanolic Acid	18-32	nitric oxide synthase 2, inducible	Mus musculus	67-71
30542007-0	2019	Decreased Plasma Octanoylated Ghrelin Levels in Mice by Oleanolic Acid.	Oleanolic Acid	56-70	ghrelin	Mus musculus	30-37
30542007-4	2019	We previously established an AGS-GHRL8 cell line that produces octanoylated ghrelin in the presence of octanoic acid, and found that oleanolic acid suppresses octanoylated ghrelin production in AGS-GHRL8 cells.	Oleanolic Acid	133-147	ghrelin	Mus musculus	172-179
30542007-6	2019	Oral administration of oleanolic acid for seven days (20 or 40 mg/kg) reduced plasma octanoylated ghrelin levels and body weight gain in the standard diet-fed mice but not in other two diet-fed mice.	Oleanolic Acid	23-37	ghrelin	Mus musculus	98-105
30542007-10	2019	Hence, the inhibitory effect of oleanolic acid on octanoylated ghrelin production may not be related to the decrease in octanoyl-CoA.	Oleanolic Acid	32-46	ghrelin	Mus musculus	63-70
30240794-0	2018	Role of Oleanolic acid in maintaining BBB integrity by targeting p38MAPK/VEGF/Src signaling pathway in rat model of subarachnoid hemorrhage.	Oleanolic Acid	8-22	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	78-81
29966735-8	2018	OLA also influenced the expression of mRNA encoding pro-inflammatory cytokines (IL-1beta and IL-6) and some lipogenic genes (PPARalpha, SREBP1, FAS, ChREBP, and G6Pase) in liver and adipose tissue.	Oleanolic Acid	0-3	interleukin 1 beta	Mus musculus	80-88
30351048-0	2018	Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis.	Oleanolic Acid	0-14	nuclear receptor subfamily 1 group I member 2	Homo sapiens	51-70
30106101-0	2018	Oleanolic acid protects against oxidative stress-induced human umbilical vein endothelial cell injury by activating AKT/eNOS signaling.	Oleanolic Acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	116-119
29966735-8	2018	OLA also influenced the expression of mRNA encoding pro-inflammatory cytokines (IL-1beta and IL-6) and some lipogenic genes (PPARalpha, SREBP1, FAS, ChREBP, and G6Pase) in liver and adipose tissue.	Oleanolic Acid	0-3	interleukin 6	Mus musculus	93-97
29966735-8	2018	OLA also influenced the expression of mRNA encoding pro-inflammatory cytokines (IL-1beta and IL-6) and some lipogenic genes (PPARalpha, SREBP1, FAS, ChREBP, and G6Pase) in liver and adipose tissue.	Oleanolic Acid	0-3	peroxisome proliferator activated receptor alpha	Mus musculus	125-134
29966735-8	2018	OLA also influenced the expression of mRNA encoding pro-inflammatory cytokines (IL-1beta and IL-6) and some lipogenic genes (PPARalpha, SREBP1, FAS, ChREBP, and G6Pase) in liver and adipose tissue.	Oleanolic Acid	0-3	sterol regulatory element binding transcription factor 1	Mus musculus	136-142
29966735-8	2018	OLA also influenced the expression of mRNA encoding pro-inflammatory cytokines (IL-1beta and IL-6) and some lipogenic genes (PPARalpha, SREBP1, FAS, ChREBP, and G6Pase) in liver and adipose tissue.	Oleanolic Acid	0-3	MLX interacting protein-like	Mus musculus	149-155
29966735-8	2018	OLA also influenced the expression of mRNA encoding pro-inflammatory cytokines (IL-1beta and IL-6) and some lipogenic genes (PPARalpha, SREBP1, FAS, ChREBP, and G6Pase) in liver and adipose tissue.	Oleanolic Acid	0-3	glucose-6-phosphatase, catalytic	Mus musculus	161-167
30037214-0	2018	Oleanolic Acids Inhibit Vascular Endothelial Growth Factor Receptor 2 Signaling in Endothelial Cells: Implication for Anti-Angiogenic Therapy.	Oleanolic Acid	0-15	vascular endothelial growth factor A	Mus musculus	24-58
30037214-4	2018	Oleanolic acid was verified as a VEGFR-2 binding chemical from anticancer herbs with similar binding affinity as a reference drug in the Protein Data Bank (PDB) entry 3CJG of model A coordination.	Oleanolic Acid	0-14	kinase insert domain protein receptor	Mus musculus	33-40
30037214-5	2018	Oleanolic acid effectively inhibited VEGF-induced VEGFR-2 activation and angiogenesis in HU-VECs without cytotoxicity.	Oleanolic Acid	0-14	vascular endothelial growth factor A	Mus musculus	37-41
30037214-5	2018	Oleanolic acid effectively inhibited VEGF-induced VEGFR-2 activation and angiogenesis in HU-VECs without cytotoxicity.	Oleanolic Acid	0-14	kinase insert domain protein receptor	Mus musculus	50-57
29879443-0	2018	Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance via HNF1b-mediated regulation of redox and PPARgamma signaling.	Oleanolic Acid	0-14	HNF1 homeobox B	Mus musculus	76-81
29879443-0	2018	Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance via HNF1b-mediated regulation of redox and PPARgamma signaling.	Oleanolic Acid	0-14	peroxisome proliferator activated receptor gamma	Mus musculus	115-124
29908469-10	2018	Among the six analytes, ginsenoside Rb1 showed slowest elimination from plasma with a t1/2z of 16.00 h, while that of the others were between 1.72 and 5.62 h. In conclusion, the developed method was successfully used to simultaneously analyze major oleanolic acid-type and damarane-type saponins of RPJ in rat plasma after oral administration.	Oleanolic Acid	249-263	RB transcriptional corepressor 1	Rattus norvegicus	36-39