PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33857595-13	2021	Furthermore, isoorientin, orientin, isovitexin, and vitexin produced significant concentration-dependent inhibition with IC50 values (muM) of COX-2: 7.13, 9.51, 12.81, 16.61; IL-1beta 4.80, 6.20, 10.85, 14.51; IL-6: 4.01, 5.90, 11.51 and 14.88 as compared to dexamethasone: 5.29, 2.93, 3.72, respectively (p<0.05).	vitexin	39-46	interleukin 1 alpha	Homo sapiens	175-183
33857595-13	2021	Furthermore, isoorientin, orientin, isovitexin, and vitexin produced significant concentration-dependent inhibition with IC50 values (muM) of COX-2: 7.13, 9.51, 12.81, 16.61; IL-1beta 4.80, 6.20, 10.85, 14.51; IL-6: 4.01, 5.90, 11.51 and 14.88 as compared to dexamethasone: 5.29, 2.93, 3.72, respectively (p<0.05).	vitexin	39-46	interleukin 6	Homo sapiens	210-214
33704405-5	2021	The Western blot analysis suggested that alteration in renal NF-kappaB, IkappaBalpha, nephrin, AMPK, and ACC phosphorylation levels was effectively restored by vitexin treatment.	vitexin	160-167	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	72-84
33915055-6	2021	Furthermore, this study indicated that vitexin alleviated CCH-induced inflammation injuries by reducing the expression of NLRP3, Caspase-1, IL-1beta, IL-6, and cleaved Caspase-3.	vitexin	39-46	caspase 3	Rattus norvegicus	168-177
33915055-6	2021	Furthermore, this study indicated that vitexin alleviated CCH-induced inflammation injuries by reducing the expression of NLRP3, Caspase-1, IL-1beta, IL-6, and cleaved Caspase-3.	vitexin	39-46	NLR family, pyrin domain containing 3	Rattus norvegicus	122-127
33915055-6	2021	Furthermore, this study indicated that vitexin alleviated CCH-induced inflammation injuries by reducing the expression of NLRP3, Caspase-1, IL-1beta, IL-6, and cleaved Caspase-3.	vitexin	39-46	caspase 1	Rattus norvegicus	129-138
33915055-6	2021	Furthermore, this study indicated that vitexin alleviated CCH-induced inflammation injuries by reducing the expression of NLRP3, Caspase-1, IL-1beta, IL-6, and cleaved Caspase-3.	vitexin	39-46	interleukin 1 alpha	Rattus norvegicus	140-148
33915055-6	2021	Furthermore, this study indicated that vitexin alleviated CCH-induced inflammation injuries by reducing the expression of NLRP3, Caspase-1, IL-1beta, IL-6, and cleaved Caspase-3.	vitexin	39-46	interleukin 6	Rattus norvegicus	150-154
33704405-5	2021	The Western blot analysis suggested that alteration in renal NF-kappaB, IkappaBalpha, nephrin, AMPK, and ACC phosphorylation levels was effectively restored by vitexin treatment.	vitexin	160-167	nephrosis 1, nephrin	Mus musculus	86-93
33704405-5	2021	The Western blot analysis suggested that alteration in renal NF-kappaB, IkappaBalpha, nephrin, AMPK, and ACC phosphorylation levels was effectively restored by vitexin treatment.	vitexin	160-167	anterior capsular cataract	Mus musculus	105-108
33704405-7	2021	In conclusion, vitexin suppressed the progression of obesity-induced DN via modulation of NF-kappaB/IkBalpha and AMPK/ACC pathways in an experimental model of HFD-induced DN in C57BL/6J mice.	vitexin	15-22	anterior capsular cataract	Mus musculus	118-121
32980348-8	2020	Vitexin improved insulin signaling as analyzed by the levels of functional proteins in the insulin pathways, viz., insulin receptor (IR), insulin receptor substrate (IRS)-1 and IRS-2, glucose transporter -2, and glucose-stimulated insulin secretion.	vitexin	0-7	insulin receptor	Rattus norvegicus	115-131
33682632-5	2021	This study evaluates a few selective herbal compounds like glucoraphanin, vitexin, niazinin, etc., as a potential inhibitor of the spike protein and 3-chymotrypsin-like protease (3CLpro) or main protease (Mpro) of SARS-COV-2 through in-silico virtual studies such as molecular docking, target analysis, toxicity prediction and ADME prediction and supported by a Molecular-Dynamic simulation.	vitexin	74-81	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	131-136
33682632-5	2021	This study evaluates a few selective herbal compounds like glucoraphanin, vitexin, niazinin, etc., as a potential inhibitor of the spike protein and 3-chymotrypsin-like protease (3CLpro) or main protease (Mpro) of SARS-COV-2 through in-silico virtual studies such as molecular docking, target analysis, toxicity prediction and ADME prediction and supported by a Molecular-Dynamic simulation.	vitexin	74-81	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	205-209
33600185-3	2021	The inhibition against the fluorescent advanced glycation end products was more than 80% at 500 muM vitexin in both bovine serum albumin (BSA)-fructose and BSA-methylglyoxal (MGO) models.	vitexin	100-107	albumin	Homo sapiens	123-136
32980348-8	2020	Vitexin improved insulin signaling as analyzed by the levels of functional proteins in the insulin pathways, viz., insulin receptor (IR), insulin receptor substrate (IRS)-1 and IRS-2, glucose transporter -2, and glucose-stimulated insulin secretion.	vitexin	0-7	insulin receptor	Rattus norvegicus	133-135
32980348-8	2020	Vitexin improved insulin signaling as analyzed by the levels of functional proteins in the insulin pathways, viz., insulin receptor (IR), insulin receptor substrate (IRS)-1 and IRS-2, glucose transporter -2, and glucose-stimulated insulin secretion.	vitexin	0-7	insulin receptor substrate 1	Rattus norvegicus	138-172
32980348-8	2020	Vitexin improved insulin signaling as analyzed by the levels of functional proteins in the insulin pathways, viz., insulin receptor (IR), insulin receptor substrate (IRS)-1 and IRS-2, glucose transporter -2, and glucose-stimulated insulin secretion.	vitexin	0-7	insulin receptor substrate 2	Rattus norvegicus	177-182
33045867-9	2020	Subsequently, activation of MAPK-Nrf2/ARE signaling was readily induced by vitexin treatment, as evidenced by upregulation of antioxidant genes including heme oxygenase 1 (HO-1) and superoxide dismutase (SOD).	vitexin	75-82	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
33045867-9	2020	Subsequently, activation of MAPK-Nrf2/ARE signaling was readily induced by vitexin treatment, as evidenced by upregulation of antioxidant genes including heme oxygenase 1 (HO-1) and superoxide dismutase (SOD).	vitexin	75-82	heme oxygenase 1	Homo sapiens	154-170
33045867-9	2020	Subsequently, activation of MAPK-Nrf2/ARE signaling was readily induced by vitexin treatment, as evidenced by upregulation of antioxidant genes including heme oxygenase 1 (HO-1) and superoxide dismutase (SOD).	vitexin	75-82	heme oxygenase 1	Homo sapiens	172-176
33045867-9	2020	Subsequently, activation of MAPK-Nrf2/ARE signaling was readily induced by vitexin treatment, as evidenced by upregulation of antioxidant genes including heme oxygenase 1 (HO-1) and superoxide dismutase (SOD).	vitexin	75-82	superoxide dismutase 1	Homo sapiens	182-202
33045867-9	2020	Subsequently, activation of MAPK-Nrf2/ARE signaling was readily induced by vitexin treatment, as evidenced by upregulation of antioxidant genes including heme oxygenase 1 (HO-1) and superoxide dismutase (SOD).	vitexin	75-82	superoxide dismutase 1	Homo sapiens	204-207
33045867-10	2020	Knockdown of Nrf2 reversed the protective effect of vitexin on H2O2-induced melanocytes.	vitexin	52-59	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
33543209-9	2020	CONCLUSIONS: VTX significantly inhibited the activation of ERK and p38 signaling pathway.	vitexin	13-16	mitogen-activated protein kinase 1	Homo sapiens	59-62
33045867-0	2020	Vitexin protects melanocytes from oxidative stress via activating MAPK-Nrf2/ARE pathway.	vitexin	0-7	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
33118104-7	2020	Moreover, knockdown of Runx2 attenuated the increase in ALP activity induced by vitexin.	vitexin	80-87	runt related transcription factor 2	Mus musculus	23-28
32544504-7	2020	Moreover, we also found that vitexin treatment could significantly inhibit the expressions of TLR4/NF-kappaB signaling in CSHFD mice.	vitexin	29-36	toll-like receptor 4	Mus musculus	94-98
32544504-7	2020	Moreover, we also found that vitexin treatment could significantly inhibit the expressions of TLR4/NF-kappaB signaling in CSHFD mice.	vitexin	29-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
33543209-9	2020	CONCLUSIONS: VTX significantly inhibited the activation of ERK and p38 signaling pathway.	vitexin	13-16	mitogen-activated protein kinase 14	Homo sapiens	67-70
31677055-0	2020	Vitexin, an inhibitor of hypoxia-inducible factor-1alpha, enhances the radiotherapy sensitization of hyperbaric oxygen on glioma.	vitexin	0-7	hypoxia inducible factor 1, alpha subunit	Mus musculus	25-56
32944531-0	2020	Vitexin suppresses renal cell carcinoma by regulating mTOR pathways.	vitexin	0-7	mechanistic target of rapamycin kinase	Homo sapiens	54-58
32944531-10	2020	Vitexin inhibited growth and induced apoptosis of ACHN and OS-RC-2 cells in a dose-dependent manner, and promoted excessive autophagy by reducing p62 levels and increasing Beclin1 and LC3II levels.	vitexin	0-7	nucleoporin 62	Homo sapiens	146-149
32944531-10	2020	Vitexin inhibited growth and induced apoptosis of ACHN and OS-RC-2 cells in a dose-dependent manner, and promoted excessive autophagy by reducing p62 levels and increasing Beclin1 and LC3II levels.	vitexin	0-7	beclin 1	Homo sapiens	172-179
31677055-1	2020	PURPOSE: Vitexin, an inhibitor of hypoxia-inducible factor (HIF)-1alpha, has anti-tumor effect.	vitexin	9-16	hypoxia inducible factor 1, alpha subunit	Mus musculus	34-71
31677055-11	2020	CONCLUSIONS: Vitexin can cooperate with HBO to sensitize the glioma radiotherapy, and its mechanisms may be correlated to the inhibition of HIF-1alpha protein expression and subsequent decrements of its downstream protein expressions, which finally cause the reduction of antioxidant capacity.	vitexin	13-20	hypoxia inducible factor 1, alpha subunit	Mus musculus	140-150
32004628-12	2020	Vitexin significantly down-regulated the protein expression of TBK1 and IRF3 as well as the mRNA expression of TLR3, TBK1, TRIF and IRF3 while up-regulated the protein expression of TLR4 and IKKalpha.	vitexin	0-7	toll-like receptor 3	Mus musculus	111-115
32004628-12	2020	Vitexin significantly down-regulated the protein expression of TBK1 and IRF3 as well as the mRNA expression of TLR3, TBK1, TRIF and IRF3 while up-regulated the protein expression of TLR4 and IKKalpha.	vitexin	0-7	TANK-binding kinase 1	Mus musculus	117-121
32004628-12	2020	Vitexin significantly down-regulated the protein expression of TBK1 and IRF3 as well as the mRNA expression of TLR3, TBK1, TRIF and IRF3 while up-regulated the protein expression of TLR4 and IKKalpha.	vitexin	0-7	toll-like receptor adaptor molecule 1	Mus musculus	123-127
32004628-12	2020	Vitexin significantly down-regulated the protein expression of TBK1 and IRF3 as well as the mRNA expression of TLR3, TBK1, TRIF and IRF3 while up-regulated the protein expression of TLR4 and IKKalpha.	vitexin	0-7	interferon regulatory factor 3	Mus musculus	132-136
32004628-12	2020	Vitexin significantly down-regulated the protein expression of TBK1 and IRF3 as well as the mRNA expression of TLR3, TBK1, TRIF and IRF3 while up-regulated the protein expression of TLR4 and IKKalpha.	vitexin	0-7	toll-like receptor 4	Mus musculus	182-186
32004628-12	2020	Vitexin significantly down-regulated the protein expression of TBK1 and IRF3 as well as the mRNA expression of TLR3, TBK1, TRIF and IRF3 while up-regulated the protein expression of TLR4 and IKKalpha.	vitexin	0-7	conserved helix-loop-helix ubiquitous kinase	Mus musculus	191-199
32011832-15	2020	Further studies showed that overexpression of miR-409 could significantly promote the effect of vitexin on isoflurane-induced neurotoxicity (p < 0.05).	vitexin	96-103	microRNA 409	Homo sapiens	46-53
32045602-0	2020	Vitexin protects against ethanol-induced liver injury through Sirt1/p53 signaling pathway.	vitexin	0-7	sirtuin 1	Homo sapiens	62-67
32045602-0	2020	Vitexin protects against ethanol-induced liver injury through Sirt1/p53 signaling pathway.	vitexin	0-7	tumor protein p53	Homo sapiens	68-71
32045602-8	2020	In vitro, Vitexin restored cytoactive and inhibited the releasing of AST induced by ethanol in LO2 cell.	vitexin	10-17	solute carrier family 17 member 5	Homo sapiens	69-72
32045602-11	2020	Vitexin supplement restored the decrease of Sirt1/Bcl-2 expression, restrained the elevation of caspase3, cleaved caspse-3, p53 and ac-p53 expression in vivo and in vitro.	vitexin	0-7	sirtuin 1	Homo sapiens	44-49
32045602-11	2020	Vitexin supplement restored the decrease of Sirt1/Bcl-2 expression, restrained the elevation of caspase3, cleaved caspse-3, p53 and ac-p53 expression in vivo and in vitro.	vitexin	0-7	BCL2 apoptosis regulator	Homo sapiens	50-55
32045602-11	2020	Vitexin supplement restored the decrease of Sirt1/Bcl-2 expression, restrained the elevation of caspase3, cleaved caspse-3, p53 and ac-p53 expression in vivo and in vitro.	vitexin	0-7	caspase 3	Homo sapiens	96-104
32045602-11	2020	Vitexin supplement restored the decrease of Sirt1/Bcl-2 expression, restrained the elevation of caspase3, cleaved caspse-3, p53 and ac-p53 expression in vivo and in vitro.	vitexin	0-7	tumor protein p53	Homo sapiens	124-127
32045602-11	2020	Vitexin supplement restored the decrease of Sirt1/Bcl-2 expression, restrained the elevation of caspase3, cleaved caspse-3, p53 and ac-p53 expression in vivo and in vitro.	vitexin	0-7	tumor protein p53	Homo sapiens	135-138
32045602-12	2020	Vitexin has a protective effect against ethanol-induced liver damage, and the underlying mechanism is probably through Sirt1/p53 mediated mitochondrial apoptotic pathway.	vitexin	0-7	sirtuin 1	Homo sapiens	119-124
32045602-12	2020	Vitexin has a protective effect against ethanol-induced liver damage, and the underlying mechanism is probably through Sirt1/p53 mediated mitochondrial apoptotic pathway.	vitexin	0-7	tumor protein p53	Homo sapiens	125-128
32004628-12	2020	Vitexin significantly down-regulated the protein expression of TBK1 and IRF3 as well as the mRNA expression of TLR3, TBK1, TRIF and IRF3 while up-regulated the protein expression of TLR4 and IKKalpha.	vitexin	0-7	TANK-binding kinase 1	Mus musculus	63-67
32004628-12	2020	Vitexin significantly down-regulated the protein expression of TBK1 and IRF3 as well as the mRNA expression of TLR3, TBK1, TRIF and IRF3 while up-regulated the protein expression of TLR4 and IKKalpha.	vitexin	0-7	interferon regulatory factor 3	Mus musculus	72-76
29456715-0	2018	Protective effect of vitexin reduces sevoflurane-induced neuronal apoptosis through HIF-1alpha, VEGF and p38 MAPK signaling pathway in vitro and in newborn rats.	vitexin	21-28	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	84-94
31810123-6	2020	The results indicated that hepatic histopathological changes induced by DSS were normalized by vitexin treatment, administration of vitexin decreased the liver levels of ALT and TC in mice with liver injury and reduced the release amounts of DSS-induced pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1beta.	vitexin	132-139	glutamic pyruvic transaminase, soluble	Mus musculus	170-173
31810123-6	2020	The results indicated that hepatic histopathological changes induced by DSS were normalized by vitexin treatment, administration of vitexin decreased the liver levels of ALT and TC in mice with liver injury and reduced the release amounts of DSS-induced pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1beta.	vitexin	132-139	tumor necrosis factor	Mus musculus	281-290
31810123-6	2020	The results indicated that hepatic histopathological changes induced by DSS were normalized by vitexin treatment, administration of vitexin decreased the liver levels of ALT and TC in mice with liver injury and reduced the release amounts of DSS-induced pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1beta.	vitexin	132-139	interleukin 6	Mus musculus	292-296
31810123-6	2020	The results indicated that hepatic histopathological changes induced by DSS were normalized by vitexin treatment, administration of vitexin decreased the liver levels of ALT and TC in mice with liver injury and reduced the release amounts of DSS-induced pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1beta.	vitexin	132-139	interleukin 1 beta	Mus musculus	301-309
31810123-7	2020	Furthermore, we found that vitexin inhibited the activation of TLR4/NF-kappaB signaling pathway induced by DSS.	vitexin	27-34	toll-like receptor 4	Mus musculus	63-67
31810123-7	2020	Furthermore, we found that vitexin inhibited the activation of TLR4/NF-kappaB signaling pathway induced by DSS.	vitexin	27-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	68-77
30793311-0	2019	Vitexin suppresses RANKL-induced osteoclastogenesis and prevents lipopolysaccharide (LPS)-induced osteolysis.	vitexin	0-7	TNF superfamily member 11	Homo sapiens	19-24
29925377-0	2018	Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1.	vitexin	0-7	solute carrier family 12 member 2	Rattus norvegicus	88-93
29328424-7	2018	The present study also demonstrated that vitexin inhibited RAC-alpha serine/threonine-protein kinase (Akt)/mechanistic target of rapamycin kinase (mTOR) signaling in human glioblastoma cells.	vitexin	41-48	AKT serine/threonine kinase 1	Homo sapiens	102-105
29328424-7	2018	The present study also demonstrated that vitexin inhibited RAC-alpha serine/threonine-protein kinase (Akt)/mechanistic target of rapamycin kinase (mTOR) signaling in human glioblastoma cells.	vitexin	41-48	mechanistic target of rapamycin kinase	Homo sapiens	147-151
29456715-0	2018	Protective effect of vitexin reduces sevoflurane-induced neuronal apoptosis through HIF-1alpha, VEGF and p38 MAPK signaling pathway in vitro and in newborn rats.	vitexin	21-28	vascular endothelial growth factor A	Rattus norvegicus	96-100
29456715-0	2018	Protective effect of vitexin reduces sevoflurane-induced neuronal apoptosis through HIF-1alpha, VEGF and p38 MAPK signaling pathway in vitro and in newborn rats.	vitexin	21-28	mitogen activated protein kinase 14	Rattus norvegicus	105-108
29456715-5	2018	Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1alpha subunit (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated-p38 MAP kinase (p38) protein expression in sevoflurane-induced newborn rat.	vitexin	49-56	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	65-104
29456715-5	2018	Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1alpha subunit (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated-p38 MAP kinase (p38) protein expression in sevoflurane-induced newborn rat.	vitexin	49-56	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	106-116
29456715-5	2018	Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1alpha subunit (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated-p38 MAP kinase (p38) protein expression in sevoflurane-induced newborn rat.	vitexin	49-56	vascular endothelial growth factor A	Rattus norvegicus	122-156
29456715-5	2018	Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1alpha subunit (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated-p38 MAP kinase (p38) protein expression in sevoflurane-induced newborn rat.	vitexin	49-56	vascular endothelial growth factor A	Rattus norvegicus	158-162
29456715-5	2018	Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1alpha subunit (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated-p38 MAP kinase (p38) protein expression in sevoflurane-induced newborn rat.	vitexin	49-56	mitogen activated protein kinase 14	Rattus norvegicus	214-217
29456715-5	2018	Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1alpha subunit (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated-p38 MAP kinase (p38) protein expression in sevoflurane-induced newborn rat.	vitexin	49-56	mitogen activated protein kinase 14	Rattus norvegicus	230-233
27878303-5	2016	In addition, treatment with vitexin suppressed isoflurane-induced caspase-3 activation and increased beta-secretase 1 levels in PC12 cells.	vitexin	28-35	caspase 3	Rattus norvegicus	66-75
30087790-3	2017	To address the anti-inflammatory role of flavonoids, in the present study, we investigated the effects of the flavonoids quercetin and vitexin on the stimulus-induced nitric oxide (NO), TNF-alpha, and MPO productions in human neutrophils.	vitexin	135-142	myeloperoxidase	Homo sapiens	201-204
28098903-0	2017	Vitexin alleviates lipopolysaccharide-induced islet cell injury by inhibiting HMGB1 release.	vitexin	0-7	high mobility group box 1	Rattus norvegicus	78-83
29588573-0	2018	Vitexin protects dopaminergic neurons in MPTP-induced Parkinson"s disease through PI3K/Akt signaling pathway.	vitexin	0-7	AKT serine/threonine kinase 1	Homo sapiens	87-90
29588573-7	2018	Vit also enhanced the activation of PI3K and Akt and suppressed the ratio of Bax/Bcl-2 and caspase-3 activity in MPTP-treated mice.	vitexin	0-3	thymoma viral proto-oncogene 1	Mus musculus	45-48
29588573-7	2018	Vit also enhanced the activation of PI3K and Akt and suppressed the ratio of Bax/Bcl-2 and caspase-3 activity in MPTP-treated mice.	vitexin	0-3	BCL2-associated X protein	Mus musculus	77-80
29588573-7	2018	Vit also enhanced the activation of PI3K and Akt and suppressed the ratio of Bax/Bcl-2 and caspase-3 activity in MPTP-treated mice.	vitexin	0-3	B cell leukemia/lymphoma 2	Mus musculus	81-86
29588573-7	2018	Vit also enhanced the activation of PI3K and Akt and suppressed the ratio of Bax/Bcl-2 and caspase-3 activity in MPTP-treated mice.	vitexin	0-3	caspase 3	Mus musculus	91-100
29588573-8	2018	Conclusion: Taken together, this study demonstrated that Vit protected dopaminergic neurons against MPP+/MPTP-induced neurotoxicity through the activation of PI3K/Akt signaling pathway.	vitexin	57-60	thymoma viral proto-oncogene 1	Mus musculus	163-166
27878303-5	2016	In addition, treatment with vitexin suppressed isoflurane-induced caspase-3 activation and increased beta-secretase 1 levels in PC12 cells.	vitexin	28-35	beta-secretase 1	Rattus norvegicus	101-117
27470339-8	2016	In addition, the mRNA expression of N-methyl-d-aspartate receptor (NMDAR), mGluR1 and mGlu5 was significantly (P&lt;=0.05) inhibited by AP8CG and CA in a lower dose.	vitexin	136-141	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	36-65
27470339-8	2016	In addition, the mRNA expression of N-methyl-d-aspartate receptor (NMDAR), mGluR1 and mGlu5 was significantly (P&lt;=0.05) inhibited by AP8CG and CA in a lower dose.	vitexin	136-141	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	67-72
27470339-8	2016	In addition, the mRNA expression of N-methyl-d-aspartate receptor (NMDAR), mGluR1 and mGlu5 was significantly (P&lt;=0.05) inhibited by AP8CG and CA in a lower dose.	vitexin	136-141	glutamate receptor, metabotropic 1	Mus musculus	75-81
27470339-10	2016	Our result shows that AP8CG and CA selectively inhibit NMDAR, mGluR1 and mGlu5 expression.	vitexin	22-27	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	55-60
27470339-10	2016	Our result shows that AP8CG and CA selectively inhibit NMDAR, mGluR1 and mGlu5 expression.	vitexin	22-27	glutamate receptor, metabotropic 1	Mus musculus	62-68
26187393-2	2015	Vitexin (5, 7, 4-trihydroxyflavone-8-glucoside), an HIF-1alpha inhibitor, is a c-glycosylated flavone that has been identified in medicinal plants.	vitexin	0-7	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	52-62
26187393-10	2015	Vitexin (45 mg/kg) ameliorated brain edema, BBB disruption and neuronal cell death; Upregulation of HIF-1alpha by dimethyloxalylglycine (DMOG) increased the BBB permeability and brain edema compared to HI alone.	vitexin	0-7	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	100-110
18457368-7	2008	Exposure to anoxia or vitexin preconditioning significantly increased the phospho-ERK level, and the increase was markedly inhibited by PD98059, an inhibitor of the upstream kinase of ERK.	vitexin	22-29	Eph receptor B1	Rattus norvegicus	82-85
18457368-7	2008	Exposure to anoxia or vitexin preconditioning significantly increased the phospho-ERK level, and the increase was markedly inhibited by PD98059, an inhibitor of the upstream kinase of ERK.	vitexin	22-29	Eph receptor B1	Rattus norvegicus	184-187
10784427-5	2000	Methyl quadrangularates A (30) and N (32), norquadrangularic acid B (31) and vitexin (40) also showed potent inhibition on TNF-alpha-induced cell death with IC50 values of 45.7, 89.3, 67.6 and 40.1 microM, respectively.	vitexin	77-84	tumor necrosis factor	Mus musculus	123-132
34953801-9	2022	In addition, vitexin enhanced the phosphorylation of AMPK, AKT and GSK-3beta.	vitexin	13-20	thymoma viral proto-oncogene 1	Mus musculus	59-62
34953801-9	2022	In addition, vitexin enhanced the phosphorylation of AMPK, AKT and GSK-3beta.	vitexin	13-20	glycogen synthase kinase 3 alpha	Mus musculus	67-76
35436985-8	2022	To prove the translational implication of our mechanistic findings, we identified vitexin as a pharmacological agent that disrupts FAM134B-BiP complex, inhibits ER-phagy, and potently suppresses breast cancer progression in vivo.	vitexin	82-89	reticulophagy regulator 1	Homo sapiens	131-138
35436985-8	2022	To prove the translational implication of our mechanistic findings, we identified vitexin as a pharmacological agent that disrupts FAM134B-BiP complex, inhibits ER-phagy, and potently suppresses breast cancer progression in vivo.	vitexin	82-89	growth differentiation factor 10	Homo sapiens	139-142
35534452-0	2022	Erratum: Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/AKT/mTOR/HIF-1alpha Signaling Pathway.	vitexin	9-16	high mobility group box 1	Homo sapiens	71-76
35534452-0	2022	Erratum: Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/AKT/mTOR/HIF-1alpha Signaling Pathway.	vitexin	9-16	AKT serine/threonine kinase 1	Homo sapiens	111-114
35534452-0	2022	Erratum: Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/AKT/mTOR/HIF-1alpha Signaling Pathway.	vitexin	9-16	mechanistic target of rapamycin kinase	Homo sapiens	115-119
35534452-0	2022	Erratum: Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/AKT/mTOR/HIF-1alpha Signaling Pathway.	vitexin	9-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-130
35254859-13	2022	In the meantime, vitexin administration decreased reactive oxygen species (ROS) production and malondialdehyde (MDA) content and increased superoxide dismutase (SOD) activity in HG-induced HUVECs.	vitexin	17-24	superoxide dismutase 1	Homo sapiens	139-159
35254859-13	2022	In the meantime, vitexin administration decreased reactive oxygen species (ROS) production and malondialdehyde (MDA) content and increased superoxide dismutase (SOD) activity in HG-induced HUVECs.	vitexin	17-24	superoxide dismutase 1	Homo sapiens	161-164
34810252-4	2021	Treatment with vitexin suppressed the endothelial inflammation induced by OS or tumor necrosis factor-alpha.	vitexin	15-22	tumor necrosis factor	Mus musculus	80-107
34810252-8	2021	OS induced APEX1 nuclear translocation, which was inhibited by vitexin.	vitexin	63-70	apurinic/apyrimidinic endonuclease 1	Mus musculus	11-16
34257823-0	2021	Vitexin Mitigates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Mitochondrial Dysfunction via Epac1-Rap1 Signaling.	vitexin	0-7	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	109-114
34090414-7	2021	RESULTS: The present study reveals that both vitexin and donepezil are able to bind at the close proximity of LPS binding site located at the TLR4/MD-2 complex with the binding energy of - 4.35 and - 9.14 kcal/mol, respectively.	vitexin	45-52	toll like receptor 4	Homo sapiens	142-146
34090414-8	2021	During molecular dynamic simulations, both vitexin and donepezil formed stable complex with TLR4/MD-2 throughout the 100 ns time length with the root mean square deviation (RMSD) values of 2.5 A and 4.0 A, respectively.	vitexin	43-50	toll like receptor 4	Homo sapiens	92-96
35281458-9	2022	The results of the present study demonstrate that vitexin inhibits the proliferation and invasion and induces the apoptosis of glioblastoma U251 cells through suppressing the JAK/STAT3 signaling pathway, and vitexin may be a promising potential agent for the chemotherapy of glioblastoma.	vitexin	50-57	signal transducer and activator of transcription 3	Homo sapiens	179-184