PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21601234-3	2011	The objective of the present study was to explore the structural and conformational requirements of PBDE compounds as human estrogen receptor alpha (hERalpha) agonists, and further screened out hERalpha agonists from PBDE compounds.	pentabromodiphenyl ether	100-104	estrogen receptor 1	Homo sapiens	124-147
21601234-3	2011	The objective of the present study was to explore the structural and conformational requirements of PBDE compounds as human estrogen receptor alpha (hERalpha) agonists, and further screened out hERalpha agonists from PBDE compounds.	pentabromodiphenyl ether	100-104	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	149-157
19069643-8	2008	XRCC1 mRNA expression in cells treated by 100 micromol/L NAC + 10 micromol/L PBDE-47 + 5 micromol/L PCB153 group was significantly higher than that in 10 micromol/L PBDE-47 + 5 micromol/L PCB153 group (P < 0.05).	pentabromodiphenyl ether	77-81	X-ray repair cross complementing 1	Homo sapiens	0-5
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	124-128	X-ray repair cross complementing 1	Homo sapiens	30-69
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	124-128	X-ray repair cross complementing 1	Homo sapiens	71-76
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	124-128	X-ray repair cross complementing 3	Homo sapiens	207-246
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	124-128	X-ray repair cross complementing 3	Homo sapiens	248-253
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 1	Homo sapiens	30-69
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 1	Homo sapiens	71-76
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 3	Homo sapiens	207-246
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 3	Homo sapiens	248-253
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 1	Homo sapiens	30-69
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 1	Homo sapiens	71-76
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 3	Homo sapiens	207-246
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 3	Homo sapiens	248-253
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 1	Homo sapiens	30-69
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 1	Homo sapiens	71-76
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 3	Homo sapiens	207-246
18948301-6	2009	The mRNA expression levels of X-ray repair cross-complementing gene 1 (Xrcc1) were significantly decreased in the 10 microM PBDE-47, 5 microM PBDE-47 + PCB153, and 10 microM PBDE-47 + PCB153 groups, whereas X-ray repair cross-complementing gene 3 (Xrcc3) were significantly increased in the 10 microM PBDE-47 and 10 microM PBDE-47 + PCB153 groups compared with the control (p < 0.05).	pentabromodiphenyl ether	142-146	X-ray repair cross complementing 3	Homo sapiens	248-253
20488850-9	2011	PentaBDE caused an increase in relative liver mass, cytochromes P-450 (after two highest doses), a dose-dependent increase in the activity of CYP lA (12-26 fold) and CYP 2B (5-6 fold) as well as the levels of CYP lAl (16-50 fold) and CYP 4A (2-3 fold) in liver.	pentabromodiphenyl ether	0-8	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	142-145
20488850-9	2011	PentaBDE caused an increase in relative liver mass, cytochromes P-450 (after two highest doses), a dose-dependent increase in the activity of CYP lA (12-26 fold) and CYP 2B (5-6 fold) as well as the levels of CYP lAl (16-50 fold) and CYP 4A (2-3 fold) in liver.	pentabromodiphenyl ether	0-8	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	166-169
20488850-9	2011	PentaBDE caused an increase in relative liver mass, cytochromes P-450 (after two highest doses), a dose-dependent increase in the activity of CYP lA (12-26 fold) and CYP 2B (5-6 fold) as well as the levels of CYP lAl (16-50 fold) and CYP 4A (2-3 fold) in liver.	pentabromodiphenyl ether	0-8	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	166-169
20488850-9	2011	PentaBDE caused an increase in relative liver mass, cytochromes P-450 (after two highest doses), a dose-dependent increase in the activity of CYP lA (12-26 fold) and CYP 2B (5-6 fold) as well as the levels of CYP lAl (16-50 fold) and CYP 4A (2-3 fold) in liver.	pentabromodiphenyl ether	0-8	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	166-169
19631710-0	2009	Technical pentabromodiphenyl ether and hexabromocyclododecane as activators of the pregnane-X-receptor (PXR).	pentabromodiphenyl ether	10-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	83-102
19631710-0	2009	Technical pentabromodiphenyl ether and hexabromocyclododecane as activators of the pregnane-X-receptor (PXR).	pentabromodiphenyl ether	10-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	104-107
19631710-4	2009	PentaBDE mix and HBCD have recently been found to induce cytochrome P450 (CYP) 3 enzymes in rat liver.	pentabromodiphenyl ether	0-8	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	57-80
19631710-5	2009	In this study we tested both technical pentaBDE mix and HBCD for their potency to induce CYP3A enzymes in rat hepatocytes in primary culture, and in rat H4IIE and human HepG2 hepatoma cells.	pentabromodiphenyl ether	39-47	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	89-94
19746742-5	2009	In addition, bsCAR was weakly deactivated by PBDE99, whereas mCAR transcriptional activity decreased weakly by PBDE100, PBDE154, and PBDE187.	pentabromodiphenyl ether	111-118	coxsackie virus and adenovirus receptor	Mus musculus	61-65
19360447-10	2009	DISCUSSION: BDE-209 is a source of PBDEs primarily present in OctaBDEs but also to some extent in PentaBDEs, both being commercial products now banned within the EU and in several states within the USA.	pentabromodiphenyl ether	98-107	homeobox D13	Homo sapiens	12-15
19069643-8	2008	XRCC1 mRNA expression in cells treated by 100 micromol/L NAC + 10 micromol/L PBDE-47 + 5 micromol/L PCB153 group was significantly higher than that in 10 micromol/L PBDE-47 + 5 micromol/L PCB153 group (P < 0.05).	pentabromodiphenyl ether	77-81	X-linked Kx blood group	Homo sapiens	57-60
19069643-8	2008	XRCC1 mRNA expression in cells treated by 100 micromol/L NAC + 10 micromol/L PBDE-47 + 5 micromol/L PCB153 group was significantly higher than that in 10 micromol/L PBDE-47 + 5 micromol/L PCB153 group (P < 0.05).	pentabromodiphenyl ether	165-169	X-ray repair cross complementing 1	Homo sapiens	0-5
19069643-8	2008	XRCC1 mRNA expression in cells treated by 100 micromol/L NAC + 10 micromol/L PBDE-47 + 5 micromol/L PCB153 group was significantly higher than that in 10 micromol/L PBDE-47 + 5 micromol/L PCB153 group (P < 0.05).	pentabromodiphenyl ether	165-169	X-linked Kx blood group	Homo sapiens	57-60
18453545-0	2008	DE-71-induced apoptosis involving intracellular calcium and the Bax-mitochondria-caspase protease pathway in human neuroblastoma cells in vitro.	pentabromodiphenyl ether	0-5	BCL2 associated X, apoptosis regulator	Homo sapiens	64-67
18049786-5	2008	BDE-209 was the predominant congener, accounting for 79% of the total PBDE concentration in the Shiawassee River and 90% in the Saginaw River.	pentabromodiphenyl ether	70-74	homeobox D13	Homo sapiens	0-3
12408642-1	2002	The short-term effects of the commercial PBDE flame retardant mixtures Penta-BDE and cta-BDE on the expression of cytochrome P450 1A (CYP1A), vitellogenin (Vtg) and zona radiata proteins (Zrp) were investigated in juvenile salmon (Salmo salar).	pentabromodiphenyl ether	41-45	cytochrome P450, family 1, subfamily A	Salmo salar	114-132
17416222-10	2007	Derivative chromatography was finally used to study the peak purity of 2,2",3,4,4"-pentabromodiphenyl ether (BDE 85) in technical pentabromo diphenyl ether (DE-71).	pentabromodiphenyl ether	71-107	homeobox D13	Homo sapiens	109-112
17416222-10	2007	Derivative chromatography was finally used to study the peak purity of 2,2",3,4,4"-pentabromodiphenyl ether (BDE 85) in technical pentabromo diphenyl ether (DE-71).	pentabromodiphenyl ether	130-155	homeobox D13	Homo sapiens	109-112
12408642-1	2002	The short-term effects of the commercial PBDE flame retardant mixtures Penta-BDE and cta-BDE on the expression of cytochrome P450 1A (CYP1A), vitellogenin (Vtg) and zona radiata proteins (Zrp) were investigated in juvenile salmon (Salmo salar).	pentabromodiphenyl ether	41-45	vitellogenin	Salmo salar	142-154
12408642-1	2002	The short-term effects of the commercial PBDE flame retardant mixtures Penta-BDE and cta-BDE on the expression of cytochrome P450 1A (CYP1A), vitellogenin (Vtg) and zona radiata proteins (Zrp) were investigated in juvenile salmon (Salmo salar).	pentabromodiphenyl ether	71-80	cytochrome P450, family 1, subfamily A	Salmo salar	114-132
12408642-1	2002	The short-term effects of the commercial PBDE flame retardant mixtures Penta-BDE and cta-BDE on the expression of cytochrome P450 1A (CYP1A), vitellogenin (Vtg) and zona radiata proteins (Zrp) were investigated in juvenile salmon (Salmo salar).	pentabromodiphenyl ether	71-80	cytochrome P450, family 1, subfamily A	Salmo salar	134-139
12408642-1	2002	The short-term effects of the commercial PBDE flame retardant mixtures Penta-BDE and cta-BDE on the expression of cytochrome P450 1A (CYP1A), vitellogenin (Vtg) and zona radiata proteins (Zrp) were investigated in juvenile salmon (Salmo salar).	pentabromodiphenyl ether	71-80	vitellogenin	Salmo salar	142-154
12408642-1	2002	The short-term effects of the commercial PBDE flame retardant mixtures Penta-BDE and cta-BDE on the expression of cytochrome P450 1A (CYP1A), vitellogenin (Vtg) and zona radiata proteins (Zrp) were investigated in juvenile salmon (Salmo salar).	pentabromodiphenyl ether	71-80	vitellogenin	Salmo salar	156-159
10580757-8	1999	BDE-47 was the most abundant PBDE congener in all samples.	pentabromodiphenyl ether	29-33	homeobox D13	Homo sapiens	0-3
34273373-4	2021	Furthermore PBDEs (47, 99) (100 nM) increased Muc5AC and Muc5B mRNA, and PBDE 47 (100 nM) IL-8 mRNA via EZH2 in pNHBEs.	pentabromodiphenyl ether	73-77	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	104-108
32213394-4	2020	For AhR binding, the offset or edge-on pi-pi stackings with aromatic motifs including Phe289, Phe345 and His285 were shown to be structurally required whereas the electrostatic attraction validated for AhR binding to dioxins might be less effective for 2,2",3,4,4"-pentabromodiphenyl ether (BDE-85).	pentabromodiphenyl ether	253-289	aryl hydrocarbon receptor	Homo sapiens	4-7
34273373-7	2021	SIGNIFICANCE: PBDE inhalation might promote inflammation/cancer via EZH2 methyltransferase activity and H3K27me3, k-RAS and ERk1/2 involvement, generating adverse health outcomes of the human lung.	pentabromodiphenyl ether	14-18	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	68-72
34273373-7	2021	SIGNIFICANCE: PBDE inhalation might promote inflammation/cancer via EZH2 methyltransferase activity and H3K27me3, k-RAS and ERk1/2 involvement, generating adverse health outcomes of the human lung.	pentabromodiphenyl ether	14-18	KRAS proto-oncogene, GTPase	Homo sapiens	114-119
34273373-7	2021	SIGNIFICANCE: PBDE inhalation might promote inflammation/cancer via EZH2 methyltransferase activity and H3K27me3, k-RAS and ERk1/2 involvement, generating adverse health outcomes of the human lung.	pentabromodiphenyl ether	14-18	mitogen-activated protein kinase 3	Homo sapiens	124-130
35575305-4	2022	First, our results indicated that PBDE 47 affected the PPARgamma pathway most efficiently in THP-1 macrophages by transcriptomic analysis.	pentabromodiphenyl ether	34-38	peroxisome proliferator activated receptor gamma	Homo sapiens	55-64
35575305-5	2022	Second, the PPARgamma target genes CD36 and FABP4, responsible for lipid uptake and accumulation in macrophages, were consistently upregulated both at transcriptional and translational levels in THP-1 macrophages upon PBDE 47.	pentabromodiphenyl ether	218-222	peroxisome proliferator activated receptor gamma	Homo sapiens	12-21
35575305-7	2022	Thus, coincident with the selective upregulation of the PPARgamma target genes CD36 and FABP4, PBDE 47, distinct from rosiglitazone, functionally resulted in more lipid accumulation and oxLDL uptake in THP-1 macrophages through high-content analysis (HCA).	pentabromodiphenyl ether	95-99	peroxisome proliferator activated receptor gamma	Homo sapiens	56-65
35575305-10	2022	PBDE 47 was revealed to interact with helix 3 and helix 5 but not helix 12 in the PPARgamma-LBD.	pentabromodiphenyl ether	0-4	peroxisome proliferator activated receptor gamma	Homo sapiens	82-91
35575305-11	2022	Collectively, these results unraveled the potential cardiovascular toxicity of PBDE 47 by selective activation of PPARgamma to facilitate foam cell formation for the first time.	pentabromodiphenyl ether	79-83	peroxisome proliferator activated receptor gamma	Homo sapiens	114-123
33124384-14	2020	During the degradation process from Octa-BDE to Penta-BDE, some Octa-BDE and Hexa-BDE homologues accumulated due to relatively slower degradation velocities, and the degradation rates of Penta-BDE to Tri-BDE were above 70%.	pentabromodiphenyl ether	48-57	hexosaminidase subunit alpha	Homo sapiens	77-81
33124384-14	2020	During the degradation process from Octa-BDE to Penta-BDE, some Octa-BDE and Hexa-BDE homologues accumulated due to relatively slower degradation velocities, and the degradation rates of Penta-BDE to Tri-BDE were above 70%.	pentabromodiphenyl ether	187-196	hexosaminidase subunit alpha	Homo sapiens	77-81
32517082-11	2020	It was also observed that some interacting residues in hP-gp are the same when compared to those observed in a co-crystallized ligand (PBDE-100) with mouse P-gp (PDB ID: 4XWK).	pentabromodiphenyl ether	135-143	phosphoglycolate phosphatase	Homo sapiens	55-60
32517082-11	2020	It was also observed that some interacting residues in hP-gp are the same when compared to those observed in a co-crystallized ligand (PBDE-100) with mouse P-gp (PDB ID: 4XWK).	pentabromodiphenyl ether	135-143	phosphoglycolate phosphatase	Mus musculus	56-60
29096325-3	2017	Results showed PBDE-47 could increase autophagic level (performation of cell ultrastructure with double membrane formation, MDC-positive cells raised, autophagy-related proteins LC3-II, Beclin1 and P62 increased) after cells exposed to PBDE-47.	pentabromodiphenyl ether	15-19	beclin 1	Homo sapiens	186-193
32000026-2	2020	In this study, the compound-specific stable isotope analysis (CSIA) was applied to characterize microbial degradation of BDE-153, one of the prevailing and toxic PBDE congeners, in natural wetland soils.	pentabromodiphenyl ether	162-166	homeobox D13	Homo sapiens	121-124
29801251-7	2018	Regarding ecological risk estimation, high molecular PBDEs pose a high risk quotient (RQ > 1) to sediment dwelling organism along the 33 sampling stations, suggesting that penta-BDEs and deca-BDE are the major ecological risk drivers in the Danshui River basin.	pentabromodiphenyl ether	175-185	homeobox D13	Homo sapiens	54-57
31886849-11	2020	Higher exposure to the PBDE mixture was associated with reduced abdominal circumference (-2.4 mm; 95% CI, -4.0 to -0.5 mm) and femur length (-0.5 mm; 95% CI, -1.0 to -0.1 mm), and the dioxin-like PCB mixture was associated with reduced head circumference (-6.4 mm; 95% CI, -8.4 to -4.3 mm) and abdominal circumference (-2.4 mm; 95% CI, -3.9 to -0.8 mm).	pentabromodiphenyl ether	23-27	pyruvate carboxylase	Homo sapiens	196-199
30206662-8	2018	Decreases in other transport transcripts (ABCG5 & 8) provided a plausible mechanism for lipid accumulation, characterized by a treatment-related liver fatty change after PBDE-47 and PBDE mixture exposure.	pentabromodiphenyl ether	170-174	ATP binding cassette subfamily G member 5	Rattus norvegicus	42-47
30206662-8	2018	Decreases in other transport transcripts (ABCG5 & 8) provided a plausible mechanism for lipid accumulation, characterized by a treatment-related liver fatty change after PBDE-47 and PBDE mixture exposure.	pentabromodiphenyl ether	182-186	ATP binding cassette subfamily G member 5	Rattus norvegicus	42-47
30533462-2	2018	PBDE-induced hepatocellular tumors harbored Hras and Ctnnb1 mutations and the methods for these studies are provided.	pentabromodiphenyl ether	0-4	catenin beta 1	Rattus norvegicus	53-59
29096325-3	2017	Results showed PBDE-47 could increase autophagic level (performation of cell ultrastructure with double membrane formation, MDC-positive cells raised, autophagy-related proteins LC3-II, Beclin1 and P62 increased) after cells exposed to PBDE-47.	pentabromodiphenyl ether	15-19	nucleoporin 62	Homo sapiens	198-201
29657921-2	2017	Our previous study confirmed that 2,2",4,4",5-pentabromodiphenyl ether (BDE-99) induced cytochrome P450 1A (Cyp1a) via aryl hydrocarbon receptor (Ahr)-mediated signaling in the zebrafish liver cell line (ZFL) in vitro.	pentabromodiphenyl ether	34-70	cytochrome P450, family 1, subfamily A	Danio rerio	108-113
29657921-2	2017	Our previous study confirmed that 2,2",4,4",5-pentabromodiphenyl ether (BDE-99) induced cytochrome P450 1A (Cyp1a) via aryl hydrocarbon receptor (Ahr)-mediated signaling in the zebrafish liver cell line (ZFL) in vitro.	pentabromodiphenyl ether	34-70	aryl hydrocarbon receptor 1a	Danio rerio	119-144
29657921-2	2017	Our previous study confirmed that 2,2",4,4",5-pentabromodiphenyl ether (BDE-99) induced cytochrome P450 1A (Cyp1a) via aryl hydrocarbon receptor (Ahr)-mediated signaling in the zebrafish liver cell line (ZFL) in vitro.	pentabromodiphenyl ether	34-70	aryl hydrocarbon receptor 1a	Danio rerio	146-149
29096325-4	2017	Then cells were exposed to PBDE-47 (1, 5, 10mumol/L) respectively for 1, 3, 6, 9, 12, 18, 24h, and the results showed that PBDE-47 increased the levels of LC3-II, Beclin1 and P62 in 5, 10mumol/L (9, 12, 18, 24h) PBDE-47 exposed groups.	pentabromodiphenyl ether	123-127	beclin 1	Homo sapiens	163-170
29096325-4	2017	Then cells were exposed to PBDE-47 (1, 5, 10mumol/L) respectively for 1, 3, 6, 9, 12, 18, 24h, and the results showed that PBDE-47 increased the levels of LC3-II, Beclin1 and P62 in 5, 10mumol/L (9, 12, 18, 24h) PBDE-47 exposed groups.	pentabromodiphenyl ether	123-127	nucleoporin 62	Homo sapiens	175-178
29096325-4	2017	Then cells were exposed to PBDE-47 (1, 5, 10mumol/L) respectively for 1, 3, 6, 9, 12, 18, 24h, and the results showed that PBDE-47 increased the levels of LC3-II, Beclin1 and P62 in 5, 10mumol/L (9, 12, 18, 24h) PBDE-47 exposed groups.	pentabromodiphenyl ether	123-127	beclin 1	Homo sapiens	163-170
29096325-4	2017	Then cells were exposed to PBDE-47 (1, 5, 10mumol/L) respectively for 1, 3, 6, 9, 12, 18, 24h, and the results showed that PBDE-47 increased the levels of LC3-II, Beclin1 and P62 in 5, 10mumol/L (9, 12, 18, 24h) PBDE-47 exposed groups.	pentabromodiphenyl ether	123-127	nucleoporin 62	Homo sapiens	175-178
25565148-3	2015	This paper demonstrates the applicability of COSMO-RS in identifying unknown PBDE metabolites of 2,2",4,4"-tetrabromodiphenyl ether (BDE-47) and 2,2",4,4",6-pentabromodiphenyl ether (BDE-100).	pentabromodiphenyl ether	145-181	homeobox D13	Homo sapiens	78-81
27449334-6	2016	In the 10mg/kg bw PBDE-47 group, PARP and Caspase-3 were markedly activated, indicative of apoptosis.	pentabromodiphenyl ether	18-22	caspase 3	Rattus norvegicus	42-51
26254212-5	2015	At 2 months of age neonatally PBDE 99 treated mice had altered spontaneous behaviour, and cortical transcription of AChE, nAChR-alpha4, nAChR-beta2 and mAChR-5 were elevated.	pentabromodiphenyl ether	30-34	acetylcholinesterase	Mus musculus	116-120
25629761-0	2015	Primary role of cytochrome P450 2B6 in the oxidative metabolism of 2,2",4,4",6-pentabromodiphenyl ether (BDE-100) to hydroxylated BDEs.	pentabromodiphenyl ether	67-103	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	16-35
25629761-0	2015	Primary role of cytochrome P450 2B6 in the oxidative metabolism of 2,2",4,4",6-pentabromodiphenyl ether (BDE-100) to hydroxylated BDEs.	pentabromodiphenyl ether	67-103	homeobox D13	Homo sapiens	105-108
25629761-3	2015	This study characterizes the in vitro metabolism of 2,2",4,4",6-pentabromodiphenyl ether (BDE-100), one of the most abundant PBDE congeners found in humans, by recombinant human P450s and pooled human liver microsomes (HLMs).	pentabromodiphenyl ether	52-88	homeobox D13	Homo sapiens	90-93
25908029-0	2015	BDE-99 (2,2",4,4",5-pentabromodiphenyl ether) triggers epithelial-mesenchymal transition in colorectal cancer cells via PI3K/Akt/Snail signaling pathway.	pentabromodiphenyl ether	8-44	homeobox D13	Homo sapiens	0-3
25908029-0	2015	BDE-99 (2,2",4,4",5-pentabromodiphenyl ether) triggers epithelial-mesenchymal transition in colorectal cancer cells via PI3K/Akt/Snail signaling pathway.	pentabromodiphenyl ether	8-44	AKT serine/threonine kinase 1	Homo sapiens	125-128
25908029-0	2015	BDE-99 (2,2",4,4",5-pentabromodiphenyl ether) triggers epithelial-mesenchymal transition in colorectal cancer cells via PI3K/Akt/Snail signaling pathway.	pentabromodiphenyl ether	8-44	snail family transcriptional repressor 1	Homo sapiens	129-134
25908029-1	2015	PURPOSE: The gut is in direct contact with BDE-99 (2,2",4,4",5-pentabromodiphenyl ether), one of the most abundant PBDE congeners in the environment and in human tissues.	pentabromodiphenyl ether	51-87	homeobox D13	Homo sapiens	43-46
25908029-1	2015	PURPOSE: The gut is in direct contact with BDE-99 (2,2",4,4",5-pentabromodiphenyl ether), one of the most abundant PBDE congeners in the environment and in human tissues.	pentabromodiphenyl ether	115-119	homeobox D13	Homo sapiens	43-46
28395225-0	2017	Molecular structure and vibrational spectra of 2,2",4,4",6-pentabromodiphenyl ether (BDE 100).	pentabromodiphenyl ether	47-83	homeobox D13	Homo sapiens	85-88
28395225-1	2017	In this work, FT-IR ATR and Raman (laser line 532nm) spectra of 2,2",4,4",6-pentabromodiphenyl ether (BDE 100) have been recorded in the range of 4000-650 and 4000-100cm-1, respectively.	pentabromodiphenyl ether	64-100	homeobox D13	Homo sapiens	102-105
28363092-7	2017	Our results confirm that the use of deca-BDE commercial mixture is a major source of PBDE contamination in RD.	pentabromodiphenyl ether	85-89	homeobox D13	Homo sapiens	41-44
28189061-3	2017	Apoptosis protein Cleaved Caspase-3 and Cleaved PARP was significantly higher in PBDE dose groups and BCL-2 levels in high PBDE dose groups were significantly lower.	pentabromodiphenyl ether	123-127	BCL2, apoptosis regulator	Rattus norvegicus	102-107
26826361-4	2016	BDE 47, 99, 100 and 153 were the dominating congeners, suggesting recent and ongoing exposure to banned, commercial PentaBDE mixture.	pentabromodiphenyl ether	116-124	homeobox D13	Homo sapiens	0-3
25956475-2	2015	In humans, the hydroxylated metabolites of 2,2",4,4"-tetrabromodiphenyl ether (BDE-47) and 2,2",4,4",5-pentabromodiphenyl ether (BDE-99) formed in vitro have also been detected in vivo.	pentabromodiphenyl ether	91-127	homeobox D13	Homo sapiens	129-132
25629761-10	2015	Compared to the metabolism of 2,2",4,4"-tetrabromodiphenyl ether (BDE-47) and 2,2",4,4",5-pentabromodiphenyl ether (BDE-99) reported in previous studies, BDE-100 appears to be more slowly metabolized by P450s due to the presence of a third ortho-substituted bromine atom.	pentabromodiphenyl ether	78-114	homeobox D13	Homo sapiens	116-119
25629761-10	2015	Compared to the metabolism of 2,2",4,4"-tetrabromodiphenyl ether (BDE-47) and 2,2",4,4",5-pentabromodiphenyl ether (BDE-99) reported in previous studies, BDE-100 appears to be more slowly metabolized by P450s due to the presence of a third ortho-substituted bromine atom.	pentabromodiphenyl ether	78-114	homeobox D13	Homo sapiens	116-119
24044724-9	2013	Overall, in our study, the stable reposition of H12 is characterized as a computational mark for identifying AR antagonists from PBDE metabolites, or even other various environmental pollutants.	pentabromodiphenyl ether	129-133	androgen receptor	Homo sapiens	109-111
25511268-7	2014	The hippocampal SOD activity of PBDE-209 group [(59.29+-37.09) U/mg pro] was reduced significantly as compared with those of the control group [(93.28+-21.75) U/mg pro] and PBDE-209+NAC group [(98.92+-21.54) U/mgpro] (P < 0.05).	pentabromodiphenyl ether	32-36	NLR family, pyrin domain containing 1A	Mus musculus	182-185
25511268-9	2014	Western blot results showed that the ratios of p-p38/p38 and p-ERK/ERK in the hippocampus were significantly higher in the PBDE-209 group than in the control group and PBDE-209+NAC group (P < 0.05).	pentabromodiphenyl ether	123-127	mitogen-activated protein kinase 14	Mus musculus	49-52
25511268-9	2014	Western blot results showed that the ratios of p-p38/p38 and p-ERK/ERK in the hippocampus were significantly higher in the PBDE-209 group than in the control group and PBDE-209+NAC group (P < 0.05).	pentabromodiphenyl ether	123-127	mitogen-activated protein kinase 14	Mus musculus	53-56
25511268-9	2014	Western blot results showed that the ratios of p-p38/p38 and p-ERK/ERK in the hippocampus were significantly higher in the PBDE-209 group than in the control group and PBDE-209+NAC group (P < 0.05).	pentabromodiphenyl ether	123-127	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	61-66
25511268-9	2014	Western blot results showed that the ratios of p-p38/p38 and p-ERK/ERK in the hippocampus were significantly higher in the PBDE-209 group than in the control group and PBDE-209+NAC group (P < 0.05).	pentabromodiphenyl ether	123-127	mitogen-activated protein kinase 1	Mus musculus	63-66
25511268-9	2014	Western blot results showed that the ratios of p-p38/p38 and p-ERK/ERK in the hippocampus were significantly higher in the PBDE-209 group than in the control group and PBDE-209+NAC group (P < 0.05).	pentabromodiphenyl ether	123-127	NLR family, pyrin domain containing 1A	Mus musculus	177-180
25511268-9	2014	Western blot results showed that the ratios of p-p38/p38 and p-ERK/ERK in the hippocampus were significantly higher in the PBDE-209 group than in the control group and PBDE-209+NAC group (P < 0.05).	pentabromodiphenyl ether	168-172	mitogen-activated protein kinase 14	Mus musculus	49-52
25511268-9	2014	Western blot results showed that the ratios of p-p38/p38 and p-ERK/ERK in the hippocampus were significantly higher in the PBDE-209 group than in the control group and PBDE-209+NAC group (P < 0.05).	pentabromodiphenyl ether	168-172	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	61-66
25511268-9	2014	Western blot results showed that the ratios of p-p38/p38 and p-ERK/ERK in the hippocampus were significantly higher in the PBDE-209 group than in the control group and PBDE-209+NAC group (P < 0.05).	pentabromodiphenyl ether	168-172	mitogen-activated protein kinase 1	Mus musculus	63-66
25511268-9	2014	Western blot results showed that the ratios of p-p38/p38 and p-ERK/ERK in the hippocampus were significantly higher in the PBDE-209 group than in the control group and PBDE-209+NAC group (P < 0.05).	pentabromodiphenyl ether	168-172	NLR family, pyrin domain containing 1A	Mus musculus	177-180
25767823-0	2014	The PBDE metabolite 6-OH-BDE 47 affects melanin pigmentation and THRbeta MRNA expression in the eye of zebrafish embryos.	pentabromodiphenyl ether	4-8	thyroid hormone receptor beta	Danio rerio	65-72
22200319-4	2012	Eight PCB congeners with different degree of chlorination were selected as a training set for modeling the logk(w)-logk correlation on both silica-based C(8) and C(18) stationary phases to evaluate logk(w) of sample compounds including seven PCB, six PBB and eight PBDE congeners.	pentabromodiphenyl ether	265-269	pyruvate carboxylase	Homo sapiens	6-9
23333513-6	2013	In multivariable linear regression models adjusted by age and body mass index (BMI), significant positive associations were found between house dust concentrations of pentaBDEs and serum levels of free T4, total T3, estradiol, and sex hormone binding globulin (SHBG), along with an inverse association with follicle stimulating hormone (FSH).	pentabromodiphenyl ether	167-176	sex hormone binding globulin	Homo sapiens	231-259
23333513-6	2013	In multivariable linear regression models adjusted by age and body mass index (BMI), significant positive associations were found between house dust concentrations of pentaBDEs and serum levels of free T4, total T3, estradiol, and sex hormone binding globulin (SHBG), along with an inverse association with follicle stimulating hormone (FSH).	pentabromodiphenyl ether	167-176	sex hormone binding globulin	Homo sapiens	261-265
23146276-5	2013	Furthermore, higher enzyme concentrations of NaR and GST led to higher PBDE debromination rates, and the time-dependent activities of NaR and GST in the root crude enzyme extracts were similar to the trends of PBDE depletion.	pentabromodiphenyl ether	71-75	glutathione S-transferase	Zea mays	53-56
23146276-5	2013	Furthermore, higher enzyme concentrations of NaR and GST led to higher PBDE debromination rates, and the time-dependent activities of NaR and GST in the root crude enzyme extracts were similar to the trends of PBDE depletion.	pentabromodiphenyl ether	210-214	glutathione S-transferase	Zea mays	142-145
23190380-0	2013	SO-MUM: a coupled atmospheric transport and multimedia model used to predict intraurban-scale PCB and PBDE emissions and fate.	pentabromodiphenyl ether	102-106	latexin	Homo sapiens	3-6
22840536-6	2012	PBDE congeners and homologues analysis and principal component analysis (PCA) also revealed that the major source of PBDE in the soil samples was associated with the prevalent use of technical decabromodiphenyl ether (Deca-BDE) and pentabromodiphenyl ether (Penta-BDE).	pentabromodiphenyl ether	232-256	homeobox D13	Homo sapiens	118-121
22902999-3	2012	Food consumption contributed more to daily intake of Sigma(8)BDE, especially for lower-brominated PBDE congeners.	pentabromodiphenyl ether	98-102	homeobox D13	Homo sapiens	61-64
22454545-7	2012	Although the suppression of TNF-alpha with DE-71 was similar to that of estrogen, the inhibitory effects of DE-71 were not found to be dependent on the estrogen receptor.	pentabromodiphenyl ether	43-48	tumor necrosis factor	Homo sapiens	28-37
21767471-6	2011	CYP1A was 7.41- and 7.37-fold up-regulated in hepatocytes exposed to BDE47 and PBDE-MIX, respectively, and was the only biotransformation pathway affected by the PBDE exposure.	pentabromodiphenyl ether	79-83	cytochrome P450, family 1, subfamily A	Salmo salar	0-5
21715243-7	2011	PBDE office dust concentrations were weakly correlated with measurements in handwipes: r = 0.35 (p = 0.06) for pentaBDE (sum of BDE congeners 28/33, 47, 99, 100, and 153) and 0.33 (p = 0.07) for BDE-209.	pentabromodiphenyl ether	111-119	homeobox D13	Homo sapiens	1-4