PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15388232-5	2004	Dityrosine crosslink formation was obtained in Cu,Zn-SOD/H2O2-mediated NF-L aggregates.	dityrosine	0-10	superoxide dismutase 1	Homo sapiens	53-56
15388232-5	2004	Dityrosine crosslink formation was obtained in Cu,Zn-SOD/H2O2-mediated NF-L aggregates.	dityrosine	0-10	neurofilament light chain	Homo sapiens	71-75
14717612-0	2004	Copper mediates dityrosine cross-linking of Alzheimer"s amyloid-beta.	dityrosine	16-26	amyloid beta precursor protein	Homo sapiens	56-68
15033422-4	2004	After the exposure to ROS, alpha-synuclein aggregates were formed in the cytoplasm of these cells, and these were immunopositive for ubiquitin, nitrotyrosine and dityrosine, and positive for thioflavin S staining.	dityrosine	162-172	synuclein alpha	Homo sapiens	27-42
14717612-16	2004	Using ESI-MS and a dityrosine specific antibody, we confirmed that Cu(II) (at concentrations lower than that associated with amyloid plaques) induces the generation of dityrosine-cross-linked, SDS-resistant oligomers of human, but not rat, Abeta peptides.	dityrosine	168-178	amyloid beta precursor protein	Rattus norvegicus	240-245
14536032-4	2003	Dityrosine crosslink formation was obtained in copper-mediated NF-L aggregates.	dityrosine	0-10	neurofilament light chain	Homo sapiens	63-67
14661087-6	2003	Calmodulin, which contains a single pair of tyrosyl residues, undergoes both photoactivated and enzyme-catalyzed dityrosine formation.	dityrosine	113-123	calmodulin 1	Homo sapiens	0-10
14661087-7	2003	Polarization measurements, employing the intrinsic fluorescence of dityrosine, and catalytic activity determinations show how different patterns of inter- and intramolecular cross-linking affect the interactions of calmodulin with Ca(2+) and enzymes.	dityrosine	67-77	calmodulin 1	Homo sapiens	215-225
14592461-2	2003	The sequence of FGF-1 amino acid modifications induced by increasing concentrations of ONOO(-) was from cysteine oxidation to dityrosine formation, and to tyrosine/tryptophan nitration.	dityrosine	126-136	fibroblast growth factor 1	Homo sapiens	16-21
14527693-4	2003	In the case of LPP3, a dityrosine motif present in the second cytoplasmic portion was identified as basolateral targeting signal.	dityrosine	23-33	phospholipid phosphatase 3	Homo sapiens	15-19
12693947-6	2003	Spectroscopic analysis revealed the formation of dityrosines as the covalent cross-linker between PBR monomers.	dityrosine	49-60	translocator protein	Homo sapiens	98-101
12857790-2	2003	Previous studies have shown that exposure to oxidative and nitrative species stabilizes alpha-synuclein filaments in vitro, and this stabilization may be due to dityrosine cross-linking.	dityrosine	161-171	synuclein alpha	Homo sapiens	88-103
12824502-4	2003	However, unlike ubiquitin and all other ubiquitin-like modifiers, UBL5 and its yeast ortholog HUB1 both contain a C-terminal di-tyrosine motif followed by a single variable residue instead of the characteristic di-glycine found in all other ubiquitin-like modifiers.	dityrosine	125-136	ubiquitin like 5	Homo sapiens	66-70
12824502-4	2003	However, unlike ubiquitin and all other ubiquitin-like modifiers, UBL5 and its yeast ortholog HUB1 both contain a C-terminal di-tyrosine motif followed by a single variable residue instead of the characteristic di-glycine found in all other ubiquitin-like modifiers.	dityrosine	125-136	ubiquitin-like protein HUB1	Saccharomyces cerevisiae S288C	94-98
12824502-7	2003	The signature C-terminal di-tyrosine residues in UBL5 are involved in the final beta sheet of the protein.	dityrosine	25-36	ubiquitin like 5	Homo sapiens	49-53
12846977-1	2003	Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein (alpha-syn) that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.	dityrosine	159-169	synuclein alpha	Homo sapiens	64-79
12846977-1	2003	Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein (alpha-syn) that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.	dityrosine	159-169	synuclein alpha	Homo sapiens	64-73
12834295-2	2003	The formation of dityrosine from the MPO/H2O2/L-tyrosine system was used as an indicator of the MPO activity.	dityrosine	17-27	myeloperoxidase	Homo sapiens	37-40
12834295-2	2003	The formation of dityrosine from the MPO/H2O2/L-tyrosine system was used as an indicator of the MPO activity.	dityrosine	17-27	myeloperoxidase	Homo sapiens	96-99
12531248-6	2003	Oxidation of lipids was analyzed by formation of conjugated diene and malondialdehyde; and oxidation of Apo-B protein was analyzed by development of bityrosine fluorescence and covalently cross-linked protein.	dityrosine	149-159	apolipoprotein B	Homo sapiens	104-109
12132593-6	2002	All three compounds also inhibited the formation of dityrosine in peroxyl radicals-treated CP.	dityrosine	52-62	ceruloplasmin	Homo sapiens	91-93
12534296-2	2003	We found that the critical rate-limiting step in nucleation of alpha-synuclein fibrils under physiological conditions is the oxidative formation and accumulation of a dimeric, dityrosine cross-linked prenucleus.	dityrosine	176-186	synuclein alpha	Homo sapiens	63-78
12126792-0	2002	Tyrosyl radical production by myeloperoxidase: a phagocyte pathway for lipid peroxidation and dityrosine cross-linking of proteins.	dityrosine	94-104	myeloperoxidase	Homo sapiens	30-45
12126792-4	2002	Protein-bound tyrosyl residues exposed to myeloperoxidase, H(2)O(2), and L-tyrosine were also oxidized to o,o"-dityrosine.	dityrosine	106-121	myeloperoxidase	Homo sapiens	42-57
12214861-2	2002	The oligomerization of bovine Tg are intermolecular reactions that occur through oxidative processes, such as disulfide and dityrosine formation, as well as isopeptide formation; disulfide formation is primarily responsible for Tg oligomerization.	dityrosine	124-134	thyroglobulin	Bos taurus	30-32
11279068-7	2001	These results support the concept that, in the presence of heme peroxidases in vivo, TGF-beta1-induced H2O2 production by fibroblasts may mediate oxidative dityrosine-dependent cross-linking of ECM protein(s).	dityrosine	156-166	transforming growth factor beta 1	Homo sapiens	85-94
12189015-4	2002	In comparison with native molecule, peroxynitrite-treated fibrinogen subjected to SDS-PAGE under reducing conditions revealed not only three bands corresponding to Aalpha, Bbeta and gamma chains, but the existence of additional high molecular bands probably due to the formation of dityrosine crosslinking between fibrinogen subunits.	dityrosine	282-292	fibrinogen beta chain	Homo sapiens	58-68
11070083-6	2000	Although homozygous tep1 mutants initiate the meiotic program and form spores with wild-type kinetics, analysis of the spores produced in tep1 mutants indicates a specific defect in the trafficking or deposition of dityrosine, a major component of yeast spore walls, to the surface.	dityrosine	215-225	putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase	Saccharomyces cerevisiae S288C	138-142
11328670-11	2001	We have determined that peroxynitrite (ONOO- ) is the only known biological oxidant competent to inactivate enzymatic activity, to nitrate critical tyrosine residues, and to induce dityrosine formation in MnSOD.	dityrosine	181-191	superoxide dismutase 2	Homo sapiens	205-210
11279068-3	2001	To determine whether tyrosine residues in fibroblast-derived extracellular matrix (ECM) proteins may be targets of H2O2-mediated dityrosine-dependent cross-linking reactions in response to TGF-beta1, we utilized fluorophore-labeled tyramide, a structurally related phenolic compound that forms dimers with tyrosine, as a probe to detect such reactions under dynamic cell culture conditions.	dityrosine	129-139	transforming growth factor beta 1	Homo sapiens	189-198
11279068-5	2001	This reaction required the presence of a heme peroxidase and was inhibited by catalase or diphenyliodonium (a flavoenzyme inhibitor), similar to the effect on TGF-beta1-induced dityrosine formation.	dityrosine	177-187	transforming growth factor beta 1	Homo sapiens	159-168
11101314-2	2000	They include the monomers and dimers of DT-cross-linked calmodulin and the dimers of bovine pancreatic ribonuclease A and bovine eye lens gammaB-Crystallin.	dityrosine	40-42	calmodulin	Bos taurus	56-66
11101314-6	2000	In contrast, the intramolecularly DT-linked monomeric protein that we studied (DT monomer of calmodulin) is seen to have suffered greater changes in its conformation and stability.	dityrosine	34-36	calmodulin	Bos taurus	93-103
10747881-5	2000	Here we show that exposure of human recombinant alpha-synuclein to nitrating agents (peroxynitrite/CO(2) or myeloperoxidase/H(2)O(2)/nitrite) induces formation of nitrated alpha-synuclein oligomers that are highly stabilized due to covalent cross-linking via the oxidation of tyrosine to form o,o"-dityrosine.	dityrosine	293-308	synuclein alpha	Homo sapiens	48-63
10944432-4	2000	The others (G6 and 1C3 clones) recognized both the di-HP and dityrosine conjugates.	dityrosine	61-71	chloride intracellular channel 1	Mus musculus	12-22
10747881-0	2000	Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers.	dityrosine	0-10	synuclein alpha	Homo sapiens	54-70
10995295-1	2000	The reaction between lactoperoxidase (LPO) and H(2)O(2) in the presence of bovine serum albumin (BSA), beta-lactoglobulin, or casein was investigated for the formation of protein radicals by freeze-quench electron spin resonance (ESR) and by the formation of the protein oxidation product, dityrosine.	dityrosine	290-300	lactoperoxidase	Homo sapiens	21-36
10995295-5	2000	The formation of dityrosine could be detected in reaction mixtures containing LPO and H(2)O(2) after 1 and 10 min of incubation at 25 degrees C both in the absence and in the presence of BSA, beta-lactoglobulin, or casein.	dityrosine	17-27	lactoperoxidase	Homo sapiens	78-81
10995295-9	2000	The role of LPO activity in the formation of ESR detectable radical species and dityrosine in milk was further verified in ultrahigh temperature (UHT) milk with no endogenous enzyme activity, as the formation of ESR detectable radical species and dityrosine took place in UHT milk only upon the addition of both H(2)O(2) and exogenous LPO.	dityrosine	80-90	lactoperoxidase	Homo sapiens	12-15
10995295-9	2000	The role of LPO activity in the formation of ESR detectable radical species and dityrosine in milk was further verified in ultrahigh temperature (UHT) milk with no endogenous enzyme activity, as the formation of ESR detectable radical species and dityrosine took place in UHT milk only upon the addition of both H(2)O(2) and exogenous LPO.	dityrosine	247-257	lactoperoxidase	Homo sapiens	12-15
10747881-5	2000	Here we show that exposure of human recombinant alpha-synuclein to nitrating agents (peroxynitrite/CO(2) or myeloperoxidase/H(2)O(2)/nitrite) induces formation of nitrated alpha-synuclein oligomers that are highly stabilized due to covalent cross-linking via the oxidation of tyrosine to form o,o"-dityrosine.	dityrosine	293-308	myeloperoxidase	Homo sapiens	108-123
10747881-5	2000	Here we show that exposure of human recombinant alpha-synuclein to nitrating agents (peroxynitrite/CO(2) or myeloperoxidase/H(2)O(2)/nitrite) induces formation of nitrated alpha-synuclein oligomers that are highly stabilized due to covalent cross-linking via the oxidation of tyrosine to form o,o"-dityrosine.	dityrosine	293-308	synuclein alpha	Homo sapiens	172-187
10585414-5	1999	Proteolytic digestion and mass spectrometric analysis indicates that the dimer is held together by a dityrosine link between Tyr-289 in each of two LPO molecules.	dityrosine	101-111	lactoperoxidase	Homo sapiens	148-151
10334867-6	1999	Collectively, these results suggest that complete inactivation of MnSOD by ONOO- can occur independent of the active site tyrosine residue and includes not only nitration of critical tyrosine residues but also tyrosine oxidation and subsequent formation of dityrosine.	dityrosine	257-267	superoxide dismutase 2	Homo sapiens	66-71
10574926-8	1999	Under identical conditions, tyrosyl radical, produced by the heme protein myeloperoxidase, selectively increased levels of o,o"-dityrosine, whereas peroxynitrite increased levels of 3-nitrotyrosine and, to a lesser extent, of ortho-tyrosine.	dityrosine	123-138	myeloperoxidase	Mus musculus	74-89
10383389-4	1999	A high degree of apolipoprotein B100 modification results from covalent association of hemoglobin with LDL involving dityrosine formation but not due to the malonaldehyde epitope formation.	dityrosine	117-127	apolipoprotein B	Homo sapiens	17-36
10334867-2	1999	Furthermore, we demonstrated that peroxynitrite (ONOO-) is the only known biological oxidant competent to inactivate enzymatic activity, nitrate critical tyrosine residues, and induce dityrosine formation in MnSOD.	dityrosine	184-194	superoxide dismutase 2	Homo sapiens	208-213
10211406-5	1999	Further experiments performed by reverse-phase high performance liquid chromatography (RP-HPLC), and monitored by fluorescence detection, showed that the dimeric A beta (1-42) forms induced by the peroxidase reaction are the outcomes of dityrosine bridge formation.	dityrosine	237-247	amyloid beta precursor protein	Homo sapiens	162-168
9622489-1	1998	The role of dityrosine as a fluorescent crossbridge between adjacent calmodulin molecules within the high molecular mass polymers that are generated by Arthromyces peroxidase-catalyzed cross-linking [Malencik, D. A., and Anderson, S. R. (1996) Biochemistry 35, 4375] has been examined in frequency domain fluorescence anisotropy studies.	dityrosine	12-22	calmodulin 1	Homo sapiens	69-79
9822654-5	1998	Covalent EGFR dimerization by ONOO- probably involved intermolecular dityrosine cross-linking and was enhanced after receptor activation with epidermal growth factor.	dityrosine	69-79	epidermal growth factor receptor	Homo sapiens	9-13
7947745-11	1994	The average pKa of the dityrosine cross-link in the dimeric calmodulin is 8.5-8.6 (+/- Ca2+).	dityrosine	23-33	calmodulin	Bos taurus	60-70
8605186-0	1996	Dityrosine formation in calmodulin: cross-linking and polymerization catalyzed by Arthromyces peroxidase.	dityrosine	0-10	calmodulin	Bos taurus	24-34
8605186-1	1996	We employ bovine brain calmodulin, a protein that is subject to photoactivated dityrosine formation [Malencik, D. A., & Anderson, S. R. (1987) Biochemistry 26, 695; (1994) Biochemistry 33, 13363], as a model for the development of an efficient enzyme-catalyzed protein cross-linking technique.	dityrosine	79-89	calmodulin	Bos taurus	23-33
8605186-3	1996	Arthromyces peroxidase is the only common peroxidase able to catalyze significant dityrosine production in calmodulin, through a reaction that is largely intermolecular.	dityrosine	82-92	calmodulin	Bos taurus	107-117
8605186-4	1996	Gel filtration yields fractions (accounting for approximately 40% of the initial calmodulin) that represent differing mobility ranges in NaDodSO4 polyacrylamide gel electrophoresis and contain close to the maximum possible amounts of dityrosine.	dityrosine	234-244	calmodulin	Bos taurus	81-91
8605186-9	1996	The ability to prepare soluble calmodulin polymers that retain a substantial degree of biological activity and exhibit the intense visible fluorescence of dityrosine illustrates the potential usefulness of Arthromyces peroxidase in the zero-length cross-linking of proteins.	dityrosine	155-165	calmodulin	Bos taurus	31-41
7696984-5	1994	The simultaneous formation of protein aggregates and bityrosines was interpreted as the involvement of intermolecular bityrosines in the hemin induced crosslinking of Apo B.	dityrosine	53-64	apolipoprotein B	Homo sapiens	167-172
7696984-5	1994	The simultaneous formation of protein aggregates and bityrosines was interpreted as the involvement of intermolecular bityrosines in the hemin induced crosslinking of Apo B.	dityrosine	118-129	apolipoprotein B	Homo sapiens	167-172
7947745-0	1994	Dityrosine formation in calmodulin: conditions for intermolecular cross-linking.	dityrosine	0-10	calmodulin	Bos taurus	24-34
7947745-1	1994	The pattern and extent of photoactivated dityrosine formation in bovine brain calmodulin are strongly affected by the presence of superoxide dismutase during UV irradiation.	dityrosine	41-51	calmodulin	Bos taurus	78-88
7947745-2	1994	The addition of the enzyme to Ca(2+)-containing solutions of calmodulin results in an altered distribution of the dityrosine-containing photoproducts, from a predominance of cross-linked monomer to a mixture of products with inter- and intramolecular cross-linking.	dityrosine	114-124	calmodulin	Bos taurus	61-71
9528688-11	1998	Extension of the model study to irradiated BSA and RNase A also showed DT as the major oxidation product of Tyr under the experimental conditions.	dityrosine	71-73	ribonuclease A family member 1, pancreatic	Homo sapiens	51-58
9446787-2	1998	Here we show that i-Tg, multimerized through formation of disulfide and dityrosine bonds, has a higher iodine content than soluble Tg and no thyroid hormones.	dityrosine	72-82	thyroglobulin	Homo sapiens	20-22
9048907-2	1997	A recombinant fragment of CUT-2, produced in E. coli, can be cross-linked in vitro by horse radish peroxidase via dityrosine formation to give large molecular species [1].	dityrosine	114-124	Cuticlin 2	Caenorhabditis elegans	26-31
8981031-5	1997	When human albumin was exposed to the MPO-H2O2 system, BT was detected after hydrolysis of the protein in the mixture.	dityrosine	55-57	myeloperoxidase	Homo sapiens	38-41
8981031-6	1997	Judging from the chemiluminescence spectra of activated PMNs and the MPO-catalyzed tyrosine oxidation, at least two excited species in triplet states-one for tyrosine and another for BT-would be generated in these systems.	dityrosine	183-185	myeloperoxidase	Homo sapiens	69-72
8702710-0	1996	Human phagocytes employ the myeloperoxidase-hydrogen peroxide system to synthesize dityrosine, trityrosine, pulcherosine, and isodityrosine by a tyrosyl radical-dependent pathway.	dityrosine	83-93	myeloperoxidase	Homo sapiens	28-43
8702710-2	1996	Active myeloperoxidase is a component of human atherosclerotic lesions, and atherosclerotic tissue exhibits selective enrichment of protein dityrosine cross-links, a well characterized product of myeloperoxidase.	dityrosine	140-150	myeloperoxidase	Homo sapiens	7-22
8702710-2	1996	Active myeloperoxidase is a component of human atherosclerotic lesions, and atherosclerotic tissue exhibits selective enrichment of protein dityrosine cross-links, a well characterized product of myeloperoxidase.	dityrosine	140-150	myeloperoxidase	Homo sapiens	196-211
7876345-1	1994	Ovoperoxidase is a cortical granule-derived enzyme that hardens the sea urchin fertilization envelope by catalyzing the formation of dityrosine residues.	dityrosine	133-143	ovoperoxidase	Strongylocentrotus purpuratus	0-13
8037736-0	1994	Presence of dityrosine bridges in thyroglobulin and their relationship with iodination.	dityrosine	12-22	thyroglobulin	Bos taurus	34-47
8037736-3	1994	In this study, we show the presence of 3-3" dityrosine bridges in the molecule of bovine thyroglobulin by NMR and fluorescence studies.	dityrosine	44-54	thyroglobulin	Bos taurus	89-102
8183942-6	1994	DIT2, which is a member of the cytochrome P450 superfamily, is responsible for the dimerization reaction leading to the dityrosine-containing precursors.	dityrosine	120-130	putative cytochrome P450	Saccharomyces cerevisiae S288C	0-4
7935621-0	1994	The role of dityrosine formation in the crosslinking of CUT-2, the product of a second cuticlin gene of Caenorhabditis elegans.	dityrosine	12-22	Cuticlin 2	Caenorhabditis elegans	56-61
7935621-11	1994	Recombinant, soluble CUT-2 is shown to be an excellent substrate for an in vitro cross-linking reaction, catalysed by horseradish peroxidase in the presence of H2O2, which results in the formation of insoluble, high-molecular weight CUT-2 and of dityrosine.	dityrosine	246-256	Cuticlin 2	Caenorhabditis elegans	21-26
8341680-9	1993	We have recently found that myeloperoxidase, a heme protein secreted by activated phagocytes, can also convert L-tyrosine to o,o"-dityrosine.	dityrosine	125-140	myeloperoxidase	Homo sapiens	28-43
8390491-3	1993	Protein-bound tyrosyl residues exposed to myeloperoxidase, H2O2, and L-tyrosine were oxidized to o,o"-dityrosine, a stable product of the tyrosyl radical.	dityrosine	97-112	myeloperoxidase	Homo sapiens	42-57
8390491-8	1993	The requirement for free L-tyrosine and H2O2 for dityrosine formation and the inhibition by heme poisons support the hypothesis that myeloperoxidase catalyzes the cross-linking of proteins by a peroxidative mechanism involving tyrosyl radical.	dityrosine	49-59	myeloperoxidase	Homo sapiens	133-148
8390491-10	1993	We speculate that protein dityrosine cross-linking by myeloperoxidase may play a role in bacterial killing or injuring normal tissue.	dityrosine	26-36	myeloperoxidase	Homo sapiens	54-69
8390491-11	1993	The intense fluorescence and stability of biphenolic compounds may allow dityrosine to act as a marker for proteins oxidatively damaged by myeloperoxidase in phagocyte-rich inflammatory lesions.	dityrosine	73-83	myeloperoxidase	Homo sapiens	139-154
35456059-5	2022	It is accompanied by protein modifications measured as 4-HNE-protein adducts, carbonyl groups, dityrosine increase, and tryptophan level decrease, which promote structural and functional modification of the following transcription factors: Nrf2 and NFkB inhibitors.	dityrosine	95-105	NFE2 like bZIP transcription factor 2	Homo sapiens	240-244
8349141-3	1993	The chromatograms recorded at the dityrosine maximum wavelength (lambda em 400 nm and lambda ex 325 nm) showed the formation of new dimeric peptides which contained two [Met]-enkephalin-derivatives linked by a dityrosyl group.	dityrosine	34-44	proopiomelanocortin	Homo sapiens	170-185
1512290-11	1992	TG in isolated globules was highly iodinated (approximately 55 iodine atoms per 12-S TG subunit) suggesting that the covalent nondisulfide cross-linking occurs in part during the iodination of TG and that this process involves the formation of intermolecular dityrosine bridges.	dityrosine	259-269	thyroglobulin	Bos taurus	0-2
1645541-3	1991	Sulfite plus Co(II) induced bityrosine production, Trp loss and a new Trp-derived fluorescence.	dityrosine	28-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
1846732-4	1991	When 1.14 microM fibronectin was exposed to 50-400 microM HOCl or 50-400 microM H2O2 plus myeloperoxidase and Cl-, there was progressive loss of tryptophan fluorescence and cysteines, and an increase in bityrosine fluorescence and carbonyl content.	dityrosine	203-213	fibronectin 1	Homo sapiens	17-28
1846732-4	1991	When 1.14 microM fibronectin was exposed to 50-400 microM HOCl or 50-400 microM H2O2 plus myeloperoxidase and Cl-, there was progressive loss of tryptophan fluorescence and cysteines, and an increase in bityrosine fluorescence and carbonyl content.	dityrosine	203-213	myeloperoxidase	Homo sapiens	90-105
1691599-3	1990	Highly derivatized C18 (22 and 31%) columns from Phenomenex are run at pH 8.1 to separate dityrosine, the phosphorylated amino acids (o-phosphoserine, o-phosphothreonine, and o-phosphotyrosine), and the 17 other amino acids normally present in protein hydrolysates.	dityrosine	90-100	Bardet-Biedl syndrome 9	Homo sapiens	19-22
1691599-6	1990	This method has been applied to the analysis of dityrosine in uv-irradiated calmodulin and cardiac troponin C and to the detection of phosphorylation sites in several polypeptides.	dityrosine	48-58	calmodulin 1	Homo sapiens	76-86
1691599-6	1990	This method has been applied to the analysis of dityrosine in uv-irradiated calmodulin and cardiac troponin C and to the detection of phosphorylation sites in several polypeptides.	dityrosine	48-58	troponin C1, slow skeletal and cardiac type	Homo sapiens	91-109
34884761-0	2021	Dityrosine Crosslinking of Collagen and Amyloid-beta Peptides Is Formed by Vitamin B12 Deficiency-Generated Oxidative Stress in Caenorhabditis elegans.	dityrosine	0-10	Col_cuticle_N domain-containing protein	Caenorhabditis elegans	27-35
34884761-5	2021	Dityrosine crosslinking is involved in the extracellular maturation of worm collagen.	dityrosine	0-10	Col_cuticle_N domain-containing protein	Caenorhabditis elegans	76-84
34884761-6	2021	The dityrosine level of collagen significantly increased in the deficient worms compared with the control.	dityrosine	4-14	Col_cuticle_N domain-containing protein	Caenorhabditis elegans	24-32
34884761-8	2021	Moreover, using GMC101 mutant worms that express the full-length human amyloid beta, we found that vitamin B12 deficiency did not affect the gene and protein expressions of amyloid beta but increased the formation of dityrosine crosslinking in the amyloid beta protein.	dityrosine	217-227	amyloid beta precursor protein	Homo sapiens	71-83
34884761-8	2021	Moreover, using GMC101 mutant worms that express the full-length human amyloid beta, we found that vitamin B12 deficiency did not affect the gene and protein expressions of amyloid beta but increased the formation of dityrosine crosslinking in the amyloid beta protein.	dityrosine	217-227	amyloid beta precursor protein	Homo sapiens	248-260
34884761-10	2021	In GMC101 mutant worms, vitamin B12 deficiency-induced oxidative stress triggers dityrosine-crosslinked amyloid beta formation, which might promote its stabilization and toxic oligomerization.	dityrosine	81-91	amyloid beta precursor protein	Homo sapiens	104-116
34519476-3	2021	Amyloid-beta (Abeta) peptides which aggregate and accumulate in the plaques of Alzheimer"s disease (AD) have sequential N-terminal truncations and multiple post-translational modifications (PTM) such as isomerization, pyroglutamate formation, phosphorylation, nitration, and dityrosine cross-linking.	dityrosine	275-285	amyloid beta precursor protein	Homo sapiens	0-12
34519476-3	2021	Amyloid-beta (Abeta) peptides which aggregate and accumulate in the plaques of Alzheimer"s disease (AD) have sequential N-terminal truncations and multiple post-translational modifications (PTM) such as isomerization, pyroglutamate formation, phosphorylation, nitration, and dityrosine cross-linking.	dityrosine	275-285	amyloid beta precursor protein	Homo sapiens	14-19
34730552-8	2021	The induction of PXR by GSNO was mediated by the effect of the nitrosative stress product bityrosine on the transcription factor.	dityrosine	90-100	nuclear receptor subfamily 1 group I member 2	Homo sapiens	17-20
34730552-9	2021	It was shown that bityrosine at concentrations of 0,4 mM and 1 mM increased the amount of PXR.	dityrosine	18-28	nuclear receptor subfamily 1 group I member 2	Homo sapiens	90-93
8382689-0	1993	Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages.	dityrosine	0-10	myeloperoxidase	Homo sapiens	66-81
8382689-3	1993	Dityrosine synthesis by the myeloperoxidase-H2O2 system did not require halide and was partially inhibited by Cl-.	dityrosine	0-10	myeloperoxidase	Homo sapiens	28-43
8382689-4	1993	At physiological concentrations of Cl-, L-tyrosine, and other plasma amino acids, purified myeloperoxidase utilized 26% of the H2O2 in the reaction mixture to form dityrosine.	dityrosine	164-174	myeloperoxidase	Homo sapiens	91-106
2241176-8	1990	Bityrosines, which were identified by their specific fluorescence emission characteristics, were formed in reaction mixtures containing hemin and hydrogen peroxide and either spectrin or protein 4.1, but not actin.	dityrosine	0-11	erythrocyte membrane protein band 4.1	Homo sapiens	187-198
2249774-2	1990	Taking advantage of the natural fluorescence imparted to yeast spores by the presence of a dityrosine-containing macromolecule in the spore wall, we identified and cloned two genes, termed DIT1 and DIT2, which are required for spore wall maturation.	dityrosine	91-101	Dit1p	Saccharomyces cerevisiae S288C	189-193
2249774-2	1990	Taking advantage of the natural fluorescence imparted to yeast spores by the presence of a dityrosine-containing macromolecule in the spore wall, we identified and cloned two genes, termed DIT1 and DIT2, which are required for spore wall maturation.	dityrosine	91-101	putative cytochrome P450	Saccharomyces cerevisiae S288C	198-202
2249774-6	1990	Expression of the DIT and DIT2 genes is restricted to sporulating cells, with the DIT1 transcripts accumulating at the time of prospore enclosure and just prior to the time of dityrosine biosynthesis.	dityrosine	176-186	putative cytochrome P450	Saccharomyces cerevisiae S288C	26-30
2249774-6	1990	Expression of the DIT and DIT2 genes is restricted to sporulating cells, with the DIT1 transcripts accumulating at the time of prospore enclosure and just prior to the time of dityrosine biosynthesis.	dityrosine	176-186	Dit1p	Saccharomyces cerevisiae S288C	82-86
2249774-8	1990	As the DIT2 gene product has significant homology with cytochrome P-450s, DIT2 may be responsible for catalyzing the oxidation of tyrosine residues in the formation of dityrosine.	dityrosine	168-178	putative cytochrome P450	Saccharomyces cerevisiae S288C	7-11
2249774-8	1990	As the DIT2 gene product has significant homology with cytochrome P-450s, DIT2 may be responsible for catalyzing the oxidation of tyrosine residues in the formation of dityrosine.	dityrosine	168-178	putative cytochrome P450	Saccharomyces cerevisiae S288C	74-78
34829703-3	2021	In this study, we addressed the link between the H2O2-generating enzyme NADPH oxidase 4 (NOX4) and di-tyrosine (DT), an oxidative post-translational modification in IPF lungs.	dityrosine	99-110	NADPH oxidase 4	Homo sapiens	72-87
34829703-3	2021	In this study, we addressed the link between the H2O2-generating enzyme NADPH oxidase 4 (NOX4) and di-tyrosine (DT), an oxidative post-translational modification in IPF lungs.	dityrosine	99-110	NADPH oxidase 4	Homo sapiens	89-93
34829703-3	2021	In this study, we addressed the link between the H2O2-generating enzyme NADPH oxidase 4 (NOX4) and di-tyrosine (DT), an oxidative post-translational modification in IPF lungs.	dityrosine	112-114	NADPH oxidase 4	Homo sapiens	72-87
34829703-3	2021	In this study, we addressed the link between the H2O2-generating enzyme NADPH oxidase 4 (NOX4) and di-tyrosine (DT), an oxidative post-translational modification in IPF lungs.	dityrosine	112-114	NADPH oxidase 4	Homo sapiens	89-93
34829703-8	2021	Induction of NOX4 by Transforming growth factor beta 1 (TGFbeta1) in fibroblasts led to moderate DT staining after the addition of a heme-containing peroxidase in control cells but not in the fibroblasts deficient for NOX4 activity.	dityrosine	97-99	NADPH oxidase 4	Homo sapiens	13-17
34829703-8	2021	Induction of NOX4 by Transforming growth factor beta 1 (TGFbeta1) in fibroblasts led to moderate DT staining after the addition of a heme-containing peroxidase in control cells but not in the fibroblasts deficient for NOX4 activity.	dityrosine	97-99	transforming growth factor beta 1	Homo sapiens	21-54
34829703-8	2021	Induction of NOX4 by Transforming growth factor beta 1 (TGFbeta1) in fibroblasts led to moderate DT staining after the addition of a heme-containing peroxidase in control cells but not in the fibroblasts deficient for NOX4 activity.	dityrosine	97-99	transforming growth factor beta 1	Homo sapiens	56-64
34829703-9	2021	Our data indicate that DT is a histological marker of IPF and that NOX4 can generate a sufficient amount of H2O2 for DT formation in vitro.	dityrosine	23-25	NADPH oxidase 4	Homo sapiens	67-71
34829703-9	2021	Our data indicate that DT is a histological marker of IPF and that NOX4 can generate a sufficient amount of H2O2 for DT formation in vitro.	dityrosine	117-119	NADPH oxidase 4	Homo sapiens	67-71
35406715-3	2022	This study shows that exposure to inflammation-associated hypochlorite induces the oligomerisation of PAI-2 via a mechanism involving dityrosine formation.	dityrosine	134-144	serpin family B member 2	Homo sapiens	102-107
3567141-0	1987	Dityrosine formation in calmodulin.	dityrosine	0-10	calmodulin	Oryctolagus cuniculus	24-34
3567141-7	1987	Observations on the effects of UV irradiation on the thrombic fragments of calmodulin and on related calcium binding proteins (rabbit skeletal muscle troponin C, bovine cardiac troponin C, and parvalbumin) support the interpretation that dityrosine formation in calmodulin results from the intramolecular cross-linking of Tyr-99 and Tyr-138.	dityrosine	238-248	calmodulin	Oryctolagus cuniculus	75-85
3567141-7	1987	Observations on the effects of UV irradiation on the thrombic fragments of calmodulin and on related calcium binding proteins (rabbit skeletal muscle troponin C, bovine cardiac troponin C, and parvalbumin) support the interpretation that dityrosine formation in calmodulin results from the intramolecular cross-linking of Tyr-99 and Tyr-138.	dityrosine	238-248	calmodulin	Oryctolagus cuniculus	262-272
3567141-8	1987	The dityrosine-containing photoproduct of calmodulin is unable to stimulate the p-nitrophenyl phosphatase activity of calcineurin under standard assay conditions.	dityrosine	4-14	calmodulin	Oryctolagus cuniculus	42-52
2817362-2	1989	Ultraviolet irradiation of aqueous tyrosine solutions containing superoxide dismutase and catalase produces fluorescent dityrosine residues via dimerization of photogenerated tyrosyl radicals.	dityrosine	120-130	catalase	Homo sapiens	90-98
3182873-4	1988	The dityrosine content of the sperm whale myoglobin dimer shows that it is primarily held together by dityrosine cross-links, although more tyrosine residues are lost than are accounted for by dityrosine formation.	dityrosine	4-14	myoglobin	Physeter catodon	42-51
3182873-4	1988	The dityrosine content of the sperm whale myoglobin dimer shows that it is primarily held together by dityrosine cross-links, although more tyrosine residues are lost than are accounted for by dityrosine formation.	dityrosine	102-112	myoglobin	Physeter catodon	42-51
3182873-4	1988	The dityrosine content of the sperm whale myoglobin dimer shows that it is primarily held together by dityrosine cross-links, although more tyrosine residues are lost than are accounted for by dityrosine formation.	dityrosine	102-112	myoglobin	Physeter catodon	42-51
3182873-5	1988	Digestion of the myoglobin dimer with chymotrypsin yields a peptide with the fluorescence spectrum of dityrosine.	dityrosine	102-112	myoglobin	Physeter catodon	17-26
2452650-5	1988	The fluorescence intensity and anisotropy of the dityrosine moiety demonstrate that this novel derivative undergoes interactions with calcium, smooth muscle myosin light chain kinase, and phenylagarose which are similar to those of unmodified calmodulin.	dityrosine	49-59	myosin light chain kinase	Homo sapiens	143-182
2452650-5	1988	The fluorescence intensity and anisotropy of the dityrosine moiety demonstrate that this novel derivative undergoes interactions with calcium, smooth muscle myosin light chain kinase, and phenylagarose which are similar to those of unmodified calmodulin.	dityrosine	49-59	calmodulin 1	Homo sapiens	243-253
3349043-1	1988	We report dynamic fluorescence anisotropy measurements on the purified dityrosine derivative of calmodulin which was generated during UV irradiation of Ca2+-containing solutions of bovine brain calmodulin [Malencik, D. A., & Anderson, S. R. (1987) Biochemistry 26, 695].	dityrosine	71-81	calmodulin	Bos taurus	96-106
3349043-1	1988	We report dynamic fluorescence anisotropy measurements on the purified dityrosine derivative of calmodulin which was generated during UV irradiation of Ca2+-containing solutions of bovine brain calmodulin [Malencik, D. A., & Anderson, S. R. (1987) Biochemistry 26, 695].	dityrosine	71-81	calmodulin	Bos taurus	194-204
39419-5	1979	The possibility of dityrosine cross-linking in vivo in human oral fluid seems to be limited compared with e.g. human milk or macaque saliva where the concentration of SCN ions is low but the activity of lactoperoxidase is considerably high.	dityrosine	19-29	sorcin	Homo sapiens	167-170
3512567-9	1986	The same conclusion was reached independently by an investigation of spores of a strain homozygous for the mutation gcn1, which lack the outermost layers of the spore wall and were practically devoid of dityrosine.	dityrosine	203-213	Gcn1p	Saccharomyces cerevisiae S288C	116-120
18620142-4	1985	It is concluded that hydrogen peroxide is an endogenous, programmed product of the follicle cells, responsible for the action of peroxidase in order to oxidize the tyrosyl residues producing di-tyrosine and tri-tyrosine bonds between the chorion polypeptides.	dityrosine	191-202	Peroxidase	Drosophila melanogaster	129-139
6978319-1	1982	Lysozyme dimers produced on oxidation of lysozyme with Br2 radical in aqueous solutions exhibit a fluorescence spectrum (lambda max = 400 nm) closely similar to that of bi-tyrosine.	dityrosine	169-180	lysozyme	Homo sapiens	0-8
6978319-1	1982	Lysozyme dimers produced on oxidation of lysozyme with Br2 radical in aqueous solutions exhibit a fluorescence spectrum (lambda max = 400 nm) closely similar to that of bi-tyrosine.	dityrosine	169-180	lysozyme	Homo sapiens	41-49
157848-1	1979	The possible presence of dityrosine in elastin derived by two different methods and in structural glycoproteins from aortas of 1 day old chicks, adult rabbits and fetal rabbits was determined by a sensitive spectrofluorimetric procedure.	dityrosine	25-35	elastin	Oryctolagus cuniculus	39-46
33211011-0	2020	Megadalton-sized Dityrosine Aggregates of alpha-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics.	dityrosine	17-27	synuclein alpha	Homo sapiens	42-57
33317537-5	2020	Commonly, the presence of dityrosines that covalently link Resilin protein monomers (Pro-Resilin), which are responsible for its mechanical properties and fluoresce upon UV excitation, has been considered to reflect Resilin incidence.	dityrosine	26-37	resilin	Drosophila melanogaster	59-66
33317537-5	2020	Commonly, the presence of dityrosines that covalently link Resilin protein monomers (Pro-Resilin), which are responsible for its mechanical properties and fluoresce upon UV excitation, has been considered to reflect Resilin incidence.	dityrosine	26-37	resilin	Drosophila melanogaster	89-96
6030988-0	1967	Evidence for dityrosine in elastin.	dityrosine	13-23	elastin	Homo sapiens	27-34
33928788-6	2021	Nampt overexpression decreased the GSSG/GSH ratio, oxidation of thioredoxin 1 (Trx1) targets, dityrosine, and the accumulation of toxic lipids, including ceramides and diglycerides, in the presence of HFD consumption.	dityrosine	94-104	nicotinamide phosphoribosyltransferase	Mus musculus	0-5
33211011-3	2020	Here, we analyze the structural and dynamic properties of megadalton-sized dityrosine adducts of alphaSyn that form in the presence of reactive oxygen species and cytochrome c, a proapoptotic peroxidase that is released from mitochondria during sustained oxidative stress.	dityrosine	75-85	synuclein alpha	Homo sapiens	97-105
33211011-3	2020	Here, we analyze the structural and dynamic properties of megadalton-sized dityrosine adducts of alphaSyn that form in the presence of reactive oxygen species and cytochrome c, a proapoptotic peroxidase that is released from mitochondria during sustained oxidative stress.	dityrosine	75-85	cytochrome c, somatic	Homo sapiens	163-175
33211011-5	2020	We find that intermolecular dityrosine crosslinks restrict alphaSyn motions only locally whereas large segments of concatenated molecules remain flexible and disordered.	dityrosine	28-38	synuclein alpha	Homo sapiens	59-67
33211011-7	2020	We further establish that dityrosine adducts inhibit classical amyloid formation by maintaining alphaSyn in its monomeric form and that they are non-cytotoxic despite retaining basic membrane-binding properties.	dityrosine	26-36	synuclein alpha	Homo sapiens	96-104
32726960-5	2020	In this study, a library of tyrosine-to-phenylalanine (Y-to-F) NAcalpha-Syn constructs were designed in order to elucidate the nature and the precise residues involved in dityrosine crosslinking of Fe-bound NAcalpha-Syn.	dityrosine	171-181	nascent polypeptide associated complex subunit alpha	Homo sapiens	63-71
32786853-7	2020	Dityr interferes with T3 regulation of the myocardium via the PI3K/AKT/GSK3beta pathway, leading to myocardial mitochondrial damage and energy metabolism disorders.	dityrosine	0-5	thymoma viral proto-oncogene 1	Mus musculus	67-70
32786853-7	2020	Dityr interferes with T3 regulation of the myocardium via the PI3K/AKT/GSK3beta pathway, leading to myocardial mitochondrial damage and energy metabolism disorders.	dityrosine	0-5	glycogen synthase kinase 3 alpha	Mus musculus	71-79
32726960-2	2020	In PD, these NAcalpha-Syn aggregates have been found to contain covalent dityrosine crosslinks, which can occur either intermolecularly or intramolecularly.	dityrosine	73-83	nascent polypeptide associated complex subunit alpha	Homo sapiens	13-21
32726960-2	2020	In PD, these NAcalpha-Syn aggregates have been found to contain covalent dityrosine crosslinks, which can occur either intermolecularly or intramolecularly.	dityrosine	73-83	synemin	Homo sapiens	22-25
32726960-4	2020	NAcalpha-Syn is an intrinsically disordered protein, and metal-mediated conformational modifications of this structurally dynamic protein have been demonstrated to influence its propensity for dityrosine formation.	dityrosine	193-203	nascent polypeptide associated complex subunit alpha	Homo sapiens	0-8
32726960-4	2020	NAcalpha-Syn is an intrinsically disordered protein, and metal-mediated conformational modifications of this structurally dynamic protein have been demonstrated to influence its propensity for dityrosine formation.	dityrosine	193-203	synemin	Homo sapiens	9-12
32788339-4	2020	We found that cellular (fibrillar) fibronectin on the surface of transforming growth factor-beta1 (TGF-beta1)-activated human myofibroblasts underwent multimerization by o,o"-dityrosine cross-linking under reducing conditions that disrupt disulfide bridges, but soluble fibronectin did not.	dityrosine	170-185	fibronectin 1	Homo sapiens	35-46
32788339-4	2020	We found that cellular (fibrillar) fibronectin on the surface of transforming growth factor-beta1 (TGF-beta1)-activated human myofibroblasts underwent multimerization by o,o"-dityrosine cross-linking under reducing conditions that disrupt disulfide bridges, but soluble fibronectin did not.	dityrosine	170-185	transforming growth factor beta 1	Homo sapiens	65-97
32788339-4	2020	We found that cellular (fibrillar) fibronectin on the surface of transforming growth factor-beta1 (TGF-beta1)-activated human myofibroblasts underwent multimerization by o,o"-dityrosine cross-linking under reducing conditions that disrupt disulfide bridges, but soluble fibronectin did not.	dityrosine	170-185	transforming growth factor beta 1	Homo sapiens	99-108
32788339-7	2020	The abundance of circulating o,o"-dityrosine-modified fibronectin was increased in a murine model of lung fibrosis and in human subjects with interstitial lung disease compared to that in control healthy subjects.	dityrosine	29-44	fibronectin 1	Mus musculus	54-65
32726960-5	2020	In this study, a library of tyrosine-to-phenylalanine (Y-to-F) NAcalpha-Syn constructs were designed in order to elucidate the nature and the precise residues involved in dityrosine crosslinking of Fe-bound NAcalpha-Syn.	dityrosine	171-181	synemin	Homo sapiens	72-75
32726960-6	2020	The structural capacity of each mutant to form dityrosine crosslinks was assessed using Photo-Induced Cross-Linking of Unmodified Proteins (PICUP), demonstrating that coordination of either FeIII or FeII to NAcalpha-Syn inhibits dityrosine crosslinking among the C-terminal residues.	dityrosine	47-57	nascent polypeptide associated complex subunit alpha	Homo sapiens	207-215
32726960-6	2020	The structural capacity of each mutant to form dityrosine crosslinks was assessed using Photo-Induced Cross-Linking of Unmodified Proteins (PICUP), demonstrating that coordination of either FeIII or FeII to NAcalpha-Syn inhibits dityrosine crosslinking among the C-terminal residues.	dityrosine	229-239	nascent polypeptide associated complex subunit alpha	Homo sapiens	207-215
32726960-7	2020	We further demonstrate that Y39 is the main contributor to dityrosine formation of Fe-bound NAcalpha-Syn, while Y125 is the main residue involved in dityrosine crosslinks in unmetalated NAcalpha-Syn.	dityrosine	59-69	nascent polypeptide associated complex subunit alpha	Homo sapiens	92-100
32726960-7	2020	We further demonstrate that Y39 is the main contributor to dityrosine formation of Fe-bound NAcalpha-Syn, while Y125 is the main residue involved in dityrosine crosslinks in unmetalated NAcalpha-Syn.	dityrosine	59-69	synemin	Homo sapiens	101-104
32726960-7	2020	We further demonstrate that Y39 is the main contributor to dityrosine formation of Fe-bound NAcalpha-Syn, while Y125 is the main residue involved in dityrosine crosslinks in unmetalated NAcalpha-Syn.	dityrosine	149-159	nascent polypeptide associated complex subunit alpha	Homo sapiens	186-194
31490671-1	2019	Dityrosine cross-linking of Abeta peptides and alpha-synuclein is increasingly becoming recognized as a biomarker of neuropathological diseases.	dityrosine	0-10	synuclein alpha	Homo sapiens	47-62
31490671-6	2019	In combination with dedicated MS-cleavable MSn software, UVPD-MSn therefore provides an avenue to selectively discover and describe dityrosine cross-linked peptides.	dityrosine	132-142	moesin	Homo sapiens	43-46
31490671-6	2019	In combination with dedicated MS-cleavable MSn software, UVPD-MSn therefore provides an avenue to selectively discover and describe dityrosine cross-linked peptides.	dityrosine	132-142	moesin	Homo sapiens	62-65
30620180-0	2019	Modulation of alpha-Synuclein Aggregation by Cytochrome c Binding and Hetero-dityrosine Adduct Formation.	dityrosine	77-87	synuclein alpha	Homo sapiens	14-29
31175983-2	2019	Nitration/oxidation of alphaSyn leads to dityrosine crosslinking and aggregation.	dityrosine	41-51	synuclein, alpha	Mus musculus	23-31
31059754-3	2019	Oxidation of RNase A leads to intermolecular dityrosine (DT) bond formation which shows a characteristic fluorescence emission around 405 nm.	dityrosine	45-55	ribonuclease A family member 1, pancreatic	Homo sapiens	13-20
31059754-3	2019	Oxidation of RNase A leads to intermolecular dityrosine (DT) bond formation which shows a characteristic fluorescence emission around 405 nm.	dityrosine	57-59	ribonuclease A family member 1, pancreatic	Homo sapiens	13-20
31238865-10	2019	MPO-dependent oxidation of free tyrosine results in the formation of tyrosyl radicals, that do not oxidize aromatic amino acid residues in proteins because of the high rate of recombination with dityrosine formation.	dityrosine	195-205	myeloperoxidase	Homo sapiens	0-3
30926832-5	2019	The Slf protein mainly localizes between the two layers called epicuticle and procuticle that separate from each other when the function of Slf is reduced or eliminated paralleling the phenotype of a cuticle with reduced extracellular dityrosine.	dityrosine	235-245	slf	Drosophila melanogaster	4-7
30926832-6	2019	Localisation of the dityrosinylated protein Resilin to the epicuticle-procuticle interface suggests that the dityrosine network mediates the adhesion of the epicuticle to the procuticle.	dityrosine	109-119	resilin	Drosophila melanogaster	44-51
30926832-8	2019	In summary, we propose that Slf is implied in the stabilisation of a dityrosine layer especially between the epicuticle and the procuticle that in turn constitutes an outward barrier against uncontrolled water flow.	dityrosine	69-79	slf	Drosophila melanogaster	28-31
30620180-4	2019	Here, we report an in vitro investigation of the interaction between alpha-Syn and cytochrome c in the oxidized (cyt c III) and reduced forms (cyt c II), in which cyt c III was found to induce a large compaction of alpha-Syn and inhibit the aggregation by favoring a hetero-dityrosine bond formation.	dityrosine	274-284	synuclein alpha	Homo sapiens	69-78
30620180-4	2019	Here, we report an in vitro investigation of the interaction between alpha-Syn and cytochrome c in the oxidized (cyt c III) and reduced forms (cyt c II), in which cyt c III was found to induce a large compaction of alpha-Syn and inhibit the aggregation by favoring a hetero-dityrosine bond formation.	dityrosine	274-284	cytochrome c, somatic	Homo sapiens	83-95
29191462-0	2018	Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function.	dityrosine	96-107	elastin	Homo sapiens	12-24
30737030-5	2019	Here, we show that such a process, which involves Cu(II) ions bound to the IAPP peptide together with H2O2, can induce formation of large amounts of IAPP dimers connected by covalent dityrosine cross-links.	dityrosine	183-193	islet amyloid polypeptide	Homo sapiens	75-79
30737030-5	2019	Here, we show that such a process, which involves Cu(II) ions bound to the IAPP peptide together with H2O2, can induce formation of large amounts of IAPP dimers connected by covalent dityrosine cross-links.	dityrosine	183-193	islet amyloid polypeptide	Homo sapiens	149-153
30465671-9	2019	In addition, we examined the ability of dityrosine cross-linked alpha-synuclein oligomers to bind Cu, Fe and Zn.	dityrosine	40-50	synuclein alpha	Homo sapiens	64-79
30320292-6	2018	Both these nanoparticles show a reduction in dityrosine formation in RNase A caused due to oxidative stress and also prevent RNase A dimer formation to different extents depending on their concentration.	dityrosine	45-55	ribonuclease A family member 1, pancreatic	Homo sapiens	69-76
29581235-5	2018	MPO expression and oxidation products-protein-bound oxidized tyrosine moieties 3-chlorotyrosine, 3-nitrotyrosine, and o,o"-dityrosine-were examined with immunoassays and confirmed with mass spectrometry (MS).	dityrosine	118-133	myeloperoxidase	Mus musculus	0-3
29537826-7	2018	Third, we applied these MS methods to the analysis of brain Abeta dimer samples allowing the detection of the CL [Abeta(6-16)]2 peptide comprising a dityrosine cross-link.	dityrosine	149-159	amyloid beta precursor protein	Homo sapiens	60-65
29537826-7	2018	Third, we applied these MS methods to the analysis of brain Abeta dimer samples allowing the detection of the CL [Abeta(6-16)]2 peptide comprising a dityrosine cross-link.	dityrosine	149-159	amyloid beta precursor protein	Homo sapiens	114-119
33405750-4	2019	Herein, we fabricated a 3D bioengineered pulmonary fibrotic (Eng-PF) tissue utilizing cell laden silk collagen type I dityrosine cross-linked hydrogels and Flexcell bioreactors.	dityrosine	118-128	endoglin	Homo sapiens	61-64
30222205-6	2018	DT was more highly expressed in AK, BD and SCC than in the controls.	dityrosine	0-2	serpin family B member 3	Homo sapiens	43-46
30385800-0	2018	Copper Redox Cycling Inhibits Abeta Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Abeta Dimer.	dityrosine	105-115	amyloid beta precursor protein	Homo sapiens	116-121
30385800-4	2018	Using fluorescence measurements and UV absorbance, we show that dityrosine can be formed aerobically when Abeta is incubated with Cu2+ and hydrogen-peroxide, or in a Cu2+ and ascorbate redox mixture.	dityrosine	64-74	amyloid beta precursor protein	Homo sapiens	106-111
30385800-5	2018	The dityrosine cross-linking can occur for both monomeric and fibrillar forms of Abeta.	dityrosine	4-14	amyloid beta precursor protein	Homo sapiens	81-86
28978675-6	2017	The spore wall is a multilaminar structure and SRT1 is required for the generation of the outer chitosan and dityrosine layers of the spore wall.	dityrosine	109-119	ditrans,polycis-polyprenyl diphosphate synthase	Saccharomyces cerevisiae S288C	47-51
29139109-2	2018	Ribonuclease A (RNase A) has 6 Tyr residues and shows a characteristic DT fluorescence peak upon oxidation in addition to major changes in its secondary structure.	dityrosine	71-73	ribonuclease A family member 1, pancreatic	Homo sapiens	0-14
29139109-2	2018	Ribonuclease A (RNase A) has 6 Tyr residues and shows a characteristic DT fluorescence peak upon oxidation in addition to major changes in its secondary structure.	dityrosine	71-73	ribonuclease A family member 1, pancreatic	Homo sapiens	16-23
29332049-8	2018	Also by studying Y10 as an endogenous peroxidase substrate for Abeta-heme complexes, ratio-specific effects were observed, showing an optimal dityrosine formation at an about 40-fold peptide excess.	dityrosine	142-152	amyloid beta precursor protein	Homo sapiens	63-68
27140235-6	2016	The content of bityrosine increased markedly, suggesting that the oxidized HSA was aggregated.	dityrosine	15-25	albumin	Homo sapiens	75-78
28918091-0	2017	Opposed Effects of Dityrosine Formation in Soluble and Aggregated alpha-Synuclein on Fibril Growth.	dityrosine	19-29	synuclein alpha	Homo sapiens	66-81
28918091-3	2017	Oxidative stress leads to several modifications of biomolecules including dityrosine (DiY) crosslinking in proteins, which has recently been detected in alpha-syn in Lewy bodies from Parkinson"s disease patients.	dityrosine	74-84	synuclein alpha	Homo sapiens	153-162
28918091-3	2017	Oxidative stress leads to several modifications of biomolecules including dityrosine (DiY) crosslinking in proteins, which has recently been detected in alpha-syn in Lewy bodies from Parkinson"s disease patients.	dityrosine	86-89	synuclein alpha	Homo sapiens	153-162
27982082-0	2016	The involvement of dityrosine crosslinking in alpha-synuclein assembly and deposition in Lewy Bodies in Parkinson"s disease.	dityrosine	19-29	synuclein alpha	Homo sapiens	46-61
27982082-5	2016	In vitro, we show that dityrosine cross-links in alpha-syn are formed by covalent ortho-ortho coupling of two tyrosine residues under conditions of oxidative stress by fluorescence and confirmed using mass-spectrometry.	dityrosine	23-33	synuclein alpha	Homo sapiens	49-58
27982082-7	2016	Atomic force microscopy analysis reveals that the covalent dityrosine contributes to the stabilization of alpha-syn assemblies.	dityrosine	59-69	synuclein alpha	Homo sapiens	106-115
27982082-8	2016	Thus, the presence of oxidative stress induced dityrosine could play an important role in assembly and toxicity of alpha-syn in PD.	dityrosine	47-57	synuclein alpha	Homo sapiens	115-124
28863941-6	2017	Oxidation of lipids was assessed by the formation of conjugated diene/triene and malondialdehyde, and oxidation of MBP was demonstrated by the bityrosine formation and by the change in protein mass.	dityrosine	143-153	myelin basic protein	Homo sapiens	115-118
28548821-6	2017	Meanwhile, applying electrochemical potential scanning to this sensing surface, Cu binding fragments of the probe peptide can be released into the solution phase to act as an electrochemical catalyst for oxidative dityrosine cross-linking among all proteins including the captured cathepsin B and the nonspecific proteins.	dityrosine	214-224	cathepsin B	Homo sapiens	281-292
28453255-6	2017	Application of these generic fragmentation rules of dityrosine cross-linked peptides allowed for the identification of dityrosine cross-links in peptides of Abeta and alpha-synuclein generated in vitro by enzymatic peroxidation.	dityrosine	52-62	synuclein alpha	Homo sapiens	167-182
28453255-6	2017	Application of these generic fragmentation rules of dityrosine cross-linked peptides allowed for the identification of dityrosine cross-links in peptides of Abeta and alpha-synuclein generated in vitro by enzymatic peroxidation.	dityrosine	119-129	synuclein alpha	Homo sapiens	167-182
28453255-7	2017	We report, for the first time, the dityrosine cross-linked residues in human hemoglobin and alpha-synuclein under oxidative conditions.	dityrosine	35-45	synuclein alpha	Homo sapiens	92-107
28542575-5	2017	In addition, melatonin increased dityrosine levels but suppressed nitrite levels by upregulating the expression of Nrf2 and heme oxygenase-1 in the Nrf2 antioxidant defense pathway.	dityrosine	33-43	NFE2 like bZIP transcription factor 2	Bos taurus	148-152
27140231-0	2016	NADPH oxidase 4 deficiency leads to impaired wound repair and reduced dityrosine-crosslinking, but does not affect myofibroblast formation.	dityrosine	70-80	NADPH oxidase 4	Mus musculus	0-15
27317839-9	2016	Furthermore, we found that dityrosine-ingested mice showed decreased expression level of NMDA receptor subunits Nr1, Nr2a, Nr2b as well as Bdnf, Trkb.	dityrosine	27-37	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	112-115
27317839-9	2016	Furthermore, we found that dityrosine-ingested mice showed decreased expression level of NMDA receptor subunits Nr1, Nr2a, Nr2b as well as Bdnf, Trkb.	dityrosine	27-37	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	117-121
27317839-9	2016	Furthermore, we found that dityrosine-ingested mice showed decreased expression level of NMDA receptor subunits Nr1, Nr2a, Nr2b as well as Bdnf, Trkb.	dityrosine	27-37	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	123-127
27317839-9	2016	Furthermore, we found that dityrosine-ingested mice showed decreased expression level of NMDA receptor subunits Nr1, Nr2a, Nr2b as well as Bdnf, Trkb.	dityrosine	27-37	brain derived neurotrophic factor	Mus musculus	139-143
27317839-9	2016	Furthermore, we found that dityrosine-ingested mice showed decreased expression level of NMDA receptor subunits Nr1, Nr2a, Nr2b as well as Bdnf, Trkb.	dityrosine	27-37	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	145-149
27317839-10	2016	Our study suggests that dityrosine exposure impairs hippocampus-dependent nonspatial memory accompanied by modulation of NMDA receptor subunits and Bdnf expression.	dityrosine	24-34	brain derived neurotrophic factor	Mus musculus	148-152
27475778-0	2016	DNA melting properties of the dityrosine cross-linked dimer of Ribonuclease A.	dityrosine	30-40	ribonuclease A family member 1, pancreatic	Homo sapiens	63-77
27475778-3	2016	In the present study, we have compared the DNA binding properties between the RNase A monomer and the dityrosine (DT) cross-linked RNase A dimer, and checked the inhibitory effect of DNA on the ribonucleolytic activity of the dimeric protein.	dityrosine	102-112	ribonuclease A family member 1, pancreatic	Homo sapiens	131-138
27475778-3	2016	In the present study, we have compared the DNA binding properties between the RNase A monomer and the dityrosine (DT) cross-linked RNase A dimer, and checked the inhibitory effect of DNA on the ribonucleolytic activity of the dimeric protein.	dityrosine	114-116	ribonuclease A family member 1, pancreatic	Homo sapiens	131-138
27396946-5	2016	Here we demonstrate that Tyr and Trp residues on human plasma fibronectin are highly sensitive to ONOOH with this resulting in the formation of 3-nitrotyrosine, 6-nitrotryptophan and dityrosine as well as protein aggregation and fragmentation.	dityrosine	183-193	fibronectin 1	Homo sapiens	62-73
27140231-9	2016	Strong dityrosine formation was observed, but was significantly weaker in NOX4-/- mice (p<0.05).	dityrosine	7-17	NADPH oxidase 4	Mus musculus	74-78
27140231-15	2016	We suggest that myofibroblast contraction in NOX4-deficient mice is less effective in contracting the wound because of insufficient dityrosine-crosslinking of the ECM, providing the first indication for a physiological function of dityrosine crosslinking in higher animals.	dityrosine	132-142	NADPH oxidase 4	Mus musculus	45-49
27140231-15	2016	We suggest that myofibroblast contraction in NOX4-deficient mice is less effective in contracting the wound because of insufficient dityrosine-crosslinking of the ECM, providing the first indication for a physiological function of dityrosine crosslinking in higher animals.	dityrosine	231-241	NADPH oxidase 4	Mus musculus	45-49
26928584-5	2016	This early oxidative stress was responsible for the oxidation of EGFR and the formation of sodium dodecyl sulfate (SDS) stable EGFR dimers through dityrosine cross-linking.	dityrosine	147-157	epidermal growth factor receptor	Homo sapiens	127-131
27341336-8	2016	Analysis of tyrosine residues involved in nitration and crosslinking revealed that the C-terminus, rather than the N-terminus of alphaSyn, is modified by nitration and di-tyrosine formation.	dityrosine	168-179	synuclein alpha	Homo sapiens	129-137
28232892-5	2015	Here, we present evidence for the spontaneous formation of covalent di-tyrosine alpha-synuclein dimers in standard recombinant protein preparations, induced without extrinsic oxidative or nitrative agents.	dityrosine	68-79	synuclein alpha	Homo sapiens	80-95
27229173-0	2016	Haem-assisted dityrosine-cross-linking of fibrinogen under non-thermal plasma exposure: one important mechanism of facilitated blood coagulation.	dityrosine	14-24	fibrinogen beta chain	Homo sapiens	42-52
27229173-3	2016	The reason for the haem role is due to that its oxidized form, namely, hematin, can promote the dityrosine cross-linking of fibrinogen, the most important coagulation protein, to form a membrane-like layer on the surface of the treated blood with plasma exposure.	dityrosine	96-106	fibrinogen beta chain	Homo sapiens	124-134
27229173-5	2016	We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation.	dityrosine	203-213	fibrinogen beta chain	Homo sapiens	18-28
27229173-5	2016	We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation.	dityrosine	203-213	fibrinogen beta chain	Homo sapiens	232-242
26077029-5	2016	The formation of dityrosine was detected in SAL-mediated hCP aggregates.	dityrosine	17-27	coproporphyrinogen oxidase	Homo sapiens	57-60
26536630-5	2016	The carbonyl content and dityrosine were markedly elevated in peroxynitrite-modified H2B histone as compared to the native histone.	dityrosine	25-35	H2B clustered histone 21	Homo sapiens	85-88
26728129-5	2016	The interaction of ZnT10 with ZnT3, mediated by dityrosine bonds, was unable to target ZnT10 into SLMVs in vitro or into synaptic vesicles isolated from mouse brain in vivo.	dityrosine	48-58	solute carrier family 30, member 10	Mus musculus	19-24
26728129-5	2016	The interaction of ZnT10 with ZnT3, mediated by dityrosine bonds, was unable to target ZnT10 into SLMVs in vitro or into synaptic vesicles isolated from mouse brain in vivo.	dityrosine	48-58	solute carrier family 30 (zinc transporter), member 3	Mus musculus	30-34
26728129-7	2016	Further, mutation of tyrosine 4 in ZnT10 reduced ZnT3/ZnT10 dityrosine-mediated heterodimerization and zinc transport, as well as MEK and ERK1/2 phosphorylation, which were also reduced by the zinc chelator TPEN.	dityrosine	60-70	solute carrier family 30, member 10	Mus musculus	35-40
26728129-7	2016	Further, mutation of tyrosine 4 in ZnT10 reduced ZnT3/ZnT10 dityrosine-mediated heterodimerization and zinc transport, as well as MEK and ERK1/2 phosphorylation, which were also reduced by the zinc chelator TPEN.	dityrosine	60-70	solute carrier family 30 member 3	Rattus norvegicus	49-53
26728129-7	2016	Further, mutation of tyrosine 4 in ZnT10 reduced ZnT3/ZnT10 dityrosine-mediated heterodimerization and zinc transport, as well as MEK and ERK1/2 phosphorylation, which were also reduced by the zinc chelator TPEN.	dityrosine	60-70	solute carrier family 30, member 10	Mus musculus	54-59
25386651-5	2014	We here show that UVB illumination of the extracellular domain of EGFR (sEGFR) induces protein conformational changes, disulphide bridge breakage and formation of tryptophan and tyrosine photoproducts such as dityrosine, N-formylkynurenine and kynurenine.	dityrosine	209-219	epidermal growth factor receptor	Homo sapiens	66-70
28725173-0	2015	Identification of multiple dityrosine bonds in materials composed of the Drosophila protein Ultrabithorax.	dityrosine	27-37	Ultrabithorax	Drosophila melanogaster	92-105
25280629-6	2015	Differently, incubation of fibrinogen or HSA/fibrinogen mixtures with HOCl at concentrations higher than 150 muM induced the formation of pentosidine and high molecular weight (HMW)-AOPPs (>200 k Da), resulting from intermolecular dityrosine cross-linking.	dityrosine	234-244	fibrinogen beta chain	Homo sapiens	27-37
25280629-6	2015	Differently, incubation of fibrinogen or HSA/fibrinogen mixtures with HOCl at concentrations higher than 150 muM induced the formation of pentosidine and high molecular weight (HMW)-AOPPs (>200 k Da), resulting from intermolecular dityrosine cross-linking.	dityrosine	234-244	albumin	Homo sapiens	41-44
25280629-6	2015	Differently, incubation of fibrinogen or HSA/fibrinogen mixtures with HOCl at concentrations higher than 150 muM induced the formation of pentosidine and high molecular weight (HMW)-AOPPs (>200 k Da), resulting from intermolecular dityrosine cross-linking.	dityrosine	234-244	fibrinogen beta chain	Homo sapiens	45-55
25280629-7	2015	Dityrosine fluorescence increased in parallel with increasing HMW-AOPP formation and increasing fibrinogen concentration in HSA/fibrinogen mixtures exposed to HOCl.	dityrosine	0-10	fibrinogen beta chain	Homo sapiens	96-106
25280629-7	2015	Dityrosine fluorescence increased in parallel with increasing HMW-AOPP formation and increasing fibrinogen concentration in HSA/fibrinogen mixtures exposed to HOCl.	dityrosine	0-10	albumin	Homo sapiens	124-127
25280629-7	2015	Dityrosine fluorescence increased in parallel with increasing HMW-AOPP formation and increasing fibrinogen concentration in HSA/fibrinogen mixtures exposed to HOCl.	dityrosine	0-10	fibrinogen beta chain	Homo sapiens	128-138
25280629-8	2015	This conclusion is corroborated by experiments where dityrosine fluorescence was measured in HOCl-treated human plasma samples containing physiological or supra-physiological fibrinogen concentrations or selectively depleted of fibrinogen, which highlighted that fibrinogen is responsible for the highest fluorescence from dityrosine.	dityrosine	53-63	fibrinogen beta chain	Homo sapiens	175-185
25280629-8	2015	This conclusion is corroborated by experiments where dityrosine fluorescence was measured in HOCl-treated human plasma samples containing physiological or supra-physiological fibrinogen concentrations or selectively depleted of fibrinogen, which highlighted that fibrinogen is responsible for the highest fluorescence from dityrosine.	dityrosine	53-63	fibrinogen beta chain	Homo sapiens	228-238
25280629-8	2015	This conclusion is corroborated by experiments where dityrosine fluorescence was measured in HOCl-treated human plasma samples containing physiological or supra-physiological fibrinogen concentrations or selectively depleted of fibrinogen, which highlighted that fibrinogen is responsible for the highest fluorescence from dityrosine.	dityrosine	53-63	fibrinogen beta chain	Homo sapiens	228-238
25280629-9	2015	CONCLUSIONS: A central role for intermolecular dityrosine cross-linking of fibrinogen in HMW-AOPP formation is shown.	dityrosine	47-57	fibrinogen beta chain	Homo sapiens	75-85
25280629-10	2015	GENERAL SIGNIFICANCE: These results highlight that oxidized fibrinogen, instead of HSA, is the key protein for intermolecular dityrosine formation in human plasma.	dityrosine	126-136	fibrinogen beta chain	Homo sapiens	60-70
25280629-0	2015	A central role for intermolecular dityrosine cross-linking of fibrinogen in high molecular weight advanced oxidation protein product (AOPP) formation.	dityrosine	34-44	fibrinogen beta chain	Homo sapiens	62-72
24351276-0	2013	A central role for dityrosine crosslinking of Amyloid-beta in Alzheimer"s disease.	dityrosine	19-29	amyloid beta precursor protein	Homo sapiens	46-58
24906676-5	2014	The assay demonstrated the potential for arNOX-induced oxidative damage (dityrosine formation) to human collagen and elastin and to other surface proteins of intact human embryo fibroblasts and frozen sections from epidermal punch biopsies.	dityrosine	73-83	elastin	Homo sapiens	117-124
24907339-4	2014	Thus, removal of the outermost dityrosine layer by disruption of the DIT1 gene, which is required for dityrosine synthesis, leads to exposure of the chitosan layer at the spore surface.	dityrosine	31-41	Dit1p	Saccharomyces cerevisiae S288C	69-73
24907339-4	2014	Thus, removal of the outermost dityrosine layer by disruption of the DIT1 gene, which is required for dityrosine synthesis, leads to exposure of the chitosan layer at the spore surface.	dityrosine	102-112	Dit1p	Saccharomyces cerevisiae S288C	69-73
25220661-8	2014	The results are consolidated into a model in which caddisfly silk Pxt-catalyzed dityrosine crosslinking occurs post-draw using H2O2 generated within the silk fibers by SOD3.	dityrosine	80-90	superoxide dismutase 3	Homo sapiens	168-172
24785004-2	2014	In the absence of sufficient brain-derived dimers, we studied one of the only possible dimers that could be produced in vivo, [Abeta](DiY) (dityrosine cross-linked Abeta).	dityrosine	140-150	amyloid beta precursor protein	Homo sapiens	127-132
23848532-6	2014	Submicromolar concentrations of GKT136901 prevented tyrosine nitration and di-tyrosine-dependent dimer formation of ASYN by PON as indicated by Western blot and mass spectrometric analysis.	dityrosine	75-86	synuclein alpha	Homo sapiens	116-120
24351276-4	2013	RESULTS: We have investigated the formation of dityrosine cross-links in Abeta42 formed by covalent ortho-ortho coupling of two tyrosine residues under conditions of oxidative stress with elevated copper and shown that dityrosine can be formed in vitro in Abeta oligomers and fibrils and that these links further stabilize the fibrils.	dityrosine	47-57	amyloid beta precursor protein	Homo sapiens	73-78
24351276-4	2013	RESULTS: We have investigated the formation of dityrosine cross-links in Abeta42 formed by covalent ortho-ortho coupling of two tyrosine residues under conditions of oxidative stress with elevated copper and shown that dityrosine can be formed in vitro in Abeta oligomers and fibrils and that these links further stabilize the fibrils.	dityrosine	219-229	amyloid beta precursor protein	Homo sapiens	73-78
24351276-5	2013	Dityrosine crosslinking was present in internalized Abeta in cell cultures treated with oligomeric Abeta42 using a specific antibody for dityrosine by immunogold labeling transmission electron microscopy.	dityrosine	0-10	amyloid beta precursor protein	Homo sapiens	52-57
24351276-5	2013	Dityrosine crosslinking was present in internalized Abeta in cell cultures treated with oligomeric Abeta42 using a specific antibody for dityrosine by immunogold labeling transmission electron microscopy.	dityrosine	137-147	amyloid beta precursor protein	Homo sapiens	52-57
24351276-7	2013	CONCLUSIONS: Abeta dimers may be stabilized by dityrosine crosslinking.	dityrosine	47-57	amyloid beta precursor protein	Homo sapiens	13-18
23348078-0	2013	New strategy for selective and sensitive assay of cathepsin B using a dityrosine-based material.	dityrosine	70-80	cathepsin B	Homo sapiens	50-61
23932592-4	2013	The crystal structure of the Syntaxin 6 Habc domain in complex with a peptide from the N terminus of Ang2 shows a binding mode in which a dityrosine motif of Ang2 interacts with a highly conserved groove in Syntaxin 6.	dityrosine	138-148	syntaxin 6	Homo sapiens	29-39
23932592-4	2013	The crystal structure of the Syntaxin 6 Habc domain in complex with a peptide from the N terminus of Ang2 shows a binding mode in which a dityrosine motif of Ang2 interacts with a highly conserved groove in Syntaxin 6.	dityrosine	138-148	angiopoietin 2	Homo sapiens	101-105
23932592-4	2013	The crystal structure of the Syntaxin 6 Habc domain in complex with a peptide from the N terminus of Ang2 shows a binding mode in which a dityrosine motif of Ang2 interacts with a highly conserved groove in Syntaxin 6.	dityrosine	138-148	angiopoietin 2	Homo sapiens	158-162
23932592-4	2013	The crystal structure of the Syntaxin 6 Habc domain in complex with a peptide from the N terminus of Ang2 shows a binding mode in which a dityrosine motif of Ang2 interacts with a highly conserved groove in Syntaxin 6.	dityrosine	138-148	syntaxin 6	Homo sapiens	207-217
23228886-4	2013	The formation of carbonyl compounds and dityrosine were observed in the THP-mediated NF-L aggregates.	dityrosine	40-50	neurofilament light chain	Homo sapiens	85-89
22554148-2	2012	Using a tandem modular protein (GB1)(8) as building blocks, we have engineered chemically cross-linked hydrogels via a photochemical cross-linking strategy, which is based on the cross-linking of two adjacent tyrosine residues into dityrosine adducts.	dityrosine	232-242	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	32-35
22293958-6	2012	Concomitantly, reduction of Alas function results in weakening of the extracellular dityrosines network in the cuticle, whereas glutamyl-lysine isopeptide bonds are not affected.	dityrosine	84-95	Aminolevulinate synthase	Drosophila melanogaster	28-32
22293958-8	2012	Taken together, we hypothesise that Alas activity, which initiates heme biosynthesis in the mitochondrion, is needed for the formation of a dityrosine-based barrier that confers resistance to the internal hydrostatic pressure protecting both the cuticle from transcellular infiltration of body fluid and the animal from dehydration.	dityrosine	140-150	Aminolevulinate synthase	Drosophila melanogaster	36-40
22085605-9	2012	IL-6 levels were directly correlated with di-Tyr and inversely correlated with GPx activity.	dityrosine	42-48	interleukin 6	Homo sapiens	0-4
22112843-7	2012	MPO-induced oxidation of tyrosine is relevant to what can be in vivo; we detected MPO-catalyzed formation of dityrosine in the presence of plasma under experimental conditions when tyrosine concentration was about three magnitudes of order less than the Cl(-) concentration.	dityrosine	109-119	myeloperoxidase	Homo sapiens	0-3
21997333-6	2012	Cigarette smoke caused a marked increase in immunohistochemical staining for the myeloperoxidase-generated protein oxidation marker dityrosine, and this effect was considerably decreased with both treatment arms.	dityrosine	132-142	myeloperoxidase	Cavia porcellus	81-96
22112843-7	2012	MPO-induced oxidation of tyrosine is relevant to what can be in vivo; we detected MPO-catalyzed formation of dityrosine in the presence of plasma under experimental conditions when tyrosine concentration was about three magnitudes of order less than the Cl(-) concentration.	dityrosine	109-119	myeloperoxidase	Homo sapiens	82-85
21808060-8	2011	Along with this observation, analysis of the catecholic and dityrosine components in the wings of adult flies proved that dDuox plays important roles in the stabilization of the cuticle structure of the wings via tyrosine cross-linking, the sclerotization and melanization processes possibly through ROS production.	dityrosine	60-70	Dual oxidase	Drosophila melanogaster	122-127
22528079-3	2012	Here we report a simple and reproducible method for the production of radically derived dityrosine cross-linked oligomers of Abeta, through reaction with copper and ascorbic acid.	dityrosine	88-98	amyloid beta precursor protein	Homo sapiens	125-130
21798344-0	2011	Vascular peroxidase-1 is rapidly secreted, circulates in plasma, and supports dityrosine cross-linking reactions.	dityrosine	78-88	peroxidasin	Homo sapiens	0-21
21798344-11	2011	Taken together, these data demonstrate that VPO1 is a glycosylated heme peroxidase that is actively secreted into circulating plasma by vascular endothelial cells and shares several features with other members of the peroxidase-cyclooxygenase family, including the catalysis of dityrosine formation.	dityrosine	278-288	peroxidasin	Homo sapiens	44-48
23227203-0	2012	UV-light exposure of insulin: pharmaceutical implications upon covalent insulin dityrosine dimerization and disulphide bond photolysis.	dityrosine	80-90	insulin	Homo sapiens	21-28
23227203-0	2012	UV-light exposure of insulin: pharmaceutical implications upon covalent insulin dityrosine dimerization and disulphide bond photolysis.	dityrosine	80-90	insulin	Homo sapiens	72-79
23227203-3	2012	Absorbance, fluorescence emission and excitation data confirm dityrosine formation, leading to covalent insulin dimerization.	dityrosine	62-72	insulin	Homo sapiens	104-111
23227203-14	2012	Structural damage includes insulin dimerization via dityrosine cross-linking or disulphide bond disruption, which affects the hormone"s structure and bioactivity.	dityrosine	52-62	insulin	Homo sapiens	27-34
21963154-7	2011	Low levels of dityrosine cross-links were detected in copper/H2O2-treated IL-8 (CXCL8), which has one tyrosine residue, and none were detected in ENA-78 (CXCL5), which has none.	dityrosine	14-24	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
19779569-7	2009	Mutation of the active site serine of Osw3 results in spores with permeable walls, indicating that the catalytic activity of Osw3 is necessary for proper construction of the dityrosine layer.	dityrosine	174-184	Rrt12p	Saccharomyces cerevisiae S288C	38-42
19795928-5	2009	In addition to enzyme inactivation, AAPH treatment of purified CS resulted in dityrosine formation, increased protein surface hydrophobicity, and loss of tryptophan fluorescence.	dityrosine	78-88	citrate synthase	Homo sapiens	63-65
21162537-0	2011	Identification of the peroxidase-generated intermolecular dityrosine cross-link in bovine alpha-lactalbumin.	dityrosine	58-68	lactalbumin alpha	Bos taurus	90-107
20457484-0	2010	Structure and conformational studies on dityrosine formation in the DNA binding domain of RFX5.	dityrosine	40-50	regulatory factor X5	Homo sapiens	90-94
20457484-3	2010	We have examined the formation of intramolecular tyrosine cross linking, dityrosine, in RFX5DBD under oxidative stress, through UV irradiation and enzymatic action of H(2)O(2)/peroxidase by fluorescence spectroscopic studies.	dityrosine	73-83	regulatory factor X5	Homo sapiens	88-92
20457484-7	2010	The in vitro association of X-box DNA with RFX5DBD increased DT fluorescence significantly and protected RFX5DBD from UV irradiation as observed in SDS-PAGE followed by mass spectrometric analysis.	dityrosine	61-63	regulatory factor X5	Homo sapiens	43-47
19903699-5	2010	Dityrosine formation on oxidized fibrinogen were detected spectrophotometrically.	dityrosine	0-10	fibrinogen beta chain	Homo sapiens	33-43
19903699-9	2010	Formation of di-tyrosines in the amino acid side chains of fibrinogen were observed upon oxidation.	dityrosine	13-25	fibrinogen beta chain	Homo sapiens	59-69
19903699-10	2010	Decreased binding capacity of oxidized fibrinogen correlated with intensities of dityrosine formation.	dityrosine	81-91	fibrinogen beta chain	Homo sapiens	39-49
19928816-2	2009	Resilin binds to the cuticle polysaccharide chitin via a chitin binding domain and is further polymerized through oxidation of the tyrosine residues resulting in the formation of dityrosine bridges and assembly of a high-performance protein--carbohydrate composite material.	dityrosine	179-189	resilin	Drosophila melanogaster	0-7
19779569-7	2009	Mutation of the active site serine of Osw3 results in spores with permeable walls, indicating that the catalytic activity of Osw3 is necessary for proper construction of the dityrosine layer.	dityrosine	174-184	Rrt12p	Saccharomyces cerevisiae S288C	125-129
19779569-9	2009	OSW3 and other OSW genes identified in this screen are strong candidates to encode enzymes involved in assembly of this protective dityrosine coat.	dityrosine	131-141	Rrt12p	Saccharomyces cerevisiae S288C	0-4
17467041-3	2007	At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg.	dityrosine	115-125	fibrinogen beta chain	Homo sapiens	28-30
19147224-3	2009	Here we show that unmodified native fibrinogen can also be photochemically crosslinked into an elastic hydrogel biomaterial through the rapid formation of intermolecular dityrosine.	dityrosine	170-180	fibrinogen beta chain	Homo sapiens	36-46
18599641-8	2008	The structure of the high-affinity Cu(2+) binding site is consistent with the hypothesis that the redox activity of the metal ion bound to Abeta can lead to the formation of dityrosine-linked dimers found in AD.	dityrosine	174-184	amyloid beta precursor protein	Homo sapiens	139-144
18823586-7	2008	In addition, dityrosine crosslink formation was observed in acrolein-mediated NF-L aggregates and these aggregates displayed thioflavin T reactivity, reminiscent of amyloid.	dityrosine	13-23	neurofilament light chain	Homo sapiens	78-82
18620432-5	2008	Quercetin and the plasma metabolites inhibited the formation of dityrosine catalyzed by the MPO enzyme and HL-60 cells in a dose-dependent manner.	dityrosine	64-74	myeloperoxidase	Homo sapiens	92-95
18238775-2	2008	Studies have shown that oxidation and nitration of alpha-synuclein lead to the formation of stable dimers and oligomers through dityrosine cross-linking.	dityrosine	128-138	synuclein alpha	Homo sapiens	51-66
17297919-10	2007	Importantly, the formation of dityrosine crosslinked Abeta, by the oxidative modification of the peptide, only occurs at equimolar molar ratios and above.	dityrosine	30-40	amyloid beta precursor protein	Homo sapiens	53-58
17925093-8	2007	Superoxide dismutase + catalase and the HO* radical scavenger mannitol partially prevented inhibition of cytochrome c oxidase activity and formation of bityrosines.	dityrosine	152-163	catalase	Rattus norvegicus	23-31
19602568-3	2009	Monoclonal antibodies (mAbs) directed against the bityrosine motif Tyr-Tyr-Arg (YYR) specifically recognize PrP(Sc) and other misfolded PrP species.	dityrosine	50-60	prion protein	Mus musculus	108-111
19602568-3	2009	Monoclonal antibodies (mAbs) directed against the bityrosine motif Tyr-Tyr-Arg (YYR) specifically recognize PrP(Sc) and other misfolded PrP species.	dityrosine	50-60	prion protein	Mus musculus	136-139
19602568-4	2009	Here, we report that select bead-bound PrP-BCD mAbs induce exposure of bityrosine epitopes on mouse brain PrP.	dityrosine	71-81	prion protein	Mus musculus	39-42
19602568-4	2009	Here, we report that select bead-bound PrP-BCD mAbs induce exposure of bityrosine epitopes on mouse brain PrP.	dityrosine	71-81	prion protein	Mus musculus	106-109
19602568-5	2009	By competition immunoprecipitation, we show that PrP-BCD mAb-induced bityrosine exposure occurs at alpha-helices 1 and 3.	dityrosine	69-79	prion protein	Mus musculus	49-52
19521526-0	2009	SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.	dityrosine	34-44	solute carrier family 30 member 3	Rattus norvegicus	0-7
19521526-0	2009	SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.	dityrosine	34-44	solute carrier family 30 member 3	Rattus norvegicus	9-13
19521526-4	2009	Using mutagenized ZnT3 expressed in PC12 cells, we identified two critical tyrosine residues necessary for dityrosine-mediated ZnT3 oligomerization.	dityrosine	107-117	solute carrier family 30 member 3	Rattus norvegicus	18-22
19521526-4	2009	Using mutagenized ZnT3 expressed in PC12 cells, we identified two critical tyrosine residues necessary for dityrosine-mediated ZnT3 oligomerization.	dityrosine	107-117	solute carrier family 30 member 3	Rattus norvegicus	127-131
19272447-7	2009	The level of urinary PRL (21.6+/-10.6 micromol/mol of creatinine) significantly correlated with the other oxidative stress markers, 8-oxo-deoxyguanosine, dityrosine, and isoprostanes.	dityrosine	154-164	prolactin	Homo sapiens	21-24
19340621-0	2009	Detection of hydrogen peroxide by lactoperoxidase-mediated dityrosine formation.	dityrosine	59-69	lactoperoxidase	Homo sapiens	34-49
19340621-1	2009	The aim of this work was to study the dityrosine-forming activity of lactoperoxidase (LPO) and its potential application for measuring hydrogen peroxide (H2O2).	dityrosine	38-48	lactoperoxidase	Homo sapiens	69-84
19340621-1	2009	The aim of this work was to study the dityrosine-forming activity of lactoperoxidase (LPO) and its potential application for measuring hydrogen peroxide (H2O2).	dityrosine	38-48	lactoperoxidase	Homo sapiens	86-89
19340621-2	2009	It was observed that LPO was able to form dityrosine at low H2O2 concentrations.	dityrosine	42-52	lactoperoxidase	Homo sapiens	21-24
19340621-5	2009	It was concluded that LPO-mediated dityrosine formation offers a simple way for H2O2 measurement.	dityrosine	35-45	lactoperoxidase	Homo sapiens	22-25
18620432-4	2008	Immunohistochemical staining showed that a quercetin metabolite was colocalized with macrophages, MPO, and dityrosine, an MPO-derived oxidation product of tyrosine, in human atherosclerotic aorta.	dityrosine	107-117	myeloperoxidase	Homo sapiens	122-125
17255961-3	2007	Here, we report the differential effects of Sec24 isoform-specific silencing on the transport of the membrane reporter protein ERGIC-53 (ER-Golgi intermediate compartment-53) carrying the cytosolic ER export signals di-phenylalanine, di-tyrosine, di-leucine, di-isoleucine, di-valine or terminal valine.	dityrosine	234-245	SEC24 homolog B, COPII coat complex component	Homo sapiens	44-49
17255961-3	2007	Here, we report the differential effects of Sec24 isoform-specific silencing on the transport of the membrane reporter protein ERGIC-53 (ER-Golgi intermediate compartment-53) carrying the cytosolic ER export signals di-phenylalanine, di-tyrosine, di-leucine, di-isoleucine, di-valine or terminal valine.	dityrosine	234-245	lectin, mannose binding 1	Homo sapiens	127-135
17255961-3	2007	Here, we report the differential effects of Sec24 isoform-specific silencing on the transport of the membrane reporter protein ERGIC-53 (ER-Golgi intermediate compartment-53) carrying the cytosolic ER export signals di-phenylalanine, di-tyrosine, di-leucine, di-isoleucine, di-valine or terminal valine.	dityrosine	234-245	lectin, mannose binding 1	Homo sapiens	137-173
17467041-3	2007	At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg.	dityrosine	115-125	fibrinogen beta chain	Homo sapiens	163-165
17467041-3	2007	At the same molar ratios of Fg to PN, about 0.01, 0.19 and 0.34 of tyrosine residues per molecule were oxidized to dityrosine and the amount of carbonyl groups in Fg increased 1.3-, 2,3- and 3.6-fold when compared to control Fg.	dityrosine	115-125	fibrinogen beta chain	Homo sapiens	163-165
17467041-4	2007	SDS-PAGE analysis of PN-modified Fg suggests that inter- and intramolecular dityrosine cross-links occur between A alpha chains of Fg.	dityrosine	76-86	fibrinogen beta chain	Homo sapiens	33-35
17467041-4	2007	SDS-PAGE analysis of PN-modified Fg suggests that inter- and intramolecular dityrosine cross-links occur between A alpha chains of Fg.	dityrosine	76-86	fibrinogen beta chain	Homo sapiens	131-133
16983996-4	2006	The tyrosine amino-terminal residue of Leu-enkephalin is converted either to 3-nitrotyrosine thus producing nitroenkephalin and to dityrosine by dimerization with the production of an enkephalin dimer.	dityrosine	131-141	prodynorphin	Homo sapiens	39-53
17031260-8	2006	The treatment of hearts with NCX-4016 + Tempol showed significantly enhanced NO generation and decreased ROS and dityrosine (a marker of peroxynitrite) formation.	dityrosine	113-123	solute carrier family 8 member A1	Rattus norvegicus	29-32
16828704-9	2006	When GroEL was further incubated for the same time, but with increasing concentrations of H2O2 (>15 mM), the oxidation of GroEL"s cysteine residues and a significant decrease of the tyrosine fluorescence due to the formation of dityrosines were observed.	dityrosine	231-242	heat shock protein family D (Hsp60) member 1	Homo sapiens	5-10
16828704-9	2006	When GroEL was further incubated for the same time, but with increasing concentrations of H2O2 (>15 mM), the oxidation of GroEL"s cysteine residues and a significant decrease of the tyrosine fluorescence due to the formation of dityrosines were observed.	dityrosine	231-242	heat shock protein family D (Hsp60) member 1	Homo sapiens	125-130
17085975-3	2006	When cytochrome c was incubated with H2O2, oligomerization of the protein increased and the formation of carbonyl derivatives and dityrosine was stimulated.	dityrosine	130-140	cytochrome c, somatic	Homo sapiens	5-17
16194105-4	2005	The mass spectrometric, electron paramagnetic resonance, and separation studies of electrolyzed insulin solutions suggested that the loss of 4 mass units upon insulin oxidation at CNT could be accounted for by the formation of two dityrosine cross-links intramolecularly.	dityrosine	231-241	insulin	Homo sapiens	96-103
16298745-9	2005	Cu- and Mg-CHL showed radical scavenging ability as demonstrated by the diphenylpicrylhydracylradical (DPPH)-radical assay and estimation of phenoxyl radical generated diphenyl (dityrosine) formation.	dityrosine	178-188	chordin like 1	Homo sapiens	11-14
16500693-7	2006	The increased oxidative status in these mice was further confirmed by increased oxidatively modified proteins such as dityrosine formation and carbonylation in the cortex of SMP30 KO mice.	dityrosine	118-128	regucalcin	Mus musculus	174-179
16271394-5	2005	DFT also predicted that Abeta will cross-link via covalent dityrosine formation during the oxidation of ascorbate but not during the oxidation of cholesterol.	dityrosine	59-69	amyloid beta precursor protein	Homo sapiens	24-29
16194105-4	2005	The mass spectrometric, electron paramagnetic resonance, and separation studies of electrolyzed insulin solutions suggested that the loss of 4 mass units upon insulin oxidation at CNT could be accounted for by the formation of two dityrosine cross-links intramolecularly.	dityrosine	231-241	insulin	Homo sapiens	159-166
16195585-5	2005	We found that dityrosine cross-links in wheat-flour dough increased with the addition of peroxidase plus hydrogen peroxide.	dityrosine	14-24	peroxidase-like	Triticum aestivum	89-99
15979004-4	2005	Moreover, the mature form of the Pxd recombinant protein was specifically recognized by the anti-rAePO antibody as a 77 kDa band, while in the presence of H2O2 was able to convert tyrosine residues to di-tyrosine moieties.	dityrosine	201-212	Peroxidase	Drosophila melanogaster	33-36
16195585-0	2005	Effects of peroxidase and hydrogen peroxide on the dityrosine formation and the mixing characteristics of wheat-flour dough.	dityrosine	51-61	peroxidase-like	Triticum aestivum	11-21
16195585-3	2005	Formation of dityrosine increased with the addition of hydrogen peroxide, and hydrogen peroxide plus peroxidase, to wheat-flour dough, while the addition of peroxidase had no effect on the amount of dityrosine formed.	dityrosine	13-23	peroxidase-like	Triticum aestivum	101-111
15970567-1	2005	The formation of dityrosine of human insulin oxidized by metal-catalyzed oxidation system (H2O2/Cu) was estimated by fluorescent methods.	dityrosine	17-27	insulin	Homo sapiens	37-44
15970567-2	2005	The oxidation of tyrosine and phenylalanine residues present on the insulin molecule was evident after 2 minutes of in vitro oxidation due to the formation of protein-bound dityrosine.	dityrosine	173-183	insulin	Homo sapiens	68-75
15970567-9	2005	In conclusion, these observations show that dityrosine formation and other oxidative chemical changes of insulin due to its in vitro oxidation decrease and can abolish its biological activity.	dityrosine	44-54	insulin	Homo sapiens	105-112
15632155-6	2005	Peptides containing a dityrosine motif derived from the C-terminal tail inhibit RON in vitro or when delivered into intact cells, consistent with an autoinhibitory mechanism.	dityrosine	22-32	macrophage stimulating 1 receptor	Homo sapiens	80-83
15749393-2	2005	The present study demonstrates that the sperm whale myoglobin tyrosyl radical, formed by hydrogen peroxide-dependent self-peroxidation, can either react with another tyrosyl radical, resulting in a dityrosine cross-linkage, or react with the spin trap DMPO to form a diamagnetic nitrone adduct.	dityrosine	198-208	myoglobin	Physeter catodon	52-61
15632155-8	2005	Moreover, introduction of these Phe residues into the dityrosine motif of the RON kinase leads to a decrease in kinase activity.	dityrosine	54-64	macrophage stimulating 1 receptor	Homo sapiens	78-81
15777089-3	2005	The addition of HCO3- to aerobic incubations containing SOD1, Cys, and DTPA in phosphate buffer enhanced the peroxidase activity of SOD1, as measured by hydroxylation of cyclic nitrone spin traps, dichlorodihydrofluorescein oxidation to dichlorofluorescein, and oxidation of tyrosine to dityrosine.	dityrosine	287-297	superoxide dismutase 1	Homo sapiens	56-60
15777089-3	2005	The addition of HCO3- to aerobic incubations containing SOD1, Cys, and DTPA in phosphate buffer enhanced the peroxidase activity of SOD1, as measured by hydroxylation of cyclic nitrone spin traps, dichlorodihydrofluorescein oxidation to dichlorofluorescein, and oxidation of tyrosine to dityrosine.	dityrosine	287-297	superoxide dismutase 1	Homo sapiens	132-136
15470099-4	2004	In chs3 mutants, which lack the chitosan and dityrosine layers of the spore wall, bridges are absent.	dityrosine	45-55	chitin synthase CHS3	Saccharomyces cerevisiae S288C	3-7
15470107-12	2004	Finally, detailed analysis by electron microscopy of the spore walls in the crr1 mutants revealed a defect in the assembly of the spore wall components, suggesting a role for Crr1p in the cross-linking between the inner (glucan/mannoprotein) and the outer (chitosan/dityrosine) spore layers.	dityrosine	266-276	putative glycosylase	Saccharomyces cerevisiae S288C	76-80
15788232-5	2005	In addition, we were able to detect dityrosine that is a stable end MPO-oxidation product.	dityrosine	36-46	myeloperoxidase	Rattus norvegicus	68-71
15683253-0	2005	Site-specific nitration and oxidative dityrosine bridging of the tau protein by peroxynitrite: implications for Alzheimer"s disease.	dityrosine	38-48	microtubule associated protein tau	Homo sapiens	65-68
15470099-5	2004	By contrast, in dit1 mutants, which lack only the dityrosine layer, bridges are present, suggesting that the bridges may be composed of chitosan.	dityrosine	50-60	Dit1p	Saccharomyces cerevisiae S288C	16-20