PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33655698-8	2021	Histone-lysine N-methyltransferase 2 (KMT2) family members (KMT2A, KMT2C, and KMT2D) were frequently mutated in NSCLC tumors, and these mutations were associated with higher TMB and PD-L1 expression, as well as higher PD-L1+/TMB-H proportions.	tyrosyl-lysine	8-14	lysine methyltransferase 2A	Homo sapiens	60-65
303241-5	1977	Its amino acid composition and apparent molecular weight estimated by Sephadex G-25 chromatography, indicate that FTS is a nonapeptide of composition lysine, aspartic acid (or asparagine), serine 2, glutamic acid (or glutamine) 2, glycine 2, and alanine.	tyrosyl-lysine	150-156	AKT interacting protein	Homo sapiens	114-117
303770-0	1977	Specific lysine labeling by 18OH- during alkaline cleavage of the alpha-1-antitrypsin-trypsin complex.	tyrosyl-lysine	9-15	serpin family A member 1	Homo sapiens	66-85
303770-5	1977	In order to determine whether the alpha-1-antitrypsin is bound to trypsin through the new carboxy-terminal lysine, as would be expected if the above hypothesis is correct, we split the complex in the presence of 18OH-.	tyrosyl-lysine	107-113	serpin family A member 1	Homo sapiens	34-53
303770-6	1977	When the new carboxy-terminal lysine was cleaved with carboxypeptidase B, singly labeled, doubly labeled, and unlabeled lysine were recovered.	tyrosyl-lysine	30-36	carboxypeptidase B1	Homo sapiens	54-72
33655698-8	2021	Histone-lysine N-methyltransferase 2 (KMT2) family members (KMT2A, KMT2C, and KMT2D) were frequently mutated in NSCLC tumors, and these mutations were associated with higher TMB and PD-L1 expression, as well as higher PD-L1+/TMB-H proportions.	tyrosyl-lysine	8-14	lysine methyltransferase 2C	Homo sapiens	67-72
33655698-8	2021	Histone-lysine N-methyltransferase 2 (KMT2) family members (KMT2A, KMT2C, and KMT2D) were frequently mutated in NSCLC tumors, and these mutations were associated with higher TMB and PD-L1 expression, as well as higher PD-L1+/TMB-H proportions.	tyrosyl-lysine	8-14	lysine methyltransferase 2D	Homo sapiens	78-83
33655698-8	2021	Histone-lysine N-methyltransferase 2 (KMT2) family members (KMT2A, KMT2C, and KMT2D) were frequently mutated in NSCLC tumors, and these mutations were associated with higher TMB and PD-L1 expression, as well as higher PD-L1+/TMB-H proportions.	tyrosyl-lysine	8-14	CD274 molecule	Homo sapiens	182-187
33655698-8	2021	Histone-lysine N-methyltransferase 2 (KMT2) family members (KMT2A, KMT2C, and KMT2D) were frequently mutated in NSCLC tumors, and these mutations were associated with higher TMB and PD-L1 expression, as well as higher PD-L1+/TMB-H proportions.	tyrosyl-lysine	8-14	CD274 molecule	Homo sapiens	218-223
32045348-2	2020	EZH2 catalyzes the methylation of lysine 27 of histone H3, a modification associated with gene silencing.	tyrosyl-lysine	34-40	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
31902296-2	2021	Suppressor of variegation 4-20 homolog 1 (SUV420H1), a member of class Histone Lysine Methyltransferase and a key enzyme in the epigenetic regulation of the pathways controlling metabolism and tumorigenesis, is crucial to maintain cell homeostasis.	tyrosyl-lysine	79-85	lysine methyltransferase 5B	Homo sapiens	0-40
31902296-2	2021	Suppressor of variegation 4-20 homolog 1 (SUV420H1), a member of class Histone Lysine Methyltransferase and a key enzyme in the epigenetic regulation of the pathways controlling metabolism and tumorigenesis, is crucial to maintain cell homeostasis.	tyrosyl-lysine	79-85	lysine methyltransferase 5B	Homo sapiens	42-50
32001024-3	2020	Novel factors have been identified that ensure DSB-induced silencing via two distinct pathways: direct inhibition of RNA Polymerase II (Pol II) mediated by negative elongation factor (NELF), and histone code editing by CDYL1 and histone deacetylases (HDACs) that catalyze H3K27me3 and erase lysine crotonylation, respectively.	tyrosyl-lysine	291-297	NMDA receptor synaptonuclear signaling and neuronal migration factor	Homo sapiens	156-182
32001024-3	2020	Novel factors have been identified that ensure DSB-induced silencing via two distinct pathways: direct inhibition of RNA Polymerase II (Pol II) mediated by negative elongation factor (NELF), and histone code editing by CDYL1 and histone deacetylases (HDACs) that catalyze H3K27me3 and erase lysine crotonylation, respectively.	tyrosyl-lysine	291-297	NMDA receptor synaptonuclear signaling and neuronal migration factor	Homo sapiens	184-188
32001024-3	2020	Novel factors have been identified that ensure DSB-induced silencing via two distinct pathways: direct inhibition of RNA Polymerase II (Pol II) mediated by negative elongation factor (NELF), and histone code editing by CDYL1 and histone deacetylases (HDACs) that catalyze H3K27me3 and erase lysine crotonylation, respectively.	tyrosyl-lysine	291-297	chromodomain Y like	Homo sapiens	219-224
32052226-5	2020	Here, we have shown that bicuculline induced GluA2 ubiquitination on the same lysine residues (Lys-870 and Lys-882) in the C-terminal as those elicited by the AMPA treatment.	tyrosyl-lysine	78-84	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	45-50
32068261-2	2020	This study was conducted to elucidate the effects lncRNA lymphoid enhancer-binding Factor 1 antisense RNA (LEF1-AS1) on the pathological development of HCC, along with the crosstalk involving microRNA-136-5p (miR-136-5p) and with-no-K (lysine) kinase 1 (WNK1).	tyrosyl-lysine	236-242	LEF1 antisense RNA 1	Homo sapiens	107-115
31722069-1	2020	SUGCT (C7orf10) is a mitochondrial enzyme that synthesizes glutaryl-CoA from glutarate in tryptophan and lysine catabolism, but it has not been studied in vivo.	tyrosyl-lysine	105-111	succinyl-CoA glutarate-CoA transferase	Mus musculus	0-5
31878840-3	2020	Here, we demonstrate that the histone acetyltransferase KAT2A/GCN5 (lysine acetyltransferase 2) binds directly to the autophagosome protein MAP1LC3/LC3 (microtubule associated protein 1 light chain 3) via a conserved LC3-interacting region (LIR) domain.	tyrosyl-lysine	68-74	lysine acetyltransferase 2A	Homo sapiens	56-61
31878840-3	2020	Here, we demonstrate that the histone acetyltransferase KAT2A/GCN5 (lysine acetyltransferase 2) binds directly to the autophagosome protein MAP1LC3/LC3 (microtubule associated protein 1 light chain 3) via a conserved LC3-interacting region (LIR) domain.	tyrosyl-lysine	68-74	lysine acetyltransferase 2A	Homo sapiens	62-66
31878840-3	2020	Here, we demonstrate that the histone acetyltransferase KAT2A/GCN5 (lysine acetyltransferase 2) binds directly to the autophagosome protein MAP1LC3/LC3 (microtubule associated protein 1 light chain 3) via a conserved LC3-interacting region (LIR) domain.	tyrosyl-lysine	68-74	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	144-147
31878840-3	2020	Here, we demonstrate that the histone acetyltransferase KAT2A/GCN5 (lysine acetyltransferase 2) binds directly to the autophagosome protein MAP1LC3/LC3 (microtubule associated protein 1 light chain 3) via a conserved LC3-interacting region (LIR) domain.	tyrosyl-lysine	68-74	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	148-151
31990985-2	2020	In the current study, we present novel evidence that the histone-lysine methyltransferase G9a is upregulated in human CCA and that G9a enhances CCA cell growth and invasiveness through regulation of the Hippo pathway kinase LATS2 and YAP signaling pathway.	tyrosyl-lysine	65-71	large tumor suppressor kinase 2	Homo sapiens	224-229
31990985-2	2020	In the current study, we present novel evidence that the histone-lysine methyltransferase G9a is upregulated in human CCA and that G9a enhances CCA cell growth and invasiveness through regulation of the Hippo pathway kinase LATS2 and YAP signaling pathway.	tyrosyl-lysine	65-71	Yes1 associated transcriptional regulator	Homo sapiens	234-237
32061735-1	2020	The transglutaminase (TGase) family consists of eight isozymes that catalyze the Ca2+-dependent crosslink formation between the glutamine and lysine residues of proteins.	tyrosyl-lysine	142-148	transglutaminase 1	Homo sapiens	4-20
32061735-1	2020	The transglutaminase (TGase) family consists of eight isozymes that catalyze the Ca2+-dependent crosslink formation between the glutamine and lysine residues of proteins.	tyrosyl-lysine	142-148	transglutaminase 1	Homo sapiens	22-27
32006024-2	2020	We have found that a part of mouse mIgG1 is ubiquitinated through the two responsible lysine residues (K378 and K386) in its cytoplasmic tail and this ubiquitination is augmented upon antigen stimulation.	tyrosyl-lysine	86-92	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	35-40
31638140-4	2020	Our previous work identified the histone lysine methyltransferase Nuclear Receptor Binding SET Domain protein 3 (NSD3) as a MYC modulator.	tyrosyl-lysine	41-47	nuclear receptor binding SET domain protein 3	Homo sapiens	113-117
31638140-4	2020	Our previous work identified the histone lysine methyltransferase Nuclear Receptor Binding SET Domain protein 3 (NSD3) as a MYC modulator.	tyrosyl-lysine	41-47	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	124-127
31863092-4	2020	Here, we show that kinetochore PLK1 kinase activity is modulated by SET7/9 via lysine methylation during early mitosis.	tyrosyl-lysine	79-85	polo like kinase 1	Homo sapiens	31-35
31863092-4	2020	Here, we show that kinetochore PLK1 kinase activity is modulated by SET7/9 via lysine methylation during early mitosis.	tyrosyl-lysine	79-85	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	68-74
32060676-1	2020	In this work, we analyze the structure-activity relationships (SAR) of epigenetic inhibitors (lysine mimetics) against lysine methyltransferase (G9a or EHMT2) using a combined activity landscape, molecular docking and molecular dynamics approach.	tyrosyl-lysine	94-100	euchromatic histone lysine methyltransferase 2	Homo sapiens	152-157
31951058-3	2020	MYB30 can be SUMOylated by SIZ1 in response to salt stress and the Lysine (K)283 of MYB30 is essential for its SUMOylation.	tyrosyl-lysine	67-73	myb domain protein 30	Arabidopsis thaliana	0-5
31951058-3	2020	MYB30 can be SUMOylated by SIZ1 in response to salt stress and the Lysine (K)283 of MYB30 is essential for its SUMOylation.	tyrosyl-lysine	67-73	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	27-31
31951058-3	2020	MYB30 can be SUMOylated by SIZ1 in response to salt stress and the Lysine (K)283 of MYB30 is essential for its SUMOylation.	tyrosyl-lysine	67-73	myb domain protein 30	Arabidopsis thaliana	84-89
31907393-9	2020	The lysine residues (K51 and K68) are essential for ubiquitination and proteasomal degradation of ERRalpha by CA.	tyrosyl-lysine	4-10	estrogen related receptor alpha	Homo sapiens	98-106
31755110-1	2020	Lysine-specific demethylase 1 (LSD1), a histone lysine demethylase with main specificity for H3K4me2, has been shown to be overexpressed in rhabdomyosarcoma (RMS) tumor samples.	tyrosyl-lysine	48-54	lysine demethylase 1A	Homo sapiens	0-29
31755110-1	2020	Lysine-specific demethylase 1 (LSD1), a histone lysine demethylase with main specificity for H3K4me2, has been shown to be overexpressed in rhabdomyosarcoma (RMS) tumor samples.	tyrosyl-lysine	48-54	lysine demethylase 1A	Homo sapiens	31-35
32044379-10	2020	We further determined that loss of prdm3 and prdm16 reduces methylation of histone 3 lysine 9 (repression) and histone 3 lysine 4 (activation) in zebrafish.	tyrosyl-lysine	85-91	MDS1 and EVI1 complex locus	Danio rerio	35-40
32044379-10	2020	We further determined that loss of prdm3 and prdm16 reduces methylation of histone 3 lysine 9 (repression) and histone 3 lysine 4 (activation) in zebrafish.	tyrosyl-lysine	85-91	PR domain containing 16	Danio rerio	45-51
32044379-10	2020	We further determined that loss of prdm3 and prdm16 reduces methylation of histone 3 lysine 9 (repression) and histone 3 lysine 4 (activation) in zebrafish.	tyrosyl-lysine	121-127	MDS1 and EVI1 complex locus	Danio rerio	35-40
32044379-10	2020	We further determined that loss of prdm3 and prdm16 reduces methylation of histone 3 lysine 9 (repression) and histone 3 lysine 4 (activation) in zebrafish.	tyrosyl-lysine	121-127	PR domain containing 16	Danio rerio	45-51
32044379-11	2020	In mice, loss of Prdm16 significantly decreased histone 3 lysine 9 methylation in the palatal shelves but surprisingly did not change histone 3 lysine 4 methylation.	tyrosyl-lysine	58-64	PR domain containing 16	Mus musculus	17-23
31916512-4	2020	In this study, we confirmed that Zfp521 can be modified by SUMO1 and lysine 1146 was the primary SUMOylation site.	tyrosyl-lysine	69-75	zinc finger protein 521	Mus musculus	33-39
31907922-3	2020	A critical histone mark is trimethylation of histone H3 at lysine residue 27 (H3K27me3), which is mediated by Ezh2, the catalytic subunit of the polycomb group complex PRC2 to repress transcription.	tyrosyl-lysine	59-65	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	110-114
31544250-3	2020	In this study, we found that the WD repeat domain 5 protein (WDR5)-a core subunit of histone H3 lysine 4 methyltransferase complexes, which catalyze the generation of histone H3 lysine 4 trimethylation (H3K4me3) modification-is highly expressed in HBV-related HCC and promotes HCC development.	tyrosyl-lysine	96-102	WD repeat domain 5	Homo sapiens	33-51
31544250-3	2020	In this study, we found that the WD repeat domain 5 protein (WDR5)-a core subunit of histone H3 lysine 4 methyltransferase complexes, which catalyze the generation of histone H3 lysine 4 trimethylation (H3K4me3) modification-is highly expressed in HBV-related HCC and promotes HCC development.	tyrosyl-lysine	96-102	WD repeat domain 5	Homo sapiens	61-65
31544250-3	2020	In this study, we found that the WD repeat domain 5 protein (WDR5)-a core subunit of histone H3 lysine 4 methyltransferase complexes, which catalyze the generation of histone H3 lysine 4 trimethylation (H3K4me3) modification-is highly expressed in HBV-related HCC and promotes HCC development.	tyrosyl-lysine	178-184	WD repeat domain 5	Homo sapiens	33-51
31544250-3	2020	In this study, we found that the WD repeat domain 5 protein (WDR5)-a core subunit of histone H3 lysine 4 methyltransferase complexes, which catalyze the generation of histone H3 lysine 4 trimethylation (H3K4me3) modification-is highly expressed in HBV-related HCC and promotes HCC development.	tyrosyl-lysine	178-184	WD repeat domain 5	Homo sapiens	61-65
31834666-3	2020	The oxidative deamination of peptidyl lysine to peptidyl allysine in elastin"s precursor tropoelastin is a crucial posttranslational step in their formation.	tyrosyl-lysine	38-44	elastin	Homo sapiens	69-76
31834666-3	2020	The oxidative deamination of peptidyl lysine to peptidyl allysine in elastin"s precursor tropoelastin is a crucial posttranslational step in their formation.	tyrosyl-lysine	38-44	elastin	Homo sapiens	89-101
31652343-1	2020	Certain loss-of-function mutations in the gene encoding the lysine catabolic enzyme aldehyde dehydrogenase 7A1 (ALDH7A1) cause pyridoxine-dependent epilepsy (PDE).	tyrosyl-lysine	60-66	aldehyde dehydrogenase 7 family member A1	Homo sapiens	84-110
31652343-1	2020	Certain loss-of-function mutations in the gene encoding the lysine catabolic enzyme aldehyde dehydrogenase 7A1 (ALDH7A1) cause pyridoxine-dependent epilepsy (PDE).	tyrosyl-lysine	60-66	aldehyde dehydrogenase 7 family member A1	Homo sapiens	112-119
31692222-1	2020	We have discovered the sirtuin rearranging ligands (SirReals) as highly potent and selective inhibitors of the NAD+-dependent lysine deacetylase Sirt2.	tyrosyl-lysine	126-132	sirtuin 2	Homo sapiens	145-150
31960028-0	2020	A crucial RNA-binding lysine residue in the Nab3 RRM domain undergoes SET1 and SET3-responsive methylation.	tyrosyl-lysine	22-28	Nab3p	Saccharomyces cerevisiae S288C	44-48
31960028-0	2020	A crucial RNA-binding lysine residue in the Nab3 RRM domain undergoes SET1 and SET3-responsive methylation.	tyrosyl-lysine	22-28	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	70-74
31960028-0	2020	A crucial RNA-binding lysine residue in the Nab3 RRM domain undergoes SET1 and SET3-responsive methylation.	tyrosyl-lysine	22-28	histone-binding protein SET3	Saccharomyces cerevisiae S288C	79-83
31960028-4	2020	In this study, we identify nine lysine residues distributed amongst Nrd1, Nab3 and Sen1 that are methylated, suggesting novel molecular inputs for NNS regulation.	tyrosyl-lysine	32-38	Nrd1 complex RNA-binding subunit	Saccharomyces cerevisiae S288C	68-72
31960028-4	2020	In this study, we identify nine lysine residues distributed amongst Nrd1, Nab3 and Sen1 that are methylated, suggesting novel molecular inputs for NNS regulation.	tyrosyl-lysine	32-38	Nab3p	Saccharomyces cerevisiae S288C	74-78
31960028-4	2020	In this study, we identify nine lysine residues distributed amongst Nrd1, Nab3 and Sen1 that are methylated, suggesting novel molecular inputs for NNS regulation.	tyrosyl-lysine	32-38	putative DNA/RNA helicase SEN1	Saccharomyces cerevisiae S288C	83-87
31970415-5	2020	Once at the damage sites, CHD4 displaces heterochromatin protein 1 (HP1) from histone H3 lysine 9 trimethylation (H3K9me3).	tyrosyl-lysine	89-95	chromodomain helicase DNA binding protein 4	Homo sapiens	26-30
31970415-5	2020	Once at the damage sites, CHD4 displaces heterochromatin protein 1 (HP1) from histone H3 lysine 9 trimethylation (H3K9me3).	tyrosyl-lysine	89-95	chromobox 5	Homo sapiens	41-66
31970415-5	2020	Once at the damage sites, CHD4 displaces heterochromatin protein 1 (HP1) from histone H3 lysine 9 trimethylation (H3K9me3).	tyrosyl-lysine	89-95	chromobox 5	Homo sapiens	68-71
31609499-1	2020	"Myxoid glioneuronal tumor, PDGFRA p.K385-mutant" is a recently described tumor entity of the central nervous system with a predilection for origin in the septum pellucidum and a defining dinucleotide mutation at codon 385 of the PDGFRA oncogene replacing lysine with either leucine or isoleucine (p.K385L/I).	tyrosyl-lysine	256-262	platelet derived growth factor receptor alpha	Homo sapiens	28-34
31609499-1	2020	"Myxoid glioneuronal tumor, PDGFRA p.K385-mutant" is a recently described tumor entity of the central nervous system with a predilection for origin in the septum pellucidum and a defining dinucleotide mutation at codon 385 of the PDGFRA oncogene replacing lysine with either leucine or isoleucine (p.K385L/I).	tyrosyl-lysine	256-262	platelet derived growth factor receptor alpha	Homo sapiens	230-236
31713291-6	2020	We also identified multiple lysine residues on Chk1 that are poly-ubiquitinated by HUWE1 in vitro, many of which are within the kinase domain.	tyrosyl-lysine	28-34	checkpoint kinase 1	Homo sapiens	47-51
31713291-6	2020	We also identified multiple lysine residues on Chk1 that are poly-ubiquitinated by HUWE1 in vitro, many of which are within the kinase domain.	tyrosyl-lysine	28-34	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Homo sapiens	83-88
31677131-1	2020	BACKGROUND: Jumonji domain-containing protein 2A (JMJD2A) of the JMJD2 family of histone lysine demethylases has been implicated in tumorigenesis.	tyrosyl-lysine	89-95	lysine demethylase 4A	Homo sapiens	12-48
31677131-1	2020	BACKGROUND: Jumonji domain-containing protein 2A (JMJD2A) of the JMJD2 family of histone lysine demethylases has been implicated in tumorigenesis.	tyrosyl-lysine	89-95	lysine demethylase 4A	Homo sapiens	50-56
31677131-1	2020	BACKGROUND: Jumonji domain-containing protein 2A (JMJD2A) of the JMJD2 family of histone lysine demethylases has been implicated in tumorigenesis.	tyrosyl-lysine	89-95	lysine demethylase 4A	Homo sapiens	50-55
32003940-1	2020	To design highly effective covalent inhibitors of LSD1, a lysine demethylase highly involved in initiation and development of cancer, a strategy is to fill its large catalytic cleft by designing tranylcypromine (TCP) analogs decorated with long, hindered substituents.	tyrosyl-lysine	58-64	lysine demethylase 1A	Homo sapiens	50-54
31903696-10	2020	Mechanistically, we found that UNC5B-AS1 interacted with zeste 2 polycomb repressive complex 2 subunit (EZH2) to trigger trimethylation of histone H3 at lysine 27 (H3K27me3) on N-myc downstream regulated gene-2 (NDRG2) promoter and epigenetically repress NDRG2.	tyrosyl-lysine	153-159	UNC5B antisense RNA 1	Homo sapiens	31-40
31903696-10	2020	Mechanistically, we found that UNC5B-AS1 interacted with zeste 2 polycomb repressive complex 2 subunit (EZH2) to trigger trimethylation of histone H3 at lysine 27 (H3K27me3) on N-myc downstream regulated gene-2 (NDRG2) promoter and epigenetically repress NDRG2.	tyrosyl-lysine	153-159	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	104-108
31753928-8	2020	An administration of a lysine-rich histone results in more severe and persistent thrombocytopenia and a significantly increased mortality rate in a13-/- than in wild type (wt) zebrafish.	tyrosyl-lysine	23-29	ADAM metallopeptidase with thrombospondin type 1 motif, 13	Danio rerio	146-149
32057430-5	2020	When alpha-lactose was also present, 7 lysine side-chains in beta-LG were modified by glycation and the IgG/IgE binding capacity was further decreased.	tyrosyl-lysine	39-45	beta-lactoglobulin	Bos taurus	61-68
32062438-17	2020	Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis.	tyrosyl-lysine	243-249	aryl-hydrocarbon receptor	Mus musculus	165-190
32062438-17	2020	Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis.	tyrosyl-lysine	243-249	aryl-hydrocarbon receptor	Mus musculus	192-195
32062438-17	2020	Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis.	tyrosyl-lysine	319-325	aryl-hydrocarbon receptor	Mus musculus	165-190
32062438-17	2020	Mechanistic studies revealed that arsenic and BaP co-exposure does not produce more BPDE-DNA adducts than BaP exposure alone; but acts synergistically in activating aryl hydrocarbon receptor (AhR) to up-regulate the expression of a histone H3 lysine 9 methyltransferase SUV39H1 and increase the level of suppressive H3 lysine 9 dimethylation (H3K9me2), which down-regulates the expression of tumor suppressive SOCS3 leading to enhanced activation of Akt and Erk1/2 to promote cell transformation, CSC-like property and tumorigenesis.	tyrosyl-lysine	319-325	aryl-hydrocarbon receptor	Mus musculus	192-195
31692055-3	2020	In this study, we identified two lysine sites, K21 and K123, that were critical ubiquitin-binding sites in BAX.	tyrosyl-lysine	33-39	BCL2 associated X, apoptosis regulator	Homo sapiens	107-110
32059997-1	2020	The inappropriate over-activation of the with-no-lysine kinase (WNK)-STE20/SPS1-related proline/alanine-rich kinase (SPAK)-sodium chloride cotransporter (NCC) phosphorylation cascade increases sodium reabsorption in distal kidney nephrons, resulting in salt-sensitive hypertension.	tyrosyl-lysine	49-55	serine/threonine kinase 24	Mus musculus	69-74
32059997-1	2020	The inappropriate over-activation of the with-no-lysine kinase (WNK)-STE20/SPS1-related proline/alanine-rich kinase (SPAK)-sodium chloride cotransporter (NCC) phosphorylation cascade increases sodium reabsorption in distal kidney nephrons, resulting in salt-sensitive hypertension.	tyrosyl-lysine	49-55	serine/threonine kinase 39	Mus musculus	117-121
31971317-8	2020	Overall, our study reveals that Jmjd3 is a potential epigenetic regulator for the treatment of inflammatory bowel disease (IBD), suggesting that Nrf2 is a potential target gene of Jmjd3 by mediating methylation status of trimethylated H3 lysine 27 (H3K27me3) in the promotor and is required for NLRP3 inflammasome activation, thereby providing the platform for potential future therapeutic interventions in IBD.	tyrosyl-lysine	238-244	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	32-37
31981860-8	2020	Elevated GATA6-AS1 reduced FZD4 expression by recruiting enhancer of zeste homolog 2 (EZH2) and trimethylation at lysine 27 of histone H3 (H3K27me3) to the FZD4 promoter region via the inactivated Wnt/beta-catenin signaling pathway, whereby cell invasion, migration, and proliferation, tumor growth, and LNM in nude mice were reduced.	tyrosyl-lysine	114-120	GATA binding protein 6	Mus musculus	9-18
31981860-8	2020	Elevated GATA6-AS1 reduced FZD4 expression by recruiting enhancer of zeste homolog 2 (EZH2) and trimethylation at lysine 27 of histone H3 (H3K27me3) to the FZD4 promoter region via the inactivated Wnt/beta-catenin signaling pathway, whereby cell invasion, migration, and proliferation, tumor growth, and LNM in nude mice were reduced.	tyrosyl-lysine	114-120	frizzled class receptor 4	Mus musculus	27-31
31981860-8	2020	Elevated GATA6-AS1 reduced FZD4 expression by recruiting enhancer of zeste homolog 2 (EZH2) and trimethylation at lysine 27 of histone H3 (H3K27me3) to the FZD4 promoter region via the inactivated Wnt/beta-catenin signaling pathway, whereby cell invasion, migration, and proliferation, tumor growth, and LNM in nude mice were reduced.	tyrosyl-lysine	114-120	frizzled class receptor 4	Mus musculus	156-160
31863900-0	2020	Long non-coding RNA DANCR promotes colorectal tumor growth by binding to lysine acetyltransferase 6A.	tyrosyl-lysine	73-79	differentiation antagonizing non-protein coding RNA	Homo sapiens	20-25
31863900-6	2020	We further demonstrated that DANCR bound with lysine acetyltransferase 6A.	tyrosyl-lysine	46-52	differentiation antagonizing non-protein coding RNA	Homo sapiens	29-34
31729169-4	2020	We studied a chemical inhibitor of LSD1 (ORY-1001), a lysine-specific histone demethylase enzyme with epigenetic function, and drug-induced regulation of target engagement, biomarker levels, and tumor cell growth across multiple doses administered in a pulsed and continuous fashion.	tyrosyl-lysine	54-60	lysine demethylase 1A	Homo sapiens	35-39
31981592-1	2020	SET domain-containing 5 (SETD5) is an uncharacterized member of the protein lysine methyltransferase family.	tyrosyl-lysine	76-82	SET domain containing 5	Homo sapiens	0-23
31981592-1	2020	SET domain-containing 5 (SETD5) is an uncharacterized member of the protein lysine methyltransferase family.	tyrosyl-lysine	76-82	SET domain containing 5	Homo sapiens	25-30
31628953-4	2020	Here we review how protein lysine acetylation contributes to the regulation of mitochondrial metabolism in insulin target tissues and the insulin secreting pancreatic beta-cell.	tyrosyl-lysine	27-33	insulin	Homo sapiens	107-114
31628953-8	2020	In contrast, nutrient oversupply, oxidative stress or inhibition of the mitochondrial deacetylase SIRT3 leads to protein lysine hyperacetylation, which impairs mitochondrial function.	tyrosyl-lysine	121-127	sirtuin 3	Homo sapiens	98-103
31830648-8	2020	EZH2 promoted triple methylation of lysine 27 (H3K27) in the ABCA1 promoter region.	tyrosyl-lysine	36-42	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
31830648-8	2020	EZH2 promoted triple methylation of lysine 27 (H3K27) in the ABCA1 promoter region.	tyrosyl-lysine	36-42	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	61-66
32059342-10	2020	What"s more, the biological function of LINC00460 was mediated, to certain extent, by the direct interaction with enhancer of zeste homolog 2 (EZH2) and lysine (K)-specific demethylase 1A (LSD1) proteins.	tyrosyl-lysine	153-159	long intergenic non-protein coding RNA 460	Homo sapiens	40-49
31967804-6	2020	This study reveals that lysine is a possible binding location for Os1-Cl, apart from the expected binding sites at methionine, histidine, and cysteine.	tyrosyl-lysine	24-30	frizzled related protein	Homo sapiens	66-69
31846841-1	2020	OBJECTIVES: Modification of lysine 4 on histone H3 methylation by SET1 and MLL family methyltransferase complexes is tightly linked to cancer progression.	tyrosyl-lysine	28-34	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	66-70
31846841-1	2020	OBJECTIVES: Modification of lysine 4 on histone H3 methylation by SET1 and MLL family methyltransferase complexes is tightly linked to cancer progression.	tyrosyl-lysine	28-34	lysine methyltransferase 2A	Homo sapiens	75-78
31709711-9	2020	ATF3 represses the association of the activating mark, acetyl histone H4 lysine 8 (H4AcK8) at the promoter of Ch25h.	tyrosyl-lysine	73-79	activating transcription factor 3	Mus musculus	0-4
31971317-8	2020	Overall, our study reveals that Jmjd3 is a potential epigenetic regulator for the treatment of inflammatory bowel disease (IBD), suggesting that Nrf2 is a potential target gene of Jmjd3 by mediating methylation status of trimethylated H3 lysine 27 (H3K27me3) in the promotor and is required for NLRP3 inflammasome activation, thereby providing the platform for potential future therapeutic interventions in IBD.	tyrosyl-lysine	238-244	nuclear factor, erythroid derived 2, like 2	Mus musculus	145-149
31971317-8	2020	Overall, our study reveals that Jmjd3 is a potential epigenetic regulator for the treatment of inflammatory bowel disease (IBD), suggesting that Nrf2 is a potential target gene of Jmjd3 by mediating methylation status of trimethylated H3 lysine 27 (H3K27me3) in the promotor and is required for NLRP3 inflammasome activation, thereby providing the platform for potential future therapeutic interventions in IBD.	tyrosyl-lysine	238-244	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	180-185
31971317-8	2020	Overall, our study reveals that Jmjd3 is a potential epigenetic regulator for the treatment of inflammatory bowel disease (IBD), suggesting that Nrf2 is a potential target gene of Jmjd3 by mediating methylation status of trimethylated H3 lysine 27 (H3K27me3) in the promotor and is required for NLRP3 inflammasome activation, thereby providing the platform for potential future therapeutic interventions in IBD.	tyrosyl-lysine	238-244	NLR family, pyrin domain containing 3	Mus musculus	295-300
32024448-8	2020	Seven patients also had somatic mutations in APC, and seven patients harbored somatic mutations in KMT2D, which encodes a lysine methyl transferase.	tyrosyl-lysine	122-135	lysine methyltransferase 2D	Homo sapiens	99-104
31978781-1	2020	Disruptor of Telomeric Silencing 1-Like (DOT1L), the sole histone H3 lysine 79 (H3K79) methyltransferase, is required for leukemogenic transformation in a subset of leukemias bearing chromosomal translocations of the Mixed Lineage Leukemia (MLL) gene, as well as other cancers.	tyrosyl-lysine	69-75	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	0-39
31978781-1	2020	Disruptor of Telomeric Silencing 1-Like (DOT1L), the sole histone H3 lysine 79 (H3K79) methyltransferase, is required for leukemogenic transformation in a subset of leukemias bearing chromosomal translocations of the Mixed Lineage Leukemia (MLL) gene, as well as other cancers.	tyrosyl-lysine	69-75	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	41-46
31978781-1	2020	Disruptor of Telomeric Silencing 1-Like (DOT1L), the sole histone H3 lysine 79 (H3K79) methyltransferase, is required for leukemogenic transformation in a subset of leukemias bearing chromosomal translocations of the Mixed Lineage Leukemia (MLL) gene, as well as other cancers.	tyrosyl-lysine	69-75	lysine (K)-specific methyltransferase 2A	Mus musculus	217-239
31978781-1	2020	Disruptor of Telomeric Silencing 1-Like (DOT1L), the sole histone H3 lysine 79 (H3K79) methyltransferase, is required for leukemogenic transformation in a subset of leukemias bearing chromosomal translocations of the Mixed Lineage Leukemia (MLL) gene, as well as other cancers.	tyrosyl-lysine	69-75	lysine (K)-specific methyltransferase 2A	Mus musculus	241-244
32030886-0	2020	miR24-2 accelerates progression of liver cancer cells by activating Pim1 through tri-methylation of Histone H3 on the ninth lysine.	tyrosyl-lysine	124-130	microRNA 24-2	Homo sapiens	0-7
32030886-0	2020	miR24-2 accelerates progression of liver cancer cells by activating Pim1 through tri-methylation of Histone H3 on the ninth lysine.	tyrosyl-lysine	124-130	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	68-72
32030886-4	2020	Furthermore, miR6079 targets JMJD2A and then increased the tri-methylation of histone H3 on the ninth lysine (H3K9me3).	tyrosyl-lysine	102-108	microRNA 6079	Homo sapiens	13-20
32030886-4	2020	Furthermore, miR6079 targets JMJD2A and then increased the tri-methylation of histone H3 on the ninth lysine (H3K9me3).	tyrosyl-lysine	102-108	lysine demethylase 4A	Homo sapiens	29-35
31667916-9	2020	ELS increased histone 3 lysine 9 (H3K9) acetylation in the CeA and H3K9 acetylation levels at the GR promoter in the CeA of adult female rats.	tyrosyl-lysine	24-30	carcinoembryonic antigen gene family 4	Rattus norvegicus	59-62
32031206-0	2020	The Eaf3 chromodomain acts as a pH sensor for gene expression by altering its binding affinity for histone methylated-lysine residues.	tyrosyl-lysine	118-124	Eaf3p	Saccharomyces cerevisiae S288C	4-8
32031206-4	2020	Here we have explored the role of the chromodomain (CD) of budding yeast Eaf3, a common subunit of both HAT and HDAC that is thought to recognize methylated lysine residues on histone H3.	tyrosyl-lysine	157-163	Eaf3p	Saccharomyces cerevisiae S288C	73-77
32031206-5	2020	We found that Eaf3 CD interacts with histone H3 peptides methylated at Lys4 (H3K4me, a promoter epigenetic marker) and Lys36 (H3K36me, a coding region epigenetic marker), as well as with many dimethyl-lysine peptides and even arginine-asymmetrically dimethylated peptides, but not with unmethylated, phosphorylated, or acetylated peptides.	tyrosyl-lysine	192-207	Eaf3p	Saccharomyces cerevisiae S288C	14-18
32031206-5	2020	We found that Eaf3 CD interacts with histone H3 peptides methylated at Lys4 (H3K4me, a promoter epigenetic marker) and Lys36 (H3K36me, a coding region epigenetic marker), as well as with many dimethyl-lysine peptides and even arginine-asymmetrically dimethylated peptides, but not with unmethylated, phosphorylated, or acetylated peptides.	tyrosyl-lysine	192-207	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	71-75
31658420-3	2020	Crystal structures of the main antifibrinolytic targets, the lysine binding sites on plasminogen"s kringle domains and plasmin"s serine protease domain greatly contributed to structure-based drug design of novel inhibitor classes.	tyrosyl-lysine	61-67	plasminogen	Homo sapiens	85-92
31952907-1	2020	The chromatin modifier enhancer of zeste homolog 2 (EZH2) methylates lysine 27 of histone H3 (H3K27) and regulates T cell differentiation.	tyrosyl-lysine	69-75	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	23-50
31952907-1	2020	The chromatin modifier enhancer of zeste homolog 2 (EZH2) methylates lysine 27 of histone H3 (H3K27) and regulates T cell differentiation.	tyrosyl-lysine	69-75	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	52-56
31806371-1	2020	Lysine-specific demethylase 1 (LSD1) is a well characterized transcriptional regulator functioning on the chromatin to remove mono- and di-methyl groups from lysine 4 or lysine 9 of histone 3 (H3K4 or H3K9).	tyrosyl-lysine	158-164	lysine (K)-specific demethylase 1A	Mus musculus	0-29
31846764-0	2020	Global characterization of proteome and lysine methylome features in EZH2 wild-type and mutant lymphoma cell lines.	tyrosyl-lysine	40-46	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	69-73
31846764-2	2020	EZH2, a methyltransferase specifically trimethylates the lysine 27 of histone H3 and its aberrance in several cancers promotes the development of its inhibitors against hematological tumors.	tyrosyl-lysine	57-63	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
31846764-3	2020	In this study, we presented a deep exploration of lysine mono-, di- and trimethylomes in EZH2 wild-type and Y641 mutant lymphoma cell lines.	tyrosyl-lysine	50-56	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	89-93
31846764-5	2020	Moreover, these methylated lysine residues could also undergo other types of PTMs.	tyrosyl-lysine	27-33	parathymosin	Homo sapiens	77-81
31846764-8	2020	SIGNIFICANCE: Our study showed the global landscape of mono-, di- and trimethylomes in the EZH2-aberrant DLBCL cell lines, revealing the molecular characteristics of lysine methylation.	tyrosyl-lysine	166-172	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	91-95
31846764-9	2020	Combined with the protein abundance and potential crosstalk among different types of PTMs, our study raised new insights into the global cellular methylation features in hematological tumors and provided further inspects into the distribution and function of lysine methylation.	tyrosyl-lysine	259-265	parathymosin	Homo sapiens	85-89
31806371-1	2020	Lysine-specific demethylase 1 (LSD1) is a well characterized transcriptional regulator functioning on the chromatin to remove mono- and di-methyl groups from lysine 4 or lysine 9 of histone 3 (H3K4 or H3K9).	tyrosyl-lysine	158-164	lysine (K)-specific demethylase 1A	Mus musculus	31-35
31806371-1	2020	Lysine-specific demethylase 1 (LSD1) is a well characterized transcriptional regulator functioning on the chromatin to remove mono- and di-methyl groups from lysine 4 or lysine 9 of histone 3 (H3K4 or H3K9).	tyrosyl-lysine	170-176	lysine (K)-specific demethylase 1A	Mus musculus	0-29
31806371-1	2020	Lysine-specific demethylase 1 (LSD1) is a well characterized transcriptional regulator functioning on the chromatin to remove mono- and di-methyl groups from lysine 4 or lysine 9 of histone 3 (H3K4 or H3K9).	tyrosyl-lysine	170-176	lysine (K)-specific demethylase 1A	Mus musculus	31-35
32003988-1	2020	Mono-ubiquitination at Lysine 119 of H2A (ubH2A) is a prevalent post-translational modification and associated with gene repression in the context of chromatin.	tyrosyl-lysine	23-29	H2A clustered histone 18	Homo sapiens	37-40
32075761-3	2020	NaV1.5 is SUMOylated only on lysine 442, and the mutation of that residue, or application of a deSUMOylating enzyme, prevents hypoxic reopenings.	tyrosyl-lysine	29-35	sodium voltage-gated channel alpha subunit 5	Homo sapiens	0-6
32047038-5	2020	IP6 binds to a cognate pocket formed by conserved lysine residues from CSN2 and Rbx1/Roc1, thereby strengthening CRL-CSN interactions to dislodge the E2 CDC34/UBE2R from CRL and to promote CRL deneddylation.	tyrosyl-lysine	50-56	casein beta	Mus musculus	71-75
32009391-0	2020	Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.	tyrosyl-lysine	85-91	heat shock protein 90 alpha family class A member 1	Homo sapiens	95-100
32009391-3	2020	Here, we employ an alternative approach for increasing kinact of a lysine-targeted covalent Hsp90 inhibitor, independent of the reversible binding affinity (Ki) or the intrinsic electrophilicity.	tyrosyl-lysine	67-73	heat shock protein 90 alpha family class A member 1	Homo sapiens	92-97
31880908-6	2020	Three lysine residues (K6, K9, and K15) within Nt17 can be SUMOylated, which modifies htt"s accumulation and toxicity within cells in a variety of HD models.	tyrosyl-lysine	6-12	huntingtin	Homo sapiens	86-89
32070414-3	2020	RESULTS: Here, we identify the lysine demethylase JMJD1B as a novel player in the maturation cascade that contributes to regulate histone provision.	tyrosyl-lysine	31-37	lysine demethylase 3B	Homo sapiens	50-56
32060227-2	2020	In this issue of Cancer Research, Liao and colleagues show that histone H3 trimethylation on lysine 27, induced by polycomb repressive complex 2 (PRC2), is responsible for downregulating FBP1 in liver and kidney cancer cells.	tyrosyl-lysine	93-99	fructose-bisphosphatase 1	Homo sapiens	187-191
31907281-7	2020	We found that five histidine residues in helices 5-8 of apoA-I are preferably cross-linked by oxPLs, forming stable pyrrole adducts with lysine residues in the helices 3-4 of another apoA-I or in the central domain of apoA-II.	tyrosyl-lysine	137-143	apolipoprotein A1	Homo sapiens	56-62
32053037-4	2021	A non-conservative substitution of lysine by alanine (K232A) was found in DGAT1 gene producing a strong effect on milk composition and yield.	tyrosyl-lysine	35-41	diacylglycerol O-acyltransferase 1	Bos taurus	74-79
32027733-3	2020	Previous studies demonstrated that lysine 63 (K63)-linked polyubiquitination of RIG-I is vital for its activation, but the mechanisms through which RIG-I is deubiquitinated to control innate immune responses are not well understood.	tyrosyl-lysine	35-41	DExD/H-box helicase 58	Homo sapiens	80-85
32027733-3	2020	Previous studies demonstrated that lysine 63 (K63)-linked polyubiquitination of RIG-I is vital for its activation, but the mechanisms through which RIG-I is deubiquitinated to control innate immune responses are not well understood.	tyrosyl-lysine	35-41	DExD/H-box helicase 58	Homo sapiens	148-153
31833203-1	2020	Histone lysine demethylase 1 (LSD1), the first identified histone demethylase, is overexpressed in multiple tumor types, including breast cancer.	tyrosyl-lysine	8-14	lysine demethylase 1A	Homo sapiens	30-34
31908141-3	2020	Mechanistically, PCAF acetylation of ISX at lysine 69 promotes the interaction with acetylated bromodomain-containing protein 4 (BRD4) at lysine 332 in tumor cells, and the translocation of the resulting complex into the nucleus.	tyrosyl-lysine	44-50	lysine acetyltransferase 2B	Homo sapiens	17-21
31908141-3	2020	Mechanistically, PCAF acetylation of ISX at lysine 69 promotes the interaction with acetylated bromodomain-containing protein 4 (BRD4) at lysine 332 in tumor cells, and the translocation of the resulting complex into the nucleus.	tyrosyl-lysine	44-50	intestine specific homeobox	Homo sapiens	37-40
31908141-3	2020	Mechanistically, PCAF acetylation of ISX at lysine 69 promotes the interaction with acetylated bromodomain-containing protein 4 (BRD4) at lysine 332 in tumor cells, and the translocation of the resulting complex into the nucleus.	tyrosyl-lysine	44-50	bromodomain containing 4	Homo sapiens	95-127
31908141-3	2020	Mechanistically, PCAF acetylation of ISX at lysine 69 promotes the interaction with acetylated bromodomain-containing protein 4 (BRD4) at lysine 332 in tumor cells, and the translocation of the resulting complex into the nucleus.	tyrosyl-lysine	44-50	bromodomain containing 4	Homo sapiens	129-133
31908141-3	2020	Mechanistically, PCAF acetylation of ISX at lysine 69 promotes the interaction with acetylated bromodomain-containing protein 4 (BRD4) at lysine 332 in tumor cells, and the translocation of the resulting complex into the nucleus.	tyrosyl-lysine	138-144	lysine acetyltransferase 2B	Homo sapiens	17-21
31908141-3	2020	Mechanistically, PCAF acetylation of ISX at lysine 69 promotes the interaction with acetylated bromodomain-containing protein 4 (BRD4) at lysine 332 in tumor cells, and the translocation of the resulting complex into the nucleus.	tyrosyl-lysine	138-144	intestine specific homeobox	Homo sapiens	37-40
31908141-3	2020	Mechanistically, PCAF acetylation of ISX at lysine 69 promotes the interaction with acetylated bromodomain-containing protein 4 (BRD4) at lysine 332 in tumor cells, and the translocation of the resulting complex into the nucleus.	tyrosyl-lysine	138-144	bromodomain containing 4	Homo sapiens	95-127
31908141-3	2020	Mechanistically, PCAF acetylation of ISX at lysine 69 promotes the interaction with acetylated bromodomain-containing protein 4 (BRD4) at lysine 332 in tumor cells, and the translocation of the resulting complex into the nucleus.	tyrosyl-lysine	138-144	bromodomain containing 4	Homo sapiens	129-133
31813799-6	2020	Importantly, ZFAT-AS1 could inhibit CDX2 transcription by mediating the methylation of histone H3 on lysine 27 (H3K27me3) modification induced by PRC2 in the CDX2 promoter region.	tyrosyl-lysine	101-107	ZFAT antisense RNA 1	Homo sapiens	13-21
31813799-6	2020	Importantly, ZFAT-AS1 could inhibit CDX2 transcription by mediating the methylation of histone H3 on lysine 27 (H3K27me3) modification induced by PRC2 in the CDX2 promoter region.	tyrosyl-lysine	101-107	caudal type homeobox 2	Homo sapiens	36-40
31813799-6	2020	Importantly, ZFAT-AS1 could inhibit CDX2 transcription by mediating the methylation of histone H3 on lysine 27 (H3K27me3) modification induced by PRC2 in the CDX2 promoter region.	tyrosyl-lysine	101-107	caudal type homeobox 2	Homo sapiens	158-162
31896304-10	2020	Proteomics analysis and in vitro screening revealed that Drp1 acetylation at lysine 642 (K642) was increased by HFD in mouse hearts and by palmitate incubation in cardiomyocytes.	tyrosyl-lysine	77-83	dynamin 1-like	Mus musculus	57-61
31985200-1	2020	Human lysine demethylase KDM5A is a chromatin modifying enzyme associated with transcriptional regulation due to its ability to catalyze removal of methyl groups from methylated lysine 4 of histone H3 (H3K4me3).	tyrosyl-lysine	6-12	lysine demethylase 5A	Homo sapiens	25-30
31985200-1	2020	Human lysine demethylase KDM5A is a chromatin modifying enzyme associated with transcriptional regulation due to its ability to catalyze removal of methyl groups from methylated lysine 4 of histone H3 (H3K4me3).	tyrosyl-lysine	6-12	relaxin 3	Homo sapiens	202-209
31985200-1	2020	Human lysine demethylase KDM5A is a chromatin modifying enzyme associated with transcriptional regulation due to its ability to catalyze removal of methyl groups from methylated lysine 4 of histone H3 (H3K4me3).	tyrosyl-lysine	178-184	lysine demethylase 5A	Homo sapiens	25-30
31985200-1	2020	Human lysine demethylase KDM5A is a chromatin modifying enzyme associated with transcriptional regulation due to its ability to catalyze removal of methyl groups from methylated lysine 4 of histone H3 (H3K4me3).	tyrosyl-lysine	178-184	relaxin 3	Homo sapiens	202-209
32041641-1	2020	BACKGROUND: Pathogenic variants of the lysine acetyltransferase 6A or KAT6A gene are associated with a newly identified neurodevelopmental disorder characterized mainly by intellectual disability of variable severity and speech delay, hypotonia, and heart and eye malformations.	tyrosyl-lysine	39-45	lysine acetyltransferase 6A	Homo sapiens	70-75
31599107-3	2020	Histone methyltransferase Enhancer of Zeste homolog 2 (EZH2) is a catalytic subunit of Polycomb Repressive Complex 2, and is able to catalyze tri-methylation of histone H3 at lysine 27 to silence its target genes (2).	tyrosyl-lysine	175-181	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	26-53
31599107-3	2020	Histone methyltransferase Enhancer of Zeste homolog 2 (EZH2) is a catalytic subunit of Polycomb Repressive Complex 2, and is able to catalyze tri-methylation of histone H3 at lysine 27 to silence its target genes (2).	tyrosyl-lysine	175-181	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	55-59
31593685-0	2020	Extracellular lysine 38 plays a crucial role in pH-dependent transport via human monocarboxylate transporter 1.	tyrosyl-lysine	14-20	solute carrier family 16 member 1	Homo sapiens	81-110
31593685-6	2020	Since DEPC, PGO, and DIDS are membrane impermeable reagents, we mutated to other residues individual histidine, arginine, and lysine residues located within the extracellular regions of hMCT1.	tyrosyl-lysine	126-132	solute carrier family 16 member 1	Homo sapiens	186-191
31744379-4	2020	During this 2-step process, the ER transmembrane E3 ligase TRIM13 undergoes auto-ubiquitination via lysine 63 (K63) linkage chains and acts as a ligand for the autophagic receptor SQSTM1/p62 (sequestosome 1).	tyrosyl-lysine	100-106	tripartite motif containing 13	Homo sapiens	59-65
31744379-4	2020	During this 2-step process, the ER transmembrane E3 ligase TRIM13 undergoes auto-ubiquitination via lysine 63 (K63) linkage chains and acts as a ligand for the autophagic receptor SQSTM1/p62 (sequestosome 1).	tyrosyl-lysine	100-106	sequestosome 1	Homo sapiens	180-186
31744379-4	2020	During this 2-step process, the ER transmembrane E3 ligase TRIM13 undergoes auto-ubiquitination via lysine 63 (K63) linkage chains and acts as a ligand for the autophagic receptor SQSTM1/p62 (sequestosome 1).	tyrosyl-lysine	100-106	sequestosome 1	Homo sapiens	187-190
31751593-2	2020	SET7/9, a protein lysine methyltransferase, catalyses methylation of several proteins involved in diverse biological processes.	tyrosyl-lysine	18-24	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
31751593-8	2020	Importantly, we identified that SET7/9 methylates eL42 at three different lysines - Lys53, Lys80 and Lys100 through site-directed mutagenesis.	tyrosyl-lysine	74-81	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	32-38
31751593-10	2020	This study identifies a new role of the functionally versatile SET7/9 lysine methyltransferase in the regulation of global protein synthesis.	tyrosyl-lysine	70-76	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	63-69
31776131-0	2020	Histone Lysine Methylation Dynamics Control EGFR DNA Copy Number Amplification.	tyrosyl-lysine	8-14	epidermal growth factor receptor	Homo sapiens	44-48
31776131-3	2020	In this study, we reveal a critical interplay between a myriad of lysine methyltransferases and demethylases in modulating H3K4/9/27 methylation balance in order to control extrachromosomal amplification of the EGFR oncogene.	tyrosyl-lysine	66-72	epidermal growth factor receptor	Homo sapiens	211-215
31840352-1	2020	OBJECTIVES: Mixed lineage leukaemia protein-1 (MLL1) mediates histone 3 lysine 4 (H3K4) trimethylation (me3) and plays vital roles during early embryonic development and hematopoiesis.	tyrosyl-lysine	72-78	lysine (K)-specific methyltransferase 2A	Mus musculus	12-45
31840352-1	2020	OBJECTIVES: Mixed lineage leukaemia protein-1 (MLL1) mediates histone 3 lysine 4 (H3K4) trimethylation (me3) and plays vital roles during early embryonic development and hematopoiesis.	tyrosyl-lysine	72-78	lysine (K)-specific methyltransferase 2A	Mus musculus	47-51
31961032-1	2020	The jumonji domain-containing protein 6 (JMJD6) is a Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of histone and non-histone peptides.	tyrosyl-lysine	121-127	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	4-39
31961032-1	2020	The jumonji domain-containing protein 6 (JMJD6) is a Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of histone and non-histone peptides.	tyrosyl-lysine	121-127	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	41-46
32025238-7	2020	Also, EZH2 regulated the expression of NOX4 in NP cells through the histone H3 lysine 27 trimethylation (H3K27me3) in the promoter of NOX4 gene.	tyrosyl-lysine	79-85	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	6-10
32025238-7	2020	Also, EZH2 regulated the expression of NOX4 in NP cells through the histone H3 lysine 27 trimethylation (H3K27me3) in the promoter of NOX4 gene.	tyrosyl-lysine	79-85	NADPH oxidase 4	Rattus norvegicus	39-43
32025238-7	2020	Also, EZH2 regulated the expression of NOX4 in NP cells through the histone H3 lysine 27 trimethylation (H3K27me3) in the promoter of NOX4 gene.	tyrosyl-lysine	79-85	NADPH oxidase 4	Rattus norvegicus	134-138
32007477-0	2020	Histone lysine demethylase KDM5B maintains chronic myeloid leukemia via multiple epigenetic actions.	tyrosyl-lysine	8-14	lysine demethylase 5B	Homo sapiens	27-32
31887396-4	2020	Additionally, we also found that histone 3 lysine 9 acetylation (H3K9ac) and H3K27ac levels in the promoter region of angiotensin-converting enzyme (ACE) were increased in female offspring exposed to ethanol during pregnancy.	tyrosyl-lysine	43-49	angiotensin I converting enzyme	Rattus norvegicus	118-147
31887396-4	2020	Additionally, we also found that histone 3 lysine 9 acetylation (H3K9ac) and H3K27ac levels in the promoter region of angiotensin-converting enzyme (ACE) were increased in female offspring exposed to ethanol during pregnancy.	tyrosyl-lysine	43-49	angiotensin I converting enzyme	Rattus norvegicus	149-152
31829803-0	2020	Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin.	tyrosyl-lysine	27-33	titin	Mus musculus	109-114
31829803-8	2020	Exercise changed the acetylation levels of 33 lysine sites of titin, whereas Scriptaid changed acetylation levels of 31 titin lysine sites.	tyrosyl-lysine	46-52	titin	Mus musculus	62-67
31829803-8	2020	Exercise changed the acetylation levels of 33 lysine sites of titin, whereas Scriptaid changed acetylation levels of 31 titin lysine sites.	tyrosyl-lysine	126-132	titin	Mus musculus	120-125
31709617-9	2020	Mechanistcally, EIF3J-AS1 was upregulated by cAMP-response element-binding protein-binding protein-mediated histone H3 on lysine 27 acetylation (H3K27ac) at the promoter region, and EIF3J-AS1 upregulated YAP1 expression through sponging miR-3163 in CRC cells.	tyrosyl-lysine	122-128	EIF3J divergent transcript	Homo sapiens	16-25
31897776-2	2020	Herein, we report the case of a girl, presenting at 2 years of age with lymphocytosis and splenomegaly in whom a novel, in-frame, three base pair deletion in CARD11 was identified resulting in the deletion of a single lysine residue (K215del) from the coiled-coil domain.	tyrosyl-lysine	218-224	caspase recruitment domain family member 11	Homo sapiens	158-164
31604180-13	2020	The 20-35% prolongation of lysis-times caused by all polyphosphates was a kringle-dependent phenomenon, and was dampened in the presence of 6-aminohexanoate blocking the lysine-binding sites of plasmin.	tyrosyl-lysine	170-176	plasminogen	Homo sapiens	194-201
31882173-3	2020	Mass spectrometry of extracellular YB-1 in sera from patients with SLE and lupus-prone mice revealed specific post-translational guanidinylation of two lysine residues within the highly conserved cold-shock domain of YB-1 (YB-1-G).	tyrosyl-lysine	152-158	Y-box binding protein 1	Homo sapiens	35-39
31882173-3	2020	Mass spectrometry of extracellular YB-1 in sera from patients with SLE and lupus-prone mice revealed specific post-translational guanidinylation of two lysine residues within the highly conserved cold-shock domain of YB-1 (YB-1-G).	tyrosyl-lysine	152-158	Y box protein 1	Mus musculus	217-221
31765768-3	2020	Here, recombinant Prx5-Grx was confirmed as a plasminogen (Plg)-binding protein, in an interaction which could be inhibited by the lysine analogue epsilon-aminocapronic acid.	tyrosyl-lysine	131-137	glutaredoxin	Rattus norvegicus	18-26
31765768-4	2020	rPrx5-Grx derivatives bearing a substituted C-terminal lysine residue (rPrx5-GrxK244A), but not the active site cysteine residue (rPrx5-GrxC185A) or the sub-terminal rPrx5-GrxK230A lysine residue, exhibited significantly reduced Plg-binding.	tyrosyl-lysine	55-61	glutaredoxin	Rattus norvegicus	0-9
31765768-4	2020	rPrx5-Grx derivatives bearing a substituted C-terminal lysine residue (rPrx5-GrxK244A), but not the active site cysteine residue (rPrx5-GrxC185A) or the sub-terminal rPrx5-GrxK230A lysine residue, exhibited significantly reduced Plg-binding.	tyrosyl-lysine	181-187	glutaredoxin	Rattus norvegicus	0-9
31707632-5	2020	We show that Tg(PrP3K3A)/Prnp0/0 mice were highly resistant to the prions, indicating that lysine residues at 23, 24, and 27 could be important for the polybasic region to support prion infection.	tyrosyl-lysine	91-97	prion protein	Mus musculus	25-29
31789407-1	2020	Rearrangement of the mixed lineage leukemia (MLL; also known as lysine methyltransferase 2A) gene is a recurrent genomic aberration in acute myeloid leukemia (AML).	tyrosyl-lysine	64-70	lysine (K)-specific methyltransferase 2A	Mus musculus	45-48
31819273-1	2020	The enhancer of zeste homolog 2 (EZH2) is the main enzymatic subunit of the PRC2 complex, which catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) to promote transcriptional silencing.	tyrosyl-lysine	135-141	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	4-31
31819273-1	2020	The enhancer of zeste homolog 2 (EZH2) is the main enzymatic subunit of the PRC2 complex, which catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) to promote transcriptional silencing.	tyrosyl-lysine	135-141	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-37
31913353-6	2020	Deletion of ARID1A resulted in loss of histone deacetylase 1 binding, increased histone 4 lysine acetylation and subsequent BRD4-driven transcription and growth.	tyrosyl-lysine	90-96	AT-rich interaction domain 1A	Homo sapiens	12-18
32004955-1	2020	The yeast peroxiredoxin Ahp1, like related anti-oxidant enzymes in other species, undergoes urmylation, a lysine-directed conjugation to ubiquitin-like modifier Urm1.	tyrosyl-lysine	106-112	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	24-28
32004955-1	2020	The yeast peroxiredoxin Ahp1, like related anti-oxidant enzymes in other species, undergoes urmylation, a lysine-directed conjugation to ubiquitin-like modifier Urm1.	tyrosyl-lysine	106-112	ubiquitin-related modifier URM1	Saccharomyces cerevisiae S288C	161-165
32004955-6	2020	Moreover, Ahp1 urmylation involves at least two lysine residues close to the catalytic cysteines and can be prevented in yeast cells exposed to high organic peroxide concentrations.	tyrosyl-lysine	48-54	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	10-14
31767635-1	2020	HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac), but is dispensable for H4 acetylation and DNA replication in mouse tissues.	tyrosyl-lysine	45-51	K(lysine) acetyltransferase 7	Mus musculus	0-4
31767635-1	2020	HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac), but is dispensable for H4 acetylation and DNA replication in mouse tissues.	tyrosyl-lysine	45-51	K(lysine) acetyltransferase 7	Mus musculus	6-11
31767635-1	2020	HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac), but is dispensable for H4 acetylation and DNA replication in mouse tissues.	tyrosyl-lysine	45-51	K(lysine) acetyltransferase 7	Mus musculus	12-16
32013195-0	2020	Characterization of Lysine Acetyltransferase Activity of Recombinant Human ARD1/NAA10.	tyrosyl-lysine	20-26	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	75-79
32013195-0	2020	Characterization of Lysine Acetyltransferase Activity of Recombinant Human ARD1/NAA10.	tyrosyl-lysine	20-26	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	80-85
32013195-2	2020	After that, mammalian ARD1/NAA10 expanded its" role to lysine acetyltransferase (KAT) that post-translationally acetylates internal lysine residues of proteins.	tyrosyl-lysine	55-61	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	22-26
32013195-2	2020	After that, mammalian ARD1/NAA10 expanded its" role to lysine acetyltransferase (KAT) that post-translationally acetylates internal lysine residues of proteins.	tyrosyl-lysine	55-61	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	27-32
32013195-2	2020	After that, mammalian ARD1/NAA10 expanded its" role to lysine acetyltransferase (KAT) that post-translationally acetylates internal lysine residues of proteins.	tyrosyl-lysine	55-61	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	81-84
32013195-2	2020	After that, mammalian ARD1/NAA10 expanded its" role to lysine acetyltransferase (KAT) that post-translationally acetylates internal lysine residues of proteins.	tyrosyl-lysine	132-138	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	22-26
32013195-2	2020	After that, mammalian ARD1/NAA10 expanded its" role to lysine acetyltransferase (KAT) that post-translationally acetylates internal lysine residues of proteins.	tyrosyl-lysine	132-138	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	27-32
32013195-2	2020	After that, mammalian ARD1/NAA10 expanded its" role to lysine acetyltransferase (KAT) that post-translationally acetylates internal lysine residues of proteins.	tyrosyl-lysine	132-138	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	81-84
32013195-4	2020	However, recent studies on the role of human ARD1/NAA10 (hARD1/NAA10) in lysine acetylation are contradictory, as crystal structure and in vitro acetylation assay results revealed the lack of KAT activity.	tyrosyl-lysine	73-79	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	45-49
32013195-4	2020	However, recent studies on the role of human ARD1/NAA10 (hARD1/NAA10) in lysine acetylation are contradictory, as crystal structure and in vitro acetylation assay results revealed the lack of KAT activity.	tyrosyl-lysine	73-79	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	50-55
32013195-4	2020	However, recent studies on the role of human ARD1/NAA10 (hARD1/NAA10) in lysine acetylation are contradictory, as crystal structure and in vitro acetylation assay results revealed the lack of KAT activity.	tyrosyl-lysine	73-79	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	57-62
32013195-4	2020	However, recent studies on the role of human ARD1/NAA10 (hARD1/NAA10) in lysine acetylation are contradictory, as crystal structure and in vitro acetylation assay results revealed the lack of KAT activity.	tyrosyl-lysine	73-79	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	63-68
32013195-5	2020	Thus, the role of hARD1/NAA10 in lysine acetylation is still debating.	tyrosyl-lysine	33-39	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	18-23
32013195-5	2020	Thus, the role of hARD1/NAA10 in lysine acetylation is still debating.	tyrosyl-lysine	33-39	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	24-29
32013195-9	2020	While oligomeric recombinant hARD1/NAA10 lost its ability for lysine acetylation, its monomeric form clearly exhibited lysine acetylation activity in vitro.	tyrosyl-lysine	62-68	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	29-34
32013195-9	2020	While oligomeric recombinant hARD1/NAA10 lost its ability for lysine acetylation, its monomeric form clearly exhibited lysine acetylation activity in vitro.	tyrosyl-lysine	62-68	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	35-40
32013195-9	2020	While oligomeric recombinant hARD1/NAA10 lost its ability for lysine acetylation, its monomeric form clearly exhibited lysine acetylation activity in vitro.	tyrosyl-lysine	119-125	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	29-34
32047753-2	2019	Indoleamine 2, 3-dioxygenase 1 (IDO1) catalyzes the conversion of tryptophan to kynurenine causing lysine depletion, which is an important target in the research and development of anticancer drugs.	tyrosyl-lysine	99-105	indoleamine 2,3-dioxygenase 1	Homo sapiens	0-30
32047753-2	2019	Indoleamine 2, 3-dioxygenase 1 (IDO1) catalyzes the conversion of tryptophan to kynurenine causing lysine depletion, which is an important target in the research and development of anticancer drugs.	tyrosyl-lysine	99-105	indoleamine 2,3-dioxygenase 1	Homo sapiens	32-36
31799602-3	2020	The histone code model proposes that HP1alpha forms and maintains these domains of heterochromatin through the interaction of its chromodomain with trimethylated lysine 9 of histone 3, although this interaction is not the sole determinant.	tyrosyl-lysine	162-168	chromobox 5	Homo sapiens	37-45
31973069-3	2020	Here, we examined the interaction of neuronal calcium sensor-1 (NCS-1) with natural membranes of different lipid composition as well as individual phospholipids in form of multilamellar liposomes or immobilized monolayers and characterized the role of myristoyl group and N-terminal lysine residues in membrane binding and phospholipid preference of the protein.	tyrosyl-lysine	283-289	neuronal calcium sensor 1	Homo sapiens	64-69
32010779-1	2020	Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23).	tyrosyl-lysine	0-6	K(lysine) acetyltransferase 6A	Mus musculus	29-34
32010779-1	2020	Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23).	tyrosyl-lysine	0-6	K(lysine) acetyltransferase 6B	Mus musculus	52-57
32010779-1	2020	Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23).	tyrosyl-lysine	0-6	bromodomain and PHD finger containing, 1	Mus musculus	93-141
32010779-1	2020	Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23).	tyrosyl-lysine	0-6	bromodomain and PHD finger containing, 1	Mus musculus	143-148
32010779-1	2020	Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23).	tyrosyl-lysine	183-189	K(lysine) acetyltransferase 6A	Mus musculus	29-34
32010779-1	2020	Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23).	tyrosyl-lysine	183-189	K(lysine) acetyltransferase 6B	Mus musculus	52-57
32010779-1	2020	Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23).	tyrosyl-lysine	183-189	bromodomain and PHD finger containing, 1	Mus musculus	93-141
32010779-1	2020	Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23).	tyrosyl-lysine	183-189	bromodomain and PHD finger containing, 1	Mus musculus	143-148
32021450-1	2020	Background: Nuclear receptor suppressor of variegation, enhancer of zeste, and trithorax (SET) domain-containing 2 (NSD2), is a well-known histone lysine methyltransferase (HMTase).	tyrosyl-lysine	147-153	nuclear receptor binding SET domain protein 2	Homo sapiens	116-120
31612581-0	2020	Analysis of the substrate specificity of the SMYD2 protein lysine methyltransferase and discovery of novel non-histone substrates.	tyrosyl-lysine	59-65	SET and MYND domain containing 2	Homo sapiens	45-50
31612581-1	2020	The SMYD2 protein lysine methyltransferase methylates different histone and non-histone proteins and it is overexpressed in several cancers.	tyrosyl-lysine	18-24	SET and MYND domain containing 2	Homo sapiens	4-9
31612581-4	2020	Among them, 19 were already reported to be methylated at the target lysine in human cells, strongly suggesting that SMYD2 is the PKMT responsible for this activity.	tyrosyl-lysine	68-74	SET and MYND domain containing 2	Homo sapiens	116-121
31782544-4	2020	We showed that subtle chromatin binding changes in differentiated cells translate into activation of the histone H3 lysine 9 (H3K9) methyltransferase Ehmt1 and stabilization of the zinc finger TF Zic2 at enhancers and promoters.	tyrosyl-lysine	116-122	euchromatic histone methyltransferase 1	Mus musculus	150-155
31813957-3	2020	The major cause of Kabuki syndrome are mutations in KMT2D, a gene encoding a histone H3 lysine 4 (H3K4) methyltransferase belonging to the group of chromatin modifiers.	tyrosyl-lysine	88-96	lysine methyltransferase 2D	Homo sapiens	52-57
31941883-5	2020	As a consequence, lysine codons in proinsulin are misread and proinsulin processing is impaired, reducing insulin content and secretion.	tyrosyl-lysine	18-24	insulin	Homo sapiens	35-45
31941883-5	2020	As a consequence, lysine codons in proinsulin are misread and proinsulin processing is impaired, reducing insulin content and secretion.	tyrosyl-lysine	18-24	insulin	Homo sapiens	38-45
31941883-6	2020	Iron normalizes ms2t6A37 and proinsulin lysine incorporation, restoring insulin content and secretion in Irp2-/- beta cells.	tyrosyl-lysine	40-46	insulin	Homo sapiens	29-39
31941883-6	2020	Iron normalizes ms2t6A37 and proinsulin lysine incorporation, restoring insulin content and secretion in Irp2-/- beta cells.	tyrosyl-lysine	40-46	insulin	Homo sapiens	32-39
31967103-5	2020	When cells that carried a polycomb-repressed transgene (luciferase) were treated with UNC1999 or the AAP fusion Gal4P65, we observed loss of histone 3 lysine 27 trimethylation (H3K27me3), a silencing-associated chromatin feature, at the transgene.	tyrosyl-lysine	151-157	serpin family F member 2	Homo sapiens	101-104
32021283-1	2020	Background: Mixed lineage leukemia (MLL) fusion protein alone exhibits poor histone lysine methyltransferase (HKMT) activity in catalyzing histone H3 Lys4 trimethylation (H3K4me3) in MLL-rearranged acute leukemia.	tyrosyl-lysine	84-90	lysine methyltransferase 2A	Homo sapiens	36-39
31924266-1	2020	The type 2 lysine methyltransferases KMT2C and KMT2D are large, enzymatically active scaffold proteins that form the core of nuclear regulatory structures known as KMT2C/D COMPASS complexes (complex of proteins associating with Set1).	tyrosyl-lysine	11-17	lysine methyltransferase 2C	Homo sapiens	37-42
31924266-1	2020	The type 2 lysine methyltransferases KMT2C and KMT2D are large, enzymatically active scaffold proteins that form the core of nuclear regulatory structures known as KMT2C/D COMPASS complexes (complex of proteins associating with Set1).	tyrosyl-lysine	11-17	lysine methyltransferase 2D	Homo sapiens	47-52
31924266-1	2020	The type 2 lysine methyltransferases KMT2C and KMT2D are large, enzymatically active scaffold proteins that form the core of nuclear regulatory structures known as KMT2C/D COMPASS complexes (complex of proteins associating with Set1).	tyrosyl-lysine	11-17	lysine methyltransferase 2C	Homo sapiens	164-169
31924266-1	2020	The type 2 lysine methyltransferases KMT2C and KMT2D are large, enzymatically active scaffold proteins that form the core of nuclear regulatory structures known as KMT2C/D COMPASS complexes (complex of proteins associating with Set1).	tyrosyl-lysine	11-17	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	228-232
31982102-0	2020	Demethylation of Di-Methylation of Lysine 4 on Histone 3 Is Inhibited by General Control Nondepressible 5-Induced Acetylation of Lysine-Specific Demethylase 1.	tyrosyl-lysine	35-41	lysine acetyltransferase 2A	Homo sapiens	73-105
31982102-0	2020	Demethylation of Di-Methylation of Lysine 4 on Histone 3 Is Inhibited by General Control Nondepressible 5-Induced Acetylation of Lysine-Specific Demethylase 1.	tyrosyl-lysine	35-41	lysine demethylase 1A	Homo sapiens	129-158
31982102-1	2020	BACKGROUND: Histone demethylase lysine-specific demethylase 1 (LSD1) potentiates cancer progression through inducing demethylation of di-methylation of lysine 4 on histone 3.	tyrosyl-lysine	32-38	lysine demethylase 1A	Homo sapiens	63-67
31982102-9	2020	GCN5 induced the acetylation of LSD1 at lysine 433 site.	tyrosyl-lysine	40-46	lysine acetyltransferase 2A	Homo sapiens	0-4
31982102-9	2020	GCN5 induced the acetylation of LSD1 at lysine 433 site.	tyrosyl-lysine	40-46	lysine demethylase 1A	Homo sapiens	32-36
31871199-0	2020	Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself.	tyrosyl-lysine	71-77	inverted formin 2	Homo sapiens	14-18
31871199-3	2020	We recently showed that INF2 uses a variant of this mechanism that we term "facilitated autoinhibition," whereby a complex consisting of cyclase-associated protein (CAP) bound to lysine-acetylated actin (KAc-actin) is required for INF2 inhibition, in a manner requiring INF2-DID.	tyrosyl-lysine	179-185	inverted formin 2	Homo sapiens	24-28
31871199-3	2020	We recently showed that INF2 uses a variant of this mechanism that we term "facilitated autoinhibition," whereby a complex consisting of cyclase-associated protein (CAP) bound to lysine-acetylated actin (KAc-actin) is required for INF2 inhibition, in a manner requiring INF2-DID.	tyrosyl-lysine	179-185	inverted formin 2	Homo sapiens	231-235
31871199-3	2020	We recently showed that INF2 uses a variant of this mechanism that we term "facilitated autoinhibition," whereby a complex consisting of cyclase-associated protein (CAP) bound to lysine-acetylated actin (KAc-actin) is required for INF2 inhibition, in a manner requiring INF2-DID.	tyrosyl-lysine	179-185	inverted formin 2	Homo sapiens	231-235
31871199-5	2020	Here we use lysine-to-glutamine mutations as acetylmimetics to map the relevant lysines on actin for INF2 regulation, focusing on K50, K61, and K328.	tyrosyl-lysine	12-18	inverted formin 2	Homo sapiens	101-105
31871199-5	2020	Here we use lysine-to-glutamine mutations as acetylmimetics to map the relevant lysines on actin for INF2 regulation, focusing on K50, K61, and K328.	tyrosyl-lysine	80-87	inverted formin 2	Homo sapiens	101-105
31935919-1	2020	SMYD3 is a member of the SMYD lysine methylase family and plays an important role in the methylation of various histone and non-histone targets.	tyrosyl-lysine	30-36	SET and MYND domain containing 3	Homo sapiens	0-5
31851326-6	2020	The interaction between PQLC2 and the C9orf72 complex is negatively regulated by arginine, lysine, and histidine, the amino acids that PQLC2 transports across the membrane of lysosomes.	tyrosyl-lysine	91-97	solute carrier family 66 member 1	Homo sapiens	24-29
31851326-6	2020	The interaction between PQLC2 and the C9orf72 complex is negatively regulated by arginine, lysine, and histidine, the amino acids that PQLC2 transports across the membrane of lysosomes.	tyrosyl-lysine	91-97	C9orf72-SMCR8 complex subunit	Homo sapiens	38-45
31906970-3	2020	Previously, we reported that lysine acetyltransferase p300/CBP acetylates tau and regulates its degradation and toxicity.	tyrosyl-lysine	29-35	E1A binding protein p300	Mus musculus	54-58
31906970-3	2020	Previously, we reported that lysine acetyltransferase p300/CBP acetylates tau and regulates its degradation and toxicity.	tyrosyl-lysine	29-35	CREB binding protein	Mus musculus	59-62
31906970-11	2020	CONCLUSIONS: We report that p300/CBP, a lysine acetyltransferase aberrantly activated in tauopathies, causes impairment in ALP, leading to excess tau secretion.	tyrosyl-lysine	40-46	E1A binding protein p300	Mus musculus	28-32
31906970-11	2020	CONCLUSIONS: We report that p300/CBP, a lysine acetyltransferase aberrantly activated in tauopathies, causes impairment in ALP, leading to excess tau secretion.	tyrosyl-lysine	40-46	CREB binding protein	Mus musculus	33-36
31685550-0	2020	Function of the MYND domain and C-terminal region in regulating the subcellular localization and catalytic activity of the SMYD family lysine methyltransferase Set5.	tyrosyl-lysine	135-141	S-adenosylmethionine-dependent methyltransferase	Saccharomyces cerevisiae S288C	160-164
31685550-4	2020	Set5 is a histone H4 lysine 5, 8, and 12 methyltransferase, implicated in the regulation of stress responses and genome stability.	tyrosyl-lysine	21-27	S-adenosylmethionine-dependent methyltransferase	Saccharomyces cerevisiae S288C	0-4
31706164-3	2020	Functional analysis of the genotype-associated differences in amino acid sequence and the reciprocal mutation experiments in transient-transfection and infection cell models revealed that HBx with asparagine (N) and glutamic acid (E) at 118-119 positions inhibited RIG-I signaling and interacted with MAVS more efficiently than that with lysine (K) and aspartic acid (D).	tyrosyl-lysine	338-344	X protein	Hepatitis B virus	188-191
31898218-2	2020	Neddylation, like ubiquitylation, is also catalyzed by an E1/E2/E3 enzyme cascade to covalently attach the ubiquitin-like molecule NEDD8 to a lysine residue of a substrate, not for degradation, but for modulation of substrate activity.	tyrosyl-lysine	142-148	small nucleolar RNA, H/ACA box 73A	Homo sapiens	58-66
31898218-2	2020	Neddylation, like ubiquitylation, is also catalyzed by an E1/E2/E3 enzyme cascade to covalently attach the ubiquitin-like molecule NEDD8 to a lysine residue of a substrate, not for degradation, but for modulation of substrate activity.	tyrosyl-lysine	142-148	NEDD8 ubiquitin like modifier	Homo sapiens	131-136
31654559-1	2020	Kabuki syndrome (KS) is a disorder of epigenetic dysregulation due to heterozygous mutations in KMT2D or KDM6A, genes encoding a lysine-specific methyltransferase or demethylase, respectively.	tyrosyl-lysine	129-135	lysine methyltransferase 2D	Homo sapiens	96-101
31654559-1	2020	Kabuki syndrome (KS) is a disorder of epigenetic dysregulation due to heterozygous mutations in KMT2D or KDM6A, genes encoding a lysine-specific methyltransferase or demethylase, respectively.	tyrosyl-lysine	129-135	lysine demethylase 6A	Homo sapiens	105-110
31619063-4	2020	AIP1B transcription in resting ECs was suppressed through epigenetic inhibition by RIF1 (Rap1-interacting factor 1)/H3K9 (histone H3 lysine 9) methyltransferase-mediated H3K9 trimethylation, and this inhibition was released by proinflammatory cytokines.	tyrosyl-lysine	133-139	DAB2 interacting protein	Homo sapiens	0-5
31619063-4	2020	AIP1B transcription in resting ECs was suppressed through epigenetic inhibition by RIF1 (Rap1-interacting factor 1)/H3K9 (histone H3 lysine 9) methyltransferase-mediated H3K9 trimethylation, and this inhibition was released by proinflammatory cytokines.	tyrosyl-lysine	133-139	replication timing regulatory factor 1	Homo sapiens	83-87
31619063-4	2020	AIP1B transcription in resting ECs was suppressed through epigenetic inhibition by RIF1 (Rap1-interacting factor 1)/H3K9 (histone H3 lysine 9) methyltransferase-mediated H3K9 trimethylation, and this inhibition was released by proinflammatory cytokines.	tyrosyl-lysine	133-139	replication timing regulatory factor 1	Homo sapiens	89-114
31653347-0	2020	Identification of glycated and acetylated lysine residues in human alpha2-antiplasmin.	tyrosyl-lysine	42-48	serpin family F member 2	Homo sapiens	67-85
31653347-2	2020	alpha2-antiplasmin, a key inhibitor of fibrinolysis, contains 19 lysine residues.	tyrosyl-lysine	65-71	serpin family F member 2	Homo sapiens	0-18
31653347-3	2020	AIM: We sought to identify sites of glycation and acetylation in human alpha2-antiplasmin and test whether the competition might occur on the lysine residues of alpha2-antiplasmin.	tyrosyl-lysine	142-148	serpin family F member 2	Homo sapiens	161-179
31653347-6	2020	Incubation with beta-d-glucose was associated with glycation of 4 (K-418, K-427, K-434, K-441) out of 6 lysine residues, known to be important for mediating the interaction with plasmin.	tyrosyl-lysine	104-110	plasminogen	Homo sapiens	178-185
31676296-3	2020	METHODS: Various point mutants of focal adhesion targeting (FAT) domain of Focal Adhesion Kinase (FAK) were created by moving a key Lysine residue two and three helical turns in order to match the unique conformations as observed in LDBDs of two other focal adhesion proteins, Vinculin and CCM3.	tyrosyl-lysine	132-138	protein tyrosine kinase 2	Homo sapiens	75-96
31676296-3	2020	METHODS: Various point mutants of focal adhesion targeting (FAT) domain of Focal Adhesion Kinase (FAK) were created by moving a key Lysine residue two and three helical turns in order to match the unique conformations as observed in LDBDs of two other focal adhesion proteins, Vinculin and CCM3.	tyrosyl-lysine	132-138	protein tyrosine kinase 2	Homo sapiens	98-101
31753799-3	2020	There are five human polycomb paralog proteins (Cbx2/4/6/7/8) that use their chromodomains to recognize trimethylated lysine 27 on histone 3 (H3K27me3).	tyrosyl-lysine	118-124	chromobox 2	Homo sapiens	48-60
31595041-3	2020	Here we show that ribosome stalling during protein translocation induces the attachment of UFM1, a ubiquitin-like modifier, to two conserved lysine residues near the COOH-terminus of the 60S ribosomal subunit RPL26 (uL24) at the ER.	tyrosyl-lysine	141-147	ubiquitin fold modifier 1	Homo sapiens	91-95
31595041-3	2020	Here we show that ribosome stalling during protein translocation induces the attachment of UFM1, a ubiquitin-like modifier, to two conserved lysine residues near the COOH-terminus of the 60S ribosomal subunit RPL26 (uL24) at the ER.	tyrosyl-lysine	141-147	ribosomal protein L26	Homo sapiens	209-214
31737960-0	2020	Inhibition of lysine-specific demethylase 1A suppresses neointimal hyperplasia by targeting bone morphogenetic protein 2 and mediating vascular smooth muscle cell phenotype.	tyrosyl-lysine	14-20	bone morphogenetic protein 2	Homo sapiens	92-120
31685780-2	2020	Among the three core subunits (EZH2, EED and SUZ12) of PRC2, EZH2 is the catalytic subunit that methylates histone H3 lysine 27 (H3K27), while EED is the regulatory subunit.	tyrosyl-lysine	118-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	31-35
31685780-2	2020	Among the three core subunits (EZH2, EED and SUZ12) of PRC2, EZH2 is the catalytic subunit that methylates histone H3 lysine 27 (H3K27), while EED is the regulatory subunit.	tyrosyl-lysine	118-124	embryonic ectoderm development	Homo sapiens	37-40
31685780-2	2020	Among the three core subunits (EZH2, EED and SUZ12) of PRC2, EZH2 is the catalytic subunit that methylates histone H3 lysine 27 (H3K27), while EED is the regulatory subunit.	tyrosyl-lysine	118-124	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	45-50
31685780-2	2020	Among the three core subunits (EZH2, EED and SUZ12) of PRC2, EZH2 is the catalytic subunit that methylates histone H3 lysine 27 (H3K27), while EED is the regulatory subunit.	tyrosyl-lysine	118-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	61-65
31806563-8	2020	Further study showed that dioscin attenuated Skp2 phosphorylation on S72 and promoted the interaction between Skp2 and Cdh1, which eventually enhanced Skp2 lysine 48 (K48)-linked polyubiquitination and degradation.	tyrosyl-lysine	156-162	S-phase kinase associated protein 2	Homo sapiens	110-114
31806563-8	2020	Further study showed that dioscin attenuated Skp2 phosphorylation on S72 and promoted the interaction between Skp2 and Cdh1, which eventually enhanced Skp2 lysine 48 (K48)-linked polyubiquitination and degradation.	tyrosyl-lysine	156-162	cadherin 1	Homo sapiens	119-123
31806563-8	2020	Further study showed that dioscin attenuated Skp2 phosphorylation on S72 and promoted the interaction between Skp2 and Cdh1, which eventually enhanced Skp2 lysine 48 (K48)-linked polyubiquitination and degradation.	tyrosyl-lysine	156-162	S-phase kinase associated protein 2	Homo sapiens	110-114
31815566-1	2020	Introduction: The bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra-terminal (BET) family, functions as an "epigenetic reader" that binds to acetylated lysine (KAc) residues on histone tails sophisticatedly regulating chromatin structure and gene expression.	tyrosyl-lysine	181-187	bromodomain containing 4	Homo sapiens	18-50
31815566-1	2020	Introduction: The bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra-terminal (BET) family, functions as an "epigenetic reader" that binds to acetylated lysine (KAc) residues on histone tails sophisticatedly regulating chromatin structure and gene expression.	tyrosyl-lysine	181-187	bromodomain containing 4	Homo sapiens	52-56
31815566-1	2020	Introduction: The bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra-terminal (BET) family, functions as an "epigenetic reader" that binds to acetylated lysine (KAc) residues on histone tails sophisticatedly regulating chromatin structure and gene expression.	tyrosyl-lysine	181-187	delta/notch like EGF repeat containing	Homo sapiens	107-110
31914674-1	2020	Haploinsufficiency of NSD1, which dimethylates histone H3 lysine 36 (H3K36), causes Sotos syndrome (SoS), an overgrowth syndrome.	tyrosyl-lysine	58-64	nuclear receptor binding SET domain protein 1	Homo sapiens	22-26
31914674-6	2020	Chromatin immunoprecipitation-quantitative PCR (ChIP-qPCR) revealed active enhancer histone modifications at IGF2-DMR0, with high enrichment of H3K4me1 and H3 lysine 27 acetylation (H3K27ac).	tyrosyl-lysine	159-165	insulin like growth factor 2	Homo sapiens	109-113
31585917-2	2020	Here, we review currently available studies on the unique histone methyltransferase, SETD2, which is responsible for H3 lysine 36 tri-methylation (H3K36me3).	tyrosyl-lysine	120-126	PR/SET domain 9	Homo sapiens	58-83
31585917-2	2020	Here, we review currently available studies on the unique histone methyltransferase, SETD2, which is responsible for H3 lysine 36 tri-methylation (H3K36me3).	tyrosyl-lysine	120-126	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	85-90
31735087-8	2020	Then, chromatin immunoprecipitation proved that EZH2 (enhancer of zeste homolog 2) bound to the promoter of CPT1b via H3K27me3 (trimethylation of lysine 27 of histone H3) to induce CPT1b downregulation.	tyrosyl-lysine	146-152	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	48-52
31735087-8	2020	Then, chromatin immunoprecipitation proved that EZH2 (enhancer of zeste homolog 2) bound to the promoter of CPT1b via H3K27me3 (trimethylation of lysine 27 of histone H3) to induce CPT1b downregulation.	tyrosyl-lysine	146-152	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	54-81
31735087-8	2020	Then, chromatin immunoprecipitation proved that EZH2 (enhancer of zeste homolog 2) bound to the promoter of CPT1b via H3K27me3 (trimethylation of lysine 27 of histone H3) to induce CPT1b downregulation.	tyrosyl-lysine	146-152	carnitine palmitoyltransferase 1b, muscle	Mus musculus	108-113
31746377-2	2020	Snail family transcriptional repressor 1 (SNAI1) is a transcriptional repressor that recruits multiple chromatin enzymes including lysine-specific histone demethylase 1A, histone deacetylase (HDAC) 1/2, polycomb repressive complex 2, euchromatic histone lysine methyltransferase 2 and suppressor of variegation 3-9 homolog 1 to the E-cadherin promoter, thereby suppressing E-cadherin expression.	tyrosyl-lysine	131-137	snail family transcriptional repressor 1	Homo sapiens	0-40
31746377-2	2020	Snail family transcriptional repressor 1 (SNAI1) is a transcriptional repressor that recruits multiple chromatin enzymes including lysine-specific histone demethylase 1A, histone deacetylase (HDAC) 1/2, polycomb repressive complex 2, euchromatic histone lysine methyltransferase 2 and suppressor of variegation 3-9 homolog 1 to the E-cadherin promoter, thereby suppressing E-cadherin expression.	tyrosyl-lysine	131-137	snail family transcriptional repressor 1	Homo sapiens	42-47
31746377-2	2020	Snail family transcriptional repressor 1 (SNAI1) is a transcriptional repressor that recruits multiple chromatin enzymes including lysine-specific histone demethylase 1A, histone deacetylase (HDAC) 1/2, polycomb repressive complex 2, euchromatic histone lysine methyltransferase 2 and suppressor of variegation 3-9 homolog 1 to the E-cadherin promoter, thereby suppressing E-cadherin expression.	tyrosyl-lysine	131-137	SUV39H1 histone lysine methyltransferase	Homo sapiens	261-324
31746377-2	2020	Snail family transcriptional repressor 1 (SNAI1) is a transcriptional repressor that recruits multiple chromatin enzymes including lysine-specific histone demethylase 1A, histone deacetylase (HDAC) 1/2, polycomb repressive complex 2, euchromatic histone lysine methyltransferase 2 and suppressor of variegation 3-9 homolog 1 to the E-cadherin promoter, thereby suppressing E-cadherin expression.	tyrosyl-lysine	131-137	cadherin 1	Homo sapiens	332-342
31746377-2	2020	Snail family transcriptional repressor 1 (SNAI1) is a transcriptional repressor that recruits multiple chromatin enzymes including lysine-specific histone demethylase 1A, histone deacetylase (HDAC) 1/2, polycomb repressive complex 2, euchromatic histone lysine methyltransferase 2 and suppressor of variegation 3-9 homolog 1 to the E-cadherin promoter, thereby suppressing E-cadherin expression.	tyrosyl-lysine	131-137	cadherin 1	Homo sapiens	373-383
31705628-2	2020	SLC7A7 mutations cause lysinuric protein intolerance (LPI), an inherited multisystem disease characterized by low plasma levels of arginine and lysine, protein-rich food intolerance, failure to thrive, hepatosplenomegaly, osteoporosis, lung involvement, kidney failure, haematologic and immunological disorders.	tyrosyl-lysine	144-150	solute carrier family 7 member 7	Homo sapiens	0-6
31734274-2	2020	In this study, we aim to investigate the role of lysine specific demethylase (LSD1), a histone demethylase and important regulator of thermogenesis, in mediating gut microbial metabolite butyrate regulation of thermogenesis.	tyrosyl-lysine	49-55	lysine (K)-specific demethylase 1A	Mus musculus	78-82
31615908-8	2020	Notably, the histone 3 lysine 27 tri-methylation (H3K27me3) demethylase UTX was found as a key activator of LIF transcription in osteosarcoma.	tyrosyl-lysine	23-29	lysine demethylase 6A	Homo sapiens	72-75
31615908-8	2020	Notably, the histone 3 lysine 27 tri-methylation (H3K27me3) demethylase UTX was found as a key activator of LIF transcription in osteosarcoma.	tyrosyl-lysine	23-29	LIF interleukin 6 family cytokine	Homo sapiens	108-111
31615908-9	2020	The UTX inhibitor, GSK-J4, induced H3K27me3 accumulation and impaired histone 3 lysine 27 acetylation (H3K27ac) at LIF gene locus, leading to LIF signaling pathway inhibition.	tyrosyl-lysine	80-86	lysine demethylase 6A	Homo sapiens	4-7
31680191-6	2020	Specifically, lysine 370/372/373 and 381/382/386 mutations decreased p53 stability, and lysine 305 mutation reduced p53 phosphorylation level at serine 15, while lysine 120 and 164 mutations decreased p53 acetylation level at lysine 382.	tyrosyl-lysine	14-20	tumor protein p53	Homo sapiens	69-72
31680191-6	2020	Specifically, lysine 370/372/373 and 381/382/386 mutations decreased p53 stability, and lysine 305 mutation reduced p53 phosphorylation level at serine 15, while lysine 120 and 164 mutations decreased p53 acetylation level at lysine 382.	tyrosyl-lysine	88-94	tumor protein p53	Homo sapiens	116-119
31680191-6	2020	Specifically, lysine 370/372/373 and 381/382/386 mutations decreased p53 stability, and lysine 305 mutation reduced p53 phosphorylation level at serine 15, while lysine 120 and 164 mutations decreased p53 acetylation level at lysine 382.	tyrosyl-lysine	88-94	tumor protein p53	Homo sapiens	116-119
31680191-6	2020	Specifically, lysine 370/372/373 and 381/382/386 mutations decreased p53 stability, and lysine 305 mutation reduced p53 phosphorylation level at serine 15, while lysine 120 and 164 mutations decreased p53 acetylation level at lysine 382.	tyrosyl-lysine	88-94	tumor protein p53	Homo sapiens	116-119
31680191-6	2020	Specifically, lysine 370/372/373 and 381/382/386 mutations decreased p53 stability, and lysine 305 mutation reduced p53 phosphorylation level at serine 15, while lysine 120 and 164 mutations decreased p53 acetylation level at lysine 382.	tyrosyl-lysine	88-94	tumor protein p53	Homo sapiens	116-119
31680191-6	2020	Specifically, lysine 370/372/373 and 381/382/386 mutations decreased p53 stability, and lysine 305 mutation reduced p53 phosphorylation level at serine 15, while lysine 120 and 164 mutations decreased p53 acetylation level at lysine 382.	tyrosyl-lysine	88-94	tumor protein p53	Homo sapiens	116-119
31680191-6	2020	Specifically, lysine 370/372/373 and 381/382/386 mutations decreased p53 stability, and lysine 305 mutation reduced p53 phosphorylation level at serine 15, while lysine 120 and 164 mutations decreased p53 acetylation level at lysine 382.	tyrosyl-lysine	88-94	tumor protein p53	Homo sapiens	116-119
31896605-5	2020	We further found that SET Domain Bifurcated 1 (SETDB1), a histone H3 lysine 9-specific methyltransferase, hinders the function of the identified TFs.	tyrosyl-lysine	69-75	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	22-45
31896605-5	2020	We further found that SET Domain Bifurcated 1 (SETDB1), a histone H3 lysine 9-specific methyltransferase, hinders the function of the identified TFs.	tyrosyl-lysine	69-75	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	47-53
31875854-4	2020	Here we show that, in HeLa cells, nucleosomes containing the histone variant H2A.Z are enriched with histone H4 that is dimethylated on its lysine 20 residue (H4K20me2) and with bound origin-recognition complex (ORC).	tyrosyl-lysine	140-146	H2A.Z variant histone 1	Homo sapiens	77-82
31875854-5	2020	In vitro studies show that H2A.Z-containing nucleosomes bind directly to the histone lysine methyltransferase enzyme SUV420H1, promoting H4K20me2 deposition, which is in turn required for ORC1 binding.	tyrosyl-lysine	85-91	H2A.Z variant histone 1	Homo sapiens	27-32
31875854-5	2020	In vitro studies show that H2A.Z-containing nucleosomes bind directly to the histone lysine methyltransferase enzyme SUV420H1, promoting H4K20me2 deposition, which is in turn required for ORC1 binding.	tyrosyl-lysine	85-91	lysine methyltransferase 5B	Homo sapiens	117-125
31875854-5	2020	In vitro studies show that H2A.Z-containing nucleosomes bind directly to the histone lysine methyltransferase enzyme SUV420H1, promoting H4K20me2 deposition, which is in turn required for ORC1 binding.	tyrosyl-lysine	85-91	origin recognition complex subunit 1	Homo sapiens	188-192
31582835-4	2020	Histone 3 trimethylated on lysine 27 (H3K27me3), a marker of silent chromatin conformation is present at the ADGRB1 promoter, and inhibition of EZH2, the catalytic component of the Polycomb Repressive complex 2 (PRC2) that methylates H3K27, switches the gene into an active chromatin status and reactivates BAI1 expression.	tyrosyl-lysine	27-33	adhesion G protein-coupled receptor B1	Homo sapiens	109-115
31582835-4	2020	Histone 3 trimethylated on lysine 27 (H3K27me3), a marker of silent chromatin conformation is present at the ADGRB1 promoter, and inhibition of EZH2, the catalytic component of the Polycomb Repressive complex 2 (PRC2) that methylates H3K27, switches the gene into an active chromatin status and reactivates BAI1 expression.	tyrosyl-lysine	27-33	adhesion G protein-coupled receptor B1	Homo sapiens	307-311
31732704-5	2020	Tumor necrosis factor receptor associated factor 1a (TRAF1a) and TRAF1b interacted in planta with ATG13a and ATG13b and required SINAT1 and SINAT2 to ubiquitylate and degrade ATG13s in vivo Moreover, lysines K607 and K609 of ATG13a protein contributed to K48-linked ubiquitylation and destabilization, and suppression of autophagy.	tyrosyl-lysine	200-207	seven in absentia of Arabidopsis 2	Arabidopsis thaliana	140-146
31732704-5	2020	Tumor necrosis factor receptor associated factor 1a (TRAF1a) and TRAF1b interacted in planta with ATG13a and ATG13b and required SINAT1 and SINAT2 to ubiquitylate and degrade ATG13s in vivo Moreover, lysines K607 and K609 of ATG13a protein contributed to K48-linked ubiquitylation and destabilization, and suppression of autophagy.	tyrosyl-lysine	200-207	Autophagy-related protein 13	Arabidopsis thaliana	98-103
31655428-11	2020	Furthermore, PRDX3 with the lysine residue K253 mutated to arginine (K253R) increased its dimerization in Caco-2 cells after subjected to 12 h hypoxia and followed 4 h reoxygenation.	tyrosyl-lysine	28-34	peroxiredoxin 3	Homo sapiens	13-18
31888761-2	2019	Disruptor of telomeric silencing-1-like (DOT1L), also known as KMT4, is the only identified histone methyltransferase that catalyzes the mono-, di-, and tri-methylation of lysine 79 histone 3 (H3K79).	tyrosyl-lysine	172-178	DOT1 like histone lysine methyltransferase	Homo sapiens	0-39
31888761-2	2019	Disruptor of telomeric silencing-1-like (DOT1L), also known as KMT4, is the only identified histone methyltransferase that catalyzes the mono-, di-, and tri-methylation of lysine 79 histone 3 (H3K79).	tyrosyl-lysine	172-178	DOT1 like histone lysine methyltransferase	Homo sapiens	41-46
31888761-2	2019	Disruptor of telomeric silencing-1-like (DOT1L), also known as KMT4, is the only identified histone methyltransferase that catalyzes the mono-, di-, and tri-methylation of lysine 79 histone 3 (H3K79).	tyrosyl-lysine	172-178	DOT1 like histone lysine methyltransferase	Homo sapiens	63-67
31676386-4	2019	Targeted ability was achieved through inserting different amino acids modified polyethylene glycol monostearate into the liposomes, and found that glutamate-liposomes can be targeted to LAT1, lysine-liposomes can be targeted to ATB0,+, and inspiringly, tyrosine-liposomes can be simultaneously targeted to LAT1 and ATB0,+.	tyrosyl-lysine	192-198	solute carrier family 1 member 5	Homo sapiens	228-232
31676386-4	2019	Targeted ability was achieved through inserting different amino acids modified polyethylene glycol monostearate into the liposomes, and found that glutamate-liposomes can be targeted to LAT1, lysine-liposomes can be targeted to ATB0,+, and inspiringly, tyrosine-liposomes can be simultaneously targeted to LAT1 and ATB0,+.	tyrosyl-lysine	192-198	solute carrier family 7 member 5	Homo sapiens	306-310
31676386-4	2019	Targeted ability was achieved through inserting different amino acids modified polyethylene glycol monostearate into the liposomes, and found that glutamate-liposomes can be targeted to LAT1, lysine-liposomes can be targeted to ATB0,+, and inspiringly, tyrosine-liposomes can be simultaneously targeted to LAT1 and ATB0,+.	tyrosyl-lysine	192-198	solute carrier family 1 member 5	Homo sapiens	315-319
31881804-9	2019	Furthermore, O-GlcNAcylation of NSL3 Thr755 site regulates the histone H4 acetylation levels at lysine 5, 8, and 16, suggesting that the O-GlcNAcylation of NSL3 at Thr755 is required for maintaining the integrity and holoenzyme activity of the MOF/NSL complex.	tyrosyl-lysine	96-102	KAT8 regulatory NSL complex subunit 3	Homo sapiens	32-36
31881804-9	2019	Furthermore, O-GlcNAcylation of NSL3 Thr755 site regulates the histone H4 acetylation levels at lysine 5, 8, and 16, suggesting that the O-GlcNAcylation of NSL3 at Thr755 is required for maintaining the integrity and holoenzyme activity of the MOF/NSL complex.	tyrosyl-lysine	96-102	KAT8 regulatory NSL complex subunit 3	Homo sapiens	156-160
31983877-5	2019	The transgenic plants that overexpressed SYNC1 gene had increased asparagine and lysine contents in matured seeds, and increased aspartate, lysine, alanine and histidine contents in germinated seeds.	tyrosyl-lysine	81-87	Class II aminoacyl-tRNA and biotin synthetases superfamily protein	Arabidopsis thaliana	41-46
31983877-5	2019	The transgenic plants that overexpressed SYNC1 gene had increased asparagine and lysine contents in matured seeds, and increased aspartate, lysine, alanine and histidine contents in germinated seeds.	tyrosyl-lysine	140-146	Class II aminoacyl-tRNA and biotin synthetases superfamily protein	Arabidopsis thaliana	41-46
31578284-1	2019	JARID2 is a non-catalytic member of the polycomb repressive complex 2 (PRC2) which methylates of histone 3 lysine 27 (H3K27).	tyrosyl-lysine	107-113	jumonji and AT-rich interaction domain containing 2	Homo sapiens	0-6
31861875-8	2019	The lysine-rich polybasic domain (PBD), a region that is unique for K-Ras4B as compared to H- and N-Ras, stabilizes the interaction and accounts for the specificity.	tyrosyl-lysine	4-10	KRAS proto-oncogene, GTPase	Homo sapiens	68-75
31861875-8	2019	The lysine-rich polybasic domain (PBD), a region that is unique for K-Ras4B as compared to H- and N-Ras, stabilizes the interaction and accounts for the specificity.	tyrosyl-lysine	4-10	NRAS proto-oncogene, GTPase	Homo sapiens	98-103
31862793-3	2019	Here, we show that lysine demethylase 5 (KDM5) is essential for prothoracic gland function.	tyrosyl-lysine	19-25	little imaginal discs	Drosophila melanogaster	41-45
31863007-0	2019	PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.	tyrosyl-lysine	20-26	polybromo 1	Homo sapiens	0-5
31863007-0	2019	PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.	tyrosyl-lysine	20-26	tumor protein p53	Homo sapiens	16-19
31863007-4	2019	Here, we identify PBRM1 as a reader for p53 acetylation on lysine 382 (K382Ac) through its bromodomain 4 (BD4).	tyrosyl-lysine	59-65	polybromo 1	Homo sapiens	18-23
31863007-4	2019	Here, we identify PBRM1 as a reader for p53 acetylation on lysine 382 (K382Ac) through its bromodomain 4 (BD4).	tyrosyl-lysine	59-65	tumor protein p53	Homo sapiens	40-43
31856871-15	2019	MYCN recruited PRC1 (Polycomb repressive complex 1), catalysed H2AK119ub (histone 2A lysine 119 monoubiquitination) and inhibited subsequent ELOVL2 transcription.	tyrosyl-lysine	85-91	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	0-4
31867407-9	2019	The experimental results lead us to propose a hypothesis that the DES increases the population of the conformer with distal ligand lysines close to the reaction center through the combining effect of urea and EAC, which results in the enhancement of the peroxidase activity of cytochrome c.	tyrosyl-lysine	131-138	cytochrome c, somatic	Homo sapiens	277-289
31848333-1	2019	PRDM9 is a PR domain containing protein which trimethylates histone 3 on lysine 4 and 36.	tyrosyl-lysine	73-79	PR/SET domain 9	Homo sapiens	0-5
31848340-5	2019	Instead, LATS1 stabilizes the autophagy core-machinery component Beclin-1 by promoting K27-linked ubiquitination at lysine residues K32 and K263 on Beclin-1.	tyrosyl-lysine	116-122	large tumor suppressor kinase 1	Homo sapiens	9-14
31848340-5	2019	Instead, LATS1 stabilizes the autophagy core-machinery component Beclin-1 by promoting K27-linked ubiquitination at lysine residues K32 and K263 on Beclin-1.	tyrosyl-lysine	116-122	beclin 1	Homo sapiens	65-73
31888209-1	2019	In breast cancer, Lysine-specific demethylase-1 (LSD1) and other lysine demethylases (KDMs), such as Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), are co-expressed and co-localize with estrogen receptors (ERs), suggesting the potential use of hybrid (epi)molecules to target histone methylation and therefore regulate/redirect hormone receptor signaling.	tyrosyl-lysine	65-71	lysine (K)-specific demethylase 1A	Mus musculus	49-53
31888209-1	2019	In breast cancer, Lysine-specific demethylase-1 (LSD1) and other lysine demethylases (KDMs), such as Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), are co-expressed and co-localize with estrogen receptors (ERs), suggesting the potential use of hybrid (epi)molecules to target histone methylation and therefore regulate/redirect hormone receptor signaling.	tyrosyl-lysine	65-71	lysine (K)-specific demethylase 6A	Mus musculus	101-131
31888209-1	2019	In breast cancer, Lysine-specific demethylase-1 (LSD1) and other lysine demethylases (KDMs), such as Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), are co-expressed and co-localize with estrogen receptors (ERs), suggesting the potential use of hybrid (epi)molecules to target histone methylation and therefore regulate/redirect hormone receptor signaling.	tyrosyl-lysine	65-71	lysine (K)-specific demethylase 6A	Mus musculus	211-214
31647098-0	2019	Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation.	tyrosyl-lysine	8-14	lysine demethylase 4B	Homo sapiens	27-32
31647098-0	2019	Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation.	tyrosyl-lysine	8-14	androgen receptor	Homo sapiens	75-92
31843902-3	2019	Here, we report that SIRT5, a mitochondrial NAD+-dependent lysine deacylase, plays a key role in stabilizing GLS.	tyrosyl-lysine	59-65	sirtuin 5	Homo sapiens	21-26
31871732-1	2019	Heterozygous pathogenic variants in the KAT6B gene, which encodes lysine acetyltransferase 6B, have been identified in patients with congenital rare disorders, including genitopatellar syndrome and Say-Barber-Biesecker-Young-Simpson syndrome.	tyrosyl-lysine	66-72	lysine acetyltransferase 6B	Homo sapiens	40-45
31718136-3	2019	G9a, also known as EHMT2 (euchromatic histone-lysine N-methyltransferase 2), is a histone methyltransferase predominantly responsible for dimethylation of histone H3 lysine 9 (H3K9).	tyrosyl-lysine	46-52	euchromatic histone lysine N-methyltransferase 2	Mus musculus	19-24
31701109-1	2019	As a member of the bromodomain and extra terminal domain (BET) protein family, bromodomain-containing protein 4 (BRD4) is an epigenetic reader and can recognize acetylated lysine residues in histones.	tyrosyl-lysine	172-178	bromodomain containing 4	Homo sapiens	79-111
31701109-1	2019	As a member of the bromodomain and extra terminal domain (BET) protein family, bromodomain-containing protein 4 (BRD4) is an epigenetic reader and can recognize acetylated lysine residues in histones.	tyrosyl-lysine	172-178	bromodomain containing 4	Homo sapiens	113-117
31817716-9	2019	This H2O2-induced loss of nucleus WHY1 isoform was accompanied by enhanced enrichments of histone H3 lysine 9 acetylation (H3K9ac) and recruitment of RNA polymerase II (RNAP II) globally, and specifically at the promoter of the senescence-related transcription factor WRKY53, which in turn activated WRKY53 transcription and led to a senescence phenotype.	tyrosyl-lysine	101-107	ssDNA-binding transcriptional regulator	Arabidopsis thaliana	34-38
31811253-3	2019	Pigs differed for a polymorphism at the aminoadipate-semialdehyde synthase (AASS) gene, involved in lysine (Lys) metabolism.	tyrosyl-lysine	100-106	aminoadipate-semialdehyde synthase	Sus scrofa	76-80
31811253-3	2019	Pigs differed for a polymorphism at the aminoadipate-semialdehyde synthase (AASS) gene, involved in lysine (Lys) metabolism.	tyrosyl-lysine	108-111	aminoadipate-semialdehyde synthase	Sus scrofa	76-80
31668005-5	2019	By global acetylomics, MS-275 promotes rapid acetylation of the YB-1 RNA-binding protein at lysine-81, blocking binding and translational activation of NFE2L2, as well as known YB-1 mRNA targets, HIF1A, and the stress granule nucleator, G3BP1.	tyrosyl-lysine	92-98	Y box protein 1	Mus musculus	64-68
31806006-9	2019	Four lysine residues (90, 289, 291 and 300) of TsENO were considered to be active residues for PLG interaction.	tyrosyl-lysine	5-11	plasminogen	Homo sapiens	95-98
31806006-12	2019	The four lysine residues (90, 289, 291 and 300) of TsENO play an important role in PLG binding and could accelerate PLG activation and invasion of the host"s intestinal wall by T. spiralis.	tyrosyl-lysine	9-15	plasminogen	Homo sapiens	83-86
31806006-12	2019	The four lysine residues (90, 289, 291 and 300) of TsENO play an important role in PLG binding and could accelerate PLG activation and invasion of the host"s intestinal wall by T. spiralis.	tyrosyl-lysine	9-15	plasminogen	Homo sapiens	116-119
31682411-7	2019	Using thioacylated lysine residues in p53-derived peptides we optimized substrates for HDAC8 with catalytic efficiency over 250,000 M-1s-1, which are more than 100-fold more effective than most of the known substrates.	tyrosyl-lysine	6-25	tumor protein p53	Homo sapiens	38-41
31682411-7	2019	Using thioacylated lysine residues in p53-derived peptides we optimized substrates for HDAC8 with catalytic efficiency over 250,000 M-1s-1, which are more than 100-fold more effective than most of the known substrates.	tyrosyl-lysine	6-25	histone deacetylase 8	Homo sapiens	87-92
31815204-2	2019	Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33.	tyrosyl-lysine	101-107	CD33 molecule	Homo sapiens	33-37
31815204-2	2019	Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33.	tyrosyl-lysine	101-107	CD33 molecule	Homo sapiens	39-44
31815204-2	2019	Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33.	tyrosyl-lysine	101-107	CD33 antigen	Mus musculus	40-44
31815204-2	2019	Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33.	tyrosyl-lysine	101-107	CD33 antigen	Mus musculus	63-68
31815204-2	2019	Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33.	tyrosyl-lysine	101-107	CD33 antigen	Mus musculus	111-116
31815204-5	2019	Notably, cell surface expression of mCD33 is entirely dependent on Dap12 due to an interaction with the transmembrane lysine in mCD33.	tyrosyl-lysine	118-124	CD33 antigen	Mus musculus	36-41
31815204-5	2019	Notably, cell surface expression of mCD33 is entirely dependent on Dap12 due to an interaction with the transmembrane lysine in mCD33.	tyrosyl-lysine	118-124	TYRO protein tyrosine kinase binding protein	Mus musculus	67-72
31815204-5	2019	Notably, cell surface expression of mCD33 is entirely dependent on Dap12 due to an interaction with the transmembrane lysine in mCD33.	tyrosyl-lysine	118-124	CD33 antigen	Mus musculus	128-133
31740576-11	2019	Inhibition of microRNA-137 in the CeA reverses increased alcohol intake and anxiety-like behavior, and this effect is mediated by lysine-specific demethylase 1 (LSD1), a microRNA-137 target gene that regulates epigenetic programming.	tyrosyl-lysine	130-136	microRNA 137	Rattus norvegicus	14-26
31740576-11	2019	Inhibition of microRNA-137 in the CeA reverses increased alcohol intake and anxiety-like behavior, and this effect is mediated by lysine-specific demethylase 1 (LSD1), a microRNA-137 target gene that regulates epigenetic programming.	tyrosyl-lysine	130-136	microRNA 137	Rattus norvegicus	170-182
31685529-5	2019	p62/SQSTM1 directed TRIM32 to lysosomal degradation, while TRIM32 mono-ubiquitylated p62/SQSTM1 on lysine residues involved in regulation of p62/SQSTM1 activity.	tyrosyl-lysine	99-105	tripartite motif containing 32	Homo sapiens	59-65
31685529-5	2019	p62/SQSTM1 directed TRIM32 to lysosomal degradation, while TRIM32 mono-ubiquitylated p62/SQSTM1 on lysine residues involved in regulation of p62/SQSTM1 activity.	tyrosyl-lysine	99-105	sequestosome 1	Homo sapiens	85-88
31685529-5	2019	p62/SQSTM1 directed TRIM32 to lysosomal degradation, while TRIM32 mono-ubiquitylated p62/SQSTM1 on lysine residues involved in regulation of p62/SQSTM1 activity.	tyrosyl-lysine	99-105	sequestosome 1	Homo sapiens	89-95
31685529-5	2019	p62/SQSTM1 directed TRIM32 to lysosomal degradation, while TRIM32 mono-ubiquitylated p62/SQSTM1 on lysine residues involved in regulation of p62/SQSTM1 activity.	tyrosyl-lysine	99-105	sequestosome 1	Homo sapiens	85-88
31685529-5	2019	p62/SQSTM1 directed TRIM32 to lysosomal degradation, while TRIM32 mono-ubiquitylated p62/SQSTM1 on lysine residues involved in regulation of p62/SQSTM1 activity.	tyrosyl-lysine	99-105	sequestosome 1	Homo sapiens	89-95
31724824-1	2019	The EZH2, EED, and SUZ12 genes encode proteins that comprise core components of the polycomb repressive complex 2 (PRC2), an epigenetic "writer" with H3K27 methyltransferase activity, catalyzing the addition of up to three methyl groups on histone 3 at lysine residue 27 (H3K27).	tyrosyl-lysine	253-259	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	4-8
31724824-1	2019	The EZH2, EED, and SUZ12 genes encode proteins that comprise core components of the polycomb repressive complex 2 (PRC2), an epigenetic "writer" with H3K27 methyltransferase activity, catalyzing the addition of up to three methyl groups on histone 3 at lysine residue 27 (H3K27).	tyrosyl-lysine	253-259	embryonic ectoderm development	Homo sapiens	10-13
31724824-1	2019	The EZH2, EED, and SUZ12 genes encode proteins that comprise core components of the polycomb repressive complex 2 (PRC2), an epigenetic "writer" with H3K27 methyltransferase activity, catalyzing the addition of up to three methyl groups on histone 3 at lysine residue 27 (H3K27).	tyrosyl-lysine	253-259	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	19-24
31805626-3	2019	In order to tackle this issue, we conducted functional analysis of the histone lysine-specific demethylase (LSD1) to explore the possibility that this enzyme acts as a therapeutic target in HCC.	tyrosyl-lysine	79-85	lysine demethylase 1A	Homo sapiens	108-112
31633391-6	2019	In human cells, IFN-I treatment induces K63-linked ubiquitination on lysine (K) 6 of YFV NS5, which is required for binding human STAT2.	tyrosyl-lysine	69-75	interferon alpha 1	Homo sapiens	16-19
31633391-6	2019	In human cells, IFN-I treatment induces K63-linked ubiquitination on lysine (K) 6 of YFV NS5, which is required for binding human STAT2.	tyrosyl-lysine	69-75	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	89-92
31633391-6	2019	In human cells, IFN-I treatment induces K63-linked ubiquitination on lysine (K) 6 of YFV NS5, which is required for binding human STAT2.	tyrosyl-lysine	69-75	signal transducer and activator of transcription 2	Homo sapiens	130-135
31608710-10	2019	In addition, up-regulation of EZH2 promoted trimethylation of lysine 27 on histone H3, therefore suppressing ABCA1 expression, eventually leading to the inhibition of RGC apoptosis.	tyrosyl-lysine	62-68	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	30-34
31894128-4	2019	We report that AurkB undergoes acetylation in vitro by lysine acetyltransferases (KATs) belonging to different families, namely by p300 and Tip60.	tyrosyl-lysine	55-61	aurora kinase B	Homo sapiens	15-20
31894128-4	2019	We report that AurkB undergoes acetylation in vitro by lysine acetyltransferases (KATs) belonging to different families, namely by p300 and Tip60.	tyrosyl-lysine	55-61	lysine acetyltransferase 5	Homo sapiens	140-145
31894128-5	2019	The haploinsufficient tumor suppressor Tip60 acetylates two highly conserved lysine residues within the kinase domain of AurkB which not only impinges the protein stability but also its kinase activity.	tyrosyl-lysine	77-83	lysine acetyltransferase 5	Homo sapiens	39-44
31894128-5	2019	The haploinsufficient tumor suppressor Tip60 acetylates two highly conserved lysine residues within the kinase domain of AurkB which not only impinges the protein stability but also its kinase activity.	tyrosyl-lysine	77-83	aurora kinase B	Homo sapiens	121-126
31611261-7	2019	Mechanistically, hresistin promoted HMGB1 posttranslational lysine acetylation by preserving the NAD+-dependent deacetylase sirtuin (Sirt) 1 in human macrophages.	tyrosyl-lysine	60-66	resistin	Homo sapiens	17-26
31611261-7	2019	Mechanistically, hresistin promoted HMGB1 posttranslational lysine acetylation by preserving the NAD+-dependent deacetylase sirtuin (Sirt) 1 in human macrophages.	tyrosyl-lysine	60-66	high mobility group box 1	Homo sapiens	36-41
31619538-5	2019	Src undergoes polyinosinic:polycytidylic acid-dependent lysine 63 chain ubiquitination, and TRAF2 is a direct E3 ligase for Src.	tyrosyl-lysine	56-62	Rous sarcoma oncogene	Mus musculus	0-3
31807181-1	2019	Translocation (9;11)(p21.3;q23.3) is one of the most common lysine methyltransferase 2A (KMT2A)-rearrangements in de novo and therapy-related acute myeloid leukemia (AML).	tyrosyl-lysine	60-66	lysine methyltransferase 2A	Homo sapiens	89-94
31653699-9	2019	Furthermore, we found that two lysine sites on residues 268 and 293 in PPARgamma are targeted for CRL4B-mediated ubiquitination, indicating cross-talk between acetylation and ubiquitination.	tyrosyl-lysine	31-37	peroxisome proliferator activated receptor gamma	Mus musculus	71-80
31784689-2	2019	Histone acetyltransferase 1 (Hat1) proteins are conserved enzymes that modify histones by acetylating lysine residues.	tyrosyl-lysine	102-108	chameau	Drosophila melanogaster	0-27
31784689-2	2019	Histone acetyltransferase 1 (Hat1) proteins are conserved enzymes that modify histones by acetylating lysine residues.	tyrosyl-lysine	102-108	chameau	Drosophila melanogaster	29-33
31784689-6	2019	Lack of Hat1 results in the near complete loss of histone H4 lysine (K) 5 and K12 acetylation in embryos, indicating that Hat1 is the main acetyltransferase specific for these marks in this developmental stage.	tyrosyl-lysine	61-67	chameau	Drosophila melanogaster	8-12
31784689-6	2019	Lack of Hat1 results in the near complete loss of histone H4 lysine (K) 5 and K12 acetylation in embryos, indicating that Hat1 is the main acetyltransferase specific for these marks in this developmental stage.	tyrosyl-lysine	61-67	chameau	Drosophila melanogaster	122-126
31720639-3	2019	In this study, we performed atomistic molecular dynamics (MD) simulations of lysine 116 PEGylated bovine serum albumin (BSA) to illustrate how conjugation near a hydrophobic pocket affects the conjugate"s dynamics and observed altered low mode vibrations in the protein.	tyrosyl-lysine	77-83	albumin	Homo sapiens	105-118
31776402-2	2019	Histone lysine demethylase KDM5B (PLU-1) catalyzes the demethylation of histone H3 on Lys 4 (H3K4), which results in the repression of gene expression.	tyrosyl-lysine	8-14	lysine demethylase 5B	Homo sapiens	27-32
31776402-2	2019	Histone lysine demethylase KDM5B (PLU-1) catalyzes the demethylation of histone H3 on Lys 4 (H3K4), which results in the repression of gene expression.	tyrosyl-lysine	8-14	lysine demethylase 5B	Homo sapiens	34-39
31765372-2	2019	Here we report that the Pol epsilon catalytic subunit Pol2 in yeast is sumoylated at a single lysine within a catalytic domain insertion uniquely possessed by Pol2 family members.	tyrosyl-lysine	94-100	DNA polymerase epsilon catalytic subunit	Saccharomyces cerevisiae S288C	54-58
31765372-2	2019	Here we report that the Pol epsilon catalytic subunit Pol2 in yeast is sumoylated at a single lysine within a catalytic domain insertion uniquely possessed by Pol2 family members.	tyrosyl-lysine	94-100	DNA polymerase epsilon catalytic subunit	Saccharomyces cerevisiae S288C	159-163
31727574-3	2019	Here, we show that p300 acetylates H2A.Z at multiple lysines.	tyrosyl-lysine	53-60	E1A binding protein p300	Homo sapiens	19-23
31727574-3	2019	Here, we show that p300 acetylates H2A.Z at multiple lysines.	tyrosyl-lysine	53-60	H2A.Z variant histone 1	Homo sapiens	35-40
31580078-2	2019	Here we present specific 13CHD2 labeling of dimethylated lysines as a sensitive probe of structure, interactions, and dynamics of these groups, and outline a theoretical and experimental framework for analyzing their conformational dynamics using 1H and 13C CPMG relaxation dispersion experiments.	tyrosyl-lysine	44-64	chromodomain helicase DNA binding protein 2	Homo sapiens	27-31
31580078-3	2019	Dimethylated lysine side chains in calcium-loaded calmodulin show a marked pH dependence of their CPMG dispersion profiles, indicating complex exchange behavior.	tyrosyl-lysine	13-19	calmodulin 1	Homo sapiens	50-60
31756917-3	2019	Lysine specific demethylase 1 (LSD1/KDM1A) plays a well-established role in the normal hematopoietic and neuronal stem cells.	tyrosyl-lysine	0-6	lysine demethylase 1A	Homo sapiens	31-35
31756917-3	2019	Lysine specific demethylase 1 (LSD1/KDM1A) plays a well-established role in the normal hematopoietic and neuronal stem cells.	tyrosyl-lysine	0-6	lysine demethylase 1A	Homo sapiens	36-41
31591207-0	2019	SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer.	tyrosyl-lysine	20-26	superoxide dismutase 2	Homo sapiens	0-4
31591207-3	2019	Our results indicate that as SOD2 expression increases acetylation of lysine 68 ensues.	tyrosyl-lysine	70-76	superoxide dismutase 2	Homo sapiens	29-33
31788622-1	2019	Histone deacetylase 11 (HDAC11) preferentially removes fatty acid residues from lysine side chains in a peptide or protein environment.	tyrosyl-lysine	80-86	histone deacetylase 11	Homo sapiens	0-22
31788622-1	2019	Histone deacetylase 11 (HDAC11) preferentially removes fatty acid residues from lysine side chains in a peptide or protein environment.	tyrosyl-lysine	80-86	histone deacetylase 11	Homo sapiens	24-30
31652307-0	2019	Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1.	tyrosyl-lysine	48-54	kelch like family member 5	Homo sapiens	0-20
31652307-0	2019	Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1.	tyrosyl-lysine	48-54	sphingosine kinase 1	Homo sapiens	95-115
31586032-5	2019	Ectopic PU.1 expression induced remodeling of a novel distal enhancer (located ~10 kbp upstream of the IL-1beta transcription start site), marked by nucleosome-depletion, enhancer-promoter looping and histone H3 lysine 27 acetylation (H3K27ac).	tyrosyl-lysine	212-218	spleen focus forming virus (SFFV) proviral integration oncogene	Mus musculus	8-12
31591264-8	2019	Mechanistic analyses at the endogenous ERVW1, CGA and CGB loci revealed a regulatory axis in which LSD1 induces demethylation of repressive histone H3 lysine 9 dimethylation (H3K9Me2) and interacts with transcription factor GATA2 to promote RNA polymerase II (RNA-POL-II) recruitment and activate gene transcription.	tyrosyl-lysine	151-157	lysine demethylase 1A	Homo sapiens	99-103
31727944-2	2019	Rearrangements of MLL protein (MLL-r) in complexes that contain the histone methyltransferase DOT1L are common, which elicit abnormal methylation of lysine 79 of histone H3 at MLL target genes.	tyrosyl-lysine	149-155	lysine methyltransferase 2A	Homo sapiens	18-21
31727944-2	2019	Rearrangements of MLL protein (MLL-r) in complexes that contain the histone methyltransferase DOT1L are common, which elicit abnormal methylation of lysine 79 of histone H3 at MLL target genes.	tyrosyl-lysine	149-155	lysine methyltransferase 2A	Homo sapiens	31-34
31727944-2	2019	Rearrangements of MLL protein (MLL-r) in complexes that contain the histone methyltransferase DOT1L are common, which elicit abnormal methylation of lysine 79 of histone H3 at MLL target genes.	tyrosyl-lysine	149-155	DOT1 like histone lysine methyltransferase	Homo sapiens	94-99
31727944-2	2019	Rearrangements of MLL protein (MLL-r) in complexes that contain the histone methyltransferase DOT1L are common, which elicit abnormal methylation of lysine 79 of histone H3 at MLL target genes.	tyrosyl-lysine	149-155	lysine methyltransferase 2A	Homo sapiens	31-34
31728037-8	2019	By systematically mutagenizing the residues of the LAT1 cytosolic tails, we identified a group of three close lysines (K19, K25, K30) in the N-terminal tail that are important for PMA-induced ubiquitylation and downregulation.	tyrosyl-lysine	110-117	solute carrier family 7 member 5	Homo sapiens	51-55
31921558-6	2020	Mechanistically, IL1R2 is activated by IL1beta, as demonstrated by the fact that IL1beta induces the release of IL1R2 intracellular domain (icd-IL1R2) and icd-IL1R2 then interacts with the deubiquitinase USP15 at the UBL2 domain and promotes its activity, which finally induces BMI1 deubiquitination at lysine 81 and stabilizes BMI1 protein.	tyrosyl-lysine	303-309	interleukin 1 receptor type 2	Homo sapiens	17-22
31921558-6	2020	Mechanistically, IL1R2 is activated by IL1beta, as demonstrated by the fact that IL1beta induces the release of IL1R2 intracellular domain (icd-IL1R2) and icd-IL1R2 then interacts with the deubiquitinase USP15 at the UBL2 domain and promotes its activity, which finally induces BMI1 deubiquitination at lysine 81 and stabilizes BMI1 protein.	tyrosyl-lysine	303-309	interleukin 1 beta	Homo sapiens	39-46
31921558-6	2020	Mechanistically, IL1R2 is activated by IL1beta, as demonstrated by the fact that IL1beta induces the release of IL1R2 intracellular domain (icd-IL1R2) and icd-IL1R2 then interacts with the deubiquitinase USP15 at the UBL2 domain and promotes its activity, which finally induces BMI1 deubiquitination at lysine 81 and stabilizes BMI1 protein.	tyrosyl-lysine	303-309	interleukin 1 beta	Homo sapiens	81-88
31921558-6	2020	Mechanistically, IL1R2 is activated by IL1beta, as demonstrated by the fact that IL1beta induces the release of IL1R2 intracellular domain (icd-IL1R2) and icd-IL1R2 then interacts with the deubiquitinase USP15 at the UBL2 domain and promotes its activity, which finally induces BMI1 deubiquitination at lysine 81 and stabilizes BMI1 protein.	tyrosyl-lysine	303-309	interleukin 1 receptor type 2	Homo sapiens	112-117
31921558-6	2020	Mechanistically, IL1R2 is activated by IL1beta, as demonstrated by the fact that IL1beta induces the release of IL1R2 intracellular domain (icd-IL1R2) and icd-IL1R2 then interacts with the deubiquitinase USP15 at the UBL2 domain and promotes its activity, which finally induces BMI1 deubiquitination at lysine 81 and stabilizes BMI1 protein.	tyrosyl-lysine	303-309	interleukin 1 receptor type 2	Homo sapiens	112-117
31921558-6	2020	Mechanistically, IL1R2 is activated by IL1beta, as demonstrated by the fact that IL1beta induces the release of IL1R2 intracellular domain (icd-IL1R2) and icd-IL1R2 then interacts with the deubiquitinase USP15 at the UBL2 domain and promotes its activity, which finally induces BMI1 deubiquitination at lysine 81 and stabilizes BMI1 protein.	tyrosyl-lysine	303-309	interleukin 1 receptor type 2	Homo sapiens	112-117
31766290-1	2019	Our three-dimensional organotypic culture revealed that human histone demethylase (KDM) 4C, a histone lysine demethylase, hindered the acini morphogenesis of RWPE-1 prostate cells, suggesting its potential oncogenic role.	tyrosyl-lysine	102-108	lysine demethylase 4C	Homo sapiens	62-90
31788423-1	2019	Biallelic mutations of the GCDH gene result in Glutaric Aciduria type 1 (GA1; OMIM #231670), an uncommon autosomal recessive inborn error caused by the deficiency of glutaryl-CoA dehydrogenase (CCDH), a mitochondrial matrix protein involved in the degradation of l-lysine, L-hydroxylysine, and L-tryptophan.	tyrosyl-lysine	263-271	glutaryl-CoA dehydrogenase	Homo sapiens	27-31
31788587-0	2019	Exploration of the Substrate Preference of Lysine Methyltransferase SMYD3 by Molecular Dynamics Simulations.	tyrosyl-lysine	43-49	SET and MYND domain containing 3	Homo sapiens	68-73
31788587-1	2019	SMYD3, a SET and MYND domain containing lysine methyltransferase, catalyzes the transfer of the methyl group from a methyl donor onto the Nepsilon group of a lysine residue in the substrate protein.	tyrosyl-lysine	40-46	SET and MYND domain containing 3	Homo sapiens	0-5
31788587-1	2019	SMYD3, a SET and MYND domain containing lysine methyltransferase, catalyzes the transfer of the methyl group from a methyl donor onto the Nepsilon group of a lysine residue in the substrate protein.	tyrosyl-lysine	158-164	SET and MYND domain containing 3	Homo sapiens	0-5
31780938-2	2019	The bromodomain and extraterminal (BET) protein family (BRD2, BRD3, BRD4, and BRDT) are epigenetic readers that, via bromodomains, regulate gene transcription by binding to acetylated lysine residues on histones and master transcriptional factors.	tyrosyl-lysine	184-190	delta/notch like EGF repeat containing	Homo sapiens	35-38
31780938-2	2019	The bromodomain and extraterminal (BET) protein family (BRD2, BRD3, BRD4, and BRDT) are epigenetic readers that, via bromodomains, regulate gene transcription by binding to acetylated lysine residues on histones and master transcriptional factors.	tyrosyl-lysine	184-190	bromodomain containing 2	Homo sapiens	56-60
31780938-2	2019	The bromodomain and extraterminal (BET) protein family (BRD2, BRD3, BRD4, and BRDT) are epigenetic readers that, via bromodomains, regulate gene transcription by binding to acetylated lysine residues on histones and master transcriptional factors.	tyrosyl-lysine	184-190	bromodomain containing 3	Homo sapiens	62-66
31780938-2	2019	The bromodomain and extraterminal (BET) protein family (BRD2, BRD3, BRD4, and BRDT) are epigenetic readers that, via bromodomains, regulate gene transcription by binding to acetylated lysine residues on histones and master transcriptional factors.	tyrosyl-lysine	184-190	bromodomain containing 4	Homo sapiens	68-72
31780938-2	2019	The bromodomain and extraterminal (BET) protein family (BRD2, BRD3, BRD4, and BRDT) are epigenetic readers that, via bromodomains, regulate gene transcription by binding to acetylated lysine residues on histones and master transcriptional factors.	tyrosyl-lysine	184-190	bromodomain testis associated	Homo sapiens	78-82
31613097-5	2019	Here, we have envisaged that the inherent conformational dynamics of CaM is primarily triggered by a dual salt bridge interaction between the glutamates and lysine at two different domains (N and C terminal domains) of the protein.	tyrosyl-lysine	157-163	calmodulin 1	Homo sapiens	69-72
31780941-12	2019	The abnormal lysine degradation metabolism, valine-leucine-isoleucine biosynthesis, and citrate circle were considered to weigh the most in the development of PSS.	tyrosyl-lysine	13-19	PSS	Homo sapiens	159-162
31699991-0	2019	Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia.	tyrosyl-lysine	8-14	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	33-37
31699991-0	2019	Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia.	tyrosyl-lysine	8-14	RUNX family transcription factor 1	Homo sapiens	47-51
31699991-0	2019	Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia.	tyrosyl-lysine	8-14	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	52-55
31699991-3	2019	Here we report that AML1-ETO-positive patients, with high histone lysine methyltransferase Enhancer of zeste homolog 1 (EZH1) expression, show a worse overall survival than those with lower EZH1 expression.	tyrosyl-lysine	66-72	RUNX family transcription factor 1	Homo sapiens	20-24
31699991-3	2019	Here we report that AML1-ETO-positive patients, with high histone lysine methyltransferase Enhancer of zeste homolog 1 (EZH1) expression, show a worse overall survival than those with lower EZH1 expression.	tyrosyl-lysine	66-72	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	25-28
31699991-3	2019	Here we report that AML1-ETO-positive patients, with high histone lysine methyltransferase Enhancer of zeste homolog 1 (EZH1) expression, show a worse overall survival than those with lower EZH1 expression.	tyrosyl-lysine	66-72	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	120-124
31699991-5	2019	We find that EZH1 WD domain binds to the AML1-ETO NHR1 domain and methylates AML1-ETO at lysine 43 (Lys43).	tyrosyl-lysine	89-95	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	13-17
31699991-5	2019	We find that EZH1 WD domain binds to the AML1-ETO NHR1 domain and methylates AML1-ETO at lysine 43 (Lys43).	tyrosyl-lysine	89-95	RUNX family transcription factor 1	Homo sapiens	77-81
31699991-5	2019	We find that EZH1 WD domain binds to the AML1-ETO NHR1 domain and methylates AML1-ETO at lysine 43 (Lys43).	tyrosyl-lysine	89-95	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	82-85
31699991-8	2019	These findings highlight the role of EZH1 in non-histone lysine methylation, indicating that cooperation between AML1-ETO and EZH1 and AML1-ETO site-specific lysine methylation promote AML1-ETO transcriptional repression in leukemia.	tyrosyl-lysine	57-63	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	37-41
31699991-8	2019	These findings highlight the role of EZH1 in non-histone lysine methylation, indicating that cooperation between AML1-ETO and EZH1 and AML1-ETO site-specific lysine methylation promote AML1-ETO transcriptional repression in leukemia.	tyrosyl-lysine	57-63	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	118-121
31699991-8	2019	These findings highlight the role of EZH1 in non-histone lysine methylation, indicating that cooperation between AML1-ETO and EZH1 and AML1-ETO site-specific lysine methylation promote AML1-ETO transcriptional repression in leukemia.	tyrosyl-lysine	158-164	RUNX family transcription factor 1	Homo sapiens	135-139
31699991-8	2019	These findings highlight the role of EZH1 in non-histone lysine methylation, indicating that cooperation between AML1-ETO and EZH1 and AML1-ETO site-specific lysine methylation promote AML1-ETO transcriptional repression in leukemia.	tyrosyl-lysine	158-164	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	140-143
31699991-8	2019	These findings highlight the role of EZH1 in non-histone lysine methylation, indicating that cooperation between AML1-ETO and EZH1 and AML1-ETO site-specific lysine methylation promote AML1-ETO transcriptional repression in leukemia.	tyrosyl-lysine	158-164	RUNX family transcription factor 1	Homo sapiens	135-139
31699991-8	2019	These findings highlight the role of EZH1 in non-histone lysine methylation, indicating that cooperation between AML1-ETO and EZH1 and AML1-ETO site-specific lysine methylation promote AML1-ETO transcriptional repression in leukemia.	tyrosyl-lysine	158-164	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	140-143
31606247-1	2019	SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene.	tyrosyl-lysine	10-16	SET domain containing 1A	Mus musculus	0-6
31540973-3	2019	Ash1 is the Trithorax protein that was proposed to counteract Polycomb repression by methylating lysine 36 of histone H3.	tyrosyl-lysine	97-103	absent, small, or homeotic discs 1	Drosophila melanogaster	0-4
31540973-3	2019	Ash1 is the Trithorax protein that was proposed to counteract Polycomb repression by methylating lysine 36 of histone H3.	tyrosyl-lysine	97-103	trithorax	Drosophila melanogaster	12-21
31540973-3	2019	Ash1 is the Trithorax protein that was proposed to counteract Polycomb repression by methylating lysine 36 of histone H3.	tyrosyl-lysine	97-103	Polycomb	Drosophila melanogaster	62-70
31544921-1	2019	The Mixed Lineage Leukemia protein 1 (MLL1) plays an essential role in the maintenance of the histone H3 lysine 4 (H3K4) methylation status for gene expression during differentiation and development.	tyrosyl-lysine	105-113	lysine methyltransferase 2A	Homo sapiens	4-36
31544921-1	2019	The Mixed Lineage Leukemia protein 1 (MLL1) plays an essential role in the maintenance of the histone H3 lysine 4 (H3K4) methylation status for gene expression during differentiation and development.	tyrosyl-lysine	105-113	lysine methyltransferase 2A	Homo sapiens	38-42
31867164-7	2019	Thus, SIRT2 was used to modify substrates by truncating the amino acids or lysine side chain of nonapeptide.	tyrosyl-lysine	75-81	sirtuin 2	Homo sapiens	6-11
31737645-2	2019	Analysis of SMYD3 interactome indicates this protein lysine methyltransferase might be involved in calcium dependent signaling pathways through forming complexes with the phospholipase PLCB3, calcium/calmodulin dependent kinase CAMK2B, or calcineurin inhibitor RCAN3.	tyrosyl-lysine	53-59	SET and MYND domain containing 3	Homo sapiens	12-17
31737645-2	2019	Analysis of SMYD3 interactome indicates this protein lysine methyltransferase might be involved in calcium dependent signaling pathways through forming complexes with the phospholipase PLCB3, calcium/calmodulin dependent kinase CAMK2B, or calcineurin inhibitor RCAN3.	tyrosyl-lysine	53-59	phospholipase C beta 3	Homo sapiens	185-190
31737645-2	2019	Analysis of SMYD3 interactome indicates this protein lysine methyltransferase might be involved in calcium dependent signaling pathways through forming complexes with the phospholipase PLCB3, calcium/calmodulin dependent kinase CAMK2B, or calcineurin inhibitor RCAN3.	tyrosyl-lysine	53-59	calcium/calmodulin dependent protein kinase II beta	Homo sapiens	228-234
31737645-2	2019	Analysis of SMYD3 interactome indicates this protein lysine methyltransferase might be involved in calcium dependent signaling pathways through forming complexes with the phospholipase PLCB3, calcium/calmodulin dependent kinase CAMK2B, or calcineurin inhibitor RCAN3.	tyrosyl-lysine	53-59	RCAN family member 3	Homo sapiens	261-266
31570196-3	2019	Recently, the accumulation of p16INK4a-positive cells in the kidney has been considered a molecular feature of renal senescence, with the p16INK4a gene reportedly regulated by mixed-lineage leukemia 1 (MLL1)/WD-40 repeat protein 5 (WDR5)-mediated histone 3 lysine 4 trimethylation (H3K4me3).	tyrosyl-lysine	257-263	cyclin dependent kinase inhibitor 2A	Mus musculus	138-146
31570196-3	2019	Recently, the accumulation of p16INK4a-positive cells in the kidney has been considered a molecular feature of renal senescence, with the p16INK4a gene reportedly regulated by mixed-lineage leukemia 1 (MLL1)/WD-40 repeat protein 5 (WDR5)-mediated histone 3 lysine 4 trimethylation (H3K4me3).	tyrosyl-lysine	257-263	lysine (K)-specific methyltransferase 2A	Mus musculus	176-200
31570196-3	2019	Recently, the accumulation of p16INK4a-positive cells in the kidney has been considered a molecular feature of renal senescence, with the p16INK4a gene reportedly regulated by mixed-lineage leukemia 1 (MLL1)/WD-40 repeat protein 5 (WDR5)-mediated histone 3 lysine 4 trimethylation (H3K4me3).	tyrosyl-lysine	257-263	lysine (K)-specific methyltransferase 2A	Mus musculus	202-206
31576004-3	2019	Here we demonstrate that the acetyltransferase GCN5 contributes to ATRA resistance in non-APL AML via aberrant acetylation of histone 3 lysine 9 (H3K9ac) residues maintaining the expression of stemness and leukemia associated genes.	tyrosyl-lysine	136-142	lysine acetyltransferase 2A	Homo sapiens	47-51
31576004-5	2019	This response is potentiated by coinhibition of the lysine demethylase LSD1, leading to differentiation in most non-APL AML.	tyrosyl-lysine	52-58	lysine demethylase 1A	Homo sapiens	71-75
31685992-3	2019	Here, we demonstrate that, in contrast with the well-established tumour-suppressive role of canonical PTEN, PTENalpha and PTENbeta promote tumourigenesis by directly interacting with the histone H3 lysine 4 (H3K4) presenter WDR5 to promote H3K4 trimethylation and maintain a tumour-promoting signature.	tyrosyl-lysine	198-206	WD repeat domain 5	Homo sapiens	224-228
31673058-4	2019	Heparin-induced p17 oligomerization is of electrostatic nature, being it prevented by NaCl, by removing negative sulfated groups of heparin and by neutralizing positive lysine residues in the p17 N-terminus.	tyrosyl-lysine	169-175	family with sequence similarity 72 member B	Homo sapiens	16-19
31673058-4	2019	Heparin-induced p17 oligomerization is of electrostatic nature, being it prevented by NaCl, by removing negative sulfated groups of heparin and by neutralizing positive lysine residues in the p17 N-terminus.	tyrosyl-lysine	169-175	family with sequence similarity 72 member B	Homo sapiens	192-195
31640975-8	2019	Moreover, PIASy overexpression leads to increased trimethylation of histone H3 lysine 9 (H3K9me3) in two-cell nuclei and enhanced translocation of H3K9me3 methyltransferase to the pronucleus.	tyrosyl-lysine	79-85	protein inhibitor of activated STAT 4	Homo sapiens	10-15
31550155-0	2019	Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy.	tyrosyl-lysine	25-31	islet amyloid polypeptide	Homo sapiens	41-76
31550155-0	2019	Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy.	tyrosyl-lysine	25-31	islet amyloid polypeptide	Homo sapiens	78-81
31586028-3	2019	4 lysine residues (K38KKK) located in the N-terminal domain of caspase-7 form such an exosite and promote the rapid proteolysis of the poly(ADP-ribose) polymerase 1 (PARP-1), but the mechanism of recognition remains mostly unknown.	tyrosyl-lysine	2-8	caspase 7	Homo sapiens	63-72
31586028-3	2019	4 lysine residues (K38KKK) located in the N-terminal domain of caspase-7 form such an exosite and promote the rapid proteolysis of the poly(ADP-ribose) polymerase 1 (PARP-1), but the mechanism of recognition remains mostly unknown.	tyrosyl-lysine	2-8	poly(ADP-ribose) polymerase 1	Homo sapiens	135-164
31586028-3	2019	4 lysine residues (K38KKK) located in the N-terminal domain of caspase-7 form such an exosite and promote the rapid proteolysis of the poly(ADP-ribose) polymerase 1 (PARP-1), but the mechanism of recognition remains mostly unknown.	tyrosyl-lysine	2-8	poly(ADP-ribose) polymerase 1	Homo sapiens	166-172
31617627-6	2019	Interestingly, compound 4h inactivated histone lysine specific demethylase 1 (LSD1) potently with an IC50 value of 0.296 muM.	tyrosyl-lysine	47-53	lysine demethylase 1A	Homo sapiens	78-82
31540912-3	2019	Mutations that disrupt histone H3 lysine 9 (H3K9) methyltransferases reveal that the methyltransferase MET-2 helps terminate developmental plasticity, through mono- and di-methylation of H3K9 (me1/me2), and promotes heterochromatin formation, through H3K9me3.	tyrosyl-lysine	34-40	Histone-lysine N-methyltransferase met-2	Caenorhabditis elegans	103-108
31649884-2	2019	Recent studies have shown that small molecules targeting Lysine Specific Demethylase 1A (KDM1A) may force the malignant cells to terminally differentiate.	tyrosyl-lysine	57-63	lysine demethylase 1A	Homo sapiens	89-94
31594538-4	2019	RESULTS: Here, we present data suggesting that LSH regulates p53 in cis through two pathways: prevention proteasomal degradation through its deubiquitination, which is achieved by reducing the lysine 11-linked, lysine 48-linked polyubiquitin chains (K11 and K48) on p53; and revival of the transcriptional activity of p53 by forming a complex with PKM2 (pyruvate kinase 2).	tyrosyl-lysine	193-199	helicase, lymphoid specific	Homo sapiens	47-50
31594538-4	2019	RESULTS: Here, we present data suggesting that LSH regulates p53 in cis through two pathways: prevention proteasomal degradation through its deubiquitination, which is achieved by reducing the lysine 11-linked, lysine 48-linked polyubiquitin chains (K11 and K48) on p53; and revival of the transcriptional activity of p53 by forming a complex with PKM2 (pyruvate kinase 2).	tyrosyl-lysine	193-199	tumor protein p53	Homo sapiens	61-64
31594538-4	2019	RESULTS: Here, we present data suggesting that LSH regulates p53 in cis through two pathways: prevention proteasomal degradation through its deubiquitination, which is achieved by reducing the lysine 11-linked, lysine 48-linked polyubiquitin chains (K11 and K48) on p53; and revival of the transcriptional activity of p53 by forming a complex with PKM2 (pyruvate kinase 2).	tyrosyl-lysine	211-217	helicase, lymphoid specific	Homo sapiens	47-50
31594538-4	2019	RESULTS: Here, we present data suggesting that LSH regulates p53 in cis through two pathways: prevention proteasomal degradation through its deubiquitination, which is achieved by reducing the lysine 11-linked, lysine 48-linked polyubiquitin chains (K11 and K48) on p53; and revival of the transcriptional activity of p53 by forming a complex with PKM2 (pyruvate kinase 2).	tyrosyl-lysine	211-217	tumor protein p53	Homo sapiens	61-64
31645904-2	2019	The SAGA complex is recruited to chromatin by transcription factors such as MYC and E2F1 to facilitate acetylation of histones, especially H3 at lysine 9 (H3K9).	tyrosyl-lysine	145-151	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	76-79
31645904-2	2019	The SAGA complex is recruited to chromatin by transcription factors such as MYC and E2F1 to facilitate acetylation of histones, especially H3 at lysine 9 (H3K9).	tyrosyl-lysine	145-151	E2F transcription factor 1	Homo sapiens	84-88
31720078-1	2019	Enhancer of zeste homolog 2 (EZH2) mediates epigenetic gene silencing via tri-methylation of histone H3 lysine 27 (H3K27-me3).	tyrosyl-lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
31720078-1	2019	Enhancer of zeste homolog 2 (EZH2) mediates epigenetic gene silencing via tri-methylation of histone H3 lysine 27 (H3K27-me3).	tyrosyl-lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
31577950-5	2019	Upon DNA damage, the induction of the de-NEDDylating enzyme NEDP1 restricts the formation of NEDD8 chains, mainly through lysines K11/K48.	tyrosyl-lysine	122-129	SUMO peptidase family member, NEDD8 specific	Homo sapiens	60-65
31577950-5	2019	Upon DNA damage, the induction of the de-NEDDylating enzyme NEDP1 restricts the formation of NEDD8 chains, mainly through lysines K11/K48.	tyrosyl-lysine	122-129	NEDD8 ubiquitin like modifier	Homo sapiens	93-98
31720371-2	2019	While hyper-methylation of histone H3 catalyzed by disruptor of telomeric silencing 1-like (DOT1L), a specific methyltransferase for histone H3 at lysine residue 79 (H3K79), is reported as a potential target for TNBCs, early developed nucleoside-type DOT1L inhibitors are not sufficient for effective inhibition of growth and metastasis of TNBC cells.	tyrosyl-lysine	147-153	DOT1 like histone lysine methyltransferase	Homo sapiens	92-97
31720371-2	2019	While hyper-methylation of histone H3 catalyzed by disruptor of telomeric silencing 1-like (DOT1L), a specific methyltransferase for histone H3 at lysine residue 79 (H3K79), is reported as a potential target for TNBCs, early developed nucleoside-type DOT1L inhibitors are not sufficient for effective inhibition of growth and metastasis of TNBC cells.	tyrosyl-lysine	147-153	DOT1 like histone lysine methyltransferase	Homo sapiens	251-256
31582846-2	2019	A large number of histone lysine methyltransferase (KMT) enzymes catalyze the various lysine methylation events decorating the core histone proteins.	tyrosyl-lysine	26-32	calmodulin-lysine N-methyltransferase	Homo sapiens	52-55
31582846-2	2019	A large number of histone lysine methyltransferase (KMT) enzymes catalyze the various lysine methylation events decorating the core histone proteins.	tyrosyl-lysine	86-92	calmodulin-lysine N-methyltransferase	Homo sapiens	52-55
31799324-5	2019	Large-scale phenotyping of the yeast haploid mutant collection led to the identification of 50 Com2-targets contributing to the protection against SO2 including all the genes that compose the sulfate reduction pathway (MET3, MET14, MET16, MET5, MET10) and the majority of the genes required for biosynthesis of lysine (LYS2, LYS21, LYS20, LYS14, LYS4, LYS5, LYS1 and LYS9) or arginine (ARG5,6, ARG4, ARG2, ARG3, ARG7, ARG8, ORT1 and CPA1).	tyrosyl-lysine	311-317	Com2p	Saccharomyces cerevisiae S288C	95-99
31558717-5	2019	Through genetic code expansion, MKP3 is placed under optical control via two different approaches: (i) incorporation of a caged cysteine into the active site for controlling catalytic activity and (ii) incorporation of a caged lysine into the kinase interaction motif for controlling the protein-protein interaction between the phosphatase and its substrate.	tyrosyl-lysine	227-233	dual specificity phosphatase 6	Homo sapiens	32-36
31611905-3	2019	This study is aimed at improving lysine and tryptophan content by transferring opaque-2 (o2) gene from donor HKI163 to beta-carotene-rich inbred lines viz., UMI1200beta+ and UMI1230beta+.	tyrosyl-lysine	33-39	regulatory protein opaque-2	Zea mays	79-87
31551408-7	2019	Furthermore, binding of DNMT1, DNMT3B, and EZH2 to the promoter region of p16INK4A decreased in PM2.5-treated keratinocytes, whereas TET1 and MLL1 binding increased, leading to decreased histone H3 lysine 27 trimethylation (H3K27Me3) and increased H3K4Me3 in the promoter of p16INK4A.	tyrosyl-lysine	198-204	DNA methyltransferase 1	Homo sapiens	24-29
31551408-7	2019	Furthermore, binding of DNMT1, DNMT3B, and EZH2 to the promoter region of p16INK4A decreased in PM2.5-treated keratinocytes, whereas TET1 and MLL1 binding increased, leading to decreased histone H3 lysine 27 trimethylation (H3K27Me3) and increased H3K4Me3 in the promoter of p16INK4A.	tyrosyl-lysine	198-204	cyclin dependent kinase inhibitor 2A	Homo sapiens	74-82
31942456-3	2019	Here we perform the chemical ubiquitylation of NEMO using a ligation auxiliary, which only requires a two-step synthesis, and is easily installed onto the lysine side-chain.	tyrosyl-lysine	155-161	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	47-51
31572374-8	2019	Our mutagenesis study also suggests a lysine in the top of TM3, K1303.26, to be important for G protein signaling, but not beta-arrestin-2 recruitment.	tyrosyl-lysine	38-44	tropomyosin 3	Homo sapiens	59-62
31571902-7	2019	Mechanistically, DUXAP8 repressed tumor suppressor KLF2 transcription through interacting with histone-lysine N-methyltransferase enzyme enhancer of zeste homolog 2.	tyrosyl-lysine	103-109	double homeobox A pseudogene 8	Homo sapiens	17-23
31571902-7	2019	Mechanistically, DUXAP8 repressed tumor suppressor KLF2 transcription through interacting with histone-lysine N-methyltransferase enzyme enhancer of zeste homolog 2.	tyrosyl-lysine	103-109	Kruppel like factor 2	Homo sapiens	51-55
31686850-3	2019	Here, we aim to investigate the feasibility of using serum circSETDB1, a tumor-promoting circRNA generated from the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1), known to be upregulated in SOC,as a biomarker for detecting SOC progression, predicting relapse, and evaluating the effectiveness of SOC treatment.	tyrosyl-lysine	146-152	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	63-69
31943990-0	2019	Use of Serine/Threonine Ligation for the Total Chemical Synthesis of HMGA1a Protein with Site-Specific Lysine Acetylations.	tyrosyl-lysine	103-109	high mobility group AT-hook 1	Homo sapiens	69-75
31816138-3	2020	The core subunits EZH1/2 are histone-lysine N-methyltransferases that function as the enzymatic component of PRC2.	tyrosyl-lysine	37-43	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	18-24
32001430-8	2019	Results: The additional use of thiotriazolin and L-lysine escinate significantly influenced the adiponectin concentration level.	tyrosyl-lysine	49-66	adiponectin, C1Q and collagen domain containing	Homo sapiens	96-107
31687648-3	2019	Extracellular lysyl oxidase (LOX) catalyzes the oxidative deamination of hydroxylysine and lysine residues in collagens resulting in aldehydes that subsequently form critically important biosynthetic crosslinks that stabilize functional collagens.	tyrosyl-lysine	80-86	lysyl oxidase	Mus musculus	29-32
32055215-4	2019	Feed conversion ratio (FCR) was lower in chickens fed with high Lys or high Lys + Thr diet than in those on the control diet.	tyrosyl-lysine	64-67	FCR	Gallus gallus	0-21
32055215-4	2019	Feed conversion ratio (FCR) was lower in chickens fed with high Lys or high Lys + Thr diet than in those on the control diet.	tyrosyl-lysine	64-67	FCR	Gallus gallus	23-26
32055215-4	2019	Feed conversion ratio (FCR) was lower in chickens fed with high Lys or high Lys + Thr diet than in those on the control diet.	tyrosyl-lysine	76-79	FCR	Gallus gallus	0-21
32055215-4	2019	Feed conversion ratio (FCR) was lower in chickens fed with high Lys or high Lys + Thr diet than in those on the control diet.	tyrosyl-lysine	76-79	FCR	Gallus gallus	23-26
32055215-7	2019	These results provide the first evidence on the use of high Lys in broiler diets to reduce FCR during finisher period, which may be associated with change in plasma serotonin concentration.	tyrosyl-lysine	60-63	FCR	Gallus gallus	91-94
32055215-8	2019	These findings suggest that high Lys content in finisher diet, but not high Thr + Lys diet, may affect the peripheral serotonergic metabolism and improve FCR.	tyrosyl-lysine	33-36	FCR	Gallus gallus	154-157
31746185-4	2020	Here, we show that TCF19 mediates the hepatocellular carcinoma HepG2 cell proliferation through its PHD finger that recognizes trimethylated lysine 4 of Histone 3 (H3K4me3).	tyrosyl-lysine	141-147	transcription factor 19	Homo sapiens	19-24
31719763-0	2019	Annotation of a hypothetical protein coding gene PAS_chr2-2_0152 containing Lysine Methyl transferase SMYD domain from Komagataella phaffii GS115.	tyrosyl-lysine	76-89	PAS_chr2-2_0152	Komagataella phaffii GS115	49-64
31719763-5	2019	A homology model is developed using the crystal structure of human histone-lysine methyl transferase smyd3 as template.	tyrosyl-lysine	75-88	SET and MYND domain containing 3	Homo sapiens	101-106
31943990-2	2019	To study the functions of post-translational modifications, homogeneous HMGA1a protein with site-specific lysine acetylations (64/66/70/73) has been chemically synthesized.	tyrosyl-lysine	106-112	high mobility group AT-hook 1	Homo sapiens	72-78
31564306-5	2019	The KDM7 subfamily of enzymes - PHF8 (KDM7B) and KIAA1718 (KDM7A) are human JmjC 2OG-dependent Nepsilon-methyl lysine demethylases and are involved in demethylation of lysine residues in histones such as H3K27me2/1, H3K9me2/1 and H4K20me1.	tyrosyl-lysine	111-117	PHD finger protein 8	Homo sapiens	32-36
31564306-5	2019	The KDM7 subfamily of enzymes - PHF8 (KDM7B) and KIAA1718 (KDM7A) are human JmjC 2OG-dependent Nepsilon-methyl lysine demethylases and are involved in demethylation of lysine residues in histones such as H3K27me2/1, H3K9me2/1 and H4K20me1.	tyrosyl-lysine	111-117	lysine demethylase 7A	Homo sapiens	59-64
2121685-1	1990	Supernatant obtained from granulocytes stimulated in the presence of cytochalasin B by the chemotactic peptide N-formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl- lysine displayed an inhibitory effect on the plasmin-dependent conversion of tumor urokinase-type plasminogen activator proenzyme (pro-uPA) to the active form of uPA.	tyrosyl-lysine	159-175	plasminogen activator, urokinase	Homo sapiens	304-307
2121685-1	1990	Supernatant obtained from granulocytes stimulated in the presence of cytochalasin B by the chemotactic peptide N-formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl- lysine displayed an inhibitory effect on the plasmin-dependent conversion of tumor urokinase-type plasminogen activator proenzyme (pro-uPA) to the active form of uPA.	tyrosyl-lysine	159-175	plasminogen activator, urokinase	Homo sapiens	331-334