PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34868457-18	2021	Furthermore, Tempol or Go 6983 pretreatment decreased ET-1, iNOS, and p-PKC expression and increased eNOS expression in HUVECs.	tempol	13-19	endothelin 1	Mus musculus	54-58
34779863-11	2021	Treatment with tempol in paternal rats also reversed the increased expressions of AT1R and GRK4 in the kidney of their offspring.	tempol	15-21	angiotensin II receptor, type 1a	Rattus norvegicus	82-86
34779863-11	2021	Treatment with tempol in paternal rats also reversed the increased expressions of AT1R and GRK4 in the kidney of their offspring.	tempol	15-21	G protein-coupled receptor kinase 4	Rattus norvegicus	91-95
34868457-18	2021	Furthermore, Tempol or Go 6983 pretreatment decreased ET-1, iNOS, and p-PKC expression and increased eNOS expression in HUVECs.	tempol	13-19	nitric oxide synthase 2, inducible	Mus musculus	60-64
34868457-18	2021	Furthermore, Tempol or Go 6983 pretreatment decreased ET-1, iNOS, and p-PKC expression and increased eNOS expression in HUVECs.	tempol	13-19	nitric oxide synthase 3, endothelial cell	Mus musculus	101-105
35286582-8	2022	However, treatment with 2-APB (SOCE inhibitor), apocynin (NOX inhibitor), or tempol (reactive oxygen species scavenger) significantly reversed these LPS-induced changes, and improved neuronal damage and Abeta deposition.	tempol	77-83	histocompatibility 2, class II antigen A, beta 1	Mus musculus	203-208
34769194-13	2021	Tempol efficiently inhibited 15d-PGJ2-induced ERK1/2 activation, while N-acetylcystein and pyrrolidine dithiocarbamate were less effective.	tempol	0-6	mitogen-activated protein kinase 3	Homo sapiens	46-52
34650666-7	2021	Furthermore, MICAL2 knockdown attenuated intracellular ROS generation, while MICAL2 overexpression led to a decrease in the p-YAP/YAP ratio and promoted YAP nuclear localization and cell proliferation, effects that were reversed by pretreatment with the ROS scavenger N-acetyl-L-cysteine (NAC) and SOD-mimetic drug tempol.	tempol	315-321	microtubule associated monooxygenase, calponin and LIM domain containing 2	Homo sapiens	77-83
34650666-7	2021	Furthermore, MICAL2 knockdown attenuated intracellular ROS generation, while MICAL2 overexpression led to a decrease in the p-YAP/YAP ratio and promoted YAP nuclear localization and cell proliferation, effects that were reversed by pretreatment with the ROS scavenger N-acetyl-L-cysteine (NAC) and SOD-mimetic drug tempol.	tempol	315-321	Yes1 associated transcriptional regulator	Homo sapiens	126-129
34650666-7	2021	Furthermore, MICAL2 knockdown attenuated intracellular ROS generation, while MICAL2 overexpression led to a decrease in the p-YAP/YAP ratio and promoted YAP nuclear localization and cell proliferation, effects that were reversed by pretreatment with the ROS scavenger N-acetyl-L-cysteine (NAC) and SOD-mimetic drug tempol.	tempol	315-321	Yes1 associated transcriptional regulator	Homo sapiens	130-133
34650666-7	2021	Furthermore, MICAL2 knockdown attenuated intracellular ROS generation, while MICAL2 overexpression led to a decrease in the p-YAP/YAP ratio and promoted YAP nuclear localization and cell proliferation, effects that were reversed by pretreatment with the ROS scavenger N-acetyl-L-cysteine (NAC) and SOD-mimetic drug tempol.	tempol	315-321	Yes1 associated transcriptional regulator	Homo sapiens	153-156
35421784-8	2022	However, treatment with Rg1, tempol (a superoxide dismutase mimetic), and apocynin (a NOX inhibitor) significantly improved renal function impairment and renal fibrosis, and significantly decreased the levels of TGF-beta, IL-1beta, KIM-1, beta-Gal, and collagen IV in the kidneys.	tempol	29-35	transforming growth factor alpha	Mus musculus	212-220
35421784-8	2022	However, treatment with Rg1, tempol (a superoxide dismutase mimetic), and apocynin (a NOX inhibitor) significantly improved renal function impairment and renal fibrosis, and significantly decreased the levels of TGF-beta, IL-1beta, KIM-1, beta-Gal, and collagen IV in the kidneys.	tempol	29-35	interleukin 1 alpha	Mus musculus	222-230
35421784-8	2022	However, treatment with Rg1, tempol (a superoxide dismutase mimetic), and apocynin (a NOX inhibitor) significantly improved renal function impairment and renal fibrosis, and significantly decreased the levels of TGF-beta, IL-1beta, KIM-1, beta-Gal, and collagen IV in the kidneys.	tempol	29-35	hepatitis A virus cellular receptor 1	Mus musculus	232-237
35549793-2	2022	The current study provides muscle cell-specific insights into the effect of Tempol on the TRPC 1 channel; on the positive and negative regulators of muscle cell differentiation; on the antioxidant enzymatic system; on the activators of mitochondrial biogenesis; and on the inflammatory process in the dystrophic primary muscle cells in culture.	tempol	76-82	transient receptor potential cation channel subfamily C member 1	Homo sapiens	90-96
34834085-0	2021	In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-beta1/SMAD3/NOX4 Cue.	tempol	52-58	transforming growth factor, beta 1	Rattus norvegicus	123-132
34834085-0	2021	In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-beta1/SMAD3/NOX4 Cue.	tempol	52-58	SMAD family member 3	Rattus norvegicus	133-138
34834085-0	2021	In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-beta1/SMAD3/NOX4 Cue.	tempol	52-58	NADPH oxidase 4	Rattus norvegicus	139-143
34834085-7	2021	The superoxide dismutase mimetic effect of tempol was accompanied by decreased NADPH oxidase 4 (NOX4), inflammatory mediators, nuclear factor-kappa B (NF-kappaB), over-released transforming growth factor-beta1 (TGF-beta1).	tempol	43-49	NADPH oxidase 4	Rattus norvegicus	79-94
34834085-7	2021	The superoxide dismutase mimetic effect of tempol was accompanied by decreased NADPH oxidase 4 (NOX4), inflammatory mediators, nuclear factor-kappa B (NF-kappaB), over-released transforming growth factor-beta1 (TGF-beta1).	tempol	43-49	NADPH oxidase 4	Rattus norvegicus	96-100
34834085-7	2021	The superoxide dismutase mimetic effect of tempol was accompanied by decreased NADPH oxidase 4 (NOX4), inflammatory mediators, nuclear factor-kappa B (NF-kappaB), over-released transforming growth factor-beta1 (TGF-beta1).	tempol	43-49	transforming growth factor, beta 1	Rattus norvegicus	177-209
34834085-7	2021	The superoxide dismutase mimetic effect of tempol was accompanied by decreased NADPH oxidase 4 (NOX4), inflammatory mediators, nuclear factor-kappa B (NF-kappaB), over-released transforming growth factor-beta1 (TGF-beta1).	tempol	43-49	transforming growth factor, beta 1	Rattus norvegicus	211-220
34834085-10	2021	These findings suggest the promising role of tempol in ameliorating MIA-induced knee OA in rats via collateral suppression of the catabolic signaling cascades including TGF-beta1/SMAD3/NOX4, and NOX4/p38MAPK/NF-kappaB and therefore modulation of oxidative stress, catabolic inflammatory cascades, chondrocyte metabolic homeostasis.	tempol	45-51	transforming growth factor, beta 1	Rattus norvegicus	169-178
34834085-10	2021	These findings suggest the promising role of tempol in ameliorating MIA-induced knee OA in rats via collateral suppression of the catabolic signaling cascades including TGF-beta1/SMAD3/NOX4, and NOX4/p38MAPK/NF-kappaB and therefore modulation of oxidative stress, catabolic inflammatory cascades, chondrocyte metabolic homeostasis.	tempol	45-51	SMAD family member 3	Rattus norvegicus	179-184
34834085-10	2021	These findings suggest the promising role of tempol in ameliorating MIA-induced knee OA in rats via collateral suppression of the catabolic signaling cascades including TGF-beta1/SMAD3/NOX4, and NOX4/p38MAPK/NF-kappaB and therefore modulation of oxidative stress, catabolic inflammatory cascades, chondrocyte metabolic homeostasis.	tempol	45-51	NADPH oxidase 4	Rattus norvegicus	185-189
34834085-10	2021	These findings suggest the promising role of tempol in ameliorating MIA-induced knee OA in rats via collateral suppression of the catabolic signaling cascades including TGF-beta1/SMAD3/NOX4, and NOX4/p38MAPK/NF-kappaB and therefore modulation of oxidative stress, catabolic inflammatory cascades, chondrocyte metabolic homeostasis.	tempol	45-51	NADPH oxidase 4	Rattus norvegicus	195-199
34083449-4	2021	Oxidation of the clusters by the stable nitroxide TEMPOL caused their disassembly, potently inhibited the RdRp, and blocked SARS-CoV-2 replication in cell culture.	tempol	50-56	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	106-110
34110719-6	2021	Early and extended increases in CBP were prevented by tempol in the hypercholesterolemia rats, while, in the normocholesterolemic rats, only the extended increase in CBP was affected by tempol; BSO prevented extended increase in CBP in normocholesterolemic rats.	tempol	54-60	CREB binding protein	Rattus norvegicus	32-35
34110719-6	2021	Early and extended increases in CBP were prevented by tempol in the hypercholesterolemia rats, while, in the normocholesterolemic rats, only the extended increase in CBP was affected by tempol; BSO prevented extended increase in CBP in normocholesterolemic rats.	tempol	54-60	CREB binding protein	Rattus norvegicus	229-232
34110719-6	2021	Early and extended increases in CBP were prevented by tempol in the hypercholesterolemia rats, while, in the normocholesterolemic rats, only the extended increase in CBP was affected by tempol; BSO prevented extended increase in CBP in normocholesterolemic rats.	tempol	186-192	CREB binding protein	Rattus norvegicus	32-35
34110719-6	2021	Early and extended increases in CBP were prevented by tempol in the hypercholesterolemia rats, while, in the normocholesterolemic rats, only the extended increase in CBP was affected by tempol; BSO prevented extended increase in CBP in normocholesterolemic rats.	tempol	186-192	CREB binding protein	Rattus norvegicus	166-169
33374943-11	2020	The interstitial angiotensin II was increased in the CMA group but decreased in the CMA with captopril and tempol groups.	tempol	107-113	angiotensinogen	Rattus norvegicus	17-31
33669093-7	2021	Our data suggested that tempol treatment is able to reduce inflammation and nitrite production in LPS-induced J774 as well as reducing the production of proinflammatory mediators including cytokines, enzymes, and metalloproteases (MMPs) in IL-1beta-stimulated CC.	tempol	24-30	interleukin 1 alpha	Homo sapiens	240-248
33688389-10	2021	Treatment with 10 muM TEMPOL or 100 muM apocynin prevented the increase in O2  - formation, ACh-induced vasodilation, P-eNOSS1177, and P-AktS473 observed in response to Panx-1 inhibition.	tempol	22-28	Pannexin 1	Rattus norvegicus	169-175
32909857-8	2021	Accordingly, increased COX-1 and COX-2 expressions by Ang II exposure were corrected by losartan, DPI, or tempol.	tempol	106-112	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	23-28
32909857-8	2021	Accordingly, increased COX-1 and COX-2 expressions by Ang II exposure were corrected by losartan, DPI, or tempol.	tempol	106-112	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	33-38
32909857-8	2021	Accordingly, increased COX-1 and COX-2 expressions by Ang II exposure were corrected by losartan, DPI, or tempol.	tempol	106-112	angiotensinogen	Rattus norvegicus	54-60
32871175-7	2020	It was found that a high dose of tempol almost eliminated TS and protected the cardiac function.	tempol	33-39	thymidylate synthetase	Rattus norvegicus	58-60
32871175-11	2020	This antiapoptotic effect of tempol was similar to that of a control reagent, SB203580, which is a specific inhibitor of phospha-p38 (p-p38).	tempol	29-35	mitogen activated protein kinase 14	Rattus norvegicus	129-132
33098599-9	2020	At the same time, the manganese-superoxide dismutase 2 (SOD2) levels were increased in the tempol-treated group.	tempol	91-97	superoxide dismutase 2, mitochondrial	Mus musculus	22-54
33098599-9	2020	At the same time, the manganese-superoxide dismutase 2 (SOD2) levels were increased in the tempol-treated group.	tempol	91-97	superoxide dismutase 2, mitochondrial	Mus musculus	56-60
33098599-10	2020	In addition, the tempol-treated group showed reduced levels of glutathione-disulphide reductase (GSR), glutathione peroxidase 1 (GPx1) and catalase (CAT) in immunoblots.	tempol	17-23	glutathione peroxidase 1	Mus musculus	103-127
33098599-10	2020	In addition, the tempol-treated group showed reduced levels of glutathione-disulphide reductase (GSR), glutathione peroxidase 1 (GPx1) and catalase (CAT) in immunoblots.	tempol	17-23	glutathione peroxidase 1	Mus musculus	129-133
33098599-10	2020	In addition, the tempol-treated group showed reduced levels of glutathione-disulphide reductase (GSR), glutathione peroxidase 1 (GPx1) and catalase (CAT) in immunoblots.	tempol	17-23	catalase	Mus musculus	139-147
33098599-10	2020	In addition, the tempol-treated group showed reduced levels of glutathione-disulphide reductase (GSR), glutathione peroxidase 1 (GPx1) and catalase (CAT) in immunoblots.	tempol	17-23	catalase	Mus musculus	149-152
33098599-11	2020	The tempol-treated group has also shown lower relative gene expression of SOD1, CAT and GPx than the non-treated group.	tempol	4-10	superoxide dismutase 1, soluble	Mus musculus	74-78
33098599-11	2020	The tempol-treated group has also shown lower relative gene expression of SOD1, CAT and GPx than the non-treated group.	tempol	4-10	catalase	Mus musculus	80-83
33098599-11	2020	The tempol-treated group has also shown lower relative gene expression of SOD1, CAT and GPx than the non-treated group.	tempol	4-10	peroxiredoxin 6 pseudogene 2	Mus musculus	88-91
33098599-12	2020	Our data demonstrated that tempol treatment reduced oxidant parameters and increased anti-oxidant SOD2 levels in the DIA muscle of mdx mice, which may contribute to the normalization of the redox homeostasis of dystrophic muscles.	tempol	27-33	superoxide dismutase 2, mitochondrial	Mus musculus	98-102
32416155-16	2020	The superoxide dismutase mimetic Tempol abolished high glucose-induced p70S6K1 activation.	tempol	33-39	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	71-78
32915316-8	2020	Renal infusion of capsaicin promoted p65-NFkappaB phosphorylation and IL-1beta production in the PVN, which were prevented by PVN microinjection of NADPH oxidase inhibitor apocynin or the superoxide anion scavenger tempol.	tempol	215-221	synaptotagmin 1	Rattus norvegicus	37-40
31825758-5	2019	Results: Pretreatment with Tempol (3 mM) significantly increased cell viability and antioxidant activity as well as decreased reactive oxygen species production, cytokines, PGE2 levels, and COX-2 expression.	tempol	27-33	prostaglandin G/H synthase 2	Oryctolagus cuniculus	190-195
33078650-0	2022	Tempol (4-hydroxy tempo) protects mice from cisplatin-induced acute kidney injury via modulation of expression of aquaporins and kidney injury molecule-1.	tempol	0-6	hepatitis A virus cellular receptor 1	Mus musculus	129-153
33078650-3	2022	We investigated the attenuating effect of tempol against CP-induced alterations in kidney injury molecule-1 (KIM-1) and aquaporins (AQPs) in mice.	tempol	42-48	hepatitis A virus cellular receptor 1	Mus musculus	83-107
33078650-8	2022	In conclusion, this study provides experimental evidence that tempol resolved urinary concentration defect by the restoration of AQP, AVP and KIM-1 levels indicating a potential use of tempol in ameliorating the AKI in cancer patients under the treatment with CP.	tempol	62-68	arginine vasopressin	Homo sapiens	134-137
33078650-8	2022	In conclusion, this study provides experimental evidence that tempol resolved urinary concentration defect by the restoration of AQP, AVP and KIM-1 levels indicating a potential use of tempol in ameliorating the AKI in cancer patients under the treatment with CP.	tempol	62-68	hepatitis A virus cellular receptor 1	Homo sapiens	142-147
33078650-8	2022	In conclusion, this study provides experimental evidence that tempol resolved urinary concentration defect by the restoration of AQP, AVP and KIM-1 levels indicating a potential use of tempol in ameliorating the AKI in cancer patients under the treatment with CP.	tempol	185-191	hepatitis A virus cellular receptor 1	Homo sapiens	142-147
32726580-10	2020	In agreement, total GPx activity increased in lung homogenates of tempol treated animals.	tempol	66-72	peroxiredoxin 6 pseudogene 2	Mus musculus	20-23
32521774-9	2020	Besides, VitE and two other anti-oxidant compounds, Tempol and Resveratrol, were found to inhibit Cx43 HCs in HeLa cells transfectants.	tempol	52-58	gap junction protein alpha 1	Homo sapiens	98-102
31682172-10	2020	Furthermore, Tempol, an antioxidant, attenuated AGT upregulation in HG-treated PTC.	tempol	13-19	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	48-51
31940218-13	2020	Concurrent exposure to TNFalpha and Tempol reversed the effect of TNFalpha on IRE1alpha phosphorylation and Mfn2 protein expression.	tempol	36-42	tumor necrosis factor	Homo sapiens	66-74
31940218-13	2020	Concurrent exposure to TNFalpha and Tempol reversed the effect of TNFalpha on IRE1alpha phosphorylation and Mfn2 protein expression.	tempol	36-42	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	78-87
31940218-13	2020	Concurrent exposure to TNFalpha and Tempol reversed the effect of TNFalpha on IRE1alpha phosphorylation and Mfn2 protein expression.	tempol	36-42	mitofusin 2	Homo sapiens	108-112
31727149-3	2019	We investigated whether tempol (50 mg/kg) presents therapeutic potential in SOD1G93A transgenic mice.	tempol	24-30	superoxide dismutase 1, soluble	Mus musculus	76-80
31727149-10	2019	In addition, the groups treated with tempol showed reduced expression of proinflammatory cytokines (IL1beta and TNFalpha) and a three-fold decrease in the expression of TGFbeta1 at ISS compared with the group treated with vehicle.	tempol	37-43	interleukin 1 alpha	Mus musculus	100-107
31727149-10	2019	In addition, the groups treated with tempol showed reduced expression of proinflammatory cytokines (IL1beta and TNFalpha) and a three-fold decrease in the expression of TGFbeta1 at ISS compared with the group treated with vehicle.	tempol	37-43	tumor necrosis factor	Mus musculus	112-120
31727149-10	2019	In addition, the groups treated with tempol showed reduced expression of proinflammatory cytokines (IL1beta and TNFalpha) and a three-fold decrease in the expression of TGFbeta1 at ISS compared with the group treated with vehicle.	tempol	37-43	transforming growth factor, beta 1	Mus musculus	169-177
31727149-11	2019	CONCLUSIONS: Altogether, our results indicate that treatment with tempol has beneficial effects, delaying the onset of the disease by enhancing neuronal survival and decreasing glial cell reactivity during ALS progression in SOD1G93A mice.	tempol	66-72	superoxide dismutase 1, soluble	Mus musculus	225-229
31514290-11	2019	Consistent with these findings, immunohistochemical analysis revealed that vanin-1 was localized in the renal proximal tubules but not the glomeruli in DS rats receiving a high-salt diet, with the strength attenuated by tempol or eplerenone treatment.	tempol	220-226	vanin 1	Rattus norvegicus	75-82
31091128-8	2019	O2- -stimulated surface NKCC2 expression was blocked by the O2- scavenger tempol (50 microM).	tempol	74-80	solute carrier family 12 member 1	Rattus norvegicus	24-29
31255881-8	2019	The results revealed that the tempol (50 muM) and apocynin (50 muM) treatment significantly decreased generation of ROS, expression of NOX2 and NLRP1-related protein in DEX-treated hippocampal neurons.	tempol	30-36	cytochrome b-245, beta polypeptide	Mus musculus	135-139
31255881-8	2019	The results revealed that the tempol (50 muM) and apocynin (50 muM) treatment significantly decreased generation of ROS, expression of NOX2 and NLRP1-related protein in DEX-treated hippocampal neurons.	tempol	30-36	NLR family, pyrin domain containing 1A	Mus musculus	144-149
31054874-6	2019	Whereas the antioxidants N-acetylcysteine (NAC) and Tempol significantly suppressed the expression of BiP and CHOP, suggesting that ROS generation is an early trigger of Cd-activated ER stress.	tempol	52-58	growth differentiation factor 10	Homo sapiens	102-105
31054874-6	2019	Whereas the antioxidants N-acetylcysteine (NAC) and Tempol significantly suppressed the expression of BiP and CHOP, suggesting that ROS generation is an early trigger of Cd-activated ER stress.	tempol	52-58	DNA damage inducible transcript 3	Homo sapiens	110-114
31281565-4	2019	We administered the oxidative stress inhibitors tempol and apocynin via drinking water to the R1.P1-Apoa2c mouse strain induced to develop mouse apolipoprotein A-II (AApoAII) amyloidosis and found that treatment with oxidative stress inhibitors led to reduction in AApoAII amyloidosis progression compared to an untreated group after 12 weeks, especially in the skin, stomach, and liver.	tempol	48-54	apolipoprotein A-II	Mus musculus	145-164
31092012-8	2019	Tempol, which ablated ONOO- by scavenging superoxide anion, reduced the effects of nicotine on SIRT1 and collagen.	tempol	0-6	sirtuin 1	Mus musculus	95-100
31301730-6	2019	Moreover, tempol inhibited IH-induced apoptosis in pancreatic tissue as evidenced by upregulated Bcl-2 level, and downregulated Bax and cleaved caspase-3 levels.	tempol	10-16	BCL2, apoptosis regulator	Rattus norvegicus	97-102
31301730-6	2019	Moreover, tempol inhibited IH-induced apoptosis in pancreatic tissue as evidenced by upregulated Bcl-2 level, and downregulated Bax and cleaved caspase-3 levels.	tempol	10-16	BCL2 associated X, apoptosis regulator	Rattus norvegicus	128-131
30995881-7	2019	Tempol-treated DJ -1 -/- mice presented higher serum nitrite/nitrate levels than vehicle-treated DJ -1 -/- mice, suggesting a role of the NO system in the high blood pressure of this model.	tempol	0-6	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	15-20
31047988-9	2019	Chronic Tempol treatment abolished oxidative stress and overproduction of ROS, and reduced myocardial hypertrophy and Akt phosphorylation in TG mice.	tempol	8-14	thymoma viral proto-oncogene 1	Mus musculus	118-121
31214044-8	2019	Moreover, tempol treatment decreased pro-apoptotic protein expressions (cleaved caspase-3 and Bax) and increased anti-apoptotic Bcl-2 in liver, as well as reducing apoptotic cells of TUNEL staining, which suggested apoptotic effects of tempol treatment.	tempol	10-16	BCL2-associated X protein	Mus musculus	94-97
31214044-8	2019	Moreover, tempol treatment decreased pro-apoptotic protein expressions (cleaved caspase-3 and Bax) and increased anti-apoptotic Bcl-2 in liver, as well as reducing apoptotic cells of TUNEL staining, which suggested apoptotic effects of tempol treatment.	tempol	10-16	B cell leukemia/lymphoma 2	Mus musculus	128-133
30995881-8	2019	Tempol treatment normalized renal kidney injury marker-1 and malondialdehyde expression as well as blood pressure in DJ -1 -/- mice, but had no effect in wild-type mice.	tempol	0-6	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	117-122
30542084-5	2019	In contrast to our expectations, the treatment of SHRSP with tempol (a superoxide dismutase mimetic) significantly (P < 0.05) increased the TXAS mRNA expression in the superficial glomeruli and did not improve the histological injury or albuminuria, which were both aggravated.	tempol	61-67	thromboxane A synthase 1	Homo sapiens	140-144
30371217-8	2018	Administration of 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl attenuated neointimal growth in wire-injured carotid arteries of Cyp1b1 +/+ mice.	tempol	18-63	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	129-135
30623463-6	2019	When cells were treated with TEMPOL in combination with 100 ng/ml BMP-2 and 200 muM AA, ALP activity significantly increased.	tempol	29-35	bone morphogenetic protein 2	Homo sapiens	66-71
30623463-6	2019	When cells were treated with TEMPOL in combination with 100 ng/ml BMP-2 and 200 muM AA, ALP activity significantly increased.	tempol	29-35	alkaline phosphatase, placental	Homo sapiens	88-91
30052510-4	2019	Despite its side-effects at higher concentrations, Tempol was able to substantially prevent TNF-induced apoptosis and to a somewhat lesser extent TNF-induced necroptosis.	tempol	51-57	tumor necrosis factor	Homo sapiens	92-95
30052510-4	2019	Despite its side-effects at higher concentrations, Tempol was able to substantially prevent TNF-induced apoptosis and to a somewhat lesser extent TNF-induced necroptosis.	tempol	51-57	tumor necrosis factor	Homo sapiens	146-149
30346942-13	2018	The expression of the beta-3 adrenoreceptor was increased in the tempol-treated rats.	tempol	65-71	adrenoceptor beta 3	Rattus norvegicus	22-43
29981238-8	2018	Muscimol, baclofen, telmisartan, valsartan, U-73122, chelerythrine chloride, apocynin or tempol pretreatment significantly suppressed the reduction in intercontraction interval induced by central angiotensin II.	tempol	89-95	angiotensinogen	Rattus norvegicus	196-210
29892894-14	2018	Tempol administration also attenuated oxidative stress and apoptosis in cardiac DDAH1-/- LV tissue and partially alleviated LV remodeling after AMI.	tempol	0-6	dimethylarginine dimethylaminohydrolase 1	Mus musculus	80-85
29513566-7	2018	Interestingly, antioxidant treatments such as N-acetylcysteine and TEMPOL, but not catalase, blocked the clinorotation-mediated activation of ERK1/2.	tempol	67-73	mitogen activated protein kinase 3	Rattus norvegicus	142-148
29458041-7	2018	In addition, TEMPOL treatment blunted H/R-induced cTnI phosphorylation.	tempol	13-19	troponin I3, cardiac type	Rattus norvegicus	50-54
29604595-9	2018	Malondialdehyde (MDA), myeloperoxidase (MPO), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were found to be significantly lower in the MTX + tempol group then in the MTX group; while superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels were found to be higher in the MTX + tempol group than in the MTX group.	tempol	171-177	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	46-72
29480820-4	2018	Here, we fed VhlR200W mice supplemented with Tempol, a small, stable nitroxide molecule and observed that Tempol decreased erythropoietin production, corrected splenomegaly, normalized hematocrit levels, and increased the lifespans of these mice.	tempol	45-51	erythropoietin	Mus musculus	123-137
29480820-4	2018	Here, we fed VhlR200W mice supplemented with Tempol, a small, stable nitroxide molecule and observed that Tempol decreased erythropoietin production, corrected splenomegaly, normalized hematocrit levels, and increased the lifespans of these mice.	tempol	106-112	erythropoietin	Mus musculus	123-137
29480820-6	2018	Thus, a new approach to the treatment of patients with Chuvash polycythemia may include dietary supplementation of Tempol, which decreased Hif2alpha expression and markedly reduced life-threatening erythrocytosis/polycythemia in the VhlR200W mice.	tempol	115-121	endothelial PAS domain protein 1	Homo sapiens	139-148
28480509-7	2018	KEY RESULTS: Ox-LDL, but not LDL, significantly increased ENaC activity in the endothelial cells attached to split-open thoracic aortas, and the increase was inhibited by a lectin-like ox-LDL receptor-1 (LOX-1) antagonist (kappa-carrageenan), an NADPH oxidase inhibitor (apocynin), and a scavenger of ROS (TEMPOL).	tempol	306-312	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	173-202
29311937-6	2017	Pretreatment with tempol completely prevented the cellular apoptosis induced by BD, and recovered the inactivation of AKT, which suggested ROS essentially involved in BD-elicited apoptosis and down-regulation of PI3K/Akt pathway.	tempol	18-24	thymoma viral proto-oncogene 1	Mus musculus	118-121
29307864-7	2018	Inhibition of reactive oxygen species by tempol (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl) reduced blood pressure and increased sodium excretion in PM2.5-treated Sprague-Dawley rats, accompanied by an increase in the low D1 receptor expression, and decreased the hyperphosphorylated D1 receptor and GRK4 expression.	tempol	41-47	G protein-coupled receptor kinase 4	Rattus norvegicus	304-308
29307864-7	2018	Inhibition of reactive oxygen species by tempol (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl) reduced blood pressure and increased sodium excretion in PM2.5-treated Sprague-Dawley rats, accompanied by an increase in the low D1 receptor expression, and decreased the hyperphosphorylated D1 receptor and GRK4 expression.	tempol	49-94	G protein-coupled receptor kinase 4	Rattus norvegicus	304-308
29327381-16	2018	N-Acetyl-cysteine or tempol prevented the decreases in the LC3 II/I ratio and Beclin1 and Atg5 expression and attenuated the increases in LV wall thickness, myocyte diameter and brain natriuretic peptide expression in AAC rats.	tempol	21-27	beclin 1	Rattus norvegicus	78-85
29327381-16	2018	N-Acetyl-cysteine or tempol prevented the decreases in the LC3 II/I ratio and Beclin1 and Atg5 expression and attenuated the increases in LV wall thickness, myocyte diameter and brain natriuretic peptide expression in AAC rats.	tempol	21-27	autophagy related 5	Rattus norvegicus	90-94
29870982-7	2018	Renal expressions of Akt/mTOR and GSK3beta pathways were measured by western blot in I/R mice treated with saline or tempol (50mg/kg) and compared with sham-operated mice.	tempol	117-123	thymoma viral proto-oncogene 1	Mus musculus	21-24
29311937-6	2017	Pretreatment with tempol completely prevented the cellular apoptosis induced by BD, and recovered the inactivation of AKT, which suggested ROS essentially involved in BD-elicited apoptosis and down-regulation of PI3K/Akt pathway.	tempol	18-24	thymoma viral proto-oncogene 1	Mus musculus	217-220
28344126-8	2017	Tempol and related nitroxides decreased NO consumption in ascorbate-replete fluids by scavenging MPO-derived ascorbyl radicals.	tempol	0-6	myeloperoxidase	Homo sapiens	97-100
28826937-0	2017	Tempol improves lipid profile and prevents left ventricular hypertrophy in LDL receptor gene knockout (LDLr-/-) mice on a high-fat diet.	tempol	0-6	low density lipoprotein receptor	Mus musculus	75-87
28826937-0	2017	Tempol improves lipid profile and prevents left ventricular hypertrophy in LDL receptor gene knockout (LDLr-/-) mice on a high-fat diet.	tempol	0-6	low density lipoprotein receptor	Mus musculus	103-107
28826937-2	2017	This study investigated the effects of the nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol) on lipid profile and cardiac morphology in low-density lipoprotein (LDL) receptor gene knockout (LDLr-/-) mice.	tempol	101-107	low density lipoprotein receptor	Mus musculus	152-190
28244682-7	2017	The impaired NO production was related to COX-2 activity and superoxide production since was reversed after celecoxib (10 mumol/l) and tempol (100 mumol/l) treatments, respectively.	tempol	135-141	prostaglandin-endoperoxide synthase 2	Homo sapiens	42-47
29025747-7	2017	In ligated carotid arteries, Ucp2-/- mice, compared with wild-type littermates, exhibited accelerated myointimal formation, which was associated with increased superoxide production and can be attenuated by treatment with antioxidant 4-hydroxy-2,2,6,6-tetramethyl-piperidinoxyl (TEMPOL).	tempol	234-277	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	29-33
29025747-7	2017	In ligated carotid arteries, Ucp2-/- mice, compared with wild-type littermates, exhibited accelerated myointimal formation, which was associated with increased superoxide production and can be attenuated by treatment with antioxidant 4-hydroxy-2,2,6,6-tetramethyl-piperidinoxyl (TEMPOL).	tempol	279-285	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	29-33
28633109-6	2017	This MR clustering was blocked by MR disruptor (MCD), ROS scavenger (Tempol) and TXNIP inhibitor (verapamil), accompanied by attenuation of 7-Keto or ChC-induced increase in caspase-1 activity.	tempol	69-75	caspase 1	Mus musculus	174-183
28423286-4	2017	Catalase levels were significantly lower in the I/R group than in the I/R + tempol 30 mg/kg i.p.	tempol	76-82	catalase	Rattus norvegicus	0-8
28532685-4	2017	RESULTS: In the presence of Tempol (5-120 muM), the reductase activity of PDI was reversibly affected both in vitro and in activated mice neutrophils, with an IC50 of 22.9 +- 10.8 muM.	tempol	28-34	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	74-77
28388365-7	2017	In conclusion, tempol and telmisartan are promising drugs in managing cognitive impairment and amyloidogenesis, at least via upregulation of BDNF with inhibition of neuroinflammation and oxido-nitrosative stress.	tempol	15-21	brain derived neurotrophic factor	Mus musculus	141-145
28467798-6	2017	Furthermore, tempol showed a strong inhibiting effect to the p38MAPK-SGK1 pathway similar to SB203580 suggesting that oxidative stress exacerbates EAE via the activation of p38MAPK-SGK1 pathway.	tempol	13-19	mitogen-activated protein kinase 14	Mus musculus	61-68
28467798-6	2017	Furthermore, tempol showed a strong inhibiting effect to the p38MAPK-SGK1 pathway similar to SB203580 suggesting that oxidative stress exacerbates EAE via the activation of p38MAPK-SGK1 pathway.	tempol	13-19	serum/glucocorticoid regulated kinase 1	Mus musculus	69-73
28467798-6	2017	Furthermore, tempol showed a strong inhibiting effect to the p38MAPK-SGK1 pathway similar to SB203580 suggesting that oxidative stress exacerbates EAE via the activation of p38MAPK-SGK1 pathway.	tempol	13-19	mitogen-activated protein kinase 14	Mus musculus	173-180
28467798-6	2017	Furthermore, tempol showed a strong inhibiting effect to the p38MAPK-SGK1 pathway similar to SB203580 suggesting that oxidative stress exacerbates EAE via the activation of p38MAPK-SGK1 pathway.	tempol	13-19	serum/glucocorticoid regulated kinase 1	Mus musculus	181-185
29062837-10	2017	Contralateral carotid exhibited an increased endothelin-1-induced calcium mobilization, which was restored by BQ-788 or Tempol.	tempol	120-126	endothelin 1	Rattus norvegicus	45-57
28397867-6	2017	Metabolic changes and the hypertensive effect of the combined fructose-salt diet (20 weeks) were markedly reversed by a superoxide scavenger, Tempol (10 mg/kg, gavage); moreover, Tempol (50 mM) potentially reduced ROS production and abolished nuclear factor-kappa B (NF-kappaB) activation in human embryonic kidney HEK293 cells incubated with L-fructose (30 mM) and NaCl (500 mosmol/kg added).	tempol	142-148	nuclear factor kappa B subunit 1	Homo sapiens	243-265
28397867-6	2017	Metabolic changes and the hypertensive effect of the combined fructose-salt diet (20 weeks) were markedly reversed by a superoxide scavenger, Tempol (10 mg/kg, gavage); moreover, Tempol (50 mM) potentially reduced ROS production and abolished nuclear factor-kappa B (NF-kappaB) activation in human embryonic kidney HEK293 cells incubated with L-fructose (30 mM) and NaCl (500 mosmol/kg added).	tempol	142-148	nuclear factor kappa B subunit 1	Homo sapiens	267-276
27525680-2	2016	To develop an efficacious and safe nanotherapy against IBD, we designed and developed a superoxide dismutase/catalase mimetic nanomedicine comprising a hydrogen peroxide-eliminating nanomatrix and a free radical scavenger Tempol (Tpl).	tempol	222-228	catalase	Mus musculus	109-117
28203527-12	2016	Angiotensin II increased PKC activity in vehicle-treated cells that further increased in DETC-treated cells, which was attenuated by AT1R blocker candesartan and SOD-mimetic tempol.	tempol	174-180	angiotensinogen	Homo sapiens	0-14
29786208-9	2016	The clearer skin flaps structure, lighter inflammation reaction and inflammation cell infiltration, and higher VEGF staining intensity were observed in the Tempol group than the control group after 7 days.	tempol	156-162	vascular endothelial growth factor A	Rattus norvegicus	111-115
29786208-11	2016	SOD significantly increased, but MDA, TNF-alpha, and IL-6 contents significantly decreased in the Tempol group when compared with control group after 1, 3, and 7 days (P&lt;0.05).	tempol	98-104	tumor necrosis factor	Rattus norvegicus	38-47
29786208-11	2016	SOD significantly increased, but MDA, TNF-alpha, and IL-6 contents significantly decreased in the Tempol group when compared with control group after 1, 3, and 7 days (P&lt;0.05).	tempol	98-104	interleukin 6	Rattus norvegicus	53-57
27525680-2	2016	To develop an efficacious and safe nanotherapy against IBD, we designed and developed a superoxide dismutase/catalase mimetic nanomedicine comprising a hydrogen peroxide-eliminating nanomatrix and a free radical scavenger Tempol (Tpl).	tempol	230-233	catalase	Mus musculus	109-117
27078869-3	2016	This study tested the hypothesis that XOR contributes to the cardiovascular effects of nitrite in renovascular hypertension, and that treatment with the antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) improves XOR-mediated effects of nitrite.	tempol	165-171	xanthine dehydrogenase	Rattus norvegicus	230-233
27489120-5	2016	Treatment with tempol suppressed the nuclear concentration of nuclear factor-kappaB (NF-kappaB) and reduced the renal levels of macrophage chemoattractant protein 1 (MCP-1) and interleukin-6 (IL-6).	tempol	15-21	C-C motif chemokine ligand 2	Rattus norvegicus	128-164
27489120-5	2016	Treatment with tempol suppressed the nuclear concentration of nuclear factor-kappaB (NF-kappaB) and reduced the renal levels of macrophage chemoattractant protein 1 (MCP-1) and interleukin-6 (IL-6).	tempol	15-21	C-C motif chemokine ligand 2	Rattus norvegicus	166-171
27489120-5	2016	Treatment with tempol suppressed the nuclear concentration of nuclear factor-kappaB (NF-kappaB) and reduced the renal levels of macrophage chemoattractant protein 1 (MCP-1) and interleukin-6 (IL-6).	tempol	15-21	interleukin 6	Rattus norvegicus	177-190
27489120-5	2016	Treatment with tempol suppressed the nuclear concentration of nuclear factor-kappaB (NF-kappaB) and reduced the renal levels of macrophage chemoattractant protein 1 (MCP-1) and interleukin-6 (IL-6).	tempol	15-21	interleukin 6	Rattus norvegicus	192-196
27630573-6	2016	TRPC6 activation by 20-HETE was eliminated in cells pretreated with TEMPOL, a membrane-permeable superoxide dismutase mimic.	tempol	68-74	transient receptor potential cation channel subfamily C member 6	Homo sapiens	0-5
27529477-6	2016	Tempol, a superoxide scavenger, mimicked the effects of NOS-1 inhibition on inotropism and protein S-nitrosylation; whereas selective NOS-3 inhibitor L-N5-(1-Iminoethyl)ornithine had no effect.	tempol	0-6	nitric oxide synthase 1	Rattus norvegicus	56-61
27519269-4	2016	Addition of tempol, a powerful antioxidant, to the culture medium of proliferating DUX4-transfected myoblasts and FSHD myoblasts reduced the level of DNA damage, suggesting that DNA alterations are mainly due to oxidative stress.	tempol	12-18	double homeobox 4	Homo sapiens	83-87
27078869-3	2016	This study tested the hypothesis that XOR contributes to the cardiovascular effects of nitrite in renovascular hypertension, and that treatment with the antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) improves XOR-mediated effects of nitrite.	tempol	173-220	xanthine dehydrogenase	Rattus norvegicus	230-233
27266195-0	2016	[Effect of MT01/PEN complexes on the expression of osteoprotegerin and receptor activator of nuclear factor kappaB ligand in human osteoblast-like cell line MG63].	tempol	11-15	TNF receptor superfamily member 11b	Homo sapiens	51-66
27044831-12	2016	CONCLUSION: Pretreatment with Tempol has potential hepatoprotective effects against acute liver injury, induced by CCl4, through antioxidant and anti-inflammatory activities.	tempol	30-36	chemokine (C-C motif) ligand 4	Mus musculus	115-119
26789093-1	2016	This study investigated the effect of tempol (a superoxide dismutase mimetic) on renal vasoconstrictor responses to angiotensin II (Ang II) and adrenergic agonists in fructose-fed Sprague-Dawley rats (a model of metabolic syndrome).	tempol	38-44	angiotensinogen	Rattus norvegicus	116-130
26789093-1	2016	This study investigated the effect of tempol (a superoxide dismutase mimetic) on renal vasoconstrictor responses to angiotensin II (Ang II) and adrenergic agonists in fructose-fed Sprague-Dawley rats (a model of metabolic syndrome).	tempol	38-44	angiotensinogen	Rattus norvegicus	132-138
26789093-9	2016	Acute tempol infusion blunted responses to noradrenaline, methoxamine, and Ang II in control rats by 32%, 33%, and 62%, while it blunted responses to noradrenaline and Ang II in F rats by 26% and 32%, respectively (all p &lt; 0.05), compared with their untreated counterparts.	tempol	6-12	angiotensinogen	Rattus norvegicus	75-81
26789093-9	2016	Acute tempol infusion blunted responses to noradrenaline, methoxamine, and Ang II in control rats by 32%, 33%, and 62%, while it blunted responses to noradrenaline and Ang II in F rats by 26% and 32%, respectively (all p &lt; 0.05), compared with their untreated counterparts.	tempol	6-12	angiotensinogen	Rattus norvegicus	168-174
27266195-0	2016	[Effect of MT01/PEN complexes on the expression of osteoprotegerin and receptor activator of nuclear factor kappaB ligand in human osteoblast-like cell line MG63].	tempol	11-15	TNF superfamily member 11	Homo sapiens	71-121
26894882-5	2016	We tested the hypothesis that tempol activates PKC or PI3K/Akt/Nrf2 pathways to transcribe many genes that coordinate endogenous antioxidant defense.	tempol	30-36	thymoma viral proto-oncogene 1	Mus musculus	59-62
25384549-5	2016	Stressful premature senescent phenotypes induced by NaDC3 were markedly ameliorated via treatment with the antioxidants Tiron and Tempol.	tempol	130-136	solute carrier family 13 member 3	Homo sapiens	52-57
27666396-2	2016	The aim of this study was to investigate the expression of eNOS in intimal and medial layer of aorta from rats fed a high salt diet and its modulation by losartan and tempol.	tempol	167-173	nitric oxide synthase 3	Rattus norvegicus	59-63
27666396-7	2016	Losartan and tempol prevented hypertension and changes in the expression of eNOS and AQP-1 of the intimal layer.	tempol	13-19	nitric oxide synthase 3	Rattus norvegicus	76-80
27666396-7	2016	Losartan and tempol prevented hypertension and changes in the expression of eNOS and AQP-1 of the intimal layer.	tempol	13-19	aquaporin 1	Rattus norvegicus	85-90
26894882-5	2016	We tested the hypothesis that tempol activates PKC or PI3K/Akt/Nrf2 pathways to transcribe many genes that coordinate endogenous antioxidant defense.	tempol	30-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
26237245-10	2015	Tempol treatment significantly suppressed 3-NT formation and preserved ZO-1 levels, and led to improvement in neurological outcomes and reduction of BBB leakiness, brain edema, and apoptosis.	tempol	0-6	tight junction protein 1	Homo sapiens	71-75
26397969-8	2015	Administration of tempol in IH rats significantly reduced levels of TNF-alpha, ICAM-1, NF-kappaB and HIF-1alpha compared with the non-tempol-treated group (F=16.936, P&lt;0.001).	tempol	18-24	tumor necrosis factor	Rattus norvegicus	68-77
26397969-8	2015	Administration of tempol in IH rats significantly reduced levels of TNF-alpha, ICAM-1, NF-kappaB and HIF-1alpha compared with the non-tempol-treated group (F=16.936, P&lt;0.001).	tempol	18-24	intercellular adhesion molecule 1	Rattus norvegicus	79-85
26397969-8	2015	Administration of tempol in IH rats significantly reduced levels of TNF-alpha, ICAM-1, NF-kappaB and HIF-1alpha compared with the non-tempol-treated group (F=16.936, P&lt;0.001).	tempol	18-24	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	101-111
26177467-6	2015	We show that Gentian Violet, Brilliant Green and Tempol significantly decrease intracellular superoxide anion levels and inhibit IKKepsilon expression and cell viability.	tempol	49-55	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	129-139
26711814-7	2015	Tempol, YC-1 (HIF-1 inhibitor), and Bay 11-7082 (NF-kappaB inhibitor) suppressed the cycling hypoxia-mediated Bcl-xL induction in vitro and in vivo.	tempol	0-6	BCL2 like 1	Homo sapiens	110-116
26290366-8	2015	In conclusion IL-1beta, TNF-alpha, and IL-6, when infused systemically, caused immediate and partly reversible increases in glomerular permeability, which could be inhibited by the superoxide scavenger tempol, suggesting an important role of ROS in acute cytokine-induced permeability changes in the GFB.	tempol	202-208	interleukin 1 beta	Rattus norvegicus	14-22
26290366-8	2015	In conclusion IL-1beta, TNF-alpha, and IL-6, when infused systemically, caused immediate and partly reversible increases in glomerular permeability, which could be inhibited by the superoxide scavenger tempol, suggesting an important role of ROS in acute cytokine-induced permeability changes in the GFB.	tempol	202-208	tumor necrosis factor	Rattus norvegicus	24-33
26290366-8	2015	In conclusion IL-1beta, TNF-alpha, and IL-6, when infused systemically, caused immediate and partly reversible increases in glomerular permeability, which could be inhibited by the superoxide scavenger tempol, suggesting an important role of ROS in acute cytokine-induced permeability changes in the GFB.	tempol	202-208	interleukin 6	Rattus norvegicus	39-43
26073126-10	2015	Three-week treatment with TEMPOL, a reactive oxygen species (ROS) scavenger, normalized the alterations in the levels of ROS, eNOS, and sGC, as well as in the production of NO and cGMP and vascular function in the arteries of the offspring of LPS-treated dams.	tempol	26-32	nitric oxide synthase 3	Rattus norvegicus	126-130
26291484-6	2015	Finally, we demonstrated that Apocynin (an NADPH oxidase inhibitor) or Tempol (a superoxide dismutase mimetic) treatment inhibited TNFalpha-induced paw mechanical hyperalgesia and neutrophil recruitment (myeloperoxidase activity).	tempol	71-77	tumor necrosis factor	Mus musculus	131-139
26073126-10	2015	Three-week treatment with TEMPOL, a reactive oxygen species (ROS) scavenger, normalized the alterations in the levels of ROS, eNOS, and sGC, as well as in the production of NO and cGMP and vascular function in the arteries of the offspring of LPS-treated dams.	tempol	26-32	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	136-139
26211713-7	2015	The arteriolar wall contains ETA receptors and the adverse effect of ET-1 was prevented by ETA receptor antagonist BQ123, the superoxide scavenger Tempol, the NADPH oxidase inhibitors apocynin and VAS2870, the NOX2-based NADPH oxidase inhibitor gp91 ds-tat, or the p38 kinase inhibitor SB203580.	tempol	147-153	endothelin 1	Homo sapiens	69-73
25928697-5	2015	RESULTS: DS rats manifested an increase in soleus muscle Ang II content, ROS production and phosopho-IkappaBalpha/IkappaBalpha ratio, ARB or tempol reduced ROS and phospho-IkappaBalpha/IkappaBalpha ratio.	tempol	141-147	NFKB inhibitor alpha	Rattus norvegicus	114-126
26000607-5	2015	Unexpectedly, inhibition of ROS by either N-acetyl-L-cysteine (NAC), a peroxide inhibitor, or Tempol, a superoxide inhibitor, increased the annexin V-/propidium iodide (PI)+ early necrotic population in TRAIL-treated cells.	tempol	94-100	annexin A5	Homo sapiens	140-149
26000607-5	2015	Unexpectedly, inhibition of ROS by either N-acetyl-L-cysteine (NAC), a peroxide inhibitor, or Tempol, a superoxide inhibitor, increased the annexin V-/propidium iodide (PI)+ early necrotic population in TRAIL-treated cells.	tempol	94-100	TNF superfamily member 10	Homo sapiens	203-208
26034980-3	2015	We found that tempol, a nitroxide, strongly induces the accumulation of hypoxia-inducible factor (HIF)-1alpha, particularly under conditions of hypoxia.	tempol	14-20	hypoxia inducible factor 1, alpha subunit	Mus musculus	72-109
26100649-11	2015	The results demonstrated that compared with the infrasound exposure group, the expression of Bcl-2 was up-regulated and the expressions of Bax and caspase-3 were down-regulated in rats pretreated with NRbt (40 mg/kg) or tempol (40 mg/kg).	tempol	220-226	BCL2, apoptosis regulator	Rattus norvegicus	93-98
26100649-11	2015	The results demonstrated that compared with the infrasound exposure group, the expression of Bcl-2 was up-regulated and the expressions of Bax and caspase-3 were down-regulated in rats pretreated with NRbt (40 mg/kg) or tempol (40 mg/kg).	tempol	220-226	BCL2 associated X, apoptosis regulator	Rattus norvegicus	139-142
26100649-11	2015	The results demonstrated that compared with the infrasound exposure group, the expression of Bcl-2 was up-regulated and the expressions of Bax and caspase-3 were down-regulated in rats pretreated with NRbt (40 mg/kg) or tempol (40 mg/kg).	tempol	220-226	caspase 3	Rattus norvegicus	147-156
25818249-2	2015	In this study we investigated whether supplementation with TEMPOL inhibits inflammation and atherosclerosis in apoE-/- mice fed a high fat diet (HFD).	tempol	59-65	apolipoprotein E	Mus musculus	111-115
25928697-5	2015	RESULTS: DS rats manifested an increase in soleus muscle Ang II content, ROS production and phosopho-IkappaBalpha/IkappaBalpha ratio, ARB or tempol reduced ROS and phospho-IkappaBalpha/IkappaBalpha ratio.	tempol	141-147	NFKB inhibitor alpha	Rattus norvegicus	114-126
25928697-5	2015	RESULTS: DS rats manifested an increase in soleus muscle Ang II content, ROS production and phosopho-IkappaBalpha/IkappaBalpha ratio, ARB or tempol reduced ROS and phospho-IkappaBalpha/IkappaBalpha ratio.	tempol	141-147	NFKB inhibitor alpha	Rattus norvegicus	114-126
31973399-2	2015	The corresponding linear homopolymer of 4-carboxy-N,N-diphenylaniline-2,2,6,6-tetramethylpiperidin-1-yloxy (PTPA-TEMPO) was then prepared by chemical oxidative polymerization.	tempol	113-118	protein phosphatase 2 phosphatase activator	Homo sapiens	108-112
25733244-14	2015	Tempol per se had no effect on D1R expression or other signaling molecules but prevented BSO-induced oxidative stress, SP3-AP1 upregulation, and D1R dysfunction in both human kidney cells and rats.	tempol	0-6	Sp3 transcription factor	Homo sapiens	119-122
25733244-14	2015	Tempol per se had no effect on D1R expression or other signaling molecules but prevented BSO-induced oxidative stress, SP3-AP1 upregulation, and D1R dysfunction in both human kidney cells and rats.	tempol	0-6	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-126
25734993-5	2015	Vocalizations to colorectal distension and anxiety-like behavior increased after intracolonic zymosan and were inhibited by intra-CeA application of a ROS scavenger (tempol, a superoxide dismutase mimetic).	tempol	166-172	carcinoembryonic antigen gene family 4	Rattus norvegicus	130-133
25734993-8	2015	Intra-CeA application of tempol inhibited the increased activity but had no effect under normal conditions.	tempol	25-31	carcinoembryonic antigen gene family 4	Rattus norvegicus	6-9
25681429-8	2015	The reactive oxygen species (ROS) inhibitors N-acetylcysteine (NAC), diphenyleneiodonium (DPI), and Tempol also diminished MCP-1 upregulation and JNK activation induced by ADP.	tempol	100-106	C-C motif chemokine ligand 2	Rattus norvegicus	123-128
25681429-8	2015	The reactive oxygen species (ROS) inhibitors N-acetylcysteine (NAC), diphenyleneiodonium (DPI), and Tempol also diminished MCP-1 upregulation and JNK activation induced by ADP.	tempol	100-106	mitogen-activated protein kinase 8	Rattus norvegicus	146-149
31973399-5	2015	Furthermore, the PTPA-TEMPO electrode showed superior cycling and rate performances.	tempol	22-27	protein phosphatase 2 phosphatase activator	Homo sapiens	17-21
25109430-8	2015	Furthermore, the deleterious effects of Ang II on renal IR injury, RSNA, and oxidative stress were abolished by pretreatment with tempol.	tempol	130-136	angiogenin	Rattus norvegicus	40-43
26279424-9	2015	Tempol inhibited NF-kappaB mediated inflammation, TGF-beta/Smad3-induced renal fibrosis as well as EGFR and MAPK signaling pathway activation.	tempol	0-6	SMAD family member 3	Mus musculus	59-64
26279424-9	2015	Tempol inhibited NF-kappaB mediated inflammation, TGF-beta/Smad3-induced renal fibrosis as well as EGFR and MAPK signaling pathway activation.	tempol	0-6	epidermal growth factor receptor	Mus musculus	99-103
26279424-10	2015	CONCLUSIONS: Tempol administration attenuated renal injury in CKD mice through NF-kappaB, TGF-beta/Smad3, redox-senstive EGFR activation and c-Raf/MEK/ERK pathways.	tempol	13-19	SMAD family member 3	Mus musculus	99-104
26279424-10	2015	CONCLUSIONS: Tempol administration attenuated renal injury in CKD mice through NF-kappaB, TGF-beta/Smad3, redox-senstive EGFR activation and c-Raf/MEK/ERK pathways.	tempol	13-19	epidermal growth factor receptor	Mus musculus	121-125
26279424-10	2015	CONCLUSIONS: Tempol administration attenuated renal injury in CKD mice through NF-kappaB, TGF-beta/Smad3, redox-senstive EGFR activation and c-Raf/MEK/ERK pathways.	tempol	13-19	v-raf-leukemia viral oncogene 1	Mus musculus	141-146
26279424-10	2015	CONCLUSIONS: Tempol administration attenuated renal injury in CKD mice through NF-kappaB, TGF-beta/Smad3, redox-senstive EGFR activation and c-Raf/MEK/ERK pathways.	tempol	13-19	midkine	Mus musculus	147-150
26279424-10	2015	CONCLUSIONS: Tempol administration attenuated renal injury in CKD mice through NF-kappaB, TGF-beta/Smad3, redox-senstive EGFR activation and c-Raf/MEK/ERK pathways.	tempol	13-19	mitogen-activated protein kinase 1	Mus musculus	151-154
25687731-8	2015	In primary cultures of renal proximal tubular (RPT) cells from lean and obese rats, tempol treatment also increased AT2R, ACE2, and MasR expressions but decreased AT1R and ACE expressions in obese rats.	tempol	84-90	angiotensin II receptor, type 2	Rattus norvegicus	116-120
25687731-8	2015	In primary cultures of renal proximal tubular (RPT) cells from lean and obese rats, tempol treatment also increased AT2R, ACE2, and MasR expressions but decreased AT1R and ACE expressions in obese rats.	tempol	84-90	angiotensin I converting enzyme 2	Rattus norvegicus	122-126
25687731-8	2015	In primary cultures of renal proximal tubular (RPT) cells from lean and obese rats, tempol treatment also increased AT2R, ACE2, and MasR expressions but decreased AT1R and ACE expressions in obese rats.	tempol	84-90	angiotensin II receptor, type 1a	Rattus norvegicus	163-167
25687731-8	2015	In primary cultures of renal proximal tubular (RPT) cells from lean and obese rats, tempol treatment also increased AT2R, ACE2, and MasR expressions but decreased AT1R and ACE expressions in obese rats.	tempol	84-90	angiotensin I converting enzyme	Rattus norvegicus	122-125
25237191-8	2014	The latter process was inhibited by tempol, which recombines with the hSOD1-derived tryptophanyl radical, and did not occur in the absence of bicarbonate or with enzymes that lack the Trp(32) residue (bovine SOD1 and hSOD1(W32F) mutant).	tempol	36-42	superoxide dismutase 1	Homo sapiens	70-75
25307720-8	2014	Moreover, PVN pre-treatment with tempol or losartan prevented superoxide anions increase caused by Ang II in IR rats.	tempol	33-39	angiotensinogen	Rattus norvegicus	99-105
23386285-7	2014	Tempol treatment reduced oxidative stress and attenuated the changes induced by losartan in the glomerular filtration rate, desmin expression at the glomerular edge, vimentin in tubular cells, as well as apoptosis and inflammatory infiltration in the renal cortex.	tempol	0-6	desmin	Rattus norvegicus	124-130
23386285-7	2014	Tempol treatment reduced oxidative stress and attenuated the changes induced by losartan in the glomerular filtration rate, desmin expression at the glomerular edge, vimentin in tubular cells, as well as apoptosis and inflammatory infiltration in the renal cortex.	tempol	0-6	vimentin	Rattus norvegicus	166-174
25237191-8	2014	The latter process was inhibited by tempol, which recombines with the hSOD1-derived tryptophanyl radical, and did not occur in the absence of bicarbonate or with enzymes that lack the Trp(32) residue (bovine SOD1 and hSOD1(W32F) mutant).	tempol	36-42	superoxide dismutase [Cu-Zn]	Bos taurus	71-75
25237191-8	2014	The latter process was inhibited by tempol, which recombines with the hSOD1-derived tryptophanyl radical, and did not occur in the absence of bicarbonate or with enzymes that lack the Trp(32) residue (bovine SOD1 and hSOD1(W32F) mutant).	tempol	36-42	superoxide dismutase 1	Homo sapiens	217-222
25015976-11	2014	The effects of ROS and PKC-delta were confirmed with patch-clamp experiments on isolated ATII cells in which the ROS scavenger, Tempol, or a PKC-delta-specific inhibitor added to patches reversed the observed decrease in ENaC apical channel density and Po.	tempol	128-134	protein kinase C, delta	Mus musculus	23-32
25271439-9	2014	Moreover, pretreatment with tempol notably inhibited cisplatin-induced oxidative stress and disruption of mitochondrial function by restoring mitochondrial oxidative phosphorylation, complexes I and III activities, mNOS protein expression and ATP content.	tempol	28-34	nitric oxide synthase 1, neuronal	Mus musculus	215-219
25015976-11	2014	The effects of ROS and PKC-delta were confirmed with patch-clamp experiments on isolated ATII cells in which the ROS scavenger, Tempol, or a PKC-delta-specific inhibitor added to patches reversed the observed decrease in ENaC apical channel density and Po.	tempol	128-134	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	221-225
25044374-8	2014	The Cu,Zn-SOD activity and SA concentrations were lower in both mimetically aged and tempol-administered Drosophila groups compared to control (P &lt; 0.05), whereas there were no significantly difference between mimetically aged and tempol-administered groups.	tempol	85-91	Superoxide dismutase 1	Drosophila melanogaster	4-13
24591154-7	2014	The Seahorse data were further supported by electron microscopy (EM) studies in which P16 cells exposed to AZT/ddI/Tempol had less mitochondrial pathology than P16 cells exposed to AZT/ddI.	tempol	115-121	cyclin dependent kinase inhibitor 2A	Homo sapiens	86-89
24490696-6	2014	Tempol inhibited the expression of vascular adhesion molecule 1 (VCAM-1) in aorta and reduced the development of atheroma plaques.	tempol	0-6	vascular cell adhesion molecule 1	Mus musculus	35-63
24490696-6	2014	Tempol inhibited the expression of vascular adhesion molecule 1 (VCAM-1) in aorta and reduced the development of atheroma plaques.	tempol	0-6	vascular cell adhesion molecule 1	Mus musculus	65-71
24591154-8	2014	Western blots of P5 cells showed that Tempol and Tempol-H upregulated expression of mitochondrial uncoupling protein-2 (UCP-2).	tempol	49-55	uncoupling protein 2	Homo sapiens	84-118
24591154-8	2014	Western blots of P5 cells showed that Tempol and Tempol-H upregulated expression of mitochondrial uncoupling protein-2 (UCP-2).	tempol	49-55	uncoupling protein 2	Homo sapiens	120-125
25122005-7	2014	Angiotensin-II-induced ERK1/2 activation was also blocked by Tempol, a scavenger of reactive oxygen species, and correlated with increased Nox4 protein expression.	tempol	61-67	mitogen-activated protein kinase 3	Mus musculus	23-29
25120275-9	2014	The proportion of CD4 lymphocytes in the blood of aged tempol-treated mice was partially increased in comparison to aged control mice.	tempol	55-61	CD4 antigen	Mus musculus	18-21
24590923-7	2014	Losartan or tempol enhanced further the diuresis, and AQP-2 and eNOS expression, as well as decreased Ang II and NF-kB expression.	tempol	12-18	aquaporin 2	Rattus norvegicus	54-59
24590923-7	2014	Losartan or tempol enhanced further the diuresis, and AQP-2 and eNOS expression, as well as decreased Ang II and NF-kB expression.	tempol	12-18	nitric oxide synthase 3	Rattus norvegicus	64-68
24590923-7	2014	Losartan or tempol enhanced further the diuresis, and AQP-2 and eNOS expression, as well as decreased Ang II and NF-kB expression.	tempol	12-18	angiotensinogen	Rattus norvegicus	102-108
24590923-7	2014	Losartan or tempol enhanced further the diuresis, and AQP-2 and eNOS expression, as well as decreased Ang II and NF-kB expression.	tempol	12-18	nuclear factor kappa B subunit 1	Rattus norvegicus	113-118
24590923-9	2014	Importantly, our data also show that losartan and tempol induces a predominantly accumulation of AQP-2 in intracellular vesicles.	tempol	50-56	aquaporin 2	Rattus norvegicus	97-102
24591154-8	2014	Western blots of P5 cells showed that Tempol and Tempol-H upregulated expression of mitochondrial uncoupling protein-2 (UCP-2).	tempol	38-44	uncoupling protein 2	Homo sapiens	84-118
24591154-8	2014	Western blots of P5 cells showed that Tempol and Tempol-H upregulated expression of mitochondrial uncoupling protein-2 (UCP-2).	tempol	38-44	uncoupling protein 2	Homo sapiens	120-125
24145329-11	2014	Tempol, a membrane-permeable radical scavenger, similarly decreased oxidized SERCA2a levels, restored SERCA2a activity, and markedly reduced ER stress response in the mice treated with ISO.	tempol	0-6	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	77-84
24576725-1	2014	AIMS: To explore whether reactive oxygen species (ROS) scavenger (tempol) in the hypothalamic paraventricular nucleus (PVN) attenuates renin-angiotensin system (RAS) and proinflammatory cytokines (PICs), and decreases the blood pressure and sympathetic activity in angiotensin II (ANG II)-induced hypertension.	tempol	66-72	angiotensinogen	Rattus norvegicus	265-279
24576725-1	2014	AIMS: To explore whether reactive oxygen species (ROS) scavenger (tempol) in the hypothalamic paraventricular nucleus (PVN) attenuates renin-angiotensin system (RAS) and proinflammatory cytokines (PICs), and decreases the blood pressure and sympathetic activity in angiotensin II (ANG II)-induced hypertension.	tempol	66-72	angiotensinogen	Rattus norvegicus	281-287
24576725-6	2014	Treatment with PVN infusion of TEMP attenuated the overexpression of gp91(phox), ACE and IL-1beta within the PVN, and decreased sympathetic activity and MAP in ANG II-infused rats.	tempol	31-35	angiotensin I converting enzyme	Rattus norvegicus	81-84
24576725-6	2014	Treatment with PVN infusion of TEMP attenuated the overexpression of gp91(phox), ACE and IL-1beta within the PVN, and decreased sympathetic activity and MAP in ANG II-infused rats.	tempol	31-35	interleukin 1 beta	Rattus norvegicus	89-97
24576725-6	2014	Treatment with PVN infusion of TEMP attenuated the overexpression of gp91(phox), ACE and IL-1beta within the PVN, and decreased sympathetic activity and MAP in ANG II-infused rats.	tempol	31-35	angiotensinogen	Rattus norvegicus	160-166
24586264-0	2014	Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria.	tempol	0-6	coagulation factor III	Mus musculus	47-60
24586264-7	2014	In dendritic cells, Tempol inhibited LPS-induced production of TNF-alpha, IL-6, and IL-12p70, downregulated expression of co-stimulatory molecules, and prevented antigen-dependent lymphocyte proliferation.	tempol	20-26	tumor necrosis factor	Mus musculus	63-72
24586264-7	2014	In dendritic cells, Tempol inhibited LPS-induced production of TNF-alpha, IL-6, and IL-12p70, downregulated expression of co-stimulatory molecules, and prevented antigen-dependent lymphocyte proliferation.	tempol	20-26	interleukin 6	Mus musculus	74-78
24140862-5	2014	In vitro, confocal microscopy and size-exclusion chromatography demonstrated that dismutation of O2(-) by 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol) and decomposition of H2O2 by catalase prevented Hcys-induced aggregation of NLRP3 inflammasome proteins and inhibited Hcys-induced caspase-1 activation and IL-1beta production in mouse podocytes.	tempol	154-160	caspase 1	Mus musculus	293-302
24140862-5	2014	In vitro, confocal microscopy and size-exclusion chromatography demonstrated that dismutation of O2(-) by 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol) and decomposition of H2O2 by catalase prevented Hcys-induced aggregation of NLRP3 inflammasome proteins and inhibited Hcys-induced caspase-1 activation and IL-1beta production in mouse podocytes.	tempol	154-160	interleukin 1 beta	Mus musculus	318-326
24550650-5	2014	The expression of PI3K, phosphorylated Akt, and phosphorylated FoxO3a markedly decreased in tempol-treated mice compared with control mice.	tempol	92-98	thymoma viral proto-oncogene 1	Mus musculus	39-42
24550650-5	2014	The expression of PI3K, phosphorylated Akt, and phosphorylated FoxO3a markedly decreased in tempol-treated mice compared with control mice.	tempol	92-98	forkhead box O3	Mus musculus	63-69
24550650-7	2014	Significantly less apoptosis, a lower ratio of Bax to Bcl-2 expression and fewer apoptotic cells in TUNEL staining, and decreased expression of transforming growth factor-beta1 were observed in the obstructed kidneys from tempol-treated mice compared with those from control mice.	tempol	222-228	BCL2-associated X protein	Mus musculus	47-50
24550650-7	2014	Significantly less apoptosis, a lower ratio of Bax to Bcl-2 expression and fewer apoptotic cells in TUNEL staining, and decreased expression of transforming growth factor-beta1 were observed in the obstructed kidneys from tempol-treated mice compared with those from control mice.	tempol	222-228	B cell leukemia/lymphoma 2	Mus musculus	54-59
24550650-7	2014	Significantly less apoptosis, a lower ratio of Bax to Bcl-2 expression and fewer apoptotic cells in TUNEL staining, and decreased expression of transforming growth factor-beta1 were observed in the obstructed kidneys from tempol-treated mice compared with those from control mice.	tempol	222-228	transforming growth factor, beta 1	Mus musculus	144-176
24550650-8	2014	Tempol attenuates oxidative stress, inflammation, and fibrosis in the obstructed kidneys of UUO mice, and the modulation of PI3K-Akt-FoxO3a signaling may be involved in this pathogenesis.	tempol	0-6	thymoma viral proto-oncogene 1	Mus musculus	129-132
24550650-8	2014	Tempol attenuates oxidative stress, inflammation, and fibrosis in the obstructed kidneys of UUO mice, and the modulation of PI3K-Akt-FoxO3a signaling may be involved in this pathogenesis.	tempol	0-6	forkhead box O3	Mus musculus	133-139
24213617-6	2014	Tempol (1 mmol/l) decreased expression of miR-145 in Wistar and GK rat aorta.	tempol	0-6	microRNA 145	Rattus norvegicus	42-49
24296301-9	2014	Antioxidant treatments (deferoxamine mesylate, (+-)alpha-tocopherol, or tempol) suppressed BDE-47-stimulated IL-6 release by 54.1%, 56.3% and 37.7%, respectively, implicating a role for ROS in the regulation of inflammatory pathways in HTR-8/SVneo cells.	tempol	72-78	interleukin 6	Homo sapiens	109-113
24304537-7	2014	Furthermore, the inhibitory effect of cilostazol on nerve growth factor was reversed by 8-cyclopentyl-1,3-dipropylxanthine, a selective A1 receptor antagonist, and enhanced by tempol administration.	tempol	176-182	nerve growth factor	Rattus norvegicus	52-71
24145329-11	2014	Tempol, a membrane-permeable radical scavenger, similarly decreased oxidized SERCA2a levels, restored SERCA2a activity, and markedly reduced ER stress response in the mice treated with ISO.	tempol	0-6	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	102-109
23949118-8	2013	Tempol treatment significantly corrected the changes in the cardiac extracellular matrix, TGF-beta, ROS or serum LDH, CK-MB levels, and normalized MMP-2 activity along with preservation of cardiac tissues integrity of diabetic rats against damaging responses.	tempol	0-6	transforming growth factor, beta 1	Rattus norvegicus	90-98
23949118-8	2013	Tempol treatment significantly corrected the changes in the cardiac extracellular matrix, TGF-beta, ROS or serum LDH, CK-MB levels, and normalized MMP-2 activity along with preservation of cardiac tissues integrity of diabetic rats against damaging responses.	tempol	0-6	matrix metallopeptidase 2	Rattus norvegicus	147-152
24060804-6	2013	The elevated plasma levels of thiobarbituric acid reactive substances and MMP-9 levels in the SHR were significantly decreased by Tempol treatment (P&lt;0.05).	tempol	130-136	matrix metallopeptidase 9	Rattus norvegicus	74-79
23992296-9	2013	Ang II-stimulated BMP4 expression was inhibited by boldine, tempol, noggin or losartan.	tempol	60-66	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
23992296-9	2013	Ang II-stimulated BMP4 expression was inhibited by boldine, tempol, noggin or losartan.	tempol	60-66	bone morphogenetic protein 4	Mus musculus	18-22
24400151-7	2013	Tempol, a scavenger of superoxide, did not affect responses in adult or old wild-type mice, but restored vasodilation to acetylcholine to normal in old IL-10-deficient mice.	tempol	0-6	interleukin 10	Mus musculus	152-157
24048198-7	2013	Treatment with Tempol, a superoxide scavenger, attenuates the augmented sodium sensitivity in collectrin knockout mice.	tempol	15-21	collectrin, amino acid transport regulator	Mus musculus	94-104
23910436-5	2013	When tempol and catalase were co-infused to reduce both ROS and hydrogen peroxide (H2 O2 ), respectively, there was a significantly greater attenuation of the RNS-evoked reduction in CBP compared with that of tempol alone.	tempol	5-11	CREB binding protein	Rattus norvegicus	183-186
23871345-6	2013	Microinjection of Ang II into the IML dose-dependently elevated mean blood pressure (MAP, employing a transducer-tipped catheter) and renal sympathetic nerve activity (RSNA, using a pair of platinum-iridium recording electrodes), which were completely abolished by Losartan, and attenuated by TEMPOL and apocynin.	tempol	293-299	angiogenin	Rattus norvegicus	18-21
22392697-8	2013	Furthermore, in the cell lines with the K-ras oncogene, overexpression of superoxide dismutases that detoxify non-mitochondrial sources of O 2.-, and treatment with the small molecule O 2.- scavenger Tempol, also decreased hydroethidine fluorescence, inhibited clonogenic survival and inhibited growth of tumor xenografts.	tempol	200-206	KRAS proto-oncogene, GTPase	Homo sapiens	40-45
23354604-8	2013	With the tempol pre-treatment, the immunoreactivity of COX-2 and nitrotyrosine in paraffin-embedded tissue slices was profoundly decreased.	tempol	9-15	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	55-60
23855710-0	2013	The carbonylation and covalent dimerization of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity is inhibited by the radical scavenger tempol.	tempol	170-176	superoxide dismutase 1	Homo sapiens	53-75
23855710-6	2013	The results showed that tempol (5-75 muM) does not inhibit hSOD1 turnover, but decreases its resulting oxidation to carbonylated and covalently dimerized forms.	tempol	24-30	latexin	Homo sapiens	37-40
23855710-8	2013	As a result, tempol was consumed nearly stoichiometrically with hSOD1 monomers.	tempol	13-19	superoxide dismutase 1	Homo sapiens	64-69
23855710-10	2013	Tempol consumption by the bicarbonate-dependent peroxidase activity of hSOD1 may be one of the reasons why high doses of tempol were required to afford protection in an ALS rat model.	tempol	0-6	superoxide dismutase 1	Homo sapiens	71-76
23855710-10	2013	Tempol consumption by the bicarbonate-dependent peroxidase activity of hSOD1 may be one of the reasons why high doses of tempol were required to afford protection in an ALS rat model.	tempol	121-127	superoxide dismutase 1	Homo sapiens	71-76
24042086-8	2013	The superoxide scavenger TEMPOL was also effective in preventing the effects of leptin on endothelial dysfunction.	tempol	25-31	leptin	Mus musculus	80-86
23747723-6	2013	BMP4-induced decrease of Kv4.3 K(+) channel protein expression was also reversed by the NADPH oxidase inhibitor apocynin and the radical scavenger tempol.	tempol	147-153	bone morphogenetic protein 4	Homo sapiens	0-4
23747723-6	2013	BMP4-induced decrease of Kv4.3 K(+) channel protein expression was also reversed by the NADPH oxidase inhibitor apocynin and the radical scavenger tempol.	tempol	147-153	potassium voltage-gated channel subfamily D member 3	Homo sapiens	25-30
23542920-0	2013	Tempol prevents cardiac oxidative damage and left ventricular dysfunction in the PPAR-alpha KO mouse.	tempol	0-6	peroxisome proliferator activated receptor alpha	Mus musculus	81-91
23542920-8	2013	Tempol also significantly increased glutathione peroxidase and glutathione reductase activities (~ 50%) in PPAR-alpha KO mice.	tempol	0-6	glutathione reductase	Mus musculus	63-84
23542920-8	2013	Tempol also significantly increased glutathione peroxidase and glutathione reductase activities (~ 50%) in PPAR-alpha KO mice.	tempol	0-6	peroxisome proliferator activated receptor alpha	Mus musculus	107-117
21917342-0	2013	Tempol inhibits TGF-beta and MMPs upregulation and prevents cardiac hypertensive changes.	tempol	0-6	transforming growth factor, beta 1	Rattus norvegicus	16-24
22251079-9	2013	Lung inflammation and serum TNF-alpha levels were significantly attenuated by both tadalafil and tempol.	tempol	97-103	tumor necrosis factor	Rattus norvegicus	28-37
24029484-6	2013	The mean relative optical density of MBP in the white matter was significantly higher in Tempol (8 mg/kg) group (0.82 +- 0.17) and Tempol (30 mg/kg) group (0.91 +- 0.15) than saline-treated group (0.44 +- 0.13, all P &lt; 0.01).	tempol	89-95	myelin basic protein	Rattus norvegicus	37-40
24029484-6	2013	The mean relative optical density of MBP in the white matter was significantly higher in Tempol (8 mg/kg) group (0.82 +- 0.17) and Tempol (30 mg/kg) group (0.91 +- 0.15) than saline-treated group (0.44 +- 0.13, all P &lt; 0.01).	tempol	131-137	myelin basic protein	Rattus norvegicus	37-40
21917342-0	2013	Tempol inhibits TGF-beta and MMPs upregulation and prevents cardiac hypertensive changes.	tempol	0-6	matrix metallopeptidase 2	Rattus norvegicus	29-33
21917342-14	2013	Tempol treatment decreased oxidative stress, TGF-beta levels, and gelatinolytic activity in 2K1C rats to control levels.	tempol	0-6	transforming growth factor, beta 1	Rattus norvegicus	45-53
23172369-7	2012	In addition, Tempol treatment increases the apoptotic rates of MDA-MB-231 cells, which have wild-type BRCA1, but share a basal-like breast cancer phenotype with HCC1937 cells.	tempol	13-19	BRCA1 DNA repair associated	Homo sapiens	102-107
23261940-7	2013	Plasma from PE induced KCa3.1 down regulation, NOX2 upregulation, phosphorylated-p38 mitogen-activated protein kinase downregulation, and superoxide generation, and these effects were prevented by antioxidants (tempol or tiron), NOX2 inhibition, or anti-lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1) antibody.	tempol	211-217	cytochrome b-245 beta chain	Homo sapiens	229-233
23261940-7	2013	Plasma from PE induced KCa3.1 down regulation, NOX2 upregulation, phosphorylated-p38 mitogen-activated protein kinase downregulation, and superoxide generation, and these effects were prevented by antioxidants (tempol or tiron), NOX2 inhibition, or anti-lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1) antibody.	tempol	211-217	oxidized low density lipoprotein receptor 1	Homo sapiens	317-321
22746319-7	2013	Intracisternal infusion of tempol or microinjection into the bilateral RVLM of adenovirus encoding superoxide dismutase significantly antagonized the PTEN inactivation and blunted the enhanced PI3K/Akt signaling in SHR.	tempol	27-33	phosphatase and tensin homolog	Rattus norvegicus	150-154
22746319-7	2013	Intracisternal infusion of tempol or microinjection into the bilateral RVLM of adenovirus encoding superoxide dismutase significantly antagonized the PTEN inactivation and blunted the enhanced PI3K/Akt signaling in SHR.	tempol	27-33	AKT serine/threonine kinase 1	Rattus norvegicus	198-201
23443543-5	2013	Treatment of TRPM2+/+ mice with the free radical scavenger Tempol or the PARP1 inhibitor 3-aminobenzamide attenuated irradiation-induced activation of TRPM2 and induced significant recovery of salivary fluid secretion.	tempol	59-65	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	13-18
23443543-5	2013	Treatment of TRPM2+/+ mice with the free radical scavenger Tempol or the PARP1 inhibitor 3-aminobenzamide attenuated irradiation-induced activation of TRPM2 and induced significant recovery of salivary fluid secretion.	tempol	59-65	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	151-156
23443543-6	2013	Furthermore, TPL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) induced complete recovery of function in irradiated TRPM2-/- mice.	tempol	13-16	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	118-123
23443543-6	2013	Furthermore, TPL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) induced complete recovery of function in irradiated TRPM2-/- mice.	tempol	18-64	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	118-123
22982597-1	2012	Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) and other cyclic nitroxides have been shown to inhibit the chlorinating activity of myeloperoxidase (MPO) in vitro and in cells.	tempol	0-6	myeloperoxidase	Rattus norvegicus	140-155
22982597-1	2012	Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) and other cyclic nitroxides have been shown to inhibit the chlorinating activity of myeloperoxidase (MPO) in vitro and in cells.	tempol	0-6	myeloperoxidase	Rattus norvegicus	157-160
22982597-1	2012	Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) and other cyclic nitroxides have been shown to inhibit the chlorinating activity of myeloperoxidase (MPO) in vitro and in cells.	tempol	8-54	myeloperoxidase	Rattus norvegicus	140-155
22982597-1	2012	Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) and other cyclic nitroxides have been shown to inhibit the chlorinating activity of myeloperoxidase (MPO) in vitro and in cells.	tempol	8-54	myeloperoxidase	Rattus norvegicus	157-160
22411927-3	2012	Here we studied the mechanisms of age-associated increase in oxidative stress on diminished D1R and exaggerated AT(1)R functions in the renal proximal tubules of control and antioxidant Tempol-treated adult and old FBN rats.	tempol	186-192	angiotensin II receptor, type 1a	Rattus norvegicus	112-118
23006058-10	2012	In LPK rats, tempol treatment reduced immunofluorescence for 3-nitrotyrosine and HIF1A mRNA while upregulating VEGF and p47phox mRNA expression, but otherwise had little impact on disease progression, renal tissue hypoxia or hypertension.	tempol	13-19	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	81-86
23006058-10	2012	In LPK rats, tempol treatment reduced immunofluorescence for 3-nitrotyrosine and HIF1A mRNA while upregulating VEGF and p47phox mRNA expression, but otherwise had little impact on disease progression, renal tissue hypoxia or hypertension.	tempol	13-19	vascular endothelial growth factor A	Rattus norvegicus	111-115
23006058-10	2012	In LPK rats, tempol treatment reduced immunofluorescence for 3-nitrotyrosine and HIF1A mRNA while upregulating VEGF and p47phox mRNA expression, but otherwise had little impact on disease progression, renal tissue hypoxia or hypertension.	tempol	13-19	neutrophil cytosolic factor 1	Rattus norvegicus	120-127
23178531-10	2012	Taken together our data identify Tempol as an agent with potential therapeutic activity targeting expression of HIF2alpha in VHL-deficient clear cell kidney cancer and illustrate the importance of studying biochemical processes at relevant physiological O2 levels.	tempol	33-39	endothelial PAS domain protein 1	Homo sapiens	112-121
22718806-12	2012	Administration of tempol attenuated the hypertension (101 +- 3 mmHg) ROS (459 +- 5 RLU ml(-1) min(-1)) and blunted AT1-AAs (7.3 +- 0.6 beats/min) in NP+IL-17+tempol-treated rats.	tempol	18-24	angiotensin II receptor, type 1a	Rattus norvegicus	115-118
22718806-12	2012	Administration of tempol attenuated the hypertension (101 +- 3 mmHg) ROS (459 +- 5 RLU ml(-1) min(-1)) and blunted AT1-AAs (7.3 +- 0.6 beats/min) in NP+IL-17+tempol-treated rats.	tempol	18-24	interleukin 17A	Rattus norvegicus	152-157
22958438-13	2012	Finally, the LPS-promoted long-term pressor response and the reduction in expression of voltage-gated potassium channel, Kv4.3 in RVLM were antagonized by minocycline, NS398, pentoxifylline, or a superoxide dismutase mimetic, tempol, either infused into cisterna magna or microinjected bilaterally into RVLM.	tempol	226-232	potassium voltage-gated channel subfamily D member 3	Rattus norvegicus	121-126
22423051-3	2012	The hypothesis that the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve uterine artery function and rescue fetal growth was tested in a mouse model of FGR, using the endothelial nitric oxide synthase knockout mouse (Nos3(-/-)).	tempol	36-81	nitric oxide synthase 3, endothelial cell	Mus musculus	199-232
22423051-3	2012	The hypothesis that the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve uterine artery function and rescue fetal growth was tested in a mouse model of FGR, using the endothelial nitric oxide synthase knockout mouse (Nos3(-/-)).	tempol	36-81	nitric oxide synthase 3, endothelial cell	Mus musculus	249-253
22423051-3	2012	The hypothesis that the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve uterine artery function and rescue fetal growth was tested in a mouse model of FGR, using the endothelial nitric oxide synthase knockout mouse (Nos3(-/-)).	tempol	83-89	nitric oxide synthase 3, endothelial cell	Mus musculus	199-232
22423051-3	2012	The hypothesis that the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve uterine artery function and rescue fetal growth was tested in a mouse model of FGR, using the endothelial nitric oxide synthase knockout mouse (Nos3(-/-)).	tempol	83-89	nitric oxide synthase 3, endothelial cell	Mus musculus	249-253
22405822-4	2012	Pretreatment of the cells with either candesartan (a selective Ang II type 1 receptor [AT(1)R] antagonist) or Tempol (a cell-permeable superoxide scavenger) significantly inhibited Ang II-induced DNA synthesis.	tempol	110-116	angiotensin II, type I receptor-associated protein	Mus musculus	87-93
22405822-4	2012	Pretreatment of the cells with either candesartan (a selective Ang II type 1 receptor [AT(1)R] antagonist) or Tempol (a cell-permeable superoxide scavenger) significantly inhibited Ang II-induced DNA synthesis.	tempol	110-116	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	181-187
22024718-6	2012	MEK and JNK inhibitors significantly attenuated a growth inhibition in Tempol-treated             As4.1 cells.	tempol	71-77	midkine	Mus musculus	0-3
22129514-6	2012	These residual effects after Ang II infusion were all attenuated by the co-administration of tempol, a free radical scavenger, or candesartan with Ang II.	tempol	93-99	angiotensinogen	Rattus norvegicus	29-35
22024718-6	2012	MEK and JNK inhibitors significantly attenuated a growth inhibition in Tempol-treated             As4.1 cells.	tempol	71-77	mitogen-activated protein kinase 8	Mus musculus	8-11
22139554-7	2012	In accordance, N-acetyl-cysteine and tempol, but not apocynin, inhibited the hypoxic effect and restored PKCepsilon protein and mRNA expression to the control values in foetal hearts and H9c2 cells.	tempol	37-43	protein kinase C, epsilon	Rattus norvegicus	105-115
22081706-9	2012	Tempol attenuated both [(14)C]sucrose and [(3)H]codeine brain uptake as well as protected occludin oligomers from disruption in CIP animals, suggesting that ROS production/oxidative stress is involved in modulating BBB functional integrity during pain/inflammation.	tempol	0-6	occludin	Rattus norvegicus	90-98
21564089-8	2012	Only a combination of argatroban with vitamin C or tempol prevented both the enhancement and prolongation of the contractile response to PAR1-AP and restored the reversibility of the thrombin-induced contraction.	tempol	51-57	prothrombin	Oryctolagus cuniculus	183-191
22179086-6	2012	Interleukin-1beta-induced COX-2 expression was reduced by apocynin, tempol (10 mumol/l), catalase (1000 U/ml) and lactacystin (5 mumol/l).	tempol	68-74	interleukin 1 beta	Rattus norvegicus	0-17
22179086-6	2012	Interleukin-1beta-induced COX-2 expression was reduced by apocynin, tempol (10 mumol/l), catalase (1000 U/ml) and lactacystin (5 mumol/l).	tempol	68-74	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	26-31
21803946-4	2011	Preincubation with the antioxidant tempol or the nitric oxide (NO) donor diethylenetriamine NONOate and acute and chronic administration of the AT(2) receptor agonist CGP-42112 mimicked the protective effect of ANG-(1-7) to restore vascular relaxation.	tempol	35-41	angiopoietin 1	Homo sapiens	211-219
22508061-9	2012	The effect of rapamycin on TNF-alpha release was also mimicked by the antioxidant ROS scavenger Tempol (30 muM) and partially reversed by additional application of tert-butylhydroperoxide (10 muM).	tempol	96-102	tumor necrosis factor	Mus musculus	27-36
22942680-5	2012	Consistently, ODN MT01 induced up-regulation of osteocalcin, alkaline phosphatase (ALP) and type I collagen, which was inhibited by pre-treatment with the ERK1/2 inhibitor U0126 and the p38 inhibitor SB203580.	tempol	18-22	bone gamma-carboxyglutamate protein	Homo sapiens	48-59
22942680-5	2012	Consistently, ODN MT01 induced up-regulation of osteocalcin, alkaline phosphatase (ALP) and type I collagen, which was inhibited by pre-treatment with the ERK1/2 inhibitor U0126 and the p38 inhibitor SB203580.	tempol	18-22	alkaline phosphatase, placental	Homo sapiens	61-81
22942680-5	2012	Consistently, ODN MT01 induced up-regulation of osteocalcin, alkaline phosphatase (ALP) and type I collagen, which was inhibited by pre-treatment with the ERK1/2 inhibitor U0126 and the p38 inhibitor SB203580.	tempol	18-22	alkaline phosphatase, placental	Homo sapiens	83-86
22942680-5	2012	Consistently, ODN MT01 induced up-regulation of osteocalcin, alkaline phosphatase (ALP) and type I collagen, which was inhibited by pre-treatment with the ERK1/2 inhibitor U0126 and the p38 inhibitor SB203580.	tempol	18-22	mitogen-activated protein kinase 3	Homo sapiens	155-161
22942680-5	2012	Consistently, ODN MT01 induced up-regulation of osteocalcin, alkaline phosphatase (ALP) and type I collagen, which was inhibited by pre-treatment with the ERK1/2 inhibitor U0126 and the p38 inhibitor SB203580.	tempol	18-22	mitogen-activated protein kinase 1	Homo sapiens	186-189
22673147-12	2012	These results suggest that chronic treatment of diabetic rats with tempol can protect kidneys, possibly by reducing expression of TGF-beta1, Col IV, and upregulating TRPC6 expression level.	tempol	67-73	transforming growth factor, beta 1	Rattus norvegicus	130-139
22673147-12	2012	These results suggest that chronic treatment of diabetic rats with tempol can protect kidneys, possibly by reducing expression of TGF-beta1, Col IV, and upregulating TRPC6 expression level.	tempol	67-73	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	166-171
22911865-5	2012	Tempol treatment (0.5 mmol/L) during high-salt feeding abolished the changes in DHE fluorescence, p22phox and SGK1.	tempol	0-6	cytochrome b-245 alpha chain	Rattus norvegicus	98-105
22911865-5	2012	Tempol treatment (0.5 mmol/L) during high-salt feeding abolished the changes in DHE fluorescence, p22phox and SGK1.	tempol	0-6	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	110-114
21940665-8	2011	Losartan (1 muM), apocynin (100 muM), and tempol (1 mM) normalized the enhanced HCN current density and increased the cell excitability in the aortic baroreceptor neurons of diabetic rats.	tempol	42-48	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	80-83
21749327-5	2011	However, we noticed that tempol inhibits the chlorinating activity of MPO, in contrast with tyrosine.	tempol	25-31	myeloperoxidase	Homo sapiens	70-73
21749327-6	2011	Thus we studied the inhibition of MPO-mediated taurine chlorination by tempol at pH 7.4 and re-determined the kinetic constants of the reactions of tempol with MPO-I (k=3.5x105 M-1 s-1) and MPO-II, the kinetics of which indicated a binding interaction (K=2.0x10-5 M; k=3.6x10-2 s-1).	tempol	71-77	myeloperoxidase	Homo sapiens	34-37
21749327-9	2011	After turnover, a minor fraction of MPO is irreversibly inactivated, probably due to its reaction with the oxammonium cation resulting from tempol oxidation.	tempol	140-146	myeloperoxidase	Homo sapiens	36-39
22172488-5	2012	Treatment with Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), a SOD mimetic, not only lowered cellular superoxide levels but also concomitantly attenuated AR transcriptional activity and AR target gene expression in a dose- and time-dependent manner, in the presence and absence of dihydrotestosterone, the major endogenous AR agonist.	tempol	15-21	superoxide dismutase 2	Homo sapiens	74-77
22172488-5	2012	Treatment with Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), a SOD mimetic, not only lowered cellular superoxide levels but also concomitantly attenuated AR transcriptional activity and AR target gene expression in a dose- and time-dependent manner, in the presence and absence of dihydrotestosterone, the major endogenous AR agonist.	tempol	15-21	androgen receptor	Homo sapiens	165-167
22172488-5	2012	Treatment with Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), a SOD mimetic, not only lowered cellular superoxide levels but also concomitantly attenuated AR transcriptional activity and AR target gene expression in a dose- and time-dependent manner, in the presence and absence of dihydrotestosterone, the major endogenous AR agonist.	tempol	15-21	androgen receptor	Homo sapiens	197-199
22172488-5	2012	Treatment with Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), a SOD mimetic, not only lowered cellular superoxide levels but also concomitantly attenuated AR transcriptional activity and AR target gene expression in a dose- and time-dependent manner, in the presence and absence of dihydrotestosterone, the major endogenous AR agonist.	tempol	15-21	androgen receptor	Homo sapiens	197-199
22172488-5	2012	Treatment with Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), a SOD mimetic, not only lowered cellular superoxide levels but also concomitantly attenuated AR transcriptional activity and AR target gene expression in a dose- and time-dependent manner, in the presence and absence of dihydrotestosterone, the major endogenous AR agonist.	tempol	23-69	superoxide dismutase 2	Homo sapiens	74-77
22172488-5	2012	Treatment with Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), a SOD mimetic, not only lowered cellular superoxide levels but also concomitantly attenuated AR transcriptional activity and AR target gene expression in a dose- and time-dependent manner, in the presence and absence of dihydrotestosterone, the major endogenous AR agonist.	tempol	23-69	androgen receptor	Homo sapiens	165-167
22172488-5	2012	Treatment with Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), a SOD mimetic, not only lowered cellular superoxide levels but also concomitantly attenuated AR transcriptional activity and AR target gene expression in a dose- and time-dependent manner, in the presence and absence of dihydrotestosterone, the major endogenous AR agonist.	tempol	23-69	androgen receptor	Homo sapiens	197-199
22172488-5	2012	Treatment with Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), a SOD mimetic, not only lowered cellular superoxide levels but also concomitantly attenuated AR transcriptional activity and AR target gene expression in a dose- and time-dependent manner, in the presence and absence of dihydrotestosterone, the major endogenous AR agonist.	tempol	23-69	androgen receptor	Homo sapiens	197-199
22172488-8	2012	Importantly, effects of Tempol on AR function were accompanied by significant in vitro and in vivo reduction in castration-resistant prostate cancer (CRPC) survival and growth.	tempol	24-30	androgen receptor	Homo sapiens	34-36
22815806-9	2012	Bilateral PVN pretreatment with either superoxide anion scavenger tempol or polyethylene glycol-superoxide dismutase (PEG-SOD) inhibited the effects of ET-1 on the CSAR, RSNA and MAP.	tempol	66-72	endothelin 1	Rattus norvegicus	152-156
22015457-8	2011	Chronic administration of tempol, a superoxide scavenger, reduced intraretinal oxidized LDL and glycated LDL levels, PGIS nitration, and retina cell apoptosis, thereby preserving the integrity of blood-retinal barriers.	tempol	26-32	prostaglandin I2 synthase	Homo sapiens	117-121
21906672-5	2011	Systemic administration of Tempol, a membrane-permeative superoxide dismutase mimetic, reduced arterial pressure as well as urinary excretion of oxidative stress markers and reduced both angiotensin II and norepinephrine plasma levels in KAP Tg mice.	tempol	27-33	kidney androgen regulated protein	Mus musculus	238-241
21843894-10	2011	In arteries treated with the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (tempol), flow-mediated dilation and myogenic tone were similar in nonpulsatile and pulsatile arteries; monocyte chemotactic protein 1 and nuclear factor kappaB expression levels were not increased in tempol-treated nonpulsatile arteries.	tempol	41-86	C-C motif chemokine ligand 2	Rattus norvegicus	191-221
21593187-10	2011	A high concentration of ANG II (1 muM) inhibited NHE3 activity in control and tempol-treated rats.	tempol	78-84	angiotensinogen	Rattus norvegicus	24-30
20712414-6	2011	However, in both the p47 phox ko mice and the tempol-treated mice, low magnitude oscillatory WSS produced an increase in VCAM-1 expression comparable to control mice.	tempol	46-52	vascular cell adhesion molecule 1	Mus musculus	121-127
21859962-4	2011	Stretch-induced fluorescence was reduced significantly (P&lt;0.05) by incubation with Tempol (3.7+-0.8%), pegylated superoxide dismutase (3.2+-1.0%), or apocynin (3.5+-0.9%) but not by pegylated catalase, L-nitroarginine methylester, or Ca(2+)-free medium, relating it to Ca(2+)-independent vascular superoxide.	tempol	86-92	catalase	Mus musculus	195-203
21859962-7	2011	Tempol had no further effect after superoxide dismutase but remained effective after catalase.	tempol	0-6	catalase	Mus musculus	85-93
21525431-6	2011	The antioxidant effect observed in cultured cells was also observed in diabetic rats treated with tempol for 2 wk, which exhibited a preservation of TRPC6 in the glomeruli.	tempol	98-104	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	149-154
21593187-10	2011	A high concentration of ANG II (1 muM) inhibited NHE3 activity in control and tempol-treated rats.	tempol	78-84	solute carrier family 9 member A3	Rattus norvegicus	49-53
21371005-7	2011	Tempol, a reactive oxygen species (ROS) scavenger, improved endothelium-dependent vasorelaxation in kidneys of saline-treated apoE (-/-) mice whereas no effect was observed in Ang-(1-7)-treated mice.	tempol	0-6	apolipoprotein E	Mus musculus	126-130
21554869-3	2011	In this study, we determine the effects of tempol, a membrane-permeable radical scavenger, in lipopolysaccharide (LPS)-induced acute lung injury and the underlying mechanism.	tempol	43-49	toll-like receptor 4	Mus musculus	114-117
21554869-8	2011	Pretreatment with tempol produced significant attenuation of LPS-induced lung injury as well as inhibition of LPS mediated increase in MPO immunostaining, MDA and NO levels in lung tissue.	tempol	18-24	toll-like receptor 4	Mus musculus	61-64
21554869-8	2011	Pretreatment with tempol produced significant attenuation of LPS-induced lung injury as well as inhibition of LPS mediated increase in MPO immunostaining, MDA and NO levels in lung tissue.	tempol	18-24	myeloperoxidase	Mus musculus	135-138
21562428-12	2011	Tempol also reduced hypoxia-induced SMC proliferation and elastin deposition in the PA.	tempol	0-6	elastin	Rattus norvegicus	58-65
21720272-8	2011	Irbesartan and tempol, independently of blood pressure, markedly prevented salt-induced glomerular injury in eNOS-/- mice, and these protective effects were attributed to the attenuation of glomerular oxidative stress and glomerular angiotensinogen-derived angiotensin II.	tempol	15-21	nitric oxide synthase 3, endothelial cell	Mus musculus	109-113
21472019-9	2011	MAP in AT1-AA + tempol rats was 109 +- 2 mm Hg, no difference than tempol-treated controls (109 +- 3 mm Hg).	tempol	16-22	angiotensin II receptor, type 1a	Rattus norvegicus	7-10
21460197-6	2011	Inhibition of MMP activation (with GM-6001) or ROS production (with apocynin or tempol) prevented the NE + ANG II-induced inward remodeling.	tempol	80-86	angiotensinogen	Rattus norvegicus	107-113
21030671-6	2011	Sin-1 exposure caused a disproportionately large decrease in Ca(2+) sensitivity, evidently due to coproduction of superoxide, as it was prevented by Tempol, a superoxide dismutase mimetic.	tempol	149-155	MAPK associated protein 1	Homo sapiens	0-5
21270817-7	2011	Pretreatment with CV11974 (100 nM) or tempol (3 mM) abolished Ang II-induced astrocyte beta-galactosidase staining.	tempol	38-44	angiotensinogen	Homo sapiens	62-68
21270817-7	2011	Pretreatment with CV11974 (100 nM) or tempol (3 mM) abolished Ang II-induced astrocyte beta-galactosidase staining.	tempol	38-44	galactosidase beta 1	Homo sapiens	87-105
21239635-2	2011	Treatment of diabetic rats with nitro-L-arginine methyl ester (L-NAME) to inhibit nitric oxide synthase or with tempol to reduce superoxide prevented these changes, suggesting the possibility that peroxynitrite (ONOO) may be the stimulus for the induction of renal COX-2 in diabetes.	tempol	112-118	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	265-270
21036124-8	2011	Pretreatment with tempol (a SOD mimetic, 50mg/kg) or co-enzyme Q(10) (50mg/kg) not only decreased the superoxide production, but also reduced the infarct size and normalized mitochondrial dysfunction in the gastrocnemius muscle.	tempol	18-24	superoxide dismutase 2, mitochondrial	Mus musculus	28-31
21210749-6	2011	The antioxidant agents tempol and diphenyleneiodonium (DPI) reverted the hyperreactivity to Ang II in HT rings.	tempol	23-29	angiotensinogen	Homo sapiens	92-98
21210749-13	2011	With regard to resting membrane potential, we found in HT rings that the depolarization induced by Ang II was abolished by tempol.	tempol	123-129	angiotensinogen	Homo sapiens	99-105
21935366-7	2011	Tempol, an antioxidant compound, was used to investigate the impact of ROS on cycling hypoxia-mediated HIF-1 activation and tumor progression.	tempol	0-6	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-108
21935366-10	2011	Moreover, in vivo molecular imaging studies demonstrated that Tempol is a good antioxidant compound for inhibiting cycling hypoxia-mediated ROS production, HIF-1 activation, and tumor growth.	tempol	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-161
20870012-10	2010	Tempol was given via drinking water (2 mmol) on day 4th following Ang II infusion, since oxidative stress increases in this model on day 4.	tempol	0-6	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	66-72
20954712-10	2010	Furthermore, both antioxidant (N-acetyl cysteine and tempol) and the VEGF antibody treatments significantly lowered the arsenite-induced permeability of the bEnd3 monolayer as well as VEGF expression.	tempol	53-59	BEN domain containing 3	Mus musculus	157-162
20884002-1	2010	The structure of the octadecyl (C18) chain layer attached to a silica surface in the presence of binary solvents (acetonitrile/water; methanol/water) was investigated by electron paramagnetic resonance (EPR) and reverse-phase high-performance liquid chromatography (RP-HPLC), using 4-hydroxy-2,2,6,6 tetramethylpiperidine-N-oxyl (Tempol) to mimic the behavior of pollutants with medium-low polarity.	tempol	282-328	Bardet-Biedl syndrome 9	Homo sapiens	32-35
20884002-1	2010	The structure of the octadecyl (C18) chain layer attached to a silica surface in the presence of binary solvents (acetonitrile/water; methanol/water) was investigated by electron paramagnetic resonance (EPR) and reverse-phase high-performance liquid chromatography (RP-HPLC), using 4-hydroxy-2,2,6,6 tetramethylpiperidine-N-oxyl (Tempol) to mimic the behavior of pollutants with medium-low polarity.	tempol	330-336	Bardet-Biedl syndrome 9	Homo sapiens	32-35
20954712-10	2010	Furthermore, both antioxidant (N-acetyl cysteine and tempol) and the VEGF antibody treatments significantly lowered the arsenite-induced permeability of the bEnd3 monolayer as well as VEGF expression.	tempol	53-59	vascular endothelial growth factor A	Mus musculus	184-188
20561604-6	2010	Mice on a Tempol diet demonstrated reduced systemic levels of IGF-1, in qualitative agreement with in vitro observations in 3T3-L1 cells, which also showed lower IGF-1 levels as a result of Tempol treatment.	tempol	10-16	insulin-like growth factor 1	Mus musculus	62-67
20807791-3	2010	In cultured adventitial fibroblasts, TGF-beta1 induced increases in superoxide and collagen I protein (P &lt; 0.05), which were inhibited by Tempol, a superoxide dismutase.	tempol	141-147	transforming growth factor, beta 1	Mus musculus	37-46
20814019-6	2010	The Ang II-induced BDNF upregulation in RVLM was attenuated by coadministration of the NADPH oxidase inhibitor apocynin; the superoxide dismutase mimetic tempol; or an antisense oligonucleotide against CREB.	tempol	154-160	angiotensinogen	Homo sapiens	4-10
20814019-6	2010	The Ang II-induced BDNF upregulation in RVLM was attenuated by coadministration of the NADPH oxidase inhibitor apocynin; the superoxide dismutase mimetic tempol; or an antisense oligonucleotide against CREB.	tempol	154-160	brain derived neurotrophic factor	Homo sapiens	19-23
20561604-6	2010	Mice on a Tempol diet demonstrated reduced systemic levels of IGF-1, in qualitative agreement with in vitro observations in 3T3-L1 cells, which also showed lower IGF-1 levels as a result of Tempol treatment.	tempol	10-16	insulin-like growth factor 1	Mus musculus	162-167
20194307-6	2010	In histological analysis, Ang II-induced atrial interstitial fibrosis, perivascular fibrosis, and cardiomyocyte hypertrophy were all attenuated by pitavastatin and Tempol.	tempol	164-170	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	26-32
20504883-10	2010	This supposition is supported by increases seen in p65-NF-kappaB, osteopontin, and leukocyte influx in the kidneys of the tempol-treated group.	tempol	122-128	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	51-64
20504883-10	2010	This supposition is supported by increases seen in p65-NF-kappaB, osteopontin, and leukocyte influx in the kidneys of the tempol-treated group.	tempol	122-128	secreted phosphoprotein 1	Mus musculus	66-77
20335612-10	2010	CONCLUSIONS: The administration of tempol prevented oxidative damage, decreased iNOS levels, and ameliorated the activation of PARP in the retinas of diabetic hypertensive rats.	tempol	35-41	nitric oxide synthase 2	Rattus norvegicus	80-84
20651824-3	2010	The HG-induced impairment of endothelium-dependent relaxation was prevented by cotreatment with tempol (a SOD mimetic).	tempol	96-102	superoxide dismutase 2, mitochondrial	Mus musculus	106-109
20357031-9	2010	However, treatment of animals with tempol abolished the effect of LK intake on MAPK and c-Src and increased ROMK channel activity in comparing with those of nontreated rats on a LK diet.	tempol	35-41	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	88-93
20299472-8	2010	Finally, Tempol administration markedly attenuated impaired endothelium-dependent vasorelaxation, SERCA oxidation, ER stress, and atherosclerosis in ApoE(-/-) and ApoE(-/-)/AMPKalpha2(-/-) fed a high-fat diet.	tempol	9-15	apolipoprotein E	Mus musculus	149-153
20299472-8	2010	Finally, Tempol administration markedly attenuated impaired endothelium-dependent vasorelaxation, SERCA oxidation, ER stress, and atherosclerosis in ApoE(-/-) and ApoE(-/-)/AMPKalpha2(-/-) fed a high-fat diet.	tempol	9-15	apolipoprotein E	Mus musculus	163-167
20299472-8	2010	Finally, Tempol administration markedly attenuated impaired endothelium-dependent vasorelaxation, SERCA oxidation, ER stress, and atherosclerosis in ApoE(-/-) and ApoE(-/-)/AMPKalpha2(-/-) fed a high-fat diet.	tempol	9-15	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	173-183
20164374-8	2010	Interestingly, the treatment of diabetic rats with desferoxamine or tempol (antioxidants/hydroxyl radical scavengers) significantly attenuated the increase in both hydroxyl radical production and in LPO produced by hyperglycemia, preventing apoptosis by reduction of mitochondrial BAX and cytosolic cytochrome c levels.	tempol	68-74	BCL2 associated X, apoptosis regulator	Rattus norvegicus	281-284
19846752-9	2010	In addition, NADPH oxidase inhibitor (100 muM apocynin) and superoxide scavenger (1 mM tempol) also significantly blunted the ANG II-induced increase of the I(h) and decrease of the membrane excitability in the AB neurons.	tempol	87-93	angiotensinogen	Rattus norvegicus	126-132
20007914-7	2010	In LS heart tissues, lucigenin chemiluminescence was increased 2.3-fold to angiotensin II (10(-8) mol/L), and bradykinin (10(-4) mol/L) induced reduction of myocardial oxygen consumption in vitro was decreased (40 + or - 1.3% to 16 + or - 6.3%) and completely restored by coincubation with tiron, tempol or apocynin.	tempol	297-303	kininogen 1	Homo sapiens	110-120
20124121-12	2010	Furthermore, Tempol, which restored SERCA activity and decreased oxidized SERCA levels, markedly reduced the level of ER stress in mouse aortic endothelial cells from AMPKalpha2(-/-) mice.	tempol	13-19	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	167-177
19846752-10	2010	Furthermore, losartan, apocynin, or tempol significantly attenuated the superoxide overproduction in the NG tissues induced by ANG II.	tempol	36-42	angiotensinogen	Rattus norvegicus	127-133
19645750-6	2009	Bilateral PVN microinjection of Ang II (0.3 nmol) enhanced the CSAR and increased RSNA and MAP, which was inhibited by the pre-treatment with RVLM administration of tempol, PEG-SOD, apocynin or PAO.	tempol	165-171	angiotensinogen	Rattus norvegicus	32-38
20703012-6	2010	Pretreatment with tempol or L-NAME was effective in protecting the noise-exposed animals from hearing loss, as well as in abolishing the noise-induced activation of the JNK signaling pathway.	tempol	18-24	mitogen-activated protein kinase 8	Mus musculus	169-172
19376805-8	2009	Tempol (1 mM), a scavenger of superoxide, improved relaxation in response to acetylcholine (63 +/- 8%) in old ecSOD(-/-) mice (P &lt; 0.05), but not wild-type mice (75 +/- 4%).	tempol	0-6	superoxide dismutase 3, extracellular	Mus musculus	110-115
19513907-4	2009	Tempol significantly antagonized the respiratory effects of SIN-1 in parallel with an attenuation of 3-NT levels.	tempol	0-6	MAPK associated protein 1	Homo sapiens	60-65
18987049-5	2009	These parameters were suppressed by tempol and oxypurinal (a xanthine oxidase inhibitor).	tempol	36-42	xanthine dehydrogenase	Mus musculus	61-77
19132383-8	2009	The normalization of the CSAR, levels of superoxide anions and AT(1) receptor expression, and the response to angiotensin II in the paraventricular nucleus and rostral ventrolateral medulla may partially contribute to the beneficial effects of tempol on central sympathetic control.	tempol	244-250	angiotensinogen	Rattus norvegicus	110-124
19248829-11	2009	Tempol was more effective than apocyanin in attenuating hypertension-induced increases in oxidative stress (both p&lt;0.05), MMP-2 levels, and MMP-2 activity in hypertensive rats (all p&lt;0.05).	tempol	0-6	matrix metallopeptidase 2	Rattus norvegicus	125-130
19248829-11	2009	Tempol was more effective than apocyanin in attenuating hypertension-induced increases in oxidative stress (both p&lt;0.05), MMP-2 levels, and MMP-2 activity in hypertensive rats (all p&lt;0.05).	tempol	0-6	matrix metallopeptidase 2	Rattus norvegicus	143-148
19151253-9	2009	ARB or tempol improved insulin-mediated EDR, PI3K, Akt/ endothelial NO synthase phosphorylation, and metabolic IR (all P &lt; 0.05).	tempol	7-13	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
19041937-8	2009	Total LV ROS production was significantly higher in TNF animals than in controls; APO or Temp treatment ameliorated TNF-induced LV ROS production.	tempol	89-93	tumor necrosis factor	Rattus norvegicus	116-119
19366904-9	2009	Use of 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (a superoxide dismutase mimetic) prevented both vasoconstriction with iodixanol alone and increased constriction with angiotensin II caused by CM.	tempol	7-53	angiotensinogen	Homo sapiens	172-186
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	tempol	68-74	mitogen-activated protein kinase 12	Homo sapiens	136-142
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	tempol	68-74	mitogen-activated protein kinase 12	Homo sapiens	144-152
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	tempol	68-74	mitogen-activated protein kinase 13	Homo sapiens	155-162
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	tempol	68-74	mitogen-activated protein kinase 13	Homo sapiens	164-172
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	tempol	68-74	heat shock protein family B (small) member 1	Homo sapiens	179-184
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	tempol	68-74	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	246-253
19286753-6	2009	RESULTS: ICV administration of Ang II to conscious hydrated rats resulted in a significant decrease in urinary volume in the first hour, and an increased sodium and potassium excretion during the 6-hour period of urine collection, which was most effective during the 3 and 6 h. Interference with the NAD(P)H oxidase signalling by central administration of apocynin, tempol or chelerythrine, blunted the natriuretic and kaliuretic effect induced by central administration of Ang II, without affecting its antidiuretic action.	tempol	366-372	angiotensinogen	Rattus norvegicus	31-37
19056377-7	2009	Increased dihydroethidium (DHE) fluorescence in response to TGF-beta1, which was inhibited by DETA-NONOate and TEMPOL, suggested a role for intracellular superoxide in TGF-beta1 signalling.	tempol	111-117	transforming growth factor beta 1	Homo sapiens	60-69
19087872-4	2009	Therefore, the aim of the current study was to investigate the modulatory effect of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl [TEMPOL (50 mg/kg)], a SOD mimetic, and the SOD inhibitor, diethyldithiocarbamate [DETCA (100 mg/kg)] on gastric lesions induced by ischemia/reperfusion.	tempol	132-138	superoxide dismutase 1	Homo sapiens	154-157
19075094-11	2009	Surprisingly, treatment with 100 micromol/L of Tempol, a superoxide dismutase mimetic, blocked the angiotensin II-induced decrease in NOS3 expression (Delta=-3+/-7%; n=6).	tempol	47-53	angiotensinogen	Rattus norvegicus	99-113
19075094-11	2009	Surprisingly, treatment with 100 micromol/L of Tempol, a superoxide dismutase mimetic, blocked the angiotensin II-induced decrease in NOS3 expression (Delta=-3+/-7%; n=6).	tempol	47-53	nitric oxide synthase 3	Rattus norvegicus	134-138
19556798-11	2009	A marked reduction in PARP activity was found in the lung and kidney glomeruli of the CLP + tempol group (p(lung) = 0.0026, p(glomeruli) = 0.0085).	tempol	92-98	poly (ADP-ribose) polymerase family, member 1	Mus musculus	22-26
19023275-9	2009	Treatment with 17beta-estradiol (E(2)), tempol, or aminoguanidine for 6 weeks prevented Ovx-induced blood pressure elevation and apparently reversed the MMPs changes.	tempol	40-46	matrix metallopeptidase 2	Rattus norvegicus	153-157
18533188-10	2008	Tempol administration significantly reduced myeloperoxidase activity and malondialdehyde levels, and also significantly increased glutathione and NO(x) levels of both intestinal and lung tissues, biochemically (P &lt; 0.05).	tempol	0-6	myeloperoxidase	Rattus norvegicus	44-59
18922887-10	2008	However, TNF-alpha induced an increase in RBF and caused attenuation of the GFR reduction in mice pretreated with superoxide (O(2)(-)) scavenger tempol (2 microg.g(-1).min(-1); n = 6).	tempol	145-151	tumor necrosis factor	Mus musculus	9-18
19521108-11	2009	Spironolactone, apocynin, and tempol significantly reduced SGK1 expression.	tempol	30-36	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	59-63
18551023-9	2008	Both tempol and eplerenone inhibited the angiotensin-II/salt-induced upregulation of Na(+) -H(+) exchanger isoform 1.	tempol	5-11	angiotensinogen	Rattus norvegicus	41-55
18685102-5	2008	In this study, we fed IRP2(-/-) mice a diet supplemented with a stable nitroxide, Tempol, and showed that the progression of neuromuscular impairment was markedly attenuated.	tempol	82-88	iron responsive element binding protein 2	Mus musculus	22-26
18599599-5	2008	Either central infusion of Tempol or 17beta-estradiol (E2) attenuated the pressor effect of ANG II (Delta10.9 +/- 2.3 and Delta4.5 +/- 1.4 mmHg), and the protective effect of E2 was prevented by the coadministration of an estrogen receptor, antagonist ICI-182780 (Delta23.6 +/- 3.1 mmHg).	tempol	27-33	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	92-98
18614617-13	2008	Tempol, while reducing oxidative stress, normalizes AT1 receptor signaling and decreases blood pressure.	tempol	0-6	angiotensin II receptor, type 1a	Rattus norvegicus	52-55
18788099-7	2008	Tempol (a scavenger of superoxide), apocynin (an inhibitor of NADPH oxidase) and allopurinol (an inhibitor of xanthine oxidase) all not only decreased superoxide in carotid arteries, but also suppressed arterial contractions to U46619 in Ins2(Akita) diabetic mice.	tempol	0-6	insulin II	Mus musculus	238-242
18452717-8	2008	The CGN-induced decline in phospho-Hsp27 was reversed by co-administration of Tempol (100 nM), but unaffected by silencing Bcl10.	tempol	78-84	heat shock protein family B (small) member 1	Homo sapiens	35-40
18551023-6	2008	However, angiotensin-II/salt-induced cardiac dysfunction was restored by eplerenone and tempol.	tempol	88-94	angiotensinogen	Rattus norvegicus	9-23
17533199-6	2007	There was substantially diminished Akt and endothelial NO synthase activation in Ren2 aortas in response to in vivo insulin stimulation, and this was significantly improved by in vivo treatment with valsartan or tempol.	tempol	212-218	AKT serine/threonine kinase 1	Rattus norvegicus	35-38
18256310-9	2008	The cell-permeable superoxide dismutase mimetic tempol (5 mg.kg(-1).min(-1) ira), which reduces O(2)(-) and may elevate H(2)O(2), attenuated ET-1 responses similar to apocynin (by 38 +/- 6%, P &lt; 0.01).	tempol	48-54	endothelin 1	Homo sapiens	141-145
18250367-5	2008	Intrarenal Tempol (superoxide dismutase mimetic) or Y27632 (Rho kinase inhibitor) abolished the interaction between UK14,304 and angiotensin II both in vivo and in vitro.	tempol	11-17	angiotensinogen	Rattus norvegicus	129-143
18025227-6	2007	Prior administration of the free radical scavengers, tempol and N-acetyl-L-cysteine, abolished the stress induction of p38 activation and the resulting mucosal inflammation and gastric injury.	tempol	53-59	mitogen activated protein kinase 14	Rattus norvegicus	119-122
17644566-8	2007	To test physiological relevance in vivo, topical application of tempol caused a transient dilation (184 +/- 20%) of mouse cremaster arterioles exposed to angiotensin II for 30 min, which was not seen with NBT (9 +/- 4%).	tempol	64-70	angiotensinogen	Rattus norvegicus	154-168
17719272-4	2007	PVN pretreatment with tempol or tiron abolished, whereas DETC augmented, the angiotensin II-induced CSAR enhancement.	tempol	22-28	angiotensinogen	Rattus norvegicus	77-91
18071747-3	2008	In this study, we investigated the expression of the rat CA IX in response to chronic hypoxia and to treatment with chemical compounds that disrupt oxygen sensing, including dimethyloxalylglycine, dimethylester succinate, diazoxide, and tempol.	tempol	237-243	carbonic anhydrase 9	Homo sapiens	57-62
18386218-2	2008	METHODS: We examined the reactivity of cerebral arterioles in adult and aged Fisher-344 rats to endothelial nitric oxide synthase (eNOS)-dependent (acetylcholine and adenosine diphosphate [ADP]) and-independent (nitroglycerin) agonists before and during application of tempol, apocynin, and diphenyleneiodonium chloride (DPI).	tempol	269-275	nitric oxide synthase 3	Rattus norvegicus	131-135
17920721-5	2008	The activity of SOD was down-regulated, but the activity of catalase was up-regulated by pyrogallol at 72 h. ROS scavengers, including Tempol, Tiron, Trimetazidine, and N-acetylcysteine (NAC), did not reduce the levels of the intracellular O2*-.	tempol	135-141	catalase	Homo sapiens	60-68
18024543-6	2008	In mesenteric arterioles of the Cu,Zn-SOD(-/-) mice, Tempol, an SOD mimetic, significantly increased the ACh-induced vasodilatation, and the enhancing effect of Tempol was decreased by catalase.	tempol	53-59	superoxide dismutase 1, soluble	Mus musculus	32-41
18024543-6	2008	In mesenteric arterioles of the Cu,Zn-SOD(-/-) mice, Tempol, an SOD mimetic, significantly increased the ACh-induced vasodilatation, and the enhancing effect of Tempol was decreased by catalase.	tempol	53-59	superoxide dismutase 1, soluble	Mus musculus	38-41
17901243-4	2007	In addition, treatment of the cerebral microcirculation with tempol (1 h before infusion of nicotine) prevented nicotine-induced impairment in nNOS-dependent vasodilatation.	tempol	61-67	nitric oxide synthase 1	Rattus norvegicus	143-147
17875968-9	2007	Finally, treatment with Tempol, a superoxide dismutase mimetic, and insulin, both of which reduced the ONOO- formation, markedly reduced diabetes-enhanced LKB1-Ser428 phosphorylation, PTEN, and apoptosis in the endothelium of mouse aortas.	tempol	24-30	serine/threonine kinase 11	Mus musculus	155-159
17875968-9	2007	Finally, treatment with Tempol, a superoxide dismutase mimetic, and insulin, both of which reduced the ONOO- formation, markedly reduced diabetes-enhanced LKB1-Ser428 phosphorylation, PTEN, and apoptosis in the endothelium of mouse aortas.	tempol	24-30	phosphatase and tensin homolog	Mus musculus	184-188
17652361-6	2007	ANG II increased retinal leukostasis from 0.3 +/- 0.5 to 3.7 +/- 0.4 leukocytes/ mm(2) (P &lt; 0.01), and these changes were markedly decreased by treatment with tempol + NAC or apocynin, and also by a blocking antibody against vascular endothelial growth factor given intravitreally (P &lt; 0.01).	tempol	162-168	angiotensinogen	Rattus norvegicus	0-6
17525390-10	2007	Tempol, a superoxide scavenger, and apocynin, an inhibitor of NADPH oxidase, significantly increased vasodilator responses to ACh and decreased vasodilation to NADPH in apoE(-/-) mice on the high-fat diet.	tempol	0-6	apolipoprotein E	Mus musculus	169-173
17510982-4	2007	Penicillamine hydrochloride (10 microM) partially but significantly (P &lt; 0.05) protected against SIN-1-induced decreases in states III and V. However, a 2.5 microM concentration of tempol was able to significantly antagonize a 4-fold molar excess (10 microM) concentration of SIN-1 as effectively as were higher tempol concentrations, consistent with the likelihood that tempol works by a catalytic mechanism.	tempol	184-190	MAPK associated protein 1	Homo sapiens	100-105
17510982-4	2007	Penicillamine hydrochloride (10 microM) partially but significantly (P &lt; 0.05) protected against SIN-1-induced decreases in states III and V. However, a 2.5 microM concentration of tempol was able to significantly antagonize a 4-fold molar excess (10 microM) concentration of SIN-1 as effectively as were higher tempol concentrations, consistent with the likelihood that tempol works by a catalytic mechanism.	tempol	315-321	MAPK associated protein 1	Homo sapiens	100-105
17538186-6	2007	However, the effect of low K intake on ROMK channel activity was significantly attenuated in the CCD from gp91(-/-) mice and completely abolished by tempol treatment.	tempol	149-155	potassium inwardly-rectifying channel, subfamily J, member 1	Mus musculus	39-43
17200434-10	2007	In addition, proteinuria, podocyte damage, and Sgk1 upregulation were significantly alleviated by tempol, a membrane-permeable superoxide dismutase, suggesting the pathogenic role of oxidative stress.	tempol	98-104	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	47-51
17490678-13	2007	In conclusion, tempol treatment reduced morphological and molecular evidence of cardiac hypertrophy in the GLUT4-knockout insulin-resistant mouse in vivo, even at doses insufficient to lower cardiac superoxide.	tempol	15-21	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	107-112
17237245-6	2007	After 8 wk of treatment with the superoxide scavenger Tempol, 12-wk-old db/db mice had lower superoxide production, reduced plasma glucose and lipids, and lower BMP-4 and OPN protein expression when compared with nontreated mice.	tempol	54-60	bone morphogenetic protein 4	Mus musculus	161-166
17237245-6	2007	After 8 wk of treatment with the superoxide scavenger Tempol, 12-wk-old db/db mice had lower superoxide production, reduced plasma glucose and lipids, and lower BMP-4 and OPN protein expression when compared with nontreated mice.	tempol	54-60	secreted phosphoprotein 1	Mus musculus	171-174
17320767-5	2007	Glucose-mediated decreases in PKG-I levels were inhibited by a superoxide scavenger (tempol) or NAD(P)H oxidase inhibitors (diphenylene iodonium or apocynin).	tempol	85-91	protein kinase cGMP-dependent 1	Rattus norvegicus	30-35
16905596-7	2006	Resistin had no effect on dihydroethidium fluorescence, an indicator of superoxide (O(2)(-)) production, and the inhibitory effect of resistin on bradykinin-induced relaxation persisted in the presence of Tempol, a superoxide dismutase mimetic.	tempol	205-211	kininogen 1	Canis lupus familiaris	146-156
17112788-8	2007	In additional experiments, we used the bradykinin B(2) antagonist, icatibant to determine if increased B(2) receptor contributes to the anti-hypertensive effect of combined tempol and enalapril in Ang II-infused rats.	tempol	173-179	angiotensinogen	Rattus norvegicus	197-203
17261958-6	2007	Tempol treatment stimulated SOD activity and increased the conversion of superoxide to hydrogen peroxide, and hydrogen peroxide on its hand was converted to hypochlorite by the increased MPO.	tempol	0-6	myeloperoxidase	Rattus norvegicus	187-190
17200441-7	2007	HHcy significantly decreased bradykinin- or carbachol-induced reduction of myocardial oxygen consumption in vitro, and this effect was completely restored by coincubation with ascorbic acid, Tempol, or apocynin.	tempol	191-197	kininogen 1	Canis lupus familiaris	29-39
17200442-10	2007	Administration of the superoxide scavenger TEMPOL, NAD(P)H oxidase inhibitor (apocynin), or anti-TNF restored endothelium-dependent dilation in Lepr(db) mice.	tempol	43-49	leptin receptor	Mus musculus	144-148
16989807-4	2006	Pretreatment of PC12 cells with 500 microM Tempol, 1 h before induction of the MPP+ insult, reduced by 70% the release of LDH into the medium, inhibited caspase-3 activity by 30% and improved by 33% mitochondrial function, effects correlated with a 70% reduction in ERK1 and ERK2 phosphorylation activity.	tempol	43-49	caspase 3	Rattus norvegicus	153-162
17043164-7	2006	The impaired response to acetylcholine in old CuZnSOD(+/-) mice was restored toward normal with either tempol (a scavenger of superoxide; 1 mmol/L) or PJ34 (an inhibitor of poly-ADP-ribose polymerase; 3 micromol/L).	tempol	103-109	superoxide dismutase 1, soluble	Mus musculus	46-53
16860001-6	2006	Addition of TEMPOL caused a decrease in angiotensin II-induced contraction only in the patients" group.	tempol	12-18	angiotensinogen	Homo sapiens	40-54
16989807-4	2006	Pretreatment of PC12 cells with 500 microM Tempol, 1 h before induction of the MPP+ insult, reduced by 70% the release of LDH into the medium, inhibited caspase-3 activity by 30% and improved by 33% mitochondrial function, effects correlated with a 70% reduction in ERK1 and ERK2 phosphorylation activity.	tempol	43-49	mitogen activated protein kinase 3	Rattus norvegicus	266-270
16989807-4	2006	Pretreatment of PC12 cells with 500 microM Tempol, 1 h before induction of the MPP+ insult, reduced by 70% the release of LDH into the medium, inhibited caspase-3 activity by 30% and improved by 33% mitochondrial function, effects correlated with a 70% reduction in ERK1 and ERK2 phosphorylation activity.	tempol	43-49	mitogen activated protein kinase 1	Rattus norvegicus	275-279
16919817-15	2006	Tert-BuOOH coadminstration reversed the TEMPOL-induced analgesia in the tonic intraplantar formalin response reduction.	tempol	40-46	telomerase reverse transcriptase	Mus musculus	0-4
17008608-9	2006	Tempol (1 mmol/L), a scavenger of superoxide, restored the impaired dilator responses in ECSOD-/- mice.	tempol	0-6	superoxide dismutase 3, extracellular	Mus musculus	89-94
17031260-3	2006	The objective of this study was to investigate the protective effect of the coadministration of NCX-4016 [2-(acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester] (an NO donor) with antioxidants Tempol, superoxide dismutase (SOD), or urate on I/R injury.	tempol	196-202	solute carrier family 8 member A1	Rattus norvegicus	96-99
17031260-8	2006	The treatment of hearts with NCX-4016 + Tempol showed significantly enhanced NO generation and decreased ROS and dityrosine (a marker of peroxynitrite) formation.	tempol	40-46	solute carrier family 8 member A1	Rattus norvegicus	29-32
16756681-0	2006	The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells.	tempol	25-31	plasminogen activator, urokinase receptor	Homo sapiens	60-64
16756681-5	2006	Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL) to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours.	tempol	37-80	plasminogen activator, urokinase receptor	Homo sapiens	133-137
16756681-5	2006	Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL) to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours.	tempol	82-88	plasminogen activator, urokinase receptor	Homo sapiens	133-137
16722034-11	2006	BQ-788, TEMPOL, and DPI inhibited mRNA expression of FN induced by ET-1.	tempol	8-14	fibronectin 1	Homo sapiens	53-55
16627014-3	2006	Bovine pancreatic trypsin inhibitor (BPTI) was used as a model system for aggregation by analyzing its interaction with TEMPOL and Gd(III)DTPA-BMA.	tempol	120-126	spleen trypsin inhibitor I	Bos taurus	0-35
16627014-3	2006	Bovine pancreatic trypsin inhibitor (BPTI) was used as a model system for aggregation by analyzing its interaction with TEMPOL and Gd(III)DTPA-BMA.	tempol	120-126	spleen trypsin inhibitor I	Bos taurus	37-41
16722034-11	2006	BQ-788, TEMPOL, and DPI inhibited mRNA expression of FN induced by ET-1.	tempol	8-14	endothelin 1	Homo sapiens	67-71
16106039-3	2006	In ANG II-treated hypertensive rats, tempol caused increases in medullary (13 +/- 2%), cortical (5 +/- 2%), and total renal blood flow (9 +/- 2%) without altering systemic arterial pressure.	tempol	37-43	angiotensinogen	Rattus norvegicus	3-9
16530186-6	2006	Our results suggest that GSK3beta together with 14-3-3 protein plays essential roles in the signaling of diabetic cardiomyopathy, and treatment with either losartan or tempol prevents these changes.	tempol	168-174	glycogen synthase kinase 3 beta	Mus musculus	25-33
16391834-8	2006	Edaravone and tempol suppressed the serum IL-6 levels, and significantly suppressed the increased colonic MPO levels.	tempol	14-20	interleukin 6	Mus musculus	42-46
16391834-8	2006	Edaravone and tempol suppressed the serum IL-6 levels, and significantly suppressed the increased colonic MPO levels.	tempol	14-20	myeloperoxidase	Mus musculus	106-109
16412660-0	2006	Effect of tempol on altered angiotensin II and acetylcholine-mediated vascular responses in thoracic aorta isolated from rats with insulin resistance.	tempol	10-16	angiotensinogen	Rattus norvegicus	28-42
16412660-4	2006	In this regard, the effect of tempol (a membrane permeable superoxide dismutase mimetic/free radical scavenger) on the enhanced Ang II-induced contraction and impaired-ACh mediated relaxation in thoracic aorta of rats with insulin resistance was studied.	tempol	30-36	angiotensinogen	Rattus norvegicus	128-134
16412660-10	2006	Tempol (30-300 microM) significantly and dose dependently inhibited enhanced vascular responses (E(max)) of Ang II in endothelium intact, but not in endothelium denuded aortic ring preparations.	tempol	0-6	angiotensinogen	Rattus norvegicus	108-114
16106039-7	2006	Tempol infusion also significantly decreased 8-isoprostane excretion in ANG II-treated rats (39 +/- 6%) without changes in H2O2 excretion.	tempol	0-6	angiotensinogen	Rattus norvegicus	72-78
16033921-20	2005	We conclude that in SHR, tempol has a significant renal vasodilator effect and that it normalizes the increased renovascular ANG II sensitivity.	tempol	25-31	angiotensinogen	Rattus norvegicus	125-131
16316329-4	2005	ROS generation was measured by dichlorofluorescein fluorescence using confocal microscopy and was inhibited by transfection of antisense against NADPH subunits p22(phox) or p47(phox) or with Tempol.	tempol	191-197	NSFL1 cofactor	Rattus norvegicus	173-176
15941780-12	2005	In conclusion, the results obtained indicate that the activity of SOD, GPX, and GR in renal and cardiac tissues is decreased in hyperthyroidism and that antioxidant treatment with tempol ameliorates T4-induced hypertension.	tempol	180-186	glutathione-disulfide reductase	Rattus norvegicus	80-82
16153615-7	2005	The effect of Ang II on the CSAR was completely inhibited by pretreatment with either tempol or tiron (P &lt; 0.05) but was not affected by DETC.	tempol	86-92	angiotensinogen	Rattus norvegicus	14-20
16151022-6	2005	Functionally, Ang II-elicited pressor response in the RVLM was attenuated by DPI, tempol, or a p38 MAPK inhibitor, SB203580.	tempol	82-88	angiotensinogen	Homo sapiens	14-20
16100121-8	2005	TEMPOL also abrogated the inhibitory effect of 15-A2-IsoPs on lipopolysaccharide-induced NF-kappaB activation, inducible nitricoxide synthase expression, and nitrite production, suggesting that 15-A2-IsoPs inhibit the NF-kappaB pathway at least partially via a redox-dependent mechanism.	tempol	0-6	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-98
16100121-8	2005	TEMPOL also abrogated the inhibitory effect of 15-A2-IsoPs on lipopolysaccharide-induced NF-kappaB activation, inducible nitricoxide synthase expression, and nitrite production, suggesting that 15-A2-IsoPs inhibit the NF-kappaB pathway at least partially via a redox-dependent mechanism.	tempol	0-6	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	218-227
16153615-10	2005	The effect of Ang II on the RSNA and MAP was abolished by pretreatment with either tempol or tiron but was not affected by DETC.	tempol	83-89	angiotensinogen	Rattus norvegicus	14-20
16243586-6	2005	Treatment with TEMPOL, human superoxide dismutase, diphenyleneiodonium, oxypurinol, NG-monomethyl L-arginine considerably decreased contractile response to angiotensin II in radial arteries.	tempol	15-21	angiotensinogen	Homo sapiens	156-170
15913657-13	2005	Co-treatment with either tempol or apocynin normalized 8-isoprostanes, MDA+4-HNE, aconitase activity, nitrotyrosine, as well as urinary excretion of NO(x), cGMP and sodium in rats receiving leptin.	tempol	25-31	leptin	Rattus norvegicus	190-196
15833798-8	2005	Superoxide scavenging by Tempol treatment inhibited both the Bax-positive index as well as the apoptotic index of medial SMC in response to vascular injury.	tempol	25-31	BCL2 associated X, apoptosis regulator	Rattus norvegicus	61-64
15888486-1	2005	We previously demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) increased latency to tumorigenesis and doubled (100%) the lifespan of Atm-deficient mice, a mouse model of ataxia telangiectasia, which displays accelerated oxidative damage and stress.	tempol	58-64	ataxia telangiectasia mutated	Mus musculus	184-187
15879008-3	2005	Because oxidative stress is increased in diabetes and has been shown to induce COX-2, we assessed its contribution to prostaglandin release by treating diabetic rats with tempol (120 mg/kg/day) for 28 days.	tempol	171-177	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	79-84
15888486-1	2005	We previously demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) increased latency to tumorigenesis and doubled (100%) the lifespan of Atm-deficient mice, a mouse model of ataxia telangiectasia, which displays accelerated oxidative damage and stress.	tempol	66-113	ataxia telangiectasia mutated	Mus musculus	184-187
15864528-10	2005	Plasma concentrations of adiponectin and adipose tissue levels of adiponectin mRNA were decreased in AngII-infused rats, and this effect was prevented by cotreatment with tempol or BH4.	tempol	171-177	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	25-36
15888486-3	2005	However, the relatively small effect on latency in p53-deficient mice and the finding that tempol-mediated resistance to oxidative insult was p53-dependent suggested a more direct role of p53 in the chemopreventative effects of tempol.	tempol	91-97	transformation related protein 53, pseudogene	Mus musculus	142-145
15888486-3	2005	However, the relatively small effect on latency in p53-deficient mice and the finding that tempol-mediated resistance to oxidative insult was p53-dependent suggested a more direct role of p53 in the chemopreventative effects of tempol.	tempol	91-97	transformation related protein 53, pseudogene	Mus musculus	142-145
15888486-5	2005	Inhibition of phosphoinositide 3-kinase (PI3K) family members suggested that SMG-1 was responsible for the tempol-mediated enhancement of p53 serine 18 phosphorylation.	tempol	107-113	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Mus musculus	77-82
15888486-5	2005	Inhibition of phosphoinositide 3-kinase (PI3K) family members suggested that SMG-1 was responsible for the tempol-mediated enhancement of p53 serine 18 phosphorylation.	tempol	107-113	transformation related protein 53, pseudogene	Mus musculus	138-141
15888486-6	2005	These data suggest that the chemopreventative effect of tempol is not solely due to the reduction of oxidative stress and damage but may also be related to redox-mediated signaling functions that include p53 pathway activation.	tempol	56-62	transformation related protein 53, pseudogene	Mus musculus	204-207
15864528-10	2005	Plasma concentrations of adiponectin and adipose tissue levels of adiponectin mRNA were decreased in AngII-infused rats, and this effect was prevented by cotreatment with tempol or BH4.	tempol	171-177	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	66-77
15864528-10	2005	Plasma concentrations of adiponectin and adipose tissue levels of adiponectin mRNA were decreased in AngII-infused rats, and this effect was prevented by cotreatment with tempol or BH4.	tempol	171-177	angiotensinogen	Rattus norvegicus	101-106
15864528-11	2005	The production of superoxide anions (O2-) was significantly increased in the aortae of AngII-treated rats, and this increase was prevented by the administration of tempol or BH4.	tempol	164-170	angiotensinogen	Rattus norvegicus	87-92
15864528-13	2005	Cotreatment of rats with tempol or BH4 reversed AngII-induced increases in NAD(P)H oxidase subunit mRNAs.	tempol	25-31	angiotensinogen	Rattus norvegicus	48-53
15637112-5	2005	Tempol or tiron (superoxide scavengers) increased flow-induced dilation in vessels of Mn-SOD+/- mice.	tempol	0-6	superoxide dismutase 2, mitochondrial	Mus musculus	86-95
15829432-9	2005	Coadministration of Tempol prevented leptin-induced oxidative stress and normalized PON1 activity in aorta and kidney.	tempol	20-26	leptin	Rattus norvegicus	37-43
15829432-9	2005	Coadministration of Tempol prevented leptin-induced oxidative stress and normalized PON1 activity in aorta and kidney.	tempol	20-26	paraoxonase 1	Rattus norvegicus	84-88
15644487-10	2005	Pretreatment of the juxtamedullary afferent arterioles with tempol, a ROS scavenger, or with apocynin, a NADPH oxidase inhibitor, prevented the impaired autoregulation induced by TGF-beta1.	tempol	60-66	transforming growth factor, beta 1	Rattus norvegicus	179-188
15817892-7	2005	Angiotensin II infusion, via AT1 receptor, directly increased brain superoxide by 1.8-fold (P&lt;0.05; n=6 to 7 in each group) and impaired blood-brain barrier in salt-loaded SHRSP by 1.7-fold (P&lt;0.05), and this increase in brain superoxide and blood-brain barrier impairment was prevented by tempol as well as candesartan.	tempol	296-302	angiotensinogen	Rattus norvegicus	0-14
15718491-7	2005	Dihydroethidium staining showed that CRP produced SB203850- and TEMPOL-sensitive superoxide production in the arteriolar endothelium.	tempol	64-70	C-reactive protein	Homo sapiens	37-40
15821440-9	2005	The stimulatory effect of HX/XO on Kir6.1 current was abolished by tempol, a scavenger of O2.	tempol	67-73	potassium inwardly rectifying channel subfamily J member 8	Homo sapiens	35-41
15821440-10	2005	Tempol also abolished the stimulatory effect of 30 muM nicotine on Kir6.1 currents.	tempol	0-6	potassium inwardly rectifying channel subfamily J member 8	Homo sapiens	67-73
15746442-7	2005	Extracellular application of the ROS scavenger, Tempol, attenuated the Ang II-induced increase in neuronal firing rate by 70%.	tempol	48-54	angiotensinogen	Homo sapiens	71-77
15795323-5	2005	TNF-alpha induction was also inhibited by tempol, N-acetylcysteine, or 1,3-dimethyl-2-thiourea.	tempol	42-48	tumor necrosis factor	Mus musculus	0-9
15284074-1	2004	In the present study, we established dose-response relationships between central administration of 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol, a superoxide dismutase mimetic) and the level of renal sympathetic nerve discharge (SND) and tested the hypothesis that intracerebroventricular (icv) Tempol pretreatment would attenuate centrally mediated changes in SND produced by icv ANG II administration.	tempol	99-145	angiotensinogen	Rattus norvegicus	391-397
15734282-3	2005	OBJECTIVE: The goal of this research was to determine the effects of 4-hydroxy-Tempo (Tempol), one of nitroxides, in the presence of UVA1 on cytotoxicity, superoxide dismutase enzyme (SOD) activity, lipid peroxidation, and expression of collagen I, collagen III and MMP-1, MMP-3 in human dermal fibroblasts in vitro.	tempol	86-92	superoxide dismutase 1	Homo sapiens	155-182
15734282-3	2005	OBJECTIVE: The goal of this research was to determine the effects of 4-hydroxy-Tempo (Tempol), one of nitroxides, in the presence of UVA1 on cytotoxicity, superoxide dismutase enzyme (SOD) activity, lipid peroxidation, and expression of collagen I, collagen III and MMP-1, MMP-3 in human dermal fibroblasts in vitro.	tempol	86-92	superoxide dismutase 1	Homo sapiens	184-187
15734282-3	2005	OBJECTIVE: The goal of this research was to determine the effects of 4-hydroxy-Tempo (Tempol), one of nitroxides, in the presence of UVA1 on cytotoxicity, superoxide dismutase enzyme (SOD) activity, lipid peroxidation, and expression of collagen I, collagen III and MMP-1, MMP-3 in human dermal fibroblasts in vitro.	tempol	86-92	matrix metallopeptidase 1	Homo sapiens	266-271
15734282-3	2005	OBJECTIVE: The goal of this research was to determine the effects of 4-hydroxy-Tempo (Tempol), one of nitroxides, in the presence of UVA1 on cytotoxicity, superoxide dismutase enzyme (SOD) activity, lipid peroxidation, and expression of collagen I, collagen III and MMP-1, MMP-3 in human dermal fibroblasts in vitro.	tempol	86-92	matrix metallopeptidase 3	Homo sapiens	273-278
15591232-7	2005	Microinjection of aminoguanidine or S-methylisothiourea, iNOS inhibitors, or tempol, an antioxidant, significantly attenuated the pressor response evoked by iNOS gene transfer.	tempol	77-83	nitric oxide synthase 2	Rattus norvegicus	157-161
15621051-6	2005	Simultaneous treatment with 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol), a membrane-permeable radical scavenger, completely eliminated the increases of phosphorylated MAP kinases and their upstream elements (Raf-1, Rac-1, ASK-1) as well as the increases of cardiac lipid peroxidation induced by the highest dose of ISO infusion.	tempol	28-71	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	217-222
15621051-6	2005	Simultaneous treatment with 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol), a membrane-permeable radical scavenger, completely eliminated the increases of phosphorylated MAP kinases and their upstream elements (Raf-1, Rac-1, ASK-1) as well as the increases of cardiac lipid peroxidation induced by the highest dose of ISO infusion.	tempol	28-71	Rac family small GTPase 1	Rattus norvegicus	224-229
15621051-6	2005	Simultaneous treatment with 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol), a membrane-permeable radical scavenger, completely eliminated the increases of phosphorylated MAP kinases and their upstream elements (Raf-1, Rac-1, ASK-1) as well as the increases of cardiac lipid peroxidation induced by the highest dose of ISO infusion.	tempol	28-71	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	231-236
15621051-6	2005	Simultaneous treatment with 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol), a membrane-permeable radical scavenger, completely eliminated the increases of phosphorylated MAP kinases and their upstream elements (Raf-1, Rac-1, ASK-1) as well as the increases of cardiac lipid peroxidation induced by the highest dose of ISO infusion.	tempol	73-79	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	217-222
15621051-6	2005	Simultaneous treatment with 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol), a membrane-permeable radical scavenger, completely eliminated the increases of phosphorylated MAP kinases and their upstream elements (Raf-1, Rac-1, ASK-1) as well as the increases of cardiac lipid peroxidation induced by the highest dose of ISO infusion.	tempol	73-79	Rac family small GTPase 1	Rattus norvegicus	224-229
15621051-6	2005	Simultaneous treatment with 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol), a membrane-permeable radical scavenger, completely eliminated the increases of phosphorylated MAP kinases and their upstream elements (Raf-1, Rac-1, ASK-1) as well as the increases of cardiac lipid peroxidation induced by the highest dose of ISO infusion.	tempol	73-79	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	231-236
15601469-7	2004	Finally, we evaluated the effect of pre-treatment with the piperidine nitroxide Tempol (TPL), an agent that was reported to induce p21 expression irrespective of p53 status, on the cytotoxicity of DOX in the four cell lines.	tempol	88-91	H3 histone pseudogene 16	Homo sapiens	131-134
15637297-9	2005	The attenuated bradykinin-induced reduction in MVO2 in nNOS-/- was restored by preincubation with Tiron, ascorbic acid, Tempol, oxypurinol, or SB203850, an inhibitor of p38 kinase, but not apocynin.	tempol	120-126	nitric oxide synthase 1, neuronal	Mus musculus	55-59
15601469-11	2004	RESULTS: Our results indicate that, in the colon carcinoma cell lines tested, sensitivity to DOX is associated with p21 upregulation upon drug exposure, and DOX cytotoxicity is potentiated by pre-treatment with TPL, but only in those cell lines in which p21 can be upregulated.	tempol	211-214	H3 histone pseudogene 16	Homo sapiens	254-257
15284074-1	2004	In the present study, we established dose-response relationships between central administration of 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol, a superoxide dismutase mimetic) and the level of renal sympathetic nerve discharge (SND) and tested the hypothesis that intracerebroventricular (icv) Tempol pretreatment would attenuate centrally mediated changes in SND produced by icv ANG II administration.	tempol	147-153	angiotensinogen	Rattus norvegicus	391-397
15284074-4	2004	Mean arterial pressure and SND values were significantly increased after icv ANG II (150 ng/kg) administration, and these responses were abrogated after icv pretreatment with Tempol (75 micromol/kg) or losartan.	tempol	175-181	angiotensinogen	Rattus norvegicus	77-83
15501693-9	2004	Tempol (100 microM, a cell permeable superoxide dismutase mimetic) partially reduced the augmented Ang II response in HG exposed aortic rings, while it did not affect the Ang II responses in normal glucose (NG 5.5 mM) exposed aortic rings isolated from control rats.	tempol	0-6	angiotensinogen	Rattus norvegicus	99-105
15105383-9	2004	Moreover, 4-hydroxy-2,2,6,6-tetramethyl-piperidine-N-oxyl, a superoxide scavenger mimetic, normalized the insulin resistance induced by Ang II without affecting the blood pressure in both groups.	tempol	10-57	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	136-142
15477016-8	2004	Tempol alone did not induce cytotoxicity, yet did increase cleaved PARP levels.	tempol	0-6	poly(ADP-ribose) polymerase 1	Homo sapiens	67-71
15213104-3	2004	We tested this hypothesis by determining whether the well-described nitroxide antioxidant, tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), acts as a chemopreventative agent in Atm mutant mice, a model of the human cancer prone syndrome ataxia-telangiectasia.	tempol	91-97	ataxia telangiectasia mutated	Mus musculus	185-188
15213104-3	2004	We tested this hypothesis by determining whether the well-described nitroxide antioxidant, tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), acts as a chemopreventative agent in Atm mutant mice, a model of the human cancer prone syndrome ataxia-telangiectasia.	tempol	99-145	ataxia telangiectasia mutated	Mus musculus	185-188
15490413-4	2004	The functional significance of these findings was confirmed by favorable response to administration of the cell-permeable SOD-mimetic agent, tempol, in CRF rats.	tempol	141-147	superoxide dismutase 1	Homo sapiens	122-125
15493454-10	2004	Treatment of mice with Tempol caused a significant inhibition of carrageenan-induced IkappaB-alpha degradation and NF-kappaB/DNA binding activity.	tempol	23-29	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	85-98
15132300-4	2004	Under angiotensin II-induced constriction, tempol (3 mmol/L) caused 57 +/- 8% dilation of afferent arterioles.	tempol	43-49	angiotensinogen	Rattus norvegicus	6-20
15096451-5	2004	In AM+/+ mice, hypoxia enhanced AM mRNA expression, which was reduced by the administration of a superoxide dismutase mimetic, 4-hydroxy-2,2,6,6-tetramethyl-piperidine-N-oxyl (hydroxy-TEMPO).	tempol	127-174	adrenomedullin	Mus musculus	3-5
15096451-5	2004	In AM+/+ mice, hypoxia enhanced AM mRNA expression, which was reduced by the administration of a superoxide dismutase mimetic, 4-hydroxy-2,2,6,6-tetramethyl-piperidine-N-oxyl (hydroxy-TEMPO).	tempol	127-174	adrenomedullin	Mus musculus	32-34
15117817-4	2004	Affs from Ang II 200 rabbits had increased (P&lt;0.01) mRNA for COX-2 and enhanced vasoconstriction to Ang II, U-46 619 (TP-R mimetic), and endothelin-1 that was normalized by ifetroban plus tempol together.	tempol	191-197	endothelin-1	Oryctolagus cuniculus	140-152
15167449-6	2004	Pre-treatment with Tiron and Tempol, *O2 scavengers, attenuated agonist-stimulated phosphorylation of p38MAPK, c-Jun N-terminal kinases (JNK) and ERK5, but not of ERK1/2 (extracellular signal-regulated kinases).	tempol	29-35	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-116
15167449-6	2004	Pre-treatment with Tiron and Tempol, *O2 scavengers, attenuated agonist-stimulated phosphorylation of p38MAPK, c-Jun N-terminal kinases (JNK) and ERK5, but not of ERK1/2 (extracellular signal-regulated kinases).	tempol	29-35	mitogen-activated protein kinase 8	Homo sapiens	137-140
15167449-6	2004	Pre-treatment with Tiron and Tempol, *O2 scavengers, attenuated agonist-stimulated phosphorylation of p38MAPK, c-Jun N-terminal kinases (JNK) and ERK5, but not of ERK1/2 (extracellular signal-regulated kinases).	tempol	29-35	mitogen-activated protein kinase 7	Homo sapiens	146-150
15167449-6	2004	Pre-treatment with Tiron and Tempol, *O2 scavengers, attenuated agonist-stimulated phosphorylation of p38MAPK, c-Jun N-terminal kinases (JNK) and ERK5, but not of ERK1/2 (extracellular signal-regulated kinases).	tempol	29-35	mitogen-activated protein kinase 3	Homo sapiens	163-169
14975764-11	2004	Tempol (14+/-3) but not hydralazine (32+/-5) treatment prevented the intrarenal angiotensinogen augmentation.	tempol	0-6	angiotensinogen	Rattus norvegicus	80-95
14753451-5	2003	The endothelial H2O2-stimulated Ca2+ mobilization and cytoskeleton (vimentin) rearrangement was modified by either 2-AG or TPL.	tempol	123-126	vimentin	Homo sapiens	68-76
14656912-7	2003	Bradykinin (10(-4) mol/L)-induced reduction in MVO2 was reversed in a concentration-dependent manner by angiotensin II (38+/-1% versus 19+/-2% at 10(-8) mol/L) and restored by coincubation of AA (37+/-2%), tempol (33+/-2%), losartan (34+/-2%), or apocynin (36+/-1%).	tempol	206-212	kininogen 1	Canis lupus familiaris	0-10
12885792-7	2003	Moreover, ET-1 treatment (10(-9) mol/L, 10 minutes) of isolated vena cavas further elevated superoxide levels in DOCA-salt rats only but not sham rats, an effect that was abrogated by the superoxide scavenger tempol.	tempol	209-215	endothelin 1	Rattus norvegicus	10-14
12885792-8	2003	Similarly, ET-1-induced contractions of isolated vena cavas of DOCA-salt but not sham rats were significantly inhibited by tempol.	tempol	123-129	endothelin 1	Rattus norvegicus	11-15
12651210-2	2003	Here, we show that Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl; TPL), a stable nitroxide free radical, inhibits the growth of C6 glioma cells both in vitro and in vivo.	tempol	19-25	BPI fold containing family A, member 5	Mus musculus	75-78
12651210-2	2003	Here, we show that Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl; TPL), a stable nitroxide free radical, inhibits the growth of C6 glioma cells both in vitro and in vivo.	tempol	27-73	BPI fold containing family A, member 5	Mus musculus	75-78
12595345-9	2003	Ang II-mediated inhibition was not observed in the presence of L-NMMA or after endothelial removal but was prevented by losartan, superoxide scavenger TEMPOL, or NADPH oxidase inhibitor apocynin.	tempol	151-157	angiotensinogen	Homo sapiens	0-6
14694157-7	2004	Addition of the superoxide radical scavenger tempol restored the ability of bradykinin, enalaprilat, and amlodipine to suppress oxygen consumption in tissue from 23-mo-old animals to levels seen in younger animals, suggesting NO destruction by superoxide as the reason for decreased NO availability.	tempol	45-51	kininogen 1	Homo sapiens	76-86
12874096-3	2003	Endothelin-1 (5 pmol/kg per minute) was chronically infused into the jugular vein by use of mini-osmotic pump for 9 days in male Sprague-Dawley rats and in rats treated with the superoxide anion scavenger tempol (30 mg/kg per day).	tempol	205-211	endothelin 1	Rattus norvegicus	0-12
12874096-7	2003	The increase in arterial pressure in response to endothelin-1 was completely abolished by tempol (127+/-4 versus 127+/-4 mm Hg).	tempol	90-96	endothelin 1	Rattus norvegicus	49-61
12874096-9	2003	Tempol also significantly decreased the level of 8-isoprostaglandin F2alpha in the endothelin-1-treated rats.	tempol	0-6	endothelin 1	Rattus norvegicus	83-95
12498984-6	2003	Selected tissues from Tempol-treated animals exhibited elevated levels of mitochrondrial uncoupling protein-2 (UCP-2) and HSP70.	tempol	22-28	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	89-109
12498984-6	2003	Selected tissues from Tempol-treated animals exhibited elevated levels of mitochrondrial uncoupling protein-2 (UCP-2) and HSP70.	tempol	22-28	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	111-116
12498984-6	2003	Selected tissues from Tempol-treated animals exhibited elevated levels of mitochrondrial uncoupling protein-2 (UCP-2) and HSP70.	tempol	22-28	heat shock protein 1B	Mus musculus	122-127
11176168-5	2001	Tempol also attenuated the lung, liver, and intestinal injury (histology) as well as the increase in the concentrations of myeloperoxidase and malondialdehyde caused by zymosan in the lung, liver, and intestine.	tempol	0-6	myeloperoxidase	Rattus norvegicus	123-138
12131535-2	2002	METHODS: The effect of the superoxide dismutase mimetic, 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (tempol), on responses to angiotensin II (Ang II), endothelin-1, phenylephrine and potassium chloride was determined in aortic rings and perfused mesenteric vascular beds (MVB) of adult male rats of the Sprague-Dawley, Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) strains.	tempol	102-108	angiotensinogen	Rattus norvegicus	127-141
12131535-2	2002	METHODS: The effect of the superoxide dismutase mimetic, 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (tempol), on responses to angiotensin II (Ang II), endothelin-1, phenylephrine and potassium chloride was determined in aortic rings and perfused mesenteric vascular beds (MVB) of adult male rats of the Sprague-Dawley, Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) strains.	tempol	102-108	angiotensinogen	Rattus norvegicus	143-149
12131535-3	2002	The effect of tempol on Ang II-evoked superoxide production was assessed in aortic rings.	tempol	14-20	angiotensinogen	Rattus norvegicus	24-30
12131535-9	2002	A significant increase in lucigenin chemiluminescence evoked by Ang II in both intact and endothelium-denuded aortic rings of SHRs was abolished when tempol was included in the buffer.	tempol	150-156	angiotensinogen	Rattus norvegicus	64-70
11566905-15	2001	Western blotting for nNOS in kidney cortex and medulla showed a protein increase in both fractions of 1K1C versus controls and was normalized by losartan plus tempol treatment.	tempol	159-165	nitric oxide synthase 1	Rattus norvegicus	21-25
11230275-6	2001	Cotreatment with either tempol or lazaroid abrogated the lead-induced upregulation of eNOS protein and NO(x) production.	tempol	24-30	nitric oxide synthase 3	Homo sapiens	86-90
12162455-15	2002	The increased levels of total antioxidants in the serum and catalase in BAL fluid correlated with the reduction in the clearance rate for TEMPOL, suggesting that a change in the redox status of the lung is associated with lung injury induced by asbestos.	tempol	138-144	catalase	Mus musculus	60-68
11566950-11	2001	Both tempol and vitamin E prevented Ang II-induced hypertension and either prevented or tended to blunt the increase in systemic and renal isoprostanes, TBARS, and ET.	tempol	5-11	angiotensinogen	Rattus norvegicus	36-42
11208760-14	2001	In Ang II-infused rats, tempol did not affect regional blood flow but significantly decreased vascular resistance in the brain (29+/-6%), heart (31+/-6%), liver (37+/-7%), kidney (30+/-7%), small intestine (38+/-6%), and large intestine (47+/-7%).	tempol	24-30	angiotensinogen	Rattus norvegicus	3-9
11208760-15	2001	Ang II-infused hypertensive rats showed doubled vascular superoxide production (assessed with lucigenin chemiluminescence), which was normalized by treatment with tempol (3 mmol/L, n=7).	tempol	163-169	angiotensinogen	Rattus norvegicus	0-6
11011044-11	2000	Tempol also reduced the appearance of nitrotyrosine and poly (ADP-ribose) synthetase immunoreactivity in the colon as well as the up-regulation of ICAM-1 and P-selectin.	tempol	0-6	intercellular adhesion molecule 1	Rattus norvegicus	147-153
11011044-11	2000	Tempol also reduced the appearance of nitrotyrosine and poly (ADP-ribose) synthetase immunoreactivity in the colon as well as the up-regulation of ICAM-1 and P-selectin.	tempol	0-6	selectin P	Rattus norvegicus	158-168
10967303-7	2000	In gerbils subjected to BCO, which were treated with tempol, the degree of staining for nitrotyrosine and PARS was markedly reduced.	tempol	53-59	poly(ADP-ribose) polymerase 1	Homo sapiens	106-110
11033415-1	2000	The antiproliferative effect of Tempol, a stable nitroxide free radical, was investigated on the p53-negative human leukemia cell line HL60.	tempol	32-38	tumor protein p53	Homo sapiens	97-100
9839944-6	1998	The presence of surface hydrophobic residues is confirmed by selective broadening of ethyl and aromatic signals in the 1H-NMR spectrum on the addition of the paramagnetic probe 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-N-oxy, OH-TEMPO, to wild-type TIMP-1.	tempol	177-223	TIMP metallopeptidase inhibitor 1	Homo sapiens	248-254
10839200-8	2000	Cytokine induced release of MCP-1 and IL-6 by endothelial cells was completely inhibited in the presence of Tiron and Tempol, whereas NMMA was less effective.	tempol	118-124	mast cell protease 1	Mus musculus	28-33
10839200-8	2000	Cytokine induced release of MCP-1 and IL-6 by endothelial cells was completely inhibited in the presence of Tiron and Tempol, whereas NMMA was less effective.	tempol	118-124	interleukin 6	Mus musculus	38-42
8543588-5	1996	However, on co-incubation with tempol, an inhibitor of the one-electron reduction pathway, the sensitivity of PC-9/MC4 to MMC was impaired under hypoxic conditions, but the impairment was not evident under aerobic conditions.	tempol	31-37	proprotein convertase subtilisin/kexin type 9	Homo sapiens	110-114
9831920-3	1998	Here we investigate (i) the effects of endotoxin on the expression of two isoforms of superoxide dismutase (SOD), namely Cu/Zn-SOD (cytosol) and Mn-SOD (mitochondria) in the rat kidney, and (ii) the effects of the radical scavenger tempol on the MODS caused by lipopolysaccharide (LPS, E. coli, 6 mg kg(-1) i.v.)	tempol	232-238	superoxide dismutase 1	Rattus norvegicus	108-111
9098095-7	1997	A full radiation dose-response experiment revealed a tumor control dose in 50% of the animals in 30 d (TCD(50/30)) value of 36.7 Gy for Tempol-treated mice and 41.8 Gy for saline-treated mice suggesting no protection of the RIF-1 tumor by Tempol.	tempol	136-142	replication timing regulatory factor 1	Mus musculus	224-229
9098095-10	1997	Bioreduction of Tempol to its corresponding hydroxylamine (which is not a radioprotector) occurred to a greater extent in RIF-1 tumor cells compared to bone marrow.	tempol	16-22	replication timing regulatory factor 1	Mus musculus	122-127
7590435-6	1995	Intragastric administration of TEMPOL, 0.5 g/kg/bw, immediately after intracaecal administration of 5% acetic acid significantly decreased mucosal lesion area, myeloperoxidase activity, and leukotriene B4 and C4 generation when assessed 24 hours after damage induction.	tempol	31-37	myeloperoxidase	Homo sapiens	160-175
7590435-7	1995	Intragastric administration of TEMPOL, 0.5 g/kg/bw, immediately after intracolonic administration of 30 mg TNB in 0.25 ml 50% ethanol, and once daily thereafter, significantly decreased mucosal lesion area assessed after one, three, and seven days, having no effect on LTC4 generation and affecting colonic weight, myeloperoxidase activity, and LTB4 generation only sporadically.	tempol	31-37	myeloperoxidase	Homo sapiens	315-330
7613465-1	1995	The paramagnetic relaxation reagent, 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxy (HyTEMPO), was used to probe the surface exposure of methionine residues of recombinant cardiac troponin C (cTnC) in the absence and presence of Ca2+ at the regulatory site (site II), as well as in the presence of the troponin I inhibitory peptide (cTnIp).	tempol	37-83	troponin C1, slow skeletal and cardiac type	Homo sapiens	172-190
7613465-1	1995	The paramagnetic relaxation reagent, 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxy (HyTEMPO), was used to probe the surface exposure of methionine residues of recombinant cardiac troponin C (cTnC) in the absence and presence of Ca2+ at the regulatory site (site II), as well as in the presence of the troponin I inhibitory peptide (cTnIp).	tempol	37-83	troponin C1, slow skeletal and cardiac type	Homo sapiens	192-196
19920565-7	1994	Treatment of the cells with TEMPOL prevented H2O2-induced inhibition of growth, formation of single-strand breaks in DNA, activation of the DNA-repair enzyme poly-ADP-ribose polymerase, and decrease in NAD, but TEMPOL was not able to prevent other changes such as the loss of GSH, decrease in glyceraldehyde-3-phosphate dehydrogenase activity, and stimulation of the shunt.	tempol	28-34	LOC786101	Bos taurus	293-333
1551104-2	1992	The stable nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (Tempol) has recently been shown to protect aerated cells in culture against superoxide generated from hypoxanthine/xanthine oxidase, hydrogen peroxide, and radiation-induced cytotoxicity and to modestly sensitive hypoxic cultured cells.	tempol	21-67	xanthine dehydrogenase	Mus musculus	184-200
1551104-2	1992	The stable nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (Tempol) has recently been shown to protect aerated cells in culture against superoxide generated from hypoxanthine/xanthine oxidase, hydrogen peroxide, and radiation-induced cytotoxicity and to modestly sensitive hypoxic cultured cells.	tempol	69-75	xanthine dehydrogenase	Mus musculus	184-200
2038186-2	1991	We investigated the ability of a stable nitroxide spin trap, TEMPOL, to protect TNF-sensitive cells from exogenously added TNF.	tempol	61-67	tumor necrosis factor	Mus musculus	80-83
2038186-2	1991	We investigated the ability of a stable nitroxide spin trap, TEMPOL, to protect TNF-sensitive cells from exogenously added TNF.	tempol	61-67	tumor necrosis factor	Mus musculus	123-126
15374470-7	1990	This statement has been proven by showing (i) that O2* radicals generated during the autoxidation of ID-H can directly be trapped on DMPO; (ii) the effect of ID-H on the OH* free radicals is abolished if SOD is added to the system; (iii) the O2(-*) radicals generated by ID-H autoxidation reduce directly the OH-spin adducts on various kinds of nitroxide type spin traps (e.g. TEMPO, TMPN).	tempol	384-388	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	101-105
15374470-7	1990	This statement has been proven by showing (i) that O2* radicals generated during the autoxidation of ID-H can directly be trapped on DMPO; (ii) the effect of ID-H on the OH* free radicals is abolished if SOD is added to the system; (iii) the O2(-*) radicals generated by ID-H autoxidation reduce directly the OH-spin adducts on various kinds of nitroxide type spin traps (e.g. TEMPO, TMPN).	tempol	384-388	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	158-162
15374470-7	1990	This statement has been proven by showing (i) that O2* radicals generated during the autoxidation of ID-H can directly be trapped on DMPO; (ii) the effect of ID-H on the OH* free radicals is abolished if SOD is added to the system; (iii) the O2(-*) radicals generated by ID-H autoxidation reduce directly the OH-spin adducts on various kinds of nitroxide type spin traps (e.g. TEMPO, TMPN).	tempol	384-388	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	158-162
26820827-6	2016	5-HT-induced elevation of IL-8 at both mRNA and protein levels was observed, which was inhibited by TEMPOL (a free radical scavenger), and inhibitors for p38 MAPK (SB203580) and ERK (U0126), in line with the time-dependent phosphorylation of p38 MAPK and ERK.	tempol	100-106	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
34883252-5	2022	Adipose tissue, from Tempol treated mice, was analyzed using targeted gene microarrays revealing up-regulation of fatty acid metabolism genes (Acadm and Acadl > 4-fold, and Acsm3 and Acsm5 > 10-fold).	tempol	21-27	acyl-Coenzyme A dehydrogenase, medium chain	Mus musculus	143-148
34883252-5	2022	Adipose tissue, from Tempol treated mice, was analyzed using targeted gene microarrays revealing up-regulation of fatty acid metabolism genes (Acadm and Acadl > 4-fold, and Acsm3 and Acsm5 > 10-fold).	tempol	21-27	acyl-CoA synthetase medium-chain family member 3	Mus musculus	173-178
34883252-5	2022	Adipose tissue, from Tempol treated mice, was analyzed using targeted gene microarrays revealing up-regulation of fatty acid metabolism genes (Acadm and Acadl > 4-fold, and Acsm3 and Acsm5 > 10-fold).	tempol	21-27	acyl-CoA synthetase medium-chain family member 5	Mus musculus	183-188