PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34424822-2 2021 In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) and usnic acid (UA) on purified AR and SDH enzymes were determined. usnic acid 86-96 L-iditol 2-dehydrogenase Ovis aries 121-124 16414064-5 2006 Based on the calculated values of the free energy of mixing, we note that the DBPC/UA and DPPC/UA systems present the best mixed character at low pressures and when the molar fraction of the UA is 0.5; at that relative concentration and at low values of the external pressure, the UA molecules can better mix and interact with the phospholipid molecules. usnic acid 83-85 Y-box binding protein 2 Homo sapiens 78-82 16169175-9 2006 The administration of UA and ranitidine increased the cNOS activity and lowered the iNOS activity as compared with indomethacin-treated group. usnic acid 22-24 nitric oxide synthase 3 Rattus norvegicus 54-58 16169175-9 2006 The administration of UA and ranitidine increased the cNOS activity and lowered the iNOS activity as compared with indomethacin-treated group. usnic acid 22-24 nitric oxide synthase 2 Rattus norvegicus 84-88 8726330-5 1996 (+)Usnic acid at a concentration of 0.75 microM inhibited ADP/O ratio by 50%, caused maximal stimulation of both state-4 respiration (100%) and ATPase activity (300%). usnic acid 0-13 dynein, axonemal, heavy chain 8 Mus musculus 144-150 30142660-0 2019 Inhibitory Effect of New Semisynthetic Usnic Acid Derivatives on Human Tyrosyl-DNA Phosphodiesterase 1. usnic acid 39-49 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 71-102 30142660-3 2019 In this context, a series of new usnic acid derivatives comprising a terpenoid moiety were synthesized, and their ability to inhibit the catalytic activity of the human DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 was investigated. usnic acid 33-43 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 187-218 34768766-0 2021 New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1. usnic acid 44-54 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 101-105 34768766-0 2021 New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1. usnic acid 44-54 tyrosyl-DNA phosphodiesterase 2 Homo sapiens 107-111 34768766-0 2021 New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1. usnic acid 44-54 poly(ADP-ribose) polymerase 1 Homo sapiens 116-121 16096427-3 2005 Usnic acid, a normal component of lichens, showed activity against the wild-type p53 breast cancer cell line MCF7 as well as the non-functional p53 breast cancer cell line MDA-MB-231 and the lung cancer cell line H1299 (null for p53). usnic acid 0-10 tumor protein p53 Homo sapiens 81-84 16096427-3 2005 Usnic acid, a normal component of lichens, showed activity against the wild-type p53 breast cancer cell line MCF7 as well as the non-functional p53 breast cancer cell line MDA-MB-231 and the lung cancer cell line H1299 (null for p53). usnic acid 0-10 tumor protein p53 Homo sapiens 144-147 16096427-3 2005 Usnic acid, a normal component of lichens, showed activity against the wild-type p53 breast cancer cell line MCF7 as well as the non-functional p53 breast cancer cell line MDA-MB-231 and the lung cancer cell line H1299 (null for p53). usnic acid 0-10 tumor protein p53 Homo sapiens 144-147 16096427-4 2005 In MCF7 cells treated with usnic acid, although there was an accumulation of p53 and p21 proteins, the transcriptional activity of p53 remained unaffected. usnic acid 27-37 tumor protein p53 Homo sapiens 77-80 16096427-4 2005 In MCF7 cells treated with usnic acid, although there was an accumulation of p53 and p21 proteins, the transcriptional activity of p53 remained unaffected. usnic acid 27-37 H3 histone pseudogene 16 Homo sapiens 85-88 16096427-4 2005 In MCF7 cells treated with usnic acid, although there was an accumulation of p53 and p21 proteins, the transcriptional activity of p53 remained unaffected. usnic acid 27-37 tumor protein p53 Homo sapiens 131-134 16096427-6 2005 The property of usnic acid as a non-genotoxic anti-cancer agent that works in a p53-independent manner makes it a potential candidate for novel cancer therapy. usnic acid 16-26 tumor protein p53 Homo sapiens 80-83 15513745-8 2004 The cytotoxicity of free and encapsulated usnic acid was evaluated against HEp-2 cells using the MTT method. usnic acid 42-52 histocompatibility 51 Mus musculus 75-78 34370156-4 2021 In the present work, we showed a sensitizing effect of an enamine derivative of usnic acid (when administered intragastrically) on Lewis lung carcinoma in mice in combination with topotecan (TPT, Top1 poison used in the clinic). usnic acid 80-90 topoisomerase (DNA) I Mus musculus 196-200 34424822-2 2021 In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) and usnic acid (UA) on purified AR and SDH enzymes were determined. usnic acid 98-100 L-iditol 2-dehydrogenase Ovis aries 121-124 33970512-0 2021 Usnic acid suppresses cervical cancer cell proliferation by inhibiting PD-L1 expression and enhancing T-lymphocyte tumor-killing activity. usnic acid 0-10 CD274 molecule Homo sapiens 71-76 34356597-0 2021 New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. usnic acid 44-54 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 88-119 34356597-2 2021 Previously, we found that UA derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1 (TDP1). usnic acid 26-28 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 69-100 34356597-2 2021 Previously, we found that UA derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1 (TDP1). usnic acid 26-28 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 102-106 33967344-8 2021 In addition, Usnic acid revealed its ability to combat the interaction of RBD of SGP to angiotensin-converting enzyme-2 in docking analysis. usnic acid 13-23 angiotensin converting enzyme 2 Homo sapiens 88-119 33635505-0 2021 (+)-Usnic acid modulates the Nrf2-ARE pathway in FaDu hypopharyngeal carcinoma cells. usnic acid 4-14 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 33635505-1 2021 Naturally occurring phytochemicals of different origin and structure, arctigenin, bergenin, usnic acid and xanthohumol, were shown to affect Nrf2 pathway in the context of various diseases, but their effect on this pathway in cancer cells was not extensively investigated. usnic acid 92-102 NFE2 like bZIP transcription factor 2 Homo sapiens 141-145 35257985-7 2022 An increase in the band intensity of phospholipids, increased distribution of lipid and change in membrane potential was noted in UA treated cells, which was confirmed by externalization of phosphatidylserine to the outer membrane by annexin V-FITC/PI assay. usnic acid 130-132 annexin A5 Homo sapiens 234-243 33635505-4 2021 Consequently, (+)-usnic acid enhanced the transcription and translation of Nrf2 target genes: NQO1, SOD, and to a lesser extent, GSTP. usnic acid 18-28 NFE2 like bZIP transcription factor 2 Homo sapiens 75-79 33635505-4 2021 Consequently, (+)-usnic acid enhanced the transcription and translation of Nrf2 target genes: NQO1, SOD, and to a lesser extent, GSTP. usnic acid 18-28 NAD(P)H quinone dehydrogenase 1 Homo sapiens 94-98 33635505-4 2021 Consequently, (+)-usnic acid enhanced the transcription and translation of Nrf2 target genes: NQO1, SOD, and to a lesser extent, GSTP. usnic acid 18-28 superoxide dismutase 1 Homo sapiens 100-103 33635505-4 2021 Consequently, (+)-usnic acid enhanced the transcription and translation of Nrf2 target genes: NQO1, SOD, and to a lesser extent, GSTP. usnic acid 18-28 glutathione S-transferase pi 1 Homo sapiens 129-133 33635505-5 2021 The treatment of FaDu cells with (+)-usnic acid decreased both GSK-3beta transcript and protein level, indicating its possible involvement in Nrf2 activation. usnic acid 37-47 glycogen synthase kinase 3 alpha Homo sapiens 63-72 33635505-5 2021 The treatment of FaDu cells with (+)-usnic acid decreased both GSK-3beta transcript and protein level, indicating its possible involvement in Nrf2 activation. usnic acid 37-47 NFE2 like bZIP transcription factor 2 Homo sapiens 142-146 33635505-7 2021 (+)-Usnic acid tended to increase the percentage of early apoptotic cells and LC3 protein, autophagy marker. usnic acid 4-14 microtubule associated protein 1 light chain 3 alpha Homo sapiens 78-81 33635505-9 2021 In summary, the results of this study indicate that low concentrations of (+)-usnic acid activate Nrf2 transcription factor, most probably as a result of ROS accumulation, but do not lead to FaDu hypopharyngeal carcinoma cells death. usnic acid 78-88 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 33970512-5 2021 In this work, we first observed that usnic acid decreased the expression of PD-L1 in HeLa cells and enhanced the cytotoxicity of co-cultured T cells toward tumor cells. usnic acid 37-47 CD274 molecule Homo sapiens 76-81 33970512-6 2021 Usnic acid inhibited PD-L1 protein synthesis by reducing STAT3 and RAS pathways cooperatively. usnic acid 0-10 CD274 molecule Homo sapiens 21-26 33970512-6 2021 Usnic acid inhibited PD-L1 protein synthesis by reducing STAT3 and RAS pathways cooperatively. usnic acid 0-10 signal transducer and activator of transcription 3 Homo sapiens 57-62 33970512-7 2021 It was subsequently shown that usnic acid induced MiT/TFE nuclear translocation through the suppression of mTOR signaling pathways, and promoted the biogenesis of lysosomes and the translocation of PD-L1 to the lysosomes for proteolysis. usnic acid 31-41 mechanistic target of rapamycin kinase Homo sapiens 107-111 33970512-7 2021 It was subsequently shown that usnic acid induced MiT/TFE nuclear translocation through the suppression of mTOR signaling pathways, and promoted the biogenesis of lysosomes and the translocation of PD-L1 to the lysosomes for proteolysis. usnic acid 31-41 CD274 molecule Homo sapiens 198-203 33970512-8 2021 Furthermore, usnic acid inhibited cell proliferation, angiogenesis, migration, and invasion, respectively, by downregulating PD-L1, thereby inhibiting tumor growth. usnic acid 13-23 CD274 molecule Homo sapiens 125-130 33970512-9 2021 Taken together, our results show that usnic acid is an effective inhibitor of PD-L1 and our study provide novel insights into the mechanism of its anticancer targeted therapy. usnic acid 38-48 CD274 molecule Homo sapiens 78-83 33538053-0 2021 alpha-Glucosidase Inhibition by Usnic Acid Derivatives. usnic acid 32-42 sucrase-isomaltase Homo sapiens 0-17 33485970-0 2021 PORIMIN: The Key to (+)-Usnic Acid-Induced Liver Toxicity and Oncotic Cell Death in Normal Human L02 Liver Cells. usnic acid 24-34 transmembrane protein 123 Homo sapiens 0-7 33485970-11 2021 Comparisons between transfected and non-transfected cells were applied for the elucidation of the role of porimin in UA-induced hepatotoxicity. usnic acid 117-119 transmembrane protein 123 Mus musculus 106-113 33022354-4 2021 First, the interactions of UA on acetylcholinesterase (AChE) was assessed by molecular docking and its inhibitory capability on AChE was assessed in vitro. usnic acid 27-29 acetylcholinesterase Mus musculus 55-59 33022354-4 2021 First, the interactions of UA on acetylcholinesterase (AChE) was assessed by molecular docking and its inhibitory capability on AChE was assessed in vitro. usnic acid 27-29 acetylcholinesterase Mus musculus 128-132 33006536-0 2021 Usnic Acid Inhibits Proliferation and Migration through ATM Mediated DNA Damage Response in RKO Colorectal Cancer Cell. usnic acid 0-10 ATM serine/threonine kinase Homo sapiens 56-59 30980508-0 2019 Synergistic effects of hormone therapy drugs and usnic acid on hormone receptor-positive breast and prostate cancer cells. usnic acid 49-59 nuclear receptor subfamily 4 group A member 1 Homo sapiens 63-79 32963745-10 2020 Results: Usnic acid significantly reduced caspase-3, glial fibrillary acidic protein- positive and ionized calcium-binding adaptor molecule 1-positive cells (P<0.001) and enhanced spatial memory disorders (P<0.05) due to brain ischemia. usnic acid 9-19 caspase 3 Rattus norvegicus 42-51 32963745-10 2020 Results: Usnic acid significantly reduced caspase-3, glial fibrillary acidic protein- positive and ionized calcium-binding adaptor molecule 1-positive cells (P<0.001) and enhanced spatial memory disorders (P<0.05) due to brain ischemia. usnic acid 9-19 glial fibrillary acidic protein Rattus norvegicus 53-84 31715134-0 2020 Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and gamma-H2A.X phosphorylation. usnic acid 0-10 protein kinase, DNA-activated, catalytic subunit Homo sapiens 125-133 31715134-3 2020 Usnic acid (10-25 muM) treatment to these cells caused a significant increase in mitochondrial membrane depolarization and apoptotic cells. usnic acid 0-10 latexin Homo sapiens 18-21 31715134-9 2020 In addition, the non-toxic concentrations (1-10 muM) of usnic acid inhibited colony forming potential of AGS cells indicating its anti-proliferation activity. usnic acid 56-66 latexin Homo sapiens 48-51 31715134-11 2020 Collectively, these results for the first time demonstrated the selective apoptotic effect of usnic acid (10-25 muM) through ROS generation and DNA damage on human gastric cancer cells accompanied with upregulation of gammaH2A.X (Ser139) phosphorylation, DNA-PKcs and p53. usnic acid 94-104 latexin Homo sapiens 112-115 31715134-11 2020 Collectively, these results for the first time demonstrated the selective apoptotic effect of usnic acid (10-25 muM) through ROS generation and DNA damage on human gastric cancer cells accompanied with upregulation of gammaH2A.X (Ser139) phosphorylation, DNA-PKcs and p53. usnic acid 94-104 protein kinase, DNA-activated, catalytic subunit Homo sapiens 255-263 31715134-11 2020 Collectively, these results for the first time demonstrated the selective apoptotic effect of usnic acid (10-25 muM) through ROS generation and DNA damage on human gastric cancer cells accompanied with upregulation of gammaH2A.X (Ser139) phosphorylation, DNA-PKcs and p53. usnic acid 94-104 tumor protein p53 Homo sapiens 268-271 31619021-0 2019 New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors. usnic acid 37-47 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 58-62 31619021-3 2019 A new set of usnic acid derivatives with hydrazonothiazole pharmacophore moieties were synthesized and evaluated as Tdp1 inhibitors. usnic acid 13-23 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 116-120 32366289-0 2020 miR-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting Bcl2. usnic acid 23-33 microRNA 185 Homo sapiens 0-7 32366289-0 2020 miR-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting Bcl2. usnic acid 23-33 BCL2 apoptosis regulator Homo sapiens 119-123 32366289-3 2020 The aim of this study was to determine the effect of usnic acid response-miR-185-5p on proliferation in the breast cancer cell and to determine its relationship with apoptosis pathway. usnic acid 53-63 microRNA 185 Homo sapiens 73-80 32326366-1 2020 (+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma. usnic acid 4-14 NFE2 like bZIP transcription factor 2 Homo sapiens 110-114 31549595-11 2020 We found that usnic acid treatment caused significant changes in expression of hsa-miR-5006-5p, hsa-miR-892c-3p, hsa-miR-4430, hsa-miR-5194, hsa-miR-3198, hsa-miR-3171, hsa-miR-933 and hsa-miR-185-3p in breast cancer cells. usnic acid 14-24 microRNA 5006 Homo sapiens 83-91 31549595-11 2020 We found that usnic acid treatment caused significant changes in expression of hsa-miR-5006-5p, hsa-miR-892c-3p, hsa-miR-4430, hsa-miR-5194, hsa-miR-3198, hsa-miR-3171, hsa-miR-933 and hsa-miR-185-3p in breast cancer cells. usnic acid 14-24 microRNA 4430 Homo sapiens 117-125 31549595-11 2020 We found that usnic acid treatment caused significant changes in expression of hsa-miR-5006-5p, hsa-miR-892c-3p, hsa-miR-4430, hsa-miR-5194, hsa-miR-3198, hsa-miR-3171, hsa-miR-933 and hsa-miR-185-3p in breast cancer cells. usnic acid 14-24 microRNA 5194 Homo sapiens 131-139 31549595-11 2020 We found that usnic acid treatment caused significant changes in expression of hsa-miR-5006-5p, hsa-miR-892c-3p, hsa-miR-4430, hsa-miR-5194, hsa-miR-3198, hsa-miR-3171, hsa-miR-933 and hsa-miR-185-3p in breast cancer cells. usnic acid 14-24 microRNA 3198-1 Homo sapiens 145-153 31549595-11 2020 We found that usnic acid treatment caused significant changes in expression of hsa-miR-5006-5p, hsa-miR-892c-3p, hsa-miR-4430, hsa-miR-5194, hsa-miR-3198, hsa-miR-3171, hsa-miR-933 and hsa-miR-185-3p in breast cancer cells. usnic acid 14-24 microRNA 3171 Homo sapiens 159-167 31549595-11 2020 We found that usnic acid treatment caused significant changes in expression of hsa-miR-5006-5p, hsa-miR-892c-3p, hsa-miR-4430, hsa-miR-5194, hsa-miR-3198, hsa-miR-3171, hsa-miR-933 and hsa-miR-185-3p in breast cancer cells. usnic acid 14-24 microRNA 933 Homo sapiens 169-180 31549595-11 2020 We found that usnic acid treatment caused significant changes in expression of hsa-miR-5006-5p, hsa-miR-892c-3p, hsa-miR-4430, hsa-miR-5194, hsa-miR-3198, hsa-miR-3171, hsa-miR-933 and hsa-miR-185-3p in breast cancer cells. usnic acid 14-24 microRNA 185 Homo sapiens 185-196 31832335-5 2019 Also, the inhibition effects of usnic acid were tested against some metabolic enzymes including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) linked to neurodegenerative diseases. usnic acid 32-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 31832335-5 2019 Also, the inhibition effects of usnic acid were tested against some metabolic enzymes including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) linked to neurodegenerative diseases. usnic acid 32-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 31832335-5 2019 Also, the inhibition effects of usnic acid were tested against some metabolic enzymes including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) linked to neurodegenerative diseases. usnic acid 32-42 butyrylcholinesterase Homo sapiens 128-149 31832335-5 2019 Also, the inhibition effects of usnic acid were tested against some metabolic enzymes including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) linked to neurodegenerative diseases. usnic acid 32-42 butyrylcholinesterase Homo sapiens 151-155 31832335-8 2019 Furthermore, usnic acid showed the potent inhibition profiles against AChE (IC50: 1.273 nM) and BChE (IC50: 0.239 nM) enzymes. usnic acid 13-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 31832335-8 2019 Furthermore, usnic acid showed the potent inhibition profiles against AChE (IC50: 1.273 nM) and BChE (IC50: 0.239 nM) enzymes. usnic acid 13-23 butyrylcholinesterase Homo sapiens 96-100 31200288-0 2019 Discovery of novel (+)-Usnic acid derivatives as potential anti-leukemia agents with pan-Pim kinases inhibitory activity. usnic acid 23-33 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 89-92 30980508-1 2019 The aim of this study was to investigate the combined effects of usnic acid (UA) and Tamoxifen (Tam) or Enzalutamide (Enz) on hormone receptor-positive breast and prostate cancer (BC and PC), respectively. usnic acid 65-75 nuclear receptor subfamily 4 group A member 1 Homo sapiens 126-142 30980508-1 2019 The aim of this study was to investigate the combined effects of usnic acid (UA) and Tamoxifen (Tam) or Enzalutamide (Enz) on hormone receptor-positive breast and prostate cancer (BC and PC), respectively. usnic acid 77-79 nuclear receptor subfamily 4 group A member 1 Homo sapiens 126-142 30322046-6 2018 In this study, we investigated whether usnic acid could affect RANKL-mediated osteoclastogenesis. usnic acid 39-49 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 63-68 30827223-6 2019 METHODS: UA and CA were tested in various concentrations against human GST, PON1, and GR activity in vitro and they reduced human GST, PON1, and GR activity. usnic acid 9-11 glutathione S-transferase kappa 1 Homo sapiens 71-74 30827223-6 2019 METHODS: UA and CA were tested in various concentrations against human GST, PON1, and GR activity in vitro and they reduced human GST, PON1, and GR activity. usnic acid 9-11 paraoxonase 1 Homo sapiens 76-80 30827223-6 2019 METHODS: UA and CA were tested in various concentrations against human GST, PON1, and GR activity in vitro and they reduced human GST, PON1, and GR activity. usnic acid 9-11 glutathione-disulfide reductase Homo sapiens 86-88 30827223-6 2019 METHODS: UA and CA were tested in various concentrations against human GST, PON1, and GR activity in vitro and they reduced human GST, PON1, and GR activity. usnic acid 9-11 glutathione S-transferase kappa 1 Homo sapiens 130-133 30827223-6 2019 METHODS: UA and CA were tested in various concentrations against human GST, PON1, and GR activity in vitro and they reduced human GST, PON1, and GR activity. usnic acid 9-11 paraoxonase 1 Homo sapiens 135-139 30827223-6 2019 METHODS: UA and CA were tested in various concentrations against human GST, PON1, and GR activity in vitro and they reduced human GST, PON1, and GR activity. usnic acid 9-11 glutathione-disulfide reductase Homo sapiens 145-147 30827223-9 2019 UA and CA showed competitive inhibition for GR and GST enzymes, while they exhibited non-competitive inhibition for PON1. usnic acid 0-2 glutathione-disulfide reductase Homo sapiens 44-46 30827223-9 2019 UA and CA showed competitive inhibition for GR and GST enzymes, while they exhibited non-competitive inhibition for PON1. usnic acid 0-2 glutathione S-transferase kappa 1 Homo sapiens 51-54 29920769-1 2018 In a conventional Mannich reaction using piperidine, hydroxypiperidines, morpholine, and N-methylpiperazine with usnic acid, a deacetylation was observed resulting in a substitution at C-2, a loss of an acetyl group, and a Mannich base with a stabilized enol. usnic acid 113-123 complement C2 Homo sapiens 185-188 30322046-7 2018 Usnic acid significantly inhibited RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1, a master regulator of osteoclastogenesis. usnic acid 0-10 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 35-40 30322046-7 2018 Usnic acid significantly inhibited RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1, a master regulator of osteoclastogenesis. usnic acid 0-10 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 Mus musculus 148-154 29374767-9 2018 In vivo, compared to mice treated with 5-FU alone, UA treatment was significantly more effective in suppressing the tumor growth without affecting body weight, and in regulating the amount of Bax and Bcl2 in tumor tissues. usnic acid 51-53 BCL2-associated X protein Mus musculus 192-195 30298093-0 2018 (+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer. usnic acid 0-14 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 37-42 30298093-5 2018 (+)-usnic acid [(+)-UA], isolated from lichens, has two major functions including induction of proton shuttle and targeting inhibition of mTOR. usnic acid 0-14 mechanistic target of rapamycin kinase Homo sapiens 138-142 30076000-0 2018 Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors. usnic acid 77-87 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 105-109 30076000-4 2018 Twenty nine derivatives of (+)-usnic acid were tested for in vitro Tdp1 inhibitory activity using a fluorescent-based assay. usnic acid 27-41 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 67-71 29374767-9 2018 In vivo, compared to mice treated with 5-FU alone, UA treatment was significantly more effective in suppressing the tumor growth without affecting body weight, and in regulating the amount of Bax and Bcl2 in tumor tissues. usnic acid 51-53 B cell leukemia/lymphoma 2 Mus musculus 200-204 27369375-0 2017 Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells. usnic acid 44-54 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 28284148-6 2017 UA combined with BLM was significantly more effective than BLM alone in inhibiting the tumor growth, arresting the cell cycle at G0/G1 phase, and promoting the cleaved caspase-3 and cleaved caspase-8 activities to induce cancer cellular apoptosis. usnic acid 0-2 caspase 8 Mus musculus 190-199 28284148-8 2017 Furthermore, UA effectively moderated the histopathological changes, reduced the content of MDA, HYP, TNF-alpha, IL-1beta, IL-6 and TGF-beta1, and increased the level of SOD when combined with BLM in lung tissues of H22-bearing mice, which was believed to be related to the inhibition on the protein level of p-Smad2/3 and enhancement of Smad7 expression. usnic acid 13-15 phosphate regulating endopeptidase homolog, X-linked Mus musculus 97-100 28284148-8 2017 Furthermore, UA effectively moderated the histopathological changes, reduced the content of MDA, HYP, TNF-alpha, IL-1beta, IL-6 and TGF-beta1, and increased the level of SOD when combined with BLM in lung tissues of H22-bearing mice, which was believed to be related to the inhibition on the protein level of p-Smad2/3 and enhancement of Smad7 expression. usnic acid 13-15 tumor necrosis factor Mus musculus 102-111 28284148-8 2017 Furthermore, UA effectively moderated the histopathological changes, reduced the content of MDA, HYP, TNF-alpha, IL-1beta, IL-6 and TGF-beta1, and increased the level of SOD when combined with BLM in lung tissues of H22-bearing mice, which was believed to be related to the inhibition on the protein level of p-Smad2/3 and enhancement of Smad7 expression. usnic acid 13-15 interleukin 1 beta Mus musculus 113-121 28284148-8 2017 Furthermore, UA effectively moderated the histopathological changes, reduced the content of MDA, HYP, TNF-alpha, IL-1beta, IL-6 and TGF-beta1, and increased the level of SOD when combined with BLM in lung tissues of H22-bearing mice, which was believed to be related to the inhibition on the protein level of p-Smad2/3 and enhancement of Smad7 expression. usnic acid 13-15 interleukin 6 Mus musculus 123-127 28284148-8 2017 Furthermore, UA effectively moderated the histopathological changes, reduced the content of MDA, HYP, TNF-alpha, IL-1beta, IL-6 and TGF-beta1, and increased the level of SOD when combined with BLM in lung tissues of H22-bearing mice, which was believed to be related to the inhibition on the protein level of p-Smad2/3 and enhancement of Smad7 expression. usnic acid 13-15 transforming growth factor, beta 1 Mus musculus 132-141 28284148-8 2017 Furthermore, UA effectively moderated the histopathological changes, reduced the content of MDA, HYP, TNF-alpha, IL-1beta, IL-6 and TGF-beta1, and increased the level of SOD when combined with BLM in lung tissues of H22-bearing mice, which was believed to be related to the inhibition on the protein level of p-Smad2/3 and enhancement of Smad7 expression. usnic acid 13-15 SMAD family member 7 Mus musculus 338-343 28245124-9 2017 Collectively, usnic acid and analogues are potential lead mTOR inhibitors appropriate for future use to control breast malignancies. usnic acid 14-24 mechanistic target of rapamycin kinase Homo sapiens 58-62 27369375-3 2017 In this study, we investigated the role of oxidative stress and the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells. usnic acid 94-104 NFE2 like bZIP transcription factor 2 Homo sapiens 68-72 27369375-6 2017 Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). usnic acid 32-42 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 27369375-6 2017 Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). usnic acid 32-42 NFE2 like bZIP transcription factor 2 Homo sapiens 95-138 27369375-6 2017 Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). usnic acid 32-42 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 27369375-6 2017 Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). usnic acid 32-42 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 27369375-6 2017 Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). usnic acid 32-42 glutathione-disulfide reductase Homo sapiens 327-348 27369375-6 2017 Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). usnic acid 32-42 glutathione S-transferase kappa 1 Homo sapiens 350-375 27369375-6 2017 Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). usnic acid 32-42 NAD(P)H quinone dehydrogenase 1 Homo sapiens 381-413 27369375-6 2017 Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). usnic acid 32-42 NAD(P)H quinone dehydrogenase 1 Homo sapiens 415-419 27369375-7 2017 Furthermore, knockdown of Nrf2 with shRNA potentiated usnic acid-induced DNA damage and cytotoxicity. usnic acid 54-64 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 27369375-8 2017 Taken together, our results show that usnic acid causes cell cycle dysregulation, DNA damage, and oxidative stress and that the Nrf2 signaling pathway is activated in usnic acid-induced cytotoxicity. usnic acid 167-177 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 27933897-3 2016 Several novel usnic acid derivatives with an enamine moiety have been synthesized and tested as inhibitors of TDP1. usnic acid 14-24 tyrosyl-DNA phosphodiesterase 1 Homo sapiens 110-114 29348773-6 2017 The anti-inflammatory activity of UA and UA-micro was evaluated by subcutaneous air pouch and carrageenan-induced paw edema in rat, with measurement of inflammatory cytokines and MPO levels. usnic acid 34-36 myeloperoxidase Rattus norvegicus 179-182 29348773-10 2017 UA-micro and UA (25 mg/kg) significantly reduced paw volume and decreased MPO levels, whereas only UA-micro (50 mg/kg) reduced significantly IL-1beta, TNF-alpha, and NO levels in inflammatory exudate. usnic acid 0-2 myeloperoxidase Rattus norvegicus 74-77 29348773-10 2017 UA-micro and UA (25 mg/kg) significantly reduced paw volume and decreased MPO levels, whereas only UA-micro (50 mg/kg) reduced significantly IL-1beta, TNF-alpha, and NO levels in inflammatory exudate. usnic acid 13-15 myeloperoxidase Rattus norvegicus 74-77 29348773-10 2017 UA-micro and UA (25 mg/kg) significantly reduced paw volume and decreased MPO levels, whereas only UA-micro (50 mg/kg) reduced significantly IL-1beta, TNF-alpha, and NO levels in inflammatory exudate. usnic acid 13-15 myeloperoxidase Rattus norvegicus 74-77 26751081-7 2016 Also, Rac1 and RhoA activities were decreased by treatment with (+)-usnic acid. usnic acid 64-78 ras homolog family member A Homo sapiens 15-19 25870318-9 2015 Usnic acid increased the expression of calcium release-activated calcium channel protein 1 (CRAM1 or ORAI1) and stromal interaction molecule 1, two key components of store-operated calcium entry (SOCE), which is the major Ca(2+) influx pathway in non-excitable cells, this finding was also confirmed in primary rat hepatocytes. usnic acid 0-10 ORAI calcium release-activated calcium modulator 1 Rattus norvegicus 39-90 26751081-5 2016 Mechanistically, beta-catenin-mediated TOPFLASH activity and KITENIN-mediated AP-1 activity were decreased by (+)-usnic acid treatment in a dose-dependent manner. usnic acid 110-124 catenin beta 1 Homo sapiens 17-29 26751081-5 2016 Mechanistically, beta-catenin-mediated TOPFLASH activity and KITENIN-mediated AP-1 activity were decreased by (+)-usnic acid treatment in a dose-dependent manner. usnic acid 110-124 VANGL planar cell polarity protein 1 Homo sapiens 61-68 26751081-5 2016 Mechanistically, beta-catenin-mediated TOPFLASH activity and KITENIN-mediated AP-1 activity were decreased by (+)-usnic acid treatment in a dose-dependent manner. usnic acid 110-124 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 78-82 26751081-6 2016 The quantitative real-time PCR data showed that (+)-usnic acid decreased the mRNA level of CD44, Cyclin D1 and c-myc, which are the downstream target genes of both beta-catenin/LEF and c-jun/AP-1. usnic acid 48-62 CD44 molecule (Indian blood group) Homo sapiens 91-95 26751081-6 2016 The quantitative real-time PCR data showed that (+)-usnic acid decreased the mRNA level of CD44, Cyclin D1 and c-myc, which are the downstream target genes of both beta-catenin/LEF and c-jun/AP-1. usnic acid 48-62 cyclin D1 Homo sapiens 97-106 26751081-6 2016 The quantitative real-time PCR data showed that (+)-usnic acid decreased the mRNA level of CD44, Cyclin D1 and c-myc, which are the downstream target genes of both beta-catenin/LEF and c-jun/AP-1. usnic acid 48-62 MYC proto-oncogene, bHLH transcription factor Homo sapiens 111-116 26751081-6 2016 The quantitative real-time PCR data showed that (+)-usnic acid decreased the mRNA level of CD44, Cyclin D1 and c-myc, which are the downstream target genes of both beta-catenin/LEF and c-jun/AP-1. usnic acid 48-62 catenin beta 1 Homo sapiens 164-176 26751081-6 2016 The quantitative real-time PCR data showed that (+)-usnic acid decreased the mRNA level of CD44, Cyclin D1 and c-myc, which are the downstream target genes of both beta-catenin/LEF and c-jun/AP-1. usnic acid 48-62 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 185-190 26751081-6 2016 The quantitative real-time PCR data showed that (+)-usnic acid decreased the mRNA level of CD44, Cyclin D1 and c-myc, which are the downstream target genes of both beta-catenin/LEF and c-jun/AP-1. usnic acid 48-62 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 191-195 26751081-7 2016 Also, Rac1 and RhoA activities were decreased by treatment with (+)-usnic acid. usnic acid 64-78 Rac family small GTPase 1 Homo sapiens 6-10 25870318-5 2015 We found that usnic acid causes endoplasmic reticulum (ER) stress demonstrated by the increased expression of typical ER stress markers, including CHOP, ATF-4, p-eIF2alpha, and spliced XBP1. usnic acid 14-24 DNA damage inducible transcript 3 Homo sapiens 147-151 25870318-5 2015 We found that usnic acid causes endoplasmic reticulum (ER) stress demonstrated by the increased expression of typical ER stress markers, including CHOP, ATF-4, p-eIF2alpha, and spliced XBP1. usnic acid 14-24 activating transcription factor 4 Homo sapiens 153-158 25870318-9 2015 Usnic acid increased the expression of calcium release-activated calcium channel protein 1 (CRAM1 or ORAI1) and stromal interaction molecule 1, two key components of store-operated calcium entry (SOCE), which is the major Ca(2+) influx pathway in non-excitable cells, this finding was also confirmed in primary rat hepatocytes. usnic acid 0-10 ORAI calcium release-activated calcium modulator 1 Rattus norvegicus 101-106 25870318-5 2015 We found that usnic acid causes endoplasmic reticulum (ER) stress demonstrated by the increased expression of typical ER stress markers, including CHOP, ATF-4, p-eIF2alpha, and spliced XBP1. usnic acid 14-24 X-box binding protein 1 Homo sapiens 185-189 25870318-9 2015 Usnic acid increased the expression of calcium release-activated calcium channel protein 1 (CRAM1 or ORAI1) and stromal interaction molecule 1, two key components of store-operated calcium entry (SOCE), which is the major Ca(2+) influx pathway in non-excitable cells, this finding was also confirmed in primary rat hepatocytes. usnic acid 0-10 stromal interaction molecule 1 Rattus norvegicus 112-142 25870318-10 2015 Furthermore, knockdown of ORAI1 prevented ER stress and ATP depletion in response to usnic acid. usnic acid 85-95 ORAI calcium release-activated calcium modulator 1 Homo sapiens 26-31 25870318-11 2015 In contrast, overexpression of ORAI1 increased ER stress and ATP depletion caused by usnic acid. usnic acid 85-95 ORAI calcium release-activated calcium modulator 1 Homo sapiens 31-36 25078063-3 2014 Usnic acid caused apoptosis as demonstrated by an increased caspase-3/7 activity and an increased subdiploid nucleus formation. usnic acid 0-10 caspase 3 Homo sapiens 60-69 25078063-4 2014 Usnic acid-induced autophagy as demonstrated by the conversion of LC3B-I to LC3B-II, degradation of P62, and an increased number of puncta. usnic acid 0-10 nucleoporin 62 Homo sapiens 100-103 25078063-5 2014 Inhibition of autophagy by treating cells with autophagy inhibitors (3-methyladenine or chloroquine) or by small interfering RNA against Atg7 aggravated usnic acid-induced apoptosis and decreased cell viability, indicating that autophagy plays a protective role against usnic acid-induced toxicity. usnic acid 153-163 autophagy related 7 Homo sapiens 137-141 25078063-5 2014 Inhibition of autophagy by treating cells with autophagy inhibitors (3-methyladenine or chloroquine) or by small interfering RNA against Atg7 aggravated usnic acid-induced apoptosis and decreased cell viability, indicating that autophagy plays a protective role against usnic acid-induced toxicity. usnic acid 270-280 autophagy related 7 Homo sapiens 137-141 25078063-7 2014 Usnic acid-elicited apoptosis was enhanced and autophagy was decreased when JNK was suppressed by a specific inhibitor. usnic acid 0-10 mitogen-activated protein kinase 8 Homo sapiens 76-79 25068825-5 2014 In the meantime, protein content and the number of inflammatory cells in bronchoalveolar lavage fluid (BALF) significantly decreased, and the levels of MPO, MDA, and H2O2 in lung tissue were markedly suppressed after treatment with usnic acid. usnic acid 232-242 myeloperoxidase Mus musculus 152-155 25068825-8 2014 The results in the present study indicated that usnic acid attenuated the expression of TNF-alpha, IL-6, IL-8 and MIP-2. usnic acid 48-58 tumor necrosis factor Mus musculus 88-97 25068825-8 2014 The results in the present study indicated that usnic acid attenuated the expression of TNF-alpha, IL-6, IL-8 and MIP-2. usnic acid 48-58 interleukin 6 Mus musculus 99-103 25068825-8 2014 The results in the present study indicated that usnic acid attenuated the expression of TNF-alpha, IL-6, IL-8 and MIP-2. usnic acid 48-58 chemokine (C-X-C motif) ligand 15 Mus musculus 105-109 25068825-8 2014 The results in the present study indicated that usnic acid attenuated the expression of TNF-alpha, IL-6, IL-8 and MIP-2. usnic acid 48-58 chemokine (C-X-C motif) ligand 2 Mus musculus 114-119 22669534-0 2012 Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. usnic acid 0-10 kinase insert domain protein receptor Mus musculus 72-78 25268102-0 2014 Usnic acid inhibits ER stress activation through AMPK signaling pathway in rat cardiomyocytes. usnic acid 0-10 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 49-53 25268102-4 2014 Finally, small interfering RNA (siRNA) oligos targeting AMPK subunits were used to determine the roles of AMPK in rat cardiomyocytes treated with UA. usnic acid 146-148 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 106-110 25268102-5 2014 RESULTS: We found that UA treatment significantly reduced ER stress activation and expression of pro-inflammatory cytokines, via an AMPK signaling-dependent manner. usnic acid 23-25 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 132-136 23682781-4 2013 UA treatment (25-100 muM) for 24 and 48 h decreased total cell number by 39-67% (P < 0.01) and 68-89% (P < 0.001), respectively, and enhanced cell death by up to twofold and eightfold (P < 0.001), respectively. usnic acid 0-2 latexin Homo sapiens 21-24 23682781-7 2013 UA decreased the expression of cyclin-dependent kinase (CDK)4, CDK6, and cyclin D1 and increased the expression of CDK inhibitor (CDKI) p21/cip1 protein. usnic acid 0-2 cyclin dependent kinase 4 Homo sapiens 56-61 23682781-7 2013 UA decreased the expression of cyclin-dependent kinase (CDK)4, CDK6, and cyclin D1 and increased the expression of CDK inhibitor (CDKI) p21/cip1 protein. usnic acid 0-2 cyclin dependent kinase 6 Homo sapiens 63-67 23682781-7 2013 UA decreased the expression of cyclin-dependent kinase (CDK)4, CDK6, and cyclin D1 and increased the expression of CDK inhibitor (CDKI) p21/cip1 protein. usnic acid 0-2 cyclin D1 Homo sapiens 73-82 23682781-7 2013 UA decreased the expression of cyclin-dependent kinase (CDK)4, CDK6, and cyclin D1 and increased the expression of CDK inhibitor (CDKI) p21/cip1 protein. usnic acid 0-2 cyclin dependent kinase inhibitor 1A Homo sapiens 136-139 23682781-7 2013 UA decreased the expression of cyclin-dependent kinase (CDK)4, CDK6, and cyclin D1 and increased the expression of CDK inhibitor (CDKI) p21/cip1 protein. usnic acid 0-2 cyclin dependent kinase inhibitor 1A Homo sapiens 140-144 22669534-0 2012 Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. usnic acid 0-10 thymoma viral proto-oncogene 1 Mus musculus 88-91 22669534-0 2012 Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. usnic acid 0-10 mitogen-activated protein kinase 3 Mus musculus 96-102 22669534-10 2012 In addition, UA inhibited Bcap-37 tumor cell proliferation. usnic acid 13-15 prohibitin 2 Mus musculus 26-33 22741606-0 2012 Influence of usnic acid and its derivatives on the activity of mammalian poly(ADP-ribose)polymerase 1 and DNA polymerase beta. usnic acid 13-23 poly(ADP-ribose) polymerase 1 Homo sapiens 73-101 21953288-9 2012 A marked up-regulation of one gene CCL21 associated with inflammation, one gene CCNC associated with proliferation and carcinogenesis and one gene UGT1A4 associated with metabolism as well as DNA damage and repair were observed in the usnic acid-treated cells compared with the vehicle control. usnic acid 235-245 C-C motif chemokine ligand 21 Homo sapiens 35-40 21953288-9 2012 A marked up-regulation of one gene CCL21 associated with inflammation, one gene CCNC associated with proliferation and carcinogenesis and one gene UGT1A4 associated with metabolism as well as DNA damage and repair were observed in the usnic acid-treated cells compared with the vehicle control. usnic acid 235-245 cyclin C Homo sapiens 80-84 21953288-9 2012 A marked up-regulation of one gene CCL21 associated with inflammation, one gene CCNC associated with proliferation and carcinogenesis and one gene UGT1A4 associated with metabolism as well as DNA damage and repair were observed in the usnic acid-treated cells compared with the vehicle control. usnic acid 235-245 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 147-153 21953288-10 2012 Also a marked down-regulation of one gene CSF2 associated with inflammation and two genes (CYP7A1 and CYP2E1) associated with oxidative metabolic stress were observed in the usnic acid-treated cells compared with the control. usnic acid 174-184 colony stimulating factor 2 Homo sapiens 42-46 21953288-10 2012 Also a marked down-regulation of one gene CSF2 associated with inflammation and two genes (CYP7A1 and CYP2E1) associated with oxidative metabolic stress were observed in the usnic acid-treated cells compared with the control. usnic acid 174-184 cytochrome P450 family 7 subfamily A member 1 Homo sapiens 91-97 21953288-10 2012 Also a marked down-regulation of one gene CSF2 associated with inflammation and two genes (CYP7A1 and CYP2E1) associated with oxidative metabolic stress were observed in the usnic acid-treated cells compared with the control. usnic acid 174-184 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 102-108 22741606-0 2012 Influence of usnic acid and its derivatives on the activity of mammalian poly(ADP-ribose)polymerase 1 and DNA polymerase beta. usnic acid 13-23 DNA polymerase beta Homo sapiens 106-125 22741606-1 2012 The influence of a number of usnic acid derivatives on auto(polyADP-ribosyl)ation catalyzed by PARP1 and DNA synthesis catalyzed by DNA polymerase beta was studied. usnic acid 29-39 poly(ADP-ribose) polymerase 1 Homo sapiens 95-100 22741606-2 2012 The derivatives of usnic acid containing aromatic substituents were shown to be moderate inhibitors of PARP1. usnic acid 19-29 poly(ADP-ribose) polymerase 1 Homo sapiens 103-108 19125581-3 2009 A charge-transfer complex was formed in which TNF was sandwiched between the two usnic acid units with pi-pi-stacked aromatic interactions. usnic acid 81-91 tumor necrosis factor Homo sapiens 46-49 22775414-11 2012 Usnic acid showed noncompetitive type of HMGR inhibition and uncompetitive type of ACE inhibition. usnic acid 0-10 angiotensin I converting enzyme Homo sapiens 83-86 22285236-6 2012 Usnic acid and atranorin were capable of inducing a massive loss in the mitochondrial membrane potential, along with caspase-3 activation (only in HT-29 cells) and phosphatidylserine externalization in both tested cell lines. usnic acid 0-10 caspase 3 Homo sapiens 117-126 22285236-8 2012 Based on the detection of protein expression (PARP, p53, Bcl-2/Bcl-xL, Bax, p38, pp38) we found that usnic acid and atranorin are activators of programmed cell death in A2780 and HT-29, probably through the mitochondrial pathway. usnic acid 101-111 collagen type XI alpha 2 chain Homo sapiens 46-50 22285236-8 2012 Based on the detection of protein expression (PARP, p53, Bcl-2/Bcl-xL, Bax, p38, pp38) we found that usnic acid and atranorin are activators of programmed cell death in A2780 and HT-29, probably through the mitochondrial pathway. usnic acid 101-111 tumor protein p53 Homo sapiens 52-55 22285236-8 2012 Based on the detection of protein expression (PARP, p53, Bcl-2/Bcl-xL, Bax, p38, pp38) we found that usnic acid and atranorin are activators of programmed cell death in A2780 and HT-29, probably through the mitochondrial pathway. usnic acid 101-111 BCL2 apoptosis regulator Homo sapiens 57-62 22285236-8 2012 Based on the detection of protein expression (PARP, p53, Bcl-2/Bcl-xL, Bax, p38, pp38) we found that usnic acid and atranorin are activators of programmed cell death in A2780 and HT-29, probably through the mitochondrial pathway. usnic acid 101-111 BCL2 like 1 Homo sapiens 63-69 22285236-8 2012 Based on the detection of protein expression (PARP, p53, Bcl-2/Bcl-xL, Bax, p38, pp38) we found that usnic acid and atranorin are activators of programmed cell death in A2780 and HT-29, probably through the mitochondrial pathway. usnic acid 101-111 BCL2 associated X, apoptosis regulator Homo sapiens 71-74 22285236-8 2012 Based on the detection of protein expression (PARP, p53, Bcl-2/Bcl-xL, Bax, p38, pp38) we found that usnic acid and atranorin are activators of programmed cell death in A2780 and HT-29, probably through the mitochondrial pathway. usnic acid 101-111 mitogen-activated protein kinase 14 Homo sapiens 76-79 19003951-0 2008 Down-regulatory effect of usnic acid on nuclear factor-kappaB-dependent tumor necrosis factor-alpha and inducible nitric oxide synthase expression in lipopolysaccharide-stimulated macrophages RAW 264.7. usnic acid 26-36 tumor necrosis factor Homo sapiens 72-99 19003951-3 2008 The present study examined the effects of UA on the tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophages and the underlying molecular mechanisms. usnic acid 42-44 tumor necrosis factor Homo sapiens 81-90 19003951-4 2008 UA decreased the TNF-alpha level in LPS-stimulated RAW264.7 macrophages in dose-dependent manner, the IC(50) value was 12.8 microM. usnic acid 0-2 tumor necrosis factor Homo sapiens 17-26 19003951-7 2008 Western blot analysis showed that UA attenuated LPS-induced synthesis of iNOS protein and nuclear translocation of NF-kappaB p65 in the macrophages, in parallel. usnic acid 34-36 nitric oxide synthase 2 Homo sapiens 73-77 19003951-7 2008 Western blot analysis showed that UA attenuated LPS-induced synthesis of iNOS protein and nuclear translocation of NF-kappaB p65 in the macrophages, in parallel. usnic acid 34-36 nuclear factor kappa B subunit 1 Homo sapiens 115-124 19003951-7 2008 Western blot analysis showed that UA attenuated LPS-induced synthesis of iNOS protein and nuclear translocation of NF-kappaB p65 in the macrophages, in parallel. usnic acid 34-36 RELA proto-oncogene, NF-kB subunit Homo sapiens 125-128 19003951-8 2008 UA also inhibited LPS-mediated I-kappaBalpha degradation. usnic acid 0-2 NFKB inhibitor alpha Homo sapiens 31-44 19003951-9 2008 Taken together, this suggests that UA has an antiinflammatory effect by inhibiting TNF-alpha and iNOS expression, possibly through suppression of nuclear translocation of NF-kappaB p65 and I-kappaBalpha degradation. usnic acid 35-37 tumor necrosis factor Homo sapiens 83-92 19003951-9 2008 Taken together, this suggests that UA has an antiinflammatory effect by inhibiting TNF-alpha and iNOS expression, possibly through suppression of nuclear translocation of NF-kappaB p65 and I-kappaBalpha degradation. usnic acid 35-37 nitric oxide synthase 2 Homo sapiens 97-101 19003951-9 2008 Taken together, this suggests that UA has an antiinflammatory effect by inhibiting TNF-alpha and iNOS expression, possibly through suppression of nuclear translocation of NF-kappaB p65 and I-kappaBalpha degradation. usnic acid 35-37 nuclear factor kappa B subunit 1 Homo sapiens 171-180 19003951-9 2008 Taken together, this suggests that UA has an antiinflammatory effect by inhibiting TNF-alpha and iNOS expression, possibly through suppression of nuclear translocation of NF-kappaB p65 and I-kappaBalpha degradation. usnic acid 35-37 RELA proto-oncogene, NF-kB subunit Homo sapiens 181-184 19003951-9 2008 Taken together, this suggests that UA has an antiinflammatory effect by inhibiting TNF-alpha and iNOS expression, possibly through suppression of nuclear translocation of NF-kappaB p65 and I-kappaBalpha degradation. usnic acid 35-37 NFKB inhibitor alpha Homo sapiens 189-202 18274956-6 2008 Usnic acid was a relatively weak inhibitor of CYP2D6 and a potent inhibitor of CYP2C19 (the concentration eliciting 50% inhibition (IC(50)) = 9 nM) and CYP2C9 (IC(50) = 94 nM), with less potent inhibition of CYP2C8 (IC(50) = 1.9 microM) and CYP2C18 (IC(50) = 6.3 microM). usnic acid 0-10 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 46-52 18274956-6 2008 Usnic acid was a relatively weak inhibitor of CYP2D6 and a potent inhibitor of CYP2C19 (the concentration eliciting 50% inhibition (IC(50)) = 9 nM) and CYP2C9 (IC(50) = 94 nM), with less potent inhibition of CYP2C8 (IC(50) = 1.9 microM) and CYP2C18 (IC(50) = 6.3 microM). usnic acid 0-10 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 79-86 18274956-6 2008 Usnic acid was a relatively weak inhibitor of CYP2D6 and a potent inhibitor of CYP2C19 (the concentration eliciting 50% inhibition (IC(50)) = 9 nM) and CYP2C9 (IC(50) = 94 nM), with less potent inhibition of CYP2C8 (IC(50) = 1.9 microM) and CYP2C18 (IC(50) = 6.3 microM). usnic acid 0-10 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 152-158 18274956-6 2008 Usnic acid was a relatively weak inhibitor of CYP2D6 and a potent inhibitor of CYP2C19 (the concentration eliciting 50% inhibition (IC(50)) = 9 nM) and CYP2C9 (IC(50) = 94 nM), with less potent inhibition of CYP2C8 (IC(50) = 1.9 microM) and CYP2C18 (IC(50) = 6.3 microM). usnic acid 0-10 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 208-214 18274956-6 2008 Usnic acid was a relatively weak inhibitor of CYP2D6 and a potent inhibitor of CYP2C19 (the concentration eliciting 50% inhibition (IC(50)) = 9 nM) and CYP2C9 (IC(50) = 94 nM), with less potent inhibition of CYP2C8 (IC(50) = 1.9 microM) and CYP2C18 (IC(50) = 6.3 microM). usnic acid 0-10 cytochrome P450 family 2 subfamily C member 18 Homo sapiens 241-248