PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2723655-7	1989	When the cells were treated with p-chloromercuribenzoate, dopamine-beta-hydroxylase, an enzyme present in the chromaffin granules along with catecholamines, was also released.	p-chloromercuribenzoate	33-56	dopamine beta-hydroxylase	Bos taurus	58-83
2288984-5	1990	The temperature optimum of the enzyme activity lies at 37 degrees C. The proteinase is completely inactivated by the specific inhibitors of serine proteinases, diisopropylfluorophosphate and phenylmethylsulfonylfluoride, as well as by the SH-group reagent, p-chloromercuribenzoate.	p-chloromercuribenzoate	257-280	endogenous retrovirus group K member 19, envelope	Homo sapiens	73-83
2721447-2	1989	[125I]CCK octapeptide binding was significantly reduced when gastric glands were pretreated with iodoacetamide (IA; 10 mM), p-chloromercuribenzoate (PCMB; 0.1 mM), or N-ethylmaleimide (NEM; 0.1 mM) at 24 C, but not by dithiothreitol (DTT; 1.0 mM) or dinitrothiobenzoic acid (DTNB; 10 mM).	p-chloromercuribenzoate	124-147	cholecystokinin	Cavia porcellus	6-9
2461933-6	1988	At 0.5 mM p-chloromercuribenzoate, about 50% of the MBP-specific enzyme remained as active, while most of the histone-specific enzyme activity was lost.	p-chloromercuribenzoate	10-33	myelin basic protein	Bos taurus	52-55
2439479-6	1987	p-Chloromercuribenzoate, a non-specific inhibitor of glycogen phosphorylase activity, reduced the formation of final reaction product attributable to phosphorylase activity completely.	p-chloromercuribenzoate	0-23	glycogen phosphorylase L	Rattus norvegicus	53-75
2457025-9	1988	Cytochrome c reduction was not inhibited by several mitochondrial respiratory chain inhibitors (azide, cyanide, and rotenone) but was sensitive to thiol-reactive agents (p-chloromercuribenzoate and monoiodo acetate).	p-chloromercuribenzoate	170-193	cytochrome c, somatic	Homo sapiens	0-12
3345734-2	1988	Oxidized glutathione and iodoacetate do not alter ADA activity, while the treatment with p-chloromercuribenzoate at similar concentrations results in a reduction of enzymatic activity which is statistically significant only for ADA 1, but not ADA 2-1 phenotype haemolysates.	p-chloromercuribenzoate	89-112	transcriptional adaptor 1	Homo sapiens	228-233
3345734-2	1988	Oxidized glutathione and iodoacetate do not alter ADA activity, while the treatment with p-chloromercuribenzoate at similar concentrations results in a reduction of enzymatic activity which is statistically significant only for ADA 1, but not ADA 2-1 phenotype haemolysates.	p-chloromercuribenzoate	89-112	adenosine deaminase	Homo sapiens	228-231
3581287-4	1987	trans-4-Hydroxy-alkenals and non-hydroxylated alpha,beta-unsaturated aldehydes may be exerting their effects on cytochrome P-450 by binding to sulfhydryl groups in a similar manner as reported for sulfhydryl reagents such as p-chloromercuriphenylsulfonic acid and p-chloromercuribenzoate.	p-chloromercuribenzoate	264-287	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	112-128
3450105-6	1987	Purified GDH was inhibited by p-chloromercuribenzoate and glucose 6-phosphate.	p-chloromercuribenzoate	30-53	glucose dehydrogenase	Bos taurus	9-12
2942643-7	1986	Dicyclohexylcarbodiimide, 2,4-dinitrophenol, trifluoperazine, chlorpromazine, and p-chloromercuribenzoate (50 microM) inhibit the ecto-ATPase, whereas ouabain (1 mM) and oligomycin (3.5 micrograms X mg-1 protein) show little or no inhibition of this enzyme activity.	p-chloromercuribenzoate	82-105	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	199-203
3541787-3	1986	Typical of similar enzymes in other species, gerbil AR1 reduced aliphatic and aromatic aldehydes and was inhibited by phenobarbital or valproate, whereas CR1 and CR2 catalyzed the reduction of aromatic aldehydes and ketones as well as quinones and were inhibited by p-chloromercuribenzoate, mercuric chloride, or pyrazole.	p-chloromercuribenzoate	266-289	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	154-157
3821393-12	1986	p-Chloromercuribenzoate markedly inhibited enzyme activity, suggesting that phospholipase C is a -SH enzyme.	p-chloromercuribenzoate	0-23	LOC100009319	Oryctolagus cuniculus	76-91
3461459-5	1986	Both polypeptides contain reactive thiol groups, but the rate of disruption of CRBP II-retinol complexes by p-chloromercuribenzoate is greater than that of CRBP-retinol.	p-chloromercuribenzoate	108-131	retinol binding protein 2	Rattus norvegicus	79-86
3461459-5	1986	Both polypeptides contain reactive thiol groups, but the rate of disruption of CRBP II-retinol complexes by p-chloromercuribenzoate is greater than that of CRBP-retinol.	p-chloromercuribenzoate	108-131	retinol binding protein 1	Rattus norvegicus	79-83
4052110-3	1985	Ca2+ sequestration was inhibited by reagents that cause alkylation (e.g. p-chloromercuribenzoate) or oxidation (e.g. diamide) of protein sulfhydryl groups.	p-chloromercuribenzoate	73-96	carbonic anhydrase 2	Rattus norvegicus	0-3
2991010-4	1985	The enzyme is a metalloproteinase inhibited by low concentrations of the chelating agents EDTA, 1, 10-phenanthroline, alpha alpha"-dipyridyl, and not affected by diisopropylfluorophosphate, soybean trypsin inhibitor, and p-chloromercuribenzoate.	p-chloromercuribenzoate	221-244	metalloendoproteinase 1	Glycine max	16-33
2996495-4	1985	Inhibition studies with p-chloromercuribenzoate and N-ethylmaleimide indicate that ketohexokinase contains thiol groups, which are required for full activity.	p-chloromercuribenzoate	24-47	ketohexokinase	Homo sapiens	83-97
2995356-5	1985	Using homogenization conditions that preclude this proteolysis (low pH and the addition of the protease inhibitor p-chloromercuribenzoate) and immunoblotting as an assay for the protein, a procedure for the purification of ubiquitin from etiolated oat shoots was developed.	p-chloromercuribenzoate	114-137	ubiquitin	Oryctolagus cuniculus	223-232
4019503-6	1985	The carboxypeptidase B which converts the oxytocinyl peptides showed a fairly sharp pH dependence with an optimum of 5.5-6, was activated by cobalt ion, and was inhibited by cupric ion, EDTA, and a thiol protease inhibitor, p-chloromercuribenzoate.	p-chloromercuribenzoate	224-247	carboxypeptidase B1	Bos taurus	4-22
6871231-7	1983	A correlation was found between the inhibition of O2- formation caused by the SH reagent p-chloromercuribenzoate and the alterations induced by this compound on the Em of cytochrome b.	p-chloromercuribenzoate	89-112	cytochrome b	Cavia porcellus	171-183
3911953-2	1985	The enzyme which likely belongs to the class of insulin-glucagon-proteinases, can be inhibited by chelating agents, such as ethylenediamine tetraacetic acid and o-phenanthroline, thiol blocking reagents, such as p-chloromercuribenzoate and N-ethylmaleimide as well as by proteinase inhibitors directed against serine proteinases, such as Contrykal and Trasylol.	p-chloromercuribenzoate	212-235	insulin	Homo sapiens	48-55
3925401-1	1985	Chemical modification studies on homogeneous bovine lens aldose reductase using diethylpyrocarbonate, phenylglyoxal, butanedione, N-ethylmaleimide and p-chloromercuribenzoate indicate that histidine and arginine residues located at or near the nucleotide binding site may be important in binding or orientation of the NADPH, and that NADPH oxidation with glucose requires protein thiol.	p-chloromercuribenzoate	151-174	aldose reductase	Bos taurus	57-73
2984192-6	1985	Inhibition of the active oxidase complex by p-chloromercuribenzoate also inhibited electron flow from NADPH to all purported electron carriers in the chain (i.e. E-FAD, ubiquinone-10, and cytochrome b559).	p-chloromercuribenzoate	44-67	mitochondrially encoded cytochrome b	Homo sapiens	188-200
6497852-7	1984	Three different additives, quinacrine, p-chloromercuribenzoate and cetyltrimethylammonium bromide, strongly inhibited O2.- generation; they also inhibited the reduction by NADPH of cytochrome b at the same low concentrations.	p-chloromercuribenzoate	39-62	cytochrome b	Sus scrofa	181-193
7337689-3	1981	Esterase-16 is strongly inhibited by 10(-3) M p-chloromercuribenzoate, but not by 2.	p-chloromercuribenzoate	46-69	esterase 16	Mus musculus	0-11
6850416-5	1983	The ferrochelatase activity is inhibited by divalent copper, mercury, and lead ions and the sodium salt of p-chloromercuribenzoate and is replaced by zinc chelation activity.	p-chloromercuribenzoate	107-130	ferrochelatase	Rattus norvegicus	4-18
6346282-6	1983	The most potent inhibitors of the LH-RH and neurotensin degrading enzymes in synaptosomes are heavy metal ions (mercury and copper), p-chloromercuribenzoate and 1,10 phenanthroline.	p-chloromercuribenzoate	133-156	gonadotropin releasing hormone 1	Rattus norvegicus	34-39
6346282-6	1983	The most potent inhibitors of the LH-RH and neurotensin degrading enzymes in synaptosomes are heavy metal ions (mercury and copper), p-chloromercuribenzoate and 1,10 phenanthroline.	p-chloromercuribenzoate	133-156	neurotensin	Rattus norvegicus	44-55
7157414-1	1982	Rat liver mitochondria contain an aldehyde dehydrogenase (ALDH, EC 1.2.1.3) with a low Km for acetaldehyde (2 microM) which is susceptible to inhibition by a variety of agents including p-chloromercuribenzoate and arsenite.	p-chloromercuribenzoate	186-209	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	34-56
7157414-1	1982	Rat liver mitochondria contain an aldehyde dehydrogenase (ALDH, EC 1.2.1.3) with a low Km for acetaldehyde (2 microM) which is susceptible to inhibition by a variety of agents including p-chloromercuribenzoate and arsenite.	p-chloromercuribenzoate	186-209	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	58-62
7101478-1	1982	P-chloromercuribenzoate (PCMB) inhibition of the leucyl-t-RNA-synthetase (LeuRS) activity was studied both in the tRNA-aminoacylation and ATP-[32P]-pyrophosphate exchange reactions.	p-chloromercuribenzoate	0-23	leucyl-tRNA synthetase 1	Bos taurus	49-72
7101478-1	1982	P-chloromercuribenzoate (PCMB) inhibition of the leucyl-t-RNA-synthetase (LeuRS) activity was studied both in the tRNA-aminoacylation and ATP-[32P]-pyrophosphate exchange reactions.	p-chloromercuribenzoate	0-23	leucyl-tRNA synthetase 1	Bos taurus	74-79
7055579-1	1982	Although a previously reported analysis of Physarum myosin detected no cysteine residues in the molecule, the myosin ATPase activity was inhibited by p-chloromercuribenzoate.	p-chloromercuribenzoate	150-173	myosin, heavy chain 15	Gallus gallus	52-58
7055579-1	1982	Although a previously reported analysis of Physarum myosin detected no cysteine residues in the molecule, the myosin ATPase activity was inhibited by p-chloromercuribenzoate.	p-chloromercuribenzoate	150-173	myosin, heavy chain 15	Gallus gallus	110-116
6105878-8	1980	By means of histochemical activity staining in acrylamide gels it was shown that the purified ATPase preparation could be inhibited by Cd2+ and Zn2+ salts, p-chloromercuribenzoate and N-ethylmaleimide, known inhibitors of membrane endocytosis.	p-chloromercuribenzoate	156-179	dynein axonemal heavy chain 8	Homo sapiens	94-100
6783644-3	1981	Significant phospholipase A2 activity was detectable only if the reutilization of liberated fatty acid was inhibited , e.g. by p-chloromercuribenzoate.	p-chloromercuribenzoate	127-150	phospholipase A2 group IB	Homo sapiens	12-28
6262880-5	1981	The protease inhibitors puromycin and bacitracin, the metal chelator 1,10-phenanthroline, and the sulphydryl blocking agents N-ethylmaleimide and p-chloromercuribenzoate greatly reduced the release of tryptophan from CCK-8.	p-chloromercuribenzoate	146-169	cholecystokinin	Rattus norvegicus	217-220
16661614-11	1981	AgNO(3) (0.1 millimolar) and p-chloromercuribenzoate (1.0 millimolar) completely inhibited the enzyme.Aldose-6-phosphate reductase activity was also detected in mature leaves from Golden Delicious and Antonovka apples (Malus domestica), Conference and Bartlett pears (Pyrus communis), Redhaven peach (Prunus persica), and Perfection apricot (Prunus armeniaca).	p-chloromercuribenzoate	29-52	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	102-130
422533-6	1979	Latent activity of glucose dehydrogenase in intact microsomes could be detected by using inhibitors of microsomal electron transport, i.e. carbon monoxide and p-chloromercuribenzoate (PCMB), and under anaerobic conditions.	p-chloromercuribenzoate	159-182	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	19-40
94652-7	1979	The protease activity was inhibited by 5 X 10(-3) M p-chloromercuribenzoate and by phenylmethyl sulfonyl fluoride, TPCK, and soybean trypsin inhibitor, therefore the enzymatic activity probably depends on a serine residue and a sulfhydryl group.	p-chloromercuribenzoate	52-75	kunitz trypsin protease inhibitor	Glycine max	133-150
36318-0	1979	Effect of leucine on the pyridine nucleotide contents of islets and on the insulin released--interactions in vitro with methylene blue, thiol oxidants, and p-chloromercuribenzoate.	p-chloromercuribenzoate	156-179	insulin	Homo sapiens	75-82
36318-5	1979	Employing the perfused pancreas technique, the insulin-releasing action of p-chloromercuribenzoate was further enhanced by leucine.	p-chloromercuribenzoate	75-98	insulin	Homo sapiens	47-54
41579-11	1979	Zn2+, Mn2+, heparin, glutathione and p-chloromercuribenzoate inhibit the ribonuclease, while Na+, K+, EDTA and sermidine have only little or no effect.	p-chloromercuribenzoate	37-60	ribonuclease	Saccharomyces cerevisiae S288C	73-85
701262-3	1978	The intermediate hemoglobin was isolated by CM Sephadex C-50 column chromatography and identified as alpha3+beta2+ valency hybrid by studies using the pattern of isoelectric focusing of p-chloromercuribenzoate-treated intermediate hemoglobin on Ampholine plate gel, absorption spectra, and difference spectra induced by the addition of inositol hexaphosphate in comparison with the reconstituted valency hybrids, alpha3+beta2+ and alpha2+beta3+.	p-chloromercuribenzoate	186-209	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	101-113
701262-3	1978	The intermediate hemoglobin was isolated by CM Sephadex C-50 column chromatography and identified as alpha3+beta2+ valency hybrid by studies using the pattern of isoelectric focusing of p-chloromercuribenzoate-treated intermediate hemoglobin on Ampholine plate gel, absorption spectra, and difference spectra induced by the addition of inositol hexaphosphate in comparison with the reconstituted valency hybrids, alpha3+beta2+ and alpha2+beta3+.	p-chloromercuribenzoate	186-209	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	413-425
701262-3	1978	The intermediate hemoglobin was isolated by CM Sephadex C-50 column chromatography and identified as alpha3+beta2+ valency hybrid by studies using the pattern of isoelectric focusing of p-chloromercuribenzoate-treated intermediate hemoglobin on Ampholine plate gel, absorption spectra, and difference spectra induced by the addition of inositol hexaphosphate in comparison with the reconstituted valency hybrids, alpha3+beta2+ and alpha2+beta3+.	p-chloromercuribenzoate	186-209	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	431-443
27248-2	1978	p-Chloromercuribenzoate (p-CMB) is found to inhibit glutamine synthetase activity, the degree of inhibition depending on the inhibitor concentration.	p-chloromercuribenzoate	0-23	glutamate-ammonia ligase	Homo sapiens	52-72
411509-10	1977	The soluble lactase and alkaline phosphatase were inhibited minimally by p-chloromercuribenzoate, and sodium fluoride respectively.	p-chloromercuribenzoate	73-96	lactase	Rattus norvegicus	12-19
32715-6	1978	In polyribosomes RNase occurred in both free and p-chloromercuribenzoate (pCMB)-liberated forms.	p-chloromercuribenzoate	49-72	ribonuclease	Saccharomyces cerevisiae S288C	17-22
306780-4	1978	Leupeptin and p-chloromercuribenzoate inhibited both cathepsin B and collagenolytic cathepsin in the ciliary body lysosomes.	p-chloromercuribenzoate	14-37	cathepsin B	Bos taurus	53-64
10611-6	1976	The aminopeptidase activity of the hemolysate made free of membranes could be inhibited by diisopropylfluorphosphate and p-chloromercuribenzoate at three different pH-values (pH 5,0; 6,5; 7,0; 8,0 and 6,5; 7,0; 8,0 respectively).	p-chloromercuribenzoate	121-144	carboxypeptidase Q	Homo sapiens	4-18
840323-5	1977	The partially purified demethylase, which is stable for 3-5 days at -5 degrees C in the presence of dithiothreitol and glutathione and is inhibited by p-chloromercuribenzoate, has maximal activity at pH between 7.2 and 8.0.	p-chloromercuribenzoate	151-174	methyl-CpG binding domain protein 2	Homo sapiens	23-34
1261554-4	1976	Modification of 8 -SH groups per mole of glyceraldehyde-3-phosphate dehydrogenase with p-chloromercuribenzoate results in no alterations in the quantitative precipitin curve, thus supporting the conclusion about the different localization of species-specific antigenic determinants of the enzyme and its active center.	p-chloromercuribenzoate	87-110	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	41-81
818137-8	1976	The bovine pancreatic lipase appeared to contain sulfhydryl groups which may be essential for the lipolytic activity since p-chloromercuribenzoate, N-ethylmaleimide, sodium arsenite, and iodoacetate inhibited the enzyme.	p-chloromercuribenzoate	123-146	pancreatic lipase	Bos taurus	11-28
4374194-6	1974	The stimulation of growth-hormone release by p-chloromercuribenzoate was not potentiated by 3-isobutyl-1-methylxanthine.	p-chloromercuribenzoate	45-68	growth hormone 1	Homo sapiens	19-33
235300-4	1975	p-Chloromercuribenzoate at 50 muM, which gave almost complete inhibition of the NADH-cytochrome c reductase fraction of the maize nitrate reductase, had no marked effect on the action of the inactivating enzyme.	p-chloromercuribenzoate	0-23	nitrate reductase [NADH] 1	Zea mays	130-147
5117032-9	1971	The properties of the different forms of the acid beta-galactosidase were studied with regard to pH optimum, K(m), rate of hydrolysis of different substrates, and sensitivity to p-chloromercuribenzoate and tris as inhibitors.	p-chloromercuribenzoate	178-201	galactosidase beta 1	Homo sapiens	50-68
4412067-0	1974	Apparent conversion of placental cytochrome P-420 to P-450 with p-chloromercuribenzoate.	p-chloromercuribenzoate	64-87	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	53-58
4272320-0	1973	Removal of one g2-subunit from the myosin molecule by p-chloromercuribenzoate-treatment.	p-chloromercuribenzoate	54-77	myosin heavy chain 14	Homo sapiens	35-41
4388687-20	1968	The dehydrogenase is inhibited by semicarbazide (K(i) 3.35mum), isoniazid (K(i) 1.17mum), cuprizone (K(i) 0.49mum), p-chloromercuribenzoate (K(i) 0.45mm) and quinacrine (K(i) 12.1mm).	p-chloromercuribenzoate	116-139	MEXAM1_RS21720	Methylobacterium extorquens AM1	4-17
25172888-10	2014	Butyrate transport is significantly inhibited by p-chloromercuribenzoate, phloretin and alpha-cyano-4-hydroxycinnamic acid, all potent inhibitors of MCT1.	p-chloromercuribenzoate	49-72	solute carrier family 16 member 1	Equus caballus	149-153
5840677-0	1965	Absorption of bis(dinitrophenyl)lysine by myosin after treatment with p-chloromercuribenzoate.	p-chloromercuribenzoate	70-93	myosin heavy chain 14	Homo sapiens	42-48
14367777-13	1955	The sulfhydryl poison, p-chloromercuribenzoate, blocks the synthesis of iodopsin, as of rhodopsin.	p-chloromercuribenzoate	23-46	opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)	Gallus gallus	72-80
14367777-13	1955	The sulfhydryl poison, p-chloromercuribenzoate, blocks the synthesis of iodopsin, as of rhodopsin.	p-chloromercuribenzoate	23-46	rhodopsin	Gallus gallus	88-97
5688928-8	1968	A small amount of added Mg(2+), Mn(2+) or Ca(2+) was required for maximum adenosine kinase activity after cation bound to the enzyme had been released by treatment with p-chloromercuribenzoate and then removed by dialysis.	p-chloromercuribenzoate	169-192	adenosine kinase	Homo sapiens	74-90
4382012-6	1966	The properties of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were studied with respect to K(m) values for substrates and NADP(+), pH optima and the effects of p-chloromercuribenzoate and palmitoyl-CoA.	p-chloromercuribenzoate	187-210	glucose-6-phosphate dehydrogenase	Rattus norvegicus	18-51
14015599-0	1963	[Hemolytic action "in vitro" of p-chloromercuribenzoate on erythrocytes deficient in glucose-6-phosphate dehydrogenase].	p-chloromercuribenzoate	32-55	glucose-6-phosphate dehydrogenase	Homo sapiens	85-118
13705428-0	1961	The binding of p-chloromercuribenzoate by myosin.	p-chloromercuribenzoate	15-38	myosin heavy chain 14	Homo sapiens	42-48
14955620-2	1952	The synthesis of rhodopsin, though unaffected by the less powerful sulfhydryl reagents, monoiodoacetic acid and its amide, is inhibited completely by p-chloromercuribenzoate (PCMB).	p-chloromercuribenzoate	150-173	rhodopsin	Bos taurus	17-26
16935571-1	2007	The passage of water through the aquaporin-1 (AQP1) transmembrane channel protein of the human erythrocyte is known to be inhibited by organic mercurials such as p-chloromercuribenzoate (pCMB), which react with the free SH-group of the critical cysteine (Cys189) located near the constriction of the AQP1 water-specific channel.	p-chloromercuribenzoate	162-185	aquaporin 1 (Colton blood group)	Homo sapiens	33-44
23123479-1	2012	Recently, we have found that pressure-induced hemolysis is enhanced by inhibiting water transport via aquaporin-1 (AQP1), as seen in p-chloromercuribenzoate (pCMB)-treated erythrocytes.	p-chloromercuribenzoate	133-156	aquaporin 1 (Colton blood group)	Homo sapiens	102-113
23123479-1	2012	Recently, we have found that pressure-induced hemolysis is enhanced by inhibiting water transport via aquaporin-1 (AQP1), as seen in p-chloromercuribenzoate (pCMB)-treated erythrocytes.	p-chloromercuribenzoate	133-156	aquaporin 1 (Colton blood group)	Homo sapiens	115-119
16935571-1	2007	The passage of water through the aquaporin-1 (AQP1) transmembrane channel protein of the human erythrocyte is known to be inhibited by organic mercurials such as p-chloromercuribenzoate (pCMB), which react with the free SH-group of the critical cysteine (Cys189) located near the constriction of the AQP1 water-specific channel.	p-chloromercuribenzoate	162-185	aquaporin 1 (Colton blood group)	Homo sapiens	46-50
16935571-1	2007	The passage of water through the aquaporin-1 (AQP1) transmembrane channel protein of the human erythrocyte is known to be inhibited by organic mercurials such as p-chloromercuribenzoate (pCMB), which react with the free SH-group of the critical cysteine (Cys189) located near the constriction of the AQP1 water-specific channel.	p-chloromercuribenzoate	162-185	aquaporin 1 (Colton blood group)	Homo sapiens	300-304
8961169-4	1996	In both colon and ileum, cytosolic insulin-degrading activities had a pH optimum at pH 7.5, and were extensively inhibited by each of N-ethylmaleimide, p-chloromercuribenzoate, and 1,10-phenanthroline, but were very weakly affected by each of leupeptin, chymostatin, diisopropyl phosphofluoridate and soybean trypsin inhibitor.	p-chloromercuribenzoate	152-175	insulin	Homo sapiens	35-42
17306233-3	2007	This study focused on the effects of a protease inhibitor, p-chloromercuribenzoate (PCMB), on the binding of (125)I-Ang II to rat brain membranes.	p-chloromercuribenzoate	59-82	angiotensinogen	Rattus norvegicus	116-122
15096051-7	2004	ER-60-stimulated apoB100 degradation and inhibition of apoB100 secretion were sensitive to the protease inhibitor, p-chloromercuribenzoate (pCMB), in a dose-dependent manner but were unaffected by the proteasomal or lysosomal protease inhibitors, N-acetyl-leucinyl-leucinyl-nor-leucinal, E64, and leupeptin.	p-chloromercuribenzoate	115-138	protein disulfide isomerase family A member 3	Homo sapiens	0-5
15096051-7	2004	ER-60-stimulated apoB100 degradation and inhibition of apoB100 secretion were sensitive to the protease inhibitor, p-chloromercuribenzoate (pCMB), in a dose-dependent manner but were unaffected by the proteasomal or lysosomal protease inhibitors, N-acetyl-leucinyl-leucinyl-nor-leucinal, E64, and leupeptin.	p-chloromercuribenzoate	115-138	apolipoprotein B	Homo sapiens	17-24
15096051-7	2004	ER-60-stimulated apoB100 degradation and inhibition of apoB100 secretion were sensitive to the protease inhibitor, p-chloromercuribenzoate (pCMB), in a dose-dependent manner but were unaffected by the proteasomal or lysosomal protease inhibitors, N-acetyl-leucinyl-leucinyl-nor-leucinal, E64, and leupeptin.	p-chloromercuribenzoate	115-138	apolipoprotein B	Homo sapiens	55-62
12195287-3	2002	After addition of p-chloromercuribenzoate, a b(5)R inhibitor, the activity of b(5)R in GD and normal thyroid decreased by 85%, the level of H2O2 decreased by 50%, and protein-bound iodine (PBI) formation by 52%.	p-chloromercuribenzoate	18-41	cytochrome b5 reductase 3	Homo sapiens	45-50
12195287-3	2002	After addition of p-chloromercuribenzoate, a b(5)R inhibitor, the activity of b(5)R in GD and normal thyroid decreased by 85%, the level of H2O2 decreased by 50%, and protein-bound iodine (PBI) formation by 52%.	p-chloromercuribenzoate	18-41	cytochrome b5 reductase 3	Homo sapiens	78-83
11764983-0	2001	Modulation influence of p-chloromercuribenzoate on plasma membrane Na+-Ca2+ exchanger of the secretory cells of chironomus larvae salivary gland.	p-chloromercuribenzoate	24-47	nascent polypeptide associated complex subunit alpha 2	Homo sapiens	67-74
10451024-6	1999	GST-AA-NAT enzyme activity is also inhibited by reagents that are known biochemically to modify thiol groups (N-ethylmaleimide, NEM) and histidine residues (p-chloromercuribenzoate, NBS and diethyl pyrocarbonate, DEPC), suggesting the presence of essential cysteine and histidine moieties.	p-chloromercuribenzoate	157-180	aralkylamine N-acetyltransferase	Rattus norvegicus	4-10
12054646-7	2002	PP2A activity was also inhibited by N-ethylmaleimide, iodoacetamide, and p-chloromercuribenzoate.	p-chloromercuribenzoate	73-96	protein phosphatase 2 phosphatase activator	Homo sapiens	0-4
11901211-7	2002	Yeast strains transformed with the CDC34 gene were resistant not only to methylmercury but also to mercuric chloride and p-chloromercuribenzoate.	p-chloromercuribenzoate	121-144	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	35-40
11866527-4	2002	The native cysteine residues C140 and C316 were then selectively labelled with mercury using the sulphydryl-specific reagent p-chloromercuribenzoate (1.6-2.1 mol Hg per mol rhodopsin).	p-chloromercuribenzoate	125-148	rhodopsin	Homo sapiens	173-182
9003420-4	1997	Preincubation with thiol reagents such as p-chloromercuribenzoate, N-ethylmaleimide, iodoacetate and 5,5"-dithiobis-(2-nitrobenzoate) resulted in significant inhibition of recombinant human glutathione synthase.	p-chloromercuribenzoate	42-65	glutathione synthetase	Homo sapiens	190-210
8951616-2	1996	Serum DPPIV, a serine enzyme with an apparent mass of 250 kDa, consists of two identical subunits with an apparent mass of 100 kDa and is inhibited by DPPIV-specific inhibitor Diprotin A and also by p-chloromercuribenzoate (p-CMB), 2-mercaptoethanol, HgCl2, CdCl2, SrCl2, and ZnCl2.	p-chloromercuribenzoate	199-222	dipeptidyl peptidase 4	Homo sapiens	6-11
8804571-4	1996	While several nonproteolytic reagents were tested, only the heavy metal Hg(II) and p-chloromercuribenzoate (PCMB) were able to induce activation of progelatinase A and resulted in the conversion of the latent 72-kDa gelatinase A to an active form of about 64.5 kDa.	p-chloromercuribenzoate	83-106	matrix metallopeptidase 2	Homo sapiens	148-163
7494830-5	1995	Cytosolic insulin-degrading activity had a pH optimum of 7.5, was almost completely inhibited by IDE inhibitors (N-ethylmaleimide, 1,10-phenanthroline, EDTA, p-chloromercuribenzoate, bacitracin), but was not or only weakly inhibited by others (aprotinin, chymostatin, leupeptin, and diisopropyl phosphofluoridate.)	p-chloromercuribenzoate	158-181	insulin	Homo sapiens	10-17
7494830-5	1995	Cytosolic insulin-degrading activity had a pH optimum of 7.5, was almost completely inhibited by IDE inhibitors (N-ethylmaleimide, 1,10-phenanthroline, EDTA, p-chloromercuribenzoate, bacitracin), but was not or only weakly inhibited by others (aprotinin, chymostatin, leupeptin, and diisopropyl phosphofluoridate.)	p-chloromercuribenzoate	158-181	insulin degrading enzyme	Homo sapiens	97-100
8311248-3	1993	The rates of reaction of five mercaptide-forming reagents with SHs in OVA were in the order ethylmercuric chloride > mersalyl acid > p-chloromercuribenzoate > p-(chloromercuri)benzenesulfonic acid > fluorescein mercuric acetate.	p-chloromercuribenzoate	139-162	ovalbumin (SERPINB14)	Gallus gallus	70-73
1318696-2	1992	The purified enzyme was spin labeled by a nitroxide derivative of p-chloromercuribenzoate.	p-chloromercuribenzoate	66-89	spindlin 1	Rattus norvegicus	24-28
1311586-3	1992	The steady state concentration of this radical was not decreased by CO or SKF 525-A (two inhibitors of cytochrome P450), but was decreased by NADP+ (10 mM) or p-chloromercuribenzoate (0.47 mM) (two inhibitors of NADPH-cytochrome P450 reductase activity).	p-chloromercuribenzoate	159-182	cytochrome p450 oxidoreductase	Rattus norvegicus	212-243
27286381-6	1992	The activity of the enzyme was completely inhibited by p-chloromercuribenzoate, and the enzyme is estimated to be an aldose reductase.	p-chloromercuribenzoate	55-78	aldo-keto reductase family 1 member B	Homo sapiens	117-133
1851835-2	1991	The steady-state concentration of the nitro anion free radical was not decreased by SKF 525-A, carbon monoxide or metyrapone (3 inhibitors of cytochrome P-450) but was decreased by NADP+ or p-chloromercuribenzoate (2 inhibitors of NADPH-cytochrome P-450 reductase).	p-chloromercuribenzoate	190-213	cytochrome p450 oxidoreductase	Rattus norvegicus	231-263