PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset
12106018-2 1990 It also prevented the slowly developing increase in sensitivity of CA1 neurons to iontophoretically administered alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) which was seen in control slices that exhibit nondecremental LTP. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 113-169 carbonic anhydrase 1 Rattus norvegicus 67-70
12106018-2 1990 It also prevented the slowly developing increase in sensitivity of CA1 neurons to iontophoretically administered alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) which was seen in control slices that exhibit nondecremental LTP. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 171-175 carbonic anhydrase 1 Rattus norvegicus 67-70
34915397-7 2022 Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) are necessary to transmit auditory information to the PnC neurons and elicit the SR. AMPARs containing the glutamate AMPAR subunit 4 (GluA4) have fast kinetics, which makes them ideal candidates to transmit the SR signal. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-56 glutamate ionotropic receptor AMPA type subunit 4 Homo sapiens 68-73
34915397-7 2022 Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) are necessary to transmit auditory information to the PnC neurons and elicit the SR. AMPARs containing the glutamate AMPAR subunit 4 (GluA4) have fast kinetics, which makes them ideal candidates to transmit the SR signal. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-56 glutamate ionotropic receptor AMPA type subunit 4 Homo sapiens 160-166
34678444-5 2021 Abnormal miR-455-5p/CPEB1 pathway mediated cognitive deficits in APP/PS1 mice through suppressing alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor expressions. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 98-155 cytoplasmic polyadenylation element binding protein 1 Mus musculus 20-25
34678444-5 2021 Abnormal miR-455-5p/CPEB1 pathway mediated cognitive deficits in APP/PS1 mice through suppressing alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor expressions. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 98-155 presenilin 1 Mus musculus 69-72
34678444-5 2021 Abnormal miR-455-5p/CPEB1 pathway mediated cognitive deficits in APP/PS1 mice through suppressing alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor expressions. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 157-161 cytoplasmic polyadenylation element binding protein 1 Mus musculus 20-25
34678444-5 2021 Abnormal miR-455-5p/CPEB1 pathway mediated cognitive deficits in APP/PS1 mice through suppressing alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor expressions. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 157-161 presenilin 1 Mus musculus 69-72
34119623-6 2021 Optimal CB1R activity plays an essential neuroprotective role by providing a defense against the development of glutamate-mediated excitotoxicity, which is achieved, at least in part, by impeding AMPA-mediated increase in intracellular calcium overload and oxidative stress. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 196-200 cannabinoid receptor 1 Homo sapiens 8-12
34681616-3 2021 Specifically, the failure of A-to-I RNA editing at the glutamine/arginine (Q/R) site of the GluA2 subunit causes excessive permeability of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors to Ca2+, inducing fatal status epilepticus and the neurodegeneration of motor neurons in mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 139-196 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 92-97
34681616-3 2021 Specifically, the failure of A-to-I RNA editing at the glutamine/arginine (Q/R) site of the GluA2 subunit causes excessive permeability of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors to Ca2+, inducing fatal status epilepticus and the neurodegeneration of motor neurons in mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 198-202 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 92-97
34782594-1 2021 Dysfunction of the glutamate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunit and deficits in synaptic plasticity are implicated in schizophrenia and sleep and circadian rhythm disruption. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 29-85 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 102-107
34089730-1 2021 Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are the principal mediators of fast excitatory synaptic transmission and they are required for various forms of synaptic plasticity, including long-term potentiation (LTP) and depression (LTD), which are key mechanisms of learning and memory. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-56 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 68-74
34126141-9 2021 Levels of neuronal and synaptic maturation markers, namely, neural cell adhesion molecule 1 (NCAM1) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluR2, were strongly increased in 3D cultures. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 104-160 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 185-190
35465096-1 2022 Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at synapses is a predominant mechanism for regulating synaptic strength. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 14-70 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 104-110
35500677-1 2022 Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are key regulators during the process of synaptic plasticity in major depression disorder (MDD). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-57 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 69-75
35581601-0 2022 Fulminant anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluR1 antibodies encephalitis in a Chinese boy: a case report. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 15-71 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 81-86
35253937-5 2022 Hippocampal clusters of Kv1.1 voltage-gated potassium channels (VGKCs) and GluA1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) were quantified with confocal microscopy. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 92-148 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 75-80
35538302-6 2022 These effects are BDNF-dependent and require the recruitment of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors to allow the structural changes. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 64-120 brain derived neurotrophic factor Homo sapiens 18-22
35538302-6 2022 These effects are BDNF-dependent and require the recruitment of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors to allow the structural changes. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 122-126 brain derived neurotrophic factor Homo sapiens 18-22
35396579-4 2022 The associations of the NMDA (N-methyl-D-aspartate) receptor subunit GRIN2A and AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptor subunit GRIA3 provide support for dysfunction of the glutamatergic system as a mechanistic hypothesis in the pathogenesis of schizophrenia. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 86-143 glutamate ionotropic receptor AMPA type subunit 3 Homo sapiens 162-167
33862170-9 2021 Immunoblotting using hippocampal tissues demonstrated that amounts of PSD95, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor 2, and N-methyl-D-aspartate (NMDA) receptor 2B were significantly increased in the OVA group compared with the control group on P70, and a similar increasing trend for PSD95 was observed on P30. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 77-133 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 233-236
2696980-6 1989 The coinjection of gamma-glutamylaminomethylsulfonate (GAMS) with AMPA into the SI/LPO was found to inhibit the hypermotility response to AMPA at doses that were unable to produce a significant inhibition of the hypermotility responses to kainic acid or N-methyl-D-aspartic acid. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 66-70 lactoperoxidase Homo sapiens 83-86
2696980-7 1989 The injection of 6,7-dinitroquinoxaline-2,3-dione (DNQX) into the SI/LPO inhibited the hypermotility responses to AMPA or kainic acid while having no significant inhibitory effect on N-methyl-D-aspartic acid stimulated locomotor activity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 114-118 lactoperoxidase Homo sapiens 69-72
2570182-3 1989 The CA1 pyramidal cells were depolarized relative to their axons by superfusion with N-methyl-D-aspartate (NMDA), (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), kainate and L-glutamate. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 173-177 carbonic anhydrase 1 Rattus norvegicus 4-7
2859566-0 1985 The excitation of frog motoneurones in vitro by the glutamate analogue, DI-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), and the effect of amino acid antagonists. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 134-138 diaphanous related formin 2 Homo sapiens 72-80
6664465-5 1983 Quisqualate (QA), +/- alpha-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) and kainate (KA) exhibited potencies on CA1 cells similar to those reported for spinal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 79-83 carbonic anhydrase 1 Homo sapiens 125-128
35312684-2 2022 The synaptic membrane-associated guanylate kinase (MAGUK) scaffold protein membrane protein palmitoylated 2 (MPP2) is a component of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-associated protein complexes and also binds to the synaptic cell adhesion molecule SynCAM 1. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 133-189 MAGUK p55 scaffold protein 2 Homo sapiens 75-107
35312684-2 2022 The synaptic membrane-associated guanylate kinase (MAGUK) scaffold protein membrane protein palmitoylated 2 (MPP2) is a component of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-associated protein complexes and also binds to the synaptic cell adhesion molecule SynCAM 1. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 133-189 MAGUK p55 scaffold protein 2 Homo sapiens 109-113
34999197-2 2022 We present evidence that signaling at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) GluA1 receptor subunit contributes to increased blood pressure in a model of neurogenic hypertension induced by 14-day slow-pressor angiotensin II (AngII) infusion in male mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 42-98 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 254-259
34999197-2 2022 We present evidence that signaling at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) GluA1 receptor subunit contributes to increased blood pressure in a model of neurogenic hypertension induced by 14-day slow-pressor angiotensin II (AngII) infusion in male mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 100-104 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 238-252
34999197-2 2022 We present evidence that signaling at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) GluA1 receptor subunit contributes to increased blood pressure in a model of neurogenic hypertension induced by 14-day slow-pressor angiotensin II (AngII) infusion in male mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 100-104 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 254-259
2563916-4 1989 Kainic acid (AA3), quisqualic acid (AA2), and AMPA (AA2) resulted in dose-dependent reductions in all four neurochemical markers examined, while N-methyl-D,L-aspartate (AA1) and quinolinic acid (AA1) resulted in relative sparing of SLI and NPYLI. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 46-50 AA2 Homo sapiens 52-55
2563916-4 1989 Kainic acid (AA3), quisqualic acid (AA2), and AMPA (AA2) resulted in dose-dependent reductions in all four neurochemical markers examined, while N-methyl-D,L-aspartate (AA1) and quinolinic acid (AA1) resulted in relative sparing of SLI and NPYLI. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 46-50 AA1 Homo sapiens 169-172
2563916-4 1989 Kainic acid (AA3), quisqualic acid (AA2), and AMPA (AA2) resulted in dose-dependent reductions in all four neurochemical markers examined, while N-methyl-D,L-aspartate (AA1) and quinolinic acid (AA1) resulted in relative sparing of SLI and NPYLI. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 46-50 AA1 Homo sapiens 195-198
2563916-4 1989 Kainic acid (AA3), quisqualic acid (AA2), and AMPA (AA2) resulted in dose-dependent reductions in all four neurochemical markers examined, while N-methyl-D,L-aspartate (AA1) and quinolinic acid (AA1) resulted in relative sparing of SLI and NPYLI. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 46-50 SHC adaptor protein 2 Homo sapiens 232-235
34058285-5 2021 Consistent with the reduced NMDAR-dependent LTD, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) internalization was also weakened during NMDAR-dependent LTD in GluN2A TG mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 49-105 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 164-169
34058285-5 2021 Consistent with the reduced NMDAR-dependent LTD, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) internalization was also weakened during NMDAR-dependent LTD in GluN2A TG mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 49-105 glutamate receptor, ionotropic, NMDA2A (epsilon 1) Mus musculus 187-193
33450278-0 2021 The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 167-171 abhydrolase domain containing 6, acylglycerol lipase Rattus norvegicus 52-57
33751468-7 2021 Paired-pulse facilitation (PPF), a presynaptic phenomenon, was enhanced while the total and phosphorylated expression of NMDA-GluN1, NMDA-GluN2A, and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-GluA1 subunits were comparable between CA-treated and control groups. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 208-212 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 126-131
33649238-2 2021 At glutamatergic synapses on dendritic spines of principal cortical neurons, the maturation is largely governed by postsynaptic density protein-95 (PSD-95)-dependent synaptic incorporation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors into nascent AMPA-receptor silent synapses. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 250-254 discs large MAGUK scaffold protein 4 Mus musculus 115-146
33649238-2 2021 At glutamatergic synapses on dendritic spines of principal cortical neurons, the maturation is largely governed by postsynaptic density protein-95 (PSD-95)-dependent synaptic incorporation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors into nascent AMPA-receptor silent synapses. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 250-254 discs large MAGUK scaffold protein 4 Mus musculus 148-154
33693669-4 2021 We employed two mechanistically distinct LTD inhibitors, the Tat-GluA23Y peptide that blocks endocytosis of the GluA2-containing glutamate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), or the selective glutamate n-methyl-d-aspartate receptor (NMDAR) 2B antagonist, Ro25-6981, administered prior to the acquisition of two-way conditioned avoidance with or without tone pre-exposure. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 139-195 tyrosine aminotransferase Rattus norvegicus 61-64
33693669-4 2021 We employed two mechanistically distinct LTD inhibitors, the Tat-GluA23Y peptide that blocks endocytosis of the GluA2-containing glutamate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), or the selective glutamate n-methyl-d-aspartate receptor (NMDAR) 2B antagonist, Ro25-6981, administered prior to the acquisition of two-way conditioned avoidance with or without tone pre-exposure. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 139-195 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 65-70
33450278-0 2021 The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 167-171 monoglyceride lipase Rattus norvegicus 58-62
33538575-3 2021 We found that Abeta oligomers cause a rapid influx of calcium ions (Ca2+) across the cell membrane by rapidly activating extrasynaptic N-methyl-d-aspartate (NMDA) receptors and, to a lower extent, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 197-253 amyloid beta precursor protein Homo sapiens 14-19
33538575-3 2021 We found that Abeta oligomers cause a rapid influx of calcium ions (Ca2+) across the cell membrane by rapidly activating extrasynaptic N-methyl-d-aspartate (NMDA) receptors and, to a lower extent, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 255-259 amyloid beta precursor protein Homo sapiens 14-19
31988201-4 2021 Acute alcohol inhibits glutamatergic transmission via effects at N-methyl-d-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the CeA, whereas chronic alcohol up-regulates NMDA receptor (NMDAR)-mediated transmission. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 97-153 CEA cell adhesion molecule 3 Homo sapiens 178-181
32628930-2 2020 Cumulative evidence indicates that AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) play an important role in the treatment of depression. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 41-98 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 126-132
32017127-12 2021 B, binding of netrin-1 to DCC triggers further Ca2+ increases and activation of CaMKII, which results in postsynaptic insertion of GluA1-containing AMPA receptors and may increase the number or density of presynaptic glutamate vesicles. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 148-152 netrin 1 Homo sapiens 14-22
32017127-12 2021 B, binding of netrin-1 to DCC triggers further Ca2+ increases and activation of CaMKII, which results in postsynaptic insertion of GluA1-containing AMPA receptors and may increase the number or density of presynaptic glutamate vesicles. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 148-152 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 131-136
32543078-5 2021 The agonist AMPA provides a mixed population of compact and bulgy shapes of GluA2 not impacted by addition of GYKI53655. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 12-16 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 76-81
33221393-6 2021 Consistently, in hippocampal cultures from male and female neonatal mice, high glucose caused a RAGE-dependent reduction of AMPA- but not NMDA-evoked currents, and an increase in cytosolic reactive oxygen species (ROS). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 124-128 advanced glycosylation end product-specific receptor Mus musculus 96-100
32343420-4 2020 Whole-cell voltage clamp recordings on CA1 pyramidal neurons of organotypic slices show that 24 h after exposure to NMDA and DHPG preconditioning, AMPA induced-currents were significantly reduced. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 147-151 carbonic anhydrase 1 Rattus norvegicus 39-42
32343420-6 2020 Exposure of slices to the CB1 antagonist AM251 prevented the development of tolerance to AMPA toxicity induced by DHPG but not NMDA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 89-93 cannabinoid receptor 1 Rattus norvegicus 26-29
31926481-6 2020 Injection of the AMPA antagonist CNQX blocked the rescue of the behavioral phenotype by Reelin but did completely block the effects of Reelin on hippocampal neurogenesis. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 17-21 reelin Rattus norvegicus 88-94
32052226-2 2020 Activity-dependent ubiquitination of AMPA receptor (AMPAR) subunits sorts internalised receptors to late endosomes for degradation, which ultimately determines the number of AMPARs on neuronal membrane. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 37-41 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 174-180
32052226-5 2020 Here, we have shown that bicuculline induced GluA2 ubiquitination on the same lysine residues (Lys-870 and Lys-882) in the C-terminal as those elicited by the AMPA treatment. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 159-163 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 45-50
31926481-7 2020 Reelin is able to rescue the deficits in AMPA, NMDA, GABAA receptors, mTOR and p-mTOR induced by CORT. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 41-45 reelin Rattus norvegicus 0-6
31794026-7 2020 RESULTS: AMPA receptor subunits, GluA1 and GluA2, in the radicular neuropathic pain model were upregulated compared with those in the control group three days after surgery. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 9-13 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 43-48
32581155-3 2020 Here, we show that AMPA induces internalization of glutamate receptor 2/3 (GluR2/3), AMPA receptor subtype, in the mouse beta-cell line MIN6. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 19-23 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 51-73
32581155-3 2020 Here, we show that AMPA induces internalization of glutamate receptor 2/3 (GluR2/3), AMPA receptor subtype, in the mouse beta-cell line MIN6. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 19-23 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 75-82
31997814-5 2020 Additionally, we assessed the colocalization of astrocyte plasma membrane labeling with immunoreactivity for AMPA-(alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) glutamate receptor 1, an AMPA receptor subunit and established neuronal marker of excitatory synapses, as a metric of astrocyte-synapse proximity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 115-171 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 173-193
32417852-2 2020 We have previously reported that the administration of (R,S)-ketamine prevents stress-induced depressive-like behavior in male mice, perhaps by altering alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated transmission in hippocampal CA3. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 153-209 carbonic anhydrase 3 Mus musculus 264-267
32701951-2 2020 METHODS: We evaluated the age-dependency of the neuroprotective effect of an SK3 agonist, 1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one (1-EBIO), on Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) excitotoxicity to DN in ventral mesencephalon (VM) organotypic cultures. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 197-201 potassium calcium-activated channel subfamily N member 3 Homo sapiens 77-80
32701951-5 2020 Exposure of organotypic cultures to AMPA (100 mum, 16 h) had no effect on the survival of DN+ at DIV 8, but caused significant toxicity at DIV 15 (n = 15, p = 0.005) and DIV 22 (n = 15, p<0.001). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 36-40 latexin Homo sapiens 46-49
32701951-10 2020 At DIV 15, AMPA toxicity was prevented by exposure to 30 muM, but not 100 muM 1-EBIO. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 11-15 latexin Homo sapiens 57-60
31813315-13 2020 The results of present study suggest that leptin has hypophagic effect in neonatal chicken and this effect is probably mediated via NMDA and AMPA glutamatergic receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 141-145 leptin Gallus gallus 42-48
32376687-9 2020 Finally, we demonstrate that tamalin plays a critical role in mGluR-mediated internalization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, a process believed to be the cellular correlate for mGluR-dependent synaptic plasticity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 96-152 trafficking regulator and scaffold protein tamalin Mus musculus 29-36
31900023-8 2020 A 3-week ultrasound exposure increased scores of anxiety-like behaviors in the standard tests and altered hippocampal expression as well as internalization of AMPA receptor subunits GluA1-A3. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 159-163 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 182-187
31836174-7 2020 The pentraxin (PTX) domain of NPTX2 recruited GluA1-AMPA receptors and enhanced the extinction and excitatory synaptic transmission that was prevented by overexpressing carboxyl cytoplasmic tail of GluA1. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 52-56 neuronal pentraxin 2 Homo sapiens 30-35
31836174-7 2020 The pentraxin (PTX) domain of NPTX2 recruited GluA1-AMPA receptors and enhanced the extinction and excitatory synaptic transmission that was prevented by overexpressing carboxyl cytoplasmic tail of GluA1. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 52-56 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 46-51
31958346-2 2020 In the present study, we performed a comprehensive N-glycosylation analysis of mouse GluA1, one of major subunit of AMPA(alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate) type glutamate receptor, which possesses six potential N-glycosylation sites in the N-terminal domain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 116-175 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 85-90
32467647-3 2021 In light of the limited cognitive benefit of the direct antagonism of NMDA receptors in AD, we here focus on an alternative way to modify glutamatergic signaling through positive allosteric modulation of AMPA receptors, by the use of a PAM-AMPA compound. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 204-208 peptidylglycine alpha-amidating monooxygenase Homo sapiens 236-239
31563147-7 2020 A ~ 25% higher density of AMPA (Gria2) and NMDA (Grin1) mRNA expression was evident in PhMNs in the lower tertile compared to the upper tertile. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 26-30 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 32-37
31721013-0 2020 PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 74-78 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 88-93
31721013-5 2020 Our previous studies have found that M1 mAChRs could improve learning and memory through modulating AMPA receptor GluA1 subunit via PKA-PI3K-Akt signaling. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 100-104 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 114-119
31721013-5 2020 Our previous studies have found that M1 mAChRs could improve learning and memory through modulating AMPA receptor GluA1 subunit via PKA-PI3K-Akt signaling. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 100-104 AKT serine/threonine kinase 1 Homo sapiens 141-144
31952958-6 2020 Notably, phosphorylation by CaMKII and PKC regulates AMPA receptor trafficking and function in this site, is elevated following psychostimulant exposure, and is necessary for the expression of enhanced drug taking. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 53-57 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 28-34
31952958-7 2020 Increased FosB and decreased GLT1 levels are observed following psychostimulant exposure, are associated with increased drug taking and seeking, and are known to modulate AMPA receptors and extracellular glutamate levels respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 172-176 FosB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 11-15
31952958-7 2020 Increased FosB and decreased GLT1 levels are observed following psychostimulant exposure, are associated with increased drug taking and seeking, and are known to modulate AMPA receptors and extracellular glutamate levels respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 172-176 solute carrier family 1 member 2 Homo sapiens 30-34
31711126-7 2020 Interestingly, AMPA increased cGMP independently of NMDA receptors and dependent on NO synthase (NOS) activation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 15-19 nitric oxide synthase 1, neuronal Mus musculus 84-95
32268550-8 2020 The number of c-Fos-expressing neuronostatin neurons significantly increased following the AMPA and NMDA injections. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 91-95 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 14-19
32031699-0 2020 Toll-like Receptor 4 Signaling in Neurons Enhances Calcium-Permeable alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Currents and Drives Post-Traumatic Epileptogenesis. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 69-125 toll-like receptor 4 Rattus norvegicus 0-20
32031699-5 2020 RESULTS: The studies identify that TLR4 signaling in neurons augments dentate granule cell calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (CP-AMPAR) currents after brain injury. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 109-165 toll-like receptor 4 Rattus norvegicus 35-39
31935368-6 2020 Focusing on ultrastructural properties of the tripartite synapse in the CA1 region of hippocampus we found increased astrocyte ensheathment around both the presynaptic and postsynaptic elements, reduced synaptic AMPA receptor subunit and perisynaptic astrocyte GLT-1 expression, and increased number of docked vesicles at the presynaptic terminal. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 212-216 carbonic anhydrase 1 Rattus norvegicus 72-75
31916029-7 2020 Functional alterations in AMPA and NMDA receptors on CA1 pyramidal neurons of PNE mice were suggestive of higher GluA2-lacking and lower GluN2A-containing receptors, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 26-30 carbonic anhydrase 1 Mus musculus 53-56
31916029-7 2020 Functional alterations in AMPA and NMDA receptors on CA1 pyramidal neurons of PNE mice were suggestive of higher GluA2-lacking and lower GluN2A-containing receptors, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 26-30 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 113-118
32045742-5 2020 The acute pharmacological blockade of GLT-1 with dihydrokainate (DHK) in rat IL evoked an antidepressant-like effect mediated by local AMPA-R activation and a subsequent enhancement of serotonergic function. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 135-139 solute carrier family 1 member 2 Rattus norvegicus 38-43
32059758-6 2020 We show a polymorph-dependent differential synaptic redistribution of alpha3-Na+/K+-ATPase, GluA2 subunit containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, and GluN2B-subunit containing N-methyl-D-aspartate receptors, but not GluA1 subunit containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and metabotropic glutamate receptor 5 receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 280-336 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 92-97
32051325-1 2020 The AMPA receptor (AMPAR) subunit GluA3 has been suggested to shape synaptic transmission and activity-dependent plasticity in endbulb-bushy cell synapses (endbulb synapses) in the anteroventral cochlear nucleus, yet the specific roles of GluA3 in the synaptic transmission at endbulb synapses remains unexplored. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 4-8 glutamate receptor, ionotropic, AMPA3 (alpha 3) Mus musculus 34-39
32051325-1 2020 The AMPA receptor (AMPAR) subunit GluA3 has been suggested to shape synaptic transmission and activity-dependent plasticity in endbulb-bushy cell synapses (endbulb synapses) in the anteroventral cochlear nucleus, yet the specific roles of GluA3 in the synaptic transmission at endbulb synapses remains unexplored. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 4-8 glutamate receptor, ionotropic, AMPA3 (alpha 3) Mus musculus 239-244
32071234-0 2020 Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 32-36 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 54-59
31599924-0 2020 Stimulation of mGluR1/5 Improves Defective Internalization of AMPA Receptors in NPC1 Mutant Mouse. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 62-66 glutamate receptor, metabotropic 1 Mus musculus 15-21
31599924-0 2020 Stimulation of mGluR1/5 Improves Defective Internalization of AMPA Receptors in NPC1 Mutant Mouse. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 62-66 NPC intracellular cholesterol transporter 1 Mus musculus 80-84
31599924-2 2020 In this study, a defective basal and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-stimulated internalization of GluR2-containing AMPA receptors in NPC1-/- cortical neurons was detected. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 37-93 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 131-136
31599924-2 2020 In this study, a defective basal and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-stimulated internalization of GluR2-containing AMPA receptors in NPC1-/- cortical neurons was detected. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 37-93 NPC intracellular cholesterol transporter 1 Mus musculus 166-170
31599924-2 2020 In this study, a defective basal and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-stimulated internalization of GluR2-containing AMPA receptors in NPC1-/- cortical neurons was detected. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 95-99 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 131-136
31599924-2 2020 In this study, a defective basal and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-stimulated internalization of GluR2-containing AMPA receptors in NPC1-/- cortical neurons was detected. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 95-99 NPC intracellular cholesterol transporter 1 Mus musculus 166-170
31599924-2 2020 In this study, a defective basal and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-stimulated internalization of GluR2-containing AMPA receptors in NPC1-/- cortical neurons was detected. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 148-152 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 131-136
31599924-2 2020 In this study, a defective basal and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-stimulated internalization of GluR2-containing AMPA receptors in NPC1-/- cortical neurons was detected. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 148-152 NPC intracellular cholesterol transporter 1 Mus musculus 166-170
31599924-4 2020 Application of 3,5-dihydroxyphenylglycine (DHPG)-a mGluR1/5 agonist-and beta-CD markedly increases the internalization of AMPA receptors and decreases over-influx of calcium in NPC1-/- neurons, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 122-126 glutamate receptor, metabotropic 1 Mus musculus 51-57
31599924-4 2020 Application of 3,5-dihydroxyphenylglycine (DHPG)-a mGluR1/5 agonist-and beta-CD markedly increases the internalization of AMPA receptors and decreases over-influx of calcium in NPC1-/- neurons, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 122-126 beta-carotene oxygenase 1 Mus musculus 72-79
31599924-6 2020 Taken together, our data imply that abnormal internalization of AMPA receptors is a critical mechanism for neuronal dysfunction and the correction of dysfunctional mGluR1/5 is a potential therapeutic strategy for NPC1 disease. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 64-68 NPC intracellular cholesterol transporter 1 Mus musculus 213-217
30397978-2 2020 Previous work shows that a single dose of cocaine reduced the AMPA-to-NMDA ratio in Asic1a-/- mice, an effect observed after withdrawal in wild-type mice, whereas ASIC1A overexpression in the NAcore of rats decreases cocaine self-administration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 62-66 acid-sensing (proton-gated) ion channel 1 Mus musculus 84-90
32061032-7 2020 Meanwhile, upregulation of TRPV1 ameliorated the deficits of hippocampal CA1 long-term potentiation (LTP) and spatial learning and memory through inhibiting GluA2-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) endocytosis. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 174-230 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 27-32
32061032-7 2020 Meanwhile, upregulation of TRPV1 ameliorated the deficits of hippocampal CA1 long-term potentiation (LTP) and spatial learning and memory through inhibiting GluA2-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) endocytosis. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 174-230 carbonic anhydrase 1 Mus musculus 73-76
32061032-7 2020 Meanwhile, upregulation of TRPV1 ameliorated the deficits of hippocampal CA1 long-term potentiation (LTP) and spatial learning and memory through inhibiting GluA2-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) endocytosis. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 174-230 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 157-162
31814223-8 2020 Inhibition of ERK signaling specifically down-regulated the expression of calcium-permeable AMPAR subunits, GluA1 and GluA4, and up-regulated calcium-impermeable AMPAR subunit GluA2 implying differential regulation of the expression of calcium-permeable AMPA receptor subunits of glioblastoma. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 92-96 mitogen-activated protein kinase 1 Homo sapiens 14-17
31994358-0 2020 Upregulation of AMPA receptor GluA1 phosphorylation by blocking adenosine A1 receptors in the male rat forebrain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 16-20 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 30-35
31994358-6 2020 RESULTS: A systemic injection of the A1 antagonist DPCPX induced an increase in phosphorylation of AMPA receptor GluA1 subunits at a PKA-dependent site, serine 845 (S845), in the two subdivisions of the striatum, the caudate putamen, and nucleus accumbens. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 99-103 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 113-118
31994358-6 2020 RESULTS: A systemic injection of the A1 antagonist DPCPX induced an increase in phosphorylation of AMPA receptor GluA1 subunits at a PKA-dependent site, serine 845 (S845), in the two subdivisions of the striatum, the caudate putamen, and nucleus accumbens. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 99-103 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 133-136
31918976-6 2020 The aim of our study was to evaluate the differences in the expression of the GluA1, GluA2 subunits of AMPA receptors, pCREB and CREB in male and female mice exposed to maternal separation with early weaning (MSEW). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 103-107 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 85-90
32062370-4 2020 Our previous work also demonstrated increased expression of CA1 hippocampal long-term potentiation (LTP) and reduced desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type ionotropic glutamate receptors (AMPA-R) one week following a kainic acid induced seizure (KA-ELS). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 230-234 carbonic anhydrase 1 Rattus norvegicus 60-63
31376158-0 2020 NYX-2925 induces metabotropic N-methyl-d-aspartate receptor (NMDAR) signaling that enhances synaptic NMDAR and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 111-167 nyctalopin Rattus norvegicus 0-3
31376158-10 2020 Thus, NYX-2925 concentrations that increase synaptic GluN2B facilitated the chemical long-term potentiation induced insertion of synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA1 subunit levels. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 138-194 nyctalopin Rattus norvegicus 6-9
31376158-10 2020 Thus, NYX-2925 concentrations that increase synaptic GluN2B facilitated the chemical long-term potentiation induced insertion of synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA1 subunit levels. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 138-194 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 53-59
31376158-10 2020 Thus, NYX-2925 concentrations that increase synaptic GluN2B facilitated the chemical long-term potentiation induced insertion of synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA1 subunit levels. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 138-194 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 204-209
32076842-0 2020 Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 60-64 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 74-79
31805281-1 2020 Protein interacting with C kinase-1 (PICK1) regulates intra-cellular trafficking of GluA2-containing AMPA receptors, a process known to play a critical role in cocaine-seeking behavior. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 101-105 protein interacting with PRKCA 1 Rattus norvegicus 0-35
31805281-1 2020 Protein interacting with C kinase-1 (PICK1) regulates intra-cellular trafficking of GluA2-containing AMPA receptors, a process known to play a critical role in cocaine-seeking behavior. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 101-105 protein interacting with PRKCA 1 Rattus norvegicus 37-42
31805281-1 2020 Protein interacting with C kinase-1 (PICK1) regulates intra-cellular trafficking of GluA2-containing AMPA receptors, a process known to play a critical role in cocaine-seeking behavior. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 101-105 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 84-89
31937523-10 2020 Light-activation of the JNK inhibitor reduces AMPA receptor removal and spine regression in response to corticosterone and NMDA stress. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 46-50 mitogen-activated protein kinase 8 Rattus norvegicus 24-27
32076842-11 2020 The expression of AMPA receptor subunit GluR1 in olfactory bulb was associated with olfactory disorder. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 18-22 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 40-45
32029829-1 2020 PSD-95, via interactions with stargazin, anchors AMPA receptors at the synapse and regulates AMPAR currents. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 49-53 discs large MAGUK scaffold protein 4 Homo sapiens 0-6
32029829-1 2020 PSD-95, via interactions with stargazin, anchors AMPA receptors at the synapse and regulates AMPAR currents. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 49-53 calcium voltage-gated channel auxiliary subunit gamma 2 Homo sapiens 30-39
31637699-6 2020 ERalpha-induced LTP is NMDA receptor (NMDAR)-dependent and involves a postsynaptic expression mechanism that requires PI 3-kinase signalling and synaptic insertion of GluA2-lacking AMPA receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 181-185 estrogen receptor 1 Rattus norvegicus 0-7
31814223-0 2020 Transcriptional modulation of calcium-permeable AMPA receptor subunits in glioblastoma by MEK-ERK1/2 inhibitors and their role in invasion. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 48-52 mitogen-activated protein kinase kinase 7 Homo sapiens 90-93
31814223-0 2020 Transcriptional modulation of calcium-permeable AMPA receptor subunits in glioblastoma by MEK-ERK1/2 inhibitors and their role in invasion. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 48-52 mitogen-activated protein kinase 3 Homo sapiens 94-100
31814223-6 2020 Nonetheless, the association of ERK signaling with AMPA receptor subunits in glioblastoma is undetermined. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 51-55 mitogen-activated protein kinase 1 Homo sapiens 32-35
32014361-7 2020 Together, these findings suggest that associations between stargazin and AMPA subunits are abnormal, potentially affecting forward trafficking or synaptic stability of GluA1-containing AMPARs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 73-77 calcium voltage-gated channel auxiliary subunit gamma 2 Homo sapiens 59-68
32014361-7 2020 Together, these findings suggest that associations between stargazin and AMPA subunits are abnormal, potentially affecting forward trafficking or synaptic stability of GluA1-containing AMPARs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 73-77 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 168-173
32014361-7 2020 Together, these findings suggest that associations between stargazin and AMPA subunits are abnormal, potentially affecting forward trafficking or synaptic stability of GluA1-containing AMPARs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 73-77 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 185-191
32529990-1 2020 IQSEC2 is an X-linked gene highly expressed at the excitatory synapses where it plays a crucial role in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking and synaptic plasticity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 104-160 IQ motif and Sec7 domain ArfGEF 2 Homo sapiens 0-6
32014361-2 2020 AMPA receptors (AMPARs), a subtype of ionotropic glutamate receptor, are the main facilitators of fast, excitatory neurotransmission in the brain, and changes in AMPAR number or composition at synapses can regulate synaptic strength and plasticity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 16-22
31705923-0 2020 Spinal SNAP-25 regulates membrane trafficking of GluA1-containing AMPA receptors in spinal injury-induced neuropathic pain in rats. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 66-70 synaptosome associated protein 25 Rattus norvegicus 7-14
31705923-0 2020 Spinal SNAP-25 regulates membrane trafficking of GluA1-containing AMPA receptors in spinal injury-induced neuropathic pain in rats. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 66-70 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 49-54
31705923-3 2020 This study aimed to investigate whether and how SNAP-25 regulated AMPA receptors in neuropathic pain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 66-70 synaptosome associated protein 25 Rattus norvegicus 48-55
31705923-8 2020 An association between SNAP-25 and AMPA membrane trafficking was confirmed by SNAP-25 expression or phosphorylation inhibition. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 35-39 synaptosome associated protein 25 Rattus norvegicus 23-30
31705923-8 2020 An association between SNAP-25 and AMPA membrane trafficking was confirmed by SNAP-25 expression or phosphorylation inhibition. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 35-39 synaptosome associated protein 25 Rattus norvegicus 78-85
31705923-11 2020 SNAP-25 expression or phosphorylation inhibition alleviated neuropathic pain and downregulated membrane trafficking of AMPA receptors after SNL. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 119-123 synaptosome associated protein 25 Rattus norvegicus 0-7
31705923-12 2020 GluA1-containing AMPA receptor inhibition relieved mechanical allodynia and thermal hyperalgesia after SNL. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 17-21 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 0-5
31705923-13 2020 CONCLUSIONS: The upregulation of SNAP-25-dependent membrane trafficking of AMPA receptors via SNAP-25 phosphorylation at Ser187 contributed to SNL-induced neuropathic pain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 75-79 synaptosome associated protein 25 Rattus norvegicus 33-40
31705923-13 2020 CONCLUSIONS: The upregulation of SNAP-25-dependent membrane trafficking of AMPA receptors via SNAP-25 phosphorylation at Ser187 contributed to SNL-induced neuropathic pain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 75-79 synaptosome associated protein 25 Rattus norvegicus 94-101
31705923-15 2020 However, the mechanism of GluA1-containing AMPA receptor membrane trafficking mediated by SNAP-25 phosphorylation in neuropathic pain deserves further exploration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 43-47 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 26-31
31705923-15 2020 However, the mechanism of GluA1-containing AMPA receptor membrane trafficking mediated by SNAP-25 phosphorylation in neuropathic pain deserves further exploration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 43-47 synaptosome associated protein 25 Rattus norvegicus 90-97
31936514-2 2020 SOCE sensors, STIM1 and STIM2, can activate Orai, TRP channels and AMPA receptors, and inhibit voltage-gated channels in the plasma membrane. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 67-71 stromal interaction molecule 1 Rattus norvegicus 14-19
31936514-2 2020 SOCE sensors, STIM1 and STIM2, can activate Orai, TRP channels and AMPA receptors, and inhibit voltage-gated channels in the plasma membrane. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 67-71 stromal interaction molecule 2 Rattus norvegicus 24-29
31969804-7 2019 Phosphorylation levels of the AMPA-type glutamate receptor (AMPA-R) GluA2 subunit at Ser880 were prominently elevated in mice exposed to SD stress, indicating internalization of surface-expressed AMPA-Rs and decreased postsynaptic responsiveness. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 30-34 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 68-73
31969804-7 2019 Phosphorylation levels of the AMPA-type glutamate receptor (AMPA-R) GluA2 subunit at Ser880 were prominently elevated in mice exposed to SD stress, indicating internalization of surface-expressed AMPA-Rs and decreased postsynaptic responsiveness. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 60-64 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 68-73
31969804-7 2019 Phosphorylation levels of the AMPA-type glutamate receptor (AMPA-R) GluA2 subunit at Ser880 were prominently elevated in mice exposed to SD stress, indicating internalization of surface-expressed AMPA-Rs and decreased postsynaptic responsiveness. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 60-64 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 68-73
31646525-3 2020 Calcium influx into the postsynaptic neuron via: N-methyl-D-aspartate (NMDA) receptors activates small GTPase Rac1 and other Rac guanine nucleotide exchange factors, and stimulates calmodulin-dependent kinase kinase (CaMKK) and CaMKI; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors that are not impermeable to calcium ions, that is, those lacking the glutamate receptor-2 subunits, leads to activation of Ras guanine nucleotide-releasing factor proteins, which is coupled with activation of the mitogen-activated protein kinases/extracellular signal-regulated kinases signaling cascade; L-type voltage-gated calcium channels activates signaling pathways involving CaMKII, downstream responsive element antagonist modulator and distinct microdomains. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 235-291 calcium/calmodulin dependent protein kinase kinase 2 Homo sapiens 181-215
32013842-9 2020 Recent studies suggest a mechanistic model in which concurrent stimulation of D1 and GluA2-lacking AMPA receptors enables increased stimulus-induced trafficking of GluA1/GluA2 AMPARs into the postsynaptic density, thereby increasing the incentive effects of food, drugs, and associated cues. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 99-103 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 85-90
32013842-9 2020 Recent studies suggest a mechanistic model in which concurrent stimulation of D1 and GluA2-lacking AMPA receptors enables increased stimulus-induced trafficking of GluA1/GluA2 AMPARs into the postsynaptic density, thereby increasing the incentive effects of food, drugs, and associated cues. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 99-103 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 164-169
32013842-9 2020 Recent studies suggest a mechanistic model in which concurrent stimulation of D1 and GluA2-lacking AMPA receptors enables increased stimulus-induced trafficking of GluA1/GluA2 AMPARs into the postsynaptic density, thereby increasing the incentive effects of food, drugs, and associated cues. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 99-103 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 170-175
32586204-5 2020 LOQs for AMPA, glyphosate and glufosinate were established at 0.5, 0.2 and 0.3 mug L-1, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 9-13 TARBP2 subunit of RISC loading complex Homo sapiens 0-4
31759082-3 2020 Reports suggest that glutamate receptor AMPA type-2 subunit (GluA2) forms protein complex with GAPDH and internalized during excitotoxicity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 40-44 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 61-66
31759082-3 2020 Reports suggest that glutamate receptor AMPA type-2 subunit (GluA2) forms protein complex with GAPDH and internalized during excitotoxicity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 40-44 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 95-100
31759082-4 2020 Further, nuclear accumulation of GluA2 and GAPDH have been studied in neurological disorders like epilepsy and multiple sclerosis, and disruption of this complex rescued neurological symptoms such as astrogliosis, AMPA mediated excitotoxicity and p53 phosphorylation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 214-218 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 33-38
31759082-4 2020 Further, nuclear accumulation of GluA2 and GAPDH have been studied in neurological disorders like epilepsy and multiple sclerosis, and disruption of this complex rescued neurological symptoms such as astrogliosis, AMPA mediated excitotoxicity and p53 phosphorylation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 214-218 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 43-48
31759082-4 2020 Further, nuclear accumulation of GluA2 and GAPDH have been studied in neurological disorders like epilepsy and multiple sclerosis, and disruption of this complex rescued neurological symptoms such as astrogliosis, AMPA mediated excitotoxicity and p53 phosphorylation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 214-218 tumor protein p53 Homo sapiens 247-250
31939740-3 2020 For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young Syngap1+/- mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 50-54 discs large MAGUK scaffold protein 4 Mus musculus 26-32
31939740-3 2020 For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young Syngap1+/- mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 50-54 discs large MAGUK scaffold protein 4 Mus musculus 151-157
31939740-3 2020 For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young Syngap1+/- mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 50-54 synaptic Ras GTPase activating protein 1 homolog (rat) Mus musculus 182-189
31939740-3 2020 For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young Syngap1+/- mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 118-122 discs large MAGUK scaffold protein 4 Mus musculus 26-32
31939740-3 2020 For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young Syngap1+/- mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 118-122 discs large MAGUK scaffold protein 4 Mus musculus 151-157
31939740-3 2020 For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young Syngap1+/- mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 118-122 synaptic Ras GTPase activating protein 1 homolog (rat) Mus musculus 182-189
31836314-6 2020 We also hypothesize that in addition to DGKtheta"s presynaptic endocytic role, DGKtheta might also regulate the endocytosis of AMPA receptors and other postsynaptic membrane proteins. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 127-131 diacylglycerol kinase theta Homo sapiens 79-87
31675128-12 2020 INTERPRETATION: AMPA receptor plasticity mediated by the GluA1 subunit plays a critical role in sustaining and amplifying seizure activity and contributes to mortality. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 16-20 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 57-62
31757887-0 2019 A retention-release mechanism based on Rab11-FIP2 for AMPA receptor synaptic delivery during long-term potentiation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 54-58 RAB11a, member RAS oncogene family Rattus norvegicus 39-44
31757887-0 2019 A retention-release mechanism based on Rab11-FIP2 for AMPA receptor synaptic delivery during long-term potentiation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 54-58 optineurin Rattus norvegicus 45-49
31757887-1 2019 It is well established that Rab11-dependent recycling endosomes drive the activity-dependent delivery of AMPA receptors (AMPARs) into synapses during long-term potentiation (LTP). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 105-109 RAB11a, member RAS oncogene family Rattus norvegicus 28-33
31757887-1 2019 It is well established that Rab11-dependent recycling endosomes drive the activity-dependent delivery of AMPA receptors (AMPARs) into synapses during long-term potentiation (LTP). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 105-109 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 121-127
31582576-1 2019 The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) constitute a subclass of the ionotropic glutamate receptor superfamily, which functions as glutamate-gated cation channels to mediate the majority of excitatory neurotransmission in the central nervous system. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 4-60 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 72-78
31753031-9 2019 Taken together, our data suggest a new mechanism for dendritic transport of the AMPA receptor-PSD-95. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 80-84 discs large MAGUK scaffold protein 4 Homo sapiens 94-100
31597723-5 2019 We find that inhibition of Tiam1 function in dentate granule neurons reduces synaptic AMPA receptor function and causes dendritic spines to adopt an elongated filopodia-like morphology. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 86-90 TIAM Rac1 associated GEF 1 Rattus norvegicus 27-32
31604597-2 2019 Here, we delineate the assembly of AMPARs in the endoplasmic reticulum (ER) of native neurons as multi-state production line controlled by distinct interactome constituents: ABHD6 together with porcupine stabilizes pore-forming GluA monomers, and the intellectual-disability-related FRRS1l-CPT1c complexes promote GluA oligomerization and co-assembly of GluA tetramers with cornichon and transmembrane AMPA-regulatory proteins (TARP) to render receptor channels ready for ER exit. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 35-39 abhydrolase domain containing 6 Mus musculus 174-179
31604597-2 2019 Here, we delineate the assembly of AMPARs in the endoplasmic reticulum (ER) of native neurons as multi-state production line controlled by distinct interactome constituents: ABHD6 together with porcupine stabilizes pore-forming GluA monomers, and the intellectual-disability-related FRRS1l-CPT1c complexes promote GluA oligomerization and co-assembly of GluA tetramers with cornichon and transmembrane AMPA-regulatory proteins (TARP) to render receptor channels ready for ER exit. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 35-39 ferric-chelate reductase 1 like Mus musculus 283-289
31604597-2 2019 Here, we delineate the assembly of AMPARs in the endoplasmic reticulum (ER) of native neurons as multi-state production line controlled by distinct interactome constituents: ABHD6 together with porcupine stabilizes pore-forming GluA monomers, and the intellectual-disability-related FRRS1l-CPT1c complexes promote GluA oligomerization and co-assembly of GluA tetramers with cornichon and transmembrane AMPA-regulatory proteins (TARP) to render receptor channels ready for ER exit. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 35-39 carnitine palmitoyltransferase 1c Mus musculus 290-295
31609201-4 2019 The cAMP/PKA activities are restricted within the immediate vicinity of activated beta2AR, leading to selectively enhance PKA-dependent phosphorylation and stimulation of endogenous L-type calcium channel (LTCC) but not AMPA receptor in rat hippocampal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 220-224 adrenergic receptor, beta 2 Mus musculus 82-89
31722313-2 2019 ADAR2 regulates Ca2+ influx through alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors via adenosine-to-inosine conversion at the glutamine/arginine site of GluA2 mRNA, which makes ADAR2 a key factor in acquired Ca2+ resistance in motor neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 47-104 adenosine deaminase, RNA-specific, B1 Mus musculus 0-5
31722313-2 2019 ADAR2 regulates Ca2+ influx through alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors via adenosine-to-inosine conversion at the glutamine/arginine site of GluA2 mRNA, which makes ADAR2 a key factor in acquired Ca2+ resistance in motor neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 106-110 adenosine deaminase, RNA-specific, B1 Mus musculus 0-5
31722313-2 2019 ADAR2 regulates Ca2+ influx through alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors via adenosine-to-inosine conversion at the glutamine/arginine site of GluA2 mRNA, which makes ADAR2 a key factor in acquired Ca2+ resistance in motor neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 106-110 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 192-197
31722313-2 2019 ADAR2 regulates Ca2+ influx through alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors via adenosine-to-inosine conversion at the glutamine/arginine site of GluA2 mRNA, which makes ADAR2 a key factor in acquired Ca2+ resistance in motor neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 106-110 adenosine deaminase, RNA-specific, B1 Mus musculus 216-221
31546104-4 2019 Conditional knockout of Lgl1 in pyramidal neurons led to reduction of AMPA/NMDA ratio and impaired plasticity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 70-74 LLGL scribble cell polarity complex component 1 Homo sapiens 24-28
31647890-2 2019 (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 84-88 homer scaffold protein 1 Homo sapiens 38-45
31647890-2 2019 (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 84-88 glutamate receptor, ionotropic, kainate 1 Mus musculus 55-61
31629407-0 2019 Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 36-40 YY1 transcription factor Mus musculus 0-3
31629407-0 2019 Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 36-40 SUMO1/sentrin specific peptidase 1 Mus musculus 14-19
31629407-0 2019 Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 36-40 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 50-55
31629407-12 2019 Both Yy1 and Senp1 promote the expression of AMPA receptor subunit GluR1, a pivotal component in learning and memory. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 45-49 YY1 transcription factor Mus musculus 5-8
31629407-12 2019 Both Yy1 and Senp1 promote the expression of AMPA receptor subunit GluR1, a pivotal component in learning and memory. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 45-49 SUMO1/sentrin specific peptidase 1 Mus musculus 13-18
31629407-12 2019 Both Yy1 and Senp1 promote the expression of AMPA receptor subunit GluR1, a pivotal component in learning and memory. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 45-49 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 67-72
31772567-3 2019 Since neuronal pentraxin 2 (Nptx2) is a known regulator of AMPA receptor mobility and Nptx2 can be removed from the neuronal surface by PNN removal, we investigated whether Nptx2 has a function in the PNN. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 59-63 neuronal pentraxin 2 Homo sapiens 6-26
31772567-3 2019 Since neuronal pentraxin 2 (Nptx2) is a known regulator of AMPA receptor mobility and Nptx2 can be removed from the neuronal surface by PNN removal, we investigated whether Nptx2 has a function in the PNN. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 59-63 neuronal pentraxin 2 Homo sapiens 28-33
31636544-4 2019 By immunohistochemistry we showed immunoreactivity to the AMPA receptor subunits GluA1, GluA2 and GluA4 in OECs, suggesting the presence of AMPA receptors in OECs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 58-62 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 81-86
31636544-4 2019 By immunohistochemistry we showed immunoreactivity to the AMPA receptor subunits GluA1, GluA2 and GluA4 in OECs, suggesting the presence of AMPA receptors in OECs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 58-62 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 88-93
31636544-4 2019 By immunohistochemistry we showed immunoreactivity to the AMPA receptor subunits GluA1, GluA2 and GluA4 in OECs, suggesting the presence of AMPA receptors in OECs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 58-62 glutamate receptor, ionotropic, AMPA4 (alpha 4) Mus musculus 98-103
31636544-4 2019 By immunohistochemistry we showed immunoreactivity to the AMPA receptor subunits GluA1, GluA2 and GluA4 in OECs, suggesting the presence of AMPA receptors in OECs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 140-144 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 81-86
31636544-4 2019 By immunohistochemistry we showed immunoreactivity to the AMPA receptor subunits GluA1, GluA2 and GluA4 in OECs, suggesting the presence of AMPA receptors in OECs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 140-144 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 88-93
31636544-4 2019 By immunohistochemistry we showed immunoreactivity to the AMPA receptor subunits GluA1, GluA2 and GluA4 in OECs, suggesting the presence of AMPA receptors in OECs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 140-144 glutamate receptor, ionotropic, AMPA4 (alpha 4) Mus musculus 98-103
31679963-4 2019 Here, I summarize the discovery of semaphorin3A signaling endosomes, the first example other than neurotrophins to regulate dendritic development via AMPA receptor GluA2 localization in dendrites. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 150-154 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 164-169
31220556-4 2019 After DA lesion, extracellular signal-regulated kinase (ERK) activation was increased in response to DA D1 receptor (D1R) or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) stimulation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 125-181 mitogen-activated protein kinase 1 Mus musculus 17-54
31220556-4 2019 After DA lesion, extracellular signal-regulated kinase (ERK) activation was increased in response to DA D1 receptor (D1R) or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) stimulation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 125-181 mitogen-activated protein kinase 1 Mus musculus 56-59
31220556-4 2019 After DA lesion, extracellular signal-regulated kinase (ERK) activation was increased in response to DA D1 receptor (D1R) or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) stimulation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 183-187 mitogen-activated protein kinase 1 Mus musculus 17-54
31220556-4 2019 After DA lesion, extracellular signal-regulated kinase (ERK) activation was increased in response to DA D1 receptor (D1R) or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) stimulation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 183-187 mitogen-activated protein kinase 1 Mus musculus 56-59
31220556-4 2019 After DA lesion, extracellular signal-regulated kinase (ERK) activation was increased in response to DA D1 receptor (D1R) or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) stimulation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 183-187 dopamine receptor D1 Mus musculus 104-115
31768852-1 2019 It was shown previously that cycloprolylglycine, an endogenous neuropeptide, is a positive AMPA receptor modulator and is able to increase the content of BDNF in neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 91-95 pyroglutamylated RFamide peptide Rattus norvegicus 63-75
31541113-0 2019 Homomeric GluA2(R) AMPA receptors can conduct when desensitized. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 19-23 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 10-15
31541113-2 2019 AMPA-type glutamate receptors (AMPARs), which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 31-37
31108504-5 2019 Basal intracellular calcium levels and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-induced signal amplitudes were elevated in mutant TDP43 MNs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 97-101 TAR DNA binding protein Homo sapiens 153-158
31564120-3 2019 The role of NMDAR activation on invasion of glioblastoma cells and the crosstalk with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is yet to be explored. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 86-142 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 154-160
31358853-4 2019 This effect was accompanied by increased phosphorylation and surface expression of glutamate A1 (GluA1) -containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 116-172 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 83-95
31366130-3 2019 IFNgamma and TNFalpha increased basal, adenophostin-A (AdA)-evoked, and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA)-evoked astroglial L-glutamate releases. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 132-136 interferon gamma Homo sapiens 0-8
31366130-3 2019 IFNgamma and TNFalpha increased basal, adenophostin-A (AdA)-evoked, and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA)-evoked astroglial L-glutamate releases. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 132-136 tumor necrosis factor Homo sapiens 13-21
31358853-4 2019 This effect was accompanied by increased phosphorylation and surface expression of glutamate A1 (GluA1) -containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 116-172 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 97-102
31092554-7 2019 Furthermore, glutamate-induced up-regulation of glutamate ionotropic receptor alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type subunit 2 (GRIA2) in neurons depended on FUS expression, consistent with a functional role for FUS in excitotoxic stress. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 136-140 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 158-163
31092554-7 2019 Furthermore, glutamate-induced up-regulation of glutamate ionotropic receptor alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type subunit 2 (GRIA2) in neurons depended on FUS expression, consistent with a functional role for FUS in excitotoxic stress. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 136-140 FUS RNA binding protein Homo sapiens 188-191
31092554-7 2019 Furthermore, glutamate-induced up-regulation of glutamate ionotropic receptor alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type subunit 2 (GRIA2) in neurons depended on FUS expression, consistent with a functional role for FUS in excitotoxic stress. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 136-140 FUS RNA binding protein Homo sapiens 242-245
30176255-6 2018 The evidence that AMPA-induced intracellular Zn2+ dysregulation causes movement disorder via nigrostriatal dopaminergic neurodegeneration suggests that AMPA receptors, probably Ca2+- and Zn2+-permeable GluR2-lacking AMPA receptors are potential targets for overcoming Parkinson"s syndrome. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 18-22 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 202-207
31036551-5 2019 TDP-43A315T over-expression increased the total levels of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropinionic acid (AMPA) glutamate receptor subunit GluR1, yet the localization of GluR1 to the dendritic spine was reduced. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 122-126 TAR DNA binding protein Homo sapiens 0-6
31036551-5 2019 TDP-43A315T over-expression increased the total levels of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropinionic acid (AMPA) glutamate receptor subunit GluR1, yet the localization of GluR1 to the dendritic spine was reduced. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 122-126 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 155-160
31036551-5 2019 TDP-43A315T over-expression increased the total levels of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropinionic acid (AMPA) glutamate receptor subunit GluR1, yet the localization of GluR1 to the dendritic spine was reduced. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 122-126 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 186-191
29293918-3 2019 Electrophysiologically this correlates with cell-autonomous reductions in both AMPA- and NMDA-excitatory postsynaptic currents in individual hippocampal neurons from which Sestd1 has been deleted in vivo. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 79-83 SEC14 and spectrin domains 1 Mus musculus 172-178
30705620-6 2018 Here, we show that neurons with multiple primary dendrites that reside in the outer GCL of Fmr1 KO mice display significantly smaller NMDAR excitatory post-synaptic currents (EPSCs) and a higher alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) to NMDA ratio in comparison to their wild-type counterparts. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 253-257 germ cell-less, spermatogenesis associated 1 Mus musculus 84-87
30705620-6 2018 Here, we show that neurons with multiple primary dendrites that reside in the outer GCL of Fmr1 KO mice display significantly smaller NMDAR excitatory post-synaptic currents (EPSCs) and a higher alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) to NMDA ratio in comparison to their wild-type counterparts. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 253-257 fragile X messenger ribonucleoprotein 1 Mus musculus 91-95
30705620-8 2018 In contrast, although neurons with a single primary dendrite resided in the inner GCL of Fmr1 KO mice had a trend toward a reduction in NMDAR EPSCs and a higher AMPA/NMDA ratio, no alterations were found in dendritic complexity at this developmental stage. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 161-165 fragile X messenger ribonucleoprotein 1 Mus musculus 89-93
31234416-8 2019 Activated ARF6 promotes downregulation of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors through a c-jun N terminal kinase (JNK)-mediated pathway. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 50-106 ADP-ribosylation factor 6 Mus musculus 10-14
31234416-8 2019 Activated ARF6 promotes downregulation of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors through a c-jun N terminal kinase (JNK)-mediated pathway. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 50-106 mitogen-activated protein kinase 8 Mus musculus 149-172
31234416-8 2019 Activated ARF6 promotes downregulation of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors through a c-jun N terminal kinase (JNK)-mediated pathway. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 50-106 mitogen-activated protein kinase 8 Mus musculus 174-177
32440593-6 2019 These effects were mediated by the activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that triggered the pathways of mammalian target of rapamycin and extracellular signal-regulated kinase via the engagement of brain-derived neurotrophic factor signaling, as previously described in rodent prefrontal cortex. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 49-105 mechanistic target of rapamycin kinase Homo sapiens 146-175
32440593-6 2019 These effects were mediated by the activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that triggered the pathways of mammalian target of rapamycin and extracellular signal-regulated kinase via the engagement of brain-derived neurotrophic factor signaling, as previously described in rodent prefrontal cortex. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 49-105 brain derived neurotrophic factor Homo sapiens 240-273
31658055-6 2019 Furthermore, in these mice, we observed a decrease in the AMPA receptor subunit GluA1 and they had impaired long-term potentiation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 58-62 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 80-85
29764453-12 2018 Evoked AMPA-R activity, however, decreases Abeta levels by both stimulating glutamatergic transmission and activating downstream NMDA receptor (NMDA-R) signaling and, with extended AMPA treatment, acting independently of NMDA-Rs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 7-11 amyloid beta (A4) precursor protein Mus musculus 43-48
30006682-12 2018 Our results indicate that CGA exhibits a protective potential via antioxidant and apoptosis caspases and calpains dependent against AMPA-mediated excitotoxicity, and these finding indicate that CGA is able to be a good candidate for preventive approach for neurodegenerative disorders associated with loss and damage in oligodendrocytes and AMPA-mediated excitotoxicity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 132-136 caspase 1 Homo sapiens 92-100
32002960-10 2018 As to AMPA receptors, a heterocomplex was found for the interaction between IFNgR1 and the AMPAR mediated via the subunit GluA1 which may be of relevance for neuroinflammation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 6-10 interferon gamma receptor 1 Homo sapiens 76-82
32002960-10 2018 As to AMPA receptors, a heterocomplex was found for the interaction between IFNgR1 and the AMPAR mediated via the subunit GluA1 which may be of relevance for neuroinflammation. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 6-10 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 122-127
30023428-6 2018 Minimal stimulation experiments reveal that Shank2 Deltaex7-/- mice possess an excessive fraction of silent (i.e., alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, short, AMPA receptor lacking) synapses. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 115-171 SH3 and multiple ankyrin repeat domains 2 Mus musculus 44-50
29874582-6 2018 Syntaxin 4 knockout (KO) caused drastic reduction in expression of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-d-aspartic acid (NMDA) receptors in cultured hippocampal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 133-137 syntaxin 4A (placental) Mus musculus 0-10
27766534-3 2017 Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate channels are assembled from GluA1-4 AMPA or GluK1-5 kainate receptor subunits. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 52-56 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 98-103
29378298-4 2018 Furthermore, because predicted miR-34a target genes were broadly linked to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-d-aspartate (NMDA) receptors, we evaluated synaptic plasticity by investigating high-frequency conditioning tetanus-induced excitatory postsynaptic potential, which revealed that synaptic plasticity was promoted in miR-34a knockout/APP/PS1 mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 133-137 microRNA 34a Mus musculus 31-38
29378298-4 2018 Furthermore, because predicted miR-34a target genes were broadly linked to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-d-aspartate (NMDA) receptors, we evaluated synaptic plasticity by investigating high-frequency conditioning tetanus-induced excitatory postsynaptic potential, which revealed that synaptic plasticity was promoted in miR-34a knockout/APP/PS1 mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 133-137 microRNA 34a Mus musculus 367-374
29378298-4 2018 Furthermore, because predicted miR-34a target genes were broadly linked to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-d-aspartate (NMDA) receptors, we evaluated synaptic plasticity by investigating high-frequency conditioning tetanus-induced excitatory postsynaptic potential, which revealed that synaptic plasticity was promoted in miR-34a knockout/APP/PS1 mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 133-137 presenilin 1 Mus musculus 388-391
28377502-0 2017 GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 75-131 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 0-5
28673833-3 2017 Additionally, a relation between glutamate neurotransmission and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainite (AMPA/KA) and metabotropic mGluR5 receptors is well established. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 65-121 glutamate receptor, ionotropic, kainate 1 Mus musculus 157-163
28809097-4 2017 The magnitude of changes in Ras BRaf binding force correlates with the size of alterations in protein affinity and in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate receptor (-R)-mediated synaptic transmission in neurons expressing replacement BRaf mutants, and predicts the extent of learning impairments in animals expressing replacement BRaf mutants. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 176-180 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 32-36
28809097-4 2017 The magnitude of changes in Ras BRaf binding force correlates with the size of alterations in protein affinity and in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate receptor (-R)-mediated synaptic transmission in neurons expressing replacement BRaf mutants, and predicts the extent of learning impairments in animals expressing replacement BRaf mutants. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 176-180 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 281-285
28809097-4 2017 The magnitude of changes in Ras BRaf binding force correlates with the size of alterations in protein affinity and in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-sensitive glutamate receptor (-R)-mediated synaptic transmission in neurons expressing replacement BRaf mutants, and predicts the extent of learning impairments in animals expressing replacement BRaf mutants. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 176-180 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 281-285
28912687-6 2017 On the first day, we found a transient increase in a ratio of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl d-aspartate (NMDA) receptors in the excitatory synaptic response in pyramidal neurons of the CA1 area of the dorsal hippocampus, but not in the TC. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 120-124 carbonic anhydrase 1 Rattus norvegicus 232-235
28100749-11 2017 Superfusing spinal cord slices with CXCL10 enhanced spontaneous EPSCs and potentiated NMDA-induced and AMPA-induced currents of lamina II neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 103-107 chemokine (C-X-C motif) ligand 10 Mus musculus 36-42
26232640-2 2017 A previously unappreciated mechanism of action of GPR35 has emerged as a Galphai/o-coupled inhibitor of synaptic transmission, a finding that has significant implications for the accepted role of kynurenic acid as a broad-spectrum antagonist of the NMDA, AMPA/kainite and alpha7 nicotinic receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 255-259 G protein-coupled receptor 35 Homo sapiens 50-55
28160291-9 2017 Whole-cell patch recording from RGCs further showed that TBN slightly but significantly inhibited L-type calcium channels, but had little effect on T-type calcium channel or NMDA-, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)-induced current. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 238-242 TATA-box binding protein associated factor 8 Rattus norvegicus 57-60
27417577-2 2016 In rodents SWM requires an intact hippocampus and SWM expression is impaired in mice lacking the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 (Gria1-/- mice). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 97-153 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 178-183
27639291-2 2016 During the early postnatal development, very low/low frequency (0.033-1Hz) activation of previously non-stimulated (naive) SC synapses (SR-CA1 synapses) results in a stimulus-, but not frequency-, dependent depression which is explained by postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) silencing. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 311-315 carbonic anhydrase 1 Rattus norvegicus 139-142
27417577-2 2016 In rodents SWM requires an intact hippocampus and SWM expression is impaired in mice lacking the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 (Gria1-/- mice). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 97-153 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 185-190
27320208-6 2016 Caspase 3 cleavage was observed since the first day of AMPA infusion. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 55-59 caspase 3 Homo sapiens 0-9
27240164-9 2016 Furthermore, AMPA/NMDA ratio was significantly decreased in the Abeta treated animals. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 13-17 amyloid beta precursor protein Rattus norvegicus 64-69
26944112-6 2016 CM from AS treated with ACTH protected OL from glutamate, NMDA, AMPA, quinolinic acid and ROS but not from kainate, staurosporine, NO or kynurenic acid. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 64-68 proopiomelanocortin Homo sapiens 24-28
25662825-3 2016 Compared with wildtype, pyramidal neurons in the Mecp2 null mPFC exhibit significant reductions in excitatory postsynaptic currents, the duration of excitatory UP-states, evoked population activity, and the ratio of NMDA:AMPA currents, as well as an increase in the relative fraction of NR2B currents. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 221-225 methyl CpG binding protein 2 Mus musculus 49-54
25662825-3 2016 Compared with wildtype, pyramidal neurons in the Mecp2 null mPFC exhibit significant reductions in excitatory postsynaptic currents, the duration of excitatory UP-states, evoked population activity, and the ratio of NMDA:AMPA currents, as well as an increase in the relative fraction of NR2B currents. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 221-225 complement factor properdin Mus musculus 60-64
25660027-3 2015 Here, we report that all four AMPAR subunits (GluA1-4) are rapidly ubiquitinated upon brief application of AMPA or bicuculline in cultured neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 30-34 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 46-53
26311781-7 2015 AMPA receptor stimulation of wild-type OPCs caused decreased cell-surface expression of the GluR2 AMPA receptor subunit and increased intracellular Ca(2+) signaling, whereas PLP null OPCs did not reduce GluR2 at the cell surface or increase Ca(2+) signaling in response to AMPA treatment. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 92-97
25656479-2 2015 Using patch-clamp recordings and calcium imaging in rat isolated retinal cells, we demonstrated that orexin-A suppressed alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)-preferring receptor-mediated currents (AMPA-preferring currents) in ganglion cells (GCs) through OX1R, but potentiated those in amacrine cells (ACs) through OX2R. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 180-184 hypocretin neuropeptide precursor Rattus norvegicus 101-109
25656479-2 2015 Using patch-clamp recordings and calcium imaging in rat isolated retinal cells, we demonstrated that orexin-A suppressed alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)-preferring receptor-mediated currents (AMPA-preferring currents) in ganglion cells (GCs) through OX1R, but potentiated those in amacrine cells (ACs) through OX2R. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 180-184 hypocretin receptor 1 Rattus norvegicus 283-287
25656479-2 2015 Using patch-clamp recordings and calcium imaging in rat isolated retinal cells, we demonstrated that orexin-A suppressed alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)-preferring receptor-mediated currents (AMPA-preferring currents) in ganglion cells (GCs) through OX1R, but potentiated those in amacrine cells (ACs) through OX2R. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 180-184 hypocretin receptor 2 Rattus norvegicus 343-347
25933983-5 2015 The mechanisms involving NMDA and AMPA glutamate, 5-HT1A serotonin and the GPR39 zinc-sensing receptor and intracellular pathways will be discussed. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 34-38 G protein-coupled receptor 39 Homo sapiens 75-80
24345054-7 2014 The readily releasable pool and vesicular release probability of synaptic vesicles are both altered in neurons over-expressing Seipin-N88S, whereas neither gamma-amino butyric acid (GABA) nor alpha-Amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) induced whole cell currents are affected. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 251-255 BSCL2 lipid droplet biogenesis associated, seipin Homo sapiens 127-133
24130267-2 2015 Activation of kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 31-87 interleukin 6 Homo sapiens 132-145
24130267-2 2015 Activation of kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 31-87 interleukin 6 Homo sapiens 147-151
25069643-2 2014 alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate receptor (NMDA) glutamate receptors (AMPARs/NMDARs) are the predominant receptors in neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-56 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 126-132
24726558-4 2014 We investigated the effects of four representative local anesthetics, lidocaine, tetracaine, levobupivacaine, and ropivacaine on ERK phosphorylation induced by capsaicin, which releases glutamate from presynaptic neurons, NMDA, AMPA, or ionomycin, a calcium ionophore, in dorsal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 228-232 Eph receptor B1 Rattus norvegicus 129-132
24421411-4 2014 Shank proteins are associated with N-methyl-d-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor loss at the PSD in AD; mutations in Shank also lead to autism spectrum disorders (ASDs) and schizophrenia, both of which affect cognition, suggesting that Shank may play a common pathologic role in AD, ASD, and schizophrenia. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 60-116 SH3 and multiple ankyrin repeat domains 2 Homo sapiens 0-5
24423643-12 2014 Conversely, a 48-hour ET-1 treatment increased MN cell death induced by acute exposure to AMPA (50muM), which is indicative of two distinct pathways leading to neuronal death. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 90-94 endothelin 1 Rattus norvegicus 22-26
23621888-3 2013 FINDINGS: We observed that daily intraperitoneal injections of human insulin-like growth factor 1 (IGF-1) over a 2-week period reversed deficits in hippocampal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) signaling, long-term potentiation (LTP), and motor performance that we had previously reported in Shank3-deficient mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 218-222 insulin like growth factor 1 Homo sapiens 69-97
24077066-6 2014 Increased alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/N-methyl-D-aspartate ratio and rectification of AMPA receptor responses even at 6 days after GAN administration suggested persistent synaptic targeting of GluA2-lacking AMPA receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 69-73 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 230-235
23962648-4 2013 Intra-VTA infusion of the iGluR agonists (+-)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA; 1 mug/mul) or N-methyl-d-aspartic acid (NMDA; 2 mug/mul) enhanced basal NAc dopamine efflux. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 41-103 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 105-112
23621888-3 2013 FINDINGS: We observed that daily intraperitoneal injections of human insulin-like growth factor 1 (IGF-1) over a 2-week period reversed deficits in hippocampal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) signaling, long-term potentiation (LTP), and motor performance that we had previously reported in Shank3-deficient mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 218-222 insulin like growth factor 1 Homo sapiens 99-104
23537341-4 2013 RESULTS: AMPA- and NMDA-induced currents were increased in peak amplitude by IL-1beta in a manner different from each other in SG neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 9-13 interleukin 1 beta Rattus norvegicus 77-85
23036017-4 2013 Hence synapse targeting of Abeta oligomers involves activation of many receptors such as N-Methyl-D-aspartate (NMDA), alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), nicotinic acetylcholine (nAChRs), p75 neurotrophin (p75NTR) following aberrant clustering of metabotropic glutamate receptors (mGluR5) leading to neuronal loss and LTP failure. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 118-175 amyloid beta precursor protein Homo sapiens 27-32
23537341-7 2013 Minocycline, a microglia inhibitor, blocked the facilitatory effect of IL-1beta on AMPA- but not NMDA-induced currents, where minocycline itself depressed NMDA- but had not any effects on AMPA-induced currents. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 83-87 interleukin 1 beta Rattus norvegicus 71-79
23036017-4 2013 Hence synapse targeting of Abeta oligomers involves activation of many receptors such as N-Methyl-D-aspartate (NMDA), alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), nicotinic acetylcholine (nAChRs), p75 neurotrophin (p75NTR) following aberrant clustering of metabotropic glutamate receptors (mGluR5) leading to neuronal loss and LTP failure. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 177-181 amyloid beta precursor protein Homo sapiens 27-32
22992730-12 2012 Additionally, AMPA-induced apoptotic retinal cell death was regulated by both NOS and Src activity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 14-18 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 86-89
23525449-10 2013 AMPA (50 mumol/L) induced NP1 and significant cell death in WT but not in NP1-/- neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 neuronal pentraxin 1 Homo sapiens 26-29
23173741-6 2013 Furthermore, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced whole-cell currents were significantly reduced in Seipin KD neurons, which could be rescued by expression of a shRNA-resistant human Seipin. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 13-69 BSCL2 lipid droplet biogenesis associated, seipin Homo sapiens 135-141
23173741-6 2013 Furthermore, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced whole-cell currents were significantly reduced in Seipin KD neurons, which could be rescued by expression of a shRNA-resistant human Seipin. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 13-69 BSCL2 lipid droplet biogenesis associated, seipin Homo sapiens 218-224
23173741-6 2013 Furthermore, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced whole-cell currents were significantly reduced in Seipin KD neurons, which could be rescued by expression of a shRNA-resistant human Seipin. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 71-75 BSCL2 lipid droplet biogenesis associated, seipin Homo sapiens 135-141
23173741-6 2013 Furthermore, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced whole-cell currents were significantly reduced in Seipin KD neurons, which could be rescued by expression of a shRNA-resistant human Seipin. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 71-75 BSCL2 lipid droplet biogenesis associated, seipin Homo sapiens 218-224
22683643-4 2012 Previous studies demonstrated that acute attenuation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptor activity by the non-competitive AMPA antagonist, EGIS-8332, in both 1- and 6-7-month-old Cln3(Deltaex1-6) mice results in improvement in motor coordination. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 110-114 ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) Mus musculus 229-233
22771975-3 2012 Entrapping pep2-SVKI, a peptide known to compete for the binding of GluA2 subunit to scaffolding proteins involved in AMPA receptor endocytosis, in NAC synaptosomes prevented the nicotine-induced reduction of AMPA-mediated [3H]DA exocytosis, while pep2-SVKE, used as negative control, was inefficacious. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 118-122 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 68-73
22750206-4 2012 NMDA/AMPA current ratios were lower in Fmr1-KO mice than in WT mice, at ages ranging from 3-18months. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 5-9 fragile X messenger ribonucleoprotein 1 Mus musculus 39-43
20409611-2 2012 Excitotoxic motor neuron death is mediated through the Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type of glutamate receptors and Ca(2+) permeability is determined by the GluR2 subunit. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 72-129 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 210-215
21538661-8 2012 8-OH DPAT also modulated the current evoked by exogenously applied AMPA, inducing either a reduction or an increase of amplitude in distinct neurons; these effects were respectively blocked by 5-HT(1A) and 5-HT(7) receptor antagonists, indicating that both receptors exert a postsynaptic action. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 67-71 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 193-200
22226778-2 2012 Here we show the feasibility of a novel drug delivery system (DDS), utilizing L-PGDS, for poorly water-soluble compounds such as diazepam (DZP), a major benzodiazepine anxiolytic drug, and 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione (NBQX), an alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and anticonvulsant. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 249-305 prostaglandin D2 synthase (brain) Mus musculus 78-84
20409611-2 2012 Excitotoxic motor neuron death is mediated through the Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type of glutamate receptors and Ca(2+) permeability is determined by the GluR2 subunit. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 131-135 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 210-215
22172932-6 2012 High voltage-gated calcium current (I(HVA)) in hippocampal CA3 neurons was decreased by hypertonicity, whereas the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-induced current in hippocampal CA1 neurons was unaffected. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 115-172 carbonic anhydrase 1 Homo sapiens 211-214
22172932-6 2012 High voltage-gated calcium current (I(HVA)) in hippocampal CA3 neurons was decreased by hypertonicity, whereas the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-induced current in hippocampal CA1 neurons was unaffected. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 174-178 carbonic anhydrase 3 Homo sapiens 59-62
21276434-3 2011 In a postnatal rat cerebellar slice model, we found that TNF-alpha exacerbated AMPA-induced excitotoxicity in Purkinje neurons in a dose-dependent manner beyond the toxicity caused by AMPA alone. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 79-83 tumor necrosis factor Rattus norvegicus 57-66
22225629-1 2012 BACKGROUND: The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 122-180 discs large MAGUK scaffold protein 1 Homo sapiens 16-45
22225629-1 2012 BACKGROUND: The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 122-180 discs large MAGUK scaffold protein 1 Homo sapiens 52-57
22225629-1 2012 BACKGROUND: The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 182-186 discs large MAGUK scaffold protein 1 Homo sapiens 16-45
22225629-1 2012 BACKGROUND: The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 182-186 discs large MAGUK scaffold protein 1 Homo sapiens 52-57
22025073-7 2012 External application of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate (KA) induced vesicular exocytosis and release of sPLA(2)-IIA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 24-80 phospholipase A2 group IIA Homo sapiens 149-160
22025073-7 2012 External application of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate (KA) induced vesicular exocytosis and release of sPLA(2)-IIA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 82-86 phospholipase A2 group IIA Homo sapiens 149-160
21515256-7 2011 The pharmacological profile of NMDA and AMPA-induced arc gene expression in frontal cortical neurons was compared to BDNF. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 40-44 activity-regulated cytoskeleton-associated protein Rattus norvegicus 53-56
21545106-4 2011 Despite possessing similar chemical moieties, crystal structures of glutamate and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) in complex with the ligand-binding core of the GluA2 ionotropic glutamate receptor revealed, contrary to all expectation, two distinct modes of binding. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 82-139 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 194-199
21545106-4 2011 Despite possessing similar chemical moieties, crystal structures of glutamate and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) in complex with the ligand-binding core of the GluA2 ionotropic glutamate receptor revealed, contrary to all expectation, two distinct modes of binding. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 141-145 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 194-199
21276434-3 2011 In a postnatal rat cerebellar slice model, we found that TNF-alpha exacerbated AMPA-induced excitotoxicity in Purkinje neurons in a dose-dependent manner beyond the toxicity caused by AMPA alone. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 184-188 tumor necrosis factor Rattus norvegicus 57-66
21110885-11 2010 Over-expression of ADAR2 reduced AMPA-mediated rise of [Ca2+]i and protected cortical neurons against TD-induced cytotoxicity, whereas down-regulation of ADAR2 increased AMPA-elicited Ca2+ influx and exacerbated TD-induced death of cortical neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 33-37 adenosine deaminase RNA specific B1 Homo sapiens 19-24
20962029-0 2011 The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 26-84 glutamate ionotropic receptor kainate type subunit 1 Rattus norvegicus 4-9
20962029-0 2011 The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 26-84 glutamate ionotropic receptor kainate type subunit 1 Rattus norvegicus 11-16
20971125-3 2011 We have previously found that attenuation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptor activity in one-month-old Cln3(Deltaex1-6) mice resulted in an immediate improvement of their motor skills. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 99-103 ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) Mus musculus 155-159
20971125-4 2011 Here we show that at a later stage of the disease, in 6-7-month-old Cln3(Deltaex1-6) mice, acute inhibition of AMPA receptors by a single intraperitoneal injection (1mg/kg) of the non-competitive AMPA antagonist, EGIS-8332, does not have an immediate effect. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 111-115 ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) Mus musculus 68-72
20456006-2 2010 We previously demonstrated that VEGF also prevents motor neuron death and hindlimb paralysis in rats subjected to alpha-amino-3-hydroxy-5-isoxazolepropionate (AMPA)-induced chronic excitotoxic motor neuron degeneration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 159-163 kinase insert domain receptor Rattus norvegicus 32-36
21110885-11 2010 Over-expression of ADAR2 reduced AMPA-mediated rise of [Ca2+]i and protected cortical neurons against TD-induced cytotoxicity, whereas down-regulation of ADAR2 increased AMPA-elicited Ca2+ influx and exacerbated TD-induced death of cortical neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 170-174 adenosine deaminase RNA specific B1 Homo sapiens 154-159
19151600-3 2009 AMPA (10 microM, 24 h) attenuated the expression of cell surface NR1, an NMDA receptor subunit, and also inhibited glutamate-induced increases in intracellular Ca2+. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 65-68
21364659-8 2010 In addition, we observed that AMPA induced an ER stress response as revealed by alpha subunit of the eukaryotic initiation factor 2alpha phosphorylation, overexpression of GRP chaperones and RyR-dependent cleavage of caspase-12. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 30-34 gastrin releasing peptide Homo sapiens 172-175
21364659-8 2010 In addition, we observed that AMPA induced an ER stress response as revealed by alpha subunit of the eukaryotic initiation factor 2alpha phosphorylation, overexpression of GRP chaperones and RyR-dependent cleavage of caspase-12. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 30-34 ryanodine receptor 2 Homo sapiens 191-194
20534517-4 2010 Here we show that the GSK-3 inhibitor AR-A014418 regulated alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)-induced GluR1 and GluR2 internalization via phosphorylation of kinesin light chain 2 (KLC2), the key molecule of the kinesin cargo delivery system. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 115-119 p21 (RAC1) activated kinase 3 Homo sapiens 38-42
20534517-4 2010 Here we show that the GSK-3 inhibitor AR-A014418 regulated alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)-induced GluR1 and GluR2 internalization via phosphorylation of kinesin light chain 2 (KLC2), the key molecule of the kinesin cargo delivery system. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 115-119 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 129-134
20534517-4 2010 Here we show that the GSK-3 inhibitor AR-A014418 regulated alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)-induced GluR1 and GluR2 internalization via phosphorylation of kinesin light chain 2 (KLC2), the key molecule of the kinesin cargo delivery system. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 115-119 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 139-144
20534517-4 2010 Here we show that the GSK-3 inhibitor AR-A014418 regulated alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)-induced GluR1 and GluR2 internalization via phosphorylation of kinesin light chain 2 (KLC2), the key molecule of the kinesin cargo delivery system. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 115-119 kinesin light chain 2 Homo sapiens 184-205
20534517-4 2010 Here we show that the GSK-3 inhibitor AR-A014418 regulated alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)-induced GluR1 and GluR2 internalization via phosphorylation of kinesin light chain 2 (KLC2), the key molecule of the kinesin cargo delivery system. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 115-119 kinesin light chain 2 Homo sapiens 207-211
20096735-3 2010 Also, the effect of pretreatment with protein kinase inhibitors on scratching behavior by NMDA or AMPA under SP-induced thermal hyperalgesia was examined. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 98-102 tachykinin precursor 1 Homo sapiens 109-111
20096735-5 2010 Furthermore, pretreatment with kinase inhibitors significantly attenuated the enhancement of scratching behavior by NMDA or AMPA under SP-induced thermal hyperalgesia. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 124-128 tachykinin precursor 1 Homo sapiens 135-137
19896473-0 2010 Dysmyelinated axons in shiverer mice are highly vulnerable to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated toxicity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 120-124 myelin basic protein Mus musculus 23-31
20571220-1 2010 alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPARs) are key regulators of synaptic function and cognition. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-57 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 69-75
19946266-3 2009 Here we report the crystal structure of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-sensitive, homotetrameric, rat GluA2 receptor at 3.6 A resolution in complex with a competitive antagonist. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 44-101 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 140-145
19946266-3 2009 Here we report the crystal structure of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-sensitive, homotetrameric, rat GluA2 receptor at 3.6 A resolution in complex with a competitive antagonist. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 103-107 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 140-145
19463813-6 2009 We found that the ionotropic glutamate agonists (NMDA plus AMPA) caused an approximately 6-fold increase of c-fos gene expression in the SON, and some, but not all, G-coupled protein receptor agonists (e.g., phenylephrine, senktide, a NK-3-receptor agonist, and alpha-MSH) increased the c-fos gene expression in the SON from between 1.5 to 2-fold of the control SONs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 59-63 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 108-113
19463813-6 2009 We found that the ionotropic glutamate agonists (NMDA plus AMPA) caused an approximately 6-fold increase of c-fos gene expression in the SON, and some, but not all, G-coupled protein receptor agonists (e.g., phenylephrine, senktide, a NK-3-receptor agonist, and alpha-MSH) increased the c-fos gene expression in the SON from between 1.5 to 2-fold of the control SONs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 59-63 tachykinin receptor 3 Rattus norvegicus 235-248
19463813-6 2009 We found that the ionotropic glutamate agonists (NMDA plus AMPA) caused an approximately 6-fold increase of c-fos gene expression in the SON, and some, but not all, G-coupled protein receptor agonists (e.g., phenylephrine, senktide, a NK-3-receptor agonist, and alpha-MSH) increased the c-fos gene expression in the SON from between 1.5 to 2-fold of the control SONs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 59-63 proopiomelanocortin Rattus norvegicus 262-271
19463813-6 2009 We found that the ionotropic glutamate agonists (NMDA plus AMPA) caused an approximately 6-fold increase of c-fos gene expression in the SON, and some, but not all, G-coupled protein receptor agonists (e.g., phenylephrine, senktide, a NK-3-receptor agonist, and alpha-MSH) increased the c-fos gene expression in the SON from between 1.5 to 2-fold of the control SONs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 59-63 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 287-292
19170166-8 2009 Additionally, other mechanisms of LTP modulation, such as A beta attenuation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor currents, are briefly discussed. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 80-136 amyloid beta (A4) precursor protein Mus musculus 58-64
19003990-4 2009 Overall, the structure of GluR3 (flip) S1S2 is very similar to GluR2 (flop) S1S2 (backbone RMSD of 0.30 +/- 0.05 for glutamate-bound and 0.26 +/- 0.01 for AMPA-bound). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 155-159 glutamate ionotropic receptor AMPA type subunit 3 Homo sapiens 26-31
19225168-1 2009 Brief test-pulse stimulation (0.2-0.05 Hz) of naive (previously nonstimulated) developing hippocampal CA3-CA1 synapses leads to a substantial synaptic depression, explained by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) silencing. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 234-238 carbonic anhydrase 3 Rattus norvegicus 102-109
19054279-6 2009 deltaglt-3-dependent neurodegeneration acts through Ca2+-permeable Glu receptors of the alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) subtype, requires calreticulin function, and is modulated by calcineurin and type-9 adenylyl cyclase (AC9). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 147-151 adenylate cyclase 9 Homo sapiens 255-258
19775504-6 2010 Disruption of AMPA receptor endocytosis with a synthetic peptide containing a short C-terminal sequence of GluR2 (869YKEGYNVYG877, GluR23Y) specifically blocked DCS-induced reversal of AMPA/NMDA ratio and the facilitation of extinction. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 14-18 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 107-112
19595729-0 2009 Transthyretin knockout mice display decreased susceptibility to AMPA-induced neurodegeneration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 64-68 transthyretin Mus musculus 0-13
19595729-4 2009 We show that despite a putative neuroprotective role of TTR, hippocampal slice cultures from TTR KO mice display a decreased susceptibility to AMPA-induced neurodegeneration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 143-147 transthyretin Mus musculus 93-96
19635471-5 2009 The glutamate receptors N-methyl-d-aspartate (NMDA) receptor 1 and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor 2 (GluR2) were substantially lost; specifically, the loss of GluR2 was up to 40% at PSD in AD. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 67-123 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 143-148
19635471-5 2009 The glutamate receptors N-methyl-d-aspartate (NMDA) receptor 1 and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor 2 (GluR2) were substantially lost; specifically, the loss of GluR2 was up to 40% at PSD in AD. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 67-123 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 201-206
19659571-8 2009 In calcium imaging experiments, the blockade of voltage-gated calcium channels by verapamil abolished AMPA-induced calcium responses but only partially reduced NMDA-evoked transients suggesting the expression of calcium-impermeable, GluR2-containing AMPA receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 102-106 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 233-238
19473239-3 2009 In the hippocampal CA1 area, glutamate transmission to the developing, but not to the adult, principal neurons is characterized by the presence of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) silent synapses and of AMPA silencing induced by test pulse stimulation (0.03-1 Hz). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 147-203 carbonic anhydrase 1 Rattus norvegicus 19-22
19473239-3 2009 In the hippocampal CA1 area, glutamate transmission to the developing, but not to the adult, principal neurons is characterized by the presence of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) silent synapses and of AMPA silencing induced by test pulse stimulation (0.03-1 Hz). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 205-209 carbonic anhydrase 1 Rattus norvegicus 19-22
18384650-5 2008 Transient pre-exposure of slice cultures to a combination of LPS and P2X(7) receptor agonists, but not either one or the other alone, significantly exacerbated CA3 pyramidal cell loss induced by subsequent 12 h exposure to 8 microM alpha-amino-3-hydroxy-5-methyl-4-isoxazole propinate (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 286-290 purinergic receptor P2X 7 Homo sapiens 69-84
18713832-7 2008 AMPA plus PMA induced a decrease in surface GluR2 for more than 2 hours. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 44-49
18665322-1 2008 SAP97 gene encodes the synaptic scaffolding PDZ proteins that interact with the L: -alpha-amino-3-hydroxyl-5-methylisoxazole-4-propionate (AMPA), kainate and N-methyl-D: -aspartate (NMDA) type glutamate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 139-143 discs large MAGUK scaffold protein 1 Homo sapiens 0-5
18929546-4 2008 This paper examined the effects of acute PKC inhibition on firing responses to carbachol, NMDA or AMPA using patch clamp recordings from brain slices. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 98-102 proline rich transmembrane protein 2 Homo sapiens 41-44
18403631-8 2008 AMPA-induced differentiation of NPCs to neurons is abrogated by overexpression of ADAR2 in NPCs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 adenosine deaminase RNA specific B1 Homo sapiens 82-87
18317690-5 2008 In vitro, we observed a time and dose-dependent increase in MAPK phosphorylation following exposure to AMPA, which was blocked with AMPA receptor antagonists and the MEK1 inhibitor PD98059. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 103-107 mitogen-activated protein kinase kinase 1 Homo sapiens 166-170
18390640-0 2008 Effect of intravitreal administration of somatostatin and sst2 analogs on AMPA-induced neurotoxicity in rat retina. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 74-78 somatostatin Rattus norvegicus 41-53
17684498-2 2008 The present study evaluated knockout (KO) mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) GluR1 receptor subunit for a range of behaviors considered relevant to certain symptoms of schizophrenia. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 67-113 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 121-126
18412629-2 2008 Exposure of 2-week-old slice cultures, derived from 7-day-old C57BL/6 mice, to 8 microm AMPA, for 24 h, induced degeneration of CA1 and CA3 pyramidal cells, as measured by cellular uptake of propidium iodide (PI). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 88-92 carbonic anhydrase 1 Mus musculus 128-131
18412629-2 2008 Exposure of 2-week-old slice cultures, derived from 7-day-old C57BL/6 mice, to 8 microm AMPA, for 24 h, induced degeneration of CA1 and CA3 pyramidal cells, as measured by cellular uptake of propidium iodide (PI). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 88-92 carbonic anhydrase 3 Mus musculus 136-139
17372971-2 2007 Several lines of evidence have established the inhibitory role of Abeta peptides on hippocampal memory encoding, a process that relies heavily on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 146-202 amyloid beta precursor protein Homo sapiens 66-71
18041091-10 2008 AMPA (10 microM, 24 hr) and SB216763 (10 microM) prominently decreased glutamate-induced caspase-3 cleavage. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 caspase 3 Homo sapiens 89-98
18354017-6 2008 MP reversed AMPA-induced decreases in the expression of anti-apoptotic Bcl-x(L), caspase-3 activation, and DNA laddering, suggesting anti-apoptotic activity in oligodendrocytes. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 12-16 Bcl2-like 1 Rattus norvegicus 71-79
18354017-6 2008 MP reversed AMPA-induced decreases in the expression of anti-apoptotic Bcl-x(L), caspase-3 activation, and DNA laddering, suggesting anti-apoptotic activity in oligodendrocytes. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 12-16 caspase 3 Rattus norvegicus 81-90
17996021-5 2008 Pre-administration of a highly sulfated CS preparation, CS-E, significantly reduced neuronal cell death induced by not only NMDA but also (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid or kainate. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 138-198 choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity) Homo sapiens 56-60
18053990-3 2008 In the presence of Abeta, 2-amino-3-(3-hydoxy-5-methylisoxazol-4-yl) propionic acid (AMPA) glutamate receptor function is disrupted and the surface expression is reduced. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 85-89 amyloid beta precursor protein Homo sapiens 19-24
17963751-9 2008 Here we show that attenuation of AMPA receptor activity by a single intraperitoneal injection of the non-competitive AMPA antagonist, EGIS-8332 (1 mg/kg), significantly improves the motor skills of Cln3(Deltaex1-6) mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 33-37 ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) Mus musculus 198-202
17490438-3 2007 Exposing the cultures to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) plus cyclothiazide (CTZ) led to a transient rise in intracellular (), which was followed by a sustained overload, NKCC1 phosphorylation, and a NKCC1-mediated Na(+) influx. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 25-81 solute carrier family 12 member 2 Rattus norvegicus 203-208
17490438-3 2007 Exposing the cultures to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) plus cyclothiazide (CTZ) led to a transient rise in intracellular (), which was followed by a sustained overload, NKCC1 phosphorylation, and a NKCC1-mediated Na(+) influx. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 25-81 solute carrier family 12 member 2 Rattus norvegicus 232-237
17490438-3 2007 Exposing the cultures to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) plus cyclothiazide (CTZ) led to a transient rise in intracellular (), which was followed by a sustained overload, NKCC1 phosphorylation, and a NKCC1-mediated Na(+) influx. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 83-87 solute carrier family 12 member 2 Rattus norvegicus 203-208
17490438-3 2007 Exposing the cultures to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) plus cyclothiazide (CTZ) led to a transient rise in intracellular (), which was followed by a sustained overload, NKCC1 phosphorylation, and a NKCC1-mediated Na(+) influx. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 83-87 solute carrier family 12 member 2 Rattus norvegicus 232-237
17682049-4 2007 We find that ICAM-5 is cleaved from hippocampal neurons when the cells are treated with N-methyl-d-aspartic acid (NMDA) or alpha-amino-3-hydroxy-5-methylisoxazole-propionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 179-183 intercellular adhesion molecule 5, telencephalin Mus musculus 13-19
17372971-2 2007 Several lines of evidence have established the inhibitory role of Abeta peptides on hippocampal memory encoding, a process that relies heavily on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 204-208 amyloid beta precursor protein Homo sapiens 66-71
17227435-8 2007 The amplitude and frequency of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-mediated miniature excitatory postsynaptic currents (mEPSCs) decreased in hippocampal neurons transfected with active Rap1 or Rap2, associated with reduced surface and total levels of AMPA receptor subunit GluR2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 85-89 RAP1A, member of RAS oncogene family Homo sapiens 209-213
17509083-3 2007 Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA; 1 and 3 microm) concentration-dependently increased firing in 5-HT neurons in both the DRN and the MRN. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-57 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 59-72
17331496-2 2007 (S)-AMPA (0.01-300 microM) induced a concentration-dependent increase in BDNF mRNA and protein expression (EC(50)=7 microM) with maximal increases (50-fold) compared to untreated cultures observed between 5 and 12 h, whereas for cellular protein levels, maximal expression was detected at 24 h. S18986 alone (< or =300 microM) failed to increase basal BDNF expression. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-8 brain-derived neurotrophic factor Rattus norvegicus 73-77
17331496-2 2007 (S)-AMPA (0.01-300 microM) induced a concentration-dependent increase in BDNF mRNA and protein expression (EC(50)=7 microM) with maximal increases (50-fold) compared to untreated cultures observed between 5 and 12 h, whereas for cellular protein levels, maximal expression was detected at 24 h. S18986 alone (< or =300 microM) failed to increase basal BDNF expression. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-8 brain-derived neurotrophic factor Rattus norvegicus 355-359
17331496-3 2007 However, S18986 (300 microM) in the presence of increasing concentrations of (S)-AMPA maximally enhanced AMPA-induced expression of BDNF mRNA and protein levels (3-5-fold). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 77-85 brain-derived neurotrophic factor Rattus norvegicus 132-136
17331496-4 2007 S18986 (100-300 microM) potentiated BDNF mRNA induced by 3 microM (S)-AMPA (2-3-fold). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 66-74 brain-derived neurotrophic factor Rattus norvegicus 36-40
17331496-5 2007 Under similar conditions, the AMPA allosteric modulator cyclothiazide induced a potent stimulation of (S)-AMPA-mediated BDNF expression (40-fold; EC(50)=18 microM), whereas IDRA-21 was inactive. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 102-110 brain-derived neurotrophic factor Rattus norvegicus 120-124
17331496-6 2007 Kinetic studies indicated that S18986 (300 microM) in the presence of 3 microM (S)-AMPA was capable of enhancing BDNF mRNA levels for up to 25 h, compared to 3 microM (S)-AMPA alone. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 79-87 brain-derived neurotrophic factor Rattus norvegicus 113-117
17227435-8 2007 The amplitude and frequency of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-mediated miniature excitatory postsynaptic currents (mEPSCs) decreased in hippocampal neurons transfected with active Rap1 or Rap2, associated with reduced surface and total levels of AMPA receptor subunit GluR2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 85-89 RAP2A, member of RAS oncogene family Homo sapiens 217-221
17227435-8 2007 The amplitude and frequency of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-mediated miniature excitatory postsynaptic currents (mEPSCs) decreased in hippocampal neurons transfected with active Rap1 or Rap2, associated with reduced surface and total levels of AMPA receptor subunit GluR2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 85-89 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 297-302
16791853-8 2006 More important was our finding for the first time that this specific STG antisense ODN diminished AMPA (0.1 mug)-enhanced formalin pain and lost its effect if pretreated with AMPA receptor antagonist CNQX. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 98-102 calcium voltage-gated channel auxiliary subunit gamma 2 Homo sapiens 69-72
17035533-3 2006 CX3CL1-induced EPSC depression is postsynaptic in nature, because paired-pulse ratio was maintained, amplitude distribution of spontaneous excitatory postsynaptic currents shifted to lower values, and whole-cell current responses to AMPA were reversibly inhibited. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 233-237 C-X3-C motif chemokine ligand 1 Rattus norvegicus 0-6
16472927-9 2006 In addition, we have observed AMPA-induced depression of evoked release of GABA and glycine onto lamina I NK1R+ neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 30-34 tachykinin receptor 1 Rattus norvegicus 106-110
16731549-3 2006 Here we compare the kinetic behavior of GluR2 channels activated by four different ligands, glutamate, AMPA, quisqualate, and 2-Me-Tet-AMPA, full agonists that vary in potency by up to two orders of magnitude. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 103-107 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 40-45
16698016-7 2006 However, AMPA induced a dose-dependent increase in the extent of axonal damage visualised by NF200 immunoreactivity but not by APP immunoreactivity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 9-13 neurofilament, heavy polypeptide Mus musculus 93-98
16936133-2 2006 The purpose of this study was to determine the effect of high glucose on the protein content of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and kainate glutamate receptor subunits, particularly the GluR2 subunit, because it controls Ca2+ permeability of AMPA receptor-associated channels. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 154-158 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 218-223
16767516-0 2006 AMPA-induced excitotoxicity increases nuclear levels of CAD, endonuclease G, and acinus and induces chromatin condensation in rat hippocampal pyramidal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 endonuclease G Rattus norvegicus 61-75
16767516-7 2006 Overall, we conclude that: 1) AMPA-induced excitotoxicity increases nuclear immunoreactivity of pro-death enzymes from multiple programmed cell death pathways, 2) differential chromatin condensation patterns occur between CA1 and CA3, and 3) there is no chromatin cleavage within our experimental timeframe. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 30-34 carbonic anhydrase 1 Rattus norvegicus 222-225
16767516-7 2006 Overall, we conclude that: 1) AMPA-induced excitotoxicity increases nuclear immunoreactivity of pro-death enzymes from multiple programmed cell death pathways, 2) differential chromatin condensation patterns occur between CA1 and CA3, and 3) there is no chromatin cleavage within our experimental timeframe. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 30-34 carbonic anhydrase 3 Rattus norvegicus 230-233
16573645-8 2006 These findings suggest that, by selectively reducing AMPA currents and calcium influx, caspase-1 functions as a negative regulator of LTP at hippocampal synapses. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 53-57 caspase 1 Homo sapiens 87-96
16374779-4 2006 Basal cell death of cultured cortical neurons from WT and IL-1ra KO was identical, and treatment with NMDA or AMPA (20 microM) increased cell death to the same extent in WT and IL-1ra KO neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 110-114 interleukin 1 receptor antagonist Mus musculus 177-183
16374779-5 2006 However, basal and NMDA- or AMPA-induced cells death was significantly higher in glial-neuronal co-cultures from IL-1ra KO than from WT mice. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 28-32 interleukin 1 receptor antagonist Mus musculus 113-119
16332687-1 2006 Synapse-associated protein 97 (SAP97) and postsynaptic density 95 (PSD-95) are closely related membrane-associated guanylate kinase homologs (Maguks) implicated in the synaptic targeting and anchoring of alpha-amino-5-methyl-3-hydroxy-4-isoxazolepropionic acid (AMPA)-selective glutamate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 262-266 discs large MAGUK scaffold protein 1 Rattus norvegicus 0-29
16407208-6 2006 Activation of Ras and Erk, but not CREB, occurs through the calcium/calmodulin regulated Ras-GRF1 and Ras-GRF2 exchange factors, which form AMPA-induced complexes with CP-AMPARs but not calcium-impermeable (CI) AMPARs in vivo. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 140-144 mitogen-activated protein kinase 1 Mus musculus 22-25
16407208-6 2006 Activation of Ras and Erk, but not CREB, occurs through the calcium/calmodulin regulated Ras-GRF1 and Ras-GRF2 exchange factors, which form AMPA-induced complexes with CP-AMPARs but not calcium-impermeable (CI) AMPARs in vivo. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 140-144 RAS protein-specific guanine nucleotide-releasing factor 1 Mus musculus 89-97
16332687-1 2006 Synapse-associated protein 97 (SAP97) and postsynaptic density 95 (PSD-95) are closely related membrane-associated guanylate kinase homologs (Maguks) implicated in the synaptic targeting and anchoring of alpha-amino-5-methyl-3-hydroxy-4-isoxazolepropionic acid (AMPA)-selective glutamate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 262-266 discs large MAGUK scaffold protein 1 Rattus norvegicus 31-36
16332687-1 2006 Synapse-associated protein 97 (SAP97) and postsynaptic density 95 (PSD-95) are closely related membrane-associated guanylate kinase homologs (Maguks) implicated in the synaptic targeting and anchoring of alpha-amino-5-methyl-3-hydroxy-4-isoxazolepropionic acid (AMPA)-selective glutamate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 262-266 DLG associated protein 2 Rattus norvegicus 42-65
16332687-1 2006 Synapse-associated protein 97 (SAP97) and postsynaptic density 95 (PSD-95) are closely related membrane-associated guanylate kinase homologs (Maguks) implicated in the synaptic targeting and anchoring of alpha-amino-5-methyl-3-hydroxy-4-isoxazolepropionic acid (AMPA)-selective glutamate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 262-266 DLG associated protein 2 Rattus norvegicus 67-73
16160091-5 2005 NKB also produces a significant enhancement of ionic current through the AMPA receptors activated directly by its agonist AMPA and cyclothiazide, an allosteric modulator that selectively suppresses desensitization of AMPA receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 73-77 tachykinin precursor 3 Rattus norvegicus 0-3
17725505-13 2006 As in MF, pairing GDPs with Schaffer collateral stimulation induced a persistent potentiation of spontaneous and evoked alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-mediated responses at poorly developed CA3-CA1 synapses. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 179-183 carbonic anhydrase 3 Homo sapiens 224-231
16135094-2 2005 Two months after septal microinjection of 2.7 nmol alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA), a 220% increase of GABA(A) receptor labelling in the hippocampal CA3 and the hilus was shown, and also changes in hippocampal neurotransmission characterised by in vivo microdialysis and HPLC. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 105-109 carbonic anhydrase 3 Rattus norvegicus 177-180
15893467-2 2005 Under these conditions, AMPA toxicity was reverted, an effect that was likely related to increased production and release of GDNF, as shown by RT-PCR, Western blot analysis and ELISA assay. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 24-28 glial cell derived neurotrophic factor Homo sapiens 125-129
15893467-3 2005 In addition, treatment with GDNF during the 24 h that followed the AMPA pulse produced a similar neuroprotective effect, whereas addition of a neutralizing anti-GDNF antibody prevented neuroprotection. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 67-71 glial cell derived neurotrophic factor Homo sapiens 28-32
16358339-3 2006 We have reported previously that IL-1 markedly enhances excitotoxic injury induced in the rat by striatal administration of the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), leading to widespread neuronal loss throughout the ipsilateral cortex. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 194-198 interleukin 1 alpha Homo sapiens 33-37
15736951-3 2005 NMR spin relaxation measurements for backbone amide (15)N nuclei reveal that GluR2 S1S2 exhibits reduced chemical exchange line broadening, resulting from microsecond-to-millisecond conformational dynamics, in AMPA-bound compared to glutamate- and quisqualate-bound states. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 210-214 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 77-82
15869941-0 2005 Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 138-142 tumor necrosis factor Homo sapiens 0-27
15869941-0 2005 Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 138-142 tumor necrosis factor Homo sapiens 29-38
15869941-0 2005 Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 138-142 teashirt zinc finger homeobox 1 Homo sapiens 153-159
16033883-6 2005 Decreasing the concentration of TNF-alpha to 1 ng/ml resulted in neuroprotection against AMPA-induced neuronal death independently on the application protocol. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 89-93 tumor necrosis factor Mus musculus 32-41
16033883-7 2005 By using TNF-alpha receptor (TNFR) knock-out mice, we demonstrated that the potentiation of AMPA-induced toxicity by TNF-alpha involves TNF receptor-1, whereas the neuroprotective effect is mediated by TNF receptor-2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 92-96 tumor necrosis factor receptor superfamily, member 1a Mus musculus 9-27
16033883-7 2005 By using TNF-alpha receptor (TNFR) knock-out mice, we demonstrated that the potentiation of AMPA-induced toxicity by TNF-alpha involves TNF receptor-1, whereas the neuroprotective effect is mediated by TNF receptor-2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 92-96 tumor necrosis factor receptor superfamily, member 1a Mus musculus 29-33
16033883-7 2005 By using TNF-alpha receptor (TNFR) knock-out mice, we demonstrated that the potentiation of AMPA-induced toxicity by TNF-alpha involves TNF receptor-1, whereas the neuroprotective effect is mediated by TNF receptor-2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 92-96 tumor necrosis factor Mus musculus 9-18
15706230-2 2005 In-vivo experiments were conducted in Sprague-Dawley rats to evaluate the effects of CARTp on thermal hyperalgesia induced by NMDA or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 134-190 CART prepropeptide Rattus norvegicus 85-90
15784965-3 2005 This Amph-induced decrease seems to involve L-type voltage-gated Ca2+ channels, because the AMPA-induced 45Ca2+ uptake was blocked by 70% and 80%, respectively, for untreated and Amph-treated neurons in the presence of nifedipine (1 microM), an antagonist to L-type calcium channels. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 92-96 carbonic anhydrase 2 Rattus norvegicus 65-68
15690046-4 2005 Here, we present the structure of native AMPA receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; AMPA-Rs) purified from rat brain, as determined by single-particle electron microscopy. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 57-114 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 116-123
15736951-1 2005 Chemical shift changes and internal motions on microsecond-to-millisecond time scales of the S1S2 ligand-binding domain of the GluR2 ionotropic glutamate receptor have been studied by NMR spectroscopy in the presence of the agonists glutamic acid (glutamate), quisqualic acid (quisqualate), and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 295-352 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 127-132
15736951-1 2005 Chemical shift changes and internal motions on microsecond-to-millisecond time scales of the S1S2 ligand-binding domain of the GluR2 ionotropic glutamate receptor have been studied by NMR spectroscopy in the presence of the agonists glutamic acid (glutamate), quisqualic acid (quisqualate), and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 354-358 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 127-132
15784965-7 2005 The data suggest that acute action of Amph on brain neurons is possibly associated with decreased AMPA-mediated Ca2+ influx and current amplitude, as well as modified expression of the GluR2 mRNA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 98-102 carbonic anhydrase 2 Rattus norvegicus 112-115
15651916-8 2004 When subfield analysis was performed on the cultures, the CA1 subfield was most susceptible to glutamate, NMDA and AMPA, while CA3 was most susceptible to kainic acid. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 115-119 carbonic anhydrase 1 Homo sapiens 58-61
15522236-4 2004 Our results demonstrated that both c-fos mRNA and protein were dramatically induced following treatment with various glutamate receptor agonists (500muM); N-methyl-d-aspartic acid, kainic acid, (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, and (RS)-3,5-dihydroxyphenylglycine. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 194-254 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 35-40
15531093-0 2004 (S)-AMPA inhibits electrically evoked calcitonin gene-related peptide (CGRP) release from the rat dorsal horn: reversal by cannabinoid receptor antagonist SR141716A. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-8 calcitonin-related polypeptide alpha Rattus norvegicus 38-69
15531093-0 2004 (S)-AMPA inhibits electrically evoked calcitonin gene-related peptide (CGRP) release from the rat dorsal horn: reversal by cannabinoid receptor antagonist SR141716A. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-8 calcitonin-related polypeptide alpha Rattus norvegicus 71-75
15531093-4 2004 Superfusion of either WIN55,212-2 (1 microM) or (S)-AMPA (1 microM) significantly attenuated CGRP release in a CB(1)-dependent manner (SR141716A, 5 microM). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 48-56 calcitonin-related polypeptide alpha Rattus norvegicus 93-97
15260958-3 2004 The intracellular accumulation of GluR2 and GluR3 but not GluR1 is enhanced by AMPA, NMDA, or synaptic activity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 79-83 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 34-39
15344919-6 2004 The reduced AMPA receptor levels caused by the lack of the GluR-A subunit, and measured by a 30% reduction in hippocampal [3H]-S-AMPA binding, seem to be the reason for suppressed male aggressiveness. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 12-16 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 59-65
15260958-3 2004 The intracellular accumulation of GluR2 and GluR3 but not GluR1 is enhanced by AMPA, NMDA, or synaptic activity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 79-83 glutamate ionotropic receptor AMPA type subunit 3 Homo sapiens 44-49
15100219-1 2004 In the present report, using vibrational spectroscopy we have probed the ligand-protein interactions for full agonists (glutamate and alpha-amino-5-methyl-3-hydroxy-4-isoxazole propionate (AMPA)) and a partial agonist (kainate) in the isolated ligand-binding domain of the GluR2 subunit of the glutamate receptor. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 189-193 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 273-278
15016079-10 2004 The NMDA- and AMPA/kainate-induced CREB phosphorylation was completely and partially blocked by U0126, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 14-18 cAMP responsive element binding protein 1 Rattus norvegicus 35-39
15033339-6 2004 AMPA, ATPA and (S)-5-iodowillardiine did activate GluR6/KA2 heteromers, but only as partial agonists. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 glutamate ionotropic receptor kainate type subunit 2 Homo sapiens 50-55
15033339-6 2004 AMPA, ATPA and (S)-5-iodowillardiine did activate GluR6/KA2 heteromers, but only as partial agonists. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 glutamate ionotropic receptor kainate type subunit 5 Homo sapiens 56-59
14529709-7 2003 AMPA or NMDA treatment decreased phospho-Thr(34)-DARPP-32 levels, effects that were blocked by receptor antagonists, or cyclosporin A. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus 49-57
15350654-4 2004 Therefore, the impact of synaptic currents on firing in GnRH neurons was directly examined using simulated (S)-alpha-amino-3-hydroxy-5-methyl-isoxazolepropionic acid (AMPA)-like inputs applied with the method of dynamic current clamping. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 167-171 gonadotropin releasing hormone 1 Homo sapiens 56-60
14642640-0 2003 AMPA-induced dark cell degeneration of cerebellar Purkinje neurons involves activation of caspases and apparent mitochondrial dysfunction. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 caspase 9 Homo sapiens 90-98
15031678-0 2004 AMPA, not NMDA, activates RhoA GTPases and subsequently phosphorylates moesin. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 ras homolog family member A Rattus norvegicus 26-30
15031678-0 2004 AMPA, not NMDA, activates RhoA GTPases and subsequently phosphorylates moesin. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 moesin Rattus norvegicus 71-77
14656333-9 2003 Upon various glutamate agonist infusions, only alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) increased sgk mRNA levels significantly in the hippocampus. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 105-109 serum/glucocorticoid regulated kinase 1 Rattus norvegicus 121-124
14572457-4 2003 Accordingly, we monitored AMPA-triggered currents through GABAergic neurons: Chronic BDNF treatment increased the AMPA-triggered currents but not NMDA-triggered currents in culture. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 26-30 brain derived neurotrophic factor Mus musculus 85-89
12764115-8 2003 In vasopressin neurons, both vasopressin and a V1a receptor agonist, F-180, decreased AMPA-induced currents, an effect blocked by a V1a receptor antagonist SR49059. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 86-90 arginine vasopressin Homo sapiens 3-14
12878687-6 2003 Comparison of neuronal cultures from wild-type mice and mice lacking IL-1ra (knock-out) indicates that endogenous IL-1ra is essential for the neuro-protective effects of CBs against excessive activation of glutamate receptors (excitotoxicity) in response to S-AMPA or NMDA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 258-264 interleukin 1 receptor antagonist Mus musculus 114-120
12764115-8 2003 In vasopressin neurons, both vasopressin and a V1a receptor agonist, F-180, decreased AMPA-induced currents, an effect blocked by a V1a receptor antagonist SR49059. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 86-90 arginine vasopressin Homo sapiens 29-40
12694947-2 2003 AMPA (10 or 100 microM) current was inhibited by GYKI 52466, a selective AMPA receptor (AMPAR) antagonist, in all neurons isolated on postnatal day (PD) 5-8, PD 12-15 or PD 32-35. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 88-93
12682273-3 2003 We discovered that normal human T cells, human T leukemia cells, and mouse anti-myelin basic protein T cells express high levels of glutamate ion channel receptor (ionotropic) of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype 3 (GluR3). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 179-235 glutamate ionotropic receptor AMPA type subunit 3 Homo sapiens 254-259
12532411-1 2003 By using immunohistochemical methods, we examined the distribution of cells expressing subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-selective glutamate receptors (GluR2/3) in the cortical areas of the occipitotemporal pathway in monkeys. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 153-157 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 190-195
12735631-7 2003 At the same time DHPG enhanced ionophoretic responses to alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), kainic acid (KA), and N-methyl-D-aspartate (NMDA) in CA1 pyramidal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 57-114 carbonic anhydrase 1 Rattus norvegicus 176-179
12354762-3 2002 The A-kinase anchoring protein, AKAP79, is a multivalent anchoring protein that maintains the cAMP-dependent protein kinase, protein kinase C, and protein phosphatase-2B (PP2B/calcineurin) at the postsynaptic membrane of excitatory synapses where it is recruited into complexes with N-methyl-d-aspartic acid or alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA)-subtype glutamate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 370-374 A-kinase anchoring protein 5 Homo sapiens 32-38
12598595-6 2003 Intracellular perfusion of the catalytic subunit of PKA potentiated endogenous synaptic and (exogenously applied) AMPA-induced currents in XII motoneurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 114-118 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 52-55
12011465-5 2002 The lack of NSF binding, however, resulted in receptors that were endocytosed to a greater extent than wild-type receptors in response to application of AMPA or N-methyl-d-aspartate (NMDA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 153-157 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 12-15
12507323-2 2002 Among subunits of the AMPA receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid), subunit 2 (GluR2) is of special significance because it controls their Ca2+ permeability. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 38-95 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 109-114
11835309-1 2002 Interleukin (IL)-1beta mediates diverse forms of neurodegeneration and exacerbates cell death induced by striatal injection of the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) in the rat brain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 143-200 interleukin 1 beta Rattus norvegicus 0-22
11835309-1 2002 Interleukin (IL)-1beta mediates diverse forms of neurodegeneration and exacerbates cell death induced by striatal injection of the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) in the rat brain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 202-206 interleukin 1 beta Rattus norvegicus 0-22
11279267-8 2001 Additionally, cerebellar but not cortical PSDs exhibited significantly lower enrichment of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) GluR1. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 91-147 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 155-160
11589995-3 2001 Our recent data suggest that the pro-inflammatory cytokine interleukin-1beta (IL-1beta) acts at specific sites (e.g., the striatum) in the rat brain to cause distant cortical injury, when co-administered with the potent excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 286-292 interleukin 1 beta Rattus norvegicus 59-76
11589995-3 2001 Our recent data suggest that the pro-inflammatory cytokine interleukin-1beta (IL-1beta) acts at specific sites (e.g., the striatum) in the rat brain to cause distant cortical injury, when co-administered with the potent excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 286-292 interleukin 1 beta Rattus norvegicus 78-86
11526992-5 2001 Chronic, not acute, exposure to olanzapine was capable of up-regulating hippocampal mRNA levels for GluR-B and GluR-C, two alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)-forming subunits. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 123-181 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 100-106
11526992-5 2001 Chronic, not acute, exposure to olanzapine was capable of up-regulating hippocampal mRNA levels for GluR-B and GluR-C, two alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)-forming subunits. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 123-181 glutamate ionotropic receptor AMPA type subunit 3 Rattus norvegicus 111-117
12453476-14 2002 Application of NMDA or AMPA induced internalization of NK1 receptor. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 23-27 tachykinin receptor 1 Rattus norvegicus 55-67
11279267-8 2001 Additionally, cerebellar but not cortical PSDs exhibited significantly lower enrichment of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) GluR1. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 149-153 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 155-160
11043903-1 2000 Striatal coadministration of interleukin-1beta (IL-1beta) with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA) in rats results in widespread cortical cell death not caused by either treatment alone. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 117-123 interleukin 1 beta Rattus norvegicus 29-46
11279263-3 2001 Kainic acid and AMPA, but not NMDA, caused remarkable increases in BDNF protein in the rat hippocampus and entorhinal cortex. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 16-20 brain-derived neurotrophic factor Rattus norvegicus 67-71
11209937-3 2001 C3a prevented neither serum deprivation-induced apoptotic neuronal death, nor AMPA/kainate-mediated excitotoxicity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 78-82 complement C3 Homo sapiens 0-3
11293504-8 2001 These results are generally consistent with the sensitization characteristics in diverse pain models and suggests that the modulatory effects of SP and CGRP on NMDA and non-NMDA (AMPA) response are, at least in part, contribute to the development of sensitization in various pain models. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 179-183 calcitonin-related polypeptide alpha Rattus norvegicus 152-156
11770127-2 2001 After stereotaxic microinjection of N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methyl isoxazole-4-propionic acid (AMPA) to CA1 of rat hippocampus, the animals were sacrificed: 0 h, 2 h, 12 h, 24 h and 3 days after the insult. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 126-130 carbonic anhydrase 1 Rattus norvegicus 135-138
11119696-11 2000 In slices from post-ischemia animals, CA1 neurons with robust action potentials exhibit greatly enhanced AMPA-elicited rises in intracellular Ca(2+). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 105-109 carbonic anhydrase 1 Rattus norvegicus 38-41
10931951-4 2000 Here we show that, in both CA3 and CA1 hippocampal regions, AMPA-mediated synaptic responses can be detected already at early stages of postnatal development. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 60-64 carbonic anhydrase 3 Homo sapiens 27-30
10991955-5 2000 Under hydrolyzing conditions, when NAALADase was active, NAAG had toxic effects that were blocked by NMDA and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor antagonists and by NAALADase inhibition. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 168-172 folate hydrolase 1B (pseudogene) Homo sapiens 35-44
10991955-5 2000 Under hydrolyzing conditions, when NAALADase was active, NAAG had toxic effects that were blocked by NMDA and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor antagonists and by NAALADase inhibition. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 168-172 folate hydrolase 1B (pseudogene) Homo sapiens 210-219
10931951-4 2000 Here we show that, in both CA3 and CA1 hippocampal regions, AMPA-mediated synaptic responses can be detected already at early stages of postnatal development. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 60-64 carbonic anhydrase 1 Homo sapiens 35-38
10915578-8 2000 NBQX suppressed the expression of c-fos mRNA in the IC induced by AMPA-induced seizures but did not suppress c-fos mRNA in PTU rats or rats with cyclothiazide-induced seizures. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 66-70 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 34-39
10517271-1 1999 Human embryonic kidney cells (HEK293), expressing the human GluR4 receptor sub-unit of 2-amino-3-hydroxy-methylisoxazol-4-ylpropionic acid (AMPA) type non-NMDA receptors were used, in combination with Cytostar-T scintillating microplates, to develop an assay system for the screening of novel compounds with potential AMPA antagonistic characteristics. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 140-144 glutamate ionotropic receptor AMPA type subunit 4 Homo sapiens 60-65
10963901-3 2000 Epo (30 pM) reduced neuronal, but not astroglial, cell death from hypoxia with glucose deprivation, and also attenuated the neurotoxic effect of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), but not other excitotoxins. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 209-213 erythropoietin Rattus norvegicus 0-3
10634879-2 2000 It has been reported that in the CA3-CA1 pyramidal cells a conversion of "silent" glutamatergic synapses to conductive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) synapses starts gradually after P2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 119-175 carbonic anhydrase 3 Rattus norvegicus 33-36
10634879-2 2000 It has been reported that in the CA3-CA1 pyramidal cells a conversion of "silent" glutamatergic synapses to conductive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) synapses starts gradually after P2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 119-175 carbonic anhydrase 1 Rattus norvegicus 37-40
10634879-2 2000 It has been reported that in the CA3-CA1 pyramidal cells a conversion of "silent" glutamatergic synapses to conductive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) synapses starts gradually after P2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 177-181 carbonic anhydrase 3 Rattus norvegicus 33-36
10634879-2 2000 It has been reported that in the CA3-CA1 pyramidal cells a conversion of "silent" glutamatergic synapses to conductive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) synapses starts gradually after P2. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 177-181 carbonic anhydrase 1 Rattus norvegicus 37-40
10608276-2 1999 ATPA is a tert-butyl analogue of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid) that has been shown to possess high affinity for the GluR5 subunit of kainate receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 39-96 glutamate ionotropic receptor kainate type subunit 1 Homo sapiens 151-156
10737619-6 2000 AMPA (3 microM) increased the number of apoptotic nuclei to 60% of control in wild-type cultures, and human Bcl-2 significantly decreased the number of apoptotic nuclei to 30% of AMPA-treated cultures. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 179-183 BCL2 apoptosis regulator Homo sapiens 108-113
10467233-10 1999 administration of AMPA and increased 120 min after NBQX treatment, whereas serum GH levels increased after AMPA treatment and decreased after NBQX administration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 107-111 gonadotropin releasing hormone receptor Rattus norvegicus 81-83
10334499-4 1999 Moreover, 3-nitropropionic acid given in a subthreshold dose potently enhanced seizures generated by intracerebroventricular administration of AMPA and kainate, lowering their CD50 from 0.98 (0.83-1.17) and 0.73 (0.64-0.83) to 0.55 (0.45-0.66) (P<0.001) and 0.58 (0.51-0.65) (P<0.05) nmol, respectively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 143-147 intercellular adhesion molecule 5, telencephalin Mus musculus 176-180
10366745-2 1999 Changes in trk mRNAs induced by quinolinate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), kainate or 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) were analyzed by a ribonuclease protection assay. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 99-103 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 11-14
10319342-6 1999 The increase in Fos-LI positive neurons in dorsal horn was reversed by a further supplement of MK801, an N-methyl-D-aspartate (NMDA) receptor antagonist, but not of CNQX, an alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/kainate antagonist. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 233-237 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 16-19
10199666-6 1999 In aqueous solution and in 50% (v/v) trifluoroethanol, the most effective bridge for helix stabilization consisted of a 4-(aminomethyl)phenylacetic acid residue (AMPA) linked by amide bonds to the side chain functional groups of a (S)-2,3-diaminopropionic acid residue (Dap) in position 3 of the model peptide and an aspartic acid residue in position 10. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 162-166 death associated protein Homo sapiens 270-273
10027859-6 1999 In these cells, the expression of heteromeric GluR6-R subunit-containing receptors was confirmed by testing their sensitivity to 1 mM alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 134-191 glutamate ionotropic receptor kainate type subunit 2 Homo sapiens 46-51
10085365-5 1999 The slopes of the input/output curves of both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) postsynaptic currents were steeper in EST-treated CA1 neurons, consistent with the observed increase in synapse density. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 46-102 carbonic anhydrase 1 Homo sapiens 192-195
10561704-6 1999 (S)-ATPO did not show detectable agonist effects at any of the receptors under study, but antagonized AMPA-induced depolarization in the cortical wedge preparation (IC(50) = 15 +/- 1 microM). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 102-106 ATP synthase peripheral stalk subunit OSCP Rattus norvegicus 4-8
9707429-1 1998 In order to identify key structural determinants for ligand recognition, we subjected the ligand-binding domain of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective glutamate receptor GluR-D subunit to site-directed mutagenesis. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 178-182 glutamate ionotropic receptor AMPA type subunit 4 Homo sapiens 213-219
9875720-0 1998 COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 88-92 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5
10069578-3 1998 NGF up-regulation was also apparent in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) treatment from 6 to 16 h postinjection. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 93-97 nerve growth factor Rattus norvegicus 0-3
10069578-4 1998 Instead, BDNF was up-regulated only at 6 h after kainate or AMPA excitotoxicity. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 60-64 brain-derived neurotrophic factor Rattus norvegicus 9-13
9778185-2 1998 Bath application of N-methyl-D-aspartic acid (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and kainate showed that NMDA-, AMPA- and kainate-induced currents were enhanced in postischemic CA1 pyramidal neurons at 1 to 12 hours after 5-minute ischemia. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 145-149 carbonic anhydrase 1 Homo sapiens 210-213
9818728-7 1998 Alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate (AMPA) binding correlated with group proximity scores in frontal and parietal cortices and within the CA1 and CA3 regions of the hippocampus. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 55-59 carbonic anhydrase 1 Mus musculus 156-159
9818728-7 1998 Alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate (AMPA) binding correlated with group proximity scores in frontal and parietal cortices and within the CA1 and CA3 regions of the hippocampus. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 55-59 carbonic anhydrase 3 Mus musculus 164-167
9724806-9 1998 In addition, simultaneous delivery of NGF prevented significant increases in NOS activity triggered by the glutamate receptor agonists N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 167-223 nerve growth factor Rattus norvegicus 38-41
9724806-9 1998 In addition, simultaneous delivery of NGF prevented significant increases in NOS activity triggered by the glutamate receptor agonists N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 225-229 nerve growth factor Rattus norvegicus 38-41
9655812-4 1998 Treatment of the slices with the glutamate receptor agonists kainate or alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid significantly decreased the percentage of LB1(+), NG2(+) and O4(+) cells, and their bromodeoxyuridine labeling index. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 72-129 cytoskeleton associated protein 2 Homo sapiens 172-175
9618548-2 1998 Global ischemia in rats and gerbils induces down-regulation of GluR2 mRNA and increased alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced Ca2+ influx in CA1 before neurodegeneration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 146-150 carbonic anhydrase 2 Rattus norvegicus 160-163
9619504-3 1998 The distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) class of glutamate receptors (GluRs) with different calcium permeabilities has been proposed as an explanation for this differential vulnerability. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 24-80 glutamyl-tRNA synthetase 2, mitochondrial Mus musculus 97-116
9619504-3 1998 The distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) class of glutamate receptors (GluRs) with different calcium permeabilities has been proposed as an explanation for this differential vulnerability. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 24-80 glutamyl-tRNA synthetase 2, mitochondrial Mus musculus 118-123
9619504-3 1998 The distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) class of glutamate receptors (GluRs) with different calcium permeabilities has been proposed as an explanation for this differential vulnerability. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 82-86 glutamyl-tRNA synthetase 2, mitochondrial Mus musculus 97-116
9619504-3 1998 The distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) class of glutamate receptors (GluRs) with different calcium permeabilities has been proposed as an explanation for this differential vulnerability. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 82-86 glutamyl-tRNA synthetase 2, mitochondrial Mus musculus 118-123
9618548-2 1998 Global ischemia in rats and gerbils induces down-regulation of GluR2 mRNA and increased alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced Ca2+ influx in CA1 before neurodegeneration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 146-150 carbonic anhydrase 1 Rattus norvegicus 175-178
9572271-0 1998 The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 101-106 tumor necrosis factor Rattus norvegicus 142-169
9572271-4 1998 Long-term treatment with TNF alpha caused a decrease in currents induced by glutamate, NMDA, AMPA, and kainate. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 93-97 tumor necrosis factor Rattus norvegicus 25-34
9134962-1 1997 Effects of the glutamate receptor agonists, N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), on the activator protein-1 (AP-1) DNA binding activity were studied in primary cultures of rat cerebellar granule cells. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 76-132 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 148-167
9825961-2 1998 Downregulation of glutamate receptor 2 (GluR2) subunit mRNA [the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) subunit that limits Ca2+ permeability] is thought to a play role in this neurodegeneration, possibly by increased formation of Ca2+ permeable AMPA receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 124-128 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 18-38
9825961-2 1998 Downregulation of glutamate receptor 2 (GluR2) subunit mRNA [the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) subunit that limits Ca2+ permeability] is thought to a play role in this neurodegeneration, possibly by increased formation of Ca2+ permeable AMPA receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 124-128 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 40-45
9825961-2 1998 Downregulation of glutamate receptor 2 (GluR2) subunit mRNA [the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) subunit that limits Ca2+ permeability] is thought to a play role in this neurodegeneration, possibly by increased formation of Ca2+ permeable AMPA receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 124-128 carbonic anhydrase 2 Homo sapiens 150-153
9825961-2 1998 Downregulation of glutamate receptor 2 (GluR2) subunit mRNA [the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) subunit that limits Ca2+ permeability] is thought to a play role in this neurodegeneration, possibly by increased formation of Ca2+ permeable AMPA receptors. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 124-128 carbonic anhydrase 2 Homo sapiens 257-260
9300398-1 1997 L-Glutamate, N-methyl-D-aspartate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and kainate increased the release of neuropeptide Y-like immunoreactivity from primary cultures of rat hippocampal neurons incubated in Mg2+(1.2 mM)-containing medium. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 93-97 neuropeptide Y Rattus norvegicus 136-150
9300398-8 1997 Cyclothiazide (10 microM), a drug known to prevent AMPA receptor desensitization, enhanced the neuropeptide Y-like immunoreactivity release elicited by 100 microM AMPA, but not that caused by 100 microM kainate. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 51-55 neuropeptide Y Rattus norvegicus 95-109
9382469-0 1997 A Bcl-2 antisense oligonucleotide increases alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) toxicity in cortical cultures. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 102-106 BCL2, apoptosis regulator Rattus norvegicus 2-7
9382469-4 1997 This effect was accompanied by the induction of Bcl-2 protein expression, with maximal induction at 100 microM AMPA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 111-115 BCL2, apoptosis regulator Rattus norvegicus 48-53
9382469-5 1997 A phosphorothioate antisense ODN against Bcl-2 reduced the AMPA-stimulated induction of Bcl-2 protein levels, detected by western blotting, by about 70%. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 59-63 BCL2, apoptosis regulator Rattus norvegicus 41-46
9382469-5 1997 A phosphorothioate antisense ODN against Bcl-2 reduced the AMPA-stimulated induction of Bcl-2 protein levels, detected by western blotting, by about 70%. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 59-63 BCL2, apoptosis regulator Rattus norvegicus 88-93
9299552-4 1997 On the other hand, fetal bovine serum enhanced kainate-evoked currents in oocytes expressing the alpha-amino3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, GluR1,3. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 97-152 glutamate receptor, ionotropic, AMPA 1 L homeolog Xenopus laevis 171-176
9388556-0 1997 Ligand recognition in glutamate receptors: insights from mutagenesis of the soluble alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-binding domain of glutamate receptor type D (GluR-D). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 143-147 glutamate ionotropic receptor AMPA type subunit 4 Homo sapiens 167-192
9388556-0 1997 Ligand recognition in glutamate receptors: insights from mutagenesis of the soluble alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-binding domain of glutamate receptor type D (GluR-D). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 143-147 glutamate ionotropic receptor AMPA type subunit 4 Homo sapiens 194-200
9662141-8 1998 Non-neurodegenerative doses of (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA, 0.3 nmol) caused modest increases in NPY mRNA levels in ipsilateral interneurons, whereas neurodegenerative doses (1-10 nmol) induced markedly increased NPY mRNA levels in granule cells (up to 11-fold) and interneurons (up to threefold). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 90-94 neuropeptide Y Rattus norvegicus 133-136
9662141-8 1998 Non-neurodegenerative doses of (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA, 0.3 nmol) caused modest increases in NPY mRNA levels in ipsilateral interneurons, whereas neurodegenerative doses (1-10 nmol) induced markedly increased NPY mRNA levels in granule cells (up to 11-fold) and interneurons (up to threefold). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 90-94 neuropeptide Y Rattus norvegicus 249-252
9134962-1 1997 Effects of the glutamate receptor agonists, N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), on the activator protein-1 (AP-1) DNA binding activity were studied in primary cultures of rat cerebellar granule cells. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 76-132 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 169-173
8921289-1 1996 The functional interaction of thiocyanate (SCN-) ions with recombinant non-N-methyl-D-aspartate receptors was examined by studying alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)- and kainic acid (KA)-activated currents in Xenopus laevis oocytes. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 131-187 sorcin S homeolog Xenopus laevis 43-46
9175612-5 1997 L-AP4 (IC50 = >300 microM), D-AP4 (IC50 = >100 microM) and L-SOP (IC50 = 199 +/- 6 microM) inhibited 6 microM (S)-AMPA-stimulated 57Co2+ influx, whereas L-CCG-1 (up to 10 microM), 300 microM (RS)-3,5-dihydroxyphenylglycine, 300 microM (+/-)-baclofen and 1 mM carbachol were ineffective. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 116-124 DLG associated protein 4 Homo sapiens 31-36
9027383-3 1997 The highly selective NK1 receptor agonist acetyl-[Arg6,Sar9,Met(O2)11]-SP6-11 (Sar9-SP) greatly facilitated this response, but under the present conditions had no effect when applied alone or with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor agonist) at the same current. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 197-253 tachykinin receptor 1 Rattus norvegicus 21-33
9445090-1 1997 In adult rats, kainic acid-induced status epilepticus markedly reduces GluR2 (the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid, AMPA subunit that limits Ca2+ permeability), receptor mRNA in the vulnerable CA3 and may contribute to delayed neurodegeneration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 82-139 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 71-76
9445090-1 1997 In adult rats, kainic acid-induced status epilepticus markedly reduces GluR2 (the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid, AMPA subunit that limits Ca2+ permeability), receptor mRNA in the vulnerable CA3 and may contribute to delayed neurodegeneration. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 82-139 carbonic anhydrase 2 Rattus norvegicus 166-169
9041561-4 1997 Two hundred micromolar 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a competitive non-NMDA glutamate receptor antagonist, reversed the effects of a 100 microM AMPA on dialysate 5-HT and 5-HIAA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 159-163 glutamate ionotropic receptor NMDA type subunit 2C Rattus norvegicus 86-109
8987153-1 1997 Direct postsynaptic depolarization and firing of single CA1 neurons caused decreased responses to iontophoresed alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 112-169 carbonic anhydrase 1 Homo sapiens 56-59
8987153-1 1997 Direct postsynaptic depolarization and firing of single CA1 neurons caused decreased responses to iontophoresed alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 171-175 carbonic anhydrase 1 Homo sapiens 56-59
8921289-1 1996 The functional interaction of thiocyanate (SCN-) ions with recombinant non-N-methyl-D-aspartate receptors was examined by studying alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)- and kainic acid (KA)-activated currents in Xenopus laevis oocytes. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 189-193 sorcin S homeolog Xenopus laevis 43-46
8836240-16 1996 Unlike homomeric GluR6(R) channels, GluR6(R)/KA2 heteromers were activated by alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) (0.25-5 mM). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 137-141 glutamate ionotropic receptor kainate type subunit 2 Homo sapiens 36-41
8873121-6 1996 These small decreases in [Ca2+]o were reversibly reduced by kainate, RS-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), N-methyl-D-aspartate (NMDA) and L-glutamic acid (glutamate), without effects on afferent volleys. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 130-134 carbonic anhydrase 2 Rattus norvegicus 26-29
8874155-3 1996 The inhibitory actions of ethanol on alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-stimulated AP-1 binding were considerably weaker as compared to the effects seen following administration of NMDA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 37-94 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 113-117
8836240-16 1996 Unlike homomeric GluR6(R) channels, GluR6(R)/KA2 heteromers were activated by alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) (0.25-5 mM). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 137-141 glutamate ionotropic receptor kainate type subunit 5 Homo sapiens 45-48
8815209-9 1996 AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate) or kainate applications produced small but significant Ca2+ entry. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 carbonic anhydrase 2 Rattus norvegicus 115-118
8717068-10 1996 Similar [Ca2+]i increases in the CA1 field were induced by a Ca(2+)-free in vitro ischaemia, a high concentration of KCl or by specific agonists for glutamate receptor subtypes (N-methyl-D-aspartate (NMDA), (s)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and kainate); these increases were also depressed with 43 mumol/L ibudilast present in the perfusion medium. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 265-269 carbonic anhydrase 1 Homo sapiens 33-36
8522955-5 1996 The 5-HT1A receptor antagonist (S)-(+)N-tert-butyl-3-[4-(2- methoxyphenyl)piperazin-1-yl]-2-phenylpropionamide dihydrochloride [(+)-WAY 100135] did not prevent the inhibition of glutamate release by 5-HT but blocked the inhibition by 8-OH-DPAT of the NMDA/AMPA-evoked cGMP responses. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 256-260 5-hydroxytryptamine receptor 1A Rattus norvegicus 4-10
8713451-4 1996 Brief exposures (5 min) of both NR1+/+ and NR1+/- neuronal cells to glutamate or NMDA, but not kainate or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), resulted in widespread neuronal degeneration by the following day. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 160-164 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 32-35
8561307-2 1995 The excitatory amino acids, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and kainic acid, were applied to area CA1, and the resulting depolarizations were measured using the grease-gap electrophysiological technique. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 83-87 carbonic anhydrase 1 Rattus norvegicus 127-130
8637423-1 1996 Infusion of the excitotoxins, ibotenic acid, quisqualic acid, or AMPA, into the medial septal nucleus, diagonal band, and the nucleus basalis magnocellularis of rats produced less cholinergic cell loss as assessed by choline acetyltransferase activity in the projection fields, cortex and hippocampus, than that obtainable by intraventricular administration of the immunotoxin, 192 IgG-saporin. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 65-69 choline O-acetyltransferase Rattus norvegicus 217-242
8845939-4 1995 In addition, the glutamate receptor agonists (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrobromide (AMPA) and kainate strongly induced c-fos. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 122-126 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 157-162
7595547-0 1995 Basic fibroblast growth factor selectively increases AMPA-receptor subunit GluR1 protein level and differentially modulates Ca2+ responses to AMPA and NMDA in hippocampal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 53-57 fibroblast growth factor 2 Rattus norvegicus 0-30
7595547-0 1995 Basic fibroblast growth factor selectively increases AMPA-receptor subunit GluR1 protein level and differentially modulates Ca2+ responses to AMPA and NMDA in hippocampal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 53-57 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 75-80
7613609-4 1995 The reticular nucleus of the thalamus, a structure known to be highly susceptible to AMPA-induced neurotoxicity, expressed GluR4 immunoreactivity exclusively. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 85-89 glutamate ionotropic receptor AMPA type subunit 4 Rattus norvegicus 123-128
7559406-4 1995 AMPA, but not NMDA, caused an association of a G-protein beta subunit with a Ras, Raf kinase, and MAP/ERK kinase (MEK)-1 complex. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 mitogen activated protein kinase kinase 1 Rattus norvegicus 102-120
7542123-3 1995 AMPA-induced basal forebrain lesions destroyed significantly more neurons that expressed choline acetyltransferase mRNA than ibotenic acid-induced lesions (90 versus 60%), but significantly fewer neurons which expressed either glutamate decarboxylase or preproenkephalin mRNA (61 versus 83% reduction in glutamate decarboxylase mRNA and 56 versus 79% reduction in preproenkephalin mRNA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 choline O-acetyltransferase Rattus norvegicus 89-114
7542123-3 1995 AMPA-induced basal forebrain lesions destroyed significantly more neurons that expressed choline acetyltransferase mRNA than ibotenic acid-induced lesions (90 versus 60%), but significantly fewer neurons which expressed either glutamate decarboxylase or preproenkephalin mRNA (61 versus 83% reduction in glutamate decarboxylase mRNA and 56 versus 79% reduction in preproenkephalin mRNA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 glutamate-ammonia ligase Rattus norvegicus 227-250
7542123-3 1995 AMPA-induced basal forebrain lesions destroyed significantly more neurons that expressed choline acetyltransferase mRNA than ibotenic acid-induced lesions (90 versus 60%), but significantly fewer neurons which expressed either glutamate decarboxylase or preproenkephalin mRNA (61 versus 83% reduction in glutamate decarboxylase mRNA and 56 versus 79% reduction in preproenkephalin mRNA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 glutamate-ammonia ligase Rattus norvegicus 304-327
7551191-2 1995 Stimulation of afferents in the CA1 area of lesioned hippocampi produced an epileptiform burst of action potentials, with an underlying synaptic potential composed of mixed alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA; 80%) and N-methyl-D-aspartate (NMDA; 20%) receptor-mediated components. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 227-231 carbonic anhydrase 1 Rattus norvegicus 32-35
7544224-4 1995 The present study investigated whether alpha-2-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) or N-methyl-D-aspartate (NMDA) differentially destroy NKB-containing, NKB-receptive, or cholinergic NBM cells, and whether this vulnerability is altered by aging. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 100-104 tachykinin precursor 3 Rattus norvegicus 160-163
7969894-3 1994 We used in situ hybridization to examine GluR1, GluR2, and GluR3 messengerRNAs (encoding alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid/kainate receptor subunits) in sections of autopsy samples of Alzheimer"s disease brains and age-, sex-, and post-mortem delay-matched brains from non-demented (control) subjects. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 89-146 glutamate ionotropic receptor AMPA type subunit 3 Homo sapiens 59-64
7589322-3 1995 For each cell, a level of current was found for the iontophoretic ejection of the NMDA antagonist AP5 that blocked responses elicited by iontophoresis of NMDA, but had no effect on responses elicited by AMPA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 203-207 adaptor related protein complex 5 subunit beta 1 Homo sapiens 98-101
7529639-7 1994 TRH also markedly enhanced the depolarizing responses evoked by iontophoretically applied N-methyl-D-aspartate (NMDA), while the depolarizing responses evoked by (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) and L-glutamate were not significantly affected. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 227-231 thyrotropin releasing hormone Rattus norvegicus 0-3
7544323-7 1995 In this paper, we present data indicating that hippocampal astrocytes in situ respond to glutamate, kainate, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), 1-aminocyclopentane-trans-1,3-dicarboxylic acid (t-ACPD), N-methyl-D-aspartate (NMDA), and depolarization with increases in [Ca2+]i. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 167-171 homer scaffold protein 2 Homo sapiens 225-229
7874236-4 1994 In addition, KCl-induced LTP was associated with an increase in 3H-AMPA ([3H]-amino-3-hydroxy-5-methylisoxazole-4-propionate) binding to CA1 synaptic membranes when measured 40 min after high-potassium exposure; however, no changes were detected in binding of an antagonist ([3H]-6-cyano-7-nitroquinoxaline-2,3-dione; 3H-CNQX) to AMPA receptors in slices expressing KCl-induced LTP. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 78-124 carbonic anhydrase 1 Homo sapiens 137-140
8288598-8 1994 Immunoprecipitation studies showed that antibodies to GluR6 and KA2 selectively immunoprecipitated [3H]kainate binding activity, but not 3H-labeled alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) binding activity, from Triton X-100-solubilized rat brain membranes. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 208-212 glutamate ionotropic receptor kainate type subunit 2 Rattus norvegicus 54-59
8087094-6 1994 In contrast, glutamate and different glutamate agonists such as NMDA, AMPA and kainate, can increase LHRH/LH secretion. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 70-74 gonadotropin releasing hormone 1 Homo sapiens 101-105
7515817-3 1994 Systemic administration of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-selective antagonist 6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3(1H,4H)-dione (NBQX) increased DOPAC concentrations in the median eminence and intermediate lobe, and decreased plasma concentrations of prolactin and alpha-MSH, in a dose- and time-related manner. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 89-93 proopiomelanocortin Rattus norvegicus 310-319
8288598-8 1994 Immunoprecipitation studies showed that antibodies to GluR6 and KA2 selectively immunoprecipitated [3H]kainate binding activity, but not 3H-labeled alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) binding activity, from Triton X-100-solubilized rat brain membranes. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 208-212 glutamate ionotropic receptor kainate type subunit 5 Rattus norvegicus 64-67
7686107-2 1993 The results demonstrate that FOS immunoreactivity (ir) can be detected in ventral and dorsal striatal neurons following infusions of the non-N-methyl-D-aspartic acid (NMDA) glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 259-263 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 29-32
7693886-5 1993 The mu-opioid agonist D-Ala2-MePhe4-Gly-ol5-enkephalin (DAMGO; 1 microM) potentiated the response to bath application of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid by 91 and 142%, respectively, in slices cut in the horizontal plane. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 153-211 proenkephalin Rattus norvegicus 44-54
7681405-0 1993 Mg2+ antagonizes alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced brain damage and convulsions. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 17-73 mucin 7, secreted Homo sapiens 0-3
8124521-8 1993 Although not yet conclusively identified by specific cytochemical markers, the gp120-responsive cells resemble type-2 astrocytes and differ from neurons and type-1 astrocytes both in gross phenotype and in a number of receptor/channel properties: positivity to AMPA and cholinergic agonists; negativity to NMDA, serotonin and high KCl. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 261-265 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 79-84
8450957-1 1993 The messenger RNA expression of non-N-methyl-D-aspartate glutamate receptor subunits (GluR1-4), considered alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid type, was investigated in rat brain by in situ hybridization histochemistry using oligonucleotide probes specific to each subunit sequence. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 107-164 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 86-93
7835247-4 1993 Subtoxic doses of TNF alpha (50 pg/ml) are neurotoxic in combination with the glutamate (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) subtype receptor agonist AMPA (100 microM). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 153-157 tumor necrosis factor Homo sapiens 18-27
7686107-0 1993 Transsynaptic induction of c-fos in basal forebrain, diencephalic and midbrain neurons following AMPA-induced activation of the dorsal and ventral striatum. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 97-101 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 27-32
7686107-2 1993 The results demonstrate that FOS immunoreactivity (ir) can be detected in ventral and dorsal striatal neurons following infusions of the non-N-methyl-D-aspartic acid (NMDA) glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 200-257 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 29-32
7686107-5 1993 By combining the retrograde transport of Fluoro-Gold with FOS immunocytochemistry, it was also possible to demonstrate that approximately 46% and 58% of the pallidal neurons containing FOS-ir after infusions of AMPA into the VS or DS, respectively, directly project to the subthalamic nucleus. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 211-215 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 58-61
7686107-5 1993 By combining the retrograde transport of Fluoro-Gold with FOS immunocytochemistry, it was also possible to demonstrate that approximately 46% and 58% of the pallidal neurons containing FOS-ir after infusions of AMPA into the VS or DS, respectively, directly project to the subthalamic nucleus. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 211-215 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 185-188
7686108-2 1993 The results of experiment 1 showed that N-methyl-D-aspartic acid (NMDA), quisqualic acid and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) differentially increased the expression of c-fos in magnocellular cholinergic nucleus basalis, dorsal and ventral pallidal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 93-150 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 201-206
7686108-3 1993 AMPA was the most, and NMDA the least, effective in inducing FOS in nucleus basalis magnocellularis (nbM) neurons, with quisqualic acid having an intermediate effect, whereas the reverse was true in terms of the induction of FOS in pallidal neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 0-4 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 61-64
1385165-0 1992 Modulation of N-methyl-D-aspartate and (R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) responses of spinal nociceptive neurons by a N-terminal fragment of substance P. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 99-103 tachykinin precursor 1 Homo sapiens 173-184
1330209-5 1992 The QA-mediated increase in glutaminase was mimicked by the ionotropic QA receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA; EC50, about 0.5 microM), but not by the metabotropic QA receptor agonist trans-(+-)-1-amino-cyclopentyl-1,3,dicarboxylate (t-ACPD; up to 0.5 mM). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 91-147 homer scaffold protein 2 Homo sapiens 280-284
1330209-5 1992 The QA-mediated increase in glutaminase was mimicked by the ionotropic QA receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA; EC50, about 0.5 microM), but not by the metabotropic QA receptor agonist trans-(+-)-1-amino-cyclopentyl-1,3,dicarboxylate (t-ACPD; up to 0.5 mM). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 149-153 homer scaffold protein 2 Homo sapiens 280-284
1281252-3 1992 Functional receptors activated by kainate, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and glutamate were expressed in Xenopus oocytes injected with GluR1, GluR2 or a mixture of GluR1 and GluR2 RNAs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 98-102 glutamate receptor, ionotropic, AMPA 1 L homeolog Xenopus laevis 166-171
1281252-3 1992 Functional receptors activated by kainate, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and glutamate were expressed in Xenopus oocytes injected with GluR1, GluR2 or a mixture of GluR1 and GluR2 RNAs. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 98-102 glutamate receptor, ionotropic, AMPA 2 S homeolog Xenopus laevis 173-178
1980647-7 1990 The desensitization of the [Ca2+]i response to kainate was greatly augmented by quisqualate and by the putative ionotropic quisqualate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 152-208 carbonic anhydrase 2 Gallus gallus 28-31
1382799-5 1992 alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) induced accumulations of cobalt in CA1 and hilar neurons 130% above control with an ED50 = 30 microM, but had little effect on dentate granule cells. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 59-63 carbonic anhydrase 1 Homo sapiens 100-103
1311100-6 1992 Xenopus oocytes injected with in vitro-synthesized HBGR1 cRNA expressed currents activated by glutamate receptor agonists with the following specificity sequence: domoate greater than kainate much greater than quisqualate greater than or equal to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid greater than or equal to L-glutamate much greater than N-methyl-D-aspartate. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 247-304 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 51-56
1371217-6 1992 Our data show that the GluR6 and GluR7 subunits have a rank order of agonist affinity (domoate greater than kainate much greater than L-glutamate, quisqualate much greater than AMPA, NMDA) and a dissociation constant for kainate (95 and 77 nM, respectively) characteristic of the low affinity kainate-binding sites described in the brain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 177-181 glutamate ionotropic receptor kainate type subunit 2 Homo sapiens 23-28
1371217-6 1992 Our data show that the GluR6 and GluR7 subunits have a rank order of agonist affinity (domoate greater than kainate much greater than L-glutamate, quisqualate much greater than AMPA, NMDA) and a dissociation constant for kainate (95 and 77 nM, respectively) characteristic of the low affinity kainate-binding sites described in the brain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 177-181 glutamate ionotropic receptor kainate type subunit 3 Homo sapiens 33-38
1724310-3 1991 A strong potentiation of the effect was seen when substance P was coadministered with N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) or kainic acid (KA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 115-172 tachykinin 1 Mus musculus 50-61
1724310-3 1991 A strong potentiation of the effect was seen when substance P was coadministered with N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) or kainic acid (KA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 174-178 tachykinin 1 Mus musculus 50-61
1681587-3 1991 Electrophysiological recordings made in Xenopus oocytes that express DGluR-II revealed depolarizing responses to L-glutamate and L-aspartate but low sensitivity to quisqualate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and kainate. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 231-235 Glutamate receptor IIA Drosophila melanogaster 69-77
1770444-9 1991 The structurally related kainate analogue alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA; 200 nM) depressed the slow Ca2+ current by 30 +/- 7%, an effect also blocked by CNQX. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 96-100 carbonic anhydrase 2 Rattus norvegicus 129-132
1351426-1 1992 Previous results have indicated that phospholipase A2 (PLA2) treatment of telencephalic membranes produced opposite effects on [3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) binding in neonatal and adult rats. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 183-187 phospholipase A2 group IB Rattus norvegicus 37-53
1351426-1 1992 Previous results have indicated that phospholipase A2 (PLA2) treatment of telencephalic membranes produced opposite effects on [3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) binding in neonatal and adult rats. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 183-187 phospholipase A2 group IB Rattus norvegicus 55-59
1933277-8 1991 Glutamate metabotropic binding and AMPA binding were reduced significantly in CA1 in subjects with Alzheimer"s disease whereas kainate binding was minimally altered in this region. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 35-39 carbonic anhydrase 1 Homo sapiens 78-81
1709304-3 1991 Non-NMDA receptor ion channels that can be gated by kainic acid (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) are formed by the glutamate receptor subunits GluR1, GluR2, and GluR3. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 132-136 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 4-17
1709304-3 1991 Non-NMDA receptor ion channels that can be gated by kainic acid (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) are formed by the glutamate receptor subunits GluR1, GluR2, and GluR3. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 132-136 glutamate receptor, ionotropic, AMPA 1 L homeolog Xenopus laevis 184-189
1709304-3 1991 Non-NMDA receptor ion channels that can be gated by kainic acid (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) are formed by the glutamate receptor subunits GluR1, GluR2, and GluR3. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 132-136 glutamate receptor, ionotropic, AMPA 2 S homeolog Xenopus laevis 191-196
1709304-3 1991 Non-NMDA receptor ion channels that can be gated by kainic acid (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) are formed by the glutamate receptor subunits GluR1, GluR2, and GluR3. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 132-136 glutamate receptor, ionotropic, AMPA 3 L homeolog Xenopus laevis 202-207
1980131-7 1990 Trans-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD), a selective agonist for the metabolotropic glutamate receptor, caused a transient elevation of [Ca2+]c, which was blocked by prior exposure to QA but not AMPA. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 216-220 homer scaffold protein 2 Homo sapiens 55-59
1980647-7 1990 The desensitization of the [Ca2+]i response to kainate was greatly augmented by quisqualate and by the putative ionotropic quisqualate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 210-214 carbonic anhydrase 2 Gallus gallus 28-31