PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31261931-0	2019	Ochratoxin A-Induced Hepatotoxicity through Phase I and Phase II Reactions Regulated by AhR in Liver Cells.	ochratoxin A	0-12	aryl hydrocarbon receptor	Homo sapiens	88-91
30952243-1	2019	In this work, an innovative aptasensor based on electrochemiluminescence resonance energy transfer (ECL-RET) from CdTe quantum dots (QDs) to a cyanine dye (Cy5) fluorophore for the determination of Ochratoxin A (OTA) was fabricated.	ochratoxin A	198-210	ret proto-oncogene	Homo sapiens	104-107
30964496-4	2019	This synergy contributes enormously to the molecular imprinting photoelectrochemical (MIP-PEC) sensor for toxin detection, and the work typically provided a wide linear range of 0.01 to 1000 ng mL-1 with a detection limit of 0.51 pg mL-1 for ochratoxin A (OTA).	ochratoxin A	242-254	L1 cell adhesion molecule	Mus musculus	194-198
30852619-0	2019	Inhibitory effect of ochratoxin A on DNMT-mediated flocculation of yeast.	ochratoxin A	21-33	DNA methyltransferase 1	Homo sapiens	37-41
30291945-0	2018	Renal toxicity through AhR, PXR, and Nrf2 signaling pathway activation of ochratoxin A-induced oxidative stress in kidney cells.	ochratoxin A	74-86	aryl hydrocarbon receptor	Homo sapiens	23-26
30650308-0	2019	Ochratoxin A Exposure Impairs Porcine Granulosa Cell Growth via the PI3K/AKT Signaling Pathway.	ochratoxin A	0-12	AKT serine/threonine kinase 1	Sus scrofa	73-76
30287338-0	2018	Ochratoxin A induces cytoprotective autophagy via blocking AKT/mTOR signaling pathway in PK-15 cells.	ochratoxin A	0-12	AKT serine/threonine kinase 1	Sus scrofa	59-62
30291945-0	2018	Renal toxicity through AhR, PXR, and Nrf2 signaling pathway activation of ochratoxin A-induced oxidative stress in kidney cells.	ochratoxin A	74-86	nuclear receptor subfamily 1 group I member 2	Homo sapiens	28-31
30287338-0	2018	Ochratoxin A induces cytoprotective autophagy via blocking AKT/mTOR signaling pathway in PK-15 cells.	ochratoxin A	0-12	mechanistic target of rapamycin kinase	Sus scrofa	63-67
30291945-0	2018	Renal toxicity through AhR, PXR, and Nrf2 signaling pathway activation of ochratoxin A-induced oxidative stress in kidney cells.	ochratoxin A	74-86	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
30120945-0	2018	Mitigation of cell apoptosis induced by ochratoxin A (OTA) is possibly through organic cation transport 2 (OCT2) knockout.	ochratoxin A	40-52	solute carrier family 22 member 2	Rattus norvegicus	79-105
30170064-0	2018	Activation of AMPK-dependent SIRT-1 by astragalus polysaccharide protects against ochratoxin A-induced immune stress in vitro and in vivo.	ochratoxin A	82-94	sirtuin 1	Mus musculus	29-35
30248419-0	2018	ERK1/2-mediated autophagy is essential for cell survival under Ochratoxin A exposure in IPEC-J2 cells.	ochratoxin A	63-75	mitogen-activated protein kinase 3	Sus scrofa	0-6
30120945-0	2018	Mitigation of cell apoptosis induced by ochratoxin A (OTA) is possibly through organic cation transport 2 (OCT2) knockout.	ochratoxin A	40-52	solute carrier family 22 member 2	Rattus norvegicus	107-111
30338760-2	2018	The fluorescence anisotropy method was used to examine the interactions of commercial human serum albumin (HSA) and human plasma proteins with ochratoxin A (OTA) or carboxylate form of camptothecin (CPT-C).	ochratoxin A	143-155	albumin	Homo sapiens	92-111
30284043-0	2018	SERS based aptasensor for ochratoxin A by combining Fe3O4@Au magnetic nanoparticles and Au-DTNB@Ag nanoprobes with multiple signal enhancement.	ochratoxin A	26-38	dystrobrevin beta	Homo sapiens	91-95
29614475-0	2018	PCV2 infection aggravates ochratoxin A-induced nephrotoxicity via autophagy involving p38 signaling pathway in vivo and in vitro.	ochratoxin A	26-38	mitogen-activated protein kinase 14	Homo sapiens	86-89
29932113-0	2018	Interaction of Ochratoxin A and Its Thermal Degradation Product 2"R-Ochratoxin A with Human Serum Albumin.	ochratoxin A	15-27	albumin	Homo sapiens	92-105
29474583-0	2018	Ochratoxin A, citrinin and deoxynivalenol decrease claudin-2 expression in mouse rectum CMT93-II cells.	ochratoxin A	0-12	claudin 2	Mus musculus	51-60
29799741-0	2018	Combination of Selenomethionine and N-Acetylcysteine Alleviates the Joint Toxicities of Aflatoxin B1 and Ochratoxin A by ERK MAPK Signal Pathway in Porcine Alveolar Macrophages.	ochratoxin A	105-117	mitogen-activated protein kinase 1	Homo sapiens	121-124
29799741-0	2018	Combination of Selenomethionine and N-Acetylcysteine Alleviates the Joint Toxicities of Aflatoxin B1 and Ochratoxin A by ERK MAPK Signal Pathway in Porcine Alveolar Macrophages.	ochratoxin A	105-117	mitogen-activated protein kinase 1	Homo sapiens	125-129
29474583-6	2018	In this study, we examined whether ochratoxin A, citrinin and deoxynivalenol affect claudin-2 expression and ERK1/2 phosphorylation in CMT93-II cells.	ochratoxin A	35-47	claudin 2	Homo sapiens	84-93
29274354-0	2018	Ochratoxin A exposure decreased sperm motility via the AMPK and PTEN signaling pathways.	ochratoxin A	0-12	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	55-59
29274354-0	2018	Ochratoxin A exposure decreased sperm motility via the AMPK and PTEN signaling pathways.	ochratoxin A	0-12	phosphatase and tensin homolog	Homo sapiens	64-68
28456721-2	2017	Significant adenosine triphosphate-dependent uptake by MRP4 was observed for ochratoxin A, pitavastatin, raltitrexed (Km = 43.7 muM), pravastatin, cyclic guanosine monophosphate, 2,4-dichlorophenoxyacetate, and urate.	ochratoxin A	77-89	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	55-59
28590009-0	2018	Effect of rMnSOD on Sodium Reabsorption in Renal Proximal Tubule in Ochratoxin A-Treated Rats.	ochratoxin A	68-80	superoxide dismutase 2	Rattus norvegicus	10-16
29210367-2	2017	We developed a highly sensitive and specific SERS sensor for the detection of ochratoxin A using a simple rough gold film as a substrate.	ochratoxin A	78-90	seryl-tRNA synthetase 1	Homo sapiens	45-49
28732344-1	2018	A label-free photoelectrochemical (PEC) platform with high visible-light activity for quantitative detection of the ochratoxin A (OTA) was developed by assembly of Ag2S nanoparticles (NPs) sensitized on titanium dioxide/red blood cell-like shape bismuth vanadate (TiO2/S-BiVO4) electrode via layer-by-layer (LBL) strategy.	ochratoxin A	116-128	angiotensin II receptor type 1	Homo sapiens	164-168
28710020-0	2017	Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo.	ochratoxin A	28-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
28650663-0	2017	Overexpression and Low Expression of Selenoprotein S Impact Ochratoxin A-Induced Porcine Cytotoxicity and Apoptosis in Vitro.	ochratoxin A	60-72	selenoprotein S	Sus scrofa	37-52
28532671-0	2017	Ochratoxin A transport by the human breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), and organic anion-transporting polypeptides 1A2, 1B1 and 2B1.	ochratoxin A	0-12	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	36-68
28532671-0	2017	Ochratoxin A transport by the human breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), and organic anion-transporting polypeptides 1A2, 1B1 and 2B1.	ochratoxin A	0-12	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	70-74
28532671-0	2017	Ochratoxin A transport by the human breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), and organic anion-transporting polypeptides 1A2, 1B1 and 2B1.	ochratoxin A	0-12	ATP binding cassette subfamily C member 2	Homo sapiens	77-107
28532671-0	2017	Ochratoxin A transport by the human breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), and organic anion-transporting polypeptides 1A2, 1B1 and 2B1.	ochratoxin A	0-12	ATP binding cassette subfamily C member 2	Homo sapiens	109-113
28089712-0	2017	Effect of heme oxygenase-1 on ochratoxin A-induced nephrotoxicity in mice.	ochratoxin A	30-42	heme oxygenase 1	Mus musculus	10-26
28528741-0	2017	In vitro immune toxicity of ochratoxin A in porcine alveolar macrophages: A role for the ROS-relative TLR4/MyD88 signaling pathway.	ochratoxin A	28-40	toll like receptor 4	Homo sapiens	102-106
28528741-0	2017	In vitro immune toxicity of ochratoxin A in porcine alveolar macrophages: A role for the ROS-relative TLR4/MyD88 signaling pathway.	ochratoxin A	28-40	MYD88 innate immune signal transduction adaptor	Homo sapiens	107-112
28602893-8	2017	Exceedance is particularly pronounced for ochratoxin A in the continuous daily intake scenario (29.2 fold above the child adjusted TDI).	ochratoxin A	42-54	TLX1 neighbor	Homo sapiens	131-134
28089712-2	2017	One of the mycotoxin, ochratoxin A (OTA) was previously shown to affect HO-1 expression, however, the mechanisms of OTA-induced nephrotoxicity during HO-1 deficiency are unknown.	ochratoxin A	22-34	heme oxygenase 1	Mus musculus	72-76
27959549-0	2016	A Polyketide Synthase Encoded by the Gene An15g07920 Is Involved in the Biosynthesis of Ochratoxin A in Aspergillus niger.	ochratoxin A	88-100	ANI_1_1528094	Aspergillus niger CBS 513.88	2-21
27924530-5	2017	Aflatoxins B1, B2, G1, G2 are the most toxic and carcinogenic mycotoxins, due to their extreme hepatocarcinogenicity; ochratoxin A is a potent nephrotoxin, it is also carcinogenic, teratogenic, and immunotoxic in rats and possibly in humans; fumonisins are hepatotoxic and nephrotoxic with potential carcinogenic effects on rat and mice.	ochratoxin A	118-130	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	11-25
27959549-1	2016	The polyketide synthase gene An15g07920 was known in Aspergillus niger CBS 513.88 as putatively involved in the production of ochratoxin A (OTA).	ochratoxin A	126-138	ANI_1_1528094	Aspergillus niger CBS 513.88	4-23
26721203-0	2016	Malignant transformation of human gastric epithelium cells via reactive oxygen species production and Wnt/beta-catenin pathway activation following 40-week exposure to ochratoxin A.	ochratoxin A	168-180	catenin beta 1	Homo sapiens	106-118
26866273-5	2016	Blocking the nuclear import of NRF2 using ochratoxin A (OTA) induced the loss of the self-renewal and osteogenic potential of early-passage (EP) MSCs.	ochratoxin A	42-54	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
27193732-0	2016	Ochratoxin A mediates MAPK activation, modulates IL-2 and TNF-alpha mRNA expression and induces apoptosis by mitochondria-dependent and mitochondria-independent pathways in human H9 T cells.	ochratoxin A	0-12	interleukin 2	Homo sapiens	49-53
30090366-0	2016	Mycotoxin ochratoxin A disrupts renal development via a miR-731/prolactin receptor axis in zebrafish.	ochratoxin A	10-22	microRNA 731	Danio rerio	56-63
30090366-0	2016	Mycotoxin ochratoxin A disrupts renal development via a miR-731/prolactin receptor axis in zebrafish.	ochratoxin A	10-22	prolactin receptor a	Danio rerio	64-82
26377828-0	2016	High-Throughput Tag-Sequencing Analysis of Early Events Induced by Ochratoxin A in HepG-2 Cells.	ochratoxin A	67-79	long intergenic non-protein coding RNA 1194	Homo sapiens	16-19
27193732-0	2016	Ochratoxin A mediates MAPK activation, modulates IL-2 and TNF-alpha mRNA expression and induces apoptosis by mitochondria-dependent and mitochondria-independent pathways in human H9 T cells.	ochratoxin A	0-12	tumor necrosis factor	Homo sapiens	58-67
25627963-0	2015	Apoptosis signal-regulating kinase 1 promotes Ochratoxin A-induced renal cytotoxicity.	ochratoxin A	46-58	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	0-36
26341324-0	2015	A food contaminant ochratoxin A suppresses pregnane X receptor (PXR)-mediated CYP3A4 induction in primary cultures of human hepatocytes.	ochratoxin A	19-31	nuclear receptor subfamily 1 group I member 2	Homo sapiens	43-62
26341324-0	2015	A food contaminant ochratoxin A suppresses pregnane X receptor (PXR)-mediated CYP3A4 induction in primary cultures of human hepatocytes.	ochratoxin A	19-31	nuclear receptor subfamily 1 group I member 2	Homo sapiens	64-67
26341324-0	2015	A food contaminant ochratoxin A suppresses pregnane X receptor (PXR)-mediated CYP3A4 induction in primary cultures of human hepatocytes.	ochratoxin A	19-31	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	78-84
30090334-0	2016	miR-122 plays an important role in ochratoxin A-induced hepatocyte apoptosis in vitro and in vivo.	ochratoxin A	35-47	microRNA 122	Homo sapiens	0-7
25694087-0	2015	Effects of Chronic Ochratoxin A Exposure on p53 Heterozygous and p53 Homozygous Mice.	ochratoxin A	19-31	transformation related protein 53, pseudogene	Mus musculus	44-47
25694087-0	2015	Effects of Chronic Ochratoxin A Exposure on p53 Heterozygous and p53 Homozygous Mice.	ochratoxin A	19-31	transformation related protein 53, pseudogene	Mus musculus	65-68
25636497-0	2015	Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice.	ochratoxin A	36-48	transformation related protein 53, pseudogene	Mus musculus	8-11
25636497-1	2015	Carcinogenic doses of ochratoxin A (OTA) cause increases of mutant frequencies (MFs) of the red/gam gene (Spi(-)) in the kidneys of p53-deficient gpt delta mice, but not in p53-proficient mice.	ochratoxin A	22-34	transformation related protein 53, pseudogene	Mus musculus	132-135
26514935-0	2015	MiR-122 partly mediates the ochratoxin A-induced GC-2 cell apoptosis.	ochratoxin A	28-40	membrane associated ring-CH-type finger 8	Homo sapiens	0-3
25002221-0	2015	Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells.	ochratoxin A	0-12	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	32-37
25002221-0	2015	Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells.	ochratoxin A	0-12	AKT serine/threonine kinase 1	Homo sapiens	43-46
25002221-0	2015	Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells.	ochratoxin A	0-12	mitogen-activated protein kinase 3	Homo sapiens	56-63
25111321-0	2014	Is increased susceptibility to Balkan endemic nephropathy in carriers of common GSTA1 (*A/*B) polymorphism linked with the catalytic role of GSTA1 in ochratoxin a biotransformation?	ochratoxin A	150-162	glutathione S-transferase alpha 1	Homo sapiens	80-85
25127400-0	2014	Use of cloneable peptide-MBP fusion protein as a mimetic coating antigen in the standardized immunoassay for mycotoxin ochratoxin A.	ochratoxin A	119-131	myelin basic protein	Homo sapiens	25-28
24930758-0	2014	Disturbed Hsp70 and Hsp27 expression and thiol redox status in porcine kidney PK15 cells provoked by individual and combined ochratoxin A and citrinin treatments.	ochratoxin A	125-137	heat shock 70 kDa protein 6	Sus scrofa	10-15
24930758-0	2014	Disturbed Hsp70 and Hsp27 expression and thiol redox status in porcine kidney PK15 cells provoked by individual and combined ochratoxin A and citrinin treatments.	ochratoxin A	125-137	heat shock protein beta-1	Sus scrofa	20-25
25279298-7	2014	Conversely, cytotoxicity was valued as zearalenone > deoxynivalenol > ochratoxin A in relation to the acetylcholinesterase enzymatic activity.	ochratoxin A	76-88	acetylcholinesterase (Cartwright blood group)	Gallus gallus	108-128
25111321-0	2014	Is increased susceptibility to Balkan endemic nephropathy in carriers of common GSTA1 (*A/*B) polymorphism linked with the catalytic role of GSTA1 in ochratoxin a biotransformation?	ochratoxin A	150-162	glutathione S-transferase alpha 1	Homo sapiens	141-146
24448208-0	2014	A review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity.	ochratoxin A	30-42	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
24633129-5	2014	In addition, hBD-3 elevated the transepithelial electrical resistance and reduced the paracellular permeability of keratinocyte layers, and this effect was reversed by the claudin inhibitor ochratoxin A, CCR6 antibody, and CCR6 small interfering RNA.	ochratoxin A	190-202	defensin beta 103B	Homo sapiens	13-18
24755393-0	2014	Central role of Nix in the autophagic response to ochratoxin A.	ochratoxin A	50-62	BCL2 interacting protein 3 like	Homo sapiens	16-19
24565693-0	2014	Protective role of the mitochondrial Lon protease 1 in ochratoxin A-induced cytotoxicity in HEK293 cells.	ochratoxin A	55-67	lon peptidase 1, mitochondrial	Homo sapiens	37-51
24636559-7	2014	In particular, the inclusion of an IAC step allowed achieving LOQs as low as 0.05 and 0.25mug/kg in cereals for aflatoxins and ochratoxin A, respectively.	ochratoxin A	127-139	TARBP2 subunit of RISC loading complex	Homo sapiens	62-66
24448208-1	2014	Several studies have demonstrated that ochratoxin A (OTA) inhibits the nuclear factor, erythroid 2-like 2 (Nrf2) oxidative stress response pathway.	ochratoxin A	39-51	NFE2 like bZIP transcription factor 2	Homo sapiens	71-105
24448208-1	2014	Several studies have demonstrated that ochratoxin A (OTA) inhibits the nuclear factor, erythroid 2-like 2 (Nrf2) oxidative stress response pathway.	ochratoxin A	39-51	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
24862212-4	2014	Furthermore, LL-37 elevated the transepithelial electrical resistance while reducing the paracellular permeability of keratinocyte layers, and this activity was weakened by the claudin inhibitor ochratoxin A.	ochratoxin A	195-207	cathelicidin antimicrobial peptide	Homo sapiens	13-18
24862212-6	2014	In addition, LL-37 enhanced the expression of differentiation markers under the control of ochratoxin A, suggesting an association between LL-37-induced TJ function and keratinocyte differentiation.	ochratoxin A	91-103	cathelicidin antimicrobial peptide	Homo sapiens	13-18
24862212-6	2014	In addition, LL-37 enhanced the expression of differentiation markers under the control of ochratoxin A, suggesting an association between LL-37-induced TJ function and keratinocyte differentiation.	ochratoxin A	91-103	cathelicidin antimicrobial peptide	Homo sapiens	139-144
24243707-0	2014	Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats.	ochratoxin A	0-12	glutamic--pyruvic transaminase	Rattus norvegicus	110-113
23466516-0	2013	Potential endocrine disrupting effect of ochratoxin A on human placental 3beta-hydroxysteroid dehydrogenase/isomerase in JEG-3 cells at levels relevant to human exposure.	ochratoxin A	41-53	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	73-117
23515941-0	2013	Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro.	ochratoxin A	36-48	ATM serine/threonine kinase	Homo sapiens	75-104
23515941-0	2013	Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro.	ochratoxin A	36-48	ATM serine/threonine kinase	Homo sapiens	106-109
22987806-0	2013	Fluorescence spectroscopic investigation of competitive interactions between ochratoxin A and 13 drug molecules for binding to human serum albumin.	ochratoxin A	77-89	albumin	Homo sapiens	133-146
21554934-0	2011	Aristolochic acid I and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells--the involvement of SP-1 and HIFs transcription factors.	ochratoxin A	24-36	vascular endothelial growth factor A	Sus scrofa	61-65
23172667-0	2013	Ochratoxin A-induced cell proliferation and tumor promotion in mouse skin by activating the expression of cyclin-D1 and cyclooxygenase-2 through nuclear factor-kappa B and activator protein-1.	ochratoxin A	0-12	cyclin D1	Mus musculus	106-115
23281030-0	2013	Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells.	ochratoxin A	90-102	heme oxygenase 1	Homo sapiens	70-86
23281030-2	2013	We investigated the cross-talk between microRNAs, nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) in ochratoxin A-mediated effects.	ochratoxin A	124-136	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
23281030-2	2013	We investigated the cross-talk between microRNAs, nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) in ochratoxin A-mediated effects.	ochratoxin A	124-136	heme oxygenase 1	Homo sapiens	97-113
23281030-2	2013	We investigated the cross-talk between microRNAs, nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) in ochratoxin A-mediated effects.	ochratoxin A	124-136	heme oxygenase 1	Homo sapiens	115-119
22045303-3	2012	The aim of this study was to evaluate the effects of one of the most widespread mycotoxin, ochratoxin A (OTA), on the release of pro-inflammatory cytokines such as interleukin-(IL)-6 and the CXC-chemokine IL-8 from nasal epithelial cell cultures (NEC) of subjects with and without ECRS.	ochratoxin A	91-103	interleukin 6	Homo sapiens	164-182
22045303-3	2012	The aim of this study was to evaluate the effects of one of the most widespread mycotoxin, ochratoxin A (OTA), on the release of pro-inflammatory cytokines such as interleukin-(IL)-6 and the CXC-chemokine IL-8 from nasal epithelial cell cultures (NEC) of subjects with and without ECRS.	ochratoxin A	91-103	C-X-C motif chemokine ligand 8	Homo sapiens	205-209
21834667-0	2012	Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors.	ochratoxin A	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	21-27
21834667-0	2012	Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors.	ochratoxin A	0-12	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	53-59
23095759-12	2012	RESULTS: A 48 h exposure to ochratoxin A was followed by significant increase of Fluo3-fluorescencei (>= 2.5 microM), increase of ceramide abundance (10 microM), decrease of forward scatter (>= 5 microM) and increase of annexin-V-binding (>= 2.5 microM).	ochratoxin A	28-40	annexin A5	Homo sapiens	226-235
21622941-0	2011	Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A.	ochratoxin A	96-108	glutamic--pyruvic transaminase	Rattus norvegicus	52-55
21763279-0	2011	p53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation.	ochratoxin A	24-36	tumor protein p53	Homo sapiens	0-3
21763279-0	2011	p53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation.	ochratoxin A	24-36	mitogen-activated protein kinase 8	Homo sapiens	118-121
21763279-4	2011	In the present study, we find that p53 activation exerts pro-survival function to inhibit apoptosis induction in MARC-145, Vero monkey kidney cells and HEK293 human kidney cells in response to ochratoxin A treatment.	ochratoxin A	193-205	tumor protein p53	Homo sapiens	35-38
23793075-7	2013	SPR analysis confirmed that the peptides bind to ochratoxin A, with calculated K(D) values of ~15.7 muM (13-mer) and ~11.8 muM (octamer).	ochratoxin A	49-61	latexin	Homo sapiens	100-103
23793075-7	2013	SPR analysis confirmed that the peptides bind to ochratoxin A, with calculated K(D) values of ~15.7 muM (13-mer) and ~11.8 muM (octamer).	ochratoxin A	49-61	latexin	Homo sapiens	123-126
23261758-0	2013	Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice.	ochratoxin A	27-39	transformation related protein 53, pseudogene	Mus musculus	11-14
23261758-0	2013	Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice.	ochratoxin A	27-39	transformation related protein 53, pseudogene	Mus musculus	64-67
23261758-0	2013	Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice.	ochratoxin A	27-39	glutamic pyruvic transaminase, soluble	Mus musculus	78-81
22634515-0	2012	Flavonoid aglycones can compete with Ochratoxin A for human serum albumin: a new possible mode of action.	ochratoxin A	37-49	albumin	Homo sapiens	60-73
22778029-0	2012	The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-alpha expression in human primary proximal tubule cells.	ochratoxin A	37-49	tumor necrosis factor	Homo sapiens	59-125
22230261-0	2012	ERK and p38 MAPK signaling pathways are involved in ochratoxin A-induced G2 phase arrest in human gastric epithelium cells.	ochratoxin A	52-64	mitogen-activated protein kinase 1	Homo sapiens	0-3
22230261-0	2012	ERK and p38 MAPK signaling pathways are involved in ochratoxin A-induced G2 phase arrest in human gastric epithelium cells.	ochratoxin A	52-64	mitogen-activated protein kinase 14	Homo sapiens	8-11
22230261-0	2012	ERK and p38 MAPK signaling pathways are involved in ochratoxin A-induced G2 phase arrest in human gastric epithelium cells.	ochratoxin A	52-64	mitogen-activated protein kinase 1	Homo sapiens	12-16
20549612-0	2011	Molecular events involved in ochratoxin A induced mitochondrial pathway of apoptosis, modulation by Bcl-2 family members.	ochratoxin A	29-41	BCL2 apoptosis regulator	Homo sapiens	100-105
20590410-0	2011	Ochratoxin A inhibits adipogenesis through the extracellular signal-related kinases-peroxisome proliferator-activated receptor-gamma pathway in human adipose tissue-derived mesenchymal stem cells.	ochratoxin A	0-12	peroxisome proliferator activated receptor gamma	Homo sapiens	84-132
21160495-4	2011	Incubation with ochratoxin A decreased the expression of claudin-4, an integral membrane protein of TJs, and the diffusion of paracellular tracer was no longer prevented at the TJs.	ochratoxin A	16-28	claudin 4	Homo sapiens	57-66
21204536-1	2011	A direct competitive chemiluminescent enzyme-linked immunosorbent assay (CL-ELISA) for the determination of ochratoxin A (OTA) was developed using soybean peroxidase (SbP) in combination with 3-(10"-phenothiazinyl)propane-1-sulfonate (SPTZ) and 4-morpholinopyridine (MORPH) as a detection system.	ochratoxin A	108-120	peroxidase	Glycine max	155-165
20558201-0	2010	The food-associated fungal neurotoxin ochratoxin A inhibits the absorption of glutamate by astrocytes through a decrease in cell surface expression of the excitatory amino-acid transporters GLAST and GLT-1.	ochratoxin A	38-50	solute carrier family 1 member 3	Rattus norvegicus	190-195
21778665-0	2011	A novel human organic anion transporter NPT4 mediates the transport of ochratoxin A.	ochratoxin A	71-83	solute carrier family 17 member 3	Homo sapiens	40-44
21778665-1	2011	In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system.	ochratoxin A	77-89	orthodenticle homeobox 2 S homeolog	Xenopus laevis	91-95
21778665-1	2011	In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system.	ochratoxin A	77-89	solute carrier family 17 member 3	Homo sapiens	140-145
20558201-0	2010	The food-associated fungal neurotoxin ochratoxin A inhibits the absorption of glutamate by astrocytes through a decrease in cell surface expression of the excitatory amino-acid transporters GLAST and GLT-1.	ochratoxin A	38-50	solute carrier family 1 member 2	Rattus norvegicus	200-205
22069638-1	2010	The release of tumor necrosis factor alpha (TNF-alpha) by ochratoxin A (OTA) was studied in various macrophage and non-macrophage cell lines and compared with E. coli lipopolysaccharide (LPS) as a standard TNF-alpha release agent.	ochratoxin A	58-70	tumor necrosis factor	Mus musculus	44-53
19833843-2	2010	In vitro transport studies using human embryonic kidney 293 cells expressing mouse Oatp1a4 identified the following compounds as Oatp1a4 substrates: pitavastatin (K(m) = 8.3 microM), rosuvastatin (K(m) = 12 microM), pravastatin, taurocholate (K(m) = 40 microM), digoxin, ochratoxin A, and [d-penicillamine(2,5)]-enkephalin.	ochratoxin A	271-283	solute carrier organic anion transporter family, member 1a4	Mus musculus	129-136
20103152-14	2010	Finally, based on the results, it was concluded that the combination of C-18 cartridges with conventional particle packed columns and HPLC-FLD is the most appropriate alternative for Ochratoxin A analysis in wine.	ochratoxin A	183-195	Bardet-Biedl syndrome 9	Homo sapiens	72-76
19833843-5	2010	The blood-to-brain transport of pitavastatin, rosuvastatin, taurocholate, and ochratoxin A, determined by in situ brain perfusion, was significantly lower in Oatp1a4(-/-) mice than in wild-type mice, whereas transport of pravastatin and [D-penicillamine(2,5)]-enkephalin was unchanged.	ochratoxin A	78-90	solute carrier organic anion transporter family, member 1a4	Mus musculus	158-165
20036863-0	2010	Ochratoxin A induces craniofacial malformation in mice acting on Dlx5 gene expression.	ochratoxin A	0-12	distal-less homeobox 5	Mus musculus	65-69
19538982-0	2009	Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex.	ochratoxin A	13-25	solute carrier family 22 member 6	Rattus norvegicus	90-94
18547363-7	2009	Ochratoxin A significantly decreased gamma-glutamylcysteinyl synthetase and glutathione-S-transferase mRNA levels in LLC-PK1 cells.	ochratoxin A	0-12	microsomal glutathione S-transferase 1	Sus scrofa	76-101
19538982-0	2009	Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex.	ochratoxin A	13-25	solute carrier family 22 (organic anion transporter), member 7, pseudogene 1	Rattus norvegicus	96-100
19538982-0	2009	Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex.	ochratoxin A	13-25	solute carrier family 22 member 8	Rattus norvegicus	102-106
19538982-0	2009	Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex.	ochratoxin A	13-25	solute carrier family 22, member 24	Rattus norvegicus	111-115
18441515-2	2008	When expressed in Xenopus oocytes, UST1r mediated uptake of ochratoxin A (OTA; K(m) = 1.0 microM) and sulfate conjugates of steroids, such as estrone-3-sulfate (ES; K(m) = 3.1 microM) and dehydroepiandrosterone sulfate (DHEAS; K(m) = 2.1 microM) in a sodium-independent manner.	ochratoxin A	60-72	solute carrier family 22, member 25	Rattus norvegicus	35-40
18485430-0	2008	Could ochratoxin A in food commodities be the cause of chronic kidney disease in Sri Lanka?	ochratoxin A	6-18	sorcin	Homo sapiens	81-84
18289624-0	2008	Ochratoxin A inhibits the production of tissue factor and plasminogen activator inhibitor-2 by human blood mononuclear cells: another potential mechanism of immune-suppression.	ochratoxin A	0-12	coagulation factor III, tissue factor	Homo sapiens	40-53
18547704-0	2008	Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells.	ochratoxin A	10-22	microsomal glutathione S-transferase 1	Sus scrofa	89-114
18308354-7	2008	We found that deoxynivalenol, ochratoxin A and patulin all potentiated the effect of IL-1beta on IL-8 secretion (ranging from 35% to 138% increase) and increased the transepithelial passage of commensal bacteria (ranging from 12- to 1544-fold increase).	ochratoxin A	30-42	interleukin 1 beta	Homo sapiens	85-93
18308354-7	2008	We found that deoxynivalenol, ochratoxin A and patulin all potentiated the effect of IL-1beta on IL-8 secretion (ranging from 35% to 138% increase) and increased the transepithelial passage of commensal bacteria (ranging from 12- to 1544-fold increase).	ochratoxin A	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
17562227-1	2007	The aim of the present study was to verify whether the oral administration of cyanidin 3-O-beta-D-glucoside (C3G) might counteract damage induced by chronic exposure (28 d) to ochratoxin A (OTA) in rats and if its effect may be mediated by haeme oxygenase-1 (HO-1).	ochratoxin A	176-188	Rap guanine nucleotide exchange factor 1	Rattus norvegicus	109-112
16150593-4	2005	When mOAT5 was expressed in Xenopus oocytes, mOAT5 transported estrone sulfate, dehydroepiandrosterone sulfate and ochratoxin A.	ochratoxin A	115-127	solute carrier family 22 (organic anion transporter), member 19	Mus musculus	5-10
16857307-1	2006	We characterized the overall early effect of chronic ochratoxin A (OTA) treatment on rat liver, analyzing different aspects related to: (i) fibrosis, by measuring collagen content and turnover, and alpha-smooth muscle actin (alphaSMA); (ii) oxidative stress and stress response, by analyzing protein carbonylation, superoxide dismutase (SOD) and heat shock protein (HSP70) gene expression; (iii) the possible tumor promoter effect, evaluating cadherin and connexin (CX) mRNA levels.	ochratoxin A	53-65	actin gamma 2, smooth muscle	Rattus norvegicus	198-223
16857307-1	2006	We characterized the overall early effect of chronic ochratoxin A (OTA) treatment on rat liver, analyzing different aspects related to: (i) fibrosis, by measuring collagen content and turnover, and alpha-smooth muscle actin (alphaSMA); (ii) oxidative stress and stress response, by analyzing protein carbonylation, superoxide dismutase (SOD) and heat shock protein (HSP70) gene expression; (iii) the possible tumor promoter effect, evaluating cadherin and connexin (CX) mRNA levels.	ochratoxin A	53-65	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	346-371
17651772-0	2007	MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma.	ochratoxin A	59-71	mitogen activated protein kinase 3	Rattus norvegicus	5-8
17359339-6	2007	We also found that the addition of ochratoxin A weakened the permeability barrier and the expression of claudin-4.	ochratoxin A	35-47	claudin 4	Homo sapiens	104-113
16643956-0	2006	Expression of COX-2 and hsp72 in peritoneal macrophages after an acute ochratoxin A treatment in mice.	ochratoxin A	71-83	cytochrome c oxidase II, mitochondrial	Mus musculus	14-19
16643956-0	2006	Expression of COX-2 and hsp72 in peritoneal macrophages after an acute ochratoxin A treatment in mice.	ochratoxin A	71-83	heat shock protein 1A	Mus musculus	24-29
16478971-6	2006	The organic anions ochratoxin A, salicylate, penicillin G, p-aminohippurate, and urate inhibited mOat6-mediated accumulation to varying degrees.	ochratoxin A	19-31	solute carrier family 22 (organic anion transporter), member 20	Mus musculus	97-102
16150593-4	2005	When mOAT5 was expressed in Xenopus oocytes, mOAT5 transported estrone sulfate, dehydroepiandrosterone sulfate and ochratoxin A.	ochratoxin A	115-127	solute carrier family 22 (organic anion transporter), member 19	Mus musculus	45-50
16705817-9	2005	Our results confirm that ochratoxin A induces chronic tubular nephropathy in humans and mainly point at those having the HLA haplotype A3, B27/35, DR7 to be more sensitive to the disease for quantitatively similar or lower exposure.	ochratoxin A	25-37	melanocortin 2 receptor accessory protein	Homo sapiens	139-145
16079298-1	2005	A novel member of the organic anion transporter (OAT) family, Oat5 (Slc22a19), has been reported to transport a naturally occurring mycotoxin, ochratoxin A (OTA).	ochratoxin A	143-155	solute carrier family 22, member 24	Rattus norvegicus	62-66
16079298-1	2005	A novel member of the organic anion transporter (OAT) family, Oat5 (Slc22a19), has been reported to transport a naturally occurring mycotoxin, ochratoxin A (OTA).	ochratoxin A	143-155	solute carrier family 22, member 24	Rattus norvegicus	68-76
23605335-0	2005	In vitro induction of tumor necrosis factor-alpha by ochratoxin A (OTA) from rat liver: role of Kupffer cells.	ochratoxin A	53-65	tumor necrosis factor	Rattus norvegicus	22-49
23605335-1	2005	Tumor necrosis factor-alpha (TNF-alpha) is released from blood-free perfused rat liver by the fungal metabolite ochratoxin A.	ochratoxin A	112-124	tumor necrosis factor	Rattus norvegicus	0-27
23605335-1	2005	Tumor necrosis factor-alpha (TNF-alpha) is released from blood-free perfused rat liver by the fungal metabolite ochratoxin A.	ochratoxin A	112-124	tumor necrosis factor	Rattus norvegicus	29-38
23605336-6	2005	The results show that citrinin had an antagonistic effect on ochratoxin A induced caspase 3-activation in concentrations of 2.5 and 5 mumol/l.	ochratoxin A	61-73	caspase 3	Homo sapiens	82-91
15626719-0	2005	Proximal tubular toxicity of ochratoxin A is amplified by simultaneous inhibition of the extracellular signal-regulated kinases 1/2.	ochratoxin A	29-41	mitogen-activated protein kinase 1	Homo sapiens	89-131
14752240-0	2004	Increased renal fibrosis and expression of renal phosphatidylinositol 4-kinase-beta and phospholipase C(gamma1) proteins in piglets exposed to ochratoxin-A.	ochratoxin A	143-155	phosphatidylinositol 4-kinase beta	Sus scrofa	49-83
15695019-0	2005	Interference of arachidonic acid and its metabolites with TNF-alpha release by ochratoxin A from rat liver.	ochratoxin A	79-91	tumor necrosis factor	Rattus norvegicus	58-67
15695019-1	2005	We investigated the role of arachidonic acid and its metabolites on the ochratoxin A (OTA) provoked release of proinflammatory and apoptotic cytokine TNF-alpha from blood-free perfused rat liver.	ochratoxin A	72-84	tumor necrosis factor	Rattus norvegicus	150-159
15068970-7	2004	Murine Oat5-expressing Xenopus laevis oocytes supported increased accumulation of the mycotoxin ochratoxin A, compared with water-injected control oocytes.	ochratoxin A	96-108	solute carrier family 22 (organic anion transporter), member 19	Mus musculus	7-11
15068970-9	2004	Transport of ochratoxin A by murine Oat5 was saturable, with an estimated K(m) of 2.0 +/- 0.45 microM.	ochratoxin A	13-25	solute carrier family 22 (organic anion transporter), member 19	Mus musculus	36-40
15056805-0	2004	Ochratoxin A induces apoptosis in human lymphocytes through down regulation of Bcl-xL.	ochratoxin A	0-12	BCL2 like 1	Homo sapiens	79-85
14713565-0	2004	Inhibitory effects of ochratoxin A on nerve growth factor-induced neurite extension through downregulation of p38 MAP kinase and AP-1 activation in cultured pheochromocytoma cells.	ochratoxin A	22-34	nerve growth factor	Rattus norvegicus	38-57
14713565-0	2004	Inhibitory effects of ochratoxin A on nerve growth factor-induced neurite extension through downregulation of p38 MAP kinase and AP-1 activation in cultured pheochromocytoma cells.	ochratoxin A	22-34	mitogen activated protein kinase 14	Rattus norvegicus	110-113
14752240-0	2004	Increased renal fibrosis and expression of renal phosphatidylinositol 4-kinase-beta and phospholipase C(gamma1) proteins in piglets exposed to ochratoxin-A.	ochratoxin A	143-155	phospholipase C gamma 1	Sus scrofa	88-110
12676495-0	2003	Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2).	ochratoxin A	15-27	ATP binding cassette subfamily C member 3	Homo sapiens	90-129
12849727-1	2003	The modulations of complement-regulating surface proteins on a human embryonic and a renal carcinoma cell line are described regarding the effects of ochratoxin A and some of its metabolites on the surface markers CD46, CD55 and CD59.	ochratoxin A	150-162	CD46 molecule	Homo sapiens	214-218
12849727-1	2003	The modulations of complement-regulating surface proteins on a human embryonic and a renal carcinoma cell line are described regarding the effects of ochratoxin A and some of its metabolites on the surface markers CD46, CD55 and CD59.	ochratoxin A	150-162	CD59 molecule (CD59 blood group)	Homo sapiens	229-233
23604762-0	2003	Inhibition of the mitogen activated protein kinase ERK1/2 amplifies ochratoxin A toxicity in the proximal tubule of the kidney.	ochratoxin A	68-80	mitogen activated protein kinase 3	Rattus norvegicus	51-57
12676495-0	2003	Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2).	ochratoxin A	15-27	ATP binding cassette subfamily C member 2	Homo sapiens	131-135
12605306-8	2003	OAT1 translocated, e.g., anti-inflammatory drugs, antiviral drugs, beta-lactam antibiotics, loop diuretics, ochratoxin A, and p-aminohippurate.	ochratoxin A	108-120	solute carrier family 22 member 6	Homo sapiens	0-4
12505377-0	2003	Effects of the mycotoxin ochratoxin A and some of its metabolites on the human cell line THP-1.	ochratoxin A	25-37	GLI family zinc finger 2	Homo sapiens	89-94
12505377-1	2003	The immunomodulatory effects of ochratoxin A (OTA) and some of its metabolites on the human monocyte/macrophage line THP-1 are described.	ochratoxin A	32-44	GLI family zinc finger 2	Homo sapiens	117-122
12605306-10	2003	Human, rat and mouse OAT2 transported selected anti-inflammatory and antiviral drugs, methotrexate, ochratoxin A, and, with high affinities, prostaglandins E(2) and F(2alpha).	ochratoxin A	100-112	solute carrier family 22 (organic anion transporter), member 7	Mus musculus	21-25
12385724-0	2002	Interaction of ochratoxin A with human serum albumin.	ochratoxin A	15-27	albumin	Homo sapiens	39-52
11936221-0	2002	Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells.	ochratoxin A	81-93	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	21-69
12065749-6	2002	mOAT2-expressing oocytes also mediated the uptake of alpha-ketoglutarate, glutarate, prostaglandin E2, p-aminohippuric acid, methotrexate, ochratoxin A, valproate, and allopurinol.	ochratoxin A	139-151	solute carrier family 22 (organic anion transporter), member 7	Mus musculus	0-5
12063169-0	2002	Role of human organic anion transporter 4 in the transport of ochratoxin A.	ochratoxin A	62-74	solute carrier family 22 member 11	Homo sapiens	14-41
12029385-0	2002	Expression of Hsp70 in kidney cells exposed to ochratoxin A.	ochratoxin A	47-59	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	14-19
11998373-0	2002	[In vitro studies into the influence of ochratoxin A on the production of tumor necrosis factor alpha by the human monocytic cell line THP-1].	ochratoxin A	40-52	tumor necrosis factor	Homo sapiens	74-101
11998373-0	2002	[In vitro studies into the influence of ochratoxin A on the production of tumor necrosis factor alpha by the human monocytic cell line THP-1].	ochratoxin A	40-52	GLI family zinc finger 2	Homo sapiens	135-140
11669456-1	2001	The purpose of this study was to investigate the characteristics of ochratoxin A (OTA) transport by multispecific human organic anion transporters (hOAT1 and hOAT3, respectively) using the second segment of proximal tubule (S2) cells from mice stably expressing hOAT1 and hOAT3 (S2 hOAT1 and S2 hOAT3).	ochratoxin A	68-80	solute carrier family 22 member 6	Homo sapiens	148-153
11829670-6	2002	The relative cross-reactivity with aflatoxins (AF) and ochratoxin A, assessed as the amount of AFM1 necessary to cause 50% inhibition of binding, was 5% for AFB1 and much less for AFB2, AFG1, and AFG2; there was no reaction with ochratoxin A.	ochratoxin A	55-67	AFG1 like ATPase	Homo sapiens	186-190
11829670-6	2002	The relative cross-reactivity with aflatoxins (AF) and ochratoxin A, assessed as the amount of AFM1 necessary to cause 50% inhibition of binding, was 5% for AFB1 and much less for AFB2, AFG1, and AFG2; there was no reaction with ochratoxin A.	ochratoxin A	55-67	spermatogenesis associated 5	Homo sapiens	196-200
11669456-1	2001	The purpose of this study was to investigate the characteristics of ochratoxin A (OTA) transport by multispecific human organic anion transporters (hOAT1 and hOAT3, respectively) using the second segment of proximal tubule (S2) cells from mice stably expressing hOAT1 and hOAT3 (S2 hOAT1 and S2 hOAT3).	ochratoxin A	68-80	solute carrier family 22 member 8	Homo sapiens	158-163
11669456-1	2001	The purpose of this study was to investigate the characteristics of ochratoxin A (OTA) transport by multispecific human organic anion transporters (hOAT1 and hOAT3, respectively) using the second segment of proximal tubule (S2) cells from mice stably expressing hOAT1 and hOAT3 (S2 hOAT1 and S2 hOAT3).	ochratoxin A	68-80	solute carrier family 22 member 6	Homo sapiens	262-267
11669456-1	2001	The purpose of this study was to investigate the characteristics of ochratoxin A (OTA) transport by multispecific human organic anion transporters (hOAT1 and hOAT3, respectively) using the second segment of proximal tubule (S2) cells from mice stably expressing hOAT1 and hOAT3 (S2 hOAT1 and S2 hOAT3).	ochratoxin A	68-80	solute carrier family 22 member 8	Homo sapiens	272-277
11669456-1	2001	The purpose of this study was to investigate the characteristics of ochratoxin A (OTA) transport by multispecific human organic anion transporters (hOAT1 and hOAT3, respectively) using the second segment of proximal tubule (S2) cells from mice stably expressing hOAT1 and hOAT3 (S2 hOAT1 and S2 hOAT3).	ochratoxin A	68-80	solute carrier family 22 member 6	Homo sapiens	262-267
11669456-1	2001	The purpose of this study was to investigate the characteristics of ochratoxin A (OTA) transport by multispecific human organic anion transporters (hOAT1 and hOAT3, respectively) using the second segment of proximal tubule (S2) cells from mice stably expressing hOAT1 and hOAT3 (S2 hOAT1 and S2 hOAT3).	ochratoxin A	68-80	solute carrier family 22 member 8	Homo sapiens	272-277
11331016-6	2001	The uptakes of p-aminohippurate (PAH), estrone sulfate, and ochratoxin A were approximately 10-, approximately 48-, and approximately 32-fold enhanced in oocytes expressing rOAT3 and were only approximately 2-, approximately 6-, and approximately 5-fold enhanced for R454D.	ochratoxin A	60-72	solute carrier family 22 member 8	Rattus norvegicus	173-178
11306713-6	2001	hOAT3 also mediated the transport of dehydroepiandrosterone sulfate, ochratoxin A, PGE(2), estradiol glucuronide, taurocholate, glutarate, cAMP and uric acid.	ochratoxin A	69-81	solute carrier family 22 member 8	Homo sapiens	0-5
11189750-4	1999	Of the nine CYP450s introduced CYP1A2 was most effective, rendering the cells 540 times more sensitive than the control cells to aflatoxin B1, 28 times more sensitive to aflatoxin G1 and 8-fold more sensitive to ochratoxin A.	ochratoxin A	212-224	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	31-37
10964764-0	2000	Studies of ochratoxin A-induced inhibition of phenylalanine hydroxylase and its reversal by phenylalanine.	ochratoxin A	11-23	phenylalanine hydroxylase	Homo sapiens	46-71
10964764-4	2000	We have examined the effects of low doses of ochratoxin A on the activity of phenylalanine hydroxylase in kidney and in liver of experimental animals.	ochratoxin A	45-57	phenylalanine hydroxylase	Homo sapiens	77-102
10964764-5	2000	Daily administration of ochratoxin A (50 microg/kg body wt, for 10 and 35 days, respectively) caused a significant reduction in the phenylalanine hydroxylase activity.	ochratoxin A	24-36	phenylalanine hydroxylase	Homo sapiens	132-157
10964764-9	2000	Simultaneous application of ochratoxin A with phenylalanine could reduce inhibition of phenylalanine hydroxylase, in particular in liver.	ochratoxin A	28-40	phenylalanine hydroxylase	Homo sapiens	87-112
23605529-0	2000	Ochratoxin A induced TNFalpha release from the isolated and blood- free perfused rat liver.	ochratoxin A	0-12	tumor necrosis factor	Rattus norvegicus	21-29
10760098-8	2000	The nephrotoxic mycotoxin ochratoxin A inhibited MRP2-mediated PAH transport with an IC50 value of 58 micromol/L.	ochratoxin A	26-38	ATP binding cassette subfamily C member 2	Homo sapiens	49-53
10760098-9	2000	Ochratoxin A was itself a substrate for MRP2.	ochratoxin A	0-12	ATP binding cassette subfamily C member 2	Homo sapiens	40-44
10660625-6	2000	OAT4 also mediated the transport of ochratoxin A.	ochratoxin A	36-48	solute carrier family 22 member 11	Homo sapiens	0-4
10224140-5	1999	When expressed in Xenopus laevis oocytes, OAT3 mediated the uptake of organic anions, such as p-aminohippurate (Km = 65 microM), ochratoxin A (Km = 0.74 microM), and estrone sulfate (Km = 2.3 microM) and a cationic compound, cimetidine.	ochratoxin A	129-141	solute carrier family 22 member 8	Rattus norvegicus	42-46
10336520-0	1999	Transport of ochratoxin A by renal multispecific organic anion transporter 1.	ochratoxin A	13-25	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	49-76
10336520-1	1999	In the present study, we investigated the transport of ochratoxin A (OTA) by kidney-specific organic anion transporter 1 (OAT1).	ochratoxin A	55-67	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	93-120
10336520-1	1999	In the present study, we investigated the transport of ochratoxin A (OTA) by kidney-specific organic anion transporter 1 (OAT1).	ochratoxin A	55-67	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	122-126
11178522-0	1998	[Ochratoxins: Molecular strategies for developing an antidote] Ochratoxin A (OcA) is a prominent member of a group of mycotoxins which display nephrotoxic, genotoxic, teratogenic, carcinogenic and immunosuppressive effects and which have also been linked to Balkan Endemic Nephropathy.	ochratoxin A	63-75	bone gamma carboxyglutamate protein	Mus musculus	77-80
10048753-0	1999	The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats.	ochratoxin A	32-44	alpha2u globulin	Rattus norvegicus	12-28
21781659-4	1996	The pivotal role of cytochrome P450 in the mutagenicity of ochratoxin A could be demonstrated in experiments with cell lines stably expressing the human cytochrome P450 enzymes.	ochratoxin A	59-71	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	20-35
8691508-6	1996	When EL-4 cells were exposed to 5 and 10 microgram/ml of ochratoxin A, IL-2 production was markedly increased while IL-5 production was significantly decreased.	ochratoxin A	57-69	epilepsy 4	Mus musculus	5-9
8691508-6	1996	When EL-4 cells were exposed to 5 and 10 microgram/ml of ochratoxin A, IL-2 production was markedly increased while IL-5 production was significantly decreased.	ochratoxin A	57-69	interleukin 2	Mus musculus	71-75
8691508-6	1996	When EL-4 cells were exposed to 5 and 10 microgram/ml of ochratoxin A, IL-2 production was markedly increased while IL-5 production was significantly decreased.	ochratoxin A	57-69	interleukin 5	Mus musculus	116-120
8691508-12	1996	In total, the EL-4 culture studies indicated that cyclopiazonic acid, ochratoxin A, zearalenone, and alpha-zearalenol could stimulate cytokine production whereas patulin and T-2 toxin were inhibitory.	ochratoxin A	70-82	epilepsy 4	Mus musculus	14-18
21781659-4	1996	The pivotal role of cytochrome P450 in the mutagenicity of ochratoxin A could be demonstrated in experiments with cell lines stably expressing the human cytochrome P450 enzymes.	ochratoxin A	59-71	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	153-168
21781659-5	1996	CYP1A1, 1A2, 2C10 and 3A4, which were able to activate the non-mutagenic ochratoxin A into mutagenic metabolites.	ochratoxin A	73-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
21781659-10	1996	The discrepancies found between microsomal and cellular metabolism leads to the conclusion that ochratoxin A mediated mutagenicity requires additional processing of cytochrome P450 derived metabolism.	ochratoxin A	96-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	165-180
8542584-0	1996	Development of human cytochrome P450-expressing cell lines: application in mutagenicity testing of ochratoxin A.	ochratoxin A	99-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-36
8542584-8	1996	We have demonstrated that the mutation frequency of ochratoxin A was increased dependent upon concentration in NIH/3T3 cell lines, stably expressing human CYP1A1, CYP1A2, CYP2C10, and CYP3A4.	ochratoxin A	52-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	155-161
8542584-8	1996	We have demonstrated that the mutation frequency of ochratoxin A was increased dependent upon concentration in NIH/3T3 cell lines, stably expressing human CYP1A1, CYP1A2, CYP2C10, and CYP3A4.	ochratoxin A	52-64	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	163-169
8542584-8	1996	We have demonstrated that the mutation frequency of ochratoxin A was increased dependent upon concentration in NIH/3T3 cell lines, stably expressing human CYP1A1, CYP1A2, CYP2C10, and CYP3A4.	ochratoxin A	52-64	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	171-178
8542584-8	1996	We have demonstrated that the mutation frequency of ochratoxin A was increased dependent upon concentration in NIH/3T3 cell lines, stably expressing human CYP1A1, CYP1A2, CYP2C10, and CYP3A4.	ochratoxin A	52-64	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	184-190
8788211-9	1995	Activation marker studies showed that the effect of treatment with both of the toxins was more pronounced on the late markers CD25 and CD71, while CD69 had the advantage that significant effects could be detected as early as 6 h after ochratoxin A treatment.	ochratoxin A	235-247	CD69 molecule	Homo sapiens	147-151
8788211-12	1995	A stimulating effect was found in cell cultures exposed to the lowest concentration of ochratoxin A on CD69 and CD25 expression.	ochratoxin A	87-99	CD69 molecule	Homo sapiens	103-107
8788211-12	1995	A stimulating effect was found in cell cultures exposed to the lowest concentration of ochratoxin A on CD69 and CD25 expression.	ochratoxin A	87-99	interleukin 2 receptor subunit alpha	Homo sapiens	112-116
8197587-0	1994	Effect of superoxide dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats.	ochratoxin A	108-120	catalase	Rattus norvegicus	35-43
7655625-0	1995	Determination of ochratoxin A at the ppt level in human blood, serum, milk and some foodstuffs by high-performance liquid chromatography with enhanced fluorescence detection and immunoaffinity column cleanup: methodology and Swiss data.	ochratoxin A	17-29	tachykinin precursor 1	Homo sapiens	37-40
8197587-10	1994	SOD and catalase prevented most of the nephrotoxic effects induced by ochratoxin A, observed as enzymuria, proteinuria, creatinemia and increased urinary excretion of OTA.	ochratoxin A	70-82	catalase	Rattus norvegicus	8-16
1853365-0	1991	Characterization of pig liver purified cytochrome P-450 isoenzymes for ochratoxin A metabolism studies.	ochratoxin A	71-83	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	39-55
8384007-3	1993	In the present investigation, we demonstrated the presence of OXT binding sites in porcine luteal tissue using a radioiodinated OXT antagonist, [1-(beta mercapto-beta,beta-cyclopentamethylene propionic acid),2-(ortho-methyl)-Tyr2-Thr4-Orn8-Tyr-NH2] vasotocin (OTA), as ligand.	ochratoxin A	260-263	oxytocin/neurophysin I prepropeptide	Homo sapiens	62-65
1770504-7	1991	Taken together, these results provide evidence for the stimulatory role of cytochrome P-450 in ochratoxin A-induced lipid peroxidation in a reconstituted system and strongly implicate its role in microsomal and in vivo ochratoxin A-induced lipid peroxidation.	ochratoxin A	95-107	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	75-91
1770504-7	1991	Taken together, these results provide evidence for the stimulatory role of cytochrome P-450 in ochratoxin A-induced lipid peroxidation in a reconstituted system and strongly implicate its role in microsomal and in vivo ochratoxin A-induced lipid peroxidation.	ochratoxin A	219-231	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	75-91
1808830-1	1991	Ochratoxin A was fed at 0.5 ppm to Lohmann-type chicks from 7 d of age for 4 w. Body weights and efficiency of feed utilization were depressed and the activity of serum SDH and GDH and the concentration of uric acid were significantly increased.	ochratoxin A	0-12	serine dehydratase	Homo sapiens	169-172
1808830-1	1991	Ochratoxin A was fed at 0.5 ppm to Lohmann-type chicks from 7 d of age for 4 w. Body weights and efficiency of feed utilization were depressed and the activity of serum SDH and GDH and the concentration of uric acid were significantly increased.	ochratoxin A	0-12	glutamate dehydrogenase 1	Homo sapiens	177-180
1770504-0	1991	Role of cytochrome P-450 in ochratoxin A-stimulated lipid peroxidation.	ochratoxin A	28-40	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	8-24
1770504-1	1991	The role of cytochrome P-450 in the stimulation of lipid peroxidation by the nephrotoxic mycotoxin ochratoxin A has been investigated.	ochratoxin A	99-111	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	12-28
1770504-2	1991	Ochratoxin A was previously shown to markedly stimulate lipid peroxidation in a reconstituted system consisting of phospholipid vesicles, NADPH-cytochrome P-450 reductase, Fe3+, ethylenediaminetetraacetic acid (EDTA), and reduced nicotinamide adenine dinucleotide phosphate (NADPH).	ochratoxin A	0-12	cytochrome p450 oxidoreductase	Rattus norvegicus	138-170
1820358-1	1991	A derivative of ochratoxin A was linked to bovine serum albumin in such a way that the carboxylic group of the toxin was left free.	ochratoxin A	16-28	albumin	Homo sapiens	50-63
34896195-0	2022	Corrigendum to "Ochratoxin A exposure decreased sperm motility via the AMPK and PTEN signaling pathways" (Toxicology and Applied Pharmacology 271 (2018) 49-57).	ochratoxin A	16-28	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	71-75
2171659-1	1990	The Fe3+ complex of ochratoxin A has been shown to produce hydroxyl radicals in the presence of NADPH and NADPH-cytochrome-P-450 reductase.	ochratoxin A	20-32	cytochrome p450 oxidoreductase	Homo sapiens	106-138
2167054-0	1990	The myocotoxin ochratoxin A is a substrate for phenylalanine hydroxylase in isolated rat hepatocytes and in vivo.	ochratoxin A	15-27	phenylalanine hydroxylase	Rattus norvegicus	47-72
33800744-0	2021	Transcriptome Analysis Reveals the AhR, Smad2/3, and HIF-1alpha Pathways as the Mechanism of Ochratoxin A Toxicity in Kidney Cells.	ochratoxin A	93-105	aryl hydrocarbon receptor	Homo sapiens	35-38
33800744-0	2021	Transcriptome Analysis Reveals the AhR, Smad2/3, and HIF-1alpha Pathways as the Mechanism of Ochratoxin A Toxicity in Kidney Cells.	ochratoxin A	93-105	SMAD family member 2	Homo sapiens	40-47
33800744-0	2021	Transcriptome Analysis Reveals the AhR, Smad2/3, and HIF-1alpha Pathways as the Mechanism of Ochratoxin A Toxicity in Kidney Cells.	ochratoxin A	93-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
2119584-1	1990	Lipid peroxidation, measured as malondialdehyde formation or by oxygen uptake, was stimulated markedly by the mycotoxin ochratoxin A (OTA) in a reconstituted system consisting of phospholipid vesicles, the flavoprotein NADPH-cytochrome P450 reductase, Fe3+, EDTA and NADPH.	ochratoxin A	120-132	cytochrome p450 oxidoreductase	Homo sapiens	219-250
34896195-0	2022	Corrigendum to "Ochratoxin A exposure decreased sperm motility via the AMPK and PTEN signaling pathways" (Toxicology and Applied Pharmacology 271 (2018) 49-57).	ochratoxin A	16-28	phosphatase and tensin homolog	Homo sapiens	80-84
34921099-10	2021	Renal OAT isoform expression (OAT1-5) in NASH mice decreasd by ~50% with reduced OTA uptake by proximal convoluted cells.	ochratoxin A	81-84	solute carrier family 22 (organic anion transporter), member 6	Mus musculus	30-36
34936334-0	2022	Correction to Ochratoxin A Exposure Impairs Porcine Granulosa Cell Growth via the PI3K/AKT Signaling Pathway.	ochratoxin A	14-26	AKT serine/threonine kinase 1	Homo sapiens	87-90
34322792-4	2022	Therefore, in this study, we aimed to examine the ability of BBP to remove other 12 mycotoxins (including aflatoxin B1, aflatoxin M1, citrinin, dihydrocitrinone, cyclopiazonic acid, deoxynivalenol, ochratoxin A, patulin, sterigmatocystin, zearalanone, alpha-zearalanol, and beta-zearalanol) from different buffers (pH 3.0, 5.0, and 7.0).	ochratoxin A	198-210	TM2 domain containing 1	Homo sapiens	61-64
34322792-6	2022	However, for the removal of ochratoxin A, BBP was far the most effective at pH 3.0.	ochratoxin A	28-40	TM2 domain containing 1	Homo sapiens	42-45
34968797-4	2021	Mechanistically, the signaling network evaluation suggested androgen receptor (AR)-linked signaling as a common pivotal cluster associated with metabolism- or hormone-related tumorigenesis in response to aflatoxin B1 and ochratoxin A co-exposure.	ochratoxin A	221-233	androgen receptor	Homo sapiens	60-77
34968797-4	2021	Mechanistically, the signaling network evaluation suggested androgen receptor (AR)-linked signaling as a common pivotal cluster associated with metabolism- or hormone-related tumorigenesis in response to aflatoxin B1 and ochratoxin A co-exposure.	ochratoxin A	221-233	androgen receptor	Homo sapiens	79-81
34717913-6	2022	Ochratoxin A also induced oxidative stress and lipid peroxidation in the bursa of Fabricius, spleen and thymus tissues of chickens as demonstrated by decreased CAT and GSH levels and increased TBARS content.	ochratoxin A	0-12	catalase	Gallus gallus	160-163
34822529-5	2021	OTA exposure significantly increased the nuclear translocation of NFkappaB, whereas we found a reduction in inflammation via NFkappaB inhibition with FKA treatment.	ochratoxin A	0-3	nuclear factor kappa B subunit 1	Homo sapiens	66-74
34822586-0	2021	Ochratoxin A Induces Steatosis via PPARgamma-CD36 Axis.	ochratoxin A	0-12	peroxisome proliferator activated receptor gamma	Homo sapiens	35-44
34681895-5	2021	Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement.	ochratoxin A	69-72	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
34822529-8	2021	Knockdown of Nrf2 through small interfering RNA (siRNA) impedes the protective role of FKA against the endothelial toxicity induced by OTA.	ochratoxin A	135-138	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
34681610-4	2021	OTA increased ER-stress-related JNK and precursor caspase-4 cleavage apoptotic pathways.	ochratoxin A	0-3	mitogen-activated protein kinase 8	Homo sapiens	32-35
34681610-4	2021	OTA increased ER-stress-related JNK and precursor caspase-4 cleavage apoptotic pathways.	ochratoxin A	0-3	caspase 4	Homo sapiens	50-59
34116085-0	2021	Ochratoxin A induces ERK1/2 phosphorylation-dependent apoptosis through NF-kappaB/ERK axis in human proximal tubule HK-2 cell line.	ochratoxin A	0-12	mitogen-activated protein kinase 3	Homo sapiens	21-27
34101318-0	2021	Ochratoxin A induces human kidney tubular epithelial cell apoptosis through regulating lipid raft/PTEN/AKT signaling pathway.	ochratoxin A	0-12	phosphatase and tensin homolog	Homo sapiens	98-102
34101318-0	2021	Ochratoxin A induces human kidney tubular epithelial cell apoptosis through regulating lipid raft/PTEN/AKT signaling pathway.	ochratoxin A	0-12	AKT serine/threonine kinase 1	Homo sapiens	103-106
34101318-3	2021	However, the toxic effects of OTA on human kidney tubular epithelial cell (HK-2) and the possible mechanism remains poorly understood.	ochratoxin A	30-33	hexokinase 2	Homo sapiens	75-79
34116085-0	2021	Ochratoxin A induces ERK1/2 phosphorylation-dependent apoptosis through NF-kappaB/ERK axis in human proximal tubule HK-2 cell line.	ochratoxin A	0-12	nuclear factor kappa B subunit 1	Homo sapiens	72-81
34116085-0	2021	Ochratoxin A induces ERK1/2 phosphorylation-dependent apoptosis through NF-kappaB/ERK axis in human proximal tubule HK-2 cell line.	ochratoxin A	0-12	mitogen-activated protein kinase 1	Homo sapiens	82-85
34116085-3	2021	OTA activates both MAPK/ERK and PI3K/Akt signaling pathways, which play role in apoptosis and cell survival, respectively.	ochratoxin A	0-3	mitogen-activated protein kinase 3	Homo sapiens	19-23
34116085-3	2021	OTA activates both MAPK/ERK and PI3K/Akt signaling pathways, which play role in apoptosis and cell survival, respectively.	ochratoxin A	0-3	mitogen-activated protein kinase 1	Homo sapiens	24-27
34116085-3	2021	OTA activates both MAPK/ERK and PI3K/Akt signaling pathways, which play role in apoptosis and cell survival, respectively.	ochratoxin A	0-3	AKT serine/threonine kinase 1	Homo sapiens	37-40
34116085-4	2021	OTA is also known to induce toxicity by activating the NF-kappaB pathway in immune cells.	ochratoxin A	0-3	nuclear factor kappa B subunit 1	Homo sapiens	55-64
35364054-0	2022	Ochratoxin A treated rat derived urinary exosomes enhanced cell growth and extracellular matrix production in normal kidney cells through modulation of TGF-beta1/smad2/3 signaling pathway.	ochratoxin A	0-12	transforming growth factor, beta 1	Rattus norvegicus	152-161
34204980-8	2021	The ochratoxin A was reduced by both extracts but only the extract TE2 was effective in reducing aflatoxins, whereas TE1 treatment increased their synthesis.	ochratoxin A	4-16	protein terminal ear1	Zea mays	117-120
35364054-0	2022	Ochratoxin A treated rat derived urinary exosomes enhanced cell growth and extracellular matrix production in normal kidney cells through modulation of TGF-beta1/smad2/3 signaling pathway.	ochratoxin A	0-12	SMAD family member 2	Rattus norvegicus	162-169
35364054-12	2022	SIGNIFICANCE: Our investigations exogenous exposure of OTA derived urinary exosomes caused TGF-beta1/smad2/3 pathway-mediated activation of pro-fibrotic changes in kidney will helpful for deeper understanding the OTA-induced nephrotoxicity.	ochratoxin A	213-216	transforming growth factor, beta 1	Rattus norvegicus	91-100
35576029-0	2022	Aspergillus awamori attenuates ochratoxin A-induced renal and cardiac injuries in rabbits by activating the Nrf2/HO-1 signaling pathway and downregulating IL1beta, TNFalpha, and iNOS gene expressions.	ochratoxin A	31-43	heme oxygenase 1	Oryctolagus cuniculus	113-117
35576029-0	2022	Aspergillus awamori attenuates ochratoxin A-induced renal and cardiac injuries in rabbits by activating the Nrf2/HO-1 signaling pathway and downregulating IL1beta, TNFalpha, and iNOS gene expressions.	ochratoxin A	31-43	interleukin-1 alpha	Oryctolagus cuniculus	155-162
35543154-0	2022	Ochratoxin a induces hepatic fibrosis through TGF-beta receptor I/Smad2/3 signaling pathway.	ochratoxin A	0-12	SMAD family member 2	Homo sapiens	66-73
35324704-6	2022	The outcomes highlighted that a low-frequency CYP2D6 variant (CYP2D6*110) is likely to enhance ochratoxin A oxidation with possible consequences on TK and TD.	ochratoxin A	95-107	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	46-52
35358920-10	2022	Knockdown of TLR4 alleviated the exacerbating effects of PCV2 infection on OTA-induced cytotoxicity, apoptosis and DNA damage in PAMs.	ochratoxin A	75-78	toll like receptor 4	Homo sapiens	13-17
35358920-11	2022	These results indicated that PCV2 infection aggravated OTA-induced immunotoxicity and reduced the dose of OTA-induced immunotoxicity via TLR4/NF-kappaB p65 signaling pathway, which could provide basis for establishing limits for OTA.	ochratoxin A	106-109	RELA proto-oncogene, NF-kB subunit	Homo sapiens	142-155
35324704-6	2022	The outcomes highlighted that a low-frequency CYP2D6 variant (CYP2D6*110) is likely to enhance ochratoxin A oxidation with possible consequences on TK and TD.	ochratoxin A	95-107	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	62-68
2569870-1	1989	The effect of ochratoxin A on the specific activities of phosphoenolpyruvate carboxykinase, gamma-glutamyl transpeptidase and phosphate-dependent glutaminase were investigated in primary cultures of rat kidney proximal convoluted tubule cells grown in a serum-free medium supplemented with growth factors.	ochratoxin A	14-26	gamma-glutamyltransferase 1	Rattus norvegicus	92-121
2569870-2	1989	Addition of ochratoxin A (25-100 microM) to the medium caused reduction in the specific activities of phosphoenolpyruvate carboxykinase and gamma-glutamyl transpeptidase only.	ochratoxin A	12-24	gamma-glutamyltransferase 1	Rattus norvegicus	140-169
2905799-8	1988	Hepatotoxicity of dietary ochratoxin A was evident through an observed significant reduction in serum levels of total protein, albumin, globulin, cholesterol, triglyceride, and blood urea nitrogen, and a significant increase in the serum activities of gamma glutamyl transferase and cholinesterase.	ochratoxin A	26-38	butyrylcholinesterase	Gallus gallus	283-297
3127983-2	1988	The specific antibodies used in this method had been prepared by the immunization of rabbits by means of administration of ochratoxin A conjugate with bovine serum albumin.	ochratoxin A	123-135	albumin	Oryctolagus cuniculus	158-171
6430866-3	1984	Detection limits are 5-7 micrograms aflatoxin B1 and 20 micrograms ochratoxin A/kg.	ochratoxin A	67-79	membrane spanning 4-domains A1	Homo sapiens	46-55
2891856-7	1988	When mitochondrial PEPCK activity present in the cytosolic fraction was accounted for, ochratoxin A was found to reduce PEPCK activity by 70-80%.	ochratoxin A	87-99	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	19-24
2891856-7	1988	When mitochondrial PEPCK activity present in the cytosolic fraction was accounted for, ochratoxin A was found to reduce PEPCK activity by 70-80%.	ochratoxin A	87-99	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	120-125
2891856-8	1988	The increase of ochratoxin A exposure from zero through 0.2 ppm to 1 ppm, which resulted in dose-dependent activity decrease of PEPCK and gamma-glutamyl transpeptidase, was accompanied by dose-dependent decrease of renal function, as measured by a reduction of maximal tubular excretion of para-aminohippurate per clearance of inulin (TmPAH/CIn) and an increase in glucose excretion.	ochratoxin A	16-28	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	128-133
2891856-8	1988	The increase of ochratoxin A exposure from zero through 0.2 ppm to 1 ppm, which resulted in dose-dependent activity decrease of PEPCK and gamma-glutamyl transpeptidase, was accompanied by dose-dependent decrease of renal function, as measured by a reduction of maximal tubular excretion of para-aminohippurate per clearance of inulin (TmPAH/CIn) and an increase in glucose excretion.	ochratoxin A	16-28	inactive glutathione hydrolase 2	Homo sapiens	138-167
2891856-8	1988	The increase of ochratoxin A exposure from zero through 0.2 ppm to 1 ppm, which resulted in dose-dependent activity decrease of PEPCK and gamma-glutamyl transpeptidase, was accompanied by dose-dependent decrease of renal function, as measured by a reduction of maximal tubular excretion of para-aminohippurate per clearance of inulin (TmPAH/CIn) and an increase in glucose excretion.	ochratoxin A	16-28	pyridoxal phosphatase	Homo sapiens	341-344
2891856-10	1988	Assuming that porcine nephropathy represents a valid model of endemic (Balkan) nephropathy in humans, the measurement of cytosolic PEPCK and gamma-glutamyl transpeptidase activity in the kidney could be a sensitive test for ochratoxin A-induced disease in humans.	ochratoxin A	224-236	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	131-136
2891856-10	1988	Assuming that porcine nephropathy represents a valid model of endemic (Balkan) nephropathy in humans, the measurement of cytosolic PEPCK and gamma-glutamyl transpeptidase activity in the kidney could be a sensitive test for ochratoxin A-induced disease in humans.	ochratoxin A	224-236	inactive glutathione hydrolase 2	Homo sapiens	141-170
3992601-1	1985	LD50 of ochratoxin A (OCT A) was estimated to be 29.4 mg/kg in intraperitoneal (i.p.)	ochratoxin A	8-20	plexin A2	Mus musculus	22-25
4109332-0	1971	Interaction of ochratoxin A with bovine serum albumin.	ochratoxin A	15-27	albumin	Homo sapiens	40-53
6347065-0	1983	Oxidation of two hydroxylated ochratoxin A metabolites by alcohol dehydrogenase.	ochratoxin A	30-42	aldo-keto reductase family 1 member A1	Homo sapiens	58-79
6863176-1	1983	The mycotoxin ochratoxin A (OA) was derivatized to an O-methyl,methyl ester (Me2) with diazomethane and then determined by high pressure liquid chromatography (HPLC).	ochratoxin A	14-26	malic enzyme 2	Homo sapiens	77-80
7396488-6	1980	These findings strongly suggest the involvement of a cytochrome P-450 in the hydroxylation of ochratoxin A by rat liver microsomes.	ochratoxin A	94-106	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	53-69
6859860-1	1983	Ochratoxin A, a nephrotoxin produced by Aspergillus ochraceus, decreases the activity of phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) in the cytosol of rat kidneys, as well as inhibits renal gluconeogenesis (Meisner, H., and Meisner, P. (1981) Arch.	ochratoxin A	0-12	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	144-149
6859860-5	1983	Ochratoxin A greatly reduces the level of translatable mRNA for PEPCK in kidneys of rats fed the toxin for 2 days, while the efficiency of translation of poly(A)+ RNA is not affected.	ochratoxin A	0-12	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	64-69
33158674-4	2021	Under the optimized conditions, the fluorescence intensity increased linearly with OTA concentration over the range of 10 pg mL-1-1 microg mL-1 with the detection limit of 0.247 pg mL-1.	ochratoxin A	83-86	L1 cell adhesion molecule	Mus musculus	125-129
33905761-0	2021	Non-cytotoxic dosage of fumonisin B1 aggravates ochratoxin A-induced nephrocytotoxicity and apoptosis via ROS-dependent JNK/MAPK signaling pathway.	ochratoxin A	48-60	mitogen-activated protein kinase 8	Sus scrofa	120-123
33905761-9	2021	Pretreatment with SP600125, a JNK inhibitor, could significantly block the promotion effects of FB1 on OTA-induced nephrocytotoxicity and apoptosis.	ochratoxin A	103-106	mitogen-activated protein kinase 8	Sus scrofa	30-33
33158674-4	2021	Under the optimized conditions, the fluorescence intensity increased linearly with OTA concentration over the range of 10 pg mL-1-1 microg mL-1 with the detection limit of 0.247 pg mL-1.	ochratoxin A	83-86	L1 cell adhesion molecule	Mus musculus	139-143
33158674-4	2021	Under the optimized conditions, the fluorescence intensity increased linearly with OTA concentration over the range of 10 pg mL-1-1 microg mL-1 with the detection limit of 0.247 pg mL-1.	ochratoxin A	83-86	L1 cell adhesion molecule	Mus musculus	139-143
32424756-8	2020	OTA administration activates various mechanisms such as p38 MAPK, JNKs, and ERKs dysfunctions, BDNF disruption, TH overexpression, caspase-3 and 9 activation, and ERK-1/2 phosphorylation which ultimately lead to Alzheimer disease (AD) progression.	ochratoxin A	0-3	brain derived neurotrophic factor	Homo sapiens	95-99
33543323-5	2021	OTA administration significantly increased histological injury and renal fibrosis molecules (alpha-SMA, Vimentin, TGF-beta) and activated the NOD-like receptor protein 3 (NLRP3) inflammasome and induced pyroptosis compared with control.	ochratoxin A	0-3	actin alpha 2, smooth muscle, aorta	Mus musculus	93-102
33543323-5	2021	OTA administration significantly increased histological injury and renal fibrosis molecules (alpha-SMA, Vimentin, TGF-beta) and activated the NOD-like receptor protein 3 (NLRP3) inflammasome and induced pyroptosis compared with control.	ochratoxin A	0-3	vimentin	Mus musculus	104-112
33543323-5	2021	OTA administration significantly increased histological injury and renal fibrosis molecules (alpha-SMA, Vimentin, TGF-beta) and activated the NOD-like receptor protein 3 (NLRP3) inflammasome and induced pyroptosis compared with control.	ochratoxin A	0-3	transforming growth factor alpha	Mus musculus	114-122
33543323-5	2021	OTA administration significantly increased histological injury and renal fibrosis molecules (alpha-SMA, Vimentin, TGF-beta) and activated the NOD-like receptor protein 3 (NLRP3) inflammasome and induced pyroptosis compared with control.	ochratoxin A	0-3	NLR family pyrin domain containing 3	Canis lupus familiaris	142-169
33543323-5	2021	OTA administration significantly increased histological injury and renal fibrosis molecules (alpha-SMA, Vimentin, TGF-beta) and activated the NOD-like receptor protein 3 (NLRP3) inflammasome and induced pyroptosis compared with control.	ochratoxin A	0-3	NLR family, pyrin domain containing 3	Mus musculus	171-176
33543323-7	2021	Data showed that OTA dose-dependently affected cell viability and significantly up-regulated renal fibrosis genes (alpha-SMA, Vimentin, TGF-beta).	ochratoxin A	17-20	actin alpha 2, smooth muscle, aorta	Mus musculus	115-124
33543323-7	2021	Data showed that OTA dose-dependently affected cell viability and significantly up-regulated renal fibrosis genes (alpha-SMA, Vimentin, TGF-beta).	ochratoxin A	17-20	vimentin	Canis lupus familiaris	126-134
33543323-7	2021	Data showed that OTA dose-dependently affected cell viability and significantly up-regulated renal fibrosis genes (alpha-SMA, Vimentin, TGF-beta).	ochratoxin A	17-20	protransforming growth factor alpha	Canis lupus familiaris	136-144
33543323-10	2021	Furthermore, knockdown of caspase-1 also ameliorated OTA-induced renal fibrosis via the inhibition of pyroptosis.	ochratoxin A	53-56	caspase-1	Canis lupus familiaris	26-35
33543323-11	2021	Collectively, the chosen doses of OTA-triggered nephrotoxicity through NLRP3 inflammasome activation and caspase-1-dependent pyroptosis both in vitro and in vivo.	ochratoxin A	34-37	NLR family pyrin domain containing 3	Canis lupus familiaris	71-76
33543323-11	2021	Collectively, the chosen doses of OTA-triggered nephrotoxicity through NLRP3 inflammasome activation and caspase-1-dependent pyroptosis both in vitro and in vivo.	ochratoxin A	34-37	caspase-1	Canis lupus familiaris	105-114
33465424-0	2021	Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A.	ochratoxin A	161-173	TNF receptor associated protein 1	Homo sapiens	16-21
33465424-7	2021	The pre-treatment of 2 muM OA for 2 h could remarkably relieve OTA-induced suppression of TRAP1 (P < 0.05).	ochratoxin A	63-66	TNF receptor associated protein 1	Homo sapiens	90-95
33465424-8	2021	In conclusion, TRAP1 played a central role in the ameliorative effect of OA on the mitochondrial-mediated and ERS-excitated apoptosis induced by OTA.	ochratoxin A	145-148	TNF receptor associated protein 1	Homo sapiens	15-20
32419674-1	2020	The aim of this study was to develop a highly-sensitive liquid chromatographic - tandem mass spectrometric (LC-MS/MS) method to investigate the presence of aflatoxins (AFB1, AFB2, AFG1 and AFG2) and ochratoxin A (OTA) in traditional homemade sausages (n = 88) collected from small family farms situated in different regions in Croatia.	ochratoxin A	199-211	spermatogenesis associated 5	Homo sapiens	189-193
33918675-7	2021	Finally, the mRNA level of catalase (CAT) was downregulated by 2.33-, 1.92-, and 1.82-fold after cells were treated with 1, 10, and 10 muM OTA for 24 h, respectively; which was linked to a decrease in CAT enzymatic activity.	ochratoxin A	139-142	catalase	Homo sapiens	27-35
33918675-7	2021	Finally, the mRNA level of catalase (CAT) was downregulated by 2.33-, 1.92-, and 1.82-fold after cells were treated with 1, 10, and 10 muM OTA for 24 h, respectively; which was linked to a decrease in CAT enzymatic activity.	ochratoxin A	139-142	catalase	Homo sapiens	37-40
33918675-7	2021	Finally, the mRNA level of catalase (CAT) was downregulated by 2.33-, 1.92-, and 1.82-fold after cells were treated with 1, 10, and 10 muM OTA for 24 h, respectively; which was linked to a decrease in CAT enzymatic activity.	ochratoxin A	139-142	catalase	Homo sapiens	201-204
33505592-0	2021	Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-kappaB Signaling Pathway.	ochratoxin A	23-35	myeloid differentiation primary response gene 88	Mus musculus	139-144
33505592-0	2021	Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-kappaB Signaling Pathway.	ochratoxin A	23-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
32424756-8	2020	OTA administration activates various mechanisms such as p38 MAPK, JNKs, and ERKs dysfunctions, BDNF disruption, TH overexpression, caspase-3 and 9 activation, and ERK-1/2 phosphorylation which ultimately lead to Alzheimer disease (AD) progression.	ochratoxin A	0-3	caspase 3	Homo sapiens	131-146
32424756-8	2020	OTA administration activates various mechanisms such as p38 MAPK, JNKs, and ERKs dysfunctions, BDNF disruption, TH overexpression, caspase-3 and 9 activation, and ERK-1/2 phosphorylation which ultimately lead to Alzheimer disease (AD) progression.	ochratoxin A	0-3	mitogen-activated protein kinase 3	Homo sapiens	163-170
32439592-8	2020	The results showed that LUT activated Nrf2 pathway and increased the antioxidant defense capacities of OTA treated cells.	ochratoxin A	103-106	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-42
32659470-0	2020	DECHLORINATION AND DEMETHYLATION OF OCHRATOXIN A ENHANCE BLOCKING ACTIVITY OF PXR ACTIVATION, SUPPRESS PXR EXPRESSION AND REDUCE CYTOTOXICITY.	ochratoxin A	36-48	nuclear receptor subfamily 1 group I member 2	Homo sapiens	78-81
32659470-0	2020	DECHLORINATION AND DEMETHYLATION OF OCHRATOXIN A ENHANCE BLOCKING ACTIVITY OF PXR ACTIVATION, SUPPRESS PXR EXPRESSION AND REDUCE CYTOTOXICITY.	ochratoxin A	36-48	nuclear receptor subfamily 1 group I member 2	Homo sapiens	103-106
32659470-2	2020	Ochratoxin A (OTA), a mycotoxin, decreases the expression of PXR protein in human primary hepatocytes.	ochratoxin A	0-12	nuclear receptor subfamily 1 group I member 2	Homo sapiens	61-64
32659470-2	2020	Ochratoxin A (OTA), a mycotoxin, decreases the expression of PXR protein in human primary hepatocytes.	ochratoxin A	14-17	nuclear receptor subfamily 1 group I member 2	Homo sapiens	61-64
32617660-0	2020	Ochratoxin A induces epithelial-to-mesenchymal transition and renal fibrosis through TGF-beta/Smad2/3 and Wnt1/beta-catenin signaling pathways in vitro and in vivo.	ochratoxin A	0-12	transforming growth factor alpha	Mus musculus	85-93
32617660-0	2020	Ochratoxin A induces epithelial-to-mesenchymal transition and renal fibrosis through TGF-beta/Smad2/3 and Wnt1/beta-catenin signaling pathways in vitro and in vivo.	ochratoxin A	0-12	SMAD family member 2	Mus musculus	94-101
32617660-0	2020	Ochratoxin A induces epithelial-to-mesenchymal transition and renal fibrosis through TGF-beta/Smad2/3 and Wnt1/beta-catenin signaling pathways in vitro and in vivo.	ochratoxin A	0-12	wingless-type MMTV integration site family, member 1	Mus musculus	106-110
32617660-0	2020	Ochratoxin A induces epithelial-to-mesenchymal transition and renal fibrosis through TGF-beta/Smad2/3 and Wnt1/beta-catenin signaling pathways in vitro and in vivo.	ochratoxin A	0-12	catenin (cadherin associated protein), beta 1	Mus musculus	111-123
32371067-4	2020	In the present study, we demonstrated that OTA treatment at 4.0-8.0 muM increased apoptosis in PK-15 cells as shown by increased the ratio of apoptosis and protein expression of Bax and cleaved-caspase-3, decreased protein expression of Bcl-2.	ochratoxin A	43-46	apoptosis regulator BAX	Sus scrofa	178-181
32371067-4	2020	In the present study, we demonstrated that OTA treatment at 4.0-8.0 muM increased apoptosis in PK-15 cells as shown by increased the ratio of apoptosis and protein expression of Bax and cleaved-caspase-3, decreased protein expression of Bcl-2.	ochratoxin A	43-46	apoptosis regulator Bcl-2	Sus scrofa	237-242
32371067-6	2020	Taurine supplementation decreased OTA-induced cytotoxicity and attenuated apoptosis as shown by the decreased Annexin V/PI staining and the decreased expression of apoptosis-related proteins including Bax and caspase-3.	ochratoxin A	34-37	apoptosis regulator BAX	Sus scrofa	201-204
32371067-6	2020	Taurine supplementation decreased OTA-induced cytotoxicity and attenuated apoptosis as shown by the decreased Annexin V/PI staining and the decreased expression of apoptosis-related proteins including Bax and caspase-3.	ochratoxin A	34-37	caspase 3	Sus scrofa	209-218
32615238-0	2020	Ochratoxin A induces glomerular injury through activating the ERK/NF-kappaB signaling pathway.	ochratoxin A	0-12	mitogen-activated protein kinase 1	Homo sapiens	62-65
32615238-0	2020	Ochratoxin A induces glomerular injury through activating the ERK/NF-kappaB signaling pathway.	ochratoxin A	0-12	nuclear factor kappa B subunit 1	Homo sapiens	66-75
32615238-10	2020	OTA-induced toxicity was attenuated by NF-kappaB and ERK1/2 inhibitors.	ochratoxin A	0-3	nuclear factor kappa B subunit 1	Homo sapiens	39-48
32615238-10	2020	OTA-induced toxicity was attenuated by NF-kappaB and ERK1/2 inhibitors.	ochratoxin A	0-3	mitogen-activated protein kinase 3	Homo sapiens	53-59
32615238-11	2020	In conclusion, these results suggest that OTA exposure induces glomerular injury via activation of the ERK/NF-kappaB signaling pathway, and provide novel insights into the research of OTA induced nephrotoxicity.	ochratoxin A	42-45	mitogen-activated protein kinase 1	Homo sapiens	103-106
32615238-11	2020	In conclusion, these results suggest that OTA exposure induces glomerular injury via activation of the ERK/NF-kappaB signaling pathway, and provide novel insights into the research of OTA induced nephrotoxicity.	ochratoxin A	42-45	nuclear factor kappa B subunit 1	Homo sapiens	107-116
32014670-2	2020	Here, a green electrochemical immunosensor for the ultrasensitive detection of ochratoxin A (OTA) was fabricated by self-assembling a compact 2-mercaptoacetic (TGA) monolayer on the surface of the working Au electrode to form the Au/TGA/bovine serum aibumin (BSA)-OTA/anti-OTA monoclonal antibody composite probes for selective and ultra-sensitive detection of OTA based on indirect competitive principle and differential pulse voltammetry analysis.	ochratoxin A	79-91	T-box transcription factor 1	Homo sapiens	160-163
32014670-2	2020	Here, a green electrochemical immunosensor for the ultrasensitive detection of ochratoxin A (OTA) was fabricated by self-assembling a compact 2-mercaptoacetic (TGA) monolayer on the surface of the working Au electrode to form the Au/TGA/bovine serum aibumin (BSA)-OTA/anti-OTA monoclonal antibody composite probes for selective and ultra-sensitive detection of OTA based on indirect competitive principle and differential pulse voltammetry analysis.	ochratoxin A	93-96	T-box transcription factor 1	Homo sapiens	160-163
32014670-2	2020	Here, a green electrochemical immunosensor for the ultrasensitive detection of ochratoxin A (OTA) was fabricated by self-assembling a compact 2-mercaptoacetic (TGA) monolayer on the surface of the working Au electrode to form the Au/TGA/bovine serum aibumin (BSA)-OTA/anti-OTA monoclonal antibody composite probes for selective and ultra-sensitive detection of OTA based on indirect competitive principle and differential pulse voltammetry analysis.	ochratoxin A	264-267	T-box transcription factor 1	Homo sapiens	160-163
32014670-2	2020	Here, a green electrochemical immunosensor for the ultrasensitive detection of ochratoxin A (OTA) was fabricated by self-assembling a compact 2-mercaptoacetic (TGA) monolayer on the surface of the working Au electrode to form the Au/TGA/bovine serum aibumin (BSA)-OTA/anti-OTA monoclonal antibody composite probes for selective and ultra-sensitive detection of OTA based on indirect competitive principle and differential pulse voltammetry analysis.	ochratoxin A	264-267	T-box transcription factor 1	Homo sapiens	160-163
32014670-2	2020	Here, a green electrochemical immunosensor for the ultrasensitive detection of ochratoxin A (OTA) was fabricated by self-assembling a compact 2-mercaptoacetic (TGA) monolayer on the surface of the working Au electrode to form the Au/TGA/bovine serum aibumin (BSA)-OTA/anti-OTA monoclonal antibody composite probes for selective and ultra-sensitive detection of OTA based on indirect competitive principle and differential pulse voltammetry analysis.	ochratoxin A	264-267	T-box transcription factor 1	Homo sapiens	160-163
32056954-8	2020	The limit of detection attained is 2.11 pg mL-1 and displays high stability whereby it retains 30.65% of activity after 48 h. The designed INFGN demonstrates remarkable discrimination of DON against similar mycotoxins (zearalenone and ochratoxin A).	ochratoxin A	235-247	L1 cell adhesion molecule	Mus musculus	43-47
32259553-0	2020	Ochratoxin a causes cell cycle arrest in G1 and G1/S phases through p53 in HK-2 cells.	ochratoxin A	0-12	tumor protein p53	Homo sapiens	68-71
31796354-1	2020	An innovative colorimetric method based on enzyme-induced gold nanoparticle aggregation was developed to detect the activity of alkaline phosphatase (ALP), and it was further applied to construct an aptasensor to monitor ochratoxin A (OTA) concentrations.	ochratoxin A	221-233	alkaline phosphatase, placental	Homo sapiens	150-153
31796354-1	2020	An innovative colorimetric method based on enzyme-induced gold nanoparticle aggregation was developed to detect the activity of alkaline phosphatase (ALP), and it was further applied to construct an aptasensor to monitor ochratoxin A (OTA) concentrations.	ochratoxin A	235-238	alkaline phosphatase, placental	Homo sapiens	128-148
31796354-1	2020	An innovative colorimetric method based on enzyme-induced gold nanoparticle aggregation was developed to detect the activity of alkaline phosphatase (ALP), and it was further applied to construct an aptasensor to monitor ochratoxin A (OTA) concentrations.	ochratoxin A	235-238	alkaline phosphatase, placental	Homo sapiens	150-153
31675585-7	2020	OTA-induced intracerebral hemorrhage and CtA vessel defects were partially reversed by the presence of miR-731 antagomir or the overexpression of prolactin receptor a (prlra); prlra is a downstream target of miR-731.	ochratoxin A	0-3	prolactin receptor a	Danio rerio	146-166
32190177-0	2020	Astaxanthin Protects Ochratoxin A-Induced Oxidative Stress and Apoptosis in the Heart via the Nrf2 Pathway.	ochratoxin A	21-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	94-98
32197464-0	2020	Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway.	ochratoxin A	36-48	nuclear factor, erythroid derived 2, like 2	Mus musculus	118-122
32197464-0	2020	Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway.	ochratoxin A	36-48	kelch-like ECH-associated protein 1	Mus musculus	123-128
31675585-0	2020	Ochratoxin A triggered intracerebral hemorrhage in embryonic zebrafish: Involvement of microRNA-731 and prolactin receptor.	ochratoxin A	0-12	microRNA 731	Danio rerio	87-99
31675585-0	2020	Ochratoxin A triggered intracerebral hemorrhage in embryonic zebrafish: Involvement of microRNA-731 and prolactin receptor.	ochratoxin A	0-12	prolactin receptor a	Danio rerio	104-122
31675585-7	2020	OTA-induced intracerebral hemorrhage and CtA vessel defects were partially reversed by the presence of miR-731 antagomir or the overexpression of prolactin receptor a (prlra); prlra is a downstream target of miR-731.	ochratoxin A	0-3	prolactin receptor a	Danio rerio	168-173
31675585-7	2020	OTA-induced intracerebral hemorrhage and CtA vessel defects were partially reversed by the presence of miR-731 antagomir or the overexpression of prolactin receptor a (prlra); prlra is a downstream target of miR-731.	ochratoxin A	0-3	prolactin receptor a	Danio rerio	176-181
31675585-4	2020	Large numbers of extravagated erythrocytes were observed in the midbrain/hindbrain areas of Tg(fli-1a:EGFP; gata1:DsRed) embryos following exposure to OTA.	ochratoxin A	151-154	Fli-1 proto-oncogene, ETS transcription factor	Danio rerio	95-101
31675585-7	2020	OTA-induced intracerebral hemorrhage and CtA vessel defects were partially reversed by the presence of miR-731 antagomir or the overexpression of prolactin receptor a (prlra); prlra is a downstream target of miR-731.	ochratoxin A	0-3	microRNA 731	Danio rerio	103-110
31675585-7	2020	OTA-induced intracerebral hemorrhage and CtA vessel defects were partially reversed by the presence of miR-731 antagomir or the overexpression of prolactin receptor a (prlra); prlra is a downstream target of miR-731.	ochratoxin A	0-3	microRNA 731	Danio rerio	208-215
31675585-8	2020	These results suggest that exposure to OTA has a negative effect on cerebral vasculature development by interfering with the miR-731/PRLR axis in zebrafish.	ochratoxin A	39-42	microRNA 731	Danio rerio	125-132
31675585-8	2020	These results suggest that exposure to OTA has a negative effect on cerebral vasculature development by interfering with the miR-731/PRLR axis in zebrafish.	ochratoxin A	39-42	prolactin receptor a	Danio rerio	133-137
31790739-0	2020	GPx1-mediated DNMT1 expression is involved in the blocking effects of selenium on OTA-induced cytotoxicity and DNA damage.	ochratoxin A	82-85	glutathione peroxidase 1	Homo sapiens	0-4
31843237-5	2020	A novel OTA degrading gene carboxypeptidase cp4 was successfully cloned and characterized from CW239.	ochratoxin A	8-11	surfactant protein D	Rattus norvegicus	44-47
31843237-7	2020	The recombinant protein rCP4 was purified, and the OTA-degrading activity was evaluated.	ochratoxin A	51-54	surfactant protein D	Rattus norvegicus	24-28
31790739-0	2020	GPx1-mediated DNMT1 expression is involved in the blocking effects of selenium on OTA-induced cytotoxicity and DNA damage.	ochratoxin A	82-85	DNA methyltransferase 1	Homo sapiens	14-19
31790739-10	2020	The results suggest that GPx1-mediated DNMT1 expression is involved in the blocking effects of selenium on OTA-induced cytotoxicity and DNA damage.	ochratoxin A	107-110	DNA methyltransferase 1	Homo sapiens	39-44
31790739-3	2020	To date, little is known about the effect of Se on OTA-induced DNA damage.	ochratoxin A	51-54	squalene epoxidase	Homo sapiens	45-47
31843237-8	2020	Although OTA was efficiently degraded by CW239 (24-h degradation ratio of 86.2%), the 24-h OTA degradation ratio for rCP4 was only 36.8% at fairly high concentration (0.25 mg/mL) protein.	ochratoxin A	91-94	surfactant protein D	Rattus norvegicus	117-121
31843237-10	2020	Based on the serial investigations of this study, OTA might be simultaneously co-degraded by CP4 and another unknown degrading agent in that degrading strain.	ochratoxin A	50-53	surfactant protein D	Rattus norvegicus	93-96
31790739-8	2020	Overexpression of GPx1 by pcDNA3.1-GPx1 inhibited the OTA-induced DNMT1 expression, promoted OTA-induced SOCS3 expression, and prevented the OTA-induced cytotoxicity and DNA damage.	ochratoxin A	54-57	glutathione peroxidase 1	Homo sapiens	18-22
31790739-8	2020	Overexpression of GPx1 by pcDNA3.1-GPx1 inhibited the OTA-induced DNMT1 expression, promoted OTA-induced SOCS3 expression, and prevented the OTA-induced cytotoxicity and DNA damage.	ochratoxin A	54-57	glutathione peroxidase 1	Homo sapiens	35-39
31790739-8	2020	Overexpression of GPx1 by pcDNA3.1-GPx1 inhibited the OTA-induced DNMT1 expression, promoted OTA-induced SOCS3 expression, and prevented the OTA-induced cytotoxicity and DNA damage.	ochratoxin A	54-57	DNA methyltransferase 1	Homo sapiens	66-71
31790739-8	2020	Overexpression of GPx1 by pcDNA3.1-GPx1 inhibited the OTA-induced DNMT1 expression, promoted OTA-induced SOCS3 expression, and prevented the OTA-induced cytotoxicity and DNA damage.	ochratoxin A	93-96	glutathione peroxidase 1	Homo sapiens	18-22
31790739-8	2020	Overexpression of GPx1 by pcDNA3.1-GPx1 inhibited the OTA-induced DNMT1 expression, promoted OTA-induced SOCS3 expression, and prevented the OTA-induced cytotoxicity and DNA damage.	ochratoxin A	93-96	glutathione peroxidase 1	Homo sapiens	35-39
31790739-8	2020	Overexpression of GPx1 by pcDNA3.1-GPx1 inhibited the OTA-induced DNMT1 expression, promoted OTA-induced SOCS3 expression, and prevented the OTA-induced cytotoxicity and DNA damage.	ochratoxin A	93-96	suppressor of cytokine signaling 3	Homo sapiens	105-110
31790739-8	2020	Overexpression of GPx1 by pcDNA3.1-GPx1 inhibited the OTA-induced DNMT1 expression, promoted OTA-induced SOCS3 expression, and prevented the OTA-induced cytotoxicity and DNA damage.	ochratoxin A	93-96	glutathione peroxidase 1	Homo sapiens	18-22
31790739-8	2020	Overexpression of GPx1 by pcDNA3.1-GPx1 inhibited the OTA-induced DNMT1 expression, promoted OTA-induced SOCS3 expression, and prevented the OTA-induced cytotoxicity and DNA damage.	ochratoxin A	93-96	glutathione peroxidase 1	Homo sapiens	35-39
31790739-8	2020	Overexpression of GPx1 by pcDNA3.1-GPx1 inhibited the OTA-induced DNMT1 expression, promoted OTA-induced SOCS3 expression, and prevented the OTA-induced cytotoxicity and DNA damage.	ochratoxin A	93-96	suppressor of cytokine signaling 3	Homo sapiens	105-110
31790739-10	2020	The results suggest that GPx1-mediated DNMT1 expression is involved in the blocking effects of selenium on OTA-induced cytotoxicity and DNA damage.	ochratoxin A	107-110	glutathione peroxidase 1	Homo sapiens	25-29
32106596-0	2020	Selenium Yeast Alleviates Ochratoxin A-Induced Hepatotoxicity via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in Chickens.	ochratoxin A	26-38	kelch like ECH associated protein 1	Gallus gallus	102-107
32108135-0	2020	Nontoxic concentration of ochratoxin A decreases the dosage of cyclosporine A to induce chronic nephropathy model via autophagy mediated by toll-like receptor 4.	ochratoxin A	26-38	toll-like receptor 4	Mus musculus	140-160
32148649-0	2020	Selenium Yeast Alleviates Ochratoxin A-Induced Apoptosis and Oxidative Stress via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in the Kidneys of Chickens.	ochratoxin A	26-38	kelch like ECH associated protein 1	Gallus gallus	118-123
31976658-2	2020	In this work, we developed an economical and sensitive quantum dots (QDs)/QD microbead (QDs/QB)-based multiplex immunochromatographic assay (mICA) for the rapid detection of fumonisin B1 (FB1), zearalenone (ZEN), and ochratoxin A (OTA) without the building-up process of mycotoxin conjugates.	ochratoxin A	217-229	inhibitor of carbonic anhydrase	Mus musculus	141-145
32036964-8	2020	OTA decreased liver catalase (CAT) activity in ducks (P &lt; 0.05), while addition of curcumin in OTA group increased liver CAT activity (P &lt; 0.05).	ochratoxin A	0-3	catalase	Anas platyrhynchos	30-33
32036964-8	2020	OTA decreased liver catalase (CAT) activity in ducks (P &lt; 0.05), while addition of curcumin in OTA group increased liver CAT activity (P &lt; 0.05).	ochratoxin A	98-101	catalase	Anas platyrhynchos	124-127
31956515-5	2020	Treatment of Ochratoxin A alone (group 2 rats) significantly increased malondialdehyde content, catalase, and glutathione reductase activities with a decrease in the activity of superoxide dismutase enzyme and reduced glutathione level and in brain, kidney and liver.	ochratoxin A	13-25	catalase	Rattus norvegicus	96-104
31956515-5	2020	Treatment of Ochratoxin A alone (group 2 rats) significantly increased malondialdehyde content, catalase, and glutathione reductase activities with a decrease in the activity of superoxide dismutase enzyme and reduced glutathione level and in brain, kidney and liver.	ochratoxin A	13-25	glutathione-disulfide reductase	Rattus norvegicus	110-131
31936152-4	2020	Differential expression analyses revealed that OTA led to the regulation of gene expression in kidney human cell lines, including for genes enriched in cell cycle-related pathways, and OTA-induced gap 1 and 2 (G1 and G2) cell-cycle arrests were observed.	ochratoxin A	185-188	proline rich protein BstNI subfamily 3	Homo sapiens	197-219
31678613-0	2020	Amelioration of ochratoxin-A induced cytotoxicity by prophylactic treatment of N-Acetyl-L-Tryptophan in human embryonic kidney cells.	ochratoxin A	16-28	bromodomain containing 2	Homo sapiens	79-100
31678613-2	2020	In the present study protective efficacy of N-Acetyl-L-Tryptophan (NAT) against OTA induced toxicity was evaluated using Human Embryonic Kidney (HEK-293) cells.	ochratoxin A	80-83	bromodomain containing 2	Homo sapiens	44-65
31678613-2	2020	In the present study protective efficacy of N-Acetyl-L-Tryptophan (NAT) against OTA induced toxicity was evaluated using Human Embryonic Kidney (HEK-293) cells.	ochratoxin A	80-83	bromodomain containing 2	Homo sapiens	67-70
31936152-7	2020	We, therefore, propose CDK2 as one of the key regulators of the G1 cell-cycle arrest induced by low nanomolar concentrations of OTA.	ochratoxin A	128-131	cyclin dependent kinase 2	Homo sapiens	23-27
31678613-4	2020	OTA-induced intracellular ROS generation and its inhibition by NAT (2.5 microg/ml) pre-treatment was evaluated using 2",7"-dichlorodihydrofluorescein diacetate (H2DCFDA) probe.	ochratoxin A	0-3	bromodomain containing 2	Homo sapiens	63-66
31678613-5	2020	Effects of NAT pre-treatment on OTA treated cells were also evaluated in terms of cell cycle perturbations and mitochondrial membrane potential disturbance using flowcytometry.	ochratoxin A	32-35	bromodomain containing 2	Homo sapiens	11-14
31678613-6	2020	Results of the study demonstrated significant (~89 % cell growth in comparison to 50% in OTA alone group; P &lt; 0.05) protection by NAT to the HEK-293 cells against OTA mediated cell death in terms of cell viability.	ochratoxin A	89-92	bromodomain containing 2	Homo sapiens	133-136
31678613-6	2020	Results of the study demonstrated significant (~89 % cell growth in comparison to 50% in OTA alone group; P &lt; 0.05) protection by NAT to the HEK-293 cells against OTA mediated cell death in terms of cell viability.	ochratoxin A	166-169	bromodomain containing 2	Homo sapiens	133-136
31678613-7	2020	Further, significant reduction in ROS levels and mitochondrial membrane potential disturbance was also observed in NAT pre-treated plus OTA cells as compared to only OTA treated cells.	ochratoxin A	136-139	bromodomain containing 2	Homo sapiens	115-118
31678613-7	2020	Further, significant reduction in ROS levels and mitochondrial membrane potential disturbance was also observed in NAT pre-treated plus OTA cells as compared to only OTA treated cells.	ochratoxin A	166-169	bromodomain containing 2	Homo sapiens	115-118
31678613-8	2020	Significant (p &lt; 0.05) arrest in G0 and S phase of cell cycle was observed in OTA treated cells that was found to be inhibited by NAT pre-treatment to OTA treated cells.	ochratoxin A	81-84	bromodomain containing 2	Homo sapiens	133-136
31678613-8	2020	Significant (p &lt; 0.05) arrest in G0 and S phase of cell cycle was observed in OTA treated cells that was found to be inhibited by NAT pre-treatment to OTA treated cells.	ochratoxin A	154-157	bromodomain containing 2	Homo sapiens	133-136
31678613-9	2020	Also, molecular docking analysis demonstrated higher probability of NAT to bind with OTA binding pocket on phenylalanyl t-RNA synthetase, resulting in inhibition of OTA incorporation in the newly synthesized peptides and thus may ameliorate OTA induced protein synthesis inhibition.	ochratoxin A	85-88	bromodomain containing 2	Homo sapiens	68-71
31678613-9	2020	Also, molecular docking analysis demonstrated higher probability of NAT to bind with OTA binding pocket on phenylalanyl t-RNA synthetase, resulting in inhibition of OTA incorporation in the newly synthesized peptides and thus may ameliorate OTA induced protein synthesis inhibition.	ochratoxin A	165-168	bromodomain containing 2	Homo sapiens	68-71
31678613-9	2020	Also, molecular docking analysis demonstrated higher probability of NAT to bind with OTA binding pocket on phenylalanyl t-RNA synthetase, resulting in inhibition of OTA incorporation in the newly synthesized peptides and thus may ameliorate OTA induced protein synthesis inhibition.	ochratoxin A	165-168	bromodomain containing 2	Homo sapiens	68-71
31678613-10	2020	Conclusively, present study suggested that NAT offers protection against OTA toxicity in HEK-293 cells by counterbalancing oxidative stress, cell cycle regulation, mitochondrial membrane potential stabilization, protein synthesis inhibition and cell death retardation.	ochratoxin A	73-76	bromodomain containing 2	Homo sapiens	43-46
31912309-10	2020	Graphical abstractSchematic representation of OTA and FB1 detection based on Apt2-AuNRs-Fc/Apt1-AuNRs-Th/cDNA/AuE.	ochratoxin A	46-49	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	77-81
31912309-10	2020	Graphical abstractSchematic representation of OTA and FB1 detection based on Apt2-AuNRs-Fc/Apt1-AuNRs-Th/cDNA/AuE.	ochratoxin A	46-49	lysophospholipase 1	Homo sapiens	91-95
31936152-6	2020	CDK2 was downregulated by OTA exposure, and its overexpression partially blocked the OTA-induced G1 but not G2 cell-cycle arrest.	ochratoxin A	26-29	cyclin dependent kinase 2	Homo sapiens	0-4
31936152-6	2020	CDK2 was downregulated by OTA exposure, and its overexpression partially blocked the OTA-induced G1 but not G2 cell-cycle arrest.	ochratoxin A	85-88	cyclin dependent kinase 2	Homo sapiens	0-4
32879208-8	2020	The expression levels of CYP enzymes CYP1A1 and CYP1A2 involved in the phase I reaction significantly increased when the cells were treated with OTA and AA in combination.	ochratoxin A	145-148	peptidylprolyl isomerase G	Homo sapiens	25-28
32879208-8	2020	The expression levels of CYP enzymes CYP1A1 and CYP1A2 involved in the phase I reaction significantly increased when the cells were treated with OTA and AA in combination.	ochratoxin A	145-148	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	37-43
32879208-8	2020	The expression levels of CYP enzymes CYP1A1 and CYP1A2 involved in the phase I reaction significantly increased when the cells were treated with OTA and AA in combination.	ochratoxin A	145-148	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	48-54
31672358-6	2020	The cellular changes following OTA treatment are examined, and the results show that OTA adversely affects oocyte polar body extrusion, which is confirmed by the delay of Cdc2-mediated cell cycle progression.	ochratoxin A	85-88	cyclin dependent kinase 1	Homo sapiens	171-175
31610259-10	2020	Depending on the excretion rate considered for the PDI calculation, the risk assessed for the average OTA contamination varied from 10% to 194%, indicating a potential concern.	ochratoxin A	102-105	peptidyl arginine deiminase 1	Homo sapiens	51-54
31653047-2	2019	We and others have previously shown that OTA causes sustained activation of PI3K/AKT and MAPK/ERK1-2 signaling pathways in different cell types and animal models.	ochratoxin A	41-44	AKT serine/threonine kinase 1	Homo sapiens	81-84
31369848-4	2019	In this proteomic study of rat kidneys, 75 kd glucose-regulated protein (Grp75) expression was found to be sensitized by a low concentration of OTA, but inhibited by high doses.	ochratoxin A	144-147	heat shock protein family A (Hsp70) member 9	Rattus norvegicus	73-78
31415839-11	2019	The OTA-induced increase of COX-2 in NRK-49F cells was prevented by inhibition of miR-21 and -200a or ERK1/2.	ochratoxin A	4-7	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	28-33
31415839-11	2019	The OTA-induced increase of COX-2 in NRK-49F cells was prevented by inhibition of miR-21 and -200a or ERK1/2.	ochratoxin A	4-7	microRNA 21	Rattus norvegicus	82-88
31415839-11	2019	The OTA-induced increase of COX-2 in NRK-49F cells was prevented by inhibition of miR-21 and -200a or ERK1/2.	ochratoxin A	4-7	mitogen activated protein kinase 3	Rattus norvegicus	102-108
31653047-2	2019	We and others have previously shown that OTA causes sustained activation of PI3K/AKT and MAPK/ERK1-2 signaling pathways in different cell types and animal models.	ochratoxin A	41-44	mitogen-activated protein kinase 3	Homo sapiens	94-100
31653047-3	2019	Given the close relationship between cellular signaling activity and protein stability, we were curious whether increased PI3K/AKT and MAPK/ERK1-2 signaling may be the result of OTA-stimulated alterations in proteolytic activity.	ochratoxin A	178-181	AKT serine/threonine kinase 1	Homo sapiens	127-130
31653047-3	2019	Given the close relationship between cellular signaling activity and protein stability, we were curious whether increased PI3K/AKT and MAPK/ERK1-2 signaling may be the result of OTA-stimulated alterations in proteolytic activity.	ochratoxin A	178-181	mitogen-activated protein kinase 3	Homo sapiens	140-146
31653047-10	2019	Our results suggest that autophagy and subsequent UPS activation are responsible for sustained activation of PI3K/AKT and MAPK/ERK1-2 pathways through regulating the levels of critical phosphatases VHR/DUSP3, DUSP4, and PHLPP, which are known to be involved in OTA toxicity and carcinogenicity.	ochratoxin A	261-264	AKT serine/threonine kinase 1	Homo sapiens	114-117
31653047-10	2019	Our results suggest that autophagy and subsequent UPS activation are responsible for sustained activation of PI3K/AKT and MAPK/ERK1-2 pathways through regulating the levels of critical phosphatases VHR/DUSP3, DUSP4, and PHLPP, which are known to be involved in OTA toxicity and carcinogenicity.	ochratoxin A	261-264	mitogen-activated protein kinase 3	Homo sapiens	127-133
31296662-8	2019	We noted that Pdr1 is the most promiscuous activator, whereas Yrr1 and Stb5 are selective for ochratoxin A and hydrogen peroxide, respectively.	ochratoxin A	94-106	Yrr1p	Saccharomyces cerevisiae S288C	62-66
31523955-0	2019	Ochratoxin A triggered chicken heterophil extracellular traps release through ROS production dependent on activation of NADPH oxidase, ERK and p38 MAPK signaling pathways.	ochratoxin A	0-12	adapter molecule crk	Gallus gallus	143-146
31356822-0	2019	Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.	ochratoxin A	39-51	lon peptidase 1, mitochondrial	Homo sapiens	91-96
31356822-0	2019	Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.	ochratoxin A	39-51	aconitase 2	Homo sapiens	97-101
31356822-0	2019	Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.	ochratoxin A	39-51	TNF receptor associated protein 1	Homo sapiens	102-107
31154016-7	2019	Ochratoxin A reduced cell proliferation with sub G0/G1 cell cycle arrest by inhibiting CCND1, CCNE1, CDK4, and MYC expression.	ochratoxin A	0-12	cyclin D1	Homo sapiens	87-92
31154016-7	2019	Ochratoxin A reduced cell proliferation with sub G0/G1 cell cycle arrest by inhibiting CCND1, CCNE1, CDK4, and MYC expression.	ochratoxin A	0-12	cyclin E1	Homo sapiens	94-99
31154016-7	2019	Ochratoxin A reduced cell proliferation with sub G0/G1 cell cycle arrest by inhibiting CCND1, CCNE1, CDK4, and MYC expression.	ochratoxin A	0-12	cyclin dependent kinase 4	Homo sapiens	101-105
31154016-7	2019	Ochratoxin A reduced cell proliferation with sub G0/G1 cell cycle arrest by inhibiting CCND1, CCNE1, CDK4, and MYC expression.	ochratoxin A	0-12	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	111-114
31154016-9	2019	In addition, ochratoxin A increased cytosolic and mitochondrial calcium levels, resulting in an increase in MMP2 and PLAUR mRNA expression in NHA-SV40LT cells.	ochratoxin A	13-25	matrix metallopeptidase 2	Homo sapiens	108-112
31154016-9	2019	In addition, ochratoxin A increased cytosolic and mitochondrial calcium levels, resulting in an increase in MMP2 and PLAUR mRNA expression in NHA-SV40LT cells.	ochratoxin A	13-25	plasminogen activator, urokinase receptor	Homo sapiens	117-122
31154016-10	2019	Furthermore, ochratoxin A regulated the phosphorylation of AKT, ERK1/2, and JNK signal molecules of human astrocytes.	ochratoxin A	13-25	AKT serine/threonine kinase 1	Homo sapiens	59-62
31154016-10	2019	Furthermore, ochratoxin A regulated the phosphorylation of AKT, ERK1/2, and JNK signal molecules of human astrocytes.	ochratoxin A	13-25	mitogen-activated protein kinase 3	Homo sapiens	64-70
31154016-10	2019	Furthermore, ochratoxin A regulated the phosphorylation of AKT, ERK1/2, and JNK signal molecules of human astrocytes.	ochratoxin A	13-25	mitogen-activated protein kinase 8	Homo sapiens	76-79
31296662-8	2019	We noted that Pdr1 is the most promiscuous activator, whereas Yrr1 and Stb5 are selective for ochratoxin A and hydrogen peroxide, respectively.	ochratoxin A	94-106	Stb5p	Saccharomyces cerevisiae S288C	71-75
31339724-4	2019	Herein, we present for the first time a novel ratiometric mICA strip with multiple T lines for the simultaneous quantitative detection of aflatoxin B1 (AFB1), fumonisin B1 (FB1), and ochratoxin A (OTA) using highly luminescent quantum dot nanobeads (QBs) as enhanced signal reporters.	ochratoxin A	183-195	inhibitor of carbonic anhydrase	Mus musculus	58-62
31382421-0	2019	Analysis of the Carry-Over of Ochratoxin A from Feed to Milk, Blood, Urine, and Different Tissues of Dairy Cows Based on the Establishment of a Reliable LC-MS/MS Method.	ochratoxin A	30-42	Weaning weight-maternal milk	Bos taurus	56-60
31382421-1	2019	A rapid and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for simultaneous determination of ochratoxin A (OTA) and its metabolite ochratoxin alpha (OTalpha), for the first time, in dairy cow plasma, milk, urine, heart, liver, spleen, lung, and kidney.	ochratoxin A	134-146	Weaning weight-maternal milk	Bos taurus	241-245