PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 28944796-0 2017 AuNPs/COFs as a new type of SERS substrate for sensitive recognition of polyaromatic hydrocarbons. polyaromatic hydrocarbons 72-97 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 28-32 25840912-8 2015 These findings indicate that in mice HSP27 and HSP70 play a key role in the induction of cell-mediated immunity to carcinogenic polyaromatic hydrocarbons. polyaromatic hydrocarbons 128-153 heat shock protein 1 Mus musculus 37-42 28801182-2 2017 In our previous paper (Drug Metabolism Parmacokinet31: 363, 2016), a simulation system for ligand interactions of human CYP1A2 was developed using "Template" composed of hexagonal grids focusing on polyaromatic hydrocarbons (PAHs). polyaromatic hydrocarbons 198-223 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 120-126 26618301-9 2016 The antioxidant response genes (Nqo1 and Hmox1) were moderately associated with polyaromatic hydrocarbons (PAHs) and showed a good correlation (r-Pearson of >0.7) with metals linked to vehicle-related emissions (i.e. Cu, Zn and Sb). polyaromatic hydrocarbons 80-105 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 26618301-9 2016 The antioxidant response genes (Nqo1 and Hmox1) were moderately associated with polyaromatic hydrocarbons (PAHs) and showed a good correlation (r-Pearson of >0.7) with metals linked to vehicle-related emissions (i.e. Cu, Zn and Sb). polyaromatic hydrocarbons 80-105 heme oxygenase 1 Homo sapiens 41-46 27819086-4 2016 In this article, we consider two specific cases of molecular distortions - the first one being spontaneous for contorted polyaromatic hydrocarbons (c-PAH) where non-bonded repulsions between the two pairs of syn H-atoms in tribenzopyrene, TBP (1), can enforce either a C2v C2 or C2v Cs distortion. polyaromatic hydrocarbons 121-146 TATA-box binding protein Homo sapiens 239-242 27331086-1 2016 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is the principal regulator of a cell s response to many polyaromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). polyaromatic hydrocarbons 140-165 aryl-hydrocarbon receptor Mus musculus 4-29 27331086-1 2016 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is the principal regulator of a cell s response to many polyaromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). polyaromatic hydrocarbons 140-165 aryl-hydrocarbon receptor Mus musculus 31-34 30090422-0 2016 Effects of multi-component mixtures of polyaromatic hydrocarbons and heavy metal/loid(s) on Nrf2-antioxidant response element (ARE) pathway in ARE reporter-HepG2 cells. polyaromatic hydrocarbons 39-64 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 25840912-8 2015 These findings indicate that in mice HSP27 and HSP70 play a key role in the induction of cell-mediated immunity to carcinogenic polyaromatic hydrocarbons. polyaromatic hydrocarbons 128-153 heat shock protein 1B Mus musculus 47-52 23266674-2 2013 AhR mediates the biochemical and toxic effects of a number of polyaromatic hydrocarbons such as 2,3,7,8,-tetrachloro-dibenzo-p-dioxin (TCDD). polyaromatic hydrocarbons 62-87 aryl hydrocarbon receptor Homo sapiens 0-3 25694611-2 2015 Skin tumors produced by polyaromatic hydrocarbons, such as 7,12-dimethylbenz(a)anthracene (DMBA), often harbor an H-ras point mutation, suggesting that it is a poor target for early immunosurveillance. polyaromatic hydrocarbons 24-49 Harvey rat sarcoma virus oncogene Mus musculus 114-119 23975144-1 2013 Human serum albumin (HSA) has been used as a model for the binding of a number of different ligands, including polyaromatic hydrocarbons, to proteins. polyaromatic hydrocarbons 111-136 albumin Homo sapiens 6-25 22296395-2 2011 The aryl hydrocarbon receptor (AhR) mediates endocrine disruptive activities of polyaromatic hydrocarbons (PAHs) and dioxins, which may compromise ovarian functions of women in polluted environments. polyaromatic hydrocarbons 80-105 aryl hydrocarbon receptor Homo sapiens 4-29 22718620-1 2012 The aryl hydrocarbon receptor (AhR) recognizes a large number of xenobiotics, such as polyaromatic hydrocarbons (PAHs) and dioxins, and it activates several metabolic and detoxification pathways. polyaromatic hydrocarbons 86-111 aryl hydrocarbon receptor Homo sapiens 4-29 22718620-1 2012 The aryl hydrocarbon receptor (AhR) recognizes a large number of xenobiotics, such as polyaromatic hydrocarbons (PAHs) and dioxins, and it activates several metabolic and detoxification pathways. polyaromatic hydrocarbons 86-111 aryl hydrocarbon receptor Homo sapiens 31-34 21332130-0 2011 Enhanced bioavailability of polyaromatic hydrocarbons in the form of mucin complexes. polyaromatic hydrocarbons 28-53 mucin 1, cell surface associated Bos taurus 69-74 22296395-2 2011 The aryl hydrocarbon receptor (AhR) mediates endocrine disruptive activities of polyaromatic hydrocarbons (PAHs) and dioxins, which may compromise ovarian functions of women in polluted environments. polyaromatic hydrocarbons 80-105 aryl hydrocarbon receptor Homo sapiens 31-34 18834169-6 2008 On the other hand, the activity of phospholipase A2 toward DLPC used as a probe to locate benzo[a]pyrene in the monolayers indicates that the polyaromatic hydrocarbons are not accessible to the enzyme. polyaromatic hydrocarbons 142-167 phospholipase A2 group IB Homo sapiens 35-51 20868221-2 2010 One of these intracellular chemosensor molecules is the aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family that is known to mediate the biochemical and toxic effects of dioxins, polyaromatic hydrocarbons and related compounds. polyaromatic hydrocarbons 206-231 aryl hydrocarbon receptor Homo sapiens 56-81 20868221-2 2010 One of these intracellular chemosensor molecules is the aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family that is known to mediate the biochemical and toxic effects of dioxins, polyaromatic hydrocarbons and related compounds. polyaromatic hydrocarbons 206-231 aryl hydrocarbon receptor Homo sapiens 83-86 19364907-1 2009 Microsomal epoxide hydrolase (EPHX1) biotransforms epoxide derivatives of pharmaceuticals, including metabolites of certain antiepileptic medications, such as phenytoin and carbamazepine, and many environmental epoxides, such as those derived from butadiene, benzene, and carcinogenic polyaromatic hydrocarbons. polyaromatic hydrocarbons 285-310 epoxide hydrolase 1 Homo sapiens 0-28 19364907-1 2009 Microsomal epoxide hydrolase (EPHX1) biotransforms epoxide derivatives of pharmaceuticals, including metabolites of certain antiepileptic medications, such as phenytoin and carbamazepine, and many environmental epoxides, such as those derived from butadiene, benzene, and carcinogenic polyaromatic hydrocarbons. polyaromatic hydrocarbons 285-310 epoxide hydrolase 1 Homo sapiens 30-35 16996243-6 2006 CYP1B1 metabolizes both endogenous estrogens and polyaromatic hydrocarbons in ETS to a variety of reactive species and may contribute to the complex effects of ETS on ovarian function. polyaromatic hydrocarbons 49-74 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 17973980-1 2008 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor activated by dioxin and polyaromatic hydrocarbons. polyaromatic hydrocarbons 103-128 aryl hydrocarbon receptor Homo sapiens 4-29 17973980-1 2008 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor activated by dioxin and polyaromatic hydrocarbons. polyaromatic hydrocarbons 103-128 aryl hydrocarbon receptor Homo sapiens 31-34 17711870-1 2007 BACKGROUND: Microsomal epoxide hydrolase (EPHX1) metabolises xenobiotics including polyaromatic hydrocarbons (PAHs). polyaromatic hydrocarbons 83-108 epoxide hydrolase 1 Homo sapiens 12-40 17711870-1 2007 BACKGROUND: Microsomal epoxide hydrolase (EPHX1) metabolises xenobiotics including polyaromatic hydrocarbons (PAHs). polyaromatic hydrocarbons 83-108 epoxide hydrolase 1 Homo sapiens 42-47 17012224-3 2007 Many AHR agonists, like the polyaromatic hydrocarbons and polyhalogenated hydrocarbons are known human carcinogens. polyaromatic hydrocarbons 28-53 aryl hydrocarbon receptor Homo sapiens 5-8 16530937-2 2007 Smoking, including exposure to polyaromatic hydrocarbons like benzo[a]pyrene (BaP), is a major risk factor. polyaromatic hydrocarbons 31-56 prohibitin 2 Homo sapiens 78-81 16891617-1 2006 The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helix-loop-helix transcription factor that binds polyaromatic hydrocarbons (PAH), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and mediates their toxicity. polyaromatic hydrocarbons 113-138 aryl-hydrocarbon receptor Mus musculus 4-29 16891617-1 2006 The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helix-loop-helix transcription factor that binds polyaromatic hydrocarbons (PAH), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and mediates their toxicity. polyaromatic hydrocarbons 113-138 aryl-hydrocarbon receptor Mus musculus 31-34 15296456-1 2004 Conversion of hydrophobic substrates such as polyaromatic hydrocarbons (PAHs) was studied in aqueous-organic media using transformation of pyrene by cytochrome c. polyaromatic hydrocarbons 45-70 cytochrome c, somatic Homo sapiens 149-161 16478829-1 2006 AKR1C2, also referred to as the human bile acid binder and 3alpha-hydroxysteroid dehydrogenase type III, is a multifunctional oxidoreductase able to stereoselectively reduce steroids as well as oxidize or reduce polyaromatic hydrocarbons. polyaromatic hydrocarbons 212-237 aldo-keto reductase family 1 member C2 Homo sapiens 0-6 16307481-2 2005 CYP1A1 is involved in the activation of polyaromatic hydrocarbons. polyaromatic hydrocarbons 40-65 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 12797905-0 2003 Polyaromatic hydrocarbons administered in humans by dermal route increase total IgE. polyaromatic hydrocarbons 0-25 immunoglobulin heavy constant epsilon Homo sapiens 80-83 12972062-1 2003 Aryl hydrocarbons such as dioxins, polychlorinated biphenyls and polyaromatic hydrocarbons bind to the cellular aryl hydrocarbon receptor (AhR) in the initial step of their metabolism. polyaromatic hydrocarbons 65-90 aryl-hydrocarbon receptor Mus musculus 112-137 12972062-1 2003 Aryl hydrocarbons such as dioxins, polychlorinated biphenyls and polyaromatic hydrocarbons bind to the cellular aryl hydrocarbon receptor (AhR) in the initial step of their metabolism. polyaromatic hydrocarbons 65-90 aryl hydrocarbon receptor Homo sapiens 139-142 12797905-1 2003 Inhalation of polyaromatic hydrocarbons (PAHs) extracted from diesel exhaust particles (DEP) enhances local (nasal) production of IgE in humans. polyaromatic hydrocarbons 14-39 immunoglobulin heavy constant epsilon Homo sapiens 130-133 11737050-6 2001 IL-10 was further evaluated using benzo[a]pyrene and [alpha]naphthoflavone as a surrogate for the polyaromatic hydrocarbons (PAHs) adsorbed to DEP. polyaromatic hydrocarbons 98-123 interleukin 10 Homo sapiens 0-5 12014952-6 2002 The NK-1 receptor system (represented by a total of 65 antagonist molecules) converges at a cross-validated r2 of 0.870 and a predictive r2 of 0.837; the corresponding values for the Ah receptor system (represented by a total of 131 dibenzodioxins, dibenzofurans, biphenyls, and polyaromatic hydrocarbons) are 0.838 and 0.832, respectively. polyaromatic hydrocarbons 279-304 tachykinin receptor 1 Homo sapiens 4-17 12028803-6 2002 Moreover, HO-1 expression was positively correlated to the higher organic carbon (OC) and polyaromatic hydrocarbons (PAHs) content of fine versus coarse PM, as well as the rise in PAH content that occurs in coarse PM during the winter months. polyaromatic hydrocarbons 90-115 heme oxygenase 1 Homo sapiens 10-14 11565100-3 2001 We found that polyaromatic hydrocarbons was detectable at ppt levels, the estrogenic compounds diethyl phthalate and octylphenol at high ppt levels, steroid hormones at ppb levels, hydrophobic pesticides at low ppb levels, whereas hydrophilic pesticides and bisphenol A were not detectable at all. polyaromatic hydrocarbons 14-39 tachykinin precursor 1 Homo sapiens 58-61 11565100-3 2001 We found that polyaromatic hydrocarbons was detectable at ppt levels, the estrogenic compounds diethyl phthalate and octylphenol at high ppt levels, steroid hormones at ppb levels, hydrophobic pesticides at low ppb levels, whereas hydrophilic pesticides and bisphenol A were not detectable at all. polyaromatic hydrocarbons 14-39 tachykinin precursor 1 Homo sapiens 137-140 10489413-1 1999 : Transcription of the CYP1A1 genes in mammals and fish is stimulated by polyaromatic hydrocarbons. polyaromatic hydrocarbons 73-98 cytochrome P450 1A1 Oryzias latipes 23-29 10488687-8 1999 These are potentially very important findings in light of the role of CYP1A1/1A2 and CYP1B1 in activation of polyaromatic hydrocarbons, heterocyclic amines and nitroaromatic hydrocarbons to genotoxic metabolites, and the health consequences of these metabolites on humans, as consumers of goat milk and meat. polyaromatic hydrocarbons 109-134 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 10488687-8 1999 These are potentially very important findings in light of the role of CYP1A1/1A2 and CYP1B1 in activation of polyaromatic hydrocarbons, heterocyclic amines and nitroaromatic hydrocarbons to genotoxic metabolites, and the health consequences of these metabolites on humans, as consumers of goat milk and meat. polyaromatic hydrocarbons 109-134 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 85-91 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. polyaromatic hydrocarbons 152-177 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. polyaromatic hydrocarbons 152-177 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 42-48 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. polyaromatic hydrocarbons 152-177 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 53-59 10960677-2 2000 Diesel particles and phenanthrene, one of their constituent polyaromatic hydrocarbons, were shown to enhance total allergic antibody (IgE) production, enhance allergen-specific IgE in the presence of allergen, and induce sensitization to a neoantigen. polyaromatic hydrocarbons 60-85 immunoglobulin heavy constant epsilon Homo sapiens 134-137 10960677-2 2000 Diesel particles and phenanthrene, one of their constituent polyaromatic hydrocarbons, were shown to enhance total allergic antibody (IgE) production, enhance allergen-specific IgE in the presence of allergen, and induce sensitization to a neoantigen. polyaromatic hydrocarbons 60-85 immunoglobulin heavy constant epsilon Homo sapiens 177-180 7563171-1 1995 BACKGROUND: Glutathione S-transferase M1 (GSTM1) is active in the detoxication of a number of carcinogens, including polyaromatic hydrocarbons, such as those present in cigarette smoke. polyaromatic hydrocarbons 117-142 glutathione S-transferase mu 1 Homo sapiens 12-40 9525271-1 1998 Microsomal epoxide hydrolase (mEH) catalyses the hydrolysis of xenobiotic epoxides, including various epoxide derivatives of the procarcinogenic polyaromatic hydrocarbons. polyaromatic hydrocarbons 145-170 epoxide hydrolase 1 Homo sapiens 0-28 9525271-1 1998 Microsomal epoxide hydrolase (mEH) catalyses the hydrolysis of xenobiotic epoxides, including various epoxide derivatives of the procarcinogenic polyaromatic hydrocarbons. polyaromatic hydrocarbons 145-170 epoxide hydrolase 1, microsomal Mus musculus 30-33 9208060-2 1997 Studies were undertaken to examine whether extracts of polyaromatic hydrocarbons (PAH) from diesel exhaust particles (DEP) (PAH-DEP) acted as mucosal adjuvants to help initiate or enhance immunoglobulin E (IgE) production in response to common inhaled allergens. polyaromatic hydrocarbons 55-80 immunoglobulin heavy constant epsilon Homo sapiens 206-209 21619347-10 1996 A mixture of polyaromatic hydrocarbons is separated on a 6.9% T, 5.8% C, and 5.5% S poly(AMPS-co-IPAAm) column. polyaromatic hydrocarbons 13-38 adenylosuccinate lyase Homo sapiens 89-93 10224318-2 1999 CYP1A2 is induced by and metabolizes polyaromatic hydrocarbons (PAH) and aromatic amines and could modify effects of exposure to ambient air pollution. polyaromatic hydrocarbons 37-62 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 9512490-1 1998 The transcriptional induction of the cytochrome P-450 1A1 (CYP1A1) gene by xenobiotics such as polyaromatic hydrocarbons is dependent on their interaction with the aryl hydrocarbon receptor. polyaromatic hydrocarbons 95-120 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 37-57 9512490-1 1998 The transcriptional induction of the cytochrome P-450 1A1 (CYP1A1) gene by xenobiotics such as polyaromatic hydrocarbons is dependent on their interaction with the aryl hydrocarbon receptor. polyaromatic hydrocarbons 95-120 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 59-65 9512490-1 1998 The transcriptional induction of the cytochrome P-450 1A1 (CYP1A1) gene by xenobiotics such as polyaromatic hydrocarbons is dependent on their interaction with the aryl hydrocarbon receptor. polyaromatic hydrocarbons 95-120 aryl hydrocarbon receptor Rattus norvegicus 164-189 9485019-3 1998 The cytochrome P450 1A1 (CYP1A1) gene codes for an enzyme that contributes to aryl hydrocarbon hydroxylase activity, which is involved in the metabolism of polyaromatic hydrocarbons. polyaromatic hydrocarbons 156-181 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-23 9485019-3 1998 The cytochrome P450 1A1 (CYP1A1) gene codes for an enzyme that contributes to aryl hydrocarbon hydroxylase activity, which is involved in the metabolism of polyaromatic hydrocarbons. polyaromatic hydrocarbons 156-181 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 9485019-3 1998 The cytochrome P450 1A1 (CYP1A1) gene codes for an enzyme that contributes to aryl hydrocarbon hydroxylase activity, which is involved in the metabolism of polyaromatic hydrocarbons. polyaromatic hydrocarbons 156-181 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-106 7563171-1 1995 BACKGROUND: Glutathione S-transferase M1 (GSTM1) is active in the detoxication of a number of carcinogens, including polyaromatic hydrocarbons, such as those present in cigarette smoke. polyaromatic hydrocarbons 117-142 glutathione S-transferase mu 1 Homo sapiens 42-47 35559685-3 2022 B2 and B3 with larger windows have been used to encapsulate polyaromatic hydrocarbons. polyaromatic hydrocarbons 60-85 immunoglobulin kappa variable 5-2 Homo sapiens 0-9 8319640-0 1993 Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons. polyaromatic hydrocarbons 88-113 phenylalanine hydroxylase Homo sapiens 15-18 8232704-2 1993 A potential mechanism of protection is based on the "induction" of cytochrome P-450 enzymes by polyaromatic hydrocarbons in tobacco smoke. polyaromatic hydrocarbons 95-120 uncharacterized protein LOC107819388 Nicotiana tabacum 67-83 33774063-2 2021 CYP1A1 and CYP1B1 are associated with enhanced carcinogenesis when chronically exposed to certain polyaromatic hydrocarbons, and their inhibition may lead to chemoprevention. polyaromatic hydrocarbons 98-123 cytochrome P450, family 1, subfamily A Danio rerio 0-6 33774063-2 2021 CYP1A1 and CYP1B1 are associated with enhanced carcinogenesis when chronically exposed to certain polyaromatic hydrocarbons, and their inhibition may lead to chemoprevention. polyaromatic hydrocarbons 98-123 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 11-17 34324209-7 2021 The C18 monolithic column constituted a novel nonpolar sorbent for reversed-phase capillary electrochromatography for nonpolar solutes, e.g., alkylbenzenes, alkylphenyl ketones and polyaromatic hydrocarbons, and slightly polar compounds including phenol and chlorophenols. polyaromatic hydrocarbons 181-206 Bardet-Biedl syndrome 9 Homo sapiens 4-7 13932567-0 1963 [Extent of pollution by polyaromatic hydrocarbons of the 3-benzo, 4-pyrene type in the North Sea and glacial Arctic Ocean]. polyaromatic hydrocarbons 24-49 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 93-96 33129239-3 2021 The main purpose of this study was to examine the link of oxidative and genotoxic DNA damage with DNA repair OGG1 gene polymorphism, in charcoal workers exposed to polyaromatic hydrocarbons. polyaromatic hydrocarbons 164-189 8-oxoguanine DNA glycosylase Homo sapiens 109-113 30055502-4 2019 Chemically, strengthening the previous hypothesis, the collected particles were mainly carbonaceous (68%-93%) with the maximum budget of the polyaromatic hydrocarbons being recorded near the surface (1st/5th floor: 1.84, 1.07, 1.15 for PM10, PM2.5 and PM1, respectively). polyaromatic hydrocarbons 141-166 transmembrane protein 11 Homo sapiens 236-239 30950278-3 2019 CYP1A1, one of the three isoforms of the CYP1 family, is widely believed to play an important role in the metabolism and activation of numerous procarcinogens, e.g., polyaromatic hydrocarbons (PAHs) or aromatic amines. polyaromatic hydrocarbons 166-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6