PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34153873-7	2021	The "KAG" motif, corresponding to HLA-DRB1x04:01, was most strongly associated with T1D risk ((O)dds (R)atio=3.64, p = 3.19 x 10-64).	Fumigant 93	97-100	major histocompatibility complex, class II, DR beta 1	Homo sapiens	34-42
34130073-13	2021	CONCLUSION: This study suggests that the TCM formula DBD effectively serves as a potential therapeutic agent for prevention of DD through regulatory effects on the CREB/BDNF/TrkB pathway to protect and remodel hippocampal neurons.	Fumigant 93	127-129	cAMP responsive element binding protein 1	Rattus norvegicus	164-168
34130073-13	2021	CONCLUSION: This study suggests that the TCM formula DBD effectively serves as a potential therapeutic agent for prevention of DD through regulatory effects on the CREB/BDNF/TrkB pathway to protect and remodel hippocampal neurons.	Fumigant 93	127-129	brain-derived neurotrophic factor	Rattus norvegicus	169-173
34130073-13	2021	CONCLUSION: This study suggests that the TCM formula DBD effectively serves as a potential therapeutic agent for prevention of DD through regulatory effects on the CREB/BDNF/TrkB pathway to protect and remodel hippocampal neurons.	Fumigant 93	127-129	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	174-178
34198201-9	2021	Application of the DDS framework has identified a key bottleneck in assessing the dynamics of TN - low data accessibility and availability.	Fumigant 93	19-22	C-type lectin domain family 3 member B	Homo sapiens	94-96
34069671-14	2021	However, during DDS-induced intestinal inflammation secretion of TNF-alpha is independent of CD200 expression.	Fumigant 93	16-19	tumor necrosis factor	Mus musculus	65-74
3857912-3	1985	One strain, DD/S, differs from the other three in serum LAP.	Fumigant 93	12-14	torsin A interacting protein 1	Mus musculus	56-59
2452443-4	1988	Moreover, the H-2d mice respond predominantly to a single immunodominant site represented by a 15-residue synthetic peptide conforming to the amphipathic alpha-helix model of T-cell epitopes and seen by CD4- CD8+ CTL in association with the Dd class I major histocompatibility complex (MHC) molecules.	Fumigant 93	241-243	histocompatibility 2, D region	Mus musculus	14-18
3857912-12	1985	The level of serum LAP activity in DD/S is approximately twice that in C57BL/6J.	Fumigant 93	35-37	torsin A interacting protein 1	Mus musculus	19-22
4477565-1	1974	The influence of DDS on PHA-induced lymphocyte transformation was investigated in leukocyte cultures from two samples of healthy Caucasoid individuals.	Fumigant 93	17-20	lamin B receptor	Homo sapiens	24-27
6607512-4	1983	The recognition of the antigens detected by the B10.AM anti-B10.A(1R) CTL is restricted by the Kk and Db molecules, but the CTL also cross-react with the Dd molecule (or a molecule controlled by a locus closely linked to Dd).	Fumigant 93	154-156	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	48-51
6607512-4	1983	The recognition of the antigens detected by the B10.AM anti-B10.A(1R) CTL is restricted by the Kk and Db molecules, but the CTL also cross-react with the Dd molecule (or a molecule controlled by a locus closely linked to Dd).	Fumigant 93	154-156	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	60-63
6607512-4	1983	The recognition of the antigens detected by the B10.AM anti-B10.A(1R) CTL is restricted by the Kk and Db molecules, but the CTL also cross-react with the Dd molecule (or a molecule controlled by a locus closely linked to Dd).	Fumigant 93	221-223	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	48-51
6607512-4	1983	The recognition of the antigens detected by the B10.AM anti-B10.A(1R) CTL is restricted by the Kk and Db molecules, but the CTL also cross-react with the Dd molecule (or a molecule controlled by a locus closely linked to Dd).	Fumigant 93	221-223	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	60-63
1139763-4	1975	In normal subjects (dD/dt/Dt) max averaged 34.2 plus or minus 5.7 sec-1; it was signigicantly lower in patients with congestive cardiomyopathy (26.5 plus or minus 6.3 sec-1 p greater than 0.005).	Fumigant 93	20-22	secretory blood group 1, pseudogene	Homo sapiens	66-71
4477565-3	1974	The frequency of lymphocyte transformation induced by PHA was significantly reduced by DDS in all concentrations used.	Fumigant 93	87-90	lamin B receptor	Homo sapiens	54-57
34017337-8	2021	We performed computational analyses of dapsone and DDS-NHOH interacting with HLA-B*13:01 and HLA-B*13:02 alleles by the molecular docking approach.	Fumigant 93	51-54	major histocompatibility complex, class I, B	Homo sapiens	77-82
33502708-5	2021	The results revealed that the MLR models performed well (RMSE = 0.004 +- 0.0043, R2 = 0.998 +- 0.001, and MAE = 0.002 +- 0.003) for the DD, DCD, and OB.	Fumigant 93	136-138	dermcidin	Homo sapiens	140-143
4554497-0	1972	Microsomal N-oxidation of dapson as a cause of methemoglobin formation in human red cells.	Fumigant 93	26-32	hemoglobin subunit gamma 2	Homo sapiens	47-60
34017337-8	2021	We performed computational analyses of dapsone and DDS-NHOH interacting with HLA-B*13:01 and HLA-B*13:02 alleles by the molecular docking approach.	Fumigant 93	51-54	major histocompatibility complex, class I, B	Homo sapiens	93-98
31541772-4	2019	Trilliumoside D showed significant cytotoxicity against MOLT-4 cell lines with an IC50 value of 1.0 +- 0.1 muM, whereas trilliumosides H and I displayed remarkable anti-inflammatory effects on NO production with inhibitory rates of 56.3 +- 1.5 and 56.2 +- 2.2% at the concentration of 1.0 muM, respectively.	Fumigant 93	0-15	latexin	Homo sapiens	107-110
32952671-2	2020	Herein, we report a novel dihydroartemisinin (DHA)-decorating nano-DDS that in situ specifically recruits endogenous apolipoprotein E (apoE) on the NPs surface.	Fumigant 93	67-70	apolipoprotein E	Homo sapiens	117-133
32952671-2	2020	Herein, we report a novel dihydroartemisinin (DHA)-decorating nano-DDS that in situ specifically recruits endogenous apolipoprotein E (apoE) on the NPs surface.	Fumigant 93	67-70	apolipoprotein E	Homo sapiens	135-139
31778580-5	2020	Catalpol, aucubin, and rehmannioside D may be substrates of BCRP and MRP2, rehmannioside A and rhein may be substrates of BCRP, and acteoside and chrysophanol may be substrates of P-gp, BCRP and MRP2.	Fumigant 93	23-38	BCR pseudogene 1	Homo sapiens	60-64
31493688-10	2019	In DD, ASB-BAT and ASB-GM had the highest muSBS, statistically different from ASB-CHX.	Fumigant 93	3-5	arylsulfatase B	Homo sapiens	19-22
31493688-10	2019	In DD, ASB-BAT and ASB-GM had the highest muSBS, statistically different from ASB-CHX.	Fumigant 93	3-5	arylsulfatase B	Homo sapiens	19-22
31493688-12	2019	In DD, ASB-GM reached the highest value, which was statistically different from CONTROL and ASB-CHX.	Fumigant 93	3-5	arylsulfatase B	Homo sapiens	7-10
32807227-9	2020	RESULTS: Compared to controls, mean CSF NPTX2 levels were lower in DS at all AD stages; aDS (0.6-fold, adj.p < 0.0001), pDS (0.5-fold, adj.p < 0.0001) and dDS (0.3-fold, adj.p < 0.0001).	Fumigant 93	155-158	neuronal pentraxin 2	Homo sapiens	40-45
31778580-5	2020	Catalpol, aucubin, and rehmannioside D may be substrates of BCRP and MRP2, rehmannioside A and rhein may be substrates of BCRP, and acteoside and chrysophanol may be substrates of P-gp, BCRP and MRP2.	Fumigant 93	23-38	ATP binding cassette subfamily C member 2	Homo sapiens	69-73
30979585-3	2019	NleB adopts a GT-A fold with a unique helix-pair insertion to hold FADD-DD; the interface contacts explain the selectivity of NleB for certain DDs.	Fumigant 93	143-146	Fas (TNFRSF6)-associated via death domain	Mus musculus	67-71
31742049-11	2019	DNA extraction was done for tumor proper and surgical margin tissue and PCR analysis was carried for p16 microsatellite marker (D91747).	Fumigant 93	128-134	cyclin dependent kinase inhibitor 2A	Homo sapiens	101-104
31407579-2	2019	The reaction happens through an uncommon Michael reaction between aromatic derivatives as aromatic C(sp2)-H nucleophiles and DDs as acceptors.	Fumigant 93	125-128	Sp2 transcription factor	Homo sapiens	99-104
31281399-13	2019	In addition, hippocampal expression levels of caspase-3 and mGluR2/3 were significantly higher, ERK expression was lower, and Glu was elevated in the DD group.	Fumigant 93	150-152	caspase 3	Rattus norvegicus	46-55
31281399-13	2019	In addition, hippocampal expression levels of caspase-3 and mGluR2/3 were significantly higher, ERK expression was lower, and Glu was elevated in the DD group.	Fumigant 93	150-152	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	60-66
31281399-13	2019	In addition, hippocampal expression levels of caspase-3 and mGluR2/3 were significantly higher, ERK expression was lower, and Glu was elevated in the DD group.	Fumigant 93	150-152	Eph receptor B1	Rattus norvegicus	96-99
29045131-9	2017	DDS and DDS-NO-specific clones secreted a mixture of Th1 and Th2 cytokines, but not granzyme-B.	Fumigant 93	0-3	negative elongation factor complex member C/D	Homo sapiens	53-56
30892599-5	2019	Emergence data collected from pupae exposed to 10 constant temperatures was used to estimate the LDT and DDs required to complete pupal development for the three populations.	Fumigant 93	105-108	Partner of Bursicon	Drosophila melanogaster	130-135
30216448-7	2018	Furthermore, L. reuteri F-9-35 protected the mice from gut microbiota dysbiosis from DDS induced colitis.	Fumigant 93	85-88	coagulation factor IX	Mus musculus	24-27
29288856-1	2018	OBJECTIVE: To investigate risk factors and outcomes and to develop a cogent perioperative management algorithm for dural defects (DDs) in anterior surgery for cervical ossification of the posterior longitudinal ligament (OPLL).	Fumigant 93	130-133	OPLL	Homo sapiens	221-225
29247909-6	2018	LPS of strain PJ1 HP1284:cam was missing dd-Hep from the core and had beta-GlcNAc attached directly to O-3 of the inner-core ld-Hep residue.	Fumigant 93	41-44	paralysis, JHMV-induced 1	Mus musculus	14-17
30248496-7	2018	(E)-1,3-Dichloropropene (DCP) was used as a model compound of DD.	Fumigant 93	62-64	small nucleolar RNA, H/ACA box 73A	Homo sapiens	0-5
29733646-5	2018	Here, we establish the uninduced background and induction levels for two widely used DDs (FKBP and DHFR) by developing an accurate quantification method.	Fumigant 93	85-88	FK506-binding protein 12kD	Drosophila melanogaster	90-94
29733646-5	2018	Here, we establish the uninduced background and induction levels for two widely used DDs (FKBP and DHFR) by developing an accurate quantification method.	Fumigant 93	85-88	Dihydrofolate reductase	Drosophila melanogaster	99-103
30008595-11	2018	DDS-1 and UALp-05 significantly upregulated anti-inflammatory IL-10 and downregulated pro-inflammatory TNF-alpha cytokine production.	Fumigant 93	0-3	interleukin 10	Homo sapiens	62-67
30008595-11	2018	DDS-1 and UALp-05 significantly upregulated anti-inflammatory IL-10 and downregulated pro-inflammatory TNF-alpha cytokine production.	Fumigant 93	0-3	tumor necrosis factor	Homo sapiens	103-112
29045131-9	2017	DDS and DDS-NO-specific clones secreted a mixture of Th1 and Th2 cytokines, but not granzyme-B.	Fumigant 93	8-11	negative elongation factor complex member C/D	Homo sapiens	53-56
27496082-7	2017	Expression of the fibrotic markers vimentin, fibronectin, and alpha-smooth muscle actin was more elevated in biopsy specimens from DDs at 4 months than in those from LDs.	Fumigant 93	131-134	vimentin	Homo sapiens	35-43
28770521-8	2017	Treating CaCo-2 cells with both free and SMA-Ral improved cell survival after exposure to 2% DDS with significantly higher protection with SMA-Ral.	Fumigant 93	93-96	RAS like proto-oncogene A	Homo sapiens	45-48
27496082-7	2017	Expression of the fibrotic markers vimentin, fibronectin, and alpha-smooth muscle actin was more elevated in biopsy specimens from DDs at 4 months than in those from LDs.	Fumigant 93	131-134	fibronectin 1	Homo sapiens	45-56
27496082-9	2017	Multivariate analysis point to transforming growth factor-beta1 as the best predictor of long-term renal function in DDs.	Fumigant 93	117-120	transforming growth factor beta 1	Homo sapiens	31-63
25931161-9	2015	Finally, both Annexin V and TUNEL-positive cells were significantly reduced by DDS as compared to untreated SCI animals.	Fumigant 93	79-82	annexin A5	Rattus norvegicus	14-23
26873535-0	2016	Introduction to a New Section: "DDS-GRG Mentored Reviews".	Fumigant 93	32-35	TLE family member 5, transcriptional modulator	Homo sapiens	36-39
26284371-6	2015	DDS-NHOH inhibited catalase (CAT) activity and reactive oxygen species (ROS) generation, but did not alter superoxide dismutase (SOD) activity in erythrocytes.	Fumigant 93	0-3	catalase	Homo sapiens	19-27
26284371-6	2015	DDS-NHOH inhibited catalase (CAT) activity and reactive oxygen species (ROS) generation, but did not alter superoxide dismutase (SOD) activity in erythrocytes.	Fumigant 93	0-3	catalase	Homo sapiens	29-32
27591429-6	2016	Results showed that LL- and DD-raised mice exhibited decreased GR expression in the hippocampus, increased plasma corticosterone concentration at the onset of the dark phase and a depressive phenotype when exposed to LD cycles later in life.	Fumigant 93	28-30	nuclear receptor subfamily 3, group C, member 1	Mus musculus	63-65
26689653-2	2016	In this work, we explored Etoricoxib (COX-2 inhibitor)-loaded Poly caprolactone (PCL) microparticles (MPs) as a potential IA-DDS.	Fumigant 93	125-128	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	38-43
26544985-6	2015	Taking into account previous literature, the DDS positively weighted vegetables, fruit, whole cereals, nuts, coffee, low-fat dairy, fiber, PUFA, and alcohol in moderate amounts; while it negatively weighted red meat, processed meats and sugar-sweetened beverages.	Fumigant 93	45-48	pumilio RNA binding family member 3	Homo sapiens	139-143
25515576-8	2014	In individuals with stage I or II FEVR, DD was smaller (1605.34 +- 250.60 vs. 1733.39 +- 163.79 mum), DM was larger (5434.08 +- 824.82 vs. 4696.29 +- 257.34 mum), and DM/DD was higher (3.49 +- 0.93 vs. 2.73 +- 0.28) than those of the controls.	Fumigant 93	40-42	norrin cystine knot growth factor NDP	Homo sapiens	34-38
25528640-4	2015	The DDs assemble into complexes displaying molecular masses in the range 130-158kDa and RAIDD-DD:PIDD-DD stoichiometries of 5:5, 6:5 and 7:5.	Fumigant 93	4-7	CASP2 and RIPK1 domain containing adaptor with death domain	Homo sapiens	88-93
25528640-4	2015	The DDs assemble into complexes displaying molecular masses in the range 130-158kDa and RAIDD-DD:PIDD-DD stoichiometries of 5:5, 6:5 and 7:5.	Fumigant 93	4-7	p53-induced death domain protein 1	Homo sapiens	97-101
25528640-9	2015	Since this characteristic was previously demonstrated for the complex between the DDs of CD95 and FADD, the NMR data for this system are consistent with the formation of a structure homologous to the PIDDosome core.	Fumigant 93	82-85	Fas cell surface death receptor	Homo sapiens	89-93
25528640-9	2015	Since this characteristic was previously demonstrated for the complex between the DDs of CD95 and FADD, the NMR data for this system are consistent with the formation of a structure homologous to the PIDDosome core.	Fumigant 93	82-85	Fas associated via death domain	Homo sapiens	98-102
25515576-8	2014	In individuals with stage I or II FEVR, DD was smaller (1605.34 +- 250.60 vs. 1733.39 +- 163.79 mum), DM was larger (5434.08 +- 824.82 vs. 4696.29 +- 257.34 mum), and DM/DD was higher (3.49 +- 0.93 vs. 2.73 +- 0.28) than those of the controls.	Fumigant 93	170-172	norrin cystine knot growth factor NDP	Homo sapiens	34-38
24361886-6	2014	In addition, we found that the structure-based mutations of TNFR-1 (P367A and P368A), TRADD (F266A), and RIP1 (M637A and R638A) disrupted formation of the death domain (DD) complex and prevented stable interactions among those DDs.	Fumigant 93	227-230	TNF receptor superfamily member 1A	Homo sapiens	60-66
25011070-7	2014	RESULTS: Plasma NGAL levels were significantly lower in LDs than in DDs.	Fumigant 93	68-71	lipocalin 2	Homo sapiens	16-20
24361886-6	2014	In addition, we found that the structure-based mutations of TNFR-1 (P367A and P368A), TRADD (F266A), and RIP1 (M637A and R638A) disrupted formation of the death domain (DD) complex and prevented stable interactions among those DDs.	Fumigant 93	227-230	receptor interacting serine/threonine kinase 1	Homo sapiens	105-109
24427280-12	2014	Hsd11b1 expression in male offspring nursed by cross-fostered dams was higher than that in those nursed by dams fed the same diet; CC vs. CD and DD vs. DC.	Fumigant 93	145-147	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-7
23901245-9	2013	However, for all times studied, rhodopsin was completely dephosphorylated after four days of DD treatment.	Fumigant 93	93-95	rhodopsin	Rattus norvegicus	32-41
23770157-4	2013	Data on DD-treated patients were analyzed by dose and CD25 status.	Fumigant 93	8-10	interleukin 2 receptor subunit alpha	Homo sapiens	54-58
22748424-0	2012	Dapson in heterocyclic chemistry, part VIII: synthesis, molecular docking and anticancer activity of some novel sulfonylbiscompounds carrying biologically active 1,3-dihydropyridine, chromene and chromenopyridine moieties.	Fumigant 93	0-6	cytochrome c oxidase subunit 8A	Homo sapiens	39-43
23922916-4	2013	However, DAPk-DD could be obtained as a soluble protein in the form of a translational fusion protein with the B1 domain of streptococcal protein G. In contrast to other DDs that adopt the canonical six amphipathic alpha-helices arranged in a compact fold, the DAPk-DD was found to possess surprisingly low regular secondary structure content and an absence of a stable globular fold, as determined by circular dichroism (CD), NMR spectroscopy and a temperature-dependent fluorescence assay.	Fumigant 93	170-173	death associated protein kinase 1	Homo sapiens	9-13
23661462-5	2013	The frequencies of ACE genotypes were found to be 47.0% for DD, 30.3% for ID, and 22.7% for II in the COPD group and 32.5% for DD, 47.5% for ID, and 20.0% for II in the control group.	Fumigant 93	60-62	angiotensin I converting enzyme	Homo sapiens	19-22
23582684-10	2013	The findings suggested that the BTB/glioma cells dual-targeting DDS co-administrated with iRGD peptide might provide a both practical and feasible solution to highly efficient anti-glioblastoma drug delivery.	Fumigant 93	64-67	interferon gamma inducible protein 47	Mus musculus	90-94
22411828-5	2012	The high resolution structure of the ankyrin-B ZZUD tandem determined here reveals that the ZU5-ZU5-UPA domains form a tightly packed structural supramodule, whereas DD is freely accessible.	Fumigant 93	166-168	ankyrin 2	Homo sapiens	37-46
23032820-11	2012	S100-P was diffusely positive in WD components (5/7) and focally in DD components (2/9).	Fumigant 93	68-70	S100 calcium binding protein P	Homo sapiens	0-6
22442277-7	2012	Although the decrement in highly sensitive C-reactive protein and fibrinogen was more in CDD compared to DD (-4.0 +- 8.5 vs. -1.3 +- 2.8 mg/liter, and -0.40 +- 0.74 and -0.20 +- 0.52 mg/liter, respectively), the differences were not significant.	Fumigant 93	90-92	fibrinogen beta chain	Homo sapiens	66-76
22442277-8	2012	There was a significant increase in serum adiponectin in both the DD and CDD groups (51.3 +- 65.3 vs. 57.1 +- 33.8 mug/liter; P &lt; 0.05).	Fumigant 93	66-68	adiponectin, C1Q and collagen domain containing	Homo sapiens	42-53
22429337-4	2012	Recently structural information on a ternary complex containing the DDs of MyD88, IRAK4, and IRAK2 and a binary complex containing Fas and FADD DDs has become available.	Fumigant 93	68-71	MYD88 innate immune signal transduction adaptor	Homo sapiens	75-80
22429337-4	2012	Recently structural information on a ternary complex containing the DDs of MyD88, IRAK4, and IRAK2 and a binary complex containing Fas and FADD DDs has become available.	Fumigant 93	68-71	interleukin 1 receptor associated kinase 4	Homo sapiens	82-87
22429337-4	2012	Recently structural information on a ternary complex containing the DDs of MyD88, IRAK4, and IRAK2 and a binary complex containing Fas and FADD DDs has become available.	Fumigant 93	68-71	interleukin 1 receptor associated kinase 2	Homo sapiens	93-98
22429337-4	2012	Recently structural information on a ternary complex containing the DDs of MyD88, IRAK4, and IRAK2 and a binary complex containing Fas and FADD DDs has become available.	Fumigant 93	144-147	Fas associated via death domain	Homo sapiens	139-143
22325199-5	2012	DD remodeling is delayed in hbl-1 mutants whereas precocious remodeling is observed in mutants lacking the microRNA mir-84, which inhibits hbl-1 expression.	Fumigant 93	0-2	Hunchback-like protein	Caenorhabditis elegans	28-33
22737862-8	2012	Pretreated with DD and then intratracheally instillated LPS coulde ameliorat lung tissue injury, reduced PMN BALF number and protein content, but increase HO-1 mRNA and protein expression in the lung tissue when compared with LPS.	Fumigant 93	16-18	heme oxygenase 1	Mus musculus	155-159
22737862-9	2012	HO-1 inhibitor ZnPP coulde inhibite the ameliorative effect of DD.	Fumigant 93	63-65	heme oxygenase 1	Mus musculus	0-4
20485341-2	2010	Here we report the crystal structure of the MyD88-IRAK4-IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88, 4 IRAK4 and 4 IRAK2 DDs.	Fumigant 93	193-196	Myd88	Drosophila melanogaster	44-49
21697358-7	2011	Using pharmacological blockers of the NF-kappaB pathway, we provide evidence that the effects of DD on depression-like behavior, on hippocampal cell proliferation, on altered expressional levels of brain and plasma IL-6, and on the modulation of clock gene expression are mediated through NF-kappaB signaling.	Fumigant 93	97-99	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-47
21697358-9	2011	Mice with a deletion of IL-6, one of the target genes of NF-kappaB, are resistant to DD-induced depression-like behavior, which suggests a pivotal role for this cytokine in the constant darkness mouse model of depression.	Fumigant 93	85-87	interleukin 6	Mus musculus	24-28
21697358-9	2011	Mice with a deletion of IL-6, one of the target genes of NF-kappaB, are resistant to DD-induced depression-like behavior, which suggests a pivotal role for this cytokine in the constant darkness mouse model of depression.	Fumigant 93	85-87	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
20830509-8	2011	Treatment with captopril significantly (P = 0.045) reduced the serum ACE activity in normoalbuminuric patients with DD genotype compared to macroalbuminuric patients with the same genotype (33.6 vs. 73.8 IU/l).	Fumigant 93	116-118	angiotensin I converting enzyme	Homo sapiens	69-72
19916832-11	2009	However, the number of cells expressing cFos in the vSPVZ was positively correlated with general activity during the subjective day relative to the subjective night when the animals were switched to DD, and this pattern persisted when a LD cycle was reinstated.	Fumigant 93	199-201	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	40-44
20150281-6	2010	Our findings suggest that Syntabulin regulates the microtubule-dependent transport of the DDs, and provide evidence for the link between AV and dorsoventral axis formation.	Fumigant 93	90-93	syntabulin (syntaxin-interacting)	Danio rerio	26-36
19952519-10	2009	We anticipate that the elucidation of the ABC phenomenon will be helpful for the development of DDS formulations.	Fumigant 93	96-99	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	42-45
19652499-8	2009	In this review, we will describe DDS-based technology for creating functional mutants for advanced medical applications, using tumor necrosis factor-alpha (TNF) as an example.	Fumigant 93	33-36	tumor necrosis factor	Homo sapiens	127-154
19652499-8	2009	In this review, we will describe DDS-based technology for creating functional mutants for advanced medical applications, using tumor necrosis factor-alpha (TNF) as an example.	Fumigant 93	33-36	tumor necrosis factor	Homo sapiens	156-159
19546528-7	2009	The simultaneous presence of the DD and GG variants of the ACE and eNOS genes was related to an unfavorable outcome as compared with other combinations [hazard ratio ranging from 4.7 (95% CI 1.52-14.33) to 8.4 (95% CI 2.45-29.10)] after controlling for proteinuria, mean arterial pressure and baseline histological lesions.	Fumigant 93	33-35	angiotensin I converting enzyme	Homo sapiens	59-62
19546528-7	2009	The simultaneous presence of the DD and GG variants of the ACE and eNOS genes was related to an unfavorable outcome as compared with other combinations [hazard ratio ranging from 4.7 (95% CI 1.52-14.33) to 8.4 (95% CI 2.45-29.10)] after controlling for proteinuria, mean arterial pressure and baseline histological lesions.	Fumigant 93	33-35	nitric oxide synthase 3	Homo sapiens	67-71
18327080-5	2008	C-domain-selective concentrations of quinaprilat fully blocked angiotensin I-II conversion in DDs, whereas additional N-domain blockade was required to fully block conversion in IIs.	Fumigant 93	94-97	angiotensinogen	Homo sapiens	63-76
18378310-9	2008	In comparison with other techniques, the results of the current study have shown that SRC-DDS is an excellent tool to classify and characterize soils according to the associated risk.	Fumigant 93	90-93	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	86-89
18029065-6	2007	Periplakin, F-box protein 30 and calpain detected only in group DDS have been approved to contribute to the immunopotentiation effect by this vaccination regime, which might be established as an surrogate marker of successful vaccination and provides research target for molecular mechanism of vaccinology.	Fumigant 93	64-67	F-box protein 30	Mus musculus	12-28
17644325-11	2007	As the %DD increased, the CPT-loaded micelles stability increased.	Fumigant 93	8-10	choline phosphotransferase 1	Homo sapiens	26-29
19727356-8	2007	All patients received dapson as a lactoperoxidase inhibitor at a dose of 50 mg daily for 8 weeks.	Fumigant 93	22-28	lactoperoxidase	Homo sapiens	34-49
17715309-8	2007	The mean DDs were 6.71 +/- 1.36 mm for R1 and 6.68 +/- 1.41 mm for R2.	Fumigant 93	9-12	cell division cycle associated 7 like	Homo sapiens	39-50
17031492-5	2006	The dominant negative form of FADD containing DD could abolish these RTN3 generated events in the caspase-8 cascade.	Fumigant 93	32-34	reticulon 3	Homo sapiens	69-73
17289572-3	2007	Although RAIDD DD and PIDD DD are monomers, they assemble into a complex that comprises seven RAIDD DDs and five PIDD DDs.	Fumigant 93	100-103	p53-induced death domain protein 1	Homo sapiens	22-26
17088293-8	2006	Ectopic expression of DDS in a yeast mutant (erg7) lacking lanosterol synthase resulted in the production of dammarenediol and hydroxydammarenone which were confirmed by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry (LC/APCIMS).	Fumigant 93	22-25	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	45-49
17031492-5	2006	The dominant negative form of FADD containing DD could abolish these RTN3 generated events in the caspase-8 cascade.	Fumigant 93	32-34	caspase 8	Homo sapiens	98-107
16512390-4	2006	The study established a significant correlation between the presence of DD-ACE genotype and development of CAD.	Fumigant 93	72-74	angiotensin I converting enzyme	Homo sapiens	75-78
16597320-4	2006	These DD-containing proteins interacted with Xenopus DR members xDR-M1 and xDR-M2 through their DDs in co-transfected HEK-293T cells.	Fumigant 93	96-99	tumor necrosis factor receptor superfamily member 10b S homeolog	Xenopus laevis	64-70
16597320-4	2006	These DD-containing proteins interacted with Xenopus DR members xDR-M1 and xDR-M2 through their DDs in co-transfected HEK-293T cells.	Fumigant 93	96-99	tumor necrosis factor receptor superfamily member 26	Xenopus laevis	75-81
16572586-8	2006	Conversely, VEGF levels increased in vector control and DDS-LNCaP cells treated with 5 nM R1881.	Fumigant 93	56-59	vascular endothelial growth factor A	Homo sapiens	12-16
16572586-9	2006	Not only do these studies point out the regulatory potential of WT1 for VEGF, but they also indicate an altered function for the mutant DDS isoform.	Fumigant 93	136-139	WT1 transcription factor	Homo sapiens	64-67
16572586-9	2006	Not only do these studies point out the regulatory potential of WT1 for VEGF, but they also indicate an altered function for the mutant DDS isoform.	Fumigant 93	136-139	vascular endothelial growth factor A	Homo sapiens	72-76
17041230-8	2006	Surprisingly, modifications in sustained K(+) currents in eag and Shab mutants increased thresholds for DD induction and GF pathway failure.	Fumigant 93	104-106	ether a go-go	Drosophila melanogaster	58-61
17041230-8	2006	Surprisingly, modifications in sustained K(+) currents in eag and Shab mutants increased thresholds for DD induction and GF pathway failure.	Fumigant 93	104-106	Shaker cognate b	Drosophila melanogaster	66-70
16857727-5	2006	In addition, recombinant FMO1 and FMO3 were able to bioactivate both SMX and DDS, resulting in covalent adduct formation.	Fumigant 93	77-80	flavin containing dimethylaniline monoxygenase 1	Homo sapiens	25-29
16857727-5	2006	In addition, recombinant FMO1 and FMO3 were able to bioactivate both SMX and DDS, resulting in covalent adduct formation.	Fumigant 93	77-80	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	34-38
17142213-7	2006	Patients with the DD allele (group DD) of ACE gene polymorphism had (1) significantly elevated mean 5-y intact parathyroid hormone levels when compared with the non-DD group (P=.009), and (2) significantly elevated oral and intravenous 5-y cumulative doses of vitamin D.	Fumigant 93	18-20	angiotensin I converting enzyme	Homo sapiens	42-45
16454185-4	2006	The practical insulin DDS of PLGA nanosphere is summerized.	Fumigant 93	22-25	insulin	Homo sapiens	14-21
16128377-15	2005	The incidence of hypertension and cardiovascular events, was significantly higher in the ACE-DD (53 cases, 23%) than in the ACE-ID and ACE-II groups (20 and 3 cases, 5.9% and 2.4%, respectively), p = 0.0001.	Fumigant 93	93-95	angiotensin I converting enzyme	Homo sapiens	89-92
16274774-4	2005	Data from 198 women with ACS (63+/-10 years) and 149 controls (62+/-7 years) showed that ACE-DD genotype was more prevalent in women with ACS compared to controls (30% vs. 19%, P&lt;0.05).	Fumigant 93	93-95	angiotensin I converting enzyme	Homo sapiens	89-92
15985519-9	2005	CONCLUSIONS: The conjunction of a reduced expression of UT-B and an increased expression of AQPs in brain cells may bring a new clue to understanding the DDS mechanism.	Fumigant 93	154-157	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	56-60
16104890-6	2005	NK cells from SC of Ly-49A-depleted and B10.D2 SC-injected B10 mice showed enhanced cytotoxicity to Dd-positive targets in vitro.	Fumigant 93	100-102	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	20-26
16104890-6	2005	NK cells from SC of Ly-49A-depleted and B10.D2 SC-injected B10 mice showed enhanced cytotoxicity to Dd-positive targets in vitro.	Fumigant 93	100-102	granzyme C	Mus musculus	40-43
16104890-6	2005	NK cells from SC of Ly-49A-depleted and B10.D2 SC-injected B10 mice showed enhanced cytotoxicity to Dd-positive targets in vitro.	Fumigant 93	100-102	granzyme C	Mus musculus	59-62
16301096-8	2005	The BDNF status was associated with four measures in DDs and three measures in DAs.	Fumigant 93	53-56	brain derived neurotrophic factor	Homo sapiens	4-8
15862605-11	2005	For DDS-N-OH the reduction rate by cytochrome b5, NADH-cytochrome b5 reductase and CYP2D was 1.79 +/- 0.85 nmol DDS/min/mg protein and by cytochrome b5 and NADH-cytochrome b5 reductase 1.25 +/- 0.15 nmol DDS/min/mg protein.	Fumigant 93	4-7	cytochrome b5 type A	Sus scrofa	35-48
15862605-11	2005	For DDS-N-OH the reduction rate by cytochrome b5, NADH-cytochrome b5 reductase and CYP2D was 1.79 +/- 0.85 nmol DDS/min/mg protein and by cytochrome b5 and NADH-cytochrome b5 reductase 1.25 +/- 0.15 nmol DDS/min/mg protein.	Fumigant 93	4-7	cytochrome b5 type A	Sus scrofa	55-68
15862605-11	2005	For DDS-N-OH the reduction rate by cytochrome b5, NADH-cytochrome b5 reductase and CYP2D was 1.79 +/- 0.85 nmol DDS/min/mg protein and by cytochrome b5 and NADH-cytochrome b5 reductase 1.25 +/- 0.15 nmol DDS/min/mg protein.	Fumigant 93	4-7	cytochrome b5 type A	Sus scrofa	55-68
15862605-11	2005	For DDS-N-OH the reduction rate by cytochrome b5, NADH-cytochrome b5 reductase and CYP2D was 1.79 +/- 0.85 nmol DDS/min/mg protein and by cytochrome b5 and NADH-cytochrome b5 reductase 1.25 +/- 0.15 nmol DDS/min/mg protein.	Fumigant 93	4-7	cytochrome b5 type A	Sus scrofa	55-68
15862605-11	2005	For DDS-N-OH the reduction rate by cytochrome b5, NADH-cytochrome b5 reductase and CYP2D was 1.79 +/- 0.85 nmol DDS/min/mg protein and by cytochrome b5 and NADH-cytochrome b5 reductase 1.25 +/- 0.15 nmol DDS/min/mg protein.	Fumigant 93	112-115	cytochrome b5 type A	Sus scrofa	35-48
15862605-11	2005	For DDS-N-OH the reduction rate by cytochrome b5, NADH-cytochrome b5 reductase and CYP2D was 1.79 +/- 0.85 nmol DDS/min/mg protein and by cytochrome b5 and NADH-cytochrome b5 reductase 1.25 +/- 0.15 nmol DDS/min/mg protein.	Fumigant 93	112-115	cytochrome b5 type A	Sus scrofa	55-68
15862605-11	2005	For DDS-N-OH the reduction rate by cytochrome b5, NADH-cytochrome b5 reductase and CYP2D was 1.79 +/- 0.85 nmol DDS/min/mg protein and by cytochrome b5 and NADH-cytochrome b5 reductase 1.25 +/- 0.15 nmol DDS/min/mg protein.	Fumigant 93	112-115	cytochrome b5 type A	Sus scrofa	55-68
15862605-11	2005	For DDS-N-OH the reduction rate by cytochrome b5, NADH-cytochrome b5 reductase and CYP2D was 1.79 +/- 0.85 nmol DDS/min/mg protein and by cytochrome b5 and NADH-cytochrome b5 reductase 1.25 +/- 0.15 nmol DDS/min/mg protein.	Fumigant 93	112-115	cytochrome b5 type A	Sus scrofa	55-68
15699351-6	2005	The Spin peptide, when complexed with Dd, also activated the T cell.	Fumigant 93	38-40	spindlin 1	Mus musculus	4-8
15719143-7	2005	(2) In comparison with DD regime, the amplitudes and the mRNA levels at peaks of Clock and NAT genes expressions in LD in the pineal gland were significantly reduced (P&lt; 0.05).	Fumigant 93	23-25	clock circadian regulator	Rattus norvegicus	81-86
15719143-7	2005	(2) In comparison with DD regime, the amplitudes and the mRNA levels at peaks of Clock and NAT genes expressions in LD in the pineal gland were significantly reduced (P&lt; 0.05).	Fumigant 93	23-25	N-acetyltransferase 1	Rattus norvegicus	91-94
15017542-6	2004	RESULTS: In controls, ACE genotype distribution of DD, ID, and II was 11%, 33%, and 55%, respectively, whereas in CDH it was 70%, 15%, and 15%, respectively.	Fumigant 93	51-53	angiotensin I converting enzyme	Homo sapiens	22-25
15383280-4	2004	The extrinsic pathway is disrupted by heterotypic interactions between ARC"s CARD and the DDs of Fas and FADD, which inhibit Fas-FADD binding and assembly of the death-inducing signaling complex (DISC).	Fumigant 93	90-93	Fas associated via death domain	Homo sapiens	129-133
15383280-4	2004	The extrinsic pathway is disrupted by heterotypic interactions between ARC"s CARD and the DDs of Fas and FADD, which inhibit Fas-FADD binding and assembly of the death-inducing signaling complex (DISC).	Fumigant 93	90-93	Fas associated via death domain	Homo sapiens	105-109
15064310-9	2004	The presence of antigens recognized by anti-ubiquitin antibodies in the boar sperm CD, coupled with the possibility that superfluous ubiquitin species are detrimental to embryonic development by targeting critical paternally contributed zygotic organelles, raises concerns that retained DDs may be more detrimental to fertility than previously suspected.	Fumigant 93	287-290	ubiquitin	Bos taurus	44-53
12544512-3	2003	Recently, we found that transcriptional factors, hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha and HNF-4 gamma were essential for the expression of DD4 mRNA, which is a major form of DDs.	Fumigant 93	190-193	hepatocyte nuclear factor 4 alpha	Homo sapiens	90-101
12941445-3	2003	GFAP immunoreactivity in the DD group showed lower levels than those in the LD group at P50.	Fumigant 93	29-31	glial fibrillary acidic protein	Rattus norvegicus	0-4
12544512-3	2003	Recently, we found that transcriptional factors, hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha and HNF-4 gamma were essential for the expression of DD4 mRNA, which is a major form of DDs.	Fumigant 93	190-193	HNF1 homeobox A	Homo sapiens	49-88
12046096-12	2002	DD levels were positively related to vWF levels( r =0.574, P&lt;0.01).	Fumigant 93	0-2	von Willebrand factor	Homo sapiens	37-40
12544512-3	2003	Recently, we found that transcriptional factors, hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha and HNF-4 gamma were essential for the expression of DD4 mRNA, which is a major form of DDs.	Fumigant 93	190-193	hepatocyte nuclear factor 4 gamma	Homo sapiens	106-117
12544512-3	2003	Recently, we found that transcriptional factors, hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha and HNF-4 gamma were essential for the expression of DD4 mRNA, which is a major form of DDs.	Fumigant 93	190-193	aldo-keto reductase family 1 member C4	Homo sapiens	155-158
11896929-3	2002	Here we have focused on an exposed loop in the N-terminal part of the alpha2 domain, which constitutes a major structural motif that differs between Dd (strong binding to Ly49A) and Db (weak binding to Ly49A at best).	Fumigant 93	149-151	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	171-176
11896929-3	2002	Here we have focused on an exposed loop in the N-terminal part of the alpha2 domain, which constitutes a major structural motif that differs between Dd (strong binding to Ly49A) and Db (weak binding to Ly49A at best).	Fumigant 93	149-151	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	202-207
11896929-6	2002	However, the mutation totally abolished the recognition by the conformational dependent monoclonal antibody (MoAb) 34-5-8S, known to inhibit the interaction between Dd and Ly49A.	Fumigant 93	165-167	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	172-177
11453672-5	2001	The strong positive association between concentrations of dioxin-like PCB/DD/DFs and non-dioxin-like PCBs will in future epidemiological studies make it difficult to separate Ah receptor-dependent effects from non-Ah receptor-dependent effects.	Fumigant 93	74-76	pyruvate carboxylase	Homo sapiens	70-73
11453672-5	2001	The strong positive association between concentrations of dioxin-like PCB/DD/DFs and non-dioxin-like PCBs will in future epidemiological studies make it difficult to separate Ah receptor-dependent effects from non-Ah receptor-dependent effects.	Fumigant 93	74-76	aryl hydrocarbon receptor	Homo sapiens	175-186
11453672-5	2001	The strong positive association between concentrations of dioxin-like PCB/DD/DFs and non-dioxin-like PCBs will in future epidemiological studies make it difficult to separate Ah receptor-dependent effects from non-Ah receptor-dependent effects.	Fumigant 93	74-76	aryl hydrocarbon receptor	Homo sapiens	214-225
11090546-0	2000	Probing the interaction between inactivation gating and Dd-sotalol block of HERG.	Fumigant 93	56-58	potassium voltage-gated channel subfamily H member 2	Homo sapiens	76-80
11090546-5	2000	In the present study, we identify a definitive role for inactivation gating in Dd-sotalol block of HERG, using interventions complementary to mutagenesis.	Fumigant 93	79-81	potassium voltage-gated channel subfamily H member 2	Homo sapiens	99-103
10934291-3	2000	The binding of SODD to DD of the TNFR-I maintains DD in monomeric form and prevents their aggregation which is required for the apoptotic signal.	Fumigant 93	17-19	TNF receptor superfamily member 1A	Homo sapiens	33-39
10901692-3	2000	The apparent Michaelis-Menten Km values for DDS-NHY by cloned CYP2C8, CYP2C9, CYP2C18, and CYP2C19 were 75 microM, 31 microM, 25 microM, and greater than 1 mM, respectively.	Fumigant 93	44-47	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	62-68
10901692-4	2000	CYP3A4 and CYP2E1 were incapable of DDS-NHY at 4 microM DDS.	Fumigant 93	36-39	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	11-17
10901692-7	2000	In contrast, S-mephenytoin inhibited DDS-NHY by CYP2C9, CYP2C18, and CYP2C19 by 27 +/- 2, 49 +/- 1, and 32 +/- 4%, respectively.	Fumigant 93	37-40	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	48-54
10901692-7	2000	In contrast, S-mephenytoin inhibited DDS-NHY by CYP2C9, CYP2C18, and CYP2C19 by 27 +/- 2, 49 +/- 1, and 32 +/- 4%, respectively.	Fumigant 93	37-40	cytochrome P450 family 2 subfamily C member 18	Homo sapiens	56-63
10901692-3	2000	The apparent Michaelis-Menten Km values for DDS-NHY by cloned CYP2C8, CYP2C9, CYP2C18, and CYP2C19 were 75 microM, 31 microM, 25 microM, and greater than 1 mM, respectively.	Fumigant 93	44-47	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	70-76
10901692-7	2000	In contrast, S-mephenytoin inhibited DDS-NHY by CYP2C9, CYP2C18, and CYP2C19 by 27 +/- 2, 49 +/- 1, and 32 +/- 4%, respectively.	Fumigant 93	37-40	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	69-76
10901692-8	2000	Because CYP2C18 and CYP19 are expressed at low concentrations in the human liver, these observations indicate that at clinical DDS concentrations, CYP2C9 is a major and CYP2C8 is a likely minor contributor to DDS-NHY in human liver microsomes.	Fumigant 93	127-130	cytochrome P450 family 2 subfamily C member 18	Homo sapiens	8-15
10901692-3	2000	The apparent Michaelis-Menten Km values for DDS-NHY by cloned CYP2C8, CYP2C9, CYP2C18, and CYP2C19 were 75 microM, 31 microM, 25 microM, and greater than 1 mM, respectively.	Fumigant 93	44-47	cytochrome P450 family 2 subfamily C member 18	Homo sapiens	78-85
10901692-8	2000	Because CYP2C18 and CYP19 are expressed at low concentrations in the human liver, these observations indicate that at clinical DDS concentrations, CYP2C9 is a major and CYP2C8 is a likely minor contributor to DDS-NHY in human liver microsomes.	Fumigant 93	127-130	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	20-25
10901692-8	2000	Because CYP2C18 and CYP19 are expressed at low concentrations in the human liver, these observations indicate that at clinical DDS concentrations, CYP2C9 is a major and CYP2C8 is a likely minor contributor to DDS-NHY in human liver microsomes.	Fumigant 93	127-130	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	147-153
10901692-3	2000	The apparent Michaelis-Menten Km values for DDS-NHY by cloned CYP2C8, CYP2C9, CYP2C18, and CYP2C19 were 75 microM, 31 microM, 25 microM, and greater than 1 mM, respectively.	Fumigant 93	44-47	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	91-98
10901692-8	2000	Because CYP2C18 and CYP19 are expressed at low concentrations in the human liver, these observations indicate that at clinical DDS concentrations, CYP2C9 is a major and CYP2C8 is a likely minor contributor to DDS-NHY in human liver microsomes.	Fumigant 93	209-212	cytochrome P450 family 2 subfamily C member 18	Homo sapiens	8-15
10901692-8	2000	Because CYP2C18 and CYP19 are expressed at low concentrations in the human liver, these observations indicate that at clinical DDS concentrations, CYP2C9 is a major and CYP2C8 is a likely minor contributor to DDS-NHY in human liver microsomes.	Fumigant 93	209-212	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	20-25
10901692-4	2000	CYP3A4 and CYP2E1 were incapable of DDS-NHY at 4 microM DDS.	Fumigant 93	36-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
10511770-10	1999	The mean serum ACE activity in the DD group was significantly higher than in the II group (p &lt; 0.05) but was not significantly different from that of the ID group.	Fumigant 93	35-37	angiotensin I converting enzyme	Homo sapiens	15-18
10438920-6	1999	Our functional studies revealed that coexpression of the Dd-specific Ly49A or Ly49G2 inhibitory receptors by Ly49D+ cells resulted in tolerance to Dd+ targets, while coexpression of Kb-specific inhibitory receptors Ly49C/I resulted in tolerance to Kb+ targets.	Fumigant 93	147-150	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	69-74
10438920-6	1999	Our functional studies revealed that coexpression of the Dd-specific Ly49A or Ly49G2 inhibitory receptors by Ly49D+ cells resulted in tolerance to Dd+ targets, while coexpression of Kb-specific inhibitory receptors Ly49C/I resulted in tolerance to Kb+ targets.	Fumigant 93	147-150	killer cell lectin-like receptor, subfamily A, member 7	Mus musculus	78-84
10438920-6	1999	Our functional studies revealed that coexpression of the Dd-specific Ly49A or Ly49G2 inhibitory receptors by Ly49D+ cells resulted in tolerance to Dd+ targets, while coexpression of Kb-specific inhibitory receptors Ly49C/I resulted in tolerance to Kb+ targets.	Fumigant 93	147-150	killer cell lectin-like receptor, subfamily A, member 4	Mus musculus	109-114
10886140-4	2000	In healing wounds and "fibrohistiocytic" tumours, such as dermatofibromas, DDs are often associated with non-dendritic histiocytes, some of which also express factor XIIIa (FXIIIa).	Fumigant 93	75-78	coagulation factor XIII A chain	Homo sapiens	159-171
9409318-12	1997	These results suggest that the increased ACE activity caused by DD polymorphism may play an important role in elevating the level of plasma PAI-1.	Fumigant 93	64-66	angiotensin I converting enzyme	Homo sapiens	41-44
12189317-5	1999	The presence of a DD insertion/deletion pattern for ACE seems to predict an increased level of ACE, possibly increased angiotensin II concentrations, and a relative resistance to the hemodynamic effects of ACE inhibitors.	Fumigant 93	18-20	angiotensin I converting enzyme	Homo sapiens	52-55
12189317-5	1999	The presence of a DD insertion/deletion pattern for ACE seems to predict an increased level of ACE, possibly increased angiotensin II concentrations, and a relative resistance to the hemodynamic effects of ACE inhibitors.	Fumigant 93	18-20	angiotensin I converting enzyme	Homo sapiens	95-98
12189317-5	1999	The presence of a DD insertion/deletion pattern for ACE seems to predict an increased level of ACE, possibly increased angiotensin II concentrations, and a relative resistance to the hemodynamic effects of ACE inhibitors.	Fumigant 93	18-20	angiotensinogen	Homo sapiens	119-133
12189317-5	1999	The presence of a DD insertion/deletion pattern for ACE seems to predict an increased level of ACE, possibly increased angiotensin II concentrations, and a relative resistance to the hemodynamic effects of ACE inhibitors.	Fumigant 93	18-20	angiotensin I converting enzyme	Homo sapiens	95-98
9973410-5	1999	The inability of Dd(E222K) to interact with tapasin and TAP results in impaired peptide loading within the endoplasmic reticulum.	Fumigant 93	17-19	TAP binding protein	Mus musculus	44-51
10197222-4	1998	The serum ACE level with the DD type is reported to be about double that of the II type and intermediate in the DI case.	Fumigant 93	29-31	angiotensin I converting enzyme	Homo sapiens	10-13
9738501-6	1998	In lin-14 loss-of-function mutants, DDs remodel precociously.	Fumigant 93	36-39	Protein lin-14	Caenorhabditis elegans	3-9
9738501-8	1998	Expression of lin-14(+) in the DDs of lin-14-null mutants rescues the precocious remodelling, indicating that lin-14 can act cell-autonomously.	Fumigant 93	31-34	Protein lin-14	Caenorhabditis elegans	14-20
9738501-8	1998	Expression of lin-14(+) in the DDs of lin-14-null mutants rescues the precocious remodelling, indicating that lin-14 can act cell-autonomously.	Fumigant 93	31-34	Protein lin-14	Caenorhabditis elegans	38-44
9738501-8	1998	Expression of lin-14(+) in the DDs of lin-14-null mutants rescues the precocious remodelling, indicating that lin-14 can act cell-autonomously.	Fumigant 93	31-34	Protein lin-14	Caenorhabditis elegans	38-44
9738501-9	1998	Consistent with this hypothesis, LIN-14 protein levels decrease in the DDs before remodelling.	Fumigant 93	71-74	Protein lin-14	Caenorhabditis elegans	33-39
9725224-6	1998	Only the mutation of the alpha2 domain glycosylation site significantly reduced the binding of Dd to Ly-49A and Ly-49C.	Fumigant 93	95-97	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	101-107
9725224-6	1998	Only the mutation of the alpha2 domain glycosylation site significantly reduced the binding of Dd to Ly-49A and Ly-49C.	Fumigant 93	95-97	killer cell lectin-like receptor, subfamily A, member 3	Mus musculus	112-118
9574541-7	1998	NZB1.1 binds isolated Ly-49A immobilized on solid phase through an interaction by cell surface Dd, since cell adhesion was blocked by Abs directed against Dd or Ly-49A.	Fumigant 93	95-97	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	22-28
9574541-7	1998	NZB1.1 binds isolated Ly-49A immobilized on solid phase through an interaction by cell surface Dd, since cell adhesion was blocked by Abs directed against Dd or Ly-49A.	Fumigant 93	95-97	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	161-167
9574541-7	1998	NZB1.1 binds isolated Ly-49A immobilized on solid phase through an interaction by cell surface Dd, since cell adhesion was blocked by Abs directed against Dd or Ly-49A.	Fumigant 93	155-157	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	22-28
9407415-11	1997	Thus, in the DD group, individuals with a high sodium excretion had a less effective response to ACEi.	Fumigant 93	13-15	angiotensin I converting enzyme	Homo sapiens	97-101
12016801-7	1999	Although the distribution of DD, ID, and II genotypes of the ACE gene did not differ among the three groups, serum ACE activity was significantly higher in Type II diabetic patients with diabetic nephropathy than in that without diabetic nephropathy(P &lt; 0.05), especially in the groups with D allele of ACE gene.	Fumigant 93	29-31	angiotensin I converting enzyme	Homo sapiens	61-64
9409318-12	1997	These results suggest that the increased ACE activity caused by DD polymorphism may play an important role in elevating the level of plasma PAI-1.	Fumigant 93	64-66	serpin family E member 1	Homo sapiens	140-145
9094266-3	1997	Here we report the effects of n-octyl sulphate (OS-) and n-dodecyl sulphate (DDS-) on RCK1 (Kv1.1), RCK4 (Kv1.4) and Shaker B potassium channels exogenously expressed in Xenopus oocytes.	Fumigant 93	77-80	potassium channel, voltage gated shaker related subfamily A, member 1 S homeolog	Xenopus laevis	92-97
9434480-0	1997	[DDS for insulin--development of non-injection dosage forms].	Fumigant 93	1-4	insulin	Homo sapiens	9-16
8723740-6	1996	Hepatic cytochrome P450 (CYP) content, ethoxyresorufin O-deethylase activities, and levels of metabolites arising from phase I metabolism were doubled after repeat oral administration of DDS, but benzphetamine N-demethylase activity was unchanged.	Fumigant 93	187-190	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	8-23
8977325-7	1996	These results suggest that the avidity of Ly-49A for Dd is relatively high and indicate that small changes in Ly-49A density near the threshold result in large changes in stable Ly-49A receptor engagement.	Fumigant 93	53-55	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	42-48
8977325-7	1996	These results suggest that the avidity of Ly-49A for Dd is relatively high and indicate that small changes in Ly-49A density near the threshold result in large changes in stable Ly-49A receptor engagement.	Fumigant 93	53-55	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	110-116
8977325-7	1996	These results suggest that the avidity of Ly-49A for Dd is relatively high and indicate that small changes in Ly-49A density near the threshold result in large changes in stable Ly-49A receptor engagement.	Fumigant 93	53-55	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	110-116
8814359-3	1996	Plasma renin was reduced by 52 +/- 15 S.E.% in DD and by 24 +/- 12% in ID hypertensives when compared to II hypertensives (P &lt; 0.05 by one-way ANOVA), but in the normotensive subjects, renin values were similar for each genotype.	Fumigant 93	47-49	renin	Homo sapiens	7-12
8723740-6	1996	Hepatic cytochrome P450 (CYP) content, ethoxyresorufin O-deethylase activities, and levels of metabolites arising from phase I metabolism were doubled after repeat oral administration of DDS, but benzphetamine N-demethylase activity was unchanged.	Fumigant 93	187-190	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	25-28
8642082-11	1996	Mast cell degranulation may lead to activation of DDs and increased factor XIIIa transglutaminase expression, via the action of tumor necrosis factor-alpha.	Fumigant 93	50-53	tumor necrosis factor	Homo sapiens	128-155
8704045-7	1996	A newly established association between DD genotype and cerebral atherosclerosis, detected even in our small group, supports the view that angiotensin-converting enzyme polymorphism might be indicative of the development of cerebral atherosclerosis.	Fumigant 93	40-42	angiotensin I converting enzyme	Homo sapiens	139-168
33798536-1	2021	HLA-B*13:01 is associated with dapsone (DDS)-induced hypersensitivity and it has been shown that CD4+ and CD8+ T cells are activated by DDS and its nitroso metabolite (DDS-NO).	Fumigant 93	40-43	major histocompatibility complex, class I, B	Homo sapiens	0-5
8315379-4	1993	We examined the expression of Ly-49, which is strongly expressed on a subpopulation of NK cells of H-2b mice, but not by NK cells of H-2a mice, probably because of a negative effect induced by the interaction of Ly-49 with Dd.	Fumigant 93	223-225	killer cell lectin-like receptor, subfamily A	Mus musculus	30-35
2026644-1	1991	Albumin and fibrinogen were competitively adsorbed onto dimethyldichlorosilane-coated glass (DDS-glass) and platelet activation was examined as a function of the surface fibrinogen concentration.	Fumigant 93	93-96	fibrinogen beta chain	Homo sapiens	12-22
7541307-3	1995	By loading the mostly empty Dd class I molecules of cell lines deficient in peptide transporter molecules with synthetic or natural Dd-bound peptides, we have demonstrated specific dose-dependent inhibition of the Ly49+ subset of activated NK cells by class I-peptide complexes.	Fumigant 93	28-30	killer cell lectin like receptor A1, pseudogene	Homo sapiens	214-218
7541307-3	1995	By loading the mostly empty Dd class I molecules of cell lines deficient in peptide transporter molecules with synthetic or natural Dd-bound peptides, we have demonstrated specific dose-dependent inhibition of the Ly49+ subset of activated NK cells by class I-peptide complexes.	Fumigant 93	132-134	killer cell lectin like receptor A1, pseudogene	Homo sapiens	214-218
8077656-7	1994	These data establish that Dd itself is sufficient for this effect and suggest that Ly-49 engages Dd-alpha 1/alpha 2 domains.	Fumigant 93	26-28	killer cell lectin-like receptor, subfamily A	Mus musculus	83-88
2393381-4	1990	DD/S had a double band of serum LAP as well as isozymes of intestinal LAP and AKP unlike those of other strains.	Fumigant 93	0-2	leucine aminopeptidase 3	Mus musculus	32-35
2393381-4	1990	DD/S had a double band of serum LAP as well as isozymes of intestinal LAP and AKP unlike those of other strains.	Fumigant 93	0-2	leucine aminopeptidase 3	Mus musculus	70-73
33798536-1	2021	HLA-B*13:01 is associated with dapsone (DDS)-induced hypersensitivity and it has been shown that CD4+ and CD8+ T cells are activated by DDS and its nitroso metabolite (DDS-NO).	Fumigant 93	40-43	CD4 molecule	Homo sapiens	97-100
33798536-1	2021	HLA-B*13:01 is associated with dapsone (DDS)-induced hypersensitivity and it has been shown that CD4+ and CD8+ T cells are activated by DDS and its nitroso metabolite (DDS-NO).	Fumigant 93	40-43	CD8a molecule	Homo sapiens	106-109
33798536-1	2021	HLA-B*13:01 is associated with dapsone (DDS)-induced hypersensitivity and it has been shown that CD4+ and CD8+ T cells are activated by DDS and its nitroso metabolite (DDS-NO).	Fumigant 93	136-139	major histocompatibility complex, class I, B	Homo sapiens	0-5
33798536-1	2021	HLA-B*13:01 is associated with dapsone (DDS)-induced hypersensitivity and it has been shown that CD4+ and CD8+ T cells are activated by DDS and its nitroso metabolite (DDS-NO).	Fumigant 93	136-139	CD4 molecule	Homo sapiens	97-100
33798536-1	2021	HLA-B*13:01 is associated with dapsone (DDS)-induced hypersensitivity and it has been shown that CD4+ and CD8+ T cells are activated by DDS and its nitroso metabolite (DDS-NO).	Fumigant 93	136-139	CD8a molecule	Homo sapiens	106-109
33798536-4	2021	CD8+ TCC were stimulated to proliferate and secrete effector molecules when exposed to DDS and/or DDS-NO.	Fumigant 93	87-90	CD8a molecule	Homo sapiens	0-3
33798536-5	2021	DDS-responsive and several DDS-NO-responsive TCC expressing a variety of TCR sequences displayed HLA class-I-restriction, with the drug(metabolite) interacting with multiple HLA-B alleles.	Fumigant 93	0-3	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	73-76
33798536-9	2021	To conclude, DDS and DDS-NO interact with a number of HLA molecules to activate CD8+ TCC, with HLA class-II-restricted CD8+ TCC that display hybrid CD4/CD8 features also contributing to the promiscuous immune response that develops in patients.	Fumigant 93	13-16	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	54-57
33798536-9	2021	To conclude, DDS and DDS-NO interact with a number of HLA molecules to activate CD8+ TCC, with HLA class-II-restricted CD8+ TCC that display hybrid CD4/CD8 features also contributing to the promiscuous immune response that develops in patients.	Fumigant 93	13-16	CD8a molecule	Homo sapiens	80-83