PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27347182-1	2016	O-linked N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation), a dynamic post-translational modification of nuclear and cytoplasmic proteins, may have a critical role in the regulation of biological cell processes and human cancer.	o-glcnacylation	55-70	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	30-38
27078700-0	2016	Roles of O-GlcNAcylation on amyloid-beta precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer"s disease.	o-glcnacylation	9-24	amyloid beta precursor protein	Homo sapiens	28-58
26840030-5	2016	O-GlcNAcylation regulated the subcellular location of PKAcalpha and PKAcbeta and enhanced their kinase activity.	o-glcnacylation	0-15	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	54-63
26840030-5	2016	O-GlcNAcylation regulated the subcellular location of PKAcalpha and PKAcbeta and enhanced their kinase activity.	o-glcnacylation	0-15	protein kinase cAMP-activated catalytic subunit beta	Rattus norvegicus	68-76
26840030-7	2016	In contrast, in rat and mouse brains, downregulation of O-GlcNAcylation caused decreases in the phosphorylation of CREB at Ser133 and of tau at Ser214, but not at Thr205.	o-glcnacylation	56-71	cAMP responsive element binding protein 1	Mus musculus	115-119
26840030-8	2016	Reduction in O-GlcNAcylation through intracerebroventricular injection of 6-diazo-5-oxo-l-norleucine (DON), the inhibitor of glutamine fructose-6-phosphate amidotransferase, suppressed PKA-CREB signaling and impaired learning and memory in mice.	o-glcnacylation	13-28	cAMP responsive element binding protein 1	Mus musculus	189-193
24859566-10	2014	While OGA inhibitors are already being tested for AD treatment, our results provide a strong indication that the general subject of O-GlcNAcylation and specifically its regulation by OGA and OGT in AD need further investigation to conclusively elucidate its potential role in AD pathogenesis and treatment.	o-glcnacylation	132-147	O-GlcNAcase	Homo sapiens	6-9
25627821-6	2015	Augmentation of O-GlcNAcylation with high glucose (33 mM) was associated with diminished basal and maximal cardiomyocyte respiration, a decreased mitochondrial reserve capacity and lower Complex II-dependent respiration (P<0.05); however, pharmacological or genetic modulation of O-GlcNAc modifications under normal or high glucose conditions showed few significant effects on mitochondrial respiration, suggesting that O-GlcNAc does not play a major role in regulating cardiomyocyte mitochondrial function.	o-glcnacylation	16-31	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	283-291
26640786-4	2015	O-GlcNAc status was assessed by Western blot under normal conditions and after modulation with 6-diazo-5-oxo-L-norleucine (DON) to decrease O-GlcNAcylation or O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenyl carbamate (PUGNAc) to increase O-GlcNAcylation.	o-glcnacylation	140-155	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-8
26640786-4	2015	O-GlcNAc status was assessed by Western blot under normal conditions and after modulation with 6-diazo-5-oxo-L-norleucine (DON) to decrease O-GlcNAcylation or O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenyl carbamate (PUGNAc) to increase O-GlcNAcylation.	o-glcnacylation	251-266	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-8
24859566-10	2014	While OGA inhibitors are already being tested for AD treatment, our results provide a strong indication that the general subject of O-GlcNAcylation and specifically its regulation by OGA and OGT in AD need further investigation to conclusively elucidate its potential role in AD pathogenesis and treatment.	o-glcnacylation	132-147	O-GlcNAcase	Homo sapiens	183-186
24859566-10	2014	While OGA inhibitors are already being tested for AD treatment, our results provide a strong indication that the general subject of O-GlcNAcylation and specifically its regulation by OGA and OGT in AD need further investigation to conclusively elucidate its potential role in AD pathogenesis and treatment.	o-glcnacylation	132-147	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	191-194
24444746-6	2014	Similarly, nuclear magnetic resonance studies demonstrated that O-GlcNAcylation only minimally perturbs the local structural and dynamic features of a tau fragment (residues 353-408) spanning the last microtubule binding repeat to the major GlcNAc-acceptor Ser400.	o-glcnacylation	64-79	microtubule associated protein tau	Homo sapiens	151-154
23580777-1	2013	O-GlcNAcylation is an inducible, highly dynamic and reversible post-translational modification, mediated by a unique enzyme named O-linked N-acetyl-d-glucosamine (O-GlcNAc) transferase (OGT).	o-glcnacylation	0-15	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	186-189
24035784-6	2014	METHODS: Human T lymphoblastic HPB-ALL cells were treated with the OGA inhibitor O-(2-acetamido-2-deoxy-d-glucopyranosylidene) amino-N-phenylcarbamate (PUGNAc), or with glucosamine (GlcN), to increase O-GlcNAcylation.	o-glcnacylation	201-216	O-GlcNAcase	Homo sapiens	67-70
23620203-5	2013	Stress-induced O-GlcNAcylation appears to promote cell/tissue survival by regulating a multitude of biological processes including: the phosphoinositide 3-kinase/Akt pathway, heat shock protein expression, calcium homeostasis, levels of reactive oxygen species, ER stress, protein stability, mitochondrial dynamics, and inflammation.	o-glcnacylation	15-30	AKT serine/threonine kinase 1	Homo sapiens	162-165
21182826-0	2011	O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-beta precursor protein (APP).	o-glcnacylation	0-15	amyloid beta precursor protein	Homo sapiens	62-92
22503002-7	2013	This is the first study to show the relationship between Abeta generation and O-GlcNAcylation in vivo.	o-glcnacylation	78-93	amyloid beta (A4) precursor protein	Mus musculus	57-62
21182826-3	2011	We also show that O-GlcNAcylation increases non-amyloidogenic alpha-secretase processing, resulting in increased levels of the neuroprotective sAPPalpha fragment and decreased Abeta secretion.	o-glcnacylation	18-33	amyloid beta precursor protein	Homo sapiens	176-181
18671940-0	2008	O-GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau.	o-glcnacylation	0-15	microtubule associated protein tau	Homo sapiens	99-102
21391816-7	2011	Abnormal amounts of O-GlcNAcylation underlie the etiology of insulin resistance and glucose toxicity in diabetes, and this type of modification plays a direct role in neurodegenerative disease.	o-glcnacylation	20-35	insulin	Homo sapiens	61-68
18671940-3	2008	And O-GlcNAcylation may regulate phosphorylation of tau in a site-specific manner.	o-glcnacylation	4-19	microtubule associated protein tau	Homo sapiens	52-55
18671940-8	2008	This modulation of O-GlcNAcylation on tau aggregation implies a new perspective of tau pathology.	o-glcnacylation	19-34	microtubule associated protein tau	Homo sapiens	38-41
18671940-8	2008	This modulation of O-GlcNAcylation on tau aggregation implies a new perspective of tau pathology.	o-glcnacylation	19-34	microtubule associated protein tau	Homo sapiens	83-86
33801653-4	2021	To maintain homeostasis of cellular O-GlcNAcylation, there exists feedback regulation of OGT and OGA expression responding to fluctuations of O-GlcNAc levels; yet, little is known about the molecular mechanisms involved.	o-glcnacylation	36-51	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	89-92
15249677-0	2004	O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer"s disease.	o-glcnacylation	0-15	microtubule associated protein tau	Homo sapiens	45-48
15249677-5	2004	O-GlcNAcylation regulated phosphorylation of tau in a site-specific manner both in vitro and in vivo.	o-glcnacylation	0-15	microtubule associated protein tau	Homo sapiens	45-48
33789105-1	2021	Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an important function in diverse biological processes and diseases.	o-glcnacylation	44-59	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-3
33801653-4	2021	To maintain homeostasis of cellular O-GlcNAcylation, there exists feedback regulation of OGT and OGA expression responding to fluctuations of O-GlcNAc levels; yet, little is known about the molecular mechanisms involved.	o-glcnacylation	36-51	O-GlcNAcase	Homo sapiens	97-100
34941261-8	2022	We find that O-GlcNAcylation at Ser473 and phosphorylation at Tyr474 can also partially increase Akt"s kinase activity toward both peptide and protein substrates.	o-glcnacylation	13-28	AKT serine/threonine kinase 1	Homo sapiens	97-100
33814439-10	2021	Enhancement of O-GlcNAcylation to moderate levels by using low-dose OGA inhibitor in ICV-STZ mice prevented STZ-induced body weight loss, rescued cognitive impairments, and restored AD-like pathologies, including hyperphosphorylation of tau and abnormalities in synaptic proteins and neuroinflammation.	o-glcnacylation	15-30	O-GlcNAcase	Mus musculus	68-71
34907035-7	2022	Therefore, O-GlcNAcylation of Blimp-1 in lymphocytes may serve as a new target for the treatment of metastatic breast cancer.	o-glcnacylation	11-26	PR/SET domain 1	Homo sapiens	30-37
34785590-1	2021	Aberrant O-GlcNAcylation, a protein posttranslational modification defined by the O-linked attachment of the monosaccharide N-acetylglucosamine (O-GlcNAc), has been implicated in neurodegenerative diseases.	o-glcnacylation	9-24	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	109-153
34418053-0	2021	O-GlcNAcylation is essential for rapid Pomc expression and cell proliferation in corticotropic tumor cells.	o-glcnacylation	0-15	proopiomelanocortin	Homo sapiens	39-43
34371035-2	2021	Several post-translational modifications (PTMs)-including autophosphorylation, oxidation, S-nitrosylation, and O-GlcNAcylation-have been shown to trap CaMKII in an autonomously active state.	o-glcnacylation	111-126	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	151-157
34650217-6	2021	Mechanistically, PCK1 depletion suppressed KAT5 ubiquitination by increasing its O-GlcNAcylation, thereby stabilizing KAT5.	o-glcnacylation	81-96	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	17-21
34650217-6	2021	Mechanistically, PCK1 depletion suppressed KAT5 ubiquitination by increasing its O-GlcNAcylation, thereby stabilizing KAT5.	o-glcnacylation	81-96	K(lysine) acetyltransferase 5	Mus musculus	43-47
34940409-0	2021	O-GlcNAcylation Inhibits Endocytosis of Amyloid Precursor Protein by Decreasing Its Localization in Lipid Raft Microdomains.	o-glcnacylation	0-15	amyloid beta precursor protein	Homo sapiens	40-65
34939084-0	2022	O-GlcNAcylation increases PYGL activity by promoting phosphorylation.	o-glcnacylation	0-15	glycogen phosphorylase L	Homo sapiens	26-30
34939084-10	2022	Thus, O-GlcNAcylation of PYGL positively regulated pSer15 and therefore its enzymatic activity.	o-glcnacylation	6-21	glycogen phosphorylase L	Homo sapiens	25-29
34605247-0	2021	Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity.	o-glcnacylation	50-65	nitric oxide synthase 3	Homo sapiens	45-49
34745848-4	2021	The amino acid succession of EZH2 protein makes it appropriate for covalent modifications, like phosphorylation, acetylation, O-GlcNAcylation, methylation, ubiquitination, and sumoylation.	o-glcnacylation	126-141	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
34605247-0	2021	Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity.	o-glcnacylation	50-65	nitric oxide synthase 3	Homo sapiens	77-81
34291417-7	2021	The upregulation of FOXA2 expression induced the synthesis of intracellular UDP-GlcNAc, which is the sugar substrate of O-GlcNAcylation produced by the HBP.	o-glcnacylation	120-135	forkhead box A2	Homo sapiens	20-25
34837015-5	2021	Furthermore, altered brain O-GlcNAcylation is associated with either the etiology or pathology of numerous neurodegenerative diseases, while the manipulation of O-GlcNAc exerts neuroprotective effects against these diseases.	o-glcnacylation	27-42	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	161-169
34722537-0	2021	Regulation of Nuclear Factor-kappaB Function by O-GlcNAcylation in Inflammation and Cancer.	o-glcnacylation	48-63	nuclear factor kappa B subunit 1	Homo sapiens	14-35
34503365-5	2021	Objective: To elucidate the physiological function of PRMT5 and the mechanism underlying its role in regulating cardiac O-GlcNAcylation and homeostasis.	o-glcnacylation	120-135	protein arginine N-methyltransferase 5	Mus musculus	54-59
34722537-5	2021	O-GlcNAcylation is a dynamic posttranslational modification that controls NF-kappaB-dependent transactivation.	o-glcnacylation	0-15	nuclear factor kappa B subunit 1	Homo sapiens	74-83
34712646-4	2021	We also provided evidence that this labeling is dependent on not only the enzymes of OGT responsible for O-GlcNAcylation but also the enzymes of GALT and GALE in the Leloir pathway.	o-glcnacylation	105-120	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	85-88
34712646-4	2021	We also provided evidence that this labeling is dependent on not only the enzymes of OGT responsible for O-GlcNAcylation but also the enzymes of GALT and GALE in the Leloir pathway.	o-glcnacylation	105-120	galactose-1-phosphate uridylyltransferase	Homo sapiens	145-149
34712646-4	2021	We also provided evidence that this labeling is dependent on not only the enzymes of OGT responsible for O-GlcNAcylation but also the enzymes of GALT and GALE in the Leloir pathway.	o-glcnacylation	105-120	UDP-galactose-4-epimerase	Homo sapiens	154-158
34487576-0	2021	Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O-GlcNAcylation of CDK5.	o-glcnacylation	94-109	cyclin dependent kinase 5	Homo sapiens	113-117
35316768-8	2022	These results suggest that Mef2d negatively regulates insulin secretion through O-GlcNAcylation.	o-glcnacylation	80-95	myocyte enhancer factor 2D	Mus musculus	27-32
34312767-6	2021	Suppression of O-GlcNAcylation by the glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitor, 6-diazo-5-oxo-L-norleucine (DON), or OGT inhibitor, OSMI-1, impaired memory function, and inhibited FC-induced PKA/CREB activation.	o-glcnacylation	15-30	glutamine fructose-6-phosphate transaminase 1	Mus musculus	38-85
34312767-6	2021	Suppression of O-GlcNAcylation by the glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitor, 6-diazo-5-oxo-L-norleucine (DON), or OGT inhibitor, OSMI-1, impaired memory function, and inhibited FC-induced PKA/CREB activation.	o-glcnacylation	15-30	glutamine fructose-6-phosphate transaminase 1	Mus musculus	87-91
34312767-6	2021	Suppression of O-GlcNAcylation by the glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitor, 6-diazo-5-oxo-L-norleucine (DON), or OGT inhibitor, OSMI-1, impaired memory function, and inhibited FC-induced PKA/CREB activation.	o-glcnacylation	15-30	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	141-144
34312767-6	2021	Suppression of O-GlcNAcylation by the glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitor, 6-diazo-5-oxo-L-norleucine (DON), or OGT inhibitor, OSMI-1, impaired memory function, and inhibited FC-induced PKA/CREB activation.	o-glcnacylation	15-30	cAMP responsive element binding protein 1	Mus musculus	219-223
34588426-9	2021	Importantly, we found that CA can reduce YAP expression and O-GlcNAcylation by inhibiting the activity of CDK19.	o-glcnacylation	60-75	cyclin dependent kinase 19	Homo sapiens	106-111
34646384-7	2021	OGT and OGA, unique enzymes that regulate intracellular O-GlcNAcylation, were also indispensable.	o-glcnacylation	56-71	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-3
34646384-7	2021	OGT and OGA, unique enzymes that regulate intracellular O-GlcNAcylation, were also indispensable.	o-glcnacylation	56-71	O-GlcNAcase	Homo sapiens	8-11
34354953-12	2021	It shunted the glucose flux towards the pentose phosphate pathway (PPP) by activating G6PD through OGT-promoted O-GlcNAcylation.	o-glcnacylation	112-127	glucose-6-phosphate dehydrogenase	Homo sapiens	86-90
34354953-12	2021	It shunted the glucose flux towards the pentose phosphate pathway (PPP) by activating G6PD through OGT-promoted O-GlcNAcylation.	o-glcnacylation	112-127	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	99-102
34354953-13	2021	The expression of OGT was positively correlated with Pol iota expression and O-GlcNAcylation.	o-glcnacylation	77-92	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	18-21
34354953-16	2021	In conclusion, Pol iota activates G6PD through Erk-OGT-induced O-GlcNAcylation to promote the proliferation and progression of ESCC, supporting the notion that Pol iota is a potential biomarker and therapeutic target of ESCC.	o-glcnacylation	63-78	DNA polymerase mu	Homo sapiens	15-23
34354953-16	2021	In conclusion, Pol iota activates G6PD through Erk-OGT-induced O-GlcNAcylation to promote the proliferation and progression of ESCC, supporting the notion that Pol iota is a potential biomarker and therapeutic target of ESCC.	o-glcnacylation	63-78	glucose-6-phosphate dehydrogenase	Homo sapiens	34-38
34354953-16	2021	In conclusion, Pol iota activates G6PD through Erk-OGT-induced O-GlcNAcylation to promote the proliferation and progression of ESCC, supporting the notion that Pol iota is a potential biomarker and therapeutic target of ESCC.	o-glcnacylation	63-78	mitogen-activated protein kinase 1	Homo sapiens	47-50
34354953-16	2021	In conclusion, Pol iota activates G6PD through Erk-OGT-induced O-GlcNAcylation to promote the proliferation and progression of ESCC, supporting the notion that Pol iota is a potential biomarker and therapeutic target of ESCC.	o-glcnacylation	63-78	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	51-54
34354953-16	2021	In conclusion, Pol iota activates G6PD through Erk-OGT-induced O-GlcNAcylation to promote the proliferation and progression of ESCC, supporting the notion that Pol iota is a potential biomarker and therapeutic target of ESCC.	o-glcnacylation	63-78	DNA polymerase mu	Homo sapiens	160-168
35637289-0	2022	O-GlcNAcylation modulates liquid-liquid phase separation of SynGAP/PSD-95.	o-glcnacylation	0-15	synaptic Ras GTPase activating protein 1	Rattus norvegicus	60-66
35637289-0	2022	O-GlcNAcylation modulates liquid-liquid phase separation of SynGAP/PSD-95.	o-glcnacylation	0-15	discs large MAGUK scaffold protein 4	Rattus norvegicus	67-73
34338261-3	2021	This review provides an extensive summary of the recent progress in probing O-GlcNAcylation using mainly chemical methods, with a special focus on discussing mechanistic insights and the structural role of O-GlcNAc at the molecular level.	o-glcnacylation	76-91	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	206-214
34391182-0	2021	OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.	o-glcnacylation	14-29	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-3
34391182-0	2021	OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.	o-glcnacylation	14-29	interleukin 6	Homo sapiens	76-80
34391182-0	2021	OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.	o-glcnacylation	14-29	signal transducer and activator of transcription 3	Homo sapiens	81-86
34441396-2	2021	High levels of O-GlcNAcylation (O-GlcNAc) and pyruvate kinase isoenzyme M2 (PKM2) are associated with malignancy in BC; however, the association with the recurrence risk remains unclear.	o-glcnacylation	15-30	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	32-40
34155345-0	2021	OGT regulated O-GlcNAcylation promotes papillary thyroid cancer malignancy via activating YAP.	o-glcnacylation	14-29	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-3
34155345-0	2021	OGT regulated O-GlcNAcylation promotes papillary thyroid cancer malignancy via activating YAP.	o-glcnacylation	14-29	Yes1 associated transcriptional regulator	Homo sapiens	90-93
34135314-1	2021	Accumulated evidence shows that OGT-mediated O-GlcNAcylation plays an important role in response to DNA damage repair.	o-glcnacylation	45-60	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	32-35
34074792-6	2021	We also quantify specific side-chain and backbone interactions within condensed CAPRIN1 that define critical sequences for phase separation and that are reduced by O-GlcNAcylation known to occur during cell cycle and stress.	o-glcnacylation	164-179	cell cycle associated protein 1	Homo sapiens	80-87
35358489-10	2022	As mechanism we have found that YAP1 undergoes reduced ser127 phosphorylation as well as extensive O-GlcNAcylation mediated activation under hyperglycemia.	o-glcnacylation	99-114	Yes1 associated transcriptional regulator	Homo sapiens	32-36
35290457-4	2022	Mass spectrometric analysis of NOTCH1 fragments expressed in HEK293T cells revealed that several EGF domains with putative O-GlcNAcylation sites were hardly modified with O-GlcNAc.	o-glcnacylation	123-138	epidermal growth factor	Homo sapiens	97-100
35296731-0	2022	Increased O-GlcNAcylation promotes IGF-1 receptor/PhosphatidyI Inositol-3 kinase/Akt pathway in cervical cancer cells.	o-glcnacylation	10-25	insulin like growth factor 1 receptor	Homo sapiens	35-49
35131454-7	2022	Following STAT3 phosphorylation, existing STAT3 O-GlcNAcylation was antagonistically released.	o-glcnacylation	48-63	signal transducer and activator of transcription 3	Homo sapiens	42-47
35083852-0	2022	O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells.	o-glcnacylation	0-15	fatty acid synthase	Homo sapiens	25-44
35479087-6	2022	Chemical inhibition of O-GlcNAcylation using OSMI-1 was associated with a decreased expression of NK cell receptors (NKG2D, NKG2A, NKp44), cytokines (tumor necrosis factor (TNF)-alpha, interferon (IFN-gamma)), granulysin, soluble Fas ligand, perforin, and granzyme B in NK cells.	o-glcnacylation	23-38	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	117-122
35479087-6	2022	Chemical inhibition of O-GlcNAcylation using OSMI-1 was associated with a decreased expression of NK cell receptors (NKG2D, NKG2A, NKp44), cytokines (tumor necrosis factor (TNF)-alpha, interferon (IFN-gamma)), granulysin, soluble Fas ligand, perforin, and granzyme B in NK cells.	o-glcnacylation	23-38	killer cell lectin-like receptor subfamily C, member 1	Mus musculus	124-129
35479087-6	2022	Chemical inhibition of O-GlcNAcylation using OSMI-1 was associated with a decreased expression of NK cell receptors (NKG2D, NKG2A, NKp44), cytokines (tumor necrosis factor (TNF)-alpha, interferon (IFN-gamma)), granulysin, soluble Fas ligand, perforin, and granzyme B in NK cells.	o-glcnacylation	23-38	tumor necrosis factor	Mus musculus	150-183
35479087-6	2022	Chemical inhibition of O-GlcNAcylation using OSMI-1 was associated with a decreased expression of NK cell receptors (NKG2D, NKG2A, NKp44), cytokines (tumor necrosis factor (TNF)-alpha, interferon (IFN-gamma)), granulysin, soluble Fas ligand, perforin, and granzyme B in NK cells.	o-glcnacylation	23-38	interferon gamma	Mus musculus	197-206
35479087-6	2022	Chemical inhibition of O-GlcNAcylation using OSMI-1 was associated with a decreased expression of NK cell receptors (NKG2D, NKG2A, NKp44), cytokines (tumor necrosis factor (TNF)-alpha, interferon (IFN-gamma)), granulysin, soluble Fas ligand, perforin, and granzyme B in NK cells.	o-glcnacylation	23-38	granzyme B	Mus musculus	256-266
35131454-2	2022	Activation of STAT3 requires its phosphorylated form, and STAT3 can also be post-translationally modified by O-GlcNAcylation.	o-glcnacylation	109-124	signal transducer and activator of transcription 3	Homo sapiens	14-19
35131454-2	2022	Activation of STAT3 requires its phosphorylated form, and STAT3 can also be post-translationally modified by O-GlcNAcylation.	o-glcnacylation	109-124	signal transducer and activator of transcription 3	Homo sapiens	58-63
35131454-4	2022	We observed, based on chemical enzyme labeling and click chemistry methods in combination with mass spectrometric analysis, that O-GlcNAcylation of STAT3 is significantly reduced under hypoxia.	o-glcnacylation	129-144	signal transducer and activator of transcription 3	Homo sapiens	148-153
35131454-7	2022	Following STAT3 phosphorylation, existing STAT3 O-GlcNAcylation was antagonistically released.	o-glcnacylation	48-63	signal transducer and activator of transcription 3	Homo sapiens	10-15
35625551-8	2022	However, global O-GlcNAcylation was found to decrease in differentiated cells and the extracellular localization of galectin-3 accompanies these changes.	o-glcnacylation	16-31	galectin 3	Homo sapiens	116-126
35422493-0	2022	O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGgamma interaction.	o-glcnacylation	0-15	sirtuin 7	Homo sapiens	96-101
35422493-0	2022	O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGgamma interaction.	o-glcnacylation	0-15	proteasome activator subunit 3	Homo sapiens	102-110
35296731-0	2022	Increased O-GlcNAcylation promotes IGF-1 receptor/PhosphatidyI Inositol-3 kinase/Akt pathway in cervical cancer cells.	o-glcnacylation	10-25	AKT serine/threonine kinase 1	Homo sapiens	81-84
34469899-1	2022	Several studies have demonstrated a role of O-GlcNAcylation (O-GlcNAc) in tumorigenesis of various carcinomas by modification of tumor-associated proteins.	o-glcnacylation	44-59	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	61-69
33651993-10	2021	It is suggested that the acute cold exposure of piglets induced a sequential change in the level of O-GlcNAcylation, which may be one of the factors mediating liver cell apoptosis and glucose metabolism regulation by the O-GlcNAc/AKT pathway.	o-glcnacylation	100-115	AKT serine/threonine kinase 1	Homo sapiens	230-233
35499042-11	2022	Specifically, elevated O-GlcNAcylation increased glucose uptake via glucose transporter 1 (GLUT1) leading to glucose metabolic flow into the pentose phosphate pathways and HBP, which regulate the metabolic reprogramming of endometrial cells.	o-glcnacylation	23-38	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	68-89
35499042-11	2022	Specifically, elevated O-GlcNAcylation increased glucose uptake via glucose transporter 1 (GLUT1) leading to glucose metabolic flow into the pentose phosphate pathways and HBP, which regulate the metabolic reprogramming of endometrial cells.	o-glcnacylation	23-38	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	91-96
33915326-8	2021	Furthermore, inhibition of O-GlcNAcylation via 6-diazo-5-oxo-l-norleucine (DON) apparently increased insulin-induced Akt phosphorylation and restored its cardioprotective response against reperfusion injury in palmitate-induced insulin-resistant H9c2 cells.	o-glcnacylation	27-42	AKT serine/threonine kinase 1	Rattus norvegicus	117-120
34046694-8	2021	These results indicate that FASN is under a dual control of O-GlcNAcylation and mTOR pathways.	o-glcnacylation	60-75	fatty acid synthase	Mus musculus	28-32
33544938-5	2021	Using correlation and co-immunoprecipitation analyses, we further identify c-Myc as a direct downstream targets of O-GlcNAcylation in MBs/MKs and provide compelling evidence on the regulation of platelets by novel O-GlcNAc/c-Myc axis.	o-glcnacylation	115-130	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	75-80
34050207-1	2021	O-GlcNAcylation, an energy-sensitive posttranslational modification, can regulate the activity of endothelial nitric oxide synthase (eNOS).	o-glcnacylation	0-15	nitric oxide synthase 3	Homo sapiens	98-131
34050207-1	2021	O-GlcNAcylation, an energy-sensitive posttranslational modification, can regulate the activity of endothelial nitric oxide synthase (eNOS).	o-glcnacylation	0-15	nitric oxide synthase 3	Homo sapiens	133-137
33731348-2	2021	We show that GREB1, an ERalpha-inducible enzyme, catalyzes O-GlcNAcylation of ERalpha at residues T553/S554, which stabilizes ERalpha protein by inhibiting association with the ubiquitin ligase ZNF598.	o-glcnacylation	59-74	gene regulated by estrogen in breast cancer protein	Mus musculus	13-18
33863873-6	2021	With YAP knockdown or YAP-T241 mutation, the increased sensitivity to ferroptosis induced by O-GlcNAcylation was abolished.	o-glcnacylation	93-108	Yes1 associated transcriptional regulator	Homo sapiens	22-25
33690219-7	2021	Meanwhile, deletion of PCK1 also resulted in AMPK-GFAT1 axis inactivation promoting UDP-GlcNAc synthesis for elevated O-GlcNAcylation.	o-glcnacylation	118-133	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	23-27
33690219-7	2021	Meanwhile, deletion of PCK1 also resulted in AMPK-GFAT1 axis inactivation promoting UDP-GlcNAc synthesis for elevated O-GlcNAcylation.	o-glcnacylation	118-133	glutamine fructose-6-phosphate transaminase 1	Mus musculus	50-55
33843053-0	2021	O-GlcNAcylation promotes the migratory ability of hepatocellular carcinoma cells via regulating FOXA2 stability and transcriptional activity.	o-glcnacylation	0-15	forkhead box A2	Homo sapiens	96-101
33843053-7	2021	Although this modification did not affect FOXA2 nuclear localization capability, O-GlcNAcylation on FOXA2 was key for attenuating FOXA2-mediated transcription.	o-glcnacylation	81-96	forkhead box A2	Homo sapiens	100-105
33843053-7	2021	Although this modification did not affect FOXA2 nuclear localization capability, O-GlcNAcylation on FOXA2 was key for attenuating FOXA2-mediated transcription.	o-glcnacylation	81-96	forkhead box A2	Homo sapiens	100-105
33843053-8	2021	O-GlcNAcylation decreased the transcription of FOXA2 downstream target gene E-cadherin and it ultimately promoted O-GlcNAcylation-mediated HCC cell migration and invasion.	o-glcnacylation	0-15	forkhead box A2	Homo sapiens	47-52
33843053-8	2021	O-GlcNAcylation decreased the transcription of FOXA2 downstream target gene E-cadherin and it ultimately promoted O-GlcNAcylation-mediated HCC cell migration and invasion.	o-glcnacylation	0-15	cadherin 1	Homo sapiens	76-86
33995901-2	2021	Aberrant O-GlcNAcylation is related to insulin resistance, diabetic complications, cancer and neurodegenerative diseases.	o-glcnacylation	9-24	insulin	Homo sapiens	39-46
33550377-11	2021	Direct inhibition of O-GlcNAcylation via the OGT inhibitor, OSMI-1 (50 muM), also prevented proliferation, but only in GCs of small follicles.	o-glcnacylation	21-36	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	Bos taurus	45-48
33916244-4	2021	We will focus on the complex relationship between phosphorylation and O-GlcNAcylation in the regulation of the RNA Polymerase II (RNAP II) pre-initiation complex and the regulation of the carboxyl-terminal domain of RNAP II via the synchronous actions of OGT, OGA, and kinases.	o-glcnacylation	70-85	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	255-258
33916244-4	2021	We will focus on the complex relationship between phosphorylation and O-GlcNAcylation in the regulation of the RNA Polymerase II (RNAP II) pre-initiation complex and the regulation of the carboxyl-terminal domain of RNAP II via the synchronous actions of OGT, OGA, and kinases.	o-glcnacylation	70-85	O-GlcNAcase	Homo sapiens	260-263
33925313-3	2021	O-GlcNAcylation is essential for epigenetic regulation of gene expression through its action on Polycomb and Trithorax and COMPASS complexes.	o-glcnacylation	0-15	Polycomb	Drosophila melanogaster	96-104
33925313-3	2021	O-GlcNAcylation is essential for epigenetic regulation of gene expression through its action on Polycomb and Trithorax and COMPASS complexes.	o-glcnacylation	0-15	trithorax	Drosophila melanogaster	109-118
33863873-0	2021	O-GlcNAcylation enhances sensitivity to RSL3-induced ferroptosis via the YAP/TFRC pathway in liver cancer.	o-glcnacylation	0-15	Yes1 associated transcriptional regulator	Homo sapiens	73-76
33863873-0	2021	O-GlcNAcylation enhances sensitivity to RSL3-induced ferroptosis via the YAP/TFRC pathway in liver cancer.	o-glcnacylation	0-15	transferrin receptor	Homo sapiens	77-81
33863873-2	2021	YAP has been reported to play a pivotal role in controlling ferroptotic death, and the expression of YAP is enhanced and stabilized by O-GlcNAcylation.	o-glcnacylation	135-150	Yes1 associated transcriptional regulator	Homo sapiens	0-3
33863873-2	2021	YAP has been reported to play a pivotal role in controlling ferroptotic death, and the expression of YAP is enhanced and stabilized by O-GlcNAcylation.	o-glcnacylation	135-150	Yes1 associated transcriptional regulator	Homo sapiens	101-104
33863873-6	2021	With YAP knockdown or YAP-T241 mutation, the increased sensitivity to ferroptosis induced by O-GlcNAcylation was abolished.	o-glcnacylation	93-108	Yes1 associated transcriptional regulator	Homo sapiens	5-8
33782411-7	2021	Consistently, the O-GlcNAcylation level positively correlates with MTHFD2 and PD-L1 in pancreatic cancer patients.	o-glcnacylation	18-33	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	67-73
33782411-7	2021	Consistently, the O-GlcNAcylation level positively correlates with MTHFD2 and PD-L1 in pancreatic cancer patients.	o-glcnacylation	18-33	CD274 molecule	Homo sapiens	78-83
33731348-2	2021	We show that GREB1, an ERalpha-inducible enzyme, catalyzes O-GlcNAcylation of ERalpha at residues T553/S554, which stabilizes ERalpha protein by inhibiting association with the ubiquitin ligase ZNF598.	o-glcnacylation	59-74	estrogen receptor 1	Homo sapiens	23-30
33731348-2	2021	We show that GREB1, an ERalpha-inducible enzyme, catalyzes O-GlcNAcylation of ERalpha at residues T553/S554, which stabilizes ERalpha protein by inhibiting association with the ubiquitin ligase ZNF598.	o-glcnacylation	59-74	estrogen receptor 1 (alpha)	Mus musculus	78-85
33731348-2	2021	We show that GREB1, an ERalpha-inducible enzyme, catalyzes O-GlcNAcylation of ERalpha at residues T553/S554, which stabilizes ERalpha protein by inhibiting association with the ubiquitin ligase ZNF598.	o-glcnacylation	59-74	estrogen receptor 1 (alpha)	Mus musculus	78-85
33731348-2	2021	We show that GREB1, an ERalpha-inducible enzyme, catalyzes O-GlcNAcylation of ERalpha at residues T553/S554, which stabilizes ERalpha protein by inhibiting association with the ubiquitin ligase ZNF598.	o-glcnacylation	59-74	ring finger protein 123	Mus musculus	177-193
33731348-2	2021	We show that GREB1, an ERalpha-inducible enzyme, catalyzes O-GlcNAcylation of ERalpha at residues T553/S554, which stabilizes ERalpha protein by inhibiting association with the ubiquitin ligase ZNF598.	o-glcnacylation	59-74	zinc finger protein 598	Mus musculus	194-200
33515675-4	2021	We hypothesized that they could mediate PDAC progression by influencing NOTCH1 O-GlcNAcylation.	o-glcnacylation	79-94	notch receptor 1	Homo sapiens	72-78
33523877-6	2021	O-GlcNAcylation of RIPK3 suppresses phosphorylation of RIPK3 and its interaction with RIPK1.	o-glcnacylation	0-15	receptor-interacting serine-threonine kinase 3	Mus musculus	19-24
33488099-0	2021	O-GlcNAcylation Enhances NUSAP1 Stability and Promotes Bladder Cancer Aggressiveness.	o-glcnacylation	0-15	nucleolar and spindle associated protein 1	Homo sapiens	25-31
33523877-6	2021	O-GlcNAcylation of RIPK3 suppresses phosphorylation of RIPK3 and its interaction with RIPK1.	o-glcnacylation	0-15	receptor-interacting serine-threonine kinase 3	Mus musculus	55-60
33523877-6	2021	O-GlcNAcylation of RIPK3 suppresses phosphorylation of RIPK3 and its interaction with RIPK1.	o-glcnacylation	0-15	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	86-91
33523877-7	2021	Moreover, increased O-GlcNAcylation ameliorated AD pathology, including Abeta burden, neuronal loss, neuroinflammation, and damaged mitochondria and recovered the M2 phenotype and phagocytic activity of microglia.	o-glcnacylation	20-35	amyloid beta (A4) precursor protein	Mus musculus	72-77
33375613-7	2020	The potentiation of YY1 and GSK3beta by O-GlcNAcylation will drive changes in metabolism in tumours and tumour microenvironment cells in association with their regulation of the melatonergic pathway.	o-glcnacylation	40-55	YY1 transcription factor	Homo sapiens	20-23
33422108-6	2021	In this study, we identified that Drp1 is regulated by O-GlcNAcylation in AD models.	o-glcnacylation	55-70	dynamin 1-like	Mus musculus	34-38
33422108-10	2021	In addition, overexpression of O-GlcNAc defective Drp1 mutant (T585A and T586A) decreased Drp1 O-GlcNAcylation and Abeta-induced mitochondria fragmentation.	o-glcnacylation	95-110	dynamin 1-like	Mus musculus	50-54
33422108-10	2021	In addition, overexpression of O-GlcNAc defective Drp1 mutant (T585A and T586A) decreased Drp1 O-GlcNAcylation and Abeta-induced mitochondria fragmentation.	o-glcnacylation	95-110	dynamin 1-like	Mus musculus	90-94
33375613-7	2020	The potentiation of YY1 and GSK3beta by O-GlcNAcylation will drive changes in metabolism in tumours and tumour microenvironment cells in association with their regulation of the melatonergic pathway.	o-glcnacylation	40-55	glycogen synthase kinase 3 alpha	Homo sapiens	28-36
33317171-9	2020	Together, our study reveals that the modulation of O-GlcNAcylation by OGT inhibition regulates mTOR-dependent autophagy in rat cortical neurons.	o-glcnacylation	51-66	O-linked N-acetylglucosamine (GlcNAc) transferase	Rattus norvegicus	70-73
33317171-9	2020	Together, our study reveals that the modulation of O-GlcNAcylation by OGT inhibition regulates mTOR-dependent autophagy in rat cortical neurons.	o-glcnacylation	51-66	mechanistic target of rapamycin kinase	Rattus norvegicus	95-99
33231560-10	2020	Our study demonstrated that SPC restrained MIRI induced necroptosis via regulating OGT mediated O-GlcNAcylation of RIPK3 and lessening the formulation of RIPK3/MLKL complex.	o-glcnacylation	96-111	O-linked N-acetylglucosamine (GlcNAc) transferase	Rattus norvegicus	83-86
32805318-3	2020	O-GlcNAcylation is a post translational modification (PTM) closely related to phosphorylation and its implication in the modulation of DNA-PKcs activity during the DNA Damage Response (DDR) is unknown.	o-glcnacylation	0-15	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	135-143
33231560-10	2020	Our study demonstrated that SPC restrained MIRI induced necroptosis via regulating OGT mediated O-GlcNAcylation of RIPK3 and lessening the formulation of RIPK3/MLKL complex.	o-glcnacylation	96-111	receptor-interacting serine-threonine kinase 3	Rattus norvegicus	115-120
33330510-0	2020	O-GlcNAcylation Suppresses the Ion Current IClswell by Preventing the Binding of the Protein ICln to alpha-Integrin.	o-glcnacylation	0-15	chloride nucleotide-sensitive channel 1A pseudogene 1	Homo sapiens	93-97
33330510-6	2020	Mutation of the putative YinOYang site at Ser67 rendered the ICln-induced IClswell current unresponsive to O-GlcNAc variations, and the ICln interaction with alpha-integrin insensitive to O-GlcNAcylation.	o-glcnacylation	188-203	chloride nucleotide-sensitive channel 1A pseudogene 1	Homo sapiens	61-65
33126652-7	2020	Collectively, our data support the hypothesis that O-GlcNAcylation could represent one link between nutrition and epigenetic downregulation of key tumor suppressor genes governing colon carcinogenesis including UNC5A.	o-glcnacylation	51-66	unc-5 netrin receptor A	Homo sapiens	211-216
32892442-9	2020	Moreover, OSMI-1 further promoted HBV replication by inducing autophagosome formation via inhibiting the O-GlcNAcylation of Akt and mTOR.	o-glcnacylation	105-120	AKT serine/threonine kinase 1	Homo sapiens	124-127
33251387-18	2020	O-GlcNAcylation was suppressed by miR-7-5p.	o-glcnacylation	0-15	microRNA 7-3	Homo sapiens	34-42
33153373-5	2021	Blocking the endoplasmic reticulum - Golgi trafficking with Brefeldin A or slc35B4 siRNA reduced O-GlcNAcylation, and resulted in the secretion of mitochondria with decreased membrane potential and mtDNA.	o-glcnacylation	97-112	solute carrier family 35 member B4	Homo sapiens	75-82
32970432-0	2020	Mechanistic Insights into the Hydrolysis of O-GlcNAcylation Catalyzed by Human O-GlcNAcase.	o-glcnacylation	44-59	O-GlcNAcase	Homo sapiens	79-90
33019562-4	2020	We validated this technology by imaging the O-GlcNAcylation status of beta-catenin in HeLa cells.	o-glcnacylation	44-59	catenin beta 1	Homo sapiens	70-82
32910282-6	2020	Ablation of the OGT-gene in adult cardiomyocytes (OGTKO) reduced OGT expression and O-GlcNAcylation by > 90%.	o-glcnacylation	84-99	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	16-19
32830957-5	2020	Using this method, we then report the evidence that hypoxia-inducible factor HIF1alpha is a potential target for O-GlcNAcylation, suggesting a possibly direct connection between the metabolic O-GlcNAc pathway and the hypoxia pathway.	o-glcnacylation	113-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-86
32910282-6	2020	Ablation of the OGT-gene in adult cardiomyocytes (OGTKO) reduced OGT expression and O-GlcNAcylation by > 90%.	o-glcnacylation	84-99	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	50-53
32850000-5	2020	We also identified that OGT might regulate the initiation of autophagy in cardiomyocytes through promoting the activity of ULK1 by O-GlcNAcylation.	o-glcnacylation	131-146	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	24-27
32767654-6	2020	We found that O-GlcNAcylation of LRP6 was reduced, and the overall amount of LRP6 was decreased via endocytosis-mediated lysosomal degradation during nutrient starvation.	o-glcnacylation	14-29	LDL receptor related protein 6	Homo sapiens	33-37
32850000-5	2020	We also identified that OGT might regulate the initiation of autophagy in cardiomyocytes through promoting the activity of ULK1 by O-GlcNAcylation.	o-glcnacylation	131-146	unc-51 like kinase 1	Mus musculus	123-127
32513743-0	2020	O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity.	o-glcnacylation	0-15	large tumor suppressor kinase 2	Homo sapiens	19-24
32691273-13	2020	Moreover, reduced O-GlcNAcylation of the total proteins by the shRNA-mediated silencing of the OGT gene, which is the only gene to modify proteins with the O-GlcNAc molecule, reversed the insulin resistance and endoplasmic reticulum stress phenotype, even with the externally stimulated O-GlcNAc modification conditions.	o-glcnacylation	18-33	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	95-98
32295844-0	2020	O-GlcNAcylation of myosin phosphatase targeting subunit 1 (MYPT1) dictates timely disjunction of centrosomes.	o-glcnacylation	0-15	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	19-57
32517247-5	2020	A finely tuned balance between emerin phosphorylation and O-GlcNAcylation seems to govern this dynamic and modulates emerin-BAF interaction and BAF nucleoplasmic localization during the oxidative stress response.	o-glcnacylation	58-73	emerin	Homo sapiens	117-123
32517247-5	2020	A finely tuned balance between emerin phosphorylation and O-GlcNAcylation seems to govern this dynamic and modulates emerin-BAF interaction and BAF nucleoplasmic localization during the oxidative stress response.	o-glcnacylation	58-73	BAF nuclear assembly factor 1	Homo sapiens	124-127
32517247-5	2020	A finely tuned balance between emerin phosphorylation and O-GlcNAcylation seems to govern this dynamic and modulates emerin-BAF interaction and BAF nucleoplasmic localization during the oxidative stress response.	o-glcnacylation	58-73	BAF nuclear assembly factor 1	Homo sapiens	144-147
32295844-0	2020	O-GlcNAcylation of myosin phosphatase targeting subunit 1 (MYPT1) dictates timely disjunction of centrosomes.	o-glcnacylation	0-15	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	59-64
32402277-5	2020	We discover a feedback mechanism involving key downstream effectors of DDR, ATM, ATR, and CHK1/2 that regulates OGT stability to promote O-GlcNAcylation and elevate DDR.	o-glcnacylation	137-152	ataxia telangiectasia mutated	Mus musculus	76-79
32402277-5	2020	We discover a feedback mechanism involving key downstream effectors of DDR, ATM, ATR, and CHK1/2 that regulates OGT stability to promote O-GlcNAcylation and elevate DDR.	o-glcnacylation	137-152	ataxia telangiectasia and Rad3 related	Mus musculus	81-84
32402277-5	2020	We discover a feedback mechanism involving key downstream effectors of DDR, ATM, ATR, and CHK1/2 that regulates OGT stability to promote O-GlcNAcylation and elevate DDR.	o-glcnacylation	137-152	checkpoint kinase 1	Mus musculus	90-96
32402277-5	2020	We discover a feedback mechanism involving key downstream effectors of DDR, ATM, ATR, and CHK1/2 that regulates OGT stability to promote O-GlcNAcylation and elevate DDR.	o-glcnacylation	137-152	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	112-115
32357142-11	2020	In turn, O-GlcNAcylation promotes HCC growth partially by increasing ACSL4 expression.	o-glcnacylation	9-24	acyl-CoA synthetase long chain family member 4	Homo sapiens	69-74
32369743-0	2020	O-GlcNAcylation Dampens Dpp/BMP Signaling to Ensure Proper Drosophila Embryonic Development.	o-glcnacylation	0-15	decapentaplegic	Drosophila melanogaster	24-27
32369743-0	2020	O-GlcNAcylation Dampens Dpp/BMP Signaling to Ensure Proper Drosophila Embryonic Development.	o-glcnacylation	0-15	decapentaplegic	Drosophila melanogaster	28-31
31346222-3	2019	In this study, we tested the hypothesis that increased ER stress via O-GlcNAcylation of VE-Cadherin likely contribute to endothelial permeability.	o-glcnacylation	69-84	cadherin 5	Mus musculus	88-99
32193337-5	2020	AHCY is posttranslationally modified with an O-linked beta-N-acetylglucosamine sugar (O-GlcNAcylation), which is rapidly removed upon differentiation.	o-glcnacylation	86-101	S-adenosylhomocysteine hydrolase	Mus musculus	0-4
32149084-10	2020	Our data showed that GFAT1 can regulate beta-catenin expression via modulation of the O-GlcNAcylation process.	o-glcnacylation	86-101	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	21-26
32149084-10	2020	Our data showed that GFAT1 can regulate beta-catenin expression via modulation of the O-GlcNAcylation process.	o-glcnacylation	86-101	catenin beta 1	Homo sapiens	40-52
32538734-0	2020	Elevated O-GlcNAcylation Promotes Malignant Phenotypes of Hypopharyngeal Squamous Cell Carcinoma by Stabilizing Nrf2 through Regulation of the PI3K/Akt Pathway.	o-glcnacylation	9-24	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
32538734-0	2020	Elevated O-GlcNAcylation Promotes Malignant Phenotypes of Hypopharyngeal Squamous Cell Carcinoma by Stabilizing Nrf2 through Regulation of the PI3K/Akt Pathway.	o-glcnacylation	9-24	AKT serine/threonine kinase 1	Homo sapiens	148-151
31779679-0	2019	Glucose regulates tissue-specific chondro-osteogenic differentiation of human cartilage endplate stem cells via O-GlcNAcylation of Sox9 and Runx2.	o-glcnacylation	112-127	SRY-box transcription factor 9	Homo sapiens	131-135
31779679-11	2019	The effects of O-GlcNAcylation on the downstream genes of Sox9 and Runx2 were determined by Q-PCR and western blot.	o-glcnacylation	15-30	SRY-box transcription factor 9	Homo sapiens	58-62
31779679-11	2019	The effects of O-GlcNAcylation on the downstream genes of Sox9 and Runx2 were determined by Q-PCR and western blot.	o-glcnacylation	15-30	RUNX family transcription factor 2	Homo sapiens	67-72
31779679-16	2019	Finally, O-GlcNAcylation of Sox9 and Runx2 decreased chondrogenesis and increased osteogenesis in CESCs.	o-glcnacylation	9-24	SRY-box transcription factor 9	Homo sapiens	28-32
31279900-0	2019	O-GlcNAcylation-dependent upregulation of HO1 triggers ammonia-induced oxidative stress and senescence in hepatic encephalopathy.	o-glcnacylation	0-15	heme oxygenase 1	Homo sapiens	42-45
31418572-9	2019	As we predicted, O-GlcNAcylation can improve the stability of both GLP-1 and PTH in serum despite the fact that the O-GlcNAc can be quite remote from characterized sites of peptide cleavage.	o-glcnacylation	17-32	glucagon	Homo sapiens	67-72
31418572-9	2019	As we predicted, O-GlcNAcylation can improve the stability of both GLP-1 and PTH in serum despite the fact that the O-GlcNAc can be quite remote from characterized sites of peptide cleavage.	o-glcnacylation	17-32	parathyroid hormone	Homo sapiens	77-80
31373491-3	2019	A single essential enzyme, O-GlcNAc transferase (OGT), is responsible for all nucleocytoplasmic O-GlcNAcylation.	o-glcnacylation	96-111	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	27-47
31373491-3	2019	A single essential enzyme, O-GlcNAc transferase (OGT), is responsible for all nucleocytoplasmic O-GlcNAcylation.	o-glcnacylation	96-111	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	49-52
31409917-0	2019	Augmented O-GlcNAcylation attenuates intermittent hypoxia-induced cardiac remodeling through the suppression of NFAT and NF-kappaB activities in mice.	o-glcnacylation	10-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-130
31827688-6	2019	Additionally, decreasing O-GlcNAcylation by treatment with alloxan, OGT siRNA, and OGA overexpression significantly decreased the level of autophagy substrate SQSTM1/p62, indicating that autophagic degradation was activated.	o-glcnacylation	25-40	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	68-71
31827688-6	2019	Additionally, decreasing O-GlcNAcylation by treatment with alloxan, OGT siRNA, and OGA overexpression significantly decreased the level of autophagy substrate SQSTM1/p62, indicating that autophagic degradation was activated.	o-glcnacylation	25-40	O-GlcNAcase	Mus musculus	83-86
31827688-6	2019	Additionally, decreasing O-GlcNAcylation by treatment with alloxan, OGT siRNA, and OGA overexpression significantly decreased the level of autophagy substrate SQSTM1/p62, indicating that autophagic degradation was activated.	o-glcnacylation	25-40	sequestosome 1	Mus musculus	159-165
31827688-6	2019	Additionally, decreasing O-GlcNAcylation by treatment with alloxan, OGT siRNA, and OGA overexpression significantly decreased the level of autophagy substrate SQSTM1/p62, indicating that autophagic degradation was activated.	o-glcnacylation	25-40	sequestosome 1	Mus musculus	166-169
31373757-6	2019	Combining different approaches on three human colon cell lines (HT29, HCT116 and CCD841CoN), it is herein reported that silencing O-GlcNAc transferase (OGT, the sole enzyme driving O-GlcNAcylation), only slightly affects overall N- and O-glycosylation patterns.	o-glcnacylation	181-196	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	130-150
31373757-6	2019	Combining different approaches on three human colon cell lines (HT29, HCT116 and CCD841CoN), it is herein reported that silencing O-GlcNAc transferase (OGT, the sole enzyme driving O-GlcNAcylation), only slightly affects overall N- and O-glycosylation patterns.	o-glcnacylation	181-196	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	152-155
30905621-8	2019	To verify whether O-GlcNAcylation disrupted STRA6-retinol signals, treatment of TMG and OSMI-1, transfection of OGA and OGT, and OGT siRNA were performed in HK-2 cells.	o-glcnacylation	18-33	stimulated by retinoic acid gene 6	Mus musculus	44-49
30031227-7	2018	Our data demonstrate the alteration of OGT and OGA activation coupled with the decrease of total O-GlcNAcylation levels.	o-glcnacylation	97-112	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	39-42
30905621-14	2019	CONCLUSIONS: O-GlcNAcylation significantly modified STRA6 and RALDH1, suppressed RBP4 binding activity, and disrupted retinol signals in the kidney of diabetes.	o-glcnacylation	13-28	stimulated by retinoic acid gene 6	Mus musculus	52-57
30905621-14	2019	CONCLUSIONS: O-GlcNAcylation significantly modified STRA6 and RALDH1, suppressed RBP4 binding activity, and disrupted retinol signals in the kidney of diabetes.	o-glcnacylation	13-28	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	62-68
30905621-14	2019	CONCLUSIONS: O-GlcNAcylation significantly modified STRA6 and RALDH1, suppressed RBP4 binding activity, and disrupted retinol signals in the kidney of diabetes.	o-glcnacylation	13-28	retinol binding protein 4, plasma	Mus musculus	81-85
30459708-4	2018	A fundamental post-translational modification, named O-GlcNAcylation, depends, inter alia, on these nutrients; it consists to the transfer or the removal of a unique monosaccharide (N-acetyl-D-glucosamine) to a serine or threonine hydroxyl group of nucleocytoplasmic and mitochondrial proteins in a dynamic process by the O-GlcNAc Transferase (OGT) and the O-GlcNAcase (OGA), respectively.	o-glcnacylation	53-68	O-GlcNAcase	Homo sapiens	357-368
30459708-4	2018	A fundamental post-translational modification, named O-GlcNAcylation, depends, inter alia, on these nutrients; it consists to the transfer or the removal of a unique monosaccharide (N-acetyl-D-glucosamine) to a serine or threonine hydroxyl group of nucleocytoplasmic and mitochondrial proteins in a dynamic process by the O-GlcNAc Transferase (OGT) and the O-GlcNAcase (OGA), respectively.	o-glcnacylation	53-68	O-GlcNAcase	Homo sapiens	370-373
30733333-0	2019	O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina.	o-glcnacylation	0-15	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	75-81
30651314-9	2019	We also demonstrate that O-GlcNAcylation can inhibit the aggregation of an aggressive mutant of alpha-synuclein, indicating that therapies currently in development that increase this modification might be applied in animal models that rely on this mutant.	o-glcnacylation	25-40	synuclein alpha	Homo sapiens	96-111
30459708-4	2018	A fundamental post-translational modification, named O-GlcNAcylation, depends, inter alia, on these nutrients; it consists to the transfer or the removal of a unique monosaccharide (N-acetyl-D-glucosamine) to a serine or threonine hydroxyl group of nucleocytoplasmic and mitochondrial proteins in a dynamic process by the O-GlcNAc Transferase (OGT) and the O-GlcNAcase (OGA), respectively.	o-glcnacylation	53-68	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	322-342
30459708-4	2018	A fundamental post-translational modification, named O-GlcNAcylation, depends, inter alia, on these nutrients; it consists to the transfer or the removal of a unique monosaccharide (N-acetyl-D-glucosamine) to a serine or threonine hydroxyl group of nucleocytoplasmic and mitochondrial proteins in a dynamic process by the O-GlcNAc Transferase (OGT) and the O-GlcNAcase (OGA), respectively.	o-glcnacylation	53-68	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	344-347
30031227-9	2018	In parallel, we analysed the O-GlcNAcylation/phosphorylation ratio of IRS1 and AKT, whose alterations may contribute to insulin resistance and reduced glucose uptake.	o-glcnacylation	29-44	insulin receptor substrate 1	Mus musculus	70-74
29391154-1	2018	O-GlcNAcylation, the addition of beta-N-acetylglucosamine (O-GlcNAc) moiety to Ser/Thr residues, is a sensor of the cell metabolic state.	o-glcnacylation	0-15	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	33-67
28624365-3	2017	O-GlcNAcylation is a novel type of O-glycosylation, mediated by O-GlcNAc transferase attaching O-beta-N-acetylglucosamine (O-GlcNAc) to serine/threonine residues of the target proteins.	o-glcnacylation	0-15	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	64-131
30123425-3	2018	O-GlcNAcylation, the attachment of beta-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of intracellular proteins, modulates protein functions and is implicated in cancer pathogenesis.	o-glcnacylation	0-15	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	35-69
30002415-9	2018	An increased O-GlcNAcylation of FoxO1 was revealed upon NDPK-B depletion.	o-glcnacylation	13-28	forkhead box O1	Mus musculus	32-37
30002415-9	2018	An increased O-GlcNAcylation of FoxO1 was revealed upon NDPK-B depletion.	o-glcnacylation	13-28	NME/NM23 nucleoside diphosphate kinase 2	Mus musculus	56-62
28742148-4	2017	O-GlcNAcylation consists in the addition of O-linked-N-acetylglucosamine (O-GlcNAc) on Serine or Threonine residues, a process controlled by two enzymes: O-GlcNAc transferase (OGT), which transfers O-GlcNAc on proteins, and O-GlcNAcase (OGA), which removes it.	o-glcnacylation	0-15	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	154-174
28742148-4	2017	O-GlcNAcylation consists in the addition of O-linked-N-acetylglucosamine (O-GlcNAc) on Serine or Threonine residues, a process controlled by two enzymes: O-GlcNAc transferase (OGT), which transfers O-GlcNAc on proteins, and O-GlcNAcase (OGA), which removes it.	o-glcnacylation	0-15	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	176-179
28742148-4	2017	O-GlcNAcylation consists in the addition of O-linked-N-acetylglucosamine (O-GlcNAc) on Serine or Threonine residues, a process controlled by two enzymes: O-GlcNAc transferase (OGT), which transfers O-GlcNAc on proteins, and O-GlcNAcase (OGA), which removes it.	o-glcnacylation	0-15	O-GlcNAcase	Homo sapiens	224-235
28742148-4	2017	O-GlcNAcylation consists in the addition of O-linked-N-acetylglucosamine (O-GlcNAc) on Serine or Threonine residues, a process controlled by two enzymes: O-GlcNAc transferase (OGT), which transfers O-GlcNAc on proteins, and O-GlcNAcase (OGA), which removes it.	o-glcnacylation	0-15	O-GlcNAcase	Homo sapiens	237-240