PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8731356-3	1996	In the present study we determined whether the response to carbachol also involves AT1 receptors.	Carbachol	59-68	angiotensin II receptor, type 1a	Rattus norvegicus	83-86
8731356-6	1996	The AT1 receptor antagonist DUP-753 (50 nmol/microliters) injected into the LV reduced water intake induced by ANG II (10 nmol/microliters) from 9.2 +/- 1.4 to 0.4 +/- 0.1 ml/h (N = 8), and water intake induced by carbachol (2 nmol/microliters) from 9.8 +/- 1.4 ml/h to 3.7 +/- 0.8 ml/h (N = 8).	Carbachol	214-223	angiotensin II receptor, type 1a	Rattus norvegicus	4-7
8566594-0	1996	Epidermal growth factor inhibits carbachol-stimulated canine parietal cell function via protein kinase C. BACKGROUND & AIMS: Epidermal growth factor (EGF) inhibits secretagogue-stimulated gastric acid secretion via an EGF receptor located on parietal cells.	Carbachol	33-42	epidermal growth factor	Canis lupus familiaris	0-23
8566594-0	1996	Epidermal growth factor inhibits carbachol-stimulated canine parietal cell function via protein kinase C. BACKGROUND & AIMS: Epidermal growth factor (EGF) inhibits secretagogue-stimulated gastric acid secretion via an EGF receptor located on parietal cells.	Carbachol	33-42	epidermal growth factor	Canis lupus familiaris	129-152
8566594-0	1996	Epidermal growth factor inhibits carbachol-stimulated canine parietal cell function via protein kinase C. BACKGROUND & AIMS: Epidermal growth factor (EGF) inhibits secretagogue-stimulated gastric acid secretion via an EGF receptor located on parietal cells.	Carbachol	33-42	epidermal growth factor	Canis lupus familiaris	154-157
8566594-0	1996	Epidermal growth factor inhibits carbachol-stimulated canine parietal cell function via protein kinase C. BACKGROUND & AIMS: Epidermal growth factor (EGF) inhibits secretagogue-stimulated gastric acid secretion via an EGF receptor located on parietal cells.	Carbachol	33-42	epidermal growth factor	Canis lupus familiaris	222-225
8566594-5	1996	RESULTS: EGF dose dependently inhibited carbachol-stimulated aminopyrine uptake in a pertussis toxin-insensitive, genistein (tyrosine kinase inhibitor)--sensitive manner, with a maximal inhibitory effect (37.5% +/- 6.8%) achieved at 10(-7) mol/L.	Carbachol	40-49	epidermal growth factor	Canis lupus familiaris	9-12
8566594-10	1996	CONCLUSIONS: The inhibitory action of EGF on carbachol-stimulated parietal cell activity seems to involve protein kinase C.	Carbachol	45-54	epidermal growth factor	Canis lupus familiaris	38-41
8596502-0	1996	Glucagon-like peptide-1 stimulates insulin secretion but not phosphoinositide hydrolysis from islets desensitized by prior exposure to high glucose or the muscarinic agonist carbachol.	Carbachol	174-183	glucagon	Homo sapiens	0-23
8596502-2	1996	Compared with responses observed from control islets incubated for 3.5 hours with 5.6 mmol/L glucose alone, prior exposure to 10 mmol/L glucose, 20 mmol/L glucose, or 10 micromol/L carbachol reduced peak second-phase insulin release rates to a subsequent 20-mmol/L glucose stimulus by 63%, 81%, or 70%, respectively.	Carbachol	181-190	insulin	Homo sapiens	217-224
8596502-5	1996	Carbachol (10 micromol/L) preexposure also abolished the subsequent insulin secretory and 3H-inositol efflux responses to 8 mmol/L glucose plus 10 micromol/L carbachol.	Carbachol	0-9	insulin	Homo sapiens	68-75
8596502-5	1996	Carbachol (10 micromol/L) preexposure also abolished the subsequent insulin secretory and 3H-inositol efflux responses to 8 mmol/L glucose plus 10 micromol/L carbachol.	Carbachol	158-167	insulin	Homo sapiens	68-75
8599027-4	1996	Muscarinic stimulation with carbachol (CCh) induced a cytosolic acidification (0.15 +/- 0.01 pH unit after 5 min).	Carbachol	28-37	glucose-6-phosphate isomerase	Rattus norvegicus	93-95
8599027-4	1996	Muscarinic stimulation with carbachol (CCh) induced a cytosolic acidification (0.15 +/- 0.01 pH unit after 5 min).	Carbachol	39-42	glucose-6-phosphate isomerase	Rattus norvegicus	93-95
8599027-5	1996	Cu2+ enhanced the CCh-stimulated acidification 2-fold (0.30 +/- 0.02 pH unit after 5 min).	Carbachol	18-21	glucose-6-phosphate isomerase	Rattus norvegicus	69-71
8573085-0	1996	Asymmetric signal transduction in polarized ileal Na(+)-absorbing cells: carbachol activates brush-border but not basolateral-membrane PIP2-PLC and translocates PLC-gamma 1 only to the brush border.	Carbachol	73-82	phospholipase C gamma 1	Homo sapiens	161-172
8573085-7	1996	Western analysis and immunoprecipitation demonstrated that PLC-gamma 1 is present in the brush border and that carbachol increases the PLC-gamma 1 amount in the brush border.	Carbachol	111-120	phospholipase C gamma 1	Homo sapiens	135-146
8573085-12	1996	These studies demonstrate that carbachol but not Ca2+ ionophore effects on brush-border NaCl absorption are associated with increases in brush-border but not BLM PIP2-specific PLC activity and in the amount of brush-border PLC-gamma 1, and involve tyrosine phosphorylation.	Carbachol	31-40	phospholipase C gamma 1	Homo sapiens	223-234
8786004-1	1996	Smooth muscle cells isolated from cecal circular smooth muscle of the guinea pig were used to determine whether thyrotropin-releasing hormone (TRH) can inhibit the contractile response produced by 10(-6) M carbachol by exerting a direct action on muscle cells.	Carbachol	206-215	thyrotropin releasing hormone	Cavia porcellus	112-141
8786004-1	1996	Smooth muscle cells isolated from cecal circular smooth muscle of the guinea pig were used to determine whether thyrotropin-releasing hormone (TRH) can inhibit the contractile response produced by 10(-6) M carbachol by exerting a direct action on muscle cells.	Carbachol	206-215	thyrotropin releasing hormone	Cavia porcellus	143-146
8786004-3	1996	TRH inhibited the contractile response produced by 10(-6) M carbachol in a concentration-dependent manner, with an IC50 value of 4 nM, 2",5"-Dideoxyadenosine and phorbol 12-myristate 13-acetate did not have any significant effect on the TRH-induced relaxation.	Carbachol	60-69	thyrotropin releasing hormone	Cavia porcellus	0-3
8786004-3	1996	TRH inhibited the contractile response produced by 10(-6) M carbachol in a concentration-dependent manner, with an IC50 value of 4 nM, 2",5"-Dideoxyadenosine and phorbol 12-myristate 13-acetate did not have any significant effect on the TRH-induced relaxation.	Carbachol	60-69	thyrotropin releasing hormone	Cavia porcellus	237-240
8682156-5	1996	The addition of vasoactive intestinal peptide (VIP; 10(-9) to 10(-7) mol L(-1)) or of histamine (10(-5) to 10(-3) mol L(-1)) increased PAF production by three- to fivefold, while the addition of carbachol (10(-7) to 10(-4) mol L(-1)) increased PAF production up to sevenfold.	Carbachol	195-204	vasoactive intestinal peptide	Homo sapiens	16-45
8682156-8	1996	This is the first report showing PAF production by gastric epithelial cells in response to histamine, VIP and carbachol.	Carbachol	110-119	PCNA clamp associated factor	Homo sapiens	33-36
8713465-4	1996	During intracellular recordings from CA1 pyramidal cells in hippocampal slices from rats, the cholinergic agonist carbachol caused several reversible changes in the action potential: low doses (2 microM) caused an increase in spike duration; high doses (10-40 microM) or long-lasting applications also reduced the spike amplitude and rate of rise, and raised the spike threshold.	Carbachol	114-123	carbonic anhydrase 1	Rattus norvegicus	37-40
8801525-0	1996	Change in subcellular localization of gastrin-like immunoreactivity in epithelial cells of rat duodenum induced by carbachol.	Carbachol	115-124	gastrin	Rattus norvegicus	38-45
8801525-6	1996	However, in carbachol-stimulated animals, immunogold labeling as well as DAB reactions were accumulated at the apical portion of the cytoplasm, suggesting that a high concentration of gastrin was involved in the apical cytoplasm.	Carbachol	12-21	gastrin	Rattus norvegicus	184-191
8801525-9	1996	These findings suggest that the gastrin-like immunoreactivity was pooled at the matrix of apical cytoplasm in carbachol-stimulated cells, which might be derived from the secretory granules migrated from the basal cytoplasm into apical portion of the cells.	Carbachol	110-119	gastrin	Rattus norvegicus	32-39
8801525-10	1996	In conclusion, the present study demonstrated the change in subcellular localization of gastrin-like immunoreactivity in intestinal gastrin cells after stimulation with carbachol.	Carbachol	169-178	gastrin	Rattus norvegicus	88-95
8801525-10	1996	In conclusion, the present study demonstrated the change in subcellular localization of gastrin-like immunoreactivity in intestinal gastrin cells after stimulation with carbachol.	Carbachol	169-178	gastrin	Rattus norvegicus	132-139
9259051-3	1996	We have now found in rat aorta that carbachol, a muscarinic cholinergic agonist that promotes release of nitric oxide (NO), inhibits expression of c-fos and c-jun mRNA induced by alpha 1 receptors.	Carbachol	36-45	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	147-152
9259051-4	1996	NO synthase inhibitors blocked the effects of carbachol on c-fos mRNA and a cGMP analog mimicked carbachol.	Carbachol	46-55	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-64
8788942-15	1995	The rate of myoblast fusion was increased by carbachol, an effect antagonized by alpha-bungarotoxin, curare and decamethonium, but not by atropine, indicating that nAChR were involved.	Carbachol	45-54	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	164-169
8974845-15	1995	These results indicate that PGE2 receptor EP2 subtype, but not PGF2 alpha receptor, is involved in the inhibition (hence relaxation by inference) of carbachol-induced porcine ciliary muscle cell contraction.	Carbachol	149-158	prostaglandin E receptor 2	Homo sapiens	42-45
8745167-6	1995	Tandospirone suppressed carbachol-stimulated phosphatidyl-inositol metabolism (PI response), which was shown to be a 5-HT1A receptor-mediated event.	Carbachol	24-33	5-hydroxytryptamine receptor 1A	Rattus norvegicus	117-123
8847629-11	1995	In the presence of La3+, the caffeine response in the guinea-pig ureter and carbachol response in the rat ureter, elicited in Ca(2+)-free solutions, were always increased and prolonged and could be repeatedly evoked, suggesting similarity in Ca2+ uptake behaviour of the store in both species.	Carbachol	76-85	carbonic anhydrase 2	Rattus norvegicus	242-245
8847629-14	1995	However, ryanodine failed to prevent the rat ureter responding to carbachol, suggesting that carbachol was releasing Ca2+ from a ryanodine-insensitive channel in the sarcoplasmic reticulum (SR).	Carbachol	93-102	carbonic anhydrase 2	Rattus norvegicus	117-120
7492301-7	1995	In addition, regulated mucin secretion by LS180 cells was studied in response to carbachol, phorbol 12-myristate 13-acetate and A23187.	Carbachol	81-90	LOC100508689	Homo sapiens	23-28
7592809-7	1995	Xenopus oocytes injected with M2 muscarinic receptor (M2) plus either GIRK2 or CIR cRNA expressed only very small carbachol-induced currents, while co-injection of CIR plus GIRK2 along with M2 resulted in expression of carbachol-activated strong inwardly rectifying currents.	Carbachol	219-228	corepressor interacting with RBPJ, 1 L homeolog	Xenopus laevis	164-167
7592840-10	1995	Fetal calf serum, phenylephrine, and carbachol were less potent activators of c-Raf and A-Raf.	Carbachol	37-46	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	78-83
7592840-10	1995	Fetal calf serum, phenylephrine, and carbachol were less potent activators of c-Raf and A-Raf.	Carbachol	37-46	A-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	88-93
7592809-7	1995	Xenopus oocytes injected with M2 muscarinic receptor (M2) plus either GIRK2 or CIR cRNA expressed only very small carbachol-induced currents, while co-injection of CIR plus GIRK2 along with M2 resulted in expression of carbachol-activated strong inwardly rectifying currents.	Carbachol	219-228	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	173-178
7595517-4	1995	The dose dependency for carbachol stimulation of PtdIns synthase and phospholipase C was similar (EC50 approximately 20 microM) as was the relative intrinsic activity of muscarinic receptor partial agonists.	Carbachol	24-33	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	49-64
7491942-6	1995	These data led to the following conclusions: 1) PACAP was more potent than either carbachol or VIP in enhancing the secretion of catecholamine from the adrenal medulla, and 2) PACAP-induced catecholamine secretion was due to the direct action of PACAP on the adrenal medulla rather than an indirect action mediated by acetylcholine release.	Carbachol	82-91	adenylate cyclase activating polypeptide 1	Rattus norvegicus	176-181
7491942-6	1995	These data led to the following conclusions: 1) PACAP was more potent than either carbachol or VIP in enhancing the secretion of catecholamine from the adrenal medulla, and 2) PACAP-induced catecholamine secretion was due to the direct action of PACAP on the adrenal medulla rather than an indirect action mediated by acetylcholine release.	Carbachol	82-91	adenylate cyclase activating polypeptide 1	Rattus norvegicus	176-181
8654498-6	1995	The magnitude of the contraction caused by 10(-8) M endothelin-1 was about 30% in the longitudinal muscle strips and 29% in the circular muscle strips, relative to the contraction caused by 10(-5) M carbachol, a muscarinic agonist.	Carbachol	199-208	endothelin 1	Bos taurus	52-64
7595498-3	1995	Pretreatment of cells with a maximal effective concentration (5 microM) of BK did not affect the subsequent carbachol (CCh)-induced [Ca2+]i rise, but CCh (1 mM) pretreatment completely abolished the BK-induced [Ca2+]i rise without inhibition of BK-induced inositol 1,4,5-trisphosphate (IP3) generation.	Carbachol	150-153	kininogen 1	Homo sapiens	199-201
7595498-3	1995	Pretreatment of cells with a maximal effective concentration (5 microM) of BK did not affect the subsequent carbachol (CCh)-induced [Ca2+]i rise, but CCh (1 mM) pretreatment completely abolished the BK-induced [Ca2+]i rise without inhibition of BK-induced inositol 1,4,5-trisphosphate (IP3) generation.	Carbachol	150-153	kininogen 1	Homo sapiens	199-201
7595498-5	1995	However, the addition of atropine at plateau phases of CCh-induced [Ca2+]i rise and IP3 production caused a rapid decline to the basal levels and then restored the [Ca2+]i rise by BK.	Carbachol	55-58	kininogen 1	Homo sapiens	180-182
8868061-4	1995	The nAChR single channel properties were investigated in the presence of carbachol (1 microM) in the pipette.	Carbachol	73-82	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	4-9
7557075-7	1995	ANP and VIP inhibited 1 mumol/L carbachol-induced contraction in a dose-dependent manner.	Carbachol	32-41	VIP peptides	Cavia porcellus	8-11
8751075-5	1995	In the carbachol-precontracted guinea-pig taenia coli, reactive red 2 (0.1 to 10 microM) shifted the concentration-response curve for the P2Y-purinoceptor-mediated relaxation effect of adenosine 5"-O-(2-thiodiphosphate) (ADP beta S) progressively to the right; only at the highest concentration of antagonist (10 microM) was the maximum slightly depressed; a pA2 value of 7.55 (Kd 0.028 microM) was derived from the shift.	Carbachol	7-16	adenosine deaminase, RNA-specific, B2	Rattus norvegicus	64-69
7557088-9	1995	[Ca2+]i chelator and calmodulin antagonist inhibited the carbachol-induced pepsinogen secretion and NO generation.	Carbachol	57-66	calmodulin 1	Homo sapiens	21-31
8569054-2	1995	Carbachol stimulated the release of histamine and the activity of HDC with 30-50% the intensity of the maximal effect of the antigen.	Carbachol	0-9	histidine decarboxylase	Homo sapiens	66-69
7476883-0	1995	Phosphorylation of cyclic AMP response element-binding protein and induction of c-fos gene expression on withdrawal from chronic treatment with carbachol in NG108-15 cells.	Carbachol	144-153	FBJ osteosarcoma oncogene	Mus musculus	80-85
7476883-6	1995	In cells treated with carbachol for 48 hr, induction of withdrawal with the muscarinic antagonist atropine led to a small increase in intracellular cAMP concentration but an 11.6-fold increase in the phosphorylation of CREB and a 3.4-fold increase in accumulation of c-fos mRNA.	Carbachol	22-31	cAMP responsive element binding protein 1	Mus musculus	219-223
7476883-6	1995	In cells treated with carbachol for 48 hr, induction of withdrawal with the muscarinic antagonist atropine led to a small increase in intracellular cAMP concentration but an 11.6-fold increase in the phosphorylation of CREB and a 3.4-fold increase in accumulation of c-fos mRNA.	Carbachol	22-31	FBJ osteosarcoma oncogene	Mus musculus	267-272
7476883-7	1995	The adenylyl cyclase inhibitor 2",5"-dideoxyadenosine, which attenuated the chronic carbachol-induced increase in cAMP concentration, prevented the increased phosphorylation of CREB and the enhanced accumulation of c-fos mRNA during atropine-induced withdrawal.	Carbachol	84-93	cAMP responsive element binding protein 1	Mus musculus	177-181
7476883-7	1995	The adenylyl cyclase inhibitor 2",5"-dideoxyadenosine, which attenuated the chronic carbachol-induced increase in cAMP concentration, prevented the increased phosphorylation of CREB and the enhanced accumulation of c-fos mRNA during atropine-induced withdrawal.	Carbachol	84-93	FBJ osteosarcoma oncogene	Mus musculus	215-220
8570026-4	1995	Carbachol-induced responses were antagonized by both atropine and mecamylamine in a manner consistent with agonist effects of carbachol at both nicotinic and muscarinic sites, while concentration-effect curves to DMPP and muscarine were shifted rightward in a parallel manner by mecamylamine (10 microM) and atropine (5 nM), with antagonist pKB estimates of 6.4 and 9.0, respectively.	Carbachol	0-9	AKT serine/threonine kinase 1	Homo sapiens	341-344
7578678-1	1995	In the present study, we have determined the influence of tumor necrosis factor alpha (TNF alpha) on both basal and carbamylcholine chloride (Cch)-induced [Ca2+]i in granulosa cells from the largest (F1) and smallest (F5,6) preovulatory follicles.	Carbachol	116-140	tumor necrosis factor	Homo sapiens	58-85
7578678-1	1995	In the present study, we have determined the influence of tumor necrosis factor alpha (TNF alpha) on both basal and carbamylcholine chloride (Cch)-induced [Ca2+]i in granulosa cells from the largest (F1) and smallest (F5,6) preovulatory follicles.	Carbachol	116-140	tumor necrosis factor	Homo sapiens	87-96
7578678-1	1995	In the present study, we have determined the influence of tumor necrosis factor alpha (TNF alpha) on both basal and carbamylcholine chloride (Cch)-induced [Ca2+]i in granulosa cells from the largest (F1) and smallest (F5,6) preovulatory follicles.	Carbachol	142-145	tumor necrosis factor	Homo sapiens	58-85
7578678-1	1995	In the present study, we have determined the influence of tumor necrosis factor alpha (TNF alpha) on both basal and carbamylcholine chloride (Cch)-induced [Ca2+]i in granulosa cells from the largest (F1) and smallest (F5,6) preovulatory follicles.	Carbachol	142-145	tumor necrosis factor	Homo sapiens	87-96
7578678-6	1995	Pretreatment with TNF alpha (4-5 min) increased the magnitude of the Cch response in both F1 and F5,6 granulosa cells previously incapable of producing large Cch-induced changes in [Ca2+]i.	Carbachol	69-72	tumor necrosis factor	Homo sapiens	18-27
7578678-6	1995	Pretreatment with TNF alpha (4-5 min) increased the magnitude of the Cch response in both F1 and F5,6 granulosa cells previously incapable of producing large Cch-induced changes in [Ca2+]i.	Carbachol	158-161	tumor necrosis factor	Homo sapiens	18-27
7578678-7	1995	In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously.	Carbachol	41-44	tumor necrosis factor	Homo sapiens	28-37
7578678-7	1995	In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously.	Carbachol	41-44	tumor necrosis factor	Homo sapiens	132-141
7578678-7	1995	In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously.	Carbachol	100-103	tumor necrosis factor	Homo sapiens	28-37
7578678-7	1995	In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously.	Carbachol	100-103	tumor necrosis factor	Homo sapiens	132-141
7578678-7	1995	In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously.	Carbachol	100-103	tumor necrosis factor	Homo sapiens	28-37
7578678-7	1995	In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously.	Carbachol	100-103	tumor necrosis factor	Homo sapiens	132-141
7578678-8	1995	Furthermore, the TNF alpha effect was reversible, as subsequent challenge with Cch in the absence of TNF alpha failed to produce the large Ca(2+)-transients observed earlier with the cytokine present.	Carbachol	79-82	tumor necrosis factor	Homo sapiens	17-26
8637618-0	1995	The association of thirst, sodium appetite and vasopressin release with c-fos expression in the forebrain of the rat after intracerebroventricular injection of angiotensin II, angiotensin-(1-7) or carbachol.	Carbachol	197-206	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-77
8637618-1	1995	The effect intracerebroventricular injections of angiotensin II (0.1 nm), angiotensin-(1-7) (1 or 100 nm) and carbachol (500 ng) on c-fos expression was examined in the forebrain of Lister hooded rats.	Carbachol	110-119	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	132-137
8637618-14	1995	Angiotensin II and carbachol caused an approximate five-fold increase in plasma vasopressin levels compared to cerebrospinal fluid-injected rats, but angiotensin-(1-7) had no effect on vasopressin release.	Carbachol	19-28	arginine vasopressin	Rattus norvegicus	80-91
8788591-5	1995	Carbachol increased the concentration and the transcription rate of alpha Gi1-mRNA and [1,4,5]IP3R-mRNA both in neonatal and adult samples.	Carbachol	0-9	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	94-98
8788591-10	1995	Carbachol increases the steady-state concentration of both alpha Gi1-mRNA and [1,4,5]IP3R-mRNA possibly by altering their synthesis and stability in brain.	Carbachol	0-9	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	85-89
7578678-10	1995	In addition, TNF alpha appeared to enhance Cch-induced mobilization of Ca2+ from intracellular stores.	Carbachol	43-46	tumor necrosis factor	Homo sapiens	13-22
7654194-1	1995	Chinese hamster ovary cells stably transfected with human M3 muscarinic acetylcholine receptors show a 40-50% reduction in the immunoreactive G-proteins Gq alpha and G11 alpha when stimulated with the cholinergic agonist carbachol.	Carbachol	221-230	cholinergic receptor muscarinic 3	Homo sapiens	58-95
7654194-3	1995	The effect is specific for Gq alpha family proteins as Gs alpha was slightly increased after carbachol treatment and G13 alpha was unchanged.	Carbachol	93-102	GNAS complex locus	Homo sapiens	55-63
7557261-0	1995	Carbachol-induced desensitization of rat basophilic leukemia (RBL-2H3) cells transfected with human m3 muscarinic acetylcholine receptors.	Carbachol	0-9	cholinergic receptor muscarinic 3	Homo sapiens	100-137
7477901-0	1995	Fos and serotonin immunoreactivity in the raphe nuclei of the cat during carbachol-induced active sleep: a double-labeling study.	Carbachol	73-82	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	0-3
8570018-0	1995	Activation of 5-HT1A receptors inhibits carbachol-stimulated inositol 1,4,5-trisphosphate mass accumulation in the rodent hippocampus.	Carbachol	40-49	5-hydroxytryptamine receptor 1A	Rattus norvegicus	14-20
8570018-1	1995	We have previously demonstrated that 5-HT1A receptor agonists partially prevent the stimulation by carbachol of [3H]-phosphoinositide hydrolysis in immature rat hippocampal slices.	Carbachol	99-108	5-hydroxytryptamine receptor 1A	Rattus norvegicus	37-43
8570018-3	1995	In hippocampal slices from developing rats and in hippocampal neurons, carbachol enhanced the accumulation of IP3 and this response was partially inhibited by 8-OH-DPAT with a potency compatible with the affinity of this agonist for 5-HT1A receptors.	Carbachol	71-80	5-hydroxytryptamine receptor 1A	Rattus norvegicus	233-239
7501705-5	1995	In the current study, we investigated the effect of Mg2+ on the contraction and intracellular free calcium of rabbit urinary bladder detrusor muscle in response to carbachol and transmural field stimulation (FS).	Carbachol	164-173	mucin 7, secreted	Homo sapiens	52-55
7650010-1	1995	mAChR-stimulated PLD was turned off after 2 min of receptor activation with either the full (carbachol) or partial agonist (pilocarpine) and remained completely suppressed for at least 4 h. Partial recovery was observed 24 h after agonist removal.	Carbachol	93-102	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
8584207-5	1995	Microinfusion of muscarinic agonist, carbachol, induced Fos expression as well, but mostly in the oxytocin neurons.	Carbachol	37-46	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-59
7653652-9	1995	These data provide the first demonstration that adenylyl cyclase within the mPRF contributes to the carbachol induction of REM sleep and respiratory depression.	Carbachol	100-109	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	76-80
7590625-2	1995	TRH inhibited carbachol (10(-5) M)-stimulated amylase secretion by a maximum of 24% at a concentration of 10(-11) M (p < 0.05), but did not affect basal amylase release in concentrations from 10(-13) M to 10(-8) M. Ceruletide (3 x 10(-10) M)-stimulated amylase secretion was maximally reduced by 23% at a TRH concentration of 10(-10) M (p < 0.05).	Carbachol	14-23	thyrotropin releasing hormone	Rattus norvegicus	0-3
7590625-2	1995	TRH inhibited carbachol (10(-5) M)-stimulated amylase secretion by a maximum of 24% at a concentration of 10(-11) M (p < 0.05), but did not affect basal amylase release in concentrations from 10(-13) M to 10(-8) M. Ceruletide (3 x 10(-10) M)-stimulated amylase secretion was maximally reduced by 23% at a TRH concentration of 10(-10) M (p < 0.05).	Carbachol	14-23	thyrotropin releasing hormone	Rattus norvegicus	308-311
7482289-0	1995	Corticosteroid-mediated modulation of carbachol responsiveness in CA1 pyramidal neurons: a voltage clamp analysis.	Carbachol	38-47	carbonic anhydrase 1	Rattus norvegicus	66-69
7625999-1	1995	Carbachol stimulation of the muscarinic acetylcholine m1 receptor (m1R), stably expressed in Rat 1a fibroblasts, resulted in a calcium-dependent activation of c-Jun kinase (JNK).	Carbachol	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	173-176
7626007-4	1995	Activation of MAPK and MAPK kinase (MEK) by carbachol returned to control levels within 30-60 min, whereas activation by FCS was more sustained.	Carbachol	44-53	mitogen activated protein kinase 3	Rattus norvegicus	14-18
7626007-4	1995	Activation of MAPK and MAPK kinase (MEK) by carbachol returned to control levels within 30-60 min, whereas activation by FCS was more sustained.	Carbachol	44-53	mitogen activated protein kinase 3	Rattus norvegicus	23-27
7626007-5	1995	FPLC on Mono Q showed that carbachol and FCS activated two peaks of MEK and two peaks of MAPK (p42MAPK and p44MAPK).	Carbachol	27-36	mitogen activated protein kinase 3	Rattus norvegicus	89-93
7626007-5	1995	FPLC on Mono Q showed that carbachol and FCS activated two peaks of MEK and two peaks of MAPK (p42MAPK and p44MAPK).	Carbachol	27-36	mitogen activated protein kinase 1	Rattus norvegicus	95-102
7626007-5	1995	FPLC on Mono Q showed that carbachol and FCS activated two peaks of MEK and two peaks of MAPK (p42MAPK and p44MAPK).	Carbachol	27-36	mitogen activated protein kinase 3	Rattus norvegicus	107-114
7626007-6	1995	Pretreatment of cells with PTX for 24 h inhibited the activation of MAPK by carbachol, FCS and lysophosphatidic acid, but not that by endothelin-1, phenylephrine or isoprenaline.	Carbachol	76-85	mitogen activated protein kinase 3	Rattus norvegicus	68-72
7583249-3	1995	Surprisingly, superfusion or local application of low concentrations of acetylcholine (ACh), carbachol (CCh) or muscarine reduced the amplitudes of CA1 field potentials evoked by stratum radiatum (SR) stimulation.	Carbachol	93-102	carbonic anhydrase 1	Rattus norvegicus	148-151
7583249-3	1995	Surprisingly, superfusion or local application of low concentrations of acetylcholine (ACh), carbachol (CCh) or muscarine reduced the amplitudes of CA1 field potentials evoked by stratum radiatum (SR) stimulation.	Carbachol	104-107	carbonic anhydrase 1	Rattus norvegicus	148-151
7587302-0	1995	Effect of carbachol on phospholipase C-mediated phosphatidylinositol 4,5-bisphosphate hydrolysis, and its modulation by isoproterenol in rabbit corneal epithelial cells.	Carbachol	10-19	LOC100009319	Oryctolagus cuniculus	23-38
7587302-1	1995	The effects of carbachol (CCh) on phospholipase C(PLC)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis and its modulation by isoproterenol were investigated in SV40-adenovirus transformed rabbit corneal epithelial cells (RCEC).	Carbachol	15-24	LOC100009319	Oryctolagus cuniculus	34-49
7587302-1	1995	The effects of carbachol (CCh) on phospholipase C(PLC)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis and its modulation by isoproterenol were investigated in SV40-adenovirus transformed rabbit corneal epithelial cells (RCEC).	Carbachol	26-29	LOC100009319	Oryctolagus cuniculus	34-49
7494138-5	1995	Preincubation of the SAN cells with L-nitro-arginine methyl ester (L-NAME; 0.2-1 mM), which inhibits NO synthase (NOS), abolished the CCh-induced attenuation of ICa(L) but had no effect on IK(ACh).	Carbachol	134-137	nitric oxide synthase 2	Homo sapiens	101-112
8567506-7	1995	Subsequently, we found that sheep developed airway hyperresponsiveness to inhaled carbachol at 4 and 24 h after ET-1 challenge, an effect that was blocked by aerosolized BQ-123.	Carbachol	82-91	endothelin-1	Ovis aries	112-116
7478930-0	1995	Role of calmodulin in the activation of carbachol-activated cationic current in guinea-pig gastric antral myocytes.	Carbachol	40-49	calmodulin-2	Cavia porcellus	8-18
7478930-10	1995	These data suggest that multiple Ca2+-dependent pathways are involved in the activation of CCh-gated cation channels in guinea-pig antral myocytes and a Ca2+/calmodulin-dependent pathway would be one of them.	Carbachol	91-94	calmodulin-2	Cavia porcellus	158-168
7662698-4	1995	Heavy staining with the antibody for autophosphorylated CaMK II was observed in the cytoplasm of chief cells treated with carbamylcholine chloride or ionomycin, but only light staining was seen in cells treated with TPA or forskolin.	Carbachol	122-146	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	56-63
8528696-3	1995	As 5-HT, GABA-, and CCh-stimulated high-affinity GTPase activities are mediated by the 5-HT1A, GABAB, and pirenzepine-insensitive muscarinic receptors, respectively, the additive effects indicate that these three receptors are independently coupled to distinct pools of G proteins.	Carbachol	20-23	5-hydroxytryptamine receptor 1A	Rattus norvegicus	87-93
7625999-1	1995	Carbachol stimulation of the muscarinic acetylcholine m1 receptor (m1R), stably expressed in Rat 1a fibroblasts, resulted in a calcium-dependent activation of c-Jun kinase (JNK).	Carbachol	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	159-171
7477901-3	1995	Compared with control cats, which were injected with saline, active sleep-carbachol cats exhibited a significantly greater number of c-fos-expressing neurons in the raphe dorsalis, magnus and pallidus.	Carbachol	74-83	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	133-138
7611446-4	1995	We observed that, like in the glomerulus, endothelin and PAF induced, in the parietal sheet, [Ca2+]i responses that differed in many respects from those found with carbachol.	Carbachol	164-173	PCNA clamp associated factor	Rattus norvegicus	57-60
7477901-6	1995	These data indicate that there is an increased number of non-serotonergic, c-fos-expressing neurons in the raphe dorsalis, magnus and pallidus during the carbachol-induced state.	Carbachol	154-163	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	75-80
7539427-0	1995	Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells.	Carbachol	0-9	protein kinase C delta	Homo sapiens	82-104
7539427-2	1995	In response to substance P and the muscarinic agonist carbachol, two ligands that activate phospholipase C-linked receptors, which stimulate fluid secretion, PKC delta was phosphorylated on tyrosine residues.	Carbachol	54-63	protein kinase C delta	Homo sapiens	158-167
7494138-7	1995	In the presence of ISO the CCh-induced inhibition of ICa(L) could be mimicked by the NO donor 3-morpholino-sydnonimine (SIN-1; 0.1 mM).	Carbachol	27-30	MAPK associated protein 1	Homo sapiens	120-125
7611446-2	1995	The aim of the present work was to investigate whether this structure could be also a target of endothelin and platelet-activating factor (PAF), since we observed [Ca2+]i increases in response to both agonists in the glomerulus, but which were very different from that induced by carbachol.	Carbachol	280-289	PCNA clamp associated factor	Rattus norvegicus	111-137
7611446-2	1995	The aim of the present work was to investigate whether this structure could be also a target of endothelin and platelet-activating factor (PAF), since we observed [Ca2+]i increases in response to both agonists in the glomerulus, but which were very different from that induced by carbachol.	Carbachol	280-289	PCNA clamp associated factor	Rattus norvegicus	139-142
7611446-5	1995	Thus, in the presence of 2 mM external calcium, 1) endothelin and PAF responses spontaneously declined to basal level, whereas a stationary plateau was observed after a sharp peak of [Ca2+]i with carbachol; 2) the magnitude of [Ca2+]i peak was smaller with endothelin and PAF than with carbachol; and 3) endothelin and PAF, but not carbachol, induced a homologous dose-dependent desensitization.	Carbachol	286-295	PCNA clamp associated factor	Rattus norvegicus	66-69
7611446-5	1995	Thus, in the presence of 2 mM external calcium, 1) endothelin and PAF responses spontaneously declined to basal level, whereas a stationary plateau was observed after a sharp peak of [Ca2+]i with carbachol; 2) the magnitude of [Ca2+]i peak was smaller with endothelin and PAF than with carbachol; and 3) endothelin and PAF, but not carbachol, induced a homologous dose-dependent desensitization.	Carbachol	286-295	PCNA clamp associated factor	Rattus norvegicus	66-69
7751925-6	1995	Compared to vehicle- and carbachol-treated animals without REMc, the animals with REMc showed a significantly higher number of Fos-LI cells in pontine regions that have been implicated in REM sleep generation.	Carbachol	25-34	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	127-130
7730640-3	1995	Stimulation of these cells with Ag, carbachol, Ca(2+)-ionophore, or thapsigargin resulted in the phosphorylation of Raf1, MEK1, p42mapk MAP kinase, and the recently cloned cytosolic phospholipase A2 (PLA2) and increased activities of both MAP kinase and PLA2, as well as release of arachidonic acid.	Carbachol	36-45	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	116-120
7730640-3	1995	Stimulation of these cells with Ag, carbachol, Ca(2+)-ionophore, or thapsigargin resulted in the phosphorylation of Raf1, MEK1, p42mapk MAP kinase, and the recently cloned cytosolic phospholipase A2 (PLA2) and increased activities of both MAP kinase and PLA2, as well as release of arachidonic acid.	Carbachol	36-45	mitogen activated protein kinase kinase 1	Rattus norvegicus	122-126
7730640-3	1995	Stimulation of these cells with Ag, carbachol, Ca(2+)-ionophore, or thapsigargin resulted in the phosphorylation of Raf1, MEK1, p42mapk MAP kinase, and the recently cloned cytosolic phospholipase A2 (PLA2) and increased activities of both MAP kinase and PLA2, as well as release of arachidonic acid.	Carbachol	36-45	phospholipase A2 group IVA	Rattus norvegicus	172-198
7721739-5	1995	In contrast, in cells transfected with M1mAChRs, which effectively couple to Gq/PLC, carbachol increased ANF reporter gene expression 10-fold and also increased ANF protein, as determined by immunofluorescence.	Carbachol	85-94	natriuretic peptide A	Homo sapiens	105-108
7721739-5	1995	In contrast, in cells transfected with M1mAChRs, which effectively couple to Gq/PLC, carbachol increased ANF reporter gene expression 10-fold and also increased ANF protein, as determined by immunofluorescence.	Carbachol	85-94	natriuretic peptide A	Homo sapiens	161-164
7721739-6	1995	Carbachol-mediated ANF gene expression was inhibited by the mAChR antagonist pirenzepine with a Ki value characteristic of an M1mAChR.	Carbachol	0-9	natriuretic peptide A	Homo sapiens	19-22
7609913-5	1995	We therefore tested the effects of the cholinergic agonists acetylcholine and carbachol on excised KCa channels.	Carbachol	78-87	casein kappa	Homo sapiens	99-102
7713942-2	1995	The effect is mimicked by phorbol esters, which directly activate protein kinase C. Using human embryonic kidney cells expressing individual muscarinic receptor subtypes, we found that stimulation of APPs release by the muscarinic agonist carbachol was only partially reduced by a specific inhibitor of protein kinase C (the bisindolylmaleimide GF 109203X), while the response to phorbol 12-myristate 13-acetate (PMA) was abolished.	Carbachol	239-248	cathepsin B	Homo sapiens	200-204
7713942-3	1995	The increase in APPs release elicited by carbachol and PMA was accompanied by elevated tyrosine phosphorylation of several proteins and reduced by tyrosine kinase inhibitors; GF 109203X significantly reduced the stimulation of tyrosine phosphorylation by carbachol and PMA.	Carbachol	41-50	cathepsin B	Homo sapiens	16-20
7713942-3	1995	The increase in APPs release elicited by carbachol and PMA was accompanied by elevated tyrosine phosphorylation of several proteins and reduced by tyrosine kinase inhibitors; GF 109203X significantly reduced the stimulation of tyrosine phosphorylation by carbachol and PMA.	Carbachol	255-264	cathepsin B	Homo sapiens	16-20
7713942-6	1995	The results implicate both tyrosine phosphorylation and protein kinase C-dependent mechanisms in the regulation of APPs release by G protein-coupled receptors, and suggest that carbachol and PMA increase APPs release from human embryonic kidney cells expressing m3 muscarinic receptors via partially divergent pathways that converge at a tyrosine phosphorylation-dependent step.	Carbachol	177-186	cathepsin B	Homo sapiens	115-119
7713942-6	1995	The results implicate both tyrosine phosphorylation and protein kinase C-dependent mechanisms in the regulation of APPs release by G protein-coupled receptors, and suggest that carbachol and PMA increase APPs release from human embryonic kidney cells expressing m3 muscarinic receptors via partially divergent pathways that converge at a tyrosine phosphorylation-dependent step.	Carbachol	177-186	cathepsin B	Homo sapiens	204-208
7891088-9	1995	Together, these results suggest that both the massive influx of calcium induced by NMDA and the coupling of muscarinic receptors with a putative phospholipase A2 are required for the strong synergistic effects of carbachol and NMDA on [3H]AA release.	Carbachol	213-222	phospholipase A2 group IB	Homo sapiens	145-161
7786304-4	1995	Carbachol (1 mM) and potassium (100 mM) caused a time (T1/2 = 3 and 4 min, respectively) and dose (EC50 = 6.95 microM and 34.7 mM respectively) related increase in cAMP formation.	Carbachol	0-9	CD5 molecule	Homo sapiens	55-69
7706286-2	1995	We had previously constructed two triple point alanine mutants of the i3 junction of the muscarinic Hm1 receptor, W209A/I211A/Y212A and E360A/K362A/T366A, which are defective in mediating carbachol stimulation of phosphatidylinositol (PI) turnover (Moro, O., Lameh, J., Hogger, P., and Sadee, W. (1993) J. Biol.	Carbachol	188-197	cholinergic receptor muscarinic 1	Homo sapiens	100-103
7706902-8	1995	Repeated BK stimuli also led to partial desensitization (70% to 85%) to adenosine triphosphatase and carbachol (heterologous desensitization).	Carbachol	101-110	kininogen 1	Canis lupus familiaris	9-11
7700249-4	1995	Maximal (1 mM) carbachol concentrations abolished the elevation of [Ca2+]i produced by bradykinin but the muscarinic antagonist atropine (10 microM) restored the response, provided that extracellular Ca2+ was present throughout the experiment or was added before bradykinin.	Carbachol	15-24	kininogen 1	Homo sapiens	87-97
7700249-5	1995	Carbachol also abolished bradykinin-mediated Ins(1,4,5)P3 elevation.	Carbachol	0-9	kininogen 1	Homo sapiens	25-35
7700249-8	1995	In these cells carbachol again abolished bradykinin-mediated elevation of [Ca2+]i but only attenuated, rather than abolished, the elevation of Ins(1,4,5)P3 levels.	Carbachol	15-24	kininogen 1	Homo sapiens	41-51
7700249-10	1995	Thus, depletion of an intracellular Ins(1,4,5)P3-sensitive Ca2+ store may underlie the ability of carbachol to produce not only heterologous desensitization of the [Ca2+]i elevation induced by bradykinin but also that of the Ins(1,4,5)P3 response.	Carbachol	98-107	kininogen 1	Homo sapiens	193-203
7493606-0	1995	Caffeine and carbachol act on common Ca2+ stores to release Ca2+ in guinea-pig ileal smooth muscle.	Carbachol	13-22	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	37-40
7493606-0	1995	Caffeine and carbachol act on common Ca2+ stores to release Ca2+ in guinea-pig ileal smooth muscle.	Carbachol	13-22	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	60-63
7493606-2	1995	Caffeine (20 mM), carbachol (10 or 100 microM) or IP3 (40 microM), applied after loading Ca2+ within intracellular stores, produced a transient rise in tension in a Ca(2+)-free solution.	Carbachol	18-27	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	89-92
7493606-6	1995	The effects of carbachol and IP3 were abolished after combined treatment with ryanodine (30 microM) and caffeine (20 mM) which causes functional removal of caffeine-releasable Ca2+ stores, but not after combined treatment with ryanodine (30 microM) and carbachol (10 microM).	Carbachol	15-24	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	176-179
7493606-7	1995	The results suggest that caffeine, carbachol and IP3 all act on common Ca2+ stores to release Ca2+.	Carbachol	35-44	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	71-74
7493606-7	1995	The results suggest that caffeine, carbachol and IP3 all act on common Ca2+ stores to release Ca2+.	Carbachol	35-44	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	94-97
7887929-5	1995	Insulin secretagogues (28 mM glucose + 0.5 mM carbachol) caused a rapid and transient increase in PtdIns(3,4,5)P3 levels which peaked at 2-5 min, corresponding to peak early phase insulin release.	Carbachol	46-55	insulin	Homo sapiens	0-7
7887929-5	1995	Insulin secretagogues (28 mM glucose + 0.5 mM carbachol) caused a rapid and transient increase in PtdIns(3,4,5)P3 levels which peaked at 2-5 min, corresponding to peak early phase insulin release.	Carbachol	46-55	insulin	Homo sapiens	180-187
7890682-14	1995	In particular, carbachol caused a much greater induction of c-jun mRNA and AP-1 activity.	Carbachol	15-24	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-65
7876266-7	1995	Under these conditions, carbachol caused a time-dependent 2-fold increase in APP-S secretion into the medium.	Carbachol	24-33	cathepsin B	Homo sapiens	77-82
7876266-8	1995	In contrast, prolonged treatment with carbachol caused a decrease in A beta production into the medium.	Carbachol	38-47	amyloid beta precursor protein	Homo sapiens	69-75
7883044-6	1995	The contribution of the carbamylcholine moiety of the site-directed reducing agent was clearly demonstrated in kinetic studies where reduction abilities of ARA, DTT and the methylated analogue of ARA (MeRA) were compared.	Carbachol	24-39	ATP binding cassette subfamily C member 6	Homo sapiens	156-159
7883044-6	1995	The contribution of the carbamylcholine moiety of the site-directed reducing agent was clearly demonstrated in kinetic studies where reduction abilities of ARA, DTT and the methylated analogue of ARA (MeRA) were compared.	Carbachol	24-39	ATP binding cassette subfamily C member 6	Homo sapiens	196-199
7798903-3	1995	The neuroprotective action of 1S,3R-ACPD was prevented by the mGluR antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) and was mimicked by N-methyl-D-aspartate or carbamylcholine but not by agonists of the mGluR subtypes negatively linked to adenylyl cyclase.	Carbachol	171-186	homer scaffold protein 2	Homo sapiens	36-40
7823957-5	1995	In two astrocytoma lines of human origin, CCF and 1321N1, ets-1 phosphorylation was stimulated by bradykinin and carbachol, respectively.	Carbachol	113-122	ETS proto-oncogene 1, transcription factor	Homo sapiens	58-63
7538684-3	1995	The possible costimulation of CGRP with SP, NKA or carbachol on 5-day-old and adult rats was also tested.	Carbachol	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	30-34
7832780-11	1995	Addition of carbachol to M5-Trpl cells at 30-36 h after infection produced a large increase in [Ca2+]i to a sustained value of 677 +/- 143 nM.	Carbachol	12-21	transient receptor potential-like	Drosophila melanogaster	28-32
7814389-9	1995	We show that in astrocytoma cells, okadaic acid and cyclosporin A (an inhibitor of calcineurin) both potentiate the Ca2+ elevations due to low doses of CIF, thapsigargin, or carbachol.	Carbachol	174-183	protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog	Xenopus laevis	83-94
8580531-6	1995	Apparently, the inhibitory action of IL-2 on IFN gamma involves an impaired response or atria to cholinergic activation, as IL-2 shifts to the right the dose response curve of the tissue to the cholinergic muscarinic agonist carbachol.	Carbachol	225-234	interleukin 2	Rattus norvegicus	37-41
8580531-6	1995	Apparently, the inhibitory action of IL-2 on IFN gamma involves an impaired response or atria to cholinergic activation, as IL-2 shifts to the right the dose response curve of the tissue to the cholinergic muscarinic agonist carbachol.	Carbachol	225-234	interferon gamma	Rattus norvegicus	45-54
8580531-6	1995	Apparently, the inhibitory action of IL-2 on IFN gamma involves an impaired response or atria to cholinergic activation, as IL-2 shifts to the right the dose response curve of the tissue to the cholinergic muscarinic agonist carbachol.	Carbachol	225-234	interleukin 2	Rattus norvegicus	124-128
7840204-4	1995	The stimulatory effects of carbachol on goblet cell degranulation in isolated pancreatic ducts were blocked by atropine and enhanced by simultaneous exposure to VIP.	Carbachol	27-36	VIP peptides	Cavia porcellus	161-164
7529994-1	1995	Desensitization of rat pancreatic acinar cells with 0.1 mM carbamoylcholine (Cch) or 0.5 nM caerulein (CAE), a cholecystokinin (CCK) agonist, altered the subsequent secretory responses to these two agonists.	Carbachol	59-75	cholecystokinin	Rattus norvegicus	111-126
7712026-1	1995	The effect of tumour necrosis factor-alpha (TNF alpha) on the increase in cytosolic free calcium ([Ca2+])i induced by carbachol and bradykinin (BK) was investigated in human tracheal smooth muscle cells in culture (TSMC).	Carbachol	118-127	tumor necrosis factor	Homo sapiens	44-53
7895929-3	1995	Carbachol (10(-8) to 10(-5) M) dose-dependently stimulated gastrin release with a maximal stimulatory response achieved at a concentration of 10(-5) M (330% over basal).	Carbachol	0-9	gastrin	Canis lupus familiaris	59-66
7895929-4	1995	To characterize the muscarinic receptor which mediates gastrin release from antral G cells, we examined the effect of three muscarinic receptor antagonists on carbachol-stimulated gastrin release; atropine (nonselective muscarinic receptor antagonist), pirenzepine (M1 muscarinic receptor antagonist) and 4-DAMP (M3 muscarinic receptor antagonist).	Carbachol	159-168	gastrin	Canis lupus familiaris	180-187
7895929-6	1995	However, carbachol (10(-5) M)-stimulated gastrin release was effectively inhibited by atropine and 4-DAMP with Ki values of 0.48 and 0.66 nM, respectively.	Carbachol	9-18	gastrin	Canis lupus familiaris	41-48
7895929-7	1995	Pirenzepine at a high concentration (10(-5) M) also inhibited carbachol-stimulated gastrin release with a Ki value of 46.3 nM.	Carbachol	62-71	gastrin	Canis lupus familiaris	83-90
8587335-1	1995	The effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) were investigated on carbachol-contracted guinea-pig trachea.	Carbachol	80-89	endothelin-3	Cavia porcellus	53-57
7475951-6	1995	Biochemical assay of total PKC confirmed that cytosolic enzyme activity was significantly reduced by TPA and carbachol to 29% and 75% respectively of control levels.	Carbachol	109-118	protein kinase C, alpha	Rattus norvegicus	27-30
7803515-4	1994	Carbamylcholine and PMA caused an increase in membrane-associated alpha PKC, but did not alter the subcellular distribution of zeta PKC.	Carbachol	0-15	proline rich transmembrane protein 2	Homo sapiens	72-75
7479339-0	1995	Effect of carbachol on the release of peptide YY from isolated vascularly and luminally perfused rat ileum.	Carbachol	10-19	peptide YY	Rattus norvegicus	38-48
7479339-4	1995	Carbachol-induced release of PYY into both lumen and vasculature was completely blocked by atropine, but not by hexamethonium.	Carbachol	0-9	peptide YY	Rattus norvegicus	29-32
7479339-5	1995	Tetrodotoxin abolished carbachol-induced release of PYY into lumen and vasculature.	Carbachol	23-32	peptide YY	Rattus norvegicus	52-55
7810765-6	1994	As early as 2 min after stop-flow ischemia, the inhibitory effect of carbachol (10 microM) on the stimulation-evoked overflow of norepinephrine and NPY was lost.	Carbachol	69-78	pro-neuropeptide Y	Cavia porcellus	148-151
7536322-4	1995	Similarly, the effect of EGF on carbachol-stimulated amylase release was substantial at submaximal (0.1 microM: 44% inhibition), maximal (1 microM: 75% inhibition), and supramaximal (100 microM: 33% inhibition) carbachol concentrations.	Carbachol	32-41	epidermal growth factor like 1	Rattus norvegicus	25-28
7536322-4	1995	Similarly, the effect of EGF on carbachol-stimulated amylase release was substantial at submaximal (0.1 microM: 44% inhibition), maximal (1 microM: 75% inhibition), and supramaximal (100 microM: 33% inhibition) carbachol concentrations.	Carbachol	211-220	epidermal growth factor like 1	Rattus norvegicus	25-28
7536322-6	1995	EGF decreased the peak increase of 1,4,5-IP3 in response to bombesin and carbachol (5 s after beginning of the incubation) and bFGF (15 s after beginning of the incubation) by 81 +/- 19%, 65 +/- 15%, and 56 +/- 18%, respectively.	Carbachol	73-82	epidermal growth factor like 1	Rattus norvegicus	0-3
7810765-2	1994	The muscarinic agonists oxotremorine (0.01-1 microM) and carbachol (0.1-10 microM) reduced norepinephrine and NPY overflow in a concentration-dependent manner to approximately 30% of control.	Carbachol	57-66	pro-neuropeptide Y	Cavia porcellus	110-113
7810765-7	1994	On reperfusion with oxygenated buffer after 10 min of stop-flow ischemia the inhibitory effect of carbachol (10 microM) on stimulation-induced norepinephrine and NPY overflow recovered within 3 min.	Carbachol	98-107	pro-neuropeptide Y	Cavia porcellus	162-165
7889278-19	1994	These results suggest that there is a significant PKC involvement in constriction of bronchioles to carbachol and 5-HT, and that the proportion of the contractile response that can be attributed to PKC is greater in smaller than larger bronchioles.	Carbachol	100-109	protein kinase C, gamma	Rattus norvegicus	50-53
7889307-16	1994	Inclusion of SNP (0.01-1 microM) or 8Br-cyclic GMP (50 microM) in the Ca2+-free medium inhibited the transient residual response to carbachol.	Carbachol	132-141	5'-nucleotidase, cytosolic II	Mus musculus	47-50
7889278-3	1994	In this study we have examined the effects of the specific PKC inhibitors Ro31-8220 and Ro31-7549 and the non-specific inhibitor H7 on carbachol-, 5-hydroxytryptamine (5-HT)- and 4 beta-phorbol dibutyrate (4 beta-PDBu)-induced contractions in large and small bronchioles.	Carbachol	135-144	protein kinase C, gamma	Rattus norvegicus	59-62
7995178-2	1994	An MLCK inhibitor, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine (ML-9), significantly inhibited both the basal pepsinogen secretion and the secretion by carbamylcholine chloride (carbachol) or ionomycin without affecting intracellular free Ca2+ concentration ([Ca2+]i), but not by 12-O-tetradecanoylphorbol-13- acetate (TPA) or forskolin.	Carbachol	170-194	myosin light chain kinase 3	Homo sapiens	3-7
7995178-2	1994	An MLCK inhibitor, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine (ML-9), significantly inhibited both the basal pepsinogen secretion and the secretion by carbamylcholine chloride (carbachol) or ionomycin without affecting intracellular free Ca2+ concentration ([Ca2+]i), but not by 12-O-tetradecanoylphorbol-13- acetate (TPA) or forskolin.	Carbachol	196-205	myosin light chain kinase 3	Homo sapiens	3-7
7995178-3	1994	A PKC inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), significantly reduced the pepsinogen secretion by carbachol or TPA, but not by forskolin or ionomycin, and did not affect the basal secretion and the [Ca2+]i elevated by carbachol or ionomycin.	Carbachol	120-129	proline rich transmembrane protein 2	Homo sapiens	2-5
7995178-3	1994	A PKC inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), significantly reduced the pepsinogen secretion by carbachol or TPA, but not by forskolin or ionomycin, and did not affect the basal secretion and the [Ca2+]i elevated by carbachol or ionomycin.	Carbachol	240-249	proline rich transmembrane protein 2	Homo sapiens	2-5
7889307-17	1994	Inclusion of similar concentrations of SNP or 8Br-cyclic GMP,during Ca2+ re-loading, increased the subsequent residual contraction to carbachol in Ca2+-free medium.7.	Carbachol	134-143	5'-nucleotidase, cytosolic II	Mus musculus	57-60
7895910-6	1994	Exposure to the cholinergic agonist carbachol or the protein tyrosine phosphatase inhibitor orthovandate also induced c-fos transcription.	Carbachol	36-45	Fos proto-oncogene, AP-1 transcription factor subunit	Bos taurus	120-123
7895910-7	1994	Both agents caused repression in c-fos gene activation induced by either IGF-I, carbachol or orthovanadate.	Carbachol	80-89	Fos proto-oncogene, AP-1 transcription factor subunit	Bos taurus	35-38
7969134-6	1994	Point mutations at conserved residues in the Ras-GAP SH3 domain reversed its action, leading to an increase in carbachol-dependent transformation.	Carbachol	111-120	RAS p21 protein activator 1	Mus musculus	45-52
7874280-2	1994	Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels.	Carbachol	35-44	vasoactive intestinal peptide	Homo sapiens	97-100
7874280-2	1994	Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels.	Carbachol	35-44	vasoactive intestinal peptide	Homo sapiens	102-135
7874280-2	1994	Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels.	Carbachol	35-44	pancreatic polypeptide	Homo sapiens	142-164
7874280-2	1994	Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels.	Carbachol	35-44	pancreatic polypeptide	Homo sapiens	166-168
7874280-2	1994	Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels.	Carbachol	46-49	vasoactive intestinal peptide	Homo sapiens	97-100
7874280-2	1994	Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels.	Carbachol	46-49	vasoactive intestinal peptide	Homo sapiens	102-135
7874280-2	1994	Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels.	Carbachol	46-49	pancreatic polypeptide	Homo sapiens	142-164
7874280-2	1994	Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels.	Carbachol	46-49	pancreatic polypeptide	Homo sapiens	166-168
7874280-3	1994	Atropine abolished the stimulatory effect of Cch on glucagon, VIP, and PP release.	Carbachol	45-48	vasoactive intestinal peptide	Homo sapiens	62-65
7969134-7	1994	The inhibitory effect of expression of the Ras-GAP SH3 domain occurs proximal to Ras activation and is selective for the mitogenic pathway activated by carbachol, as cellular transformation by either v-Ras or trkA/nerve growth factor is unaffected.	Carbachol	152-161	RAS p21 protein activator 1	Mus musculus	43-50
7947736-9	1994	RHC-80267 inhibits glucose- and carbachol-induced insulin release from intact islets in a dose-dependent manner that parallels its inhibition of diacylglycerol lipase activity.	Carbachol	32-41	insulin	Homo sapiens	50-57
7977744-2	1994	EGF and TGF-alpha chronically enhanced basal and agonist-stimulated AP accumulation (mean effective concentration 0.6-0.8 nM) but acutely inhibited responses to histamine and carbachol (half-maximal inhibitory concentration approximately 4 nM).	Carbachol	175-184	protransforming growth factor alpha	Oryctolagus cuniculus	8-17
7825914-0	1994	Modulation of carbachol responsiveness by corticosteroid hormones in rat CA1 pyramidal neurons.	Carbachol	14-23	carbonic anhydrase 1	Rattus norvegicus	73-76
7698174-1	1994	In previous studies carbachol-induced stimulation of gastrin release from antral G-cells in primary culture suggested the presence of muscarinic acetylcholine receptors on this cell type.	Carbachol	20-29	gastrin	Oryctolagus cuniculus	53-60
7698174-6	1994	Maximal gastrin release in response to the acetylcholine receptor agonist carbachol (10(-4) M) or the selective muscarinic receptor agonist arecaidine propargyl ester (10(-4) M) was 8.5 +/- 0.4% and 7.6 +/- 0.4% of total cellular content, respectively.	Carbachol	74-83	gastrin	Oryctolagus cuniculus	8-15
7524683-3	1994	Treating acini with carbachol abolished the high affinity state of the CCK receptor and converted approximately 25% of the low affinity receptors to the very low affinity state.	Carbachol	20-29	cholecystokinin	Rattus norvegicus	71-74
7524683-4	1994	Carbachol treatment was particularly useful in establishing the values of Kd for the high and low affinity states for different CCK receptor agonists and antagonists.	Carbachol	0-9	cholecystokinin	Rattus norvegicus	128-131
7524684-6	1994	Specific receptor antagonists could prevent, as well as reverse completely, the translocation of PKC isoforms caused by CCK-8 or carbachol.	Carbachol	129-138	protein kinase C, alpha	Rattus norvegicus	97-100
7943332-10	1994	Increased phosphorylation of the MARCKS and other TPA-regulated proteins suggests that CCK, carbachol, bombesin, and the CCK partial agonist, JMV-180, all activate protein kinase C in intact acini.	Carbachol	92-101	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	33-39
7854066-5	1994	Treatment of the C2C12 muscle cells with carbachol, a cholinergic agonist, induced zif268 gene expression rapidly and transiently.	Carbachol	41-50	early growth response 1	Mus musculus	83-89
7874053-10	1994	We concluded that carbachol and CCK-8 stimulated IF secretion via an increase of intracellular Ca2+ concentration and that secretin did so via a cAMP accumulation.	Carbachol	18-27	cobalamin binding intrinsic factor	Homo sapiens	49-51
7854066-7	1994	Treatment with ryanodine or dantrolene, which block the calcium release channel of the sarcoplasmic reticulum, inhibited the carbachol-induced zif268 response essentially completely.	Carbachol	125-134	early growth response 1	Homo sapiens	143-149
7929563-11	1994	The regulation of bFGF protein content also involves posttranscriptional mechanisms since changes in the levels of individual bFGF isoforms were different depending on whether cells were treated with carbachol or angiotensin II, forskolin, or PMA.	Carbachol	200-209	fibroblast growth factor 2	Homo sapiens	18-22
7859812-8	1994	(3) Removal of PLC-beta 1 from the membranes with 2 M KCl resulted in a significant reduction of the CCh-induced PIP2 hydrolysis, and this effect of the muscarinic agonist was restored when the membrane fraction was supplemented with PLC-beta 1 purified from bovine brain.	Carbachol	101-104	phospholipase C beta 1	Bos taurus	15-25
7859812-8	1994	(3) Removal of PLC-beta 1 from the membranes with 2 M KCl resulted in a significant reduction of the CCh-induced PIP2 hydrolysis, and this effect of the muscarinic agonist was restored when the membrane fraction was supplemented with PLC-beta 1 purified from bovine brain.	Carbachol	101-104	phospholipase C beta 1	Bos taurus	234-244
7929563-11	1994	The regulation of bFGF protein content also involves posttranscriptional mechanisms since changes in the levels of individual bFGF isoforms were different depending on whether cells were treated with carbachol or angiotensin II, forskolin, or PMA.	Carbachol	200-209	fibroblast growth factor 2	Homo sapiens	126-130
7823117-4	1994	Bath application of submicromolar concentrations of carbachol (CCh) produced a gradually developing, long-lasting increase in the CA1 excitatory postsynaptic potential and population spike.	Carbachol	52-61	carbonic anhydrase 1	Rattus norvegicus	130-133
7948036-2	1994	Binding of [125I]CCK-8 to the high affinity state of the receptor was measured as carbachol-inhibitable binding of [125I]CCK-8, whereas binding of [125I]CCK-8 to the low affinity state was measured as carbachol-resistant binding of [125I]CCK-8.	Carbachol	82-91	cholecystokinin	Rattus norvegicus	17-20
7823117-4	1994	Bath application of submicromolar concentrations of carbachol (CCh) produced a gradually developing, long-lasting increase in the CA1 excitatory postsynaptic potential and population spike.	Carbachol	63-66	carbonic anhydrase 1	Rattus norvegicus	130-133
7948036-2	1994	Binding of [125I]CCK-8 to the high affinity state of the receptor was measured as carbachol-inhibitable binding of [125I]CCK-8, whereas binding of [125I]CCK-8 to the low affinity state was measured as carbachol-resistant binding of [125I]CCK-8.	Carbachol	82-91	cholecystokinin	Rattus norvegicus	121-124
7948036-2	1994	Binding of [125I]CCK-8 to the high affinity state of the receptor was measured as carbachol-inhibitable binding of [125I]CCK-8, whereas binding of [125I]CCK-8 to the low affinity state was measured as carbachol-resistant binding of [125I]CCK-8.	Carbachol	82-91	cholecystokinin	Rattus norvegicus	121-124
7948036-2	1994	Binding of [125I]CCK-8 to the high affinity state of the receptor was measured as carbachol-inhibitable binding of [125I]CCK-8, whereas binding of [125I]CCK-8 to the low affinity state was measured as carbachol-resistant binding of [125I]CCK-8.	Carbachol	82-91	cholecystokinin	Rattus norvegicus	121-124
7948036-2	1994	Binding of [125I]CCK-8 to the high affinity state of the receptor was measured as carbachol-inhibitable binding of [125I]CCK-8, whereas binding of [125I]CCK-8 to the low affinity state was measured as carbachol-resistant binding of [125I]CCK-8.	Carbachol	201-210	cholecystokinin	Rattus norvegicus	17-20
7854614-0	1994	Altered modulation by excitatory amino acids of cortical phosphatidylinositol system stimulated by carbachol in rats poisoned by an anti-cholinesterase compound, diisopropyl fluorophosphate.	Carbachol	99-108	butyrylcholinesterase	Rattus norvegicus	137-151
8000501-0	1994	Effects of carbamylcholine chloride on human antral gastrin mRNA levels.	Carbachol	11-35	gastrin	Homo sapiens	52-59
8000501-2	1994	During a-2-h incubation period, carbachol (10(-6)-10(-4) M) decreased gastrin mRNA levels to 71 +/- 8% (10(-6) M), 40 +/- 8% (10(-5) M), and 33 +/- 5% (10(-4) M) of control levels.	Carbachol	32-41	gastrin	Homo sapiens	70-77
8000501-3	1994	Carbachol (10(-5) M) decreased intracellular gastrin (from 1634 +/- 103 to 1272 +/- 126 pg/mg tissue protein), while it increased gastrin release into the medium (from 609 +/- 48 to 918 +/- 68 pg/ml per mg tissue protein).	Carbachol	0-9	gastrin	Homo sapiens	45-52
8000501-3	1994	Carbachol (10(-5) M) decreased intracellular gastrin (from 1634 +/- 103 to 1272 +/- 126 pg/mg tissue protein), while it increased gastrin release into the medium (from 609 +/- 48 to 918 +/- 68 pg/ml per mg tissue protein).	Carbachol	0-9	gastrin	Homo sapiens	130-137
8000501-4	1994	After 6- and 9-h culture, carbachol gradually increased gastrin mRNA levels, by 96 +/- 12% and 126 +/- 23%, respectively.	Carbachol	26-35	gastrin	Homo sapiens	56-63
8000501-7	1994	These findings suggested that carbachol may have a time-related biphasic action on human antral gastrin biosynthesis.	Carbachol	30-39	gastrin	Homo sapiens	96-103
8092325-0	1994	Comparison of fos-like immunoreactivity induced in rat brain by central injection of angiotensin II and carbachol.	Carbachol	104-113	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
7813590-7	1994	In the guinea pig ileum stimulated by carbachol, endothelin-3 induced a transient relaxation followed by sustained relaxation.	Carbachol	38-47	endothelin-3	Cavia porcellus	49-61
8092325-8	1994	The AT1 antagonist prevented carbachol-induced FLI in the MnPO only.	Carbachol	29-38	angiotensin II receptor, type 1a	Rattus norvegicus	4-7
7841454-5	1994	Mepyramine, a histamine H1-receptor antagonist, moderately diminished the carbachol-induced corticosterone response and abolished the rise in hypothalamic histamine levels.	Carbachol	74-83	histamine receptor H 1	Rattus norvegicus	14-35
7812636-7	1994	Repeated periods of illumination at 1.1 x 10(4) lux produced a reversible relaxation of both carbachol and KCl-evoked tone in muscle pretreated with RBS (50 microM).	Carbachol	93-102	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	149-152
7824043-11	1994	We conclude that prolonged incubation with carbachol in rat neonatal ventricular myocytes causes a reduction in cell surface beta 1-Adrenoceptor density.	Carbachol	43-52	adrenoceptor beta 1	Rattus norvegicus	125-144
7935319-6	1994	In addition, cells pretreated with carbachol or thrombin show a normal response to phorbol-12-myristate-13-acetate, suggesting that the enzymatic activity of PLD is not compromised.	Carbachol	35-44	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	158-161
7935319-9	1994	Thrombin and carbachol cause comparable changes in redistribution of both PKC-alpha and PKC-epsilon.	Carbachol	13-22	protein kinase C alpha	Homo sapiens	74-83
7935319-9	1994	Thrombin and carbachol cause comparable changes in redistribution of both PKC-alpha and PKC-epsilon.	Carbachol	13-22	protein kinase C epsilon	Homo sapiens	88-99
7830883-5	1994	Stimulation of the chromaffin cells with the cholinergic agonist carbachol (10(-4) M) increased in parallel the output of neurotrophic factor activity (assayed on chick ciliary ganglionic neurons) as well as two components specifically located in chromaffin granules, chromogranin A and catecholamines.	Carbachol	65-74	chromogranin A	Gallus gallus	268-282
8076696-1	1994	The purpose of this study was to determine the role of protein kinase C (PKC) isozymes in carbachol-induced protein secretion in the lacrimal gland.	Carbachol	90-99	protein kinase C, alpha	Rattus norvegicus	73-76
8063729-5	1994	Carbachol potently induced c-Raf activity as judged by its in vitro phosphorylating activity using MEK as a substrate.	Carbachol	0-9	v-raf-leukemia viral oncogene 1	Mus musculus	27-32
8063729-5	1994	Carbachol potently induced c-Raf activity as judged by its in vitro phosphorylating activity using MEK as a substrate.	Carbachol	0-9	midkine	Mus musculus	99-102
8063729-6	1994	However, induction of Raf-1 kinase activity by carbachol occurred much earlier than changes in its electrophoretic mobility.	Carbachol	47-56	v-raf-leukemia viral oncogene 1	Mus musculus	22-27
8063729-9	1994	However, c-Raf and ERK2 enzymatic activity in response to carbachol was at least 50-80% PKC-independent.	Carbachol	58-67	v-raf-leukemia viral oncogene 1	Mus musculus	9-14
8063729-9	1994	However, c-Raf and ERK2 enzymatic activity in response to carbachol was at least 50-80% PKC-independent.	Carbachol	58-67	mitogen-activated protein kinase 1	Mus musculus	19-23
7945415-5	1994	The PDE IV inhibitors BPX and Ro 20-1724 synergistically increased the relaxant effect of the beta 2-adrenoceptor agonist salbutamol in carbachol-contracted trachea much more strongly than theophylline.	Carbachol	136-145	beta-2 adrenergic receptor	Cavia porcellus	94-113
7800852-2	1994	Carbachol (Cch) stimulated the secretion of CGA and PST from QGP-1N cells derived from a human pancreatic islet cell tumor.	Carbachol	0-9	chromogranin A	Homo sapiens	44-47
7916119-2	1994	In normal dogs, ICV carbachol stimulated marked counterregulatory hormone release, but altered plasma glucose only marginally because the marked increment in glucose production (Ra) was almost matched by the increment of utilization (Rd), even though plasma insulin was unchanged.	Carbachol	20-29	insulin	Canis lupus familiaris	258-265
7800852-0	1994	Production and secretion of chromogranin A and pancreastatin by the human pancreatic carcinoma cell line QGP-1N on stimulation with carbachol.	Carbachol	132-141	chromogranin A	Homo sapiens	28-42
7800852-2	1994	Carbachol (Cch) stimulated the secretion of CGA and PST from QGP-1N cells derived from a human pancreatic islet cell tumor.	Carbachol	11-14	chromogranin A	Homo sapiens	44-47
7800852-6	1994	Stimulation with Cch increased the total amount of PST in the cells and the medium 1.7-fold and decreased the amount of CGA in the cells and medium.	Carbachol	17-20	chromogranin A	Homo sapiens	120-123
7800852-8	1994	Stimulation with Cch resulted in an increase in the intensity of PST-immunoreactive bands and a decrease in those of CGA-immunoreactive bands.	Carbachol	17-20	chromogranin A	Homo sapiens	117-120
7800852-10	1994	These results suggested that (1) the secretion of CGA and PST from QGP-1N cells is regulated mainly through muscarinic receptors coupled with activation of polyphosphoinositide breakdown by a G protein, with intracellular calcium ion and protein kinase C playing a role in the stimulus-secretion coupling and that (2) Cch may induce the secretion of PST and CGA and processing from CGA to PST.	Carbachol	318-321	chromogranin A	Homo sapiens	50-53
7520939-7	1994	IL-1 alpha (500 ng/ml) also inhibited carbachol-stimulated AP accumulation.	Carbachol	38-47	interleukin 1 alpha	Canis lupus familiaris	0-10
7520939-9	1994	TNF-alpha also significantly inhibited histamine/IMX- and carbachol-stimulated AP uptake (P < or = .01).	Carbachol	58-67	tumor necrosis factor	Canis lupus familiaris	0-9
8046453-4	1994	In the present experiments we use extracellular recording and immunocytochemistry for Fos, the protein product of c-fos, to demonstrate the activation of the cells following intracerebroventricular administration of the muscarinic agonist, carbachol.	Carbachol	240-249	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-89
7520939-11	1994	These results show that IL-1 alpha and TNF-alpha inhibit histamine- and carbachol-stimulated isolated parietal cell secretion and that, for IL-1 alpha, this effect does not depend on mucosal prostaglandin synthesis.	Carbachol	72-81	interleukin 1 alpha	Canis lupus familiaris	24-34
7520939-11	1994	These results show that IL-1 alpha and TNF-alpha inhibit histamine- and carbachol-stimulated isolated parietal cell secretion and that, for IL-1 alpha, this effect does not depend on mucosal prostaglandin synthesis.	Carbachol	72-81	tumor necrosis factor	Canis lupus familiaris	39-48
8046453-4	1994	In the present experiments we use extracellular recording and immunocytochemistry for Fos, the protein product of c-fos, to demonstrate the activation of the cells following intracerebroventricular administration of the muscarinic agonist, carbachol.	Carbachol	240-249	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	114-119
8046453-5	1994	Fos expression following carbachol injection was then compared with that induced by a similar number of antidromically evoked action potentials.	Carbachol	25-34	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-3
8026585-3	1994	The concentration-response curve of carbachol for adrenomedullin secretion (EC50 42 microM) was similar to that for catecholamine secretion (EC50 63 microM).	Carbachol	36-45	adrenomedullin	Bos taurus	50-64
7519402-8	1994	Thus GP-2 secretion appears to be modulated by two discrete cellular processes: 1) delivery of prereleased GP-2 within zymogen granules to the ductal lumen by exocytic mechanisms and 2) enzymatic release of GPI-anchored GP-2 from the luminal membranes, a kinetic process that appears to be regulated by secretin- or carbachol-induced secretion of bicarbonate.	Carbachol	316-325	glycoprotein 2	Rattus norvegicus	5-9
7921598-22	1994	The maximal response to ET-1 was less than 20% of that to the cholinoceptor agonist, carbachol.	Carbachol	85-94	endothelin 1	Homo sapiens	24-28
8207426-4	1994	Carbachol-stimulated phosphoinositidase C activity in permeabilized SH-SY5Y cells was also shown to be highly dependent on free Ca2+ concentration (20-100 nM) and suggests that under normal conditions, InsP3 formation is enhanced by increases in cytosolic free Ca2+ concentration that accompany muscarinic receptor activation.	Carbachol	0-9	phospholipase C beta 1	Homo sapiens	21-41
8207426-4	1994	Carbachol-stimulated phosphoinositidase C activity in permeabilized SH-SY5Y cells was also shown to be highly dependent on free Ca2+ concentration (20-100 nM) and suggests that under normal conditions, InsP3 formation is enhanced by increases in cytosolic free Ca2+ concentration that accompany muscarinic receptor activation.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	128-131
8207426-4	1994	Carbachol-stimulated phosphoinositidase C activity in permeabilized SH-SY5Y cells was also shown to be highly dependent on free Ca2+ concentration (20-100 nM) and suggests that under normal conditions, InsP3 formation is enhanced by increases in cytosolic free Ca2+ concentration that accompany muscarinic receptor activation.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	261-264
7516704-1	1994	The secondary structure and effects of two ligands, carbamylcholine and tetracaine, on the secondary structure of affinity-purified nicotinic acetylcholine receptor (nAChR) from Torpedo has been studied using Fourier transform infrared spectroscopy (FTIR).	Carbachol	52-67	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	132-164
7964998-0	1994	Carbachol-induced synchronized rhythmic bursts in CA3 neurons of guinea pig hippocampus in vitro.	Carbachol	0-9	carbonic anhydrase 3	Cavia porcellus	50-53
7964998-2	1994	Carbachol effects on CA3 hippocampal cells were studied in the absence of ionotropic glutamatergic and GABAergic transmission with intracellular and extracellular recordings from guinea pig septohippocampal slices.	Carbachol	0-9	carbonic anhydrase 3	Cavia porcellus	21-24
7516704-1	1994	The secondary structure and effects of two ligands, carbamylcholine and tetracaine, on the secondary structure of affinity-purified nicotinic acetylcholine receptor (nAChR) from Torpedo has been studied using Fourier transform infrared spectroscopy (FTIR).	Carbachol	52-67	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	166-171
7925609-1	1994	In this study, the signal cascade transducing carbachol stimulation into c-fos expression in SH-SY5Y neuroblastoma cells was investigated.	Carbachol	46-55	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
7925609-3	1994	Application of 1,2-dioctanoylglycerol induced c-fos expression and this, as well as carbachol-stimulated c-fos expression, was inhibited by protein kinase C inhibitors.	Carbachol	84-93	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-110
7925609-6	1994	The carbachol-stimulated c-fos expression was potentiated by application of the protein phosphatase inhibitor okadaic acid.	Carbachol	4-13	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-30
7525030-13	1994	This was attributed to an inhibitory G protein (Gi) mechanism, as the muscarinic agonist carbachol, which acts through Gi, produced the same effects as AII.	Carbachol	89-98	angiotensinogen	Rattus norvegicus	152-155
8207320-6	1994	The contractile effect of 100 microM carbachol was antagonized by pretreatment of atropine (1 microM) and 4DAMP (10 nM, antagonist selective for the M1 and M3 receptors) but not by pirenzepine (10 microM, antagonist selective for the M1 receptor), suggesting the involvement of the M3 but not the M1 muscarinic receptor.	Carbachol	37-46	cholinergic receptor muscarinic 1	Homo sapiens	149-168
7523819-2	1994	TRH showed a dose-dependent inhibition of carbachol-stimulated amylase secretion with a maximum of 24% at a concentration of 10(-11) M (p < 0.05).	Carbachol	42-51	thyrotropin releasing hormone	Rattus norvegicus	0-3
7912276-8	1994	High extracellular potassium concentrations or carbachol evoked release of endogenous VIP.	Carbachol	47-56	VIP peptides	Cavia porcellus	86-89
7936115-8	1994	In the presence of the vasopressin antagonist, d(CH2)5(Tyr(Et))DAVP, alone or in combination with phentolamine and propranolol, the pressor response to carbachol was substantially reduced, while the renal and superior mesenteric vasoconstrictor effects were completely abolished; the bradycardia was not significantly affected by this treatment.	Carbachol	152-161	arginine vasopressin	Rattus norvegicus	23-34
7936115-9	1994	These results indicate an important involvement of vasopressin in the cardiovascular responses to carbachol injected into the PVN of untreated animals.	Carbachol	98-107	arginine vasopressin	Rattus norvegicus	51-62
7936115-10	1994	Moreover, in the presence of the vasopressin antagonist the hindquarters vascular bed showed a vasodilatation following PVN injection of carbachol; this effect was reversed to a vasoconstriction following combined i.v.	Carbachol	137-146	arginine vasopressin	Rattus norvegicus	33-44
8203594-5	1994	Carbachol increased 35S-labeled guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) binding maximally 14-fold only when GDP was present by an excess of > 100 times [35S]GTP gamma S, while R-PIA increased binding only 2-fold.	Carbachol	0-9	RPTOR independent companion of MTOR complex 2	Homo sapiens	191-194
8156901-6	1994	The cholinergic agonist carbachol stimulated GLP-1 secretion in a concentration-dependent manner, maximal release was observed at 1 mM carbachol (228% of the control value).	Carbachol	24-33	glucagon	Mus musculus	45-50
8156901-6	1994	The cholinergic agonist carbachol stimulated GLP-1 secretion in a concentration-dependent manner, maximal release was observed at 1 mM carbachol (228% of the control value).	Carbachol	135-144	glucagon	Mus musculus	45-50
8182471-1	1994	We have investigated the regulation of phosphorylation of the nicotinic ACh receptor (nAChR) in rat myotubes by the agonist carbamylcholine.	Carbachol	124-139	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	62-84
8182471-1	1994	We have investigated the regulation of phosphorylation of the nicotinic ACh receptor (nAChR) in rat myotubes by the agonist carbamylcholine.	Carbachol	124-139	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	86-91
8182471-4	1994	Pretreatment of myotubes with d-tubocurare, but not with atropine, inhibited carbamylcholine-stimulated phosphorylation of the nAChR.	Carbachol	77-92	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	127-132
8182471-5	1994	Preincubation with open-channel blockers of the nAChR also inhibited phosphorylation of the nAChR induced by carbamylcholine.	Carbachol	109-124	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	48-53
8182471-5	1994	Preincubation with open-channel blockers of the nAChR also inhibited phosphorylation of the nAChR induced by carbamylcholine.	Carbachol	109-124	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	92-97
8182471-6	1994	Depletion of extracellular calcium from myotube cultures prevented carbamylcholine-stimulated increases in nAChR phosphorylation whereas application of a calcium ionophore mimicked the effect of carbamylcholine on nAChR phosphorylation.	Carbachol	67-82	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	107-112
8182471-6	1994	Depletion of extracellular calcium from myotube cultures prevented carbamylcholine-stimulated increases in nAChR phosphorylation whereas application of a calcium ionophore mimicked the effect of carbamylcholine on nAChR phosphorylation.	Carbachol	67-82	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	214-219
8182471-6	1994	Depletion of extracellular calcium from myotube cultures prevented carbamylcholine-stimulated increases in nAChR phosphorylation whereas application of a calcium ionophore mimicked the effect of carbamylcholine on nAChR phosphorylation.	Carbachol	195-210	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	214-219
8182471-8	1994	Carbamylcholine increased nAChR phosphorylation to the same extent and with the same time course and subunit specificity as that induced by phorbol esters.	Carbachol	0-15	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	26-31
7916769-1	1994	Acute pretreatment (30 min) of primary cultures of cerebellar granule cells with TPA (10 nM) resulted in a decrease in carbachol-and glutamate-stimulated phosphoinositide hydrolysis, but not in basal levels of PI hydrolysis.	Carbachol	119-128	plasminogen activator, tissue type	Homo sapiens	81-84
7916769-5	1994	TPA treatment results in a statistically significant decrease in glutamate-stimulated PI hydrolysis, and a slight reduction of carbachol-stimulated PI hydrolysis when compared to temporally matched controls.	Carbachol	127-136	plasminogen activator, tissue type	Homo sapiens	0-3
8197564-8	1994	Incubation experiments revealed a simultaneous in vitro release of VIP and PP with a significant increase by either carbachol or phorbol myristate acetate but not by theophylline or caerulein.	Carbachol	116-125	vasoactive intestinal peptide	Homo sapiens	67-70
8197564-8	1994	Incubation experiments revealed a simultaneous in vitro release of VIP and PP with a significant increase by either carbachol or phorbol myristate acetate but not by theophylline or caerulein.	Carbachol	116-125	pancreatic polypeptide	Homo sapiens	75-77
8197564-9	1994	Atropine completely abolished the stimulatory effects of carbachol on VIP and PP release.	Carbachol	57-66	vasoactive intestinal peptide	Homo sapiens	70-73
8197564-9	1994	Atropine completely abolished the stimulatory effects of carbachol on VIP and PP release.	Carbachol	57-66	pancreatic polypeptide	Homo sapiens	78-80
8203594-3	1994	Addition of (-)-N6-(2-phenylisopropyl)adenosine (R-PIA) in the presence of carbachol did not further reduce force of contraction.	Carbachol	75-84	RPTOR independent companion of MTOR complex 2	Homo sapiens	51-54
8182531-10	1994	Taken together, these results suggest that the coupling of m1 receptors to a putative phospholipase A2 that is positively regulated by protein kinase C and by calcium is necessary for the carbachol-evoked release of AA.	Carbachol	188-197	phospholipase A2, group IB, pancreas	Mus musculus	86-102
7913969-9	1994	Effects of the NO-releasing agent molsidomine (SIN-1) on CCh-induced changes in ICa(L) were also investigated.	Carbachol	57-60	MAPK associated protein 1	Homo sapiens	47-52
8137762-5	1994	PTHrP mRNA expression was weak in the physiological fasting and feeding states, but was markedly increased by pyloric ligation and carbachol stimulation.	Carbachol	131-140	parathyroid hormone-like hormone	Rattus norvegicus	0-5
8045358-7	1994	However, carbachol treatment did elicit STC release as revealed by the lowering of JinCa2+.	Carbachol	9-18	stanniocalcin	Oncorhynchus mykiss	40-43
7515904-12	1994	This effect was prevented by N(G)-nitro-L-arginine (L-NNA), which also inhibited VIP-stimulated secretion of amylase; however, L-NNA had no effect on amylase secretion stimulated by carbachol.	Carbachol	182-191	vasoactive intestinal peptide	Homo sapiens	81-84
7512633-3	1994	Carbachol, which activates both nicotinic and muscarinic receptors, produces 12-19-fold increases in PNMT mRNA and a 22-fold increase in epinephrine release.	Carbachol	0-9	phenylethanolamine N-methyltransferase	Bos taurus	101-105
7512633-4	1994	Selective nicotinic and muscarinic antagonists (hexamethonium and atropine) each partially reduce carbachol-stimulated increases in PNMT mRNA while a combination of both eliminates > 90% of the carbachol response, thus indicating that separable nicotinic and muscarinic components contribute to the cholinergic increase in PNMT mRNA.	Carbachol	98-107	phenylethanolamine N-methyltransferase	Bos taurus	132-136
7512633-4	1994	Selective nicotinic and muscarinic antagonists (hexamethonium and atropine) each partially reduce carbachol-stimulated increases in PNMT mRNA while a combination of both eliminates > 90% of the carbachol response, thus indicating that separable nicotinic and muscarinic components contribute to the cholinergic increase in PNMT mRNA.	Carbachol	98-107	phenylethanolamine N-methyltransferase	Bos taurus	326-330
7513126-3	1994	Carbachol also dose-dependently increased HDC activity (EC50 7.08 +/- 0.32 nM), and its effect was reversed by selective muscarinic-receptor antagonists with the following order of potency: pirenzepine (IC50 15.1 +/- 1.2 nM) > para-fluoro-hexahydro-siladifenidol (IC50 0.316 +/- 0.02 microM) > 11-2[(2-[(diethyl-amino)-methyl]-1-piperidinyl)acetyl]-5,11-dihydro-6H- pyrido[2,3-b][1,4]benzodiazepine-6-one (IC50 28.5 +/- 1.1 microM).	Carbachol	0-9	histidine decarboxylase	Oryctolagus cuniculus	42-45
7517089-4	1994	Different from CCK-8, EGF reduced amylase release at both submaximal (< or = 1 microM) and supramaximal (> 1 microM) carbachol concentrations.	Carbachol	123-132	epidermal growth factor like 1	Rattus norvegicus	22-25
7517089-5	1994	Moreover, EGF (17 nM) inhibited bombesin-, carbachol-, and CCK-8-induced 1,4,5-IP3-production at five seconds after beginning of the incubation by 81 +/- 19%, 65 +/- 15%, and 60 +/- 12%, respectively.	Carbachol	43-52	epidermal growth factor like 1	Rattus norvegicus	10-13
7912604-5	1994	The inhibitory effect of somatostatin on secretin-induced pepsinogen secretion was abolished by pretreatment with pertussis toxin, but inhibition of forskolin-, carbachol- and cholecystokinin octapeptide-induced pepsinogen secretion was not.	Carbachol	161-170	somatostatin	Homo sapiens	25-37
7509377-8	1994	Secretory activity was elevated by both forms of c-src in response to either nicotine or carbachol (which activate the nicotinic and the nicotinic/muscarinic receptors, respectively).	Carbachol	89-98	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-54
8172620-0	1994	Role of calcium in carbachol- and neurotensin-induced mucin exocytosis in a human colonic goblet cell line and cross-talk with the cyclic AMP pathway.	Carbachol	19-28	LOC100508689	Homo sapiens	54-59
8172620-2	1994	Carbachol, a cholinergic agonist, induced an initial concentration-dependent [Ca2+]i peak increasing from 129 +/- 3 nM (basal [Ca2+]i) to 608 +/- 101 nM at 1 x 10(-4) M carbachol with an ED50 of 7 microM, and this was followed by a lower-level plateau.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	78-81
8172620-2	1994	Carbachol, a cholinergic agonist, induced an initial concentration-dependent [Ca2+]i peak increasing from 129 +/- 3 nM (basal [Ca2+]i) to 608 +/- 101 nM at 1 x 10(-4) M carbachol with an ED50 of 7 microM, and this was followed by a lower-level plateau.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	127-130
8172620-2	1994	Carbachol, a cholinergic agonist, induced an initial concentration-dependent [Ca2+]i peak increasing from 129 +/- 3 nM (basal [Ca2+]i) to 608 +/- 101 nM at 1 x 10(-4) M carbachol with an ED50 of 7 microM, and this was followed by a lower-level plateau.	Carbachol	169-178	carbonic anhydrase 2	Homo sapiens	78-81
8172620-8	1994	Carbachol-induced mucin exocytosis was concentration-dependent with an ED50 of 15 microM, and was inhibited by 35% upon removal of extracellular Ca2+.	Carbachol	0-9	LOC100508689	Homo sapiens	18-23
8172620-8	1994	Carbachol-induced mucin exocytosis was concentration-dependent with an ED50 of 15 microM, and was inhibited by 35% upon removal of extracellular Ca2+.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	145-148
8172620-10	1994	Together our results suggest that while the mucin secretory response to carbachol depends on both the release of Ca2+ from intracellular stores and a Ca2+ influx from external medium, the secretory response to neurotensin is based solely on intracellular Ca2+ mobilization.	Carbachol	72-81	LOC100508689	Homo sapiens	44-49
8172620-10	1994	Together our results suggest that while the mucin secretory response to carbachol depends on both the release of Ca2+ from intracellular stores and a Ca2+ influx from external medium, the secretory response to neurotensin is based solely on intracellular Ca2+ mobilization.	Carbachol	72-81	carbonic anhydrase 2	Homo sapiens	113-116
8172620-10	1994	Together our results suggest that while the mucin secretory response to carbachol depends on both the release of Ca2+ from intracellular stores and a Ca2+ influx from external medium, the secretory response to neurotensin is based solely on intracellular Ca2+ mobilization.	Carbachol	72-81	carbonic anhydrase 2	Homo sapiens	150-153
8172620-10	1994	Together our results suggest that while the mucin secretory response to carbachol depends on both the release of Ca2+ from intracellular stores and a Ca2+ influx from external medium, the secretory response to neurotensin is based solely on intracellular Ca2+ mobilization.	Carbachol	72-81	carbonic anhydrase 2	Homo sapiens	150-153
8172620-11	1994	Finally, evaluation of the cross-talk between the cyclic AMP pathway stimulated by vasoactive intestinal peptide (VIP) and the Ca2+ pathway stimulated by neurotensin or carbachol led to the conclusion that the potentiated secretory response elicited by the combined action of carbachol and VIP requires extracellular Ca2+.	Carbachol	169-178	carbonic anhydrase 2	Homo sapiens	127-130
8141291-3	1994	Enprostil (10(-10)-10(-6) M) inhibited gastrin secretion in response to bombesin, carbachol, and forskolin, the latter a receptor-independent activator of adenylate cyclase.	Carbachol	82-91	gastrin	Canis lupus familiaris	39-46
8004403-19	1994	The response to carbachol appeared to be mediated by an M3-muscarinic receptor (apparent Kd for pirenzepine 0.09 microM).	Carbachol	16-25	cholinergic receptor muscarinic 3	Homo sapiens	56-78
8175604-4	1994	Airway responsiveness was expressed as the cumulative provocative dose of carbachol that increased sRL to 4 cmH2O/s [PD4, in breath units (BU; 1 BU = 1 breath of 1% carbachol solution)].	Carbachol	74-83	sarcalumenin	Rattus norvegicus	99-102
7509388-4	1994	Carbachol increased cyclic GMP formation in the mixture of cells in a time- and concentration-dependent manner, with a half-maximal response occurring in the nanomolar range.	Carbachol	0-9	5'-nucleotidase, cytosolic II	Mus musculus	27-30
7513126-4	1994	Moreover, gastrin and carbachol were able to modify slightly but significantly both the Michaelis constant (Km) and the maximal velocity (Vmax) of HDC in the same way (18-20% reduction of the Km and 25-30% increase of the Vmax).	Carbachol	22-31	histidine decarboxylase	Oryctolagus cuniculus	147-150
8297348-9	1994	The specific PKC inhibitor RO 31-7459 (10 microM) was found to inhibit K(+)- and carbachol-evoked release by 27% and 68% respectively.	Carbachol	81-90	protein kinase C alpha	Homo sapiens	13-16
7509439-7	1994	The increase in substance P binding induced by carbamylcholine was blocked by the nicotinic antagonists alpha-bungarotoxin and d-tubocurarine but was not affected by the muscarinic antagonist atropine.	Carbachol	47-62	tachykinin precursor 1	Homo sapiens	16-27
7907526-3	1994	Here, we report that the alpha 2 antagonist idazoxan (IZ) enhances REM-like sleep states in the cat when microinfused into the rostral part of the mPRF at sites where carbachol produced a marked increase in REM.	Carbachol	167-176	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	147-151
8297348-11	1994	These data suggest that PKC-alpha and/or PKC-epsilon play an essential role in the regulation of PMA-enhanced K(+)- and carbachol-evoked NA release in SH-SY5Y cells.	Carbachol	120-129	protein kinase C alpha	Homo sapiens	24-33
8297348-11	1994	These data suggest that PKC-alpha and/or PKC-epsilon play an essential role in the regulation of PMA-enhanced K(+)- and carbachol-evoked NA release in SH-SY5Y cells.	Carbachol	120-129	protein kinase C epsilon	Homo sapiens	41-52
7508198-5	1994	Preincubation of carbachol-treated muscle strips with calphostin C restored the ability of VIP to stimulate L-[3H]citrulline production and the ability of L-NNA to inhibit VIP-induced relaxation.	Carbachol	17-26	VIP peptides	Oryctolagus cuniculus	91-94
7508198-5	1994	Preincubation of carbachol-treated muscle strips with calphostin C restored the ability of VIP to stimulate L-[3H]citrulline production and the ability of L-NNA to inhibit VIP-induced relaxation.	Carbachol	17-26	VIP peptides	Oryctolagus cuniculus	172-175
7914493-10	1994	However, acetylcholinesterase does not hydrolyse carbachol and therefore it is necessary to postulate a different post-synaptic mechanism to explain the lesion-induced increases in the sensitivities of individual neurones to carbachol and to acetylcholine; interpretation of experimental findings should take these two mechanisms into account.	Carbachol	225-234	acetylcholinesterase	Rattus norvegicus	9-29
8201782-5	1994	Activation of the KCa channel was suppressed when the intracellular production of cAMP was suppressed by preincubation with carbachol (10(-6) M).	Carbachol	124-133	casein kappa	Homo sapiens	18-21
8014894-12	1994	Treatment (24-48 h) of VMH neurones with antisense phosphothio-oligodeoxynucleotides to the G alpha 11 G-protein subunit (10 microM) significantly diminished the carbachol-induced depression of IK.	Carbachol	162-171	G protein subunit alpha 11	Rattus norvegicus	92-102
8134614-2	1993	Carbachol stimulated secretion of neurotensin concentration-dependently in the range of 10(-6) - 10(-4) M. The neurotensin secretion stimulated with 10(-5) M carbachol was completely inhibited by atropine at 10(-5) M. Phorbol ester and calcium ionophore (A23187) stimulated secretion of neurotensin.	Carbachol	0-9	neurotensin	Homo sapiens	34-45
7997057-10	1994	Interestingly, neuropeptides such as neurotensin, cholecystokinin and VIP can potentiate carbachol-stimulated phosphoinositide hydrolysis in frontal cortex of both young and aged rats.	Carbachol	89-98	vasoactive intestinal peptide	Rattus norvegicus	70-73
18475595-3	1994	Furthermore, interferon gamma increased the affinity of carbachol for the cholinoceptors and did not change its maximum effect.	Carbachol	56-65	interferon gamma	Rattus norvegicus	13-29
7535425-7	1994	VIP and galanin alone had no effect on cell length, but each caused a dose-dependent inhibition of carbachol-induced contraction and both had an EC50 of 3-7 nM.	Carbachol	99-108	VIP peptides	Cavia porcellus	0-3
8262183-4	1993	Phosphorylation of the m3-muscarinic receptor was agonist dependent, reaching a maximum after 10 min exposure to carbachol (1 mM) and was completely blocked by atropine (10 microM).	Carbachol	113-122	cholinergic receptor muscarinic 3	Homo sapiens	23-45
8974323-5	1994	Stimulation with CCh also induced expression of the immediate-early gene c-fos in these cells.	Carbachol	17-20	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
7816994-7	1994	The authors report evidence of non-specific bronchial hyper-reactivity (HRB) to Carbachol in a patient effected with benign cutaneous mastocytosis with secondary elevation of the total serum IGE.	Carbachol	80-89	ArfGAP with FG repeats 1	Homo sapiens	72-75
8134614-2	1993	Carbachol stimulated secretion of neurotensin concentration-dependently in the range of 10(-6) - 10(-4) M. The neurotensin secretion stimulated with 10(-5) M carbachol was completely inhibited by atropine at 10(-5) M. Phorbol ester and calcium ionophore (A23187) stimulated secretion of neurotensin.	Carbachol	0-9	neurotensin	Homo sapiens	111-122
8134614-2	1993	Carbachol stimulated secretion of neurotensin concentration-dependently in the range of 10(-6) - 10(-4) M. The neurotensin secretion stimulated with 10(-5) M carbachol was completely inhibited by atropine at 10(-5) M. Phorbol ester and calcium ionophore (A23187) stimulated secretion of neurotensin.	Carbachol	0-9	neurotensin	Homo sapiens	111-122
8134614-2	1993	Carbachol stimulated secretion of neurotensin concentration-dependently in the range of 10(-6) - 10(-4) M. The neurotensin secretion stimulated with 10(-5) M carbachol was completely inhibited by atropine at 10(-5) M. Phorbol ester and calcium ionophore (A23187) stimulated secretion of neurotensin.	Carbachol	158-167	neurotensin	Homo sapiens	34-45
8134614-2	1993	Carbachol stimulated secretion of neurotensin concentration-dependently in the range of 10(-6) - 10(-4) M. The neurotensin secretion stimulated with 10(-5) M carbachol was completely inhibited by atropine at 10(-5) M. Phorbol ester and calcium ionophore (A23187) stimulated secretion of neurotensin.	Carbachol	158-167	neurotensin	Homo sapiens	111-122
8134614-2	1993	Carbachol stimulated secretion of neurotensin concentration-dependently in the range of 10(-6) - 10(-4) M. The neurotensin secretion stimulated with 10(-5) M carbachol was completely inhibited by atropine at 10(-5) M. Phorbol ester and calcium ionophore (A23187) stimulated secretion of neurotensin.	Carbachol	158-167	neurotensin	Homo sapiens	111-122
8134614-5	1993	Neurotensin released into culture medium through stimulation with carbachol coeluted with neurotensin 1-13 on a gel-chromatography.	Carbachol	66-75	neurotensin	Homo sapiens	0-11
8134614-5	1993	Neurotensin released into culture medium through stimulation with carbachol coeluted with neurotensin 1-13 on a gel-chromatography.	Carbachol	66-75	neurotensin	Homo sapiens	90-101
8250938-1	1993	The phospholipase A2 (PLA2) inhibitors quinacrine, manoalide and scalaradial inhibit the carbachol-stimulated secretion of the amyloid precursor protein (APP) from cells transfected with the human m1 muscarinic receptor.	Carbachol	89-98	phospholipase A2 group IB	Homo sapiens	4-20
8243834-7	1993	However, anti-G alpha q completely inhibited the Ca(2+)-mobilizing effect of carbachol, but not of glucose, within 5 min.	Carbachol	77-86	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	14-23
8250938-1	1993	The phospholipase A2 (PLA2) inhibitors quinacrine, manoalide and scalaradial inhibit the carbachol-stimulated secretion of the amyloid precursor protein (APP) from cells transfected with the human m1 muscarinic receptor.	Carbachol	89-98	phospholipase A2 group IB	Homo sapiens	22-26
8250938-1	1993	The phospholipase A2 (PLA2) inhibitors quinacrine, manoalide and scalaradial inhibit the carbachol-stimulated secretion of the amyloid precursor protein (APP) from cells transfected with the human m1 muscarinic receptor.	Carbachol	89-98	amyloid beta precursor protein	Homo sapiens	127-152
7510053-1	1993	Experiments were performed to investigate the mechanism underlying the potentiation of N-methyl-D-aspartate (NMDA) responses by carbachol (CCh) in the CA1 region of rat hippocampal slices.	Carbachol	128-137	carbonic anhydrase 1	Rattus norvegicus	151-154
7510053-1	1993	Experiments were performed to investigate the mechanism underlying the potentiation of N-methyl-D-aspartate (NMDA) responses by carbachol (CCh) in the CA1 region of rat hippocampal slices.	Carbachol	139-142	carbonic anhydrase 1	Rattus norvegicus	151-154
7510053-6	1993	These data suggest that low concentrations of CCh can acutely potentiate NMDA responses in the hippocampus by a Ca(2+)-sensitive process that is probably independent of both the activation of PKC and the release of Ca2+ from intracellular stores.	Carbachol	46-49	carbonic anhydrase 2	Rattus norvegicus	215-218
8226807-4	1993	Inhibition of A beta secretion could also be effected by direct stimulation of m1 muscarinic acetylcholine receptors with carbachol.	Carbachol	122-131	amyloid beta precursor protein	Homo sapiens	14-20
8218298-2	1993	Insulin secretagogues, such as glucose and the muscarinic agonist carbachol, stimulate arachidonic acid accumulation, although the mechanisms involved are controversial: carbachol is believed to stimulate phospholipase A2, while glucose-induced arachidonic acid release is the result of diacylglycerol hydrolysis [Konrad, R. J., et al.	Carbachol	66-75	insulin	Homo sapiens	0-7
8218298-2	1993	Insulin secretagogues, such as glucose and the muscarinic agonist carbachol, stimulate arachidonic acid accumulation, although the mechanisms involved are controversial: carbachol is believed to stimulate phospholipase A2, while glucose-induced arachidonic acid release is the result of diacylglycerol hydrolysis [Konrad, R. J., et al.	Carbachol	66-75	phospholipase A2 group IB	Homo sapiens	205-221
8218298-2	1993	Insulin secretagogues, such as glucose and the muscarinic agonist carbachol, stimulate arachidonic acid accumulation, although the mechanisms involved are controversial: carbachol is believed to stimulate phospholipase A2, while glucose-induced arachidonic acid release is the result of diacylglycerol hydrolysis [Konrad, R. J., et al.	Carbachol	170-179	insulin	Homo sapiens	0-7
8218298-2	1993	Insulin secretagogues, such as glucose and the muscarinic agonist carbachol, stimulate arachidonic acid accumulation, although the mechanisms involved are controversial: carbachol is believed to stimulate phospholipase A2, while glucose-induced arachidonic acid release is the result of diacylglycerol hydrolysis [Konrad, R. J., et al.	Carbachol	170-179	phospholipase A2 group IB	Homo sapiens	205-221
8218298-9	1993	The combination of glucose and carbachol transiently activated Ca(2+)-dependent (but not Ca(2+)-independent) phospholipase A2 activity at 10 min, which corresponded to the peak of arachidonic acid release.	Carbachol	31-40	phospholipase A2 group IB	Homo sapiens	109-125
8293296-0	1993	Modulation of carbachol responsiveness in rat CA1 pyramidal neurons by corticosteroid hormones.	Carbachol	14-23	carbonic anhydrase 1	Rattus norvegicus	46-49
8293296-2	1993	In this in vitro study we investigated if occupation of MRs or GRs affects the responsiveness of CA1 pyramidal neurons to the cholinergic analogue carbachol.	Carbachol	147-156	carbonic anhydrase 1	Rattus norvegicus	97-100
7511424-2	1993	Acetylcholine and carbachol as well as nicotine decreased basal and hCG-induced T secretion.	Carbachol	18-27	hypertrichosis 2 (generalised, congenital)	Homo sapiens	68-71
8245971-2	1993	In the present study we show that carbachol (CCh) and Leu-Enkephalin act synergistically with vasoactive intestinal peptide (VIP) and corticotropin-releasing hormone (CRH), but not with l-isoproterenol, in increasing cyclic AMP formation.	Carbachol	34-43	vasoactive intestinal peptide	Rattus norvegicus	125-128
8245971-2	1993	In the present study we show that carbachol (CCh) and Leu-Enkephalin act synergistically with vasoactive intestinal peptide (VIP) and corticotropin-releasing hormone (CRH), but not with l-isoproterenol, in increasing cyclic AMP formation.	Carbachol	34-43	corticotropin releasing hormone	Rattus norvegicus	134-165
8245971-2	1993	In the present study we show that carbachol (CCh) and Leu-Enkephalin act synergistically with vasoactive intestinal peptide (VIP) and corticotropin-releasing hormone (CRH), but not with l-isoproterenol, in increasing cyclic AMP formation.	Carbachol	34-43	corticotropin releasing hormone	Rattus norvegicus	167-170
8245971-2	1993	In the present study we show that carbachol (CCh) and Leu-Enkephalin act synergistically with vasoactive intestinal peptide (VIP) and corticotropin-releasing hormone (CRH), but not with l-isoproterenol, in increasing cyclic AMP formation.	Carbachol	45-48	vasoactive intestinal peptide	Rattus norvegicus	125-128
8245971-2	1993	In the present study we show that carbachol (CCh) and Leu-Enkephalin act synergistically with vasoactive intestinal peptide (VIP) and corticotropin-releasing hormone (CRH), but not with l-isoproterenol, in increasing cyclic AMP formation.	Carbachol	45-48	corticotropin releasing hormone	Rattus norvegicus	134-165
8245971-2	1993	In the present study we show that carbachol (CCh) and Leu-Enkephalin act synergistically with vasoactive intestinal peptide (VIP) and corticotropin-releasing hormone (CRH), but not with l-isoproterenol, in increasing cyclic AMP formation.	Carbachol	45-48	corticotropin releasing hormone	Rattus norvegicus	167-170
8245971-6	1993	Substitution of the stable GTP analog guanosine 5"-O-(3"-thiotriphosphate) for GTP allows the CRH stimulation, but abolishes the CCh enhancement of both basal and CRH-stimulated enzyme activities.	Carbachol	129-132	corticotropin releasing hormone	Rattus norvegicus	163-166
8234284-4	1993	When injected into the AV3V region, the cholinergic drug carbachol induces natriuresis and the release of ANP.	Carbachol	57-66	natriuretic peptide A	Rattus norvegicus	106-109
8238525-6	1993	Stimulation of Caco-2 cell monolayers with phorbol myristate acetate or with the combination of carbachol and monolein was also associated with phosphorylation of the MARCKS protein, an endogenous substrate of PKC.	Carbachol	96-105	myristoylated alanine rich protein kinase C substrate	Homo sapiens	167-173
7693670-7	1993	Simultaneous incubation of carbachol with CCK or TPA increased the relative affinity of [3H]NMS binding, and the competitive inhibition curves showed a single class of carbachol binding site.	Carbachol	27-36	cholecystokinin	Homo sapiens	42-45
8246917-6	1993	The carbachol-elicited loss of m2- and m3-mAChR mRNA was blocked by their corresponding receptor subtype-specific antagonists, AF-DX 116 (m2-selective) and 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) (m3-selective), and was concurrent with an increase in c-fos mRNA levels.	Carbachol	4-13	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	268-273
7902747-5	1993	Under the same conditions, accumulations of radiolabelled IP1 and IP2 were reduced and those of GPI and IP3 unchanged in carbachol-treated cultures.	Carbachol	121-130	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	58-61
7693670-7	1993	Simultaneous incubation of carbachol with CCK or TPA increased the relative affinity of [3H]NMS binding, and the competitive inhibition curves showed a single class of carbachol binding site.	Carbachol	168-177	cholecystokinin	Homo sapiens	42-45
7693670-11	1993	Incubation of acini with carbachol resulted in a decrease of [3H] NMS binding sites, and the addition of CCK or TPA caused an inhibition of the carbachol-induced disappearance of [3H]NMS binding sites.	Carbachol	144-153	cholecystokinin	Homo sapiens	105-108
8375509-3	1993	Both GTP gamma S and carbachol increase the Ca2+ sensitivity of myosin light chain kinase phosphorylation as well as light chain phosphorylation.	Carbachol	21-30	myosin light chain kinase	Homo sapiens	64-89
8415767-0	1993	Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture.	Carbachol	87-96	aldo-keto reductase family 1 member B	Homo sapiens	20-36
7693670-12	1993	Finally, studies that examined the biological response of the acinar cells showed that biphasic amylase release in response to carbachol was completely suppressed by 10 nM CCK for entire range of carbachol.	Carbachol	127-136	cholecystokinin	Homo sapiens	172-175
7693670-12	1993	Finally, studies that examined the biological response of the acinar cells showed that biphasic amylase release in response to carbachol was completely suppressed by 10 nM CCK for entire range of carbachol.	Carbachol	196-205	cholecystokinin	Homo sapiens	172-175
7693670-13	1993	Taken together, these results suggest that the effect of CCK on carbachol-induced sequestration is important for the alteration of the apparent affinity of carbachol binding sites and the biological response of acinar cells to carbachol.	Carbachol	64-73	cholecystokinin	Homo sapiens	57-60
7693670-13	1993	Taken together, these results suggest that the effect of CCK on carbachol-induced sequestration is important for the alteration of the apparent affinity of carbachol binding sites and the biological response of acinar cells to carbachol.	Carbachol	156-165	cholecystokinin	Homo sapiens	57-60
7693670-13	1993	Taken together, these results suggest that the effect of CCK on carbachol-induced sequestration is important for the alteration of the apparent affinity of carbachol binding sites and the biological response of acinar cells to carbachol.	Carbachol	156-165	cholecystokinin	Homo sapiens	57-60
8143240-4	1993	However, in rings precontracted to a similar tone by endothelin-1, the relaxation elicited by carbachol was reduced in the vein but remained unchanged in the artery.	Carbachol	94-103	endothelin-1	Oryctolagus cuniculus	53-65
8281323-2	1993	When Na+ currents were blocked with tetrodotoxin and K+ conductances known to be sensitive to suppression by muscarinic agonists were blocked by 2 mM Ba2+, CA1 cells were depolarized by carbachol (3-10 microM) with an attendant conductance increase, whereas prior to Ba2+ the agonist produced a decrease or no change in conductance.	Carbachol	186-195	carbonic anhydrase 1	Homo sapiens	156-159
8268454-4	1993	At the highest dose of anti-IgE used, contraction reached 10.3 and 9.6% of the maximal carbachol contraction, respectively, as compared with 30.3% for solvent.	Carbachol	87-96	immunoglobulin heavy constant epsilon	Homo sapiens	28-31
8402579-2	1993	Carbachol and serum which act as growth factors for these cells induced a rapid, transient increase of intracellular Ca2+ concentration without a sustained increase.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	117-120
8237421-6	1993	Pre-incubation with vasoactive intestinal polypeptide (VIP), which coexists with acetylcholine in the parasympathetic neurons innervating the submandibular gland, increased the carbachol-induced tritium overflow significantly.	Carbachol	177-186	vasoactive intestinal peptide	Rattus norvegicus	20-53
8237421-6	1993	Pre-incubation with vasoactive intestinal polypeptide (VIP), which coexists with acetylcholine in the parasympathetic neurons innervating the submandibular gland, increased the carbachol-induced tritium overflow significantly.	Carbachol	177-186	vasoactive intestinal peptide	Rattus norvegicus	55-58
8237421-7	1993	The effect of VIP could be imitated by the adenylyl cyclase stimulator forskolin, which increased the carbachol-stimulated tritium efflux in a dose dependent manner.	Carbachol	102-111	vasoactive intestinal peptide	Rattus norvegicus	14-17
8255727-3	1993	CCh-evoked current oscillations were followed very closely by oscillations in intracellular free Ca2+ estimated from the Indo-1 signal, and were abolished by inclusion of EGTA in the pipette solution.	Carbachol	0-3	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	97-100
8255727-7	1993	The present results are consistent with the hypothesis that CCh-evoked cationic current is gated by activation of a G protein and is steeply dependent on [Ca2+]i, fluctuations in the release of Ca2+ from stores during carbachol"s action produce oscillations in [Ca2+]i which cause similar oscillations in the cationic current.	Carbachol	60-63	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	155-158
8255727-7	1993	The present results are consistent with the hypothesis that CCh-evoked cationic current is gated by activation of a G protein and is steeply dependent on [Ca2+]i, fluctuations in the release of Ca2+ from stores during carbachol"s action produce oscillations in [Ca2+]i which cause similar oscillations in the cationic current.	Carbachol	60-63	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	194-197
8255727-7	1993	The present results are consistent with the hypothesis that CCh-evoked cationic current is gated by activation of a G protein and is steeply dependent on [Ca2+]i, fluctuations in the release of Ca2+ from stores during carbachol"s action produce oscillations in [Ca2+]i which cause similar oscillations in the cationic current.	Carbachol	60-63	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	194-197
8255727-7	1993	The present results are consistent with the hypothesis that CCh-evoked cationic current is gated by activation of a G protein and is steeply dependent on [Ca2+]i, fluctuations in the release of Ca2+ from stores during carbachol"s action produce oscillations in [Ca2+]i which cause similar oscillations in the cationic current.	Carbachol	218-227	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	155-158
8255727-7	1993	The present results are consistent with the hypothesis that CCh-evoked cationic current is gated by activation of a G protein and is steeply dependent on [Ca2+]i, fluctuations in the release of Ca2+ from stores during carbachol"s action produce oscillations in [Ca2+]i which cause similar oscillations in the cationic current.	Carbachol	218-227	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	194-197
8255727-7	1993	The present results are consistent with the hypothesis that CCh-evoked cationic current is gated by activation of a G protein and is steeply dependent on [Ca2+]i, fluctuations in the release of Ca2+ from stores during carbachol"s action produce oscillations in [Ca2+]i which cause similar oscillations in the cationic current.	Carbachol	218-227	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	194-197
8104089-0	1993	Bidirectional modulation of long-term potentiation by carbachol via M1 and M2 muscarinic receptors in guinea pig hippocampal mossy fiber-CA3 synapses.	Carbachol	54-63	carbonic anhydrase 3	Cavia porcellus	137-140
8104089-4	1993	On the contrary, a high concentration (10 microM) of carbachol decreased the pre-tetanic amplitude of fEPSP, however, the magnitude of LTP was significantly larger than that in control slices in which pre-tetanic amplitude of fEPSP was reduced to the level of carbachol-treated slices by reducing the intensity of stimulation or extracellular Ca2+ concentration.	Carbachol	53-62	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	343-346
8368310-6	1993	[4Cl-D-Phe6,Leu17]VIP (3.3 mg/kg), an antagonist to VIP, reduced basal, VIP-stimulated, and carbachol-stimulated HCO3- secretion.	Carbachol	92-101	VIP peptides	Cavia porcellus	18-21
8368310-6	1993	[4Cl-D-Phe6,Leu17]VIP (3.3 mg/kg), an antagonist to VIP, reduced basal, VIP-stimulated, and carbachol-stimulated HCO3- secretion.	Carbachol	92-101	VIP peptides	Cavia porcellus	52-55
8368310-6	1993	[4Cl-D-Phe6,Leu17]VIP (3.3 mg/kg), an antagonist to VIP, reduced basal, VIP-stimulated, and carbachol-stimulated HCO3- secretion.	Carbachol	92-101	VIP peptides	Cavia porcellus	52-55
8106077-6	1993	Somatostatin did not inhibit carbachol- or CCK-8-induced [Ca2+]i increase, but did inhibit carbachol- and CCK-8-induced pepsinogen secretion by 30 and 50%, respectively.	Carbachol	91-100	somatostatin	Homo sapiens	0-12
7693285-5	1993	ET-1 was a potent and effective contractile agonist in human bronchus, possessing similar potency and efficacy to leukotriene D4 (LTD4); EC50 (-log M): ET-1 = 7.76 +/- 0.09, n = 7; LTD4 = 8.46 +/- 0.53, n = 7; P > 0.2; maximum response (% 10 microM pre-carbachol): ET-1 = 103.8 +/- 17.4, n = 7; LTD4 = 95.5 +/- 9.3, n = 7; P > 0.6.	Carbachol	256-265	endothelin 1	Homo sapiens	0-4
8101558-4	1993	Carbachol increased NO release in a concentration-dependent manner, with half-maximal stimulation at 173 microM (compared to 96 microM for direct activation of cyclic GMP formation).	Carbachol	0-9	5'-nucleotidase, cytosolic II	Homo sapiens	167-170
8102378-6	1993	SST (1 microM) and CLON (10 microM) reduced the Isc response to the muscarinic agonist, carbachol, by 60-70%; inhibition was reversed in pertussis toxin-treated cells.	Carbachol	88-97	somatostatin	Homo sapiens	0-3
8414920-7	1993	VIP (9 x 10(-9) mol/l) depolarized Vbl from -72 +/- 3 mV to -53 +/- 3 mV (n = 20) and CCH (10(-5) mol/l) from -62 +/- 3 to -35 +/- 4 mV (n = 10).	Carbachol	86-89	vasoactive intestinal peptide	Rattus norvegicus	0-3
8393663-1	1993	Treatment of CHO cells stably expressing the human M1 muscarinic acetylcholine (HM1) receptor with the cholinergic agonist carbachol results in a reduction in cellular levels of Gq alpha/G11 alpha.	Carbachol	123-132	cholinergic receptor muscarinic 1	Homo sapiens	80-83
8503569-7	1993	There was a correlation between the percentage suppression of GM-CSF staining by inhaled corticosteroids and the percentage increase in FEV1 (r = 0.61, p < 0.05) and percentage decrease in carbachol responsiveness (r = 0.80, p < 0.01).	Carbachol	192-201	colony stimulating factor 2	Homo sapiens	62-68
7692123-3	1993	The contractile force induced by 10(-6) M ET-1 was approximately 30% of that induced by 3 x 10(-5) M carbachol in detrusor muscle strips, approximately 40% of that induced by 10(-4) M norepinephrine in spermatic cord muscle strips and almost equal to that induced by 10(-5) M phenylephrine in prostatic adenoma muscle strips.	Carbachol	101-110	endothelin 1	Homo sapiens	42-46
8233038-4	1993	The effects of L-AP3 was in contrast with those of a typical receptor antagonist, atropine; atropine inhibited carbachol-induced phosphoinositide hydrolysis, but the levels of [3H]PIs were not affected.	Carbachol	111-120	leucine aminopeptidase 3	Rattus norvegicus	15-20
8347135-6	1993	Carbamylcholine induced a transient decrease in the gastric PAF level of normal rats, which was not associated with gastric erosion formation.	Carbachol	0-15	PCNA clamp associated factor	Rattus norvegicus	60-63
8102036-3	1993	Feeding or the cholinergic agonist carbachol increased plasma PP levels in conscious mice (+74 +/- 18 pg/ml vs. fasted mice and +141 +/- 17 pg/ml vs. control, respectively).	Carbachol	35-44	pancreatic polypeptide	Mus musculus	62-64
8102933-4	1993	In tracheal strips precontracted (60-70% of the maximum) with carbachol, ET-1 (1-100 nM) evoked slowly developing concentration-dependent relaxations.	Carbachol	62-71	endothelin-1	Cavia porcellus	73-77
8407282-7	1993	On the contrary, Lyt 2.2+ cells were only able to respond to carbachol stimulus increasing cGMP levels and inositol phosphate formation while L3T4+ cells were unable to do it.	Carbachol	61-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	17-20
8276492-0	1993	Endothelin-1 and carbachol: differences in contractile effects and myosin phosphorylation in lamb tracheal smooth muscle.	Carbachol	17-26	myosin heavy chain 14	Homo sapiens	67-73
8276492-3	1993	Equimolar concentrations (10(-6)M) of endothelin 1 and carbachol elicit rapidly rising isometric tension which is maintained indefinitely in a steady state when fibres are stimulated with carbachol.	Carbachol	188-197	endothelin 1	Homo sapiens	38-50
8103217-0	1993	PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: additive augmentation of CCK/carbachol-induced enzyme release.	Carbachol	138-147	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-5
8103217-0	1993	PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: additive augmentation of CCK/carbachol-induced enzyme release.	Carbachol	138-147	vasoactive intestinal peptide	Rattus norvegicus	10-13
8103217-0	1993	PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: additive augmentation of CCK/carbachol-induced enzyme release.	Carbachol	138-147	vasoactive intestinal peptide	Rattus norvegicus	86-89
8103217-0	1993	PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: additive augmentation of CCK/carbachol-induced enzyme release.	Carbachol	138-147	adenylate cyclase activating polypeptide 1	Rattus norvegicus	90-95
8103217-8	1993	Co-incubation of PACAP(1-27) or VIP with cholecystokinin-8 or carbachol revealed additive effects on enzyme secretion.	Carbachol	62-71	adenylate cyclase activating polypeptide 1	Rattus norvegicus	17-22
8103217-8	1993	Co-incubation of PACAP(1-27) or VIP with cholecystokinin-8 or carbachol revealed additive effects on enzyme secretion.	Carbachol	62-71	vasoactive intestinal peptide	Rattus norvegicus	32-35
7688904-6	1993	or carbachol (100 microM, infusion) reduced ACh release and reduced the stimulation of ACh release by GAL with a magnitude corresponding to that of oxotremorine or carbachol alone.	Carbachol	3-12	galanin and GMAP prepropeptide	Rattus norvegicus	102-105
7688904-6	1993	or carbachol (100 microM, infusion) reduced ACh release and reduced the stimulation of ACh release by GAL with a magnitude corresponding to that of oxotremorine or carbachol alone.	Carbachol	164-173	galanin and GMAP prepropeptide	Rattus norvegicus	102-105
8499491-4	1993	Treatment of the cells with 10(-6) M bradykinin exhausts calcium release such that the successive treatment of the cells with norepinephrine, carbachol, or serotonin results in no secondary response.	Carbachol	142-151	kininogen 1	Homo sapiens	37-47
8499491-5	1993	In contrast, bradykinin treatment of the cells following exposure to norepinephrine, carbachol, or serotonin caused a secondary increase in calcium release.	Carbachol	85-94	kininogen 1	Homo sapiens	13-23
7684070-4	1993	Substance P increased the apparent affinity of the cholinergic agonists carbamylcholine and acetylcholine at equilibrium.	Carbachol	72-87	tachykinin precursor 1	Homo sapiens	0-11
8501533-0	1993	C-fos expression in the pons and medulla of the cat during carbachol-induced active sleep.	Carbachol	59-68	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	0-5
8501533-4	1993	On the other hand, the mean number of c-fos-expressing neurons found in the masseter, facial, and hypoglossal nuclei was lower in carbachol-injected than in control cats.	Carbachol	130-139	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	38-43
8501533-6	1993	The specific sites in which there were greater numbers of c-fos-expressing neurons during active sleep-carbachol are discussed in relation to the state of active sleep, as well as the functional role that these sites play in generating the various physiological patterns of activity that occur during this state.	Carbachol	103-112	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	58-63
7684070-7	1993	Substance P appeared to increase the rate of carbamylcholine-induced desensitization; however, the data are also consistent with an allosteric mechanism that does not involve the desensitized state.	Carbachol	45-60	tachykinin precursor 1	Homo sapiens	0-11
8482444-9	1993	CONCLUSIONS: Intestinal macrophages produce a novel mucin secretagogue, which is as potent as carbachol for stimulating mucin secretion from colonic epithelial cells.	Carbachol	94-103	LOC100508689	Homo sapiens	52-57
8510018-7	1993	In contrast to the contractile effect on longitudinal smooth muscle, ET-1 produced a potent concentration-dependent inhibition of both the spontaneous phasic activity and carbachol-stimulated activity of the circular smooth muscle.	Carbachol	171-180	endothelin 1	Rattus norvegicus	69-73
8510018-10	1993	ET-1 also inhibited carbachol-induced increases in the phasic activity of circular smooth muscle with a similar potency.	Carbachol	20-29	endothelin 1	Rattus norvegicus	0-4
8389541-2	1993	Stimulation of [3H]-inositol labeled pancreatic minilobules by buffer, bombesin, neuromedin B or carbachol in presence of 10 mM lithium, followed by separation of inositol phosphates, yielded the following results for cyclic inositol monophosphate (cIP) [DPM/mg protein; Mean +/- SEM (n)]: control [21 +/- 6, (9)]; bombesin [145 +/- 24, (12)]; neuromedin B (99 +/- 22 (9)] and carbachol [512 +/- 60, (12)].	Carbachol	377-386	neuromedin B	Rattus norvegicus	81-93
8099469-8	1993	These studies support the conclusion that antibodies to the somatostatin complementary peptide demonstrate properties similar to those of somatostatin in that they inhibit carbachol-stimulated aminopyrine uptake and 125I-somatostatin binding.	Carbachol	172-181	somatostatin	Canis lupus familiaris	60-72
8099469-8	1993	These studies support the conclusion that antibodies to the somatostatin complementary peptide demonstrate properties similar to those of somatostatin in that they inhibit carbachol-stimulated aminopyrine uptake and 125I-somatostatin binding.	Carbachol	172-181	somatostatin	Canis lupus familiaris	138-150
8099469-8	1993	These studies support the conclusion that antibodies to the somatostatin complementary peptide demonstrate properties similar to those of somatostatin in that they inhibit carbachol-stimulated aminopyrine uptake and 125I-somatostatin binding.	Carbachol	172-181	somatostatin	Canis lupus familiaris	138-150
8097876-4	1993	Carbachol stimulated secretion of PST and SMT and intracellular Ca2+ mobilization in the range of 10(-6)-10(-4) M. The secretion and Ca2+ mobilization were inhibited by atropine, a muscarinic receptor antagonist.	Carbachol	0-9	somatostatin	Homo sapiens	42-45
8482444-9	1993	CONCLUSIONS: Intestinal macrophages produce a novel mucin secretagogue, which is as potent as carbachol for stimulating mucin secretion from colonic epithelial cells.	Carbachol	94-103	LOC100508689	Homo sapiens	120-125
8335576-11	1993	These observations suggest that cooling induces from the epithelium the release of a cytochrome P-450-derived eicosanoid that potentiates contractions of the underlying airway smooth muscle to carbachol.	Carbachol	193-202	Cytochrome P450 1A1	Canis lupus familiaris	85-101
8462791-9	1993	Pretreatment of isolated chief cells with motilin and erythromycin induced a reversible, dose- and time-dependent desensitization of the pepsinogen secretion stimulated by carbachol and cholecystokinin but not that stimulated by secretin, vasoactive intestinal peptide, or prostaglandin E2.	Carbachol	172-181	motilin	Homo sapiens	42-49
8320719-5	1993	Stimulation with carbachol shifted the distribution of cells to a more stellate morphology within 24 hr and later (after 48 hr) reduced the PKC substrate 80K/MARCKS by 22 +/- 7%.	Carbachol	17-26	myristoylated alanine rich protein kinase C substrate	Mus musculus	158-164
8479283-8	1993	Stimulation of mAChRs by the cholinergic agonist carbachol resulted in a pronounced increase in the intensity of 36G9 immunoreactivity, which may suggest that the mAChRs are functionally linked to the colocalized PKC gamma.	Carbachol	49-58	protein kinase C, gamma	Rattus norvegicus	213-222
7680902-2	1993	In the present study we treated pancreatic acini with carbachol to induce a complete loss of high-affinity CCK receptors and then examined the action of CCK-8 on inositol trisphosphate IP3(1,4,5), cytosolic calcium and amylase secretion in an effort to confirm and extend our previous hypothesis.	Carbachol	54-63	cholecystokinin	Homo sapiens	107-110
8455027-5	1993	The addition of carbachol to [3H]cytidine-prelabeled cells elicited a four- to fivefold increase in the accumulation of labeled CDP-DAG.	Carbachol	16-25	cut like homeobox 1	Homo sapiens	128-131
8455027-7	1993	This result was in sharp contrast to findings in rat brain slices, in which carbachol-stimulated formation of [3H]CDP-DAG was potentiated approximately 10-fold by Li+ and substantially reduced by coincubation with inositol.	Carbachol	76-85	cut like homeobox 1	Homo sapiens	114-117
8455027-8	1993	The formation of [3H]CDP-DAG in labeled SK-N-SH cells by carbachol was both concentration and time dependent.	Carbachol	57-66	cut like homeobox 1	Homo sapiens	21-24
8455027-8	1993	The formation of [3H]CDP-DAG in labeled SK-N-SH cells by carbachol was both concentration and time dependent.	Carbachol	57-66	hedgehog acyltransferase	Homo sapiens	40-44
7680902-3	1993	We found that first incubating pancreatic acini with 10 mM carbachol decreased binding of 125I-CCK-8 measured during a second incubation by causing a complete loss of high-affinity CCK receptors with no change in the low-affinity CCK receptors.	Carbachol	59-68	cholecystokinin	Homo sapiens	95-98
7681672-0	1993	Substance P inhibits catecholamine biosynthesis stimulated by carbamylcholine in cultured adrenal chromaffin cells.	Carbachol	62-77	tachykinin precursor 1	Bos taurus	0-11
8452524-1	1993	In an inositol-depleted 1321 N1 astrocytoma cell line, propranolol at 0.5 mM concentration and carbachol in the presence of Li+ induce a large increase (30-60-fold) in the amount of CMP-phosphatidate, the lipid substrate of PtdIns synthase.	Carbachol	95-104	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	224-239
8452524-6	1993	There were two coincident peaks of carbachol-stimulated [3H]CMP-phosphatidate and PtdIns synthase activity, respectively.	Carbachol	35-44	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	82-97
8452524-8	1993	The later peak, containing both carbachol-stimulated [3H]CMP-phosphatidate and PtdIns synthase activity, has a distribution in the gradient that is similar to NADPH-cytochrome c reductase activity, an endoplasmic-reticulum marker.	Carbachol	32-41	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	79-94
8097916-5	1993	In addition, the increase in somatostatin secretion induced by incubation with veratridine (10(-4) M) or carbachol (10(-4) M) for 90 min was significantly reduced by the addition of caprylic acid, but somatostatin release stimulated by 5.6 x 10(-2) M KCl was not affected.	Carbachol	105-114	somatostatin	Rattus norvegicus	29-41
8097916-5	1993	In addition, the increase in somatostatin secretion induced by incubation with veratridine (10(-4) M) or carbachol (10(-4) M) for 90 min was significantly reduced by the addition of caprylic acid, but somatostatin release stimulated by 5.6 x 10(-2) M KCl was not affected.	Carbachol	105-114	somatostatin	Rattus norvegicus	201-213
7680902-3	1993	We found that first incubating pancreatic acini with 10 mM carbachol decreased binding of 125I-CCK-8 measured during a second incubation by causing a complete loss of high-affinity CCK receptors with no change in the low-affinity CCK receptors.	Carbachol	59-68	cholecystokinin	Homo sapiens	181-184
7680902-3	1993	We found that first incubating pancreatic acini with 10 mM carbachol decreased binding of 125I-CCK-8 measured during a second incubation by causing a complete loss of high-affinity CCK receptors with no change in the low-affinity CCK receptors.	Carbachol	59-68	cholecystokinin	Homo sapiens	181-184
8483799-4	1993	Carbachol dose-dependently stimulated the release of motilin from its producing cell.	Carbachol	0-9	motilin	Canis lupus familiaris	53-60
8095065-0	1993	Pairing the cholinergic agonist carbachol with patterned Schaffer collateral stimulation initiates protein synthesis in hippocampal CA1 pyramidal cell dendrites via a muscarinic, NMDA-dependent mechanism.	Carbachol	32-41	carbonic anhydrase 1	Homo sapiens	132-135
8460100-6	1993	Carbachol (0.1 mM) increased the release of IAPP-LI at the lower glucose concentrations: 8.1 +/- 0.9, 8.7 +/- 0.6, and 11.7 +/- 1.8 fmol/islet/60 m in at 2, 7, and 20 mM glucose.	Carbachol	0-9	islet amyloid polypeptide	Rattus norvegicus	44-48
8383442-3	1993	Pretreatment of rabbit parietal cells with 10(-7) M rat TGF-alpha resulted in inhibition of both histamine- and carbachol-stimulated [14C]-aminopyrine (AP) accumulation.	Carbachol	112-121	transforming growth factor alpha	Rattus norvegicus	56-65
8464401-5	1993	In distal circular colon maximal inotropic response (10.1 +/- 2.1% of a maximal response to carbachol 10(-5) M) was found at PYY 10(-8) M; (ED50 3.1 +/- 1.2 x 10(-9) M).	Carbachol	92-101	peptide YY	Oryctolagus cuniculus	125-128
8381292-5	1993	After preconstriction with carbamylcholine, the TNF-alpha- and IL-1 beta-pretreated tissues produced a significant reduction in the maximal relaxation induced by isoproterenol, whereas the IL-2 pretreatment had no effect.	Carbachol	27-42	tumor necrosis factor	Cavia porcellus	48-57
8381292-5	1993	After preconstriction with carbamylcholine, the TNF-alpha- and IL-1 beta-pretreated tissues produced a significant reduction in the maximal relaxation induced by isoproterenol, whereas the IL-2 pretreatment had no effect.	Carbachol	27-42	interleukin-1 beta	Cavia porcellus	63-72
8382264-1	1993	Administration of carbachol, noradrenaline, and bradykinin induced Egr-1 mRNA expression within 1 h in mouse neuroblastoma x rat glioma hybrid NG108-15 cells.	Carbachol	18-27	early growth response 1	Mus musculus	67-72
8382264-2	1993	With specific receptor antagonists, the Egr-1 inductions by carbachol and noradrenaline were shown to be mediated via cholinergic muscarinic and alpha 2-adrenergic receptors, respectively.	Carbachol	60-69	early growth response 1	Mus musculus	40-45
8382264-5	1993	On the other hand, bradykinin consistently had an additive effect on Egr-1 induction, irrespective of the time of its addition, suggesting that the signal pathways for Egr-1 induction by carbachol or noradrenaline and by bradykinin are different.	Carbachol	187-196	early growth response 1	Mus musculus	168-173
8382264-6	1993	Treatment of cells with pertussis toxin or cholera toxin strongly inhibited Egr-1 induction by carbachol or noradrenaline but only partially inhibited the induction by bradykinin.	Carbachol	95-104	early growth response 1	Mus musculus	76-81
8093872-1	1993	We have examined the release of gastrin and somatostatin from the isolated perfused stomach of rats of three different age groups (4 months, 12 months, and 24 months old) in response to bombesin and carbachol.	Carbachol	199-208	gastrin	Rattus norvegicus	32-39
8093872-1	1993	We have examined the release of gastrin and somatostatin from the isolated perfused stomach of rats of three different age groups (4 months, 12 months, and 24 months old) in response to bombesin and carbachol.	Carbachol	199-208	somatostatin	Rattus norvegicus	44-56
8093872-4	1993	Bombesin (10(-10) and 10(-9) M) and carbachol (10(-8) and 10(-7) M) stimulated gastrin release in each age group.	Carbachol	36-45	gastrin	Rattus norvegicus	79-86
8093872-5	1993	The integrated release of gastrin in response to bombesin (10(-10) and 10(-9) M) or carbachol (10(-8) M) did not differ among the three age groups, although integrated gastrin release in response to carbachol (10(-7) M) decreased in 24-month-old rats.	Carbachol	84-93	gastrin	Rattus norvegicus	26-33
8093872-5	1993	The integrated release of gastrin in response to bombesin (10(-10) and 10(-9) M) or carbachol (10(-8) M) did not differ among the three age groups, although integrated gastrin release in response to carbachol (10(-7) M) decreased in 24-month-old rats.	Carbachol	199-208	gastrin	Rattus norvegicus	168-175
8093872-7	1993	Carbachol inhibited release of somatostatin in each age group.	Carbachol	0-9	somatostatin	Rattus norvegicus	31-43
8386783-3	1993	The purpose of this study was firstly to evaluate the interaction of cAMP-dependent agents (vasoactive intestinal polypeptide (VIP), norepinephrine (NE), and forskolin (FK)) on carbachol (Ca2+)-initiated motility and secondly to determine if a neural component of motility modulation existed by testing if the effect of cAMP-dependent agents was reversed by tetrodotoxin-induced neural blockade.	Carbachol	177-186	VIP peptides	Oryctolagus cuniculus	92-125
8386783-3	1993	The purpose of this study was firstly to evaluate the interaction of cAMP-dependent agents (vasoactive intestinal polypeptide (VIP), norepinephrine (NE), and forskolin (FK)) on carbachol (Ca2+)-initiated motility and secondly to determine if a neural component of motility modulation existed by testing if the effect of cAMP-dependent agents was reversed by tetrodotoxin-induced neural blockade.	Carbachol	177-186	VIP peptides	Oryctolagus cuniculus	127-130
8386783-6	1993	VIP, NE, and FK each caused a concentration-dependent inhibition of carbachol-stimulated phasic contractions.	Carbachol	68-77	VIP peptides	Oryctolagus cuniculus	0-3
8395431-1	1993	Smooth muscle cells isolated from the gastric muscle layers of the guinea pig were used to determine whether neurotensin can inhibit the contractile response produced by 10(-6) M carbachol by exerting a direct action on muscle cells.	Carbachol	179-188	neurotensin/neuromedin N	Cavia porcellus	109-120
8093872-8	1993	Compared with 4-month-old rats, the inhibition of somatostatin release by carbachol was less in 24-month-old rats at 10(-8) and 10(-7) M, and less in 12-month-old rats at 10(-7) M. The decreased basal gastrin secretion and well-preserved gastrin response were further confirmed in conscious aged rats tested by means of oral gavage with 10% peptone.	Carbachol	74-83	somatostatin	Rattus norvegicus	50-62
8093872-8	1993	Compared with 4-month-old rats, the inhibition of somatostatin release by carbachol was less in 24-month-old rats at 10(-8) and 10(-7) M, and less in 12-month-old rats at 10(-7) M. The decreased basal gastrin secretion and well-preserved gastrin response were further confirmed in conscious aged rats tested by means of oral gavage with 10% peptone.	Carbachol	74-83	gastrin	Rattus norvegicus	201-208
8093872-8	1993	Compared with 4-month-old rats, the inhibition of somatostatin release by carbachol was less in 24-month-old rats at 10(-8) and 10(-7) M, and less in 12-month-old rats at 10(-7) M. The decreased basal gastrin secretion and well-preserved gastrin response were further confirmed in conscious aged rats tested by means of oral gavage with 10% peptone.	Carbachol	74-83	gastrin	Rattus norvegicus	238-245
8109333-1	1993	In intact smooth muscle strips from chicken gizzard, carbachol elicited brief, phasic contractions which were associated with a very rapid, transient phosphorylation of the 20 kDa myosin light chains.	Carbachol	53-62	myosin, heavy chain 15	Gallus gallus	180-186
8426908-6	1993	Rat TGF alpha inhibited carbachol stimulation throughout an agonist dose response.	Carbachol	24-33	transforming growth factor alpha	Rattus norvegicus	4-13
8426908-7	1993	Human TGF alpha was only effective in inhibiting carbachol if incubations were performed in the presence of air rather than 100% O2.	Carbachol	49-58	transforming growth factor alpha	Homo sapiens	6-15
8426908-8	1993	In air incubation, all three of the TGF alpha fragments inhibited carbachol stimulation but, in contrast to the effects on histamine, the peptides all were virtually equipotent with the native molecule.	Carbachol	66-75	transforming growth factor alpha	Homo sapiens	36-45
8426908-10	1993	The results suggest that there are pharmacological differences in the response of isolated parietal cells to TGF alpha-mediated inhibition of histamine and carbachol.	Carbachol	156-165	transforming growth factor alpha	Homo sapiens	109-118
8249680-11	1993	In a carbachol-induced stress model, insulin is not required for a putatively neural regulation of an increase in systemic glucose uptake but a "permissive" effect of insulin is essential.	Carbachol	5-14	insulin	Homo sapiens	37-44
8249680-11	1993	In a carbachol-induced stress model, insulin is not required for a putatively neural regulation of an increase in systemic glucose uptake but a "permissive" effect of insulin is essential.	Carbachol	5-14	insulin	Homo sapiens	167-174
7748314-6	1993	Carbachol (1 mM) induced a maximal c-fos mRNA response after 40 minutes in SH-SY5Y cells, an effect that could be mimicked through protein kinase C stimulation by phorbol esters.	Carbachol	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-40
7684284-1	1993	In the cat, gastric lipase secretion was equally but weakly stimulated by pentagastrin, a major stimulant of acid secretion, and by carbamylcholine, a major stimulant of pepsin secretion.	Carbachol	132-147	lipase F, gastric type	Homo sapiens	12-26
8395431-3	1993	Neurotensin inhibited the contractile response produced by carbachol in a dose-dependent manner, with an IC50 value of 5 nM.	Carbachol	59-68	neurotensin/neuromedin N	Cavia porcellus	0-11
8510560-6	1993	Addition of GTP gamma S plus carbachol to sphincter muscle membranes prelabeled with [3H]inositol or 3H-arachidonic acid resulted in the formation of lysophosphatidylinositol and the liberation of arachidonic acid, thus suggesting the involvement of phospholipase A2.	Carbachol	29-38	LOC104974671	Bos taurus	250-266
8510072-7	1993	The pharmacological response of functional mAChRs, determined as accumulation of inositol phosphates induced by carbachol, is greater in the medium containing IGF-I and insulin than that cultured in 0.1% BSA.	Carbachol	112-121	insulin like growth factor 1	Canis lupus familiaris	159-164
1334091-1	1992	The histamine H3 receptor agonist (R)alpha-methylhistamine (MeHA) inhibited, in a nanomolar range, basal and carbachol-stimulated inositol phosphate formation in the human gastric tumoral cell line HGT1-clone 6.	Carbachol	109-118	histamine receptor H3	Homo sapiens	4-25
1334091-1	1992	The histamine H3 receptor agonist (R)alpha-methylhistamine (MeHA) inhibited, in a nanomolar range, basal and carbachol-stimulated inositol phosphate formation in the human gastric tumoral cell line HGT1-clone 6.	Carbachol	109-118	solute carrier family 25 member 16	Homo sapiens	198-202
1301240-6	1992	(ii) The cholinesterase-resistant agonist carbachol (10(-9)-2.5 x 10(-6) M) elicited a 2- to 3-fold greater negative chronotropic response in the aged compared with adult hearts.	Carbachol	42-51	butyrylcholinesterase	Rattus norvegicus	9-23
1359019-2	1992	Continuous exposure of the cells to carbachol or the nicotinic receptor agonist 1,1-dimethyl-4-phenylpiperazinium (DMPP) produces a time- and concentration-dependent increase in TH enzyme activity, whereas muscarine has no effect.	Carbachol	36-45	tyrosine hydroxylase	Bos taurus	178-180
1493543-1	1992	Thymopoietin, a polypeptide hormone isolated from thymus and involved in immune function, potently inhibited [125I]alpha-bungarotoxin binding to neonatal muscle cells in culture (IC50 = 3.8 nM) and blocked carbachol-stimulated 22Na uptake with an IC50 of 1.9 +/- 0.2 nM and 23 +/- 7 nM at a half-maximal and maximal concentration of carbachol, respectively.	Carbachol	206-215	thymopoietin	Homo sapiens	0-12
1493543-1	1992	Thymopoietin, a polypeptide hormone isolated from thymus and involved in immune function, potently inhibited [125I]alpha-bungarotoxin binding to neonatal muscle cells in culture (IC50 = 3.8 nM) and blocked carbachol-stimulated 22Na uptake with an IC50 of 1.9 +/- 0.2 nM and 23 +/- 7 nM at a half-maximal and maximal concentration of carbachol, respectively.	Carbachol	333-342	thymopoietin	Homo sapiens	0-12
1493543-4	1992	Thymopoietin did not appreciably alter myotube morphology on its own; however, it prevented the effects of nicotine and carbachol on muscle cell morphology at concentrations (1-10 nM) which corresponded well to those with which thymopoietin interacted at the receptor.	Carbachol	120-129	thymopoietin	Homo sapiens	0-12
1333428-6	1992	A 7.8% +/- 1.7% increase in mucin above basal levels after 24 hours was observed with a solid-phase immunoassay in control wells, whereas histamine, gastrin, and carbamylcholine increased total mucin by 14% +/- 0.7%, 17% +/- 4.3%, and 20.4% +/- 4%, respectively (all P < 0.01), and PGE2 had no significant effect.	Carbachol	162-177	mucin	Canis lupus familiaris	194-199
1333428-8	1992	The acid secretagogues histamine, gastrin, and carbamylcholine stimulated mucin synthesis and PC release.	Carbachol	47-62	mucin	Canis lupus familiaris	74-79
1288495-0	1992	The cholinergic agonist carbachol reduces intracellular beta-amyloid precursor protein in PC 12 and C6 cells.	Carbachol	24-33	amyloid beta precursor protein	Rattus norvegicus	56-86
1475305-4	1992	We now report the effects of carbachol microinjected into CA1, the DG, or the ventral subiculum (VS) on acoustic startle and PPI.	Carbachol	29-38	carbonic anhydrase 1	Rattus norvegicus	58-61
1475305-5	1992	Carbachol infusion into CA1 or the DG depressed startle.	Carbachol	0-9	carbonic anhydrase 1	Rattus norvegicus	24-27
1475305-6	1992	Carbachol infusion decreased PPI with a regional rank-order potency CA1 > DG > VS. CA1 infusions more potently depressed the startle reflex.	Carbachol	0-9	carbonic anhydrase 1	Rattus norvegicus	68-71
1331066-3	1992	Carbachol-mediated activation of the Hm1 receptor in the 39M1-81 clone, which is not a mitogenic signal, produced a similarly rapid although greater activation of PLD.	Carbachol	0-9	cholinergic receptor muscarinic 1	Homo sapiens	37-40
1279984-4	1992	The inhibitory effect of neurotensin during CCH stimulation was blocked concentration dependently in the presence of the K(+)-channel blocker apamin.	Carbachol	44-47	neurotensin	Rattus norvegicus	25-36
1279984-8	1992	After depletion of internal Ca2+ stores by repetitive stimulation with CCH and caffeine in Ca(2+)-free buffer, reintroduction of external Ca2+ restored neurotensin inhibition of the contraction induced by CCH.	Carbachol	205-208	neurotensin	Rattus norvegicus	152-163
1443219-1	1992	In conscious, unrestrained rats, the intracerebroventricular injection of the cholinergic agonist, carbachol, or angiotensin II resulted in the transient stimulation of vasopressin secretion, elevation of mean arterial blood pressure, and reduction of heart rate.	Carbachol	99-108	arginine vasopressin	Rattus norvegicus	169-180
1443219-2	1992	After the injection of carbachol (25 ng) into a lateral cerebral ventricle, the plasma vasopressin concentration in male rats was increased to twice that of female rats in each phase of the estrous cycle; mean arterial blood pressure was elevated more in males than females, whereas heart rate fell to the same extent in both sexes.	Carbachol	23-32	arginine vasopressin	Rattus norvegicus	87-98
1282072-13	1992	The NK1-selective antagonist (+/-)-CP-96,345 also inhibited responses of the rat bladder and guinea-pig ileum to substance P methyl ester; however, in the rat bladder at 1 microM, this antagonist reversibly inhibited responses both to the NK2-selective agonist [beta-Ala8]-NKA(4-10) and to the muscarinic agonist carbachol (P < or = 0.01), thus showing evidence of some non-selective depressant actions.	Carbachol	313-322	tachykinin receptor 1	Homo sapiens	4-7
1306243-3	1992	IL-2 enhanced carbachol (Carb)- and KCl-induced contraction, and attenuated isoproterenol (Iso)-induced relaxation.	Carbachol	14-23	interleukin-2	Cavia porcellus	0-4
1306243-3	1992	IL-2 enhanced carbachol (Carb)- and KCl-induced contraction, and attenuated isoproterenol (Iso)-induced relaxation.	Carbachol	25-29	interleukin-2	Cavia porcellus	0-4
1331066-3	1992	Carbachol-mediated activation of the Hm1 receptor in the 39M1-81 clone, which is not a mitogenic signal, produced a similarly rapid although greater activation of PLD.	Carbachol	0-9	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	163-166
1331066-5	1992	In each case, the stimulation of PLD correlated closely with the ability to stimulate inositol phospholipid breakdown and was entirely dependent on the activation of protein kinase C. Moreover, the ability of both thrombin and carbachol to stimulate PLD was found to be rapidly desensitized, with a similar time course of desensitization (t1/2 desensitization, 90 s).	Carbachol	227-236	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	33-36
1331066-5	1992	In each case, the stimulation of PLD correlated closely with the ability to stimulate inositol phospholipid breakdown and was entirely dependent on the activation of protein kinase C. Moreover, the ability of both thrombin and carbachol to stimulate PLD was found to be rapidly desensitized, with a similar time course of desensitization (t1/2 desensitization, 90 s).	Carbachol	227-236	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	250-253
1331066-7	1992	In this regard, in addition to stimulation of PLD, thrombin and carbachol were both able to stimulate the activity of a phosphocholine-specific phospholipase C (PC-PLC), which did not appear to desensitize within the time course employed.	Carbachol	64-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49
1361226-0	1992	Effect of carbachol on luminal release of somatostatin from isolated perfused rat duodenum.	Carbachol	10-19	somatostatin	Rattus norvegicus	42-54
1445347-1	1992	We measured dose-response curves for carbachol stimulation of phosphatidyl inositol (PI) turnover with mutants of the Hm1 muscarinic cholinergic receptor having various deletions from amino acids 219 to 358 of the large third intracellular (i3) loop (208 to 366).	Carbachol	37-46	cholinergic receptor muscarinic 1	Homo sapiens	118-121
1331363-2	1992	Activation of the nAChR by carbachol increased extracellular adenosine concentration in a dose-dependent manner.	Carbachol	27-36	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	18-23
1331363-8	1992	We found that the adenosine receptor antagonist, BW1434U, significantly inhibited carbachol-induced nAChR desensitization, indicating that extracellular adenosine is involved in nAChR desensitization.	Carbachol	82-91	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	100-105
1331363-8	1992	We found that the adenosine receptor antagonist, BW1434U, significantly inhibited carbachol-induced nAChR desensitization, indicating that extracellular adenosine is involved in nAChR desensitization.	Carbachol	82-91	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	178-183
1279850-3	1992	Furthermore, the pancreas of the rats showed good exocrine secretion of enzymes such as amylase and lipase on stimulation with carbachol in vitro.	Carbachol	127-136	lipase G, endothelial type	Rattus norvegicus	100-106
1361226-4	1992	The ratio of somatostatin-14 to somatostatin-28 in picograms was about 1 during basal release but increased to approximately 2 during carbachol stimulation.	Carbachol	134-143	somatostatin	Rattus norvegicus	13-25
1450914-0	1992	Central carbachol stimulates vasopressin release into interstitial fluid adjacent to the paraventricular nucleus.	Carbachol	8-17	arginine vasopressin	Rattus norvegicus	29-40
1445294-1	1992	Wortmannin, a specific inhibitor of myosin light chain kinase (MLCK), enhanced carbachol-induced formation of [3H]phosphatidylethanol ([3H]PEt), a marker of phospholipase D (PLD) activity, in [3H]palmitic acid-labeled PC12 cells.	Carbachol	79-88	myosin light chain kinase	Rattus norvegicus	36-61
1445294-1	1992	Wortmannin, a specific inhibitor of myosin light chain kinase (MLCK), enhanced carbachol-induced formation of [3H]phosphatidylethanol ([3H]PEt), a marker of phospholipase D (PLD) activity, in [3H]palmitic acid-labeled PC12 cells.	Carbachol	79-88	myosin light chain kinase	Rattus norvegicus	63-67
1417779-0	1992	Carbachol stimulation of phospholipase A2 and insulin secretion in pancreatic islets.	Carbachol	0-9	phospholipase A2 group IB	Homo sapiens	25-41
1417779-6	1992	Carbachol stimulation of arachidonic acid release is mediated by activation of phospholipase A2, as demonstrated by early increases in endogenous lysophosphatidylcholine.	Carbachol	0-9	phospholipase A2 group IB	Homo sapiens	79-95
1417779-7	1992	In addition to phospholipase A2 activation, carbachol-induced arachidonic acid accumulation also appears to involve diacylglycerol hydrolysis, since the diacylglycerol lipase inhibitor RG80267 partly inhibited arachidonic acid accumulation.	Carbachol	44-53	phospholipase A2 group IB	Homo sapiens	15-31
1329743-4	1992	Interestingly, carbachol, but not PDGF, induces an increase in tyrosine phosphorylation of the p125FAK and p130 v-src substrates.	Carbachol	15-24	protein tyrosine kinase 2	Homo sapiens	95-102
1395777-1	1992	To visualize ASM contraction in vitro, we measured changes in cross-sectional area and inner circumference of isolated porcine and human bronchi in response to acetylcholine or carbamylcholine chloride (Carbachol) using high-frequency ultrasound.	Carbachol	177-201	H19 imprinted maternally expressed transcript	Homo sapiens	13-16
1450914-1	1992	We have used an in vivo double microdialysis probe technique in conscious rats to determine whether the application of carbachol to one paraventricular nucleus (PVN) can result in increased local release of vasopressin from that PVN.	Carbachol	119-128	arginine vasopressin	Rattus norvegicus	207-218
1450914-4	1992	When carbachol (100 micrograms/ml) was included in the perfusate of one probe for the first 10 min of a 30-min collection period, while the other probe continued to be perfused with saline alone, there was a seven-fold increase in the concentration of vasopressin in the dialysate from the carbachol-perfused probe; the vasopressin concentration in the dialysate from the contralateral probe increased only slightly.	Carbachol	5-14	arginine vasopressin	Rattus norvegicus	252-263
1328861-2	1992	To determine whether the increases in c-fos and c-jun mRNA induced by carbachol and thrombin are sufficient to stimulate AP-1-mediated transactivation, 1321N1 cells were transfected with a reporter carrying two copies of the tetradecanoyl phorbol acetate response element and the firefly luciferase gene.	Carbachol	70-79	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
1328861-2	1992	To determine whether the increases in c-fos and c-jun mRNA induced by carbachol and thrombin are sufficient to stimulate AP-1-mediated transactivation, 1321N1 cells were transfected with a reporter carrying two copies of the tetradecanoyl phorbol acetate response element and the firefly luciferase gene.	Carbachol	70-79	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	48-53
1328861-2	1992	To determine whether the increases in c-fos and c-jun mRNA induced by carbachol and thrombin are sufficient to stimulate AP-1-mediated transactivation, 1321N1 cells were transfected with a reporter carrying two copies of the tetradecanoyl phorbol acetate response element and the firefly luciferase gene.	Carbachol	70-79	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-125
1450914-4	1992	When carbachol (100 micrograms/ml) was included in the perfusate of one probe for the first 10 min of a 30-min collection period, while the other probe continued to be perfused with saline alone, there was a seven-fold increase in the concentration of vasopressin in the dialysate from the carbachol-perfused probe; the vasopressin concentration in the dialysate from the contralateral probe increased only slightly.	Carbachol	5-14	arginine vasopressin	Rattus norvegicus	320-331
1450914-6	1992	When one of the paired probes was perfused with carbachol (100 micrograms/ml) for 30 min, there were similar increases in the concentration of vasopressin in the dialysate from both probes and a sustained increase in the plasma vasopressin concentration.	Carbachol	48-57	arginine vasopressin	Rattus norvegicus	143-154
1450914-6	1992	When one of the paired probes was perfused with carbachol (100 micrograms/ml) for 30 min, there were similar increases in the concentration of vasopressin in the dialysate from both probes and a sustained increase in the plasma vasopressin concentration.	Carbachol	48-57	arginine vasopressin	Rattus norvegicus	228-239
1415544-0	1992	CCK, bombesin, and carbachol stimulate c-fos, c-jun, and c-myc oncogene expression in rat pancreatic acini.	Carbachol	19-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-44
1505686-2	1992	The binding and interaction of carbamoylcholine with the nicotinic acetylcholine receptor was investigated using photolytically released carbamoylcholine ("caged" carbamoylcholine).	Carbachol	31-47	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	57-89
1505686-2	1992	The binding and interaction of carbamoylcholine with the nicotinic acetylcholine receptor was investigated using photolytically released carbamoylcholine ("caged" carbamoylcholine).	Carbachol	137-153	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	57-89
1505686-2	1992	The binding and interaction of carbamoylcholine with the nicotinic acetylcholine receptor was investigated using photolytically released carbamoylcholine ("caged" carbamoylcholine).	Carbachol	137-153	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	57-89
1328861-3	1992	Thrombin was significantly more effective than carbachol at stimulating AP-1-mediated transactivation.	Carbachol	47-56	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-76
1328861-4	1992	To identify the factors underlying the difference in AP-1 activity induced by carbachol and thrombin, members of the fos and jun families which encode components of AP-1 were examined.	Carbachol	78-87	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-57
1328861-5	1992	Carbachol and thrombin have similar effects on expression of c-fos, fosB, fra-2, junB, and junD, both acutely and over a 24-h time course.	Carbachol	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-66
1328861-5	1992	Carbachol and thrombin have similar effects on expression of c-fos, fosB, fra-2, junB, and junD, both acutely and over a 24-h time course.	Carbachol	0-9	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-72
1328861-5	1992	Carbachol and thrombin have similar effects on expression of c-fos, fosB, fra-2, junB, and junD, both acutely and over a 24-h time course.	Carbachol	0-9	FOS like 2, AP-1 transcription factor subunit	Homo sapiens	74-79
1328861-5	1992	Carbachol and thrombin have similar effects on expression of c-fos, fosB, fra-2, junB, and junD, both acutely and over a 24-h time course.	Carbachol	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-85
1328861-5	1992	Carbachol and thrombin have similar effects on expression of c-fos, fosB, fra-2, junB, and junD, both acutely and over a 24-h time course.	Carbachol	0-9	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-95
1328861-6	1992	However, whereas carbachol leads only to transient induction of c-jun (maximal at 0.5 h), thrombin induces a biphasic increase in c-jun mRNA--an initial peak at 0.5 h and a second, more-prolonged increase at 12 h. Thrombin but not carbachol also induces a late increase in fra-1 mRNA, which peaks at 12 h. The secondary increase in c-jun mRNA is associated with marked increases in c-Jun protein levels and AP-1 DNA-binding activity.	Carbachol	17-26	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-69
1328861-6	1992	However, whereas carbachol leads only to transient induction of c-jun (maximal at 0.5 h), thrombin induces a biphasic increase in c-jun mRNA--an initial peak at 0.5 h and a second, more-prolonged increase at 12 h. Thrombin but not carbachol also induces a late increase in fra-1 mRNA, which peaks at 12 h. The secondary increase in c-jun mRNA is associated with marked increases in c-Jun protein levels and AP-1 DNA-binding activity.	Carbachol	231-240	coagulation factor II, thrombin	Homo sapiens	90-98
1415544-0	1992	CCK, bombesin, and carbachol stimulate c-fos, c-jun, and c-myc oncogene expression in rat pancreatic acini.	Carbachol	19-28	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	57-62
1330669-4	1992	EGF, isoproterenol and NECA have no effect on basal levels of inositol phosphates (InsPs) in human RPE cells, but EGF specifically elevates the carbachol-induced stimulation of InsPs.	Carbachol	144-153	epidermal growth factor	Homo sapiens	0-3
1330669-4	1992	EGF, isoproterenol and NECA have no effect on basal levels of inositol phosphates (InsPs) in human RPE cells, but EGF specifically elevates the carbachol-induced stimulation of InsPs.	Carbachol	144-153	epidermal growth factor	Homo sapiens	114-117
1437521-2	1992	Vasoactive intestinal polypeptide (VIP) produced a dose-dependent depolarisation (EC50 = 30 nM) and an increase in membrane conductance that could be potentiated by carbachol.	Carbachol	165-174	VIP peptides	Cavia porcellus	0-33
1340058-3	1992	Using this assay, high doses of cholecystokinin or carbachol were found to stimulate the intracellular conversion of at least three zymogens (procarboxypeptidase A1, procarboxypeptidase B, and chymotrypsinogen 2) to their active forms.	Carbachol	51-60	carboxypeptidase B1	Homo sapiens	166-187
1382539-4	1992	Pretreatment of subjects with the selective histamine H1-receptor antagonist cetirizine, 10 mg orally 4 h before intradermal injections, inhibited vasodilatation caused by the intradermal injection of histamine (750 pmol), endothelin-1 (63 pmol), and carbachol (750 pmol).	Carbachol	251-260	histamine receptor H1	Homo sapiens	44-65
1436659-3	1992	Stimulation of bovine adrenal medulla by carbamoylcholine chloride induced the secretion of PC1 and PC2.	Carbachol	41-66	proprotein convertase subtilisin/kexin type 1	Bos taurus	92-95
1436659-3	1992	Stimulation of bovine adrenal medulla by carbamoylcholine chloride induced the secretion of PC1 and PC2.	Carbachol	41-66	proprotein convertase subtilisin/kexin type 2	Bos taurus	100-103
1437521-2	1992	Vasoactive intestinal polypeptide (VIP) produced a dose-dependent depolarisation (EC50 = 30 nM) and an increase in membrane conductance that could be potentiated by carbachol.	Carbachol	165-174	VIP peptides	Cavia porcellus	35-38
1332901-1	1992	I. v. administration of carbachol or neostigmine produced a dose-dependent decrease in the angiotensin I pressor response and in conversion of angiotensin I to angiotensin II in anesthetized rats.	Carbachol	24-33	angiotensinogen	Rattus norvegicus	160-174
1514577-1	1992	In rat pancreatic and submandibular gland acini during exposure to carbachol, changes in the fluorescence emission intensity ratio (R) of acini loaded with mag-fura-2 resemble changes in cytosolic Ca2+ concentration (Ca2+i) in acini loaded with fura-2.	Carbachol	67-76	carbonic anhydrase 2	Rattus norvegicus	197-200
1514577-7	1992	In acini from either gland, 1,2-bis(2-aminophenoxy)ethan-N,N,N",N"-tetraacetic acid (BAPTA) suppressed carbachol-induced Ca2+i transients.	Carbachol	103-112	carbonic anhydrase 2	Rattus norvegicus	121-124
1321772-5	1992	PACAP resembled VIP in that it stimulated a secretory response potentiated by carbachol, inhibited by bumetanide and barium chloride, and not further stimulated by the subsequent addition of VIP.	Carbachol	78-87	adenylate cyclase activating polypeptide 1	Homo sapiens	0-5
1359631-4	1992	Both intra-arterial carbachol (10(-6) M) and GRP (10(-8) M) increased acid secretion and inhibited somatostatin secretion.	Carbachol	20-29	somatostatin	Homo sapiens	99-111
1641762-8	1992	Perfusion with 10 nmol/L VIP decreased basal tone and completely abolished the contraction induced by 100 nmol/L carbachol.	Carbachol	113-122	VIP peptides	Oryctolagus cuniculus	25-28
1641762-9	1992	VIP, CGRP, and somatostatin were released from the LES in response to 10 nmol/L carbachol (VIP rose from 55 +/- 13 to 179 +/- 24 pmol/L, CGRP, from 114 +/- 30 to 239 +/- 33 pmol/L, and somatostatin from 15 +/- 2 to 27 +/- 4 pmol/L; all p less than 0.001).	Carbachol	80-89	VIP peptides	Oryctolagus cuniculus	0-3
1641762-9	1992	VIP, CGRP, and somatostatin were released from the LES in response to 10 nmol/L carbachol (VIP rose from 55 +/- 13 to 179 +/- 24 pmol/L, CGRP, from 114 +/- 30 to 239 +/- 33 pmol/L, and somatostatin from 15 +/- 2 to 27 +/- 4 pmol/L; all p less than 0.001).	Carbachol	80-89	VIP peptides	Oryctolagus cuniculus	91-94
1381656-0	1992	Substance P inhibits carbamylcholine-stimulated 22Na+ efflux from acetylcholine receptor-enriched Torpedo electroplaque membrane vesicles.	Carbachol	21-36	tachykinin precursor 1	Homo sapiens	0-11
1637359-3	1992	The electrical response to carbachol coincided with a transient translocation of PKC alpha from the soluble to the particulate fraction.	Carbachol	27-36	protein kinase C alpha	Homo sapiens	81-90
1637359-4	1992	The carbachol-, PDB- and 8-Br-cAMP-induced ISC responses were inhibited by pretreatment of the cells with PMA (0.5 microM) for 2 h, a time period in which PKC alpha, beta 1 and gamma levels were not changed.	Carbachol	4-13	protein kinase C alpha	Homo sapiens	155-164
1637359-4	1992	The carbachol-, PDB- and 8-Br-cAMP-induced ISC responses were inhibited by pretreatment of the cells with PMA (0.5 microM) for 2 h, a time period in which PKC alpha, beta 1 and gamma levels were not changed.	Carbachol	4-13	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	166-182
1330588-5	1992	Airway responsiveness was measured before and 24 h after challenge by determining the dose of inhaled carbachol that caused a 400% increase in SRL (PD400%).	Carbachol	102-111	sarcalumenin	Ovis aries	143-146
1636673-1	1992	We investigated the role of protein kinase C (PKC) in mediating carbachol"s stimulation of transepithelial Cl- secretion in T84 cells.	Carbachol	64-73	proline rich transmembrane protein 2	Homo sapiens	28-44
1636673-1	1992	We investigated the role of protein kinase C (PKC) in mediating carbachol"s stimulation of transepithelial Cl- secretion in T84 cells.	Carbachol	64-73	proline rich transmembrane protein 2	Homo sapiens	46-49
1636673-3	1992	Carbachol stimulated PKC activity, suggesting that the enzyme might participate in the hormone"s action.	Carbachol	0-9	proline rich transmembrane protein 2	Homo sapiens	21-24
1636673-5	1992	The effect of DMIs was not due to amplification of carbachol-induced increases in PKC activity, however; PKC activity during carbachol stimulation was no higher in the presence of DMIs than in their absence.	Carbachol	125-134	proline rich transmembrane protein 2	Homo sapiens	105-108
1636673-6	1992	Augmentation of carbachol"s action by DMIs appeared to be due to the direct activation of PKC which, like PMA, stimulated the Cl- conductance of the apical membrane (GCl).	Carbachol	16-25	proline rich transmembrane protein 2	Homo sapiens	90-93
1636673-6	1992	Augmentation of carbachol"s action by DMIs appeared to be due to the direct activation of PKC which, like PMA, stimulated the Cl- conductance of the apical membrane (GCl).	Carbachol	16-25	germ cell-less 2, spermatogenesis associated	Homo sapiens	166-169
1636673-7	1992	The effects of DMIs and carbachol on GCl were additive.	Carbachol	24-33	germ cell-less 2, spermatogenesis associated	Homo sapiens	37-40
1636673-8	1992	Carbachol itself stimulated GCl but not by activating PKC; staurosporine did not blunt the effect of carbachol on GCl.	Carbachol	0-9	germ cell-less 2, spermatogenesis associated	Homo sapiens	28-31
1330841-3	1992	The increase in inositol phospholipid hydrolysis induced by repeated addition of CDP-choline was obliterated when cultures were incubated in the presence of the muscarinic receptor agonist, carbamylcholine.	Carbachol	190-205	cut-like homeobox 1	Rattus norvegicus	81-84
1319463-7	1992	The CCh-induced [Ca2+]i elevation was concentration-dependently inhibited by pirenzepine and 4-diphenylacetoxy-N-methylpiperidine methiodide, two rather selective antagonists of M1 and M3 muscarinic receptor subtypes, respectively, whereas methoctramine, an M2 antagonist, was ineffective.	Carbachol	4-7	cholinergic receptor muscarinic 3	Homo sapiens	185-207
1331918-6	1992	In addition, chronic treatment (24 hrs) of SK-N-SH cells with pertussis toxin blocked 75% of the stimulatory effects of carbachol, but inhibited only 38% of the paraoxon-induced response.	Carbachol	120-129	hedgehog acyltransferase	Homo sapiens	43-47
1352680-7	1992	When either dibutyryl cAMP, forskolin or theophylline was added in culture medium with A23187, phorbol ester or carbachol, a synergistic effect was found on pancreastatin and somatostatin secretion.	Carbachol	112-121	somatostatin	Homo sapiens	175-187
1376916-11	1992	In muscle strips obtained from bladders kept empty in vivo, PTHrP-(1-34)-NH2 relaxed carbachol-induced contraction in a dose-dependent manner but failed to relax the contraction in muscle strips from distended bladders that had high endogenous PTHrP expression.	Carbachol	85-94	parathyroid hormone-like hormone	Rattus norvegicus	60-65
1378274-3	1992	IC50 of CP 96,345 for binding of [125I]-BH-SP and for SP-induced (3 x 10(-9) M) rise of [Ca2+]i were about 10(-9) M. CP-96,345 neither affected binding of [125I]-labelled Bolton-Hunter cholecystokinin octapeptide ([125I]-BH-CCK-8) nor the [Ca2+]i responses to CCK-8, carbamylcholine or bombesin.	Carbachol	267-282	tachykinin precursor 1	Homo sapiens	54-56
1393268-22	1992	Detrusor preparations contracted by carbachol were concentration-dependently relaxed by exogenously administered NO, SIN-1 (NO-donor), and isoprenaline, whereas vasoactive intestinal polypeptide had minor effects.	Carbachol	36-45	MAPK associated protein 1	Homo sapiens	117-122
1393268-23	1992	NO and SIN-1 induced maximal relaxations of 63 +/- 3% and 70 +/- 4%, respectively, of the tension induced by carbachol.	Carbachol	109-118	MAPK associated protein 1	Homo sapiens	7-12
1511949-1	1992	The stimulation of the secretion of insulin and pancreatic polypeptide (PP) by carbachol, three different neuropeptides (gastrin-releasing peptide (GRP), vasoactive intestinal polypeptide (VIP) and neuromedin C (NC)), and glucose was investigated using the isolated perfused ventral part of the rat pancreas, with or without atropine.	Carbachol	79-88	pancreatic polypeptide	Rattus norvegicus	72-74
1423494-8	1992	Furthermore, PACAP-38 (7 nmol/kg) potentiated the plasma glucagon response to the cholinergic agonist carbachol (0.16 mumol/kg).	Carbachol	102-111	adenylate cyclase activating polypeptide 1	Mus musculus	13-18
1423494-10	1992	Moreover, PACAP-38 inhibited a carbachol-induced increase in the level of plasma insulin in the absence but not in the presence of adrenergic blockade.	Carbachol	31-40	adenylate cyclase activating polypeptide 1	Mus musculus	10-15
1423494-12	1992	We conclude that PACAP-like immunoreactivity exists in nerve fibers innervating the mouse and rat pancreas, particularly the intrapancreatic ganglia, and that PACAP-38 augments both basal and carbachol-stimulated glucagon secretion in the mouse.	Carbachol	192-201	adenylate cyclase activating polypeptide 1	Mus musculus	159-164
1511949-3	1992	In addition, we studied the secretion of insulin and PP from the dorsal part of the rat pancreas in response to GRP and carbachol.	Carbachol	120-129	pancreatic polypeptide	Rattus norvegicus	53-55
1319016-6	1992	Acute (36-h) treatment with carbachol also caused an increase in VIP immunoreactivity (about 2-fold, and blocked by atropine) without an increase in VIP mRNA level.	Carbachol	28-37	vasoactive intestinal peptide	Homo sapiens	65-68
1511949-4	1992	The secretion of insulin and PP in response to carbachol and GRP were dose-dependent in range of 10(-9) M to 10(-6) M. The responses of insulin and PP to carbachol (10(-7) M) were biphasic, and were abolished by atropine (10(-5) M).	Carbachol	47-56	pancreatic polypeptide	Rattus norvegicus	29-31
1511949-4	1992	The secretion of insulin and PP in response to carbachol and GRP were dose-dependent in range of 10(-9) M to 10(-6) M. The responses of insulin and PP to carbachol (10(-7) M) were biphasic, and were abolished by atropine (10(-5) M).	Carbachol	47-56	pancreatic polypeptide	Rattus norvegicus	148-150
1511949-4	1992	The secretion of insulin and PP in response to carbachol and GRP were dose-dependent in range of 10(-9) M to 10(-6) M. The responses of insulin and PP to carbachol (10(-7) M) were biphasic, and were abolished by atropine (10(-5) M).	Carbachol	154-163	pancreatic polypeptide	Rattus norvegicus	29-31
1511949-4	1992	The secretion of insulin and PP in response to carbachol and GRP were dose-dependent in range of 10(-9) M to 10(-6) M. The responses of insulin and PP to carbachol (10(-7) M) were biphasic, and were abolished by atropine (10(-5) M).	Carbachol	154-163	gastrin releasing peptide	Rattus norvegicus	61-64
1511949-4	1992	The secretion of insulin and PP in response to carbachol and GRP were dose-dependent in range of 10(-9) M to 10(-6) M. The responses of insulin and PP to carbachol (10(-7) M) were biphasic, and were abolished by atropine (10(-5) M).	Carbachol	154-163	pancreatic polypeptide	Rattus norvegicus	148-150
1511949-10	1992	The relative secretion of PP from the dorsal vs. the ventral portions of the rat pancreas following stimulation by carbachol and GRP (10(-7) M) was 19% and 22%, respectively, while that of insulin was 289% and 382%, respectively.	Carbachol	115-124	pancreatic polypeptide	Rattus norvegicus	26-28
1504815-4	1992	Compared with vehicle control animals, carbachol treated animals showed a significantly higher number of Fos-LI cells in pontine regions implicated in REM sleep generation, with longer REMc bouts associated with more Fos-LI cells than the short-duration bout.	Carbachol	39-48	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	105-108
1504815-4	1992	Compared with vehicle control animals, carbachol treated animals showed a significantly higher number of Fos-LI cells in pontine regions implicated in REM sleep generation, with longer REMc bouts associated with more Fos-LI cells than the short-duration bout.	Carbachol	39-48	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	217-220
1319016-6	1992	Acute (36-h) treatment with carbachol also caused an increase in VIP immunoreactivity (about 2-fold, and blocked by atropine) without an increase in VIP mRNA level.	Carbachol	28-37	vasoactive intestinal peptide	Homo sapiens	149-152
1575758-5	1992	Stimulation by caerulein, carbachol, or their combination caused an immediate and significant burst in both protein and GP2 outputs.	Carbachol	26-35	glycoprotein 2	Rattus norvegicus	120-123
1590403-8	1992	The VIP-induced depolarization of Vbl was completely reversed by carbachol (0.1 mM; repolarization to -65 mV).	Carbachol	65-74	VIP peptides	Oryctolagus cuniculus	4-7
1315865-1	1992	8-Methoxy-4-[(2-isopropylphenyl)amino]-3-quinolinecarboxylate ethyl ester (AHR-9294) inhibited acid secretion stimulated by histamine, pentagastrin or carbachol in rats, and by histamine or feeding in dogs.	Carbachol	151-160	aryl hydrocarbon receptor	Rattus norvegicus	75-78
1529272-5	1992	2) PACAP significantly inhibited smooth-muscle contractions induced by acetylcholine or carbachol.	Carbachol	88-97	adenylate cyclase activating polypeptide 1	Rattus norvegicus	3-8
1575736-0	1992	Carbachol stimulation of triacylglycerol lipase activity in pancreatic acinar cells.	Carbachol	0-9	lipase C, hepatic type	Homo sapiens	25-47
1314499-3	1992	Binding of 125I-labeled PYY was rapid (70% maximal within 10 min) and specific (not inhibited by secretin, vasoactive intestinal peptide, cholecystokinin, carbachol, prostaglandin E2, forskolin, or cholera toxin).	Carbachol	155-164	peptide YY	Homo sapiens	24-27
1591273-1	1992	Agents like carbachol and cholecystokinin (CCK), that activate chief cell phosphoinositidase C, thereby increasing cell calcium concentration, increase cAMP levels in cholera toxin-treated, but not control, gastric chief cells.	Carbachol	12-21	cholecystokinin	Homo sapiens	43-46
1591273-1	1992	Agents like carbachol and cholecystokinin (CCK), that activate chief cell phosphoinositidase C, thereby increasing cell calcium concentration, increase cAMP levels in cholera toxin-treated, but not control, gastric chief cells.	Carbachol	12-21	phospholipase C beta 1	Homo sapiens	74-94
1373616-1	1992	In intact rat pancreatic acini, the phospholipase A2 inhibitor mepacrine did not affect basal amylase release but dose-dependently inhibited the carbachol (IC50 65 microM) and CCK-8 (IC50 210 microM)-stimulated amylase release.	Carbachol	145-154	phospholipase A2 group IB	Rattus norvegicus	36-52
1373616-3	1992	From these results we conclude that carbachol, CCK-8 and GTPrS probably activate a phospholipase A2 closely coupled to exocytosis.	Carbachol	36-45	phospholipase A2 group IB	Rattus norvegicus	83-99
1592746-4	1992	Airway responsiveness was measured 2 h post-PAF when sRL had returned to baseline and was expressed as the cumulative provocating dose of carbachol that increased sRL to 4 l.cmH2O.l-1.s (PD4).	Carbachol	138-147	sarcalumenin	Ovis aries	53-56
1581507-7	1992	Fourier transform infrared difference spectra calculated from spectra recorded in the presence and absence of carbamylcholine show small, reproducible bands which reflect changes in nAChR structure upon desensitization.	Carbachol	110-125	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	182-187
1620239-6	1992	We conclude that carbachol promotes Ca2+ influx via a pertussis toxin-sensitive G protein and Ca2+ mobilization via a pertussis toxin-insensitive G-protein coupling to inositol phosphate generation; NPY stimulates Ca2+ mobilization via a pertussis toxin-sensitive G protein without apparent involvement of inositol phosphates.	Carbachol	17-26	neuropeptide Y	Homo sapiens	199-202
1347975-3	1992	However, they reversed vasoactive intestinal peptide (VIP)-induced inhibition (relaxation) of carbachol-stimulated contraction.	Carbachol	94-103	VIP peptides	Cavia porcellus	54-57
1318161-4	1992	The IC50 value of nifedipine for inhibition of ET-1 mediated contractions was 3.0 +/- 0.8 x 10(-8) M. ET-1 produced a marked prolonged homologous desensitization of its contractile response but did not affect the responses mediated by carbachol, histamine, serotonin, substance P, and PLA2.	Carbachol	235-244	endothelin-1	Cavia porcellus	47-51
1318161-4	1992	The IC50 value of nifedipine for inhibition of ET-1 mediated contractions was 3.0 +/- 0.8 x 10(-8) M. ET-1 produced a marked prolonged homologous desensitization of its contractile response but did not affect the responses mediated by carbachol, histamine, serotonin, substance P, and PLA2.	Carbachol	235-244	endothelin-1	Cavia porcellus	102-106
1312458-2	1992	NE and Carb markedly enhanced PI turnover (EC50: NE, 12 microM; Carb, 661 microM) as reflected by [3H]inositol monophosphate (IP1) accumulation in tissue slices prelabeled with [3H]myoinositol.	Carbachol	7-11	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	126-129
1312458-6	1992	Preincubation of slices with various EEAs inhibited Carb-induced IP1 formation.	Carbachol	52-56	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	65-68
1380376-5	1992	However, when a tonic contraction was induced with carbachol (1 microM) a prompt relaxation was induced by substance P (1- 100 nM) and by neurokinin A (1- 100 nM), with substance P being more potent.	Carbachol	51-60	tachykinin 1	Mus musculus	107-118
1380376-5	1992	However, when a tonic contraction was induced with carbachol (1 microM) a prompt relaxation was induced by substance P (1- 100 nM) and by neurokinin A (1- 100 nM), with substance P being more potent.	Carbachol	51-60	tachykinin 1	Mus musculus	138-150
1380376-5	1992	However, when a tonic contraction was induced with carbachol (1 microM) a prompt relaxation was induced by substance P (1- 100 nM) and by neurokinin A (1- 100 nM), with substance P being more potent.	Carbachol	51-60	tachykinin 1	Mus musculus	169-180
1380376-11	1992	The selective NK1 tachykinin agonist, [Pro9]-SP sulphone (1 microM), exerted potent bronchodilator actions on carbachol-contracted mouse bronchial preparations.	Carbachol	110-119	tachykinin 1	Mus musculus	14-17
1521562-1	1992	Using a perfused rat hindleg system, release of tissue-type plasminogen activator (t-PA) from endothelial cells could be induced by platelet-activating factor (PAF), bradykinin, substance P, thrombin, carbachol and A23187, while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid.	Carbachol	201-210	plasminogen activator, tissue type	Rattus norvegicus	48-81
1521562-1	1992	Using a perfused rat hindleg system, release of tissue-type plasminogen activator (t-PA) from endothelial cells could be induced by platelet-activating factor (PAF), bradykinin, substance P, thrombin, carbachol and A23187, while this release was inhibited by mepacrine and by nor-dihydroguaiaretic acid.	Carbachol	201-210	plasminogen activator, tissue type	Rattus norvegicus	83-87
1318210-1	1992	Three peptide components of atrial natriuretic factor (ANF) caused relaxation of carbachol-contracted guinea-pig isolated tracheal smooth muscle.	Carbachol	81-90	natriuretic peptide A	Rattus norvegicus	55-58
1372804-8	1992	Calmodulin antagonists inhibited amylase secretion induced by isoproterenol plus carbamylcholine or carbamylcholine alone, but not that induced by isoproterenol alone.	Carbachol	81-96	calmodulin 1	Rattus norvegicus	0-10
1372804-8	1992	Calmodulin antagonists inhibited amylase secretion induced by isoproterenol plus carbamylcholine or carbamylcholine alone, but not that induced by isoproterenol alone.	Carbachol	100-115	calmodulin 1	Rattus norvegicus	0-10
1313646-8	1992	When hormone-stimulated C kinase activity was enhanced with the diglyceride lipase inhibitor, RG 80267, BK- and carbachol-induced increases in [Ca2+]i were blunted 50%.	Carbachol	112-121	pancreatic lipase related protein 1	Canis lupus familiaris	76-82
1545385-10	1992	In carbachol precontracted tissues, VIP elicited concentration-dependent relaxations that quickly desensitized.	Carbachol	3-12	vasoactive intestinal peptide	Sus scrofa	36-39
1592746-4	1992	Airway responsiveness was measured 2 h post-PAF when sRL had returned to baseline and was expressed as the cumulative provocating dose of carbachol that increased sRL to 4 l.cmH2O.l-1.s (PD4).	Carbachol	138-147	sarcalumenin	Ovis aries	163-166
1312940-2	1992	Low concentrations (100 nM) of cholecystokinin, neurotensin and vasoactive intestinal polypeptide (VIP), added in vitro, enhanced carbachol-stimulated phosphoinositide metabolism in cortical miniprisms from both young and senescent rats, while somatostatin was ineffective.	Carbachol	130-139	neurotensin	Rattus norvegicus	48-59
1353464-4	1992	PHI also decreased carbachol-stimulated antral gastrin release and simultaneously increased somatostatin release.	Carbachol	19-28	gastrin	Homo sapiens	47-54
1353464-7	1992	In addition, unlike its structural analogues, PHI inhibition of carbachol-stimulated gastrin release is not functionally linked to its stimulatory effects on somatostatin release.	Carbachol	64-73	gastrin	Homo sapiens	85-92
1312940-2	1992	Low concentrations (100 nM) of cholecystokinin, neurotensin and vasoactive intestinal polypeptide (VIP), added in vitro, enhanced carbachol-stimulated phosphoinositide metabolism in cortical miniprisms from both young and senescent rats, while somatostatin was ineffective.	Carbachol	130-139	vasoactive intestinal peptide	Rattus norvegicus	64-97
1312940-2	1992	Low concentrations (100 nM) of cholecystokinin, neurotensin and vasoactive intestinal polypeptide (VIP), added in vitro, enhanced carbachol-stimulated phosphoinositide metabolism in cortical miniprisms from both young and senescent rats, while somatostatin was ineffective.	Carbachol	130-139	vasoactive intestinal peptide	Rattus norvegicus	99-102
1312940-3	1992	Interestingly, the VIP receptor antagonist [d-parachloro-Phe6,Leu17[VIP shifted the dose-response curve for carbachol significantly to the right, indicating inhibition of phosphoinositide hydrolysis.	Carbachol	108-117	vasoactive intestinal peptide	Rattus norvegicus	19-22
1312940-3	1992	Interestingly, the VIP receptor antagonist [d-parachloro-Phe6,Leu17[VIP shifted the dose-response curve for carbachol significantly to the right, indicating inhibition of phosphoinositide hydrolysis.	Carbachol	108-117	vasoactive intestinal peptide	Rattus norvegicus	68-71
1310020-4	1992	Carbachol-mediated changes in neurite outgrowth, IP1 formation and [Ca2+]i displayed high sensitivity for pirenzepine but low sensitivity for AF-DX116.	Carbachol	0-9	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	49-52
1731321-2	1992	Carbachol, a muscarinic receptor agonist, stimulated both calcium influx and inositol 1,4,5-trisphosphate (InsP3)-mediated intracellular calcium release in A9 fibroblast cells expressing a m3 muscarinic receptor clone.	Carbachol	0-9	cholinergic receptor muscarinic 3	Homo sapiens	189-211
1636494-7	1992	The results of studies involving inhibitors of phospholipase A2 (PLA2) and phospholipase C (PLC) suggested that PLA2 is almost completely responsible for the Ca(2+)-dependent, carbachol-mediated AA liberation.	Carbachol	176-185	phospholipase A2 group IB	Rattus norvegicus	47-63
1636494-7	1992	The results of studies involving inhibitors of phospholipase A2 (PLA2) and phospholipase C (PLC) suggested that PLA2 is almost completely responsible for the Ca(2+)-dependent, carbachol-mediated AA liberation.	Carbachol	176-185	phospholipase A2 group IB	Rattus norvegicus	65-69
1636494-7	1992	The results of studies involving inhibitors of phospholipase A2 (PLA2) and phospholipase C (PLC) suggested that PLA2 is almost completely responsible for the Ca(2+)-dependent, carbachol-mediated AA liberation.	Carbachol	176-185	phospholipase A2 group IB	Rattus norvegicus	112-116
1609648-0	1992	Kininogen changes evoked in plasma by feeding, pseudo-alimentary, vagal and carbamylcholine stimulation of the rat.	Carbachol	76-91	kininogen 2-like 1	Rattus norvegicus	0-9
1347631-2	1992	Activation of PPI hydrolysis by carbachol elicits a robust translocation of CaM from membranes into cytosol which was previously shown to be mimicked by the addition of the calcium ionophore ionomycin and the phorbol ester TPA28.	Carbachol	32-41	calmodulin 3	Homo sapiens	76-79
1347631-9	1992	The CaM translocation with the combination of an agent that elevates cyclic AMP levels and a low dose of carbachol was not different from that observed with either agent alone.	Carbachol	105-114	calmodulin 3	Homo sapiens	4-7
1347631-10	1992	UK 14,304, DPDPE and DAMGO potentiated carbachol-stimulated increases in cytosolic CaM.	Carbachol	39-48	calmodulin 3	Homo sapiens	83-86
1620234-0	1992	Carbachol potentiates isoprenaline-induced mucin secretion by rat submandibular gland.	Carbachol	0-9	solute carrier family 13 member 2	Rattus norvegicus	43-48
1583072-1	1992	Stimulation of chief cells with carbachol or cholecystokinin (CCK) results in the production of inositol trisphosphate (IP3) and diacylglycerol (DAG).	Carbachol	32-41	cholecystokinin	Homo sapiens	62-65
1364146-11	1992	Taken together with previous results showing that the activation of 5HT1C/5HT2 receptors promotes a reduction of the dipsogenic response evoked by water deprivation or by icv injection of angiotensin II or carbachol, the present data suggest that the central serotoninergic system plays a ubiquitous role in the modulation of water intake behavior.	Carbachol	206-215	5-hydroxytryptamine receptor 2C	Rattus norvegicus	68-73
1283979-2	1992	Calmodulin inhibitor (W-7, 100 microM) and Ca2+/CaM kinase II inhibitor (KN-62, 10 microM) reduced amylase secretion stimulated by cholecystokinin (CCK) or carbachol.	Carbachol	156-165	calmodulin 1	Rattus norvegicus	0-10
1727052-7	1992	Moreover, carbachol inhibited the mitogenic effect of thyroid stimulating hormone (TSH) and of epidermal growth factor (EGF).	Carbachol	10-19	epidermal growth factor	Canis lupus familiaris	95-118
1727052-7	1992	Moreover, carbachol inhibited the mitogenic effect of thyroid stimulating hormone (TSH) and of epidermal growth factor (EGF).	Carbachol	10-19	epidermal growth factor	Canis lupus familiaris	120-123
1727052-9	1992	Nevertheless, carbachol enhanced the expression of the protooncogenes c-fos and c-myc mRNAs.	Carbachol	14-23	MYC proto-oncogene, bHLH transcription factor	Canis lupus familiaris	80-85
1596675-13	1992	At 10 microM, the highest concentration ?tsed, ET-1 produced similar levels of [3H]-InsP accumulation (7.03 +/- 0.55 fold above basal levels, t = 5) to that produced by a maximally effective concentration of carbachol (10 microM; 7.97 +/- 0.31 fold increase above basal levels, n = 4).	Carbachol	208-217	endothelin 1	Rattus norvegicus	47-51
1596675-16	1992	The mean concentration of ET-1 producing 50% of the maximum contractile response to carbachol (EC50) was 31 nm (95% confidence limits, 20-49 nM, n = 12).	Carbachol	84-93	endothelin 1	Rattus norvegicus	26-30
1285949-4	1992	Although carbachol or trihexyphenidyl alone was ineffective in inducing c-fos mRNA, the combination of levodopa and carbachol (> or = to 0.1 mg/kg) significantly suppressed the induction of c-fos mRNA as compared with levodopa given alone.	Carbachol	116-125	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	193-198
1581016-2	1992	The effect of direct stimulation of the rostral TRN by the cholinergic agonist carbachol on the behaviour of freely moving rats was observed.	Carbachol	79-88	transfer RNA asparagine 1 (anticodon GUU)	Rattus norvegicus	48-51
1581016-3	1992	Unilateral injection of carbachol (0.2-3.2 micrograms/0.5 microliters) into the rostral TRN caused catalepsy which appeared rapidly and was short-lasting.	Carbachol	24-33	transfer RNA asparagine 1 (anticodon GUU)	Rattus norvegicus	88-91
19215537-7	1991	Inhibition of protein kinase C by sphingosine or by long-term treatment with phorbol esters, completely abolished the synthesis of CGA and CGB induced by carbamylcholine, bradykinin and prostaglandin E(2) but decreased only partially the stimulating effect of histamine.	Carbachol	154-169	chromogranin A	Bos taurus	131-134
1531470-1	1992	Both carbachol (10(-4)-10(-3) mol/l) and cholecystokinin octapeptide (CCK-8) (10(-8)-10(-6) mol/l) significantly stimulated the release of pepsinogen from rabbit gastric mucosa maintained in organ culture (213-216% and 143-261% of control, respectively, p less than 0.05-0.01).	Carbachol	5-14	pepsin II-2/3	Oryctolagus cuniculus	139-149
1531470-5	1992	W-7 (10(-6)-10(-4) mol/l) and W-5 (10(-5) and 10(-4), or 10(-6) mol/l) reduced significantly the secretion of pepsinogen induced by carbachol (53-71% and 63-81% of control, respectively, p less than 0.05-0.01) and that by CCK-8 (49-67% and 66-76% of control, respectively, p less than 0.01) in the Ca2+ containing medium.	Carbachol	132-141	pepsin II-2/3	Oryctolagus cuniculus	110-120
1531470-7	1992	These findings indicate that the calmodulin messenger branch that is activated by a rise of intracellular Ca2+ mobilised in cytosol from its intracellular, but not extracellular, source plays a critical role in pepsinogen secretion induced by carbachol and CCK-8.	Carbachol	243-252	calmodulin	Oryctolagus cuniculus	33-43
1531470-7	1992	These findings indicate that the calmodulin messenger branch that is activated by a rise of intracellular Ca2+ mobilised in cytosol from its intracellular, but not extracellular, source plays a critical role in pepsinogen secretion induced by carbachol and CCK-8.	Carbachol	243-252	pepsin II-2/3	Oryctolagus cuniculus	211-221
1641133-10	1992	In contrast to the increased mRNA levels, nicotine and carbachol reduce the interleukin-1 alpha protein level measured in the rat adrenal gland: nicotine by approximately 30%, 60 min after injection, and carbachol by approximately 55%, 30 min after injection.	Carbachol	55-64	interleukin 1 alpha	Rattus norvegicus	76-95
1641133-10	1992	In contrast to the increased mRNA levels, nicotine and carbachol reduce the interleukin-1 alpha protein level measured in the rat adrenal gland: nicotine by approximately 30%, 60 min after injection, and carbachol by approximately 55%, 30 min after injection.	Carbachol	204-213	interleukin 1 alpha	Rattus norvegicus	76-95
1641133-11	1992	The interleukin-1 alpha protein level returns to control level 90 min after nicotine injection, and 120 min after carbachol injection.	Carbachol	114-123	interleukin 1 alpha	Rattus norvegicus	4-23
1940918-5	1991	Atropine, hexahydrosiladifenidol (HHSD), pirenzepine, and methoctramine inhibited the carbachol-evoked initial calcium transient with Ki values of 0.85 +/- 0.05, 8.3 +/- 1.6, 411 +/- 36, and 240 +/- 46 nM (mean +/- SEM, n = 3), respectively, and the acetylcholine-induced initial calcium transient with Ki values of 0.48 +/- 0.18, 13.5 +/- 8.5, 192 +/- 32, and 414 +/- 25 nM (mean +/- SEM of two experiments), respectively, results suggesting that an M3 muscarinic receptor was predominantly mediating these effects.	Carbachol	86-95	cholinergic receptor muscarinic 3	Homo sapiens	451-473
1668612-4	1991	Carbachol decreased the Ca-inward current, and probably it prevented the calmodulin activation.	Carbachol	0-9	calmodulin	Oryctolagus cuniculus	73-83
1667338-5	1991	A direct relaxant effect of CGRP on smooth muscle tone of carbachol precontracted preparations was only observed in specimens of the guinea-pig.	Carbachol	58-67	calcitonin related polypeptide alpha	Homo sapiens	28-32
1478730-4	1992	Proenkephalin mRNA expression was stimulated by IL-1 beta in a time- and concentration-dependent manner, being maximal with 5 U/ml IL-1 beta at 4 h. Although the beta-adrenergic agonist isoproterenol was also active, interferon, glutamate, and carbachol were not.	Carbachol	244-253	proenkephalin	Rattus norvegicus	0-13
1478730-4	1992	Proenkephalin mRNA expression was stimulated by IL-1 beta in a time- and concentration-dependent manner, being maximal with 5 U/ml IL-1 beta at 4 h. Although the beta-adrenergic agonist isoproterenol was also active, interferon, glutamate, and carbachol were not.	Carbachol	244-253	interleukin 1 beta	Rattus norvegicus	48-57
1579044-3	1992	We now report that central administration of AII antagonists [either (Sar-1, Ile-8) AII or (Sar-1, Ala-8) AII] in rats prevents the majority (greater than 70%) of the pressor effects of intraventricular vasopressin or carbachol.	Carbachol	218-227	angiotensinogen	Rattus norvegicus	45-48
1641388-4	1992	Purified porcine PEC-60 was injected intravenously in mice at 1 or 8 nmol/kg alone or together with glucose (2.8 mmol/kg) or the cholinergic agonist carbachol (0.16 mumol/kg).	Carbachol	149-158	serine peptidase inhibitor, Kazal type 4	Rattus norvegicus	17-23
1641388-5	1992	PEC-60 was found to inhibit glucose- and carbachol-induced insulin secretion (p less than 0.01 and p less than 0.05, respectively) at 8 nmol/kg, whereas at 1 nmol/kg, the peptide had no effect.	Carbachol	41-50	serine peptidase inhibitor, Kazal type 4	Rattus norvegicus	0-6
1466092-2	1992	VIP caused a weak contraction and a small potentiation of carbachol- and acetylcholine-induced contractions.	Carbachol	58-67	vasoactive intestinal peptide	Rattus norvegicus	0-3
1722647-0	1991	Carbachol acts through protein kinase C to modulate cholecystokinin receptors on pancreatic acini.	Carbachol	0-9	cholecystokinin	Rattus norvegicus	52-67
1722647-4	1991	Preincubation with 0.1 mM carbachol for 60 min reduced the CCK octapeptide (CCK-8; 100 pM)-stimulated amylase release by 43 +/- 5%.	Carbachol	26-35	cholecystokinin	Rattus norvegicus	59-62
1722647-4	1991	Preincubation with 0.1 mM carbachol for 60 min reduced the CCK octapeptide (CCK-8; 100 pM)-stimulated amylase release by 43 +/- 5%.	Carbachol	26-35	cholecystokinin	Rattus norvegicus	76-79
1722647-7	1991	Preincubation of acini with 12-O-tetradecanoylphorbol 12,13-acetate (TPA, 1 microM), an activator of protein kinase C (PKC), decreased subsequent CCK-8-stimulated amylase release, and total binding of 125I-BH-CCK-8 to a similar extent as with pretreatment with CCh.	Carbachol	261-264	cholecystokinin	Rattus norvegicus	146-149
1722647-8	1991	The inhibitory effect of TPA or CCh on CCK-8-stimulated amylase release was reversed by simultaneous preincubation with H-7, an inhibitor of PKC.	Carbachol	32-35	cholecystokinin	Rattus norvegicus	39-42
1722647-10	1991	After CCh or TPA preincubation, CCK-8-stimulated production of [3H]inositol phosphates was inhibited by at least 49%.	Carbachol	6-9	cholecystokinin	Rattus norvegicus	32-35
1767816-7	1991	The pharmacological response of functional mAChRs, determined as accumulation of inositol phosphates induced by carbachol, is greater in the medium containing IGF-I and Ins than those cultured in 1% FBS.	Carbachol	112-121	insulin like growth factor 1	Homo sapiens	159-164
1667295-0	1991	Chronic treatment with the angiotensin I converting enzyme inhibitor, perindopril, protects in vitro carbachol-induced vasorelaxation in a rat model of vascular calcium overload.	Carbachol	101-110	angiotensin I converting enzyme	Rattus norvegicus	27-58
19215537-4	1991	Incubation of cells with carbamylcholine, nigh K(+) or histamine, three potent stimulators of catecholamine secretion in chromaffin cells, increased the rate of CGA and CGB synthesis.	Carbachol	25-40	chromogranin A	Bos taurus	161-164
19215537-4	1991	Incubation of cells with carbamylcholine, nigh K(+) or histamine, three potent stimulators of catecholamine secretion in chromaffin cells, increased the rate of CGA and CGB synthesis.	Carbachol	25-40	chromogranin B	Bos taurus	169-172
19215537-7	1991	Inhibition of protein kinase C by sphingosine or by long-term treatment with phorbol esters, completely abolished the synthesis of CGA and CGB induced by carbamylcholine, bradykinin and prostaglandin E(2) but decreased only partially the stimulating effect of histamine.	Carbachol	154-169	chromogranin B	Bos taurus	139-142
1815136-3	1991	A series of cis- and trans-decahydroquinolines with substituents in the 2- and 5-position also exhibit structure-dependent inhibition of carbamylcholine-elicited sodium flux in PC12 cells and all of the decahydroquinolines inhibit binding of the noncompetitive blocking agent [3H]perhydrohistrionicotoxin to muscle-type nicotinic acetylcholine receptor-channels in membranes from Torpedo electroplax.	Carbachol	137-152	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	320-352
1761164-3	1991	Maximal augmentation of the TRH-induced prolactin mRNA accumulation was obtained when cells were pretreated with 10(-5) M ACh for 24 h. The activation was mimicked by carbachol and oxotremorine and was blocked by the simultaneous presence of atropine.	Carbachol	167-176	thyrotropin releasing hormone	Rattus norvegicus	28-31
1761164-3	1991	Maximal augmentation of the TRH-induced prolactin mRNA accumulation was obtained when cells were pretreated with 10(-5) M ACh for 24 h. The activation was mimicked by carbachol and oxotremorine and was blocked by the simultaneous presence of atropine.	Carbachol	167-176	prolactin	Rattus norvegicus	40-49
1745608-0	1991	Effects of Ca2+ removal and of tetraethylammonium on membrane currents induced by carbachol in isolated cells from the rat parotid gland.	Carbachol	82-91	carbonic anhydrase 2	Rattus norvegicus	11-14
1723045-2	1991	Neurokinin A and substance P produced concentration-dependent contractions which approached 80-90% of the maximal response to carbachol.	Carbachol	126-135	tachykinin precursor 1	Homo sapiens	0-12
1723045-2	1991	Neurokinin A and substance P produced concentration-dependent contractions which approached 80-90% of the maximal response to carbachol.	Carbachol	126-135	tachykinin precursor 1	Homo sapiens	17-28
1660519-4	1991	The specifically bound ANF could be displaced completely by unlabelled ANF(1-28) (biologically active circulating form of ANF), partially (approximately 50%) by the clearance receptor (ANF-R2) ligand, ANF(4-23), and insignificantly by angiotensin II, vasopressin, carbachol and progesterone.	Carbachol	264-273	natriuretic peptide A	Rattus norvegicus	23-26
1660519-4	1991	The specifically bound ANF could be displaced completely by unlabelled ANF(1-28) (biologically active circulating form of ANF), partially (approximately 50%) by the clearance receptor (ANF-R2) ligand, ANF(4-23), and insignificantly by angiotensin II, vasopressin, carbachol and progesterone.	Carbachol	264-273	natriuretic peptide A	Rattus norvegicus	71-74
1660519-4	1991	The specifically bound ANF could be displaced completely by unlabelled ANF(1-28) (biologically active circulating form of ANF), partially (approximately 50%) by the clearance receptor (ANF-R2) ligand, ANF(4-23), and insignificantly by angiotensin II, vasopressin, carbachol and progesterone.	Carbachol	264-273	natriuretic peptide A	Rattus norvegicus	71-74
1660519-4	1991	The specifically bound ANF could be displaced completely by unlabelled ANF(1-28) (biologically active circulating form of ANF), partially (approximately 50%) by the clearance receptor (ANF-R2) ligand, ANF(4-23), and insignificantly by angiotensin II, vasopressin, carbachol and progesterone.	Carbachol	264-273	natriuretic peptide A	Rattus norvegicus	71-74
1660519-4	1991	The specifically bound ANF could be displaced completely by unlabelled ANF(1-28) (biologically active circulating form of ANF), partially (approximately 50%) by the clearance receptor (ANF-R2) ligand, ANF(4-23), and insignificantly by angiotensin II, vasopressin, carbachol and progesterone.	Carbachol	264-273	natriuretic peptide A	Rattus norvegicus	71-74
1686865-3	1991	Here we report the time course of the appearance of the 3,5-dibromo-4-nitrosobenzene sulfonate (DBNBS) spin adduct and cyclic GMP formation following addition of carbamylcholine to suspensions of cultured mouse neuroblastoma cells (clone N1E-115).	Carbachol	162-177	5'-nucleotidase, cytosolic II	Mus musculus	126-129
1745608-5	1991	When pipettes contained no ATP, responses evoked by repeated applications of 10 microM carbachol (0.5-1 min) at 1.5-4 min intervals decreased only slowly after Ca2+ removal, outward currents being reduced to 90 +/- 6% and inward currents to 47 +/- 11% (n = 6) in 10 min.	Carbachol	87-96	carbonic anhydrase 2	Rattus norvegicus	160-163
1745608-6	1991	On the other hand, when 5 mM ATP was included in the electrodes, Ca2+ removal abolished the carbachol responses in about 5 min (n = 4).	Carbachol	92-101	carbonic anhydrase 2	Rattus norvegicus	65-68
1887927-10	1991	These results suggest that microinjection of NPY or carbachol into the posterior hypothalamic nucleus of conscious rats evokes an increase in MAP primarily as a result of sympathoexcitation and that NPY and carbachol selectively affect autonomic nervous system control of the cardiovascular system.	Carbachol	52-61	neuropeptide Y	Rattus norvegicus	199-202
1910075-14	1991	Ca(2+)-dependent and carbachol-mediated AA liberation occurs mainly as the result of PLA2 action.	Carbachol	21-30	phospholipase A2 group IB	Rattus norvegicus	85-89
1724672-0	1991	Effect of external Cd2+ and other divalent cations on carbachol-activated non-selective cation channels in guinea-pig ileum.	Carbachol	54-63	T-cell surface antigen CD2	Cavia porcellus	19-22
1724672-7	1991	The inhibitory action of Cd2+ was associated neither with agonist concentration (CCh) nor with changes in reversal potential, and was voltage independent.	Carbachol	81-84	T-cell surface antigen CD2	Cavia porcellus	25-28
1887927-10	1991	These results suggest that microinjection of NPY or carbachol into the posterior hypothalamic nucleus of conscious rats evokes an increase in MAP primarily as a result of sympathoexcitation and that NPY and carbachol selectively affect autonomic nervous system control of the cardiovascular system.	Carbachol	207-216	neuropeptide Y	Rattus norvegicus	45-48
1787877-4	1991	Cholinergic receptor agonists such as methacholine (10 microM), carbachol (10 microM), and oxotremorine (10 microM) inhibited the activity of serotonin N-acetyltransferase in the bovine pineal explants in culture, from a control value of 5.02 +/- 0.45 to 1.25 +/- 0.25, 1.30 +/- 0.15, and 1.22 +/- 0.20 pmol/mg protein/min, respectively.	Carbachol	64-73	serotonin N-acetyltransferase	Bos taurus	142-171
1679122-11	1991	Carbachol, a nonhydrolyzable cholinergic agonist, and 5-HT quickly and reversibly increased the amplitude of the LTT Ca2+ current.	Carbachol	0-9	carbonic anhydrase 2	Rattus norvegicus	117-120
1877699-2	1991	The intracerebroventricular (icv) administration of carbachol (25 ng) resulted in marked transient increases in the plasma vasopressin concentration and mean arterial blood pressure and a transient reduction in heart rate.	Carbachol	52-61	arginine vasopressin	Rattus norvegicus	123-134
1720905-3	1991	In the presence of a submaximal dose of PACAP 38 (1 nM), amylase release stimulated by an agonist working via the elevation of intracellular cyclic AMP (VIP, dibutyryl cAMP) was additionally responded, but the amylase release stimulated by an agonist via the elevation of cytosolic free calcium (carbachol, cholecystokinin) was potentiated synergistically.	Carbachol	296-305	vasoactive intestinal peptide	Rattus norvegicus	153-156
1719434-12	1991	Both substance P and carbachol showed a concentration-related increase in accumulation of total inositol phosphates; though the maximal response to carbachol was considerably greater than that to any tachykinin (substance P, eledoisin, substance P methyl ester, senktide, neurokinin A, neurokinin B), or combination of two tachykinins (substance P and eledoisin, senktide and substance P methyl ester).	Carbachol	21-30	tachykinin-3	Cavia porcellus	286-298
1719434-12	1991	Both substance P and carbachol showed a concentration-related increase in accumulation of total inositol phosphates; though the maximal response to carbachol was considerably greater than that to any tachykinin (substance P, eledoisin, substance P methyl ester, senktide, neurokinin A, neurokinin B), or combination of two tachykinins (substance P and eledoisin, senktide and substance P methyl ester).	Carbachol	148-157	tachykinin-3	Cavia porcellus	286-298
1858855-2	1991	The frequency of oscillations increased in graded fashion with [CCh] between 25 nM (2.7 +/- 0.6 min-1) and 250 nM (11.8 +/- 1.4 min-1), whereas the amplitude of the spikes was independent of [CCh].	Carbachol	64-67	CD59 molecule (CD59 blood group)	Homo sapiens	96-101
1712584-0	1991	Carbachol enhances forskolin-stimulated cyclic AMP accumulation via activation of calmodulin system in human neuroblastoma SH-SY5Y cells.	Carbachol	0-9	calmodulin 1	Homo sapiens	82-92
1712584-6	1991	The enhancing response of carbachol was sensitive to trifluoperazine but insensitive to calphostin C. These results suggest that the mechanism for carbachol-induced cAMP levels may act, at least in part, through the activation of calmodulin system in SH-SY5Y cells.	Carbachol	26-35	calmodulin 1	Homo sapiens	230-240
1712584-6	1991	The enhancing response of carbachol was sensitive to trifluoperazine but insensitive to calphostin C. These results suggest that the mechanism for carbachol-induced cAMP levels may act, at least in part, through the activation of calmodulin system in SH-SY5Y cells.	Carbachol	147-156	calmodulin 1	Homo sapiens	230-240
1712584-7	1991	Hence we describe for the first time a synergistic interaction between calmodulin- and cAMP-dependent signal transduction pathway mediated by carbachol in neuron-derived cell line.	Carbachol	142-151	calmodulin 1	Homo sapiens	71-81
1678851-8	1991	The administration of carbachol also stimulates rat adrenomedullary tyrosine hydroxylase gene transcription rate.	Carbachol	22-31	tyrosine hydroxylase	Rattus norvegicus	68-88
1649147-6	1991	ET1-stimulated IP3 production is dose dependent with an EC50 of 45 nM, this value is about 100- and 56-fold lower than those we reported for substance P and carbachol, respectively.	Carbachol	157-166	endothelin-1	Oryctolagus cuniculus	0-3
1716708-4	1991	This carbachol-stimulated amylase release showed a biphasic curve, and its maximal response was observed at 10(-5) M. The release patterns of chymotrypsinogen and lipase were similar to that of amylase.	Carbachol	5-14	lipase G, endothelial type	Rattus norvegicus	163-169
1683694-3	1991	In contrast, the ability of isoprenaline to relax longitudinal smooth muscle precontracted with carbachol was significantly (p less than 0.02) reduced in the twenty-four month age group.	Carbachol	96-105	neurogenin 3	Rattus norvegicus	44-49
1876601-4	1991	The purpose of this study was to examine the effects of IAPP and CGRP on glucose- and carbachol-stimulated release of insulin and pancreatic polypeptide (PP) from the isolated perfused rat pancreas.	Carbachol	86-95	pancreatic polypeptide	Rattus norvegicus	130-157
1716742-3	1991	NKA contracted large and small airways to a different extent (56% vs 92% of carbachol maximal contraction, respectively).	Carbachol	76-85	tachykinin precursor 1	Homo sapiens	0-3
1716742-5	1991	SP had a lower contractile effect in large (26% carbachol maximum) and small airways (59%) with EC50 values higher than 0.5 microM.	Carbachol	48-57	tachykinin precursor 1	Homo sapiens	0-2
1876601-6	1991	At the same concentration, however, IAPP significantly (p less than 0.05) inhibited carbachol-stimulated (10(-7) M) release of insulin by 30%, and CGRP significantly inhibited carbachol-stimulated release of insulin by 33% when compared with the control group.	Carbachol	84-93	islet amyloid polypeptide	Homo sapiens	36-40
1876601-6	1991	At the same concentration, however, IAPP significantly (p less than 0.05) inhibited carbachol-stimulated (10(-7) M) release of insulin by 30%, and CGRP significantly inhibited carbachol-stimulated release of insulin by 33% when compared with the control group.	Carbachol	84-93	insulin	Homo sapiens	127-134
1876601-6	1991	At the same concentration, however, IAPP significantly (p less than 0.05) inhibited carbachol-stimulated (10(-7) M) release of insulin by 30%, and CGRP significantly inhibited carbachol-stimulated release of insulin by 33% when compared with the control group.	Carbachol	176-185	calcitonin related polypeptide alpha	Homo sapiens	147-151
1876601-6	1991	At the same concentration, however, IAPP significantly (p less than 0.05) inhibited carbachol-stimulated (10(-7) M) release of insulin by 30%, and CGRP significantly inhibited carbachol-stimulated release of insulin by 33% when compared with the control group.	Carbachol	176-185	insulin	Homo sapiens	208-215
1876601-7	1991	IAPP also significantly decreased carbachol-stimulated release release of PP.	Carbachol	34-43	islet amyloid polypeptide	Homo sapiens	0-4
1876601-7	1991	IAPP also significantly decreased carbachol-stimulated release release of PP.	Carbachol	34-43	pancreatic polypeptide	Rattus norvegicus	2-4
1710445-2	1991	The bFGF-mediated calcium transient was not dependent on the presence of extracellular calcium, and was abolished by pretreatment of acini with carbachol.	Carbachol	144-153	fibroblast growth factor 2	Rattus norvegicus	4-8
1768254-1	1991	Ornithine decarboxylase in a human parotid gland adenocarcinoma cell line was induced by both cholinergic (carbachol) and beta-adrenergic (isoproterenol) sialagogues.	Carbachol	107-116	ornithine decarboxylase 1	Homo sapiens	0-23
2054187-5	1991	Muscarinic activation, either by repetitive stimulation of cholinergic fibers or by bath-applied carbachol, strongly increased intradendritic Ca2+ accumulation during directly evoked repetitive firing, in part by blocking a Ca(2+)-dependent K+ conductance.	Carbachol	97-106	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	142-145
2013756-9	1991	These results demonstrate that phospholipase C hydrolysis of exogenous PI by rabbit cortical membranes may be stimulated by carbachol in a guanine nucleotide-dependent manner.	Carbachol	124-133	LOC100009319	Oryctolagus cuniculus	31-46
2042942-6	1991	M1 muscarinic receptors exhibited both high (KH) and low (KL) affinities for the agonist carbachol.	Carbachol	89-98	klotho	Homo sapiens	58-60
1681055-10	1991	The negative inotropic responses of the A1-adenosine receptor agonist L-phenylisopropyladenosine (L-PIA) were also antagonized by 4-AP, but to a lesser extent than for carbachol.	Carbachol	168-177	adenosine receptor A1	Cavia porcellus	40-61
1902229-4	1991	Using the stable acetylcholine analog carbachol to activate muscarinic receptors (mAChR) in a glial cell line (1321N1), we show that c-fos and c-jun mRNA levels are transiently increased, reaching a maximum at 30 min after agonist addition.	Carbachol	38-47	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	133-138
1902229-4	1991	Using the stable acetylcholine analog carbachol to activate muscarinic receptors (mAChR) in a glial cell line (1321N1), we show that c-fos and c-jun mRNA levels are transiently increased, reaching a maximum at 30 min after agonist addition.	Carbachol	38-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-148
1902229-5	1991	Experiments in which the actions of carbachol are blocked by adding atropine at various times demonstrate that only 1.5 min of agonist stimulation is needed to give maximal increases in c-fos or c-jun mRNA at 30 min.	Carbachol	36-45	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	186-191
1902229-5	1991	Experiments in which the actions of carbachol are blocked by adding atropine at various times demonstrate that only 1.5 min of agonist stimulation is needed to give maximal increases in c-fos or c-jun mRNA at 30 min.	Carbachol	36-45	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	195-200
1902229-7	1991	In cells in which protein kinase C has been down-regulated, carbachol no longer stimulates c-fos or c-jun expression, indicating a critical role for protein kinase C in these responses.	Carbachol	60-69	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-96
1902229-7	1991	In cells in which protein kinase C has been down-regulated, carbachol no longer stimulates c-fos or c-jun expression, indicating a critical role for protein kinase C in these responses.	Carbachol	60-69	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-105
1902229-9	1991	The strong enhancement of c-jun induction by carbachol in BAPTA-treated cells is due at least in part to mRNA stabilization.	Carbachol	45-54	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-31
1708286-10	1991	The results suggest that the inhibitory effects of CCK and carbachol on net protein synthesis are due to their effects on intracellular calcium and PLA-mediated breakdown of phosphatidylcholine rather than protein kinase C activation.	Carbachol	59-68	phospholipase A and acyltransferase 1	Rattus norvegicus	148-151
1848278-0	1991	Potential mechanisms involved in the negative coupling between serotonin 5-HT1A receptors and carbachol-stimulated phosphoinositide turnover in the rat hippocampus.	Carbachol	94-103	5-hydroxytryptamine receptor 1A	Rattus norvegicus	73-79
1848278-2	1991	In the present study, we have investigated further the pharmacological specificity of this negative control and attempted to elucidate the mechanism whereby 5-HT1A receptor activation inhibits the carbachol-stimulated phosphoinositide response in immature or adult rat hippocampal slices.	Carbachol	197-206	5-hydroxytryptamine receptor 1A	Rattus norvegicus	157-163
1848278-4	1991	The potency of the 5-HT1A receptor agonists investigated as inhibitors of the carbachol response was well correlated (r = 0.92) with their potency as inhibitors of the forskolin-stimulated adenylate cyclase in guinea pig hippocampal membranes.	Carbachol	78-87	5-hydroxytryptamine receptor 1A	Rattus norvegicus	19-25
1848278-9	1991	Moreover, the inhibitory effect of 8-OH-DPAT on the carbachol response was blocked by 10 microM quinacrine (a phospholipase A2 inhibitor) but not by BW 755C (100 microM), a cyclooxygenase and lipoxygenase inhibitor.	Carbachol	52-61	phospholipase A2 group IB	Rattus norvegicus	110-126
1848278-10	1991	These results collectively suggest that 5-HT1A receptor activation inhibits carbachol-stimulated phosphoinositide turnover by stimulating a phospholipase A2 coupled to 5-HT1A receptors, leading to arachidonic acid release.	Carbachol	76-85	5-hydroxytryptamine receptor 1A	Rattus norvegicus	40-46
1848278-10	1991	These results collectively suggest that 5-HT1A receptor activation inhibits carbachol-stimulated phosphoinositide turnover by stimulating a phospholipase A2 coupled to 5-HT1A receptors, leading to arachidonic acid release.	Carbachol	76-85	phospholipase A2 group IB	Rattus norvegicus	140-156
1848278-10	1991	These results collectively suggest that 5-HT1A receptor activation inhibits carbachol-stimulated phosphoinositide turnover by stimulating a phospholipase A2 coupled to 5-HT1A receptors, leading to arachidonic acid release.	Carbachol	76-85	5-hydroxytryptamine receptor 1A	Rattus norvegicus	168-174
1900518-5	1991	Likewise, IFN-gamma potentiated the action of the muscarinic agonist carbachol.	Carbachol	69-78	interferon gamma	Rattus norvegicus	10-19
2002334-2	1991	Chronic (3-72-h) agonist (nicotine or carbamylcholine) treatment of cells led to a complete (TE671) or nearly complete (PC12) loss of functional nAChR responses, which is referred to as "functional inactivation."	Carbachol	38-53	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	145-150
2002334-8	1991	Recovery of TE671 cell nAChR function following treatment with carbamylcholine, nicotine, or d-TC occurred with half-times of 1-3 days whether cells were maintained in situ or harvested and replated after removal of ligand.	Carbachol	63-78	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	23-28
2002344-3	1991	In addition, in the presence of ethanol (170-300 mM), CCh elevated levels of [3H]PEt [which is regarded as a specific indicator of phospholipase D (PLD) activity] by three- to sixfold.	Carbachol	54-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	131-146
2002344-3	1991	In addition, in the presence of ethanol (170-300 mM), CCh elevated levels of [3H]PEt [which is regarded as a specific indicator of phospholipase D (PLD) activity] by three- to sixfold.	Carbachol	54-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	148-151
1831422-0	1991	The release of atrial natriuretic factor induced by central carbachol injection may be mediated by muscarinic M1 receptors.	Carbachol	60-69	natriuretic peptide A	Rattus norvegicus	15-40
1831422-1	1991	We investigated the effect of selective muscarinic antagonists on atrial natriuretic factor (ANF) release induced by intracerebroventricular (i.c.v) injection of carbachol in the rat.	Carbachol	162-171	natriuretic peptide A	Rattus norvegicus	66-91
1831422-1	1991	We investigated the effect of selective muscarinic antagonists on atrial natriuretic factor (ANF) release induced by intracerebroventricular (i.c.v) injection of carbachol in the rat.	Carbachol	162-171	natriuretic peptide A	Rattus norvegicus	93-96
1831422-4	1991	4-Diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP), a rather selective M1 and M3 receptor antagonist, was the most potent inhibitor of carbachol-induced ANF release, its ID50 being 0.18 nmol/rat.	Carbachol	141-150	natriuretic peptide A	Rattus norvegicus	159-162
1831422-7	1991	The selective M2 receptor antagonist, methoctramine, on the other hand, was a very weak inhibitor of carbachol-induced ANF release.	Carbachol	101-110	natriuretic peptide A	Rattus norvegicus	119-122
2005087-5	1991	In contrast, the induction of TIS1 by NGF and TPA is slight and is only just detectable after stimulation by bFGF, but is strong for carbachol.	Carbachol	133-142	nerve growth factor	Rattus norvegicus	38-41
1848233-5	1991	The loss of response for both groups of agonists could be prevented if the incubation temperature was maintained at 37 degrees C, rather than at 10 degrees C. At the latter temperature carbachol pretreatment of SK-N-SH cells reduced the maximum release of inositol phosphates elicited by either carbachol or L-670,548 but not the agonist concentrations required for half-maximal stimulation.	Carbachol	185-194	hedgehog acyltransferase	Homo sapiens	211-215
1848233-5	1991	The loss of response for both groups of agonists could be prevented if the incubation temperature was maintained at 37 degrees C, rather than at 10 degrees C. At the latter temperature carbachol pretreatment of SK-N-SH cells reduced the maximum release of inositol phosphates elicited by either carbachol or L-670,548 but not the agonist concentrations required for half-maximal stimulation.	Carbachol	295-304	hedgehog acyltransferase	Homo sapiens	211-215
1704418-0	1991	Galanin reduces carbachol stimulation of phosphoinositide turnover in rat ventral hippocampus by lowering Ca2+ influx through voltage-sensitive Ca2+ channels.	Carbachol	16-25	galanin and GMAP prepropeptide	Rattus norvegicus	0-7
1364828-2	1991	The effects of vasoactive intestinal peptide (VIP) on contractile responses to carbachol (CCh), KCl and caffeine of the circular smooth muscle in rat stomach were examined by the isometric tension recording method and by measurement of the intracellular Ca level, [Ca]i, with fura 2.	Carbachol	79-88	vasoactive intestinal peptide	Rattus norvegicus	15-44
1364828-2	1991	The effects of vasoactive intestinal peptide (VIP) on contractile responses to carbachol (CCh), KCl and caffeine of the circular smooth muscle in rat stomach were examined by the isometric tension recording method and by measurement of the intracellular Ca level, [Ca]i, with fura 2.	Carbachol	79-88	vasoactive intestinal peptide	Rattus norvegicus	46-49
1364828-2	1991	The effects of vasoactive intestinal peptide (VIP) on contractile responses to carbachol (CCh), KCl and caffeine of the circular smooth muscle in rat stomach were examined by the isometric tension recording method and by measurement of the intracellular Ca level, [Ca]i, with fura 2.	Carbachol	90-93	vasoactive intestinal peptide	Rattus norvegicus	15-44
1364828-2	1991	The effects of vasoactive intestinal peptide (VIP) on contractile responses to carbachol (CCh), KCl and caffeine of the circular smooth muscle in rat stomach were examined by the isometric tension recording method and by measurement of the intracellular Ca level, [Ca]i, with fura 2.	Carbachol	90-93	vasoactive intestinal peptide	Rattus norvegicus	46-49
1364828-7	1991	VIP dose-dependently inhibited the contraction induced by 1 microM CCh, but not those caused by 40 mM KCl or 3 mM caffeine.	Carbachol	67-70	vasoactive intestinal peptide	Rattus norvegicus	0-3
1364828-9	1991	In Ca-free solution containing 2 mM EGTA, VIP inhibited the phasic contraction induced by 100 microM CCh, but not that induced by 30 mM caffeine.	Carbachol	101-104	vasoactive intestinal peptide	Rattus norvegicus	42-45
1364828-15	1991	It is suggested that the inhibitory effects of VIP on CCh-induced contractions are due to the inhibition of the processes of signal transduction from muscarinic receptors to voltage-dependent Ca channels and to intracellular Ca stores.	Carbachol	54-57	vasoactive intestinal peptide	Rattus norvegicus	47-50
1886889-5	1991	Furthermore, GLP-1(7-36) amide showed additive stimulatory influence with glucose (2.8 mmol/kg), the cholinergic agonist carbachol (0.16 mumol/kg), and the C-terminal octapeptide of cholecystokinin (CCK-8, 5.3 nmol/kg), when injected at 8 or 32 nmol/kg.	Carbachol	121-130	glucagon	Mus musculus	13-18
1886889-7	1991	Moreover, the glucagon secretory responses to carbachol and CCK-8 were inhibited by GLP-1(7-36) amide but were unaffected by the entire GLP-1.	Carbachol	46-55	glucagon	Mus musculus	84-89
1704418-1	1991	The 29-amino-acid peptide galanin (GAL) caused concentration-dependent inhibition of the accumulation of 3H-inositol phosphates (3H-InsPs) induced by the muscarinic agonist carbachol (CARB; 10(-3)-10(-5) M) in the presence of 5 mM lithium, specifically in tissue miniprisms from rat ventral hippocampus.	Carbachol	173-182	galanin and GMAP prepropeptide	Rattus norvegicus	26-33
1704418-1	1991	The 29-amino-acid peptide galanin (GAL) caused concentration-dependent inhibition of the accumulation of 3H-inositol phosphates (3H-InsPs) induced by the muscarinic agonist carbachol (CARB; 10(-3)-10(-5) M) in the presence of 5 mM lithium, specifically in tissue miniprisms from rat ventral hippocampus.	Carbachol	173-182	galanin and GMAP prepropeptide	Rattus norvegicus	35-38
1704418-1	1991	The 29-amino-acid peptide galanin (GAL) caused concentration-dependent inhibition of the accumulation of 3H-inositol phosphates (3H-InsPs) induced by the muscarinic agonist carbachol (CARB; 10(-3)-10(-5) M) in the presence of 5 mM lithium, specifically in tissue miniprisms from rat ventral hippocampus.	Carbachol	184-188	galanin and GMAP prepropeptide	Rattus norvegicus	26-33
1704418-1	1991	The 29-amino-acid peptide galanin (GAL) caused concentration-dependent inhibition of the accumulation of 3H-inositol phosphates (3H-InsPs) induced by the muscarinic agonist carbachol (CARB; 10(-3)-10(-5) M) in the presence of 5 mM lithium, specifically in tissue miniprisms from rat ventral hippocampus.	Carbachol	184-188	galanin and GMAP prepropeptide	Rattus norvegicus	35-38
1704418-2	1991	The inhibitory effect of GAL involved the mono-, bis-, tris-, and tetrakisphosphates formed during activation for 2 min of phospholipase C by CARB (1 mM) in the absence of lithium.	Carbachol	142-146	galanin and GMAP prepropeptide	Rattus norvegicus	25-28
1704418-6	1991	Reduction of the extracellular Ca2+ concentration from 1.3 mM to 0.49 microM abolished the GAL inhibition of CARB-stimulated PI hydrolysis.	Carbachol	109-113	galanin and GMAP prepropeptide	Rattus norvegicus	91-94
1716879-1	1991	Both beta-adrenergic (isoproterenol) and cholinergic (carbachol) sialagogues increase amylase secretion, ornithine decarboxylase activity and DNA synthesis in murine parotid gland in vivo and in vitro.	Carbachol	54-63	ornithine decarboxylase, structural 1	Mus musculus	105-128
2055244-0	1991	Modulation of Na+, Cl- and HCO3- transport by carbachol in pig distal jejunum.	Carbachol	46-55	HCO3	Sus scrofa	27-31
2055244-9	1991	The effects of carbachol on HCO3- transport were examined by pH-stat titration.	Carbachol	15-24	HCO3	Sus scrofa	28-32
2055244-12	1991	Furthermore, the ability of carbachol to inhibit spontaneous Na+ absorption is dependent upon extracellular HCO3-.	Carbachol	28-37	HCO3	Sus scrofa	108-112
2055247-5	1991	Maximal NmU-induced contractions were 10% of the maximal contraction induced by carbachol and ranged between those of the bradykinin and angiotensin II.	Carbachol	80-89	neuromedin U	Rattus norvegicus	8-11
1987779-11	1991	Pretreatment of cells with neurotensin, carbachol, or ATP desensitized subsequent neurotensin-stimulated efflux by 82, 57, and 63%, respectively, confirming our previous results which indicated homologous and heterologous desensitization of the neurotensin receptor-signal transduction pathway.	Carbachol	40-49	neurotensin	Homo sapiens	82-93
1987779-11	1991	Pretreatment of cells with neurotensin, carbachol, or ATP desensitized subsequent neurotensin-stimulated efflux by 82, 57, and 63%, respectively, confirming our previous results which indicated homologous and heterologous desensitization of the neurotensin receptor-signal transduction pathway.	Carbachol	40-49	neurotensin	Homo sapiens	82-93
1797275-2	1991	Since stimulation of adrenergic or cholinergic receptors has no effect on glomerular filtration rate, the antidiuresis and significant delay in urinary flow observed after lateral hypothalamic stimulation with carbachol (CCh) (0.036 +/- 0.005 to 0.019 +/- 0.003 microliters min-1 100 g body weight-1) and noradrenaline (Nad) (0.024 +/- 0.005 to 0.025 +/- 0.004 microliters min-1 100 g body weight-1) are secondary to an increase in distal tubular fluid reabsorption (DFR).	Carbachol	210-219	Body weight QTL 17	Rattus norvegicus	291-299
1797275-2	1991	Since stimulation of adrenergic or cholinergic receptors has no effect on glomerular filtration rate, the antidiuresis and significant delay in urinary flow observed after lateral hypothalamic stimulation with carbachol (CCh) (0.036 +/- 0.005 to 0.019 +/- 0.003 microliters min-1 100 g body weight-1) and noradrenaline (Nad) (0.024 +/- 0.005 to 0.025 +/- 0.004 microliters min-1 100 g body weight-1) are secondary to an increase in distal tubular fluid reabsorption (DFR).	Carbachol	210-219	Body weight QTL 17	Rattus norvegicus	390-398
2003581-1	1991	The effects of carbamylcholine (carbachol) on intracellular Ca2+ concentration ([Ca2+]c) of T84 cells were examined using the fluorescent Ca2+ indicator fura-2 and microfluorometric techniques.	Carbachol	15-30	carbonic anhydrase 2	Homo sapiens	60-63
2003581-1	1991	The effects of carbamylcholine (carbachol) on intracellular Ca2+ concentration ([Ca2+]c) of T84 cells were examined using the fluorescent Ca2+ indicator fura-2 and microfluorometric techniques.	Carbachol	32-41	carbonic anhydrase 2	Homo sapiens	60-63
2003581-1	1991	The effects of carbamylcholine (carbachol) on intracellular Ca2+ concentration ([Ca2+]c) of T84 cells were examined using the fluorescent Ca2+ indicator fura-2 and microfluorometric techniques.	Carbachol	32-41	carbonic anhydrase 2	Homo sapiens	81-84
2003581-1	1991	The effects of carbamylcholine (carbachol) on intracellular Ca2+ concentration ([Ca2+]c) of T84 cells were examined using the fluorescent Ca2+ indicator fura-2 and microfluorometric techniques.	Carbachol	32-41	carbonic anhydrase 2	Homo sapiens	81-84
2003581-2	1991	In single isolated cells, carbachol (100 microM) caused a rapid increase in [Ca2+]c of 184 +/- 15 nM (SE, n = 44) from a resting value of 56 +/- 7 nM.	Carbachol	26-35	carbonic anhydrase 2	Homo sapiens	77-80
2003581-13	1991	These results show that a rise in [Ca2+]c and oscillations is likely to underlie the membrane K+ current responses to carbachol in T84 cells.	Carbachol	118-127	carbonic anhydrase 2	Homo sapiens	35-38
1902458-5	1991	After air-sham exposure, carbachol and histamine increased mean sRL to 370 +/- 40 (SE) and 309 +/- 65% of baseline, respectively.	Carbachol	25-34	sarcalumenin	Ovis aries	64-67
1902458-7	1991	Prior 30-min exposure to hyperoxia prevented the hypoxia-induced enhancement of bronchial reactivity to carbachol (sRL = 416 +/- 66% of baseline) and histamine (sRL = 292 +/- 41% of baseline) without affecting the airway responsiveness to these agents after air.	Carbachol	104-113	sarcalumenin	Ovis aries	115-118
1999473-1	1991	Carbachol, through a muscarinic receptor, thyrotropin-releasing hormone (TRH), prostaglandin F2 alpha (PGF2 alpha), bradykinin, and adenosine triphosphate (ATP) increased the apparent [Ca2+]i (intracellular free Ca2(+)-concentration) of dog thyrocytes in primary culture.	Carbachol	0-9	TRH	Canis lupus familiaris	42-71
1999473-1	1991	Carbachol, through a muscarinic receptor, thyrotropin-releasing hormone (TRH), prostaglandin F2 alpha (PGF2 alpha), bradykinin, and adenosine triphosphate (ATP) increased the apparent [Ca2+]i (intracellular free Ca2(+)-concentration) of dog thyrocytes in primary culture.	Carbachol	0-9	TRH	Canis lupus familiaris	73-76
1999473-1	1991	Carbachol, through a muscarinic receptor, thyrotropin-releasing hormone (TRH), prostaglandin F2 alpha (PGF2 alpha), bradykinin, and adenosine triphosphate (ATP) increased the apparent [Ca2+]i (intracellular free Ca2(+)-concentration) of dog thyrocytes in primary culture.	Carbachol	0-9	kininogen 1	Canis lupus familiaris	116-126
1675835-3	1991	Muscarinic receptors (carbachol-stimulated ileum) were only influenced (competitively) at 10(-7) M or above, suggesting that the non-competitive effects described above could be due to a specific reaction with the histamine H1 receptor.	Carbachol	22-31	histamine H1 receptor	Cavia porcellus	214-235
12106186-1	1991	Single electrode current clamp and voltage clamp recordings were employed to study the effects of noradrenergic agonists and a cholinergic agonist (carbachol, Cch) on the resting membrane potential of CA3 neurons in guinea pig hippocampal slices.	Carbachol	148-157	carbonic anhydrase 3	Cavia porcellus	201-204
1716879-4	1991	Isoproterenol-dependent ornithine decarboxylase induction and phosphorylation of the proteins were selectively suppressed by monensin but not by polymyxin B, whereas carbachol-dependent ornithine decarboxylase induction and protein phosphorylation were inhibited by polymyxin B but not by monensin.	Carbachol	166-175	ornithine decarboxylase 1	Rattus norvegicus	186-209
1716879-7	1991	Propranolol and atropine, antagonists of isoproterenol and carbachol, respectively, completely inhibited not only amylase secretion and ornithine decarboxylase induction but also protein phosphorylation stimulated by the corresponding agonists.	Carbachol	59-68	ornithine decarboxylase 1	Rattus norvegicus	136-159
1988650-0	1991	Protein kinase C translocation in rat stomach fundus: effects of serotonin, carbamylcholine and phorbol dibutyrate.	Carbachol	76-91	protein kinase C, gamma	Rattus norvegicus	0-16
2050284-6	1991	We found that Ca reversal was observed in the smooth muscle of rat thoracic aorta contracted by norepinephrine or by a phorbol ester, TPA, guinea pig tracheal smooth muscle contracted to carbachol, fundic smooth muscle of rat stomach to carbachol, corporal and antral smooth muscle of guinea pig stomach to carbachol and rat vas deferens to norepinephrine.	Carbachol	187-196	plasminogen activator, tissue type	Rattus norvegicus	134-137
1988650-8	1991	However, PDBu (10 nM-1 microM) and carbamylcholine (0.1-10 microM) significantly increased membrane-bound PKC activity.	Carbachol	35-50	protein kinase C, gamma	Rattus norvegicus	106-109
1988650-9	1991	These results: 1) demonstrate that translocation of PKC occurred in rat stomach fundus in response to some, but not all, contractile agonists; 2) are consistent with the possibility that contraction of rat stomach fundus by carbamylcholine and PDBu may be related to increased membrane-bound PKC activity; and 3) indicate that serotonin-induced contraction, although potently blocked by staurosporine, did not result from PKC translocation in the rat stomach fundus.	Carbachol	224-239	protein kinase C, gamma	Rattus norvegicus	52-55
1988650-9	1991	These results: 1) demonstrate that translocation of PKC occurred in rat stomach fundus in response to some, but not all, contractile agonists; 2) are consistent with the possibility that contraction of rat stomach fundus by carbamylcholine and PDBu may be related to increased membrane-bound PKC activity; and 3) indicate that serotonin-induced contraction, although potently blocked by staurosporine, did not result from PKC translocation in the rat stomach fundus.	Carbachol	224-239	protein kinase C, gamma	Rattus norvegicus	292-295
1988650-9	1991	These results: 1) demonstrate that translocation of PKC occurred in rat stomach fundus in response to some, but not all, contractile agonists; 2) are consistent with the possibility that contraction of rat stomach fundus by carbamylcholine and PDBu may be related to increased membrane-bound PKC activity; and 3) indicate that serotonin-induced contraction, although potently blocked by staurosporine, did not result from PKC translocation in the rat stomach fundus.	Carbachol	224-239	protein kinase C, gamma	Rattus norvegicus	292-295
1825686-3	1991	Carbachol stimulated the rate of inositol phospholipid breakdown in IMR-32 and SK-N-MC human neuroblastoma cells with an EC50 value of about 50 microM in both cases.	Carbachol	0-9	hedgehog acyltransferase	Homo sapiens	79-83
1825686-4	1991	Pirenzepine inhibited the carbachol (100 microM)-stimulated inositol phospholipid breakdown in both cells with Hill slopes of unity and IC50 values of 15 nM (IMR-32) and 12 nM (SK-N-MC).	Carbachol	26-35	hedgehog acyltransferase	Homo sapiens	177-181
1646361-6	1991	Bovine adrenal glands stimulated with 100 microM carbachol released 0.47 +/- 0.12 nmol/gland of Ap4A and 1.11 +/- 0.26 nmol/gland of Ap5A.	Carbachol	49-58	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	96-106
1825686-5	1991	The 5-HT1A receptor agonist 8-OH-DPAT competitively inhibited carbachol-stimulated inositol phospholipid breakdown with pA2 values of 5.78 (IMR-32) and 5.61 (SK-N-MC).	Carbachol	62-71	5-hydroxytryptamine receptor 1A	Homo sapiens	4-19
1825686-5	1991	The 5-HT1A receptor agonist 8-OH-DPAT competitively inhibited carbachol-stimulated inositol phospholipid breakdown with pA2 values of 5.78 (IMR-32) and 5.61 (SK-N-MC).	Carbachol	62-71	hedgehog acyltransferase	Homo sapiens	158-162
1646447-4	1991	In contrast to the results obtained with the binding experiments using antagonists, the study of the cellular cyclic nucleotide response upon carbachol stimulation suggested the presence of both the M1 and M2 subtypes as there was an increase in cyclic GMP concentration while at the same time, the prostaglandin-stimulated synthesis of cyclic AMP was inhibited.	Carbachol	142-151	5'-nucleotidase, cytosolic II	Mus musculus	253-256
2176212-6	1990	Treatment of 1321N1 cells with carbachol results in increases in radiolabeled choline, phosphatidic acid (PA) and phosphatidylethanol (PEt), metabolites that are products of phospholipase D (PLD) action on PC.	Carbachol	31-40	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	174-189
2176212-6	1990	Treatment of 1321N1 cells with carbachol results in increases in radiolabeled choline, phosphatidic acid (PA) and phosphatidylethanol (PEt), metabolites that are products of phospholipase D (PLD) action on PC.	Carbachol	31-40	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	191-194
2176212-9	1990	It appears that most of the DG is formed through the action of PLD, since propranolol (which inhibits the conversion of PA to DG) and down-regulation of protein kinase C (which prevents activation of PLD by carbachol) both markedly inhibit DG production.	Carbachol	207-216	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	63-66
2176212-9	1990	It appears that most of the DG is formed through the action of PLD, since propranolol (which inhibits the conversion of PA to DG) and down-regulation of protein kinase C (which prevents activation of PLD by carbachol) both markedly inhibit DG production.	Carbachol	207-216	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	200-203
2176212-10	1990	Using a protocol in which cells are stimulated with carbachol for only one minute (a period during which PLD and PA formation are maximally activated), we show that DG mass continues to increase following removal of agonist.	Carbachol	52-61	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	105-108
2176213-6	1990	Surprisingly, however, carbachol is not a mitogen for 39M1-81 cells, and even if tested in association with insulin or fibroblast growth factor, its effects on cell proliferation remained weak when compared with thrombin.	Carbachol	23-32	insulin	Cricetulus griseus	108-115
2260641-0	1990	VIP and forskolin enhance carbachol-induced K+ efflux from rat salivary gland fragments by a Ca2(+)-sensitive mechanism.	Carbachol	26-35	vasoactive intestinal peptide	Rattus norvegicus	0-3
2293110-2	1990	Encouraged by the finding that microinjections of the cholinergic agonist carbachol into the medial pontine reticular formation (mPRF) of the cat produced respiratory changes paralleling those observed during rapid eye movement (REM) sleep (Neurosci.	Carbachol	74-83	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	129-133
2260641-1	1990	The effect of vasoactive intestinal peptide (VIP) and forskolin on carbachol-induced K+ release from superfused rat submandibular and parotid gland fragments was examined using a K(+)-sensitive electrode.	Carbachol	67-76	vasoactive intestinal peptide	Rattus norvegicus	14-43
2260641-1	1990	The effect of vasoactive intestinal peptide (VIP) and forskolin on carbachol-induced K+ release from superfused rat submandibular and parotid gland fragments was examined using a K(+)-sensitive electrode.	Carbachol	67-76	vasoactive intestinal peptide	Rattus norvegicus	45-48
2260641-4	1990	VIP (1 microM) lacked effect on K+ efflux on its own but increased the carbachol (1 microM)-evoked K+ release.	Carbachol	71-80	vasoactive intestinal peptide	Rattus norvegicus	0-3
2260641-6	1990	Omission of Ca2+ from the medium totally abolished the augmenting effect of VIP and forskolin on carbachol-evoked K+ efflux.	Carbachol	97-106	vasoactive intestinal peptide	Rattus norvegicus	76-79
2260641-10	1990	It is concluded that VIP, by increasing the intracellular levels of cAMP in the glandular cell, potentiates carbachol-evoked Ca2(+)-dependent K+ efflux.	Carbachol	108-117	vasoactive intestinal peptide	Rattus norvegicus	21-24
2124620-5	1990	Carbachol stimulated the release of [3H]lysophosphatidylcholine from [3H]choline prelabeled cells, suggesting that phospholipase A2 was involved in the release of arachidonic acid.	Carbachol	0-9	phospholipase A2	Cricetulus griseus	115-131
1707744-1	1990	The outward current evoked in CA1 neurons by brief anoxia is strongly voltage dependent and is abolished by an atropine-sensitive action of carbachol (and also when recording with a GTP gamma S-containing microelectrode).	Carbachol	140-149	carbonic anhydrase 1	Homo sapiens	30-33
1707744-4	1990	It is suggested that an early release of Ca2+ from a dantrolene (and perhaps GTP)-sensitive internal store activates Ca-sensitive Cl channels, as well as carbachol-sensitive (mainly M-type?)	Carbachol	154-163	carbonic anhydrase 2	Homo sapiens	41-44
2174803-7	1990	In the present report we demonstrate that the acetylcholine analog carbachol enhanced toxin-stimulated cyclic GMP accumulation in intact T84 cells by 50-100% and that this effect was blocked by 10 microM atropine and 10 microM sphingosine.	Carbachol	67-76	5'-nucleotidase, cytosolic II	Homo sapiens	110-113
2174803-0	1990	Carbachol mimics phorbol esters in its ability to enhance cyclic GMP production by STa, the heat-stable toxin of Escherichia coli.	Carbachol	0-9	5'-nucleotidase, cytosolic II	Homo sapiens	65-68
2174803-9	1990	Carbachol, which elevates intracellular calcium in these cells, may act through protein kinase C to enhance cyclic GMP production.	Carbachol	0-9	5'-nucleotidase, cytosolic II	Homo sapiens	115-118
1981603-8	1990	Sympathomimetic beta adrenergic agonists relaxed carbachol-precontracted tracheas with the following order of potency: isoprenaline (beta 1 and beta 2 adrenoceptor agonist) greater than salbutamol (beta 2 adrenoceptor agonist) greater than prenalterol (beta 1 adrenoceptor agonist).	Carbachol	49-58	adrenergic receptor, beta 1	Mus musculus	133-163
1981603-8	1990	Sympathomimetic beta adrenergic agonists relaxed carbachol-precontracted tracheas with the following order of potency: isoprenaline (beta 1 and beta 2 adrenoceptor agonist) greater than salbutamol (beta 2 adrenoceptor agonist) greater than prenalterol (beta 1 adrenoceptor agonist).	Carbachol	49-58	adrenergic receptor, beta 2	Mus musculus	144-163
1981603-8	1990	Sympathomimetic beta adrenergic agonists relaxed carbachol-precontracted tracheas with the following order of potency: isoprenaline (beta 1 and beta 2 adrenoceptor agonist) greater than salbutamol (beta 2 adrenoceptor agonist) greater than prenalterol (beta 1 adrenoceptor agonist).	Carbachol	49-58	adrenergic receptor, beta 1	Mus musculus	253-272
2074719-4	1990	Output of both pH and HCO3- in these tissues was significantly increased by intravenous administration of prostaglandin (PGE2), 16, 16-dimethyl PGE2, carbachol, and YM-14673 (a thyrotropin-releasing hormone (TRH) analog), whereas the PD responded to these agents by a significant rise in the duodenum and decrease in the stomach.	Carbachol	150-159	thyrotropin releasing hormone	Rattus norvegicus	177-206
1702343-0	1990	Spinal cord substance P mediates carbachol-induced cardiovascular responses from the rostral ventrolateral medulla.	Carbachol	33-42	tachykinin precursor 1	Homo sapiens	12-23
1701910-6	1990	An initial stimulation of cells with a high dose of CCK eliminated the Ca2+i response to further stimulation with CCK, carbachol, bombesin and SP, whereas cells subjected to initial stimulation with SP responded to subsequent exposure to CCK with prolonged elevation of Ca2+i.	Carbachol	119-128	cholecystokinin	Homo sapiens	52-55
2257432-23	1990	A 1 microM concentration of either fragment was equivalent in effect to 30nm NPY upon basal current, but NPY at this concentration significantly reduced both CCh- and SP-induced secretion.	Carbachol	158-161	neuropeptide Y	Rattus norvegicus	105-108
1700270-3	1990	The effects of carbachol on forskolin-stimulated cAMP levels were further augmented approximately 10-fold in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (MIX) but not in the presence of "low Km" cGMP-inhibited phosphodiesterase inhibitor milrinone.	Carbachol	15-24	phosphodiesterase 3A, cGMP inhibited	Mus musculus	227-259
1700270-8	1990	Cyclic GMP levels were also enhanced by carbachol plus isoproterenol.	Carbachol	40-49	5'-nucleotidase, cytosolic II	Mus musculus	7-10
2226784-2	1990	Carbachol induced an increase in intracellular Ca2+ and stimulated gastrin release in a dose-dependent manner over the range 10(-5)-10(-3) M. These effects were completely abolished by atropine, suggesting the implication of muscarinic cholinergic receptors.	Carbachol	0-9	gastrin	Rattus norvegicus	67-74
2226784-7	1990	These results suggest the M3 muscarinic receptors may be involved in the carbachol-induced gastrin release from B6 RIN cells.	Carbachol	73-82	gastrin	Rattus norvegicus	91-98
2167677-2	1990	After a 45-min incubation at 37 degrees of N1E-115 cells either in monolayer or in suspension, with the muscarinic agonist carbachol (1 mM), the receptor-mediated cyclic GMP response to carbachol was nearly completely lost.	Carbachol	123-132	5'-nucleotidase, cytosolic II	Mus musculus	170-173
2167677-2	1990	After a 45-min incubation at 37 degrees of N1E-115 cells either in monolayer or in suspension, with the muscarinic agonist carbachol (1 mM), the receptor-mediated cyclic GMP response to carbachol was nearly completely lost.	Carbachol	186-195	5'-nucleotidase, cytosolic II	Mus musculus	170-173
2282459-5	1990	In contrast, CGRP sometimes reduced spontaneous or carbamylcholine-induced tone of lung parenchymal strips.	Carbachol	51-66	calcitonin-related polypeptide alpha	Rattus norvegicus	13-17
2282459-7	1990	CGRP produced a significant rightward shift of the log concentration-response curves to carbamylcholine and 5-hydroxytryptamine (5-HT) in the main bronchus.	Carbachol	88-103	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
2282459-11	1990	In all three airway preparations, CGRP caused concentration-dependent inhibition of responses elicited by challenges with 10(-7) M carbamylcholine or 5 x 10(-7) M 5-HT.	Carbachol	131-146	calcitonin-related polypeptide alpha	Rattus norvegicus	34-38
2381568-9	1990	carbachol injection were reduced 1-2 days after AV3V lesion (delta MAP = 6 +/- 2 mmHg, water ingestion = 0.3 +/- 0.3 ml/h and Na+ excretion = 31 +/- 11 microEq/120 min) and 9-12 days (delta MAP = 11 +/- 3 mmHg, water ingestion = 3.3 +/- 0.9 ml/h and Na+ excretion = 37 +/- 11 microEq/120 min).	Carbachol	0-9	microtubule-associated protein 6	Rattus norvegicus	67-74
2168484-9	1990	On the nACh-R, spermine, spermidine and agmatine inhibited [125I]alpha-bungarotoxin and also [3H]H12-HTX binding in presence of carbamylcholine.	Carbachol	128-143	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	7-13
1706667-6	1990	SS-14 also attenuated secretory responses produced by carbachol, substance P (SP), VIP and alpha- and beta-calcitonin gene related peptide (alpha-, beta-CGRP).	Carbachol	54-63	somatostatin	Rattus norvegicus	0-5
2166590-0	1990	Activation of phospholipase C in rabbit brain membranes by carbachol in the presence of GTP gamma S; effects of biological detergents.	Carbachol	59-68	LOC100009319	Oryctolagus cuniculus	14-29
2166590-4	1990	Optimal activation of phospholipase C by carbachol was seen at 10 to 100 nM free Ca2+.	Carbachol	41-50	LOC100009319	Oryctolagus cuniculus	22-37
1980640-5	1990	Somatostatin inhibited carbachol- and cholecystokinin octapeptide-induced pepsinogen secretion from dispersed gastric mucosal cells in a dose-dependent manner.	Carbachol	23-32	somatostatin	Rattus norvegicus	0-12
2162335-2	1990	In all three tissue preparations, the cholinergic agonist carbamylcholine markedly inhibited the stimulation of cAMP biosynthesis by vasoactive intestinal peptide VIP--a potent activator of nonpigmented ciliary epithelial adenylate cyclase.	Carbachol	58-73	VIP peptides	Oryctolagus cuniculus	163-166
2162335-4	1990	The effects of carbamylcholine on VIP-induced cAMP synthesis were concentration dependent (EC50 = 23 nM), mimicked by selective muscarinic cholinergic agonists (oxotremorine, pilocarpine), and antagonized by atropine.	Carbachol	15-30	VIP peptides	Oryctolagus cuniculus	34-37
2162335-5	1990	Carbamylcholine- and clonidine-mediated inhibition of VIP-stimulated cAMP accumulation in ciliary processes were nonadditive, indicating that inhibitory muscarinic and alpha 2-adrenergic receptors coexist on VIP-responsive target cells.	Carbachol	0-15	VIP peptides	Oryctolagus cuniculus	54-57
2162335-5	1990	Carbamylcholine- and clonidine-mediated inhibition of VIP-stimulated cAMP accumulation in ciliary processes were nonadditive, indicating that inhibitory muscarinic and alpha 2-adrenergic receptors coexist on VIP-responsive target cells.	Carbachol	0-15	VIP peptides	Oryctolagus cuniculus	208-211
1976755-6	1990	Pretreatment of cells with a lower concentration of MTX (0.3 ng/ml) also attenuated carbachol- and glutamate-induced IP formation, in a time-dependent manner, with a decrease observed after 30 min prestimulation, but failed to affect NE-, histamine-, 5-HT-, endothelin-1, and sarafotoxin S6b-induced responses.	Carbachol	84-93	endothelin 1	Rattus norvegicus	258-270
2117049-6	1990	Quinacrine, a nonselective phospholipase A2 inhibitor, reduced the carbachol stimulation of adenylate cyclase activity, but this inhibition appeared to be competitive with a Ki of 0.2 microM.	Carbachol	67-76	phospholipase A2 group IB	Rattus norvegicus	27-43
2146244-1	1990	The purpose of this study was to measure airway and hemodynamic effects of atrial natriuretic peptide (ANP) and its efficacy in counteracting the changes in lung mechanics that occur with aerosol histamine and carbachol.	Carbachol	210-219	natriuretic peptides A	Ovis aries	75-101
2146244-1	1990	The purpose of this study was to measure airway and hemodynamic effects of atrial natriuretic peptide (ANP) and its efficacy in counteracting the changes in lung mechanics that occur with aerosol histamine and carbachol.	Carbachol	210-219	natriuretic peptides A	Ovis aries	103-106
2146244-5	1990	ANP was given as bolus injections of 1, 5, and 10 micrograms/kg 3 min after either the ED65Cdyn or ED200RL doses of histamine and carbachol, respectively, and the airway response was monitored for 10 min.	Carbachol	130-139	natriuretic peptides A	Ovis aries	0-3
2146244-6	1990	ANP significantly reversed the rise in RL after carbachol administration (n = 10).	Carbachol	48-57	natriuretic peptides A	Ovis aries	0-3
2165399-5	1990	Incubation with carbachol for 15 min caused a small increase of membrane-associated PK-C activity (15% increase, P less than 0.05) as compared with the potency of phorbol esters (PMA) (3-4-fold increase, P less than 0.01).	Carbachol	16-25	proline rich transmembrane protein 2	Homo sapiens	84-88
2359403-2	1990	Upon incubation of the cells with the full agonist carbachol, a 4.5- to 5-fold increase in CaM in the cytosol was observed, from 126 ng of CaM to 629 ng of CaM.	Carbachol	51-60	calmodulin 1	Homo sapiens	91-94
2238765-8	1990	Prior exposure of the pancrease to carbachol enhanced the glucose / GLP-1 (7-36)amide induced insulin release, but left the arginine stimulated secretion unaltered.	Carbachol	35-44	glucagon	Rattus norvegicus	68-73
2359403-2	1990	Upon incubation of the cells with the full agonist carbachol, a 4.5- to 5-fold increase in CaM in the cytosol was observed, from 126 ng of CaM to 629 ng of CaM.	Carbachol	51-60	calmodulin 1	Homo sapiens	139-142
2359403-2	1990	Upon incubation of the cells with the full agonist carbachol, a 4.5- to 5-fold increase in CaM in the cytosol was observed, from 126 ng of CaM to 629 ng of CaM.	Carbachol	51-60	calmodulin 1	Homo sapiens	139-142
2359403-7	1990	The maximal changes in CaM concentration in both membranes and cytosol occurred with 10 microM carbachol.	Carbachol	95-104	calmodulin 1	Homo sapiens	23-26
2399112-2	1990	High K+ and carbachol induced a sustained increase in [Ca2+]cyt and muscle tension.	Carbachol	12-21	carbonic anhydrase 2	Canis lupus familiaris	55-58
2399112-4	1990	Cumulative addition of carbachol induced greater contraction than high K+ at a given [Ca2+]cyt 12-Deoxyphorbol 13-isobutyrate (DPB) (50 nmol/l) induced a small sustained contraction with little effect on [Ca2+]cyt.	Carbachol	23-32	carbonic anhydrase 2	Canis lupus familiaris	86-89
2399112-4	1990	Cumulative addition of carbachol induced greater contraction than high K+ at a given [Ca2+]cyt 12-Deoxyphorbol 13-isobutyrate (DPB) (50 nmol/l) induced a small sustained contraction with little effect on [Ca2+]cyt.	Carbachol	23-32	carbonic anhydrase 2	Canis lupus familiaris	205-208
2399112-8	1990	Addition of 50 nmol/l or 1 mumol/l DPB in the presence of carbachol inhibited both [Ca2+]cyt and muscle tension.	Carbachol	58-67	carbonic anhydrase 2	Canis lupus familiaris	84-87
2399112-10	1990	Verapamil inhibited the contraction and [Ca2+]cyt stimulated by high K+ and carbachol.	Carbachol	76-85	carbonic anhydrase 2	Canis lupus familiaris	41-44
2399112-11	1990	Isoprenaline and forskolin inhibited the high-K(+)-induced contraction without changing [Ca2+]cyt, whereas these inhibitors inhibited carbachol-induced contraction with a relatively small decrease in [Ca2+]cyt.	Carbachol	134-143	carbonic anhydrase 2	Canis lupus familiaris	201-204
2399112-12	1990	These results suggest that (a) sustained contractions induced by high K+ and carbachol are due to the sustained increase in [Ca2+]cyt, (b) carbachol increases the sensitivity of contractile elements to Ca2+, and (c) isoprenaline and forskolin inhibit the contraction by the decrease in [Ca2+]cyt and also by the decrease in the sensitivity of contractile elements to Ca2+.	Carbachol	77-86	carbonic anhydrase 2	Canis lupus familiaris	125-128
2399112-12	1990	These results suggest that (a) sustained contractions induced by high K+ and carbachol are due to the sustained increase in [Ca2+]cyt, (b) carbachol increases the sensitivity of contractile elements to Ca2+, and (c) isoprenaline and forskolin inhibit the contraction by the decrease in [Ca2+]cyt and also by the decrease in the sensitivity of contractile elements to Ca2+.	Carbachol	139-148	carbonic anhydrase 2	Canis lupus familiaris	125-128
2399112-12	1990	These results suggest that (a) sustained contractions induced by high K+ and carbachol are due to the sustained increase in [Ca2+]cyt, (b) carbachol increases the sensitivity of contractile elements to Ca2+, and (c) isoprenaline and forskolin inhibit the contraction by the decrease in [Ca2+]cyt and also by the decrease in the sensitivity of contractile elements to Ca2+.	Carbachol	139-148	carbonic anhydrase 2	Canis lupus familiaris	202-205
2399112-12	1990	These results suggest that (a) sustained contractions induced by high K+ and carbachol are due to the sustained increase in [Ca2+]cyt, (b) carbachol increases the sensitivity of contractile elements to Ca2+, and (c) isoprenaline and forskolin inhibit the contraction by the decrease in [Ca2+]cyt and also by the decrease in the sensitivity of contractile elements to Ca2+.	Carbachol	139-148	carbonic anhydrase 2	Canis lupus familiaris	202-205
2399112-12	1990	These results suggest that (a) sustained contractions induced by high K+ and carbachol are due to the sustained increase in [Ca2+]cyt, (b) carbachol increases the sensitivity of contractile elements to Ca2+, and (c) isoprenaline and forskolin inhibit the contraction by the decrease in [Ca2+]cyt and also by the decrease in the sensitivity of contractile elements to Ca2+.	Carbachol	139-148	carbonic anhydrase 2	Canis lupus familiaris	202-205
2359403-9	1990	Thus, the partial agonists were less efficacious than carbachol in eliciting changes in CaM localization.	Carbachol	54-63	calmodulin 1	Homo sapiens	88-91
2162060-7	1990	The carbachol inhibitory effect occurred under conditions that prevented activation of phospholipase A2, excluding a role of the arachidonic acid metabolism in this process.	Carbachol	4-13	phospholipase A2 group IB	Rattus norvegicus	87-103
2167230-5	1990	In contrast, neuraminidase or virus decreased the affinity of carbachol for both sites in the heart.	Carbachol	62-71	neuraminidase 1	Homo sapiens	13-26
2167230-6	1990	The neuraminidase inhibitor completely blocked virus-induced changes in carbachol affinity in both tissues.	Carbachol	72-81	neuraminidase 1	Homo sapiens	4-17
2194793-4	1990	The transformed line secretes an apparently fully active enzyme and responds to carbachol stimulation with a rapid release of renin activity.	Carbachol	80-89	renin	Rattus norvegicus	126-131
1693390-5	1990	Carbachol-induced dopamine release was inhibited by substance P and by neuropeptide Y.	Carbachol	0-9	tachykinin precursor 1	Bos taurus	52-63
2324742-7	1990	Under similar conditions, 0.5 mM carbachol stimulated the production of DG to the same extent as 200 ng/ml NGF and 50 ng/ml bFGF.	Carbachol	33-42	nerve growth factor	Rattus norvegicus	107-110
2324742-7	1990	Under similar conditions, 0.5 mM carbachol stimulated the production of DG to the same extent as 200 ng/ml NGF and 50 ng/ml bFGF.	Carbachol	33-42	fibroblast growth factor 2	Rattus norvegicus	124-128
2324742-8	1990	Because carbachol is much more effective in stimulating the production of inositol phosphates, the results suggest that both NGF and bFGF stimulate the production of DG primarily from phospholipids other than the phosphoinositides.	Carbachol	8-17	nerve growth factor	Rattus norvegicus	125-128
1696375-2	1990	GAL-induced contractions (GAL EC50 = 9 nmol/l) were maximally 25% of those elicited by 10 mumol/l carbamylcholine and remained unaffected by atropine, tetrodotoxin, or tachyphylaxis to substance P. The presynaptic Ca2+ channel blocker, omega-conotoxin (0.1 mumol/l), inhibited GAL-induced contractions by 66%.	Carbachol	98-113	galanin and GMAP prepropeptide	Homo sapiens	0-3
2159581-5	1990	When nicotinic acetylcholine receptor was eluted with either carbachol or nicotine from the affinity column, these major bands were found on SDS-PAGE gels.	Carbachol	61-70	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	5-37
2162944-7	1990	Incubation with carbachol, ATP or phorbol 12-myristate, 13-acetate desensitized the subsequent [Ca2+]i response to neurotensin.	Carbachol	16-25	neurotensin	Homo sapiens	115-126
1692606-3	1990	Neuraminidase decreased the affinity of the M2-selective agonist carbamylcholine in competitive binding experiments performed with [3H]QNB and [3H]NMS.	Carbachol	65-80	neuraminidase 1	Homo sapiens	0-13
2110452-7	1990	Whereas VIP is reported to stimulate chloride secretion more strongly than carbachol, it was less effective than carbachol in stimulating mucin secretion.	Carbachol	113-122	LOC100508689	Homo sapiens	138-143
1692187-2	1990	In this fraction, basal gastrin release (mean +/- SE) was 31.1 +/- 1.3 pg.10(6) cells-1.60 min-1 and was stimulated by 10(-8) M neuromedin C (222.3 +/- 18.1% of basal), 10(-4) M carbachol (227.5 +/- 25.9%), 10(-6) M 12-O-tetradecanoylphorbol-13-acetate (TPA) (196.3 +/- 14.7%), and 10(-3) M dibutyryl adenosine 3",5"-cyclic monophosphate (DBcAMP) (193.9 +/- 6.8%), respectively.	Carbachol	178-187	gastrin	Rattus norvegicus	24-31
1693390-5	1990	Carbachol-induced dopamine release was inhibited by substance P and by neuropeptide Y.	Carbachol	0-9	neuropeptide Y	Bos taurus	71-85
2352839-1	1990	The effects of K+ depolarization and of the muscarinic agonist carbachol on [Ca2+]i and force were investigated in smooth muscle sheets of the longitudinal layer of the ileum loaded with Fura-2.	Carbachol	63-72	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	77-80
2352839-6	1990	The stimulation with 0.1 mM carbachol resulted in a transient increase of [Ca2+]i and force followed by a continuous decline of these parameters despite the presence of the drug.	Carbachol	28-37	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	75-78
2352839-10	1990	These results suggest that (a) both agonists increase force and [Ca2+]i during stimulation; (b) during depolarization with K+, desensitization to CA2+ occurs resulting in a clockwise hysteresis loop; (c) during carbachol stimulation, a counterclockwise hysteresis is observed.	Carbachol	211-220	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	146-149
2155219-9	1990	The calmodulin inhibitors trifluoperazine and W7 (10(-4) M) prevented the stimulation of the exchanger induced by carbachol or epinephrine, but W7 could not block the stimulation produced by A23187 arguing against the involvement of calmodulin in this effect.	Carbachol	114-123	calmodulin 1	Rattus norvegicus	4-14
2307120-8	1990	Vascular bombesin (10(-7) M) and carbachol (10(-5) M) provoked a biphasic release of NT, consisting of a transient rise (approximately 600% above basal) followed by a less pronounced but sustained response.	Carbachol	33-42	neurotensin	Rattus norvegicus	85-87
2156987-2	1990	The pD2 value of BK on the longitudinal muscle was 6.58 +/- 0.06 M. The maximal response of the longitudinal muscle to BK was 44% compared to carbachol.	Carbachol	142-151	kininogen 1	Homo sapiens	17-19
1968059-4	1990	Moreover, somatostatin significantly inhibited gene transcription that had been stimulated by dibutyryl-cAMP and carbachol.	Carbachol	113-122	somatostatin	Canis lupus familiaris	10-22
1689544-3	1990	Stimulation with the cholinergic agonist carbachol (1 microM) resulted in a rapid increase in [Ca2+]i to 308 +/- 26 nM, which was sustained at a nearly constant elevated level (328 +/- 31 nM) throughout agonist application.	Carbachol	41-50	carbonic anhydrase 2	Homo sapiens	95-98
2157926-5	1990	Thus, the main features of AD are a cAarP response to Met-enk and an abolition of a GarP response to carbachol.	Carbachol	101-110	leucine rich repeat containing 32	Homo sapiens	84-88
2156444-2	1990	EGF effects on histamine- and carbachol-stimulated [14C]aminopyrine (AP) uptake and intrinsic factor (IF) secretion were evaluated in isolated rabbit parietal cells.	Carbachol	30-39	pro-epidermal growth factor	Oryctolagus cuniculus	0-3
2156444-6	1990	EGF inhibited carbachol-stimulated [14C]AP uptake and IF secretion, but did not alter the carbachol-stimulated Ca2+ transient.	Carbachol	14-23	pro-epidermal growth factor	Oryctolagus cuniculus	0-3
2156444-7	1990	These results indicate that EGF inhibits histamine-stimulated secretion through the inhibitory Gi guanosine 5"-triphosphate-binding protein and carbachol-stimulated secretion through a mechanism independent of the activation of an increase in intracellular Ca2+.	Carbachol	144-153	pro-epidermal growth factor	Oryctolagus cuniculus	28-31
2106265-3	1990	When membrane potential was clamped to 0 mV, carbachol induced an outwardly directed K+ current in 31 of 37 cells, with a peak value of 618 +/- 51 (SE) pA.	Carbachol	45-54	extra spindle pole bodies like 1, separase	Homo sapiens	148-154
2156059-4	1990	Prolonged incubation of SK-N-SH cells with the partial agonist bethanechol also resulted in a desensitization of stimulated PPI turnover but at a slower rate than that observed for carbachol and with a loss of fewer mAChR sites.	Carbachol	181-190	hedgehog acyltransferase	Homo sapiens	24-28
2304648-2	1990	Intracellular recordings from CA1 pyramidal neurones revealed that CCh (1-3 microM) inhibited excitatory postsynaptic responses evoked by stimulation of the Schaffer collateral/commissural pathway while, at the same time, direct excitability was enhanced.	Carbachol	67-70	carbonic anhydrase 1	Rattus norvegicus	30-33
2304648-3	1990	Extracellularly, CCh produced a concentration-dependent reduction of the amplitude of the field excitatory postsynaptic potential (field EPSP) recorded in the CA1 apical dendritic region.	Carbachol	17-20	carbonic anhydrase 1	Rattus norvegicus	159-162
2304648-5	1990	These results confirm earlier reports of a presynaptic inhibitory action of CCh in the hippocampal CA1 region and provide strong evidence that this effect is mediated by muscarinic receptors of the M1 subtype.	Carbachol	76-79	carbonic anhydrase 1	Rattus norvegicus	99-102
2302186-2	1990	Carbachol stimulation leads to a rapid increase in intracellular Ca2+ and Ins(1,4,5)P3 mass, both reaching a peak at around 10 s and then declining to a new maintained phase significantly above basal.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	65-68
2302186-3	1990	Dose-response analysis of peak and plateau phases of intracellular Ca2+ shows different agonist potencies for both phases, carbachol being more potent for the plateau phase.	Carbachol	123-132	carbonic anhydrase 2	Homo sapiens	67-70
2153579-3	1990	The inhibitory effect of mastoparan on carbachol-induced [3H]inositol phosphate accumulation was resistant to pertussis toxin (IAP) treatment in intact cells.	Carbachol	39-48	alkaline phosphatase, intestinal	Homo sapiens	127-130
1689117-1	1990	First incubating guinea pig pancreatic acini with carbachol reduced the subsequent stimulation of amylase release caused by carbachol, cholecystokinin octapeptide (CCK-8), and bombesin but not that caused by vasoactive intestinal peptide, substance P, 8-bromoadenosine 3",5"-cyclic monophosphate, A23187, or 12-O-tetradecanoylphorbol-13-acetate.	Carbachol	50-59	cholecystokinin	Cavia porcellus	164-167
1689117-2	1990	Carbachol also reduced the subsequent binding of N-[3H]methylscopolamine, 125I-CCK-8, and 125I-[Tyr4]bombesin.	Carbachol	0-9	cholecystokinin	Cavia porcellus	79-82
1689117-5	1990	Carbachol occupation of low-affinity cholinergic receptors appears to produce the reduction in CCK-8- and bombesin-stimulated amylase release and in binding of 125I-CCK-8 and 125I-[Tyr4]bombesin.	Carbachol	0-9	cholecystokinin	Cavia porcellus	95-98
1689117-5	1990	Carbachol occupation of low-affinity cholinergic receptors appears to produce the reduction in CCK-8- and bombesin-stimulated amylase release and in binding of 125I-CCK-8 and 125I-[Tyr4]bombesin.	Carbachol	0-9	cholecystokinin	Cavia porcellus	165-168
1689117-8	1990	First incubating acini with carbachol caused a 60% decrease in the number of high-affinity CCK receptors with no change in the number of low-affinity receptors or the affinities of either class of receptors for CCK-8.	Carbachol	28-37	cholecystokinin	Cavia porcellus	91-94
1689117-10	1990	12-O-tetradecanoyl phorbol-13-acetate reproduced the action of carbachol on binding of N-[3H]methylscopolamine and 125I-CCK-8 but not on binding of 125I-[Tyr4]bombesin, suggesting that carbachol activation of protein kinase C may in some way mediate the effect of carbachol on receptors for carbachol and those for CCK but not that on receptors for bombesin.	Carbachol	63-72	cholecystokinin	Cavia porcellus	120-123
1689117-10	1990	12-O-tetradecanoyl phorbol-13-acetate reproduced the action of carbachol on binding of N-[3H]methylscopolamine and 125I-CCK-8 but not on binding of 125I-[Tyr4]bombesin, suggesting that carbachol activation of protein kinase C may in some way mediate the effect of carbachol on receptors for carbachol and those for CCK but not that on receptors for bombesin.	Carbachol	63-72	cholecystokinin	Cavia porcellus	315-318
2269025-18	1990	LHRH can have a modulatory role upon the action of 5-HT, DA and Carb, and estrogen pretreatment specifically affects that of DA in the SCN.	Carbachol	64-68	gonadotropin releasing hormone 1	Rattus norvegicus	0-4
2400633-7	1990	In conclusion, phospholipase C activation, intracellular Ca2+ release and aminopyrine accumulation were sequentially observed following carbachol stimulation of the isolated gastric parietal cell and extracellular calcium contributed to sustain this acid secretory response.	Carbachol	136-145	LOC100009319	Oryctolagus cuniculus	15-30
1702070-1	1990	Chornic exogenous administration of cholecystokinin octapeptide (CCK8) to rats led to a reduced sensitivity of pancreatic acinar cells to both CCK8 and carbachol stimulation without changes in affinity or number of CCK or muscarinic receptors.	Carbachol	152-161	cholecystokinin	Rattus norvegicus	65-68
2175722-4	1990	Carbachol occupation of low affinity cholinergic receptors appears to produce a reduction in binding of 125I-CCK-8 and 125I-[Tyr4]bombesin.	Carbachol	0-9	gastrin releasing peptide	Homo sapiens	130-138
2175722-8	1990	Acini possess a single class of bombesin receptors and first incubating acini with carbachol caused a 40% decrease in the number of bombesin receptors with no change in their affinity for bombesin.	Carbachol	83-92	gastrin releasing peptide	Homo sapiens	32-40
2175722-8	1990	Acini possess a single class of bombesin receptors and first incubating acini with carbachol caused a 40% decrease in the number of bombesin receptors with no change in their affinity for bombesin.	Carbachol	83-92	gastrin releasing peptide	Homo sapiens	132-140
2175722-8	1990	Acini possess a single class of bombesin receptors and first incubating acini with carbachol caused a 40% decrease in the number of bombesin receptors with no change in their affinity for bombesin.	Carbachol	83-92	gastrin releasing peptide	Homo sapiens	132-140
2282996-1	1990	This study was designed to investigate the relationship between estrogen and progesterone receptor levels and in vitro contractile response of gallbladder muscle strips to stimulation by carbachol and cholecystokinin-octapeptide (CCK-OP).	Carbachol	187-196	progesterone receptor	Homo sapiens	77-98
2282996-5	1990	Positive correlations were found between the progesterone receptor level and the carbachol concentration that produced half the maximal response (ED50), and between the estrogen receptor level and the ED50 of CCK-OP.	Carbachol	81-90	progesterone receptor	Homo sapiens	45-66
1688390-1	1990	Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion.	Carbachol	149-164	protein kinase C, gamma	Rattus norvegicus	84-100
2153134-2	1990	In testing the possibility that VGCC may be functionally coupled to mAChR in SCC cell lines, we found that depolarization-dependent Ca2+ influx was inhibited by carbachol (IC50 = 0.78 microM) and oxotremorine (IC50 = 0.69 microM).	Carbachol	161-170	serpin family B member 3	Homo sapiens	77-80
2153134-4	1990	Exposure of SCC to carbachol induced the hydrolysis of phosphoinositides and increased the cytosolic free Ca2+ concentration ([Ca2+]i).	Carbachol	19-28	serpin family B member 3	Homo sapiens	12-15
33765249-4	2022	We found GlyT2 is down-regulated by carbachol in a calcium-dependent manner.	Carbachol	36-45	solute carrier family 6 member 5	Homo sapiens	9-14
2293258-9	1990	On the other hand, intracerebral injections of physostigmine (100 micrograms/microliter), an acetylcholinesterase inhibitor which elevates the level of endogenous acetylcholine, induced the fully developed emotional-aversive response comparable with natural behaviour and with responses induced by carbachol (10 micrograms/microliter).	Carbachol	298-307	acetylcholinesterase	Felis catus	93-113
33808507-3	2021	The current study showed that the release of a luciferase from a differentiated human neuroblastoma-based reporter cell line (SIMA-hPOMC1-26-GLuc cells) can be stimulated by a carbachol-mediated activation of the Gq-coupled muscarinic-acetylcholine receptor and by the Ca2+-channel forming spider toxin alpha-latrotoxin.	Carbachol	176-185	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	141-145
2130511-18	1990	Activation of phospholipase D (PLD) was demonstrated by the finding that phosphatidic acid increased in response to PMA or carbachol prior to the increase in PA.	Carbachol	123-132	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	14-29
2130511-18	1990	Activation of phospholipase D (PLD) was demonstrated by the finding that phosphatidic acid increased in response to PMA or carbachol prior to the increase in PA.	Carbachol	123-132	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
33765249-6	2022	GlyT2 down-regulation by carbachol was increased by thapsigargin and reduced by internal store depletion, although calcium release from endoplasmic reticulum or mitochondria had a minor role on GlyT2 inhibition.	Carbachol	25-34	solute carrier family 6 member 5	Homo sapiens	0-5
12384253-7	2002	In another set of experiments, the NK(1) receptor antagonist L-703-606 (5 microg) was microinjected near the A7 cell group following LH stimulation with carbachol.	Carbachol	153-162	tachykinin receptor 1	Rattus norvegicus	35-49
23744739-6	2013	Carbachol and cAMP redistributed CFTR to the apical membrane.	Carbachol	0-9	CF transmembrane conductance regulator	Homo sapiens	33-37
34878647-7	2022	Carbachol and a muscarinic M1 receptor (M1R) agonist facilitated KCNQ2 phosphorylation at T217 in NAc/striatum slices in a PKC-dependent manner.	Carbachol	0-9	potassium voltage-gated channel, subfamily Q, member 2	Mus musculus	65-70
7925360-6	1994	Short-term (30 min) incubation with carbachol (1 mM) induced a simultaneous transfer of a proportion of both Gq alpha and G11 alpha and Hm1 receptors from plasma membranes to distinct light vesicular membranes.	Carbachol	36-45	cholinergic receptor muscarinic 1	Homo sapiens	136-139
34418586-8	2022	Carbachol and PGE2 mediated mucin stimulation was examined by MUC2 IF/confocal microscopy and TEM.	Carbachol	0-9	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	62-66
34370080-10	2021	Application of the cholinomimetic drug carbachol or blocking M2R with methoctramine significantly promoted mucus secretion by goblet cells and increased MUC2 content in duodenal mucosa-incubated solutions from 6-OHDA and vagotomy rats.	Carbachol	39-48	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	153-157
34415562-10	2022	RESULTS: We found that carbachol increased the expression of NLRP3 inflammasome (NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18).	Carbachol	23-32	NLR family pyrin domain containing 3	Homo sapiens	61-66
34415562-10	2022	RESULTS: We found that carbachol increased the expression of NLRP3 inflammasome (NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18).	Carbachol	23-32	NLR family pyrin domain containing 3	Homo sapiens	81-86
34415562-10	2022	RESULTS: We found that carbachol increased the expression of NLRP3 inflammasome (NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18).	Carbachol	23-32	PYD and CARD domain containing	Homo sapiens	88-91
34415562-10	2022	RESULTS: We found that carbachol increased the expression of NLRP3 inflammasome (NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18).	Carbachol	23-32	caspase 1	Homo sapiens	101-110
34415562-10	2022	RESULTS: We found that carbachol increased the expression of NLRP3 inflammasome (NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18).	Carbachol	23-32	interleukin 1 alpha	Homo sapiens	112-120
34415562-10	2022	RESULTS: We found that carbachol increased the expression of NLRP3 inflammasome (NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18).	Carbachol	23-32	interleukin 18	Homo sapiens	126-131
34415562-13	2022	The addition of RA also significantly reduced the effect of carbachol on NLRP3 inflammasomes.	Carbachol	60-69	NLR family pyrin domain containing 3	Homo sapiens	73-78
34415562-14	2022	CONCLUSIONS: Our current study suggests that carbachol induces NLRP3 inflammasome activation through mAChR and NF-kB, and that RA abolishes the inflammatory response.	Carbachol	45-54	NLR family pyrin domain containing 3	Homo sapiens	63-68
34603302-11	2021	Similarly, disruption of IP3R/Ca2+ in MLE12 and RAW264.7 cells using carbachol lead to inflammatory responses, and stimulated ER stress and mitochondrial dysfunction.	Carbachol	69-78	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	25-29
34561235-3	2021	We show that cholinergic receptor activation with the non-selective cholinergic agonist, carbachol (CCh), triggers a protein synthesis-dependent and NMDAR-independent long-term synaptic depression (CCh-LTD) at entorhinal cortical (EC)-CA2 and Schaffer collateral (SC)-CA2 synapses in the hippocampus of adult male Wistar rats.	Carbachol	89-98	carbonic anhydrase 2	Rattus norvegicus	235-238
34561235-3	2021	We show that cholinergic receptor activation with the non-selective cholinergic agonist, carbachol (CCh), triggers a protein synthesis-dependent and NMDAR-independent long-term synaptic depression (CCh-LTD) at entorhinal cortical (EC)-CA2 and Schaffer collateral (SC)-CA2 synapses in the hippocampus of adult male Wistar rats.	Carbachol	89-98	carbonic anhydrase 2	Rattus norvegicus	268-271
34561235-3	2021	We show that cholinergic receptor activation with the non-selective cholinergic agonist, carbachol (CCh), triggers a protein synthesis-dependent and NMDAR-independent long-term synaptic depression (CCh-LTD) at entorhinal cortical (EC)-CA2 and Schaffer collateral (SC)-CA2 synapses in the hippocampus of adult male Wistar rats.	Carbachol	100-103	carbonic anhydrase 2	Rattus norvegicus	235-238
34561235-3	2021	We show that cholinergic receptor activation with the non-selective cholinergic agonist, carbachol (CCh), triggers a protein synthesis-dependent and NMDAR-independent long-term synaptic depression (CCh-LTD) at entorhinal cortical (EC)-CA2 and Schaffer collateral (SC)-CA2 synapses in the hippocampus of adult male Wistar rats.	Carbachol	100-103	carbonic anhydrase 2	Rattus norvegicus	268-271
34561235-4	2021	The activation of muscarinic acetylcholine receptors (mAChRs) is critical for the induction of CCh-LTD with the results suggesting an involvement of M3 and M1 mAChRs in the early facilitation of CCh-LTD, while nicotinic acetylcholine receptor activation plays a role in the late maintenance of CCh-LTD at CA2 synapses.	Carbachol	95-98	carbonic anhydrase 2	Rattus norvegicus	305-308
34561235-4	2021	The activation of muscarinic acetylcholine receptors (mAChRs) is critical for the induction of CCh-LTD with the results suggesting an involvement of M3 and M1 mAChRs in the early facilitation of CCh-LTD, while nicotinic acetylcholine receptor activation plays a role in the late maintenance of CCh-LTD at CA2 synapses.	Carbachol	294-297	carbonic anhydrase 2	Rattus norvegicus	305-308
34561235-5	2021	Remarkably, we find that CCh priming lowers the threshold for the subsequent induction of persistent long-term potentiation (LTP) of synaptic transmission at EC-CA2 and the plasticity-resistant SC-CA2 pathways.	Carbachol	25-28	carbonic anhydrase 2	Rattus norvegicus	161-164
34561235-5	2021	Remarkably, we find that CCh priming lowers the threshold for the subsequent induction of persistent long-term potentiation (LTP) of synaptic transmission at EC-CA2 and the plasticity-resistant SC-CA2 pathways.	Carbachol	25-28	carbonic anhydrase 2	Rattus norvegicus	197-200
34561235-8	2021	Moreover, the reinforcement of LTP at EC inputs to CA2 following the priming stimulus co-exists with concurrent sustained CCh-LTD at the SC-CA2 pathway and is dynamically scaled by modulation of SC-CA2 synaptic transmission.Significance Statement:The release of the neuromodulator acetylcholine is critically involved in processes of hippocampus-dependent memory formation.	Carbachol	122-125	carbonic anhydrase 2	Rattus norvegicus	140-143
34671658-6	2021	At 48 and 60 h, 10-5 M carbachol was used to stimulate gastrin secretion.	Carbachol	23-32	gastrin	Equus caballus	55-62
34671658-9	2021	Carbachol resulted in a significant increase in gastrin concentration in CO and DF treatments, but not in BL.	Carbachol	0-9	gastrin	Equus caballus	48-55
34487726-7	2021	CCh stimulation significantly elevates intracellular (Ca2+), an effect associated with increases in the size of Rab3D-enriched vesicles consistent with compound fusion, and subsequently decreases in their intensity of labeling consistent with their exocytosis.	Carbachol	0-3	RAB3D, member RAS oncogene family	Mus musculus	112-117
34487726-10	2021	Significant increases in the colocalization of endolysosomal vesicle markers (Lamp1, Lamp2, Rab7) with the subapical actin suggestive of fusion of endolysosomal vesicles at the apical membrane occur both with CCh and PE stimulation, but PE demonstrates increased colocalization.	Carbachol	209-212	lysosomal-associated membrane protein 1	Mus musculus	78-83
34487726-10	2021	Significant increases in the colocalization of endolysosomal vesicle markers (Lamp1, Lamp2, Rab7) with the subapical actin suggestive of fusion of endolysosomal vesicles at the apical membrane occur both with CCh and PE stimulation, but PE demonstrates increased colocalization.	Carbachol	209-212	lysosomal-associated membrane protein 2	Mus musculus	85-90
34487726-10	2021	Significant increases in the colocalization of endolysosomal vesicle markers (Lamp1, Lamp2, Rab7) with the subapical actin suggestive of fusion of endolysosomal vesicles at the apical membrane occur both with CCh and PE stimulation, but PE demonstrates increased colocalization.	Carbachol	209-212	RAB7, member RAS oncogene family	Mus musculus	92-96
34576086-7	2021	Accordingly, CRP4 KO mice presented with hypotonia at baseline, as well as a greater drop in systolic BP in response to the acute administration of cinaciguat, sodium nitroprusside, and carbachol.	Carbachol	186-195	cysteine rich protein 2	Mus musculus	13-17
34539433-7	2021	Accordingly, MRTF-B conferred responsiveness to the muscarinic agonist carbachol in Ca2+ imaging experiments.	Carbachol	71-80	myocardin related transcription factor B	Homo sapiens	13-19
34311523-9	2021	The major findings of the study reveal that- compared to the nondiabetic controls - the diabetic animals CC showed: (1) augmented contraction and attenuated relaxation in response to phenylephrine and carbachol, respectively, (2) marked fibromuscular degeneration with a significantly lower smooth muscle/collagen ratio and upregulation of TGF-beta-1/Smad/CTGF fibrosis signaling pathway, (3) reduced H2S plasma and urinary levels and cavernosal tissue generation.	Carbachol	201-210	transforming growth factor, beta 1	Rattus norvegicus	340-350
34512394-11	2021	CCh inhibited CaMKII activity, whereas CaMKII inhibition with KN93 mimicked the effect of CCh on Ca2+ transients in formamide-treated myocytes.	Carbachol	0-3	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	14-20
34177470-7	2021	In addition to theta power and frequency, intraseptal NBQX also attenuated suppression of CA1 population spike (PS) induced by intraseptal carbachol, thus suggesting that septal glutamate neurotransmission is involved in the spectrum of MS-mediated network responses.	Carbachol	139-148	carbonic anhydrase 1	Rattus norvegicus	90-93
34588752-6	2021	METHODS: In freshly dispersed smooth muscle cells (SMC), we measured the adiponectin effect on the carbachol-induced length changes.	Carbachol	99-108	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	73-84
34588752-7	2021	RESULTS: Adiponectin significantly reduced the carbachol-stimulated SMC shortening independently of age.	Carbachol	47-56	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	9-20
34180063-7	2021	Introduction of a non-phosphorylatable S675A mutant of beta-catenin into myoblasts impaired carbachol, a Rac1 and RhoA activator, stimulated GLUT4 translocation and actin remodelling in myoblasts, and exercise-induced increases in cross-sectional phalloidin staining (F-actin marker) of gastrocnemius muscle was impaired in muscle from BCAT-mKO.	Carbachol	92-101	catenin (cadherin associated protein), beta 1	Mus musculus	55-67
34180063-7	2021	Introduction of a non-phosphorylatable S675A mutant of beta-catenin into myoblasts impaired carbachol, a Rac1 and RhoA activator, stimulated GLUT4 translocation and actin remodelling in myoblasts, and exercise-induced increases in cross-sectional phalloidin staining (F-actin marker) of gastrocnemius muscle was impaired in muscle from BCAT-mKO.	Carbachol	92-101	Rac family small GTPase 1	Mus musculus	105-109
34180063-7	2021	Introduction of a non-phosphorylatable S675A mutant of beta-catenin into myoblasts impaired carbachol, a Rac1 and RhoA activator, stimulated GLUT4 translocation and actin remodelling in myoblasts, and exercise-induced increases in cross-sectional phalloidin staining (F-actin marker) of gastrocnemius muscle was impaired in muscle from BCAT-mKO.	Carbachol	92-101	ras homolog family member A	Mus musculus	114-118
34180063-7	2021	Introduction of a non-phosphorylatable S675A mutant of beta-catenin into myoblasts impaired carbachol, a Rac1 and RhoA activator, stimulated GLUT4 translocation and actin remodelling in myoblasts, and exercise-induced increases in cross-sectional phalloidin staining (F-actin marker) of gastrocnemius muscle was impaired in muscle from BCAT-mKO.	Carbachol	92-101	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	141-146
34385927-7	2021	Then, we investigated the role and mechanisms of MALAT1 in the proliferation, migration, phenotypic switch, and carbachol-induced intracellular Ca2+ changes in human gastric smooth muscle cells (HGSMCs) under high glucose (HG) conditions, using short hairpin RNA technology, RNA immunoprecipitation, and dual-luciferase reporter assays.	Carbachol	112-121	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	49-55
34385927-10	2021	Additionally, we show that MALAT1 sponged miR-449a, regulating Delta-like ligand 1 (DLL1) expression in HGSMCs; any disturbance of the MALAT1/miR-449a/DLL1 pathway affects the proliferation, migration, phenotypic switch, and carbachol-induced Ca2+ transient signals in HGSMCs under HG conditions.	Carbachol	225-234	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	27-33
34311523-9	2021	The major findings of the study reveal that- compared to the nondiabetic controls - the diabetic animals CC showed: (1) augmented contraction and attenuated relaxation in response to phenylephrine and carbachol, respectively, (2) marked fibromuscular degeneration with a significantly lower smooth muscle/collagen ratio and upregulation of TGF-beta-1/Smad/CTGF fibrosis signaling pathway, (3) reduced H2S plasma and urinary levels and cavernosal tissue generation.	Carbachol	201-210	cellular communication network factor 2	Rattus norvegicus	356-360
35427599-6	2022	qPCR and whole-mount immunohistochemical analysis in ex vivo organ culture system revealed that SG epithelial cells near a parasympathetic nerve were found to be induced to differentiate into MECs via the cholinergic receptor muscarinic 1 by carbachol (CCh), an acetylcholine agonist.	Carbachol	242-251	cholinergic receptor, muscarinic 1	Rattus norvegicus	205-238
35427599-6	2022	qPCR and whole-mount immunohistochemical analysis in ex vivo organ culture system revealed that SG epithelial cells near a parasympathetic nerve were found to be induced to differentiate into MECs via the cholinergic receptor muscarinic 1 by carbachol (CCh), an acetylcholine agonist.	Carbachol	253-256	cholinergic receptor, muscarinic 1	Rattus norvegicus	205-238
35427599-7	2022	In addition, CCh stimulated ERK and Akt signaling for the induction of MEC differentiation in rat submandibular gland epithelial cells.	Carbachol	13-16	Eph receptor B1	Rattus norvegicus	28-31
35427599-7	2022	In addition, CCh stimulated ERK and Akt signaling for the induction of MEC differentiation in rat submandibular gland epithelial cells.	Carbachol	13-16	AKT serine/threonine kinase 1	Rattus norvegicus	36-39
35431993-4	2022	The absence of extracellular Ca2+ influx after immersion into nominally zero Ca2+ solution, or the addition of nifedipine, significantly inhibited the contractile responses (p < 0.05 for all) after stimulation with carbachol (1 microM), histamine (100 microM), 5-hydroxytryptamine (100 microM), neurokinin-A (300 nM), prostaglandin E2 (10 microM), and angiotensin II (100 nM).	Carbachol	215-224	tachykinin precursor 1	Homo sapiens	295-307
35088452-9	2022	We found that exposure to propranolol either by combination with carbachol facilitates additive effects on inhibition of caspase 3 and 8 expression in chronic myeloid leukemia K562 cells.	Carbachol	65-74	caspase 3	Homo sapiens	121-136
35088452-10	2022	But caspase 9 expression level was increased by propranolol alone or with propranolol and Carbachol combination.	Carbachol	90-99	caspase 9	Homo sapiens	4-13
35431993-4	2022	The absence of extracellular Ca2+ influx after immersion into nominally zero Ca2+ solution, or the addition of nifedipine, significantly inhibited the contractile responses (p < 0.05 for all) after stimulation with carbachol (1 microM), histamine (100 microM), 5-hydroxytryptamine (100 microM), neurokinin-A (300 nM), prostaglandin E2 (10 microM), and angiotensin II (100 nM).	Carbachol	215-224	angiotensinogen	Homo sapiens	352-366
2531900-5	1989	Injection of carbachol into the AV3V produced the expected natriuresis, which was accompanied within 20 min by a dramatic rise in the plasma ANP concentration and a rise in ANP content in the medial basal hypothalamus, the neurohypophysis, and particularly the anterior hypophysis but without alterations in the content of ANP in the lungs or the right or left atrium.	Carbachol	13-22	natriuretic peptide A	Rattus norvegicus	141-144
35307777-7	2022	ALFA-tagged ArcNb also provided efficient immunoprecipitation of stimulus-induced Arc after carbachol-treatment of SH-SY5Y neuroblastoma cells and induction of long-term potentiation in the rat dentate gyrus in vivo.	Carbachol	92-101	activity regulated cytoskeleton associated protein	Homo sapiens	82-85
2557126-2	1989	Carbachol concentration-dependently induced the hydrolysis of inositol lipids and formation of [3H]IP3, [3H]IP2 and [3H]IP1 in these cells labeled with [3H]inositol.	Carbachol	0-9	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	108-111
2690956-4	1989	pHi remained unaffected after raising the glucose concentration from 3 to 20 mM, it was lowered when depolarizing the beta-cells with tolbutamide and it increased in the presence of carbachol.	Carbachol	182-191	glucose-6-phosphate isomerase 1	Mus musculus	0-3
2514601-0	1989	Carbachol-induced cytosolic free Ca2+ increases in T84 colonic cells seen by microfluorimetry.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	33-36
2514601-1	1989	Changes in cytosolic free Ca2+ ([Ca2+]i) in response to the secretagogue carbachol have been characterized in the human colon cancer cell line T84, a model Cl- secretory cell.	Carbachol	73-82	carbonic anhydrase 2	Homo sapiens	26-29
2514601-1	1989	Changes in cytosolic free Ca2+ ([Ca2+]i) in response to the secretagogue carbachol have been characterized in the human colon cancer cell line T84, a model Cl- secretory cell.	Carbachol	73-82	carbonic anhydrase 2	Homo sapiens	33-36
2514601-4	1989	The cholinergic agonist carbachol caused a concentration-dependent rise in [Ca2+]i with a Km of 4 microM and a peak increase in [Ca2+]i of approximately 50 nM.	Carbachol	24-33	carbonic anhydrase 2	Homo sapiens	76-79
2514601-4	1989	The cholinergic agonist carbachol caused a concentration-dependent rise in [Ca2+]i with a Km of 4 microM and a peak increase in [Ca2+]i of approximately 50 nM.	Carbachol	24-33	carbonic anhydrase 2	Homo sapiens	129-132
2514601-7	1989	In conclusion, the initial detectable increase in [Ca2+]i caused by carbachol is due to the release of Ca2+ from internal stores, whereas the contribution of extracellular Ca2+ occurs later and at least partially involves a nifedipine- and verapamil-sensitive process.	Carbachol	68-77	carbonic anhydrase 2	Homo sapiens	51-54
2514601-7	1989	In conclusion, the initial detectable increase in [Ca2+]i caused by carbachol is due to the release of Ca2+ from internal stores, whereas the contribution of extracellular Ca2+ occurs later and at least partially involves a nifedipine- and verapamil-sensitive process.	Carbachol	68-77	carbonic anhydrase 2	Homo sapiens	103-106
2514601-7	1989	In conclusion, the initial detectable increase in [Ca2+]i caused by carbachol is due to the release of Ca2+ from internal stores, whereas the contribution of extracellular Ca2+ occurs later and at least partially involves a nifedipine- and verapamil-sensitive process.	Carbachol	68-77	carbonic anhydrase 2	Homo sapiens	103-106
2531900-5	1989	Injection of carbachol into the AV3V produced the expected natriuresis, which was accompanied within 20 min by a dramatic rise in the plasma ANP concentration and a rise in ANP content in the medial basal hypothalamus, the neurohypophysis, and particularly the anterior hypophysis but without alterations in the content of ANP in the lungs or the right or left atrium.	Carbachol	13-22	natriuretic peptide A	Rattus norvegicus	173-176
2531900-5	1989	Injection of carbachol into the AV3V produced the expected natriuresis, which was accompanied within 20 min by a dramatic rise in the plasma ANP concentration and a rise in ANP content in the medial basal hypothalamus, the neurohypophysis, and particularly the anterior hypophysis but without alterations in the content of ANP in the lungs or the right or left atrium.	Carbachol	13-22	natriuretic peptide A	Rattus norvegicus	173-176
2531900-12	1989	The dramatic increase in plasma ANP after carbachol stimulation of the AV3V that was accompanied by marked elevations in content of the peptide in basal hypothalamus and neuro- and adenohypophysis suggests that the natriuresis resulting from this stimulation is brought about at least in part by release of ANP from the brain.	Carbachol	42-51	natriuretic peptide A	Rattus norvegicus	32-35
2531900-12	1989	The dramatic increase in plasma ANP after carbachol stimulation of the AV3V that was accompanied by marked elevations in content of the peptide in basal hypothalamus and neuro- and adenohypophysis suggests that the natriuresis resulting from this stimulation is brought about at least in part by release of ANP from the brain.	Carbachol	42-51	natriuretic peptide A	Rattus norvegicus	307-310
2591535-1	1989	In intact smooth muscle strips from chicken gizzard, electrical stimulation and carbachol elicited brief, phasic contractions which were associated with a very rapid, transient phosphorylation of the 20 kDa myosin light chains.	Carbachol	80-89	myosin, heavy chain 15	Gallus gallus	207-213
2556936-5	1989	The carbachol-induced changes in Isc appeared to be dependent on the increase in [Ca]i.	Carbachol	4-13	carbonic anhydrase 1	Homo sapiens	82-86
2556936-13	1989	These experiments suggest that although the carbachol-induced increase in Isc is dependent on the increase in [Ca]i, the hormone may activate a second process that increases the sensitivity of the calcium-activated transport process to changes in [Ca]i.	Carbachol	44-53	carbonic anhydrase 1	Homo sapiens	111-115
2556936-13	1989	These experiments suggest that although the carbachol-induced increase in Isc is dependent on the increase in [Ca]i, the hormone may activate a second process that increases the sensitivity of the calcium-activated transport process to changes in [Ca]i.	Carbachol	44-53	carbonic anhydrase 1	Homo sapiens	248-252
2514612-8	1989	Specific FITC-alpha-BGT binding to the nAChR protein on the optic fibers was inhibited by agonists (e.g., acetylcholine, nicotine, and carbamylcholine) and antagonists (e.g., pancuronium and d-tubocurarine) of the nAChR and was insensitive to high salt concentrations (e.g., 154 mM NaCl).	Carbachol	135-150	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	39-44
2531983-6	1989	Intravenous administration of VIP and carbachol significantly stimulated bicarbonate outputs, and these responses were blocked by the VIP antagonist and atropine, respectively.	Carbachol	38-47	vasoactive intestinal peptide	Rattus norvegicus	134-137
2531983-9	1989	The actions of peripheral VIP and carbachol appear to be mediated by specific VIP and muscarinic receptors, respectively.	Carbachol	34-43	vasoactive intestinal peptide	Rattus norvegicus	78-81
2482794-6	1989	The data indicate that the amount of Ca2+ mobilized by the muscarinic agonist carbachol or by cholecystokinin octapeptide increases with increasing thyroid hormone concentrations.	Carbachol	78-87	carbonic anhydrase 2	Rattus norvegicus	37-40
2596581-7	1989	Stimulation with carbachol resulted in progressive increases in the generation of inositol phosphates and rapid four- to fivefold increases in [Ca2+]i.	Carbachol	17-26	carbonic anhydrase 2	Anas platyrhynchos	144-147
2551763-2	1989	This study provides evidence suggesting that, in chronic gastric fistula rats, intracerebroventricularly administered NT (15-60 micrograms) significantly reduces both basal and pentagastrin-, 2-deoxy-D-glucose-, and carbachol-but not histamine-stimulated gastric acid secretion.	Carbachol	216-225	neurotensin	Rattus norvegicus	118-120
2554897-3	1989	ANF inhibited, in a dose-dependent manner, cholinergic twitch contractions (EC50 = 4.2 nM), nonadrenergic, noncholinergic (NANC) primary and rebound contractions and histamine-induced sustained tonic contraction (but not carbachol induced contraction) of the longitudinal muscle.	Carbachol	221-230	natriuretic peptide A	Rattus norvegicus	0-3
2482655-9	1989	When carbachol was given 20 s after the injection of VIP or CGRP, the secretory response was increased by about 250% and 60% respectively.	Carbachol	5-14	vasoactive intestinal peptide	Rattus norvegicus	53-56
2482655-0	1989	The enhancement of carbachol-induced salivary secretion by VIP and CGRP in rat parotid gland is mimicked by forskolin.	Carbachol	19-28	vasoactive intestinal peptide	Rattus norvegicus	59-62
2482655-0	1989	The enhancement of carbachol-induced salivary secretion by VIP and CGRP in rat parotid gland is mimicked by forskolin.	Carbachol	19-28	calcitonin-related polypeptide alpha	Rattus norvegicus	67-71
2482655-9	1989	When carbachol was given 20 s after the injection of VIP or CGRP, the secretory response was increased by about 250% and 60% respectively.	Carbachol	5-14	calcitonin-related polypeptide alpha	Rattus norvegicus	60-64
2795474-6	1989	Concentration-response curves for carbachol-stimulated [3H]inositol monophosphate [( 3H]IP1) accumulation were also obtained.	Carbachol	34-43	huntingtin interacting protein 1	Mus musculus	86-91
2804646-2	1989	injections (10 microliters) of carbachol (1.4 nmol), angiotensin II (AII; 48.2 pmol) or a hypertonic solution (990 mOsm/kg) produced increases of plasma vasopressin (AVP) and arterial pressure.	Carbachol	31-40	arginine vasopressin	Rattus norvegicus	153-164
2551183-1	1989	When dispersed acini from guinea pig pancreas are first incubated with carbachol, the subsequent binding of 125I-vasoactive intestinal peptide (VIP) is inhibited during a second incubation.	Carbachol	71-80	VIP peptides	Cavia porcellus	108-142
2551183-1	1989	When dispersed acini from guinea pig pancreas are first incubated with carbachol, the subsequent binding of 125I-vasoactive intestinal peptide (VIP) is inhibited during a second incubation.	Carbachol	71-80	VIP peptides	Cavia porcellus	144-147
2551183-2	1989	This inhibitory action of carbachol on binding of 125I-VIP depends on time, temperature, and the concentration of carbachol in the first incubation and can be blocked by atropine.	Carbachol	26-35	VIP peptides	Cavia porcellus	55-58
2551183-2	1989	This inhibitory action of carbachol on binding of 125I-VIP depends on time, temperature, and the concentration of carbachol in the first incubation and can be blocked by atropine.	Carbachol	114-123	VIP peptides	Cavia porcellus	55-58
2551183-4	1989	Adding EGTA to the first incubation medium abolishes the effect of carbachol on binding of 125I-VIP.	Carbachol	67-76	VIP peptides	Cavia porcellus	96-99
2551183-5	1989	In control acini or acini first incubated with carbachol, approximately half of the bound 125I-VIP can be stripped by acetic acid.	Carbachol	47-56	VIP peptides	Cavia porcellus	95-98
2551183-10	1989	The dose-response curve for carbachol-induced inhibition of binding of 125I-VIP and that for occupation of low-affinity muscarinic cholinergic receptors by carbachol are similar.	Carbachol	28-37	VIP peptides	Cavia porcellus	76-79
2550013-7	1989	Vasoactive intestinal polypeptide (VIP) caused a relaxation of smooth muscle cells maximally contracted by carbachol or CCK-8 or gastrin (EC50 = 2.2 nM) with a parallel increase in intracellular cAMP content.	Carbachol	107-116	VIP peptides	Oryctolagus cuniculus	0-33
2550013-7	1989	Vasoactive intestinal polypeptide (VIP) caused a relaxation of smooth muscle cells maximally contracted by carbachol or CCK-8 or gastrin (EC50 = 2.2 nM) with a parallel increase in intracellular cAMP content.	Carbachol	107-116	VIP peptides	Oryctolagus cuniculus	35-38
2572704-5	1989	Carbachol induced accumulation of mRNA for c-fos and the other TIS genes.	Carbachol	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	43-48
2554490-3	1989	Pretreatment of T84 cell layers with IFN-gamma for 24 h (but not for 3 h) markedly decreased the Cl- secretory response to vaso-active intestinal polypeptide (VIP) and to cholera toxin and carbachol without appreciably affecting the overall morphology, electrical resistance, or cyclic AMP response of the T84 cell monolayer.	Carbachol	189-198	interferon gamma	Homo sapiens	37-46
2548215-9	1989	The depolarizing agents choline (EC50 = 1 mM) and carbamoylcholine (EC50 = 1 microM), acting through nicotinic cholinergic receptors, also rescued NGF-deprived neurons.	Carbachol	50-66	nerve growth factor	Homo sapiens	147-150
2546748-7	1989	Moreover, naloxone (0.5 mg/kg) significantly increased AVP secretion induced by intracerebroventricular injection of carbachol (10 ng).	Carbachol	117-126	arginine vasopressin	Rattus norvegicus	55-58
2621591-3	1989	In all impaled CA3 pyramidal neurones, continuous applications of carbachol, a non-hydrolysable cholinergic agonist, induced first a brief non-rhythmic excitation and then periodic bursts of RSA which could persist for several hours.	Carbachol	66-75	carbonic anhydrase 3	Rattus norvegicus	15-18
2621591-8	1989	Analyses of simultaneous recordings from pairs of neurones, or a neurone and a glial cell, or a neurone and the extracellular field, indicated that carbachol-induced RSA was synchronous in a large population of CA3 pyramidal neurones.	Carbachol	148-157	carbonic anhydrase 3	Rattus norvegicus	211-214
2621591-15	1989	Raising extracellular [Ca2+] beyond 7 mM, which should significantly weaken the polysynaptic recurrent excitation among CA3 pyramidal neurones, abolished carbachol-induced RSA.	Carbachol	154-163	carbonic anhydrase 2	Rattus norvegicus	23-26
2621591-15	1989	Raising extracellular [Ca2+] beyond 7 mM, which should significantly weaken the polysynaptic recurrent excitation among CA3 pyramidal neurones, abolished carbachol-induced RSA.	Carbachol	154-163	carbonic anhydrase 3	Rattus norvegicus	120-123
2621591-16	1989	This suggests that the recurrent excitation among CA3 pyramidal neurones is necessary for carbachol-induced RSA in the CA3 area.	Carbachol	90-99	carbonic anhydrase 3	Rattus norvegicus	50-53
2621591-16	1989	This suggests that the recurrent excitation among CA3 pyramidal neurones is necessary for carbachol-induced RSA in the CA3 area.	Carbachol	90-99	carbonic anhydrase 3	Rattus norvegicus	119-122
2502025-4	1989	Carbachol increased phosphorylation of a 36-kDa, pI approximately 7 protein (pp36) and transient phosphorylation of a 28-kDa, pI approximately 5 protein (pp28), whereas histamine increased phosphorylation of 40-kDa, pI approximately 6.5 (pp40) and 27-kDa, pI approximately 6.2 (pp27) proteins.	Carbachol	0-9	linker for activation of T cells	Homo sapiens	77-81
2502025-7	1989	Chelation of [Ca2+]i and [Ca2+]o blocked carbachol-induced phosphorylation of pp28 and pp36 and ionomycin phosphorylation of pp28 but not TPA-stimulated phosphorylation of pp36 or the two pp66s or histamine-stimulated phosphorylation of pp27 or pp40.	Carbachol	41-50	linker for activation of T cells	Homo sapiens	87-91
2502025-7	1989	Chelation of [Ca2+]i and [Ca2+]o blocked carbachol-induced phosphorylation of pp28 and pp36 and ionomycin phosphorylation of pp28 but not TPA-stimulated phosphorylation of pp36 or the two pp66s or histamine-stimulated phosphorylation of pp27 or pp40.	Carbachol	41-50	linker for activation of T cells	Homo sapiens	172-176
2502025-10	1989	These phosphoproteins could be common elements of Ca2+-dependent stimulus-secretion coupling as similar proteins were phosphorylated by carbachol and cholecystokinin (CCK) in chief cells.	Carbachol	136-145	cholecystokinin	Homo sapiens	167-170
2478116-7	1989	Stimulation of monocyte C1-inh synthesis occurs after the addition of agents which induce the formation of sodium ion and calcium ion channels, activate the phosphatidyl inositol cycle and activate protein kinase C (immune-complexes, carbamylcholine and phenylephrine).	Carbachol	234-249	serpin family G member 1	Homo sapiens	24-30
2519894-8	1989	Quinacrine, the inhibitor of phospholipase A2, completely inhibits carbachol- and guanine nucleotide-activated AA release and greatly (by about 60-70%) decreases Ca(2+)-dependent AA liberation from phosphatidylinositol.	Carbachol	67-76	phospholipase A2 group IB	Homo sapiens	29-45
2519894-9	1989	These results indicate that GTP-binding protein(s) are involved in the regulation of carbachol-mediated AA release.	Carbachol	85-94	hydroxycarboxylic acid receptor 3	Homo sapiens	28-47
2723657-1	1989	We have examined the effects of the muscarinic agonist carbachol on the intracellular free Ca2+ concentration ([Ca2+]i) in primary cultures of neurons from rat forebrain using the Ca2+-sensitive fluorescent dye fura-2.	Carbachol	55-64	carbonic anhydrase 2	Rattus norvegicus	91-94
2723657-1	1989	We have examined the effects of the muscarinic agonist carbachol on the intracellular free Ca2+ concentration ([Ca2+]i) in primary cultures of neurons from rat forebrain using the Ca2+-sensitive fluorescent dye fura-2.	Carbachol	55-64	carbonic anhydrase 2	Rattus norvegicus	112-115
2723657-1	1989	We have examined the effects of the muscarinic agonist carbachol on the intracellular free Ca2+ concentration ([Ca2+]i) in primary cultures of neurons from rat forebrain using the Ca2+-sensitive fluorescent dye fura-2.	Carbachol	55-64	carbonic anhydrase 2	Rattus norvegicus	112-115
2723657-2	1989	Addition of carbachol increased the [Ca2+]i in approximately 60% of cells studied.	Carbachol	12-21	carbonic anhydrase 2	Rattus norvegicus	37-40
2758328-1	1989	Long-term potentiation (LTP) in the CA3 hippocampal subfield, elicited in vivo, produced significant increases in basal and in carbachol- and noradrenaline-induced hydrolysis of phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2) as measured by the accumulation of InsP1 in hippocampal slices in vitro.	Carbachol	127-136	carbonic anhydrase 3	Homo sapiens	36-39
2527757-2	1989	ANP at concentrations greater than 10(-9) M inhibited carbachol-induced EDRF release from rabbit aorta and acetylcholine-induced EDRF release from the central ear artery.	Carbachol	54-63	natriuretic peptides A	Oryctolagus cuniculus	0-3
2498332-2	1989	Signal transduction by thyrotropin-releasing hormone (TRH) and carbamylcholine (CCH) in some cells is mediated by inositol lipid hydrolysis forming the second messengers, inositol 1,4,5-trisphosphate (I-1,4,5-P3) and 1,2-diacylglycerol, and causing elevation of cytoplasmic free Ca2+ concentration [( Ca2+]i).	Carbachol	80-83	thyrotropin releasing hormone	Mus musculus	23-52
2498332-4	1989	TRH, at maximally effective doses, stimulated a rapid marked increase in I-1,4,5-P3 which was associated with a rapid elevation of [Ca2+]i to approximately 1000 nM, whereas maximally effective doses of CCH caused little increase in I-1,4,5-P3 and no burst elevation of [Ca2+]i.	Carbachol	202-205	thyrotropin releasing hormone	Mus musculus	0-3
2498332-6	1989	CCH-like responses were observed when TtT cells were stimulated by low doses of TRH.	Carbachol	0-3	thyrotropin releasing hormone	Mus musculus	80-83
2498332-8	1989	Lastly, CCH-like responses were observed with maximally effective doses of TRH when the TRH receptor number was down-regulated to a level similar to that of muscarinic receptors.	Carbachol	8-11	thyrotropin releasing hormone	Mus musculus	75-78
2498332-8	1989	Lastly, CCH-like responses were observed with maximally effective doses of TRH when the TRH receptor number was down-regulated to a level similar to that of muscarinic receptors.	Carbachol	8-11	thyrotropin releasing hormone	Mus musculus	88-91
2667680-11	1989	Adenosine selectively reduced the sensitivity of CA1 neurones to microiontophoretically applied carbachol whereas stable nucleotides did not.	Carbachol	96-105	carbonic anhydrase 1	Rattus norvegicus	49-52
2758227-7	1989	Carbachol induced a marked Ca2+-dependent increase in the release of acetylcholinesterase but had no effect on the release of butyrylcholinesterase or lactate dehydrogenase.	Carbachol	0-9	acetylcholinesterase	Cavia porcellus	69-89
2758227-8	1989	This carbachol-evoked increase in acetylcholinesterase release was blocked by hexamethonium but not by atropine.	Carbachol	5-14	acetylcholinesterase	Cavia porcellus	34-54
2475163-12	1989	The spectroscopic properties of the fluorescent probe ethidium have been used to investigate the effect of the mAbs on the interaction of the agonist carbamylcholine with nAChR in membranes.	Carbachol	150-165	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	171-176
2707169-0	1989	The glucocorticoid hormone dexamethasone reverses the growth hormone-releasing properties of the cholinomimetic carbachol.	Carbachol	112-121	gonadotropin releasing hormone receptor	Rattus norvegicus	54-68
2753222-0	1989	Stimulation and inhibition of prolactin release from rat pituitary lactotrophs by the cholinomimetic carbachol in vitro.	Carbachol	101-110	prolactin	Rattus norvegicus	30-39
2753222-2	1989	The prolactin (PRL) response of perifused rat pituitary tissue to the cholinomimetic agent carbachol (CARB) was studied under various in vitro conditions.	Carbachol	91-100	prolactin	Rattus norvegicus	4-13
2753222-2	1989	The prolactin (PRL) response of perifused rat pituitary tissue to the cholinomimetic agent carbachol (CARB) was studied under various in vitro conditions.	Carbachol	91-100	prolactin	Rattus norvegicus	15-18
2753222-2	1989	The prolactin (PRL) response of perifused rat pituitary tissue to the cholinomimetic agent carbachol (CARB) was studied under various in vitro conditions.	Carbachol	102-106	prolactin	Rattus norvegicus	4-13
2753222-4	1989	When established in organ culture for 3 days in a serum-free chemically defined medium, there was a significant increase of PRL release in response to CARB.	Carbachol	151-155	prolactin	Rattus norvegicus	124-127
2753222-5	1989	This PRL releasing activity of CARB depended on the hormonal environment of the culture medium: supplementation of the culture medium with triiodothyronine (T3) and the glucocorticoid dexamethasone (DEX) completely reversed the PRL releasing activity of CARB into an inhibition of PRL release.	Carbachol	31-35	prolactin	Rattus norvegicus	5-8
2753222-5	1989	This PRL releasing activity of CARB depended on the hormonal environment of the culture medium: supplementation of the culture medium with triiodothyronine (T3) and the glucocorticoid dexamethasone (DEX) completely reversed the PRL releasing activity of CARB into an inhibition of PRL release.	Carbachol	31-35	prolactin	Rattus norvegicus	228-231
2753222-5	1989	This PRL releasing activity of CARB depended on the hormonal environment of the culture medium: supplementation of the culture medium with triiodothyronine (T3) and the glucocorticoid dexamethasone (DEX) completely reversed the PRL releasing activity of CARB into an inhibition of PRL release.	Carbachol	31-35	prolactin	Rattus norvegicus	228-231
2539375-3	1989	Stimulation of these cells with serotonin, histamine, carbachol, or the Ca2+ ionophore, ionomycin, increases free cytosolic Ca2+ concentrations and the extent of myosin light chain phosphorylation.	Carbachol	54-63	myosin heavy chain 14	Homo sapiens	162-168
2541684-6	1989	PtdIns3P is metabolically closely related to the pool(s) of inositol phospholipid(s) that serves as substrate(s) for an agonist-sensitive phosphoinositidase C, as the levels of PtdIns3P fell significantly when 1321 N1 cells were stimulated with carbachol.	Carbachol	245-254	phospholipase C beta 1	Homo sapiens	138-158
2748539-1	1989	The antinociceptive effect of intrathecally administered carbachol at the L1/L2 level in the rat was evaluated using the tail immersion test.	Carbachol	57-66	ribosomal protein L4	Rattus norvegicus	74-79
2737706-4	1989	Intravenous vasopressin antagonist, d(CH2)5Tyr(Me) arginine vasopressin, significantly attenuated the pressor response and eliminated the bradycardic response to carbachol in Long-Evans rats.	Carbachol	162-171	arginine vasopressin	Rattus norvegicus	12-23
2577684-3	1989	Both glucose and theophylline stimulation gave significant increases in somatostatin secretion, whereas carbachol inhibits the somatostatin secretion at 25 mmol l-1 glucose but not at 5 mmol l-1 glucose.	Carbachol	104-113	somatostatin	Rattus norvegicus	127-139
2466407-2	1989	Atrial natriuretic factor (ANF), atriopeptin II, and atriopeptin III were found to induce relaxation of tracheal smooth muscle precontracted with 5 x 10(-8) M carbachol (an approximate median effective concentration) in a concentration-dependent manner.	Carbachol	159-168	natriuretic peptide A	Bos taurus	0-25
2466407-2	1989	Atrial natriuretic factor (ANF), atriopeptin II, and atriopeptin III were found to induce relaxation of tracheal smooth muscle precontracted with 5 x 10(-8) M carbachol (an approximate median effective concentration) in a concentration-dependent manner.	Carbachol	159-168	natriuretic peptide A	Bos taurus	27-30
2466407-5	1989	However, the relaxant effects of ANF, atriopeptin II, and atriopeptin III were much less when a higher concentration of carbachol or 30 mM K+ was used as the contractile agent.	Carbachol	120-129	natriuretic peptide A	Bos taurus	33-36
2466407-6	1989	Maximally inhibitory concentration (IC50) values of ANF, atriopeptin II, and atriopeptin III for inhibition of muscle contraction induced by 5 x 10(-8) M carbachol ranged from 3.8 to 8.3 x 10(-9) M, indicating that these peptides have intermediate potency between isoproterenol (IC50, 2.0 x 10(-9) M) and sodium nitroprusside (IC50, 2.0 x 10(-8) M).	Carbachol	154-163	natriuretic peptide A	Bos taurus	52-55
2466407-7	1989	Treatment of the muscle with 3 x 10(-7) M ANF slowed the rate of tension development of the muscle by 10(-7) M carbachol.	Carbachol	111-120	natriuretic peptide A	Bos taurus	42-45
2466411-3	1989	Hybridization to dot blots of total parietal cell RNA showed a significant increase in specific CA II mRNA content within minutes of secretagogue addition: carbachol stimulation led to an increase of 52 +/- 8.9%, reaching a maximum within 20 min; gastrin stimulation led to an increase within 60 min of 104 +/- 10.6%; stimulation with histamine was followed within 20 min by an increase of 30 +/- 7.2%.	Carbachol	156-165	gastrin	Canis lupus familiaris	247-254
2737706-4	1989	Intravenous vasopressin antagonist, d(CH2)5Tyr(Me) arginine vasopressin, significantly attenuated the pressor response and eliminated the bradycardic response to carbachol in Long-Evans rats.	Carbachol	162-171	arginine vasopressin	Rattus norvegicus	60-71
2737706-7	1989	Combined intravenous treatment with phentolamine and vasopressin antagonist completely eliminated the pressor response to carbachol in Long-Evans rats.	Carbachol	122-131	arginine vasopressin	Rattus norvegicus	53-64
2737706-10	1989	Hypertensive response to intracerebroventricularly administered carbachol in normal rats is mediated both by an increase in central sympathetic outflow and in circulating vasopressin.	Carbachol	64-73	arginine vasopressin	Rattus norvegicus	171-182
2566191-3	1989	Somatostatin inhibited ion secretion evoked by EFS (55-65%), carbachol (80%) and VIP (95%) in a dose-dependent manner.	Carbachol	61-70	somatostatin	Rattus norvegicus	0-12
2566191-6	1989	In contrast, vasopressin in concentrations as low as 0.025-0.25 U/liter decreased the secretory effects of EFS (55-75%) and carbachol (85%), but had no effect on cAMP-dependent secretion elicited either by VIP or forskolin.	Carbachol	124-133	arginine vasopressin	Rattus norvegicus	13-24
2538074-5	1989	In conditions where carbachol stimulated mucin secretion from filter-grown Cl.16E cells, VIP, dibutyryl adenosine 3",5"-cyclic monophosphate (DbcAMP), or forskolin did not alter basal secretion.	Carbachol	20-29	LOC100508689	Homo sapiens	41-46
2538074-6	1989	However, VIP strongly potentiated carbachol-induced mucin secretion, since carbachol alone and VIP plus carbachol induced a 1.6- and 3.6-fold increase of mucin secretion above basal, respectively.	Carbachol	34-43	vasoactive intestinal peptide	Homo sapiens	9-12
2538074-6	1989	However, VIP strongly potentiated carbachol-induced mucin secretion, since carbachol alone and VIP plus carbachol induced a 1.6- and 3.6-fold increase of mucin secretion above basal, respectively.	Carbachol	34-43	LOC100508689	Homo sapiens	52-57
2538074-6	1989	However, VIP strongly potentiated carbachol-induced mucin secretion, since carbachol alone and VIP plus carbachol induced a 1.6- and 3.6-fold increase of mucin secretion above basal, respectively.	Carbachol	34-43	vasoactive intestinal peptide	Homo sapiens	95-98
2538074-6	1989	However, VIP strongly potentiated carbachol-induced mucin secretion, since carbachol alone and VIP plus carbachol induced a 1.6- and 3.6-fold increase of mucin secretion above basal, respectively.	Carbachol	34-43	LOC100508689	Homo sapiens	154-159
2538074-6	1989	However, VIP strongly potentiated carbachol-induced mucin secretion, since carbachol alone and VIP plus carbachol induced a 1.6- and 3.6-fold increase of mucin secretion above basal, respectively.	Carbachol	75-84	LOC100508689	Homo sapiens	154-159
2538074-6	1989	However, VIP strongly potentiated carbachol-induced mucin secretion, since carbachol alone and VIP plus carbachol induced a 1.6- and 3.6-fold increase of mucin secretion above basal, respectively.	Carbachol	75-84	LOC100508689	Homo sapiens	154-159
2783692-8	1989	The Ca2+ ionophore ionomycin, and two other Ca2+-mobilizing hormones, bradykinin and histamine, mimic the effects of carbachol.	Carbachol	117-126	kininogen 1	Homo sapiens	70-80
2755876-4	1989	The neuropeptide function of neuromedin C and/or other BLI peptides at this level was supported by the stimulatory effect of carbamylcholine (500 microM) on the release of BLI (4.5-fold increase over the basal release of 19 fmol/5 min) from perfused bovine adrenal glands.	Carbachol	125-140	gastrin releasing peptide	Homo sapiens	29-41
2919678-1	1989	In previous studies we demonstrated that parietal cell stimulation with gastrin and carbamoylcholine (carbachol) is accompanied by increased turnover of membrane inositol phospholipids.	Carbachol	102-111	gastrin	Homo sapiens	72-79
2531022-0	1989	[TRH dissociates the aggressivity of vegetative and motor phenomena induced by carbachol in the cat].	Carbachol	79-88	thyrotropin releasing hormone	Felis catus	1-4
2805565-5	1989	The naphthalene sulfonamides W7 and W5 which bind calmodulin and thus block the intracellular transduction of Ca2+ effects also inhibited a carbachol-induced H+ production.	Carbachol	140-149	calmodulin 1	Rattus norvegicus	50-60
2561651-4	1989	Carbachol-induced a stimulation of the PPI turnover cycle: namely, a decrease in 32Pi incorporation into phosphatidylinositol-4,5-bisphosphate (TPI) and phosphatidylinositol-4-phosphate (DPI), and an increase in this incorporation into phosphatidylinositol (PI) and phosphatidic acid (PA) in rat brain synaptosomes from the cerebrum.	Carbachol	0-9	triosephosphate isomerase 1	Rattus norvegicus	144-147
2558909-5	1989	Preliminary experiments on CA1 neurons in hippocampal slices (by single electrode voltage clamp), confirmed previous reports that carbachol depresses A- and C-type K currents, as well as inward Ca2+ currents; though the latter effect was sometimes mainly due to frequency-dependent inactivation of Ca currents.	Carbachol	130-139	carbonic anhydrase 1	Rattus norvegicus	27-30
2474153-1	1989	CCK-8-induced desensitization of carbachol-stimulated amylase secretion occurred over a range of concentrations of CCK-8 that occupy low affinity CCK receptors.	Carbachol	33-42	cholecystokinin	Homo sapiens	0-3
2474153-1	1989	CCK-8-induced desensitization of carbachol-stimulated amylase secretion occurred over a range of concentrations of CCK-8 that occupy low affinity CCK receptors.	Carbachol	33-42	cholecystokinin	Homo sapiens	115-118
2474153-1	1989	CCK-8-induced desensitization of carbachol-stimulated amylase secretion occurred over a range of concentrations of CCK-8 that occupy low affinity CCK receptors.	Carbachol	33-42	cholecystokinin	Homo sapiens	115-118
2474153-3	1989	Analysis of the relationship between receptor occupation and CCK-8-induced desensitization caused by CCK-8 and CCK-JMV-180 in combination also indicated that CCK-8-induced desensitization of carbachol-stimulated amylase secretion is caused by occupation of low affinity CCK receptors.	Carbachol	191-200	cholecystokinin	Homo sapiens	61-64
2474153-3	1989	Analysis of the relationship between receptor occupation and CCK-8-induced desensitization caused by CCK-8 and CCK-JMV-180 in combination also indicated that CCK-8-induced desensitization of carbachol-stimulated amylase secretion is caused by occupation of low affinity CCK receptors.	Carbachol	191-200	cholecystokinin	Homo sapiens	101-104
2474153-3	1989	Analysis of the relationship between receptor occupation and CCK-8-induced desensitization caused by CCK-8 and CCK-JMV-180 in combination also indicated that CCK-8-induced desensitization of carbachol-stimulated amylase secretion is caused by occupation of low affinity CCK receptors.	Carbachol	191-200	cholecystokinin	Homo sapiens	101-104
2474153-3	1989	Analysis of the relationship between receptor occupation and CCK-8-induced desensitization caused by CCK-8 and CCK-JMV-180 in combination also indicated that CCK-8-induced desensitization of carbachol-stimulated amylase secretion is caused by occupation of low affinity CCK receptors.	Carbachol	191-200	cholecystokinin	Homo sapiens	101-104
2474153-3	1989	Analysis of the relationship between receptor occupation and CCK-8-induced desensitization caused by CCK-8 and CCK-JMV-180 in combination also indicated that CCK-8-induced desensitization of carbachol-stimulated amylase secretion is caused by occupation of low affinity CCK receptors.	Carbachol	191-200	cholecystokinin	Homo sapiens	101-104
2575762-2	1989	Carvedilol produced competitive antagonism of the beta 1-adrenoceptor mediated positive chronotropic response to isoproterenol in guinea pig atria, and the beta 2-adrenoceptor mediated relaxation to isoproterenol in carbachol (1 mumol/l) precontracted guinea pig trachea, with a dissociation constant (KB) for beta 1-adrenoceptors of 0.8 nmol/l and beta 2-adrenoceptors of 1.3 nmol/l.	Carbachol	216-225	beta-2 adrenergic receptor	Cavia porcellus	156-175
2464057-1	1989	The new calmodulin antagonist, CGS-9343B, was found to inhibit both histamine plus 3-isobutyl-1-methylxanthine and carbachol-induced [14C]aminopyrine accumulation in dispersed, fundic mucosal cells of rats.	Carbachol	115-124	calmodulin 1	Rattus norvegicus	8-18
2660131-7	1989	In contrast, insulin secretion stimulated by glucose or the cholinergic agonist carbachol was inhibited by PYY (by 33 and 26%, respectively, at 4.25 nmol/kg).	Carbachol	80-89	peptide YY	Mus musculus	107-110
2660131-8	1989	Similarly, carbachol-induced glucagon secretion was inhibited by PYY (by 47% at 4.25 nmol/kg).	Carbachol	11-20	peptide YY	Mus musculus	65-68
2666982-8	1989	Secretion of PP by SL and UP cultures in response to 5 microM carbachol and 2.8 mM glucose in a 2-h incubation was significantly greater, 2.2- (p less than 0.002) and 3.9-fold (p less than 0.002), respectively, than secretion by respective control cultures without carbachol.	Carbachol	62-71	pancreatic polypeptide	Canis lupus familiaris	13-15
2666982-8	1989	Secretion of PP by SL and UP cultures in response to 5 microM carbachol and 2.8 mM glucose in a 2-h incubation was significantly greater, 2.2- (p less than 0.002) and 3.9-fold (p less than 0.002), respectively, than secretion by respective control cultures without carbachol.	Carbachol	265-274	pancreatic polypeptide	Canis lupus familiaris	13-15
2848833-3	1988	Muscarinic stimulation (carbachol) of the acini produced a gradual rise in pHi (approximately 0.1 unit by 10 min) possibly due to activation of the Na+/H+ exchanger.	Carbachol	24-33	glucose-6-phosphate isomerase	Rattus norvegicus	75-78
2848833-4	1988	When the exchanger was blocked by amiloride or sodium removal, carbachol induced a dramatic (atropine inhibitable) decrease in pHi (approximately 0.4 pH unit with t1/2 approximately 0.5 min at 1 mM carbachol).	Carbachol	63-72	glucose-6-phosphate isomerase	Rattus norvegicus	127-130
2848833-4	1988	When the exchanger was blocked by amiloride or sodium removal, carbachol induced a dramatic (atropine inhibitable) decrease in pHi (approximately 0.4 pH unit with t1/2 approximately 0.5 min at 1 mM carbachol).	Carbachol	198-207	glucose-6-phosphate isomerase	Rattus norvegicus	127-130
3075611-7	1988	Carbachol raised plasma gastrin immunoreactivity; but in no instance was there a significant relationship between gastric secretion and plasma gastrin immunoreactivity.	Carbachol	0-9	gastrin	Canis lupus familiaris	24-31
3075611-10	1988	PP plasma immunoreactivity was elevated by methacholine and carbachol.	Carbachol	60-69	pancreatic polypeptide	Canis lupus familiaris	0-2
2783255-2	1989	Both NGF and EGF potentiate in these cells the increase in the accumulation of inositol phosphates that is elicited by bradykinin and carbachol.	Carbachol	134-143	nerve growth factor	Rattus norvegicus	5-8
2783255-2	1989	Both NGF and EGF potentiate in these cells the increase in the accumulation of inositol phosphates that is elicited by bradykinin and carbachol.	Carbachol	134-143	epidermal growth factor like 1	Rattus norvegicus	13-16
2847543-3	1988	Cultured cells also showed the ability to secrete immunoreactive gastrin, and this secretion was further concentration-dependently stimulated by secretin (10(-10)-10(-6) M), carbachol (10(-6) M), and bombesin (10(-10)-10(-6) M).	Carbachol	174-183	gastrin	Homo sapiens	65-72
2847543-3	1988	Cultured cells also showed the ability to secrete immunoreactive gastrin, and this secretion was further concentration-dependently stimulated by secretin (10(-10)-10(-6) M), carbachol (10(-6) M), and bombesin (10(-10)-10(-6) M).	Carbachol	174-183	gastrin releasing peptide	Homo sapiens	200-208
3237319-2	1988	An intraventricular injection of hypertonic saline, carbachol, angiotensin II, prostaglandin E2 or histamine to a rabbit increased the concentrations of plasma AVP and OXT, whereas serotonin decreased their plasma levels.	Carbachol	52-61	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	160-163
2846548-13	1988	These results show (a) that the beta 2-adrenoceptor couples in isolated tracheal smooth muscle cells to a dihydropyridine- and pertussis toxin-sensitive calcium channel; (b) that the same channel is opened by carbachol; (c) that cGMP kinase is very effective in decreasing elevated cytosolic calcium concentrations, whereas cAMP-dependent protein kinase has a variable effect on stimulated cytosolic calcium levels.	Carbachol	209-218	adrenoceptor beta 2	Bos taurus	32-51
2464161-5	1988	While all these agents cause chloride secretion by elevating intracellular cAMP, NPY is also effective in inhibiting the secretory effects of carbachol (CCh) and substance P (SP), agents believed to act by raising intracellular calcium (Cai).	Carbachol	142-151	neuropeptide Y	Rattus norvegicus	81-84
2464161-5	1988	While all these agents cause chloride secretion by elevating intracellular cAMP, NPY is also effective in inhibiting the secretory effects of carbachol (CCh) and substance P (SP), agents believed to act by raising intracellular calcium (Cai).	Carbachol	153-156	neuropeptide Y	Rattus norvegicus	81-84
3170551-6	1988	Carbachol (10 microM) or ionomycin (10 microM) stimulation of fura-2-containing cells resulted in a rapid increase in cytosolic free Ca2+ concentration and in the extent of myosin light chain phosphorylation.	Carbachol	0-9	myosin heavy chain 14	Homo sapiens	173-179
3170551-10	1988	There was a similar relationship between free cytosolic Ca2+ concentrations and the extent of myosin light chain phosphorylation in carbachol- and ionomycin-stimulated cells.	Carbachol	132-141	myosin heavy chain 14	Homo sapiens	94-100
3237319-2	1988	An intraventricular injection of hypertonic saline, carbachol, angiotensin II, prostaglandin E2 or histamine to a rabbit increased the concentrations of plasma AVP and OXT, whereas serotonin decreased their plasma levels.	Carbachol	52-61	oxytocin	Oryctolagus cuniculus	168-171
3148968-3	1988	Infusion of gastrin-releasing peptide at 10(-8) M significantly increased pepsin output (from 87 +/- 17 to 129 +/- 22 units pepsin/min) and simultaneous infusion of gastrin-releasing peptide and carbachol at 10(-8) and 10(-6) M, respectively, resulted in an increase to almost 4 times the basal values.	Carbachol	195-204	gastrin releasing peptide	Rattus norvegicus	12-37
2843365-14	1988	Inhibition was partly improved (60% inhibition at 1 microM carbachol) when the contribution of the Gs-C species was decreased by lowering the concentration of local PGI2.	Carbachol	59-68	goosecoid homeobox	Homo sapiens	99-103
3417778-6	1988	Exposure of chick myotubes to the cholinergic agonist carbamylcholine was found to cause a dispersal of AChR clusters with a time course similar to that of TPA.	Carbachol	54-69	cholinergic receptor nicotinic delta subunit	Gallus gallus	104-108
3417778-7	1988	Like TPA, carbamylcholine enhances the phosphorylation of the delta-subunit of AChR.	Carbachol	10-25	cholinergic receptor nicotinic delta subunit	Gallus gallus	79-83
3417778-8	1988	The carbamylcholine-induced redistribution and phosphorylation of AChR is blocked by the nicotinic AChR antagonist d-tubocurarine.	Carbachol	4-19	cholinergic receptor nicotinic delta subunit	Gallus gallus	66-70
3417778-8	1988	The carbamylcholine-induced redistribution and phosphorylation of AChR is blocked by the nicotinic AChR antagonist d-tubocurarine.	Carbachol	4-19	cholinergic receptor nicotinic delta subunit	Gallus gallus	99-103
2903467-3	1988	Barium and carbachol both inactivate the m-current and these results suggest that somatostatin may exert its hyperpolarizing action on CA1 pyramidal cells by activation of the m-current.	Carbachol	11-20	carbonic anhydrase 1	Homo sapiens	135-138
3404446-1	1988	We investigated whether the inhibition of prolactin secretion from pituitary cells by carbachol, a cholinergic agonist resistant to hydrolysis by cholinesterases, would be a useful bioassay to explore an important nonneuronal action of antimuscarinic agents.	Carbachol	86-95	prolactin	Rattus norvegicus	42-51
3404446-2	1988	Carbachol inhibited prolactin secretion from cultured rat anterior pituitary cells in a dose-dependent manner with a mean IC50 of 1.5 +/- 0.6 (S.E.)	Carbachol	0-9	prolactin	Rattus norvegicus	20-29
2457366-4	1988	The half-maximal concentration for carbachol-stimulation of cAMP levels (6 microM) was similar to that for the previously determined carbachol-induced stimulation of phosphoinositide turnover in these cells, suggesting that the former is mediated by the latter.	Carbachol	35-44	cathelicidin antimicrobial peptide	Homo sapiens	60-64
3208090-1	1988	Iontophoretic application of carbachol caused excitation of CA1 neurones and decreased the amplitude of antidromic CA1 population spikes recorded extracellularly.	Carbachol	29-38	carbonic anhydrase 1	Rattus norvegicus	60-63
3208090-1	1988	Iontophoretic application of carbachol caused excitation of CA1 neurones and decreased the amplitude of antidromic CA1 population spikes recorded extracellularly.	Carbachol	29-38	carbonic anhydrase 1	Rattus norvegicus	115-118
3139031-3	1988	Pretreatment of cultures from both ages by Bordetella pertussis toxin (IAP) was found to eliminate any Gpp(NH)p effect on carbamylcholine binding.	Carbachol	122-137	Cd47 molecule	Rattus norvegicus	71-74
3139031-4	1988	IAP by itself induced a rightward shift in the carbamylcholine competition curve in homogenates from aged cultures, but no such effect was observed in homogenates from young cultures.	Carbachol	47-62	Cd47 molecule	Rattus norvegicus	0-3
3140614-3	1988	The ACE inhibitors antagonised adrenaline-, carbachol- and A23187-stimulated PGI2 synthesis in the aorta and bladder (CGS14824A greater than captopril greater than CGS14831) but were without effect on trauma- or arachidonate-stimulated PGI2 synthesis.	Carbachol	44-53	angiotensin I converting enzyme	Rattus norvegicus	4-7
2841015-5	1988	Pretreatment of cells with IAP prior to carbachol exposure partially blocked the subsequent decrease in receptor number.	Carbachol	40-49	magnesium transporter 1	Mus musculus	27-30
2454032-1	1988	Rat calcitonin gene-related peptide (rat CGRP) and related peptides did not cause contraction of gastric smooth muscle cells; however, preincubation with rat CGRP or human CGRP inhibited smooth muscle contraction caused by carbachol.	Carbachol	223-232	calcitonin-related polypeptide alpha	Rattus norvegicus	158-162
2454032-1	1988	Rat calcitonin gene-related peptide (rat CGRP) and related peptides did not cause contraction of gastric smooth muscle cells; however, preincubation with rat CGRP or human CGRP inhibited smooth muscle contraction caused by carbachol.	Carbachol	223-232	calcitonin related polypeptide alpha	Homo sapiens	158-162
3395782-0	1988	Positive inotropic effects induced by carbachol in rat atria treated with islet-activating protein (IAP)--association with phosphatidylinositol breakdown.	Carbachol	38-47	Cd47 molecule	Rattus norvegicus	100-103
3390705-1	1988	Effects of pertussis toxin or cholera toxin on carbachol-stimulated inositol-1-phosphate ([3H]IP1) accumulation were studied using the human neuroblastoma cell line (SH-SY5Y).	Carbachol	47-56	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	94-97
3246807-5	1988	VIP (10(-6) M) inhibited spontaneous and carbachol (10(-8) M)-stimulated propulsive activities of the isolated segment in distal colon.	Carbachol	41-50	VIP peptides	Cavia porcellus	0-3
3404446-3	1988	microM and maximal inhibition at 10(-5) M. Prolactin levels in media were significantly reduced by 30 min of incubation with carbachol.	Carbachol	125-134	prolactin	Rattus norvegicus	43-52
3404446-5	1988	The stimulation of prolactin secretion by 10(-6) M thyrotropin releasing hormone (to 1.5 times control) was inhibited by the addition of carbachol (10(-5) M).	Carbachol	137-146	prolactin	Rattus norvegicus	19-28
2456808-4	1988	Compared to CCh, ACh was a full agonist for contraction but AHR-602 and McN-A-343 were partial agonists producing 80-85% of the maximal response to CCh.	Carbachol	148-151	aryl hydrocarbon receptor	Cavia porcellus	60-63
2456808-5	1988	Similar to previous findings with CCh, tonic contractions produced by AHR-602 and McN-A-343 were less sensitive to inhibition by nifedipine or verapamil than tonic contractions to ACh.	Carbachol	34-37	aryl hydrocarbon receptor	Cavia porcellus	70-73
2456808-10	1988	A concentration of 0.2 mM AHR-602 produced a parallel shift of the concentration-response curve to CCh on inositol phosphate accumulation.	Carbachol	99-102	aryl hydrocarbon receptor	Cavia porcellus	26-29
3390705-2	1988	The maximal carbachol-stimulated [3H]IP1 accumulation in the SH-SY5Y cells was decreased from 51.4 fmol/10(6) cells to 42.4 fmol/10(6) cells (P less than 0.05) and 22.1 fmol/10(6) cells (P less than 0.01) in the absence and presence of 1 microgram/ml and 10 micrograms/ml pertussis toxin, respectively while the EC50 values did not change.	Carbachol	12-21	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	37-40
3342763-5	1988	Intracerebroventricular administration of leumorphin (600 pmol) also reduced the AVP secretion stimulated by icv injection of carbachol (50 pmol).	Carbachol	126-135	arginine vasopressin	Rattus norvegicus	81-84
2898507-5	1988	Cholecystokinin (10(-9) M) and carbachol (10(-5) M) efficiently stimulated lipase secretion (3 fold over basal rate).	Carbachol	31-40	lipase G, endothelial type	Rattus norvegicus	75-81
2453245-12	1988	CCh and substance P (SP) elicited contractions at ED 15 and vasoactive intestinal polypeptide (VIP) caused a relaxation at ED 16.	Carbachol	0-3	vasoactive intestinal peptide	Rattus norvegicus	60-93
2969821-3	1988	In contrast, ANF markedly and significantly inhibited carbachol-induced NE release in a concentration-dependent manner.	Carbachol	54-63	natriuretic peptide A	Rattus norvegicus	13-16
3420006-2	1988	Results of these studies indicate that norepinephrine and carbachol evoke pharmacologically and temporally distinctive patterns of antral gastrin release.	Carbachol	58-67	gastrin	Rattus norvegicus	138-145
3420006-3	1988	Dose-response experiments indicate that norepinephrine is approximately 10,000 times more potent on a molar basis than carbachol in stimulating antral gastrin release.	Carbachol	119-128	gastrin	Rattus norvegicus	151-158
2840296-0	1988	5-HT1A receptor agonists inhibit carbachol-induced stimulation of phosphoinositide turnover in the rat hippocampus.	Carbachol	33-42	5-hydroxytryptamine receptor 1A	Rattus norvegicus	0-6
2452098-1	1988	The increased insulin release induced by carbamoylcholine (CbCh) in pancreatic islets requires the presence of extracellular Ca2+.	Carbachol	41-57	insulin	Homo sapiens	14-21
2452098-1	1988	The increased insulin release induced by carbamoylcholine (CbCh) in pancreatic islets requires the presence of extracellular Ca2+.	Carbachol	59-63	insulin	Homo sapiens	14-21
2450590-3	1988	However, VIP and 8-bromo-cyclic AMP, when added in combination with carbamylcholine, potentiated the stimulation of amylase release to 170-180% of that caused by carbamylcholine alone.	Carbachol	162-177	vasoactive intestinal polypeptide	Mus musculus	9-12
2450590-4	1988	As assessed by two-dimensional gel electrophoresis, VIP reproduced four of the ten changes in protein phosphorylation elicited by carbamylcholine, these changes being the increased phosphorylation of one soluble protein and the decreased phosphorylation of three soluble proteins.	Carbachol	130-145	vasoactive intestinal polypeptide	Mus musculus	52-55
2450590-5	1988	VIP enhanced the carbamylcholine-induced changes in phosphorylation for three proteins.	Carbachol	17-32	vasoactive intestinal polypeptide	Mus musculus	0-3
2450590-10	1988	Moreover, these effects appear to be mediated primarily by VIP-preferring receptors and may be involved in the synergistic action of VIP to promote carbamylcholine-induced amylase release.	Carbachol	148-163	vasoactive intestinal polypeptide	Mus musculus	59-62
2450590-10	1988	Moreover, these effects appear to be mediated primarily by VIP-preferring receptors and may be involved in the synergistic action of VIP to promote carbamylcholine-induced amylase release.	Carbachol	148-163	vasoactive intestinal polypeptide	Mus musculus	133-136
2898270-2	1988	Chlorisondamine, a ganglionic blocking agent, greatly attenuated the induction of TH mRNA levels caused by cold exposure, whereas carbachol and nicotine, cholinergic agonists, increased TH mRNA in control animals.	Carbachol	130-139	tyrosine hydroxylase	Rattus norvegicus	186-188
2897641-5	1988	Further evidence for the cholinergic regulation of the CRH neuron was provided by the findings that both carbachol, a muscarinic receptor agonist, and nicotine, a nicotinic receptor agonist, stimulated IR-rCRH secretion in a dose-dependent fashion.	Carbachol	105-114	corticotropin releasing hormone	Rattus norvegicus	55-58
2452220-7	1988	Also, the calmodulin antagonist drug W7 (N-6-(aminohexyl)-5-chloro-1-naphthalene sulfonamide) inhibited the carbamylcholine-induced release of intracellular Ca2+ in acinar carcinoma cells.	Carbachol	108-123	calmodulin 1	Rattus norvegicus	10-20
3284870-6	1988	Intravenous histamine or carbachol aerosol had similar effects on sRL and Vtr.	Carbachol	25-34	sarcalumenin	Ovis aries	66-69
3338643-2	1988	The release of PP from the dorsal part of the rat pancreas by GRP and carbachol was also studied.	Carbachol	70-79	pancreatic polypeptide	Rattus norvegicus	15-17
3338643-3	1988	Carbachol and GRP stimulated, in a dose-dependent manner ranging from 10(-6) to 10(-9) M, PP secretion from the ventral part of the pancreas.	Carbachol	0-9	pancreatic polypeptide	Rattus norvegicus	90-92
3338643-8	1988	The potency of GRP and vasoactive intestinal polypeptide relative to carbachol at 10(-7) M was 24% and 7%, respectively.	Carbachol	69-78	gastrin releasing peptide	Rattus norvegicus	15-18
3359107-0	1988	Central inhibition by gamma-aminobutyric acid of the release of vasopressin by carbachol in the rat.	Carbachol	79-88	arginine vasopressin	Rattus norvegicus	64-75
2892268-4	1988	Since the muscarinic cholinergic agonists carbachol and muscarine antagonized this current, these results suggest a reciprocal regulation of the M-current by somatostatin and acetylcholine.	Carbachol	42-51	somatostatin	Homo sapiens	158-170
3359107-2	1988	gamma-Aminobutyric acid (GABA) inhibited the antidiuretic response and the increased urinary excretion of vasopressin produced by carbachol when both drugs were injected into a lateral cerebral ventricle (i.c.v.)	Carbachol	130-139	arginine vasopressin	Rattus norvegicus	106-117
3359314-1	1988	The development of carbachol-induced EEG theta (theta) activity was studied in the CA1 and dentate regions of hippocampal formation slices obtained from neonatal rats (4, 6, 8, 10, 12 and 14 days of age).	Carbachol	19-28	carbonic anhydrase 1	Rattus norvegicus	83-86
3342003-2	1988	The cytoplasmic Ca2+ concentration increased from 237 +/- 6 nM to 1580 +/- 170 nM within 3-5 s of addition of 300 microM-carbachol.	Carbachol	121-130	carbonic anhydrase 2	Homo sapiens	16-19
3342003-5	1988	Histamine increased cytoplasmic Ca2+ to about 40% of the maximal value seen with carbachol.	Carbachol	81-90	carbonic anhydrase 2	Homo sapiens	32-35
3342003-7	1988	The increase in Ca2+ in response to either carbachol or histamine could be completely inhibited by pretreating the cells with carbachol; the response to carbachol could be partially inhibited by pretreating the cells with histamine.	Carbachol	43-52	carbonic anhydrase 2	Homo sapiens	16-19
3342003-7	1988	The increase in Ca2+ in response to either carbachol or histamine could be completely inhibited by pretreating the cells with carbachol; the response to carbachol could be partially inhibited by pretreating the cells with histamine.	Carbachol	126-135	carbonic anhydrase 2	Homo sapiens	16-19
3342003-7	1988	The increase in Ca2+ in response to either carbachol or histamine could be completely inhibited by pretreating the cells with carbachol; the response to carbachol could be partially inhibited by pretreating the cells with histamine.	Carbachol	126-135	carbonic anhydrase 2	Homo sapiens	16-19
3342003-10	1988	The results indicate that carbachol and histamine stimulate release of Ca2+ from the same intracellular Ca2+ store, that depletion of this store is responsible for heterologous desensitization between these two agonists, and that repletion of the agonist-sensitive Ca2+ pool does not occur in the continued presence of agonist or in the absence of extracellular Ca2+.	Carbachol	26-35	carbonic anhydrase 2	Homo sapiens	71-74
3342003-10	1988	The results indicate that carbachol and histamine stimulate release of Ca2+ from the same intracellular Ca2+ store, that depletion of this store is responsible for heterologous desensitization between these two agonists, and that repletion of the agonist-sensitive Ca2+ pool does not occur in the continued presence of agonist or in the absence of extracellular Ca2+.	Carbachol	26-35	carbonic anhydrase 2	Homo sapiens	104-107
3342003-10	1988	The results indicate that carbachol and histamine stimulate release of Ca2+ from the same intracellular Ca2+ store, that depletion of this store is responsible for heterologous desensitization between these two agonists, and that repletion of the agonist-sensitive Ca2+ pool does not occur in the continued presence of agonist or in the absence of extracellular Ca2+.	Carbachol	26-35	carbonic anhydrase 2	Homo sapiens	104-107
3342003-10	1988	The results indicate that carbachol and histamine stimulate release of Ca2+ from the same intracellular Ca2+ store, that depletion of this store is responsible for heterologous desensitization between these two agonists, and that repletion of the agonist-sensitive Ca2+ pool does not occur in the continued presence of agonist or in the absence of extracellular Ca2+.	Carbachol	26-35	carbonic anhydrase 2	Homo sapiens	104-107
3242998-3	1988	Intravenous vasopressin antagonist, d(CH2)5 Tyr(Me)AVP, significantly attenuated the pressor response and eliminated the bradycardic response to carbachol in LE rats.	Carbachol	145-154	arginine vasopressin	Rattus norvegicus	12-23
3242998-7	1988	carbachol in normal rats is mediated both by an increase in central sympathetic outflow and in circulating vasopressin.	Carbachol	0-9	arginine vasopressin	Rattus norvegicus	107-118
2450276-4	1988	Upon stimulation with carbamylcholine (CCh) or cholecystokinin (CCK), [Ca2+]i increased within seconds by 4- to 8-fold.	Carbachol	22-37	cholecystokinin	Rattus norvegicus	64-67
3337221-7	1988	The mechanism of chloride secretion induced by histamine resembled that of carbachol, in that both 1) were associated with an increase in free cytosolic calcium, 2) had a site of activation at a basolaterally localized K+ channel, and 3) were potentiated by both cAMP- and cGMP-mediated secretagogues.	Carbachol	75-84	cathelicidin antimicrobial peptide	Homo sapiens	263-268
20501312-2	1988	Increases in the level of c-AMP observed following application of forskolin, isoproterenol and VIP are decreased by carbachol in a dose-dependent manner.	Carbachol	116-125	antimicrobial protein CAP18	Oryctolagus cuniculus	26-31
20501312-2	1988	Increases in the level of c-AMP observed following application of forskolin, isoproterenol and VIP are decreased by carbachol in a dose-dependent manner.	Carbachol	116-125	VIP peptides	Oryctolagus cuniculus	95-98
20501312-4	1988	Carbachol attenuation of elevated c-AMP levels can be inhibited by the muscarinic antagonist atropine but not by the specific muscarinic receptor antagonist pirenzepine.	Carbachol	0-9	antimicrobial protein CAP18	Oryctolagus cuniculus	34-39
2896351-2	1988	Pretreatment of pancreatic acini at 37 degrees C for 120 min with not only pancreatic secretagogues, such as carbachol and bombesin, but also vasoactive intestinal peptide (VIP) and secretin reduced subsequent labeled somatostatin binding to the acinar membranes in a dose-dependent manner.	Carbachol	109-118	somatostatin	Rattus norvegicus	218-230
2896351-7	1988	Furthermore, the inhibitory effect of carbachol was attenuated by the presence of 1 mM EDTA in media for pretreatment, suggesting that intracellular pathways activated by pancreatic secretagogues may be responsible for somatostatin receptor modulation.	Carbachol	38-47	somatostatin	Rattus norvegicus	219-231
2896351-8	1988	Interestingly, when combined with VIP, pretreatment of acini with carbachol produced an additive inhibition of labeled somatostatin binding to the membranes.	Carbachol	66-75	vasoactive intestinal peptide	Rattus norvegicus	34-37
2896351-8	1988	Interestingly, when combined with VIP, pretreatment of acini with carbachol produced an additive inhibition of labeled somatostatin binding to the membranes.	Carbachol	66-75	somatostatin	Rattus norvegicus	119-131
3227877-4	1988	Stimulation of vagotomized rats with pentagastrin and carbachol reduced the levels of thioredoxin and thioredoxin reductase.	Carbachol	54-63	thioredoxin 1	Rattus norvegicus	86-97
3227877-4	1988	Stimulation of vagotomized rats with pentagastrin and carbachol reduced the levels of thioredoxin and thioredoxin reductase.	Carbachol	54-63	peroxiredoxin 5	Rattus norvegicus	102-123
2485249-2	1988	Behavioral analysis of acetylcholine, substance P and corticotropin releasing factor microinjected into the medial anterior cortex revealed a seizure-related "boxing" behavior elicited by carbachol, which was potentiated by coinjection with substance P and antagonized by coinjection with corticotropin releasing factor.	Carbachol	188-197	corticotropin releasing hormone	Rattus norvegicus	54-84
2485249-2	1988	Behavioral analysis of acetylcholine, substance P and corticotropin releasing factor microinjected into the medial anterior cortex revealed a seizure-related "boxing" behavior elicited by carbachol, which was potentiated by coinjection with substance P and antagonized by coinjection with corticotropin releasing factor.	Carbachol	188-197	corticotropin releasing hormone	Rattus norvegicus	289-319
3450542-13	1987	CCK and carbachol in their higher concentrations regulated muscarinic receptor and CCK receptor, respectively.	Carbachol	8-17	cholecystokinin	Homo sapiens	83-86
3435823-3	1987	We demonstrated that neurons in both the CA1 area and dentate gyrus could independently generate carbachol-induced (type 2) electroencephalogram (EEG) theta-activity.	Carbachol	97-106	carbonic anhydrase 1	Homo sapiens	41-44
3678079-9	1987	On the other hand, a subgroup of sarcoidosis patients with raised serum IgE levels had a significantly lower stimulation threshold of the respiratory tract to carbachol.	Carbachol	159-168	immunoglobulin heavy constant epsilon	Homo sapiens	72-75
2446509-2	1987	Acini suspended in pH 7.40 buffer demonstrated cytoplasmic alkalinization of 0.17, 0.14, and 0.15 pH units 2 min after addition of the secretagogues carbachol (10(-5) M), caerulein (10(-10) M), and bromo-A23187 (10(-6) M).	Carbachol	149-158	glucose-6-phosphate isomerase 1	Mus musculus	19-21
2446509-2	1987	Acini suspended in pH 7.40 buffer demonstrated cytoplasmic alkalinization of 0.17, 0.14, and 0.15 pH units 2 min after addition of the secretagogues carbachol (10(-5) M), caerulein (10(-10) M), and bromo-A23187 (10(-6) M).	Carbachol	149-158	glucose-6-phosphate isomerase 1	Mus musculus	98-100
2446509-4	1987	Pretreatment of acini with atropine blocked the pHi rise induced by carbachol; addition of atropine 2 min after the carbachol did not reverse the alkalinization.	Carbachol	68-77	glucose-6-phosphate isomerase 1	Mus musculus	48-51
2446509-8	1987	Net amylase release over 30 min in response to 10(-5) M carbachol was sustained at normal levels in buffers of pH varying between 7.7 and 6.5.	Carbachol	56-65	glucose-6-phosphate isomerase 1	Mus musculus	111-113
2446509-9	1987	In contrast, cytoplasmic alkalinization in response to carbachol occurred only in buffers with pH values between 7.40 and 7.10.	Carbachol	55-64	glucose-6-phosphate isomerase 1	Mus musculus	95-97
3054870-7	1988	By contrast, perifused zein-injected rat pancreases released several times more PP than the controls in response to carbachol stimulation.	Carbachol	116-125	pancreatic polypeptide	Rattus norvegicus	80-82
2446113-3	1987	In the presence of carbamylcholine, which itself increases [3H]phencyclidine binding affinity, substance P caused a decrease in the affinity of [3H]phencyclidine.	Carbachol	19-34	tachykinin 1	Mus musculus	95-106
3450542-16	1987	These effects of CCK and carbachol on receptors were well compatible to the restriction of carbachol or CCK induced amylase secretion by CCK or carbachol.	Carbachol	25-34	cholecystokinin	Homo sapiens	104-107
3450542-16	1987	These effects of CCK and carbachol on receptors were well compatible to the restriction of carbachol or CCK induced amylase secretion by CCK or carbachol.	Carbachol	25-34	cholecystokinin	Homo sapiens	104-107
3450542-16	1987	These effects of CCK and carbachol on receptors were well compatible to the restriction of carbachol or CCK induced amylase secretion by CCK or carbachol.	Carbachol	91-100	cholecystokinin	Homo sapiens	17-20
3450542-16	1987	These effects of CCK and carbachol on receptors were well compatible to the restriction of carbachol or CCK induced amylase secretion by CCK or carbachol.	Carbachol	91-100	cholecystokinin	Homo sapiens	17-20
2890115-2	1987	In the presence of the cholinesterase inhibitor physostigmine, acetylcholine significantly (p less than 0.05-p less than 0.01) stimulated inositol phosphate formation in a concentration-related fashion: carbachol, but not oxotremorine, produced similar effects.	Carbachol	203-212	butyrylcholinesterase	Rattus norvegicus	23-37
2821819-4	1987	Carbachol (0.3 microM) and the phorbol ester PMA (1 microM) potentiate the secretory response to VIP (10 nM), forskolin (3 microM), and dibutyryl adenosine 3",5"-cyclic monophosphate (DBcAMP) (0.5 mM) both in the absence and presence of 2.5 mM extracellular calcium.	Carbachol	0-9	vasoactive intestinal peptide	Rattus norvegicus	97-100
2890115-4	1987	This agent significantly attenuated the stimulatory effect of carbachol on growth hormone (GH) release.	Carbachol	62-71	gonadotropin releasing hormone receptor	Rattus norvegicus	75-89
2889453-4	1987	Cholinergic agonists, metacholine and carbamylcholine, slightly increased the NGF content in quiescent cells, but showed no effects on growing cells.	Carbachol	38-53	nerve growth factor	Mus musculus	78-81
2448658-1	1987	Forskolin, a commonly used adenylate cyclase activator, was found to inhibit reversibly the carbachol-induced ion-translocating capacity of the nicotinic acetylcholine receptor (nAChR) on chick myotubes in a dose- (IC50 = 20 microM) and time-dependent manner.	Carbachol	92-101	cholinergic receptor nicotinic beta 3 subunit	Gallus gallus	144-176
2448658-1	1987	Forskolin, a commonly used adenylate cyclase activator, was found to inhibit reversibly the carbachol-induced ion-translocating capacity of the nicotinic acetylcholine receptor (nAChR) on chick myotubes in a dose- (IC50 = 20 microM) and time-dependent manner.	Carbachol	92-101	cholinergic receptor nicotinic beta 3 subunit	Gallus gallus	178-183
2448658-4	1987	In contrast, in the presence of carbachol, forskolin inhibited (IC50 = 10 microM) the binding of 3H-phencyclidine, a putative nAChR ion-channel ligand, to Torpedo microsac nAChR.	Carbachol	32-41	cholinergic receptor nicotinic beta 3 subunit	Gallus gallus	126-131
2448658-7	1987	In conclusion, forskolin blocks the carbachol-mediated increase in permeability of the nAChR channel by (1) binding to the ion-channel (open state) and (2) generally perturbing the plasma membrane function possibly by interfering with the protein-lipid interface.	Carbachol	36-45	cholinergic receptor nicotinic beta 3 subunit	Gallus gallus	87-92
3651823-1	1987	Carbachol-induced hippocampal EEG theta-rhythms were recorded simultaneously from the CA1 and dentate areas in rat hippocampal brain slices.	Carbachol	0-9	carbonic anhydrase 1	Rattus norvegicus	86-89
2448159-3	1987	Secretion in the presence of submaximal ACTH was potentiated with either 100 microM iso-butylmethylxanthine or 0.3 microM carbachol.	Carbachol	122-131	proopiomelanocortin	Homo sapiens	40-44
2829144-4	1987	Cch (10 microM) inhibits cellular cAMP accumulation and thyroxine (T4) release induced by vasoactive intestinal peptide (VIP), with or without a phosphodiesterase inhibitor.	Carbachol	0-3	vasoactive intestinal peptide	Homo sapiens	121-124
3596169-8	1987	These results suggest that gastrin G is cosecreted with gastrin in response to carbachol and bombesin, and the stimulation of gastrin and gastrin-G secretion by bombesin does not involve cholinergic neural pathways and may reflect a direct action on gastrin cells.	Carbachol	79-88	gastrin	Rattus norvegicus	27-34
3596169-8	1987	These results suggest that gastrin G is cosecreted with gastrin in response to carbachol and bombesin, and the stimulation of gastrin and gastrin-G secretion by bombesin does not involve cholinergic neural pathways and may reflect a direct action on gastrin cells.	Carbachol	79-88	gastrin	Rattus norvegicus	56-63
3596169-8	1987	These results suggest that gastrin G is cosecreted with gastrin in response to carbachol and bombesin, and the stimulation of gastrin and gastrin-G secretion by bombesin does not involve cholinergic neural pathways and may reflect a direct action on gastrin cells.	Carbachol	79-88	gastrin	Rattus norvegicus	56-63
3596169-8	1987	These results suggest that gastrin G is cosecreted with gastrin in response to carbachol and bombesin, and the stimulation of gastrin and gastrin-G secretion by bombesin does not involve cholinergic neural pathways and may reflect a direct action on gastrin cells.	Carbachol	79-88	gastrin	Rattus norvegicus	56-63
3596169-8	1987	These results suggest that gastrin G is cosecreted with gastrin in response to carbachol and bombesin, and the stimulation of gastrin and gastrin-G secretion by bombesin does not involve cholinergic neural pathways and may reflect a direct action on gastrin cells.	Carbachol	79-88	gastrin	Rattus norvegicus	56-63
2442709-1	1987	Three classes of agonists associated with Ca2+-mobilization--alpha 1-adrenergic (methoxamine), muscarinic (carbachol) and peptidergic (substance P, SP)--significantly stimulated the secretion of mucin from enzymatically-dispersed rat submandibular gland acinar cells.	Carbachol	107-116	solute carrier family 13 member 2	Rattus norvegicus	195-200
3037024-6	1987	All three of these monoHETEs were shown also to be inhibitors of the cyclic GMP responses to receptors stimulated by carbachol, histamine, thrombin, neurotensin, and bradykinin.	Carbachol	117-126	5'-nucleotidase, cytosolic II	Mus musculus	76-79
2442709-7	1987	A brief preincubation of cells with carbachol or SP significantly reduced the subsequent isoproterenol (IPR)-provoked secretion of mucin, whereas methoxamine plus IPR stimulated an additive response.	Carbachol	36-45	solute carrier family 13 member 2	Rattus norvegicus	131-136
3496139-1	1987	In human airways synthetic human sequence calcitonin gene-related peptide (hCGRP), a novel peptide produced by alternative processing of mRNA from the calcitonin gene, caused concentration-dependent contraction of human bronchi (EC50 4.9 X 10(-9) M) and was significantly more potent than substance P or carbachol.	Carbachol	304-313	calcitonin related polypeptide alpha	Homo sapiens	75-80
3037217-3	1987	In oligodendrocytes, the greatest stimulation was produced by carbachol with significant increase also produced by bradykinin, histamine and NE.	Carbachol	62-71	kininogen 1	Homo sapiens	115-125
3495533-2	1987	PMA, carbachol, and EGF all stimulated rapid accumulation of mRNA for the proto-oncogenes c-fos and c-myc in the normal cells; in the protein kinase C-deficient cells, carbachol and EGF, but not PMA, retained this effect, which was not mimicked by the calcium ionophore A23187.	Carbachol	5-14	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-95
3495533-2	1987	PMA, carbachol, and EGF all stimulated rapid accumulation of mRNA for the proto-oncogenes c-fos and c-myc in the normal cells; in the protein kinase C-deficient cells, carbachol and EGF, but not PMA, retained this effect, which was not mimicked by the calcium ionophore A23187.	Carbachol	5-14	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	100-105
3495533-2	1987	PMA, carbachol, and EGF all stimulated rapid accumulation of mRNA for the proto-oncogenes c-fos and c-myc in the normal cells; in the protein kinase C-deficient cells, carbachol and EGF, but not PMA, retained this effect, which was not mimicked by the calcium ionophore A23187.	Carbachol	5-14	epidermal growth factor	Homo sapiens	182-185
3495533-2	1987	PMA, carbachol, and EGF all stimulated rapid accumulation of mRNA for the proto-oncogenes c-fos and c-myc in the normal cells; in the protein kinase C-deficient cells, carbachol and EGF, but not PMA, retained this effect, which was not mimicked by the calcium ionophore A23187.	Carbachol	168-177	epidermal growth factor	Homo sapiens	20-23
3495533-5	1987	Both PMA and carbachol promoted the phosphorylation of the ribosomal protein S6 and activated an S6 protein kinase in the normal but not in the protein kinase C-deficient cells.	Carbachol	13-22	ribosomal protein S6	Homo sapiens	59-79
3495533-7	1987	We conclude that, in 1321-N1 cells, induction of c-fos and c-myc mRNA can occur through a protein kinase C-dependent pathway and one or more independent pathways, exemplified by the responses to carbachol and EGF in the protein kinase C-deficient cells.	Carbachol	195-204	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
3495533-7	1987	We conclude that, in 1321-N1 cells, induction of c-fos and c-myc mRNA can occur through a protein kinase C-dependent pathway and one or more independent pathways, exemplified by the responses to carbachol and EGF in the protein kinase C-deficient cells.	Carbachol	195-204	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	59-64
2441609-3	1987	In vitro secretion of lingual lipase and amylase stimulated by the cholinergic agonist, carbamylcholine chloride (carbachol), was 28.3 +/- 1.7, 48.0 +/- 3.2, and 55.9 +/- 2.4% and 18.1 +/- 1.7, 26.4 +/- 3.0, and 28.0 +/- 2.5%, respectively, for 30-, 60-, and 90-min incubations.	Carbachol	88-112	lipase F, gastric type	Rattus norvegicus	22-36
2441609-3	1987	In vitro secretion of lingual lipase and amylase stimulated by the cholinergic agonist, carbamylcholine chloride (carbachol), was 28.3 +/- 1.7, 48.0 +/- 3.2, and 55.9 +/- 2.4% and 18.1 +/- 1.7, 26.4 +/- 3.0, and 28.0 +/- 2.5%, respectively, for 30-, 60-, and 90-min incubations.	Carbachol	114-123	lipase F, gastric type	Rattus norvegicus	22-36
2439077-1	1987	Glucose, forskolin, IBMX and carbachol all stimulated insulin release from freshly obtained human insulinoma cells.	Carbachol	29-38	insulin	Homo sapiens	54-61
2439077-3	1987	On the other hand, of all the insulin secretagogues examined, only carbachol stimulated the formation of 3H-inositol trisphosphate in these cells.	Carbachol	67-76	insulin	Homo sapiens	30-37
3033212-1	1987	The effects of phorbol 12-myristate 13-acetate (PMA) on carbamylcholine (CBC)-induced [3H]cyclic GMP formation in mouse neuroblastoma cells (clone N1E-115) were studied.	Carbachol	56-71	5'-nucleotidase, cytosolic II	Mus musculus	97-100
3033212-1	1987	The effects of phorbol 12-myristate 13-acetate (PMA) on carbamylcholine (CBC)-induced [3H]cyclic GMP formation in mouse neuroblastoma cells (clone N1E-115) were studied.	Carbachol	73-76	5'-nucleotidase, cytosolic II	Mus musculus	97-100
3477639-10	1987	In Ca2+-free bathing media, carbachol produced a transient contraction accompanied by a transient intracellular Ca2+ spike indicating release of Ca2+ from intracellular storage sites.	Carbachol	28-37	carbonic anhydrase 2	Homo sapiens	3-6
3477639-10	1987	In Ca2+-free bathing media, carbachol produced a transient contraction accompanied by a transient intracellular Ca2+ spike indicating release of Ca2+ from intracellular storage sites.	Carbachol	28-37	carbonic anhydrase 2	Homo sapiens	112-115
3477639-10	1987	In Ca2+-free bathing media, carbachol produced a transient contraction accompanied by a transient intracellular Ca2+ spike indicating release of Ca2+ from intracellular storage sites.	Carbachol	28-37	carbonic anhydrase 2	Homo sapiens	112-115
2981050-10	1987	Carbamylcholine (0.5 mM) was the most potent stimulus used evoking early rises in Ins-1,4,5-P3 and Ins-1,3,4,5-P4 (2 s) followed by Ins-1,3,4-P3 (10 s), effects which were only partially dependent on extracellular Ca2+.	Carbachol	0-15	insulin 1	Rattus norvegicus	82-87
3106347-8	1987	The effects of A23187, carbachol, and cholecystokinin on cells preincubated with cholera toxin were abolished by removing extracellular calcium or by adding the calmodulin inhibitor trifluoperazine.	Carbachol	23-32	calmodulin 1	Homo sapiens	161-171
2884697-4	1987	Inclusion of carbachol (2.5 X 10(-6) M) in culture medium increased medium gastrin concentration by 106 +/- 28% (P less than 0.01); addition of specific antibodies to gastrin-releasing peptide to the culture medium did not affect carbachol-stimulated gastrin release.	Carbachol	13-22	gastrin	Rattus norvegicus	75-82
3101510-0	1987	Carbachol regulates cholecystokinin receptor on pancreatic acinar cells.	Carbachol	0-9	cholecystokinin	Rattus norvegicus	20-35
2955256-2	1987	ANF was found to inhibit the carbachol-stimulated synthesis of catecholamines from their labelled [3H]tyrosine precursor in an organ suspension of the rat superior cervical ganglia in vitro.	Carbachol	29-38	natriuretic peptide A	Rattus norvegicus	0-3
2885761-3	1987	Imipramine (4 days) resulted in a marked inhibition of the ability of [D-Ala2, D-Leu5] enkephalin to decrease electrically evoked contractions of the vas deferens (presynaptic opioid receptor response) but did not significantly affect the carbachol-induced increase in electrically evoked contractions (muscarinic receptor response).	Carbachol	239-248	proenkephalin	Rattus norvegicus	87-97
2437768-5	1987	Galanin also impaired the plasma insulin response to either glucose or the cholinergic agonist carbachol.	Carbachol	95-104	galanin and GMAP prepropeptide	Mus musculus	0-7
2435168-1	1987	In dispersed acini from rat pancreas, it was found that bovine pancreatic polypeptide (BPP) and its C-fragment hexapeptide amide (PP-6), at concentrations of 0.1 and 30 microM, respectively, could significantly inhibit amylase secretion stimulated by carbachol (P less than 0.01 or 0.05, respectively), and this inhibition by BPP was dose dependent.	Carbachol	251-260	pancreatic polypeptide	Bos taurus	63-85
2981050-10	1987	Carbamylcholine (0.5 mM) was the most potent stimulus used evoking early rises in Ins-1,4,5-P3 and Ins-1,3,4,5-P4 (2 s) followed by Ins-1,3,4-P3 (10 s), effects which were only partially dependent on extracellular Ca2+.	Carbachol	0-15	insulin 1	Rattus norvegicus	99-104
2981050-10	1987	Carbamylcholine (0.5 mM) was the most potent stimulus used evoking early rises in Ins-1,4,5-P3 and Ins-1,3,4,5-P4 (2 s) followed by Ins-1,3,4-P3 (10 s), effects which were only partially dependent on extracellular Ca2+.	Carbachol	0-15	insulin 1	Rattus norvegicus	99-104
3541715-11	1987	Bradykinin at 10(-4) caused only 21.5 +/- 5.5% of the maximal carbamylcholine contraction in 11 of 18 airways.	Carbachol	62-77	kininogen 1	Homo sapiens	0-10
3329090-5	1987	Glucagon secretion stimulated by the cholinergic agonist carbachol was modestly inhibited by NPY at 4.25 nmol/kg (P less than 0.01) but not affected by CGRP.	Carbachol	57-66	neuropeptide Y	Mus musculus	93-96
3329090-7	1987	Insulin secretion stimulated by carbachol was inhibited by CGRP (P less than 0.01) but not affected by NPY, whereas terbutaline-induced insulin secretion was inhibited by both NPY (P less than 0.05) and CGRP (P less than 0.01).	Carbachol	32-41	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	59-63
3040486-2	1987	Stimulation of muscarinic receptor by carbachol (1 mM) resulted in a decrease in 32Pi incorporation into phosphatidylinositol-4,5-bisphophaphate (TPI) and phosphatidylinositol-4-phosphate (DPI), and an increase in 32Pi incorporation into phosphatidylinositol (PI) and phosphatidic acid (PA), whereas no significant effect on other membrane phospholipids was found.	Carbachol	38-47	triosephosphate isomerase 1	Rattus norvegicus	146-149
3101510-3	1987	Simultaneous addition of carbamylcholine inhibited binding of CCK to acini due to an apparent loss of high affinity CCK binding sites.	Carbachol	25-40	cholecystokinin	Rattus norvegicus	116-119
3101510-8	1987	These findings, at least in part, account for the inhibition of the CCK-induced stimulation of amylase secretion by carbamylcholine.	Carbachol	116-131	cholecystokinin	Rattus norvegicus	68-71
20501187-0	1987	Spontaneous and carbachol-evoked in vivo secretion of acetylcholinesterase from the hippocampus of the rat.	Carbachol	16-25	acetylcholinesterase	Rattus norvegicus	54-74
20501187-2	1987	Local perfusion with 10(?5)M carbachol evoked an increase of 104% in acetylcholinesterase release with no accompanying change in butyrylcholinesterase or lactic dehydrogenase.	Carbachol	29-38	acetylcholinesterase	Rattus norvegicus	69-89
20501187-3	1987	Local or systemic atropine sulphate blocked the carbachol-evoked increase in acetylcholinesterase release, whilst gallamine had no effect.	Carbachol	48-57	acetylcholinesterase	Rattus norvegicus	77-97
20501187-4	1987	Local perfusion of ?-aminobutyric acid (10(?4)M) also blocked the carbachol-evoked release of acetylcholinesterase but had no effect on the spontaneous release.	Carbachol	66-75	acetylcholinesterase	Rattus norvegicus	94-114
3671348-6	1987	The secretion of lipase and colipase from isolated pancreatic acini was also found to parallel a C/L ratio equal to 0.6 in the basal release and to a ratio between 0.5 and 0.6 after stimulation with CCK, secretin, or carbachol.	Carbachol	217-226	lipase G, endothelial type	Rattus norvegicus	17-23
3671348-6	1987	The secretion of lipase and colipase from isolated pancreatic acini was also found to parallel a C/L ratio equal to 0.6 in the basal release and to a ratio between 0.5 and 0.6 after stimulation with CCK, secretin, or carbachol.	Carbachol	217-226	colipase	Rattus norvegicus	28-36
3554168-4	1987	Furthermore, at a low dose level without effect on basal plasma insulin levels, GRP was found to potentiate the insulin response to both glucose (by 40%; p less than 0.05) and to the cholinergic agonist carbachol (by 57%; p less than 0.01).	Carbachol	203-212	gastrin releasing peptide	Mus musculus	80-83
3554168-5	1987	Also, GRP was at this dose level found to potentiate the glucagon response to carbachol (p less than 0.01).	Carbachol	78-87	gastrin releasing peptide	Mus musculus	6-9
3554168-7	1987	Moreover, methylatropine given at a dose level that totally abolishes carbachol-induced insulin secretion inhibited GRP-induced insulin secretion by 39% (p less than 0.05) and GRP-induced glucagon secretion by 25% (p less than 0.01).	Carbachol	70-79	gastrin releasing peptide	Mus musculus	116-119
3101510-1	1987	We have examined the effect of carbamylcholine on the binding of cholecystokinin (CCK) to dispersed acini from rat pancreas.	Carbachol	31-46	cholecystokinin	Rattus norvegicus	65-80
3101510-1	1987	We have examined the effect of carbamylcholine on the binding of cholecystokinin (CCK) to dispersed acini from rat pancreas.	Carbachol	31-46	cholecystokinin	Rattus norvegicus	82-85
3101510-3	1987	Simultaneous addition of carbamylcholine inhibited binding of CCK to acini due to an apparent loss of high affinity CCK binding sites.	Carbachol	25-40	cholecystokinin	Rattus norvegicus	62-65
3569746-2	1986	Gastrin secretion was significantly stimulated by exogenous bombesin at a dose of 10(-8) M. Atropine 10(-6) M, which abolished the action of the cholinergic agent carbachol to stimulate gastrin secretion, had no effect on bombesin-stimulated gastrin secretion.	Carbachol	163-172	gastrin	Rattus norvegicus	0-7
3432293-4	1987	In contrast, a reduction of AChR levels occurs due to prolonged treatment with caffeine or carbamylcholine.	Carbachol	91-106	cholinergic receptor nicotinic delta subunit	Gallus gallus	28-32
3099303-8	1986	Carbocholine injection led to a significant decrease in brain temperature in response to TRH administration.	Carbachol	0-12	thyrotropin releasing hormone	Rattus norvegicus	89-92
3310159-4	1987	On the control day, the dose of carbachol required to reduce the partial expiratory flow volume at 25% of vital capacity (V25p) by at least 25% was established.	Carbachol	32-41	immunoglobulin lambda variable 3-7 (pseudogene)	Homo sapiens	122-126
2435394-3	1986	When cultures were incubated for 3 days with substance P and carbachol, a cholinergic agonist, substance P (10(-6) M, and greater) completely inhibited the increase in tyrosine hydroxylase activity normally induced by carbachol.	Carbachol	61-70	tachykinin precursor 1	Bos taurus	95-106
2435394-3	1986	When cultures were incubated for 3 days with substance P and carbachol, a cholinergic agonist, substance P (10(-6) M, and greater) completely inhibited the increase in tyrosine hydroxylase activity normally induced by carbachol.	Carbachol	218-227	tachykinin precursor 1	Bos taurus	45-56
2435394-3	1986	When cultures were incubated for 3 days with substance P and carbachol, a cholinergic agonist, substance P (10(-6) M, and greater) completely inhibited the increase in tyrosine hydroxylase activity normally induced by carbachol.	Carbachol	218-227	tachykinin precursor 1	Bos taurus	95-106
2435394-4	1986	Long-term stimulation with carbachol also depleted endogenous catecholamines from the cells and substance P prevented this carbachol-induced depletion of catecholamine content.	Carbachol	123-132	tachykinin precursor 1	Bos taurus	96-107
3569746-2	1986	Gastrin secretion was significantly stimulated by exogenous bombesin at a dose of 10(-8) M. Atropine 10(-6) M, which abolished the action of the cholinergic agent carbachol to stimulate gastrin secretion, had no effect on bombesin-stimulated gastrin secretion.	Carbachol	163-172	gastrin	Rattus norvegicus	186-193
3569746-2	1986	Gastrin secretion was significantly stimulated by exogenous bombesin at a dose of 10(-8) M. Atropine 10(-6) M, which abolished the action of the cholinergic agent carbachol to stimulate gastrin secretion, had no effect on bombesin-stimulated gastrin secretion.	Carbachol	163-172	gastrin	Rattus norvegicus	242-249
3022747-4	1986	In rat striatal slices carbachol significantly inhibited the VIP-stimulated increase in cyclic AMP.	Carbachol	23-32	vasoactive intestinal peptide	Rattus norvegicus	61-64
3791067-2	1986	Choline acetyltransferase (ChAT) activity was measured radiometrically using [1-14C]acetyl-coenzyme A as the substrate, muscarinic binding was assayed with [3H]quinuclidinyl benzilate, and the proportion of binding associated with high affinity agonist sites was measured by carbamylcholine displacement of the radioligand.	Carbachol	275-290	choline O-acetyltransferase	Homo sapiens	27-31
3782086-6	1986	In contrast, both variants of desmin, synemin, caldesmon, and 5 cytosolic proteins are phosphorylated at varying rates and remain phosphorylated for the duration of carbachol action.	Carbachol	165-174	desmin	Bos taurus	30-36
3782086-6	1986	In contrast, both variants of desmin, synemin, caldesmon, and 5 cytosolic proteins are phosphorylated at varying rates and remain phosphorylated for the duration of carbachol action.	Carbachol	165-174	synemin	Bos taurus	38-45
2877911-1	1986	Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release.	Carbachol	70-79	gastrin	Rattus norvegicus	0-7
3094467-8	1986	Since carbachol, CCK-8, and A23187, which are believed to act via calcium-calmodulin, also stimulated pepsinogen secretion, this system, too, presumably plays a substantial role.	Carbachol	6-15	pepsin II-2/3	Oryctolagus cuniculus	102-112
2428936-2	1986	In the presence of 1 mM 3-isobutyl-1-methylxanthine, dopamine D-2, muscarinic cholinergic, and opiate receptor stimulation by RU 24926, carbachol, and morphine (all at 10(-8)-10(-5) M), respectively, inhibited the increase in cyclic AMP accumulation in slices of rat striatum due to dopamine D-1 receptor stimulation by 1 microM SKF 38393.	Carbachol	136-145	solute carrier family 3 member 1	Rattus norvegicus	62-110
2879748-6	1986	Ba2+ (2 mM) also stimulated the releases of VIP-LI and CA from the adrenal gland Carbachol (10(-4)M) stimulated CA secretion as much as high potassium and Ba2+, but the magnitude of VIP-LI release was lower.	Carbachol	81-90	vasoactive intestinal peptide	Bos taurus	44-47
2879748-6	1986	Ba2+ (2 mM) also stimulated the releases of VIP-LI and CA from the adrenal gland Carbachol (10(-4)M) stimulated CA secretion as much as high potassium and Ba2+, but the magnitude of VIP-LI release was lower.	Carbachol	81-90	vasoactive intestinal peptide	Bos taurus	182-185
2435897-5	1986	Methionine enkephalin ([Met]-enkephalin) blocked the actions of all the above peptides as well as the effects of DL-octopamine and carbachol.	Carbachol	131-140	proopiomelanocortin	Homo sapiens	24-39
2435394-7	1986	These results indicate that substance P"s effects are relatively specific for the carbachol-induced increased in tyrosine hydroxylase activity and that the primary site of action of substance P is not a site common to the mechanism of tyrosine hydroxylase induction by carbachol and 8-bromoadenosine 3":5"-cyclic monophosphate.	Carbachol	82-91	tachykinin precursor 1	Bos taurus	28-39
2435394-7	1986	These results indicate that substance P"s effects are relatively specific for the carbachol-induced increased in tyrosine hydroxylase activity and that the primary site of action of substance P is not a site common to the mechanism of tyrosine hydroxylase induction by carbachol and 8-bromoadenosine 3":5"-cyclic monophosphate.	Carbachol	269-278	tachykinin precursor 1	Bos taurus	28-39
3779216-4	1986	In guinea-pig taenia, harmaline inhibited the 45.4 mM K+-induced contraction with an IC50 of 6.8 X 10(-5) M and the carbachol (10(-6) M)-induced contraction with an IC50 of 7.0 X 10(-5) M. The inhibitory effects on both high K+- and carbachol-induced contractions were antagonized by raising the external Ca2+ concentrations but not by Bay K 8644.	Carbachol	116-125	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	305-308
2877911-1	1986	Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release.	Carbachol	70-79	gastrin	Rattus norvegicus	169-176
3535012-6	1986	Carbachol (250 micrograms subcutaneously) increased PP release by 62% but did not affect the other hormones.	Carbachol	0-9	familial progressive hyperpigmentation 1	Homo sapiens	52-54
2877911-1	1986	Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release.	Carbachol	70-79	gastrin	Rattus norvegicus	331-338
2877911-1	1986	Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release.	Carbachol	70-79	gastrin	Rattus norvegicus	388-395
2877911-1	1986	Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release.	Carbachol	306-315	gastrin	Rattus norvegicus	0-7
2877911-1	1986	Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release.	Carbachol	306-315	gastrin	Rattus norvegicus	169-176
3741886-3	1986	Carbachol, histamine, gastrin and CCK-8 increased parietal cell [Ca2+]i with the response to carbachol greater than CCK -8 = histamine = gastrin.	Carbachol	0-9	gastrin	Homo sapiens	137-144
3755789-7	1986	NEM at 30 microM enhanced the carbamylcholine stimulated labeling of phosphatidic acid from 32Pi in nerve endings from rat forebrain, suggesting that the low affinity M2-AChr may mediate at least a part of the inositide response to cholinergic stimulation.	Carbachol	30-45	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	170-174
3015710-7	1986	Carbachol inhibited L-tryptophan-stimulated cholecystokinin release in a dose-dependent manner.	Carbachol	0-9	cholecystokinin	Canis lupus familiaris	44-59
3015710-11	1986	Stimulated cholecystokinin release is inhibited by the muscarinic agonist carbachol.	Carbachol	74-83	cholecystokinin	Canis lupus familiaris	11-26
3093455-2	1986	Cholinergic airway responsiveness was determined by measuring the carbachol dose required to increase specific lung resistance (sRL) 150% (i.e., PC150).	Carbachol	66-75	sarcalumenin	Ovis aries	128-131
3741886-3	1986	Carbachol, histamine, gastrin and CCK-8 increased parietal cell [Ca2+]i with the response to carbachol greater than CCK -8 = histamine = gastrin.	Carbachol	93-102	gastrin	Homo sapiens	22-29
3741886-11	1986	13, G814-G823) we conclude that: carbachol, CCK-8, gastrin and histamine increase parietal cell [Ca2+]i initially by release of Ca2+ from the same intracellular store(s); the release of [Ca2+]i in response to carbachol and CCK-8 in both chief and parietal cells appear to be mediated by IP3; however, other mechanisms may be involved in histamine-induced release of parietal cell Ca2+.	Carbachol	209-218	gastrin	Homo sapiens	51-58
2426956-7	1986	Raising intracellular Ca2+ by the calcium ionophore A23187 evoked the same pattern of Cl- loss and O2 uptake as carbachol.	Carbachol	112-121	carbonic anhydrase 2	Rattus norvegicus	22-25
2426956-9	1986	Carbachol raises intracellular Ca2+, causing an increased Cl- permeability of the luminal membrane, resulting in a net Cl- efflux.	Carbachol	0-9	carbonic anhydrase 2	Rattus norvegicus	31-34
2874742-1	1986	Intracerebroventricular (icv) administration of carbachol into conscious rats evoked a substantial increase in vasopressin secretion and blood pressure in a dose-dependent manner.	Carbachol	48-57	arginine vasopressin	Rattus norvegicus	111-122
3525125-9	1986	At this dose level, CGRP inhibited the insulin secretory response to carbachol, leaving that to glucose unaffected.	Carbachol	69-78	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	20-24
3017442-4	1986	Adrenocortical spermidine N1-acetyltransferase was also induced by carbamylcholine, 2-deoxyglucose, apomorphine and piribedil, drugs that are known to cause induction of ornithine decarboxylase in that organ.	Carbachol	67-82	ornithine decarboxylase 1	Rattus norvegicus	170-193
2873868-2	1986	The present work shows that 2-amino-7-phosphonoheptanoic acid (2-APH), a specific antagonist of receptors activated by n-methyl-D-aspartic acid (NMDA), when microinjected into DPC reduces the incidence of clonic seizures elicited by bicuculline, carbachol or kainic acid microinjected into the same site.	Carbachol	246-255	acylaminoacyl-peptide hydrolase	Homo sapiens	65-68
3530597-0	1986	Stimulation by glucose and carbamylcholine of phospholipase A2 in pancreatic islets.	Carbachol	27-42	phospholipase A2 group IB	Homo sapiens	46-62
2431178-0	1986	[Effect of CDP-choline on the action of cholecystokinin and carbachol to stimulate amylase secretion from dispersed rat pancreatic acini].	Carbachol	60-69	cut-like homeobox 1	Rattus norvegicus	11-14
3018477-5	1986	Carbachol mediated cyclic GMP formation with an equilibrium dissociation constant (KD) of 325 microM and cyclic AMP reductions with a KD value of 13 microM.	Carbachol	0-9	5'-nucleotidase, cytosolic II	Mus musculus	26-29
3014395-1	1986	Stimulation of cholinergic fibers or bath application of carbachol (0.1-10 microM) induced a slow excitability increase in CA3 neurons and dentate granule cells of hippocampal slices.	Carbachol	57-66	carbonic anhydrase 3	Cavia porcellus	123-126
2871836-4	1986	Isoproterenol, a beta-adrenergic agonist, and carbachol, a cholinergic agonist produced a 3-fold increase in plasma ANF levels which were constant until the end of the infusion period.	Carbachol	46-55	natriuretic peptide A	Rattus norvegicus	116-119
3742153-0	1986	The hypothermic action of carbachol in the rat brain periaqueductal grey area may involve neurotensin.	Carbachol	26-35	neurotensin	Rattus norvegicus	90-101
3768572-3	1986	Airway responsiveness to carbachol was determined prior to and 24 h after antigen challenge by measuring specific lung resistance (sRL) after administering increasing doses of carbachol aerosol (0.5, 1 and 2.5% w/v) and determining the concentration of carbachol needed to increase sRL 150% over baseline (PC150).	Carbachol	25-34	sarcalumenin	Ovis aries	131-134
3768572-3	1986	Airway responsiveness to carbachol was determined prior to and 24 h after antigen challenge by measuring specific lung resistance (sRL) after administering increasing doses of carbachol aerosol (0.5, 1 and 2.5% w/v) and determining the concentration of carbachol needed to increase sRL 150% over baseline (PC150).	Carbachol	25-34	sarcalumenin	Ovis aries	282-285
3084483-7	1986	The criteria for the receptor-Ni interaction, i.e. carbachol stimulation of the activities of Ni and the GTP gamma S effect on carbachol binding, were no longer observed, when this IAP-treated Ni, instead of the nontreated Ni, was reconstituted into vesicles, though there was no difference between IAP-treated and nontreated Ni in their basal activities observable without carbachol.	Carbachol	51-60	Cd47 molecule	Rattus norvegicus	181-184
3084483-7	1986	The criteria for the receptor-Ni interaction, i.e. carbachol stimulation of the activities of Ni and the GTP gamma S effect on carbachol binding, were no longer observed, when this IAP-treated Ni, instead of the nontreated Ni, was reconstituted into vesicles, though there was no difference between IAP-treated and nontreated Ni in their basal activities observable without carbachol.	Carbachol	127-136	Cd47 molecule	Rattus norvegicus	181-184
3084483-7	1986	The criteria for the receptor-Ni interaction, i.e. carbachol stimulation of the activities of Ni and the GTP gamma S effect on carbachol binding, were no longer observed, when this IAP-treated Ni, instead of the nontreated Ni, was reconstituted into vesicles, though there was no difference between IAP-treated and nontreated Ni in their basal activities observable without carbachol.	Carbachol	127-136	Cd47 molecule	Rattus norvegicus	181-184
3700408-5	1986	Stimulation by carbamylcholine, nicotine, 56 mM K+, or 2 mM Ba2+ led to the incorporation of 32P into a 37-kDa protein that had previously been characterized as a substrate for protein kinase C in vitro (chromobindin 9, or CB9; Summers, T. A., and Creutz, C. E. (1985) J. Biol.	Carbachol	15-30	annexin A1	Homo sapiens	204-218
3009779-3	1986	Adenosine (10(-6) M) inhibited the actions of histamine (10(-14) M) and gastrin (2.5 X 10(-12) M) by 69 and 67%, respectively, but not that of dibutyryl cyclic AMP (10(-16) M) or carbachol (10(-9) M).	Carbachol	179-188	gastrin	Cavia porcellus	72-79
3724745-0	1986	Two components of carbamylcholine-induced loss of nicotinic acetylcholine receptor function in the neuronal cell line PC12.	Carbachol	18-33	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	50-82
2871836-8	1986	This suggests that the rise in plasma ANF induced by isoproterenol and carbachol may be secondary to hemodynamic changes and not to direct receptor stimulation, and may play a role in the observed natriuresis.	Carbachol	71-80	natriuretic peptide A	Rattus norvegicus	38-41
2869695-3	1986	Inclusion of carbachol (2.5 X 10(-6) M) in the culture medium increased media gastrin concentrations from 3.29 +/- 0.76 (SE) (control) to 6.77 +/- 0.76 ng/mg tissue prot (P less than 0.02).	Carbachol	13-22	gastrin	Rattus norvegicus	78-85
2869695-4	1986	Rat antral mucosa was then incubated in the presence of GIP (10(-10) to 10(-7) M) to determine its effect on carbachol-stimulated gastrin release.	Carbachol	109-118	gastric inhibitory polypeptide	Rattus norvegicus	56-59
2869695-4	1986	Rat antral mucosa was then incubated in the presence of GIP (10(-10) to 10(-7) M) to determine its effect on carbachol-stimulated gastrin release.	Carbachol	109-118	gastrin	Rattus norvegicus	130-137
2869695-5	1986	GIP significantly inhibited carbachol-stimulated gastrin release into the culture media at all concentrations examined.	Carbachol	28-37	gastric inhibitory polypeptide	Rattus norvegicus	0-3
2869695-5	1986	GIP significantly inhibited carbachol-stimulated gastrin release into the culture media at all concentrations examined.	Carbachol	28-37	gastrin	Rattus norvegicus	49-56
2869695-6	1986	To determine whether inhibition of carbachol-stimulated gastrin release by GIP was mediated by somatostatin, antral mucosa was incubated in the presence of carbachol, GIP (10(-10) to 10(-7) M), and specific antibodies to somatostatin in excess.	Carbachol	35-44	gastrin	Rattus norvegicus	56-63
2869695-6	1986	To determine whether inhibition of carbachol-stimulated gastrin release by GIP was mediated by somatostatin, antral mucosa was incubated in the presence of carbachol, GIP (10(-10) to 10(-7) M), and specific antibodies to somatostatin in excess.	Carbachol	35-44	gastric inhibitory polypeptide	Rattus norvegicus	75-78
2869695-7	1986	Inclusion of antibodies to somatostatin in the culture medium abolished the capacity of GIP (10(9) to 10(-7) M) to inhibit carbachol-stimulated gastrin release.	Carbachol	123-132	gastric inhibitory polypeptide	Rattus norvegicus	88-91
2869695-7	1986	Inclusion of antibodies to somatostatin in the culture medium abolished the capacity of GIP (10(9) to 10(-7) M) to inhibit carbachol-stimulated gastrin release.	Carbachol	123-132	gastrin	Rattus norvegicus	144-151
2869695-8	1986	Results of these studies indicate 1) that GIP inhibits carbachol-stimulated gastrin release and 2) that, under the conditions of these experiments, GIP inhibition of gastrin release may be mediated locally through release of antral somatostatin.	Carbachol	55-64	gastric inhibitory polypeptide	Rattus norvegicus	42-45
2869695-8	1986	Results of these studies indicate 1) that GIP inhibits carbachol-stimulated gastrin release and 2) that, under the conditions of these experiments, GIP inhibition of gastrin release may be mediated locally through release of antral somatostatin.	Carbachol	55-64	gastrin	Rattus norvegicus	76-83
3958790-0	1986	Loss of acetylcholine receptor clusters induced by treatment of cultured rat myotubes with carbachol.	Carbachol	91-100	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	8-30
3958790-1	1986	Prolonged exposure to carbachol disrupts the acetylcholine receptor (AChR) clusters of cultured rat myotubes without causing myotube loss.	Carbachol	22-31	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	45-67
3958790-1	1986	Prolonged exposure to carbachol disrupts the acetylcholine receptor (AChR) clusters of cultured rat myotubes without causing myotube loss.	Carbachol	22-31	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	69-73
3958790-6	1986	These results are consistent with the idea that cluster loss caused by carbachol and other receptor agonists results from their interaction with the AChR, and the consequent influx of cations into the myotubes.	Carbachol	71-80	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	149-153
3958790-7	1986	Several experiments suggest that extracellular Na+ and Ca2+ are required, and that at least Na+ must permeate the AChR ion channel for full cluster loss to occur in the presence of carbachol.	Carbachol	181-190	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	114-118
3954930-4	1986	The difference in the time-course of responses to acetylcholine and carbachol may be attributed to differences in the susceptibility of the two drugs to metabolism by acetylcholinesterase; carbachol, unlike acetylcholine, being virtually immune to metabolism by this enzyme.	Carbachol	68-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-187
3954930-4	1986	The difference in the time-course of responses to acetylcholine and carbachol may be attributed to differences in the susceptibility of the two drugs to metabolism by acetylcholinesterase; carbachol, unlike acetylcholine, being virtually immune to metabolism by this enzyme.	Carbachol	189-198	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-187
3003156-5	1986	The carbachol-induced increase in Isc was potentiated by either prostaglandin E1 (PGE1) or vasoactive intestinal polypeptide (VIP), agents that act by increasing cAMP.	Carbachol	4-13	vasoactive intestinal peptide	Homo sapiens	91-124
3003156-5	1986	The carbachol-induced increase in Isc was potentiated by either prostaglandin E1 (PGE1) or vasoactive intestinal polypeptide (VIP), agents that act by increasing cAMP.	Carbachol	4-13	vasoactive intestinal peptide	Homo sapiens	126-129
3003156-10	1986	Carbachol"s effect on Cl- secretion is greatly augmented in the presence of VIP or PGE1, which open a cAMP-sensitive Cl- channel on the apical membrane, accounting for a potentiated response.	Carbachol	0-9	vasoactive intestinal peptide	Homo sapiens	76-79
2868120-2	1986	Using intact cells, we found that although ethanol had no effect on basal levels of cyclic GMP synthesis, it rapidly inhibited in a concentration-dependent manner cyclic GMP synthesis mediated by the agonists histamine (histamine H1 receptor) and carbachol (low-affinity muscarinic receptor) and by ionophore X537A and melittin, agents which bypass these receptors.	Carbachol	247-256	5'-nucleotidase, cytosolic II	Mus musculus	170-173
2867688-7	1986	Resting VIP-LI release was enhanced by cholinergic agents (carbachol).	Carbachol	59-68	vasoactive intestinal peptide	Homo sapiens	8-11
3107454-5	1986	In contrast, carbachol, which does not depolarize, elicits Ptd Ins 4,5-P2 hydrolysis, a reaction catalyzed by phospholipase C. The generation of Ins 1,4,5-P3 in this instance is Ca2+ independent, but appears to involve a GTP-binding protein.	Carbachol	13-22	hydroxycarboxylic acid receptor 3	Homo sapiens	221-240
2869808-8	1986	Methylene blue, a drug reported to inhibit guanylate cyclase, in a concentration of 10 microM selectively abolished the relaxation produced by carbachol.	Carbachol	143-152	guanylate cyclase	Bos taurus	43-60
3942871-2	1986	Infusions of eserine or carbachol elicited hippocampal theta activity when made in areas containing high levels of cholinergic markers: the stratum oriens and radiatum of the CA1 and CA3, the stratum moleculare and stratum granulosum of the dentate gyrus and the infragranular region of the hilus.	Carbachol	24-33	carbonic anhydrase 1	Rattus norvegicus	175-178
3942871-2	1986	Infusions of eserine or carbachol elicited hippocampal theta activity when made in areas containing high levels of cholinergic markers: the stratum oriens and radiatum of the CA1 and CA3, the stratum moleculare and stratum granulosum of the dentate gyrus and the infragranular region of the hilus.	Carbachol	24-33	carbonic anhydrase 3	Rattus norvegicus	183-186
3942871-5	1986	Infusions of eserine or carbachol in the vicinity of the hippocampal fissure, the stratum lacunosum/moleculare of the CA1 or CA3, in the deep regions of the hilus, and in the lateral ventricle and overlying neocortex, were also without effect.	Carbachol	24-33	carbonic anhydrase 1	Rattus norvegicus	118-121
3002355-6	1985	Carbachol, which inhibits ADH-induced water flow, also stimulated 32P incorporation into PA and PI.	Carbachol	0-9	arginine vasopressin	Homo sapiens	26-29
2876015-1	1986	Rat antral mucosae maintained for 6 h in organ culture responded to carbamylcholine with a significant increase in endogenous cyclic GMP production and gastrin secretion.	Carbachol	68-83	gastrin	Rattus norvegicus	152-159
2876015-2	1986	The acetylcholine analogue exerted a stimulatory action within a defined concentration range: exposure of antral explants to carbachol concentrations greater than the optimal stimulatory dose was accompanied by a marked decrease in both cyclic GMP production and gastrin release.	Carbachol	125-134	gastrin	Rattus norvegicus	263-270
2418867-8	1985	Treatment of cultures with 5 ng/mL IAP for 24 h completely blocked the stimulation of 86Rb+ efflux evoked by carbachol.	Carbachol	109-118	baculoviral IAP repeat-containing 7 (livin)	Mus musculus	32-38
2414402-0	1985	Effects of substance P on carbachol-stimulated 45Ca2+ uptake into cultured adrenal chromaffin cells.	Carbachol	26-35	tachykinin precursor 1	Bos taurus	11-22
2414402-3	1985	Two effects of substance P were observed: (1) Substance P inhibited carbachol-induced 45Ca2+ uptake and 45Ca2+ efflux and (2) substance P protected against desensitization of carbachol-induced 45Ca2+ uptake and 45Ca2+ efflux.	Carbachol	68-77	tachykinin precursor 1	Bos taurus	15-26
2414402-3	1985	Two effects of substance P were observed: (1) Substance P inhibited carbachol-induced 45Ca2+ uptake and 45Ca2+ efflux and (2) substance P protected against desensitization of carbachol-induced 45Ca2+ uptake and 45Ca2+ efflux.	Carbachol	68-77	tachykinin precursor 1	Bos taurus	46-57
2414402-3	1985	Two effects of substance P were observed: (1) Substance P inhibited carbachol-induced 45Ca2+ uptake and 45Ca2+ efflux and (2) substance P protected against desensitization of carbachol-induced 45Ca2+ uptake and 45Ca2+ efflux.	Carbachol	175-184	tachykinin precursor 1	Bos taurus	15-26
2414402-3	1985	Two effects of substance P were observed: (1) Substance P inhibited carbachol-induced 45Ca2+ uptake and 45Ca2+ efflux and (2) substance P protected against desensitization of carbachol-induced 45Ca2+ uptake and 45Ca2+ efflux.	Carbachol	175-184	tachykinin precursor 1	Bos taurus	126-137
2414402-5	1985	The results also indicate that substance P"s inhibition of net carbachol-induced 45Ca2+ uptake is due to inhibition of 45Ca2+ uptake rather than enhancement of 45Ca2+ efflux.	Carbachol	63-72	tachykinin precursor 1	Bos taurus	31-42
2414402-6	1985	Substance P almost completely inhibited carbachol-induced 45Ca2+ uptake in both Na+-containing and Na+-free media, suggesting that substance P can inhibit the uptake of 45Ca2+ induced by carbachol regardless of whether 45Ca2+ is taken up through voltage-sensitive or acetylcholine receptor-linked channels.	Carbachol	40-49	tachykinin precursor 1	Bos taurus	0-11
2414402-6	1985	Substance P almost completely inhibited carbachol-induced 45Ca2+ uptake in both Na+-containing and Na+-free media, suggesting that substance P can inhibit the uptake of 45Ca2+ induced by carbachol regardless of whether 45Ca2+ is taken up through voltage-sensitive or acetylcholine receptor-linked channels.	Carbachol	40-49	tachykinin precursor 1	Bos taurus	131-142
2414402-6	1985	Substance P almost completely inhibited carbachol-induced 45Ca2+ uptake in both Na+-containing and Na+-free media, suggesting that substance P can inhibit the uptake of 45Ca2+ induced by carbachol regardless of whether 45Ca2+ is taken up through voltage-sensitive or acetylcholine receptor-linked channels.	Carbachol	187-196	tachykinin precursor 1	Bos taurus	0-11
2414402-6	1985	Substance P almost completely inhibited carbachol-induced 45Ca2+ uptake in both Na+-containing and Na+-free media, suggesting that substance P can inhibit the uptake of 45Ca2+ induced by carbachol regardless of whether 45Ca2+ is taken up through voltage-sensitive or acetylcholine receptor-linked channels.	Carbachol	187-196	tachykinin precursor 1	Bos taurus	131-142
2414402-8	1985	In addition, substance P"s inhibition of carbachol-induced 45Ca2+ uptake was noncompetitive with respect to Ca2+, were unable to overcome substance P"s inhibition of [3H]-norepinephrine ( [3H]NE) release.	Carbachol	41-50	tachykinin precursor 1	Bos taurus	13-24
3879308-4	1985	Quinacrine, a phospholipase A2 inhibitor, methylene blue, a guanylate cyclase inhibitor and tetraethylammonium, a potassium permeability inhibitor, inhibited carbachol-induced relaxation and augmented the magnitude of norepinephrine-induced contraction only when endothelium was present.	Carbachol	158-167	phospholipase A2 group IB	Rattus norvegicus	14-30
2415168-8	1985	Thus, the VIP-ergic secretory response in the rat parotid gland is associated with a raised intracellular cyclic AMP level and the mobilisation of a different intracellular Ca2+ pool than that mobilised by carbachol.	Carbachol	206-215	vasoactive intestinal peptide	Rattus norvegicus	10-13
3929859-4	1985	Bradykinin is 1,000-fold more potent than the other agonists tested, which include histamine, norepinephrine, epinephrine, eledoisin-related peptide, arginine-vasopressin, lysine-vasopressin, desmopressin acetate, carbachol, and acetylcholine.	Carbachol	214-223	kininogen 1	Homo sapiens	0-10
3933882-0	1985	Stimulation by glucose and carbamylcholine of phospholipase A2 in pancreatic islets.	Carbachol	27-42	phospholipase A2 group IB	Rattus norvegicus	46-62
3933882-5	1985	These results suggest that carbamylcholine and, to a lesser extent, glucose cause a Ca2+-dependent activation of phospholipase A2 in intact islet cells.	Carbachol	27-42	phospholipase A2 group IB	Rattus norvegicus	113-129
2992293-3	1985	The inhibitory action of carbachol in the absence of isoproterenol and its attenuation by IAP were not associated with any changes in tissue adenosine 3",5"-cyclic monophosphate (cAMP) levels.	Carbachol	25-34	Cd47 molecule	Rattus norvegicus	90-93
3930219-0	1985	Thyrotropin-releasing hormone release from rat pancreas is stimulated by serotonin but inhibited by carbachol.	Carbachol	100-109	thyrotropin releasing hormone	Rattus norvegicus	0-29
3930219-6	1985	Carbachol resulted in a dose-dependent inhibition of TRH release (57% inhibition of release at 10(-8) M; P less than 0.01 compared to control).	Carbachol	0-9	thyrotropin releasing hormone	Rattus norvegicus	53-56
2989329-2	1985	C5a also attenuated carbamyl choline-induced drinking, and carbamyl choline inhibited C5a-induced eating, a mutual inhibition characteristic of the adrenergic-cholinergic interactions at this site.	Carbachol	20-36	complement C5	Rattus norvegicus	0-3
2989329-2	1985	C5a also attenuated carbamyl choline-induced drinking, and carbamyl choline inhibited C5a-induced eating, a mutual inhibition characteristic of the adrenergic-cholinergic interactions at this site.	Carbachol	59-75	complement C5	Rattus norvegicus	86-89
4070020-6	1985	Moreover, a high dose of carbachol could inhibit VIP-induced radioiodine secretion.	Carbachol	25-34	vasoactive intestinal polypeptide	Mus musculus	49-52
4070020-7	1985	Methylatropine did not influence TSH- or VIP-stimulated radioiodine secretion, but counteracted the inhibitory action of carbachol on TSH- and VIP-induced radioiodine release.	Carbachol	121-130	vasoactive intestinal polypeptide	Mus musculus	143-146
2994873-8	1985	Pertussis toxin pretreatment attenuated the inhibitory effects of the muscarinic agents on forskolin-stimulated cyclic AMP synthesis and ACTH secretion as well as the inhibitory effect of carbachol on basal ACTH release.	Carbachol	188-197	pro-opiomelanocortin-alpha	Mus musculus	207-211
4020581-6	1985	From that day on, HDase became sensitive to both pentagastrin and carbachol.	Carbachol	66-75	histidine decarboxylase	Rattus norvegicus	18-23
2984215-1	1985	In PC12 cells, cultured in the presence of nerve growth factor to increase their complement of muscarinic receptors, treatment with carbachol induces muscarinic receptor-dependent rises in free cytosolic Ca2+ as well as hydrolysis of membrane phosphoinositides.	Carbachol	132-141	carbonic anhydrase 2	Rattus norvegicus	204-207
2984215-5	1985	When these cells were then treated with carbachol, their cytosolic concentration of Ca2+ remained at the resting level, whereas inositol-1,4,5-trisphosphate generation was still markedly stimulated.	Carbachol	40-49	carbonic anhydrase 2	Rattus norvegicus	84-87
3883800-0	1985	Carbachol modulates GIP-mediated insulin release from rat pancreatic lobules in vitro.	Carbachol	0-9	gastric inhibitory polypeptide	Rattus norvegicus	20-23
3883800-19	1985	At amino acid concentrations of 21 and 211 mM, but not 2.1 mM, GIP augmented insulin release but again only with carbachol present.	Carbachol	113-122	gastric inhibitory polypeptide	Rattus norvegicus	63-66
3724745-1	1986	Loss of responsiveness of the neuronal-type nicotinic acetylcholine receptor (nAChR) on PC12 cells, a cell line derived from a rat pheochromocytoma, was induced by exposure to carbamylcholine (carbachol).	Carbachol	176-191	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	44-76
3724745-1	1986	Loss of responsiveness of the neuronal-type nicotinic acetylcholine receptor (nAChR) on PC12 cells, a cell line derived from a rat pheochromocytoma, was induced by exposure to carbamylcholine (carbachol).	Carbachol	176-191	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	78-83
3724745-1	1986	Loss of responsiveness of the neuronal-type nicotinic acetylcholine receptor (nAChR) on PC12 cells, a cell line derived from a rat pheochromocytoma, was induced by exposure to carbamylcholine (carbachol).	Carbachol	193-202	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	44-76
3724745-1	1986	Loss of responsiveness of the neuronal-type nicotinic acetylcholine receptor (nAChR) on PC12 cells, a cell line derived from a rat pheochromocytoma, was induced by exposure to carbamylcholine (carbachol).	Carbachol	193-202	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	78-83
2582418-2	1985	BTX enhanced the affinity for the binding of the agonists carbamoylcholine and acetylcholine to the muscarinic receptors in brainstem and ventricle, but not in the cerebral cortex.	Carbachol	58-74	cholinergic receptor nicotinic alpha 7 subunit	Rattus norvegicus	0-3
2582418-4	1985	Guanyl nucleotides, known to induce interconversion of high-affinity agonist binding sites to the low-affinity state, canceled the effect of BTX on carbamoylcholine and acetylcholine binding.	Carbachol	148-164	cholinergic receptor nicotinic alpha 7 subunit	Rattus norvegicus	141-144
4017638-2	1985	Carbamyl-choline and the peptides eledoisin and vasoactive intestinal peptide (VIP) stimulated volume flux as well as secretion of the marker proteins indicating duct cell activation.	Carbachol	0-16	VIP peptides	Oryctolagus cuniculus	79-82
2981284-2	1985	Elevated potassium (56 mM) and carbamylcholine (carbachol, 10(-4) M) cause rapid increases in cyclic AMP levels in the cultures that show a time course similar to that of evoked dopamine release.	Carbachol	31-46	transmembrane serine protease 5	Rattus norvegicus	101-104
2981284-2	1985	Elevated potassium (56 mM) and carbamylcholine (carbachol, 10(-4) M) cause rapid increases in cyclic AMP levels in the cultures that show a time course similar to that of evoked dopamine release.	Carbachol	48-57	transmembrane serine protease 5	Rattus norvegicus	101-104
3999047-1	1985	In adrenalectomized, deoxycorticosterone-treated and normal rats, injection of angiotensin II through a cannula implanted in the preoptic region caused increased intakes of hypertonic NaCl and water when both fluids were available, whereas injection of carbachol through the same cannula only caused increased water intake.	Carbachol	253-262	angiotensinogen	Rattus norvegicus	79-93
2982089-4	1985	Pirenzepine inhibited the [3H]cyclic GMP response to carbachol with a KD value of approximately 6 nM, whereas it inhibited the ability of carbachol to reduce prostaglandin E1-mediated elevations in [3H]cyclic AMP levels with a KD value of 93 nM, thus differentiating between two classes of receptors involved in these responses.	Carbachol	53-62	5'-nucleotidase, cytosolic II	Mus musculus	37-40
2982089-8	1985	These four agonists and bethanecol, which could increase [3H]cyclic GMP levels only 18% as well as acetylcholine, behaved as competitive antagonists in this response to carbachol.	Carbachol	169-178	5'-nucleotidase, cytosolic II	Mus musculus	68-71
2982089-10	1985	The equilibrium dissociation constants for the partial agonists determined by their inhibition of carbachol in the [3H] cyclic GMP response also agreed well with their respective EC50 values for mediating the [3H]cyclic AMP response.	Carbachol	98-107	5'-nucleotidase, cytosolic II	Mus musculus	127-130
2982089-11	1985	Thus, the partial agonists bound to the same receptors at which carbachol mediated [3H]cyclic GMP formation, but with KD values about the same as their respective EC50 values for inhibition of prostaglandin E1-mediated [3H]cyclic AMP increases.	Carbachol	64-73	5'-nucleotidase, cytosolic II	Mus musculus	94-97
2997533-6	1985	Caffeine and carbachol contracted isolated smooth muscle cells and increased intracellular cyclic GMP level.	Carbachol	13-22	5'-nucleotidase, cytosolic II	Homo sapiens	98-101
2578456-8	1985	In the presence of carbamylcholine or cholecystokinin stimulation, the times required for 40% discharge of labeled chymotrypsinogen 2, trypsinogen, amylase, and procarboxypeptidase B were 98, 102, 148, and 180 min, respectively.	Carbachol	19-34	trypsinogen	Cavia porcellus	120-131
2416452-10	1985	This pattern of structural and functional adaptation of acinar cells following secretin infusion corresponds to previously described changes following caerulein and carbamylcholine stimulation.	Carbachol	165-180	secretin	Rattus norvegicus	79-87
2992293-5	1985	The inhibitory action of carbachol on the isoproterenol-induced functional and cAMP responses was also reduced by the IAP treatment.	Carbachol	25-34	Cd47 molecule	Rattus norvegicus	118-121
2992293-6	1985	The increase in tissue guanosine 3",5"-cyclic monophosphate (cGMP) levels produced by carbachol was likewise abolished by the IAP treatment.	Carbachol	86-95	Cd47 molecule	Rattus norvegicus	126-129
2992293-7	1985	These results indicate that IAP treatment attenuates the inhibitory actions of carbachol elicited via muscarinic receptors through both cAMP-dependent and cAMP-independent subcellular processes.	Carbachol	79-88	Cd47 molecule	Rattus norvegicus	28-31
2994150-3	1985	We have reported that lithium ion (Li+) inhibits cyclic GMP formation mediated by the muscarinic receptor agonist, carbachol, in a concentration-dependent manner and that neither ammonium nor sodium ions have such an effect.	Carbachol	115-124	5'-nucleotidase, cytosolic II	Mus musculus	56-59
2857528-3	1985	Carbachol at a dose of 10(-6) M inhibited SLI and stimulated gastrin secretion.	Carbachol	0-9	gastrin	Rattus norvegicus	61-68
2857528-5	1985	Pirenzepine caused a progressive parallel rightward shift in the dose-response curves for SLI inhibition and gastrin stimulation by carbachol, suggesting competitive inhibition.	Carbachol	132-141	gastrin	Rattus norvegicus	109-116
6091776-4	1984	Carbachol produced a steady-state increase of [Ca2+]in and its effect was blocked by atropine and Ca2+ -channel blocking agents.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	47-50
4047976-5	1985	The acetylcholine agonist carbachol, injected directly into the NTS region, effectively mimicked the actions of intraperitoneally administered CCK on feeding and exploration.	Carbachol	26-35	cholecystokinin	Rattus norvegicus	143-146
6098141-6	1984	In carbachol-contracted tracheas with maximally effective concentrations present of adenosine (3 mM), adenine (3 mM) or VIP (23.3 microM), the non-adrenergic neurogenic inhibitory response remained intact.	Carbachol	3-12	VIP peptides	Cavia porcellus	120-123
6149698-6	1984	Carbachol noncompetitively inhibited SLI secretion stimulated by gastrin, epinephrine, and dibutyryl cAMP.	Carbachol	0-9	gastrin	Canis lupus familiaris	65-72
6091776-4	1984	Carbachol produced a steady-state increase of [Ca2+]in and its effect was blocked by atropine and Ca2+ -channel blocking agents.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	98-101
6206899-1	1984	Acetylcholine, oxotremorine and carbachol, compounds that exhibit muscarinic agonist activity, maximally inhibited basal prolactin secretion from GH3 cells by approx.	Carbachol	32-41	prolactin	Rattus norvegicus	121-130
6499920-9	1984	In isolated guinea-pig atria UL-FS 49 antagonized the carbachol-induced bradycardia; a 10-fold shift of the dose-response curve (CA10) was achieved with 11.3 micrograms/ml and the CA10 for AQ-A 39 was 1.7 micrograms/ml.	Carbachol	54-63	carbonic anhydrase-related protein 10	Cavia porcellus	129-133
6499920-9	1984	In isolated guinea-pig atria UL-FS 49 antagonized the carbachol-induced bradycardia; a 10-fold shift of the dose-response curve (CA10) was achieved with 11.3 micrograms/ml and the CA10 for AQ-A 39 was 1.7 micrograms/ml.	Carbachol	54-63	carbonic anhydrase-related protein 10	Cavia porcellus	180-184
6148690-7	1984	A normal [3H]cyclic GMP response to bradykinin and histamine was demonstrated to be present in cells that had lost the [3H]cyclic GMP response to carbachol.	Carbachol	146-155	5'-nucleotidase, cytosolic II	Mus musculus	20-23
3886987-9	1985	Furthermore, the hypothyroid state developed in CCl4-treated rats may provide favorable conditions for the stimulation of DNA synthesis by isoproterenol and carbachol.	Carbachol	157-166	C-C motif chemokine ligand 4	Rattus norvegicus	48-52
6436084-2	1984	In the presence of either divalent cationic chelator (EGTA) or calcium channel blocker (verapamil, nifedipine), carbachol-stimulated gastrin release was inhibited completely to values that were not significantly different from non-stimulated control.	Carbachol	112-121	gastrin	Rattus norvegicus	133-140
6436084-3	1984	In the absence of added calcium chloride, carbachol stimulated gastrin release during the initial 30 min of culture but not at 69 and 120 min of culture.	Carbachol	42-51	gastrin	Rattus norvegicus	63-70
6436084-4	1984	Inhibition by EGTA and verapamil of carbachol-stimulated gastrin release during the initial 30 min of culture suggests, but does not prove, that these agents may also effect intracellular availability and movement of calcium.	Carbachol	36-45	gastrin	Rattus norvegicus	57-64
6478213-5	1984	We propose that on H-type synapses detergents may perturb a hypothetical molecular interaction between AChE and the acetylcholine receptor (AChR) by which AChE modulates the ability of the AChR to be activated by ACh or carbachol.	Carbachol	220-229	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-107
6478213-5	1984	We propose that on H-type synapses detergents may perturb a hypothetical molecular interaction between AChE and the acetylcholine receptor (AChR) by which AChE modulates the ability of the AChR to be activated by ACh or carbachol.	Carbachol	220-229	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
6331450-1	1984	In neuroblastoma N1E 115 cells, carbachol, histamine and PGE1 elevated cyclic GMP content and, induced the efflux of preloaded 45Ca2+, the release of membrane-bound Ca2+ measured by fluorescent CTC, and the increase in [Ca2+]i as measured by Quin 2 fluorescence.	Carbachol	32-41	5'-nucleotidase, cytosolic II	Mus musculus	78-81
6144613-2	1984	The purpose of this study was to examine further the relationships between gastrin and somatostatin and the effects of the cholinergic agonist carbachol on content and release of gastrin and somatostatin using rat antral mucosa in tissue culture.	Carbachol	143-152	gastrin	Rattus norvegicus	179-186
6144613-2	1984	The purpose of this study was to examine further the relationships between gastrin and somatostatin and the effects of the cholinergic agonist carbachol on content and release of gastrin and somatostatin using rat antral mucosa in tissue culture.	Carbachol	143-152	somatostatin	Rattus norvegicus	191-203
6144613-5	1984	Inclusion of carbachol 2.5 X 10(-6) M in the culture medium decreased medium somatostatin from 1.91 +/- 0.28 (SEM) ng/mg tissue protein to 0.62 +/- 0.12 ng/mg (p less than 0.01), extracted mucosal somatostatin from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (p less than 0.001), and percentage of somatostatin released from 42% +/- 2.6% to 27% +/- 2.2% (p less than 0.01).	Carbachol	13-22	somatostatin	Rattus norvegicus	77-89
6144613-5	1984	Inclusion of carbachol 2.5 X 10(-6) M in the culture medium decreased medium somatostatin from 1.91 +/- 0.28 (SEM) ng/mg tissue protein to 0.62 +/- 0.12 ng/mg (p less than 0.01), extracted mucosal somatostatin from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (p less than 0.001), and percentage of somatostatin released from 42% +/- 2.6% to 27% +/- 2.2% (p less than 0.01).	Carbachol	13-22	somatostatin	Rattus norvegicus	197-209
6144613-5	1984	Inclusion of carbachol 2.5 X 10(-6) M in the culture medium decreased medium somatostatin from 1.91 +/- 0.28 (SEM) ng/mg tissue protein to 0.62 +/- 0.12 ng/mg (p less than 0.01), extracted mucosal somatostatin from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (p less than 0.001), and percentage of somatostatin released from 42% +/- 2.6% to 27% +/- 2.2% (p less than 0.01).	Carbachol	13-22	somatostatin	Rattus norvegicus	197-209
6144613-6	1984	Carbachol also increased culture media gastrin from 14 +/- 2.5 to 27 +/- 3.0 ng/mg protein (p less than 0.01).	Carbachol	0-9	gastrin	Rattus norvegicus	39-46
6144613-8	1984	Incubation with somatostatin antisera, both with and without carbachol, markedly increased culture media concentrations of somatostatin, all of which was effectively bound by antibodies present in the media.	Carbachol	61-70	somatostatin	Rattus norvegicus	123-135
6144613-9	1984	Antibody binding of somatostatin was accompanied by significant increases in culture media gastrin concentrations, both in the presence and in the absence of carbachol.	Carbachol	158-167	somatostatin	Rattus norvegicus	20-32
6326613-5	1984	In addition, EGF was found to suppress H+ formation in the isolated gastric glands, both under resting conditions and after stimulation with histamine, carbachol, or dibutyryl cAMP.	Carbachol	152-161	pro-epidermal growth factor	Oryctolagus cuniculus	13-16
6088825-7	1984	These results indicate that carbachol injected intracerebroventricularly produces vasopressor effects mainly by releasing pituitary hormones, probably vasopressin, and that augmented pressor responses in SHR may be due to excessive release of vasopressin.	Carbachol	28-37	arginine vasopressin	Rattus norvegicus	151-162
6088825-7	1984	These results indicate that carbachol injected intracerebroventricularly produces vasopressor effects mainly by releasing pituitary hormones, probably vasopressin, and that augmented pressor responses in SHR may be due to excessive release of vasopressin.	Carbachol	28-37	arginine vasopressin	Rattus norvegicus	243-254
6200615-9	1984	Contractions evoked by transmural electric field stimulation or pharmacologically with carbachol, noradrenaline, substance P and prostaglandin F2 alpha were equally reduced by VIP 10(-7) mol.	Carbachol	87-96	vasoactive intestinal peptide	Sus scrofa	176-179
6091414-0	1984	Calcium-dependent enhancement by carbachol of the VIP-induced cyclic AMP accumulation in cat submandibular gland.	Carbachol	33-42	vasoactive intestinal peptide	Homo sapiens	50-53
6091414-2	1984	Carbachol was found to potentiate the cyclic AMP increase induced by VIP by an atropine sensitive mechanism.	Carbachol	0-9	vasoactive intestinal peptide	Homo sapiens	69-72
6091414-3	1984	The effect of carbachol on cyclic AMP accumulation was abolished by including EGTA in the incubation medium as was the carbachol mediated potentiation of VIP responses.	Carbachol	14-23	vasoactive intestinal peptide	Homo sapiens	154-157
6091414-3	1984	The effect of carbachol on cyclic AMP accumulation was abolished by including EGTA in the incubation medium as was the carbachol mediated potentiation of VIP responses.	Carbachol	119-128	vasoactive intestinal peptide	Homo sapiens	154-157
6091414-6	1984	The phospholipase A2 inhibitor, mepacrine, tended to decrease carbachol actions.	Carbachol	62-71	phospholipase A2 group IB	Homo sapiens	4-20
6322925-2	1984	Carbachol microinjection into an area surrounding the lateral half of the brachium conjunctivum (parabrachial region, PBR) produced profound suppression of nociceptive responses.	Carbachol	0-9	translocator protein	Homo sapiens	118-121
6322925-4	1984	Carbachol microinjection into the ventral part of PBR resulted in slight suppression of motor responses in addition to profound nociceptive suppression.	Carbachol	0-9	translocator protein	Homo sapiens	50-53
6322925-5	1984	Carbachol-produced analgesia (CPA) observed within PBR blocked supraspinally as well as spinally integrated responses normally elicited by either phasic or tonic noxious stimuli.	Carbachol	0-9	translocator protein	Homo sapiens	51-54
6328953-2	1984	In the rat, IF was localized to the chief cells and its secretion responded most efficaciously to carbachol.	Carbachol	98-107	cobalamin binding intrinsic factor	Rattus norvegicus	12-14
6328953-4	1984	In man, IF secretion derived from the parietal cells and was increasingly enhanced by hexoprenaline, pentagastrin, carbachol, histamine and dbcAMP.	Carbachol	115-124	cobalamin binding intrinsic factor	Rattus norvegicus	8-10
6200315-1	1984	It has been previously shown that carbamylcholine (10(-5) M) decreases TSH-induced cAMP accumulation and hormone secretion in dog thyroid slices.	Carbachol	34-49	cathelicidin antimicrobial peptide	Canis lupus familiaris	83-87
6200315-10	1984	It is concluded that carbamylcholine (10(-5) M) inhibits stimulated thyroid secretion at a step beyond cAMP accumulation by blocking pseudopod formation and not by inhibiting thyroglobulin hydrolysis or hormone diffusion.	Carbachol	21-36	cathelicidin antimicrobial peptide	Canis lupus familiaris	103-107
6204039-5	1984	VIP, IBMX and 8-Br-cyclic AMP, all of which act through or mimic the action of cyclic AMP, potentiated the secretory response to maximal concentrations of CCK, carbamylcholine and the ionophore A23187, all of which act via intracellular calcium.	Carbachol	160-175	vasoactive intestinal polypeptide	Mus musculus	0-3
6584029-4	1984	Similarly, in long-term (10-day) monolayer cultures of cells from four corpora lutea, human chorionic gonadotropin (hCG) (50 ng/ml) and PGE2 stimulated, but none of the adrenergic or cholinergic agents altered, the production of progesterone significantly, except for an inhibitory effect of norepinephrine and carbachol in the presence of 17 beta-estradiol (10(-7)M) added to the culture medium.	Carbachol	311-320	chorionic gonadotropin subunit beta 5	Homo sapiens	92-120
6148690-7	1984	A normal [3H]cyclic GMP response to bradykinin and histamine was demonstrated to be present in cells that had lost the [3H]cyclic GMP response to carbachol.	Carbachol	146-155	5'-nucleotidase, cytosolic II	Mus musculus	130-133
6147816-5	1984	Addition of carbachol (3 microM) potentiated the effects of both secretin and VIP on TH activity.	Carbachol	12-21	secretin	Homo sapiens	65-73
6148102-9	1984	The activity of the plasma membrane-bound guanylate cyclase was about 10-fold enhanced by the nonionic detergent Triton X-100 and high concentrations of lysophosphatidylcholine, but was slightly decreased upon addition of the alpha-cholinergic agonist carbachol.	Carbachol	252-261	guanylate cyclase	Bos taurus	42-59
6322784-3	1984	Two lines of evidence suggest that this effect of cholecystokinin on basal and insulin-stimulated 125I-IGF II binding was mediated via a change in intracellular calcium: (1) the cholinergic agent carbachol inhibited IGF II binding to its receptors; (2) addition of the Ca2+ ionophore A23187 mimicked the effects of CCK8 and carbachol.	Carbachol	196-205	insulin-like growth factor 2	Mus musculus	103-109
6322784-3	1984	Two lines of evidence suggest that this effect of cholecystokinin on basal and insulin-stimulated 125I-IGF II binding was mediated via a change in intracellular calcium: (1) the cholinergic agent carbachol inhibited IGF II binding to its receptors; (2) addition of the Ca2+ ionophore A23187 mimicked the effects of CCK8 and carbachol.	Carbachol	196-205	insulin-like growth factor 2	Mus musculus	216-222
6714311-1	1984	Vasoactive intestinal peptide (VIP) relaxed isolated guinea pig airways contracted with carbamylcholine and isolated pulmonary arteries contracted with prostaglandin F2 alpha.	Carbachol	88-103	VIP peptides	Cavia porcellus	0-29
6714311-1	1984	Vasoactive intestinal peptide (VIP) relaxed isolated guinea pig airways contracted with carbamylcholine and isolated pulmonary arteries contracted with prostaglandin F2 alpha.	Carbachol	88-103	VIP peptides	Cavia porcellus	31-34
6322934-0	1984	Increase of carbamylcholine-induced 22Na+ influx into pheochromocytoma PC12h cells by nerve growth factor.	Carbachol	12-27	nerve growth factor	Rattus norvegicus	86-105
6322934-1	1984	Carbamylcholine (CCh)-induced 22Na+ influx into clonal rat pheochromocytoma PC12h cells increased remarkably by culturing the cells in the presence of nerve growth factor (NGF) at a concentration of 50 ng/ml.	Carbachol	0-15	nerve growth factor	Rattus norvegicus	151-170
6322934-1	1984	Carbamylcholine (CCh)-induced 22Na+ influx into clonal rat pheochromocytoma PC12h cells increased remarkably by culturing the cells in the presence of nerve growth factor (NGF) at a concentration of 50 ng/ml.	Carbachol	0-15	nerve growth factor	Rattus norvegicus	172-175
6322934-1	1984	Carbamylcholine (CCh)-induced 22Na+ influx into clonal rat pheochromocytoma PC12h cells increased remarkably by culturing the cells in the presence of nerve growth factor (NGF) at a concentration of 50 ng/ml.	Carbachol	17-20	nerve growth factor	Rattus norvegicus	151-170
6322934-1	1984	Carbamylcholine (CCh)-induced 22Na+ influx into clonal rat pheochromocytoma PC12h cells increased remarkably by culturing the cells in the presence of nerve growth factor (NGF) at a concentration of 50 ng/ml.	Carbachol	17-20	nerve growth factor	Rattus norvegicus	172-175
6322934-2	1984	After 2-4 days in culture with NGF, the CCh-induced 22Na+ influx into cells was enhanced 3- to 5-fold compared to the influx into NGF-untreated cells.	Carbachol	40-43	nerve growth factor	Rattus norvegicus	31-34
6322934-2	1984	After 2-4 days in culture with NGF, the CCh-induced 22Na+ influx into cells was enhanced 3- to 5-fold compared to the influx into NGF-untreated cells.	Carbachol	40-43	nerve growth factor	Rattus norvegicus	130-133
6322934-5	1984	Besides NGF, epidermal growth factor increased the CCh-induced 22Na+ influx into cells to a lower extent that NGF did.	Carbachol	51-54	nerve growth factor	Rattus norvegicus	8-11
6694115-6	1984	However, in rats infused with carbachol for 2 or 5 days, the vasopressin levels were not significantly different from controls.	Carbachol	30-39	arginine vasopressin	Rattus norvegicus	61-72
6694115-11	1984	injections of carbachol were due to increased sympathetic activity and vasopressin release.	Carbachol	14-23	arginine vasopressin	Rattus norvegicus	71-82
6147816-5	1984	Addition of carbachol (3 microM) potentiated the effects of both secretin and VIP on TH activity.	Carbachol	12-21	vasoactive intestinal peptide	Homo sapiens	78-81
6139724-2	1983	In two of the cell lines (DMS 53, DMS 153) acetylcholine chloride, bethanechol chloride, and carbamylcholine at the concentrations of 10(-3)M to 10(-5)M stimulated secretion of bombesin and calcitonin as measured by RIA.	Carbachol	93-108	gastrin releasing peptide	Homo sapiens	177-185
6394244-11	1984	When intact sheets of epithelium were isolated from adult rat ileum and colon, then maintained in vitro and exposed to 20 microM-carbachol, crypt goblet cells released mucin in response to the secretagogue but goblet cells in in portions of the epithelium derived from villi or mucosal surfaces were unresponsive.	Carbachol	129-138	solute carrier family 13 member 2	Rattus norvegicus	168-173
6418215-7	1983	Carbachol (1 X 10(-6)-10(-3) mol/l) stimulated intrinsic factor secretion, 1 X 10(-3) mol/l being maximally effective (90 +/- 8% above basal).	Carbachol	0-9	cobalamin binding intrinsic factor	Rattus norvegicus	47-63
6197390-2	1983	SP contracted the sphincter and the maximum response was only about 25% of that in the presence of equimolar doses of carbachol.	Carbachol	118-127	tachykinin precursor 1	Bos taurus	0-2
6138366-2	1983	The present studies were directed to examine the effect of secretin on carbachol-stimulated gastrin release and to assess the potential role of somatostatin in mediating this effect.	Carbachol	71-80	secretin	Rattus norvegicus	59-67
6138366-2	1983	The present studies were directed to examine the effect of secretin on carbachol-stimulated gastrin release and to assess the potential role of somatostatin in mediating this effect.	Carbachol	71-80	gastrin	Rattus norvegicus	92-99
6138366-5	1983	Carbachol (2.5 X 10(-6) M) in the culture medium increased gastrin level in the medium from 14.1 +/- 2.5 to 26.9 +/- 3.0 ng/mg tissue protein (P less than 0.02), and decreased somatostatin-like immunoreactivity in the medium from 1.91 +/- 0.28 to 0.62 +/- 0.12 ng/mg (P less than 0.01) and extracted mucosal somatostatin-like immunoreactivity from 2.60 +/- 0.30 to 1.52 +/- 0.16 ng/mg (P less than 0.001).	Carbachol	0-9	gastrin	Rattus norvegicus	59-66
6138366-6	1983	Rat antral mucosa was then cultured in the presence of secretin to determine its effect on carbachol-stimulated gastrin release.	Carbachol	91-100	secretin	Rattus norvegicus	55-63
6138366-6	1983	Rat antral mucosa was then cultured in the presence of secretin to determine its effect on carbachol-stimulated gastrin release.	Carbachol	91-100	gastrin	Rattus norvegicus	112-119
6138366-7	1983	Inclusion of secretin (10(-9)-10(-7) M) inhibited significantly carbachol-stimulated gastrin release into the medium, decreasing gastrin from 26.9 +/- 3.0 to 13.6 +/- 3.2 ng/mg (10(-9) M secretin) (P less than 0.05), to 11.9 +/- 1.7 ng/mg (10(-8) secretin) (P less than 0.02), and to 10.8 +/- 4.0 ng/mg (10(-7) M secretin) (P less than 0.02).	Carbachol	64-73	secretin	Rattus norvegicus	13-21
6138366-7	1983	Inclusion of secretin (10(-9)-10(-7) M) inhibited significantly carbachol-stimulated gastrin release into the medium, decreasing gastrin from 26.9 +/- 3.0 to 13.6 +/- 3.2 ng/mg (10(-9) M secretin) (P less than 0.05), to 11.9 +/- 1.7 ng/mg (10(-8) secretin) (P less than 0.02), and to 10.8 +/- 4.0 ng/mg (10(-7) M secretin) (P less than 0.02).	Carbachol	64-73	gastrin	Rattus norvegicus	85-92
6138366-7	1983	Inclusion of secretin (10(-9)-10(-7) M) inhibited significantly carbachol-stimulated gastrin release into the medium, decreasing gastrin from 26.9 +/- 3.0 to 13.6 +/- 3.2 ng/mg (10(-9) M secretin) (P less than 0.05), to 11.9 +/- 1.7 ng/mg (10(-8) secretin) (P less than 0.02), and to 10.8 +/- 4.0 ng/mg (10(-7) M secretin) (P less than 0.02).	Carbachol	64-73	gastrin	Rattus norvegicus	129-136
6138366-7	1983	Inclusion of secretin (10(-9)-10(-7) M) inhibited significantly carbachol-stimulated gastrin release into the medium, decreasing gastrin from 26.9 +/- 3.0 to 13.6 +/- 3.2 ng/mg (10(-9) M secretin) (P less than 0.05), to 11.9 +/- 1.7 ng/mg (10(-8) secretin) (P less than 0.02), and to 10.8 +/- 4.0 ng/mg (10(-7) M secretin) (P less than 0.02).	Carbachol	64-73	secretin	Rattus norvegicus	187-195
6138366-7	1983	Inclusion of secretin (10(-9)-10(-7) M) inhibited significantly carbachol-stimulated gastrin release into the medium, decreasing gastrin from 26.9 +/- 3.0 to 13.6 +/- 3.2 ng/mg (10(-9) M secretin) (P less than 0.05), to 11.9 +/- 1.7 ng/mg (10(-8) secretin) (P less than 0.02), and to 10.8 +/- 4.0 ng/mg (10(-7) M secretin) (P less than 0.02).	Carbachol	64-73	secretin	Rattus norvegicus	187-195
6138366-7	1983	Inclusion of secretin (10(-9)-10(-7) M) inhibited significantly carbachol-stimulated gastrin release into the medium, decreasing gastrin from 26.9 +/- 3.0 to 13.6 +/- 3.2 ng/mg (10(-9) M secretin) (P less than 0.05), to 11.9 +/- 1.7 ng/mg (10(-8) secretin) (P less than 0.02), and to 10.8 +/- 4.0 ng/mg (10(-7) M secretin) (P less than 0.02).	Carbachol	64-73	secretin	Rattus norvegicus	187-195
6138366-9	1983	To determine whether secretion inhibition of carbachol-stimulated gastrin release was mediated by somatostatin, antral mucosa was cultured with carbachol, secretin (10(-9)-10(-7) M), and antibodies to somatostatin.	Carbachol	45-54	gastrin	Rattus norvegicus	66-73
6138366-10	1983	Inclusion of somatostatin antibodies in the culture medium abolished the capacity of secretin (10(-7) and 10(-8) M) to inhibit carbachol-stimulated gastrin release.	Carbachol	127-136	secretin	Rattus norvegicus	85-93
6138366-10	1983	Inclusion of somatostatin antibodies in the culture medium abolished the capacity of secretin (10(-7) and 10(-8) M) to inhibit carbachol-stimulated gastrin release.	Carbachol	127-136	gastrin	Rattus norvegicus	148-155
6138366-11	1983	Results of these studies indicate (a) that secretin inhibits carbachol-stimulated gastrin release and (b) that under the conditions of these experiments secretin inhibition of gastrin release is mediated, at least in part, locally through release of antral somatostatin.	Carbachol	61-70	secretin	Rattus norvegicus	43-51
6138366-11	1983	Results of these studies indicate (a) that secretin inhibits carbachol-stimulated gastrin release and (b) that under the conditions of these experiments secretin inhibition of gastrin release is mediated, at least in part, locally through release of antral somatostatin.	Carbachol	61-70	gastrin	Rattus norvegicus	82-89
6137958-5	1983	Bombesin and carbachol both evoked a dose-dependent stimulation of gastrin release, beginning at below 10(-10) M (bombesin) and 10(-7) M (carbachol).	Carbachol	13-22	gastrin	Homo sapiens	67-74
6137958-5	1983	Bombesin and carbachol both evoked a dose-dependent stimulation of gastrin release, beginning at below 10(-10) M (bombesin) and 10(-7) M (carbachol).	Carbachol	13-22	gastrin releasing peptide	Homo sapiens	114-122
6137958-5	1983	Bombesin and carbachol both evoked a dose-dependent stimulation of gastrin release, beginning at below 10(-10) M (bombesin) and 10(-7) M (carbachol).	Carbachol	138-147	gastrin releasing peptide	Homo sapiens	0-8
6137958-5	1983	Bombesin and carbachol both evoked a dose-dependent stimulation of gastrin release, beginning at below 10(-10) M (bombesin) and 10(-7) M (carbachol).	Carbachol	138-147	gastrin	Homo sapiens	67-74
6137958-6	1983	Carbachol inhibited the release of somatostatin in a dose-dependent manner, being maximally effective at 10(-6) M and then producing 60% inhibition of somatostatin release.	Carbachol	0-9	somatostatin	Homo sapiens	35-47
6137958-6	1983	Carbachol inhibited the release of somatostatin in a dose-dependent manner, being maximally effective at 10(-6) M and then producing 60% inhibition of somatostatin release.	Carbachol	0-9	somatostatin	Homo sapiens	151-163
6137958-8	1983	These data suggest that the gastrin-stimulating effect of carbachol is partially or totally due to inhibition of somatostatin release, whereas bombesinergic stimulation of gastrin release must work in an independent manner.	Carbachol	58-67	gastrin	Homo sapiens	28-35
6137958-8	1983	These data suggest that the gastrin-stimulating effect of carbachol is partially or totally due to inhibition of somatostatin release, whereas bombesinergic stimulation of gastrin release must work in an independent manner.	Carbachol	58-67	somatostatin	Homo sapiens	113-125
6197722-0	1983	Neurotensin interacts with carbachol, secretin, and caerulein in the stimulation of the exocrine pancreas of the rat in vitro.	Carbachol	27-36	neurotensin	Rattus norvegicus	0-11
6139157-9	1983	Activation of antral motility by stimulation of the abdominal vagus or intraarterial carbachol injections to the antrum increased duodenal IR motilin release in the absence of duodenal motility.	Carbachol	85-94	motilin	Canis lupus familiaris	142-149
6089131-5	1984	The secretory responses induced by carbachol (CCh) at any concentrations were not potentiated but inhibited by simultaneous stimulation of VIP.	Carbachol	35-44	VIP peptides	Cavia porcellus	139-142
6089131-5	1984	The secretory responses induced by carbachol (CCh) at any concentrations were not potentiated but inhibited by simultaneous stimulation of VIP.	Carbachol	46-49	VIP peptides	Cavia porcellus	139-142
6888186-3	1983	VIP in chromaffin cells in culture appears to be contained in a secretory granule pool, since it, like methionine-enkephalin (met-enk) was released into the medium after exposure of cells to nicotine, carbachol, veratridine and elevated potassium in a dose-dependent manner.	Carbachol	201-210	vasoactive intestinal peptide	Bos taurus	0-3
6309912-7	1983	The calmodulin antagonists, trifluoperazine (10(-5) M), pimozide (10(-5) M), and a naphthalenesulfonamide (W-7), inhibited the integrated response to histamine by 54, 56, and 53%, and that of carbamylcholine by 65, 64, and 99%, respectively.	Carbachol	192-207	calmodulin-3	Cavia porcellus	4-14
6309912-9	1983	The action of carbamylcholine is completely dependent upon calcium/calmodulin mediation, supporting the concept that cholinergic actions are mediated via calcium-calmodulin events.	Carbachol	14-29	calmodulin-3	Cavia porcellus	67-77
6309912-9	1983	The action of carbamylcholine is completely dependent upon calcium/calmodulin mediation, supporting the concept that cholinergic actions are mediated via calcium-calmodulin events.	Carbachol	14-29	calmodulin-3	Cavia porcellus	162-172
6197124-1	1983	Propranolol-resistant neurogenic relaxation persisted in (carbachol-contracted) guinea-pig tracheae already relaxed by supramaximal concentrations of vasoactive intestinal polypeptide (VIP).	Carbachol	58-67	VIP peptides	Cavia porcellus	150-183
6193336-6	1983	Carbachol increased the activities of cathepsin D and amylase in ascites and acid phosphatase in pancreatic tissue.	Carbachol	0-9	cathepsin D	Rattus norvegicus	38-49
6197124-1	1983	Propranolol-resistant neurogenic relaxation persisted in (carbachol-contracted) guinea-pig tracheae already relaxed by supramaximal concentrations of vasoactive intestinal polypeptide (VIP).	Carbachol	58-67	VIP peptides	Cavia porcellus	185-188
6189522-7	1983	The inhibition of amylase secretion caused by the butyloxycarbonyl tripeptide of cholecystokinin was reversible and specific for those peptides which interact with the cholecystokinin receptor (i.e., cholecystokinin, caerulein, gastrin); it did not inhibit the actions of bombesin, carbachol, physalaemin, vasoactive intestinal peptide, secretin, PHI, ionophore A23187 or 8-bromo cyclic AMP.	Carbachol	282-291	cholecystokinin	Cavia porcellus	81-96
6318567-8	1983	Stimulation of pepsinogen secretion by carbachol or isoproterenol was not inhibited by DBcGMP nor was the stimulation of acid formation by CCK-like peptides.	Carbachol	39-48	pepsin II-2/3	Oryctolagus cuniculus	15-25
6866010-4	1983	Of the four mcAbs studies only mcAb 5.5, which is directed against the cholinergic site in Torpedo AChR, blocks the binding of alpha-bungarotoxin (alpha-Bgt) to AChR in chick muscle cultures and inhibits carbamylcholine-induced sodium transport in these cells.	Carbachol	204-219	cholinergic receptor nicotinic delta subunit	Gallus gallus	99-103
6301290-1	1983	In dispersed glands from rabbit stomach, pepsinogen secretion was stimulated by carbamylcholine, the C-terminal octapeptide of cholecystokinin (CCK-8), and structurally related peptides physalaemin and A23187 but not by bombesin or histamine.	Carbachol	80-95	pepsin II-2/3	Oryctolagus cuniculus	41-51
6301290-3	1983	Dibutyryl cGMP inhibited the stimulation of pepsinogen secretion caused by cholecystokinin but not that caused by carbamylcholine; atropine inhibited the stimulation of pepsinogen secretion caused by carbamylcholine but not that caused by cholecystokinin.	Carbachol	200-215	pepsin II-2/3	Oryctolagus cuniculus	169-179
6847709-3	1983	Phospholipase A2 inhibitors, such as quinacrine, chloroquine, quinine and p-bromophenacyl bromide, all inhibited the secretion of catecholamines evoked by carbamylcholine in a dose-dependent manner.	Carbachol	155-170	LOC104974671	Bos taurus	0-16
6847709-4	1983	These phospholipase A2 inhibitors also inhibited the cellular uptake of 45Ca2+ evoked by carbamylcholine with similar dose-response curves to those for inhibition of catecholamine secretion.	Carbachol	89-104	LOC104974671	Bos taurus	6-22
6189522-7	1983	The inhibition of amylase secretion caused by the butyloxycarbonyl tripeptide of cholecystokinin was reversible and specific for those peptides which interact with the cholecystokinin receptor (i.e., cholecystokinin, caerulein, gastrin); it did not inhibit the actions of bombesin, carbachol, physalaemin, vasoactive intestinal peptide, secretin, PHI, ionophore A23187 or 8-bromo cyclic AMP.	Carbachol	282-291	cholecystokinin	Cavia porcellus	168-183
6189522-7	1983	The inhibition of amylase secretion caused by the butyloxycarbonyl tripeptide of cholecystokinin was reversible and specific for those peptides which interact with the cholecystokinin receptor (i.e., cholecystokinin, caerulein, gastrin); it did not inhibit the actions of bombesin, carbachol, physalaemin, vasoactive intestinal peptide, secretin, PHI, ionophore A23187 or 8-bromo cyclic AMP.	Carbachol	282-291	cholecystokinin	Cavia porcellus	168-183
6822533-2	1983	The use of two separate assays, specific binding of 125I-alpha-bungarotoxin and carbamylcholine-activated 22Na+ uptake, has allowed us to monitor the effects of impaired glycosylation on the metabolic and functional properties of AChR.	Carbachol	80-95	cholinergic receptor nicotinic delta subunit	Gallus gallus	230-234
6129701-1	1983	Somatostatin, a tetradecapeptide with potent inhibitory actions on gastric acid secretion, potentiated carbamylcholine-induced synthesis and release of prostaglandin E2 from isolated perfused rat stomachs.	Carbachol	103-118	somatostatin	Rattus norvegicus	0-12
6298631-3	1983	However, we report here that after inhibiting AChE in a cholinergic synapse in Aplysia, we found an increase not only in postsynaptic responses to presynaptic stimulation and to ionophoretic application of ACh on postsynaptic receptors, but also to ionophoretic application of carbachol.	Carbachol	277-286	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50
6687224-6	1983	Carbachol bound to the A-promoter-treated membranes with a lower affinity and a higher Hill coefficient, and these kinetic values were not altered by Gpp(NH)p, indicating that treatment of membranes with the A-protomer of IAP uncoupled muscarinic receptors from N. This IAP-sensitive N is Ni involved in the cyclase inhibition.	Carbachol	0-9	Cd47 molecule	Rattus norvegicus	222-225
6309168-2	1983	Carbachol markedly decreased the stimulatory effect of the adenylate cyclase activator, forskolin, on both cyclic AMP formation and ACTH secretion.	Carbachol	0-9	pro-opiomelanocortin-alpha	Mus musculus	132-136
6309168-4	1983	The stimulatory effects of (-) isoproterenol on cyclic nucleotide formation and ACTH secretion were also blocked by carbachol.	Carbachol	116-125	pro-opiomelanocortin-alpha	Mus musculus	80-84
6309168-5	1983	The inhibitory effects of carbachol on (-) isoproterenol-stimulated cyclic AMP synthesis and ACTH secretion were reversed by the muscarinic antagonist, atropine, and not by the nicotinic antagonist, gallamine.	Carbachol	26-35	pro-opiomelanocortin-alpha	Mus musculus	93-97
6297650-2	1983	2 Sixteen of these compounds were assayed for their ability to antagonize carbachol-stimulated cyclic guanosine 3",5"-monophosphate (cyclic GMP) synthesis by intact murine neuroblastoma cells (clone N1E-115).	Carbachol	74-83	5'-nucleotidase, cytosolic II	Homo sapiens	140-143
6687224-6	1983	Carbachol bound to the A-promoter-treated membranes with a lower affinity and a higher Hill coefficient, and these kinetic values were not altered by Gpp(NH)p, indicating that treatment of membranes with the A-protomer of IAP uncoupled muscarinic receptors from N. This IAP-sensitive N is Ni involved in the cyclase inhibition.	Carbachol	0-9	Cd47 molecule	Rattus norvegicus	270-273
6402798-3	1983	Exposure to carbamylcholine, veratridine or high K evokes a transient increase in the rate of catecholamine release in association with dopamine beta hydroxylase but not lactate dehydrogenase.	Carbachol	12-27	dopamine beta-hydroxylase	Bos taurus	136-161
6184589-4	1982	The phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (MIX) enhanced the effects of carbachol on both c-GMP accumulation and amylase release.	Carbachol	91-100	5'-nucleotidase, cytosolic II	Mus musculus	111-114
6127400-9	1982	It is concluded that tyrosine 3-monooxygenase activity in rat superior cervical ganglia can be increased by both nicotinic and muscarinic stimulation, that nicotinic stimulation can produce a greater increase than can muscarinic stimulation and that carbachol increases enzyme activity by a combination of both pathways.	Carbachol	250-259	tyrosine hydroxylase	Rattus norvegicus	21-45
7144436-2	1982	Its activity was demonstrated orally at low dose in pentagastrin stimulated Shay rat and in Heidenhain pouch in dog against gastrin, pentagastrin, carbachol and test meal.	Carbachol	147-156	gastrin	Canis lupus familiaris	57-64
6287866-3	1982	Spontaneous release of pepsinogen was found to be less than 1% of the total per hour and relatively constant for at least 2 h. Pepsinogen release was stimulated in a dose-dependent manner by both carbachol and isoproterenol.	Carbachol	196-205	pepsin II-2/3	Oryctolagus cuniculus	23-33
6287866-3	1982	Spontaneous release of pepsinogen was found to be less than 1% of the total per hour and relatively constant for at least 2 h. Pepsinogen release was stimulated in a dose-dependent manner by both carbachol and isoproterenol.	Carbachol	196-205	pepsin II-2/3	Oryctolagus cuniculus	127-137
6818682-4	1982	In two subjects the effect of intravenously injected TRH, 200 micrograms, and atropine, 500 micrograms, on the carbacholine-stimulated gastric motility was tested.	Carbachol	111-123	thyrotropin releasing hormone	Homo sapiens	53-56
6818682-8	1982	The inhibiting effect of TRH on the carbacholine-stimulated gastric motility was similar to the effect of TRH on the hypoglycemia-stimulated gastric motility.	Carbachol	36-48	thyrotropin releasing hormone	Homo sapiens	25-28
6277122-8	1981	CCK-39 potentiated glucose- as well as carbachol-induced insulin secretion, whereas it did not influence L-IPNA-induced insulin release.	Carbachol	39-48	cholecystokinin	Mus musculus	0-3
6124857-2	1982	In the absence of extracellular sodium isoproterenol-stimulated c-GMP and c-AMP levels were significantly reduced; carbachol-stimulated c-GMP levels were not affected.	Carbachol	115-124	5'-nucleotidase, cytosolic II	Mus musculus	138-141
6177251-4	1982	Concentrations of cholecystokinin that were supramaximal for stimulating enzyme secretion abolished the stimulation caused by other secretagogues that promote mobilization of cellular calcium (e.g., carbamylcholine, bombesin, physalaemin, or A23187), as well as that caused by secretagogues that elevate cellular cAMP (e.g., vasoactive intestinal peptide or secretin).	Carbachol	199-214	cholecystokinin	Homo sapiens	18-33
6177536-0	1982	Carbachol potentiates the cyclic AMP-stimulating effect of VIP in cat submandibular gland.	Carbachol	0-9	VIP peptides	Cavia porcellus	59-62
6177536-4	1982	The addition of carbachol potentiated the cyclic AMP response to VIP in the submandibular acini while no such effect was observed in the pancreas.	Carbachol	16-25	VIP peptides	Cavia porcellus	65-68
6175231-3	1982	Carbamylcholine and the C-terminal octapeptide of cholecystokinin also augmented the action of VIP on amylase secretion from mouse pancreatic acini.	Carbachol	0-15	vasoactive intestinal polypeptide	Mus musculus	95-98
6175231-2	1982	Secretagogues that mobilize cellular calcium (carbamylcholine, C-terminal octapeptide of cholecystokinin, bombesin, or A23187) caused a sevenfold augmentation of the actions of VIP, secretin, or 8-bromo-cAMP on enzyme secretion.	Carbachol	46-61	vasoactive intestinal peptide	Rattus norvegicus	177-180
6175231-2	1982	Secretagogues that mobilize cellular calcium (carbamylcholine, C-terminal octapeptide of cholecystokinin, bombesin, or A23187) caused a sevenfold augmentation of the actions of VIP, secretin, or 8-bromo-cAMP on enzyme secretion.	Carbachol	46-61	secretin	Rattus norvegicus	182-190
6193153-0	1982	The role of cyclic nucleotide phosphodiesterase in the inhibition of cyclic AMP accumulation by carbachol and phosphatidate.	Carbachol	96-105	phosphodiesterase 3B	Homo sapiens	12-47
6289369-5	1982	Epinephrine and carbachol increased plasma cyclic AMP and cyclic GMP levels, respectively, in both C57BL and DBA mice.	Carbachol	16-25	5'-nucleotidase, cytosolic II	Mus musculus	65-68
6171823-4	1981	In contrast, stimuliation by carbachol induced significant phosphorylation of only protein I.	Carbachol	29-38	annexin A2	Mus musculus	83-92
6171823-7	1981	Incubation of mouse parotid gland slices with either 20 microM isoproterenol or 10 microM carbachol resulted in strong and comparable releases of amylase, which were accompanied by comparable phosphorylations of protein I.	Carbachol	90-99	annexin A2	Mus musculus	212-221
6171823-9	1981	Removal of external calcium by ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetate abolished the carbachol-induced release of amylase but not the phosphorylation of protein I.	Carbachol	111-120	annexin A2	Mus musculus	179-188
7127212-6	1982	Atropine eliminated carbachol-induced I gastrin release and motility increases, even in the presence of nerve blockade by tetrodotoxin.	Carbachol	20-29	gastrin	Canis lupus familiaris	40-47
6174546-1	1981	After chemical stimulation with depolarizing agents (Ba2+ or Ca2+/carbachol) isolated living chromaffin cells display a drastically increased binding capacity for anti-DBH, distributed spotwise on or near the outer cell membrane.	Carbachol	66-75	dopamine beta-hydroxylase	Homo sapiens	168-171
6114896-0	1981	Somatostatin inhibition of basal and carbachol-stimulated gastrin release in rat antral organ culture.	Carbachol	37-46	gastrin	Rattus norvegicus	58-65
6114896-4	1981	Gastrin release into the culture media stimulated by the cholinergic agent, carbachol (10(-5) M), was suppressed by somatostatin: at 30 min and 6 h of culture 10(-8) M somatostatin inhibited carbachol-stimulated gastrin release by 66% and 54%, respectively, and 10(-5) M and 10(-4) M somatostatin completely abolished gastrin release.	Carbachol	76-85	gastrin	Rattus norvegicus	0-7
6114896-4	1981	Gastrin release into the culture media stimulated by the cholinergic agent, carbachol (10(-5) M), was suppressed by somatostatin: at 30 min and 6 h of culture 10(-8) M somatostatin inhibited carbachol-stimulated gastrin release by 66% and 54%, respectively, and 10(-5) M and 10(-4) M somatostatin completely abolished gastrin release.	Carbachol	76-85	gastrin	Rattus norvegicus	212-219
6114896-4	1981	Gastrin release into the culture media stimulated by the cholinergic agent, carbachol (10(-5) M), was suppressed by somatostatin: at 30 min and 6 h of culture 10(-8) M somatostatin inhibited carbachol-stimulated gastrin release by 66% and 54%, respectively, and 10(-5) M and 10(-4) M somatostatin completely abolished gastrin release.	Carbachol	76-85	gastrin	Rattus norvegicus	318-325
6114896-4	1981	Gastrin release into the culture media stimulated by the cholinergic agent, carbachol (10(-5) M), was suppressed by somatostatin: at 30 min and 6 h of culture 10(-8) M somatostatin inhibited carbachol-stimulated gastrin release by 66% and 54%, respectively, and 10(-5) M and 10(-4) M somatostatin completely abolished gastrin release.	Carbachol	191-200	gastrin	Rattus norvegicus	0-7
6114896-5	1981	The rate of gastrin release stimulated by carbachol was suppressed significantly by each dose of somatostatin examined (10(-8) M to 10(-4) M).	Carbachol	42-51	gastrin	Rattus norvegicus	12-19
6117505-0	1981	Inhibition by somatostatin of carbamylcholine-induced gastrin and glucagon release from the isolated perfused canine stomach.	Carbachol	30-45	gastrin	Canis lupus familiaris	54-61
6117505-1	1981	At an arterial plasma concentration of 61 nmol/l (100 ng/ml) synthetic cyclic somatostatin completely abolished basal glucagon and gastrin release as well as carbamylcholine-induced glucagon and gastrin release from the isolated perfused dog stomach.	Carbachol	158-173	gastrin	Canis lupus familiaris	195-202
6268193-10	1981	Cimetidine, a histamine H2 receptor antagonist, blocked the [14C]aminopyrine uptake induced either by histamine alone or by the potentiating combination of histamine plus carbachol.	Carbachol	171-180	histamine H2 receptor	Cavia porcellus	14-35
6117361-6	1981	intravenous infusion of carbachol (1 microgram.kg-1.min-1) strongly stimulated luminal somatostatin and gastrin release (from 5 +/- 1 to 192 +/- 52 pg.mL-1 and from 27 +/- 5 to 198 +/- 41 pg.mL-1, respectively) during perfusion with 0.1 M HCl.	Carbachol	24-33	somatostatin	Rattus norvegicus	87-99
6791509-6	1981	Carbachol mimicked both the stimulatory and inhibitory effects of CCK, whereas the Ca2+ ionophore A23187 mimicked only the inhibitory effects.	Carbachol	0-9	cholecystokinin	Rattus norvegicus	66-69
6170412-5	1981	Chlorpromazine, trifluoperazine, thioridazine, chlorprothixene and amitriptyline inhibited amylase secretion stimulated by carbachol, A-23187, and cholecystokinin-pancreozymin but not that elicited by dibutyryl cyclic AMP secretin or vasoactive intestinal peptide (VIP).	Carbachol	123-132	vasoactive intestinal peptide	Homo sapiens	265-268
7223893-7	1981	The data are interpreted to support our assumption that CCK-OP and CCh increase the plasma membrane permeability to Ca2+ in pancreatic acinar cells in addition to their action to initiate release of CA2+ from an intracellular Ca2+ trigger pool.	Carbachol	67-70	carbonic anhydrase 2	Rattus norvegicus	116-119
6117361-6	1981	intravenous infusion of carbachol (1 microgram.kg-1.min-1) strongly stimulated luminal somatostatin and gastrin release (from 5 +/- 1 to 192 +/- 52 pg.mL-1 and from 27 +/- 5 to 198 +/- 41 pg.mL-1, respectively) during perfusion with 0.1 M HCl.	Carbachol	24-33	gastrin	Rattus norvegicus	104-111
6110537-10	1981	Plasma insulin and glucagon rose promptly after carbachol and were unchanged by atropine.	Carbachol	48-57	insulin	Canis lupus familiaris	7-14
6109792-5	1981	Because high carbachol concentrations were needed to produce gastrin secretion, and inhibition by atropine occurred also at high concentrations, these effects may be nonspecific.	Carbachol	13-22	gastrin	Rattus norvegicus	61-68
6109792-6	1981	Both carbachol- and norepinephrine-mediated gastrin release are modified by somatostatin and adenosine.	Carbachol	5-14	gastrin	Rattus norvegicus	44-51
7342828-0	1981	Feeding and growth hormone after cerebroventricular carbachol in sheep.	Carbachol	52-61	somatotropin	Ovis aries	12-26
7223893-7	1981	The data are interpreted to support our assumption that CCK-OP and CCh increase the plasma membrane permeability to Ca2+ in pancreatic acinar cells in addition to their action to initiate release of CA2+ from an intracellular Ca2+ trigger pool.	Carbachol	67-70	carbonic anhydrase 2	Rattus norvegicus	199-202
7223893-7	1981	The data are interpreted to support our assumption that CCK-OP and CCh increase the plasma membrane permeability to Ca2+ in pancreatic acinar cells in addition to their action to initiate release of CA2+ from an intracellular Ca2+ trigger pool.	Carbachol	67-70	carbonic anhydrase 2	Rattus norvegicus	226-229
6159206-8	1980	Carbamylcholine and the ionophore A23187, which can raise cGMP in thyroid slices, inhibited TSH and dibutyryl cAMP induced ODC increases, PGF1 alpha was inhibitory to ODC stimulation.	Carbachol	0-15	ornithine decarboxylase 1	Canis lupus familiaris	123-126
7008812-3	1980	Carbamylcholine has been injected together with captopril, an inhibitor of the enzyme converting angiotensin I into angiotensin II, and with propranolol, which blocks the renin beta-receptors respectively.	Carbachol	0-15	angiotensinogen	Rattus norvegicus	116-130
7008812-3	1980	Carbamylcholine has been injected together with captopril, an inhibitor of the enzyme converting angiotensin I into angiotensin II, and with propranolol, which blocks the renin beta-receptors respectively.	Carbachol	0-15	renin	Rattus norvegicus	171-176
7009286-5	1981	Secretin inhibited insulin secretion induced by carbachol and L-IPNA, whereas VIP potentiated L-IPNA-induced insulin secretion and had no influence on the effect of carbachol.	Carbachol	48-57	secretin	Mus musculus	0-8
6109003-5	1980	Carbamylcholine-, ionophore X-537A-, and sodium azide-induced cyclic GMP formation increased with time in culture to a maximum of 13-, 9-, and 2.5-fold above basal, respectively.	Carbachol	0-15	5'-nucleotidase, cytosolic II	Mus musculus	69-72
6159206-8	1980	Carbamylcholine and the ionophore A23187, which can raise cGMP in thyroid slices, inhibited TSH and dibutyryl cAMP induced ODC increases, PGF1 alpha was inhibitory to ODC stimulation.	Carbachol	0-15	ornithine decarboxylase 1	Canis lupus familiaris	167-170
7380199-1	1980	The purpose of the present study was to examine the effects of the cholinergic agent carbachol on gastrin synthesis and secretion by rat antral mucosa in organ culture.	Carbachol	85-94	gastrin	Rattus norvegicus	98-105
7394323-3	1980	Carbachol-contracted airway smooth muscle relaxed to PGE1, PGE2, isoproterenol, dimaprit (H2-agonist) and bradykinin (BK).	Carbachol	0-9	kininogen 1	Canis lupus familiaris	106-116
7394323-3	1980	Carbachol-contracted airway smooth muscle relaxed to PGE1, PGE2, isoproterenol, dimaprit (H2-agonist) and bradykinin (BK).	Carbachol	0-9	kininogen 1	Canis lupus familiaris	118-120
6245588-2	1980	Each enterocyte possessed approximately 60,000 binding sites and binding of the tracer to these sites could be inhibited by VIP [concentration for half-maximal effect (Kd), 12 nM] and by secretin (Kd greater than 1 micro M), but not by glucagon, gastrin, cholecystokinin, calcitonin, bombesin, litorin, physalaemin, substance P, eledoisin, serotonin, carbamylcholine, or histamine.	Carbachol	351-366	VIP peptides	Cavia porcellus	124-127
7380199-2	1980	In addition, the effect of atropine on basal and carbachol-stimulated gastrin release was investigated.	Carbachol	49-58	gastrin	Rattus norvegicus	70-77
7380199-3	1980	These in vitro studies demonstrate that carbachol stimulated both gastrin secretion and synthesis in a dose-dependent manner.	Carbachol	40-49	gastrin	Rattus norvegicus	66-73
7380199-4	1980	Maximal stimulation of gastrin synthesis and release occurred at a concentration of 1 X 10(-5) M carbachol.	Carbachol	97-106	gastrin	Rattus norvegicus	23-30
7380199-5	1980	The rate of gastrin release stimulated by carbachol (1 X10(-5) M) was 0.79 ng-hr-1-mg-1 which was significantly greater than the control value of 0.37 ng-hr-1 (P less than 0.001).	Carbachol	42-51	gastrin	Rattus norvegicus	12-19
7380199-7	1980	However, carbachol-stimulated gastrin release was inhibited progressively by inclusion of increasing concentrations of atropine in the culture media.	Carbachol	9-18	gastrin	Rattus norvegicus	30-37
7380199-8	1980	The results of these studies indicated that the acetylcholine analogue, carbachol, is capable of directly stimulating the antral gastrin cell to significantly increase the rate of synthesis and release of gastrin.	Carbachol	72-81	gastrin	Rattus norvegicus	129-136
7380199-8	1980	The results of these studies indicated that the acetylcholine analogue, carbachol, is capable of directly stimulating the antral gastrin cell to significantly increase the rate of synthesis and release of gastrin.	Carbachol	72-81	gastrin	Rattus norvegicus	205-212
7380199-9	1980	Whereas atropine, under these in vitro conditions, does not alter basal gastrin release, the muscarinic antagonist does competively inhibit carbachol-stimulated gastrin secretion.	Carbachol	140-149	gastrin	Rattus norvegicus	161-168
6965318-0	1980	Antibody to Thy-1 antigen injected into rat hypothalamus selectively inhibits carbamyl choline induced drinking.	Carbachol	78-94	Thy-1 cell surface antigen	Rattus norvegicus	12-25
6246192-4	1980	Voltage- jump relaxations follow an exponential time-course; the rate constants are about twice as large as those seen with 50 muM carbachol and have the same voltage and temperature sensitivity.	Carbachol	131-140	latexin	Homo sapiens	127-130
44657-1	1979	The perfused stomach in the anaesthetized rat was used to investigate the action of somatostatin on the gastric acid secretion stimulated by gastrin, histamine and carbamylcholine.	Carbachol	164-179	somatostatin	Rattus norvegicus	84-96
41059-9	1979	Betsamide antagonized the contractile effects of carbachol and 5-hydroxytryptamine on the rat vas deferens, but not the beta-responses of the guinea-pig trachea to adrenaline and isoproenaline.	Carbachol	49-58	arginine vasopressin	Rattus norvegicus	94-97
464093-9	1979	Carbachol may increase Ca2+ influx as well as utilize sequestered Ca2+.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	23-26
6153798-1	1980	Substance P inhibits carbamylcholine-induced 22Na+ uptake in the clonal cell line PC12.	Carbachol	21-36	tachykinin precursor 1	Homo sapiens	0-11
37961-1	1979	1 Isolated lung parenchymal strips of the dog contracted in response to histamine &gt; carbachol &gt; prostaglandin F(2alpha) (PGF(2alpha)) &gt; bradykinin (Bk) &gt; 5-hydroxytryptamine (5-HT).	Carbachol	87-96	kininogen 1	Canis lupus familiaris	145-155
37961-1	1979	1 Isolated lung parenchymal strips of the dog contracted in response to histamine &gt; carbachol &gt; prostaglandin F(2alpha) (PGF(2alpha)) &gt; bradykinin (Bk) &gt; 5-hydroxytryptamine (5-HT).	Carbachol	87-96	kininogen 1	Canis lupus familiaris	157-159
464093-9	1979	Carbachol may increase Ca2+ influx as well as utilize sequestered Ca2+.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	66-69
217365-4	1978	The assay was used to study the time course of the cyclic GMP changes that occur after stimulation of neuroblastoma cells with carbamoylcholine and the dependence of the cyclic GMP changes on the carbamoylcholine concentration.	Carbachol	127-143	5'-nucleotidase, cytosolic II	Mus musculus	58-61
446418-3	1979	In stress-adapted normal mice, injection of carbamyl choline (CCh) reduced the BRI levels.	Carbachol	44-60	integral membrane protein 2B	Mus musculus	79-82
446418-3	1979	In stress-adapted normal mice, injection of carbamyl choline (CCh) reduced the BRI levels.	Carbachol	62-65	integral membrane protein 2B	Mus musculus	79-82
225471-10	1979	It is suggested that superficial AII-excited neurones have a cholinergic excitatory synapse with the deeper carbachol-excited neurones.	Carbachol	108-117	angiotensinogen	Rattus norvegicus	33-36
225471-18	1979	It is suggested that AII units driven antidromically are actually carbachol-sensitive neurones driven by the more superficial AII-sensitive cells.	Carbachol	66-75	angiotensinogen	Rattus norvegicus	21-24
469778-7	1979	20 microgram Carbachol elicited a highly significant rise in plasma growth hormone, suggesting a cholinergic component in the neural control of growth hormone in sheep.	Carbachol	13-22	somatotropin	Ovis aries	68-82
469778-7	1979	20 microgram Carbachol elicited a highly significant rise in plasma growth hormone, suggesting a cholinergic component in the neural control of growth hormone in sheep.	Carbachol	13-22	somatotropin	Ovis aries	144-158
222025-3	1979	Exogenous cyclic 3",5"-AMP (cAMP) and substances known to increase the intracellular concentration of this nucleotide (isoproterenol, theophylline, noradrenaline, lactate) were shown to inhibit the transport of fluorescein (a weak organic acid) into the rat renal proximal tubules at 20 degrees C. Carbacholine decreasing intracellular cAMP concentration stimulated the transport.	Carbachol	298-310	cathelicidin antimicrobial peptide	Rattus norvegicus	10-26
216273-6	1978	Carbachol increased modestly, but significantly, the levels of cyclic GMP in isolated toad bladder epithelial cells.	Carbachol	0-9	5'-nucleotidase, cytosolic II	Homo sapiens	70-73
31192-7	1978	N-Methylhydroxylamine also blocked the increases of cyclic GMP levels by carbachol, prostaglandin E1 and N-methyl-N"-nitro-N-nitrosoguanidine in neuroblastoma N1E 115 cells.	Carbachol	73-82	5'-nucleotidase, cytosolic II	Mus musculus	59-62
217365-4	1978	The assay was used to study the time course of the cyclic GMP changes that occur after stimulation of neuroblastoma cells with carbamoylcholine and the dependence of the cyclic GMP changes on the carbamoylcholine concentration.	Carbachol	196-212	5'-nucleotidase, cytosolic II	Mus musculus	177-180
401096-8	1978	VIP induced a dose-dependent relaxation upon contraction by carbamylcholine.	Carbachol	60-75	vasoactive intestinal peptide	Sus scrofa	0-3
210883-5	1978	Finally, position 8 aliphatic substituted analogues of AII were competitive antagonists of AII-induced drinking, and also inhibited drinking induced by renin, SRS and AI injected through the same intracranial cannula, but they did not inhibit carbachol-induced drinking.	Carbachol	243-252	angiotensinogen	Rattus norvegicus	55-58
216539-2	1978	Carbamylcholine inhibited somewhat the vasopressin depletion in the neurohypophysis, but not earlier than under severe dehydration (8th and 12th day).	Carbachol	0-15	arginine vasopressin	Rattus norvegicus	39-50
738215-0	1978	Vasopressin release from incubated in situ posterior pituitary lobe after intraventricular injection of carbachol or atropine.	Carbachol	104-113	arginine vasopressin	Rattus norvegicus	0-11
738215-3	1978	The increase in the release of vasopressin following intracarotid infusions of hypertonic solution augmented by intraventricular injection of carbachol was found.	Carbachol	142-151	arginine vasopressin	Rattus norvegicus	31-42
738215-5	1978	The effects of carbachol and atropine indicate that mediation at synapses in the nucleus supraopticus involved in the release of vasopressin induced by osmotic stimulation is cholinergic.	Carbachol	15-24	arginine vasopressin	Rattus norvegicus	129-140
202611-8	1978	This defect in beige mice could be corrected by chronic administration of carbamyl choline (t((1/2)) = 3.5 h), a cholinergic agonist which raises intracellular cyclic GMP levels.	Carbachol	74-90	5'-nucleotidase, cytosolic II	Mus musculus	167-170
198531-8	1977	The responses to CCK-OP or carbamylcholine were potentiated by secretin, VIP or dibutyryl cyclic AMP.	Carbachol	27-42	vasoactive intestinal peptide	Homo sapiens	73-76
198531-10	1977	The responses to secretin or VIP were potentiated by CCK-OP, carbamylcholine, or dibutyryl cyclic GMP.	Carbachol	61-76	vasoactive intestinal peptide	Homo sapiens	29-32
19825-7	1977	Cyclic GMP levels were increased by carbachol, acetylcholine, and the phosphodiesterase inhibitor, aminophylline, but not by DSCG, or beta-adrenergic agonists.	Carbachol	36-45	5'-nucleotidase, cytosolic II	Mus musculus	7-10
838187-3	1977	Somatostatin inhibited gastric secretion after all three stimuli, with decreasing potency against carbachol, pentagastrin and histamine.	Carbachol	98-107	somatostatin	Canis lupus familiaris	0-12
868526-0	1977	Content of vasopressin in the neurohypophysis of long-term dehydrated rats as influenced by carbachol treatment.	Carbachol	92-101	arginine vasopressin	Rattus norvegicus	11-22
6773423-2	1980	Carbachol caused a small increase in base-line water flow and inhibited, partially, vasopressin- (AVP) or cyclic AMP-stimulated water flow.	Carbachol	0-9	arginine vasopressin	Homo sapiens	84-95
929114-0	1977	The influence of graded distension and carbachol on the motor response to cholecystokinin in isolated guinea-pig antrum and fundus.	Carbachol	39-48	cholecystokinin	Cavia porcellus	74-89
929114-3	1977	The responses to cholecystokinin were additive with low doses (10(-7)M) of carbachol, but diminished or abolished by prestimulation with higher doses.	Carbachol	75-84	cholecystokinin	Cavia porcellus	17-32
868526-1	1977	Content of vasopressin in the neurohypophysis of long-term dehydrated rats as influenced by carbachol treatment.	Carbachol	92-101	arginine vasopressin	Rattus norvegicus	11-22
868526-5	1977	Under extreme dehydration (8 and 12 days) the vasopressin depletion in the neurohypophysis was significantly inhibited in the carbachol-treated animals.	Carbachol	126-135	arginine vasopressin	Rattus norvegicus	46-57
181380-4	1976	With CCK-OP an effect on both functions could be detected at 10(-10) M and maximal stimulation occurred at 3 X 10(-8) M. With carbamylcholine an effect on both functions could be detected at 10(-5) M and maximal stimulation occurred at 3 X 10(-3) M. Atropine inhibited stimulation of both cyclic GMP and calcium outflux by carbamylcholine but not by CCK-OP.	Carbachol	126-141	cholecystokinin	Cavia porcellus	5-8
197234-7	1977	Carbachol (100 micrometer) caused a twofold increase in cyclic GMP without affecting cyclic AMP levels.	Carbachol	0-9	5'-nucleotidase, cytosolic II	Homo sapiens	63-66
949726-8	1976	Stimulation of the submandibular gland with carbachol (2 mg/kg) led to a massive release of the content of the secretory granules, including NGF, into the salivary duct.	Carbachol	44-53	nerve growth factor	Mus musculus	141-144
962435-1	1976	Desensitization of the isolated rat vas deferens was demonstrated by using noradrenaline, 5-hydroxytryptamine, carbachol, acetylcholine or barium chloride as a test concentration after a large concentration (concentration producing a contraction that was 80% of the maximum) of the same agonist.	Carbachol	111-120	arginine vasopressin	Rattus norvegicus	36-39
181380-4	1976	With CCK-OP an effect on both functions could be detected at 10(-10) M and maximal stimulation occurred at 3 X 10(-8) M. With carbamylcholine an effect on both functions could be detected at 10(-5) M and maximal stimulation occurred at 3 X 10(-3) M. Atropine inhibited stimulation of both cyclic GMP and calcium outflux by carbamylcholine but not by CCK-OP.	Carbachol	126-141	cholecystokinin	Cavia porcellus	350-353
6897-0	1976	Induction of tyrosine 3-monooxygenase elicited by carbamylcholine in intact and denervated adrenal medulla: role of protein kinase activation and translocation.	Carbachol	50-65	tyrosine hydroxylase	Homo sapiens	13-37
1278094-5	1976	The cholinergic agonists arecoline, nicotine, and carbachol significantly inhibited the afternoon surge of prolactin.	Carbachol	50-59	prolactin	Rattus norvegicus	107-116
4115-8	1976	Conversely, carbamylcholine rapidly increased lymphocyte cyclic GMP but was not mitogenic.	Carbachol	12-27	5'-nucleotidase, cytosolic II	Mus musculus	64-67
1066992-8	1976	Rat diaphragms and eel electroplax incubated with antisera to Torpedo and eel AChR showed a 50%-60% reduction in carbamylcholine depolarization.	Carbachol	113-128	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	78-82
1262469-13	1976	Animals treated for 3 wk and longer with carbamylcholine or carbamyl beta-methylcholline show normal granule morphology and a normal degree of concanavalin A cap formation in peripheral blood PMN leukocytes.	Carbachol	41-56	tubulin-specific chaperone E	Mus musculus	192-195
813769-9	1976	The carbachol effect is much less dependent on calcium, as it occurs even in a Ca2+ -free medium containing 10(-4) M ethyleneglycol-bis(beta-aminoethylether)-N,N-tetraacetic acid.	Carbachol	4-13	carbonic anhydrase 2	Oryctolagus cuniculus	79-82
813769-11	1976	Carbachol causes a marked increase in the 45Ca2+ efflux from pre-loaded pancreas fragments in both a normal Krebs-Ringer bicarbonate medium and this Ca2+ -free medium.	Carbachol	0-9	carbonic anhydrase 2	Oryctolagus cuniculus	44-47
813769-16	1976	It is concluded that both substances stimulate pancreatic enzyme secretion by increasing the cytoplasmic calcium concentration, through an increase in the calcium permeability of the plasma membrane in the case of the ionophore, and through a release of Ca2+ from intracellular stores in the case of carbachol.	Carbachol	300-309	carbonic anhydrase 2	Oryctolagus cuniculus	254-257
173397-10	1976	The Ca2+ antagonist D600 blocks the stimulatory effects of both carbamylcholine and pancreozymin only partially.	Carbachol	64-79	carbonic anhydrase 2	Rattus norvegicus	4-7
7752-7	1976	A 4 h pulse of 10(-4) M carbamylcholine produced optimal induction of DBH and TH 24 h and 48 h later respectively.	Carbachol	24-39	tyrosine hydroxylase	Rattus norvegicus	78-80
7752-5	1976	Carbamylcholine, acetylcholine and nicotine at concentrations of 10(-4) M elicited a selective induction of TH and DBH both in intact and decentralized ganglia via nicotinic receptor stimulation.	Carbachol	0-15	tyrosine hydroxylase	Rattus norvegicus	108-110
2926-4	1976	Hypertonic saline and carbachol suppressed renin release.	Carbachol	22-31	renin	Rattus norvegicus	43-48
7752-5	1976	Carbamylcholine, acetylcholine and nicotine at concentrations of 10(-4) M elicited a selective induction of TH and DBH both in intact and decentralized ganglia via nicotinic receptor stimulation.	Carbachol	0-15	dopamine beta-hydroxylase	Rattus norvegicus	115-118
7752-7	1976	A 4 h pulse of 10(-4) M carbamylcholine produced optimal induction of DBH and TH 24 h and 48 h later respectively.	Carbachol	24-39	dopamine beta-hydroxylase	Rattus norvegicus	70-73
7752-8	1976	Longer exposure to carbamylcholine resulted in a significantly smaller rise in TH activity.	Carbachol	19-34	tyrosine hydroxylase	Rattus norvegicus	79-81
1193326-2	1975	CCH induced a sharp decrease in D50 (dose of secretin which elicits half the calculated maximal response) but no increase in maximal response to secretin.	Carbachol	0-3	SCT	Canis lupus familiaris	45-53
1265437-5	1976	It is concluded, that the carbachol-induced rise in the basal sphincter pressure is not dependent on an increase in serum gastrin, but probably attributable to either direct cholinergic stimulation of the receptors or a cholinergically enhanced sensitivity of the receptors for gastrin.	Carbachol	26-35	gastrin	Homo sapiens	278-285
1167546-6	1975	The carbamylcholine-induced Na+ transport activity of the receptor is inhibited 50% by 4 muM D-tubocurarine, 100 muM atropine, or 1.6 nM diiodo-alpha-bungarotoxin but is not affected by tetrodotoxin.	Carbachol	4-19	latexin	Homo sapiens	89-92
1167546-6	1975	The carbamylcholine-induced Na+ transport activity of the receptor is inhibited 50% by 4 muM D-tubocurarine, 100 muM atropine, or 1.6 nM diiodo-alpha-bungarotoxin but is not affected by tetrodotoxin.	Carbachol	4-19	latexin	Homo sapiens	113-116
1193326-3	1975	Experiments performed under different haemodynamic conditions show that this potentiating effect (synergism) is partly due to vasomotor modifications and chiefly to the action of CCH on the receptor of secretin.	Carbachol	179-182	SCT	Canis lupus familiaris	202-210
235784-4	1975	The results indicate an effect of carbachol on acid, pepsin, and IF secretion, independent of changes in plasma gastrin concentration.	Carbachol	34-43	cobalamin binding intrinsic factor	Homo sapiens	65-67
4365701-1	1973	Low concentrations of insulin (120 muunits/ml) and of carbamylcholine (1 muM) increase cyclic GMP content in isolated fat cells by 350%.	Carbachol	54-69	5'-nucleotidase, cytosolic II	Homo sapiens	94-97
235784-2	1975	The volume of gastric secretion and the concentration and output of acid, pepsin, and IF increased significantly during infusion of carbachol alone, whereas the plasma gastrin concentration remained unchanged.	Carbachol	132-141	cobalamin binding intrinsic factor	Homo sapiens	86-88
4437728-0	1974	Reduced behavioural effects of intrahippocampally administered carbachol in rats with low cholinesterase activity.	Carbachol	63-72	butyrylcholinesterase	Rattus norvegicus	90-104
4357615-7	1974	Incubation of cells with exogenous cAMP or with agents that increase endogenous cAMP levels (prostaglandin E1, histamine, isoproterenol, and cholera enterotoxin) reduced extrusion of lysosomal enzymes; in contrast, exogenous cGMP and carbamylcholine chloride (which increases endogenous cGMP levels), increased beta-glucuronidase release.	Carbachol	234-258	cathelicidin antimicrobial peptide	Homo sapiens	35-39
4357615-7	1974	Incubation of cells with exogenous cAMP or with agents that increase endogenous cAMP levels (prostaglandin E1, histamine, isoproterenol, and cholera enterotoxin) reduced extrusion of lysosomal enzymes; in contrast, exogenous cGMP and carbamylcholine chloride (which increases endogenous cGMP levels), increased beta-glucuronidase release.	Carbachol	234-258	cathelicidin antimicrobial peptide	Homo sapiens	80-84
4365701-2	1973	The maximal amount of cyclic GMP, achieved within 2 min after addition of insulin or carbamylcholine, falls rapidly for insulin and much more slowly for carbamylcholine.	Carbachol	85-100	5'-nucleotidase, cytosolic II	Homo sapiens	29-32
4365701-2	1973	The maximal amount of cyclic GMP, achieved within 2 min after addition of insulin or carbamylcholine, falls rapidly for insulin and much more slowly for carbamylcholine.	Carbachol	85-100	insulin	Homo sapiens	120-127
4365701-2	1973	The maximal amount of cyclic GMP, achieved within 2 min after addition of insulin or carbamylcholine, falls rapidly for insulin and much more slowly for carbamylcholine.	Carbachol	153-168	5'-nucleotidase, cytosolic II	Homo sapiens	29-32
4365701-2	1973	The maximal amount of cyclic GMP, achieved within 2 min after addition of insulin or carbamylcholine, falls rapidly for insulin and much more slowly for carbamylcholine.	Carbachol	153-168	insulin	Homo sapiens	74-81
4365701-5	1973	Insulin and carbamylcholine increase the concentration of cyclic GMP in rat-liver slices by 400%; the effects of both agents occur rapidly and are relatively transient.	Carbachol	12-27	5'-nucleotidase, cytosolic II	Homo sapiens	65-68
4365701-7	1973	Carbamylcholine, however, causes a substantial increase in the cyclic GMP content of these lymphocytes.	Carbachol	0-15	5'-nucleotidase, cytosolic II	Homo sapiens	70-73
4764536-0	1973	The relationship between inhibition of acetylcholinesterase and sensitivity of the rat ileum to carbachol.	Carbachol	96-105	acetylcholinesterase	Rattus norvegicus	39-59
5569117-0	1971	Effect of carbachol on phosphoenolpyruvate carboxykinase and glucokinase in rat liver.	Carbachol	10-19	glucokinase	Rattus norvegicus	61-72
24173288-2	1971	The effect of carbamylcholine (Carb) on the release of(22)Na(+) by excitable microsacs is reversible: Carb does not promote an irreversible lysis of the microsacs.	Carbachol	14-29	syntaxin 8	Homo sapiens	31-35
4764290-0	1973	Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor.	Carbachol	54-63	butyrylcholinesterase	Rattus norvegicus	127-141
5104566-0	1971	Release of oxytocin and vasopressin in lactating rats after injection of carbachol into the third ventricle.	Carbachol	73-82	arginine vasopressin	Rattus norvegicus	24-35
5272331-1	1970	p-Nitrobenzene diazonium fluoroborate (NDF) is a potent inhibitor of the carbamylcholine-induced depolarization of the electroplax and of acetylcholinesterase.	Carbachol	73-88	neuregulin 1	Homo sapiens	39-42
5272331-1	1970	p-Nitrobenzene diazonium fluoroborate (NDF) is a potent inhibitor of the carbamylcholine-induced depolarization of the electroplax and of acetylcholinesterase.	Carbachol	73-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	138-158
5767890-4	1969	In addition, these units are excited by intracarotid injections of carbachol, acetylcholine and NaCl (5%) which are less effective stimuli for vasopressin release.3.	Carbachol	67-76	arginine vasopressin	Rattus norvegicus	143-154
13824696-0	1960	Inhibition of cholinesterase with methylfluorophosphorylcholine and carbocholine: spontaneous return of activity.	Carbachol	68-80	butyrylcholinesterase	Homo sapiens	14-28
33915166-9	2021	In agreement with reduced CCKBC number in TLE, electrical recordings revealed a significant reduction in amplitude and frequency of IPSCs in CA1 PCs evoked by carbachol (commonly used to excite CCK+ interneurons) in ventral CA1 regions from epileptic mice versus sham controls.	Carbachol	159-168	carbonic anhydrase 1	Mus musculus	141-144
33795544-6	2021	In carbachol-contracted gastric and ileal strips, contractile changes were recorded by adding NES- 1 (0.3 nmol/L), GLP-1, CCK-1, and gastrin/CCK-2 antagonists.	Carbachol	3-12	gastrin	Rattus norvegicus	133-140
4556090-0	1972	Influence of acetyl- -methylcholine, carbamoylcholine, and bis-pyridinium compounds on the activity of acetylcholinesterase.	Carbachol	37-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123
4625268-13	1972	The time-course of post-carbachol hyperpolarization accorded with a Na(+) extrusion process whose rate was directly proportional to [Na(+)](i) with a rate constant of 0.38+/-0.02 min(-1) at 23-27 degrees C.9.	Carbachol	24-33	complement C9	Rattus norvegicus	204-207
33915166-9	2021	In agreement with reduced CCKBC number in TLE, electrical recordings revealed a significant reduction in amplitude and frequency of IPSCs in CA1 PCs evoked by carbachol (commonly used to excite CCK+ interneurons) in ventral CA1 regions from epileptic mice versus sham controls.	Carbachol	159-168	carbonic anhydrase 1	Mus musculus	224-227
33897375-5	2021	Application of the cholinomimetic drug carbachol leads to a decrease in DAT activity in primary cultures while the M1/M5-specific antagonist, pirenzepine, blocks these effects.	Carbachol	39-48	solute carrier family 6 member 3	Homo sapiens	72-75
33865856-4	2021	We report here that monomeric wild type (WT) mouse SK1 (GFP-mSK1) translocates to the PM of MCF-7L cells stimulated with carbachol or phorbol myristate acetate (PMA), whereas the dimer translocates to the PM in response to sphingosine 1-phosphate (S1P); thus, the equilibrium between monomer and dimer is sensitive to cellular stimulus.	Carbachol	121-130	sphingosine kinase 1	Mus musculus	51-54
33865856-4	2021	We report here that monomeric wild type (WT) mouse SK1 (GFP-mSK1) translocates to the PM of MCF-7L cells stimulated with carbachol or phorbol myristate acetate (PMA), whereas the dimer translocates to the PM in response to sphingosine 1-phosphate (S1P); thus, the equilibrium between monomer and dimer is sensitive to cellular stimulus.	Carbachol	121-130	skin antigen 1	Mus musculus	60-64
33865856-5	2021	In addition, carbachol and PMA induced translocation of monomeric GFP-mSK1 to lamellipodia, while S1P induced translocation of dimeric GFP-mSK1 to filopodia, suggesting that SK1 regulates different cell biological processes dependent on dimerization.	Carbachol	13-22	skin antigen 1	Mus musculus	70-74
33865856-5	2021	In addition, carbachol and PMA induced translocation of monomeric GFP-mSK1 to lamellipodia, while S1P induced translocation of dimeric GFP-mSK1 to filopodia, suggesting that SK1 regulates different cell biological processes dependent on dimerization.	Carbachol	13-22	sphingosine kinase 1	Homo sapiens	71-74
33897375-6	2021	The M3 antagonist, DAU 5884, does not affect, but a positive modulator of M5, VU 0238429, enhances the loss of DAT function in response to carbachol and acetylcholine.	Carbachol	139-148	solute carrier family 6 member 3	Homo sapiens	111-114
33897375-8	2021	Bisindolylmaleimide, a PKC inhibitor, blocks the effects of carbachol stimulation on dopamine uptake, supporting a role for PKC in muscarinic receptor-mediated DAT internalization.	Carbachol	60-69	solute carrier family 6 member 3	Homo sapiens	160-163
33897375-10	2021	A Gq-specific inhibitor peptide also blocks the effects of carbachol on DAT in primary cultures, confirming Gq as the G-protein that couples M1/M5 receptors to PKC activation in these cells.	Carbachol	59-68	solute carrier family 6 member 3	Homo sapiens	72-75
33561807-7	2021	RESULTS: Intraperitoneal injection, but not localized intraglandular administration, of AR-C118925 significantly enhanced carbachol-induced salivation and reduced lymphocytic foci and immune cell markers in SMGs of 5 month old NOD.H-2h4 DKO mice, compared to vehicle-injected control mice.	Carbachol	122-131	ferredoxin reductase	Mus musculus	88-90
33837176-6	2021	Performing extracellular recordings in brain slices from p75NTR knockout mice (p75-/-) in presence of the muscarinic agonist carbachol, we find that gamma oscillation power and rhythmicity are increased compared to wild-type (WT) mice.	Carbachol	125-134	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	57-63
33562815-5	2021	Live-cell imaging of cultured lacrimal gland acinar cells (LGAC) transduced with adenovirus encoding wild-type (WT) mCFP-Rab27a revealed carbachol-stimulated fusion and depletion of mCFP-Rab27a-enriched vesicles.	Carbachol	137-146	complement factor properdin	Mus musculus	116-120
33739386-2	2021	We discovered that the application of a cholinergic agonist, carbachol (Cch), which triggers oscillatory activity in the gamma range, induces the activity of matrix metalloproteinase 9 (MMP-9)-an enzyme necessary for the maintenance of synaptic plasticity.	Carbachol	61-70	matrix metallopeptidase 9	Homo sapiens	158-184
33739386-2	2021	We discovered that the application of a cholinergic agonist, carbachol (Cch), which triggers oscillatory activity in the gamma range, induces the activity of matrix metalloproteinase 9 (MMP-9)-an enzyme necessary for the maintenance of synaptic plasticity.	Carbachol	61-70	matrix metallopeptidase 9	Homo sapiens	186-191
33739386-2	2021	We discovered that the application of a cholinergic agonist, carbachol (Cch), which triggers oscillatory activity in the gamma range, induces the activity of matrix metalloproteinase 9 (MMP-9)-an enzyme necessary for the maintenance of synaptic plasticity.	Carbachol	72-75	matrix metallopeptidase 9	Homo sapiens	158-184
33739386-2	2021	We discovered that the application of a cholinergic agonist, carbachol (Cch), which triggers oscillatory activity in the gamma range, induces the activity of matrix metalloproteinase 9 (MMP-9)-an enzyme necessary for the maintenance of synaptic plasticity.	Carbachol	72-75	matrix metallopeptidase 9	Homo sapiens	186-191
33739386-3	2021	Using electrophysiological recordings in hippocampal organotypic slices, we show that Cch potentiates the frequency of miniature inhibitory and excitatory postsynaptic currents (mIPSCs and mEPSCs, respectively) in CA1 neurons and this effect is MMP-9 dependent.	Carbachol	86-89	carbonic anhydrase 1	Homo sapiens	214-217
33739386-3	2021	Using electrophysiological recordings in hippocampal organotypic slices, we show that Cch potentiates the frequency of miniature inhibitory and excitatory postsynaptic currents (mIPSCs and mEPSCs, respectively) in CA1 neurons and this effect is MMP-9 dependent.	Carbachol	86-89	matrix metallopeptidase 9	Homo sapiens	245-250
33562815-5	2021	Live-cell imaging of cultured lacrimal gland acinar cells (LGAC) transduced with adenovirus encoding wild-type (WT) mCFP-Rab27a revealed carbachol-stimulated fusion and depletion of mCFP-Rab27a-enriched vesicles.	Carbachol	137-146	RAB27A, member RAS oncogene family	Mus musculus	121-127
33562815-5	2021	Live-cell imaging of cultured lacrimal gland acinar cells (LGAC) transduced with adenovirus encoding wild-type (WT) mCFP-Rab27a revealed carbachol-stimulated fusion and depletion of mCFP-Rab27a-enriched vesicles.	Carbachol	137-146	RAB27A, member RAS oncogene family	Mus musculus	187-193
33528684-6	2021	However, 7,8-DHF enhanced CCh-stimulated PLCgamma1 activation and strip contraction.	Carbachol	26-29	phospholipase C, gamma 1	Rattus norvegicus	41-50
33528684-11	2021	ANA-12, a specific TrkB antagonist, not only inhibited TrkB activation by 7,8-DHF but also suppressed 7,8-DHF-enhanced cholinergic contraction, 7,8-DHF/CCh-mediated activation of PLCgamma1/Akt, and M3 overexpression in colonic strips.	Carbachol	152-155	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	19-23
33562815-6	2021	LGAC transduced with dominant-negative (DN) mCFP-Rab27a exhibited significantly reduced carbachol-stimulated CTSS secretion by 0.5-fold and beta-hexosaminidase by 0.3-fold, relative to stimulated LGAC transduced with WT mCFP-Rab27a.	Carbachol	88-97	complement factor properdin	Mus musculus	44-48
33562815-6	2021	LGAC transduced with dominant-negative (DN) mCFP-Rab27a exhibited significantly reduced carbachol-stimulated CTSS secretion by 0.5-fold and beta-hexosaminidase by 0.3-fold, relative to stimulated LGAC transduced with WT mCFP-Rab27a.	Carbachol	88-97	RAB27A, member RAS oncogene family	Mus musculus	49-55
33562815-6	2021	LGAC transduced with dominant-negative (DN) mCFP-Rab27a exhibited significantly reduced carbachol-stimulated CTSS secretion by 0.5-fold and beta-hexosaminidase by 0.3-fold, relative to stimulated LGAC transduced with WT mCFP-Rab27a.	Carbachol	88-97	cathepsin S	Mus musculus	109-113
33562815-6	2021	LGAC transduced with dominant-negative (DN) mCFP-Rab27a exhibited significantly reduced carbachol-stimulated CTSS secretion by 0.5-fold and beta-hexosaminidase by 0.3-fold, relative to stimulated LGAC transduced with WT mCFP-Rab27a.	Carbachol	88-97	complement factor properdin	Mus musculus	220-224
33562815-6	2021	LGAC transduced with dominant-negative (DN) mCFP-Rab27a exhibited significantly reduced carbachol-stimulated CTSS secretion by 0.5-fold and beta-hexosaminidase by 0.3-fold, relative to stimulated LGAC transduced with WT mCFP-Rab27a.	Carbachol	88-97	RAB27A, member RAS oncogene family	Mus musculus	225-231
33528684-7	2021	The PLCgamma1 antagonist U73122 suppressed both CCh-stimulated and 7,8-DHF-enhanced/CCh-stimulated contraction.	Carbachol	48-51	phospholipase C, gamma 1	Rattus norvegicus	4-13
33528684-7	2021	The PLCgamma1 antagonist U73122 suppressed both CCh-stimulated and 7,8-DHF-enhanced/CCh-stimulated contraction.	Carbachol	84-87	phospholipase C, gamma 1	Rattus norvegicus	4-13
33528684-10	2021	Since 7,8-DHF increased Akt phosphorylation, and LY294002 (an antagonist of PI3K upstream of Akt) dramatically inhibited both 7,8-DHF-augmented M3 expression and 7,8-DHF-enhanced/CCh-stimulated contractions, we assumed that 7,8-DHF/TrkB/Akt was associated with the modulation of M3 expression in the colonic strips.	Carbachol	179-182	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
33528684-10	2021	Since 7,8-DHF increased Akt phosphorylation, and LY294002 (an antagonist of PI3K upstream of Akt) dramatically inhibited both 7,8-DHF-augmented M3 expression and 7,8-DHF-enhanced/CCh-stimulated contractions, we assumed that 7,8-DHF/TrkB/Akt was associated with the modulation of M3 expression in the colonic strips.	Carbachol	179-182	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
33537462-4	2021	Here, we show that TMEM16A protein abundance correlates with Cl- secretion in different regions of native intestine activated by the Ca2+-elevating muscarinic agonist carbachol (CCH).	Carbachol	167-176	anoctamin 1	Homo sapiens	19-26
33537462-4	2021	Here, we show that TMEM16A protein abundance correlates with Cl- secretion in different regions of native intestine activated by the Ca2+-elevating muscarinic agonist carbachol (CCH).	Carbachol	178-181	anoctamin 1	Homo sapiens	19-26
33537462-5	2021	Basal, as well as both cAMP- and CCH-stimulated Isc, was largely reduced in Ano1 +- mouse intestine.	Carbachol	33-36	anoctamin 1, calcium activated chloride channel	Mus musculus	76-80
33537462-8	2021	Cellular depletion of NHERF1 in human colonic T84 cells caused a significant reduction of both cAMP- and CCH-stimulated Isc.	Carbachol	105-108	SLC9A3 regulator 1	Homo sapiens	22-28
31910704-4	2020	Cumulative concentration response curves were constructed to OT and then the strips were incubated with atosiban (OT antagonist) and a second concentration response curve to OT were constructed.Results: Carbachol, contracted all human strips for the functionality test whereas OT in any concentrations did not produce significant contraction on all human strips.	Carbachol	203-212	oxytocin/neurophysin I prepropeptide	Homo sapiens	61-63
33390980-5	2020	Ketamine (100 microM) strongly inhibited both carbachol- and GTPgammaS-induced mICAT.	Carbachol	46-55	catenin beta interacting protein 1	Mus musculus	79-84
33563876-3	2021	The Loxl1-/- rats showed increased looseness and redundancy of the skin, the decreased intercontraction interval and voided volume in cystometry, the lower leak-point pressure, thinner elastic fibers of the mesentery, bladder, urethra and vagina, and smaller contractile response of detrusor strips to carbachol when compared to the WT rats.	Carbachol	302-311	lysyl oxidase-like 1	Rattus norvegicus	4-9
31910704-4	2020	Cumulative concentration response curves were constructed to OT and then the strips were incubated with atosiban (OT antagonist) and a second concentration response curve to OT were constructed.Results: Carbachol, contracted all human strips for the functionality test whereas OT in any concentrations did not produce significant contraction on all human strips.	Carbachol	203-212	oxytocin/neurophysin I prepropeptide	Homo sapiens	114-116
31910704-4	2020	Cumulative concentration response curves were constructed to OT and then the strips were incubated with atosiban (OT antagonist) and a second concentration response curve to OT were constructed.Results: Carbachol, contracted all human strips for the functionality test whereas OT in any concentrations did not produce significant contraction on all human strips.	Carbachol	203-212	oxytocin/neurophysin I prepropeptide	Homo sapiens	114-116
31910704-4	2020	Cumulative concentration response curves were constructed to OT and then the strips were incubated with atosiban (OT antagonist) and a second concentration response curve to OT were constructed.Results: Carbachol, contracted all human strips for the functionality test whereas OT in any concentrations did not produce significant contraction on all human strips.	Carbachol	203-212	oxytocin/neurophysin I prepropeptide	Homo sapiens	114-116
32801121-6	2020	In our established human salivary gland-derived organoid culture system, we successfully induced an organoid swelling revealing the function of saliva secretion by the stimulation of carbachol, a non-selective cholinergic agonist, and forskolin, an activator of cystic fibrosis transmembrane conductance regulator (CFTR).	Carbachol	183-192	CF transmembrane conductance regulator	Homo sapiens	262-313
33172956-6	2021	In contrast, Gnb5-/- mice exhibited profound bradycardia on treatment with carbachol, while sympathetic modulation of the cardiac stimulation was not altered.	Carbachol	75-84	guanine nucleotide binding protein (G protein), beta 5	Mus musculus	13-17
32065420-7	2020	The gene and protein expression of collagen I (COL1), TIMP-1, and TIMP-2 was carbachol (CCH) concentration-dependently enhanced.	Carbachol	77-86	TIMP metallopeptidase inhibitor 1	Homo sapiens	54-60
32065420-7	2020	The gene and protein expression of collagen I (COL1), TIMP-1, and TIMP-2 was carbachol (CCH) concentration-dependently enhanced.	Carbachol	77-86	TIMP metallopeptidase inhibitor 2	Homo sapiens	66-72
32065420-7	2020	The gene and protein expression of collagen I (COL1), TIMP-1, and TIMP-2 was carbachol (CCH) concentration-dependently enhanced.	Carbachol	88-91	TIMP metallopeptidase inhibitor 1	Homo sapiens	54-60
32065420-7	2020	The gene and protein expression of collagen I (COL1), TIMP-1, and TIMP-2 was carbachol (CCH) concentration-dependently enhanced.	Carbachol	88-91	TIMP metallopeptidase inhibitor 2	Homo sapiens	66-72
32065420-9	2020	The CCH-induced protein expression of COL1, TIMP-1, and TIMP-2, however, was obviously reduced by the pretreatment of muscarinic receptor antagonists, atropine, and M3 -preferring antagonist (1,1-dimethyl-4-diphenyl-acetoxypiperidinium iodide [4-DAMP]).	Carbachol	4-7	TIMP metallopeptidase inhibitor 1	Homo sapiens	44-50
32065420-9	2020	The CCH-induced protein expression of COL1, TIMP-1, and TIMP-2, however, was obviously reduced by the pretreatment of muscarinic receptor antagonists, atropine, and M3 -preferring antagonist (1,1-dimethyl-4-diphenyl-acetoxypiperidinium iodide [4-DAMP]).	Carbachol	4-7	TIMP metallopeptidase inhibitor 2	Homo sapiens	56-62
32065420-10	2020	Furthermore, ERK1/2 was activated by 100 microM CCH when compared with the control group and the pretreatment of ERK1/2 inhibitor significantly suppressed the synthesis of COL1 induced by 100 microM CCH.	Carbachol	48-51	mitogen-activated protein kinase 3	Homo sapiens	13-19
32065420-10	2020	Furthermore, ERK1/2 was activated by 100 microM CCH when compared with the control group and the pretreatment of ERK1/2 inhibitor significantly suppressed the synthesis of COL1 induced by 100 microM CCH.	Carbachol	48-51	mitogen-activated protein kinase 3	Homo sapiens	113-119
32065420-10	2020	Furthermore, ERK1/2 was activated by 100 microM CCH when compared with the control group and the pretreatment of ERK1/2 inhibitor significantly suppressed the synthesis of COL1 induced by 100 microM CCH.	Carbachol	199-202	mitogen-activated protein kinase 3	Homo sapiens	13-19
32065420-10	2020	Furthermore, ERK1/2 was activated by 100 microM CCH when compared with the control group and the pretreatment of ERK1/2 inhibitor significantly suppressed the synthesis of COL1 induced by 100 microM CCH.	Carbachol	199-202	mitogen-activated protein kinase 3	Homo sapiens	113-119
32065420-11	2020	Besides, CCH-induced phosphorylation of ERK1/2 was remarkably restrained by the pretreatment of 4-DAMP.	Carbachol	9-12	mitogen-activated protein kinase 3	Homo sapiens	40-46
31975215-8	2020	Knockdown of ACOX3 in HASMC, using siRNA, significantly repressed HASMC contraction triggered by carbachol.	Carbachol	97-106	acyl-CoA oxidase 3, pristanoyl	Homo sapiens	13-18
31975215-9	2020	The carbachol-induced HASMC contraction was restored by transfection with plasmids encoding siRNA-resistant wild-type ACOX3, but not by transfection with ACOX3 G222E or by co-transfection with ACOX3 F79 V and ACOX3 G222E, indicating that the two ACOX3 mutants suppress carbachol-induced HASMC contraction.	Carbachol	4-13	acyl-CoA oxidase 3, pristanoyl	Homo sapiens	118-123
33041794-10	2020	UCL 1684 reduced carbachol-evoked ASM contractions (>90%, IC50 0.43 muM), and calcium mobilization in rodent and human lung ASM cells.	Carbachol	17-26	H19 imprinted maternally expressed transcript	Homo sapiens	34-37
32394805-5	2020	We show that in MCA of rats with SCI, there is 55% reduction in the maximal vasodilator response to carbachol, which is associated with reduced expression of endothelial marker cluster of differentiation 31 (CD31) and transient receptor potential cation channel 4 (TRPV4) channels.	Carbachol	100-109	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	265-270
32911509-5	2020	The addition of carbachol or arecaidine propargyl ester, a non-selective or a selective subtype 2 muscarinic receptor agonist respectively, plus paclitaxel reduces cell viability involving a down-regulation in the expression of ATP "binding cassette" G2 drug transporter and epidermal growth factor receptor.	Carbachol	16-25	epidermal growth factor receptor	Homo sapiens	275-307
32765779-0	2020	Carbachol protects the intestinal barrier in severe acute pancreatitis by regulating Cdc42/F-actin cytoskeleton.	Carbachol	0-9	cell division cycle 42	Rattus norvegicus	85-90
32765779-10	2020	In addition, the expression of Cdc42, F-actin and claudin-2 was significantly higher in the SAP and SAP + carbachol groups compared with the SO and SO + carbachol groups (P<0.05), and the expression of occludin and zonula occludens-1 were significantly higher in the SO and SO + carbachol groups compared with the SAP and SAP + carbachol groups (P<0.05).	Carbachol	106-115	cell division cycle 42	Rattus norvegicus	31-36
32765779-10	2020	In addition, the expression of Cdc42, F-actin and claudin-2 was significantly higher in the SAP and SAP + carbachol groups compared with the SO and SO + carbachol groups (P<0.05), and the expression of occludin and zonula occludens-1 were significantly higher in the SO and SO + carbachol groups compared with the SAP and SAP + carbachol groups (P<0.05).	Carbachol	106-115	claudin 2	Rattus norvegicus	50-59
32765779-10	2020	In addition, the expression of Cdc42, F-actin and claudin-2 was significantly higher in the SAP and SAP + carbachol groups compared with the SO and SO + carbachol groups (P<0.05), and the expression of occludin and zonula occludens-1 were significantly higher in the SO and SO + carbachol groups compared with the SAP and SAP + carbachol groups (P<0.05).	Carbachol	106-115	occludin	Rattus norvegicus	202-210
32765779-10	2020	In addition, the expression of Cdc42, F-actin and claudin-2 was significantly higher in the SAP and SAP + carbachol groups compared with the SO and SO + carbachol groups (P<0.05), and the expression of occludin and zonula occludens-1 were significantly higher in the SO and SO + carbachol groups compared with the SAP and SAP + carbachol groups (P<0.05).	Carbachol	153-162	cell division cycle 42	Rattus norvegicus	31-36
32765779-10	2020	In addition, the expression of Cdc42, F-actin and claudin-2 was significantly higher in the SAP and SAP + carbachol groups compared with the SO and SO + carbachol groups (P<0.05), and the expression of occludin and zonula occludens-1 were significantly higher in the SO and SO + carbachol groups compared with the SAP and SAP + carbachol groups (P<0.05).	Carbachol	153-162	cell division cycle 42	Rattus norvegicus	31-36
32765779-10	2020	In addition, the expression of Cdc42, F-actin and claudin-2 was significantly higher in the SAP and SAP + carbachol groups compared with the SO and SO + carbachol groups (P<0.05), and the expression of occludin and zonula occludens-1 were significantly higher in the SO and SO + carbachol groups compared with the SAP and SAP + carbachol groups (P<0.05).	Carbachol	153-162	cell division cycle 42	Rattus norvegicus	31-36
32765779-11	2020	In conclusion, these findings demonstrated that carbachol may protect the intestinal barrier in the SAP rat model without aggravating pancreatic injury via regulation of Cdc42/F-actin expression.	Carbachol	48-57	cell division cycle 42	Rattus norvegicus	170-175
32801121-6	2020	In our established human salivary gland-derived organoid culture system, we successfully induced an organoid swelling revealing the function of saliva secretion by the stimulation of carbachol, a non-selective cholinergic agonist, and forskolin, an activator of cystic fibrosis transmembrane conductance regulator (CFTR).	Carbachol	183-192	CF transmembrane conductance regulator	Homo sapiens	315-319
32606911-10	2020	Discussion: The findings suggest that chemical stimulation of the LH by carbachol possibly activates the orexin projecting neurons and subsequently, the VTA dopaminergic neurons involved in the orofacial pain modulation.	Carbachol	72-81	hypocretin neuropeptide precursor	Rattus norvegicus	105-111
32224266-11	2020	Furthermore, isolated atrial preparations and SAN myocytes from AngII infused mice had impaired responses to both ISO and CCh.	Carbachol	122-125	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	64-69
32652816-3	2020	EGFr TKIs (such as afatinib, erlotinib, and osimertinib) reversed the acute inhibitory effect of EGF on chloride secretion induced by carbachol (CCh) across T84 human colonic epithelial cells, which correlated with the diarrhea-inducing effect of each agent clinically.	Carbachol	134-143	epidermal growth factor receptor	Homo sapiens	0-4
32652816-3	2020	EGFr TKIs (such as afatinib, erlotinib, and osimertinib) reversed the acute inhibitory effect of EGF on chloride secretion induced by carbachol (CCh) across T84 human colonic epithelial cells, which correlated with the diarrhea-inducing effect of each agent clinically.	Carbachol	134-143	epidermal growth factor	Homo sapiens	0-3
32652816-3	2020	EGFr TKIs (such as afatinib, erlotinib, and osimertinib) reversed the acute inhibitory effect of EGF on chloride secretion induced by carbachol (CCh) across T84 human colonic epithelial cells, which correlated with the diarrhea-inducing effect of each agent clinically.	Carbachol	145-148	epidermal growth factor receptor	Homo sapiens	0-4
32652816-3	2020	EGFr TKIs (such as afatinib, erlotinib, and osimertinib) reversed the acute inhibitory effect of EGF on chloride secretion induced by carbachol (CCh) across T84 human colonic epithelial cells, which correlated with the diarrhea-inducing effect of each agent clinically.	Carbachol	145-148	epidermal growth factor	Homo sapiens	0-3
32268182-7	2020	It was also found that Hco-LGC-46 assembles with Hco-ACC-1 and produces a receptor that is over 5-fold more sensitive to ACh and responds to the cholinergic agonists methycholine and carbachol.	Carbachol	183-192	putative ligand-gated ion channel 46	Caenorhabditis elegans	27-33
32652816-5	2020	Furthermore, afatinib and erlotinib prevented EGF- or CCh-induced EGFr phosphorylation.	Carbachol	54-57	epidermal growth factor receptor	Homo sapiens	66-70
32652816-6	2020	EGFr TKIs also suppressed phosphorylation of extracellular signal-regulated kinase (Erk)1/2 in response to EGF, whereas they had weaker effects on CCh-induced Erk1/2 phosphorylation.	Carbachol	147-150	epidermal growth factor receptor	Homo sapiens	0-4
32652816-6	2020	EGFr TKIs also suppressed phosphorylation of extracellular signal-regulated kinase (Erk)1/2 in response to EGF, whereas they had weaker effects on CCh-induced Erk1/2 phosphorylation.	Carbachol	147-150	epidermal growth factor	Homo sapiens	0-3
32652816-6	2020	EGFr TKIs also suppressed phosphorylation of extracellular signal-regulated kinase (Erk)1/2 in response to EGF, whereas they had weaker effects on CCh-induced Erk1/2 phosphorylation.	Carbachol	147-150	mitogen-activated protein kinase 3	Homo sapiens	159-165
32652816-7	2020	In human EDMs, EGF potentiated ion transport induced by CCh, whereas afatinib reversed this effect.	Carbachol	56-59	epidermal growth factor	Homo sapiens	15-18
32652816-9	2020	CCh-activated Erk1/2 phosphorylation was relatively insensitive to EGFr TKIs and delayed the deleterious effects of EGFr TKIs on barrier function.	Carbachol	0-3	mitogen-activated protein kinase 3	Homo sapiens	14-20
32652816-9	2020	CCh-activated Erk1/2 phosphorylation was relatively insensitive to EGFr TKIs and delayed the deleterious effects of EGFr TKIs on barrier function.	Carbachol	0-3	epidermal growth factor receptor	Homo sapiens	116-120
32562388-11	2020	We observed a significantly smaller CCh response in Ts65Dn versus control euploid mice in the 6- to 10-min-interval postcarbachol injection.	Carbachol	36-39	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	52-58
32143816-5	2020	In carbachol pre-contracted strips, GLP-2 (20 nM) evoked a tetrodotoxin (TTX)-sensitive relaxation, similar in shape to the TTX-insensitive of 100 nM VIP.	Carbachol	3-12	glucagon-like peptide 2 receptor	Mus musculus	36-41
32495900-0	2020	Carbachol alleviates myocardial injury in septic rats through PI3K/AKT signaling pathway.	Carbachol	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	67-70
32495900-10	2020	CONCLUSIONS: Carbachol can reduce the release of inflammatory factors in myocardial cells, the expression of apoptotic proteins and the apoptosis of myocardial cells, and improve the cardiac function and survival rate of septic rats by inhibiting the PI3K/AKT signaling pathway.	Carbachol	13-22	AKT serine/threonine kinase 1	Rattus norvegicus	256-259
32268182-7	2020	It was also found that Hco-LGC-46 assembles with Hco-ACC-1 and produces a receptor that is over 5-fold more sensitive to ACh and responds to the cholinergic agonists methycholine and carbachol.	Carbachol	183-192	Acetylcholine-gated chloride channel subunit acc-1	Caenorhabditis elegans	53-58
31867686-8	2020	In male detrusor tissues, STK16-IN-1 inhibited contractions induced by the cholinergic agonists carbachol and metacholine, and contractions induced by U46619.	Carbachol	96-105	serine/threonine kinase 16	Homo sapiens	26-31
32350310-6	2020	Whereas SLC10A7 knockout HAP1 cells showed significantly increased calcium influx after thapsigargin, ionomycin and ATP/carbachol treatment, SLC10A7 overexpression reduced this calcium influx.	Carbachol	120-129	solute carrier family 10 member 7	Homo sapiens	8-15
32350310-6	2020	Whereas SLC10A7 knockout HAP1 cells showed significantly increased calcium influx after thapsigargin, ionomycin and ATP/carbachol treatment, SLC10A7 overexpression reduced this calcium influx.	Carbachol	120-129	huntingtin associated protein 1	Homo sapiens	25-29
31954803-3	2020	Preincubation of M2R-expressing HEK 293T cells with serum IgG fractions from chagasic patients with cardiovascular dysautonomia, followed by the addition of carbachol, resulted in the attenuation of agonist-induced Gi protein activation and arrestin-2 recruitment.	Carbachol	157-166	arrestin beta 1	Homo sapiens	241-251
32069351-8	2020	Furthermore, we examined how the intrinsic properties and action-potential firing were altered in CA2 pyramidal neurons treated with 10 microM carbachol.	Carbachol	143-152	carbonic anhydrase 2	Homo sapiens	98-101
32135149-8	2020	Results showed that intra-CA1 administration of SCH-23390 or sulpiride could prevent the intra-LH carbachol-induced antinociception.	Carbachol	98-107	carbonic anhydrase 1	Rattus norvegicus	26-29
32308799-3	2020	The antagonistic effect of these 1,4-DHP was tested by modulating the impact of carbachol-dependent mobilization of intracellular Ca2+ in SH-SY5Y cells.	Carbachol	80-89	dihydropyrimidinase	Homo sapiens	37-40
32089769-7	2020	In the presence of L-NAME, a nitric oxide synthase (NOS) inhibitor, the CCh curve remained unchanged in nonsensitized animals but had increased efficacy and potency in sensitized animals, indicating an inhibition of endothelial NOS but ineffective in inhibiting inducible NOS.	Carbachol	72-75	nitric oxide synthase, inducible	Cavia porcellus	29-50
32063920-15	2020	In addition, Mlx-8 also blocked the accumulation of total [3H]inositol phosphate induced by muscarinic agonist carbachol.	Carbachol	111-120	MAX dimerization protein MLX	Rattus norvegicus	13-16
31805312-4	2020	RESULTS: Treatment with IL-13 increased the potency of histamine, carbachol and leukotriene D4 as contractile agonists.	Carbachol	66-75	interleukin 13	Homo sapiens	24-29
31932898-4	2020	VIP-induced secretion is mediated by cAMP-activated protein kinase A (PKA), independently of increased [Ca2+]i. Synergistic secretion between VIP and the muscarinic agonist, carbachol, was demonstrated but only with submaximal carbachol.	Carbachol	174-183	vasoactive intestinal peptide	Rattus norvegicus	0-3
31932898-4	2020	VIP-induced secretion is mediated by cAMP-activated protein kinase A (PKA), independently of increased [Ca2+]i. Synergistic secretion between VIP and the muscarinic agonist, carbachol, was demonstrated but only with submaximal carbachol.	Carbachol	227-236	vasoactive intestinal peptide	Rattus norvegicus	0-3
31932898-4	2020	VIP-induced secretion is mediated by cAMP-activated protein kinase A (PKA), independently of increased [Ca2+]i. Synergistic secretion between VIP and the muscarinic agonist, carbachol, was demonstrated but only with submaximal carbachol.	Carbachol	227-236	vasoactive intestinal peptide	Rattus norvegicus	142-145
31932898-11	2020	Additional data suggest ryanodine receptors control VIP/PKA-mediated Ca2+ release from a Ca2+ pool also responsive to maximal carbachol.	Carbachol	126-135	vasoactive intestinal peptide	Rattus norvegicus	52-55
31909533-6	2020	Murine BSM strips overexpressing desmin or vimentin generated less force in response to KCl and carbachol relative to the levels in control murine BSM strips, an effect associated with increased JNK2 phosphorylation and reduced myosin light chain (MLC20 ) phosphorylation.	Carbachol	96-105	desmin	Mus musculus	33-39
31909533-6	2020	Murine BSM strips overexpressing desmin or vimentin generated less force in response to KCl and carbachol relative to the levels in control murine BSM strips, an effect associated with increased JNK2 phosphorylation and reduced myosin light chain (MLC20 ) phosphorylation.	Carbachol	96-105	vimentin	Mus musculus	43-51
31910706-14	2020	Erythroid differentiated K562 cells treated with CCh (100 muM).	Carbachol	49-52	latexin	Homo sapiens	58-61
31260679-8	2019	The results showed that OX1R and OX2R antagonists dose-dependently decreased the antinociceptive effect of carbachol.	Carbachol	107-116	hypocretin receptor 1	Rattus norvegicus	24-28
31767755-6	2019	Furthermore, DJ-1 ablation disturbed calcium efflux-induced IP3R3 degradation after carbachol treatment and caused IP3R3 accumulation at the MAM in vitro.	Carbachol	84-93	Parkinsonism associated deglycase	Homo sapiens	13-17
31767755-6	2019	Furthermore, DJ-1 ablation disturbed calcium efflux-induced IP3R3 degradation after carbachol treatment and caused IP3R3 accumulation at the MAM in vitro.	Carbachol	84-93	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	60-65
31493399-7	2019	We analyzed interactions between stromal interaction molecule 1 (STIM1) and SARAF in HEK cells stimulated with carbachol using fluorescence resonance energy transfer microscopy and immunoprecipitation.	Carbachol	111-120	stromal interaction molecule 1	Mus musculus	33-63
31493399-7	2019	We analyzed interactions between stromal interaction molecule 1 (STIM1) and SARAF in HEK cells stimulated with carbachol using fluorescence resonance energy transfer microscopy and immunoprecipitation.	Carbachol	111-120	stromal interaction molecule 1	Mus musculus	65-70
31493399-7	2019	We analyzed interactions between stromal interaction molecule 1 (STIM1) and SARAF in HEK cells stimulated with carbachol using fluorescence resonance energy transfer microscopy and immunoprecipitation.	Carbachol	111-120	store-operated calcium entry-associated regulatory factor	Mus musculus	76-81
31493399-13	2019	STIM1 interacted stably with SARAF following stimulation of HEK or mouse acinar cells with physiologic levels of carbachol, but only transiently following stimulation with pathologic levels of carbachol, leading to excessive Ca2+ influx.	Carbachol	113-122	stromal interaction molecule 1	Mus musculus	0-5
31493399-13	2019	STIM1 interacted stably with SARAF following stimulation of HEK or mouse acinar cells with physiologic levels of carbachol, but only transiently following stimulation with pathologic levels of carbachol, leading to excessive Ca2+ influx.	Carbachol	113-122	store-operated calcium entry-associated regulatory factor	Mus musculus	29-34
31493399-13	2019	STIM1 interacted stably with SARAF following stimulation of HEK or mouse acinar cells with physiologic levels of carbachol, but only transiently following stimulation with pathologic levels of carbachol, leading to excessive Ca2+ influx.	Carbachol	193-202	stromal interaction molecule 1	Mus musculus	0-5
31411061-7	2019	By contrast, carbachol-induced contraction of the ASM derived from Pkd2SM-CKO mice was significantly reduced compared with that in wild-type mice.	Carbachol	13-22	H19 imprinted maternally expressed transcript	Homo sapiens	50-53
31411061-7	2019	By contrast, carbachol-induced contraction of the ASM derived from Pkd2SM-CKO mice was significantly reduced compared with that in wild-type mice.	Carbachol	13-22	polycystin 2, transient receptor potential cation channel	Mus musculus	67-73
31411061-8	2019	In addition, relaxation of the carbachol-precontracted ASM by isoprenaline, a beta-adrenergic receptor agonist that acts through the cAMP/adenylyl cyclase pathway, was also significantly attenuated in Pkd2SM-CKO mice compared with that in wild-type mice.	Carbachol	31-40	H19 imprinted maternally expressed transcript	Homo sapiens	55-58
31411061-8	2019	In addition, relaxation of the carbachol-precontracted ASM by isoprenaline, a beta-adrenergic receptor agonist that acts through the cAMP/adenylyl cyclase pathway, was also significantly attenuated in Pkd2SM-CKO mice compared with that in wild-type mice.	Carbachol	31-40	polycystin 2, transient receptor potential cation channel	Mus musculus	201-207
31921474-5	2019	Sera from curdlan-injected SKG mice contained elevated titers of IgG (predominantly IgG1), autoantibody to the muscarinic type 3 receptor (M3R) and inhibited carbachol-induced Ca2+ signaling in salivary acinar cells.	Carbachol	158-167	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	65-68
31260679-8	2019	The results showed that OX1R and OX2R antagonists dose-dependently decreased the antinociceptive effect of carbachol.	Carbachol	107-116	hypocretin receptor 2	Rattus norvegicus	33-37
31260679-9	2019	In addition, the effective dose of SB334867 was lesser than that of TCS OX2 29, which indicates the more prominent role of OX1R of the DG in carbachol-induced antinociception.	Carbachol	141-150	hypocretin receptor 1	Rattus norvegicus	123-127
30697954-6	2019	The Rac1 inhibitor EHT1864 inhibited carbachol (CCh)-induced BSM contractions, although high K+ depolarization-induced BSM contractions were not significantly attenuated by EHT1864.	Carbachol	37-46	Rac family small GTPase 1	Mus musculus	4-8
31259654-5	2019	In rat tracheal rings, addition of both naringin and naringenin could concentration dependently relax carbachol (CCh)-evoked tonic contraction.	Carbachol	102-111	neurogenin 3	Rattus norvegicus	96-101
31259654-5	2019	In rat tracheal rings, addition of both naringin and naringenin could concentration dependently relax carbachol (CCh)-evoked tonic contraction.	Carbachol	113-116	neurogenin 3	Rattus norvegicus	96-101
31422097-9	2019	In addition, carbachol-induced contraction was reduced in isolated detrusor strips from the L-NAME group, and bladder expression of HIF-1 and connexin 43 showed upregulation.	Carbachol	13-22	gap junction protein, alpha 1	Rattus norvegicus	142-153
31243195-0	2019	Increased Rac1 Activation in the Enhanced Carbachol-Induced Bronchial Smooth Muscle Contraction of Repeatedly Antigen-Challenged Mice.	Carbachol	42-51	Rac family small GTPase 1	Mus musculus	10-14
31243195-4	2019	We here examined carbachol (CCh)-induced Rac1 activation in BSMs of Chal.	Carbachol	17-26	Rac family small GTPase 1	Mus musculus	41-45
31243195-4	2019	We here examined carbachol (CCh)-induced Rac1 activation in BSMs of Chal.	Carbachol	28-31	Rac family small GTPase 1	Mus musculus	41-45
31243195-8	2019	Furthermore, CCh-induced Rac1 activation was inhibited by pretreatment with Rac1-GEF inhibitor NSC23766 and Rac1 inhibitor EHT1864 in BSMs of sensitized-control (S.C.) and Chal.	Carbachol	13-16	Rac family small GTPase 1	Mus musculus	25-29
31243195-8	2019	Furthermore, CCh-induced Rac1 activation was inhibited by pretreatment with Rac1-GEF inhibitor NSC23766 and Rac1 inhibitor EHT1864 in BSMs of sensitized-control (S.C.) and Chal.	Carbachol	13-16	Rac family small GTPase 1	Mus musculus	76-80
31243195-8	2019	Furthermore, CCh-induced Rac1 activation was inhibited by pretreatment with Rac1-GEF inhibitor NSC23766 and Rac1 inhibitor EHT1864 in BSMs of sensitized-control (S.C.) and Chal.	Carbachol	13-16	rho/rac guanine nucleotide exchange factor (GEF) 2	Mus musculus	81-84
31243195-8	2019	Furthermore, CCh-induced Rac1 activation was inhibited by pretreatment with Rac1-GEF inhibitor NSC23766 and Rac1 inhibitor EHT1864 in BSMs of sensitized-control (S.C.) and Chal.	Carbachol	13-16	Rac family small GTPase 1	Mus musculus	76-80
31243195-10	2019	Compared with S.C. mice, CCh-induced Rac1 activation was increased in BSMs of Chal.	Carbachol	25-28	Rac family small GTPase 1	Mus musculus	37-41
31243195-12	2019	In conclusion, we reported that increased CCh-induced Rac1 activation via Tiam1 and Trio upregulation, in addition to upregulate Rac1, may be involved in increased CCh-induced BSM contractions in Chal.	Carbachol	42-45	Rac family small GTPase 1	Mus musculus	54-58
31243195-12	2019	In conclusion, we reported that increased CCh-induced Rac1 activation via Tiam1 and Trio upregulation, in addition to upregulate Rac1, may be involved in increased CCh-induced BSM contractions in Chal.	Carbachol	42-45	T cell lymphoma invasion and metastasis 1	Mus musculus	74-79
31243195-12	2019	In conclusion, we reported that increased CCh-induced Rac1 activation via Tiam1 and Trio upregulation, in addition to upregulate Rac1, may be involved in increased CCh-induced BSM contractions in Chal.	Carbachol	42-45	triple functional domain (PTPRF interacting)	Mus musculus	84-88
31243195-12	2019	In conclusion, we reported that increased CCh-induced Rac1 activation via Tiam1 and Trio upregulation, in addition to upregulate Rac1, may be involved in increased CCh-induced BSM contractions in Chal.	Carbachol	42-45	Rac family small GTPase 1	Mus musculus	129-133
31243195-12	2019	In conclusion, we reported that increased CCh-induced Rac1 activation via Tiam1 and Trio upregulation, in addition to upregulate Rac1, may be involved in increased CCh-induced BSM contractions in Chal.	Carbachol	164-167	Rac family small GTPase 1	Mus musculus	54-58
31243195-12	2019	In conclusion, we reported that increased CCh-induced Rac1 activation via Tiam1 and Trio upregulation, in addition to upregulate Rac1, may be involved in increased CCh-induced BSM contractions in Chal.	Carbachol	164-167	T cell lymphoma invasion and metastasis 1	Mus musculus	74-79
31243195-12	2019	In conclusion, we reported that increased CCh-induced Rac1 activation via Tiam1 and Trio upregulation, in addition to upregulate Rac1, may be involved in increased CCh-induced BSM contractions in Chal.	Carbachol	164-167	triple functional domain (PTPRF interacting)	Mus musculus	84-88
31243195-12	2019	In conclusion, we reported that increased CCh-induced Rac1 activation via Tiam1 and Trio upregulation, in addition to upregulate Rac1, may be involved in increased CCh-induced BSM contractions in Chal.	Carbachol	164-167	Rac family small GTPase 1	Mus musculus	129-133
31227218-4	2019	When SNU-407 cells were treated with the cholinergic agonist carbachol, eEF2 phosphorylation at T56 was decreased in a dose- and time-dependent manner.	Carbachol	61-70	eukaryotic translation elongation factor 2	Homo sapiens	72-76
31227218-5	2019	The muscarinic antagonist atropine almost completely blocked this effect of carbachol, demonstrating that mAChRs specifically regulate eEF2 dephosphorylation.	Carbachol	76-85	eukaryotic translation elongation factor 2	Homo sapiens	135-139
31227218-7	2019	Treating cells with U0126, a potent MEK1/2 inhibitor, decreased carbachol-stimulated eEF2 dephosphorylation.	Carbachol	64-73	mitogen-activated protein kinase kinase 1	Homo sapiens	36-42
31227218-7	2019	Treating cells with U0126, a potent MEK1/2 inhibitor, decreased carbachol-stimulated eEF2 dephosphorylation.	Carbachol	64-73	eukaryotic translation elongation factor 2	Homo sapiens	85-89
31383845-0	2019	Anoctamin 1/TMEM16A controls intestinal Cl- secretion induced by carbachol and cholera toxin.	Carbachol	65-74	anoctamin 1, calcium activated chloride channel	Mus musculus	0-11
31383845-0	2019	Anoctamin 1/TMEM16A controls intestinal Cl- secretion induced by carbachol and cholera toxin.	Carbachol	65-74	anoctamin 1, calcium activated chloride channel	Mus musculus	12-19
31383845-3	2019	Although genetic ablation of ANO1/TMEM16A, a gene encoding a CaCC, reduces the carbachol-induced secretion of intestinal fluid, its mechanism of action is still unknown.	Carbachol	79-88	anoctamin 1, calcium activated chloride channel	Mus musculus	29-33
31383845-3	2019	Although genetic ablation of ANO1/TMEM16A, a gene encoding a CaCC, reduces the carbachol-induced secretion of intestinal fluid, its mechanism of action is still unknown.	Carbachol	79-88	anoctamin 1, calcium activated chloride channel	Mus musculus	34-41
31383845-3	2019	Although genetic ablation of ANO1/TMEM16A, a gene encoding a CaCC, reduces the carbachol-induced secretion of intestinal fluid, its mechanism of action is still unknown.	Carbachol	79-88	chloride channel accessory 3A1	Mus musculus	61-65
31383845-5	2019	Carbachol-induced transepithelial currents were reduced in the proximal colon of Ano1-deficient mice.	Carbachol	0-9	anoctamin 1, calcium activated chloride channel	Mus musculus	81-85
31383845-10	2019	We thus conclude that ANO1 is necessary for cAMP- and carbachol-induced Cl- secretion in the intestine, which is essential for the protection of the intestinal epithelium from colitis.	Carbachol	54-63	anoctamin 1, calcium activated chloride channel	Mus musculus	22-26
30742476-4	2019	Overnight TGF-beta1 treatment significantly impaired isoproterenol (ISO)-induced relaxation of carbachol-stimulated, isolated HASM cells.	Carbachol	95-104	transforming growth factor beta 1	Homo sapiens	10-19
30697954-6	2019	The Rac1 inhibitor EHT1864 inhibited carbachol (CCh)-induced BSM contractions, although high K+ depolarization-induced BSM contractions were not significantly attenuated by EHT1864.	Carbachol	48-51	Rac family small GTPase 1	Mus musculus	4-8
31048413-3	2019	We report here that secretagogues (agonists that stimulate secretion) such as the peptide hormone vasoactive intestinal peptide (VIP) and muscarinic agonist carbachol increase CFTR aggregation into cholesterol-dependent clusters, reduce CFTR lateral mobility within and between membrane microdomains, and trigger the fusion of clusters into large (3.0 microm2) ceramide-rich platforms.	Carbachol	157-166	CF transmembrane conductance regulator	Homo sapiens	176-180
31042424-5	2019	The beta3-AR agonists BRL37344 and CL316243 (100 nM) inhibited cholinergic nerve-mediated contractions of the detrusor by 19 and 23%, respectively, but did not reduce contractions induced by the cholinergic agonist carbachol (300 nM).	Carbachol	215-224	adrenergic receptor, beta 3	Mus musculus	4-12
31048413-3	2019	We report here that secretagogues (agonists that stimulate secretion) such as the peptide hormone vasoactive intestinal peptide (VIP) and muscarinic agonist carbachol increase CFTR aggregation into cholesterol-dependent clusters, reduce CFTR lateral mobility within and between membrane microdomains, and trigger the fusion of clusters into large (3.0 microm2) ceramide-rich platforms.	Carbachol	157-166	CF transmembrane conductance regulator	Homo sapiens	237-241
30382364-11	2019	Deletion of IP3R1 in the GI tract also reduced the contractile response to the muscarinic agonist, carbachol, as well as to electrical field stimulation.	Carbachol	99-108	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	12-17
30120731-4	2019	Mice with a single copy of Gtf2i (Gtf2i+/Del) had increased axonal outgrowth and increased TRPC3-mediated calcium entry upon carbachol stimulation.	Carbachol	125-134	general transcription factor II I	Mus musculus	27-32
30840492-4	2019	Costimulation with carbachol plus the beta-adrenergic agonist isoproterenol decreased the concentration of NaCl and produced a substantial increase in the protein and Ca2+ content of SMG but not SLG saliva, consistent with a sparse sympathetic innervation of the SLGs.	Carbachol	19-28	small nuclear ribonucleoprotein polypeptide G	Mus musculus	183-186
30120731-4	2019	Mice with a single copy of Gtf2i (Gtf2i+/Del) had increased axonal outgrowth and increased TRPC3-mediated calcium entry upon carbachol stimulation.	Carbachol	125-134	general transcription factor II I	Mus musculus	34-39
30120731-4	2019	Mice with a single copy of Gtf2i (Gtf2i+/Del) had increased axonal outgrowth and increased TRPC3-mediated calcium entry upon carbachol stimulation.	Carbachol	125-134	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	91-96
31008485-5	2019	The results showed that, the slope of field excitatory postsynaptic potential (fEPSP) and carbachol-induced theta oscillation were significantly decreased in the hippocampal CA1 neurons of alpha7 KO mice, compared with those of wild type mice.	Carbachol	90-99	carbonic anhydrase 1	Mus musculus	174-177
30872401-4	2019	Here, we found that in human neuroblastoma cells, activation of ADAM10 with the muscarinic agonist carbachol promotes PrPC shedding and reduces the binding of AbetaO to the cell surface, which could be blocked with an ADAM10 inhibitor.	Carbachol	99-108	ADAM metallopeptidase domain 10	Homo sapiens	64-70
30872401-4	2019	Here, we found that in human neuroblastoma cells, activation of ADAM10 with the muscarinic agonist carbachol promotes PrPC shedding and reduces the binding of AbetaO to the cell surface, which could be blocked with an ADAM10 inhibitor.	Carbachol	99-108	prion protein	Homo sapiens	118-122
30872401-4	2019	Here, we found that in human neuroblastoma cells, activation of ADAM10 with the muscarinic agonist carbachol promotes PrPC shedding and reduces the binding of AbetaO to the cell surface, which could be blocked with an ADAM10 inhibitor.	Carbachol	99-108	ADAM metallopeptidase domain 10	Homo sapiens	218-224
30639512-13	2019	Finally, carbachol induced secretion of exosomal NEP in C2C12-derived myotube cells.	Carbachol	9-18	membrane metallo endopeptidase	Mus musculus	49-52
31040768-7	2019	In the current study, an ex vivo drug treatment assay was used to demonstrate that carbachol (CCh)-mediated cholinergic stimulation of the intact adult zebrafish brain induces phosphorylation of GSK3beta and ERK1/2 in the zebrafish telencephalon.	Carbachol	83-92	glycogen synthase kinase 3 beta, genome duplicate a	Danio rerio	195-203
31040768-7	2019	In the current study, an ex vivo drug treatment assay was used to demonstrate that carbachol (CCh)-mediated cholinergic stimulation of the intact adult zebrafish brain induces phosphorylation of GSK3beta and ERK1/2 in the zebrafish telencephalon.	Carbachol	83-92	mitogen-activated protein kinase 3	Danio rerio	208-214
31040768-7	2019	In the current study, an ex vivo drug treatment assay was used to demonstrate that carbachol (CCh)-mediated cholinergic stimulation of the intact adult zebrafish brain induces phosphorylation of GSK3beta and ERK1/2 in the zebrafish telencephalon.	Carbachol	94-97	glycogen synthase kinase 3 beta, genome duplicate a	Danio rerio	195-203
31040768-7	2019	In the current study, an ex vivo drug treatment assay was used to demonstrate that carbachol (CCh)-mediated cholinergic stimulation of the intact adult zebrafish brain induces phosphorylation of GSK3beta and ERK1/2 in the zebrafish telencephalon.	Carbachol	94-97	mitogen-activated protein kinase 3	Danio rerio	208-214
30223917-4	2018	Here we present a reaction for identification of carbamate-type drugs, based on the precipitation of barium carbonate upon treating the analytes with barium hydroxide solution at 80  C. This method works well for carbamate drugs with noteworthy water solubility like carbachol, neostigmine bromide, and pyridostigmine bromide, and could be considered as a method for second identification of these drugs in pharmacopoeias and in Deutscher Arzneimittel-Codex/Neues Rezeptur-Formularium (DAC-NRF).	Carbachol	267-276	arylacetamide deacetylase	Homo sapiens	486-489
30632283-7	2019	RESULTS: 30 muM Mirabegron impaired carbachol (0.03-1 muM)-induced contraction in human detrusor smooth muscle.	Carbachol	36-45	latexin	Homo sapiens	12-15
30632283-7	2019	RESULTS: 30 muM Mirabegron impaired carbachol (0.03-1 muM)-induced contraction in human detrusor smooth muscle.	Carbachol	36-45	latexin	Homo sapiens	54-57
30407877-4	2019	When the mAChR was activated by the agonist carbachol, the colocalization of the M1 mAChR and SUMO-1 protein markedly decreased in immunoprecipitation and immunofluorescence assays.	Carbachol	44-53	small ubiquitin like modifier 1	Homo sapiens	94-100
29927500-7	2018	To pursue how 7,8-DHF could augment CCh-activated PLC-gamma phosphorylation, we first examined the effect of 7,8-DHF on the expression of muscarinic receptors in gastric muscle and found that 7,8-DHF specifically increased M3 but not M2 receptor expression possibly through TrkB/Akt (protein kinase B) pathway because the Akt antagonist, LY294002 significantly suppressed the 7,8-DHF-augmemted M3 expression and completely blocked the 7,8-DHF-enhanced cholinergic contraction.	Carbachol	36-39	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	274-278
29927500-7	2018	To pursue how 7,8-DHF could augment CCh-activated PLC-gamma phosphorylation, we first examined the effect of 7,8-DHF on the expression of muscarinic receptors in gastric muscle and found that 7,8-DHF specifically increased M3 but not M2 receptor expression possibly through TrkB/Akt (protein kinase B) pathway because the Akt antagonist, LY294002 significantly suppressed the 7,8-DHF-augmemted M3 expression and completely blocked the 7,8-DHF-enhanced cholinergic contraction.	Carbachol	36-39	AKT serine/threonine kinase 1	Rattus norvegicus	279-282
29927500-7	2018	To pursue how 7,8-DHF could augment CCh-activated PLC-gamma phosphorylation, we first examined the effect of 7,8-DHF on the expression of muscarinic receptors in gastric muscle and found that 7,8-DHF specifically increased M3 but not M2 receptor expression possibly through TrkB/Akt (protein kinase B) pathway because the Akt antagonist, LY294002 significantly suppressed the 7,8-DHF-augmemted M3 expression and completely blocked the 7,8-DHF-enhanced cholinergic contraction.	Carbachol	36-39	AKT serine/threonine kinase 1	Rattus norvegicus	322-325
30311722-7	2019	In vitro, the RET kinase inhibitor GSK3179106 attenuated the mean increase in Isc induced by either EFS or carbachol but not bethanechol.	Carbachol	107-116	ret proto-oncogene	Rattus norvegicus	14-17
30798915-11	2019	Various compounds that accelerate emergence from anesthesia, thus mitigating problematic effects associated with delayed emergence such as delirium, also activate AMPK (e.g. nicotine, caffeine, forskolin, carbachol).	Carbachol	205-214	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	163-167
30886671-4	2019	We have found that H2O2 in concentration range 10-100 muM increases the rise of [Ca2+]i induced by 5-hydroxytryptamine (5-HT) and carbachol and does not affect the calcium signals of ATP, agonist of type 1 protease-activated receptor SFLLRN, histamine and bradykinin.	Carbachol	130-139	latexin	Homo sapiens	54-57
30834352-5	2019	In CA1 minislices isolated from rat ventral hippocampus slices, MOR activation by DAMGO reduced the dominant frequency of intrinsic fast gamma, induced by carbachol.	Carbachol	155-164	carbonic anhydrase 1	Rattus norvegicus	3-6
30203559-5	2019	Our results showed that high-K+ - or carbachol-induced contractions of mouse ASM were significantly greater after pretreatment with TNF-alpha or IL-8 for 24 hours.	Carbachol	37-46	tumor necrosis factor	Mus musculus	132-141
30203559-5	2019	Our results showed that high-K+ - or carbachol-induced contractions of mouse ASM were significantly greater after pretreatment with TNF-alpha or IL-8 for 24 hours.	Carbachol	37-46	chemokine (C-X-C motif) ligand 15	Mus musculus	145-149
30203559-7	2019	Moreover, TNF-alpha treatment enhanced carbachol-induced Ca2+ influx in ASM cells, and this effect was abrogated by verapamil.	Carbachol	39-48	tumor necrosis factor	Mus musculus	10-19
29959979-3	2018	The cholinergic agonists carbachol and acetylcholine triggered heterogeneous Ca2+ oscillations that were strongly inhibited by antagonists with high affinity for the M3 muscarinic receptor subtype, while preferential block of M1 or M2 receptors was less effective.	Carbachol	25-34	cholinergic receptor muscarinic 3	Homo sapiens	166-188
30618761-7	2018	Carbachol raised [Ca2+]cyt in mouse tracheal smooth muscle cells and induced murine tracheal contraction, all of which were significantly attenuated by KB-R7943, a selective NCX inhibitor.	Carbachol	0-9	T cell leukemia, homeobox 2	Mus musculus	174-177
30160518-5	2018	Phosphorylation of MLC was measured after having been stimulated by carbachol.	Carbachol	68-77	modulator of VRAC current 1	Homo sapiens	19-22
30001145-8	2018	The Gq/11 inhibitor YM-254890 (10 muM) and PLC inhibitor U73122 (1 muM), but not the PKC inhibitor calphostin C (1 muM), markedly decreased CCh-induced suppression of IKATP in WT cells.	Carbachol	140-143	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	43-46
30223917-4	2018	Here we present a reaction for identification of carbamate-type drugs, based on the precipitation of barium carbonate upon treating the analytes with barium hydroxide solution at 80  C. This method works well for carbamate drugs with noteworthy water solubility like carbachol, neostigmine bromide, and pyridostigmine bromide, and could be considered as a method for second identification of these drugs in pharmacopoeias and in Deutscher Arzneimittel-Codex/Neues Rezeptur-Formularium (DAC-NRF).	Carbachol	267-276	NFKB repressing factor	Homo sapiens	490-493
30249045-8	2018	Finally, we used telemetry to monitor heart response to carbachol, a cholinergic receptor agonist, and found that heart rate recovered more quickly in Tbx1+/- animals versus controls.	Carbachol	56-65	T-box 1	Mus musculus	151-155
29561662-4	2018	Therefore, we hypothesized that decreased carbachol (CCH)-stimulated Cl- secretion in DSS-induced colitis could be attributed to a loss of Ca2+-activated Cl- channels (CaCC) in apical membranes of colonic epithelium.	Carbachol	42-51	chloride channel accessory 3A1	Mus musculus	139-166
29561662-4	2018	Therefore, we hypothesized that decreased carbachol (CCH)-stimulated Cl- secretion in DSS-induced colitis could be attributed to a loss of Ca2+-activated Cl- channels (CaCC) in apical membranes of colonic epithelium.	Carbachol	42-51	chloride channel accessory 3A1	Mus musculus	168-172
29561662-4	2018	Therefore, we hypothesized that decreased carbachol (CCH)-stimulated Cl- secretion in DSS-induced colitis could be attributed to a loss of Ca2+-activated Cl- channels (CaCC) in apical membranes of colonic epithelium.	Carbachol	53-56	chloride channel accessory 3A1	Mus musculus	139-166
29561662-4	2018	Therefore, we hypothesized that decreased carbachol (CCH)-stimulated Cl- secretion in DSS-induced colitis could be attributed to a loss of Ca2+-activated Cl- channels (CaCC) in apical membranes of colonic epithelium.	Carbachol	53-56	chloride channel accessory 3A1	Mus musculus	168-172
29471582-7	2018	A significant reduction was observed in STZ-diabetic aortic endothelial cell eNOS and CAV-1 of 40% and 30%, respectively, accompanied by a compromised STZ-diabetic carbachol-induced vasodilation (STZ 29.6 +- 9.3% vs control 77.2 +- 2.5%, P &lt; .001).	Carbachol	164-173	nitric oxide synthase 3	Rattus norvegicus	77-81
29471582-7	2018	A significant reduction was observed in STZ-diabetic aortic endothelial cell eNOS and CAV-1 of 40% and 30%, respectively, accompanied by a compromised STZ-diabetic carbachol-induced vasodilation (STZ 29.6 +- 9.3% vs control 77.2 +- 2.5%, P &lt; .001).	Carbachol	164-173	caveolin 1	Rattus norvegicus	86-91
29668674-4	2018	Consistent with previous findings, mice lacking GIRK4 exhibited diminished HR and HRV responses to the cholinergic agonist carbachol (CCh), and resistance to CCh-induced arrhythmic episodes.	Carbachol	123-132	potassium inwardly-rectifying channel, subfamily J, member 5	Mus musculus	48-53
29527918-8	2018	In carbachol pre-stimulated ciliary muscle, UCN2 (10(-5) M) enhanced contraction (maximal effect of 18.2 % increase vs. control).	Carbachol	3-12	urocortin 2	Bos taurus	44-48
29527918-10	2018	Regarding ciliary muscle, UCN2 enhances carbachol-induced contraction, in higher doses.	Carbachol	40-49	urocortin 2	Bos taurus	26-30
29211339-0	2018	beta3-adrenoceptor agonists inhibit carbachol-evoked Ca2+ oscillations in murine detrusor myocytes.	Carbachol	36-45	adrenergic receptor, beta 3	Mus musculus	0-18
29211339-6	2018	The selective beta3-AR agonist BRL37344 reduced the amplitude of CCh-induced contractions of detrusor smooth muscle.	Carbachol	65-68	adrenergic receptor, beta 3	Mus musculus	14-22
29676804-7	2018	The CCh-induced salivary flow was suppressed by phlorizin, an inhibitor of the sodium-glucose cotransporter 1 (SGLT1) located basolaterally in submandibular acinar cells, which is altered at the protein expression level in diabetic animal models.	Carbachol	4-7	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	79-109
29676804-7	2018	The CCh-induced salivary flow was suppressed by phlorizin, an inhibitor of the sodium-glucose cotransporter 1 (SGLT1) located basolaterally in submandibular acinar cells, which is altered at the protein expression level in diabetic animal models.	Carbachol	4-7	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	111-116
28984468-5	2018	In human precision-cut lung slices, overnight treatment with TGF-beta1 significantly augmented basal and carbachol-induced bronchoconstriction.	Carbachol	105-114	transforming growth factor beta 1	Homo sapiens	61-70
29401590-7	2018	Activation of Galphaq by carbachol causes movement of PLCbeta from the cytosol to the plasma membrane, reducing its association with CDK16.	Carbachol	25-34	G protein subunit alpha q	Homo sapiens	14-21
29401590-7	2018	Activation of Galphaq by carbachol causes movement of PLCbeta from the cytosol to the plasma membrane, reducing its association with CDK16.	Carbachol	25-34	cyclin dependent kinase 16	Homo sapiens	133-138
29430647-8	2018	Drugs that block Ano1 inhibited the conductance activated by carbachol in ICC-IM and EJPs and mechanical responses in tissues.	Carbachol	61-70	anoctamin 1, calcium activated chloride channel	Mus musculus	17-21
29792810-5	2018	RGS2 reduced the stochasticity of carbachol-stimulated calcium oscillations, and the feedback inhibition was coupled to the global calcium elevation by calmodulin/RGS2 interactions.	Carbachol	34-43	regulator of G protein signaling 2	Homo sapiens	0-4
29915209-6	2018	Cholinergic responses, induced by electric-field stimulation (EFS), bath application of the cholinergic agonist carbachol, or the acetylcholinesterase inhibitor neostigmine were all significantly smaller in TRPC4-/- detrusor strips than wild-type.	Carbachol	112-121	transient receptor potential cation channel, subfamily C, member 4	Mus musculus	207-212
29668674-4	2018	Consistent with previous findings, mice lacking GIRK4 exhibited diminished HR and HRV responses to the cholinergic agonist carbachol (CCh), and resistance to CCh-induced arrhythmic episodes.	Carbachol	134-137	potassium inwardly-rectifying channel, subfamily J, member 5	Mus musculus	48-53
29668674-4	2018	Consistent with previous findings, mice lacking GIRK4 exhibited diminished HR and HRV responses to the cholinergic agonist carbachol (CCh), and resistance to CCh-induced arrhythmic episodes.	Carbachol	158-161	potassium inwardly-rectifying channel, subfamily J, member 5	Mus musculus	48-53
29668674-5	2018	In line with its role as a negative regulator of atrial M2R-IKACh signaling, loss of RGS6 correlated with a mild resting bradycardia, enhanced HR and HRV responses to CCh, and increased propensity for arrhythmic episodes.	Carbachol	167-170	regulator of G-protein signaling 6	Mus musculus	85-89
29668674-6	2018	Interestingly, ventricles from mice lacking GIRK4 or RGS6 both exhibited increased action potential duration (APD) at baseline, and APD was prolonged by CCh across all genotypes.	Carbachol	153-156	potassium inwardly-rectifying channel, subfamily J, member 5	Mus musculus	44-49
29463029-6	2018	HEK293 cells deficient in a penta-EF-hand Ca2+-binding protein ALG-2 showed a higher RLA value than the parental cells by stimulation with an acetylcholine receptor agonist carbachol.	Carbachol	173-182	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	63-68
29055784-5	2018	Our results demonstrated that muscle contractions induced by carbachol (CCh) and endothelin-1 (ET-1) were inhibited by EHT1864, a selective Rac1 inhibitor, and NSC23766, a selective inhibitor of Rac1-specific guanine nucleotide exchange factors.	Carbachol	61-70	Rac family small GTPase 1	Rattus norvegicus	140-144
29352184-4	2018	The cholinergic agonist carbachol (CCh) activated small GIRK currents in adult wild-type ventricular myocytes that exhibited relatively slow kinetics and low CCh sensitivity; these currents were absent in ventricular myocytes from Girk1-/- or Girk4-/- mice.	Carbachol	24-33	potassium inwardly-rectifying channel, subfamily J, member 3	Mus musculus	231-236
29055784-5	2018	Our results demonstrated that muscle contractions induced by carbachol (CCh) and endothelin-1 (ET-1) were inhibited by EHT1864, a selective Rac1 inhibitor, and NSC23766, a selective inhibitor of Rac1-specific guanine nucleotide exchange factors.	Carbachol	61-70	Rac family small GTPase 1	Rattus norvegicus	195-199
29352184-4	2018	The cholinergic agonist carbachol (CCh) activated small GIRK currents in adult wild-type ventricular myocytes that exhibited relatively slow kinetics and low CCh sensitivity; these currents were absent in ventricular myocytes from Girk1-/- or Girk4-/- mice.	Carbachol	24-33	potassium inwardly-rectifying channel, subfamily J, member 5	Mus musculus	243-248
29352184-4	2018	The cholinergic agonist carbachol (CCh) activated small GIRK currents in adult wild-type ventricular myocytes that exhibited relatively slow kinetics and low CCh sensitivity; these currents were absent in ventricular myocytes from Girk1-/- or Girk4-/- mice.	Carbachol	35-38	potassium inwardly-rectifying channel, subfamily J, member 3	Mus musculus	231-236
29352184-4	2018	The cholinergic agonist carbachol (CCh) activated small GIRK currents in adult wild-type ventricular myocytes that exhibited relatively slow kinetics and low CCh sensitivity; these currents were absent in ventricular myocytes from Girk1-/- or Girk4-/- mice.	Carbachol	35-38	potassium inwardly-rectifying channel, subfamily J, member 5	Mus musculus	243-248
29122814-7	2018	We found that arteries from EC Calr Delta/Delta mice stimulated with CCh had unchanged activity of calcium signals and vasodilation; however, the same arteries were unable to increase calcium events at HIEL in response to PE.	Carbachol	69-72	calreticulin	Mus musculus	31-35
29055784-5	2018	Our results demonstrated that muscle contractions induced by carbachol (CCh) and endothelin-1 (ET-1) were inhibited by EHT1864, a selective Rac1 inhibitor, and NSC23766, a selective inhibitor of Rac1-specific guanine nucleotide exchange factors.	Carbachol	72-75	Rac family small GTPase 1	Rattus norvegicus	140-144
29055784-5	2018	Our results demonstrated that muscle contractions induced by carbachol (CCh) and endothelin-1 (ET-1) were inhibited by EHT1864, a selective Rac1 inhibitor, and NSC23766, a selective inhibitor of Rac1-specific guanine nucleotide exchange factors.	Carbachol	72-75	Rac family small GTPase 1	Rattus norvegicus	195-199
29055784-11	2018	These results suggest that Rac1, activated by G protein-coupled receptor agonists, such as CCh and ET-1, may induce myosin light chain and MYPT phosphorylation and modulate the contraction of bronchial smooth muscle.	Carbachol	91-94	Rac family small GTPase 1	Rattus norvegicus	27-31
28972132-6	2017	LRRC8B-overexpressing cells exhibited a lesser release of Ca2+ from the ER in response to ATP, carbachol and intracellular administration of inositol (1,4,5)-trisphosphate (IP3).	Carbachol	95-104	leucine rich repeat containing 8 VRAC subunit B	Homo sapiens	0-6
29042271-4	2018	Intra-LH microinjection of carbachol was done 5min after intra-CA1 administration of SB-334867 (OX1R antagonist) or TCS OX2 29 (OX2R antagonist).	Carbachol	27-36	hypocretin receptor 1	Rattus norvegicus	96-100
29042438-5	2017	In isolated pancreatic lobules, pretreatment with recombinant human renalase (rRNLS) blocked zymogen activation caused by cerulein, carbachol, and a bile acid.	Carbachol	132-141	renalase, FAD dependent amine oxidase	Homo sapiens	68-76
29270134-2	2017	Our previous in vitro studies with molecular approaches on AR42J cell showed that protein kinase D (PKD/PKD1) activation was required in NF-kappaB activation induced by cholecystokinin 8 (CCK) or carbachol (CCh) in pancreatic acinar cells.	Carbachol	196-205	polycystin 1, transient receptor potential channel interacting	Rattus norvegicus	104-108
29270134-2	2017	Our previous in vitro studies with molecular approaches on AR42J cell showed that protein kinase D (PKD/PKD1) activation was required in NF-kappaB activation induced by cholecystokinin 8 (CCK) or carbachol (CCh) in pancreatic acinar cells.	Carbachol	207-210	polycystin 1, transient receptor potential channel interacting	Rattus norvegicus	104-108
29270134-2	2017	Our previous in vitro studies with molecular approaches on AR42J cell showed that protein kinase D (PKD/PKD1) activation was required in NF-kappaB activation induced by cholecystokinin 8 (CCK) or carbachol (CCh) in pancreatic acinar cells.	Carbachol	207-210	cholecystokinin	Rattus norvegicus	188-191
29208957-7	2017	In isolated islets, carbachol and PACAP/VIP synergistically promote beta-cell proliferation through a FoxM1-dependent mechanism.	Carbachol	20-29	forkhead box M1	Mus musculus	102-107
28921504-10	2017	Galpha12 coimmunoprecipitated with M3 receptors, and p115RhoGEF-RGS overexpression inhibited carbachol-mediated induction of SRE-luciferase reporter.	Carbachol	93-102	Rho guanine nucleotide exchange factor 1	Homo sapiens	53-63
28921504-10	2017	Galpha12 coimmunoprecipitated with M3 receptors, and p115RhoGEF-RGS overexpression inhibited carbachol-mediated induction of SRE-luciferase reporter.	Carbachol	93-102	paired like homeodomain 2	Homo sapiens	64-67
28921504-11	2017	p115RhoGEF-RGS overexpression inhibited carbachol-induced activation of Akt, HASMC contraction, and shortening.	Carbachol	40-49	Rho guanine nucleotide exchange factor 1	Homo sapiens	0-10
28921504-11	2017	p115RhoGEF-RGS overexpression inhibited carbachol-induced activation of Akt, HASMC contraction, and shortening.	Carbachol	40-49	paired like homeodomain 2	Homo sapiens	11-14
28921504-11	2017	p115RhoGEF-RGS overexpression inhibited carbachol-induced activation of Akt, HASMC contraction, and shortening.	Carbachol	40-49	AKT serine/threonine kinase 1	Homo sapiens	72-75
29142468-10	2017	In the presence of guanethidine and carbachol, the addition of GLP-2 to the bath medium evoked TTX-sensitive relaxant responses that were unaffected by L-NNA (P &gt; 0.05).	Carbachol	36-45	glucagon-like peptide 2 receptor	Mus musculus	63-68
28893976-6	2017	Stimulation of cells overexpressing M1R or M3R with CCh resulted in a similar reduction in phosphatidylinositol 4,5-bisphosphate (PIP2).	Carbachol	52-55	cholinergic receptor, muscarinic 1, CNS	Mus musculus	36-39
28893976-6	2017	Stimulation of cells overexpressing M1R or M3R with CCh resulted in a similar reduction in phosphatidylinositol 4,5-bisphosphate (PIP2).	Carbachol	52-55	cholinergic receptor, muscarinic 3, cardiac	Mus musculus	43-46
28893976-8	2017	Moreover, pilocarpine blocked CCh-stimulated PIP2 hydrolysis in M3R-overexpressing cells, thus, it acted as an antagonist.	Carbachol	30-33	cholinergic receptor, muscarinic 3, cardiac	Mus musculus	64-67
28798231-7	2017	Lastly, in vivo administration of the P2X7R antagonist A438079 in the CD28-/-, IFNgamma-/-, NOD.H-2h4 mouse model of salivary gland exocrinopathy ameliorated salivary gland inflammation and enhanced carbachol-induced saliva secretion.	Carbachol	199-208	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	38-43
28645101-0	2017	Co-localization of endogenous Arf6 and its activator EFA6D in the granular convoluted tubule cells of mouse submandibular glands under normal conditions and when stimulated by isoproterenol, noradrenaline and carbachol.	Carbachol	209-218	ADP-ribosylation factor 6	Mus musculus	30-34
28971603-4	2017	Carbachol (CCh)-induced contraction in rabbit muscle strips and isolated muscle cells was inhibited by l-cysteine (substrate of CSE) and NaHS (an exogenous H2 S donor) in a concentration-dependent fashion.	Carbachol	0-9	cystathionine gamma-lyase	Oryctolagus cuniculus	128-131
28971603-4	2017	Carbachol (CCh)-induced contraction in rabbit muscle strips and isolated muscle cells was inhibited by l-cysteine (substrate of CSE) and NaHS (an exogenous H2 S donor) in a concentration-dependent fashion.	Carbachol	11-14	cystathionine gamma-lyase	Oryctolagus cuniculus	128-131
28971603-6	2017	CCh-induced Rho kinase activity also was inhibited by l-cysteine and NaHS in a concentration-dependent fashion.	Carbachol	0-3	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	12-22
28971603-7	2017	Inhibition of CCh-induced contraction by l-cysteine was blocked by the CSE inhibitor, dl-propargylglycine (DL-PPG) in dispersed muscle cells.	Carbachol	14-17	cystathionine gamma-lyase	Oryctolagus cuniculus	71-74
28971603-7	2017	Inhibition of CCh-induced contraction by l-cysteine was blocked by the CSE inhibitor, dl-propargylglycine (DL-PPG) in dispersed muscle cells.	Carbachol	14-17	serglycin	Homo sapiens	110-113
28971603-8	2017	Inhibition of CCh-induced Rho kinase activity by l-cysteine was blocked by CSE siRNA in cultured cells and DL-PPG in dispersed muscle cells.	Carbachol	14-17	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	26-36
28971603-8	2017	Inhibition of CCh-induced Rho kinase activity by l-cysteine was blocked by CSE siRNA in cultured cells and DL-PPG in dispersed muscle cells.	Carbachol	14-17	cystathionine gamma-lyase	Oryctolagus cuniculus	75-78
28971603-8	2017	Inhibition of CCh-induced Rho kinase activity by l-cysteine was blocked by CSE siRNA in cultured cells and DL-PPG in dispersed muscle cells.	Carbachol	14-17	serglycin	Homo sapiens	110-113
28971603-9	2017	Stimulation of Rho kinase activity and muscle contraction in response to CCh was also inhibited by l-cysteine or NaHS in colonic muscle cells from mouse and human.	Carbachol	73-76	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	15-25
28749013-3	2017	Concentration/temporal responses to carbachol demonstrated similar sensitivities for bovine tracheal force development and phosphorylation of RLC, MYPT1, MBS85 and paxillin.	Carbachol	36-45	protein phosphatase 1, regulatory subunit 12A	Mus musculus	147-152
28749013-3	2017	Concentration/temporal responses to carbachol demonstrated similar sensitivities for bovine tracheal force development and phosphorylation of RLC, MYPT1, MBS85 and paxillin.	Carbachol	36-45	protein phosphatase 1, regulatory subunit 12C	Mus musculus	154-159
28645101-0	2017	Co-localization of endogenous Arf6 and its activator EFA6D in the granular convoluted tubule cells of mouse submandibular glands under normal conditions and when stimulated by isoproterenol, noradrenaline and carbachol.	Carbachol	209-218	pleckstrin and Sec7 domain containing 3	Mus musculus	53-58
29033789-5	2017	We report that multiple, unpredictable exposure to stress depresses carbachol (0.5 muM)-induced mLTP, while this effect of stress is not observed in hippocampal slices prepared from mice exposed only to a single stressful procedure.	Carbachol	68-77	liver transport protein	Mus musculus	96-100
28966579-7	2017	Inhibition of the MS with muscimol pre-treatment attenuated both carbachol-evoked c-Fos-ir and theta activation.	Carbachol	65-74	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	82-87
28902875-6	2017	Although total cellular cathepsin S activity was not commensurately increased, IFN-gamma treated lacrimal gland acinar cells showed a significant increase in carbachol-stimulated secretion of cathepsin S similar to the lacrimal gland in disease.	Carbachol	158-167	interferon gamma	Mus musculus	79-88
28902875-6	2017	Although total cellular cathepsin S activity was not commensurately increased, IFN-gamma treated lacrimal gland acinar cells showed a significant increase in carbachol-stimulated secretion of cathepsin S similar to the lacrimal gland in disease.	Carbachol	158-167	cathepsin S	Oryctolagus cuniculus	192-203
28495796-3	2017	NHE3-S719A but not -S719D had multiple changes in NHE3 activity: 1) reduced basal NHE3 activity-specifically, inhibition of the PI3K/AKT-dependent component; 2) reduced acute stimulation of NHE3 activity by LPA/LPA5R stimulation; and 3) reduced acute inhibition of NHE3 activity-specifically, elevated Ca2+ related (carbachol/Ca2+ ionophore), but there was normal inhibition by forskolin and hyperosmolarity.	Carbachol	316-325	solute carrier family 9 member A3	Homo sapiens	50-54
28549258-0	2017	Immunohistochemical localization of cannabinoid receptor 1 (CB1) in the submandibular gland of mice under normal conditions and when stimulated by isoproterenol or carbachol.	Carbachol	164-173	cannabinoid receptor 1 (brain)	Mus musculus	36-58
28549258-0	2017	Immunohistochemical localization of cannabinoid receptor 1 (CB1) in the submandibular gland of mice under normal conditions and when stimulated by isoproterenol or carbachol.	Carbachol	164-173	cannabinoid receptor 1 (brain)	Mus musculus	60-63
28786172-8	2017	Electrophysiological results demonstrated that in the hippocampal CA3-CA1 synapses of young Apoe4 mice, basic synaptic transmission, and paired-pulse facilitation were enhanced but long-term potentiation and carbachol-induced hippocampal theta oscillations were impaired compared to young Apoe3 mice.	Carbachol	208-217	carbonic anhydrase 3	Mus musculus	66-73
28786172-8	2017	Electrophysiological results demonstrated that in the hippocampal CA3-CA1 synapses of young Apoe4 mice, basic synaptic transmission, and paired-pulse facilitation were enhanced but long-term potentiation and carbachol-induced hippocampal theta oscillations were impaired compared to young Apoe3 mice.	Carbachol	208-217	apolipoprotein E	Homo sapiens	92-97
28687907-5	2017	Besides, the carbachol-stimulated [35S]GTPgammaS binding to Galphaq was competitively antagonized by telenzepine (with a pA 2 value of 8.81), indicating the involvement of the M1 muscarinic acetylcholine receptor (mAChR).	Carbachol	13-22	G protein subunit alpha q	Homo sapiens	60-67
28687907-8	2017	When the pharmacological parameters were correlated with age, postmortem delay, freezing storage period, and tissue pH, no statistically significant correlation was observed except for the negative correlation between age and %E max value of carbachol-stimulated [35S]GTPgammaS binding to Galphaq.	Carbachol	242-251	G protein subunit alpha q	Homo sapiens	289-296
28736134-7	2017	In neuroblastoma cells expressing epitope tagged-Arc, we demonstrate ERK-dependent phosphorylation of Arc in response to activation of muscarinic cholinergic receptors with carbachol.	Carbachol	173-182	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	49-52
28736134-7	2017	In neuroblastoma cells expressing epitope tagged-Arc, we demonstrate ERK-dependent phosphorylation of Arc in response to activation of muscarinic cholinergic receptors with carbachol.	Carbachol	173-182	Eph receptor B1	Rattus norvegicus	69-72
28736134-7	2017	In neuroblastoma cells expressing epitope tagged-Arc, we demonstrate ERK-dependent phosphorylation of Arc in response to activation of muscarinic cholinergic receptors with carbachol.	Carbachol	173-182	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	102-105
28495999-10	2017	Potential beta-arrestin signaling-mediated increases in hERG and IKr were also observed in hERG-HEK cells as well as in neonatal rat ventricular myocytes treated with the muscarinic agonist carbachol.	Carbachol	190-199	ETS transcription factor ERG	Homo sapiens	56-60
28687079-8	2017	Cilostamide, a specific inhibitor for PDE3, significantly inhibited the amplitude and frequency of carbachol-enhanced phasic contractions of neonatal rat bladder strips by 38.8% and 12.1%, respectively.	Carbachol	99-108	phosphodiesterase 4D, cAMP-specific-like 1	Rattus norvegicus	38-42
28495796-3	2017	NHE3-S719A but not -S719D had multiple changes in NHE3 activity: 1) reduced basal NHE3 activity-specifically, inhibition of the PI3K/AKT-dependent component; 2) reduced acute stimulation of NHE3 activity by LPA/LPA5R stimulation; and 3) reduced acute inhibition of NHE3 activity-specifically, elevated Ca2+ related (carbachol/Ca2+ ionophore), but there was normal inhibition by forskolin and hyperosmolarity.	Carbachol	316-325	solute carrier family 9 member A3	Homo sapiens	0-4
28495796-3	2017	NHE3-S719A but not -S719D had multiple changes in NHE3 activity: 1) reduced basal NHE3 activity-specifically, inhibition of the PI3K/AKT-dependent component; 2) reduced acute stimulation of NHE3 activity by LPA/LPA5R stimulation; and 3) reduced acute inhibition of NHE3 activity-specifically, elevated Ca2+ related (carbachol/Ca2+ ionophore), but there was normal inhibition by forskolin and hyperosmolarity.	Carbachol	316-325	solute carrier family 9 member A3	Homo sapiens	50-54
28495796-3	2017	NHE3-S719A but not -S719D had multiple changes in NHE3 activity: 1) reduced basal NHE3 activity-specifically, inhibition of the PI3K/AKT-dependent component; 2) reduced acute stimulation of NHE3 activity by LPA/LPA5R stimulation; and 3) reduced acute inhibition of NHE3 activity-specifically, elevated Ca2+ related (carbachol/Ca2+ ionophore), but there was normal inhibition by forskolin and hyperosmolarity.	Carbachol	316-325	solute carrier family 9 member A3	Homo sapiens	50-54
28495796-3	2017	NHE3-S719A but not -S719D had multiple changes in NHE3 activity: 1) reduced basal NHE3 activity-specifically, inhibition of the PI3K/AKT-dependent component; 2) reduced acute stimulation of NHE3 activity by LPA/LPA5R stimulation; and 3) reduced acute inhibition of NHE3 activity-specifically, elevated Ca2+ related (carbachol/Ca2+ ionophore), but there was normal inhibition by forskolin and hyperosmolarity.	Carbachol	316-325	solute carrier family 9 member A3	Homo sapiens	50-54
28406538-4	2017	Here, we find that the power, but not frequency, of optogenetically induced gamma oscillations in the CA3 region of mouse hippocampal slices is enhanced by low concentrations of the broad-spectrum cholinergic agonist carbachol but reduced at higher concentrations.	Carbachol	217-226	carbonic anhydrase 3	Mus musculus	102-105
28332063-8	2017	Moreover, activation of muscarinic acetylcholine receptor (mAChR) by carbachol directly decreased the interaction between ZO-1 and occludin and increased the acinar TJ width in the freshly isolated human SMGs, whereas these effects were abolished by pretreatment with CK2 inhibitor.	Carbachol	69-78	tight junction protein 1	Homo sapiens	122-126
28332063-8	2017	Moreover, activation of muscarinic acetylcholine receptor (mAChR) by carbachol directly decreased the interaction between ZO-1 and occludin and increased the acinar TJ width in the freshly isolated human SMGs, whereas these effects were abolished by pretreatment with CK2 inhibitor.	Carbachol	69-78	occludin	Homo sapiens	131-139
28496430-11	2017	Both nicotine and carbachol induced intracellular Ca2+ transients in trigeminal neurons partially overlapping with expression of capsaicin-sensitive TRPV1 receptors.	Carbachol	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	149-154
28496430-1	2017	BACKGROUND: Parasympathetic innervation of meninges and ability of carbachol, acetylcholine (ACh) receptor (AChR) agonist, to induce headaches suggests contribution of cholinergic mechanisms to primary headaches.	Carbachol	67-76	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	108-112
28223240-7	2017	Our results suggest that in the presence of carbachol both subiculum and CA3 most often drive theta generators in the entorhinal cortex and that these oscillations are influenced but not abolished by altering GABAA receptor signaling.	Carbachol	44-53	carbonic anhydrase 3	Homo sapiens	73-76
28411158-9	2017	vGluT2+ neurons located in ventromedial regions of BF (in or adjacent to the horizontal limb of the diagonal band) were strongly hyperpolarized by the cholinergic agonist, carbachol, a finding apparently in conflict with their increased discharge during wakefulness/REM sleep and hypothesized role in wake-promotion.	Carbachol	172-181	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	Mus musculus	0-6
27936472-8	2017	High KCl or carbachol-evoked elevation in the intracellular Ca2+ concentration was also abrogated by sodium tanshinone IIA sulphonate in tracheal smooth muscle cells.	Carbachol	12-21	ATPase, class II, type 9A	Mus musculus	119-122
28428632-6	2017	Carbachol (CCH) and forskolin (FSK) exerted significant effects on bladder ICC-LC [Ca2+]i in CYP-treated wild-type (WT) mice, and HCN1 channel ablation significantly decreased the effects of CCH and FSK on bladder ICC-LC [Ca2+]i in both naive and CYP-treated mice.	Carbachol	11-14	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	130-134
28428632-6	2017	Carbachol (CCH) and forskolin (FSK) exerted significant effects on bladder ICC-LC [Ca2+]i in CYP-treated wild-type (WT) mice, and HCN1 channel ablation significantly decreased the effects of CCH and FSK on bladder ICC-LC [Ca2+]i in both naive and CYP-treated mice.	Carbachol	191-194	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	130-134
27906750-3	2017	Our previous study showed that chemical stimulation of the lateral hypothalamus with carbachol induces antinociception in the tail-flick test, a model of acute pain, and Ox1r-mediated antinociception in the vlPAG is modulated by the activity of vlPAG CB1 receptors.	Carbachol	85-94	hypocretin receptor 1	Rattus norvegicus	170-174
28539832-7	2017	We further demonstrated that vascular smooth muscle cells derived from FBN1-mutant iPSCs showed less sensitivity to carbachol as demonstrated by contractility and Ca2+ influx assay, compared to the isogenic controls cells.	Carbachol	116-125	fibrillin 1	Homo sapiens	71-75
28284212-0	2017	Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.	Carbachol	55-64	mitogen-activated protein kinase 7	Homo sapiens	73-77
28284212-8	2017	Blockade of autocrine TGF-beta1 attenuated CCh-mediated fibrotic responses, while TGF-beta1 did not stimulate acetylcholine release.	Carbachol	43-46	transforming growth factor beta 1	Homo sapiens	22-31
28284212-9	2017	Glycopyrronium plus indacaterol significantly attenuated CCh- and TGF-beta1-mediated fibrotic responses through inhibition of ERK5 phosphorylation.	Carbachol	57-60	mitogen-activated protein kinase 7	Homo sapiens	126-130
28284212-10	2017	Notably, the magnitudes of CCh- and TGF-beta1-stimulated gel contraction, CCh-induced TGF-beta1 release, and ERK5 phosphorylation were greater in fibroblasts isolated from COPD subjects than in those from non-smokers.	Carbachol	74-77	transforming growth factor beta 1	Homo sapiens	86-95
28284212-11	2017	CONCLUSIONS: CCh induced TGF-beta1 self-sustaining signaling loops by potentiating ERK5 signaling and promoted myofibroblast activity.	Carbachol	13-16	transforming growth factor beta 1	Homo sapiens	25-34
28284212-11	2017	CONCLUSIONS: CCh induced TGF-beta1 self-sustaining signaling loops by potentiating ERK5 signaling and promoted myofibroblast activity.	Carbachol	13-16	mitogen-activated protein kinase 7	Homo sapiens	83-87
28057557-8	2017	Whereas 100 muM chelerythrine (an inhibitor of PKC) and 100 muM carbachol (an activator of PLC) and 20 muM PD-98059 (an inhibitor of MEK) had additive effects on propofol-induced inhibition of ERK1/2 phosphorylation.	Carbachol	64-73	mitogen-activated protein kinase 3	Mus musculus	193-199
27979597-5	2017	BTP2 inhibited carbachol-activated TRPC3 and TRPC6 channel activities in HEK293 cells.	Carbachol	15-24	transient receptor potential cation channel subfamily C member 3	Homo sapiens	35-40
27979597-5	2017	BTP2 inhibited carbachol-activated TRPC3 and TRPC6 channel activities in HEK293 cells.	Carbachol	15-24	transient receptor potential cation channel subfamily C member 6	Homo sapiens	45-50
28276525-5	2017	The muscarinic agonist carbachol, but not photic stimulation, phase-shifted Bmal1 transcriptional rhythms with a type-1 phase response curve.	Carbachol	23-32	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	76-81
28280417-7	2017	Furthermore, H2O2-induced elevation of intracellular Ca2+ levels was abolished under sarco/endoplasmic reticulum Ca2+ ATPase-inactivated condition by TG pretreatment with CCh.	Carbachol	171-174	ATPase, Ca++ transporting, ubiquitous	Mus musculus	85-124
27765842-6	2017	In isolated soleus muscle, clenbuterol, a selective beta2-adrenoceptor agonist, reduced the basal Ca2+-dependent proteolysis and completely abolished the activation of this pathway by the cholinergic agonist carbachol.	Carbachol	208-217	adrenoceptor beta 2	Rattus norvegicus	52-70
28099849-3	2017	PTH alone had no effect on the cytosolic Ca2+ concentration, but it potentiated the Ca2+ signals evoked by carbachol.	Carbachol	107-116	parathyroid hormone	Homo sapiens	0-3
28099849-6	2017	We conclude that Ca2+ stores within the ER that dynamically exchange Ca2+ with the cytosol maintain a functional independence that allows one store to be released by carbachol and another to be released by carbachol with PTH.	Carbachol	206-215	parathyroid hormone	Homo sapiens	221-224
27906750-3	2017	Our previous study showed that chemical stimulation of the lateral hypothalamus with carbachol induces antinociception in the tail-flick test, a model of acute pain, and Ox1r-mediated antinociception in the vlPAG is modulated by the activity of vlPAG CB1 receptors.	Carbachol	85-94	cannabinoid receptor 1	Rattus norvegicus	251-254
27773818-7	2016	We also observed that the inhibition of protein kinase C (PKC) by GF109203X greatly diminished carbachol-stimulated eIF4B phosphorylation.	Carbachol	95-104	eukaryotic translation initiation factor 4B	Homo sapiens	116-121
27606721-2	2017	Additional studies report the proliferative effect of the cholinergic agonist carbachol on prostate cancer by its agonistic action on CHRM3.	Carbachol	78-87	cholinergic receptor muscarinic 3	Homo sapiens	134-139
27167250-4	2016	When the cells were treated with the cholinergic agonist carbachol, Akt was activated in a dose- and time-dependent fashion.	Carbachol	57-66	AKT serine/threonine kinase 1	Homo sapiens	68-71
27167250-5	2016	This carbachol effect was almost completely blocked by the PI3K inhibitor LY294002, implying that PI3K is responsible for the Akt activation.	Carbachol	5-14	AKT serine/threonine kinase 1	Homo sapiens	126-129
27167250-6	2016	S6K1, a major downstream target of mTORC1, was also activated by carbachol in a temporal profile similar to that of the Akt activation.	Carbachol	65-74	ribosomal protein S6 kinase B1	Homo sapiens	0-4
27167250-6	2016	S6K1, a major downstream target of mTORC1, was also activated by carbachol in a temporal profile similar to that of the Akt activation.	Carbachol	65-74	CREB regulated transcription coactivator 1	Mus musculus	35-41
27167250-7	2016	This carbachol-stimulated S6K1 activation was abrogated by LY294002 or the mTORC1 inhibitor rapamycin, supporting the notion that mAChRs mediate S6K1 activation via the PI3K-Akt-mTORC1 pathway.	Carbachol	5-14	ribosomal protein S6 kinase B1	Homo sapiens	26-30
27167250-7	2016	This carbachol-stimulated S6K1 activation was abrogated by LY294002 or the mTORC1 inhibitor rapamycin, supporting the notion that mAChRs mediate S6K1 activation via the PI3K-Akt-mTORC1 pathway.	Carbachol	5-14	CREB regulated transcription coactivator 1	Mus musculus	75-81
27167250-7	2016	This carbachol-stimulated S6K1 activation was abrogated by LY294002 or the mTORC1 inhibitor rapamycin, supporting the notion that mAChRs mediate S6K1 activation via the PI3K-Akt-mTORC1 pathway.	Carbachol	5-14	ribosomal protein S6 kinase B1	Homo sapiens	145-149
27167250-7	2016	This carbachol-stimulated S6K1 activation was abrogated by LY294002 or the mTORC1 inhibitor rapamycin, supporting the notion that mAChRs mediate S6K1 activation via the PI3K-Akt-mTORC1 pathway.	Carbachol	5-14	AKT serine/threonine kinase 1	Homo sapiens	174-177
27167250-7	2016	This carbachol-stimulated S6K1 activation was abrogated by LY294002 or the mTORC1 inhibitor rapamycin, supporting the notion that mAChRs mediate S6K1 activation via the PI3K-Akt-mTORC1 pathway.	Carbachol	5-14	CREB regulated transcription coactivator 1	Mus musculus	178-184
27167250-9	2016	Inhibition experiments indicated that the ERK1/2 and mTORC1 signaling pathways may be involved in carbachol-stimulated global protein biosynthesis.	Carbachol	98-107	mitogen-activated protein kinase 3	Homo sapiens	42-48
27167250-9	2016	Inhibition experiments indicated that the ERK1/2 and mTORC1 signaling pathways may be involved in carbachol-stimulated global protein biosynthesis.	Carbachol	98-107	CREB regulated transcription coactivator 1	Mus musculus	53-59
27803431-3	2016	Recently, carbachol was reported to stabilize the wild-type hERG-FLAG via activation of the muscarinic type 3 receptor (M3-mAChR).	Carbachol	10-19	ETS transcription factor ERG	Homo sapiens	60-64
27803431-6	2016	Carbachol restored stability of the mutant hERG-FLAG and facilitated cell-surface expression.	Carbachol	0-9	ETS transcription factor ERG	Homo sapiens	43-47
27803431-7	2016	Carbachol activated PKC, augmented phosphorylation of heat shock factor 1 (HSF1) and enhanced expression of heat shock proteins (hsps), hsp70 and hsp90.	Carbachol	0-9	heat shock transcription factor 1	Homo sapiens	54-73
27803431-7	2016	Carbachol activated PKC, augmented phosphorylation of heat shock factor 1 (HSF1) and enhanced expression of heat shock proteins (hsps), hsp70 and hsp90.	Carbachol	0-9	heat shock transcription factor 1	Homo sapiens	75-79
27803431-7	2016	Carbachol activated PKC, augmented phosphorylation of heat shock factor 1 (HSF1) and enhanced expression of heat shock proteins (hsps), hsp70 and hsp90.	Carbachol	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	136-141
27803431-7	2016	Carbachol activated PKC, augmented phosphorylation of heat shock factor 1 (HSF1) and enhanced expression of heat shock proteins (hsps), hsp70 and hsp90.	Carbachol	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	146-151
27803431-8	2016	Both a M3-mAChR antagonist, 4-DAMP, and a PKC inhibitor, bisindolylmaleimide, abolished carbachol-induced stabilization of the mutant hERG-FLAG.	Carbachol	88-97	ETS transcription factor ERG	Homo sapiens	134-138
27287524-6	2016	RESULTS: Cholinergic stimulation of the detrusor induced by electrical field stimulation or exogenous application of carbachol or neostigmine evoked contractions consisting of a transient plus a tonic response, which was blocked by ML204, an inhibitor of TRPC4 channels.	Carbachol	117-126	transient receptor potential cation channel, subfamily C, member 4	Mus musculus	255-260
27983984-4	2016	We further showed that the AngII-induced cells showed significant contractile responses to carbachol.	Carbachol	91-100	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	27-32
27773818-3	2016	When SNU-407 cells were treated with the cholinergic agonist carbachol, eIF4B was phosphorylated in a dose- and time-dependent manner.	Carbachol	61-70	eukaryotic translation initiation factor 4B	Homo sapiens	72-77
27773818-4	2016	This carbachol effect was almost completely blocked by the muscarinic antagonist atropine, demonstrating that mAChRs specifically mediate the phosphorylation of eIF4B.	Carbachol	5-14	eukaryotic translation initiation factor 4B	Homo sapiens	161-166
27773818-5	2016	Carbachol-stimulated eIF4B phosphorylation was significantly reduced by the MEK1/2 inhibitor U0126, indicating that the MEK1/2-ERK1/2 pathway plays an important role in mAChR-mediated eIF4B phosphorylation.	Carbachol	0-9	eukaryotic translation initiation factor 4B	Homo sapiens	21-26
27773818-5	2016	Carbachol-stimulated eIF4B phosphorylation was significantly reduced by the MEK1/2 inhibitor U0126, indicating that the MEK1/2-ERK1/2 pathway plays an important role in mAChR-mediated eIF4B phosphorylation.	Carbachol	0-9	mitogen-activated protein kinase kinase 1	Homo sapiens	76-82
27773818-5	2016	Carbachol-stimulated eIF4B phosphorylation was significantly reduced by the MEK1/2 inhibitor U0126, indicating that the MEK1/2-ERK1/2 pathway plays an important role in mAChR-mediated eIF4B phosphorylation.	Carbachol	0-9	mitogen-activated protein kinase kinase 1	Homo sapiens	120-126
27773818-5	2016	Carbachol-stimulated eIF4B phosphorylation was significantly reduced by the MEK1/2 inhibitor U0126, indicating that the MEK1/2-ERK1/2 pathway plays an important role in mAChR-mediated eIF4B phosphorylation.	Carbachol	0-9	mitogen-activated protein kinase 3	Homo sapiens	127-133
27773818-5	2016	Carbachol-stimulated eIF4B phosphorylation was significantly reduced by the MEK1/2 inhibitor U0126, indicating that the MEK1/2-ERK1/2 pathway plays an important role in mAChR-mediated eIF4B phosphorylation.	Carbachol	0-9	eukaryotic translation initiation factor 4B	Homo sapiens	184-189
27625606-11	2016	CYN154806, the SST2 receptor antagonist, dose-dependently and significantly reversed the decreased acid response to CCh in M4 but not M3 KO mice.	Carbachol	116-119	somatostatin receptor 2	Mus musculus	15-19
27842583-9	2016	Results of urodynamic record of the TRPV1-/- mice during NS infusion showed reduced bladder pressure and contraction which exhibited decreased response to alpha, beta-me ATP, KCl, and carbachol and no response to CAP.	Carbachol	184-193	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	36-41
27543846-7	2016	However, catalase significantly reversed the DSS-induced reduction in baseline ion transport as well as colonic Isc responses to CCh.	Carbachol	129-132	catalase	Mus musculus	9-17
27301294-7	2016	CONCLUSION: It seems that antinociceptive effect of intra-LH administration of carbachol is mediated, at least partially, through the activation of orexin-1 and CB1 receptors in the vlPAG.	Carbachol	79-88	cannabinoid receptor 1	Rattus norvegicus	161-164
27301294-11	2016	CB1 receptor antagonist (AM251) microinjection in the vlPAG prevented carbachol-induced antinociception in a dose-dependent manner.	Carbachol	70-79	cannabinoid receptor 1	Rattus norvegicus	0-3
26895748-3	2016	In the present study, to examine the cholinergic signaling pathways responsible for the induction of a memory-related postsynaptic protein, a cholinergic agonist carbachol was used to induce the expression of activity-regulated cytoskeleton associated protein (Arc) in primary rat cortical neurons.	Carbachol	162-171	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	209-259
26969473-5	2016	CA inhibition suppressed the forskolin-induced decrease in pHi, while it allowed carbachol to consistently increase pHi by revealing that carbachol prominently activated NHE via Ca2+-calmodulin.	Carbachol	81-90	glucose-6-phosphate isomerase	Rattus norvegicus	116-119
26969473-5	2016	CA inhibition suppressed the forskolin-induced decrease in pHi, while it allowed carbachol to consistently increase pHi by revealing that carbachol prominently activated NHE via Ca2+-calmodulin.	Carbachol	138-147	glucose-6-phosphate isomerase	Rattus norvegicus	116-119
26969473-6	2016	Under NHE inhibition, forskolin and carbachol induced the remarkable decreases in pHi, which were slowed predominantly by CA inhibition and by CA or anion channel inhibition, respectively.	Carbachol	36-45	glucose-6-phosphate isomerase	Rattus norvegicus	82-85
26969473-7	2016	Our results suggest that forskolin and carbachol primarily activate the pHi-lowering CA and pHi-raising NHE, respectively, to regulate pHi for HCO3- secretion.	Carbachol	39-48	glucose-6-phosphate isomerase	Rattus norvegicus	72-75
26969473-7	2016	Our results suggest that forskolin and carbachol primarily activate the pHi-lowering CA and pHi-raising NHE, respectively, to regulate pHi for HCO3- secretion.	Carbachol	39-48	glucose-6-phosphate isomerase	Rattus norvegicus	92-95
26969473-7	2016	Our results suggest that forskolin and carbachol primarily activate the pHi-lowering CA and pHi-raising NHE, respectively, to regulate pHi for HCO3- secretion.	Carbachol	39-48	glucose-6-phosphate isomerase	Rattus norvegicus	92-95
27550942-12	2016	Increased carbachol-induced chloride secretion was seen in irinotecan-treated wild-type and Tlr4-/- mice at 24 hours (wild-type: 100.35 +- 18.37 muA/cm2; P = 0.022; Tlr4-/-: 102.72 +- 18.80 muA/cm2; P = 0.023).	Carbachol	10-19	toll-like receptor 4	Mus musculus	92-96
27550942-12	2016	Increased carbachol-induced chloride secretion was seen in irinotecan-treated wild-type and Tlr4-/- mice at 24 hours (wild-type: 100.35 +- 18.37 muA/cm2; P = 0.022; Tlr4-/-: 102.72 +- 18.80 muA/cm2; P = 0.023).	Carbachol	10-19	toll-like receptor 4	Mus musculus	165-169
27707967-8	2016	The necessity of neuronal dystroglycan for functional innervation by CCK-positive basket cell axon terminals was confirmed by reduced frequency of inhibitory events in pyramidal cells of dystroglycan-deficient mice and further corroborated by the inefficiency of carbachol to increase IPSC frequency in these cells.	Carbachol	263-272	cholecystokinin	Mus musculus	69-72
27567078-5	2016	Here we report that previously described ligand LM11A-24 shows significant inhibition of carbachol-induced persistent firing (PF) of entorhinal cortex (EC) pyramidal neurons in wild-type mice via selective interaction with p75(NTR).	Carbachol	89-98	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	223-226
27567078-5	2016	Here we report that previously described ligand LM11A-24 shows significant inhibition of carbachol-induced persistent firing (PF) of entorhinal cortex (EC) pyramidal neurons in wild-type mice via selective interaction with p75(NTR).	Carbachol	89-98	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	227-230
27474091-3	2016	EXPERIMENTAL APPROACH: The effects of the ACh receptor agonist carbachol (CCh) on IFN-beta-induced apoptosis of human SH-SY5Y neuroblastoma cells were examined by using western blots, immunofluorescence and cytofluorimetry.	Carbachol	63-72	interferon beta 1	Homo sapiens	82-90
27474091-3	2016	EXPERIMENTAL APPROACH: The effects of the ACh receptor agonist carbachol (CCh) on IFN-beta-induced apoptosis of human SH-SY5Y neuroblastoma cells were examined by using western blots, immunofluorescence and cytofluorimetry.	Carbachol	74-77	interferon beta 1	Homo sapiens	82-90
27474091-7	2016	KEY RESULTS: In SH-SY5Y cells, CCh inhibited IFN-beta-induced mitochondrial cytochrome c release, activation of caspases 9, 7 and 3, PARP cleavage and DNA fragmentation.	Carbachol	31-34	interferon beta 1	Homo sapiens	45-53
27474091-7	2016	KEY RESULTS: In SH-SY5Y cells, CCh inhibited IFN-beta-induced mitochondrial cytochrome c release, activation of caspases 9, 7 and 3, PARP cleavage and DNA fragmentation.	Carbachol	31-34	cytochrome c, somatic	Homo sapiens	76-88
27474091-7	2016	KEY RESULTS: In SH-SY5Y cells, CCh inhibited IFN-beta-induced mitochondrial cytochrome c release, activation of caspases 9, 7 and 3, PARP cleavage and DNA fragmentation.	Carbachol	31-34	caspase 9	Homo sapiens	112-131
27474091-7	2016	KEY RESULTS: In SH-SY5Y cells, CCh inhibited IFN-beta-induced mitochondrial cytochrome c release, activation of caspases 9, 7 and 3, PARP cleavage and DNA fragmentation.	Carbachol	31-34	collagen type XI alpha 2 chain	Homo sapiens	133-137
27474091-8	2016	The anti-apoptotic effect of CCh was mediated by M3 receptors, blocked by Gq/11 antagonist YM254890 and PKC inhibitor Go 6983, impaired by inhibition of ERK1/2 pathway, potentiated by overexpression of ERK2 and mimicked by ERK2-CA.	Carbachol	29-32	mitogen-activated protein kinase 3	Homo sapiens	153-159
27474091-8	2016	The anti-apoptotic effect of CCh was mediated by M3 receptors, blocked by Gq/11 antagonist YM254890 and PKC inhibitor Go 6983, impaired by inhibition of ERK1/2 pathway, potentiated by overexpression of ERK2 and mimicked by ERK2-CA.	Carbachol	29-32	mitogen-activated protein kinase 1	Homo sapiens	202-206
27474091-8	2016	The anti-apoptotic effect of CCh was mediated by M3 receptors, blocked by Gq/11 antagonist YM254890 and PKC inhibitor Go 6983, impaired by inhibition of ERK1/2 pathway, potentiated by overexpression of ERK2 and mimicked by ERK2-CA.	Carbachol	29-32	mitogen-activated protein kinase 1	Homo sapiens	223-227
27352269-8	2016	KEY RESULTS: Soluble inhibitors or PI3Kdelta knockdown reversed carbachol-induced constriction of human airways, relaxed agonist-contracted HASM and inhibited pAkt, pMYPT1 and pMLC in HASM.	Carbachol	64-73	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	35-44
27830759-5	2016	MCCV was increased by the cAMP-elevating agonists, forskolin or isoproterenol (10 muM) and by the Ca2+-elevating agonist, carbachol (0.3 muM).	Carbachol	122-131	latexin	Homo sapiens	137-140
27830759-8	2016	MCC velocity was most dramatically accelerated by the synergistic combination of forskolin and carbachol, which produced near-maximal clearance rates regardless of prior treatment with CFTR or ENaC inhibitors.	Carbachol	95-104	CF transmembrane conductance regulator	Homo sapiens	185-189
27474091-9	2016	Blockade of JNK activation enhanced the CCh anti-apoptotic response.	Carbachol	40-43	mitogen-activated protein kinase 8	Homo sapiens	12-15
27474091-10	2016	IFN-beta inhibited JNK activation and up-regulated CCh-induced ERK1/2 signalling.	Carbachol	51-54	interferon beta 1	Homo sapiens	0-8
27474091-10	2016	IFN-beta inhibited JNK activation and up-regulated CCh-induced ERK1/2 signalling.	Carbachol	51-54	mitogen-activated protein kinase 3	Homo sapiens	63-69
27625606-12	2016	Octreotide, the somatostatin analog, inhibited the secretion of acid under CCh-stimulated conditions in WT mice.	Carbachol	75-78	somatostatin	Mus musculus	16-28
27509878-7	2016	In the functional studies, the urothelium removal from human bladder strips leads to an increase in carbachol-induced contraction that is mimicked by CBS inhibition.	Carbachol	100-109	cystathionine beta-synthase	Homo sapiens	150-153
27509878-9	2016	The increase in H2S production and in turn of cGMP is driven by CBS-cGMP/PKG-dependent phosphorylation at Ser(227) following carbachol stimulation.	Carbachol	125-134	cystathionine beta-synthase	Homo sapiens	64-67
27509878-9	2016	The increase in H2S production and in turn of cGMP is driven by CBS-cGMP/PKG-dependent phosphorylation at Ser(227) following carbachol stimulation.	Carbachol	125-134	protein kinase cGMP-dependent 1	Homo sapiens	73-76
26909644-7	2016	P20 peptide caused dose-dependent relaxation of carbachol-precontracted ASM and blocked carbachol-induced contraction.	Carbachol	48-57	tubulin polymerization promoting protein family member 3	Homo sapiens	0-3
26909644-7	2016	P20 peptide caused dose-dependent relaxation of carbachol-precontracted ASM and blocked carbachol-induced contraction.	Carbachol	88-97	tubulin polymerization promoting protein family member 3	Homo sapiens	0-3
26871404-0	2016	Role of orexin-2 receptors in the nucleus accumbens in antinociception induced by carbachol stimulation of the lateral hypothalamus in formalin test.	Carbachol	82-91	hypocretin neuropeptide precursor	Homo sapiens	8-14
26871404-7	2016	The findings showed that TCS OX2 29 administration dose dependently blocked carbachol-induced antinociception during both phases of formalin-induced pain.	Carbachol	76-85	CD200 molecule	Homo sapiens	29-32
27320188-9	2016	H2O2 -induced dilatation, which occurred only at concentrations &gt;=100microM, was reduced by a blocking antibody to TRPM2, which had no effect on carbachol-induced responses.	Carbachol	148-157	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	118-123
27283411-11	2016	In HEK293T cells coexpressing TREK-2 and type 3 muscarinic receptor, application of carbachol induced transient activation and sustained suppression of ITREK-2,w-c and cell-attached ITREK-2.	Carbachol	84-93	potassium channel, subfamily K, member 10	Mus musculus	30-36
27118568-0	2016	Carbachol-induced signaling through Thr696-phosphorylation of myosin phosphatase-targeting subunit 1 (MYPT1) in rat bladder smooth muscle cells.	Carbachol	0-9	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	62-100
27118568-0	2016	Carbachol-induced signaling through Thr696-phosphorylation of myosin phosphatase-targeting subunit 1 (MYPT1) in rat bladder smooth muscle cells.	Carbachol	0-9	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	102-107
27118568-3	2016	We attempt to directly observe the quantitative protein expression of Rho A/ROCK and phosphorylation of MYPT1 at Thr696 after carbachol administration in rat bladder smooth muscle cells (RBMSCs).	Carbachol	126-135	ras homolog family member A	Rattus norvegicus	70-75
27118568-3	2016	We attempt to directly observe the quantitative protein expression of Rho A/ROCK and phosphorylation of MYPT1 at Thr696 after carbachol administration in rat bladder smooth muscle cells (RBMSCs).	Carbachol	126-135	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	104-109
27118568-5	2016	The effects of both concentration and time-course induced by the muscarinic agonist carbachol were investigated by assessing the expression of Rho A/ROCK and MYPT1 phosphorylation at Thr696 using Western blot.	Carbachol	84-93	ras homolog family member A	Rattus norvegicus	143-148
27118568-5	2016	The effects of both concentration and time-course induced by the muscarinic agonist carbachol were investigated by assessing the expression of Rho A/ROCK and MYPT1 phosphorylation at Thr696 using Western blot.	Carbachol	84-93	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	158-163
27118568-6	2016	RESULTS: In the dose-course studies, carbachol showed significant increase in phosphorylation of MYPT1 at Thr696 (p-MYPT1) from concentrations of 15-100 muM based on Western blot results (p &lt; 0.05, ANOVA test).	Carbachol	37-46	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	97-102
27118568-6	2016	RESULTS: In the dose-course studies, carbachol showed significant increase in phosphorylation of MYPT1 at Thr696 (p-MYPT1) from concentrations of 15-100 muM based on Western blot results (p &lt; 0.05, ANOVA test).	Carbachol	37-46	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	116-121
27118568-7	2016	In the time-course studies, treatment of cells with 15 muM of carbachol significantly enhanced the expression of p-MYPT1 from 3 to 15 h (p &lt; 0.05, ANOVA test) and induced the expression of Rho A from 10 to 120 min (p &lt; 0.05, ANOVA test).	Carbachol	62-71	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	115-120
27118568-7	2016	In the time-course studies, treatment of cells with 15 muM of carbachol significantly enhanced the expression of p-MYPT1 from 3 to 15 h (p &lt; 0.05, ANOVA test) and induced the expression of Rho A from 10 to 120 min (p &lt; 0.05, ANOVA test).	Carbachol	62-71	ras homolog family member A	Rattus norvegicus	192-197
27118568-8	2016	CONCLUSIONS: Carbachol can induce the expression of ROCK pathway, leading to MYPT1 phosphorylation at Thr696 and thereby sustained RBSMCs contraction.	Carbachol	13-22	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	77-82
27084847-5	2016	TLR7 agonists were added to guinea pig airways following precontraction with carbachol in vitro or histamine in vivo.	Carbachol	77-86	toll-like receptor 7	Cavia porcellus	0-4
27226533-9	2016	The muscarinic agonist carbachol induced pronounced transient PKCbetaI translocation and sustained recruitment of PKCepsilon.	Carbachol	23-32	protein kinase C, epsilon	Mus musculus	114-124
27226533-10	2016	When rise of [Ca(2+)]pm was prevented, the carbachol-induced DAG and PKCepsilon responses were somewhat reduced, but PKCbetaI translocation was completely abolished.	Carbachol	43-52	protein kinase C, epsilon	Mus musculus	69-79
26847850-2	2016	MYPT1 showed significant constitutive T696 and T853 phosphorylation, which is predicted to inhibit MLCP activity in isolated ileal smooth muscle tissues, with additional phosphorylation upon pharmacological treatment with the muscarinic agonist carbachol.	Carbachol	245-254	protein phosphatase 1, regulatory subunit 12A	Mus musculus	0-5
26847850-8	2016	Isolated MYPT1-deficient tissues from MYPT1(SM-/-) mice contracted and relaxed rapidly with moderate differences in sustained responses to KCl and carbachol treatments and washouts, respectively.	Carbachol	147-156	protein phosphatase 1, regulatory subunit 12A	Mus musculus	9-14
26752781-3	2016	The anti-fibrillatory action of carbamylcholine was prevented by the nicotinic receptor antagonist mecamylamine, inhibitors of neuronal nitric oxide synthase (nNOS) and soluble guanylyl cyclase (sGC), and can be mimicked by the nitric oxide (NO) donor sodium nitroprusside.	Carbachol	32-47	nitric oxide synthase 1	Homo sapiens	127-157
26752781-3	2016	The anti-fibrillatory action of carbamylcholine was prevented by the nicotinic receptor antagonist mecamylamine, inhibitors of neuronal nitric oxide synthase (nNOS) and soluble guanylyl cyclase (sGC), and can be mimicked by the nitric oxide (NO) donor sodium nitroprusside.	Carbachol	32-47	nitric oxide synthase 1	Homo sapiens	159-163
26752781-6	2016	These data demonstrate a protective effect of carbamylcholine on VFT that depends upon both muscarinic and nicotinic receptor stimulation, where the generation of NO is likely to be via a neuronal nNOS-sGC dependent pathway.	Carbachol	46-61	nitric oxide synthase 1	Homo sapiens	197-201
26752781-17	2016	These data demonstrate a protective effect of CCh on VFT that depends upon both muscarinic and nicotinic receptor stimulation, where the generation of NO is likely to be via a neuronal nNOS/sGC-dependent pathway.	Carbachol	46-49	nitric oxide synthase 1	Homo sapiens	185-189
27282572-4	2016	Adding carbachol which is a cholinergic agonist to the ATRA treatment resulted in an increase of a granulocytic differentiation marker (CD11b) as compared with ATRA treatment alone (p&lt;0.05), indicating that cholinergic activation enhanced ATRA in inducing NB-4 maturation.	Carbachol	7-16	integrin subunit alpha M	Homo sapiens	136-141
26966862-9	2016	The initial rates of CCh-stimulated cell volume reduction in acinar cells from hAQP1-expressing glands post IR were similar to those from control cells.	Carbachol	21-24	aquaporin 1 (Colton blood group)	Homo sapiens	79-84
27076615-7	2016	The reliance of CTSS secretion on Rab27 activity was supported by in vitro findings that newly synthesized CTSS was detected in and secreted from Rab27-enriched secretory vesicles and that expression of dominant negative Rab27b reduced carbachol-stimulated secretion of CTSS in cultured LGAC.	Carbachol	236-245	cathepsin S	Mus musculus	16-20
27076615-7	2016	The reliance of CTSS secretion on Rab27 activity was supported by in vitro findings that newly synthesized CTSS was detected in and secreted from Rab27-enriched secretory vesicles and that expression of dominant negative Rab27b reduced carbachol-stimulated secretion of CTSS in cultured LGAC.	Carbachol	236-245	RAB27A, member RAS oncogene family	Homo sapiens	34-39
27076615-7	2016	The reliance of CTSS secretion on Rab27 activity was supported by in vitro findings that newly synthesized CTSS was detected in and secreted from Rab27-enriched secretory vesicles and that expression of dominant negative Rab27b reduced carbachol-stimulated secretion of CTSS in cultured LGAC.	Carbachol	236-245	cathepsin S	Mus musculus	107-111
27076615-7	2016	The reliance of CTSS secretion on Rab27 activity was supported by in vitro findings that newly synthesized CTSS was detected in and secreted from Rab27-enriched secretory vesicles and that expression of dominant negative Rab27b reduced carbachol-stimulated secretion of CTSS in cultured LGAC.	Carbachol	236-245	RAB27B, member RAS oncogene family	Mus musculus	221-227
27076615-7	2016	The reliance of CTSS secretion on Rab27 activity was supported by in vitro findings that newly synthesized CTSS was detected in and secreted from Rab27-enriched secretory vesicles and that expression of dominant negative Rab27b reduced carbachol-stimulated secretion of CTSS in cultured LGAC.	Carbachol	236-245	cathepsin S	Mus musculus	107-111
26879866-9	2016	Plasma vasopressin levels evaluated by ELISA kit assay increased after carbachol into the 4th V. Intravenous blockade of V1 receptors prior to carbachol into the 4thV abolished the increase in IP evoked by carbachol.	Carbachol	71-80	arginine vasopressin	Rattus norvegicus	7-18
26911851-7	2016	The stimulatory effect of 8MM-IBMX on TBKCs was reversed upon activation of muscarinic acetylcholine receptors with carbachol (1 muM).	Carbachol	116-125	latexin	Homo sapiens	129-132
26879866-9	2016	Plasma vasopressin levels evaluated by ELISA kit assay increased after carbachol into the 4th V. Intravenous blockade of V1 receptors prior to carbachol into the 4thV abolished the increase in IP evoked by carbachol.	Carbachol	143-152	arginine vasopressin	Rattus norvegicus	7-18
26879866-9	2016	Plasma vasopressin levels evaluated by ELISA kit assay increased after carbachol into the 4th V. Intravenous blockade of V1 receptors prior to carbachol into the 4thV abolished the increase in IP evoked by carbachol.	Carbachol	143-152	arginine vasopressin	Rattus norvegicus	7-18
26879866-10	2016	Therefore, our findings suggest that cholinergic activation of neurons in the medulla oblongata by carbachol injections into the 4thV increases IP due to plasma vasopressin release, which acts in V1 receptors in the UB.	Carbachol	99-108	arginine vasopressin	Rattus norvegicus	161-172
26661936-10	2016	The GPER agonist G-1 caused a concentration-dependent inhibition of carbachol -induced circular muscle strips contraction, which was abolished by tetrodotoxin and the neuronal nitric oxide synthase (nNOS) inhibitor N-propyl-l-arginine.	Carbachol	68-77	G protein-coupled estrogen receptor 1	Mus musculus	4-8
26961238-3	2016	Loss of Rgs5 provoked dramatically exaggerated bradycardia and significantly (P&lt;0.05) prolonged sinus nodal recovery time in response to carbachol (0.1 mg/kg, intraperitoneally).	Carbachol	140-149	regulator of G-protein signaling 5	Mus musculus	8-12
26956674-11	2016	Carbachol-induced ASM cell migration was reduced by selective inhibitors of PI3K/Akt (LY294002) and p38 (SB203580), suggesting that it occurred through p38 and Akt phosphorylation, which was inhibited by the M3 mAChR antagonist 4-DAMP.	Carbachol	0-9	AKT serine/threonine kinase 1	Homo sapiens	81-84
26956674-11	2016	Carbachol-induced ASM cell migration was reduced by selective inhibitors of PI3K/Akt (LY294002) and p38 (SB203580), suggesting that it occurred through p38 and Akt phosphorylation, which was inhibited by the M3 mAChR antagonist 4-DAMP.	Carbachol	0-9	mitogen-activated protein kinase 14	Homo sapiens	100-103
26956674-11	2016	Carbachol-induced ASM cell migration was reduced by selective inhibitors of PI3K/Akt (LY294002) and p38 (SB203580), suggesting that it occurred through p38 and Akt phosphorylation, which was inhibited by the M3 mAChR antagonist 4-DAMP.	Carbachol	0-9	mitogen-activated protein kinase 14	Homo sapiens	152-155
26956674-11	2016	Carbachol-induced ASM cell migration was reduced by selective inhibitors of PI3K/Akt (LY294002) and p38 (SB203580), suggesting that it occurred through p38 and Akt phosphorylation, which was inhibited by the M3 mAChR antagonist 4-DAMP.	Carbachol	0-9	AKT serine/threonine kinase 1	Homo sapiens	160-163
25523105-4	2016	Microglia cultured from adult and neonatal brain contained a carbachol-sensitive subpopulation (8 and 9 %), which was increased by treatment with interferon-gamma to around 60 %.	Carbachol	61-70	interferon gamma	Mus musculus	146-162
26660312-5	2016	When TRPP2 protein was knocked down in gallbladder muscle strips from guinea pig, carbachol (CCh)-evoked Ca(2+) release and extracellular Ca(2+) influx were reduced significantly, and gallbladder contractions induced by endothelin 1 and cholecystokinin were suppressed markedly as well.	Carbachol	93-96	endothelin-1	Cavia porcellus	220-232
26661936-10	2016	The GPER agonist G-1 caused a concentration-dependent inhibition of carbachol -induced circular muscle strips contraction, which was abolished by tetrodotoxin and the neuronal nitric oxide synthase (nNOS) inhibitor N-propyl-l-arginine.	Carbachol	68-77	nitric oxide synthase 1, neuronal	Mus musculus	167-197
26661936-10	2016	The GPER agonist G-1 caused a concentration-dependent inhibition of carbachol -induced circular muscle strips contraction, which was abolished by tetrodotoxin and the neuronal nitric oxide synthase (nNOS) inhibitor N-propyl-l-arginine.	Carbachol	68-77	nitric oxide synthase 1, neuronal	Mus musculus	199-203
27555117-4	2016	The bradycardia following the microinjection of CCh into the PHN can be attenuated by the previous administration of the vasopressin V1 receptor antagonist [d(CH2 )5 Tyr(Me)] arginine vasopressin (AVPX).	Carbachol	48-51	arginine vasopressin	Rattus norvegicus	121-132
26656315-6	2016	KEY FINDINGS: Our study observed the protective effect of carbachol postconditioning on H/R-induced injury in human gastric epithelial cell lines (hGES-1) cells, which is achieved by direct activation of vanilloid receptor subtype 1 (VR1) and production of calcitonin gene-related peptide (CGRP), and in the inhibition of cell apoptosis.	Carbachol	58-67	transient receptor potential cation channel subfamily V member 1	Homo sapiens	204-232
26656315-6	2016	KEY FINDINGS: Our study observed the protective effect of carbachol postconditioning on H/R-induced injury in human gastric epithelial cell lines (hGES-1) cells, which is achieved by direct activation of vanilloid receptor subtype 1 (VR1) and production of calcitonin gene-related peptide (CGRP), and in the inhibition of cell apoptosis.	Carbachol	58-67	transient receptor potential cation channel subfamily V member 1	Homo sapiens	234-237
26656315-6	2016	KEY FINDINGS: Our study observed the protective effect of carbachol postconditioning on H/R-induced injury in human gastric epithelial cell lines (hGES-1) cells, which is achieved by direct activation of vanilloid receptor subtype 1 (VR1) and production of calcitonin gene-related peptide (CGRP), and in the inhibition of cell apoptosis.	Carbachol	58-67	calcitonin related polypeptide alpha	Homo sapiens	257-288
26656315-6	2016	KEY FINDINGS: Our study observed the protective effect of carbachol postconditioning on H/R-induced injury in human gastric epithelial cell lines (hGES-1) cells, which is achieved by direct activation of vanilloid receptor subtype 1 (VR1) and production of calcitonin gene-related peptide (CGRP), and in the inhibition of cell apoptosis.	Carbachol	58-67	calcitonin related polypeptide alpha	Homo sapiens	290-294
25520285-4	2016	Functionally, the contractile embryoid bodies (EBs) displayed calcium cycling and were responsive to the chronotropic agents isoprenaline (0.1 muM) and carbachol (1 muM).	Carbachol	152-161	latexin	Homo sapiens	165-168
27555117-4	2016	The bradycardia following the microinjection of CCh into the PHN can be attenuated by the previous administration of the vasopressin V1 receptor antagonist [d(CH2 )5 Tyr(Me)] arginine vasopressin (AVPX).	Carbachol	48-51	arginine vasopressin	Rattus norvegicus	184-195
27555117-6	2016	The attenuation by AVPX of the bradycardia that results following the high doses of CCh suggests that AVP is released into the circulation following stimulation of cholinergic systems within the PHN.	Carbachol	84-87	arginine vasopressin	Rattus norvegicus	19-22
27555117-7	2016	Thus, microinjection of a high dose of CCh (11 nmol) into the PHN alters the sensitivity of the baroreceptor reflex by increasing peripheral levels of AVP.	Carbachol	39-42	arginine vasopressin	Rattus norvegicus	151-154
26606130-3	2016	AF710B exhibits an allosteric agonistic profile on the M1 muscarinic receptor; very low concentrations of AF710B significantly potentiated the binding and efficacy of carbachol on M1 receptors and their downstream effects (p-ERK1/2, p-CREB).	Carbachol	167-176	mitogen activated protein kinase 3	Rattus norvegicus	225-231
26129651-6	2016	IFN-gamma itself increased [Ca(2+)](i) in rat and human goblet cells and prevented the increase in [Ca(2+)](i) caused by carbachol.	Carbachol	121-130	interferon gamma	Rattus norvegicus	0-9
26129651-7	2016	Carbachol prevented IFN-gamma-mediated increase in [Ca(2+)](i).	Carbachol	0-9	interferon gamma	Homo sapiens	20-29
26129651-9	2016	IFN-gamma blocked carbachol-induced high molecular weight glycoconjugate secretion and reduced goblet cell proliferation.	Carbachol	18-27	interferon gamma	Homo sapiens	0-9
26606130-3	2016	AF710B exhibits an allosteric agonistic profile on the M1 muscarinic receptor; very low concentrations of AF710B significantly potentiated the binding and efficacy of carbachol on M1 receptors and their downstream effects (p-ERK1/2, p-CREB).	Carbachol	167-176	cAMP responsive element binding protein 1	Rattus norvegicus	235-239
25919006-7	2015	Individually, IL-17A and IL-25 enhanced contractility of human bronchial smooth muscle induced by methacholine or carbachol.	Carbachol	114-123	interleukin 17A	Homo sapiens	14-20
25919006-7	2015	Individually, IL-17A and IL-25 enhanced contractility of human bronchial smooth muscle induced by methacholine or carbachol.	Carbachol	114-123	interleukin 25	Homo sapiens	25-30
26344105-5	2015	This carbachol-induced inhibitory effect on Ca(2+) oscillations in myocytes and pericytes was reversed by ODQ, an inhibitor of soluble guanylyl cyclase (sGC) and by Rp-8-pCPT-cGMPS, an inhibitor of protein kinase G (PKG).	Carbachol	5-14	protein kinase cGMP-dependent 1	Homo sapiens	198-214
26344105-5	2015	This carbachol-induced inhibitory effect on Ca(2+) oscillations in myocytes and pericytes was reversed by ODQ, an inhibitor of soluble guanylyl cyclase (sGC) and by Rp-8-pCPT-cGMPS, an inhibitor of protein kinase G (PKG).	Carbachol	5-14	protein kinase cGMP-dependent 1	Homo sapiens	216-219
26494513-9	2015	The findings of this study showed that the OX2 receptor has a critical role in modulating reward circuit in the VTA and NAc, when the LH was stimulated by carbachol.	Carbachol	155-164	CD200 receptor 1	Rattus norvegicus	43-55
26546746-4	2015	TGF-beta1+carbachol enhanced the generation of mesenchymal cells, which was significantly reduced by aclidinium bromide or formoterol.	Carbachol	10-19	transforming growth factor beta 1	Homo sapiens	0-9
26648844-6	2015	Inhibition of the principal eCB CB1 receptor blocked carbachol induced LTD in both rats and mice.	Carbachol	53-62	cannabinoid receptor 1	Rattus norvegicus	32-35
26648844-7	2015	Furthermore, when challenged with a sub-threshold carbachol application, LTD was induced in slices pretreated with the monoacylglycerol lipase (MAGL) inhibitor JZL184, suggesting that the eCB 2-arachidonylglyerol (2-AG) mediates M1 mAChR LTD.	Carbachol	50-59	monoglyceride lipase	Rattus norvegicus	119-142
26648844-7	2015	Furthermore, when challenged with a sub-threshold carbachol application, LTD was induced in slices pretreated with the monoacylglycerol lipase (MAGL) inhibitor JZL184, suggesting that the eCB 2-arachidonylglyerol (2-AG) mediates M1 mAChR LTD.	Carbachol	50-59	monoglyceride lipase	Rattus norvegicus	144-148
26546746-7	2015	In mesenchymal cells, TGF-beta1+carbachol induced the deposition of collagen-I and fibronectin which was prevented by both drugs dose-dependently.	Carbachol	32-41	fibronectin 1	Homo sapiens	83-94
26294392-8	2015	CCh and BK increased phosphorylation of MYPT-1 and MLC20 and auto-phosphorylation of SrcFK and FAK.	Carbachol	0-3	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	40-46
26909310-6	2015	RESULTS: Deletion of ABHD6 potentiated insulin secretion in response to the fuels glutamine plus leucine and alpha-ketoisocaproate and to the non-fuel stimuli glucagon-like peptide 1, carbamylcholine and elevated KCl.	Carbachol	184-199	abhydrolase domain containing 6	Mus musculus	21-26
25979836-5	2015	PAK2 was activated by some pancreatic growth-factors [EGF, PDGF, bFGF], by secretagogues activating phospholipase-C (PLC) [CCK, carbachol, bombesin] and by post-receptor stimulants activating PKC [TPA], but not agents only mobilizing cellular calcium or increasing cyclic AMP.	Carbachol	128-137	p21 (RAC1) activated kinase 2	Rattus norvegicus	0-4
25812766-8	2015	In this paper, we investigated the ability of a combination of the cytotoxic drug paclitaxel plus carbachol, a cholinergic agonist, at low doses, to induce death in breast tumor MCF-7 cells, via mAChR activation, and the role of nitric oxide synthase (NOS) and arginase in this effect.	Carbachol	98-107	nitric oxide synthase 1	Homo sapiens	229-250
26051129-6	2015	All subtypes of prostaglandin E2 (PGE2) receptors (EP1-EP4) were expressed in ileum, and PGE2 and selective EP2 or EP4 agonist inhibited CCh-mediated contraction.	Carbachol	137-140	prostaglandin E receptor 1	Rattus norvegicus	51-58
26051129-6	2015	All subtypes of prostaglandin E2 (PGE2) receptors (EP1-EP4) were expressed in ileum, and PGE2 and selective EP2 or EP4 agonist inhibited CCh-mediated contraction.	Carbachol	137-140	prostaglandin E receptor 2	Rattus norvegicus	108-111
26051129-6	2015	All subtypes of prostaglandin E2 (PGE2) receptors (EP1-EP4) were expressed in ileum, and PGE2 and selective EP2 or EP4 agonist inhibited CCh-mediated contraction.	Carbachol	137-140	prostaglandin E receptor 4	Rattus norvegicus	55-58
26051129-9	2015	Finally, in ileal tissues isolated from peritonitis model rat, iNOS expression was upregulated only at 4 hr after LPS administration, resulting in enhanced inhibitory action of LPS against CCh-induced contraction.	Carbachol	189-192	nitric oxide synthase 2	Rattus norvegicus	63-67
26051129-11	2015	Moreover, in late phase of LPS treatment, iNOS is expressed to produce NO, which in turn inhibited the contraction by CCh.	Carbachol	118-121	nitric oxide synthase 2	Rattus norvegicus	42-46
26071486-7	2015	Overexpression of CHRM3 or activation of CHRM3 by carbachol promoted cell proliferation, migration, and castration resistance.	Carbachol	50-59	cholinergic receptor muscarinic 3	Homo sapiens	41-46
26355753-4	2015	Addition of the full agonist carbamoylcholine activated and opened the nAChR ion channel, as revealed by the increase in capacitance relative to that of the nAChR-thiolipid system under basal conditions.	Carbachol	29-45	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	71-76
26355753-4	2015	Addition of the full agonist carbamoylcholine activated and opened the nAChR ion channel, as revealed by the increase in capacitance relative to that of the nAChR-thiolipid system under basal conditions.	Carbachol	29-45	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	157-162
26378782-9	2015	Histamine/carbachol stimulated gastric acid secretion was significantly reduced (range 84-95%, P&lt;0.005) in ClC-2-/- compared to WT, while pepsinogen secretion was unaffected.	Carbachol	10-19	chloride channel, voltage-sensitive 2	Mus musculus	110-115
26365984-6	2015	Similar decreases in IP3R and carbachol (CCh)-stimulated [Ca(2+)]i elevation were detected in acinar cells from lymphotoxin-alpha (LTalpha) transgenic (TG) mice, a model for (SS).	Carbachol	30-39	lymphotoxin A	Mus musculus	112-129
26365984-6	2015	Similar decreases in IP3R and carbachol (CCh)-stimulated [Ca(2+)]i elevation were detected in acinar cells from lymphotoxin-alpha (LTalpha) transgenic (TG) mice, a model for (SS).	Carbachol	30-39	lymphotoxin A	Mus musculus	131-138
26365984-6	2015	Similar decreases in IP3R and carbachol (CCh)-stimulated [Ca(2+)]i elevation were detected in acinar cells from lymphotoxin-alpha (LTalpha) transgenic (TG) mice, a model for (SS).	Carbachol	41-44	lymphotoxin A	Mus musculus	112-129
26365984-6	2015	Similar decreases in IP3R and carbachol (CCh)-stimulated [Ca(2+)]i elevation were detected in acinar cells from lymphotoxin-alpha (LTalpha) transgenic (TG) mice, a model for (SS).	Carbachol	41-44	lymphotoxin A	Mus musculus	131-138
26215661-9	2015	The effect of carbachol (100 muM) and isoproterenol (4 mug mL(-1)) on single cells and groups of cells was demonstrated and the feature for immunostaining (beta-actin) applicability of the chip was revealed.	Carbachol	14-23	actin, beta	Rattus norvegicus	156-166
26294392-8	2015	CCh and BK increased phosphorylation of MYPT-1 and MLC20 and auto-phosphorylation of SrcFK and FAK.	Carbachol	0-3	myosin light chain 12B	Homo sapiens	51-56
26294392-8	2015	CCh and BK increased phosphorylation of MYPT-1 and MLC20 and auto-phosphorylation of SrcFK and FAK.	Carbachol	0-3	protein tyrosine kinase 2	Homo sapiens	95-98
26229434-7	2015	On the contrary, carbachol could enhance the phosphorylation level of Nedd4-2 as an alternative to SGK1, and thus rescue the ubiquitin-mediated degradation of hERG channels caused by probucol.	Carbachol	17-26	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	70-77
26358343-5	2015	RESULTS: Carbachol-stimulated secretion rates were the following: controls, 1670 +- 381 pl min(-1) gland(-1); CRS, 965 +- 440 pl min(-1) gland(-1); and CF, 933 +- 588 pl min(-1) gland(-1) (p = 0.23, Kruskal-Wallis test).	Carbachol	9-18	CD59 molecule (CD59 blood group)	Homo sapiens	91-97
26358343-5	2015	RESULTS: Carbachol-stimulated secretion rates were the following: controls, 1670 +- 381 pl min(-1) gland(-1); CRS, 965 +- 440 pl min(-1) gland(-1); and CF, 933 +- 588 pl min(-1) gland(-1) (p = 0.23, Kruskal-Wallis test).	Carbachol	9-18	CD59 molecule (CD59 blood group)	Homo sapiens	129-135
26358343-5	2015	RESULTS: Carbachol-stimulated secretion rates were the following: controls, 1670 +- 381 pl min(-1) gland(-1); CRS, 965 +- 440 pl min(-1) gland(-1); and CF, 933 +- 588 pl min(-1) gland(-1) (p = 0.23, Kruskal-Wallis test).	Carbachol	9-18	CD59 molecule (CD59 blood group)	Homo sapiens	129-135
26169369-8	2015	Moreover, the activating phosphorylation and Golgi translocation of endothelial NO synthase in response to the M3R agonist carbachol were diminished.	Carbachol	123-132	cholinergic receptor, muscarinic 3, cardiac	Mus musculus	111-114
26258553-8	2015	Pre-contracted telokin-/- gastric fundus smooth muscles have increased contractile responses to KCl, CCh, or cholinergic neurotransmission and reduced relaxation to 8-Bromo-cGMP, SNP, and nitrergic neurotransmission.	Carbachol	101-104	myosin, light polypeptide kinase	Mus musculus	15-22
26405813-6	2015	RESULTS: Treatment of small intestinal tissue with clotrimazole inhibited the Cl- secretory currents that resulted from challenge with the cAMP-agonist vasoactive intestinal peptide (VIP) or Ca(2+)-agonist carbachol in a dose-dependent fashion.	Carbachol	206-215	vasoactive intestinal peptide	Homo sapiens	183-186
25934671-11	2015	Nitrofen-treated lungs exhibited an increased number of proliferating Sox9-positive distal epithelial progenitor cells, which were decreased and normalized by treatment with carbachol.	Carbachol	174-183	SRY-box transcription factor 9	Homo sapiens	70-74
26229434-7	2015	On the contrary, carbachol could enhance the phosphorylation level of Nedd4-2 as an alternative to SGK1, and thus rescue the ubiquitin-mediated degradation of hERG channels caused by probucol.	Carbachol	17-26	ETS transcription factor ERG	Homo sapiens	159-163
26021821-8	2015	In addition, the glucagon-mediated impairment of carbachol-induced contraction was prevented by either removing epithelial cells or blocking NOS (L-NAME), COX (indomethacin) or COX-1 (SC-560).	Carbachol	49-58	cytochrome c oxidase I, mitochondrial	Mus musculus	177-182
25956403-10	2015	In the presence of carbachol, both beta-AR agonists increased MLC phosphorylation, an effect reduced by Y27,632 only in the presence of 1 muM carbachol.	Carbachol	19-28	modulator of VRAC current 1	Homo sapiens	62-65
25956403-10	2015	In the presence of carbachol, both beta-AR agonists increased MLC phosphorylation, an effect reduced by Y27,632 only in the presence of 1 muM carbachol.	Carbachol	142-151	latexin	Homo sapiens	138-141
25703905-4	2015	Functional studies in the presence of muscarinic receptor and nitric oxide synthase (NOS) antagonists revealed that in M3 receptor-mediated carbachol secretion, nitric oxide, deriving mainly from neuronal NOS (nNOS) in control, and iNOS in diabetic rabbits, was involved.	Carbachol	140-149	nitric oxide synthase, brain	Oryctolagus cuniculus	62-83
25703905-4	2015	Functional studies in the presence of muscarinic receptor and nitric oxide synthase (NOS) antagonists revealed that in M3 receptor-mediated carbachol secretion, nitric oxide, deriving mainly from neuronal NOS (nNOS) in control, and iNOS in diabetic rabbits, was involved.	Carbachol	140-149	nitric oxide synthase, brain	Oryctolagus cuniculus	196-208
25703905-4	2015	Functional studies in the presence of muscarinic receptor and nitric oxide synthase (NOS) antagonists revealed that in M3 receptor-mediated carbachol secretion, nitric oxide, deriving mainly from neuronal NOS (nNOS) in control, and iNOS in diabetic rabbits, was involved.	Carbachol	140-149	nitric oxide synthase, brain	Oryctolagus cuniculus	210-214
25703905-4	2015	Functional studies in the presence of muscarinic receptor and nitric oxide synthase (NOS) antagonists revealed that in M3 receptor-mediated carbachol secretion, nitric oxide, deriving mainly from neuronal NOS (nNOS) in control, and iNOS in diabetic rabbits, was involved.	Carbachol	140-149	nitric oxide synthase, inducible	Oryctolagus cuniculus	232-236
25139191-0	2015	Carbachol-induced colonic mucus formation requires transport via NKCC1, K+ channels and CFTR.	Carbachol	0-9	solute carrier family 12, member 2	Mus musculus	65-70
25139191-0	2015	Carbachol-induced colonic mucus formation requires transport via NKCC1, K+ channels and CFTR.	Carbachol	0-9	cystic fibrosis transmembrane conductance regulator	Mus musculus	88-92
25139191-7	2015	The results showed that the carbachol-induced increase in membrane current was dependent on NKCC1 co-transport, basolateral K(+) channels and Cftr activity.	Carbachol	28-37	solute carrier family 12, member 2	Mus musculus	92-97
25139191-7	2015	The results showed that the carbachol-induced increase in membrane current was dependent on NKCC1 co-transport, basolateral K(+) channels and Cftr activity.	Carbachol	28-37	cystic fibrosis transmembrane conductance regulator	Mus musculus	142-146
25139191-8	2015	In contrast, the carbachol-induced increase in capacitance was partially dependent on NKCC1 and K(+) channel activity, but did not require Cftr activity.	Carbachol	17-26	solute carrier family 12, member 2	Mus musculus	86-91
25139191-9	2015	Carbachol also induced an increase in mucus thickness that was inhibited by the NKCC1 blocker bumetanide.	Carbachol	0-9	solute carrier family 12, member 2	Mus musculus	80-85
25139191-10	2015	However, mice that lacked a functional Cftr channel did not respond to carbachol with an increase in mucus thickness, suggesting that carbachol-induced mucin expansion requires Cftr channel activity.	Carbachol	134-143	cystic fibrosis transmembrane conductance regulator	Mus musculus	39-43
25139191-10	2015	However, mice that lacked a functional Cftr channel did not respond to carbachol with an increase in mucus thickness, suggesting that carbachol-induced mucin expansion requires Cftr channel activity.	Carbachol	134-143	cystic fibrosis transmembrane conductance regulator	Mus musculus	177-181
25948584-4	2015	Carbachol induced downregulation and redistribution of claudin-4, but not occludin or ZO-1 (also known as TJP1).	Carbachol	0-9	claudin 4	Rattus norvegicus	55-64
25948584-5	2015	Small hairpin RNA (shRNA)-mediated claudin-4 knockdown suppressed, whereas claudin-4 overexpression retained, the TER response to carbachol.	Carbachol	130-139	claudin 4	Rattus norvegicus	75-84
25948584-7	2015	Mutagenesis assay demonstrated that S195, but not S199, S203 or S207, of claudin-4, was the target for carbachol.	Carbachol	103-112	claudin 4	Rattus norvegicus	73-82
25788576-9	2015	In HEK293 cells transfected with the M2 muscarinic receptor, the application of carbachol increased the FRET efficiency between TRPC4beta-CFP and Galphai2(WT)-YFP from 4.7 +- 0.4% (n = 7) to 12.6 +- 1.4% (n = 7).	Carbachol	80-89	complement factor properdin	Homo sapiens	138-141
25788576-12	2015	In response to the muscarinic agonist carbachol, M2-, Galphai2-, and TRPC4-expressing cells showed a prolonged Ca(2+) influx compared with cells expressing only M2.	Carbachol	38-47	transient receptor potential cation channel subfamily C member 4	Homo sapiens	69-74
26742661-8	2015	Since the same response is elicited at a lower level by CBL administration, the hypothesis of an involvement of cholinoceptive ORX neurons in its generation is discussed.	Carbachol	56-59	hypocretin neuropeptide precursor	Rattus norvegicus	127-130
25382267-0	2015	The Role of Rac1 on Carbachol-induced Contractile Activity in Detrusor Smooth Muscle from Streptozotocin-induced Diabetic Rats.	Carbachol	20-29	Rac family small GTPase 1	Rattus norvegicus	12-16
25382267-1	2015	This study was designed to determine the role of the small GTPase Rac1 on carbachol-induced contractile activity in detrusor smooth muscle using small inhibitor NSC 23766 in diabetic rats.	Carbachol	74-83	Rac family small GTPase 1	Rattus norvegicus	66-70
25382267-8	2015	Rac1 inhibitor NSC 23766 inhibited CCh-induced contractile responses in all groups, but this inhibition seen in both diabetes groups was greater than in the control group.	Carbachol	35-38	Rac family small GTPase 1	Rattus norvegicus	0-4
25382267-11	2015	In the diabetic bladders, increased expression of Rac1 and considerable inhibition of CCh-induced responses in the presence of NSC 23766 compared to those of the control group may indicate a specific role of Rac1 in diabetes-related bladder dysfunction, especially associated with cholinergic mediated detrusor overactivity.	Carbachol	86-89	Rac family small GTPase 1	Rattus norvegicus	208-212
26021821-6	2015	Glucagon partially inhibited carbachol-induced tracheal contraction in a mechanism clearly sensitive to des-His1-[Glu9]-glucagon amide, a GcgR antagonist.	Carbachol	29-38	glucagon receptor	Mus musculus	138-142
25911613-4	2015	Carbachol-induced vasodilatation was increased in arteries from the RBP4-KO compared with the WT mice and was impaired in the RBP4-Tg mice.	Carbachol	0-9	retinol binding protein 4, plasma	Mus musculus	68-72
25911613-4	2015	Carbachol-induced vasodilatation was increased in arteries from the RBP4-KO compared with the WT mice and was impaired in the RBP4-Tg mice.	Carbachol	0-9	retinol binding protein 4, plasma	Mus musculus	126-130
25680367-6	2015	At the cellular level, carbachol induced an increase in the intracellular [Ca(2+)] that was more than 2-fold larger in PG and SMG than in SLG acinar cells.	Carbachol	23-32	small nuclear ribonucleoprotein polypeptide G	Mus musculus	126-129
24974903-9	2015	Ano1 is located in a basolateral compartment/membrane rather than in the apical membrane, where it supports CCH-induced Ca(2+) increase, while the essential and possibly only apical Cl(-) channel is CFTR.	Carbachol	108-111	anoctamin 1, calcium activated chloride channel	Mus musculus	0-4
26084221-8	2015	The decrease observed in the CCh-stimulated HCO3(-) response in M4 KO mice was reversed by the co-application of CYN154806, a somatostatin receptor type 2 (SST2) antagonist.	Carbachol	29-32	somatostatin receptor 2	Mus musculus	126-154
26084221-8	2015	The decrease observed in the CCh-stimulated HCO3(-) response in M4 KO mice was reversed by the co-application of CYN154806, a somatostatin receptor type 2 (SST2) antagonist.	Carbachol	29-32	somatostatin receptor 2	Mus musculus	156-160
26084221-9	2015	Octreotide (a somatostatin analogue) decreased the basal and CCh-stimulated secretion of HCO3(-) in wild-type mice.	Carbachol	61-64	somatostatin	Mus musculus	14-26
25680367-7	2015	Carbachol-stimulated Cl(-) efflux and the protein levels of the Ca(2+)-activated Cl(-) channel TMEM16A, the major apical Cl(-) efflux pathway in salivary acinar cells, were significantly greater in PG compared with SMG and SLG.	Carbachol	0-9	anoctamin 1, calcium activated chloride channel	Mus musculus	95-102
25680367-7	2015	Carbachol-stimulated Cl(-) efflux and the protein levels of the Ca(2+)-activated Cl(-) channel TMEM16A, the major apical Cl(-) efflux pathway in salivary acinar cells, were significantly greater in PG compared with SMG and SLG.	Carbachol	0-9	small nuclear ribonucleoprotein polypeptide G	Mus musculus	215-218
25639149-10	2015	We also found that desipramine inhibits the increase in membrane aquaporin-5 level triggered by carbachol and histamine treatments.	Carbachol	96-105	aquaporin 5	Homo sapiens	65-76
25910195-10	2015	These mice exhibited endothelial dysfunction, increased amyloid-beta in cerebral microvessels, decreases in carbachol-induced pCREB and pERK formation in hippocampal slices, and brain atrophy.	Carbachol	108-117	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	136-140
24867682-3	2015	We used the mAChR agonist, carbachol, to determine the changes in KCa1.1 channel activity upon mAChR activation in freshly isolated human DSM cells obtained from open bladder surgeries using the perforated whole cell and single KCa1.1 channel patch-clamp recordings.	Carbachol	27-36	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	66-72
24867682-5	2015	Carbachol inhibited the amplitude and frequency of KCa1.1 channel-mediated spontaneous transient outward currents and spontaneous transient hyperpolarizations, which are triggered by the release of Ca(2+) from ryanodine receptors.	Carbachol	0-9	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	51-57
24867682-6	2015	Carbachol also caused membrane potential depolarization, which was not observed in the presence of iberiotoxin, a KCa1.1 channel inhibitor, indicating the critical role of the KCa1.1 channels.	Carbachol	0-9	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	114-120
24867682-6	2015	Carbachol also caused membrane potential depolarization, which was not observed in the presence of iberiotoxin, a KCa1.1 channel inhibitor, indicating the critical role of the KCa1.1 channels.	Carbachol	0-9	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	176-182
24867682-7	2015	The potential direct carbachol effects on KCa1.1 channels were examined under conditions of removing the major cellular Ca(2+) sources for KCa1.1 channel activation with pharmacological inhibitors (thapsigargin, ryanodine, and nifedipine).	Carbachol	21-30	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	42-48
25730677-8	2015	A marked but not full overlap was observed: all neurons depolarized by carbachol were depolarized by the CB1 receptor agonist ACEA, and all neurons lacking response to carbachol lacked response to ACEA as well.	Carbachol	71-80	cannabinoid receptor 1 (brain)	Mus musculus	105-108
25567809-5	2015	l-cysteine, an activator of CSE, and NaHS, a donor of H2S, inhibited carbachol-induced Rho kinase and PKC activity, Rho kinase-sensitive phosphorylation of MYPT1, PKC-sensitive phosphorylation of CPI-17, and MLC20 phosphorylation and sustained muscle contraction.	Carbachol	69-78	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	156-161
25567809-5	2015	l-cysteine, an activator of CSE, and NaHS, a donor of H2S, inhibited carbachol-induced Rho kinase and PKC activity, Rho kinase-sensitive phosphorylation of MYPT1, PKC-sensitive phosphorylation of CPI-17, and MLC20 phosphorylation and sustained muscle contraction.	Carbachol	69-78	protein phosphatase 1 regulatory inhibitor subunit 14A	Homo sapiens	196-202
25567809-5	2015	l-cysteine, an activator of CSE, and NaHS, a donor of H2S, inhibited carbachol-induced Rho kinase and PKC activity, Rho kinase-sensitive phosphorylation of MYPT1, PKC-sensitive phosphorylation of CPI-17, and MLC20 phosphorylation and sustained muscle contraction.	Carbachol	69-78	myosin light chain 12B	Homo sapiens	208-213
25398705-8	2015	By analyzing tear secretion induced with carbachol in presence of a P2Y2 receptor siRNA, we found that tear secretion was diminished to 60 %.	Carbachol	41-50	LOC100009486	Oryctolagus cuniculus	68-81
25421240-4	2014	Stimulation with the cholinergic agonist carbachol leads to activation of the MAP kinase extracellular signal regulated kinase, together with the protein kinase Akt.	Carbachol	41-50	AKT serine/threonine kinase 1	Homo sapiens	161-164
25537671-7	2015	The contractility in response to carbachol was significantly decreased in the proximal colon of IL-10(-/-) mice compared to IL-10(+/+) mice, but no significant difference was found in the distal colon.	Carbachol	33-42	interleukin 10	Mus musculus	96-101
25537671-7	2015	The contractility in response to carbachol was significantly decreased in the proximal colon of IL-10(-/-) mice compared to IL-10(+/+) mice, but no significant difference was found in the distal colon.	Carbachol	33-42	interleukin 10	Mus musculus	124-129
25557225-9	2015	Application of ML-7 (MLCK inhibitor) during CCh-induced sustained contraction elicited an MLCP-dependent relaxation, the rate of which was accelerated by application of PD98059 and SB203580 with proportional changes in LC20 phosphorylation levels but not MYPT1 phosphorylation (Thr697 or Thr855).	Carbachol	44-47	myosin light chain kinase	Rattus norvegicus	21-25
25557225-10	2015	CONCLUSIONS &amp; INFERENCES: ERK and p38MAPK contribute to CCh-induced sustained contraction in a LC20 phosphorylation dependent manner.	Carbachol	60-63	Eph receptor B1	Rattus norvegicus	30-33
25660359-0	2015	beta-Adrenoceptor-Mediated Relaxation of Carbachol-Pre-Contracted Mouse Detrusor.	Carbachol	41-50	adrenergic receptor, beta 1	Mus musculus	0-17
25660359-1	2015	AIMS: To study the beta-adrenoceptor subtypes involved in the relaxation responses to (-)-isoprenaline in carbachol-pre-contracted (CCh) mouse detrusor muscle with intact and denuded mucosa.	Carbachol	106-115	adrenergic receptor, beta 1	Mus musculus	19-36
26068049-4	2015	KCl- or carbachol-precontracted strips were relaxed with increasing concentrations of noradrenaline in the absence and in the presence of nitric oxide synthase inhibitor, L-NAME; P2X-receptor antagonist, PPADS; ETA-receptor antagonist, BQ-123; ETB-receptor antagonist, BQ-788; cyclooxygenase inhibitor, diclofenac; AT1-receptor antagonist, candesartan; and NK1-receptor antagonist, L-703,606.	Carbachol	8-17	tachykinin receptor 1	Homo sapiens	357-369
25242372-7	2014	CCh triggered the activation of the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule (STIM) 1, as indicated by redistribution of STIM1 immunofluorescence into puncta, and promoted the association of STIM1 with the SOCE channel component Orai1.	Carbachol	0-3	stromal interaction molecule 1	Homo sapiens	72-109
25242372-7	2014	CCh triggered the activation of the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule (STIM) 1, as indicated by redistribution of STIM1 immunofluorescence into puncta, and promoted the association of STIM1 with the SOCE channel component Orai1.	Carbachol	0-3	stromal interaction molecule 1	Homo sapiens	145-150
25242372-7	2014	CCh triggered the activation of the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule (STIM) 1, as indicated by redistribution of STIM1 immunofluorescence into puncta, and promoted the association of STIM1 with the SOCE channel component Orai1.	Carbachol	0-3	stromal interaction molecule 1	Homo sapiens	215-220
25242372-7	2014	CCh triggered the activation of the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule (STIM) 1, as indicated by redistribution of STIM1 immunofluorescence into puncta, and promoted the association of STIM1 with the SOCE channel component Orai1.	Carbachol	0-3	ORAI calcium release-activated calcium modulator 1	Homo sapiens	253-258
25242372-8	2014	Cell depletion of STIM1 by siRNA treatment reduced both CCh-induced [Ca(2+)]i plateau and AMPK activation.	Carbachol	56-59	stromal interaction molecule 1	Homo sapiens	18-23
25431134-1	2015	Parathyroid hormone (PTH) stimulates adenylyl cyclase through type 1 PTH receptors (PTH1R) and potentiates the Ca(2+) signals evoked by carbachol, which stimulates formation of inositol 1,4,5-trisphosphate (IP3).	Carbachol	136-145	parathyroid hormone	Homo sapiens	0-19
25431134-1	2015	Parathyroid hormone (PTH) stimulates adenylyl cyclase through type 1 PTH receptors (PTH1R) and potentiates the Ca(2+) signals evoked by carbachol, which stimulates formation of inositol 1,4,5-trisphosphate (IP3).	Carbachol	136-145	parathyroid hormone	Homo sapiens	21-24
25431134-2	2015	We confirmed that in HEK cells expressing PTH1R, acute stimulation with PTH(1-34) potentiated carbachol-evoked Ca(2+) release.	Carbachol	94-103	parathyroid hormone 1 receptor	Homo sapiens	42-47
25431134-2	2015	We confirmed that in HEK cells expressing PTH1R, acute stimulation with PTH(1-34) potentiated carbachol-evoked Ca(2+) release.	Carbachol	94-103	parathyroid hormone	Homo sapiens	42-45
25431134-5	2015	Here, we show that sustained stimulation with PTH(1-34) or with PTH analogues that do not evoke receptor internalization reduced the potentiated Ca(2+) signals and attenuated carbachol-evoked increases in cytosolic IP3.	Carbachol	175-184	parathyroid hormone	Homo sapiens	46-49
25431134-5	2015	Here, we show that sustained stimulation with PTH(1-34) or with PTH analogues that do not evoke receptor internalization reduced the potentiated Ca(2+) signals and attenuated carbachol-evoked increases in cytosolic IP3.	Carbachol	175-184	parathyroid hormone	Homo sapiens	64-67
25234725-9	2014	Results suggest that acetylcholine and short-term electrical stimulation reduce GDNF secretion, while treatment with carbachol or long-term electrical stimulation enhances GDNF production by skeletal muscle.	Carbachol	117-126	glial cell derived neurotrophic factor	Homo sapiens	172-176
24846346-4	2014	RESULTS: In bladder strips from non-diabetic animals, the presence of the urothelium resulted in marked sensitivity to carbachol-induced force generation by modulators of MaxiK and Kv7 channel activity, whereas in the diabetic animal urothelial sensitivity to these agents was significantly diminished.	Carbachol	119-128	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	171-176
24990429-7	2014	KEY RESULTS: The cholinoceptor agonist carbachol was more effective at stimulating proliferation in iNIH3T3 than in NIH3T3 cells, probably due to the de novo induction of M3 and M5 muscarinic receptors independently of NF-kappaB activation.	Carbachol	39-48	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	219-228
24990429-11	2014	Inflammation also up-regulated the expression of NOS and COX-2, thus potentiating the effect of carbachol on NO and PGE2 production.	Carbachol	96-105	cytochrome c oxidase II, mitochondrial	Mus musculus	57-62
25230765-7	2014	Ghrelin enhanced smooth muscle strip contraction induced by CCh, but when CCh was absent, this effect was eliminated.	Carbachol	60-63	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
25230765-11	2014	In conclusion the present study demonstrated that ghrelin may act as an adjuvant to regulate gastric smooth muscle contraction induced by CCh through GHS-R1s, which are expressed on myenteric nerve cells, Cajal cells and smooth muscle cells.	Carbachol	138-141	ghrelin and obestatin prepropeptide	Rattus norvegicus	50-57
25375115-9	2014	Menthol (300 microM) or nifedipine (1 microM) inhibited carbachol and EFS-induced contractions in both wild type and TRPM8 knockout bladder strips.	Carbachol	56-65	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	117-122
26417327-10	2014	Additionally, the blockade of Ox1r in the VTA by SB334867 can attenuate the conditioning score induced by concurrent administration of carbachol and an ineffective dose of morphine.	Carbachol	135-144	hypocretin receptor 1	Rattus norvegicus	30-34
25031220-5	2014	Results indicate that mGluR5 activation promotes feed-forward inhibition that depends on recruitment of neuronal activity by carbachol-evoked up states.	Carbachol	125-134	glutamate receptor, ionotropic, kainate 1	Mus musculus	22-28
25031220-6	2014	The rate of neuronal spiking activity under the influence of carbachol was reduced by the mGluR5 positive allosteric modulator, N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide (VU-29), and enhanced by the mGluR5 negative allosteric modulator, 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride (MTEP).	Carbachol	61-70	glutamate receptor, ionotropic, kainate 1	Mus musculus	90-96
25031220-6	2014	The rate of neuronal spiking activity under the influence of carbachol was reduced by the mGluR5 positive allosteric modulator, N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide (VU-29), and enhanced by the mGluR5 negative allosteric modulator, 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride (MTEP).	Carbachol	61-70	glutamate receptor, ionotropic, kainate 1	Mus musculus	208-214
25106095-4	2014	In neonatal rat ventricular myocytes (NRVMs), sphingosine 1-phosphate (S1P), lysophosphatidic acid (LPA) and endothelin-1 induced robust increases in CCN1 expression while phenylephrine, isoproterenol and carbachol had little or no effect.	Carbachol	205-214	endothelin 1	Rattus norvegicus	109-121
24628494-10	2014	Based on this highly reliable assay, 50% of the pSS patients had antibodies which inhibited carbachol-induced activation of mAchR3; none of the SSc patients, 6% of the patients with MG and 12% of the blood donors had antibodies which reacted with the mAchR3.	Carbachol	92-101	cholinergic receptor, nicotinic, gamma polypeptide	Mus musculus	124-130
24835173-5	2014	Isolated MYPT1-deficient tissues from MYPT1(SM-/-) mice contracted with moderate differences in response to KCl and carbachol treatments, and relaxed rapidly with comparable rates after carbachol removal and only 1.5-fold slower after KCl removal.	Carbachol	116-125	protein phosphatase 1, regulatory subunit 12A	Mus musculus	9-14
24835173-5	2014	Isolated MYPT1-deficient tissues from MYPT1(SM-/-) mice contracted with moderate differences in response to KCl and carbachol treatments, and relaxed rapidly with comparable rates after carbachol removal and only 1.5-fold slower after KCl removal.	Carbachol	186-195	protein phosphatase 1, regulatory subunit 12A	Mus musculus	9-14
24928903-5	2014	Carbachol (CCH) and forskolin (FSK) stimulated NHE3 endocytosis in control but not in myosin VI KD cells.	Carbachol	0-9	solute carrier family 9 member A3	Homo sapiens	47-51
24928903-5	2014	Carbachol (CCH) and forskolin (FSK) stimulated NHE3 endocytosis in control but not in myosin VI KD cells.	Carbachol	11-14	solute carrier family 9 member A3	Homo sapiens	47-51
24828459-5	2014	SMG innervation could be restored by the acetylcholine analog carbachol (CCh), which also rescued cytokeratin 5 (CK5(+))-expressing epithelial progenitor cells.	Carbachol	62-71	keratin 5	Homo sapiens	98-111
24828459-5	2014	SMG innervation could be restored by the acetylcholine analog carbachol (CCh), which also rescued cytokeratin 5 (CK5(+))-expressing epithelial progenitor cells.	Carbachol	73-76	keratin 5	Homo sapiens	98-111
24628494-10	2014	Based on this highly reliable assay, 50% of the pSS patients had antibodies which inhibited carbachol-induced activation of mAchR3; none of the SSc patients, 6% of the patients with MG and 12% of the blood donors had antibodies which reacted with the mAchR3.	Carbachol	92-101	cholinergic receptor, nicotinic, gamma polypeptide	Mus musculus	251-257
24522860-4	2014	RESULTS: Activation of M3 mAChR with carbachol increased both IL-8 mRNA and protein expression in a concentration-dependent manner.	Carbachol	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
24867958-0	2014	NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.	Carbachol	120-129	SLC9A3 regulator 2	Homo sapiens	0-6
24867958-0	2014	NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.	Carbachol	120-129	PDZ domain containing 1	Homo sapiens	7-13
24867958-0	2014	NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.	Carbachol	120-129	solute carrier family 9 member A3	Homo sapiens	103-107
24867958-11	2014	This study suggests that NHERF2/NHERF3 heterodimerization mediates the formation of NHE3 macrocomplexes, which are required for the inhibition of NHE3 activity by carbachol.	Carbachol	163-172	SLC9A3 regulator 2	Homo sapiens	25-31
24867958-11	2014	This study suggests that NHERF2/NHERF3 heterodimerization mediates the formation of NHE3 macrocomplexes, which are required for the inhibition of NHE3 activity by carbachol.	Carbachol	163-172	PDZ domain containing 1	Homo sapiens	32-38
24867958-11	2014	This study suggests that NHERF2/NHERF3 heterodimerization mediates the formation of NHE3 macrocomplexes, which are required for the inhibition of NHE3 activity by carbachol.	Carbachol	163-172	solute carrier family 9 member A3	Homo sapiens	84-88
24867958-11	2014	This study suggests that NHERF2/NHERF3 heterodimerization mediates the formation of NHE3 macrocomplexes, which are required for the inhibition of NHE3 activity by carbachol.	Carbachol	163-172	solute carrier family 9 member A3	Homo sapiens	146-150
24522860-7	2014	Furthermore, M3 mAChR-mediated NF-kappaB activation and IL-8 expression were simultaneously attenuated by the PKC inhibitor calphostin C, whereas PMA, a PKC activator, mimicked the effects of carbachol, inducing IL-8 expression.	Carbachol	192-201	proline rich transmembrane protein 2	Homo sapiens	110-113
24688054-6	2014	Treatment of cells with carbachol reduced the hERG-ubiquitin interaction and slowed the rate of hERG degradation.	Carbachol	24-33	ETS transcription factor ERG	Homo sapiens	46-50
24688054-6	2014	Treatment of cells with carbachol reduced the hERG-ubiquitin interaction and slowed the rate of hERG degradation.	Carbachol	24-33	ETS transcription factor ERG	Homo sapiens	96-100
24688054-8	2014	Here, we found that disrupting the Nedd4-2 binding domain in hERG completely eliminated the effect of carbachol on hERG channels.	Carbachol	102-111	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	35-42
24688054-8	2014	Here, we found that disrupting the Nedd4-2 binding domain in hERG completely eliminated the effect of carbachol on hERG channels.	Carbachol	102-111	ETS transcription factor ERG	Homo sapiens	61-65
24688054-8	2014	Here, we found that disrupting the Nedd4-2 binding domain in hERG completely eliminated the effect of carbachol on hERG channels.	Carbachol	102-111	ETS transcription factor ERG	Homo sapiens	115-119
24688054-9	2014	Carbachol treatment enhanced the phosphorylation level, but not the total level, of Nedd4-2.	Carbachol	0-9	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	84-91
24688054-10	2014	Blockade of the protein kinase C (PKC) pathway abolished the carbachol-induced enhancement of hERG channels.	Carbachol	61-70	ETS transcription factor ERG	Homo sapiens	94-98
24487025-8	2014	Parasympathetic nerve activation by carbachol infusion for 5 days in rats increased serum adiponectin, with increased adiponectin production in visceral and subcutaneous adipose tissues without changes of body weight.	Carbachol	36-45	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	90-101
24652077-3	2014	The effect of CB1 agonist (ACEA) on carbachol- and ATP-induced changes in intracellular calcium ([Ca(2+)]i) levels was measured using fluorimetry.	Carbachol	36-45	cannabinoid receptor 1	Homo sapiens	14-17
24623142-8	2014	Therefore, the increase in CCh-induced fluid secretion in response to hypotonic conditions can be attributed, to a large extent, to the specific activation of the NKCC1.	Carbachol	27-30	solute carrier family 12, member 2	Mus musculus	163-168
24688054-4	2014	Using cell biology and electrophysiological methods, we found that the muscarinic receptor agonist carbachol increased the expression and function of hERG, but not ether-a-go-go or Kv1.5 channels stably expressed in human embryonic kidney cells.	Carbachol	99-108	ETS transcription factor ERG	Homo sapiens	150-154
24688054-5	2014	The carbachol-mediated increase in hERG expression was abolished by the selective M3 antagonist 4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) but not by the M2 antagonist AF-DX 116 (11[[2-[(diethylamino)methyl]-1-piperidinyl]-acetyl]-5,11-dihydro-6H-pyrido[2,3-b] [1,4]benzodiazepine-6-one).	Carbachol	4-13	ETS transcription factor ERG	Homo sapiens	35-39
24695728-3	2014	The muscarinic receptor agonist carbachol activated ERK1/2 better in T1R3-depleted cells than in control cells.	Carbachol	32-41	mitogen-activated protein kinase 3	Mus musculus	52-58
24695728-3	2014	The muscarinic receptor agonist carbachol activated ERK1/2 better in T1R3-depleted cells than in control cells.	Carbachol	32-41	taste receptor, type 1, member 3	Mus musculus	69-73
24487025-8	2014	Parasympathetic nerve activation by carbachol infusion for 5 days in rats increased serum adiponectin, with increased adiponectin production in visceral and subcutaneous adipose tissues without changes of body weight.	Carbachol	36-45	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	118-129
24586057-3	2014	Here, we show that, in addition to suppressing carbachol-stimulated Ca(2+) release, Gbeta5-RGS7 enhanced Ca(2+) influx.	Carbachol	47-56	G protein subunit beta 5	Homo sapiens	84-90
24608858-6	2014	In addition, overexpression of DGKeta enhanced calcium mobilization after stimulating muscarinic receptors with carbachol and after stimulating purinergic receptors with ATP.	Carbachol	112-121	diacylglycerol kinase eta	Homo sapiens	31-37
24608858-8	2014	DGKeta was localized throughout the cytosol and did not translocate to the plasma membrane after stimulation with carbachol.	Carbachol	114-123	diacylglycerol kinase eta	Homo sapiens	0-6
24219573-8	2014	Human precision-cut lung slices treated with IL-13 caused a decrease in beta-agonist (formoterol)-mediated relaxation of carbachol-contracted airways compared with control slices.	Carbachol	121-130	interleukin 13	Homo sapiens	45-50
24365239-7	2014	Carbachol (CCh) increased ERK and FAK phosphorylation with enhanced TER recovery, which was completely blocked by either MT-7 (M1 antagonist) or atropine.	Carbachol	0-9	mitogen-activated protein kinase 1	Homo sapiens	26-29
24365239-7	2014	Carbachol (CCh) increased ERK and FAK phosphorylation with enhanced TER recovery, which was completely blocked by either MT-7 (M1 antagonist) or atropine.	Carbachol	0-9	protein tyrosine kinase 2	Homo sapiens	34-37
24365239-7	2014	Carbachol (CCh) increased ERK and FAK phosphorylation with enhanced TER recovery, which was completely blocked by either MT-7 (M1 antagonist) or atropine.	Carbachol	11-14	mitogen-activated protein kinase 1	Homo sapiens	26-29
24365239-7	2014	Carbachol (CCh) increased ERK and FAK phosphorylation with enhanced TER recovery, which was completely blocked by either MT-7 (M1 antagonist) or atropine.	Carbachol	11-14	protein tyrosine kinase 2	Homo sapiens	34-37
24365239-8	2014	The CCh-induced enhancement of TER recovery was also blocked by either U0126 (ERK pathway inhibitor) or PF-228 (FAK inhibitor).	Carbachol	4-7	mitogen-activated protein kinase 1	Homo sapiens	78-81
24365239-8	2014	The CCh-induced enhancement of TER recovery was also blocked by either U0126 (ERK pathway inhibitor) or PF-228 (FAK inhibitor).	Carbachol	4-7	protein tyrosine kinase 2	Homo sapiens	112-115
24365239-10	2014	The CCh-induced ERK and FAK phosphorylation were also attenuated by the IFN-gamma treatment.	Carbachol	4-7	mitogen-activated protein kinase 1	Homo sapiens	16-19
24365239-10	2014	The CCh-induced ERK and FAK phosphorylation were also attenuated by the IFN-gamma treatment.	Carbachol	4-7	protein tyrosine kinase 2	Homo sapiens	24-27
24365239-10	2014	The CCh-induced ERK and FAK phosphorylation were also attenuated by the IFN-gamma treatment.	Carbachol	4-7	interferon gamma	Homo sapiens	72-81
24678619-8	2014	Moreover, carbachol induced TGF-beta1 production from A549 cells concomitantly with the EMT process.	Carbachol	10-19	transforming growth factor beta 1	Homo sapiens	28-37
24678619-9	2014	Carbachol-induced EMT occurred through phosphorylation of Smad2/3 and ERK, which was inhibited by pirenzepine and 4-DAMP.	Carbachol	0-9	SMAD family member 2	Homo sapiens	58-65
24678619-9	2014	Carbachol-induced EMT occurred through phosphorylation of Smad2/3 and ERK, which was inhibited by pirenzepine and 4-DAMP.	Carbachol	0-9	mitogen-activated protein kinase 1	Homo sapiens	70-73
24642792-5	2014	The conventional and novel PKC inhibitors Go6976 or Go6850 did not alter NBC function or surface expression by themselves, but stimulation with forskolin (10(-5) M) or carbachol (10(-4) M) in their presence led to a significant decrease in NBC-mediated proton flux, and biotinylated NBCe1.	Carbachol	168-177	solute carrier family 4 (anion exchanger), member 4	Mus musculus	240-243
24607024-9	2014	RESULTS: Prolonged culture of ASMCs with acetylcholine, carbachol or FBS, reduced the expression of alpha-actin, desmin and SM-MHC compared to cells cultured in serum free medium.	Carbachol	56-65	desmin	Oryctolagus cuniculus	113-119
24607024-9	2014	RESULTS: Prolonged culture of ASMCs with acetylcholine, carbachol or FBS, reduced the expression of alpha-actin, desmin and SM-MHC compared to cells cultured in serum free medium.	Carbachol	56-65	myosin-11	Oryctolagus cuniculus	124-130
24485888-5	2014	Activation of Galphaq proteins was also detectable by the addition of carbachol via muscarinic acetylcholine M1 receptors, (-)-epinephrine, and dopamine, but not by L-glutamate or (+-)-baclofen.	Carbachol	70-79	G protein subunit alpha q	Rattus norvegicus	14-21
24356881-4	2014	The aim of this study was to identify the role of BDNF in carbachol (CCh)- and substance P (SP)-induced contraction of intestinal longitudinal smooth muscle.	Carbachol	58-67	LOW QUALITY PROTEIN: brain-derived neurotrophic factor	Oryctolagus cuniculus	50-54
24630173-5	2014	In contrast, Ca(2+) signals to carbachol were significantly increased in ApoE(-/-) cells, an effect methyl-beta-cyclodextrin reversed.	Carbachol	31-40	apolipoprotein E	Mus musculus	73-77
24630173-9	2014	In conclusion, carbachol-induced calcium signalling and handling are significantly altered in endothelial cells of ApoE(-/-) mice before plaque development.	Carbachol	15-24	apolipoprotein E	Mus musculus	115-119
24389807-8	2014	Carbachol (10 microM) increased the ratio of non-lipid microdomain to total AQP5 in the cultured control submandibular gland tissue.	Carbachol	0-9	aquaporin 5	Homo sapiens	76-80
24558448-7	2014	3/Wash-resistant xanomeline selectively prevented further increase in intracellular calcium by carbachol at hM1 and hM4 receptors.	Carbachol	95-104	cholinergic receptor muscarinic 1	Homo sapiens	108-111
24356881-4	2014	The aim of this study was to identify the role of BDNF in carbachol (CCh)- and substance P (SP)-induced contraction of intestinal longitudinal smooth muscle.	Carbachol	69-72	LOW QUALITY PROTEIN: brain-derived neurotrophic factor	Oryctolagus cuniculus	50-54
24356881-7	2014	One-hour preincubation with BDNF enhanced intestinal muscle contraction induced by CCh but not by SP.	Carbachol	83-86	LOW QUALITY PROTEIN: brain-derived neurotrophic factor	Oryctolagus cuniculus	28-32
24356881-10	2014	The enhancement of CCh-induced contraction by BDNF was blocked by the phospholipase C (PLC) antagonist U73122, but not by ERK1/2 or Akt antagonists.	Carbachol	19-22	LOW QUALITY PROTEIN: brain-derived neurotrophic factor	Oryctolagus cuniculus	46-50
24356881-10	2014	The enhancement of CCh-induced contraction by BDNF was blocked by the phospholipase C (PLC) antagonist U73122, but not by ERK1/2 or Akt antagonists.	Carbachol	19-22	LOC100009319	Oryctolagus cuniculus	70-85
24356881-10	2014	The enhancement of CCh-induced contraction by BDNF was blocked by the phospholipase C (PLC) antagonist U73122, but not by ERK1/2 or Akt antagonists.	Carbachol	19-22	LOC100009319	Oryctolagus cuniculus	87-90
24356881-12	2014	We conclude that exogenous BDNF augments the CCh-induced contraction of longitudinal muscle from rabbit intestine by activating TrkB receptors and subsequent PLC activation.	Carbachol	45-48	LOW QUALITY PROTEIN: brain-derived neurotrophic factor	Oryctolagus cuniculus	27-31
24356881-12	2014	We conclude that exogenous BDNF augments the CCh-induced contraction of longitudinal muscle from rabbit intestine by activating TrkB receptors and subsequent PLC activation.	Carbachol	45-48	LOC100009319	Oryctolagus cuniculus	158-161
23827485-7	2014	With human bronchial rings, we observed that whatever the compound used including salbutamol, the activation of muscular CFTR leads to a bronchodilation after constriction with carbachol.	Carbachol	177-186	CF transmembrane conductance regulator	Homo sapiens	121-125
24269928-6	2014	Carbachol concentration-dependently enhanced the production of IL-1beta-induced IL-6 and IL-8, which was blocked by the simultaneous addition of tiotropium.	Carbachol	0-9	interleukin 6	Homo sapiens	80-84
24269928-6	2014	Carbachol concentration-dependently enhanced the production of IL-1beta-induced IL-6 and IL-8, which was blocked by the simultaneous addition of tiotropium.	Carbachol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
24269928-8	2014	Olodaterol induced cAMP and the phosphorylation of CREB, an effect counteracted by carbachol, but rescued by tiotropium.	Carbachol	83-92	cAMP responsive element binding protein 1	Homo sapiens	51-55
24190932-10	2014	The low-frequency IPSC oscillations induced by CCh or optogenetically stimulated ACh release were also inhibited by a mu-opioid receptor (MOR) agonist, which was unexpected because MORs in CA1 are not usually associated with CCK-expressing cells.	Carbachol	47-50	opioid receptor mu 1	Homo sapiens	118-136
24318880-6	2014	In retrogradely perfused hearts, ablation of RGS6, but not RGS4, correlated with decreased resting HR, increased heart rate variability, and enhanced sensitivity to the negative chronotropic effects of the muscarinic agonist carbachol.	Carbachol	225-234	regulator of G-protein signaling 6	Mus musculus	45-49
24318880-7	2014	Similarly, loss of RGS6, but not RGS4, correlated with enhanced sensitivity of the M2R-IKACh signaling pathway in SAN cells to carbachol and a significant slowing of M2R-IKACh deactivation rate.	Carbachol	127-136	regulator of G-protein signaling 6	Mus musculus	19-23
24122009-2	2014	The aim of this study was to determine the relative contributions of MLCK and ROCK to carbachol-induced contraction of human detrusor smooth muscle in vitro.	Carbachol	86-95	myosin light chain kinase	Homo sapiens	69-73
24122009-6	2014	Pre-incubation of detrusor specimens with either the MLCK inhibitor ML-9 or the ROCK inhibitors HA1100 and Y-27632 (each at 10 mumol/L) significantly blocked carbachol-induced contractions as compared to the time-control experiments.	Carbachol	158-167	myosin light chain kinase	Homo sapiens	53-57
24122009-7	2014	Moreover, MLCK and ROCK inhibition were equally effective in reducing carbachol-induced contractions.	Carbachol	70-79	myosin light chain kinase	Homo sapiens	10-14
24122009-8	2014	The residual carbachol-induced contractions in the presence of both MLCK and ROCK inhibitors were significantly smaller than the contractions obtained when only one enzyme (either MLCK or ROCK) was inhibited, suggesting an additive effect of the two kinases.	Carbachol	13-22	myosin light chain kinase	Homo sapiens	68-72
24122009-8	2014	The residual carbachol-induced contractions in the presence of both MLCK and ROCK inhibitors were significantly smaller than the contractions obtained when only one enzyme (either MLCK or ROCK) was inhibited, suggesting an additive effect of the two kinases.	Carbachol	13-22	myosin light chain kinase	Homo sapiens	180-184
24122009-10	2014	CONCLUSION: Both MLCK and ROCK contribute to carbachol-induced contractions of human detrusor smooth muscle.	Carbachol	45-54	myosin light chain kinase	Homo sapiens	17-21
24713550-0	2014	Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42.	Carbachol	0-9	solute carrier family 9 member A3	Homo sapiens	34-38
24713550-0	2014	Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42.	Carbachol	0-9	cell division cycle 42	Homo sapiens	107-112
24713550-3	2014	Carbachol (CCH), which elevates intracellular Ca(2+) ([Ca(2+)]i), decreases NHE3 activity and stimulates endocytosis; however, the mechanism involved in calcium-mediated endocytosis of NHE3 is unclear.	Carbachol	0-9	solute carrier family 9 member A3	Homo sapiens	76-80
24713550-3	2014	Carbachol (CCH), which elevates intracellular Ca(2+) ([Ca(2+)]i), decreases NHE3 activity and stimulates endocytosis; however, the mechanism involved in calcium-mediated endocytosis of NHE3 is unclear.	Carbachol	0-9	solute carrier family 9 member A3	Homo sapiens	185-189
24713550-3	2014	Carbachol (CCH), which elevates intracellular Ca(2+) ([Ca(2+)]i), decreases NHE3 activity and stimulates endocytosis; however, the mechanism involved in calcium-mediated endocytosis of NHE3 is unclear.	Carbachol	11-14	solute carrier family 9 member A3	Homo sapiens	76-80
24713550-3	2014	Carbachol (CCH), which elevates intracellular Ca(2+) ([Ca(2+)]i), decreases NHE3 activity and stimulates endocytosis; however, the mechanism involved in calcium-mediated endocytosis of NHE3 is unclear.	Carbachol	11-14	solute carrier family 9 member A3	Homo sapiens	185-189
24713550-9	2014	In contrast, CCH-inhibition of NHE3 activity was abolished in Caco-2/BBe cells treated with MbetaCD (to disrupt lipid rafts) as well as in Cdc42 knockdown cells but was unaffected by CME blockers.	Carbachol	13-16	solute carrier family 9 member A3	Homo sapiens	31-35
24713550-9	2014	In contrast, CCH-inhibition of NHE3 activity was abolished in Caco-2/BBe cells treated with MbetaCD (to disrupt lipid rafts) as well as in Cdc42 knockdown cells but was unaffected by CME blockers.	Carbachol	13-16	cell division cycle 42	Homo sapiens	139-144
24713550-10	2014	CONCLUSION: CCH-mediated inhibition of NHE3 activity is not dependent on clathrin and involves lipid rafts and requires Cdc42.	Carbachol	12-15	solute carrier family 9 member A3	Homo sapiens	39-43
24713550-10	2014	CONCLUSION: CCH-mediated inhibition of NHE3 activity is not dependent on clathrin and involves lipid rafts and requires Cdc42.	Carbachol	12-15	cell division cycle 42	Homo sapiens	120-125
24604007-0	2014	The C. elegans VIG-1 and FRM-1 modulate carbachol-stimulated ERK1/2 activation in chinese hamster ovary cells expressing the muscarinic acetylcholine receptor GAR-3.	Carbachol	40-49	HABP4_PAI-RBP1 domain-containing protein	Caenorhabditis elegans	15-20
24604007-0	2014	The C. elegans VIG-1 and FRM-1 modulate carbachol-stimulated ERK1/2 activation in chinese hamster ovary cells expressing the muscarinic acetylcholine receptor GAR-3.	Carbachol	40-49	Moesin/ezrin/radixin homolog 1	Caenorhabditis elegans	25-30
24604007-0	2014	The C. elegans VIG-1 and FRM-1 modulate carbachol-stimulated ERK1/2 activation in chinese hamster ovary cells expressing the muscarinic acetylcholine receptor GAR-3.	Carbachol	40-49	Muscarinic acetylcholine receptor gar-3	Caenorhabditis elegans	159-164
24604007-6	2014	When VIG-1 was transiently expressed in GAR-3/CHO cells, carbachol-stimulated ERK1/2 activation was substantially reduced.	Carbachol	57-66	HABP4_PAI-RBP1 domain-containing protein	Caenorhabditis elegans	5-10
24604007-6	2014	When VIG-1 was transiently expressed in GAR-3/CHO cells, carbachol-stimulated ERK1/2 activation was substantially reduced.	Carbachol	57-66	Muscarinic acetylcholine receptor gar-3	Caenorhabditis elegans	40-45
24604007-7	2014	In contrast, transient expression of FRM-1 significantly enhanced carbachol-stimulated ERK1/2 activation.	Carbachol	66-75	Moesin/ezrin/radixin homolog 1	Caenorhabditis elegans	37-42
25069526-7	2014	Treatment with IL-17A for 12 h and 3 days attenuated carbachol- and membrane depolarization-induced contractions in organ-cultured rat ileum.	Carbachol	53-62	interleukin 17A	Rattus norvegicus	15-21
25891767-9	2014	Selective inhibitors of Rho kinase, ERK1/2, CaMKK/AMPK, and CaMKII each reduced carbachol-induced contraction in the innervated muscle strips.	Carbachol	80-89	mitogen activated protein kinase 3	Rattus norvegicus	36-42
25891767-11	2014	Thus unlike previously reported for isolated muscle cells where CaMKII and ERK1/2 are not involved in contraction, we conclude that the regulation of carbachol-induced contraction in innervated longitudinal muscle strips involves the interplay of Rho kinase, ERK1/2, CaMKK/AMPK, and CAMKII.	Carbachol	150-159	mitogen activated protein kinase 3	Rattus norvegicus	259-265
24190932-10	2014	The low-frequency IPSC oscillations induced by CCh or optogenetically stimulated ACh release were also inhibited by a mu-opioid receptor (MOR) agonist, which was unexpected because MORs in CA1 are not usually associated with CCK-expressing cells.	Carbachol	47-50	opioid receptor mu 1	Homo sapiens	138-141
24190932-10	2014	The low-frequency IPSC oscillations induced by CCh or optogenetically stimulated ACh release were also inhibited by a mu-opioid receptor (MOR) agonist, which was unexpected because MORs in CA1 are not usually associated with CCK-expressing cells.	Carbachol	47-50	carbonic anhydrase 1	Homo sapiens	189-192
24190932-10	2014	The low-frequency IPSC oscillations induced by CCh or optogenetically stimulated ACh release were also inhibited by a mu-opioid receptor (MOR) agonist, which was unexpected because MORs in CA1 are not usually associated with CCK-expressing cells.	Carbachol	47-50	cholecystokinin	Homo sapiens	225-228
23832809-9	2013	Carbachol-stimulated Ca(2+) levels were reduced in ECs from Trpc6(-/-) mice.	Carbachol	0-9	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	60-65
24377382-9	2013	However, combination of Cch with other mitogens exhibited a dual effect, synergistic proliferation effect in the presence of EGF (5 ng/mL) and 5% FBS and inhibiting the proliferation induced by 10% FBS, EGF (10 ng/mL) and TNF-alpha (10 ng/mL).	Carbachol	24-27	epidermal growth factor like 1	Rattus norvegicus	125-128
24377382-9	2013	However, combination of Cch with other mitogens exhibited a dual effect, synergistic proliferation effect in the presence of EGF (5 ng/mL) and 5% FBS and inhibiting the proliferation induced by 10% FBS, EGF (10 ng/mL) and TNF-alpha (10 ng/mL).	Carbachol	24-27	epidermal growth factor like 1	Rattus norvegicus	203-206
24377382-9	2013	However, combination of Cch with other mitogens exhibited a dual effect, synergistic proliferation effect in the presence of EGF (5 ng/mL) and 5% FBS and inhibiting the proliferation induced by 10% FBS, EGF (10 ng/mL) and TNF-alpha (10 ng/mL).	Carbachol	24-27	tumor necrosis factor	Rattus norvegicus	222-231
23941257-8	2013	In HCSMC, carbachol-induced calcium transients were inhibited by OB (EC50  = 8.4 muM).	Carbachol	10-19	latexin	Homo sapiens	81-84
23941257-9	2013	Carbachol evoked 1-a smooth muscle depolarization (10 mV) that was antagonized by 100 muM OB; and 2-a contraction that was inhibited by OB (EC50  = 13.0 muM).	Carbachol	0-9	latexin	Homo sapiens	86-89
23941257-9	2013	Carbachol evoked 1-a smooth muscle depolarization (10 mV) that was antagonized by 100 muM OB; and 2-a contraction that was inhibited by OB (EC50  = 13.0 muM).	Carbachol	0-9	latexin	Homo sapiens	153-156
23993687-5	2013	1 muM SA could markedly inhibit carbachol (CCh)-mediated increase PKC-delta, PKC-eta, and CPI-17 mRNA but had no effect in PKC-epsilon.Treatment of ISMC with SA (1 muM, 30 min) caused a decrease in protein expression of PKC-delta.	Carbachol	32-41	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	90-96
23993687-5	2013	1 muM SA could markedly inhibit carbachol (CCh)-mediated increase PKC-delta, PKC-eta, and CPI-17 mRNA but had no effect in PKC-epsilon.Treatment of ISMC with SA (1 muM, 30 min) caused a decrease in protein expression of PKC-delta.	Carbachol	43-46	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	90-96
24295263-6	2013	RESULTS: Endothelin 1, oxytocin, prostaglandin F2alpha, norepinephrine, and phenylephrine induced dose-dependent contraction of the isolated urethral tissue, whereas acetylcholine, carbachol, and angiotensin II had no or only minor contractile effects.	Carbachol	181-190	endothelin 1	Homo sapiens	9-21
24095671-5	2013	The pressor responses to ANG II (200ng/100nl) injected into the RVLM were reduced by acute (1 day) (12+-3 vs. sham lesions: 26+-4mmHg) or chronic (15 days) AV3V lesions (12+-5 vs. sham lesions: 27+-4mmHg), whereas acute or chronic AV3V lesions did not affect the pressor responses to carbachol (1nmol/100nl) injected into the RVLM.	Carbachol	284-293	angiotensinogen	Rattus norvegicus	25-31
23942896-8	2013	Perfusion of the entire submandibular gland with the TRPV1 agonist capsaicin (1 muM) via the submandibular artery significantly increased CCh-induced salivation, whereas perfusion with TRPM8 and TRPA1 agonists (0.5 muM WS12 and 100 muM allyl isothiocyanate) decreased it.	Carbachol	138-141	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-58
24004375-8	2013	PSA-released CGRP also evokes a transient hyperpolarization in TSMCs upon the opening of KATP channels, which reduces contraction propagation but promotes the recruitment of TSMC Ca(2+) channels that underlie the delayed positive inotropic effects of CCh.	Carbachol	251-254	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	13-17
24141119-3	2013	In this report, we first examined whether Abeta reduces alpha-secretase activity, and showed that Abeta peptide 1-40 (0.001 and 0.01 muM) reduced the secretion of soluble amyloid precursor protein alpha (sAPPalpha) in carbachol-stimulated SH-SY5Y neuroblastoma cells.	Carbachol	218-227	amyloid beta precursor protein	Homo sapiens	171-196
23942896-8	2013	Perfusion of the entire submandibular gland with the TRPV1 agonist capsaicin (1 muM) via the submandibular artery significantly increased CCh-induced salivation, whereas perfusion with TRPM8 and TRPA1 agonists (0.5 muM WS12 and 100 muM allyl isothiocyanate) decreased it.	Carbachol	138-141	latexin	Homo sapiens	80-83
23748234-7	2013	CCh-stimulated [(35)S]GTPgammaS binding to Galphaq was inhibited by mAChR antagonists, including scopolamine, ipratropium, atropine, 4-DAMP, pirenzepine, and AF-DX 116, with a rank order of potency consistent with previous studies of M1-expressing cells.	Carbachol	0-3	G protein subunit alpha q	Rattus norvegicus	43-50
24076274-7	2013	To confirm our results we performed in vitro experiments on live hippocampal slices: we evaluated whether stimulation of the cholinergic system with the cholinergic receptor agonist carbachol (CCh) activated the mTOR pathway and whether the administration of the above-mentioned antagonists together with CCh could revert this activation.	Carbachol	182-191	mechanistic target of rapamycin kinase	Rattus norvegicus	212-216
23371862-10	2013	Adult heterozygotes, which have a reduced expression of Nmnat2 at E18.5, showed decreased responses to carbachol and electrical stimulation compared to wild-type controls.	Carbachol	103-112	nicotinamide nucleotide adenylyltransferase 2	Mus musculus	56-62
24654541-7	2013	These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors.	Carbachol	47-56	Fas ligand	Rattus norvegicus	232-237
24654541-7	2013	These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors.	Carbachol	47-56	caspase 8	Rattus norvegicus	242-251
24654541-7	2013	These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors.	Carbachol	47-56	BCL2, apoptosis regulator	Rattus norvegicus	283-288
24654541-7	2013	These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors.	Carbachol	47-56	Bcl2-like 1	Rattus norvegicus	290-296
24654541-7	2013	These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors.	Carbachol	47-56	BCL2 associated X, apoptosis regulator	Rattus norvegicus	301-304
24654541-7	2013	These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors.	Carbachol	47-56	caspase 12	Rattus norvegicus	335-345
24654541-7	2013	These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors.	Carbachol	47-56	caspase 3	Rattus norvegicus	387-396
24654541-7	2013	These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors.	Carbachol	47-56	caspase 6	Rattus norvegicus	398-407
24654541-7	2013	These could be attenuated by pretreatment with carbachol and arecoline at the concentration of 10 micromol/L for 12 h. Homocysteine induced apoptosis in RAECs and the molecular mechanisms were associated with the regulation of fas, fas-L and caspase-8 in the death receptor pathway, bcl-2, bcl-xL and bax in the mitochondrial pathway, caspase-12 in the endoplasmic reticulum pathway and caspase-3, caspase-6 and p53 as downstream effectors.	Carbachol	47-56	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	412-415
23895769-6	2013	The best synchronized theta oscillations obtained after administration of 50 muM NMDA+50 muM BACL resembled theta activity induced by a bath perfusion of 50 muM carbachol.	Carbachol	161-170	latexin	Homo sapiens	77-80
24075004-0	2013	TRK-380, a novel selective human beta3-adrenoceptor agonist, ameliorates formalin-induced pollakiuria in rats and carbachol-induced bladder contraction in dogs.	Carbachol	114-123	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	0-3
24075004-8	2013	In dogs, CCh-induced bladder contraction was dose-dependently suppressed by TRK-380; the plasma concentration required for 30% suppression of the CCh-induced bladder contraction (30% relaxation) was 4.90 ng/mL.	Carbachol	9-12	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	76-79
24075004-8	2013	In dogs, CCh-induced bladder contraction was dose-dependently suppressed by TRK-380; the plasma concentration required for 30% suppression of the CCh-induced bladder contraction (30% relaxation) was 4.90 ng/mL.	Carbachol	146-149	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	76-79
24023725-14	2013	Interestingly, the MEK blocker did reduce carbachol-mediated cleaved caspase 3 expression in HEK293-M1 cells.	Carbachol	42-51	mitogen-activated protein kinase kinase 7	Homo sapiens	19-22
23895769-6	2013	The best synchronized theta oscillations obtained after administration of 50 muM NMDA+50 muM BACL resembled theta activity induced by a bath perfusion of 50 muM carbachol.	Carbachol	161-170	latexin	Homo sapiens	89-92
23895769-6	2013	The best synchronized theta oscillations obtained after administration of 50 muM NMDA+50 muM BACL resembled theta activity induced by a bath perfusion of 50 muM carbachol.	Carbachol	161-170	latexin	Homo sapiens	89-92
23784542-0	2013	Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes.	Carbachol	0-9	mucin 17, cell surface associated	Homo sapiens	18-23
24040112-9	2013	CFTR dependent currents following 18-24 hours of cold storage for forskolin/IBMX, carbachol, and forskolin/IBMX+carbachol stimulation (n=17 non-CF subjects) were 44%, 47.5%, and 47.3%, respectively of those in fresh biopsies.	Carbachol	82-91	CF transmembrane conductance regulator	Homo sapiens	0-4
24040112-9	2013	CFTR dependent currents following 18-24 hours of cold storage for forskolin/IBMX, carbachol, and forskolin/IBMX+carbachol stimulation (n=17 non-CF subjects) were 44%, 47.5%, and 47.3%, respectively of those in fresh biopsies.	Carbachol	112-121	CF transmembrane conductance regulator	Homo sapiens	0-4
23784542-0	2013	Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes.	Carbachol	0-9	solute carrier family 9 member A3	Homo sapiens	56-60
23784542-0	2013	Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes.	Carbachol	0-9	CF transmembrane conductance regulator	Homo sapiens	81-85
23784542-3	2013	Carbachol (CCh) stimulation of the small intestine results in gel-forming mucin secretion from goblet cells, something that requires adjacent enterocytes to secrete chloride and bicarbonate for proper mucin formation.	Carbachol	0-9	LOC100508689	Homo sapiens	74-79
23784542-3	2013	Carbachol (CCh) stimulation of the small intestine results in gel-forming mucin secretion from goblet cells, something that requires adjacent enterocytes to secrete chloride and bicarbonate for proper mucin formation.	Carbachol	0-9	LOC100508689	Homo sapiens	201-206
23784542-3	2013	Carbachol (CCh) stimulation of the small intestine results in gel-forming mucin secretion from goblet cells, something that requires adjacent enterocytes to secrete chloride and bicarbonate for proper mucin formation.	Carbachol	11-14	LOC100508689	Homo sapiens	74-79
23784542-3	2013	Carbachol (CCh) stimulation of the small intestine results in gel-forming mucin secretion from goblet cells, something that requires adjacent enterocytes to secrete chloride and bicarbonate for proper mucin formation.	Carbachol	11-14	LOC100508689	Homo sapiens	201-206
23784542-4	2013	Surface labeling and confocal imaging demonstrated that apically expressed MUC17 in Caco-2 cells and Muc3(17) in murine enterocytes were endocytosed upon stimulation with CCh.	Carbachol	171-174	mucin 17, cell surface associated	Homo sapiens	75-80
23784542-4	2013	Surface labeling and confocal imaging demonstrated that apically expressed MUC17 in Caco-2 cells and Muc3(17) in murine enterocytes were endocytosed upon stimulation with CCh.	Carbachol	171-174	MUC3	Homo sapiens	101-105
23784542-5	2013	Relocation of MUC17 in response to CCh was specific as MUC3 and MUC12 did not relocate following CCh stimulation.	Carbachol	35-38	mucin 17, cell surface associated	Homo sapiens	14-19
23784542-5	2013	Relocation of MUC17 in response to CCh was specific as MUC3 and MUC12 did not relocate following CCh stimulation.	Carbachol	35-38	MUC3	Homo sapiens	55-59
23784542-5	2013	Relocation of MUC17 in response to CCh was specific as MUC3 and MUC12 did not relocate following CCh stimulation.	Carbachol	35-38	mucin 12, cell surface associated	Homo sapiens	64-69
23784542-5	2013	Relocation of MUC17 in response to CCh was specific as MUC3 and MUC12 did not relocate following CCh stimulation.	Carbachol	97-100	mucin 17, cell surface associated	Homo sapiens	14-19
23784542-6	2013	MUC17 colocalized with PDZK1 under basal conditions, while MUC17 relocated to the terminal web and into early endosomes after CCh stimulation.	Carbachol	126-129	mucin 17, cell surface associated	Homo sapiens	59-64
23784542-7	2013	CCh stimulation concomitantly internalized the Na(+/)H(+) exchanger 3 (NHE3) and recruited cystic fibrosis transmembrane conductance regulator (CFTR) to the apical membranes, a process that was important for CFTR-mediated bicarbonate secretion necessary for proper gel-forming mucin unfolding.	Carbachol	0-3	solute carrier family 9 member A3	Homo sapiens	47-69
23784542-7	2013	CCh stimulation concomitantly internalized the Na(+/)H(+) exchanger 3 (NHE3) and recruited cystic fibrosis transmembrane conductance regulator (CFTR) to the apical membranes, a process that was important for CFTR-mediated bicarbonate secretion necessary for proper gel-forming mucin unfolding.	Carbachol	0-3	solute carrier family 9 member A3	Homo sapiens	71-75
23784542-7	2013	CCh stimulation concomitantly internalized the Na(+/)H(+) exchanger 3 (NHE3) and recruited cystic fibrosis transmembrane conductance regulator (CFTR) to the apical membranes, a process that was important for CFTR-mediated bicarbonate secretion necessary for proper gel-forming mucin unfolding.	Carbachol	0-3	CF transmembrane conductance regulator	Homo sapiens	91-142
23784542-7	2013	CCh stimulation concomitantly internalized the Na(+/)H(+) exchanger 3 (NHE3) and recruited cystic fibrosis transmembrane conductance regulator (CFTR) to the apical membranes, a process that was important for CFTR-mediated bicarbonate secretion necessary for proper gel-forming mucin unfolding.	Carbachol	0-3	CF transmembrane conductance regulator	Homo sapiens	144-148
23784542-7	2013	CCh stimulation concomitantly internalized the Na(+/)H(+) exchanger 3 (NHE3) and recruited cystic fibrosis transmembrane conductance regulator (CFTR) to the apical membranes, a process that was important for CFTR-mediated bicarbonate secretion necessary for proper gel-forming mucin unfolding.	Carbachol	0-3	CF transmembrane conductance regulator	Homo sapiens	208-212
23784542-7	2013	CCh stimulation concomitantly internalized the Na(+/)H(+) exchanger 3 (NHE3) and recruited cystic fibrosis transmembrane conductance regulator (CFTR) to the apical membranes, a process that was important for CFTR-mediated bicarbonate secretion necessary for proper gel-forming mucin unfolding.	Carbachol	0-3	LOC100508689	Homo sapiens	277-282
23816471-9	2013	Anti-beta-arrestin2 antibody partly blocked carbachol-induced increases of distal colonic strips in diabetic rats.	Carbachol	44-53	arrestin, beta 2, pseudogene	Rattus norvegicus	5-19
23703528-0	2013	PLC-gamma directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells.	Carbachol	65-74	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	35-40
23703528-0	2013	PLC-gamma directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells.	Carbachol	65-74	solute carrier family 9 member A3	Homo sapiens	98-102
23703528-5	2013	In Caco-2/BBe cells, carbachol (CCh) decreased NHE3 activity by ~40%, an effect abolished with the c-Src inhibitor PP2.	Carbachol	21-30	solute carrier family 9 member A3	Homo sapiens	47-51
23703528-5	2013	In Caco-2/BBe cells, carbachol (CCh) decreased NHE3 activity by ~40%, an effect abolished with the c-Src inhibitor PP2.	Carbachol	21-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	99-104
23703528-5	2013	In Caco-2/BBe cells, carbachol (CCh) decreased NHE3 activity by ~40%, an effect abolished with the c-Src inhibitor PP2.	Carbachol	21-30	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	115-118
23703528-5	2013	In Caco-2/BBe cells, carbachol (CCh) decreased NHE3 activity by ~40%, an effect abolished with the c-Src inhibitor PP2.	Carbachol	32-35	solute carrier family 9 member A3	Homo sapiens	47-51
23703528-5	2013	In Caco-2/BBe cells, carbachol (CCh) decreased NHE3 activity by ~40%, an effect abolished with the c-Src inhibitor PP2.	Carbachol	32-35	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	99-104
23703528-5	2013	In Caco-2/BBe cells, carbachol (CCh) decreased NHE3 activity by ~40%, an effect abolished with the c-Src inhibitor PP2.	Carbachol	32-35	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	115-118
23703528-6	2013	CCh treatment increased the amount of active c-Src as early as 1 min through increased Y(416) phosphorylation.	Carbachol	0-3	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	45-50
23884641-6	2013	Functionally, the contractile EBs displayed calcium cycling and were responsive to the chronotropic agents isoprenaline (0.1 muM) and carbachol (1 muM).	Carbachol	134-143	latexin	Homo sapiens	147-150
23784544-6	2013	Carbachol (CCh) stimulated phosphatidylinositol (PI) hydrolysis, Rho kinase and zipper-interacting protein (ZIP) kinase activity, induced myosin phosphatase 1 (MYPT1) phosphorylation (at Thr(696)) and 20-kDa myosin light chain (MLC20) phosphorylation (at Ser(19)) and muscle contraction, and inhibited cAMP formation.	Carbachol	0-9	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	65-75
23703528-7	2013	Coimmunoprecipitation demonstrated that c-Src associated with PLC-gamma, but not NHE3, under basal conditions, an interaction that increased rapidly after CCh treatment and occurred before the dissociation of PLC-gamma and NHE3 that occurred 10 min after CCh treatment.	Carbachol	155-158	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-45
23703528-7	2013	Coimmunoprecipitation demonstrated that c-Src associated with PLC-gamma, but not NHE3, under basal conditions, an interaction that increased rapidly after CCh treatment and occurred before the dissociation of PLC-gamma and NHE3 that occurred 10 min after CCh treatment.	Carbachol	255-258	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-45
23703528-9	2013	This study demonstrated that c-Src 1) activity is necessary for [Ca(2+)]i inhibition of NHE3 activity, 2) activation occurs rapidly (~1 min) after CCh treatment, 3) directly binds PLC-gamma SH2 domains and associates dynamically with PLC-gamma under elevated [Ca(2+)]i conditions, and 4) does not directly bind NHE3.	Carbachol	147-150	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	29-34
23703528-9	2013	This study demonstrated that c-Src 1) activity is necessary for [Ca(2+)]i inhibition of NHE3 activity, 2) activation occurs rapidly (~1 min) after CCh treatment, 3) directly binds PLC-gamma SH2 domains and associates dynamically with PLC-gamma under elevated [Ca(2+)]i conditions, and 4) does not directly bind NHE3.	Carbachol	147-150	solute carrier family 9 member A3	Homo sapiens	88-92
23784544-6	2013	Carbachol (CCh) stimulated phosphatidylinositol (PI) hydrolysis, Rho kinase and zipper-interacting protein (ZIP) kinase activity, induced myosin phosphatase 1 (MYPT1) phosphorylation (at Thr(696)) and 20-kDa myosin light chain (MLC20) phosphorylation (at Ser(19)) and muscle contraction, and inhibited cAMP formation.	Carbachol	0-9	protein phosphatase 1, regulatory subunit 12A	Mus musculus	138-158
23784544-7	2013	Stimulation of PI hydrolysis, Rho kinase, and ZIP kinase activity, phosphorylation of MYPT1 and MLC20, and muscle contraction in response to CCh were attenuated by methyl beta-cyclodextrin (MbetaCD) or caveolin-1 small interfering RNA (siRNA).	Carbachol	141-144	protein phosphatase 1, regulatory subunit 12A	Mus musculus	86-91
23784544-6	2013	Carbachol (CCh) stimulated phosphatidylinositol (PI) hydrolysis, Rho kinase and zipper-interacting protein (ZIP) kinase activity, induced myosin phosphatase 1 (MYPT1) phosphorylation (at Thr(696)) and 20-kDa myosin light chain (MLC20) phosphorylation (at Ser(19)) and muscle contraction, and inhibited cAMP formation.	Carbachol	0-9	protein phosphatase 1, regulatory subunit 12A	Mus musculus	160-165
23784544-6	2013	Carbachol (CCh) stimulated phosphatidylinositol (PI) hydrolysis, Rho kinase and zipper-interacting protein (ZIP) kinase activity, induced myosin phosphatase 1 (MYPT1) phosphorylation (at Thr(696)) and 20-kDa myosin light chain (MLC20) phosphorylation (at Ser(19)) and muscle contraction, and inhibited cAMP formation.	Carbachol	0-9	myosin, light polypeptide 9, regulatory	Mus musculus	228-233
23784544-7	2013	Stimulation of PI hydrolysis, Rho kinase, and ZIP kinase activity, phosphorylation of MYPT1 and MLC20, and muscle contraction in response to CCh were attenuated by methyl beta-cyclodextrin (MbetaCD) or caveolin-1 small interfering RNA (siRNA).	Carbachol	141-144	myosin, light polypeptide 9, regulatory	Mus musculus	96-101
23784544-7	2013	Stimulation of PI hydrolysis, Rho kinase, and ZIP kinase activity, phosphorylation of MYPT1 and MLC20, and muscle contraction in response to CCh were attenuated by methyl beta-cyclodextrin (MbetaCD) or caveolin-1 small interfering RNA (siRNA).	Carbachol	141-144	caveolin 1, caveolae protein	Mus musculus	202-212
23784544-8	2013	Similar inhibition of PI hydrolysis, Rho kinase, and ZIP kinase activity and muscle contraction in response to CCh and gastric emptying in vivo was obtained in caveolin-1-knockout mice compared with wild-type mice.	Carbachol	111-114	death-associated protein kinase 3	Mus musculus	53-63
23784544-8	2013	Similar inhibition of PI hydrolysis, Rho kinase, and ZIP kinase activity and muscle contraction in response to CCh and gastric emptying in vivo was obtained in caveolin-1-knockout mice compared with wild-type mice.	Carbachol	111-114	caveolin 1, caveolae protein	Mus musculus	160-170
23786223-5	2013	The carbachol response was unaffected in the M2KO strain but decreased 42% in M3KO mice (p &lt; 0.01).	Carbachol	4-13	cholinergic receptor, muscarinic 3, cardiac	Mus musculus	78-82
23475395-0	2013	Histamine, carbachol, and serotonin induce hyperresponsiveness to ATP in guinea pig tracheas: involvement of COX-2 pathway.	Carbachol	11-20	cytochrome c oxidase subunit II	Cavia porcellus	109-114
23475395-8	2013	Airway epithelial cells showed increased COX-2 mRNA after stimulation with histamine or carbachol, but not serotonin, while COX-1 mRNA was unaffected.	Carbachol	88-97	cytochrome c oxidase subunit II	Cavia porcellus	41-46
23475395-10	2013	In conclusion, we showed for the first time that histamine and carbachol cause hyperresponsiveness to ATP by upregulating COX-2 in airway epithelium, which likely increases TXA2 production.	Carbachol	63-72	cytochrome c oxidase subunit II	Cavia porcellus	122-127
23361868-7	2013	Carbamylcholine chloride, a parasympathomimetic drug, equally effectively reduced the heart rates of wild-type and EAAT3 knockout mice.	Carbachol	0-24	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	Mus musculus	115-120
23784544-6	2013	Carbachol (CCh) stimulated phosphatidylinositol (PI) hydrolysis, Rho kinase and zipper-interacting protein (ZIP) kinase activity, induced myosin phosphatase 1 (MYPT1) phosphorylation (at Thr(696)) and 20-kDa myosin light chain (MLC20) phosphorylation (at Ser(19)) and muscle contraction, and inhibited cAMP formation.	Carbachol	11-14	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	65-75
23784544-6	2013	Carbachol (CCh) stimulated phosphatidylinositol (PI) hydrolysis, Rho kinase and zipper-interacting protein (ZIP) kinase activity, induced myosin phosphatase 1 (MYPT1) phosphorylation (at Thr(696)) and 20-kDa myosin light chain (MLC20) phosphorylation (at Ser(19)) and muscle contraction, and inhibited cAMP formation.	Carbachol	11-14	protein phosphatase 1, regulatory subunit 12A	Mus musculus	138-158
23784544-6	2013	Carbachol (CCh) stimulated phosphatidylinositol (PI) hydrolysis, Rho kinase and zipper-interacting protein (ZIP) kinase activity, induced myosin phosphatase 1 (MYPT1) phosphorylation (at Thr(696)) and 20-kDa myosin light chain (MLC20) phosphorylation (at Ser(19)) and muscle contraction, and inhibited cAMP formation.	Carbachol	11-14	protein phosphatase 1, regulatory subunit 12A	Mus musculus	160-165
23784544-6	2013	Carbachol (CCh) stimulated phosphatidylinositol (PI) hydrolysis, Rho kinase and zipper-interacting protein (ZIP) kinase activity, induced myosin phosphatase 1 (MYPT1) phosphorylation (at Thr(696)) and 20-kDa myosin light chain (MLC20) phosphorylation (at Ser(19)) and muscle contraction, and inhibited cAMP formation.	Carbachol	11-14	myosin, light polypeptide 9, regulatory	Mus musculus	228-233
23760269-4	2013	In cells expressing the M3 muscarinic acetylcholine receptor, the agonist carbachol (Cch) caused strong activation of CFTR through two pathways; the canonical PKA-dependent mechanism and a second mechanism that involves tyrosine phosphorylation.	Carbachol	74-83	cystic fibrosis transmembrane conductance regulator	Mesocricetus auratus	118-122
23760269-4	2013	In cells expressing the M3 muscarinic acetylcholine receptor, the agonist carbachol (Cch) caused strong activation of CFTR through two pathways; the canonical PKA-dependent mechanism and a second mechanism that involves tyrosine phosphorylation.	Carbachol	85-88	cystic fibrosis transmembrane conductance regulator	Mesocricetus auratus	118-122
23760269-6	2013	The role of tyrosine kinases was suggested by Cch stimulation of 15SA-CFTR and 9CA-CFTR, mutants that lack 15 PKA or 9 PKC consensus sequences and are unresponsive to PKA or PKC stimulation, respectively.	Carbachol	46-49	cystic fibrosis transmembrane conductance regulator	Mesocricetus auratus	70-74
23760269-6	2013	The role of tyrosine kinases was suggested by Cch stimulation of 15SA-CFTR and 9CA-CFTR, mutants that lack 15 PKA or 9 PKC consensus sequences and are unresponsive to PKA or PKC stimulation, respectively.	Carbachol	46-49	cystic fibrosis transmembrane conductance regulator	Mesocricetus auratus	83-87
23894286-4	2013	Using phage display screening, we have previously identified a heptapeptide, termed IQ, homologous to most nAChR subtypes, binding with nanomolar affinity to soluble Abeta40 and blocking Abeta-induced inhibition of carbamylcholine-induced currents in PC12 cells expressing alpha7 nAChRs.	Carbachol	215-230	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	107-112
23727356-8	2013	In CHO-M1 cells, M1-mAChR activation by carbachol resulted in Ca(2+) mobilization, ERK1/2 phosphorylation and a reduction in thymidine incorporation, all of which were completely inhibited by MT-7, indicating the involvement of surface M1-mAChRs.	Carbachol	40-49	mitogen-activated protein kinase 3	Mus musculus	83-89
23732791-1	2013	Through microfluidic interrogation we analyzed real-time calcium responses of HEK293 cells stimulated with short pulses of the M3 muscarinic receptor ligand carbachol in two different concentration regimes.	Carbachol	157-166	cholinergic receptor muscarinic 3	Homo sapiens	127-149
23583240-11	2013	RGS4 knockout mice showed significantly enhanced sensitivity to AF induction in the presence of carbachol.	Carbachol	96-105	regulator of G-protein signaling 4	Mus musculus	0-4
23639814-7	2013	As opposed to the lack of strain differences in the U46619-induced force, the newborn hph-1 gastric muscle carbachol-induced contraction and nNOS-dependent relaxation were significantly reduced (P &lt; 0.01).	Carbachol	107-116	hyperphenylalaninemia 1	Mus musculus	86-91
23685950-7	2013	Pretreatment with carbachol (0.01 mumol/L) blocked glutamate-induced cell death and GSK-3beta overactivation, and markedly enhanced beta-catenin transcriptional activity.	Carbachol	18-27	glycogen synthase kinase 3 beta	Rattus norvegicus	84-93
23685950-7	2013	Pretreatment with carbachol (0.01 mumol/L) blocked glutamate-induced cell death and GSK-3beta overactivation, and markedly enhanced beta-catenin transcriptional activity.	Carbachol	18-27	catenin beta 1	Rattus norvegicus	132-144
23826977-6	2013	Strips of denuded detrusor or mucosa were mounted in organ baths to study the effect of TRPM8 agonists on the contractile responses to 10 mumol/L carbachol.	Carbachol	146-155	transient receptor potential cation channel subfamily M member 8	Sus scrofa	88-93
23721928-6	2013	In both exposed and control animals, 100 muM carbachol had a transient excitatory effect on spontaneous activity followed by a rapid weakening of activity to near or below normal levels.	Carbachol	45-54	latexin	Homo sapiens	41-44
23613531-4	2013	CCh increased MYPT1 phosphorylation at Thr696 (pT696) and Thr853 (pT853), CPI-17 at Thr38 (pT38), and myosin light chain at Ser19 (pS19).	Carbachol	0-3	protein phosphatase 1, regulatory subunit 12A	Mus musculus	14-19
23613531-4	2013	CCh increased MYPT1 phosphorylation at Thr696 (pT696) and Thr853 (pT853), CPI-17 at Thr38 (pT38), and myosin light chain at Ser19 (pS19).	Carbachol	0-3	protein phosphatase 1, regulatory inhibitor subunit 14A	Mus musculus	74-80
23613531-12	2013	Bath-applied CCh recruits additional ROCK-dependent MYPT1 phosphorylation due to exposure of the agonist to a wider population of muscarinic receptors.	Carbachol	13-16	protein phosphatase 1, regulatory subunit 12A	Mus musculus	52-57
23529130-2	2013	Induction of currents (ICCh) in TRPC6-expressing HEK293 cells by a muscarinic agonist carbachol (CCh; 100 mum) was strongly attenuated by a CaMKII-specific peptide, autocamtide-2-related inhibitory peptide (AIP; 10 mum).	Carbachol	86-95	transient receptor potential cation channel subfamily C member 6	Homo sapiens	32-37
23651161-5	2013	In this study, using in vitro whole-cell patch-clamp recordings in a rat hippocampal slice preparation, we show that hippocampal CA3 pyramidal cells support persistent firing under perfusion of the cholinergic agonist carbachol (10 mum).	Carbachol	218-227	carbonic anhydrase 3	Rattus norvegicus	129-132
23529130-2	2013	Induction of currents (ICCh) in TRPC6-expressing HEK293 cells by a muscarinic agonist carbachol (CCh; 100 mum) was strongly attenuated by a CaMKII-specific peptide, autocamtide-2-related inhibitory peptide (AIP; 10 mum).	Carbachol	24-27	transient receptor potential cation channel subfamily C member 6	Homo sapiens	32-37
23529130-2	2013	Induction of currents (ICCh) in TRPC6-expressing HEK293 cells by a muscarinic agonist carbachol (CCh; 100 mum) was strongly attenuated by a CaMKII-specific peptide, autocamtide-2-related inhibitory peptide (AIP; 10 mum).	Carbachol	86-95	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	140-146
23529130-2	2013	Induction of currents (ICCh) in TRPC6-expressing HEK293 cells by a muscarinic agonist carbachol (CCh; 100 mum) was strongly attenuated by a CaMKII-specific peptide, autocamtide-2-related inhibitory peptide (AIP; 10 mum).	Carbachol	24-27	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	140-146
23608222-8	2013	Substantial glucose-induced insulin secretion was induced in the pancreas perfusion study of Kir6.2(-/-) mice only in the presence of carbamylcholine.	Carbachol	134-149	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	93-99
23525004-1	2013	Cholesterol depletion reversibly abolishes carbachol-evoked Ca(2+) release from inositol (1,4,5)-trisphosphate (IP3)-sensitive stores, without affecting the distribution of IP3 receptors (IP3R) or endoplasmic reticulum, IP3 formation or responses to photolysis of caged IP3.	Carbachol	43-52	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	188-192
23546599-8	2013	In organ bath study using bladder strips, the PTHrP peptide caused a marked reduction in the amplitude of spontaneous contraction but caused only modest suppression for carbachol-induced contraction.	Carbachol	169-178	parathyroid hormone-like hormone	Rattus norvegicus	46-51
23513060-4	2013	RESULTS: Exposure to IL-6 at concentrations of 1 and 10 ng/mL and IL-1beta at 10 ng/mL significantly decreased CCh-induced Cl(-) secretion.	Carbachol	111-114	interleukin 6	Homo sapiens	21-25
23353793-0	2013	Involvement of the Tyr kinase/JNK pathway in carbachol-induced bronchial smooth muscle contraction in the rat.	Carbachol	45-54	mitogen-activated protein kinase 8	Rattus norvegicus	30-33
23353793-7	2013	The contraction induced by carbachol (CCh) was significantly inhibited by pretreatment with selective Tyr kinase inhibitors (genistein and ST638, n = 6, respectively), and a JNK inhibitor (SP600125, n = 6).	Carbachol	27-36	mitogen-activated protein kinase 8	Rattus norvegicus	174-177
23353793-7	2013	The contraction induced by carbachol (CCh) was significantly inhibited by pretreatment with selective Tyr kinase inhibitors (genistein and ST638, n = 6, respectively), and a JNK inhibitor (SP600125, n = 6).	Carbachol	38-41	mitogen-activated protein kinase 8	Rattus norvegicus	174-177
23353793-11	2013	The JNK phosphorylation induced by CCh was significantly inhibited by SP600125 (n = 4).	Carbachol	35-38	mitogen-activated protein kinase 8	Rattus norvegicus	4-7
23945308-9	2013	With 20 mmol/L caffeine and 100 micromol/L carbachol which stimulated Ca2+ release respectively from internal ryanodine receptor (RYR) and inositol triphosphate (IP3) Ca2+ storage, the fluorescence intensity F/F0 curve presented a peak pattern.	Carbachol	43-52	ryanodine receptor 2	Rattus norvegicus	130-133
23513060-4	2013	RESULTS: Exposure to IL-6 at concentrations of 1 and 10 ng/mL and IL-1beta at 10 ng/mL significantly decreased CCh-induced Cl(-) secretion.	Carbachol	111-114	interleukin 1 beta	Homo sapiens	66-74
23513060-6	2013	CCh, 10 muM, prevented CCh, 100 muM, from eliciting Cl(-) secretion.	Carbachol	0-3	latexin	Homo sapiens	8-11
23339174-9	2013	Carbachol-stimulated acid secretion was higher in GFRalpha2-KO mice, while atropine reduced basal secretion similarly in both genotypes.	Carbachol	0-9	glial cell line derived neurotrophic factor family receptor alpha 2	Mus musculus	50-59
23513060-6	2013	CCh, 10 muM, prevented CCh, 100 muM, from eliciting Cl(-) secretion.	Carbachol	0-3	latexin	Homo sapiens	32-35
23513060-6	2013	CCh, 10 muM, prevented CCh, 100 muM, from eliciting Cl(-) secretion.	Carbachol	23-26	latexin	Homo sapiens	8-11
23513060-6	2013	CCh, 10 muM, prevented CCh, 100 muM, from eliciting Cl(-) secretion.	Carbachol	23-26	latexin	Homo sapiens	32-35
22022845-4	2013	RESULTS: Carbachol (CCh), an analog of acetylcholine (ACh) significantly enhanced de novo differentiation into neurons on bFGF- and EGF-deprived stem cells as shown by the percentage of TUJ1 positive cells.	Carbachol	9-18	fibroblast growth factor 2	Mus musculus	122-126
23365260-6	2013	Although carbachol (CCh)-induced (0.1-100 microM) time- and dose-dependent contractions in Adip-Sen mouse bladder were slightly enhanced, compared with those in the C57Bl mouse during a low range (0.3-1.0 microM) of CCh, differences could not be detected with other CCh concentrations.	Carbachol	9-18	synovial sarcoma, X 2 interacting protein	Mus musculus	91-95
23365260-6	2013	Although carbachol (CCh)-induced (0.1-100 microM) time- and dose-dependent contractions in Adip-Sen mouse bladder were slightly enhanced, compared with those in the C57Bl mouse during a low range (0.3-1.0 microM) of CCh, differences could not be detected with other CCh concentrations.	Carbachol	20-23	synovial sarcoma, X 2 interacting protein	Mus musculus	91-95
23365260-6	2013	Although carbachol (CCh)-induced (0.1-100 microM) time- and dose-dependent contractions in Adip-Sen mouse bladder were slightly enhanced, compared with those in the C57Bl mouse during a low range (0.3-1.0 microM) of CCh, differences could not be detected with other CCh concentrations.	Carbachol	216-219	synovial sarcoma, X 2 interacting protein	Mus musculus	91-95
23365260-6	2013	Although carbachol (CCh)-induced (0.1-100 microM) time- and dose-dependent contractions in Adip-Sen mouse bladder were slightly enhanced, compared with those in the C57Bl mouse during a low range (0.3-1.0 microM) of CCh, differences could not be detected with other CCh concentrations.	Carbachol	216-219	synovial sarcoma, X 2 interacting protein	Mus musculus	91-95
23365260-10	2013	Expression of the calcium-dependent isoform of PKC, PKCalpha, was increased in the Adip-Sen mouse bladder, and CCh-induced phosphorylation of PKCalpha was also enhanced, compared with those in the C57Bl mouse.	Carbachol	111-114	protein kinase C, alpha	Mus musculus	47-50
23365260-10	2013	Expression of the calcium-dependent isoform of PKC, PKCalpha, was increased in the Adip-Sen mouse bladder, and CCh-induced phosphorylation of PKCalpha was also enhanced, compared with those in the C57Bl mouse.	Carbachol	111-114	synovial sarcoma, X 2 interacting protein	Mus musculus	83-87
23365260-10	2013	Expression of the calcium-dependent isoform of PKC, PKCalpha, was increased in the Adip-Sen mouse bladder, and CCh-induced phosphorylation of PKCalpha was also enhanced, compared with those in the C57Bl mouse.	Carbachol	111-114	protein kinase C, alpha	Mus musculus	142-150
22022845-4	2013	RESULTS: Carbachol (CCh), an analog of acetylcholine (ACh) significantly enhanced de novo differentiation into neurons on bFGF- and EGF-deprived stem cells as shown by the percentage of TUJ1 positive cells.	Carbachol	20-23	fibroblast growth factor 2	Mus musculus	122-126
23047022-7	2013	Cellular release of AChE by SH-SY5Y is significantly enhanced by the muscarinic acetylcholine receptor (mAChR) agonists carbachol or muscarine, with the effect of carbachol blocked by the mAChR antagonist atropine.	Carbachol	120-129	acetylcholinesterase	Mus musculus	20-24
23047022-7	2013	Cellular release of AChE by SH-SY5Y is significantly enhanced by the muscarinic acetylcholine receptor (mAChR) agonists carbachol or muscarine, with the effect of carbachol blocked by the mAChR antagonist atropine.	Carbachol	163-172	acetylcholinesterase	Mus musculus	20-24
23292809-4	2013	We found that the muscarinic agonists, carbachol (CCh) and oxotremorine, activated ENaC in a dose-dependent manner but that nicotine did not.	Carbachol	39-48	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	83-87
23292809-4	2013	We found that the muscarinic agonists, carbachol (CCh) and oxotremorine, activated ENaC in a dose-dependent manner but that nicotine did not.	Carbachol	50-53	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	83-87
23292809-5	2013	CCh-induced activation of ENaC was blocked by atropine.	Carbachol	0-3	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	26-30
23292809-7	2013	Endogenous RhoA and GTP-RhoA increased in response to CCh and the increase was reduced by pretreatment with atropine.	Carbachol	54-57	ras homolog family member A	Rattus norvegicus	11-15
23292809-7	2013	Endogenous RhoA and GTP-RhoA increased in response to CCh and the increase was reduced by pretreatment with atropine.	Carbachol	54-57	ras homolog family member A	Rattus norvegicus	24-28
23292809-8	2013	We showed that Y-27632, an inhibitor of Rho-associated protein kinase (ROCK), abolished endogenous ENaC activity and inhibited the activation of ENaC by CCh.	Carbachol	153-156	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	145-149
23362260-4	2013	Phosphorylation of the myosin light chain phosphatase regulatory subunit MYPT1 at Thr-696 and Thr-853 and the inhibitor protein CPI-17 were also stimulated with carbachol.	Carbachol	161-170	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	73-78
23362260-4	2013	Phosphorylation of the myosin light chain phosphatase regulatory subunit MYPT1 at Thr-696 and Thr-853 and the inhibitor protein CPI-17 were also stimulated with carbachol.	Carbachol	161-170	protein phosphatase 1 regulatory inhibitor subunit 14A	Homo sapiens	128-134
23275618-6	2013	Both OA and Epac ligand stimulated Ras-related protein 1 (Rap1) and inhibited carbachol (CCh)-induced Rho kinase activity.	Carbachol	78-87	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	12-16
23275618-6	2013	Both OA and Epac ligand stimulated Ras-related protein 1 (Rap1) and inhibited carbachol (CCh)-induced Rho kinase activity.	Carbachol	89-92	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	12-16
22865467-3	2012	The inhibition of the epidermal growth factor receptor (EGFR) by AG1478 or protein kinase C (PKC) by GF109203X significantly reduced carbachol-stimulated ERK1/2 activation and cell proliferation.	Carbachol	133-142	epidermal growth factor receptor	Homo sapiens	22-54
23007238-8	2013	RESULTS: T1N0Mx-IgG promoted tumor cell migration and increased MMP9 activity mimicking the action of the muscarinic agonist carbachol.	Carbachol	125-134	matrix metallopeptidase 9	Homo sapiens	64-68
23246623-5	2013	Detrusor contractility was evaluated by organ bath studies and strips were incubated with carbachol (1muM) to induce and enhance tension.	Carbachol	90-99	latexin	Homo sapiens	102-105
23095462-8	2013	Relaxation to CCh was reduced in TRPC1 KO and TRPC3 KO aortas with concomitant reduction in EC Ca(2+) response.	Carbachol	14-17	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	33-38
23095462-8	2013	Relaxation to CCh was reduced in TRPC1 KO and TRPC3 KO aortas with concomitant reduction in EC Ca(2+) response.	Carbachol	14-17	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	46-51
23095462-9	2013	Pyr3 (TRPC3 blocker) reduced the Ca(2+) response to CCh in EC from WT, but not TRPC3 KO mice.	Carbachol	52-55	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	6-11
23090691-4	2013	Coprecipitating Gbeta with Kir3.1, detected by Western blotting, was significantly augmented by carbachol.	Carbachol	96-105	potassium inwardly-rectifying channel, subfamily J, member 3	Mus musculus	27-33
23090691-5	2013	Atropine, but not tertiapin, significantly inhibited the carbachol-induced coprecipitating Gbeta with Kir3.1.	Carbachol	57-66	potassium inwardly-rectifying channel, subfamily J, member 3	Mus musculus	102-108
23520542-6	2013	Voltage-clamp experiments using ramped voltage commands showed that CCh resulted in the gradual development of an inward current that was partially blocked by concurrent application of the selective Kv7.2/3 channel antagonist XE-991, which inhibits the muscarine-dependent K(+) current I M. The remaining inward current also reversed near EK and was inhibited by the K(+) channel blocker Ba(2+), suggesting that M1 receptor activation attenuates both I M as well as an additional K(+) current.	Carbachol	68-71	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	199-206
23460876-7	2013	We demonstrated that T1N0Mx-IgG (10(-8) M) and carbachol (10(-9) M) increased the constitutive expression of VEGF-A in tumor cells, effect that was reverted by the muscarinic antagonist atropine.	Carbachol	47-56	vascular endothelial growth factor A	Homo sapiens	109-115
23460876-10	2013	In conclusion, T1N0Mx-IgG and carbachol may promote VEGF-A production and neovascularization induced by breast tumor cells via muscarinic receptors activation.	Carbachol	30-39	vascular endothelial growth factor A	Homo sapiens	52-58
23469045-3	2013	In combination with carbachol (10 microM), rivastigmine (1 microM) significantly decreased the release of nitric oxide, TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-activated RAW 264.7 macrophages and this effect was abolished by alpha7 nicotinic receptor blockade by bungarotoxin.	Carbachol	20-29	tumor necrosis factor	Rattus norvegicus	120-129
23469045-3	2013	In combination with carbachol (10 microM), rivastigmine (1 microM) significantly decreased the release of nitric oxide, TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-activated RAW 264.7 macrophages and this effect was abolished by alpha7 nicotinic receptor blockade by bungarotoxin.	Carbachol	20-29	interleukin 1 beta	Rattus norvegicus	131-139
23469045-3	2013	In combination with carbachol (10 microM), rivastigmine (1 microM) significantly decreased the release of nitric oxide, TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-activated RAW 264.7 macrophages and this effect was abolished by alpha7 nicotinic receptor blockade by bungarotoxin.	Carbachol	20-29	interleukin 6	Rattus norvegicus	144-148
23382834-5	2013	HSG-hAQP5 pre-incubated with SjS plasma for 24 hours significantly reduced AQP5 trafficking with CCh, compared with HSG-hAQP5 pre-incubated with healthy control (HC) plasma.	Carbachol	97-100	aquaporin 5	Homo sapiens	4-9
23382834-5	2013	HSG-hAQP5 pre-incubated with SjS plasma for 24 hours significantly reduced AQP5 trafficking with CCh, compared with HSG-hAQP5 pre-incubated with healthy control (HC) plasma.	Carbachol	97-100	aquaporin 5	Homo sapiens	5-9
22902499-5	2012	KEY FINDINGS: Both nAChR and mAChR antagonists (hexamethonium and methacine, respectively), per se, elevated histamine-releasing activity of the HMC-1 and suppressed the MC responses to most of investigated activators (carbachol, compound 48/80, and to a lesser extent aIgG).	Carbachol	219-228	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	19-24
23098909-7	2012	Carbachol exerts its beneficial effect on the amelioration of the TJ damage by inhibiting the NF-kappabeta and MLCK pathways in an alpha7nAchR-dependent manner.	Carbachol	0-9	myosin light chain kinase	Rattus norvegicus	111-115
23397206-10	2013	A carbachol-induced increase in the cytosolic Ca(2+) concentration was significantly reduced when cells were pretreated with siRNA against STIM1.	Carbachol	2-11	stromal interaction molecule 1	Rattus norvegicus	139-144
23431067-7	2013	Tyrosine phosphorylation of heterologously expressed NCKX2-WT, but not NCKX2-Y365A, was increased by carbachol (CCh) in PC-12 cells.	Carbachol	101-110	solute carrier family 24 member 2	Rattus norvegicus	53-58
23431067-7	2013	Tyrosine phosphorylation of heterologously expressed NCKX2-WT, but not NCKX2-Y365A, was increased by carbachol (CCh) in PC-12 cells.	Carbachol	112-115	solute carrier family 24 member 2	Rattus norvegicus	53-58
23122879-4	2013	The retrograde tracer cholera toxin subunit b (CTb) was administered in pontine regions where carbachol microinjections induced REM sleep.	Carbachol	94-103	phosphate cytidylyltransferase 1B, choline	Homo sapiens	22-45
23122879-4	2013	The retrograde tracer cholera toxin subunit b (CTb) was administered in pontine regions where carbachol microinjections induced REM sleep.	Carbachol	94-103	phosphate cytidylyltransferase 1B, choline	Homo sapiens	47-50
23135699-3	2013	Switching from SMB to SMA MHC protein expression decreased the rate of the force transient and increased the sustained tonic force in SMB((-/-)) ileum and antrum with high potassium (KPSS) but not with carbachol (CCh) stimulation.	Carbachol	213-216	immunoglobulin mu binding protein 2	Mus musculus	22-25
23135699-6	2013	However, specifically activating PKCalpha with phorbol dibutyrate (PDBu) was not significantly different in knockout and wild-type tissues, with total force being a fraction of the force generation with KPSS or CCh stimulation in SMB((-/-)) ileum and antrum.	Carbachol	211-214	small nuclear ribonucleoprotein B	Mus musculus	230-233
23246623-0	2013	The novel beta3-adrenoceptor agonist mirabegron reduces carbachol-induced contractile activity in detrusor tissue from patients with bladder outflow obstruction with or without detrusor overactivity.	Carbachol	56-65	adrenoceptor beta 3	Homo sapiens	10-28
23022458-7	2013	Furthermore, moderate treatment of Slc10a4 null slices with the cholinergic agonist carbachol induced epileptiform activity.	Carbachol	84-93	solute carrier family 10 (sodium/bile acid cotransporter family), member 4	Mus musculus	35-42
22861176-5	2013	When evaluated for inhibition of the carbachol-induced contraction of rat urinary bladder, 5-HMT MS showed a much longer and more potent effect than tolterodine tablets.	Carbachol	37-46	histamine N-methyltransferase	Rattus norvegicus	93-96
23098909-0	2012	Carbachol ameliorates lipopolysaccharide-induced intestinal epithelial tight junction damage by down-regulating NF-kappabeta and myosin light-chain kinase pathways.	Carbachol	0-9	myosin light chain kinase	Rattus norvegicus	129-154
22906005-3	2012	A double phosphorylation-deficient mutant (S490/543A) of AC2 was insensitive to PMA (phorbol myristic acid) and CCh (carbachol) stimulation, whereas a double phosphomimetic mutant (S490/543D) mimicked the activity of PKC-activated AC2.	Carbachol	112-115	adenylate cyclase 2	Homo sapiens	57-60
22906005-3	2012	A double phosphorylation-deficient mutant (S490/543A) of AC2 was insensitive to PMA (phorbol myristic acid) and CCh (carbachol) stimulation, whereas a double phosphomimetic mutant (S490/543D) mimicked the activity of PKC-activated AC2.	Carbachol	117-126	adenylate cyclase 2	Homo sapiens	57-60
22865467-3	2012	The inhibition of the epidermal growth factor receptor (EGFR) by AG1478 or protein kinase C (PKC) by GF109203X significantly reduced carbachol-stimulated ERK1/2 activation and cell proliferation.	Carbachol	133-142	epidermal growth factor receptor	Homo sapiens	56-60
22865467-3	2012	The inhibition of the epidermal growth factor receptor (EGFR) by AG1478 or protein kinase C (PKC) by GF109203X significantly reduced carbachol-stimulated ERK1/2 activation and cell proliferation.	Carbachol	133-142	mitogen-activated protein kinase 3	Homo sapiens	154-160
22865467-4	2012	Cotreatment of the cells with AG1478 and GF109203X produced an additive effect on carbachol-stimulated ERK1/2 activation, suggesting that the EGFR and PKC pathways act in parallel.	Carbachol	82-91	mitogen-activated protein kinase 3	Homo sapiens	103-109
22865467-4	2012	Cotreatment of the cells with AG1478 and GF109203X produced an additive effect on carbachol-stimulated ERK1/2 activation, suggesting that the EGFR and PKC pathways act in parallel.	Carbachol	82-91	epidermal growth factor receptor	Homo sapiens	142-146
22865467-6	2012	In SNU-407 cells, carbachol treatment induced RSK activation in an atropine-sensitive manner, and this RSK activation was decreased by the inhibition of either EGFR or PKC.	Carbachol	18-27	ribosomal protein S6 kinase A1	Homo sapiens	46-49
22865467-6	2012	In SNU-407 cells, carbachol treatment induced RSK activation in an atropine-sensitive manner, and this RSK activation was decreased by the inhibition of either EGFR or PKC.	Carbachol	18-27	ribosomal protein S6 kinase A1	Homo sapiens	103-106
22865467-6	2012	In SNU-407 cells, carbachol treatment induced RSK activation in an atropine-sensitive manner, and this RSK activation was decreased by the inhibition of either EGFR or PKC.	Carbachol	18-27	epidermal growth factor receptor	Homo sapiens	160-164
22865467-7	2012	Moreover, the RSK-specific inhibitor BRD7389 almost completely blocked carbachol-stimulated cell proliferation.	Carbachol	71-80	ribosomal protein S6 kinase A1	Homo sapiens	14-17
22936272-8	2012	Both cAMP and carbachol recruited NKCC1 to the basolateral membrane of enterocytes, while luminal acid or HCO(3)(-) retained NKCC1 in intracellular vesicles.	Carbachol	14-23	solute carrier family 12 member 2	Rattus norvegicus	34-39
22814700-3	2012	In addition, the effect of colitis on the possible involvement of NCX-1 in the reduced carbachol-induced contraction of the rat colon was examined.	Carbachol	87-96	solute carrier family 8 member A1	Rattus norvegicus	66-71
22814700-13	2012	Functional experiments demonstrated that NCX in reverse mode played a role in carbachol-induced contraction of colon, and this was not affected by colitis.	Carbachol	78-87	solute carrier family 8 member A1	Rattus norvegicus	41-44
23077334-8	2012	Our results indicate that a protocol which yields STP (5 Hz, 5 sec) when paired with coapplication of the beta-adrenergic agonist, isoproterenol (ISO), and the cholinergic agonist, carbachol (CCh), induces translation-dependent LTP in mouse CA1.	Carbachol	181-190	sulfotransferase family 1A, phenol-preferring, member 1	Mus musculus	50-53
22962328-4	2012	METHODS AND RESULTS: We demonstrate that IL-1beta-conditioned medium from RAW 264.7 macrophages induces differentiation of human adipose tissue-derived mesenchymal stem cells to alpha-smooth muscle actin-positive SMCs, and the differentiated SMCs exhibited increased contractility in response to KCl and carbachol treatment.	Carbachol	304-313	interleukin 1 beta	Homo sapiens	41-49
22859298-3	2012	In this study we identify Raf-1 kinase inhibitory protein as an essential mediator of ethanol-induced sensitization of cholecystokinin- and carbachol-regulated Ca(2+) signaling in pancreatic acinar cells.	Carbachol	140-149	phosphatidylethanolamine binding protein 1	Homo sapiens	26-57
22903161-0	2012	Roles of AQP5/AQP5-G103D in carbamylcholine-induced volume decrease and in reduction of the activation energy for water transport by rat parotid acinar cells.	Carbachol	28-43	aquaporin 5	Rattus norvegicus	9-13
22903161-0	2012	Roles of AQP5/AQP5-G103D in carbamylcholine-induced volume decrease and in reduction of the activation energy for water transport by rat parotid acinar cells.	Carbachol	28-43	aquaporin 5	Rattus norvegicus	14-18
22859298-5	2012	Furthermore, we show that either suppression of Raf-1 kinase inhibitory protein expression using short hairpin RNA or gene ablation prevented the sensitizing effects of ethanol on cholecystokinin- and carbachol-stimulated Ca(2+) signaling and intracellular chymotrypsin activation in pancreatic acinar cells, suggesting that the modulation of Raf-1 inhibitory protein expression may have future therapeutic utility in the prevention or treatment of alcohol-associated pancreatitis.	Carbachol	201-210	phosphatidylethanolamine binding protein 1	Homo sapiens	48-79
22859298-5	2012	Furthermore, we show that either suppression of Raf-1 kinase inhibitory protein expression using short hairpin RNA or gene ablation prevented the sensitizing effects of ethanol on cholecystokinin- and carbachol-stimulated Ca(2+) signaling and intracellular chymotrypsin activation in pancreatic acinar cells, suggesting that the modulation of Raf-1 inhibitory protein expression may have future therapeutic utility in the prevention or treatment of alcohol-associated pancreatitis.	Carbachol	201-210	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	48-53
22644105-1	2012	This study aimed to characterize the beta-adrenoceptor (beta-AR) subtype mediating relaxation of isolated human bladder strips and to explore relaxation by the novel beta3-AR-selective agonist KUC-7322 for its relaxant effect on the human isolated detrusor and for its effect on the carbachol (CCh)-induced contractile response.	Carbachol	283-292	adrenoceptor beta 3	Homo sapiens	166-174
22975404-11	2012	Cch-stimulated increase in [Ca(2+)](i) was blocked by inhibitors for the M(1)AchRs, matrix metalloproteinases, and EGF receptors.	Carbachol	0-3	epidermal growth factor like 1	Rattus norvegicus	115-118
22975404-12	2012	Inhibitors against the EGF receptor and ERK 1/2 also blocked Cch-stimulated mucin secretion.	Carbachol	61-64	epidermal growth factor receptor	Rattus norvegicus	23-35
22975404-12	2012	Inhibitors against the EGF receptor and ERK 1/2 also blocked Cch-stimulated mucin secretion.	Carbachol	61-64	mitogen activated protein kinase 3	Rattus norvegicus	40-47
22975404-12	2012	Inhibitors against the EGF receptor and ERK 1/2 also blocked Cch-stimulated mucin secretion.	Carbachol	61-64	solute carrier family 13 member 2	Rattus norvegicus	76-81
22430195-1	2012	The relaxant effect of an aryloxypropanolamine beta3-adrenoceptor agonist on carbachol pre-contracted human detrusor muscle strips was evaluated and compared with literature results from reference compounds of similar mode of action, including mirabegron.	Carbachol	77-86	adrenoceptor beta 3	Homo sapiens	47-65
22115428-8	2012	Bladder strips from Eln(+/-) -sham mice showed a significantly heightened contractile response to both EFS and carbachol compared with Wt-sham mice.	Carbachol	111-120	elastin	Mus musculus	20-28
22115428-10	2012	CONCLUSION:   The results that elastin-deficient mice had decreased bladder compliance and capacity and increased bladder contractility; and that Wt-pBOO mice showed an enhanced contractile response to carbachol, but Eln(+/-) -pBOO mice did not, suggest that elastin is critical for normal bladder function and is involved in bladder response to pBOO.	Carbachol	202-211	elastin	Mus musculus	259-266
22644105-1	2012	This study aimed to characterize the beta-adrenoceptor (beta-AR) subtype mediating relaxation of isolated human bladder strips and to explore relaxation by the novel beta3-AR-selective agonist KUC-7322 for its relaxant effect on the human isolated detrusor and for its effect on the carbachol (CCh)-induced contractile response.	Carbachol	294-297	adrenoceptor beta 3	Homo sapiens	166-174
25279100-6	2012	Intracellular calcium level measurements in transfected cells revealed a more intensive carbachol induced increase of calcium concentration in HEK 293 cells expressing TRPC6P112Q versus the cells expressing wild-type TRPC6.	Carbachol	88-97	TRPC6 pseudogene 1	Homo sapiens	168-174
21878485-5	2012	Hippocampal slice preparations from NRG1(tg-type I) mice exhibited a reduced frequency of carbachol-induced gamma oscillations and an increased tendency to epileptiform activity.	Carbachol	90-99	neuregulin 1	Mus musculus	36-40
22683571-10	2012	In human lung slices, chronic beta-agonist exposure culminated in 64 +- 5.7% (P &lt; 0.001) desensitization of beta(2)AR-mediated dilation of carbachol-constricted airways that was reversed by chloroquine.	Carbachol	142-151	adrenoceptor beta 2	Homo sapiens	111-120
25279100-6	2012	Intracellular calcium level measurements in transfected cells revealed a more intensive carbachol induced increase of calcium concentration in HEK 293 cells expressing TRPC6P112Q versus the cells expressing wild-type TRPC6.	Carbachol	88-97	transient receptor potential cation channel subfamily C member 6	Homo sapiens	168-173
22511543-5	2012	Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor.	Carbachol	0-9	caspase 3	Homo sapiens	157-166
22511543-5	2012	Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor.	Carbachol	0-9	mitogen-activated protein kinase 1	Homo sapiens	316-319
22511543-5	2012	Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor.	Carbachol	0-9	AKT serine/threonine kinase 1	Homo sapiens	364-367
22511543-5	2012	Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor.	Carbachol	0-9	epidermal growth factor receptor	Homo sapiens	385-417
22511543-5	2012	Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor.	Carbachol	0-9	epidermal growth factor receptor	Homo sapiens	419-423
22511543-5	2012	Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor.	Carbachol	11-14	caspase 3	Homo sapiens	157-166
22511543-5	2012	Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor.	Carbachol	11-14	mitogen-activated protein kinase 1	Homo sapiens	316-319
22511543-5	2012	Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor.	Carbachol	11-14	AKT serine/threonine kinase 1	Homo sapiens	364-367
22511543-5	2012	Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor.	Carbachol	11-14	epidermal growth factor receptor	Homo sapiens	385-417
22511543-5	2012	Carbachol (CCh), a muscarinic receptor-specific agonist, abrogated tumor necrosis factor alpha/interferon gamma-induced apoptosis through pathways involving caspase 3/7, but its cytoprotective effect was decreased by a M3R antagonist, a mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) inhibitor, a phosphatidylinositol 3-kinase/Akt inhibitor, or an epidermal growth factor receptor (EGFR) inhibitor.	Carbachol	11-14	epidermal growth factor receptor	Homo sapiens	419-423
22511543-6	2012	Ligation of M3R with CCh transactivated EGFR and phosphorylated ERK and Akt, the downstream targets of EGFR.	Carbachol	21-24	epidermal growth factor receptor	Homo sapiens	40-44
22511543-6	2012	Ligation of M3R with CCh transactivated EGFR and phosphorylated ERK and Akt, the downstream targets of EGFR.	Carbachol	21-24	mitogen-activated protein kinase 1	Homo sapiens	64-67
22511543-6	2012	Ligation of M3R with CCh transactivated EGFR and phosphorylated ERK and Akt, the downstream targets of EGFR.	Carbachol	21-24	AKT serine/threonine kinase 1	Homo sapiens	72-75
22511543-6	2012	Ligation of M3R with CCh transactivated EGFR and phosphorylated ERK and Akt, the downstream targets of EGFR.	Carbachol	21-24	epidermal growth factor receptor	Homo sapiens	103-107
22511543-8	2012	CCh stimulated Src phosphorylation and binding to EGFR.	Carbachol	0-3	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	15-18
22511543-8	2012	CCh stimulated Src phosphorylation and binding to EGFR.	Carbachol	0-3	epidermal growth factor receptor	Homo sapiens	50-54
22717634-7	2012	After the intravenous infusion of carbachol, blood concentrations of Ang I and Ang II in near-term ovine fetus were both significantly increased (P &lt; 0.05); however, blood concentration of vasopressin, values of blood gas, electrolytes and plasma osmolality in near-term ovine fetus were not significantly changed (P &gt; 0.05).	Carbachol	34-43	angiotensinogen	Homo sapiens	69-74
22717634-7	2012	After the intravenous infusion of carbachol, blood concentrations of Ang I and Ang II in near-term ovine fetus were both significantly increased (P &lt; 0.05); however, blood concentration of vasopressin, values of blood gas, electrolytes and plasma osmolality in near-term ovine fetus were not significantly changed (P &gt; 0.05).	Carbachol	34-43	angiotensinogen	Homo sapiens	79-85
22717634-7	2012	After the intravenous infusion of carbachol, blood concentrations of Ang I and Ang II in near-term ovine fetus were both significantly increased (P &lt; 0.05); however, blood concentration of vasopressin, values of blood gas, electrolytes and plasma osmolality in near-term ovine fetus were not significantly changed (P &gt; 0.05).	Carbachol	34-43	arginine vasopressin	Homo sapiens	192-203
22717634-8	2012	Blood levels of Ang I and Ang II in the atropine (M receptor antagonist) + carbachol intravenous administration group was lower than those in the carbachol group without atropine administration (P &lt; 0.05).	Carbachol	75-84	angiotensinogen	Homo sapiens	16-21
22717634-8	2012	Blood levels of Ang I and Ang II in the atropine (M receptor antagonist) + carbachol intravenous administration group was lower than those in the carbachol group without atropine administration (P &lt; 0.05).	Carbachol	75-84	angiotensinogen	Homo sapiens	26-32
22717634-8	2012	Blood levels of Ang I and Ang II in the atropine (M receptor antagonist) + carbachol intravenous administration group was lower than those in the carbachol group without atropine administration (P &lt; 0.05).	Carbachol	146-155	angiotensinogen	Homo sapiens	16-21
22717634-9	2012	In conclusion, this study indicates that the near-term changes of cardiovascular system induced by intravenous administration of carbachol in ovine fetus, such as blood pressure and heart rate, are associated with the changes of hormones of circulatory renin-angiotensin system.	Carbachol	129-138	renin	Homo sapiens	253-258
22449386-10	2012	SCA-9 cells exhibit a constitutive activation of NF-kappaB, which regulates carbachol-induced NOS2 and 3, arginase II and COX-1 expressions.	Carbachol	76-85	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	122-127
22493444-5	2012	The inhibition of PI3K by PIK-93, LY294002, or wortmannin decreased carbachol-induced translocation of TRPC6 to the plasma membrane and carbachol-induced net Ca(2+) entry into T6.11 cells.	Carbachol	68-77	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	103-108
22449386-7	2012	Phospholipase C (PLC)/nitric oxide synthase (NOS)/arginase pathway is involved in this effect, since carbachol stimulated nitric oxide production, increased NOS2 and NOS3 expressions, urea production, and arginase II expression (P&lt;0.001).	Carbachol	101-110	nitric oxide synthase 2	Homo sapiens	157-161
22449386-7	2012	Phospholipase C (PLC)/nitric oxide synthase (NOS)/arginase pathway is involved in this effect, since carbachol stimulated nitric oxide production, increased NOS2 and NOS3 expressions, urea production, and arginase II expression (P&lt;0.001).	Carbachol	101-110	nitric oxide synthase 3	Homo sapiens	166-170
22449386-8	2012	Also, phospholipase A2 (PLA2)/cyclooxygenase (COX) pathway is up-regulated in carbachol-induced SCA-9 cell proliferation, because prostaglandin E2 liberation (P&lt;0.001) is increased and COX-1 expression is turned up (P&lt;0.001).	Carbachol	78-87	phospholipase A2 group IB	Homo sapiens	6-22
22449386-8	2012	Also, phospholipase A2 (PLA2)/cyclooxygenase (COX) pathway is up-regulated in carbachol-induced SCA-9 cell proliferation, because prostaglandin E2 liberation (P&lt;0.001) is increased and COX-1 expression is turned up (P&lt;0.001).	Carbachol	78-87	phospholipase A2 group IB	Homo sapiens	24-28
22449386-8	2012	Also, phospholipase A2 (PLA2)/cyclooxygenase (COX) pathway is up-regulated in carbachol-induced SCA-9 cell proliferation, because prostaglandin E2 liberation (P&lt;0.001) is increased and COX-1 expression is turned up (P&lt;0.001).	Carbachol	78-87	SCA9	Homo sapiens	96-101
22449386-8	2012	Also, phospholipase A2 (PLA2)/cyclooxygenase (COX) pathway is up-regulated in carbachol-induced SCA-9 cell proliferation, because prostaglandin E2 liberation (P&lt;0.001) is increased and COX-1 expression is turned up (P&lt;0.001).	Carbachol	78-87	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	188-193
22449386-10	2012	SCA-9 cells exhibit a constitutive activation of NF-kappaB, which regulates carbachol-induced NOS2 and 3, arginase II and COX-1 expressions.	Carbachol	76-85	SCA9	Homo sapiens	0-5
22449386-10	2012	SCA-9 cells exhibit a constitutive activation of NF-kappaB, which regulates carbachol-induced NOS2 and 3, arginase II and COX-1 expressions.	Carbachol	76-85	nuclear factor kappa B subunit 1	Homo sapiens	49-58
22449386-10	2012	SCA-9 cells exhibit a constitutive activation of NF-kappaB, which regulates carbachol-induced NOS2 and 3, arginase II and COX-1 expressions.	Carbachol	76-85	nitric oxide synthase 2	Homo sapiens	94-104
21951618-15	2012	In contrast, carbachol-induced TRPC6 channel activity was significantly inhibited (87.3%) by SCE in green fluorescent protein-TRPC6 pcDNA transfected HEK 293 cells.	Carbachol	13-22	transient receptor potential cation channel subfamily C member 6	Homo sapiens	31-36
21951618-15	2012	In contrast, carbachol-induced TRPC6 channel activity was significantly inhibited (87.3%) by SCE in green fluorescent protein-TRPC6 pcDNA transfected HEK 293 cells.	Carbachol	13-22	transient receptor potential cation channel subfamily C member 6	Homo sapiens	126-131
22173970-2	2012	Agonists, such as carbachol, and hormones that increase intracellular calcium concentration can activate AKT leading to cancer cell survival.	Carbachol	18-27	AKT serine/threonine kinase 1	Homo sapiens	105-108
22173970-6	2012	Our goals were to examine the mechanism of carbachol activation of AKT and BAD in LNCaP prostate cancer cells and evaluate whether CaM KK may be mediating carbachol"s activation of AKT and cell survival.	Carbachol	43-52	AKT serine/threonine kinase 1	Homo sapiens	67-70
22173970-6	2012	Our goals were to examine the mechanism of carbachol activation of AKT and BAD in LNCaP prostate cancer cells and evaluate whether CaM KK may be mediating carbachol"s activation of AKT and cell survival.	Carbachol	155-164	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	131-137
22173970-6	2012	Our goals were to examine the mechanism of carbachol activation of AKT and BAD in LNCaP prostate cancer cells and evaluate whether CaM KK may be mediating carbachol"s activation of AKT and cell survival.	Carbachol	155-164	AKT serine/threonine kinase 1	Homo sapiens	181-184
22173970-7	2012	Our results suggest that carbachol treatment of LNCaP cells promoted cell survival through CaM KK and its phosphorylation of AKT.	Carbachol	25-34	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	91-97
22173970-7	2012	Our results suggest that carbachol treatment of LNCaP cells promoted cell survival through CaM KK and its phosphorylation of AKT.	Carbachol	25-34	AKT serine/threonine kinase 1	Homo sapiens	125-128
22173970-8	2012	The bacterial toxin anisomycin triggered caspase-3 activation in LNCaP cells that was blocked by carbachol in a CaM KK- and AKT-dependent manner.	Carbachol	97-106	caspase 3	Homo sapiens	41-50
22173970-8	2012	The bacterial toxin anisomycin triggered caspase-3 activation in LNCaP cells that was blocked by carbachol in a CaM KK- and AKT-dependent manner.	Carbachol	97-106	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	112-118
22173970-8	2012	The bacterial toxin anisomycin triggered caspase-3 activation in LNCaP cells that was blocked by carbachol in a CaM KK- and AKT-dependent manner.	Carbachol	97-106	AKT serine/threonine kinase 1	Homo sapiens	124-127
22449386-11	2012	In addition, protein kinase C is involved in the up-regulation of NOS2 and arginase II enzymes induced by carbachol via NF-kappaB.	Carbachol	106-115	nitric oxide synthase 2	Homo sapiens	66-70
22449386-11	2012	In addition, protein kinase C is involved in the up-regulation of NOS2 and arginase II enzymes induced by carbachol via NF-kappaB.	Carbachol	106-115	nuclear factor kappa B subunit 1	Homo sapiens	120-129
22205227-3	2012	Muscle activation with KCl, carbachol (CCh), or prostaglandin E(2) at short muscle lengths can increase APS that is revealed by elevated pseudo-steady-state T(p) at longer lengths compared with prior T(p) measurements at those lengths, and APS generation is inhibited by the Rho Kinase (ROCK) inhibitor H-1152.	Carbachol	28-37	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	275-285
22205227-3	2012	Muscle activation with KCl, carbachol (CCh), or prostaglandin E(2) at short muscle lengths can increase APS that is revealed by elevated pseudo-steady-state T(p) at longer lengths compared with prior T(p) measurements at those lengths, and APS generation is inhibited by the Rho Kinase (ROCK) inhibitor H-1152.	Carbachol	28-37	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	287-291
22205227-3	2012	Muscle activation with KCl, carbachol (CCh), or prostaglandin E(2) at short muscle lengths can increase APS that is revealed by elevated pseudo-steady-state T(p) at longer lengths compared with prior T(p) measurements at those lengths, and APS generation is inhibited by the Rho Kinase (ROCK) inhibitor H-1152.	Carbachol	39-42	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	275-285
22205227-3	2012	Muscle activation with KCl, carbachol (CCh), or prostaglandin E(2) at short muscle lengths can increase APS that is revealed by elevated pseudo-steady-state T(p) at longer lengths compared with prior T(p) measurements at those lengths, and APS generation is inhibited by the Rho Kinase (ROCK) inhibitor H-1152.	Carbachol	39-42	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	287-291
22205227-6	2012	In addition, CCh-induced APS in whole mouse bladder was inhibited by H-1152, indicating that ROCK activity may regulate bladder compliance during filling.	Carbachol	13-16	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	93-97
22351639-7	2012	Under conditions that specifically isolate apical Ca(2+)-activated Cl(-) channel (CaCC) currents, EGF pretreatment (100 ng ml(-1) for 15 min) potentiated carbachol (CCh)-induced responses to 173 +- 25% of those in control cells, when measured 24 h later (n = 26; P &lt; 0.01).	Carbachol	154-163	anoctamin 1	Homo sapiens	82-86
21957094-7	2012	Carbachol-induced myofibroblast transition was mediated by an increase in ERK1/2 phosphorylation, RhoA-GTP activation and cyclic monophosphate downregulation as well as by the autocrine TGF-beta1 release, which were effectively reduced by aclidinium.	Carbachol	0-9	mitogen-activated protein kinase 3	Homo sapiens	74-80
22466505-2	2012	We found that carbachol-induced oscillations in rat CA3 have biphasic phase-response curves, consistent with the ability to couple with oscillations in afferent projections.	Carbachol	14-23	carbonic anhydrase 3	Rattus norvegicus	52-55
21885397-10	2012	Carbachol stimulated release of LTB(4) from lung macrophages (buffer 222.3 +- 75.1 versus carbachol 1,118 +- 622.4 pg   mL(-1); n = 15, p&lt;0.05) but not IL-6 or IL-8.	Carbachol	0-9	interleukin 6	Homo sapiens	155-159
21885397-10	2012	Carbachol stimulated release of LTB(4) from lung macrophages (buffer 222.3 +- 75.1 versus carbachol 1,118 +- 622.4 pg   mL(-1); n = 15, p&lt;0.05) but not IL-6 or IL-8.	Carbachol	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
22138972-7	2012	In scratch wound assays we also demonstrated (using the selective NHE inhibitor HOE-642) that carbachol and insulin like growth factor II (IGF-II) partly stimulate migration of HGMs in a NHE1-dependent manner.	Carbachol	94-103	solute carrier family 9 member C1	Homo sapiens	66-69
22138972-7	2012	In scratch wound assays we also demonstrated (using the selective NHE inhibitor HOE-642) that carbachol and insulin like growth factor II (IGF-II) partly stimulate migration of HGMs in a NHE1-dependent manner.	Carbachol	94-103	solute carrier family 9 member A1	Homo sapiens	187-191
22138972-11	2012	In addition, we demonstrated that NHE1 activity contributes to both IGF-II- and carbachol-stimulated migration and that it is obligatory for IGF-II-induced proliferation of HGMs.	Carbachol	80-89	solute carrier family 9 member A1	Homo sapiens	34-38
22281988-6	2012	The overexpression of RGS5 impaired the release of Ca(2+) to thrombin, histamine, and carbachol, and reduced the contraction of precision-cut lung slices to carbachol.	Carbachol	86-95	regulator of G protein signaling 5	Homo sapiens	22-26
22281988-6	2012	The overexpression of RGS5 impaired the release of Ca(2+) to thrombin, histamine, and carbachol, and reduced the contraction of precision-cut lung slices to carbachol.	Carbachol	157-166	regulator of G protein signaling 5	Homo sapiens	22-26
21692984-11	2012	Addition of the PKC activator, phorbol 12-myristate 13-acetate and the specific PKC(epsilon) agonist, carbachol, blocked the effects of nicorandil on connexin43 phosphorylation and dye permeability.	Carbachol	102-111	gap junction protein, alpha 1	Rattus norvegicus	150-160
21899666-8	2012	CCh was found to reorganize alpha-fodrin in HSG cells in a Ca(2+) -dependent manner.	Carbachol	0-3	spectrin alpha, non-erythrocytic 1	Homo sapiens	28-40
21899666-9	2012	However, pretreatment with SS IgG prevented the cytoskeletal reorganization of alpha-fodrin induced by CCh.	Carbachol	103-106	spectrin alpha, non-erythrocytic 1	Homo sapiens	79-91
22197203-8	2012	TRK-380 had a concentration-dependent relaxing effect on the contractile responses to carbachol and KCl in human detrusor strips.	Carbachol	86-95	neurotrophic receptor tyrosine kinase 1	Homo sapiens	0-3
21254300-12	2012	Moreover, we could also show that both chemical late-LTP and carbachol-reinforced early-LTP-induced STC processes are mediated by the neurotrophin BDNF.	Carbachol	61-70	brain derived neurotrophic factor	Homo sapiens	147-151
21957094-7	2012	Carbachol-induced myofibroblast transition was mediated by an increase in ERK1/2 phosphorylation, RhoA-GTP activation and cyclic monophosphate downregulation as well as by the autocrine TGF-beta1 release, which were effectively reduced by aclidinium.	Carbachol	0-9	ras homolog family member A	Homo sapiens	98-102
21957094-7	2012	Carbachol-induced myofibroblast transition was mediated by an increase in ERK1/2 phosphorylation, RhoA-GTP activation and cyclic monophosphate downregulation as well as by the autocrine TGF-beta1 release, which were effectively reduced by aclidinium.	Carbachol	0-9	transforming growth factor beta 1	Homo sapiens	186-195
22069319-13	2012	IFN-gamma also abrogates the ability of EGF to inhibit carbachol-stimulated basolateral K(+) currents.	Carbachol	55-64	interferon gamma	Mus musculus	0-9
21956166-12	2012	Biotinylation studies revealed that carbachol inhibits oxalate transport by reducing SLC26A6 surface expression.	Carbachol	36-45	solute carrier family 26 member 6	Homo sapiens	85-92
21956166-7	2012	Cholinergic stimulation with carbachol modulates intestinal ion transport through signaling pathways including PKC activation.	Carbachol	29-38	protein kinase C delta	Homo sapiens	111-114
21956166-13	2012	We conclude that carbachol negatively regulates oxalate transport by reducing SLC26A6 surface expression in T84 cells through signaling pathways including the M(3) muscarinic receptor, phospholipase C, PKC-delta, and c-Src.	Carbachol	17-26	solute carrier family 26 member 6	Homo sapiens	78-85
21956166-10	2012	Carbachol also led to significant translocation of PKC-delta from the cytosol to the membrane of T84 cells.	Carbachol	0-9	protein kinase C delta	Homo sapiens	51-60
21956166-13	2012	We conclude that carbachol negatively regulates oxalate transport by reducing SLC26A6 surface expression in T84 cells through signaling pathways including the M(3) muscarinic receptor, phospholipase C, PKC-delta, and c-Src.	Carbachol	17-26	cholinergic receptor muscarinic 3	Homo sapiens	159-183
21956166-11	2012	Using pharmacological inhibitors, we observed that carbachol inhibits oxalate transport through the M(3) muscarinic receptor and phospholipase C. Utilizing the Src inhibitor PP2 and phosphorylation studies, we found that the observed regulation downstream of PKC-delta is partially mediated by c-Src.	Carbachol	51-60	cholinergic receptor muscarinic 3	Homo sapiens	100-124
21956166-11	2012	Using pharmacological inhibitors, we observed that carbachol inhibits oxalate transport through the M(3) muscarinic receptor and phospholipase C. Utilizing the Src inhibitor PP2 and phosphorylation studies, we found that the observed regulation downstream of PKC-delta is partially mediated by c-Src.	Carbachol	51-60	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	160-163
21956166-13	2012	We conclude that carbachol negatively regulates oxalate transport by reducing SLC26A6 surface expression in T84 cells through signaling pathways including the M(3) muscarinic receptor, phospholipase C, PKC-delta, and c-Src.	Carbachol	17-26	protein kinase C delta	Homo sapiens	202-211
21956166-13	2012	We conclude that carbachol negatively regulates oxalate transport by reducing SLC26A6 surface expression in T84 cells through signaling pathways including the M(3) muscarinic receptor, phospholipase C, PKC-delta, and c-Src.	Carbachol	17-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	217-222
21956166-11	2012	Using pharmacological inhibitors, we observed that carbachol inhibits oxalate transport through the M(3) muscarinic receptor and phospholipase C. Utilizing the Src inhibitor PP2 and phosphorylation studies, we found that the observed regulation downstream of PKC-delta is partially mediated by c-Src.	Carbachol	51-60	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	174-177
22613970-5	2012	We found that the muscarinic agonist carbachol and the ryanodine receptor agonists caffeine and 4-chloro-m-cresol had more potent depolarizing effects on Anx7(+/-) beta-cells compared to controls.	Carbachol	37-46	annexin A7	Mus musculus	154-158
21956166-11	2012	Using pharmacological inhibitors, we observed that carbachol inhibits oxalate transport through the M(3) muscarinic receptor and phospholipase C. Utilizing the Src inhibitor PP2 and phosphorylation studies, we found that the observed regulation downstream of PKC-delta is partially mediated by c-Src.	Carbachol	51-60	protein kinase C delta	Homo sapiens	259-268
21956166-11	2012	Using pharmacological inhibitors, we observed that carbachol inhibits oxalate transport through the M(3) muscarinic receptor and phospholipase C. Utilizing the Src inhibitor PP2 and phosphorylation studies, we found that the observed regulation downstream of PKC-delta is partially mediated by c-Src.	Carbachol	51-60	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	294-299
22916223-6	2012	Stimulation of human tracheal mucosa with PAR2-activating peptide (PAR2-AP) elevated intracellular Ca(2+) and induced glandular secretion equal to approximately 30% of the carbachol response in the human airway.	Carbachol	172-181	F2R like trypsin receptor 1	Homo sapiens	42-46
21883831-8	2012	Rho-kinase inhibitor Y27632 (10 microM) inhibited peak and sustained contractile responses to carbachol in control bladders (peak by 38%; plateau 57%) and obstructed bladders (peak 37% plateau 47%).	Carbachol	94-103	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	0-10
22972200-8	2012	PrP-positive cells with automaticity showed positive and negative chronotropic responses to isoproterenol and carbamylcholine, respectively.	Carbachol	110-125	prion protein	Mus musculus	0-3
22916223-6	2012	Stimulation of human tracheal mucosa with PAR2-activating peptide (PAR2-AP) elevated intracellular Ca(2+) and induced glandular secretion equal to approximately 30% of the carbachol response in the human airway.	Carbachol	172-181	coagulation factor II (thrombin) receptor-like 1	Mus musculus	67-71
21945499-9	2011	Furthermore, by introduction of miR-145, ES-pre-SMC proliferation was significantly inhibited and carbachol-stimulated contraction of ES-pre-SMCs was significantly increased.	Carbachol	98-107	microRNA 145	Homo sapiens	32-39
23115638-7	2012	We report that Orai1-mediated Ca(2+) entry generates [Ca(2+)](i) oscillations at different [CCh], ranging from very low to high.	Carbachol	92-95	ORAI calcium release-activated calcium modulator 1	Homo sapiens	15-20
23115638-8	2012	In contrast, TRPC1-mediated Ca(2+) entry generates sustained [Ca(2+)](i) elevation at high [CCh] and contributes to frequency of [Ca(2+)](i) oscillations at lower [agonist].	Carbachol	92-95	transient receptor potential cation channel subfamily C member 1	Homo sapiens	13-18
21884684-7	2011	In hippocampal slices carbachol increased the levels of two extracellular matrix protein, fibronectin and laminin-1, by 1.6-fold, as measured by Western blot.	Carbachol	22-31	fibronectin 1	Rattus norvegicus	90-101
21884684-7	2011	In hippocampal slices carbachol increased the levels of two extracellular matrix protein, fibronectin and laminin-1, by 1.6-fold, as measured by Western blot.	Carbachol	22-31	laminin subunit alpha 1	Rattus norvegicus	106-115
21884684-10	2011	Furthermore, function-blocking fibronectin or laminin-1 antibodies antagonized the effect of carbachol on neurite outgrowth.	Carbachol	93-102	fibronectin 1	Rattus norvegicus	31-42
21884684-10	2011	Furthermore, function-blocking fibronectin or laminin-1 antibodies antagonized the effect of carbachol on neurite outgrowth.	Carbachol	93-102	laminin subunit alpha 1	Rattus norvegicus	46-55
21884684-12	2011	By decreasing fibronectin and laminin levels ethanol prevents carbachol-induced neuritogenesis.	Carbachol	62-71	fibronectin 1	Rattus norvegicus	14-25
21933938-4	2011	Interactions among carbachol, PKC inhibitors, phorbol 12-myristate 13-acetate, and thapsigargin to modulate [Ca(2+)](i) implicated conventional PKC isoforms in mediating sustained secretion.	Carbachol	19-28	proline rich transmembrane protein 2	Homo sapiens	144-147
21933938-5	2011	With increasing times during carbachol perfusion of glands, in situ, PKC-alpha redistributed across glandular membrane compartments and underwent a rapid and persistent accumulation near the luminal borders of mucous cells.	Carbachol	29-38	protein kinase C alpha	Homo sapiens	69-78
22004286-5	2011	The PKC inhibitor Go6976 (1mumol L(-1) ) inhibited the carbachol-induced phosphorylation of CPI-17, whereas the Rho-associated kinase (ROCK) inhibitor, Y-27632 (10mumol L(-1) ) inhibited the carbachol-induced phosphorylation of both CPI-17 and MYPT1.	Carbachol	55-64	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	92-98
22004286-5	2011	The PKC inhibitor Go6976 (1mumol L(-1) ) inhibited the carbachol-induced phosphorylation of CPI-17, whereas the Rho-associated kinase (ROCK) inhibitor, Y-27632 (10mumol L(-1) ) inhibited the carbachol-induced phosphorylation of both CPI-17 and MYPT1.	Carbachol	55-64	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	233-239
22004286-5	2011	The PKC inhibitor Go6976 (1mumol L(-1) ) inhibited the carbachol-induced phosphorylation of CPI-17, whereas the Rho-associated kinase (ROCK) inhibitor, Y-27632 (10mumol L(-1) ) inhibited the carbachol-induced phosphorylation of both CPI-17 and MYPT1.	Carbachol	55-64	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	244-249
22004286-5	2011	The PKC inhibitor Go6976 (1mumol L(-1) ) inhibited the carbachol-induced phosphorylation of CPI-17, whereas the Rho-associated kinase (ROCK) inhibitor, Y-27632 (10mumol L(-1) ) inhibited the carbachol-induced phosphorylation of both CPI-17 and MYPT1.	Carbachol	191-200	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	92-98
22001099-5	2011	Carbachol (1 muM) increased the spontaneous contractile rate of these tissue strips by 122% +- 27% (P &lt; .001).	Carbachol	0-9	latexin	Homo sapiens	13-16
22001099-8	2011	Darifenacin, oxybutynin, tolterodine, and solifenacin (1 muM) all significantly depressed the frequency responses to carbachol (1 muM).	Carbachol	117-126	latexin	Homo sapiens	57-60
22001099-8	2011	Darifenacin, oxybutynin, tolterodine, and solifenacin (1 muM) all significantly depressed the frequency responses to carbachol (1 muM).	Carbachol	117-126	latexin	Homo sapiens	130-133
21859823-3	2011	We first verified that cannabinoids (CP55,940 and WIN55,212-2) readily suppressed carbachol-induced gamma oscillations in the CA3 region of hippocampal slices via activation of CB(1)Rs.	Carbachol	82-91	carbonic anhydrase 3	Homo sapiens	126-129
22937150-5	2012	Myocardin overexpression from day 10 to day 28 of embryoid body differentiation increased the number of smooth muscle alpha-actin(+) and smooth muscle myosin heavy chain(+) SMC-like cells and increased carbachol-induced contractile function.	Carbachol	202-211	myocardin	Homo sapiens	0-9
22004286-4	2011	Key Results  In rat ileal smooth muscle, phosphorylation level of CPI-17 at Thr(38) and MYPT1 at Thr(853) , but not MYPT1 at Thr(696) , were increased with carbachol (1mumolL(-1) ) accompanied with muscle contraction.	Carbachol	156-165	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	66-72
22004286-4	2011	Key Results  In rat ileal smooth muscle, phosphorylation level of CPI-17 at Thr(38) and MYPT1 at Thr(853) , but not MYPT1 at Thr(696) , were increased with carbachol (1mumolL(-1) ) accompanied with muscle contraction.	Carbachol	156-165	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	88-93
21940627-5	2011	Carbachol, a known nAChR and muscarinic receptor agonist, up-regulated both alpha4beta2 nAChR binding sites and subunit protein 2-fold more than did nicotine.	Carbachol	0-9	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	19-24
21940627-5	2011	Carbachol, a known nAChR and muscarinic receptor agonist, up-regulated both alpha4beta2 nAChR binding sites and subunit protein 2-fold more than did nicotine.	Carbachol	0-9	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	88-93
21874246-7	2011	In addition, ghrelin enhanced smooth muscle strip contraction induced by carbachol.	Carbachol	73-82	ghrelin and obestatin prepropeptide	Rattus norvegicus	13-20
21567383-5	2011	Carbachol was synthesized with an active choline group and was conjugated with an siRNA that targets caspase 3.	Carbachol	0-9	caspase 3	Homo sapiens	101-110
21684833-11	2011	After ozone exposure, bronchial rings derived from mindin-/- mice demonstrated reduced constriction in response to carbachol.	Carbachol	115-124	spondin 2, extracellular matrix protein	Mus musculus	51-57
21410689-3	2011	EXPERIMENTAL APPROACH Effects of BNP on responses to carbachol and histamine were evaluated in non-sensitized, passively sensitized, epithelium-intact or denuded isolated bronchi and in the presence of methoctramine, N(omega) -nitro-L-arginine methyl ester (L-NAME) and aminoguanidine.	Carbachol	53-62	natriuretic peptide B	Homo sapiens	33-36
21918251-6	2011	RESULTS: According to conducted testing, activation of soluble guanylyl cyclase with the use of YC-1 and 8Br cGMP caused reduced reaction of the tracheal smooth muscle with carbachol on average to 80%.	Carbachol	173-182	glutathione S-transferase alpha 1	Rattus norvegicus	96-106
21306750-7	2011	Insulin secretion induced by the protein kinase A (PKA) activators forskolin and 3-isobutyl-1-methyl-xanthine, in the presence of 11.1 mmol/L glucose, was lower in LDLR(-/-) islets and was normalized in the presence of the protein kinase C pathway activators carbachol and phorbol 12-myristate 13-acetate.	Carbachol	259-268	low density lipoprotein receptor	Mus musculus	164-168
20805763-8	2011	RESULTS: Carbachol inhibited expression of TNF-alpha and IL-6 after LPS injection and had no significant effect on IL-10 in rat endotoxemia model.	Carbachol	9-18	tumor necrosis factor	Rattus norvegicus	43-52
21371005-6	2011	KEY RESULTS: Ang-(1-7)-treated apoE (-/-) mice showed improved renal endothelium-dependent vasorelaxation induced by carbachol and increased renal basal cGMP production, compared with untreated apoE (-/-) mice.	Carbachol	117-126	apolipoprotein E	Mus musculus	31-35
21402151-7	2011	Phosphorylation of TRPC7 significantly suppressed carbachol-induced calcium influx and CREB phosphorylation.	Carbachol	50-59	transient receptor potential cation channel, subfamily C, member 7	Mus musculus	19-24
21402151-7	2011	Phosphorylation of TRPC7 significantly suppressed carbachol-induced calcium influx and CREB phosphorylation.	Carbachol	50-59	cAMP responsive element binding protein 1	Mus musculus	87-91
20805763-8	2011	RESULTS: Carbachol inhibited expression of TNF-alpha and IL-6 after LPS injection and had no significant effect on IL-10 in rat endotoxemia model.	Carbachol	9-18	interleukin 6	Rattus norvegicus	57-61
21570469-4	2011	Carbachol- and PDBu-induced sAPPalpha secretions were blocked by the general PKC inhibitor GF109203X.	Carbachol	0-9	protein kinase C alpha	Homo sapiens	77-80
20805763-10	2011	Cell experiments also showed that increases of TNF-alpha and IL-6 after LPS stimulation could be significantly inhibited by carbachol or nicotine, whereas IL-10 was not apparently altered.	Carbachol	124-133	tumor necrosis factor	Rattus norvegicus	47-56
20805763-10	2011	Cell experiments also showed that increases of TNF-alpha and IL-6 after LPS stimulation could be significantly inhibited by carbachol or nicotine, whereas IL-10 was not apparently altered.	Carbachol	124-133	interleukin 6	Rattus norvegicus	61-65
21338617-1	2011	In SH-SY5Y human neuroblastoma cells, the cholinergic agonist, carbachol, stimulates phosphorylation of the small heat shock protein 27 (HSP27).	Carbachol	63-72	heat shock protein family B (small) member 1	Homo sapiens	114-135
21338617-1	2011	In SH-SY5Y human neuroblastoma cells, the cholinergic agonist, carbachol, stimulates phosphorylation of the small heat shock protein 27 (HSP27).	Carbachol	63-72	heat shock protein family B (small) member 1	Homo sapiens	137-142
21338617-4	2011	This response to carbachol is partially reduced by inhibition of protein kinase C (PKC) with GF 109203X and p38 mitogen-activated protein kinase (MAPK) with SB 203580.	Carbachol	17-26	mitogen-activated protein kinase 14	Homo sapiens	108-144
21338617-8	2011	SH-SY5Y cells differentiated with a low concentration of PDB and basic fibroblast growth factor to a more neuronal phenotype retain carbachol-, PDB- and Akti-1/2-responsive HSP27 phosphorylation.	Carbachol	132-141	heat shock protein family B (small) member 1	Homo sapiens	173-178
21338617-9	2011	Immunofluorescence microscopy confirms increased HSP27 phosphorylation in response to carbachol or PDB.	Carbachol	86-95	heat shock protein family B (small) member 1	Homo sapiens	49-54
21497590-5	2011	Activation of BKCa channels by NS1619 had a minor inhibitory effect on carbachol-induced phasic activity of bladder strips from control and diabetic rats, and significantly inhibited amplitude only at 30 muM.	Carbachol	71-80	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	14-18
20705939-3	2011	We found that the carbachol-stimulated cytoskeletal recruitment of actin-related protein-3 (Arp3), metavinculin, and talin were up-regulated at short muscle lengths and down-regulated at long muscle lengths, suggesting that the actin cytoskeleton--integrin complex becomes enriched in cross-linked and branched actin filaments in shortened ASM.	Carbachol	18-27	actin related protein 3	Homo sapiens	67-90
20705939-3	2011	We found that the carbachol-stimulated cytoskeletal recruitment of actin-related protein-3 (Arp3), metavinculin, and talin were up-regulated at short muscle lengths and down-regulated at long muscle lengths, suggesting that the actin cytoskeleton--integrin complex becomes enriched in cross-linked and branched actin filaments in shortened ASM.	Carbachol	18-27	actin related protein 3	Homo sapiens	92-96
20705939-3	2011	We found that the carbachol-stimulated cytoskeletal recruitment of actin-related protein-3 (Arp3), metavinculin, and talin were up-regulated at short muscle lengths and down-regulated at long muscle lengths, suggesting that the actin cytoskeleton--integrin complex becomes enriched in cross-linked and branched actin filaments in shortened ASM.	Carbachol	18-27	vinculin	Homo sapiens	99-111
21527320-5	2011	When recording carbachol-evoked inhibitory postsynaptic currents (IPSCs) which presumably originate from CB1 expressing cholecystokinin (CCK) interneurons, we found that depolarization-induced suppression of inhibition (DSI) was impaired by the stress.	Carbachol	15-24	cannabinoid receptor 1	Rattus norvegicus	105-108
21527320-5	2011	When recording carbachol-evoked inhibitory postsynaptic currents (IPSCs) which presumably originate from CB1 expressing cholecystokinin (CCK) interneurons, we found that depolarization-induced suppression of inhibition (DSI) was impaired by the stress.	Carbachol	15-24	cholecystokinin	Rattus norvegicus	137-140
21474425-9	2011	Desensitization of intracolonic TRPV1 receptors before the induction of acute colitis restored the response of isolated detrusor strips to CCh but not to EFS stimulation.	Carbachol	139-142	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	32-37
21265824-5	2011	The Rho-kinase inhibitors decreased the spontaneous contractions and the responses to carbachol and substance P independently of neuronal inputs, suggesting Y-27632 acts directly on smooth muscle.	Carbachol	86-95	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	4-14
21265824-6	2011	The Rho-kinase inhibitors significantly reduced the depolarization in response to carbachol, an effect that cannot be due to regulation of Ca(2+) sensitization.	Carbachol	82-91	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	4-14
21265824-8	2011	CONCLUSIONS AND IMPLICATIONS: The Rho-kinase inhibitors decreased contractions evoked by nerve stimulation, carbachol and substance P.	Carbachol	108-117	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	34-44
21466795-1	2011	Microinjection of the cholinergic agonist carbachol into the bed nucleus of the stria terminalis (BST) has been reported to cause pressor response in unanesthetized rats, which was shown to be mediated by an acute release of vasopressin into the systemic circulation and followed by baroreflex-mediated bradycardia.	Carbachol	42-51	arginine vasopressin	Rattus norvegicus	225-236
21466795-5	2011	Moreover, BST treatment with carbachol significantly increased plasma vasopressin levels, thus confirming previous evidences that carbachol microinjection into the BST evokes pressor response due to vasopressin release into the circulation.	Carbachol	29-38	arginine vasopressin	Rattus norvegicus	70-81
21466795-5	2011	Moreover, BST treatment with carbachol significantly increased plasma vasopressin levels, thus confirming previous evidences that carbachol microinjection into the BST evokes pressor response due to vasopressin release into the circulation.	Carbachol	29-38	arginine vasopressin	Rattus norvegicus	199-210
21466795-5	2011	Moreover, BST treatment with carbachol significantly increased plasma vasopressin levels, thus confirming previous evidences that carbachol microinjection into the BST evokes pressor response due to vasopressin release into the circulation.	Carbachol	130-139	arginine vasopressin	Rattus norvegicus	70-81
21466795-5	2011	Moreover, BST treatment with carbachol significantly increased plasma vasopressin levels, thus confirming previous evidences that carbachol microinjection into the BST evokes pressor response due to vasopressin release into the circulation.	Carbachol	130-139	arginine vasopressin	Rattus norvegicus	199-210
21453700-5	2011	Results show that multiple pathways are involved in the effects of carbachol on astrocyte-mediated increases in fibronectin expression and neuritogenesis.	Carbachol	67-76	fibronectin 1	Rattus norvegicus	112-123
21406187-4	2011	HD (2 or 15 days) reduced the pressor responses to ANG II (50 ng/1mul) icv (8+-3 and 11+-3 mm Hg, respectively, vs. sham: 23+-3 and 21+-2 mm Hg) or carbachol (4 nmol/1 mul) icv (8+-2 and 21+-3 mm Hg, respectively, vs. sham: 33+-3 and 33+-3 mm Hg), without changing baseline arterial pressure.	Carbachol	148-157	angiotensinogen	Rattus norvegicus	51-57
21311027-8	2011	Furthermore, carbachol-induced expression of phospho-AKT (a marker of cholinergic response) was lost from day 35 CSMC in vitro, while retained in control cells.	Carbachol	13-22	AKT serine/threonine kinase 1	Rattus norvegicus	53-56
21212180-9	2011	Incubation with catalytically inactive PLD1, but not catalytically inactive mutant PLD2 adenovirus, also increased Cch-stimulated protein secretion and decreased ERK activity.	Carbachol	115-118	phospholipase D1	Rattus norvegicus	39-43
21713709-5	2011	RESULTS: In vitro, ghrelin enhanced the contraction of smooth muscle strips in the presence of carbachol, and the differences in contraction induced by different concentrations of ghrelin(0.1, 0.5, 1.0 mumol/L) were statistically significant [(223+-18)%, (245+-22)%, (264+-25)%, P&lt;0.01].	Carbachol	95-104	ghrelin and obestatin prepropeptide	Rattus norvegicus	19-26
20958290-9	2011	Carbachol affected both GDP association with and dissociation from G(i/o) G-proteins but only its dissociation from G(s/olf) G-proteins.	Carbachol	0-9	transmembrane O-mannosyltransferase targeting cadherins 1	Homo sapiens	120-123
21384922-10	2011	Phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) was increased in both carbachol-stimulated and epiphora glands.	Carbachol	92-101	mitogen-activated protein kinase 1	Homo sapiens	19-60
21384922-10	2011	Phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) was increased in both carbachol-stimulated and epiphora glands.	Carbachol	92-101	mitogen-activated protein kinase 3	Homo sapiens	62-68
21384922-11	2011	Preincubation of submandibular glands with ERK1/2 inhibitors PD98059 or U0126 inhibited carbachol-induced F-actin redistribution.	Carbachol	88-97	mitogen-activated protein kinase 3	Homo sapiens	43-49
21463572-7	2011	Carbachol stimulation releases Gbetagamma subunits from caveolae with a concurrent stabilization of activated Galpha(q) by caveolin-3 (Cav3).	Carbachol	0-9	caveolin 3	Canis lupus familiaris	123-133
21463572-7	2011	Carbachol stimulation releases Gbetagamma subunits from caveolae with a concurrent stabilization of activated Galpha(q) by caveolin-3 (Cav3).	Carbachol	0-9	caveolin 3	Canis lupus familiaris	135-139
21239638-12	2011	In conclusions, while Cx43(G60S/+) mice had severe AT/F, Cx40(-/-) mice were resistant to CCh-induced AT/F.	Carbachol	90-93	gap junction protein, alpha 5	Mus musculus	57-61
20082292-5	2011	Here we show that, in layer V of rat medial entorhinal cortex, muscarinic receptor-evoked plateau potentials and persistent firing induced by carbachol require phospholipase C activation, decrease of PIP(2) levels, and permissive intracellular Ca(2+) concentrations.	Carbachol	142-151	prolactin induced protein	Rattus norvegicus	200-203
21278382-7	2011	PCLS from Rgs5(-/-) mice contracted more to carbachol than those from WT mice, indicating that RGS5 negatively regulates bronchial smooth muscle contraction.	Carbachol	44-53	regulator of G-protein signaling 5	Mus musculus	10-14
21278382-7	2011	PCLS from Rgs5(-/-) mice contracted more to carbachol than those from WT mice, indicating that RGS5 negatively regulates bronchial smooth muscle contraction.	Carbachol	44-53	regulator of G-protein signaling 5	Mus musculus	95-99
21212180-10	2011	Inhibition of Rho with C3 exotoxin and a dominant negative Rho adenovirus and inhibition of ROCK with Y-27632 inhibited Cch-stimulated PLD1 activity, increased protein secretion, and decreased ERK activity.	Carbachol	120-123	phospholipase D1	Rattus norvegicus	135-139
21212180-10	2011	Inhibition of Rho with C3 exotoxin and a dominant negative Rho adenovirus and inhibition of ROCK with Y-27632 inhibited Cch-stimulated PLD1 activity, increased protein secretion, and decreased ERK activity.	Carbachol	120-123	Eph receptor B1	Rattus norvegicus	193-196
21212180-11	2011	The association of PLD1 and ROCK increased with Cch stimulation, as determined by immunoprecipitation.	Carbachol	48-51	phospholipase D1	Rattus norvegicus	19-23
20525722-4	2011	Carbachol increased MUC5AC mRNA and protein expression in human bronchus and cultured epithelial cells.	Carbachol	0-9	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	20-26
21081155-10	2011	Exposure to carbamylcholine decreased GDNF protein content to 51%+-28% of controls in the EDL but not SOL.	Carbachol	12-27	glial cell derived neurotrophic factor	Rattus norvegicus	38-42
20525722-5	2011	Aclidinium inhibited the carbachol-induced MUC5AC mRNA and protein expression with potency (half maximal inhibitory concentration) ~1 nM in human bronchus and cultured airway epithelial cells.	Carbachol	25-34	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	43-49
20525722-6	2011	AG1478, a selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, inhibited carbachol-induced MUC5AC responses, indicating EGFR transactivation.	Carbachol	100-109	epidermal growth factor receptor	Homo sapiens	33-65
20525722-6	2011	AG1478, a selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, inhibited carbachol-induced MUC5AC responses, indicating EGFR transactivation.	Carbachol	100-109	epidermal growth factor receptor	Homo sapiens	67-71
20525722-6	2011	AG1478, a selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, inhibited carbachol-induced MUC5AC responses, indicating EGFR transactivation.	Carbachol	100-109	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	118-124
20525722-6	2011	AG1478, a selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, inhibited carbachol-induced MUC5AC responses, indicating EGFR transactivation.	Carbachol	100-109	epidermal growth factor receptor	Homo sapiens	147-151
20525722-7	2011	Aclidinium inhibited carbachol-induced phospho-EGFR and phospho-p44/42 MAPK expression.	Carbachol	21-30	epidermal growth factor receptor	Homo sapiens	47-51
20525722-8	2011	In cultured airway epithelial cells transfected with small interfering (si)RNA against muscarinic receptor subtypes, siRNA-M3 but not siRNA-M2 blocked carbachol-induced MUC5AC expression.	Carbachol	151-160	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	169-175
21268094-6	2011	All the conditions known to modulate mTOR activity (IGF-1, wortmannin, rapamycin, PP242, and nutrient starvation) were shown to modify carbachol-induced Ca(2+) signaling in RINm5F cells.	Carbachol	135-144	mechanistic target of rapamycin kinase	Rattus norvegicus	37-41
21268094-6	2011	All the conditions known to modulate mTOR activity (IGF-1, wortmannin, rapamycin, PP242, and nutrient starvation) were shown to modify carbachol-induced Ca(2+) signaling in RINm5F cells.	Carbachol	135-144	insulin-like growth factor 1	Rattus norvegicus	52-57
21160001-8	2011	At the Schaffer-collateral synapse, bath application of the cholinergic agonist carbachol suppressed stratum radiatum-evoked excitatory postsynaptic potentials (EPSPs) in wild-type CA1 neurons and in CA1 neurons from mice lacking M1 or M2 receptors.	Carbachol	80-89	carbonic anhydrase 1	Mus musculus	200-203
21056967-8	2011	Treatment of H508 cells with carbachol, a hydrolytically stable acetylcholine analog, promoted H508 cell proliferation and activation of the mitogenic kinase, p90RSK.	Carbachol	29-38	ribosomal protein S6 kinase A1	Homo sapiens	159-165
21056967-9	2011	Small interfering RNA-mediated knockdown of Tmem147 expression significantly augmented the stimulatory effects of carbachol on H508 cell proliferation and p90RSK activation.	Carbachol	114-123	transmembrane protein 147	Homo sapiens	44-51
20939850-8	2011	Conditioned medium from CCh-pretreated cells mimicked its chronic antisecretory actions, suggesting involvement of an epithelial-derived soluble factor but further experimentation ruled out the involvement of epidermal growth factor receptor ligands.	Carbachol	24-27	epidermal growth factor receptor	Homo sapiens	209-241
21298058-2	2011	METHODOLOGY/PRINCIPAL FINDINGS: Here we examined carbachol-induced gamma oscillations in hippocampal slices lacking BDNF gene in the area CA3.	Carbachol	49-58	carbonic anhydrase 3	Mus musculus	138-141
21044662-4	2011	In the present study we examined the c-fos expression of these neurons after carbachol-induced active sleep (C-AS).	Carbachol	77-86	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	37-42
21030607-7	2011	The cholinergic agonist carbachol rapidly (within 10 min) reduced cell volume along the entire crypt/villus axis and promoted NHE3 internalization into early endosomes.	Carbachol	24-33	solute carrier family 9 member A3	Homo sapiens	126-130
21030607-8	2011	In contrast, carbachol induced membrane recruitment of NKCC1 and CFTR in all crypt and villus enterocytes, NKCC1 in all goblet cells, and NBCe1 in all villus enterocytes.	Carbachol	13-22	solute carrier family 12 member 2	Homo sapiens	55-60
21030607-8	2011	In contrast, carbachol induced membrane recruitment of NKCC1 and CFTR in all crypt and villus enterocytes, NKCC1 in all goblet cells, and NBCe1 in all villus enterocytes.	Carbachol	13-22	CF transmembrane conductance regulator	Homo sapiens	65-69
21030607-8	2011	In contrast, carbachol induced membrane recruitment of NKCC1 and CFTR in all crypt and villus enterocytes, NKCC1 in all goblet cells, and NBCe1 in all villus enterocytes.	Carbachol	13-22	solute carrier family 12 member 2	Homo sapiens	107-112
22178951-5	2011	Also, besides this last mutant was able to physically couple to Galpha(q/11) after carbachol challenge it was neither capable to activate phospholipase C nor phospholipase D. On the other hand, we demonstrated that the Asn-7.49 is important for the interaction between M(3)R and ARF1 and also for the formation of the ARF/Rho/beta gamma signaling complex, a complex that might determine the rapid activation and desensitization of PLD.	Carbachol	83-92	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	64-75
21160001-8	2011	At the Schaffer-collateral synapse, bath application of the cholinergic agonist carbachol suppressed stratum radiatum-evoked excitatory postsynaptic potentials (EPSPs) in wild-type CA1 neurons and in CA1 neurons from mice lacking M1 or M2 receptors.	Carbachol	80-89	carbonic anhydrase 1	Mus musculus	181-184
20851763-4	2011	Using serum starved SK-N-SH neuroblastoma cells, we show that the muscarinic receptor agonists carbachol and pilocarpine enhance the activation of the mTOR substrate p70 S6 Kinase (S6K) and its target ribosomal protein S6 (S6) in a VEGFR2 dependent manner.	Carbachol	95-104	mechanistic target of rapamycin kinase	Homo sapiens	151-155
20727967-4	2011	Pretreatment with the mTOR inhibitor rapamycin, decreased carbachol-induced Ca(2+) release in AR4-2J cells.	Carbachol	58-67	mechanistic target of rapamycin kinase	Rattus norvegicus	22-26
20727967-6	2011	We also showed that IGF-1 potentiates carbachol-induced Ca(2+) release in AR4-2J cells, an effect that was prevented by rapamycin.	Carbachol	38-47	insulin-like growth factor 1	Rattus norvegicus	20-25
20727967-7	2011	Rapamycin also decreased carbachol-induced Ca(2+) release in HEK 293A cells in which IP(3)R-1 and IP(3)R-3 had been knocked down.	Carbachol	25-34	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	85-93
20727967-7	2011	Rapamycin also decreased carbachol-induced Ca(2+) release in HEK 293A cells in which IP(3)R-1 and IP(3)R-3 had been knocked down.	Carbachol	25-34	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	98-106
21221778-4	2011	This study shows that treatment of the wild type HEK293 cells with low concentrations of carbachol (1-10 muM), an agonist of the muscarinic receptor, resulted in non-oscillated but sustained [Ca(2+)](i) increase by loading the cells with 1 muM fura2/AM.	Carbachol	89-98	latexin	Homo sapiens	105-108
21221778-4	2011	This study shows that treatment of the wild type HEK293 cells with low concentrations of carbachol (1-10 muM), an agonist of the muscarinic receptor, resulted in non-oscillated but sustained [Ca(2+)](i) increase by loading the cells with 1 muM fura2/AM.	Carbachol	89-98	latexin	Homo sapiens	240-243
20851763-4	2011	Using serum starved SK-N-SH neuroblastoma cells, we show that the muscarinic receptor agonists carbachol and pilocarpine enhance the activation of the mTOR substrate p70 S6 Kinase (S6K) and its target ribosomal protein S6 (S6) in a VEGFR2 dependent manner.	Carbachol	95-104	ribosomal protein S6 kinase B1	Homo sapiens	181-184
20851763-4	2011	Using serum starved SK-N-SH neuroblastoma cells, we show that the muscarinic receptor agonists carbachol and pilocarpine enhance the activation of the mTOR substrate p70 S6 Kinase (S6K) and its target ribosomal protein S6 (S6) in a VEGFR2 dependent manner.	Carbachol	95-104	ribosomal protein S6	Homo sapiens	201-221
20851763-4	2011	Using serum starved SK-N-SH neuroblastoma cells, we show that the muscarinic receptor agonists carbachol and pilocarpine enhance the activation of the mTOR substrate p70 S6 Kinase (S6K) and its target ribosomal protein S6 (S6) in a VEGFR2 dependent manner.	Carbachol	95-104	kinase insert domain receptor	Homo sapiens	232-238
20851763-5	2011	Treatments with carbachol increased VEGFR2 phosphorylation, suggesting that mAchRs stimulate VEGFR2 transactivation to enhance mTOR signaling.	Carbachol	16-25	kinase insert domain receptor	Homo sapiens	36-42
20851763-5	2011	Treatments with carbachol increased VEGFR2 phosphorylation, suggesting that mAchRs stimulate VEGFR2 transactivation to enhance mTOR signaling.	Carbachol	16-25	kinase insert domain receptor	Homo sapiens	93-99
20851763-5	2011	Treatments with carbachol increased VEGFR2 phosphorylation, suggesting that mAchRs stimulate VEGFR2 transactivation to enhance mTOR signaling.	Carbachol	16-25	mechanistic target of rapamycin kinase	Homo sapiens	127-131
21865666-8	2011	Similarly, EE increased phospholipase C activity in Ts65Dn mice, in response to carbachol and calcium.	Carbachol	80-89	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	52-58
20658540-2	2011	Recently, we showed that carbachol, an acetylcholine analog, stimulates contraction of C2C12 myotube cultures and the rapid arrival of myc-epitope tagged GLUT4 glucose transporters at the cell surface.	Carbachol	25-34	solute carrier family 2 member 4	Homo sapiens	154-159
20658540-4	2011	Cell surface carbachol-induced GLUT4myc levels were partly inhibited by the conventional/novel PKC inhibitors GF-109203X, Go6983, and Ro-31-8425 but not by the conventional PKC inhibitor Go6976.	Carbachol	13-22	solute carrier family 2 member 4	Homo sapiens	31-36
20658540-4	2011	Cell surface carbachol-induced GLUT4myc levels were partly inhibited by the conventional/novel PKC inhibitors GF-109203X, Go6983, and Ro-31-8425 but not by the conventional PKC inhibitor Go6976.	Carbachol	13-22	protein kinase C delta	Homo sapiens	95-98
20658540-6	2011	Carbachol stimulated phosphorylation of PKC isoforms and translocation of PKCdelta and PKCepsilon to membranes within 5 min.	Carbachol	0-9	protein kinase C delta	Homo sapiens	40-43
20658540-6	2011	Carbachol stimulated phosphorylation of PKC isoforms and translocation of PKCdelta and PKCepsilon to membranes within 5 min.	Carbachol	0-9	protein kinase C delta	Homo sapiens	74-82
20658540-6	2011	Carbachol stimulated phosphorylation of PKC isoforms and translocation of PKCdelta and PKCepsilon to membranes within 5 min.	Carbachol	0-9	protein kinase C epsilon	Homo sapiens	87-97
20658540-7	2011	However, only a peptidic inhibitor of PKCepsilon translocation (myristoylated-EAVSLKPT), but not one of PKCdelta (myristoylated-SFNSYELGSL), prevented the GLUT4myc response to carbachol.	Carbachol	176-185	solute carrier family 2 member 4	Homo sapiens	155-160
20658540-8	2011	Significant participation of PKCepsilon in the carbachol-induced gain of GLUT4myc at the surface of C2C12 myotubes was further supported through siRNA-mediated PKCepsilon protein knockdown.	Carbachol	47-56	solute carrier family 2 member 4	Homo sapiens	73-78
20658540-8	2011	Significant participation of PKCepsilon in the carbachol-induced gain of GLUT4myc at the surface of C2C12 myotubes was further supported through siRNA-mediated PKCepsilon protein knockdown.	Carbachol	47-56	protein kinase C epsilon	Homo sapiens	29-39
20961851-6	2010	Activation of the cells with carbachol increased the phosphorylation of TRPC6, an effect that was prevented by the inhibition of PKC.	Carbachol	29-38	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	72-77
20933560-7	2011	GLP-1 was without any effect in fundic strips, but it induced concentration-dependent relaxation in carbachol-precontracted antral strips.	Carbachol	100-109	glucagon	Mus musculus	0-5
21966394-13	2011	Interestingly, at the cellular signalling level, phosphorylation assays revealed abolished carbachol-triggered activation of ERK1/2 in mice lacking Galpha(i2).	Carbachol	91-100	mitogen-activated protein kinase 3	Mus musculus	125-131
21966394-13	2011	Interestingly, at the cellular signalling level, phosphorylation assays revealed abolished carbachol-triggered activation of ERK1/2 in mice lacking Galpha(i2).	Carbachol	91-100	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	148-157
20961851-6	2010	Activation of the cells with carbachol increased the phosphorylation of TRPC6, an effect that was prevented by the inhibition of PKC.	Carbachol	29-38	protein kinase C, gamma	Rattus norvegicus	129-132
21203481-4	2010	Here, this principle is demonstrated for analysis of a G-protein coupled receptor system, the M3 muscarinic receptor-calcium signaling pathway, using microfluidic-mediated periodic chemical stimulation of the M3 receptor with carbachol and real-time imaging of resulting calcium transients.	Carbachol	226-235	cholinergic receptor muscarinic 3	Homo sapiens	94-116
20816837-9	2010	Based on previous reports that Ca(2+)(i) release also stimulates acid secretion in parietal cells, we showed that gadolinium-, thapsigargin-, and carbachol-mediated release of Ca(2+)(i) induced Shh expression.	Carbachol	146-155	sonic hedgehog	Mus musculus	194-197
20671279-10	2010	Incubation with dbcAMP did not have any effect either on the EGF receptor or on Ras but significantly inhibited both basal and Raf-1 and MEK activity stimulated with Cch or EGF.	Carbachol	166-169	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	127-132
20863867-5	2010	The concentration-contraction curves to carbachol (CCh) were shifted to the left in the presence of Ang II.	Carbachol	40-49	angiotensinogen	Rattus norvegicus	100-106
20938046-5	2010	Application of the muscarinic agonist carbachol to the cells caused a rapid, time-dependent decrease in the fluorescent signal, indicative of K(+) efflux through the GIRK1/4 channel (carbachol vs. control solution, Z" factor = 0.5-0.6).	Carbachol	38-47	potassium inwardly-rectifying channel, subfamily J, member 3	Mus musculus	166-171
20938046-5	2010	Application of the muscarinic agonist carbachol to the cells caused a rapid, time-dependent decrease in the fluorescent signal, indicative of K(+) efflux through the GIRK1/4 channel (carbachol vs. control solution, Z" factor = 0.5-0.6).	Carbachol	183-192	potassium inwardly-rectifying channel, subfamily J, member 3	Mus musculus	166-171
20863867-5	2010	The concentration-contraction curves to carbachol (CCh) were shifted to the left in the presence of Ang II.	Carbachol	51-54	angiotensinogen	Rattus norvegicus	100-106
20863867-6	2010	The maximal contraction of CCh was also significantly increased by pretreatment with Ang II.	Carbachol	27-30	angiotensinogen	Rattus norvegicus	85-91
20976005-5	2010	Treatment of cells with the agonist carbachol disrupted the interaction of RACK1 with M(2).	Carbachol	36-45	receptor for activated C kinase 1	Homo sapiens	75-80
20805306-3	2010	In the guinea pig isolated trachea and human isolated bronchus, CHF5407 produced a potent (pIC(50) = 9.0-9.6) and long-lasting (up to 24 h) inhibition of M3 receptor-mediated contractile responses to carbachol.	Carbachol	200-209	cholinergic receptor muscarinic 3	Homo sapiens	154-156
20805306-4	2010	In the guinea pig electrically driven left atrium, the M2 receptor-mediated inhibitory response to carbachol was recovered more quickly in CHF5407-pretreated than in tiotropium-pretreated preparations.	Carbachol	99-108	cholinergic receptor muscarinic 2	Homo sapiens	55-57
20864673-7	2010	Loss of RGS6 provoked dramatically exaggerated bradycardia in response to carbachol in mice and isolated perfused hearts and significantly enhanced the effect of carbachol on inhibition of spontaneous action potential firing in sinoatrial node cells.	Carbachol	74-83	regulator of G-protein signaling 6	Mus musculus	8-12
20864673-7	2010	Loss of RGS6 provoked dramatically exaggerated bradycardia in response to carbachol in mice and isolated perfused hearts and significantly enhanced the effect of carbachol on inhibition of spontaneous action potential firing in sinoatrial node cells.	Carbachol	162-171	regulator of G-protein signaling 6	Mus musculus	8-12
20876203-11	2010	Following TTX application, carbachol (1 muM), substance P (1 muM) and an NKI agonist (GR73632, 100 nM) produced the fast oscillations superimposed on a slow increase in Ca(2+) in ICC-MY, whereas SNP (an NO donor, 10 muM) abolished all activity in ICC-MY.	Carbachol	27-36	latexin	Homo sapiens	40-43
20413533-0	2010	FIZZ1 potentiates the carbachol-induced tracheal smooth muscle contraction.	Carbachol	22-31	resistin like alpha	Mus musculus	0-5
20495491-3	2010	RESULTS: The results indicated that PKCalpha and epsilon agonists, thymelea toxin and carbachol, restored shock-induced decrease of vascular calcium sensitivity; PKCalpha antagonist, Go-6976 and PKCepsilon pseudosubstrate inhibition peptide, aggravated shock-induced calcium desensitization, whereas the agonists and antagonists of PKCdelta and zeta had no effects on shock-induced calcium desensitization.	Carbachol	86-95	protein kinase C, alpha	Rattus norvegicus	36-44
20495491-3	2010	RESULTS: The results indicated that PKCalpha and epsilon agonists, thymelea toxin and carbachol, restored shock-induced decrease of vascular calcium sensitivity; PKCalpha antagonist, Go-6976 and PKCepsilon pseudosubstrate inhibition peptide, aggravated shock-induced calcium desensitization, whereas the agonists and antagonists of PKCdelta and zeta had no effects on shock-induced calcium desensitization.	Carbachol	86-95	protein kinase C, alpha	Rattus norvegicus	162-170
20648635-4	2010	As M(3) muscarinic receptor signaling in astroglial cells is strongly inhibited by ethanol, we hypothesized that ethanol may also inhibit neuritogenesis in hippocampal neurons induced by carbachol-stimulated astrocytes.	Carbachol	187-196	cholinergic receptor muscarinic 3	Homo sapiens	3-27
20573995-6	2010	Only knockdown of RGS11 increased both carbachol-mediated calcium mobilization and inositol phosphate accumulation.	Carbachol	39-48	regulator of G protein signaling 11	Homo sapiens	18-23
20573995-7	2010	Surprisingly, we found that knockdown of RGS8 and RGS9, but not other conventional RGS proteins, significantly decreased carbachol-mediated calcium mobilization, whereas only RGS8 knockdown decreased protease-activated receptor-1 (PAR-1)-mediated calcium mobilization.	Carbachol	121-130	regulator of G protein signaling 8	Homo sapiens	41-45
20573995-7	2010	Surprisingly, we found that knockdown of RGS8 and RGS9, but not other conventional RGS proteins, significantly decreased carbachol-mediated calcium mobilization, whereas only RGS8 knockdown decreased protease-activated receptor-1 (PAR-1)-mediated calcium mobilization.	Carbachol	121-130	regulator of G protein signaling 9	Homo sapiens	50-54
20573995-7	2010	Surprisingly, we found that knockdown of RGS8 and RGS9, but not other conventional RGS proteins, significantly decreased carbachol-mediated calcium mobilization, whereas only RGS8 knockdown decreased protease-activated receptor-1 (PAR-1)-mediated calcium mobilization.	Carbachol	121-130	paired like homeodomain 2	Homo sapiens	41-44
20573995-8	2010	Loss of responsiveness toward carbachol and PAR-1 agonist peptide upon RGS8 knockdown appears due, at least in part, to a loss in respective receptor cell surface expression, although this is not the case for RGS9 knockdown.	Carbachol	30-39	regulator of G protein signaling 8	Homo sapiens	71-75
20573995-9	2010	Our data suggest a cellular role for RGS8 in the stable surface expression of M3 muscarinic acetylcholine receptor and PAR-1, as well as a specific and opposing set of functions for RGS9 and RGS11 in modulating carbachol responsiveness similar to that seen in Caenorhabditis elegans.	Carbachol	211-220	Regulator of G-protein signaling rgs-9	Caenorhabditis elegans	182-186
20573995-9	2010	Our data suggest a cellular role for RGS8 in the stable surface expression of M3 muscarinic acetylcholine receptor and PAR-1, as well as a specific and opposing set of functions for RGS9 and RGS11 in modulating carbachol responsiveness similar to that seen in Caenorhabditis elegans.	Carbachol	211-220	Regulator of G-protein signaling rgs-11	Caenorhabditis elegans	191-196
20375347-0	2010	Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells.	Carbachol	14-23	lacritin	Homo sapiens	45-53
20375347-10	2010	The cholinergic agonist carbachol (Cch) stimulated the secretion of lacritin and increased intracellular Ca2+.	Carbachol	24-33	lacritin	Homo sapiens	68-76
20375347-10	2010	The cholinergic agonist carbachol (Cch) stimulated the secretion of lacritin and increased intracellular Ca2+.	Carbachol	35-38	lacritin	Homo sapiens	68-76
20375347-11	2010	Cch-induced lacritin secretion was inhibited by the store-operated calcium (SOC) channel inhibitor YM58483 and the PKC inhibitors GF109203 and Ro-32-0432.	Carbachol	0-3	lacritin	Homo sapiens	12-20
20375347-12	2010	Cch-induced lacritin secretion was not inhibited by MAPKK inhibitor U0126, although p42/p44 MAPK was phosphorylated.	Carbachol	0-3	lacritin	Homo sapiens	12-20
20375347-12	2010	Cch-induced lacritin secretion was not inhibited by MAPKK inhibitor U0126, although p42/p44 MAPK was phosphorylated.	Carbachol	0-3	cyclin dependent kinase 20	Homo sapiens	84-87
20375347-12	2010	Cch-induced lacritin secretion was not inhibited by MAPKK inhibitor U0126, although p42/p44 MAPK was phosphorylated.	Carbachol	0-3	mitogen-activated protein kinase 3	Homo sapiens	88-96
20375347-15	2010	Induction of transcription by Cch involved the independent p42/p44 MAPK and PKC pathways.	Carbachol	30-33	cyclin dependent kinase 20	Homo sapiens	59-62
20375347-15	2010	Induction of transcription by Cch involved the independent p42/p44 MAPK and PKC pathways.	Carbachol	30-33	interferon induced protein 44	Homo sapiens	63-66
20375347-15	2010	Induction of transcription by Cch involved the independent p42/p44 MAPK and PKC pathways.	Carbachol	30-33	mitogen-activated protein kinase 3	Homo sapiens	67-71
20871620-0	2010	Carbachol inhibits TNF-alpha-induced endothelial barrier dysfunction through alpha 7 nicotinic receptors.	Carbachol	0-9	tumor necrosis factor	Rattus norvegicus	19-28
20871620-6	2010	RESULTS: Carbachol (2 mumol/L-2 mmol/L) prevented increase in endothelial cell permeability induced by TNF-alpha (500 ng/mL) in a dose-dependent manner.	Carbachol	9-18	tumor necrosis factor	Rattus norvegicus	103-112
20871620-8	2010	In addition, treatment of endothelial cells with carbachol decreased phosphor-ERK1/2 and phosphor-JNK.	Carbachol	49-58	mitogen activated protein kinase 3	Rattus norvegicus	78-84
20871620-8	2010	In addition, treatment of endothelial cells with carbachol decreased phosphor-ERK1/2 and phosphor-JNK.	Carbachol	49-58	mitogen-activated protein kinase 8	Rattus norvegicus	98-101
20871620-10	2010	CONCLUSION: These data suggest that the inhibitory effect of carbachol on TNF-alpha-induced endothelial barrier dysfunction mediated by the alpha 7 nicotinic receptor.	Carbachol	61-70	tumor necrosis factor	Rattus norvegicus	74-83
20689057-7	2010	As a functional consequence, loss of PTPN2 potentiated EGF-induced inhibition of carbachol-stimulated Ca(2+)-dependent Cl(-) secretion.	Carbachol	81-90	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	37-42
20693290-11	2010	Carbachol increased the probability of SR input to drive action potential firing in CA1 pyramidal neurons, which was inhibited by SLM prepulses (150-225 ms).	Carbachol	0-9	carbonic anhydrase 1	Rattus norvegicus	84-87
19783789-9	2010	In vitro incubation with IL-13, but not TGF-beta(1), induced changes in small airway sensitivity to CCh and 5HT.	Carbachol	100-103	interleukin 13	Rattus norvegicus	25-30
20643770-9	2010	ATP and carbachol increased intracellular Ca(2+) activity, but responses depended on the gland type, presence of the P2X(7) receptor and the sex of the animal.	Carbachol	8-17	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	117-132
20505521-8	2010	Pioglitazone (PPAR gamma agonist, 10 microM) abolished the CSA-induced attenuation of carbachol responses, an effect that was not manifest in presence of GW9662 or l-NAME.	Carbachol	86-95	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	14-24
20505521-10	2010	More importantly, NOS signaling downstream of PPAR gamma mediates, at least partly, the inhibitory effect of CSA on carbachol vasodilations.	Carbachol	116-125	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	46-56
20547680-6	2010	Intriguingly, however, we found that bath application of the GAT-1 transport blocker NO-711 (1 mum) produces inhibition of evoked IPSCs that is reversed by CGP52432, and that lower doses of CCh produce inhibition with greater CGP52432 sensitivity.	Carbachol	190-193	solute carrier family 6 member 12	Rattus norvegicus	61-66
20495822-5	2010	The contractions induced by carbachol (CCh), high K(+) depolarization, and sodium fluoride (NaF; a G protein activator) were augmented by pretreatment with Ang II.	Carbachol	28-37	angiotensinogen	Rattus norvegicus	156-162
20495822-5	2010	The contractions induced by carbachol (CCh), high K(+) depolarization, and sodium fluoride (NaF; a G protein activator) were augmented by pretreatment with Ang II.	Carbachol	39-42	angiotensinogen	Rattus norvegicus	156-162
20495822-7	2010	Furthermore, the Ang II-induced BSM hyperresponsiveness to CCh was attenuated by pretreatment with U-0126, a p42/44 ERK kinase (MEK-1/2) inhibitor.	Carbachol	59-62	angiotensinogen	Rattus norvegicus	17-23
20495822-7	2010	Furthermore, the Ang II-induced BSM hyperresponsiveness to CCh was attenuated by pretreatment with U-0126, a p42/44 ERK kinase (MEK-1/2) inhibitor.	Carbachol	59-62	Eph receptor B1	Rattus norvegicus	116-119
20495822-7	2010	Furthermore, the Ang II-induced BSM hyperresponsiveness to CCh was attenuated by pretreatment with U-0126, a p42/44 ERK kinase (MEK-1/2) inhibitor.	Carbachol	59-62	mitogen activated protein kinase kinase 1	Rattus norvegicus	128-135
20398705-5	2010	In addition, the same peptide was able to abrogate the carbachol-induced mitogen-activated protein kinase phosphorylation and the carbachol-enhanced PHA-induced IL-2 production in derived lymphocytic T cells.	Carbachol	130-139	interleukin 2	Homo sapiens	161-165
19655318-3	2010	Interestingly, such neural responses in CA1 are also elicited by microinjection of the cholinergic agonist carbachol into the hypothalamic supramammillary nucleus (SuM).	Carbachol	107-116	carbonic anhydrase 1	Rattus norvegicus	40-43
19655318-5	2010	Pharmacological investigation showed that intra-SuM microinjection of either a muscarinic or a nicotinic receptor antagonist attenuated the SuM carbachol-induced neural effects in CA1, namely, theta activation and PS suppression.	Carbachol	144-153	carbonic anhydrase 1	Rattus norvegicus	180-183
20739756-8	2010	First, CFTR-dependent secretion was strongly potentiated by low VIP and carbachol concentrations that individually were unable to stimulate secretion.	Carbachol	72-81	CF transmembrane conductance regulator	Homo sapiens	7-11
20371628-7	2010	Both carbachol and PDBu increased Ca(V)1.2 channel currents in isolated bladder myocytes.	Carbachol	5-14	calcium channel, voltage-dependent, L type, alpha 1C subunit	Mus musculus	34-42
20371628-8	2010	Blue native-PAGE electrophoresis revealed that Ca(V)1.2, PKC, and PLD are closely associated in muscles being previously stimulated by carbachol.	Carbachol	135-144	calcium channel, voltage-dependent, L type, alpha 1C subunit	Mus musculus	47-55
20505521-6	2010	The carbachol-induced renal vasodilations were also reduced after infusion of N-nitro-L-arginine methyl ester (L-NAME, NOS inhibitor, 100 microM) or 2-chloro-5-nitro-N-phenylbenzamide (GW9662, PPAR gamma antagonist, 1 microM).	Carbachol	4-13	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	193-203
20505129-0	2010	Carbachol-induced long-term synaptic depression is enhanced during senescence at hippocampal CA3-CA1 synapses.	Carbachol	0-9	carbonic anhydrase 3	Rattus norvegicus	93-100
20478977-3	2010	Prostaglandin E(2) (PGE(2))- and carbachol-stimulated mucus release was severely inhibited in the absence of serosal HCO(3)(-), HCO(3)(-) transport, or functional cystic fibrosis transmembrane conductance regulator (CFTR).	Carbachol	33-42	CF transmembrane conductance regulator	Homo sapiens	163-214
20478977-3	2010	Prostaglandin E(2) (PGE(2))- and carbachol-stimulated mucus release was severely inhibited in the absence of serosal HCO(3)(-), HCO(3)(-) transport, or functional cystic fibrosis transmembrane conductance regulator (CFTR).	Carbachol	33-42	CF transmembrane conductance regulator	Homo sapiens	216-220
20421298-11	2010	Consistent with this, carbachol potentiated GIP-mediated insulin release from in situ perfused pancreata of GIP/DT mice.	Carbachol	22-31	gastric inhibitory polypeptide	Mus musculus	44-47
20592220-8	2010	In mice with recurrent seizures, carbachol-induced enhancement of spontaneous IPSCs (sIPSCs) originating from CCK-containing basket cells was accordingly reduced in CA1 pyramidal cells.	Carbachol	33-42	cholecystokinin	Mus musculus	110-113
20592220-8	2010	In mice with recurrent seizures, carbachol-induced enhancement of spontaneous IPSCs (sIPSCs) originating from CCK-containing basket cells was accordingly reduced in CA1 pyramidal cells.	Carbachol	33-42	carbonic anhydrase 1	Mus musculus	165-168
20592220-9	2010	By suppressing sIPSCs from CCK-expressing basket cells, a CB(1) agonist reverted the stimulatory effects of carbachol in naive mice to levels comparable with those observed in cells from epileptic mice.	Carbachol	108-117	cholecystokinin	Mus musculus	27-30
20592220-9	2010	By suppressing sIPSCs from CCK-expressing basket cells, a CB(1) agonist reverted the stimulatory effects of carbachol in naive mice to levels comparable with those observed in cells from epileptic mice.	Carbachol	108-117	cannabinoid receptor 1 (brain)	Mus musculus	58-63
21117404-6	2010	PKG also decreased stimulated NO production: acetylcholine produced raw fluorescence of 59999 +/- 702 and in the presence of 1 mM 8-Br-cGMP the value was 20645 +/- 292 (p &lt; 0.0001) while carbachol produced raw fluorescence of 60600 +/- 890 and in the presence of 1 mM 8-Br-cGMP was 30442 +/- 2000 (p &lt; 0.01).	Carbachol	190-199	protein kinase cGMP-dependent 1	Homo sapiens	0-3
20421298-11	2010	Consistent with this, carbachol potentiated GIP-mediated insulin release from in situ perfused pancreata of GIP/DT mice.	Carbachol	22-31	gastric inhibitory polypeptide	Mus musculus	108-111
20572856-6	2010	Inhibition of TRPV4 with ruthenium red impaired both ATP- and carbachol-stimulated Ca(2+) signals.	Carbachol	62-71	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	14-19
20572856-9	2010	Furthermore, even though Ca(2+) signals were not needed for this volume regulation, TRPV4 seems to play a role during ATP and carbachol stimulation.	Carbachol	126-135	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	84-89
20390293-5	2010	TRPC5 activity could be evoked by carbachol acting at muscarinic receptors, lanthanum, or a reducing agent.	Carbachol	34-43	transient receptor potential cation channel subfamily C member 5	Homo sapiens	0-5
20159855-3	2010	Carbachol (an acetylcholine receptor agonist) induced a gain in cell surface GLUT4myc that was mediated by nicotinic acetylcholine receptors.	Carbachol	0-9	solute carrier family 2 member 4	Homo sapiens	77-82
20159855-5	2010	The gain in surface GLUT4myc elicited by carbachol or by the AMPK activator 5-amino-4-carboxamide-1 beta-ribose was sensitive to chemical inhibition of AMPK activity by compound C and partially reduced by siRNA-mediated knockdown of AMPK catalytic subunits or LKB1.	Carbachol	41-50	solute carrier family 2 member 4	Homo sapiens	20-25
20159855-5	2010	The gain in surface GLUT4myc elicited by carbachol or by the AMPK activator 5-amino-4-carboxamide-1 beta-ribose was sensitive to chemical inhibition of AMPK activity by compound C and partially reduced by siRNA-mediated knockdown of AMPK catalytic subunits or LKB1.	Carbachol	41-50	serine/threonine kinase 11	Homo sapiens	260-264
20159855-6	2010	In addition, the carbachol-induced gain in cell surface GLUT4myc was partially sensitive to chelation of intracellular calcium with BAPTA-AM.	Carbachol	17-26	solute carrier family 2 member 4	Homo sapiens	56-61
20159855-7	2010	However, the carbachol-induced gain in cell surface GLUT4myc was not sensitive to the CaMKK inhibitor STO-609 despite expression of both isoforms of this enzyme and a rise in cytosolic calcium by carbachol.	Carbachol	13-22	solute carrier family 2 member 4	Homo sapiens	52-57
20159855-8	2010	Therefore, separate AMPK- and calcium-dependent signals contribute to mobilizing GLUT4 in response to carbachol, providing an in vitro cell model that recapitulates the two major signals whereby acute contraction regulates glucose uptake in skeletal muscle.	Carbachol	102-111	solute carrier family 2 member 4	Homo sapiens	81-86
20203064-7	2010	Moreover, pretreatment of T(84) cells with leptin for up to 1 h significantly potentiated carbachol- and forskolin-induced increases in I(sc).	Carbachol	90-99	leptin	Rattus norvegicus	43-49
20203064-8	2010	Pretreatment with an inhibitor of MAPK abolished the effect of leptin on basal, carbachol- and forskolin-induced chloride secretion (P &lt; 0.05).	Carbachol	80-89	leptin	Rattus norvegicus	63-69
20233329-10	2010	Furthermore, carbachol directly increased the mRNA expression of AQP5 and phosphorylation of ERK1/2 in cultured neonatal rabbit SMG cells.	Carbachol	13-22	aquaporin-5	Oryctolagus cuniculus	65-69
20229195-10	2010	Twenty-minute incubation with hBD-2 increased the CCh-induced Ca(2+) transient by 20-30% compared to either vehicle-treated cells or cells treated with the defensins hBD-1, hBD-3, or HD-5.	Carbachol	50-53	defensin beta 4A	Homo sapiens	30-35
20229195-10	2010	Twenty-minute incubation with hBD-2 increased the CCh-induced Ca(2+) transient by 20-30% compared to either vehicle-treated cells or cells treated with the defensins hBD-1, hBD-3, or HD-5.	Carbachol	50-53	defensin beta 1	Homo sapiens	166-171
20229195-10	2010	Twenty-minute incubation with hBD-2 increased the CCh-induced Ca(2+) transient by 20-30% compared to either vehicle-treated cells or cells treated with the defensins hBD-1, hBD-3, or HD-5.	Carbachol	50-53	defensin beta 103B	Homo sapiens	173-178
20138847-3	2010	One such mouse is the GAD67-GFP (Deltaneo), and here we compare the properties of kainate- and carbachol-induced oscillatory activity generated in CA3 of hippocampal slices from heterozygous GAD67-GFP (Deltaneo) mice and wild type litter mates.	Carbachol	95-104	carbonic anhydrase 3	Mus musculus	147-150
20061444-3	2010	We have investigated the relaxation of carbachol-contracted mouse tracheal segments to the beta(2)AR agonists formoterol, terbutaline, and salmeterol.	Carbachol	39-48	adrenergic receptor, beta 2	Mus musculus	91-100
20399743-5	2010	In these cells optimal activation of endogenous Galphaq by expressing M3-muscarinic acetylcholine receptor (with or without carbachol treatment), or exposing the cells to thrombin led to an increase of 2 to 3-fold in endogenous cytoplasmic beta-Catenin protein levels.	Carbachol	124-133	coagulation factor II, thrombin	Homo sapiens	171-179
20543478-1	2010	OBJECTIVE: To investigate the regulation of atropine to the expression and secretion of TGF-beta2 in retinal pigment epithelium (RPE) cells by observing the changes of those under different treatments of atropine and carbachol.	Carbachol	217-226	transforming growth factor beta 2	Homo sapiens	88-97
20543478-9	2010	CONCLUSION: Carbachol can promote the expression and secretion of TGF-beta2 in human RPE cells and atropine could reverse it effectively, suggesting that M receptor may be involved.	Carbachol	12-21	transforming growth factor beta 2	Homo sapiens	66-75
20207737-3	2010	Here we report that the beta-adrenergic ligand isoproterenol blocks increases in extracellular signal-related kinase (ERK) phosphorylation, a protein kinase C-dependent event promoted by the muscarinic receptor ligand carbachol in freshly dispersed rat parotid acinar cells.	Carbachol	218-227	Eph receptor B1	Rattus norvegicus	81-116
20207737-3	2010	Here we report that the beta-adrenergic ligand isoproterenol blocks increases in extracellular signal-related kinase (ERK) phosphorylation, a protein kinase C-dependent event promoted by the muscarinic receptor ligand carbachol in freshly dispersed rat parotid acinar cells.	Carbachol	218-227	Eph receptor B1	Rattus norvegicus	118-121
20172859-5	2010	Elevation of intracellular calcium by ionomycin treatment, or activation of acetylcholine receptor or epidermal growth factor receptor by carbachol or epidermal growth factor stimulation induced activation of endogenous Nedd4 in vivo evaluated by assays of either Nedd4 E3 ligase activity or ubiquitination of Nedd4 substrate ENaC-beta.	Carbachol	138-147	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	220-225
19666830-5	2010	Activation of phospholipase C (PLC), protein kinase C (PKC), and postsynaptic Ca(2+) release from inositol 1,4,5-triphosphate (IP(3)) receptor-sensitive internal stores are required for CCh-LTD induction.	Carbachol	186-189	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	127-142
19666830-7	2010	CCh-LTD is blocked by nitric oxide (NO) synthase inhibitors, soluble guanylyl cyclase (sGC) inhibitor, and protein kinase G (PKG) inhibitor.	Carbachol	0-3	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	61-85
19666830-7	2010	CCh-LTD is blocked by nitric oxide (NO) synthase inhibitors, soluble guanylyl cyclase (sGC) inhibitor, and protein kinase G (PKG) inhibitor.	Carbachol	0-3	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	87-90
20012300-0	2010	Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats.	Carbachol	0-9	transforming growth factor alpha	Rattus norvegicus	18-27
20234002-3	2010	We found that ankyrin-B-deficient islets displayed impaired potentiation of insulin secretion by the muscarinic agonist carbachol, blunted carbachol-mediated intracellular Ca2+ release, and reduced the abundance of IP3R.	Carbachol	120-129	ankyrin 2, brain	Mus musculus	14-23
20234002-3	2010	We found that ankyrin-B-deficient islets displayed impaired potentiation of insulin secretion by the muscarinic agonist carbachol, blunted carbachol-mediated intracellular Ca2+ release, and reduced the abundance of IP3R.	Carbachol	139-148	ankyrin 2, brain	Mus musculus	14-23
20012300-3	2010	The aim of our present study was to determine the effects of carbachol on mucosal TGFalpha expression and epithelial cell proliferation in vivo.	Carbachol	61-70	transforming growth factor alpha	Rattus norvegicus	82-90
20012300-7	2010	RESULTS: Carbachol induced a significant increase in mucosal epithelial cell proliferation and TGFalpha expression.	Carbachol	9-18	transforming growth factor alpha	Rattus norvegicus	95-103
20136837-8	2010	The rate of NTUA accumulation was slower in the presence of the muscarinic agonist carbachol (10 microM) demonstrating muscarinic inhibition of NET rate.	Carbachol	83-92	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	144-147
19923416-9	2010	Carbachol increased RBF and decreased MAP in SMTC-treated rats, whereas it had no effect in L-NAME-treated rats, indicating that SMTC selectively inhibited NOS1.	Carbachol	0-9	nitric oxide synthase 1	Rattus norvegicus	156-160
19823767-2	2010	In this work, we investigate the action of the muscarinic agonist carbachol (CARB) on the expression and function of nitric oxide synthase (NOS) and cyclooxygenase (COX) in fibroblasts under normal or inflammatory conditions.	Carbachol	66-75	nitric oxide synthase 1, neuronal	Mus musculus	117-138
19823767-2	2010	In this work, we investigate the action of the muscarinic agonist carbachol (CARB) on the expression and function of nitric oxide synthase (NOS) and cyclooxygenase (COX) in fibroblasts under normal or inflammatory conditions.	Carbachol	77-81	nitric oxide synthase 1, neuronal	Mus musculus	117-138
19823767-9	2010	CARB also upregulated NOS1 protein expression via NF-kappaB activation.	Carbachol	0-4	nitric oxide synthase 1, neuronal	Mus musculus	22-26
19823767-9	2010	CARB also upregulated NOS1 protein expression via NF-kappaB activation.	Carbachol	0-4	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	50-59
19823767-10	2010	In addition CARB and LPS plus IFNgamma stimulated PGE(2) synthesis by 72 +/- 9 and 42 +/- 4%, respectively, while CARB added to LPS plus IFNgamma treated cells produced a synergism in PGE(2) liberation (130 +/- 12%) via COX-2.	Carbachol	114-118	cytochrome c oxidase II, mitochondrial	Mus musculus	220-225
19763792-1	2010	Previous studies on MCF-7 breast cancer cells have shown that the G-protein coupled receptor (GPCR) agonist carbachol increases intracellular calcium levels and the activation of extracellular signal-regulated kinase (ERK).	Carbachol	108-117	C-X-C motif chemokine receptor 6	Homo sapiens	66-92
19763792-1	2010	Previous studies on MCF-7 breast cancer cells have shown that the G-protein coupled receptor (GPCR) agonist carbachol increases intracellular calcium levels and the activation of extracellular signal-regulated kinase (ERK).	Carbachol	108-117	C-X-C motif chemokine receptor 6	Homo sapiens	94-98
19763792-1	2010	Previous studies on MCF-7 breast cancer cells have shown that the G-protein coupled receptor (GPCR) agonist carbachol increases intracellular calcium levels and the activation of extracellular signal-regulated kinase (ERK).	Carbachol	108-117	mitogen-activated protein kinase 1	Homo sapiens	179-216
19763792-1	2010	Previous studies on MCF-7 breast cancer cells have shown that the G-protein coupled receptor (GPCR) agonist carbachol increases intracellular calcium levels and the activation of extracellular signal-regulated kinase (ERK).	Carbachol	108-117	mitogen-activated protein kinase 1	Homo sapiens	218-221
19763792-3	2010	Our results suggest that both estrogen (E2) and carbachol treatment of MCF-7 breast cancer cells trigger phosphorylation of ERK1/2 and the transcription factor Elk-1.	Carbachol	48-57	mitogen-activated protein kinase 3	Homo sapiens	124-130
19763792-3	2010	Our results suggest that both estrogen (E2) and carbachol treatment of MCF-7 breast cancer cells trigger phosphorylation of ERK1/2 and the transcription factor Elk-1.	Carbachol	48-57	ETS transcription factor ELK1	Homo sapiens	160-165
19763792-5	2010	Carbachol-stimulated ERK activation and cell growth was completely blocked by the Muscarinic M(3)-subtype GPCR inhibitor, 4-DAMP, and siRNA against the M(3)-subtype GPCR.	Carbachol	0-9	mitogen-activated protein kinase 1	Homo sapiens	21-24
19763792-5	2010	Carbachol-stimulated ERK activation and cell growth was completely blocked by the Muscarinic M(3)-subtype GPCR inhibitor, 4-DAMP, and siRNA against the M(3)-subtype GPCR.	Carbachol	0-9	C-X-C motif chemokine receptor 6	Homo sapiens	106-110
19763792-5	2010	Carbachol-stimulated ERK activation and cell growth was completely blocked by the Muscarinic M(3)-subtype GPCR inhibitor, 4-DAMP, and siRNA against the M(3)-subtype GPCR.	Carbachol	0-9	C-X-C motif chemokine receptor 6	Homo sapiens	165-169
19763792-6	2010	Interestingly, blockade of CaM KK with the selective inhibitor STO-609 prevented carbachol activation CaM KI, ERK, Elk-1, and cell growth.	Carbachol	81-90	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	27-33
19763792-6	2010	Interestingly, blockade of CaM KK with the selective inhibitor STO-609 prevented carbachol activation CaM KI, ERK, Elk-1, and cell growth.	Carbachol	81-90	ETS transcription factor ELK1	Homo sapiens	115-120
19763792-7	2010	Consistent with these observations, knockdown of CaM KKalpha and CaM KIgamma with shRNA-containing plasmids blocked ERK activation by carbachol.	Carbachol	134-143	mitogen-activated protein kinase 1	Homo sapiens	116-119
19763792-8	2010	In addition, Elk-1 phosphorylation and luciferase activity in response to carbachol treatment was also dependent upon CaM kinases and was inhibited by U0126, STO-609, and siRNA knockdown of CaM kinases and ERK2.	Carbachol	74-83	ETS transcription factor ELK1	Homo sapiens	13-18
19763792-8	2010	In addition, Elk-1 phosphorylation and luciferase activity in response to carbachol treatment was also dependent upon CaM kinases and was inhibited by U0126, STO-609, and siRNA knockdown of CaM kinases and ERK2.	Carbachol	74-83	mitogen-activated protein kinase 1	Homo sapiens	206-210
19763792-9	2010	Finally, blockade of either CaM KK (with STO-609) or ERK (with U0126) activities resulted in the inhibition of carbachol- and estrogen-mediated cyclin D1 expression and MCF-7 cell growth.	Carbachol	111-120	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	28-34
19763792-9	2010	Finally, blockade of either CaM KK (with STO-609) or ERK (with U0126) activities resulted in the inhibition of carbachol- and estrogen-mediated cyclin D1 expression and MCF-7 cell growth.	Carbachol	111-120	mitogen-activated protein kinase 1	Homo sapiens	53-56
19763792-9	2010	Finally, blockade of either CaM KK (with STO-609) or ERK (with U0126) activities resulted in the inhibition of carbachol- and estrogen-mediated cyclin D1 expression and MCF-7 cell growth.	Carbachol	111-120	cyclin D1	Homo sapiens	144-153
19864322-3	2010	We previously showed that activation of protein kinase C (PKC) by carbachol and phorbol 12-myristate 13-acetate (PMA) decreases NKCC1 surface expression in T84 cells.	Carbachol	66-75	solute carrier family 12 member 2	Homo sapiens	128-133
19763792-10	2010	Taken together, our results suggest that carbachol treatment of MCF-7 cells activates CaM KI, ERK, the transcription factor Elk-1, cyclin D1, and cell growth through CaM KK.	Carbachol	41-50	mitogen-activated protein kinase 1	Homo sapiens	94-97
19763792-10	2010	Taken together, our results suggest that carbachol treatment of MCF-7 cells activates CaM KI, ERK, the transcription factor Elk-1, cyclin D1, and cell growth through CaM KK.	Carbachol	41-50	ETS transcription factor ELK1	Homo sapiens	124-129
19763792-10	2010	Taken together, our results suggest that carbachol treatment of MCF-7 cells activates CaM KI, ERK, the transcription factor Elk-1, cyclin D1, and cell growth through CaM KK.	Carbachol	41-50	cyclin D1	Homo sapiens	131-140
19763792-10	2010	Taken together, our results suggest that carbachol treatment of MCF-7 cells activates CaM KI, ERK, the transcription factor Elk-1, cyclin D1, and cell growth through CaM KK.	Carbachol	41-50	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	166-172
20021253-9	2010	The increased expression and secretion of TGF-beta(2) caused by carbachol were suppressed by atropine (in the range of 10 nM-100 microM) when compared to treatment with carbachol alone (p &lt; 0.001).	Carbachol	169-178	transforming growth factor beta 2	Homo sapiens	42-50
20157258-6	2010	In CPu, the Abeta ability to impair the DA release evoked by the cholinergic agonist carbachol, observed in NAc, was confirmed only in vitro.	Carbachol	85-94	amyloid beta precursor protein	Rattus norvegicus	12-17
19875701-5	2010	Western blot analysis revealed that a prototypical Ca2+-dependent secretagogue, carbachol (CCh; 100 microM), induced phosphorylation of both the 46-kDa and 54-kDa isoforms of JNK.	Carbachol	80-89	mitogen-activated protein kinase 8	Homo sapiens	175-178
19875701-5	2010	Western blot analysis revealed that a prototypical Ca2+-dependent secretagogue, carbachol (CCh; 100 microM), induced phosphorylation of both the 46-kDa and 54-kDa isoforms of JNK.	Carbachol	91-94	mitogen-activated protein kinase 8	Homo sapiens	175-178
19875701-7	2010	CCh-induced JNK phosphorylation was attenuated by the EGFR inhibitor, tyrphostin-AG1478 (1 microM).	Carbachol	0-3	mitogen-activated protein kinase 8	Homo sapiens	12-15
19875701-7	2010	CCh-induced JNK phosphorylation was attenuated by the EGFR inhibitor, tyrphostin-AG1478 (1 microM).	Carbachol	0-3	epidermal growth factor receptor	Homo sapiens	54-58
19875701-8	2010	Pretreatment of voltage-clamped T(84) cells with SP600125 (2 microM), a specific JNK inhibitor, potentiated secretory responses to both CCh and TG but not to FSK.	Carbachol	136-139	mitogen-activated protein kinase 8	Homo sapiens	81-84
19373133-6	2010	The results indicated that PKC-alpha and PKC-epsilon agonists thymelea toxin and carbachol seemed to increase the calcium sensitivity and MLC20 phosphorylation of superior mesenteric artery after hemorrhagic shock and antagonize the increase of MLCP activity in VSMC after hypoxia.	Carbachol	81-90	protein kinase C, alpha	Rattus norvegicus	27-36
19921993-7	2010	An over-activated fetal renin-angiotensin-system (RAS) is associated with changes in vascular pressure following intravenous administration of carbachol, indicating that the cholinergic stimulation-mediated hormonal mechanism in the fetus might play a critical role in the regulation of cardiovascular homeostasis.	Carbachol	143-152	renin	Ovis aries	24-29
19373133-6	2010	The results indicated that PKC-alpha and PKC-epsilon agonists thymelea toxin and carbachol seemed to increase the calcium sensitivity and MLC20 phosphorylation of superior mesenteric artery after hemorrhagic shock and antagonize the increase of MLCP activity in VSMC after hypoxia.	Carbachol	81-90	myosin light chain 12B	Rattus norvegicus	138-143
19779011-5	2009	Accordingly, in isolated colonic crypts pretreated with forskolin and carbachol for 10 min, respectively, and subjected to immunohistochemistry, the NBCe1 signal showed a markedly stronger colocalization with the E-cadherin signal, which was used as a membrane marker, compared with the untreated control.	Carbachol	70-79	cadherin 1	Mus musculus	213-223
20021253-6	2010	RESULTS: Carbachol induced a time-dependent increase in the levels of TGF-beta(2) mRNA and protein in the cytoplasm (p &lt; 0.001).	Carbachol	9-18	transforming growth factor beta 2	Homo sapiens	70-78
20021253-9	2010	The increased expression and secretion of TGF-beta(2) caused by carbachol were suppressed by atropine (in the range of 10 nM-100 microM) when compared to treatment with carbachol alone (p &lt; 0.001).	Carbachol	64-73	transforming growth factor beta 2	Homo sapiens	42-50
19749081-0	2009	Involvement of cyclooxygenase-2 in carbachol-induced positive inotropic response in mouse isolated left atrium.	Carbachol	35-44	prostaglandin-endoperoxide synthase 2	Mus musculus	15-31
19460789-4	2009	The muscarinic receptor agonists carbachol and methacholine both induced modest effects on basal interleukin (IL)-8 and -6 secretion, whereas the secretion of RANTES, eotaxin, vascular endothelial growth factor-A and monocyte chemoattractant protein-1 was not affected.	Carbachol	33-42	vascular endothelial growth factor A	Homo sapiens	176-212
19460789-4	2009	The muscarinic receptor agonists carbachol and methacholine both induced modest effects on basal interleukin (IL)-8 and -6 secretion, whereas the secretion of RANTES, eotaxin, vascular endothelial growth factor-A and monocyte chemoattractant protein-1 was not affected.	Carbachol	33-42	C-C motif chemokine ligand 2	Homo sapiens	217-251
20046026-6	2009	In organ culture, treatment of ileal tissue with 17beta-estradiol greatly suppressed the carbachol-induced increase in phosphorylation at Thr38 in CPI-17 without altering total CPI-17 protein expression.	Carbachol	89-98	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	147-153
19749081-3	2009	In this study, the involvement of cyclooxygenase (COX)-2 in carbachol (CCh)-induced inotropic response was investigated in mouse isolated left atrium.	Carbachol	60-69	cytochrome c oxidase II, mitochondrial	Mus musculus	34-56
19749081-3	2009	In this study, the involvement of cyclooxygenase (COX)-2 in carbachol (CCh)-induced inotropic response was investigated in mouse isolated left atrium.	Carbachol	71-74	cytochrome c oxidase II, mitochondrial	Mus musculus	34-56
19542247-10	2009	In separate experiments, incubation of PCLS with IL-13 or TNFalpha (100 ng/ml) increased airway sensitivity to carbachol.	Carbachol	111-120	interleukin 13	Homo sapiens	49-54
19393327-6	2009	BNP induced a weak relaxant activity on carbachol-contracted bronchi in nonsensitized (relaxation: 4.23+/-0.51%) and passively sensitized bronchi (relaxation: 11.31+/-2.22%).	Carbachol	40-49	natriuretic peptide B	Homo sapiens	0-3
19673741-4	2009	The cholinergic agonist carbachol has been shown to induce axonal outgrowth through intracellular calcium mobilization, protein kinase C (PKC) activation, and ERK1/2 phosphorylation.	Carbachol	24-33	protein kinase C, gamma	Rattus norvegicus	120-136
19673741-4	2009	The cholinergic agonist carbachol has been shown to induce axonal outgrowth through intracellular calcium mobilization, protein kinase C (PKC) activation, and ERK1/2 phosphorylation.	Carbachol	24-33	protein kinase C, gamma	Rattus norvegicus	138-141
19673741-4	2009	The cholinergic agonist carbachol has been shown to induce axonal outgrowth through intracellular calcium mobilization, protein kinase C (PKC) activation, and ERK1/2 phosphorylation.	Carbachol	24-33	mitogen activated protein kinase 3	Rattus norvegicus	159-165
19673741-13	2009	CONCLUSIONS: Ethanol inhibited carbachol-induced neurite outgrowth by inhibiting PKC and ERK1/2 activation.	Carbachol	31-40	protein kinase C, gamma	Rattus norvegicus	81-84
19673741-13	2009	CONCLUSIONS: Ethanol inhibited carbachol-induced neurite outgrowth by inhibiting PKC and ERK1/2 activation.	Carbachol	31-40	mitogen activated protein kinase 3	Rattus norvegicus	89-95
19801823-5	2009	Carbacol and nerve growth factor (NGF), which are ERK1/2 activators, protected the neurons after CPF withdrawal, while atropine and PD98059, which are ERK1/2 inhibitors, exacerbated the cytotoxicity, indicating the involvement of inhibition of ERK1/2 phosphorylation in CPF-induced delayed cytotoxicity.	Carbachol	0-8	mitogen activated protein kinase 3	Rattus norvegicus	50-56
19615971-0	2009	Carbachol induces p70S6K1 activation through an ERK-dependent but Akt-independent pathway in human colonic epithelial cells.	Carbachol	0-9	EPH receptor B2	Homo sapiens	48-51
19615971-0	2009	Carbachol induces p70S6K1 activation through an ERK-dependent but Akt-independent pathway in human colonic epithelial cells.	Carbachol	0-9	AKT serine/threonine kinase 1	Homo sapiens	66-69
19615971-1	2009	Stimulation of human colonic epithelial T84 cells with the muscarinic receptor agonist carbachol, a stable analog of acetylcholine, induced Akt, p70S6K1 and ERK activation.	Carbachol	87-96	AKT serine/threonine kinase 1	Homo sapiens	140-143
19615971-1	2009	Stimulation of human colonic epithelial T84 cells with the muscarinic receptor agonist carbachol, a stable analog of acetylcholine, induced Akt, p70S6K1 and ERK activation.	Carbachol	87-96	EPH receptor B2	Homo sapiens	157-160
19615971-2	2009	Treatment of T84 cells with the selective inhibitor of EGF receptor (EGFR) tyrosine kinase AG1478 abrogated Akt phosphorylation on Ser(473) induced by either carbachol or EGF, indicating that carbachol-induced Akt activation is mediated through EGFR transactivation.	Carbachol	158-167	epidermal growth factor receptor	Homo sapiens	55-67
19615971-2	2009	Treatment of T84 cells with the selective inhibitor of EGF receptor (EGFR) tyrosine kinase AG1478 abrogated Akt phosphorylation on Ser(473) induced by either carbachol or EGF, indicating that carbachol-induced Akt activation is mediated through EGFR transactivation.	Carbachol	158-167	epidermal growth factor receptor	Homo sapiens	69-73
19615971-2	2009	Treatment of T84 cells with the selective inhibitor of EGF receptor (EGFR) tyrosine kinase AG1478 abrogated Akt phosphorylation on Ser(473) induced by either carbachol or EGF, indicating that carbachol-induced Akt activation is mediated through EGFR transactivation.	Carbachol	158-167	AKT serine/threonine kinase 1	Homo sapiens	108-111
19615971-2	2009	Treatment of T84 cells with the selective inhibitor of EGF receptor (EGFR) tyrosine kinase AG1478 abrogated Akt phosphorylation on Ser(473) induced by either carbachol or EGF, indicating that carbachol-induced Akt activation is mediated through EGFR transactivation.	Carbachol	192-201	epidermal growth factor receptor	Homo sapiens	55-67
19615971-2	2009	Treatment of T84 cells with the selective inhibitor of EGF receptor (EGFR) tyrosine kinase AG1478 abrogated Akt phosphorylation on Ser(473) induced by either carbachol or EGF, indicating that carbachol-induced Akt activation is mediated through EGFR transactivation.	Carbachol	192-201	epidermal growth factor receptor	Homo sapiens	69-73
19615971-2	2009	Treatment of T84 cells with the selective inhibitor of EGF receptor (EGFR) tyrosine kinase AG1478 abrogated Akt phosphorylation on Ser(473) induced by either carbachol or EGF, indicating that carbachol-induced Akt activation is mediated through EGFR transactivation.	Carbachol	192-201	AKT serine/threonine kinase 1	Homo sapiens	108-111
19659456-1	2009	We tested the hypothesis that the de-endothelialized artery rings from the left anterior descending (LAD) coronary artery and its left ventricular branch (LVB) differ in their contractile responses to Na(+)-Ca(2+)-exchanger (NCX) mediated Ca(2+)-entry, muscarinic receptor activation with carbachol, and sarco/endoplasmic reticulum Ca(2+) pump (SERCA) inhibition with thapsigargin.	Carbachol	289-298	solute carrier family 8 member A1	Homo sapiens	201-223
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	ER lipid raft associated 1	Homo sapiens	15-20
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	ER lipid raft associated 2	Homo sapiens	25-30
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	99-113
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	ER lipid raft associated 1	Homo sapiens	256-263
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	291-305
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	291-305
19751772-5	2009	Suppression of SPFH1 and SPFH2 expression by RNA interference markedly inhibited carbachol-induced IP(3) receptor polyubiquitination and degradation, but did not affect carbachol-induced calcium mobilization or IkappaBalpha processing, indicating that the SPFH1/2 complex is a key player in IP(3) receptor ERAD, acting at a step after IP(3) receptor activation, but prior to IP(3) receptor polyubiquitination.	Carbachol	81-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	291-305
19626679-1	2009	Regulations of intracellular protein kinase C (PKC) on carbachol (CCh)-induced intracellular calcium ([Ca(2+)]i) responses were investigated in different stages of melanoma cells.	Carbachol	55-64	protein kinase C alpha	Homo sapiens	47-50
19626679-3	2009	Pretreatment of phorbol 12, 13-dibutyrate (PDBu, 2 microM), an activator of intracellular PKC, significantly suppressed CCh-induced peak reactions in WM793B, SK-MEL-5, and A2058 cells.	Carbachol	120-123	protein kinase C alpha	Homo sapiens	90-93
19626679-5	2009	Short interfering RNA (siRNA) targeting to PKCalpha in WM793B cells enhanced CCh-induced peak calcium reactions.	Carbachol	77-80	protein kinase C alpha	Homo sapiens	43-51
19626679-7	2009	Moreover, intracellular PKCalpha activated by exogenous agonist and expressed through endogenous gene transcription negatively regulated CCh-induced calcium responses.	Carbachol	137-140	protein kinase C alpha	Homo sapiens	24-32
19626679-8	2009	The functional analysis on the relationship between CCh-induced calcium response and endogenous PKCalpha expression might be helpful to predict the development of melanoma.	Carbachol	52-55	protein kinase C alpha	Homo sapiens	96-104
19680632-6	2009	In contrast, in HEK(hUT) cells, primary stimulation with carbachol (250 microM) reduced a secondary challenge to U-II (1 microM) by 84% and primary challenge with U-II reduced a secondary challenge to carbachol by 76%.	Carbachol	57-66	urotensin 2	Homo sapiens	113-117
19680632-6	2009	In contrast, in HEK(hUT) cells, primary stimulation with carbachol (250 microM) reduced a secondary challenge to U-II (1 microM) by 84% and primary challenge with U-II reduced a secondary challenge to carbachol by 76%.	Carbachol	201-210	urotensin 2	Homo sapiens	163-167
19628652-8	2009	In Western blot analysis, 8-Br-cGMP reduced the signal for phosphorylated MYPT-1 in carbachol-stimulated jejunum but not in colon.	Carbachol	84-93	protein phosphatase 1, regulatory subunit 12A	Mus musculus	74-80
19549525-6	2009	In TRPC4-deficient ileal myocytes the carbachol-induced membrane depolarizations are diminished greatly and the atropine-sensitive contraction elicited by acetylcholine release from excitatory motor neurons is reduced greatly.	Carbachol	38-47	transient receptor potential cation channel, subfamily C, member 4	Mus musculus	3-8
20149029-5	2009	RESULTS: All curves were displaced to the right by hCG in a concentration-dependent manner with significant inhibition of contractions induced by carbachol (P &lt; 0.001) and KCl (P = 0.016) but not those induced by alpha,beta-methylene ATP (P = 0.4).	Carbachol	146-155	chorionic gonadotropin subunit beta 5	Homo sapiens	51-54
20149029-8	2009	CONCLUSIONS: hCG significantly inhibited in vitro detrusor contractions induced by depolarization (KCl) and cholinergic (carbachol) but not purinergic (alpha,beta-methylene ATP) stimulation in a dose-dependent manner in female rats.	Carbachol	121-130	chorionic gonadotropin subunit beta 5	Homo sapiens	13-16
19615971-4	2009	In contrast, treatment with the selective MEK inhibitor U0126 (but not with the inactive analog U0124) inhibited carbachol-induced p70S6K1 activation, indicating that the MEK/ERK/RSK pathway plays a critical role in p70S6K1 activation in GPCR-stimulated T84 cells.	Carbachol	113-122	mitogen-activated protein kinase kinase 7	Homo sapiens	42-45
19615971-4	2009	In contrast, treatment with the selective MEK inhibitor U0126 (but not with the inactive analog U0124) inhibited carbachol-induced p70S6K1 activation, indicating that the MEK/ERK/RSK pathway plays a critical role in p70S6K1 activation in GPCR-stimulated T84 cells.	Carbachol	113-122	mitogen-activated protein kinase kinase 7	Homo sapiens	171-174
19615971-4	2009	In contrast, treatment with the selective MEK inhibitor U0126 (but not with the inactive analog U0124) inhibited carbachol-induced p70S6K1 activation, indicating that the MEK/ERK/RSK pathway plays a critical role in p70S6K1 activation in GPCR-stimulated T84 cells.	Carbachol	113-122	EPH receptor B2	Homo sapiens	175-178
19615971-4	2009	In contrast, treatment with the selective MEK inhibitor U0126 (but not with the inactive analog U0124) inhibited carbachol-induced p70S6K1 activation, indicating that the MEK/ERK/RSK pathway plays a critical role in p70S6K1 activation in GPCR-stimulated T84 cells.	Carbachol	113-122	ribosomal protein S6 kinase A2	Homo sapiens	179-182
19542247-10	2009	In separate experiments, incubation of PCLS with IL-13 or TNFalpha (100 ng/ml) increased airway sensitivity to carbachol.	Carbachol	111-120	tumor necrosis factor	Homo sapiens	58-66
19535329-6	2009	Similarly, in Caco-2BBe cells, NHERF3 and NHE3 colocalized in the BB under basal conditions but after elevation of [Ca(2+)](i) by carbachol, this overlap was abolished.	Carbachol	130-139	PDZ domain containing 1	Homo sapiens	31-37
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Carbachol	251-260	peptide YY	Cavia porcellus	12-15
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Carbachol	251-260	pro-neuropeptide Y	Cavia porcellus	19-33
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Carbachol	251-260	pro-neuropeptide Y	Cavia porcellus	35-38
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Carbachol	262-265	peptide YY	Cavia porcellus	12-15
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Carbachol	262-265	pro-neuropeptide Y	Cavia porcellus	19-33
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Carbachol	262-265	pro-neuropeptide Y	Cavia porcellus	35-38
19535329-8	2009	Also, carbachol-mediated inhibition of NHE3 activity was abolished in Caco-2BBe cells in which NHERF3 protein expression was significantly reduced.	Carbachol	6-15	solute carrier family 9 member A3	Homo sapiens	39-43
19535329-8	2009	Also, carbachol-mediated inhibition of NHE3 activity was abolished in Caco-2BBe cells in which NHERF3 protein expression was significantly reduced.	Carbachol	6-15	PDZ domain containing 1	Homo sapiens	95-101
19656467-5	2009	Carbachol (CCH; 300 microM) was able to evoke glutamate release more efficiently from PC12-NCS-1 (15.3+/-1.0nmol/mg of protein) than wild type cells (PC12-wt; 8.3+/-0.9nmol/mg of protein).	Carbachol	0-9	neuronal calcium sensor 1	Rattus norvegicus	86-96
19656467-5	2009	Carbachol (CCH; 300 microM) was able to evoke glutamate release more efficiently from PC12-NCS-1 (15.3+/-1.0nmol/mg of protein) than wild type cells (PC12-wt; 8.3+/-0.9nmol/mg of protein).	Carbachol	11-14	neuronal calcium sensor 1	Rattus norvegicus	86-96
19656467-8	2009	and [Ca2+]i (766.4+/-40.0 and 687.8+/-37.1nmol/L) was observed after CCH stimulus of PC12-NCS-1 compared with PC12-wt.	Carbachol	69-72	neuronal calcium sensor 1	Rattus norvegicus	85-95
19656467-13	2009	Together, our data show that overexpression of NCS-1 in PC12 cells induces an enhancement of intracellular second messenger and transmitter release dependent on CCH response, suggesting that muscarinic signaling is "up-regulated" in this cell model.	Carbachol	161-164	neuronal calcium sensor 1	Rattus norvegicus	47-52
19457892-4	2009	Confocal fluorescence microscopy indicated that cp-Galpha(i)1/2 and/or cp-Galpha(i)3 peptides moderated carbachol attenuation of cellular Ca(2+) transients in isolated atrial myocytes.	Carbachol	104-113	protein phosphatase 1 regulatory inhibitor subunit 1A	Canis lupus familiaris	48-63
19535329-6	2009	Similarly, in Caco-2BBe cells, NHERF3 and NHE3 colocalized in the BB under basal conditions but after elevation of [Ca(2+)](i) by carbachol, this overlap was abolished.	Carbachol	130-139	solute carrier family 9 member A3	Homo sapiens	42-46
19005736-6	2009	The increase in IP accumulation induced by CCh after TNF-alpha immersion was reduced in the BSMCs by LLLT.	Carbachol	43-46	tumor necrosis factor	Rattus norvegicus	53-62
19558456-2	2009	In hippocampal primary and cerebellar granule neuron cultures expressing endogenous M1 receptor, carbachol increased the levels of a prototypical phase II antioxidant enzyme, heme oxygenase-1.	Carbachol	97-106	heme oxygenase 1	Rattus norvegicus	175-191
19352616-10	2009	CONCLUSION: Despite the fact that inhibitors of PDE1, PDE4, and PDE5 exerted only a weak relaxant response on detrusor strips precontracted by carbachol, our findings indicate that both the cAMP and cGMP pathways might be involved in the relaxation mechanism of human detrusor smooth muscle.	Carbachol	143-152	phosphodiesterase 4A	Homo sapiens	54-58
19578554-11	2009	Carbachol also activated p42/44 mitogen-activated protein kinase (MAPK) and Ras in a time-dependent manner.	Carbachol	0-9	mitogen-activated protein kinase 1	Mus musculus	66-70
19352616-10	2009	CONCLUSION: Despite the fact that inhibitors of PDE1, PDE4, and PDE5 exerted only a weak relaxant response on detrusor strips precontracted by carbachol, our findings indicate that both the cAMP and cGMP pathways might be involved in the relaxation mechanism of human detrusor smooth muscle.	Carbachol	143-152	phosphodiesterase 5A	Homo sapiens	64-68
19190235-7	2009	In addition, down-regulation of ERK1/2 with small interfering RNA abolished the neuritogenic effect of carbachol.	Carbachol	103-112	mitogen activated protein kinase 3	Rattus norvegicus	32-38
19356605-6	2009	In another set of experiments, the specific NK1 receptor antagonist L-703,606 (5 microg) was microinjected in the PAG following LH stimulation with carbachol abolished LH-induced antinociception as well.	Carbachol	148-157	tachykinin receptor 1	Rattus norvegicus	44-56
19200344-2	2009	By activating M(3) muscarinic receptors, the cholinergic agonist carbachol inhibits DomA-induced apoptosis, and the anti-apoptotic action of carbachol is more pronounced in CGNs from Gclm (+/+) mice.	Carbachol	141-150	glutamate-cysteine ligase, modifier subunit	Mus musculus	183-187
19443836-4	2009	In HEK293 cells expressing TRPC6, application of mechanical stimuli (hypotonicity, shear, 2,4,6-trinitrophenol) caused, albeit not effective by themselves, a prominent potentiation of cationic currents (I(TRPC6)) induced by a muscarinic receptor agonist carbachol.	Carbachol	254-263	transient receptor potential cation channel subfamily C member 6	Homo sapiens	27-32
19443836-7	2009	Single TRPC6 channel activity evoked by carbachol was also enhanced by a negative pressure added in the patch pipette.	Carbachol	40-49	transient receptor potential cation channel subfamily C member 6	Homo sapiens	7-12
19443836-8	2009	Mechanical potentiation of carbachol- or OAG-induced I(TRPC6) was abolished by small interfering RNA knockdown of cytosolic phospholipase A(2) or pharmacological inhibition of omega-hydroxylation of arachidonic acid into 20-HETE (20-hydroxyeicosatetraenoic acid).	Carbachol	27-36	transient receptor potential cation channel subfamily C member 6	Homo sapiens	55-60
19450258-9	2009	Decreased sensitivity to carbachol was associated with increased expression of IL-4 and IL-6 mRNA in jejunum.	Carbachol	25-34	interleukin 4	Mus musculus	79-83
19450258-9	2009	Decreased sensitivity to carbachol was associated with increased expression of IL-4 and IL-6 mRNA in jejunum.	Carbachol	25-34	interleukin 6	Mus musculus	88-92
19332491-5	2009	Specifically, Ca(2+) entry seen after carbachol treatment in cells transiently expressing TRPC1, TRPC3, TRPC5 or TRPC6 was not enhanced by the co-expression of STIM1.	Carbachol	38-47	transient receptor potential cation channel subfamily C member 1	Homo sapiens	90-95
19332491-5	2009	Specifically, Ca(2+) entry seen after carbachol treatment in cells transiently expressing TRPC1, TRPC3, TRPC5 or TRPC6 was not enhanced by the co-expression of STIM1.	Carbachol	38-47	transient receptor potential cation channel subfamily C member 3	Homo sapiens	97-102
19332491-5	2009	Specifically, Ca(2+) entry seen after carbachol treatment in cells transiently expressing TRPC1, TRPC3, TRPC5 or TRPC6 was not enhanced by the co-expression of STIM1.	Carbachol	38-47	transient receptor potential cation channel subfamily C member 5	Homo sapiens	104-109
19332491-5	2009	Specifically, Ca(2+) entry seen after carbachol treatment in cells transiently expressing TRPC1, TRPC3, TRPC5 or TRPC6 was not enhanced by the co-expression of STIM1.	Carbachol	38-47	transient receptor potential cation channel subfamily C member 6	Homo sapiens	113-118
19190235-8	2009	These data suggest an involvement of Ca(2+), PKC, and ERK1/2 in carbachol-induced axonal growth.	Carbachol	64-73	protein kinase C, gamma	Rattus norvegicus	45-48
19190235-8	2009	These data suggest an involvement of Ca(2+), PKC, and ERK1/2 in carbachol-induced axonal growth.	Carbachol	64-73	mitogen activated protein kinase 3	Rattus norvegicus	54-60
19190235-9	2009	Carbachol indeed increased the release of Ca(2+) from intracellular stores and induced PKC and ERK1/2 activation.	Carbachol	0-9	protein kinase C, gamma	Rattus norvegicus	87-90
19190235-9	2009	Carbachol indeed increased the release of Ca(2+) from intracellular stores and induced PKC and ERK1/2 activation.	Carbachol	0-9	mitogen activated protein kinase 3	Rattus norvegicus	95-101
19190235-10	2009	Additional experiments showed that PKC, but not Ca(2+), is involved in carbachol-induced ERK1/2 activation.	Carbachol	71-80	protein kinase C, gamma	Rattus norvegicus	35-38
19190235-10	2009	Additional experiments showed that PKC, but not Ca(2+), is involved in carbachol-induced ERK1/2 activation.	Carbachol	71-80	mitogen activated protein kinase 3	Rattus norvegicus	89-95
19190174-8	2009	The contributions of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) to CCh-induced contractions were significantly increased during colitis.	Carbachol	116-119	mitogen-activated protein kinase 1	Mus musculus	21-58
19190174-8	2009	The contributions of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) to CCh-induced contractions were significantly increased during colitis.	Carbachol	116-119	mitogen-activated protein kinase 1	Mus musculus	60-63
19190174-8	2009	The contributions of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) to CCh-induced contractions were significantly increased during colitis.	Carbachol	116-119	mitogen-activated protein kinase 1	Homo sapiens	107-111
19269274-3	2009	Consequently, we performed a quantitative, regionally-specific analysis of the Fos immunoreactivity of neurons in the POA of the cat during NREM sleep and REM sleep induced by microinjections of carbachol into the nucleus pontis oralis (REMc), as well as during quiet and alert wakefulness.	Carbachol	195-204	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-82
19166928-8	2009	However, GI-hormones/neurotransmitters [CCK, bombesin, carbachol] activating phospholipase C (PLC) inhibited basal and growth-factor-stimulated Akt activation.	Carbachol	55-64	AKT serine/threonine kinase 1	Homo sapiens	144-147
19200344-5	2009	Carbachol activates extracellular signal-regulated kinases 1/2 (ERK1/2) MAPK and phospahtidylinositol-3 kinase (PI3K) in CGNs from both genotypes.	Carbachol	0-9	mitogen-activated protein kinase 3	Mus musculus	20-62
19200344-5	2009	Carbachol activates extracellular signal-regulated kinases 1/2 (ERK1/2) MAPK and phospahtidylinositol-3 kinase (PI3K) in CGNs from both genotypes.	Carbachol	0-9	mitogen-activated protein kinase 3	Mus musculus	64-70
19200344-6	2009	However, while the protective effect of carbachol is mediated by ERK1/2 MAPK in CGNs from both mouse genotypes, inhibitors of PI3K are only effective at antagonizing the action of carbachol in CGNs from Gclm (+/+) mice.	Carbachol	40-49	mitogen-activated protein kinase 3	Mus musculus	65-71
19200344-7	2009	In CGNs from both Gclm (+/+) and (-/-) mice, carbachol induces a MAPK-dependent increase in the level of the anti-apoptotic protein Bcl-2.	Carbachol	45-54	glutamate-cysteine ligase, modifier subunit	Mus musculus	18-22
19200344-7	2009	In CGNs from both Gclm (+/+) and (-/-) mice, carbachol induces a MAPK-dependent increase in the level of the anti-apoptotic protein Bcl-2.	Carbachol	45-54	B cell leukemia/lymphoma 2	Mus musculus	132-137
19200344-8	2009	In contrast, carbachol causes a PI3K-dependent increase in GCL activity and of GSH levels only in CGNs from Gclm (+/+) mice.	Carbachol	13-22	glutamate-cysteine ligase, modifier subunit	Mus musculus	108-112
19200344-4	2009	Carbachol inhibits DomA-induced activation of Jun N-terminal (JNK) and p38 kinases, increased translocation to mitochondria of the pro-apoptotic protein Bax, and activation of caspase-3.	Carbachol	0-9	mitogen-activated protein kinase 8	Mus musculus	62-65
19200344-4	2009	Carbachol inhibits DomA-induced activation of Jun N-terminal (JNK) and p38 kinases, increased translocation to mitochondria of the pro-apoptotic protein Bax, and activation of caspase-3.	Carbachol	0-9	mitogen-activated protein kinase 14	Mus musculus	71-74
19200344-4	2009	Carbachol inhibits DomA-induced activation of Jun N-terminal (JNK) and p38 kinases, increased translocation to mitochondria of the pro-apoptotic protein Bax, and activation of caspase-3.	Carbachol	0-9	BCL2-associated X protein	Mus musculus	153-156
19200344-4	2009	Carbachol inhibits DomA-induced activation of Jun N-terminal (JNK) and p38 kinases, increased translocation to mitochondria of the pro-apoptotic protein Bax, and activation of caspase-3.	Carbachol	0-9	caspase 3	Mus musculus	176-185
19109404-9	2009	GLP-2 induced concentration-dependent relaxation in carbachol-precontracted fundic strips but not in antral strips.	Carbachol	52-61	glucagon-like peptide 2 receptor	Mus musculus	0-5
19052105-3	2009	DSM strips from SM-B KO mice generated more force in response to electrical field stimulation, KCl, carbachol, and phorbol 12,13-dibutyrate than that of age-matched wild-type mice.	Carbachol	100-109	small nuclear ribonucleoprotein B	Mus musculus	16-20
19052105-7	2009	Two-dimensional gel electrophoresis revealed an increased level of MLC20 phosphorylation in response to carbachol.	Carbachol	104-113	myosin, light chain 12B, regulatory	Mus musculus	67-72
19109944-11	2009	A phospholipase C (PLC) inhibitor U73122, a protein kinase C (PKC) inhibitor chelerythrine and a phospholipase A(2) (PLA(2)) inhibitor AACOCF(3) inhibited the [Ca(2+)](i) response to carbamylcholine or oxotremorine M, while these inhibitors did not block the effect of nicotine.	Carbachol	183-198	phospholipase A2, group IB, pancreas	Mus musculus	117-123
19056381-0	2009	Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol.	Carbachol	121-130	interleukin-10	Oryctolagus cuniculus	17-22
19141314-5	2009	The cholinergic agonist carbachol also depressed GluR1-3 mRNA levels, suggesting that AMPAR down-regulation is a global response to extended periods of elevated neuronal activity.	Carbachol	24-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
19070673-3	2009	Carbachol (CCh) dose-dependently stimulated both mTOR and p70S6K phosphorylations and these responses were abolished by pertussis toxin pretreatment, indicating the involvement of the G(i)-coupled M(4) mAChR.	Carbachol	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	49-53
19159405-9	2009	Carbachol-evoked inotropic responses and increase in phosphorylated MLC-2 were attenuated by MLC kinase (ML-9) and Rho-kinase inhibition (Y-27632), and inotropic responses were abolished by Pertussis toxin pretreatment.	Carbachol	0-9	myosin light chain 2	Rattus norvegicus	68-73
18984743-10	2009	No difference in the switch-off rate of glucose-stimulated insulin secretion was observed between genotypes, but the cholinergic agonist carbamylcholine enhanced glucose-induced insulin secretion to a lesser extent in Sst(-/-) islets compared with controls.	Carbachol	137-152	somatostatin	Mus musculus	218-221
19166483-8	2009	However, when these stores were depleted by block of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump or calcium release was activated by carbachol, the absence of Cav-1 or caveolae had little or no effect.	Carbachol	148-157	ATPase, Ca++ transporting, ubiquitous	Mus musculus	57-98
19166483-8	2009	However, when these stores were depleted by block of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump or calcium release was activated by carbachol, the absence of Cav-1 or caveolae had little or no effect.	Carbachol	148-157	ATPase, Ca++ transporting, ubiquitous	Mus musculus	100-105
19070673-3	2009	Carbachol (CCh) dose-dependently stimulated both mTOR and p70S6K phosphorylations and these responses were abolished by pertussis toxin pretreatment, indicating the involvement of the G(i)-coupled M(4) mAChR.	Carbachol	0-9	ribosomal protein S6 kinase B1	Rattus norvegicus	58-64
19070673-3	2009	Carbachol (CCh) dose-dependently stimulated both mTOR and p70S6K phosphorylations and these responses were abolished by pertussis toxin pretreatment, indicating the involvement of the G(i)-coupled M(4) mAChR.	Carbachol	11-14	mechanistic target of rapamycin kinase	Rattus norvegicus	49-53
19070673-3	2009	Carbachol (CCh) dose-dependently stimulated both mTOR and p70S6K phosphorylations and these responses were abolished by pertussis toxin pretreatment, indicating the involvement of the G(i)-coupled M(4) mAChR.	Carbachol	11-14	ribosomal protein S6 kinase B1	Rattus norvegicus	58-64
19070673-6	2009	Although inhibition of protein phosphatase 2A by okadaic acid augmented the transient effects of CCh on Akt/tuberin phosphorylations, it failed to significantly prolong these responses.	Carbachol	97-100	AKT serine/threonine kinase 1	Rattus norvegicus	104-107
19070673-6	2009	Although inhibition of protein phosphatase 2A by okadaic acid augmented the transient effects of CCh on Akt/tuberin phosphorylations, it failed to significantly prolong these responses.	Carbachol	97-100	TSC complex subunit 2	Rattus norvegicus	108-115
19070673-7	2009	The total protein level of PTEN (tumor suppressor gene phosphatase and tensin homologue deleted on chromosome ten) was attenuated upon NGF, but not CCh treatment.	Carbachol	148-151	phosphatase and tensin homolog	Rattus norvegicus	27-31
19340558-8	2009	In addition, sensitivity to carbachol was impaired in mice without CCK-2R.	Carbachol	28-37	cholecystokinin B receptor	Mus musculus	67-73
18651719-2	2009	Although Abeta itself did not increase Ca(2+), it exacerbated the effects of carbachol.	Carbachol	77-86	amyloid beta precursor protein	Homo sapiens	9-14
19340558-10	2009	In conclusion, CCK-2R is necessary to respond to carbachol as well as to produce the maximal acid secretion, while the role of CCK-1R in acid secretion is less important.	Carbachol	49-58	cholecystokinin B receptor	Mus musculus	15-21
19093744-9	2009	In conclusion, ET(B) receptor stimulation relaxes the carbachol precontracted iris sphincter muscle, an effect that is mediated by the ET(B2) receptor subtype, through NO and the release of prostaglandins.	Carbachol	54-63	endothelin receptor type B	Oryctolagus cuniculus	15-19
18830899-15	2009	CONCLUSIONS: Based on these findings it is concluded that curcumin prevented the reduction in carbachol-induced contraction in trinitrobenzenesulphonic acid -treated rats by modulating NF-kB signaling pathway.	Carbachol	94-103	nuclear factor kappa B subunit 1	Rattus norvegicus	185-190
18929546-4	2008	This paper examined the effects of acute PKC inhibition on firing responses to carbachol, NMDA or AMPA using patch clamp recordings from brain slices.	Carbachol	79-88	proline rich transmembrane protein 2	Homo sapiens	41-44
19267388-9	2009	Pharmacological studies revealed a modest, gender-specific reduction in sensitivity of isolated detrusor strips from UPII KO female mice to carbachol-induced contractions.	Carbachol	140-149	uroplakin 2	Mus musculus	117-121
19011095-6	2008	However, muscle strips from SM2(-/-) bladder showed increased contraction to K(+) depolarization or in response to M3 receptor agonist Carbachol.	Carbachol	135-144	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	28-31
20201386-4	2009	Menthol (0.1-1 mmol/l) per se virtually unaffected the basal tone, but inhibited in a dose-dependent manner KCl-, CCh- and Nor-evoked contractions of both parts of the vas deference by 30-50%.	Carbachol	114-117	arginine vasopressin	Rattus norvegicus	168-171
18854172-7	2008	Coexpression with muscarinic receptor M2 induced TRPC4 current activation by muscarinic stimulation with carbachol, which was inhibited by pertussis toxin.	Carbachol	105-114	transient receptor potential cation channel subfamily C member 4	Homo sapiens	49-54
18989912-3	2008	The high nAChR activity of carbamoylcholine analogue 5d was found to reside in its R-enantiomer, a characteristic most likely true for all other compounds in the series.	Carbachol	27-43	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	9-14
19006330-0	2008	Analysis of the reaction of carbachol with acetylcholinesterase using thioflavin T as a coupled fluorescence reporter.	Carbachol	28-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-63
19006330-5	2008	Here, we focus on the reaction of carbachol (carbamoylcholine) with AChE.	Carbachol	34-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
19006330-5	2008	Here, we focus on the reaction of carbachol (carbamoylcholine) with AChE.	Carbachol	45-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
18832081-11	2008	Maximal cardioinhibitory response to the M(2)-receptor agonist carbachol (0.5 mg/kg) compared with basal heart rate was attenuated in Galphai2(-/-) mice (0.08 +/- 0.04; n = 6) compared to control (0.27 +/- 0.04; n = 7 P &lt; 0.05).	Carbachol	63-72	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	134-142
18832449-9	2008	Carbachol-stimulated phosphorylation of S(136) was inhibited by the CAMK2 inhibitor KN93 (IC(50) 38 microM) and by the calmodulin antagonist W7 (IC(50) 3.3 nM).	Carbachol	0-9	calcium/calmodulin dependent protein kinase II beta	Homo sapiens	68-73
18832449-9	2008	Carbachol-stimulated phosphorylation of S(136) was inhibited by the CAMK2 inhibitor KN93 (IC(50) 38 microM) and by the calmodulin antagonist W7 (IC(50) 3.3 nM).	Carbachol	0-9	calmodulin 1	Homo sapiens	119-129
18845574-4	2008	Here, we demonstrate that protein kinase D1 (PKD1) is a key downstream target of PKCdelta and PKCepsilon in pancreatic acinar cells stimulated by two major secretagogues, CCK-8 and the cholinergic agonist carbachol (CCh), and that PKD1 is necessary for NF-kappaB activation induced by CCK-8 and CCh.	Carbachol	205-214	protein kinase D1	Rattus norvegicus	26-43
18845574-4	2008	Here, we demonstrate that protein kinase D1 (PKD1) is a key downstream target of PKCdelta and PKCepsilon in pancreatic acinar cells stimulated by two major secretagogues, CCK-8 and the cholinergic agonist carbachol (CCh), and that PKD1 is necessary for NF-kappaB activation induced by CCK-8 and CCh.	Carbachol	205-214	protein kinase D1	Rattus norvegicus	45-49
18845574-4	2008	Here, we demonstrate that protein kinase D1 (PKD1) is a key downstream target of PKCdelta and PKCepsilon in pancreatic acinar cells stimulated by two major secretagogues, CCK-8 and the cholinergic agonist carbachol (CCh), and that PKD1 is necessary for NF-kappaB activation induced by CCK-8 and CCh.	Carbachol	216-219	protein kinase D1	Rattus norvegicus	26-43
18845574-4	2008	Here, we demonstrate that protein kinase D1 (PKD1) is a key downstream target of PKCdelta and PKCepsilon in pancreatic acinar cells stimulated by two major secretagogues, CCK-8 and the cholinergic agonist carbachol (CCh), and that PKD1 is necessary for NF-kappaB activation induced by CCK-8 and CCh.	Carbachol	216-219	protein kinase D1	Rattus norvegicus	45-49
18845574-4	2008	Here, we demonstrate that protein kinase D1 (PKD1) is a key downstream target of PKCdelta and PKCepsilon in pancreatic acinar cells stimulated by two major secretagogues, CCK-8 and the cholinergic agonist carbachol (CCh), and that PKD1 is necessary for NF-kappaB activation induced by CCK-8 and CCh.	Carbachol	295-298	protein kinase D1	Rattus norvegicus	26-43
18845574-4	2008	Here, we demonstrate that protein kinase D1 (PKD1) is a key downstream target of PKCdelta and PKCepsilon in pancreatic acinar cells stimulated by two major secretagogues, CCK-8 and the cholinergic agonist carbachol (CCh), and that PKD1 is necessary for NF-kappaB activation induced by CCK-8 and CCh.	Carbachol	295-298	protein kinase D1	Rattus norvegicus	45-49
18845574-5	2008	Both CCK-8 and CCh dose dependently induced a rapid and striking activation of PKD1 in rat pancreatic acinar cells, as measured by in vitro kinase assay and by phosphorylation at PKD1 activation loop (Ser744/748) or autophosphorylation site (Ser916).	Carbachol	15-18	protein kinase D1	Rattus norvegicus	79-83
18845574-5	2008	Both CCK-8 and CCh dose dependently induced a rapid and striking activation of PKD1 in rat pancreatic acinar cells, as measured by in vitro kinase assay and by phosphorylation at PKD1 activation loop (Ser744/748) or autophosphorylation site (Ser916).	Carbachol	15-18	protein kinase D1	Rattus norvegicus	179-183
18845574-6	2008	The phosphorylation and activation of PKD1 correlated with NF-kappaB activity stimulated by CCK-8 or CCh, as measured by NF-kappaB DNA binding.	Carbachol	101-104	protein kinase D1	Rattus norvegicus	38-42
18845574-6	2008	The phosphorylation and activation of PKD1 correlated with NF-kappaB activity stimulated by CCK-8 or CCh, as measured by NF-kappaB DNA binding.	Carbachol	101-104	nuclear factor kappa B subunit 1	Homo sapiens	59-68
18845574-6	2008	The phosphorylation and activation of PKD1 correlated with NF-kappaB activity stimulated by CCK-8 or CCh, as measured by NF-kappaB DNA binding.	Carbachol	101-104	nuclear factor kappa B subunit 1	Homo sapiens	121-130
18845574-8	2008	Conversely, overexpression of PKD1 resulted in augmentation of CCK-8- and CCh-stimulated NF-kappaB activation.	Carbachol	74-77	protein kinase D1	Rattus norvegicus	30-34
18845574-8	2008	Conversely, overexpression of PKD1 resulted in augmentation of CCK-8- and CCh-stimulated NF-kappaB activation.	Carbachol	74-77	nuclear factor kappa B subunit 1	Homo sapiens	89-98
19017493-3	2008	Treatment of the four cell lines with the cholinergic agonist carbachol led to the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2).	Carbachol	62-71	mitogen-activated protein kinase 1	Homo sapiens	97-143
19017493-3	2008	Treatment of the four cell lines with the cholinergic agonist carbachol led to the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2).	Carbachol	62-71	mitogen-activated protein kinase 3	Homo sapiens	145-151
19017493-4	2008	In SNU-407 cells, carbachol significantly stimulated cell proliferation, which could be abolished by the muscarinic antagonist atropine and the ERK1/2 kinase inhibitor PD98059.	Carbachol	18-27	mitogen-activated protein kinase 3	Homo sapiens	144-150
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	0-9	transient receptor potential cation channel subfamily C member 3	Homo sapiens	104-109
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	0-9	receptor for activated C kinase 1	Homo sapiens	110-115
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	0-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	116-122
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	0-9	transient receptor potential cation channel subfamily C member 3	Homo sapiens	104-109
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	11-14	transient receptor potential cation channel subfamily C member 3	Homo sapiens	65-70
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	11-14	transient receptor potential cation channel subfamily C member 3	Homo sapiens	104-109
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	11-14	receptor for activated C kinase 1	Homo sapiens	110-115
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	11-14	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	116-122
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	11-14	transient receptor potential cation channel subfamily C member 3	Homo sapiens	104-109
18755685-6	2008	CCh-stimulated recruitment of TRPC3-RACK1-IP(3)R complex as well as increased surface expression of TRPC3 and receptor-operated Ca(2+) entry were also attenuated.	Carbachol	0-3	transient receptor potential cation channel subfamily C member 3	Homo sapiens	30-35
18755685-6	2008	CCh-stimulated recruitment of TRPC3-RACK1-IP(3)R complex as well as increased surface expression of TRPC3 and receptor-operated Ca(2+) entry were also attenuated.	Carbachol	0-3	receptor for activated C kinase 1	Homo sapiens	36-41
18755685-6	2008	CCh-stimulated recruitment of TRPC3-RACK1-IP(3)R complex as well as increased surface expression of TRPC3 and receptor-operated Ca(2+) entry were also attenuated.	Carbachol	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	42-48
18755685-6	2008	CCh-stimulated recruitment of TRPC3-RACK1-IP(3)R complex as well as increased surface expression of TRPC3 and receptor-operated Ca(2+) entry were also attenuated.	Carbachol	0-3	transient receptor potential cation channel subfamily C member 3	Homo sapiens	100-105
18755685-8	2008	Knockdown of endogenous TRPC3 also decreased RACK1-IP(3)R association and decreased CCh-stimulated Ca(2+) entry.	Carbachol	84-87	transient receptor potential cation channel subfamily C member 3	Homo sapiens	24-29
18755685-10	2008	Similar oscillatory pattern of Ca(2+) release was seen after CCh stimulation of cells expressing the TRPC3 mutant.	Carbachol	61-64	transient receptor potential cation channel subfamily C member 3	Homo sapiens	101-106
18755690-8	2008	Exposure of astrocytes to carbachol increased the expression of the extracellular matrix proteins fibronectin and laminin-1 in these cells.	Carbachol	26-35	fibronectin 1	Rattus norvegicus	98-109
18755690-8	2008	Exposure of astrocytes to carbachol increased the expression of the extracellular matrix proteins fibronectin and laminin-1 in these cells.	Carbachol	26-35	laminin subunit alpha 1	Rattus norvegicus	114-123
18755690-10	2008	The inhibition of fibronectin activity strongly reduced the effect of carbachol on the elongation of all the neurites, whereas inhibition of laminin-1 activity reduced the elongation of minor neurites only.	Carbachol	70-79	fibronectin 1	Rattus norvegicus	18-29
18768927-3	2008	The present study demonstrates that chronic exposure of polarized rat parotid gland (Par-C10) epithelial cell monolayers to TNF-alpha and IFN-gamma decreases transepithelial resistance (TER) and anion secretion, as measured by changes in short-circuit current (I(sc)) induced by carbachol, a muscarinic cholinergic receptor agonist, or UTP, a P2Y(2) nucleotide receptor agonist.	Carbachol	279-288	tumor necrosis factor	Rattus norvegicus	124-133
18768927-3	2008	The present study demonstrates that chronic exposure of polarized rat parotid gland (Par-C10) epithelial cell monolayers to TNF-alpha and IFN-gamma decreases transepithelial resistance (TER) and anion secretion, as measured by changes in short-circuit current (I(sc)) induced by carbachol, a muscarinic cholinergic receptor agonist, or UTP, a P2Y(2) nucleotide receptor agonist.	Carbachol	279-288	interferon gamma	Rattus norvegicus	138-147
18929546-5	2008	The three ligands all induced a reversible increase in firing, however, only carbachol-induced increase in firing was attenuated by the PKC inhibitors chelerythrine or GF 109203X.	Carbachol	77-86	proline rich transmembrane protein 2	Homo sapiens	136-139
18929546-9	2008	Furthermore, preincubation with the PKC inhibitor GF 109203X reduced the carbachol-induced increase in nifedipine-sensitive high-voltage gated calcium currents.	Carbachol	73-82	proline rich transmembrane protein 2	Homo sapiens	36-39
18617156-7	2008	Difference between basal release and carbachol-induced secretion achieved statistical significance as to all the proteins/peptides under study but for statherin.	Carbachol	37-46	statherin	Homo sapiens	151-160
18815229-8	2008	Carbachol and PMA likewise caused redistribution of NBCe1 from BLM to early endosomes.	Carbachol	0-9	solute carrier family 4 member 4 S homeolog	Xenopus laevis	52-57
18755685-4	2008	Carbachol (CCh) stimulation of HEK293 cells expressing wild type TRPC3 induced recruitment of a ternary TRPC3-RACK1-IP(3)R complex and increased surface expression of TRPC3 and Ca(2+) entry.	Carbachol	0-9	transient receptor potential cation channel subfamily C member 3	Homo sapiens	65-70
18567601-6	2008	In parietal cells of cultured gastric glands from wild-type mice treated with gastrin, histamine or carbachol, ezrin was localized to vesicular structures resembling secretory canaliculi.	Carbachol	100-109	ezrin	Mus musculus	111-116
18772167-6	2008	Brief exposure of INGAP-PP-treated islets to carbachol (Cch) significantly increased P70S6K(-Thr389) and MAPK3/1 phosphorylation and these islets released more insulin when challenged with Cch that was prevented by the M3 receptor antagonist 4-DAMP, in a concentration-dependent manner.	Carbachol	45-54	ribosomal protein S6 kinase B1	Rattus norvegicus	85-91
18687805-2	2008	Thrombin also activates Ras homolog gene family member A (RhoA) and activating protein (AP-1) -mediated gene expression in 1321N1 astrocytoma cells, whereas the nonmitogenic agonist carbachol does not.	Carbachol	182-191	coagulation factor II, thrombin	Homo sapiens	0-8
18722532-5	2008	First we show that the PDBu- and carbachol-stimulated N1 secretions are blocked by the general PKC inhibitor GF109203X.	Carbachol	33-42	protein kinase C alpha	Homo sapiens	95-98
18772167-6	2008	Brief exposure of INGAP-PP-treated islets to carbachol (Cch) significantly increased P70S6K(-Thr389) and MAPK3/1 phosphorylation and these islets released more insulin when challenged with Cch that was prevented by the M3 receptor antagonist 4-DAMP, in a concentration-dependent manner.	Carbachol	45-54	mitogen activated protein kinase 3	Rattus norvegicus	105-110
18772167-6	2008	Brief exposure of INGAP-PP-treated islets to carbachol (Cch) significantly increased P70S6K(-Thr389) and MAPK3/1 phosphorylation and these islets released more insulin when challenged with Cch that was prevented by the M3 receptor antagonist 4-DAMP, in a concentration-dependent manner.	Carbachol	56-59	ribosomal protein S6 kinase B1	Rattus norvegicus	85-91
18772167-6	2008	Brief exposure of INGAP-PP-treated islets to carbachol (Cch) significantly increased P70S6K(-Thr389) and MAPK3/1 phosphorylation and these islets released more insulin when challenged with Cch that was prevented by the M3 receptor antagonist 4-DAMP, in a concentration-dependent manner.	Carbachol	56-59	mitogen activated protein kinase 3	Rattus norvegicus	105-110
18774166-4	2008	METHODS: beta(2)-AR responsiveness to isoproterenol was characterized in human precision-cut lung slices (PCLSs) precontracted to carbachol after pretreatment with albuterol.	Carbachol	130-139	adrenoceptor beta 2	Homo sapiens	9-19
18828925-13	2008	Double labeling demonstrated that a number of AVP- and OT-containing neurons in the fetal SON and PVN were expressing c-fos in response to central carbachol.	Carbachol	147-156	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-123
18602908-0	2008	Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis.	Carbachol	27-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-62
18602908-5	2008	Here we show that the reaction of carbachol (carbamoylcholine) with AChE can be monitored both with acetylthiocholine as a reporter substrate and with thioflavin T as a fluorescent reporter group.	Carbachol	34-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
18602908-5	2008	Here we show that the reaction of carbachol (carbamoylcholine) with AChE can be monitored both with acetylthiocholine as a reporter substrate and with thioflavin T as a fluorescent reporter group.	Carbachol	45-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
18524939-4	2008	The dependence of force on MLCK activity was nonlinear such that at higher concentrations of CCh, force increased with no change in the net 20% activation of MLCK.	Carbachol	93-96	myosin light chain kinase 3	Mus musculus	27-31
18632735-1	2008	We previously found that the phosphorylation of ERK1/2 by submaximal concentrations of the muscarinic receptor ligand carbachol was potentiated in rat parotid acinar cells exposed to ouabain, a cardiac glycoside that inhibits the Na-K-ATPase.	Carbachol	118-127	mitogen activated protein kinase 3	Rattus norvegicus	48-54
18758068-4	2008	TRPC5 was initially activated by muscarinic stimulation using 50 microM carbachol (CCh) and decayed rapidly in the presence of CCh (desensitization).	Carbachol	72-81	transient receptor potential cation channel subfamily C member 5	Homo sapiens	0-5
18758068-4	2008	TRPC5 was initially activated by muscarinic stimulation using 50 microM carbachol (CCh) and decayed rapidly in the presence of CCh (desensitization).	Carbachol	83-86	transient receptor potential cation channel subfamily C member 5	Homo sapiens	0-5
18758068-4	2008	TRPC5 was initially activated by muscarinic stimulation using 50 microM carbachol (CCh) and decayed rapidly in the presence of CCh (desensitization).	Carbachol	127-130	transient receptor potential cation channel subfamily C member 5	Homo sapiens	0-5
18758068-11	2008	In mouse ileal myocytes, the desensitization of CCh-activated inward current (I(CCh)) also slowed in the presence of PIP(2) in recording pipettes.	Carbachol	48-51	prolactin induced protein	Mus musculus	117-120
18758068-11	2008	In mouse ileal myocytes, the desensitization of CCh-activated inward current (I(CCh)) also slowed in the presence of PIP(2) in recording pipettes.	Carbachol	80-83	prolactin induced protein	Mus musculus	117-120
18627437-4	2008	Stable and transient depletion of CIB1 by short-hairpin RNA increased the Ca2+ response of HEK293 cells to the InsP3-generating ligands ATP, UTP and carbachol.	Carbachol	149-158	calcium and integrin binding 1	Homo sapiens	34-38
18632735-8	2008	These results suggest that carbachol-initiated AMPK activation can produce a negative feedback on ERK1/2 signaling in response to submaximal muscarinic receptor activation and that increases in fluid secretion can modulate receptor-initiated signaling events indirectly by producing ion transport-dependent decreases in ATP.	Carbachol	27-36	mitogen activated protein kinase 3	Rattus norvegicus	98-104
18617565-2	2008	Cationic currents due to TRPC6 expression were strongly suppressed (by approximately 70%) by a NO donor SNAP (100 microm) whether it was applied prior to muscarinic receptor stimulation with carbachol (CCh; 100 microm) or after G-protein activation with intracellular perfusion of GTPgammaS (100 microm).	Carbachol	191-200	transient receptor potential cation channel subfamily C member 6	Homo sapiens	25-30
18617565-2	2008	Cationic currents due to TRPC6 expression were strongly suppressed (by approximately 70%) by a NO donor SNAP (100 microm) whether it was applied prior to muscarinic receptor stimulation with carbachol (CCh; 100 microm) or after G-protein activation with intracellular perfusion of GTPgammaS (100 microm).	Carbachol	202-205	transient receptor potential cation channel subfamily C member 6	Homo sapiens	25-30
18577515-5	2008	Stimulation with cholecystokinin (CCK), carbachol, and vasoactive intestinal peptide all induced Rap1 activation, as did calcium ionophore A23187, phorbol ester, forskolin, 8-bromo-cyclic AMP, and the Epac-specific cAMP analog 8-pCPT-2"-O-Me-cAMP.	Carbachol	40-49	RAS-related protein 1a	Mus musculus	97-101
18577515-5	2008	Stimulation with cholecystokinin (CCK), carbachol, and vasoactive intestinal peptide all induced Rap1 activation, as did calcium ionophore A23187, phorbol ester, forskolin, 8-bromo-cyclic AMP, and the Epac-specific cAMP analog 8-pCPT-2"-O-Me-cAMP.	Carbachol	40-49	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	201-205
18577515-7	2008	Co-stimulation with carbachol and 8-pCPT-2"-O-Me-cAMP led to an additive effect on Rap1 activation, whereas a synergistic effect was seen on amylase release.	Carbachol	20-29	RAS-related protein 1a	Mus musculus	83-87
18577515-9	2008	Overexpression of Rap1 GTPase-activating protein, which blocked Rap1 activation, reduced the effect of 8-bromo-cyclic AMP, 8-pCPT-2"-O-Me-cAMP, and vasoactive intestinal peptide on amylase release by 60% and reduced CCK- as well as carbachol-stimulated pancreatic amylase release by 40%.	Carbachol	232-241	RAS-related protein 1a	Mus musculus	18-22
18577515-9	2008	Overexpression of Rap1 GTPase-activating protein, which blocked Rap1 activation, reduced the effect of 8-bromo-cyclic AMP, 8-pCPT-2"-O-Me-cAMP, and vasoactive intestinal peptide on amylase release by 60% and reduced CCK- as well as carbachol-stimulated pancreatic amylase release by 40%.	Carbachol	232-241	RAS-related protein 1a	Mus musculus	64-68
18577515-9	2008	Overexpression of Rap1 GTPase-activating protein, which blocked Rap1 activation, reduced the effect of 8-bromo-cyclic AMP, 8-pCPT-2"-O-Me-cAMP, and vasoactive intestinal peptide on amylase release by 60% and reduced CCK- as well as carbachol-stimulated pancreatic amylase release by 40%.	Carbachol	232-241	cholecystokinin	Mus musculus	216-219
18577515-11	2008	Rap1 activation not only mediates the cAMP-evoked response via Epac1 but is also involved in CCK- and carbachol-induced amylase release, with their action most likely mediated by CalDAG-GEF III.	Carbachol	102-111	RAS-related protein 1a	Mus musculus	0-4
18658048-8	2008	Finally, RGS4-null SAN cells showed decreased levels of G protein-coupled inward rectifying potassium (GIRK) channel desensitization and altered modulation of acetylcholine-sensitive potassium current (I(KACh)) kinetics following carbachol stimulation.	Carbachol	230-239	regulator of G-protein signaling 4	Mus musculus	9-13
18524858-10	2008	The decrease in cGMP response to carbamyl-choline (eNOS agonist) was significantly attenuated by rosiglitazone in CRF.	Carbachol	33-49	nitric oxide synthase 3	Rattus norvegicus	51-55
18524939-7	2008	CCh treatment, but not KCl, resulted in MYPT1 and CPI-17 phosphorylation.	Carbachol	0-3	protein phosphatase 1, regulatory subunit 12A	Mus musculus	40-45
18524939-7	2008	CCh treatment, but not KCl, resulted in MYPT1 and CPI-17 phosphorylation.	Carbachol	0-3	protein phosphatase 1, regulatory inhibitor subunit 14A	Mus musculus	50-56
18524939-8	2008	Both Y27632 (Rho-kinase inhibitor) and calphostin C (PKC inhibitor) reduced CCh-dependent force, RLC phosphorylation, and phosphorylation of MYPT1 (Thr694) without changing MLCK activation.	Carbachol	76-79	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	13-23
18524939-8	2008	Both Y27632 (Rho-kinase inhibitor) and calphostin C (PKC inhibitor) reduced CCh-dependent force, RLC phosphorylation, and phosphorylation of MYPT1 (Thr694) without changing MLCK activation.	Carbachol	76-79	myosin light chain kinase 3	Mus musculus	173-177
18524939-9	2008	Calphostin C, but not Y27632, also reduced CCh-induced phosphorylation of CPI-17.	Carbachol	43-46	protein phosphatase 1, regulatory inhibitor subunit 14A	Mus musculus	74-80
18524939-10	2008	CCh concentration responses showed that phosphorylation of CPI-17 was more sensitive than MYPT1.	Carbachol	0-3	protein phosphatase 1, regulatory inhibitor subunit 14A	Mus musculus	59-65
18524939-10	2008	CCh concentration responses showed that phosphorylation of CPI-17 was more sensitive than MYPT1.	Carbachol	0-3	protein phosphatase 1, regulatory subunit 12A	Mus musculus	90-95
18300276-5	2008	Among agents tested, carbachol and gastrin were strong inhibitors of RELMbeta mRNA accumulation.	Carbachol	21-30	resistin like beta	Homo sapiens	69-77
18348264-4	2008	In SK-N-SH cells, the acetylcholine analog carbachol stimulated phosphorylation of the ribosomal S6 protein, a downstream target of mTOR.	Carbachol	43-52	mechanistic target of rapamycin kinase	Homo sapiens	132-136
18348264-6	2008	Carbachol-evoked S6 phosphorylation was blocked by the mTOR inhibitor rapamycin, but was independent of phosphoinositide 3-kinase activation.	Carbachol	0-9	mechanistic target of rapamycin kinase	Homo sapiens	55-59
18434623-4	2008	Upon stimulation of secretion with the muscarinic agonist, carbachol, Myo5c was also detected in association with actin-coated fusion intermediates.	Carbachol	59-68	unconventional myosin-Vc	Oryctolagus cuniculus	70-75
18434623-8	2008	These studies revealed that the carbachol-stimulated increase in secretory vesicle diameter associated with compound fusion of secretory vesicles that was also exhibited by vesicles labeled with GFP-Myo5c-full was impaired in vesicles labeled with GFP-Myo5c-tail.	Carbachol	32-41	unconventional myosin-Vc	Oryctolagus cuniculus	199-204
18434623-8	2008	These studies revealed that the carbachol-stimulated increase in secretory vesicle diameter associated with compound fusion of secretory vesicles that was also exhibited by vesicles labeled with GFP-Myo5c-full was impaired in vesicles labeled with GFP-Myo5c-tail.	Carbachol	32-41	unconventional myosin-Vc	Oryctolagus cuniculus	252-257
18434623-9	2008	A significant decrease in GFP labeling of actin-coated fusion intermediates was also seen in carbachol-stimulated LGAC transduced with GFP-Myo5c-tail relative to LGAC transduced with GFP-Myo5c-full.	Carbachol	93-102	unconventional myosin-Vc	Oryctolagus cuniculus	139-144
18434623-9	2008	A significant decrease in GFP labeling of actin-coated fusion intermediates was also seen in carbachol-stimulated LGAC transduced with GFP-Myo5c-tail relative to LGAC transduced with GFP-Myo5c-full.	Carbachol	93-102	unconventional myosin-Vc	Oryctolagus cuniculus	187-192
18316702-10	2008	mRNA and protein for TRPC1 and TRPC6 were present in mouse Muller cells, and carbachol activated a Gd(3+)-sensitive, TRP-like cation channel.	Carbachol	77-86	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	21-26
18436530-2	2008	Here we demonstrate that the muscarinic receptor agonist carbachol activates AMPKalpha1-containing complexes in the human SH-SY5Y cell line via a mechanism specific for the AMPK upstream kinase, Ca(2+)/calmodulin-dependent protein kinase kinase beta.	Carbachol	57-66	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	77-87
18436530-2	2008	Here we demonstrate that the muscarinic receptor agonist carbachol activates AMPKalpha1-containing complexes in the human SH-SY5Y cell line via a mechanism specific for the AMPK upstream kinase, Ca(2+)/calmodulin-dependent protein kinase kinase beta.	Carbachol	57-66	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	77-81
18388243-3	2008	We show that knockdown of GRK2, GRK3, or GRK6, but not GRK5, significantly increased carbachol-mediated calcium mobilization.	Carbachol	85-94	G protein-coupled receptor kinase 2	Homo sapiens	26-30
18388243-6	2008	Knockdown of GRK2 and the arrestins also significantly enhanced carbachol-mediated activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), whereas prolonged ERK1/2 activation was only observed with GRK2 or arrestin-3 knockdown.	Carbachol	64-73	G protein-coupled receptor kinase 2	Homo sapiens	13-17
18385290-0	2008	Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line.	Carbachol	79-88	mitogen-activated protein kinase 1	Homo sapiens	21-24
18385290-2	2008	We examined the activation of ERK1/2 by two muscarinic agonists, pilocarpine and carbachol, in a human salivary cell line (HSY).	Carbachol	81-90	mitogen-activated protein kinase 3	Homo sapiens	30-36
18385290-6	2008	Downregulation of PKC by prolonged treatment of cells with the phorbol ester PMA diminished carbachol-induced ERK phosphorylation but had no effect on pilocarpine responsiveness.	Carbachol	92-101	mitogen-activated protein kinase 1	Homo sapiens	110-113
18385290-12	2008	Our results demonstrate that the actions of pilocarpine and carbachol in salivary cells are mediated through two distinct signaling mechanisms-pilocarpine acting via M3 receptors and Src-dependent transactivation of EGF receptors, and carbachol via M1/M3 receptors and PKC-converging on the ERK pathway.	Carbachol	60-69	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	183-186
18385290-12	2008	Our results demonstrate that the actions of pilocarpine and carbachol in salivary cells are mediated through two distinct signaling mechanisms-pilocarpine acting via M3 receptors and Src-dependent transactivation of EGF receptors, and carbachol via M1/M3 receptors and PKC-converging on the ERK pathway.	Carbachol	60-69	mitogen-activated protein kinase 1	Homo sapiens	291-294
18388188-5	2008	The apical-to-basal carbachol (1 muM)-stimulated Ca(2+) wave was 8.63 +/- 0.68 microm/s; it increased to 19.66 +/- 2.22 microm/s (*P &lt; 0.0005) with VIP (100 nM), and similar increases were observed with 8-Br-cAMP (100 microM).	Carbachol	20-29	vasoactive intestinal peptide	Rattus norvegicus	151-154
18437352-8	2008	Weak, Ca(2+)-dependent stimulation with ionomycin or carbachol induced exclusive release of chromogranin B, suggesting a higher Ca(2+) sensitivity of the specific granules.	Carbachol	53-62	chromogranin B	Homo sapiens	92-106
18440028-0	2008	K+ACh channel activation with carbachol increases atrial ANP release.	Carbachol	30-39	natriuretic peptides A	Oryctolagus cuniculus	57-60
18298664-4	2008	The mixed nAChR-mAChR agonists acetylcholine (ACh) and carbachol provoked [(3)H]DA release partially sensitive to the mAChR antagonist atropine but totally blocked by the nAChR antagonist mecamylamine.	Carbachol	55-64	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	10-15
18298664-4	2008	The mixed nAChR-mAChR agonists acetylcholine (ACh) and carbachol provoked [(3)H]DA release partially sensitive to the mAChR antagonist atropine but totally blocked by the nAChR antagonist mecamylamine.	Carbachol	55-64	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	171-176
18440028-4	2008	Carbachol (CCh), an agonist of cardiac mAChR, increased atrial myocyte ANP release concomitantly with a decrease in stroke volume and intra-atrial pulse pressure in a concentration-dependent manner.	Carbachol	0-9	natriuretic peptides A	Oryctolagus cuniculus	71-74
18440028-4	2008	Carbachol (CCh), an agonist of cardiac mAChR, increased atrial myocyte ANP release concomitantly with a decrease in stroke volume and intra-atrial pulse pressure in a concentration-dependent manner.	Carbachol	11-14	natriuretic peptides A	Oryctolagus cuniculus	71-74
18440028-6	2008	In the presence of isoproterenol, the CCh-induced increase in ANP release and decrease in cAMP efflux levels and mechanical dynamics were able to be repeated.	Carbachol	38-41	natriuretic peptides A	Oryctolagus cuniculus	62-65
18440028-8	2008	Tertiapin, a selective G-protein-gated K(+)(ACh) channel blocker, attenuated the CCh-induced increase in ANP release and decrease in mechanical dynamics in a concentration-dependent manner, but without a significant effect on the CCh-induced decrease in cAMP efflux levels.	Carbachol	81-84	natriuretic peptides A	Oryctolagus cuniculus	105-108
18440028-9	2008	The CCh-induced changes in ANP release and atrial dynamics were inhibited in the atria from pertussis toxin-pretreated rabbits.	Carbachol	4-7	natriuretic peptides A	Oryctolagus cuniculus	27-30
18406062-9	2008	Furthermore activation of the ERK pathway by ex vivo cholinergic stimulation with carbachol caused significantly higher activation of ERK in the hippocampus of Wt mice than in Tg mice.	Carbachol	82-91	mitogen-activated protein kinase 1	Mus musculus	30-33
18406062-9	2008	Furthermore activation of the ERK pathway by ex vivo cholinergic stimulation with carbachol caused significantly higher activation of ERK in the hippocampus of Wt mice than in Tg mice.	Carbachol	82-91	mitogen-activated protein kinase 1	Mus musculus	134-137
18204473-6	2008	KEY RESULTS: TRPC5 activation by carbachol, Gd3+ or LPC was inhibited by halothane and chloroform at &gt; or =0.1 and 0.2 mM respectively.	Carbachol	33-42	transient receptor potential cation channel subfamily C member 5	Homo sapiens	13-18
18434353-5	2008	Activation of the endogenously expressed M3 receptor by the cholinergic agonist carbachol also potentiated CRH-induced insulin secretion, indicating that the phenomenon may be pathway specific (i.e. Ca2+-phospholipase C) rather than agonist specific.	Carbachol	80-89	corticotropin releasing hormone	Mus musculus	107-110
18171724-7	2008	Adenovirus-mediated overexpression of mutant Rab3DT36N in LGACs inhibited CCH-stimulated SC release, and, in CCH-stimulated LGACs, pull down of pIgR with Rab3DWT and colocalization of pIgR with endogenous Rab3D were decreased relative to resting cells, suggesting that the pIgR-Rab3D interaction may be modulated by secretagogues.	Carbachol	74-77	ras-related protein Rab-3D	Oryctolagus cuniculus	45-50
18171724-7	2008	Adenovirus-mediated overexpression of mutant Rab3DT36N in LGACs inhibited CCH-stimulated SC release, and, in CCH-stimulated LGACs, pull down of pIgR with Rab3DWT and colocalization of pIgR with endogenous Rab3D were decreased relative to resting cells, suggesting that the pIgR-Rab3D interaction may be modulated by secretagogues.	Carbachol	109-112	polymeric immunoglobulin receptor	Oryctolagus cuniculus	144-148
18171724-7	2008	Adenovirus-mediated overexpression of mutant Rab3DT36N in LGACs inhibited CCH-stimulated SC release, and, in CCH-stimulated LGACs, pull down of pIgR with Rab3DWT and colocalization of pIgR with endogenous Rab3D were decreased relative to resting cells, suggesting that the pIgR-Rab3D interaction may be modulated by secretagogues.	Carbachol	109-112	ras-related protein Rab-3D	Oryctolagus cuniculus	45-50
18457815-7	2008	In another set of experiments, the specific NK1 receptor antagonist L-703,606 (5 microg) was microinjected in the RVM following LH stimulation with carbachol and abolished LH-induced antinociception as well.	Carbachol	148-157	tachykinin receptor 1	Rattus norvegicus	44-56
18276774-4	2008	Tracheal smooth muscle contractility is enhanced by overnight incubation with IL-13, resulting in increased maximal contractions (E(max)) to carbachol (CCh) and KCl.	Carbachol	141-150	interleukin 13	Mus musculus	78-83
18276774-4	2008	Tracheal smooth muscle contractility is enhanced by overnight incubation with IL-13, resulting in increased maximal contractions (E(max)) to carbachol (CCh) and KCl.	Carbachol	152-155	interleukin 13	Mus musculus	78-83
18379433-6	2008	Carbachol-stimulated release of intracellular calcium is significantly higher in cells expressing N-terminal mutant huntingtin and TG2 compared with vector-transfected cells; expression of either CaM-center or CaM-overlap in these cells returned the levels of carbachol-stimulated intracellular calcium release to control values.	Carbachol	0-9	huntingtin	Homo sapiens	116-126
18379433-6	2008	Carbachol-stimulated release of intracellular calcium is significantly higher in cells expressing N-terminal mutant huntingtin and TG2 compared with vector-transfected cells; expression of either CaM-center or CaM-overlap in these cells returned the levels of carbachol-stimulated intracellular calcium release to control values.	Carbachol	0-9	calmodulin 1	Homo sapiens	196-199
18379433-6	2008	Carbachol-stimulated release of intracellular calcium is significantly higher in cells expressing N-terminal mutant huntingtin and TG2 compared with vector-transfected cells; expression of either CaM-center or CaM-overlap in these cells returned the levels of carbachol-stimulated intracellular calcium release to control values.	Carbachol	0-9	calmodulin 1	Homo sapiens	210-213
18379433-6	2008	Carbachol-stimulated release of intracellular calcium is significantly higher in cells expressing N-terminal mutant huntingtin and TG2 compared with vector-transfected cells; expression of either CaM-center or CaM-overlap in these cells returned the levels of carbachol-stimulated intracellular calcium release to control values.	Carbachol	260-269	calmodulin 1	Homo sapiens	196-199
18379433-6	2008	Carbachol-stimulated release of intracellular calcium is significantly higher in cells expressing N-terminal mutant huntingtin and TG2 compared with vector-transfected cells; expression of either CaM-center or CaM-overlap in these cells returned the levels of carbachol-stimulated intracellular calcium release to control values.	Carbachol	260-269	calmodulin 1	Homo sapiens	210-213
17581530-8	2008	Abeta 1-40 in absence of neurotoxicity fully inhibited the DA release evoked by CCh and only marginally affected the DA release evoked by epibatidine.	Carbachol	80-83	amyloid beta precursor protein	Homo sapiens	0-5
17581530-9	2008	The PKC inhibitor GF109203X mimicked the effect of Abeta on DA release and, in turn, Abeta impaired PKC activation by CCh.	Carbachol	118-121	amyloid beta precursor protein	Homo sapiens	51-56
18155849-0	2008	Fos expression in pontomedullary catecholaminergic cells following rapid eye movement sleep-like episodes elicited by pontine carbachol in urethane-anesthetized rats.	Carbachol	126-135	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
18155849-5	2008	The percentage of Fos-positive TH cells was negatively correlated with the cumulative duration of REMS-like episodes induced during 140 min prior to brain harvesting in the A7 and rostral A5 groups bilaterally (P &lt; 0.01 for both), and in SubC neurons on the side opposite to carbachol injection (P &lt; 0.05).	Carbachol	278-287	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-21
18344611-2	2008	In the present study, we showed that a muscarinic receptor agonist, carbachol (CCh), activates almost 20% of orexin-producing neurons (orexin neurons), which play a critical role in maintenance of arousal.	Carbachol	68-77	hypocretin	Mus musculus	109-115
18344611-2	2008	In the present study, we showed that a muscarinic receptor agonist, carbachol (CCh), activates almost 20% of orexin-producing neurons (orexin neurons), which play a critical role in maintenance of arousal.	Carbachol	68-77	hypocretin	Mus musculus	135-141
18344611-2	2008	In the present study, we showed that a muscarinic receptor agonist, carbachol (CCh), activates almost 20% of orexin-producing neurons (orexin neurons), which play a critical role in maintenance of arousal.	Carbachol	79-82	hypocretin	Mus musculus	109-115
18344611-2	2008	In the present study, we showed that a muscarinic receptor agonist, carbachol (CCh), activates almost 20% of orexin-producing neurons (orexin neurons), which play a critical role in maintenance of arousal.	Carbachol	79-82	hypocretin	Mus musculus	135-141
18344611-3	2008	We also found that a very small population of orexin neurons (1%) was inhibited by CCh.	Carbachol	83-86	hypocretin	Mus musculus	46-52
18344611-4	2008	Muscarinic receptor antagonists inhibited the CCh-induced activation of orexin neurons in a dose-dependent manner.	Carbachol	46-49	hypocretin	Mus musculus	72-78
18344611-8	2008	These results indicate that CCh activates 20% of orexin neurons through the M(3) muscarinic receptor and subsequent activation of nonselective cation channels.	Carbachol	28-31	hypocretin	Mus musculus	49-55
18155321-2	2008	Here, the effect of the muscarinic agonist carbachol on NPY biosynthesis and release was analyzed utilizing the SH-SY5Y human neuroblastoma cell line.	Carbachol	43-52	neuropeptide Y	Homo sapiens	56-59
18310132-7	2008	Using local photolysis of caged carbachol, a broad-spectrum cholinergic agonist, we mapped alpha7 nAChR-mediated currents along the visible extent of filled SNr neurons and found that alpha7 nAChRs can be functionally detected as far as 60 microm away from the soma.	Carbachol	32-41	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	98-103
18155321-3	2008	We observed that: (a) carbachol moderately increased the post-translational cleavage of proNPY to NPY; (b) carbachol treatment stimulated NPY accumulation into the medium in a time- and dose-related manner; (c) protein kinase C activation is involved in carbachol-mediated NPY synthesis/release (&gt;6h).	Carbachol	22-31	neuropeptide Y	Homo sapiens	91-94
18155321-3	2008	We observed that: (a) carbachol moderately increased the post-translational cleavage of proNPY to NPY; (b) carbachol treatment stimulated NPY accumulation into the medium in a time- and dose-related manner; (c) protein kinase C activation is involved in carbachol-mediated NPY synthesis/release (&gt;6h).	Carbachol	22-31	neuropeptide Y	Homo sapiens	98-101
18155321-3	2008	We observed that: (a) carbachol moderately increased the post-translational cleavage of proNPY to NPY; (b) carbachol treatment stimulated NPY accumulation into the medium in a time- and dose-related manner; (c) protein kinase C activation is involved in carbachol-mediated NPY synthesis/release (&gt;6h).	Carbachol	22-31	neuropeptide Y	Homo sapiens	98-101
18155321-3	2008	We observed that: (a) carbachol moderately increased the post-translational cleavage of proNPY to NPY; (b) carbachol treatment stimulated NPY accumulation into the medium in a time- and dose-related manner; (c) protein kinase C activation is involved in carbachol-mediated NPY synthesis/release (&gt;6h).	Carbachol	107-116	neuropeptide Y	Homo sapiens	91-94
18155321-3	2008	We observed that: (a) carbachol moderately increased the post-translational cleavage of proNPY to NPY; (b) carbachol treatment stimulated NPY accumulation into the medium in a time- and dose-related manner; (c) protein kinase C activation is involved in carbachol-mediated NPY synthesis/release (&gt;6h).	Carbachol	107-116	neuropeptide Y	Homo sapiens	98-101
18155321-3	2008	We observed that: (a) carbachol moderately increased the post-translational cleavage of proNPY to NPY; (b) carbachol treatment stimulated NPY accumulation into the medium in a time- and dose-related manner; (c) protein kinase C activation is involved in carbachol-mediated NPY synthesis/release (&gt;6h).	Carbachol	107-116	neuropeptide Y	Homo sapiens	98-101
18155321-3	2008	We observed that: (a) carbachol moderately increased the post-translational cleavage of proNPY to NPY; (b) carbachol treatment stimulated NPY accumulation into the medium in a time- and dose-related manner; (c) protein kinase C activation is involved in carbachol-mediated NPY synthesis/release (&gt;6h).	Carbachol	107-116	neuropeptide Y	Homo sapiens	91-94
18155321-3	2008	We observed that: (a) carbachol moderately increased the post-translational cleavage of proNPY to NPY; (b) carbachol treatment stimulated NPY accumulation into the medium in a time- and dose-related manner; (c) protein kinase C activation is involved in carbachol-mediated NPY synthesis/release (&gt;6h).	Carbachol	107-116	neuropeptide Y	Homo sapiens	98-101
18155321-3	2008	We observed that: (a) carbachol moderately increased the post-translational cleavage of proNPY to NPY; (b) carbachol treatment stimulated NPY accumulation into the medium in a time- and dose-related manner; (c) protein kinase C activation is involved in carbachol-mediated NPY synthesis/release (&gt;6h).	Carbachol	107-116	neuropeptide Y	Homo sapiens	98-101
18037403-15	2008	Carbachol-induced phosphorylation of CPI-17 was also reduced in colonic segments from TNBS-treated rats.	Carbachol	0-9	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	37-43
17920706-4	2008	In endothelin-1 or carbachol-contracted mucosal muscle strips, CNP caused moderate, sustained and concentration-dependent relaxation.	Carbachol	19-28	natriuretic peptide C	Homo sapiens	63-66
18061571-0	2008	Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by ERK, Elk-1, MKP-1, and calcineurin in carbachol-stimulated human neuroblastoma cells.	Carbachol	149-158	early growth response 1	Homo sapiens	89-94
18061571-0	2008	Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by ERK, Elk-1, MKP-1, and calcineurin in carbachol-stimulated human neuroblastoma cells.	Carbachol	149-158	mitogen-activated protein kinase 1	Homo sapiens	111-114
18061571-0	2008	Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by ERK, Elk-1, MKP-1, and calcineurin in carbachol-stimulated human neuroblastoma cells.	Carbachol	149-158	ETS transcription factor ELK1	Homo sapiens	116-121
18061571-0	2008	Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by ERK, Elk-1, MKP-1, and calcineurin in carbachol-stimulated human neuroblastoma cells.	Carbachol	149-158	dual specificity phosphatase 1	Homo sapiens	123-128
18061571-1	2008	Carbachol-mediated activation of type M(3) muscarinic acetylcholine receptors induces the biosynthesis of the transcription factor Egr-1 in human SH-SY5Y neuroblastoma cells involving an activation of extracellular signal-regulated protein kinase.	Carbachol	0-9	early growth response 1	Homo sapiens	131-136
18061571-2	2008	Carbachol triggered the phosphorylation of the ternary complex factor Elk-1, a key transcriptional regulator of serum response element-driven gene transcription, and strikingly enhanced the transcriptional activation potential of Elk-1.	Carbachol	0-9	ETS transcription factor ELK1	Homo sapiens	70-75
18061571-2	2008	Carbachol triggered the phosphorylation of the ternary complex factor Elk-1, a key transcriptional regulator of serum response element-driven gene transcription, and strikingly enhanced the transcriptional activation potential of Elk-1.	Carbachol	0-9	ETS transcription factor ELK1	Homo sapiens	230-235
18061571-5	2008	Lentiviral-mediated expression of either MAP kinase phosphatase-1 (MKP-1) or a constitutively active mutant of calcineurin A inhibited Egr-1 biosynthesis following carbachol stimulation, indicating that these phosphatases function as shut-off devices of muscarinic acetylcholine receptor signaling.	Carbachol	164-173	dual specificity phosphatase 1	Homo sapiens	41-65
18061571-5	2008	Lentiviral-mediated expression of either MAP kinase phosphatase-1 (MKP-1) or a constitutively active mutant of calcineurin A inhibited Egr-1 biosynthesis following carbachol stimulation, indicating that these phosphatases function as shut-off devices of muscarinic acetylcholine receptor signaling.	Carbachol	164-173	dual specificity phosphatase 1	Homo sapiens	67-72
18061571-5	2008	Lentiviral-mediated expression of either MAP kinase phosphatase-1 (MKP-1) or a constitutively active mutant of calcineurin A inhibited Egr-1 biosynthesis following carbachol stimulation, indicating that these phosphatases function as shut-off devices of muscarinic acetylcholine receptor signaling.	Carbachol	164-173	early growth response 1	Homo sapiens	135-140
18061571-7	2008	Expression experiments revealed that both MKP-1 and a constitutively active mutant of calcineurin A impaired carbachol-induced upregulation of AP-1 activity.	Carbachol	109-118	dual specificity phosphatase 1	Homo sapiens	42-47
18061571-8	2008	The fact that carbachol stimulation of neuroblastoma cells activates the transcription factors Egr-1 and AP-1 suggests that changes in the gene expression pattern are an integral part of muscarinic acetylcholine receptor signaling.	Carbachol	14-23	early growth response 1	Homo sapiens	95-100
18214744-2	2008	MATERIALS AND METHODS: Obestatin (10(-5) M) or ghrelin (10(-5) M) were tested on two consecutive carbachol-or epinephrine-elicited contractions of iris rabbit sphincter or dilator muscles.	Carbachol	97-106	LOC100101616	Oryctolagus cuniculus	47-54
18214744-4	2008	RESULTS: Compared with the first, tension of the second carbachol-induced contraction of the iris sphincter decreased 11.5+/-5.5% in the vehicle group, increased 19.0+/-10.2% in presence of obestatin, and remained unchanged by ghrelin.	Carbachol	56-65	LOC100101616	Oryctolagus cuniculus	227-234
17582410-6	2008	In isolated intestinal bulb and mid/distal intestine preparations, ghrelin, motilin, and the motilin receptor agonist erythromycin all evoked contraction; these responses ranged between 9% and 51% of the contractions evoked by carbachol (10(-6) M).	Carbachol	227-236	motilin	Rattus norvegicus	76-83
17582410-6	2008	In isolated intestinal bulb and mid/distal intestine preparations, ghrelin, motilin, and the motilin receptor agonist erythromycin all evoked contraction; these responses ranged between 9% and 51% of the contractions evoked by carbachol (10(-6) M).	Carbachol	227-236	motilin	Rattus norvegicus	93-100
18514752-3	2008	Using our pharmacodynamic model to assess ex vivo AHR isolated murine tracheal rings, we found that TNFalpha-induced enhanced contractile responses to carbachol and bradykinin was abrogated by neutralizing anti-IFNbeta antibody or in tracheal rings deficient in CD38.	Carbachol	151-160	tumor necrosis factor	Mus musculus	100-108
18514752-3	2008	Using our pharmacodynamic model to assess ex vivo AHR isolated murine tracheal rings, we found that TNFalpha-induced enhanced contractile responses to carbachol and bradykinin was abrogated by neutralizing anti-IFNbeta antibody or in tracheal rings deficient in CD38.	Carbachol	151-160	interferon beta 1, fibroblast	Mus musculus	211-218
18514752-3	2008	Using our pharmacodynamic model to assess ex vivo AHR isolated murine tracheal rings, we found that TNFalpha-induced enhanced contractile responses to carbachol and bradykinin was abrogated by neutralizing anti-IFNbeta antibody or in tracheal rings deficient in CD38.	Carbachol	151-160	CD38 antigen	Mus musculus	262-266
18514752-4	2008	In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin.	Carbachol	106-115	CD38 molecule	Homo sapiens	35-39
18514752-4	2008	In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin.	Carbachol	106-115	tumor necrosis factor	Homo sapiens	61-69
18514752-4	2008	In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin.	Carbachol	106-115	interferon beta 1, fibroblast	Mus musculus	164-171
18514752-4	2008	In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin.	Carbachol	106-115	tumor necrosis factor	Homo sapiens	182-190
18514752-4	2008	In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin.	Carbachol	216-225	tumor necrosis factor	Homo sapiens	61-69
18514752-4	2008	In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin.	Carbachol	216-225	interferon beta 1, fibroblast	Mus musculus	164-171
18514752-4	2008	In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin.	Carbachol	216-225	tumor necrosis factor	Homo sapiens	182-190
17540859-6	2008	In contrast, carbachol-induced internalization of mutant hM(1) receptors possessing either C259A/C260A or C262A/C263A or both double point mutations was significantly reduced compared to the wild-type hM(1) receptor.	Carbachol	13-22	cholinergic receptor muscarinic 1	Homo sapiens	57-62
17540859-6	2008	In contrast, carbachol-induced internalization of mutant hM(1) receptors possessing either C259A/C260A or C262A/C263A or both double point mutations was significantly reduced compared to the wild-type hM(1) receptor.	Carbachol	13-22	cholinergic receptor muscarinic 1	Homo sapiens	201-206
17540859-7	2008	Of the hM(1) receptor mutants tested, those possessing a C262D/C263D double point mutation had the least carbachol-induced internalization.	Carbachol	105-114	cholinergic receptor muscarinic 1	Homo sapiens	7-12
17689570-8	2008	IPSPs that are increased by carbachol (CCh-sIPSPs), are depressed by CCK, omega-conotoxin GVIA, and endocannabinoids.	Carbachol	28-37	cholecystokinin	Homo sapiens	69-72
17997396-4	2007	The influence of carbachol, a non-specific cholinergic agonist, on locomotor activity, c-fos expression in the SCN, and the activity of this structure has been previously studied.	Carbachol	17-26	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	87-92
17904551-13	2007	Endocytosed PRL was stored in intact form and released in response to stimulation with carbachol.	Carbachol	87-96	prolactin	Oryctolagus cuniculus	12-15
17919561-10	2007	Carbachol-stimulated MAPK activity was inhibited by three PKC inhibitors, calphostin C, chelethyrine, and staurosporine.	Carbachol	0-9	mitogen activated protein kinase 3	Rattus norvegicus	21-25
17618452-9	2007	Carbachol (100 microM) and forskolin (5 microM) stimulated gastric acid secretion to a similar extent in sgk1 (-/-) and sgk1 (+/+)mice.	Carbachol	0-9	serum/glucocorticoid regulated kinase 1	Mus musculus	105-109
17618452-9	2007	Carbachol (100 microM) and forskolin (5 microM) stimulated gastric acid secretion to a similar extent in sgk1 (-/-) and sgk1 (+/+)mice.	Carbachol	0-9	serum/glucocorticoid regulated kinase 1	Mus musculus	120-124
17687004-10	2007	DBcAMP and VIP inhibited carbachol- and EGF-stimulated MAPK activity.	Carbachol	25-34	vasoactive intestinal peptide	Rattus norvegicus	11-14
17687004-10	2007	DBcAMP and VIP inhibited carbachol- and EGF-stimulated MAPK activity.	Carbachol	25-34	mitogen activated protein kinase 3	Rattus norvegicus	55-59
17996892-5	2008	NPY reduced the heart rate response to vagal stimulation at 1, 3 and 5 Hz (significant at 100 nM and reaching a plateau at 250 nM NPY, p&lt;0.05, n=6) but not to the stable analogue of acetylcholine, carbamylcholine (30, 60 or 90 nM, n=6) which produced similar degrees of bradycardia.	Carbachol	200-215	pro-neuropeptide Y	Cavia porcellus	0-3
17998138-11	2008	Even though adenosine and CPA alone had only a moderate effect on secretion, the observed synergistic effect with carbachol suggests a modulatory role for the adenosine A1 receptor in the lacrimal gland.	Carbachol	114-123	adenosine receptor A1	Oryctolagus cuniculus	159-180
18306282-6	2008	We showed that carbachol activation of the MS-DB generated large theta oscillations in the CA1 and CA3 regions of the hippocampus.	Carbachol	15-24	carbonic anhydrase 1	Rattus norvegicus	91-94
18306282-6	2008	We showed that carbachol activation of the MS-DB generated large theta oscillations in the CA1 and CA3 regions of the hippocampus.	Carbachol	15-24	carbonic anhydrase 3	Rattus norvegicus	99-102
18184179-2	2008	METHODS: We have evaluated the effects of M-1 on the contractions induced by carbachol, KCl, CaCl(2), and electrical field stimulation (EFS) in human detrusor smooth muscles, and pelvic nerve stimulation-induced bladder contractions in rats.	Carbachol	77-86	myoregulin	Homo sapiens	42-45
18184179-5	2008	M-1 caused concentration-dependent reduction in the maximum contractile responses induced by carbachol.	Carbachol	93-102	myoregulin	Homo sapiens	0-3
17928569-8	2008	In the presence of M-2, the CCh-induced inhibition of I(Ca) was blocked.	Carbachol	28-31	cholinergic receptor, muscarinic 2, cardiac	Mus musculus	19-22
17925457-2	2008	Carbachol-activated TRPC5 currents were recorded by the whole-cell patch clamp technique from human embryonic kidney 293 cells transiently transfected with TRPC5 and the M1 muscarinic receptor.	Carbachol	0-9	transient receptor potential cation channel subfamily C member 5	Homo sapiens	20-25
17925457-2	2008	Carbachol-activated TRPC5 currents were recorded by the whole-cell patch clamp technique from human embryonic kidney 293 cells transiently transfected with TRPC5 and the M1 muscarinic receptor.	Carbachol	0-9	transient receptor potential cation channel subfamily C member 5	Homo sapiens	156-161
18066127-0	2007	Role of calmodulin and myosin light chain kinase in the activation of carbachol-activated cationic current in murine ileal myocytes.	Carbachol	70-79	calmodulin 2	Mus musculus	8-18
18066127-0	2007	Role of calmodulin and myosin light chain kinase in the activation of carbachol-activated cationic current in murine ileal myocytes.	Carbachol	70-79	myosin light chain kinase 3	Mus musculus	23-48
18066127-5	2007	The amplitude of I CCh was reduced by pretreatment either with W-7, trifluoroperazine, W-5, and melittin (CaM inhibitors) or with ML-7 and ML-9 (selective MLCK inhibitors), and the inhibitory effects were reversible.	Carbachol	19-22	calmodulin 2	Mus musculus	106-109
18066127-5	2007	The amplitude of I CCh was reduced by pretreatment either with W-7, trifluoroperazine, W-5, and melittin (CaM inhibitors) or with ML-7 and ML-9 (selective MLCK inhibitors), and the inhibitory effects were reversible.	Carbachol	19-22	solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16	Mus musculus	130-134
18066127-5	2007	The amplitude of I CCh was reduced by pretreatment either with W-7, trifluoroperazine, W-5, and melittin (CaM inhibitors) or with ML-7 and ML-9 (selective MLCK inhibitors), and the inhibitory effects were reversible.	Carbachol	19-22	myosin light chain kinase 3	Mus musculus	155-159
18066127-8	2007	We conclude that CaM and MLCK modulate the activation process of I CCh in murine ileal myocytes and suggest that the classical type transient receptor potential (TRPC) channel 5 might be a candidate for nonselective cationic currents (NSCC) activated by muscarinic stimulation in gastrointestinal smooth muscle cells.	Carbachol	67-70	calmodulin 2	Mus musculus	17-20
18066127-8	2007	We conclude that CaM and MLCK modulate the activation process of I CCh in murine ileal myocytes and suggest that the classical type transient receptor potential (TRPC) channel 5 might be a candidate for nonselective cationic currents (NSCC) activated by muscarinic stimulation in gastrointestinal smooth muscle cells.	Carbachol	67-70	myosin light chain kinase 3	Mus musculus	25-29
17394068-4	2007	In the perfused esophagus, addition of carbachol increased mucin secretion by approximately 2-fold.	Carbachol	39-48	LOC100508689	Homo sapiens	59-64
17920045-4	2007	Carbachol injected into the IGL of hamsters in their subjective day (CT8) induced phase advances similar to shifts that are induced by arousal at the same circadian time.	Carbachol	0-9	leucine zipper protein 4	Homo sapiens	69-72
17707768-3	2007	Zymography of N18TG2 culture medium revealed no gelatinolytic activity, whereas after carbachol treatment of cells both MMP-9 and activated MMP-2 forms were detected.	Carbachol	86-95	matrix metallopeptidase 9	Mus musculus	120-125
17707768-3	2007	Zymography of N18TG2 culture medium revealed no gelatinolytic activity, whereas after carbachol treatment of cells both MMP-9 and activated MMP-2 forms were detected.	Carbachol	86-95	matrix metallopeptidase 2	Mus musculus	140-145
17707768-5	2007	Carbachol treatment increased MMP-2 and MMP-9 gene expression in N18TG2 cells and higher levels for both genes were also observed in ChAT transfected cells.	Carbachol	0-9	matrix metallopeptidase 2	Mus musculus	30-35
17707768-5	2007	Carbachol treatment increased MMP-2 and MMP-9 gene expression in N18TG2 cells and higher levels for both genes were also observed in ChAT transfected cells.	Carbachol	0-9	matrix metallopeptidase 9	Mus musculus	40-45
17644755-3	2007	The isometric tension of tracheal rings from CAT-2-/- mice showed a significant decrease in carbachol (CCh)-induced force generation (33.01%, P &lt; 0.05, n = 8) compared with controls.	Carbachol	92-101	dominant cataract 2	Mus musculus	45-50
17964734-4	2007	In region CA1 of the rat (Sprague Dawley) hippocampus, the cholinergic agonist carbachol (CCh) suppresses transmission in stratum radiatum (SR), at synapses of the Schaffer collateral projection from CA3, while having lesser effects in stratum lacunosum-moleculare (SLM), the perforant path projection from entorhinal cortex (Hasselmo and Schnell, 1994).	Carbachol	79-88	carbonic anhydrase 1	Rattus norvegicus	10-13
17964734-4	2007	In region CA1 of the rat (Sprague Dawley) hippocampus, the cholinergic agonist carbachol (CCh) suppresses transmission in stratum radiatum (SR), at synapses of the Schaffer collateral projection from CA3, while having lesser effects in stratum lacunosum-moleculare (SLM), the perforant path projection from entorhinal cortex (Hasselmo and Schnell, 1994).	Carbachol	79-88	carbonic anhydrase 3	Rattus norvegicus	200-203
17964734-4	2007	In region CA1 of the rat (Sprague Dawley) hippocampus, the cholinergic agonist carbachol (CCh) suppresses transmission in stratum radiatum (SR), at synapses of the Schaffer collateral projection from CA3, while having lesser effects in stratum lacunosum-moleculare (SLM), the perforant path projection from entorhinal cortex (Hasselmo and Schnell, 1994).	Carbachol	90-93	carbonic anhydrase 1	Rattus norvegicus	10-13
17964734-4	2007	In region CA1 of the rat (Sprague Dawley) hippocampus, the cholinergic agonist carbachol (CCh) suppresses transmission in stratum radiatum (SR), at synapses of the Schaffer collateral projection from CA3, while having lesser effects in stratum lacunosum-moleculare (SLM), the perforant path projection from entorhinal cortex (Hasselmo and Schnell, 1994).	Carbachol	90-93	carbonic anhydrase 3	Rattus norvegicus	200-203
17644755-3	2007	The isometric tension of tracheal rings from CAT-2-/- mice showed a significant decrease in carbachol (CCh)-induced force generation (33.01%, P &lt; 0.05, n = 8) compared with controls.	Carbachol	103-106	dominant cataract 2	Mus musculus	45-50
17880368-7	2007	Contractile responses to muscarinic agonists (carbachol or AHR-602) and high K(+) were desensitized by pretreatment with 10(-6) mol/L carbachol for 30 min in a manner dependent on the presence of extracellular Ca(2+).	Carbachol	134-143	aryl hydrocarbon receptor	Cavia porcellus	59-62
17442131-8	2007	Immunohistochemistry for proliferating cell nuclear antigen (PCNA) showed that the 3-day Cch infusion significantly increased the number of PCNA-immunoreactive cells in the liver.	Carbachol	89-92	proliferating cell nuclear antigen	Rattus norvegicus	25-59
17984593-9	2007	The suppression of the carbachol-induced contraction was completely restored by COX inhibitor, indomethacin.	Carbachol	23-32	coproporphyrinogen oxidase	Rattus norvegicus	80-83
17320950-10	2007	PMA also reduced the Ca2+ response of intact RINm5F cells stimulated with carbachol and EGF, two agonists that use different receptor types to activate phospholipase C. These results suggest the existence of a negative feedback mechanism involving two components of the Ca2+ signalling cascade, whereby activated PKC dampens IP3R-3 activity.	Carbachol	74-83	protein kinase C, gamma	Rattus norvegicus	313-316
17320950-10	2007	PMA also reduced the Ca2+ response of intact RINm5F cells stimulated with carbachol and EGF, two agonists that use different receptor types to activate phospholipase C. These results suggest the existence of a negative feedback mechanism involving two components of the Ca2+ signalling cascade, whereby activated PKC dampens IP3R-3 activity.	Carbachol	74-83	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	325-331
17560078-6	2007	The increased efficacy of iG(q)alpha compared to mG(q)alpha was also seen downstream of PLC with carbachol stimulation of the mitogen-activated protein kinase, ERK1/2.	Carbachol	97-106	heparan sulfate proteoglycan 2	Homo sapiens	88-91
17560078-6	2007	The increased efficacy of iG(q)alpha compared to mG(q)alpha was also seen downstream of PLC with carbachol stimulation of the mitogen-activated protein kinase, ERK1/2.	Carbachol	97-106	mitogen-activated protein kinase 3	Homo sapiens	160-166
17928641-6	2007	pY-ERK level was strongly elevated by 10 nM CCK-8, 100 microM carbachol (CAR), or 100 nM EGF.	Carbachol	62-71	mitogen-activated protein kinase 1	Homo sapiens	3-6
17928641-6	2007	pY-ERK level was strongly elevated by 10 nM CCK-8, 100 microM carbachol (CAR), or 100 nM EGF.	Carbachol	73-76	mitogen-activated protein kinase 1	Homo sapiens	3-6
17688889-7	2007	Endothelin-1 and norepinephrine also increased the CCh (10 microM)-induced [Ca2+]i elevation.	Carbachol	51-54	endothelin 1	Homo sapiens	0-12
17803048-0	2007	Carbamoylcholine chloride induces a rapid increase in IL6 in the nasal cavity of C57BL/6 mice.	Carbachol	0-25	interleukin 6	Mus musculus	54-57
17803048-2	2007	In our work to determine the basal levels of cytokines in saliva, nasal wash fluid (NWF), bronchoalveolar lavage fluid (BALF), and serum of mice, we found that injection of carbamoylcholine chloride, used to stimulate saliva production, induced variations in the interleukin (IL) 6 levels of NWF and BALF supernatants.	Carbachol	173-198	interleukin 6	Mus musculus	263-281
17803048-5	2007	To determine whether carbamoylcholine chloride increased Th1 cytokine (IL2, IL12[p70], and interferon gamma), Th2 cytokine (IL4, IL5, and IL10), granulocyte-macrophage colony-stimulating factor (GM-CSF), or proinflammatory cytokine (IL1beta, tumor necrosis factor alpha, and IL6 in saliva and serum) levels, mice were given 10 microg carbamoylcholine chloride and euthanized.	Carbachol	21-46	negative elongation factor complex member C/D, Th1l	Mus musculus	57-60
17803048-5	2007	To determine whether carbamoylcholine chloride increased Th1 cytokine (IL2, IL12[p70], and interferon gamma), Th2 cytokine (IL4, IL5, and IL10), granulocyte-macrophage colony-stimulating factor (GM-CSF), or proinflammatory cytokine (IL1beta, tumor necrosis factor alpha, and IL6 in saliva and serum) levels, mice were given 10 microg carbamoylcholine chloride and euthanized.	Carbachol	21-46	interleukin 2	Mus musculus	71-74
17803048-5	2007	To determine whether carbamoylcholine chloride increased Th1 cytokine (IL2, IL12[p70], and interferon gamma), Th2 cytokine (IL4, IL5, and IL10), granulocyte-macrophage colony-stimulating factor (GM-CSF), or proinflammatory cytokine (IL1beta, tumor necrosis factor alpha, and IL6 in saliva and serum) levels, mice were given 10 microg carbamoylcholine chloride and euthanized.	Carbachol	21-46	interferon gamma	Mus musculus	91-107
17803048-5	2007	To determine whether carbamoylcholine chloride increased Th1 cytokine (IL2, IL12[p70], and interferon gamma), Th2 cytokine (IL4, IL5, and IL10), granulocyte-macrophage colony-stimulating factor (GM-CSF), or proinflammatory cytokine (IL1beta, tumor necrosis factor alpha, and IL6 in saliva and serum) levels, mice were given 10 microg carbamoylcholine chloride and euthanized.	Carbachol	21-46	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	195-201
17803048-5	2007	To determine whether carbamoylcholine chloride increased Th1 cytokine (IL2, IL12[p70], and interferon gamma), Th2 cytokine (IL4, IL5, and IL10), granulocyte-macrophage colony-stimulating factor (GM-CSF), or proinflammatory cytokine (IL1beta, tumor necrosis factor alpha, and IL6 in saliva and serum) levels, mice were given 10 microg carbamoylcholine chloride and euthanized.	Carbachol	21-46	interleukin 1 beta	Mus musculus	233-240
17803048-5	2007	To determine whether carbamoylcholine chloride increased Th1 cytokine (IL2, IL12[p70], and interferon gamma), Th2 cytokine (IL4, IL5, and IL10), granulocyte-macrophage colony-stimulating factor (GM-CSF), or proinflammatory cytokine (IL1beta, tumor necrosis factor alpha, and IL6 in saliva and serum) levels, mice were given 10 microg carbamoylcholine chloride and euthanized.	Carbachol	21-46	tumor necrosis factor	Mus musculus	242-269
17803048-5	2007	To determine whether carbamoylcholine chloride increased Th1 cytokine (IL2, IL12[p70], and interferon gamma), Th2 cytokine (IL4, IL5, and IL10), granulocyte-macrophage colony-stimulating factor (GM-CSF), or proinflammatory cytokine (IL1beta, tumor necrosis factor alpha, and IL6 in saliva and serum) levels, mice were given 10 microg carbamoylcholine chloride and euthanized.	Carbachol	21-46	interleukin 6	Mus musculus	275-278
17803048-7	2007	In summary, carbamoylcholine chloride induces a rapid, elevated IL6 response in the nasal cavity and respiratory tract of mice but does not alter the levels of other Th1, Th2, or proinflammatory cytokines.	Carbachol	12-37	interleukin 6	Mus musculus	64-67
17652747-8	2007	Parasympathomimetic stimulation by carbachol stimulated NHE and AE through the elevation of intracellular calcium concentration.	Carbachol	35-44	solute carrier family 9 member C1	Homo sapiens	56-59
17675796-6	2007	Furthermore, the AChR agonists nicotine and carbachol did not affect the neurite outgrowth induced by NGF.	Carbachol	44-53	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	17-21
17395899-11	2007	Incubation of colon tissue with carbamylcholine or deoxycholate to stimulate exocytosis by goblet cells caused a partial redistribution of Rab3D to the cytoplasm and mucous granule field and a concomitant transformation of the Golgi architecture.	Carbachol	32-47	RAB3D, member RAS oncogene family	Rattus norvegicus	139-144
17611397-9	2007	NOS1 and NOS3 isoforms are expressed in MCF-7 cells and its activation by CARB triggers nitric oxide synthesis and vascular endothelial growth factor expression increasing blood vessels formation induced by mammary tumor cells in vivo.	Carbachol	74-78	nitric oxide synthase 1	Homo sapiens	0-4
17611397-9	2007	NOS1 and NOS3 isoforms are expressed in MCF-7 cells and its activation by CARB triggers nitric oxide synthesis and vascular endothelial growth factor expression increasing blood vessels formation induced by mammary tumor cells in vivo.	Carbachol	74-78	nitric oxide synthase 3	Homo sapiens	9-13
17611397-9	2007	NOS1 and NOS3 isoforms are expressed in MCF-7 cells and its activation by CARB triggers nitric oxide synthesis and vascular endothelial growth factor expression increasing blood vessels formation induced by mammary tumor cells in vivo.	Carbachol	74-78	vascular endothelial growth factor A	Homo sapiens	115-149
17644755-8	2007	The reduced airway smooth muscle (ASM) contractility to CCh seen in the CAT-2-/- tracheal rings was completely reversed by pretreating the rings with 100 muM spermine.	Carbachol	56-59	dominant cataract 2	Mus musculus	72-77
17643958-1	2007	We previously showed that stimulation of muscarinic acetylcholine receptors (mAChR) by carbachol (Cch) caused a time- and dose-dependent increase of mitogen-activated protein kinase/extracellular signal-regulated kinases (MAPK/ERK) phosphorylation in thyroid epithelial cells.	Carbachol	87-96	mitogen-activated protein kinase 1	Homo sapiens	227-230
17643958-1	2007	We previously showed that stimulation of muscarinic acetylcholine receptors (mAChR) by carbachol (Cch) caused a time- and dose-dependent increase of mitogen-activated protein kinase/extracellular signal-regulated kinases (MAPK/ERK) phosphorylation in thyroid epithelial cells.	Carbachol	98-101	mitogen-activated protein kinase 1	Homo sapiens	227-230
17643958-4	2007	Incorporation of Pyk2 antisense oligonucleotides in thyroid epithelial cells to down-regulated Pyk2 expression or pretreatment of cells with the Ca(2+)/calmodulin protein kinase II (CaM kinase II) inhibitor KN-62 significantly reduced Cch-induced MAPK/ERK phosphorylation.	Carbachol	235-238	protein tyrosine kinase 2 beta	Homo sapiens	17-21
17643958-5	2007	In addition, Cch-induced MAPK/ERK phosphorylation was partially inhibited by LY294002 and wortmannin, two selective inhibitors of phosphatidylinositol 3-kinase (PI3K), tyrphostin AG1478, a specific inhibitor of epidermal growth factor receptor (EGFR) kinase, and (-)-perillic acid, a post-translational inhibitor of small G-proteins isoprenylation.	Carbachol	13-16	mitogen-activated protein kinase 1	Homo sapiens	30-33
17643958-5	2007	In addition, Cch-induced MAPK/ERK phosphorylation was partially inhibited by LY294002 and wortmannin, two selective inhibitors of phosphatidylinositol 3-kinase (PI3K), tyrphostin AG1478, a specific inhibitor of epidermal growth factor receptor (EGFR) kinase, and (-)-perillic acid, a post-translational inhibitor of small G-proteins isoprenylation.	Carbachol	13-16	epidermal growth factor receptor	Homo sapiens	211-243
17643958-5	2007	In addition, Cch-induced MAPK/ERK phosphorylation was partially inhibited by LY294002 and wortmannin, two selective inhibitors of phosphatidylinositol 3-kinase (PI3K), tyrphostin AG1478, a specific inhibitor of epidermal growth factor receptor (EGFR) kinase, and (-)-perillic acid, a post-translational inhibitor of small G-proteins isoprenylation.	Carbachol	13-16	epidermal growth factor receptor	Homo sapiens	245-249
17669399-10	2007	Activation of ET-BR by IRL-1620 (5 x 10(-7)M) results in contraction of native BTM (41% of the carbachol value) and also in a transient increase in [Ca(2+)](i) in cultured BTM and HTM cells (365 and 273% of the basal level, respectively).	Carbachol	95-104	endothelin receptor type B	Bos taurus	14-19
17923193-9	2007	RESULTS: The peak levels of force development induced by carbachol were 139.1% +/- 5.0% in EDNRB(-/-) rat, whereas the peak levels were 242.1% +/- 27.7% in EDNRB(+/+) rat.	Carbachol	57-66	endothelin receptor type B	Rattus norvegicus	91-96
17603544-4	2007	KEY RESULTS: Cationic currents elicited by carbachol (CCh; 100 microM) in HEK293 cells overexpressing murine TRPC6 (I(TRPC6)) were dose-dependently inhibited by externally applied ML-9 (IC(50)=7.8 microM).	Carbachol	43-52	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	109-114
17603544-4	2007	KEY RESULTS: Cationic currents elicited by carbachol (CCh; 100 microM) in HEK293 cells overexpressing murine TRPC6 (I(TRPC6)) were dose-dependently inhibited by externally applied ML-9 (IC(50)=7.8 microM).	Carbachol	43-52	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	118-123
17603544-4	2007	KEY RESULTS: Cationic currents elicited by carbachol (CCh; 100 microM) in HEK293 cells overexpressing murine TRPC6 (I(TRPC6)) were dose-dependently inhibited by externally applied ML-9 (IC(50)=7.8 microM).	Carbachol	54-57	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	109-114
17603544-4	2007	KEY RESULTS: Cationic currents elicited by carbachol (CCh; 100 microM) in HEK293 cells overexpressing murine TRPC6 (I(TRPC6)) were dose-dependently inhibited by externally applied ML-9 (IC(50)=7.8 microM).	Carbachol	54-57	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	118-123
17569886-4	2007	In contrast, when CD34+ cells are cultured in EGM-2 supplemented with platelet-derived growth factor-BB (50 ng/mL), they give rise to SM-like cells characterized by spindle-shape morphology, expression of SM cell markers (alpha-SM actin, SM myosin heavy chain, calponin, caldesmon, SM alpha-22), and the ability to contract and relax in response to common pharmacological agents such as carbachol and atropine but rarely form capillary-like structures when placed in Matrigel.	Carbachol	387-396	CD34 molecule	Homo sapiens	18-22
17573185-9	2007	There was an increase in SNARE complex formation in islets stimulated with prolactin, 22 mM glucose, 40 mM K(+), 200 microM carbachol and 1 microM PMA.	Carbachol	124-133	prolactin	Rattus norvegicus	75-84
17373911-8	2007	The PKA-induced enhancement of IP(3)R-3 activity was also observed in intact RINm5F cells stimulated with carbachol and epidermal growth factor, two agonists that use different receptor types to activate phospholipase C. CONCLUSION: The results of the present study reveal a converging step where the cAMP and the Ca2+ signalling systems act co-operatively in endocrine cell responses to external stimuli.	Carbachol	106-115	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	4-7
17373911-8	2007	The PKA-induced enhancement of IP(3)R-3 activity was also observed in intact RINm5F cells stimulated with carbachol and epidermal growth factor, two agonists that use different receptor types to activate phospholipase C. CONCLUSION: The results of the present study reveal a converging step where the cAMP and the Ca2+ signalling systems act co-operatively in endocrine cell responses to external stimuli.	Carbachol	106-115	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	31-39
17591863-10	2007	Carbachol also activated p42/44 MAPK in a time-dependent manner.	Carbachol	0-9	cyclin dependent kinase 20	Homo sapiens	25-28
17591863-11	2007	Preincubation with U0126 abolished carbachol-induced p42/44 MAPK activation and cell proliferation.	Carbachol	35-44	cyclin dependent kinase 20	Homo sapiens	53-56
17395173-1	2007	Carbachol-induced detrusor contractions are mainly mediated via M3 receptor subtype and depend not only on Ca2+ release from the intracellular calcium stores but also on Ca2+ influx via L-type Ca2+ channels.	Carbachol	0-9	cholinergic receptor muscarinic 3	Homo sapiens	64-66
17395173-6	2007	Carbachol-induced release of intracellular Ca2+ in Chinese hamster ovary cells expressing muscarinic hM3 receptors was completely prevented by 100 microM 2-APB.	Carbachol	0-9	cholinergic receptor muscarinic 3	Homo sapiens	101-104
17395173-7	2007	The direct intracellular IP3 receptor antagonist xestospongin C (10 microM) reduced carbachol-stimulated intracellular Ca2+ to 41% of the control value.	Carbachol	84-93	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	25-37
17307332-4	2007	Similarly, PKC inhibition enhanced EGFR transactivation in human colonic epithelial T84 cells stimulated with carbachol, as well as in bombesin-stimulated Rat-1 fibroblasts stably transfected with the bombesin receptor.	Carbachol	110-119	protein kinase C, alpha	Rattus norvegicus	11-14
17307332-4	2007	Similarly, PKC inhibition enhanced EGFR transactivation in human colonic epithelial T84 cells stimulated with carbachol, as well as in bombesin-stimulated Rat-1 fibroblasts stably transfected with the bombesin receptor.	Carbachol	110-119	epidermal growth factor receptor	Homo sapiens	35-39
17442131-8	2007	Immunohistochemistry for proliferating cell nuclear antigen (PCNA) showed that the 3-day Cch infusion significantly increased the number of PCNA-immunoreactive cells in the liver.	Carbachol	89-92	proliferating cell nuclear antigen	Rattus norvegicus	61-65
17442131-8	2007	Immunohistochemistry for proliferating cell nuclear antigen (PCNA) showed that the 3-day Cch infusion significantly increased the number of PCNA-immunoreactive cells in the liver.	Carbachol	89-92	proliferating cell nuclear antigen	Rattus norvegicus	140-144
17442131-9	2007	Moreover, the sera from the Cch-infused rats increased the number of PCNA-immunoreactive hepatocytes in culture.	Carbachol	28-31	proliferating cell nuclear antigen	Rattus norvegicus	69-73
17442131-11	2007	When compared with the monoculture of hepatocytes, the coculture of those with hepatic NPCs resulted in enhanced PCNA immunoreactivity after a 4-day treatment with 3 mM Cch.	Carbachol	169-172	proliferating cell nuclear antigen	Rattus norvegicus	113-117
17637176-6	2007	The H1R level was also up-regulated by M3R activation (150% of control by treatment with carbachol for 24 h).	Carbachol	89-98	histamine receptor H1	Homo sapiens	4-7
17564632-8	2007	These results suggest that the suppression of carbachol-induced contraction in mice with colitis is attributable at least partially to the increased activity of myosin phosphatase following the downregulation of CPI-17.	Carbachol	46-55	protein phosphatase 1, regulatory inhibitor subunit 14A	Mus musculus	212-218
17383686-4	2007	As a measure of cell proliferation ((3)H)-thymidine incorporation in primary human lung fibroblasts and MRC-5 fibroblasts was increased by about 2 fold in presence of the muscarinic receptor agonist carbachol (10 microM) and this effect could be prevented by the MEK inhibitor PD 98059 (30 microM).	Carbachol	199-208	mitogen-activated protein kinase kinase 7	Homo sapiens	263-266
17383686-5	2007	Western blot analysis revealed a rapid (within 2 min) activation of p42/44 MAPK (ERK1, ERK2) following exposure to 10 microM carbachol or oxotremorine, effects blocked by tiotropium as well as atropine.	Carbachol	125-134	mitogen-activated protein kinase 1	Homo sapiens	68-79
17383686-5	2007	Western blot analysis revealed a rapid (within 2 min) activation of p42/44 MAPK (ERK1, ERK2) following exposure to 10 microM carbachol or oxotremorine, effects blocked by tiotropium as well as atropine.	Carbachol	125-134	mitogen-activated protein kinase 3	Homo sapiens	81-85
17383686-5	2007	Western blot analysis revealed a rapid (within 2 min) activation of p42/44 MAPK (ERK1, ERK2) following exposure to 10 microM carbachol or oxotremorine, effects blocked by tiotropium as well as atropine.	Carbachol	125-134	mitogen-activated protein kinase 1	Homo sapiens	87-91
17277016-12	2007	The severe carbachol-induced sinus bradycardia in Galpha(i2)G184S mice suggests a possible role for alterations of Galpha(i2) or RGS proteins in sick sinus syndrome and pathological AV block.	Carbachol	11-20	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	50-59
17203464-8	2007	Pretreatment with the cAMP generating agent"s forskolin and vasoactive intestinal peptide (VIP) enhanced carbachol (Cch)-induced and epidermal growth factor (EGF)-induced Ca(2+) responses in intact AR4-2J cells.	Carbachol	105-114	vasoactive intestinal peptide	Rattus norvegicus	91-94
17203464-8	2007	Pretreatment with the cAMP generating agent"s forskolin and vasoactive intestinal peptide (VIP) enhanced carbachol (Cch)-induced and epidermal growth factor (EGF)-induced Ca(2+) responses in intact AR4-2J cells.	Carbachol	116-119	vasoactive intestinal peptide	Rattus norvegicus	91-94
17463038-2	2007	In cells from M2 subtype-knockout (M2-KO) or M3-KO mice, carbachol (100 microM) evoked a muscarinic cationic current (mI(Cat)) as small as approximately 10% of mI(Cat) in wild-type (WT) cells.	Carbachol	57-66	catalase	Mus musculus	89-125
17277016-12	2007	The severe carbachol-induced sinus bradycardia in Galpha(i2)G184S mice suggests a possible role for alterations of Galpha(i2) or RGS proteins in sick sinus syndrome and pathological AV block.	Carbachol	11-20	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	115-124
17240116-7	2007	We found that either carbachol or EGF promoted a striking ERK-dependent phosphorylation of FAK at Ser-910, but these agonists caused only slight stimulation of FAK at Tyr-397 in T84 cells.	Carbachol	21-30	EPH receptor B2	Homo sapiens	58-61
17234888-6	2007	The activation of both cAMP-dependent pathways or the selective activation of Epac was found to enhance amylase secretion induced by physiological and supraphysiological concentrations of the muscarinic agonist carbachol.	Carbachol	211-220	Rap guanine nucleotide exchange factor 3	Homo sapiens	78-82
17234888-7	2007	Similarly, activation of both PKA or the specific activation of Epac enhanced carbachol-induced activation of trypsinogen and chymotrypsinogen.	Carbachol	78-87	Rap guanine nucleotide exchange factor 3	Homo sapiens	64-68
17240116-7	2007	We found that either carbachol or EGF promoted a striking ERK-dependent phosphorylation of FAK at Ser-910, but these agonists caused only slight stimulation of FAK at Tyr-397 in T84 cells.	Carbachol	21-30	protein tyrosine kinase 2	Homo sapiens	91-94
16956963-6	2007	The responses to carbachol (CCh: 10 muM) were also greater in Pmca1(+/-) (120-150%) than in WT bladders.	Carbachol	17-26	ATPase, Ca++ transporting, plasma membrane 1	Mus musculus	62-67
17384670-6	2007	These inhibitors also attenuated the carbachol induced increase in nNOS- and eNOS-mRNA levels.	Carbachol	37-46	nitric oxide synthase 1	Rattus norvegicus	67-71
17384670-7	2007	Inhibition of nNOS shifted the dose response curve of carbachol on contractility to the right, whereas inhibition of eNOS shifted it to the left.	Carbachol	54-63	nitric oxide synthase 1	Rattus norvegicus	14-18
17250650-2	2007	In this study, we report that agonists for G protein-coupled receptors (GPCRs), including endothelin, lysophosphatidic acid and carbachol, effectively promote the expression of SMC-specific proteins in the presence of transforming growth factor-beta (TGF-beta).	Carbachol	128-137	transforming growth factor beta 1	Homo sapiens	218-249
17250650-2	2007	In this study, we report that agonists for G protein-coupled receptors (GPCRs), including endothelin, lysophosphatidic acid and carbachol, effectively promote the expression of SMC-specific proteins in the presence of transforming growth factor-beta (TGF-beta).	Carbachol	128-137	transforming growth factor beta 1	Homo sapiens	251-259
17448648-1	2007	The role of endothelin, PAF and thromboxane A2 in airway hyperreactivity (AHR) to carbachol induced by ovalbumin sensitization and challenge in Balb/c mice was investigated.	Carbachol	82-91	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	103-112
17448648-2	2007	Ovalbumin sensitization and challenge induced significant AHR to carbachol in actively sensitized and challenged mice.	Carbachol	65-74	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-9
17448648-11	2007	), endothelin-1 (100 pmol, intranasally) or the ET(B) receptor agonist IRL-1620 (100 pmol, intranasally) showed a marked increase in airway reactivity to carbachol.	Carbachol	154-163	endothelin 1	Mus musculus	3-15
17306779-10	2007	In conclusion, results suggest that microinjection of CBH in the BST activates local M(2)-muscarinic receptor evoking pressor and bradycardiac responses, which are mediated by acute vasopressin release into circulation.	Carbachol	54-57	arginine vasopressin	Rattus norvegicus	182-193
17255165-2	2007	In this study, we investigated the mechanism of the receptor-mediated regulation of I(GIRK) in acutely isolated hippocampal CA1 neurons by the muscarinic receptor agonist, carbachol (CCh), and the group I metabotropic glutamate receptor (mGluR) agonist, 3,5-dihydroxyphenylglycine (DHPG).	Carbachol	172-181	carbonic anhydrase 1	Rattus norvegicus	124-127
17255165-2	2007	In this study, we investigated the mechanism of the receptor-mediated regulation of I(GIRK) in acutely isolated hippocampal CA1 neurons by the muscarinic receptor agonist, carbachol (CCh), and the group I metabotropic glutamate receptor (mGluR) agonist, 3,5-dihydroxyphenylglycine (DHPG).	Carbachol	183-186	carbonic anhydrase 1	Rattus norvegicus	124-127
17255165-6	2007	In PLCbeta1 knockout mice, the effect of CCh on I(GIRK) was significantly reduced, whereas the effect of DHPG remained unchanged.	Carbachol	41-44	phospholipase C, beta 1	Mus musculus	3-11
17428986-6	2007	Furthermore, we establish that carbachol affects the overall phosphorylation of ADAM17 on its threonine and tyrosine but not serine residues, whereas levels of phosphorylated ADAM9 were not affected.	Carbachol	31-40	ADAM metallopeptidase domain 17	Homo sapiens	80-86
17428986-8	2007	Mutations of threonine 735 but not of tyrosine 702 of the ADAM17 cytoplasmic tail abolishes the carbachol-induced increase of N1, ADAM17 phosphorylation, and JMV2770-hydrolyzing activity in M1- and M3-expressing HEK293 cells.	Carbachol	96-105	ADAM metallopeptidase domain 17	Homo sapiens	58-64
17428986-8	2007	Mutations of threonine 735 but not of tyrosine 702 of the ADAM17 cytoplasmic tail abolishes the carbachol-induced increase of N1, ADAM17 phosphorylation, and JMV2770-hydrolyzing activity in M1- and M3-expressing HEK293 cells.	Carbachol	96-105	ADAM metallopeptidase domain 17	Homo sapiens	130-136
17164431-6	2007	Cells secreted PRL consititutively and at increased rates in response to CCh.	Carbachol	73-76	prolactin	Oryctolagus cuniculus	15-18
17408632-0	2007	Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis.	Carbachol	68-77	syntaxin binding protein 3	Rattus norvegicus	57-64
17197450-6	2007	Stimulation with concentrations of glucose and carbachol that accelerate hydrolysis of endogenous AA from islet phosphoplipids also results in accelerated Kv2.1 inactivation and a shorter time-to-peak current interval.	Carbachol	47-56	potassium voltage-gated channel subfamily B member 1	Rattus norvegicus	155-160
17305705-13	2007	The residual CCH effect observed in K(Ca)3.1 KO mice suggests that yet another K+ channel is driving the CCH-stimulated Cl- secretion.	Carbachol	13-16	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	36-44
17305705-13	2007	The residual CCH effect observed in K(Ca)3.1 KO mice suggests that yet another K+ channel is driving the CCH-stimulated Cl- secretion.	Carbachol	105-108	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	36-44
17446468-9	2007	Studies of bladder smooth muscle from PMCA4 null mutants and PMCA1 heterozygous mice suggest that PMCA1 and PMCA4 play different roles in smooth muscle contractility, with PMCA1 contributing to overall Ca2+ clearance and PMCA4 being required for carbachol-stimulated contraction.	Carbachol	246-255	ATPase, Ca++ transporting, plasma membrane 1	Mus musculus	98-103
17446468-9	2007	Studies of bladder smooth muscle from PMCA4 null mutants and PMCA1 heterozygous mice suggest that PMCA1 and PMCA4 play different roles in smooth muscle contractility, with PMCA1 contributing to overall Ca2+ clearance and PMCA4 being required for carbachol-stimulated contraction.	Carbachol	246-255	ATPase, Ca++ transporting, plasma membrane 4	Mus musculus	108-113
17446468-9	2007	Studies of bladder smooth muscle from PMCA4 null mutants and PMCA1 heterozygous mice suggest that PMCA1 and PMCA4 play different roles in smooth muscle contractility, with PMCA1 contributing to overall Ca2+ clearance and PMCA4 being required for carbachol-stimulated contraction.	Carbachol	246-255	ATPase, Ca++ transporting, plasma membrane 1	Mus musculus	98-103
17446468-9	2007	Studies of bladder smooth muscle from PMCA4 null mutants and PMCA1 heterozygous mice suggest that PMCA1 and PMCA4 play different roles in smooth muscle contractility, with PMCA1 contributing to overall Ca2+ clearance and PMCA4 being required for carbachol-stimulated contraction.	Carbachol	246-255	ATPase, Ca++ transporting, plasma membrane 4	Mus musculus	108-113
17301171-5	2007	Surprisingly, marked gender differences in GHRH neuronal activity were observed in response to the muscarinic agonist carbachol (CCh).	Carbachol	118-127	growth hormone releasing hormone	Mus musculus	43-47
17301171-5	2007	Surprisingly, marked gender differences in GHRH neuronal activity were observed in response to the muscarinic agonist carbachol (CCh).	Carbachol	129-132	growth hormone releasing hormone	Mus musculus	43-47
17301171-6	2007	In females, CCh enhanced action potential firing in all GHRH neurons.	Carbachol	12-15	growth hormone releasing hormone	Mus musculus	56-60
17301171-7	2007	In males, CCh enhanced action potential firing in two-thirds of GHRH neurons, whereas it decreased firing in the remainders.	Carbachol	10-13	growth hormone releasing hormone	Mus musculus	64-68
17307724-9	2007	In beta-escin-permeabilized ileal tissues, pretreatment with anti-phosphorylated CPI-17 antibody inhibited the carbachol-induced Ca(2+) sensitization in the presence of GTP.	Carbachol	111-120	protein phosphatase 1, regulatory inhibitor subunit 14A	Mus musculus	81-87
17204498-8	2007	It is important to note that glands from CFTR knockout mice responded to carbachol but did not secrete when exposed to VIP or forskolin, as has been shown previously for glands from CF patients.	Carbachol	73-82	cystic fibrosis transmembrane conductance regulator	Mus musculus	41-45
17305705-12	2007	CCH-stimulated DeltaIsc was significantly reduced in K(Ca)3.1 KO mice, underscoring the known relevance of this channel in the activation of Cl- secretion by an intracellular Ca2+ increasing agonist.	Carbachol	0-3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	53-61
17095754-4	2007	Although blocking the presumably apically located K(+) channel KCNQ1 with chromanol 293b reduced both the forskolin- and carbachol-induced cell shrinkage, inhibition of Ca(2+)-sensitive K(+) channels with charybdotoxin strongly inhibited the cell volume decrease after carbachol, but not after forskolin stimulation.	Carbachol	121-130	potassium voltage-gated channel subfamily KQT member 1	Oryctolagus cuniculus	63-68
17095754-4	2007	Although blocking the presumably apically located K(+) channel KCNQ1 with chromanol 293b reduced both the forskolin- and carbachol-induced cell shrinkage, inhibition of Ca(2+)-sensitive K(+) channels with charybdotoxin strongly inhibited the cell volume decrease after carbachol, but not after forskolin stimulation.	Carbachol	269-278	potassium voltage-gated channel subfamily KQT member 1	Oryctolagus cuniculus	63-68
17213482-6	2007	Treatment with ANG-(1-7) or AVE-0991 also prevented the diabetes-induced abnormal vascular responsiveness to norepinephrine, endothelin-1, angiotensin II, carbachol, and histamine in the perfused mesenteric bed and isolated carotid and renal arteries.	Carbachol	155-164	angiopoietin 1	Homo sapiens	15-23
17310102-9	2007	PRL attenuated the increase in intracellular Ca(2+) that was caused by stimulation of isolated colonic crypts with carbachol.	Carbachol	115-124	prolactin	Mus musculus	0-3
16868751-3	2007	In comparison with the control animals, all Cftr (TgH(neoim)1Hgu) congenic mice had a distinctly reduced basal chloride secretion and a reduced chloride secretion after stimulation with carbachol and forskolin.	Carbachol	186-195	cystic fibrosis transmembrane conductance regulator	Mus musculus	44-48
17268693-8	2007	The response of the EBs to carbachol was more in the bFGF group than 7+14 days.	Carbachol	27-36	fibroblast growth factor 2	Mus musculus	53-57
16899552-1	2007	EGF inhibits carbachol-induced chloride secretion by regulating a basolateral potassium channel via phosphatidylinositol 3-kinase (PI 3-kinase) and PKCepsilon activation.	Carbachol	13-22	protein kinase C epsilon	Homo sapiens	148-158
16899552-2	2007	Although both EGF and carbachol cause tyrosine phosphorylation of p85 of PI 3-kinase, only EGF activates the enzyme.	Carbachol	22-31	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	66-69
16899552-4	2007	Our present study examined whether the differential effects of carbachol and EGF on PI 3-kinase activity correspond to varying phosphorylation of p85, and the mechanisms and consequences.	Carbachol	63-72	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	146-149
16899552-8	2007	Both tyrosine and serine residues of p85 were phosphorylated by carbachol, whereas EGF induced only tyrosine phosphorylation.	Carbachol	64-73	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	37-40
16899552-9	2007	Moreover, EGF abolished carbachol-induced serine phosphorylation of p85 and activated PP2A without affecting PP1.	Carbachol	24-33	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	68-71
16899552-9	2007	Moreover, EGF abolished carbachol-induced serine phosphorylation of p85 and activated PP2A without affecting PP1.	Carbachol	24-33	protein phosphatase 2 phosphatase activator	Homo sapiens	86-90
16899552-12	2007	Although carbachol recruits p85, it phosphorylates both serine and tyrosine residues so that the lipid kinase of PI 3-kinase is inhibited.	Carbachol	9-18	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	28-31
16868751-3	2007	In comparison with the control animals, all Cftr (TgH(neoim)1Hgu) congenic mice had a distinctly reduced basal chloride secretion and a reduced chloride secretion after stimulation with carbachol and forskolin.	Carbachol	186-195	carboxylesterase 1D	Mus musculus	50-53
16782699-4	2006	The relaxation response to (-)-isoprenaline in carbachol-contracted small intestinal tissue segments was reduced in caveolin-1 knockout mice (cav1(-/-)) compared with their genetic controls (cav1(+/+)).	Carbachol	47-56	caveolin 1, caveolae protein	Mus musculus	116-126
17005918-8	2007	In separate groups of ApoE-/- mice, NCX 6550 significantly enhanced endothelium-dependent relaxation to carbachol in aortic segments precon-tracted with phenylephrine (-logEC(50), 6.37 +/- 0.37) compared with both vehicle-treated (-logEC50, 5.81 +/- 0.15; P &lt; 0.001) and pravastatin-treated (-logEC50, 5.57 +/- 0.45; P &lt; 0.05) mice.	Carbachol	104-113	T cell leukemia, homeobox 2	Mus musculus	36-39
17026971-5	2006	Carbachol stimulation of SH-SY5Y cells dose-dependently stimulated the activation of the transcription factors NFkappaB and AP-1 as revealed by electrophoretic mobility shift assay (EMSA), while pre-exposure of SH-SY5Y cells for 24 h with 1 ng/ml IL-1beta completely suppressed the carbachol response.	Carbachol	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	124-128
17026971-5	2006	Carbachol stimulation of SH-SY5Y cells dose-dependently stimulated the activation of the transcription factors NFkappaB and AP-1 as revealed by electrophoretic mobility shift assay (EMSA), while pre-exposure of SH-SY5Y cells for 24 h with 1 ng/ml IL-1beta completely suppressed the carbachol response.	Carbachol	0-9	interleukin 1 alpha	Homo sapiens	247-255
17026971-5	2006	Carbachol stimulation of SH-SY5Y cells dose-dependently stimulated the activation of the transcription factors NFkappaB and AP-1 as revealed by electrophoretic mobility shift assay (EMSA), while pre-exposure of SH-SY5Y cells for 24 h with 1 ng/ml IL-1beta completely suppressed the carbachol response.	Carbachol	282-291	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	124-128
17026971-6	2006	mAChR-mediated enhancements of AChE activity by carbachol were impaired following pre-exposure of SH-SY5Y cells with IL-1beta, already detectable at a concentration of 1 ng/ml and 1 h of exposure time.	Carbachol	48-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	31-35
17026971-6	2006	mAChR-mediated enhancements of AChE activity by carbachol were impaired following pre-exposure of SH-SY5Y cells with IL-1beta, already detectable at a concentration of 1 ng/ml and 1 h of exposure time.	Carbachol	48-57	interleukin 1 alpha	Homo sapiens	117-125
16838106-4	2007	TRPC7-transfected HEK293 cells showed an augmentation of carbachol-induced intracellular Ca2+ transient, which was attenuated under a Ca2+-free condition or in the presence of SK&amp;F96365 (a Ca2+-permeable channel blocker).	Carbachol	57-66	transient receptor potential cation channel subfamily C member 7	Homo sapiens	0-5
16838106-4	2007	TRPC7-transfected HEK293 cells showed an augmentation of carbachol-induced intracellular Ca2+ transient, which was attenuated under a Ca2+-free condition or in the presence of SK&amp;F96365 (a Ca2+-permeable channel blocker).	Carbachol	57-66	carbonic anhydrase 2	Homo sapiens	89-92
16838106-4	2007	TRPC7-transfected HEK293 cells showed an augmentation of carbachol-induced intracellular Ca2+ transient, which was attenuated under a Ca2+-free condition or in the presence of SK&amp;F96365 (a Ca2+-permeable channel blocker).	Carbachol	57-66	carbonic anhydrase 2	Homo sapiens	134-137
16838106-4	2007	TRPC7-transfected HEK293 cells showed an augmentation of carbachol-induced intracellular Ca2+ transient, which was attenuated under a Ca2+-free condition or in the presence of SK&amp;F96365 (a Ca2+-permeable channel blocker).	Carbachol	57-66	carbonic anhydrase 2	Homo sapiens	134-137
16925472-5	2007	Immunohistochemistry showed that carbachol induced an increase of neuronal nitric oxide synthase immunoreactivity (nNOS-IR) in the LC and renal proximal tubular cells.	Carbachol	33-42	nitric oxide synthase 1	Homo sapiens	66-96
16925472-5	2007	Immunohistochemistry showed that carbachol induced an increase of neuronal nitric oxide synthase immunoreactivity (nNOS-IR) in the LC and renal proximal tubular cells.	Carbachol	33-42	nitric oxide synthase 1	Homo sapiens	115-119
16925472-7	2007	The same was true for carbachol-induced increase of nNOS-IR in the LC and PCT.	Carbachol	22-31	nitric oxide synthase 1	Homo sapiens	52-56
17035232-5	2006	CCK-8, carbachol, and bombesin, but not VIP/secretin, decreased c-Met.	Carbachol	7-16	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	64-69
17065500-3	2006	The effects of PGF(2)alpha and CCh on the phosphorylation of myosin light chain (MLC) were also analyzed.	Carbachol	31-34	myosin light chain 1	Sus scrofa	81-84
16782699-4	2006	The relaxation response to (-)-isoprenaline in carbachol-contracted small intestinal tissue segments was reduced in caveolin-1 knockout mice (cav1(-/-)) compared with their genetic controls (cav1(+/+)).	Carbachol	47-56	caveolin 1, caveolae protein	Mus musculus	142-146
17092423-8	2006	While in carbachol treatment group, the number of splenic DC had no significant change, the expression of IL-1 beta was down-regulated, dramatically.	Carbachol	9-18	interleukin 1 beta	Mus musculus	106-115
16675744-9	2006	We conclude that NBC in the murine colon is thus activated by carbachol, consistent with its presumed function as an anion uptake pathway during intestinal anion secretion, but that the signal transductions pathways are distinct from those involved in the cholinergic activation of renal NBC1.	Carbachol	62-71	solute carrier family 4 (anion exchanger), member 4	Mus musculus	17-20
16675744-9	2006	We conclude that NBC in the murine colon is thus activated by carbachol, consistent with its presumed function as an anion uptake pathway during intestinal anion secretion, but that the signal transductions pathways are distinct from those involved in the cholinergic activation of renal NBC1.	Carbachol	62-71	solute carrier family 4 (anion exchanger), member 4	Mus musculus	288-292
17005856-3	2006	To better understand the synaptic mechanisms involved in gamma oscillogenesis, we recorded action potentials and synaptic currents in distinct types of anatomically identified CA3 neurons during carbachol-induced (20-25 microM) gamma oscillations in rat hippocampal slices.	Carbachol	195-204	carbonic anhydrase 3	Rattus norvegicus	176-179
16741513-9	2006	Finally, transient receptor potential canonical 7 (TRPC7) specific knockdown by antisense oligonucleotides led to a decrease in ATP- and CCh-induced calcium entry, as well as OAG-evoked current.	Carbachol	137-140	transient receptor potential cation channel subfamily C member 7	Homo sapiens	9-49
16809362-10	2006	Synaptically activating waves in the presence of low concentrations of carbachol, which probably increased the tonic level of IP3 throughout the cell, enhanced the extent of propagation and generated waves that invaded the soma, as long as low-affinity indicators were used to detect the [Ca2+]i changes.	Carbachol	71-80	carbonic anhydrase 2	Rattus norvegicus	289-292
17033098-12	2006	The carbachol-induced corticosterone response was significantly increased by pretreatment with nNOS inhibitor L-NNA and was considerably reduced by indomethacin, a general COX inhibitor.	Carbachol	4-13	nitric oxide synthase 1	Rattus norvegicus	95-99
16806302-5	2006	Extracellular recordings from CA1 and CA3 regions suggest that carbachol-mediated population activity was regionalized in our preparations.	Carbachol	63-72	carbonic anhydrase 1	Mus musculus	30-33
16806302-5	2006	Extracellular recordings from CA1 and CA3 regions suggest that carbachol-mediated population activity was regionalized in our preparations.	Carbachol	63-72	carbonic anhydrase 3	Mus musculus	38-41
16951552-0	2006	Involvement of the phospholipase C beta1 pathway in desensitization of the carbachol-activated nonselective cationic current in murine gastric myocytes.	Carbachol	75-84	phospholipase C, beta 1	Mus musculus	19-40
16938132-7	2006	Using rat tracheal rings, we observed that the activation of CFTR by benzoquinolizinium derivatives in TSMC leads to CFTRinh-172-sensitive bronchodilation after constriction with carbachol.	Carbachol	179-188	CF transmembrane conductance regulator	Rattus norvegicus	61-65
16741513-9	2006	Finally, transient receptor potential canonical 7 (TRPC7) specific knockdown by antisense oligonucleotides led to a decrease in ATP- and CCh-induced calcium entry, as well as OAG-evoked current.	Carbachol	137-140	transient receptor potential cation channel subfamily C member 7	Homo sapiens	51-56
16865060-9	2006	RESULTS: The results of this study suggest that blockade of chemokine receptors significantly potentiated erythropoietin- and quercetin-induced inhibition of carbachol-induced bronchoconstriction (P&lt;0.05) compared with the control group.	Carbachol	158-167	erythropoietin	Mus musculus	106-120
16765919-8	2006	Activation of TRPC1 protein by either thapsigargin or carbachol further protected SH-SY5Y cells from salsolinol treatments.	Carbachol	54-63	transient receptor potential cation channel subfamily C member 1	Homo sapiens	14-19
16185843-4	2006	HGF and EGF stimulated total Gab1 tyrosine phosphorylation (TyrP) and TyrP of Gab1 phospho-specific sites (Y307, Y627), but not other pancreatic growth factors, GI GPCRs (CCK, bombesin, carbachol, VIP, secretin), or agents directly activating PKC or increasing Ca2+.	Carbachol	186-195	hepatocyte growth factor	Rattus norvegicus	0-3
16877402-7	2006	Inhibition of PKC partially inhibited carbachol-stimulated MAPK activation while completely inhibiting phenylephrine- and EGF-stimulated MAPK activation.	Carbachol	38-47	mitogen activated protein kinase 3	Rattus norvegicus	59-63
16877402-8	2006	Chelation of Ca(2+) also partially inhibited carbachol-stimulated MAPK with no effect on phenylephrine- and EGF-stimulated MAPK activation.	Carbachol	45-54	mitogen activated protein kinase 3	Rattus norvegicus	66-70
16877402-9	2006	Carbachol increased the phosphorylation of Pyk2 on tyrosine 402 and c-src on tyrosine 416 in a time-dependent manner.	Carbachol	0-9	protein tyrosine kinase 2 beta	Rattus norvegicus	43-47
16877402-9	2006	Carbachol increased the phosphorylation of Pyk2 on tyrosine 402 and c-src on tyrosine 416 in a time-dependent manner.	Carbachol	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	68-73
16877402-10	2006	The c-src inhibitor PP1 inhibited carbachol-stimulated phosphorylation of Pyk2.	Carbachol	34-43	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	4-9
16877402-10	2006	The c-src inhibitor PP1 inhibited carbachol-stimulated phosphorylation of Pyk2.	Carbachol	34-43	neuropeptide Y receptor Y4	Rattus norvegicus	20-23
16877402-10	2006	The c-src inhibitor PP1 inhibited carbachol-stimulated phosphorylation of Pyk2.	Carbachol	34-43	protein tyrosine kinase 2 beta	Rattus norvegicus	74-78
16467403-5	2006	In a test of the specific hypothesis that the level of APP intracellular domain (AICD), the intracellular fragment of the beta-amyloid precursor protein (APP) resulting from gamma-secretase cleavage, can modulate the Ca(2+) content of the endoplasmic reticulum, we were unable to demonstrate any effect of APP small interfering RNA on the magnitude of carbachol-induced intracellular calcium release in HSG cells.	Carbachol	352-361	amyloid beta precursor protein	Homo sapiens	122-152
16879495-4	2006	Carbachol stimulates DNA synthesis, InsP and the expression of CD40.	Carbachol	0-9	CD40 molecule	Homo sapiens	63-67
16879498-10	2006	Tissue incubation with TNF-alpha (100 ng ml(-1))/IL-1beta (10 ng ml(-1)) increased in vitro tracheal responsiveness to carbachol.	Carbachol	119-128	tumor necrosis factor	Rattus norvegicus	23-32
16879498-10	2006	Tissue incubation with TNF-alpha (100 ng ml(-1))/IL-1beta (10 ng ml(-1)) increased in vitro tracheal responsiveness to carbachol.	Carbachol	119-128	interleukin 1 beta	Rattus norvegicus	49-57
16185843-4	2006	HGF and EGF stimulated total Gab1 tyrosine phosphorylation (TyrP) and TyrP of Gab1 phospho-specific sites (Y307, Y627), but not other pancreatic growth factors, GI GPCRs (CCK, bombesin, carbachol, VIP, secretin), or agents directly activating PKC or increasing Ca2+.	Carbachol	186-195	GRB2-associated binding protein 1	Rattus norvegicus	29-33
16756988-5	2006	Importantly, RGS2 selectively inhibited Gq/11 signaling, whereas RGS3, RGS4 and RGS5 had the capacity to regulate both Gq/11 and Gi/o signaling (carbachol-induced cAMP inhibition).	Carbachol	145-154	regulator of G protein signaling 2	Homo sapiens	13-17
16756988-5	2006	Importantly, RGS2 selectively inhibited Gq/11 signaling, whereas RGS3, RGS4 and RGS5 had the capacity to regulate both Gq/11 and Gi/o signaling (carbachol-induced cAMP inhibition).	Carbachol	145-154	regulator of G protein signaling 3	Homo sapiens	65-69
16756988-5	2006	Importantly, RGS2 selectively inhibited Gq/11 signaling, whereas RGS3, RGS4 and RGS5 had the capacity to regulate both Gq/11 and Gi/o signaling (carbachol-induced cAMP inhibition).	Carbachol	145-154	regulator of G protein signaling 4	Homo sapiens	71-75
16756988-5	2006	Importantly, RGS2 selectively inhibited Gq/11 signaling, whereas RGS3, RGS4 and RGS5 had the capacity to regulate both Gq/11 and Gi/o signaling (carbachol-induced cAMP inhibition).	Carbachol	145-154	regulator of G protein signaling 5	Homo sapiens	80-84
16631594-2	2006	Using Chinese hamster ovary (CHO) cells stably expressing GAR-3b, the major alternatively spliced isoform of GAR-3, we observed that carbachol stimulated cyclic AMP (cAMP) production in a dose- and time-dependent manner.	Carbachol	133-142	Muscarinic acetylcholine receptor gar-3	Caenorhabditis elegans	58-63
16773404-10	2006	Carbachol and ATP, which both induce a Ca(2+) release from internal Ca(2+) stores, also increased the NHE3 activity.	Carbachol	0-9	solute carrier family 9 member A3	Sus scrofa	102-106
16741047-7	2006	Serum withdrawal from the incubation medium as well as addition of carbachol or PMA for 24 hrs also led to a significant reduction of the levels of ECE-1 protein in NB7 cells.	Carbachol	67-76	endothelin converting enzyme 1	Homo sapiens	148-153
16620785-8	2006	Stimulation of muscarinic receptors with carbachol in SH-SY5Y cells also activated AMPK and transiently caused dephosphorylation of Akt.	Carbachol	41-50	AKT serine/threonine kinase 1	Homo sapiens	132-135
16794864-4	2006	When Chinese hamster ovary cells stably expressing GAR-3 were treated with carbachol, GAR-3 was internalized in a dose- and time-dependent manner.	Carbachol	75-84	Muscarinic acetylcholine receptor gar-3	Caenorhabditis elegans	51-56
16794864-4	2006	When Chinese hamster ovary cells stably expressing GAR-3 were treated with carbachol, GAR-3 was internalized in a dose- and time-dependent manner.	Carbachol	75-84	Muscarinic acetylcholine receptor gar-3	Caenorhabditis elegans	86-91
16794864-5	2006	Approximately 60% of the cell surface receptor was internalized by exposure to 1 mM carbachol for 1 h. Carbachol-induced GAR-3 internalization was suppressed by treatment with hypertonic sucrose, which blocks the formation of clathrin-coated pits.	Carbachol	84-93	Muscarinic acetylcholine receptor gar-3	Caenorhabditis elegans	121-126
16794864-5	2006	Approximately 60% of the cell surface receptor was internalized by exposure to 1 mM carbachol for 1 h. Carbachol-induced GAR-3 internalization was suppressed by treatment with hypertonic sucrose, which blocks the formation of clathrin-coated pits.	Carbachol	103-112	Muscarinic acetylcholine receptor gar-3	Caenorhabditis elegans	121-126
16794864-6	2006	Overexpression of a dominant-negative dynamin mutant (DynK44A), but not of a dominant-negative beta-arrestin mutant (Arr319-418), substantially inhibited carbachol-induced internalization of GAR-3.	Carbachol	154-163	Muscarinic acetylcholine receptor gar-3	Caenorhabditis elegans	191-196
16520739-3	2006	Stimulation of PAR-2 by trypsin-induced relaxation of carbachol- and KCl-induced contractions in normal rat colonic smooth muscle was completely resolved by tissue pretreatment with apamin, but not by pretreatment with l-NMMA or a cocktail of neuronal blockers (tetrodotoxin, hexamethonium and propranolol).	Carbachol	54-63	F2R like trypsin receptor 1	Rattus norvegicus	15-20
16393138-3	2006	In the present study, we used subsarcolemmal- and mitochondrial-targeted aequorin to study the effect of the antiapoptotic Bcl-2 protein overexpression on carbachol-induced near-plasma membrane and mitochondrial calcium responses in myotubes derived from control C57 and dystrophic (mdx) mice.	Carbachol	155-164	B cell leukemia/lymphoma 2	Mus musculus	123-128
16510245-6	2006	Microinjections of carbachol into the LSV and corticotropin-releasing factor into the MeA, and intracerebroventricular injection of hypertonic saline, activated AHA angiotensin II-sensitive neurons.	Carbachol	19-28	angiotensinogen	Rattus norvegicus	165-179
16213169-8	2006	Also, hM1 receptors elicited phosphoinositide hydrolysis to carbachol once expressed at the plasma membrane and the pharmacology of the response varied depending upon the concentration of AP21998 used to cause plasma membrane expression.	Carbachol	60-69	cholinergic receptor muscarinic 1	Homo sapiens	6-9
16306123-3	2006	TRPC5 was initially activated by muscarinic stimulation with 50 microM carbachol and then decayed rapidly even in the presence of carbachol.	Carbachol	71-80	transient receptor potential cation channel subfamily C member 5	Homo sapiens	0-5
16306123-3	2006	TRPC5 was initially activated by muscarinic stimulation with 50 microM carbachol and then decayed rapidly even in the presence of carbachol.	Carbachol	130-139	transient receptor potential cation channel subfamily C member 5	Homo sapiens	0-5
16339998-2	2006	Carbachol (1 microM) induced significant increases in the expression of cyclooxygenase (COX)-1, COX-2, IL-8, and plasminogen activator, urokinase type (PLAU) to levels ranging from 1.3- to 3.1-fold of control.	Carbachol	0-9	cytochrome c oxidase subunit I	Bos taurus	72-94
16339998-2	2006	Carbachol (1 microM) induced significant increases in the expression of cyclooxygenase (COX)-1, COX-2, IL-8, and plasminogen activator, urokinase type (PLAU) to levels ranging from 1.3- to 3.1-fold of control.	Carbachol	0-9	cytochrome c oxidase subunit II	Bos taurus	96-101
16339998-2	2006	Carbachol (1 microM) induced significant increases in the expression of cyclooxygenase (COX)-1, COX-2, IL-8, and plasminogen activator, urokinase type (PLAU) to levels ranging from 1.3- to 3.1-fold of control.	Carbachol	0-9	C-X-C motif chemokine ligand 8	Bos taurus	103-107
16339998-2	2006	Carbachol (1 microM) induced significant increases in the expression of cyclooxygenase (COX)-1, COX-2, IL-8, and plasminogen activator, urokinase type (PLAU) to levels ranging from 1.3- to 3.1-fold of control.	Carbachol	0-9	plasminogen activator, urokinase	Bos taurus	152-156
16469785-4	2006	Mutant NCS-1 does not inhibit surface-expression of TRPC5 but generally suppresses channel activity, irrespective of whether it is evoked by carbachol, store depletion, lanthanides or elevated intracellular calcium.	Carbachol	141-150	neuronal calcium sensor 1	Rattus norvegicus	7-12
16227319-6	2006	In both nontransformed human cultured airway smooth muscle cells and cells transduced with wild-type human Lyn kinase, carbachol increased Lyn kinase activity.	Carbachol	119-128	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
16227319-6	2006	In both nontransformed human cultured airway smooth muscle cells and cells transduced with wild-type human Lyn kinase, carbachol increased Lyn kinase activity.	Carbachol	119-128	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	139-142
16227319-7	2006	Pertussis toxin pretreatment failed to block carbachol activation of Lyn kinase but did attenuate the carbachol-induced increase in ERK/MAPK phosphorylation.	Carbachol	102-111	EPH receptor B2	Homo sapiens	132-135
16565731-0	2006	Involvement of Rho kinase and protein kinase C in carbachol-induced calcium sensitization in beta-escin skinned rat and guinea-pig bladders.	Carbachol	50-59	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	15-25
16565731-12	2006	The Rho kinase (ROK) inhibitor Y-27632 (5 microM) added in the presence of CCh reversed the calcium sensitization in rat bladder, whereas a transient contraction followed by a relaxation to a level not significantly different from the CCh contraction was seen in both guinea-pig bladder and taenia caecum.	Carbachol	75-78	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	4-14
16565731-12	2006	The Rho kinase (ROK) inhibitor Y-27632 (5 microM) added in the presence of CCh reversed the calcium sensitization in rat bladder, whereas a transient contraction followed by a relaxation to a level not significantly different from the CCh contraction was seen in both guinea-pig bladder and taenia caecum.	Carbachol	75-78	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	16-19
16439036-2	2006	Here we present evidence that incubation of oligodendrocyte progenitors, deprived of growth factor, with the acetylcholine analog carbachol significantly reduced cell death by apoptosis and blocked caspase-3 cleavage.	Carbachol	130-139	caspase 3	Homo sapiens	198-207
16439036-4	2006	Activation of Akt by carbachol was antagonized by atropine and inhibited by LY294002 and PP2.	Carbachol	21-30	AKT serine/threonine kinase 1	Homo sapiens	14-17
16439036-4	2006	Activation of Akt by carbachol was antagonized by atropine and inhibited by LY294002 and PP2.	Carbachol	21-30	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	89-92
16439036-5	2006	The Src-like tyrosine kinase inhibitor, PP2, also reduced carbachol stimulation of extracellular signal-regulated kinases 1/2 and cAMP-response element binding protein in a dose-dependent manner.	Carbachol	58-67	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	40-43
16439036-5	2006	The Src-like tyrosine kinase inhibitor, PP2, also reduced carbachol stimulation of extracellular signal-regulated kinases 1/2 and cAMP-response element binding protein in a dose-dependent manner.	Carbachol	58-67	mitogen-activated protein kinase 3	Homo sapiens	83-125
16439036-6	2006	Furthermore, carbachol increased tyrosine-phosphorylation of Fyn, a member of the Src-like tyrosine kinases.	Carbachol	13-22	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	61-64
16546360-2	2006	Carbachol and PGE(2) increase endogenous PGE(2) production and the COX-1 mRNA levels by activation of PLA(2)s. The COX-1 and COX-2 activity participated in the production of PGE(2) triggered by exogenous PGE(2).	Carbachol	0-9	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	67-72
16546360-2	2006	Carbachol and PGE(2) increase endogenous PGE(2) production and the COX-1 mRNA levels by activation of PLA(2)s. The COX-1 and COX-2 activity participated in the production of PGE(2) triggered by exogenous PGE(2).	Carbachol	0-9	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	115-120
16546360-2	2006	Carbachol and PGE(2) increase endogenous PGE(2) production and the COX-1 mRNA levels by activation of PLA(2)s. The COX-1 and COX-2 activity participated in the production of PGE(2) triggered by exogenous PGE(2).	Carbachol	0-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	125-130
16680828-4	2006	Carbachol-stimulated glutamate release was prolonged by perfusion of the selective D2 dopamine receptor antagonist raclopride (100 microM) into the SN and was attenuated by the perfusion of the selective D2-like receptor agonist quinpirole (10 microM).	Carbachol	0-9	dopamine receptor D2	Rattus norvegicus	83-103
16236826-0	2006	Ouabain potentiates the activation of ERK1/2 by carbachol in parotid gland epithelial cells; inhibition of ERK1/2 reduces Na(+)-K(+)-ATPase activity.	Carbachol	48-57	mitogen activated protein kinase 3	Rattus norvegicus	38-44
16236826-8	2006	Although ERK1/2 is only modestly phosphorylated when cells are exposed to 1 mM ouabain or 10(-6) M carbachol, the combination of these agents promotes ERK1/2 phosphorylation to near-maximal levels achieved by a log order carbachol concentration.	Carbachol	99-108	mitogen activated protein kinase 3	Rattus norvegicus	9-15
16236826-8	2006	Although ERK1/2 is only modestly phosphorylated when cells are exposed to 1 mM ouabain or 10(-6) M carbachol, the combination of these agents promotes ERK1/2 phosphorylation to near-maximal levels achieved by a log order carbachol concentration.	Carbachol	99-108	mitogen activated protein kinase 3	Rattus norvegicus	151-157
16236826-8	2006	Although ERK1/2 is only modestly phosphorylated when cells are exposed to 1 mM ouabain or 10(-6) M carbachol, the combination of these agents promotes ERK1/2 phosphorylation to near-maximal levels achieved by a log order carbachol concentration.	Carbachol	221-230	mitogen activated protein kinase 3	Rattus norvegicus	9-15
16236826-8	2006	Although ERK1/2 is only modestly phosphorylated when cells are exposed to 1 mM ouabain or 10(-6) M carbachol, the combination of these agents promotes ERK1/2 phosphorylation to near-maximal levels achieved by a log order carbachol concentration.	Carbachol	221-230	mitogen activated protein kinase 3	Rattus norvegicus	151-157
16236826-11	2006	In addition, inhibition of ERK1/2 reduces Na(+)-K(+)-ATPase activity (measured as stimulation of Qo(2) by carbachol and the cationophore nystatin).	Carbachol	106-115	mitogen activated protein kinase 3	Rattus norvegicus	27-33
15979279-4	2006	Western blotting analysis using a phosphospecific anti-Akt antibody revealed a dose- and time-dependent increase in Akt phosphorylation in cells stimulated with mAChR specific agonist carbachol (CCh).	Carbachol	184-193	AKT serine/threonine kinase 1	Rattus norvegicus	55-58
15979279-4	2006	Western blotting analysis using a phosphospecific anti-Akt antibody revealed a dose- and time-dependent increase in Akt phosphorylation in cells stimulated with mAChR specific agonist carbachol (CCh).	Carbachol	184-193	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
15979279-4	2006	Western blotting analysis using a phosphospecific anti-Akt antibody revealed a dose- and time-dependent increase in Akt phosphorylation in cells stimulated with mAChR specific agonist carbachol (CCh).	Carbachol	195-198	AKT serine/threonine kinase 1	Rattus norvegicus	55-58
15979279-4	2006	Western blotting analysis using a phosphospecific anti-Akt antibody revealed a dose- and time-dependent increase in Akt phosphorylation in cells stimulated with mAChR specific agonist carbachol (CCh).	Carbachol	195-198	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
15979279-5	2006	Co-stimulation with CCh and NGF resulted in augmentation of Akt activity in a pertussis toxin (PTX)-sensitive manner, suggesting that M4 mAChR, but not M1 and M5 mAChRs, was associated with this synergistic Akt activation.	Carbachol	20-23	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
15979279-5	2006	Co-stimulation with CCh and NGF resulted in augmentation of Akt activity in a pertussis toxin (PTX)-sensitive manner, suggesting that M4 mAChR, but not M1 and M5 mAChRs, was associated with this synergistic Akt activation.	Carbachol	20-23	AKT serine/threonine kinase 1	Rattus norvegicus	207-210
15979279-7	2006	Additional experiments showed that CCh treatment augmented NGF-induced phosphorylation and degradation of the Akt-regulated translation regulator tuberin.	Carbachol	35-38	AKT serine/threonine kinase 1	Rattus norvegicus	110-113
15979279-7	2006	Additional experiments showed that CCh treatment augmented NGF-induced phosphorylation and degradation of the Akt-regulated translation regulator tuberin.	Carbachol	35-38	TSC complex subunit 2	Rattus norvegicus	146-153
16553779-6	2006	In contrast, SNX-482 (100 nm), a selective antagonist of R-type calcium channels containing the alpha1E (Cav2.3) subunit, attenuated carbachol inhibition of the somatic spike-evoked calcium transient.	Carbachol	133-142	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	96-103
16553779-6	2006	In contrast, SNX-482 (100 nm), a selective antagonist of R-type calcium channels containing the alpha1E (Cav2.3) subunit, attenuated carbachol inhibition of the somatic spike-evoked calcium transient.	Carbachol	133-142	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	105-111
16567411-7	2006	Exogenous expression of antisense RNA encoding the rat canonical-transient receptor potential Ca2+ channel subtype 6 (TRPC6) or the N-terminal domain of TRPC6 blocks carbachol-stimulated Ba2+ influx in PC12D cells.	Carbachol	166-175	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	55-116
16567411-7	2006	Exogenous expression of antisense RNA encoding the rat canonical-transient receptor potential Ca2+ channel subtype 6 (TRPC6) or the N-terminal domain of TRPC6 blocks carbachol-stimulated Ba2+ influx in PC12D cells.	Carbachol	166-175	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	118-123
16567411-7	2006	Exogenous expression of antisense RNA encoding the rat canonical-transient receptor potential Ca2+ channel subtype 6 (TRPC6) or the N-terminal domain of TRPC6 blocks carbachol-stimulated Ba2+ influx in PC12D cells.	Carbachol	166-175	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	153-158
16316991-4	2006	Employing caspase-3 for IP3R cleavage, we show that Cch promotes polyubiquitination in the N-terminal domain and monoubiquitination in the C-terminal domain.	Carbachol	52-55	caspase-3	Cricetulus griseus	10-19
16227319-9	2006	The present study shows that Lyn kinase is expressed in human cultured airway smooth muscle cells at both the mRNA and protein levels and that carbachol, an M2 muscarinic receptor agonist in these cells, activates Lyn kinase by a pertussis toxin-insensitive signaling pathway.	Carbachol	143-152	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	214-217
16243961-11	2006	Inhibition of rho kinase, PKA, and PKG with N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide.2HCl (H89) reduces carbachol maximum and carbachol potency.	Carbachol	123-132	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	26-29
16403946-6	2006	The abnormal vascular responsiveness to endothelin-1, carbachol, and sodium nitroprusside in perfused mesenteric vascular bed of SHR-L-NAME was improved by ANG-(1-7) or captopril, with no additive effect of ANG-(1-7) + captopril.	Carbachol	54-63	angiogenin	Rattus norvegicus	156-164
16472591-2	2006	The present study was designed to examine the role of SLC26A6 in prostaglandin E(2) (PGE(2))-, forskolin-, and carbachol-induced duodenal HCO(3)(-) secretion.	Carbachol	111-120	solute carrier family 26, member 6	Mus musculus	54-61
16472591-4	2006	RESULTS: Basal HCO(3)(-) secretion was diminished by 20%, PGE(2)-stimulated HCO(3)(-) secretory response by 59%, and carbachol-stimulated response was reduced by 35% in SLC26A6-/- compared with +/+ duodenal mucosa, whereas the forskolin-stimulated HCO(3)(-) secretory response was not different.	Carbachol	117-126	solute carrier family 26, member 6	Mus musculus	169-176
16243961-9	2006	Inhibition of rho kinase, protein kinase A (PKA), and protein kinase G (PKG) with 1-(5-isoquinolinesulfonyl)-homopiperazine.HCl (HA-1077) reduces the carbachol maximal contraction, carbachol potency, and darifenacin affinity.	Carbachol	150-159	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	26-42
16243961-9	2006	Inhibition of rho kinase, protein kinase A (PKA), and protein kinase G (PKG) with 1-(5-isoquinolinesulfonyl)-homopiperazine.HCl (HA-1077) reduces the carbachol maximal contraction, carbachol potency, and darifenacin affinity.	Carbachol	150-159	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	44-47
16243962-10	2006	Inhibition of rho kinase, protein kinase A (PKA), and protein kinase G (PKG) with 1-(5-isoquinolinesulfonyl)-homopiperazine.HCl (HA-1077) reduces the carbachol maximum and potency.	Carbachol	150-159	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	26-42
16243962-10	2006	Inhibition of rho kinase, protein kinase A (PKA), and protein kinase G (PKG) with 1-(5-isoquinolinesulfonyl)-homopiperazine.HCl (HA-1077) reduces the carbachol maximum and potency.	Carbachol	150-159	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	44-47
16456221-5	2006	Both the muscarinic GPCR agonist carbachol and the ER Ca2+-adenosine triphosphate inhibitor thapsigargin (Tg) induced [Ca2+]i oscillations in NT2 cells.	Carbachol	33-42	C-X-C motif chemokine receptor 6	Homo sapiens	20-24
21186577-6	2006	CONCLUSION: The results above suggest that i. c. v. injection of cholinergic agonist carbachol can enhance the activity of adrenergic neurons and the expression of AT1 receptor in locus coeruleus.	Carbachol	85-94	angiotensin II receptor, type 1a	Rattus norvegicus	164-167
21186577-7	2006	The blockade of AT1 receptor may down regulate the above action induced by carbachol in locus coeruleus.	Carbachol	75-84	angiotensin II receptor, type 1a	Rattus norvegicus	16-19
16354194-7	2005	In the presence of the agonist carbachol, the effects of SLURP-1 on gene expression were augmented, which is in keeping with the notion that SLURP-1 acts as an allosteric agonist at the KC nAChR.	Carbachol	31-40	secreted LY6/PLAUR domain containing 1	Homo sapiens	57-64
16354194-7	2005	In the presence of the agonist carbachol, the effects of SLURP-1 on gene expression were augmented, which is in keeping with the notion that SLURP-1 acts as an allosteric agonist at the KC nAChR.	Carbachol	31-40	secreted LY6/PLAUR domain containing 1	Homo sapiens	141-148
16354194-7	2005	In the presence of the agonist carbachol, the effects of SLURP-1 on gene expression were augmented, which is in keeping with the notion that SLURP-1 acts as an allosteric agonist at the KC nAChR.	Carbachol	31-40	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	189-194
16324225-0	2005	Restoration by VIP of the carbachol-stimulated Cl- secretion in TTX-treated guinea pig distal colon.	Carbachol	26-35	VIP peptides	Cavia porcellus	15-18
16324225-5	2005	However, a serosal application, not mucosal, of VIP (10(-7) M) and 8-bromo-cAMP (10(-3) M) restored the Cch-stimulated, TTX-inhibited I(sc) by 113% and 75.8%, respectively.	Carbachol	104-107	VIP peptides	Cavia porcellus	48-51
16183168-2	2005	In the present study, we reported that carbachol, a muscarinic cholinergic receptor agonist, regulated Bim in human SH-SY5Y neuroblastoma cells.	Carbachol	39-48	BCL2 like 11	Homo sapiens	103-106
16183168-3	2005	Carbachol rapidly induced an upward gel mobility shift of Bim, which was abolished by protein phosphatase treatment, indicating an increased Bim phosphorylation by carbachol.	Carbachol	0-9	BCL2 like 11	Homo sapiens	58-61
16183168-3	2005	Carbachol rapidly induced an upward gel mobility shift of Bim, which was abolished by protein phosphatase treatment, indicating an increased Bim phosphorylation by carbachol.	Carbachol	0-9	BCL2 like 11	Homo sapiens	141-144
16183168-3	2005	Carbachol rapidly induced an upward gel mobility shift of Bim, which was abolished by protein phosphatase treatment, indicating an increased Bim phosphorylation by carbachol.	Carbachol	164-173	BCL2 like 11	Homo sapiens	58-61
16183168-3	2005	Carbachol rapidly induced an upward gel mobility shift of Bim, which was abolished by protein phosphatase treatment, indicating an increased Bim phosphorylation by carbachol.	Carbachol	164-173	BCL2 like 11	Homo sapiens	141-144
16183168-4	2005	The effect of carbachol was mimicked by the protein kinase C activator 12-myristate 13-acetate (PMA) and was blocked by the protein kinase C inhibitor rottlerin, suggesting that activation of protein kinase C was required for carbachol-induced phosphorylation of Bim.	Carbachol	14-23	BCL2 like 11	Homo sapiens	263-266
16183168-4	2005	The effect of carbachol was mimicked by the protein kinase C activator 12-myristate 13-acetate (PMA) and was blocked by the protein kinase C inhibitor rottlerin, suggesting that activation of protein kinase C was required for carbachol-induced phosphorylation of Bim.	Carbachol	226-235	BCL2 like 11	Homo sapiens	263-266
16183168-5	2005	Prolonged treatment with carbachol and PMA significantly decreased Bim protein levels in total cell lysates and mitrochondria.	Carbachol	25-34	BCL2 like 11	Homo sapiens	67-70
16183168-6	2005	Carbachol and PMA had no effect in the transcriptional regulation of Bim, whereas the reduction of Bim by both carbachol and PMA was reversed by the proteosome inhibitors, suggesting that carbachol and PMA facilitated the proteosome-dependent Bim degradation.	Carbachol	111-120	BCL2 like 11	Homo sapiens	99-102
16183168-6	2005	Carbachol and PMA had no effect in the transcriptional regulation of Bim, whereas the reduction of Bim by both carbachol and PMA was reversed by the proteosome inhibitors, suggesting that carbachol and PMA facilitated the proteosome-dependent Bim degradation.	Carbachol	111-120	BCL2 like 11	Homo sapiens	99-102
16183168-6	2005	Carbachol and PMA had no effect in the transcriptional regulation of Bim, whereas the reduction of Bim by both carbachol and PMA was reversed by the proteosome inhibitors, suggesting that carbachol and PMA facilitated the proteosome-dependent Bim degradation.	Carbachol	188-197	BCL2 like 11	Homo sapiens	99-102
16183168-6	2005	Carbachol and PMA had no effect in the transcriptional regulation of Bim, whereas the reduction of Bim by both carbachol and PMA was reversed by the proteosome inhibitors, suggesting that carbachol and PMA facilitated the proteosome-dependent Bim degradation.	Carbachol	188-197	BCL2 like 11	Homo sapiens	99-102
16387931-9	2006	Adventitially, trypsin, thrombin and PAR4 AP (but not PAR2 AP) relaxed carbachol-toned airways after &lt;3 min.	Carbachol	71-80	coagulation factor II, thrombin	Sus scrofa	24-32
16280365-2	2006	A novel finding was that brief exposure of airway smooth muscle cells to IL-4 inhibited carbachol-stimulated calcium transients.	Carbachol	88-97	interleukin 4	Bos taurus	73-77
16967497-0	2006	Microinjection of carbachol in the supramammillary region suppresses CA1 pyramidal cell synaptic excitability.	Carbachol	18-27	carbonic anhydrase 1	Rattus norvegicus	69-72
16967497-4	2006	It was observed that microinjection of the cholinergic muscarinic receptor agonist, carbachol (0.1 microl, concentration of either 0.0052, 0.156, or 0.625 microg/microl), evoked concentration-dependent suppression of CA1 pyramidal cell excitability that was dissociated from theta activation.	Carbachol	84-93	carbonic anhydrase 1	Rattus norvegicus	217-220
16331108-6	2006	Apocynin abolished these effects of Ang II in a specific manner, as carbachol-induced increases in MAP were unaffected by the inhibition of NAD(P)H oxidase (MAP increased by 9 +/- 2 and 8 +/- 1 mmHg in the absence and presence of apocynin, respectively).	Carbachol	68-77	angiotensinogen	Rattus norvegicus	36-42
16785762-5	2006	RESULTS: Carbachol (a muscarinic acetylcholine agonist) and isoproterenol (a beta-adrenergic agonist) markedly activated CREB in parotid acinar cells.	Carbachol	9-18	cAMP responsive element binding protein 1	Mus musculus	121-125
16785762-6	2006	Carbachol and isoproterenol-induced CREB phosphorylation was blocked by atropine (a muscarinic acetylcholine antagonist) and propranolol (a beta-adrenergic antagonist), respectively.	Carbachol	0-9	cAMP responsive element binding protein 1	Mus musculus	36-40
16785762-8	2006	Moreover, carbachol- and isoproterenol-stimulated amylase secretion from parotid acinar cells was inhibited by H89 and adenoviral dominant-negative CREB.	Carbachol	10-19	cAMP responsive element binding protein 1	Mus musculus	148-152
16216227-7	2005	Microinjection of the cholinoceptor agonist carbachol, the cholinesterase inhibitor physostigmine and the excitatory amino acid glutamate into the PHN caused increases in firing rate of AHA angiotensin-II-sensitive neurons in anesthetized WKY and SHR.	Carbachol	44-53	angiotensinogen	Rattus norvegicus	190-204
16330775-6	2005	In addition, carbachol-induced oscillations were obliterated in hippocampal slices of PLC-beta1(-/-) mice.	Carbachol	13-22	phospholipase C, beta 1	Mus musculus	86-95
16141265-3	2005	By combining patch-clamp electrophysiology with local photolysis of caged carbachol to rapidly activate the alpha7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneurones in slices, we describe a novel transient up-regulation of channel function.	Carbachol	74-83	carbonic anhydrase 1	Rattus norvegicus	152-155
16000638-1	2005	In secretory epithelia, activation of PKC by phorbol ester and carbachol negatively regulates Cl(-) secretion, the transport event of secretory diarrhea.	Carbachol	63-72	proline rich transmembrane protein 2	Homo sapiens	38-41
16000638-9	2005	Like PMA, carbachol reduced the amount of NKCC1 accessible to basolateral surface biotinylation in a PKC-epsilon-dependent manner.	Carbachol	10-19	solute carrier family 12 member 2	Homo sapiens	42-47
16000638-9	2005	Like PMA, carbachol reduced the amount of NKCC1 accessible to basolateral surface biotinylation in a PKC-epsilon-dependent manner.	Carbachol	10-19	proline rich transmembrane protein 2	Homo sapiens	101-104
16000638-10	2005	However, long-term exposure to carbachol did not result in degradation of NKCC1; rather, NKCC1 that was internalized after exposure to carbachol was recycled back to the cell membrane.	Carbachol	31-40	solute carrier family 12 member 2	Homo sapiens	89-94
16000638-10	2005	However, long-term exposure to carbachol did not result in degradation of NKCC1; rather, NKCC1 that was internalized after exposure to carbachol was recycled back to the cell membrane.	Carbachol	135-144	solute carrier family 12 member 2	Homo sapiens	89-94
16129413-4	2005	In SH-SY5Y cells expressing NPFF(2) receptors dNPA, in the presence of carbachol, stimulates Ca(2+) release from the intracellular stores.	Carbachol	71-80	pro-FMRFamide-related neuropeptide FF	Cricetulus griseus	28-32
16293767-6	2005	Interestingly, the increased responsiveness to CCh and OT was associated with an up-regulation of PLCbeta1 and PLCbeta3 enzymes.	Carbachol	47-50	phospholipase C beta 1	Rattus norvegicus	98-106
16293767-6	2005	Interestingly, the increased responsiveness to CCh and OT was associated with an up-regulation of PLCbeta1 and PLCbeta3 enzymes.	Carbachol	47-50	phospholipase C beta 3	Rattus norvegicus	111-119
16144656-7	2005	Microinjection of carbachol, physostigmine and glutamate into the PHN caused an increase in firing rate of AHA angiotensin II-sensitive neurons in anesthetized rats.	Carbachol	18-27	angiotensinogen	Rattus norvegicus	111-125
16144656-8	2005	The carbachol-induced increase of firing rate was inhibited by pressure application of the AT1 receptor antagonist losartan onto AHA angiotensin II-sensitive neurons.	Carbachol	4-13	angiotensinogen	Rattus norvegicus	133-147
15930141-5	2005	The chemical inhibitor GF-109203X (10 microM, 3 h), which inhibits PKC-alpha, -beta, -delta, and -epsilon, also elicited more potent inhibition of carbachol-stimulated secretion relative to Go-6976 (10 microM, 3 h), which inhibits only PKC-alpha and -beta.	Carbachol	147-156	protein kinase C alpha type	Oryctolagus cuniculus	236-255
16219687-2	2005	Here we use time-lapse confocal fluorescence microscopy and fluorescence recovery after photobleaching to investigate the changes in actin filaments located beneath the apical membrane during exocytosis evoked by the muscarinic agonist, carbachol (100 microM).	Carbachol	237-246	actin	Oryctolagus cuniculus	133-138
16219687-4	2005	Carbachol markedly increased apical actin filament turnover and also promoted transient actin assembly around apparent fusion intermediates.	Carbachol	0-9	actin	Oryctolagus cuniculus	36-41
16219687-4	2005	Carbachol markedly increased apical actin filament turnover and also promoted transient actin assembly around apparent fusion intermediates.	Carbachol	0-9	actin	Oryctolagus cuniculus	88-93
16219687-5	2005	Fluorescence recovery after photobleaching measurements revealed significant (P&lt; or =0.05) increases and decreases, respectively, in mobile fraction (Mf) and turnover times (t1/2) for apical actin filaments in carbachol-stimulated acini relative to untreated acini.	Carbachol	213-222	actin	Oryctolagus cuniculus	194-199
16219687-6	2005	The myosin inhibitors, 2,3-butanedione monoxime (BDM, 10 mM, 15 minutes) and ML-7 (40 microM, 15 minutes), significantly decreased carbachol-stimulated secretion of bulk protein and the exogenous secretory vesicle marker, syncollin-GFP; these agents also promoted accumulation of actin-coated structures which were enriched, in transduced acini, in syncollin-GFP, confirming their identity as fusion intermediates.	Carbachol	131-140	actin	Oryctolagus cuniculus	280-285
15928025-11	2005	Overexpression of PANDER in mouse islets or addition of recombinant PANDER decreased insulin secretion induced by carbachol plus glucose or high potassium but not that by glucose alone.	Carbachol	114-123	FAM3 metabolism regulating signaling molecule B	Mus musculus	18-24
15928025-11	2005	Overexpression of PANDER in mouse islets or addition of recombinant PANDER decreased insulin secretion induced by carbachol plus glucose or high potassium but not that by glucose alone.	Carbachol	114-123	FAM3 metabolism regulating signaling molecule B	Mus musculus	68-74
16107881-3	2005	Here, we show that intracellular Ca2+ mobilization via the purinergic receptor agonist ATP, the muscarinic receptor agonist carbachol or the Ca(2+)-ATPase inhibitor thapsigargin leads to formation of anandamide, and subsequent TRPV1-dependent Ca2+ influx in transfected cells and sensory neurons of rat dorsal root ganglia (DRG).	Carbachol	124-133	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	227-232
16093422-4	2005	Pretreatment with TNF-alpha (100 ng/ml) hyperpolarized the membrane (from -31.0 +/- 2.7 mV under control conditions to -61.2 +/- 3.2 mV in the presence of the cytokine) and potentiated the depolarization induced by carbachol (from 5.2 +/- 0.7 mV under control conditions to 27.5 +/- 2.0 mV in the presence of the cytokine).	Carbachol	215-224	tumor necrosis factor	Rattus norvegicus	18-27
16045692-11	2005	After addition of carbachol to the upper compartment, an increase of fibronectin induced chemotaxis of approximately 30% was observed, an effect abrogated by atropine.	Carbachol	18-27	fibronectin 1	Homo sapiens	69-80
15937149-5	2005	Calcium entry through SOCs induced by the calcium-ATPase inhibitor thapsigargin or the receptor agonists UTP or carbachol inhibited guanylyl cyclase C-dependent cGMP accumulation.	Carbachol	112-121	guanylate cyclase 2C	Homo sapiens	132-150
15843439-3	2005	TRPC5 was initially activated by muscarinic stimulation using 100 microM carbachol (CCh) and then decayed rapidly even in the presence of CCh (desensitization).	Carbachol	73-82	transient receptor potential cation channel subfamily C member 5	Homo sapiens	0-5
15843439-3	2005	TRPC5 was initially activated by muscarinic stimulation using 100 microM carbachol (CCh) and then decayed rapidly even in the presence of CCh (desensitization).	Carbachol	84-87	transient receptor potential cation channel subfamily C member 5	Homo sapiens	0-5
15843439-3	2005	TRPC5 was initially activated by muscarinic stimulation using 100 microM carbachol (CCh) and then decayed rapidly even in the presence of CCh (desensitization).	Carbachol	138-141	transient receptor potential cation channel subfamily C member 5	Homo sapiens	0-5
15843439-5	2005	The protein kinase C (PKC) inhibitors, 1 microM chelerythrine, 100 nM GF109203X, or PKC peptide inhibitor (19-36), inhibited this desensitization of TRPC5 activated by 100 microM CCh.	Carbachol	179-182	transient receptor potential cation channel subfamily C member 5	Homo sapiens	149-154
15744749-1	2005	Carbachol (Cch), a muscarinic acetylcholine receptor (mAChR) agonist, increases intracellular-free Ca(2+) mobilization and induces mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) phosphorylation in MCF-7 human breast cancer cells.	Carbachol	0-9	mitogen-activated protein kinase 1	Homo sapiens	208-211
15744749-1	2005	Carbachol (Cch), a muscarinic acetylcholine receptor (mAChR) agonist, increases intracellular-free Ca(2+) mobilization and induces mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) phosphorylation in MCF-7 human breast cancer cells.	Carbachol	11-14	mitogen-activated protein kinase 1	Homo sapiens	208-211
15744749-3	2005	Phosphorylation of MAPK/ERK was mimicked by phorbol 12-myristate acetate (PMA), an activator of protein kinase C (PKC), but Cch-evoked MAPK/ERK activation was unaffected by down-regulation of PKC or by pretreatment of cells with GF109203X, a PKC inhibitor.	Carbachol	124-127	mitogen-activated protein kinase 1	Homo sapiens	140-143
15744749-3	2005	Phosphorylation of MAPK/ERK was mimicked by phorbol 12-myristate acetate (PMA), an activator of protein kinase C (PKC), but Cch-evoked MAPK/ERK activation was unaffected by down-regulation of PKC or by pretreatment of cells with GF109203X, a PKC inhibitor.	Carbachol	124-127	protein kinase C zeta	Homo sapiens	192-195
15744749-3	2005	Phosphorylation of MAPK/ERK was mimicked by phorbol 12-myristate acetate (PMA), an activator of protein kinase C (PKC), but Cch-evoked MAPK/ERK activation was unaffected by down-regulation of PKC or by pretreatment of cells with GF109203X, a PKC inhibitor.	Carbachol	124-127	protein kinase C zeta	Homo sapiens	192-195
16099848-8	2005	In an ex vivo assay, we found that the Ca2+-dependent (carbachol-stimulated) glycoprotein secretion strongly inhibited by the calcium-activated chloride channel blocker niflumic acid (100 microm) was impaired in the distal colon of cftr-/- mice.	Carbachol	55-64	cystic fibrosis transmembrane conductance regulator	Mus musculus	232-236
15935407-5	2005	The nicotinic acetylcholine receptor antagonist, mecamylamine (5.0 and 10.0 microg), injected into the nucleus accumbens shell, which alone did not elicit any turning behaviour, significantly suppressed both the contraversive circling induced by carbachol (5.0 microg) and the contraversive pivoting induced by the mixture of SKF 38393 (5.0 microg) and quinpirole (10.0 microg).	Carbachol	246-255	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	4-36
16083715-5	2005	RESULTS: EGF pretreatment of normal colonic mucosa inhibited ion transport responses to carbachol and forskolin but potentiated the reduced ion transport responses seen in dextran sulfate sodium (DSS)-treated and mdr1a knockout mouse colon.	Carbachol	88-97	epidermal growth factor	Mus musculus	9-12
15744749-4	2005	However, Cch-stimulated MAPK/ERK phosphorylation was completely blocked by myristoylated PKC-zeta pseudosubstrate, a specific inhibitor of PKC-zeta, and high doses of staurosporine.	Carbachol	9-12	mitogen-activated protein kinase 1	Homo sapiens	29-32
15744749-4	2005	However, Cch-stimulated MAPK/ERK phosphorylation was completely blocked by myristoylated PKC-zeta pseudosubstrate, a specific inhibitor of PKC-zeta, and high doses of staurosporine.	Carbachol	9-12	protein kinase C zeta	Homo sapiens	89-97
15744749-4	2005	However, Cch-stimulated MAPK/ERK phosphorylation was completely blocked by myristoylated PKC-zeta pseudosubstrate, a specific inhibitor of PKC-zeta, and high doses of staurosporine.	Carbachol	9-12	protein kinase C zeta	Homo sapiens	139-147
15744749-5	2005	Pretreatment of human breast cancer cells with wortmannin or LY294002, selective inhibitors of phosphoinositide 3-kinase (PI3K), diminished Cch-mediated MAPK/ERK phosphorylation.	Carbachol	140-143	mitogen-activated protein kinase 1	Homo sapiens	158-161
15894801-5	2005	Moreover, RyR1 and/or RyR3 in mouse airway smooth muscle also appear to mediate bronchoconstriction caused by the muscarinic receptor agonist carbachol.	Carbachol	142-151	ryanodine receptor 1, skeletal muscle	Mus musculus	10-14
15963958-6	2005	Microinjection of carbachol into the LSV caused an increase in firing rate of AHA angiotensin II-sensitive neurons.	Carbachol	18-27	angiotensinogen	Rattus norvegicus	82-96
15963958-7	2005	The carbachol-induced increase of firing rate of AHA angiotensin II-sensitive neurons was inhibited by pressure application of the excitatory amino acid receptor antagonist kynurenate but not by the AT1 receptor antagonist losartan onto the same neurons.	Carbachol	4-13	angiotensinogen	Rattus norvegicus	53-67
15963958-11	2005	It seems likely that the carbachol-induced activation of AHA angiotensin II-sensitive neurons is mainly mediated via excitatory amino acid receptors at AHA neurons.	Carbachol	25-34	angiotensinogen	Rattus norvegicus	61-75
15743890-3	2005	Secretagogues, including cholecystokinin (CCK) and the acetylcholine analog carbachol, increased the amount of GTP-bound RhoA and Rac1 and induced translocation from cytosol to a membrane fraction.	Carbachol	76-85	ras homolog family member A	Mus musculus	121-125
15743890-3	2005	Secretagogues, including cholecystokinin (CCK) and the acetylcholine analog carbachol, increased the amount of GTP-bound RhoA and Rac1 and induced translocation from cytosol to a membrane fraction.	Carbachol	76-85	Rac family small GTPase 1	Mus musculus	130-134
15885660-8	2005	We demonstrate that calcium chelation or inhibition of calmodulin attenuates the effect of carbachol on AC6 activation.	Carbachol	91-100	adenylate cyclase 6	Homo sapiens	104-107
15880140-8	2005	Atropine, propiverine and M-6 significantly shifted the cumulative concentration-response curves for carbachol (CCh) to higher concentrations.	Carbachol	101-110	homeobox A7	Mus musculus	26-29
15880140-8	2005	Atropine, propiverine and M-6 significantly shifted the cumulative concentration-response curves for carbachol (CCh) to higher concentrations.	Carbachol	112-115	homeobox A7	Mus musculus	26-29
15880140-10	2005	Propiverine, M-5 and M-14 reduced the maximum CCh effect, suggesting at least one additional mode of action.	Carbachol	46-49	cholinergic receptor, muscarinic 5	Mus musculus	13-16
15955028-6	2005	Carbachol stimulation of M(3) and M(4) muscarinic AChR increased contractility, IPs accumulation, NOS activity and cGMP production.	Carbachol	0-9	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	50-54
15955028-14	2005	The results obtained suggest that carbachol activation of M(3) and M(4) muscarinic AChRs, exerts a contractile effect on rat detrusor that is accompanied by an increased production of cGMP and nNOS activity.	Carbachol	34-43	nitric oxide synthase 1	Rattus norvegicus	193-197
16012943-9	2005	Incubation of tissue with IL-4, IL-13, TGF-beta1, or PGE 2 enhanced carbachol-induced muscle cell contractility ( P &lt; .05).	Carbachol	68-77	interleukin 4	Mus musculus	26-30
16012943-9	2005	Incubation of tissue with IL-4, IL-13, TGF-beta1, or PGE 2 enhanced carbachol-induced muscle cell contractility ( P &lt; .05).	Carbachol	68-77	interleukin 13	Mus musculus	32-37
16012943-9	2005	Incubation of tissue with IL-4, IL-13, TGF-beta1, or PGE 2 enhanced carbachol-induced muscle cell contractility ( P &lt; .05).	Carbachol	68-77	transforming growth factor, beta 1	Mus musculus	39-48
15894801-5	2005	Moreover, RyR1 and/or RyR3 in mouse airway smooth muscle also appear to mediate bronchoconstriction caused by the muscarinic receptor agonist carbachol.	Carbachol	142-151	ryanodine receptor 3	Mus musculus	22-26
15894801-6	2005	Inhibiting all RyR isoforms with &gt; or = 200 microM ryanodine attenuated the graded carbachol-induced contractile responses of mouse bronchial rings and calcium responses of ASMCs throughout the range of carbachol used (50 nM to &gt; or = 3 microM).	Carbachol	86-95	ryanodine receptor 2, cardiac	Mus musculus	15-18
15894801-6	2005	Inhibiting all RyR isoforms with &gt; or = 200 microM ryanodine attenuated the graded carbachol-induced contractile responses of mouse bronchial rings and calcium responses of ASMCs throughout the range of carbachol used (50 nM to &gt; or = 3 microM).	Carbachol	206-215	ryanodine receptor 2, cardiac	Mus musculus	15-18
15978011-8	2005	At network level, the effect of zolpidem (10 microm) on carbachol-induced oscillations in the CA3 area of gamma2I77/I77 mice was significantly different compared with controls.	Carbachol	56-65	carbonic anhydrase 3	Mus musculus	94-97
15894015-3	2005	Carbachol (CCh) caused translocations of PKC-alpha, betaII, delta, and epsilon from the cytosol to the plasma membrane.	Carbachol	0-9	protein kinase C, alpha	Rattus norvegicus	41-50
15894015-3	2005	Carbachol (CCh) caused translocations of PKC-alpha, betaII, delta, and epsilon from the cytosol to the plasma membrane.	Carbachol	11-14	protein kinase C, alpha	Rattus norvegicus	41-50
15894015-5	2005	The CCh-stimulated insulin secretion was significantly suppressed by the generic PKC inhibitor chelerythrine.	Carbachol	4-7	protein kinase C, alpha	Rattus norvegicus	81-84
15894015-7	2005	These results suggest that the novel PKC isoforms activated by CCh, i.e., PKC-delta and/or epsilon, participate in the stimulatory effect of CCh on insulin secretion.	Carbachol	63-66	protein kinase C, alpha	Rattus norvegicus	37-40
15894015-7	2005	These results suggest that the novel PKC isoforms activated by CCh, i.e., PKC-delta and/or epsilon, participate in the stimulatory effect of CCh on insulin secretion.	Carbachol	141-144	protein kinase C, alpha	Rattus norvegicus	37-40
15779001-5	2005	The muscarinic agonist carbachol more efficiently promoted stress fiber formation and tyrosine phosphorylation of focal adhesion-associated proteins in M3 receptor-expressing cells adherent to fibronectin or collagen type I, as compared to polylysine.	Carbachol	23-32	fibronectin 1	Homo sapiens	193-204
15779001-7	2005	However, total levels of MAPK and mitogen-activated protein kinase kinase (MEK) in the nucleus were significantly greater in cells adherent to ECM proteins for 2.5 h, and levels of activated MAPK and MEK in the nuclei of these cells were higher following carbachol stimulation, relative to levels in cells adherent to polylysine.	Carbachol	255-264	mitogen-activated protein kinase kinase 7	Homo sapiens	75-78
15779001-7	2005	However, total levels of MAPK and mitogen-activated protein kinase kinase (MEK) in the nucleus were significantly greater in cells adherent to ECM proteins for 2.5 h, and levels of activated MAPK and MEK in the nuclei of these cells were higher following carbachol stimulation, relative to levels in cells adherent to polylysine.	Carbachol	255-264	mitogen-activated protein kinase kinase 7	Homo sapiens	200-203
15855345-0	2005	Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia.	Carbachol	40-49	insulin	Homo sapiens	59-66
15855345-3	2005	At concentrations encompassing therapeutically relevant levels, olanzapine and clozapine reduced insulin secretion stimulated by 10 micromol/l carbachol plus 7 mmol/l glucose.	Carbachol	143-152	insulin	Homo sapiens	97-104
15855345-4	2005	This inhibition of insulin secretion was paralleled by significant reductions in carbachol-potentiated inositol phosphate accumulation.	Carbachol	81-90	insulin	Homo sapiens	19-26
15862177-5	2005	In the presence of both the CB1 antagonist AM251 (10(-6)m) and CP 55,940 (10(-5)m), the contractile response to carbachol reached 84+/-3% (n=6) of the original level.	Carbachol	112-121	cannabinoid receptor 1	Homo sapiens	28-31
15760932-6	2005	Uncoupling the receptor-mediated activation of cytosolic phospholipase A(2) (cPLA(2)) with isotetrandrine reduces the activation of the ARC channels by carbachol and, correspondingly, markedly inhibits the [Ca(2+)](i) signals induced by low carbachol concentrations, whilst those signals seen at high agonist concentrations are essentially unaffected.	Carbachol	152-161	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	47-84
15760932-6	2005	Uncoupling the receptor-mediated activation of cytosolic phospholipase A(2) (cPLA(2)) with isotetrandrine reduces the activation of the ARC channels by carbachol and, correspondingly, markedly inhibits the [Ca(2+)](i) signals induced by low carbachol concentrations, whilst those signals seen at high agonist concentrations are essentially unaffected.	Carbachol	241-250	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	47-84
16079011-5	2005	Stimulation of M(1) and M(3) mAChR with carbachol caused an increase in vessel diameter, in iNOS-mRNA levels and in NOS activity in the retina.	Carbachol	40-49	nitric oxide synthase 2	Rattus norvegicus	92-96
15857612-5	2005	Ca(2+) sensitization induced by phenylephrine, norepinephrine and carbachol was markedly antagonized by all three ROK inhibitors.	Carbachol	66-75	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	114-117
15848807-6	2005	Electrophysiological study showed that carbachol excites almost one-third of orexin neurons and inhibits a small population of orexin neurons.	Carbachol	39-48	hypocretin	Mus musculus	77-83
15848807-6	2005	Electrophysiological study showed that carbachol excites almost one-third of orexin neurons and inhibits a small population of orexin neurons.	Carbachol	39-48	hypocretin	Mus musculus	127-133
15528258-5	2005	Preincubation of human cultured smooth muscle cells with IL-4 (P &lt; 0.001) or IL-13 (P &lt; 0.05) significantly enhanced carbachol-induced contraction, and this was significantly inhibited by the STAT6 inhibitor leflunomide (P &lt; 0.0001).	Carbachol	123-132	interleukin 4	Homo sapiens	57-61
15893601-0	2005	From synapse to gene product: prolonged expression of c-fos induced by a single microinjection of carbachol in the pontomesencephalic tegmentum.	Carbachol	98-107	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-59
15893601-6	2005	These results demonstrate a sustained c-fos expression in response to pharmacological stimulation of the brain and suggest that carbachol"s acute effects induce LTPE via cholinergic receptors, with subsequent transsynaptic activation of the LDT/PPT maintaining the LTPE effect.	Carbachol	128-137	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
15893601-6	2005	These results demonstrate a sustained c-fos expression in response to pharmacological stimulation of the brain and suggest that carbachol"s acute effects induce LTPE via cholinergic receptors, with subsequent transsynaptic activation of the LDT/PPT maintaining the LTPE effect.	Carbachol	128-137	tachykinin precursor 1	Homo sapiens	245-248
15528258-5	2005	Preincubation of human cultured smooth muscle cells with IL-4 (P &lt; 0.001) or IL-13 (P &lt; 0.05) significantly enhanced carbachol-induced contraction, and this was significantly inhibited by the STAT6 inhibitor leflunomide (P &lt; 0.0001).	Carbachol	123-132	interleukin 13	Homo sapiens	80-85
15528258-5	2005	Preincubation of human cultured smooth muscle cells with IL-4 (P &lt; 0.001) or IL-13 (P &lt; 0.05) significantly enhanced carbachol-induced contraction, and this was significantly inhibited by the STAT6 inhibitor leflunomide (P &lt; 0.0001).	Carbachol	123-132	signal transducer and activator of transcription 6	Homo sapiens	198-203
15389641-1	2005	We have previously shown that the Gq protein coupled receptor (GqPCR) agonist, carbachol (CCh), transactivates and recruits epidermal growth factor receptor (EGFr)-dependent signaling mechanisms in intestinal epithelial cells.	Carbachol	79-88	epidermal growth factor receptor	Homo sapiens	124-156
15757506-4	2005	3 In diabetic carotid artery, the vasoconstrictor responses induced by noradrenaline (NE), endothelin-1 (ET-1), and angiotensin II (Ang II), were significantly increased whereas vasodilator responses to carbachol and histamine were significantly reduced.	Carbachol	203-212	angiotensinogen	Rattus norvegicus	132-138
15389641-8	2005	CCh also induced association of FAK with the EGFr and FAK phosphorylation was attenuated by an EGFr inhibitor, tyrphostin AG1478, and an inhibitor of Src family kinases, PP2.	Carbachol	0-3	protein tyrosine kinase 2	Homo sapiens	32-35
15389641-1	2005	We have previously shown that the Gq protein coupled receptor (GqPCR) agonist, carbachol (CCh), transactivates and recruits epidermal growth factor receptor (EGFr)-dependent signaling mechanisms in intestinal epithelial cells.	Carbachol	79-88	epidermal growth factor receptor	Homo sapiens	158-162
15389641-8	2005	CCh also induced association of FAK with the EGFr and FAK phosphorylation was attenuated by an EGFr inhibitor, tyrphostin AG1478, and an inhibitor of Src family kinases, PP2.	Carbachol	0-3	epidermal growth factor receptor	Homo sapiens	45-49
15389641-1	2005	We have previously shown that the Gq protein coupled receptor (GqPCR) agonist, carbachol (CCh), transactivates and recruits epidermal growth factor receptor (EGFr)-dependent signaling mechanisms in intestinal epithelial cells.	Carbachol	90-93	epidermal growth factor receptor	Homo sapiens	124-156
15389641-8	2005	CCh also induced association of FAK with the EGFr and FAK phosphorylation was attenuated by an EGFr inhibitor, tyrphostin AG1478, and an inhibitor of Src family kinases, PP2.	Carbachol	0-3	protein tyrosine kinase 2	Homo sapiens	54-57
15389641-1	2005	We have previously shown that the Gq protein coupled receptor (GqPCR) agonist, carbachol (CCh), transactivates and recruits epidermal growth factor receptor (EGFr)-dependent signaling mechanisms in intestinal epithelial cells.	Carbachol	90-93	epidermal growth factor receptor	Homo sapiens	158-162
15389641-8	2005	CCh also induced association of FAK with the EGFr and FAK phosphorylation was attenuated by an EGFr inhibitor, tyrphostin AG1478, and an inhibitor of Src family kinases, PP2.	Carbachol	0-3	epidermal growth factor receptor	Homo sapiens	95-99
15389641-3	2005	Therefore, the aim of the present study was to investigate if CCh stimulates activation of the focal adhesion-associated protein, focal adhesion kinase (FAK), in intestinal epithelia and, if so, to examine the signaling mechanisms involved.	Carbachol	62-65	RNA 2',3'-cyclic phosphate and 5'-OH ligase	Homo sapiens	95-128
15389641-8	2005	CCh also induced association of FAK with the EGFr and FAK phosphorylation was attenuated by an EGFr inhibitor, tyrphostin AG1478, and an inhibitor of Src family kinases, PP2.	Carbachol	0-3	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	170-173
15389641-9	2005	The actin cytoskeleton disruptor, cytochalasin D (20 microM), abolished FAK phosphorylation in response to CCh but did not alter CCh-induced EGFr or ERK MAPK activation.	Carbachol	107-110	protein tyrosine kinase 2	Homo sapiens	72-75
15389641-3	2005	Therefore, the aim of the present study was to investigate if CCh stimulates activation of the focal adhesion-associated protein, focal adhesion kinase (FAK), in intestinal epithelia and, if so, to examine the signaling mechanisms involved.	Carbachol	62-65	protein tyrosine kinase 2	Homo sapiens	130-151
15389641-3	2005	Therefore, the aim of the present study was to investigate if CCh stimulates activation of the focal adhesion-associated protein, focal adhesion kinase (FAK), in intestinal epithelia and, if so, to examine the signaling mechanisms involved.	Carbachol	62-65	protein tyrosine kinase 2	Homo sapiens	153-156
15389641-5	2005	CCh rapidly induced tyrosine phosphorylation of FAK in T84 cells.	Carbachol	0-3	protein tyrosine kinase 2	Homo sapiens	48-51
15389641-7	2005	CCh-stimulated FAK phosphorylation was inhibited by a chelator of intracellular Ca2+, BAPTA/AM (20 microM), and was mimicked by thapsigargin (2 microM), which mobilizes intracellular Ca2+ in a receptor-independent fashion.	Carbachol	0-3	protein tyrosine kinase 2	Homo sapiens	15-18
15762196-7	2005	DESIGN AND METHODS: Ionomycin- and carbamylcholine-stimulated H2O2 generation was measured in dog thyroid cells pretreated with the Clostridium difficile toxin B, which inhibits Rac proteins.	Carbachol	35-50	Rac family small GTPase 1	Canis lupus familiaris	178-181
16245034-9	2005	The activation of apical Cl(-) conductance by carbachol was resistant against any blockers of the phospholipase C/IP3/protein kinase C pathway tested (e.g., U-73122, 2-ABP, Li(+), staurosporine), but was inhibited by the NO-synthase blocker L: -NNA.	Carbachol	46-55	glutamate receptor interacting protein 2	Rattus norvegicus	168-171
15634940-1	2005	In airway smooth muscle cells, interleukin (IL)-4 inhibited both carbachol- and caffeine-induced calcium mobilization from the sarcoplasmic reticulum (SR).	Carbachol	65-74	interleukin 4	Bos taurus	31-49
15634940-4	2005	Calcium transients in response to carbachol (10 microM) were significantly decreased to 0.34 +/- 0.10 of control after 20-min treatment with IL-4 but were 1.10 +/- 0.26 and 1.08 +/- 0.23 when wortmannin or deguelin, respectively, was added along with IL-4.	Carbachol	34-43	interleukin 4	Bos taurus	141-145
15634940-4	2005	Calcium transients in response to carbachol (10 microM) were significantly decreased to 0.34 +/- 0.10 of control after 20-min treatment with IL-4 but were 1.10 +/- 0.26 and 1.08 +/- 0.23 when wortmannin or deguelin, respectively, was added along with IL-4.	Carbachol	34-43	interleukin 4	Bos taurus	251-255
15814109-4	2005	Inhibitors of phospholipase A(2) (PLA(2)), COX and phospholipase C (PLC), calcium/calmodulin (CaM), NOS and soluble guanylate cyclase prevent the carbachol effect.	Carbachol	146-155	phospholipase A2 group IB	Rattus norvegicus	14-32
15647288-10	2005	Whereas whole-cell carbachol-induced TRPC3 current was blocked by 3 microM BTP2, single TRPC3 channel recordings revealed persistent short openings suggesting BTP2 reduces the open probability of the channel rather than its pore properties.	Carbachol	19-28	transient receptor potential cation channel subfamily C member 3	Homo sapiens	37-42
15716122-3	2005	We found that carbachol-pretreatment enhanced both VIP- and forskolin-activated AC activities.	Carbachol	14-23	vasoactive intestinal peptide	Rattus norvegicus	51-54
15626773-3	2005	ATR exhibited significantly higher sensitivity to carbachol than CTR.	Carbachol	50-59	ATR serine/threonine kinase	Homo sapiens	0-3
15626773-4	2005	Pretreatment of ATR with E(2) shifted the carbachol concentration-response curve (CCRC) toward that of CTR.	Carbachol	42-51	ATR serine/threonine kinase	Homo sapiens	16-19
15721621-6	2005	Carbachol-stimulation of M1/M3 mAChR increased nNOS-mRNA levels associated with an increase of endogenous NO and cGMP production.	Carbachol	0-9	nitric oxide synthase 1	Rattus norvegicus	47-51
15725947-7	2005	Third, the relaxant effect of carbachol was partially preserved in TAs of endothelial NOS deficient (eNOS-/-) animals and remained unchanged in the presence of indomethacin, indicating the involvement of an eNOS- and cyclooxygenase-independent mechanism in the mediation of the response.	Carbachol	30-39	nitric oxide synthase 3, endothelial cell	Mus musculus	74-89
15637297-6	2005	In contrast to WT, bradykinin- or carbachol-induced reduction in MVO2 was attenuated in nNOS-/-.	Carbachol	34-43	nitric oxide synthase 1, neuronal	Mus musculus	88-92
15707678-0	2005	High-affinity neurotensin receptor is involved in phosphoinositide hydrolysis stimulation by carbachol in neonatal rat brain.	Carbachol	93-102	neurotensin	Rattus norvegicus	14-25
15707678-5	2005	In 20-min incubation experiments, inositol phosphate accumulation by 10(-3) M carbachol was circa 240%, a value which attained 320-360% plus 10(-7) M neurotensin; this effect was totally blocked by 10(-7) M SR 48692.	Carbachol	78-87	neurotensin	Rattus norvegicus	150-161
15458922-13	2005	Stimulation of glands with carbachol, which elevates [Ca2+]i and activates PKC, induced apparent translocation of IQGAP1, but not IQGAP2, to apical poles of chief (zymogen) and mucous neck cells.	Carbachol	27-36	IQ motif containing GTPase activating protein 2	Homo sapiens	130-136
15377496-8	2005	Western blot showed that carbachol, but not histamine, caused intense phosphorylation of extracellular signal-regulated kinase 1/2 and that LTD(4) significantly enhanced the phosphorylation induced by histamine, but not by carbachol.	Carbachol	25-34	mitogen-activated protein kinase 3	Bos taurus	89-130
15987429-15	2005	Carbachol significantly increased VEGF expression in TMps, and this effect was totally reversed by methoctramine and pirenzepine.	Carbachol	0-9	vascular endothelial growth factor A	Mus musculus	34-38
16245207-5	2005	The results showed that the non hydrolysable agonist of mChR, carbachol (1 mM) together with GTP(g)S (100 microM) stimulated PARP-1 activity in the hippocampus by about 100%.	Carbachol	62-71	melanin-concentrating hormone receptor 1	Mus musculus	56-60
16245207-5	2005	The results showed that the non hydrolysable agonist of mChR, carbachol (1 mM) together with GTP(g)S (100 microM) stimulated PARP-1 activity in the hippocampus by about 100%.	Carbachol	62-71	poly(ADP-ribose) polymerase 1	Homo sapiens	125-131
16245207-6	2005	TMB-8, inhibitor of IP3 receptor decreased PARP-1 activation evoked by carbachol/GTP(g)S. Stimulation of mChR did not lead to free radicals generation but activate PARP-1 through IP3/Ca2+ regulated processes.	Carbachol	71-80	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	20-32
16245207-6	2005	TMB-8, inhibitor of IP3 receptor decreased PARP-1 activation evoked by carbachol/GTP(g)S. Stimulation of mChR did not lead to free radicals generation but activate PARP-1 through IP3/Ca2+ regulated processes.	Carbachol	71-80	poly(ADP-ribose) polymerase 1	Homo sapiens	43-49
16245207-6	2005	TMB-8, inhibitor of IP3 receptor decreased PARP-1 activation evoked by carbachol/GTP(g)S. Stimulation of mChR did not lead to free radicals generation but activate PARP-1 through IP3/Ca2+ regulated processes.	Carbachol	71-80	melanin-concentrating hormone receptor 1	Mus musculus	105-109
15649983-6	2005	Carbacholine (10(-4) M) significantly reduced tetanic force to 31 +/- 3% of controls, which underwent significant recovery upon application of Na+-K+ pump stimulators: salbutamol (10(-5) M), adrenaline (10(-5) M) and calcitonin gene-related peptide (CGRP; 10(-7) M).	Carbachol	0-12	calcitonin-related polypeptide alpha	Rattus norvegicus	217-248
15649983-6	2005	Carbacholine (10(-4) M) significantly reduced tetanic force to 31 +/- 3% of controls, which underwent significant recovery upon application of Na+-K+ pump stimulators: salbutamol (10(-5) M), adrenaline (10(-5) M) and calcitonin gene-related peptide (CGRP; 10(-7) M).	Carbachol	0-12	calcitonin-related polypeptide alpha	Rattus norvegicus	250-254
15721170-9	2005	These results strongly implicate 5-HT(1A) and 5-HT(2) receptors in the modulation of spectral power of carbachol-induced rhythmic activity and that 5-HT(1A) receptors are responsible for the prevailing effect of 5-HT.	Carbachol	103-112	5-hydroxytryptamine receptor 1A	Homo sapiens	33-40
15548524-10	2005	Interaction between PLD2 and tubulin was increased only after 1-2 min of carbachol stimulation when carbachol-stimulated PLD2 activity was decreased.	Carbachol	73-82	phospholipase D2	Homo sapiens	20-24
15548524-10	2005	Interaction between PLD2 and tubulin was increased only after 1-2 min of carbachol stimulation when carbachol-stimulated PLD2 activity was decreased.	Carbachol	100-109	phospholipase D2	Homo sapiens	20-24
15548524-10	2005	Interaction between PLD2 and tubulin was increased only after 1-2 min of carbachol stimulation when carbachol-stimulated PLD2 activity was decreased.	Carbachol	100-109	phospholipase D2	Homo sapiens	121-125
15548524-11	2005	The expression of the tubulin binding region of PLD2 blocked the later decrease in carbachol-induced PLD activity by masking tubulin binding.	Carbachol	83-92	phospholipase D2	Homo sapiens	48-52
15548524-11	2005	The expression of the tubulin binding region of PLD2 blocked the later decrease in carbachol-induced PLD activity by masking tubulin binding.	Carbachol	83-92	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	48-51
15458922-13	2005	Stimulation of glands with carbachol, which elevates [Ca2+]i and activates PKC, induced apparent translocation of IQGAP1, but not IQGAP2, to apical poles of chief (zymogen) and mucous neck cells.	Carbachol	27-36	IQ motif containing GTPase activating protein 1	Homo sapiens	114-120
15655501-4	2005	Genistein and daidzein antagonized the negative inotropic effect and the decrease in Ca(2+) transients induced by ET-1 by crosstalk with NE at high concentrations, but genistein did not affect the antiadrenergic effect of carbachol.	Carbachol	222-231	endothelin 1	Canis lupus familiaris	114-118
15542611-8	2005	Activation of TRPC1 by thapsigargin or carbachol decreased MPP(+) neurotoxicity, which was partially dependent on external Ca(2+).	Carbachol	39-48	transient receptor potential cation channel subfamily C member 1	Homo sapiens	14-19
15358594-8	2005	The pharmacological agonists phorbol 12-myristate 13-acetate and carbachol also led to the translocation of PKC-epsilon.	Carbachol	65-74	protein kinase C epsilon	Homo sapiens	108-119
15358594-10	2005	In response to carbachol, MARCKS translocates to the cytosol, indicating its phosphorylation, which is additionally confirmed biochemically.	Carbachol	15-24	myristoylated alanine rich protein kinase C substrate	Homo sapiens	26-32
15358594-11	2005	Consistent with this observation, carbachol induces the translocation of PKC-epsilon to proximity with MARCKS at the lateral membrane.	Carbachol	34-43	protein kinase C epsilon	Homo sapiens	73-84
15358594-11	2005	Consistent with this observation, carbachol induces the translocation of PKC-epsilon to proximity with MARCKS at the lateral membrane.	Carbachol	34-43	myristoylated alanine rich protein kinase C substrate	Homo sapiens	103-109
15762196-9	2005	RESULTS: Among the various agents inducing H2O2 generation in dog thyrocytes, carbamylcholine is the only one which activates Rac1, whereas phorbol ester and calcium increase alone have no effect, and cAMP inactivates it.	Carbachol	78-93	Rac family small GTPase 1	Canis lupus familiaris	126-130
15637342-5	2005	We have evaluated changes in pancreatic amylase mRNA and total RNA after a single injection of carbachol and under fasting conditions.	Carbachol	95-104	amylase 2a3	Rattus norvegicus	29-47
15998525-6	2005	At network level, 1-5 microM LY354740 significantly reduced the power of gamma frequency oscillations induced by 20 microM carbachol, 600 nM kainate and 5 mM K+ in hippocampal CA1 area.	Carbachol	123-132	carbonic anhydrase 1	Homo sapiens	176-179
15617733-4	2005	It was found that activation of muscarinic acetylcholine receptors (mAChR) (1-10 microM carbachol), inhibited evoked responses across all layers of CA1.	Carbachol	88-97	carbonic anhydrase 1	Homo sapiens	148-151
16125858-7	2005	In addition, patterns of tyrosine kinase receptor and Fos immunoreactivity similar to those observed in nerve growth factor-injected cats were present, in conjunction with long-lasting rapid eye movement sleep, following the microinjection of carbachol into the dorsal pons.	Carbachol	243-252	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	54-57
16125858-7	2005	In addition, patterns of tyrosine kinase receptor and Fos immunoreactivity similar to those observed in nerve growth factor-injected cats were present, in conjunction with long-lasting rapid eye movement sleep, following the microinjection of carbachol into the dorsal pons.	Carbachol	243-252	beta-nerve growth factor	Felis catus	104-123
15636715-10	2005	While in carbachol treatment groups, the levels of TNF-alpha, Cr, ALT, CK-MB in plasma were decreased dramatically after enteral administration of carbachol during ischemia stage.	Carbachol	9-18	tumor necrosis factor	Oryctolagus cuniculus	51-60
15636715-10	2005	While in carbachol treatment groups, the levels of TNF-alpha, Cr, ALT, CK-MB in plasma were decreased dramatically after enteral administration of carbachol during ischemia stage.	Carbachol	147-156	tumor necrosis factor	Oryctolagus cuniculus	51-60
15485827-3	2004	The fragment is able to recognize its receptor on Chinese hamster ovary cells transfected with the M2 muscarinic acetylcholine receptor to block the effect of carbachol on this receptor and to exert an inverse agonist activity on the basal activity of the receptor.	Carbachol	159-168	cholinergic receptor, muscarinic 2	Rattus norvegicus	99-135
15857717-6	2005	Compared with young, the power in the 20-80 Hz frequency range in area CA3 of slices from aged mice was reduced to 14% for kainate-induced oscillations and to 7% for carbachol-induced oscillations, whereas waveform, dominant frequency and coherence of the oscillation were unchanged.	Carbachol	166-175	carbonic anhydrase 3	Mus musculus	71-74
16055947-6	2005	Pretreatment with the caspase inhibitor Boc-Asp-(OMe)-fluoromethylketone (BAF) plus neurotrophin-3 (NT-3) reduced C2- ceramide-induced CAD cell death, delaying cell death more effectively than either agent alone; and, most significantly, BAF and NT-3 enabled the cells remaining 24 h after toxin treatment to generate a normal metabolic response to the muscarinic agonist carbachol.	Carbachol	372-381	neurotrophin 3	Homo sapiens	84-98
16055947-6	2005	Pretreatment with the caspase inhibitor Boc-Asp-(OMe)-fluoromethylketone (BAF) plus neurotrophin-3 (NT-3) reduced C2- ceramide-induced CAD cell death, delaying cell death more effectively than either agent alone; and, most significantly, BAF and NT-3 enabled the cells remaining 24 h after toxin treatment to generate a normal metabolic response to the muscarinic agonist carbachol.	Carbachol	372-381	neurotrophin 3	Homo sapiens	100-104
15317664-5	2004	Whereas carbachol significantly upregulated myosin heavy chain SMA isoform expression in muscle strips held at slack length, carbachol did not significantly alter SMA expression in muscle strips at sinusoidal length oscillation.	Carbachol	8-17	myosin heavy chain 11	Bos taurus	44-66
15317664-5	2004	Whereas carbachol significantly upregulated myosin heavy chain SMA isoform expression in muscle strips held at slack length, carbachol did not significantly alter SMA expression in muscle strips at sinusoidal length oscillation.	Carbachol	8-17	survival of motor neuron 1, telomeric	Bos taurus	63-66
15317664-6	2004	Carbachol also significantly upregulated GAPDH expression in bovine tracheal smooth muscle.	Carbachol	0-9	glyceraldehyde-3-phosphate dehydrogenase	Bos taurus	41-46
15317664-9	2004	U0126 (10 muM) completely inhibited carbachol-induced ERK1/2 MAPK phosphorylation but did not significantly affect carbachol-induced upregulation of GAPDH and SMA expression, suggesting that the ERK1/2 MAPK pathway was not the underlying mechanism.	Carbachol	36-45	mitogen-activated protein kinase 3	Bos taurus	54-60
15317664-9	2004	U0126 (10 muM) completely inhibited carbachol-induced ERK1/2 MAPK phosphorylation but did not significantly affect carbachol-induced upregulation of GAPDH and SMA expression, suggesting that the ERK1/2 MAPK pathway was not the underlying mechanism.	Carbachol	36-45	mitogen-activated protein kinase 1	Bos taurus	61-65
15317664-9	2004	U0126 (10 muM) completely inhibited carbachol-induced ERK1/2 MAPK phosphorylation but did not significantly affect carbachol-induced upregulation of GAPDH and SMA expression, suggesting that the ERK1/2 MAPK pathway was not the underlying mechanism.	Carbachol	36-45	mitogen-activated protein kinase 3	Bos taurus	195-201
15317664-9	2004	U0126 (10 muM) completely inhibited carbachol-induced ERK1/2 MAPK phosphorylation but did not significantly affect carbachol-induced upregulation of GAPDH and SMA expression, suggesting that the ERK1/2 MAPK pathway was not the underlying mechanism.	Carbachol	36-45	mitogen-activated protein kinase 1	Bos taurus	202-206
15588249-7	2004	UII (1 nmol/l) also inhibited the insulin responses induced by carbachol, glucagon-like peptide-1, and a calcium channel agonist (BAY K 8644).	Carbachol	63-72	urotensin 2	Rattus norvegicus	0-3
15579537-2	2004	With nystatin-perforated recording, the magnitude and time courses of activation and inactivation of carbachol (CCh; 100 microM)-activated TRPC6 currents (I(TRPC6)) were enhanced and accelerated, respectively, by extracellular Ca2+ (Ca2+(o)) whether it was continuously present or applied after receptor stimulation.	Carbachol	101-110	transient receptor potential cation channel subfamily C member 6	Homo sapiens	139-144
15579537-2	2004	With nystatin-perforated recording, the magnitude and time courses of activation and inactivation of carbachol (CCh; 100 microM)-activated TRPC6 currents (I(TRPC6)) were enhanced and accelerated, respectively, by extracellular Ca2+ (Ca2+(o)) whether it was continuously present or applied after receptor stimulation.	Carbachol	101-110	transient receptor potential cation channel subfamily C member 6	Homo sapiens	157-162
15579537-2	2004	With nystatin-perforated recording, the magnitude and time courses of activation and inactivation of carbachol (CCh; 100 microM)-activated TRPC6 currents (I(TRPC6)) were enhanced and accelerated, respectively, by extracellular Ca2+ (Ca2+(o)) whether it was continuously present or applied after receptor stimulation.	Carbachol	112-115	transient receptor potential cation channel subfamily C member 6	Homo sapiens	139-144
15579537-2	2004	With nystatin-perforated recording, the magnitude and time courses of activation and inactivation of carbachol (CCh; 100 microM)-activated TRPC6 currents (I(TRPC6)) were enhanced and accelerated, respectively, by extracellular Ca2+ (Ca2+(o)) whether it was continuously present or applied after receptor stimulation.	Carbachol	112-115	transient receptor potential cation channel subfamily C member 6	Homo sapiens	157-162
15579537-8	2004	Instead, single CCh-activated TRPC7 channel activity was concentration-dependently suppressed by nanomolar Ca2+(i) via CaM and conversely enhanced by IP3.	Carbachol	16-19	transient receptor potential cation channel subfamily C member 7	Homo sapiens	30-35
15613736-3	2004	The muscarinic agent - carbachol-induced HPA response was considerably supressed by piroxicam, a predominantly constitutive cyclooxygenase (COX-1) inhibitor and significantly diminished by indomethacin, a non-selective COX blocker, but was unaffected by compound NS-398, an inducible cyclooxygenase (COX-2) antagonist.	Carbachol	23-32	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	140-145
15518913-1	2004	A novel VIP derivative, [R15, 20, 21, L17]-VIP-GRR (IK312532), relaxed potently the carbachol-induced contraction of guinea-pig isolated trachea with longer duration than that induced by VIP.	Carbachol	84-93	vasoactive intestinal peptide	Rattus norvegicus	8-11
15518913-1	2004	A novel VIP derivative, [R15, 20, 21, L17]-VIP-GRR (IK312532), relaxed potently the carbachol-induced contraction of guinea-pig isolated trachea with longer duration than that induced by VIP.	Carbachol	84-93	vasoactive intestinal peptide	Rattus norvegicus	43-46
15518913-1	2004	A novel VIP derivative, [R15, 20, 21, L17]-VIP-GRR (IK312532), relaxed potently the carbachol-induced contraction of guinea-pig isolated trachea with longer duration than that induced by VIP.	Carbachol	84-93	VIP peptides	Cavia porcellus	43-46
15380628-6	2004	A 60-75% decline in contractility was observed when Cav1 knockout muscle strips were stimulated with electric current or carbachol, compared to wildtype muscle strips.	Carbachol	121-130	caveolin 1, caveolae protein	Mus musculus	52-56
15742997-7	2004	The effects of ghrelin on spontaneous contractile activities of isolated strips from stomach and jejunum were also investigated and the influence of ghrelin on motor responses to carbachol and electrical field stimulation was examined.	Carbachol	179-188	ghrelin and obestatin prepropeptide	Rattus norvegicus	149-156
15269004-5	2004	Carbachol induced ERK1/2 phosphorylation by 300% of basal value.	Carbachol	0-9	mitogen-activated protein kinase 3	Bos taurus	18-24
15269004-6	2004	U0126 (10 microM) completely inhibited carbachol-induced ERK1/2 phosphorylation but did not significantly affect the correlation between alpha-actinin P/S and carbachol concentration.	Carbachol	39-48	mitogen-activated protein kinase 3	Bos taurus	57-63
15613736-3	2004	The muscarinic agent - carbachol-induced HPA response was considerably supressed by piroxicam, a predominantly constitutive cyclooxygenase (COX-1) inhibitor and significantly diminished by indomethacin, a non-selective COX blocker, but was unaffected by compound NS-398, an inducible cyclooxygenase (COX-2) antagonist.	Carbachol	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	300-305
15500825-6	2004	Overnight stimulation of primary cultured rabbit lacrimal gland acinar cells with 10 microM carbachol (CCh) significantly decreased the abundance of mature cathepsin B in the pre-lysosome and lysosome; decreased the abundance of preprocathepsin B in fractions containing the TGN and late endosome; increased the abundance of procathepsin B in fractions containing the basal-lateral membrane; and increased the accumulation of endocytosed [(125)I]-EGF in the recycling endosome.	Carbachol	92-101	cathepsin B	Oryctolagus cuniculus	156-167
15500825-6	2004	Overnight stimulation of primary cultured rabbit lacrimal gland acinar cells with 10 microM carbachol (CCh) significantly decreased the abundance of mature cathepsin B in the pre-lysosome and lysosome; decreased the abundance of preprocathepsin B in fractions containing the TGN and late endosome; increased the abundance of procathepsin B in fractions containing the basal-lateral membrane; and increased the accumulation of endocytosed [(125)I]-EGF in the recycling endosome.	Carbachol	103-106	cathepsin B	Oryctolagus cuniculus	156-167
15485492-7	2004	Moreover, cholinergic stimulation of neuroblastoma cells by carbachol, which activated endogenous Ras/ERK1/2, induced a significant increase in ROS levels and elicited membrane translocation of p67(phox) and Rac.	Carbachol	60-69	mitogen-activated protein kinase 3	Homo sapiens	102-108
15485492-7	2004	Moreover, cholinergic stimulation of neuroblastoma cells by carbachol, which activated endogenous Ras/ERK1/2, induced a significant increase in ROS levels and elicited membrane translocation of p67(phox) and Rac.	Carbachol	60-69	CD33 molecule	Homo sapiens	194-197
15485492-7	2004	Moreover, cholinergic stimulation of neuroblastoma cells by carbachol, which activated endogenous Ras/ERK1/2, induced a significant increase in ROS levels and elicited membrane translocation of p67(phox) and Rac.	Carbachol	60-69	AKT serine/threonine kinase 1	Homo sapiens	208-211
15485492-8	2004	ROS generation induced by carbachol required the activation of ERK1/2 and PI3K.	Carbachol	26-35	mitogen-activated protein kinase 3	Homo sapiens	63-69
15502635-5	2004	Glucose-induced Crk-p130Cas association was rapid and sustained and was maximal with the combination of glucose and carbachol, paralleling insulin secretion.	Carbachol	116-125	CRK proto-oncogene, adaptor protein	Rattus norvegicus	16-19
15514253-9	2004	In colon, there was a change of sensitivity (50% effective concentration) to angiotensin II in WKY (P &lt; 0.05) due to increased SF and a change of sensitivity to prostaglandin (PG)E(2) and carbachol in SHR (P &lt; 0.05).	Carbachol	191-200	angiotensinogen	Rattus norvegicus	77-91
15502635-5	2004	Glucose-induced Crk-p130Cas association was rapid and sustained and was maximal with the combination of glucose and carbachol, paralleling insulin secretion.	Carbachol	116-125	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	20-27
15467192-0	2004	Carbachol-induced membrane ruffling and its desensitization in rat basophilic leukemia (RBL-2H3) cells transfected with m3 muscarinic acetylcholine receptors.	Carbachol	0-9	cholinergic receptor muscarinic 3	Homo sapiens	120-157
15483626-5	2004	Carbachol- and phenylephrine-contracted smooth muscle strips from colon and aorta, respectively, of IRAG(Delta12/Delta12) mice were not relaxed by cGMP, while cAMP-mediated relaxation was unperturbed.	Carbachol	0-9	inositol 1,4,5-triphosphate receptor associated 1	Mus musculus	100-104
15217780-1	2004	PKC is known to be activated by pancreatic secretagogues such as CCK and carbachol and to participate along with calcium in amylase release.	Carbachol	73-82	protein kinase C, alpha	Rattus norvegicus	0-3
15371786-11	2004	Similarly, bladders from SMalphaA-null mice generated less force than wild-type mice in response to pretreatment EFS, and EFS after carbachol and atropine, although the difference was not significant.	Carbachol	132-141	actin alpha 2, smooth muscle, aorta	Mus musculus	25-33
15277524-1	2004	We have seen that protein kinase Calpha (PKCalpha) is transiently translocated to the plasma membrane by carbachol stimulation of neuroblastoma cells.	Carbachol	105-114	protein kinase C alpha	Homo sapiens	18-39
15190096-5	2004	In contrast, just two suprathreshold stimuli &gt;50 Hz triggered a prominent sAHP sensitive to bath-applications of isoproterenol, carbachol, or intracellularly applied BAPTA, suggesting that the underlying current is the Ca2+-activated K+ current, the sIAHP.	Carbachol	131-140	carbonic anhydrase 2	Rattus norvegicus	222-225
15277524-1	2004	We have seen that protein kinase Calpha (PKCalpha) is transiently translocated to the plasma membrane by carbachol stimulation of neuroblastoma cells.	Carbachol	105-114	protein kinase C alpha	Homo sapiens	41-49
15277524-6	2004	Carbachol stimulation induced a transient translocation of PKCalpha to the plasma membrane and a sustained translocation of kinase-dead PKCalpha.	Carbachol	0-9	protein kinase C alpha	Homo sapiens	59-67
15277524-6	2004	Carbachol stimulation induced a transient translocation of PKCalpha to the plasma membrane and a sustained translocation of kinase-dead PKCalpha.	Carbachol	0-9	protein kinase C alpha	Homo sapiens	136-144
15275856-8	2004	Amylase release stimulated by carbachol and GSNO was inhibited by addition of the sGC inhibitor, ODQ, and cGMP-dependent protein kinase inhibitor, KT-5823.	Carbachol	30-39	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	82-85
15359086-1	2004	Carbachol (CCh) caused a dose-dependent release of beta-hexosaminidase and an increase in the production of inositol 1,4,5-trisphosphate (IP3) in RBL-2H3 cells transfected with m2 mAChR cDNA (RBL-m2 cells).	Carbachol	0-9	O-GlcNAcase	Rattus norvegicus	51-70
15359086-1	2004	Carbachol (CCh) caused a dose-dependent release of beta-hexosaminidase and an increase in the production of inositol 1,4,5-trisphosphate (IP3) in RBL-2H3 cells transfected with m2 mAChR cDNA (RBL-m2 cells).	Carbachol	11-14	O-GlcNAcase	Rattus norvegicus	51-70
15322258-5	2004	These AChE inhibitors had no significant effect on either the amplitude or kinetics of alpha7 nAChRs activated by ACh, but they slowed the rate of recovery from desensitization through an indirect mechanism; responses activated with either choline or carbachol were unaffected.	Carbachol	251-260	acetylcholinesterase	Rattus norvegicus	6-10
15272012-6	2004	In 1321N1 human astrocytoma cells, the endogenous PDE1 (identified as PDE1A by reverse transcriptase-PCR) was largely insensitive to Ca2+ released from carbachol-sensitive stores but was robustly stimulated by a similar rise in [Ca2+]i due to carbachol-induced Ca2+ influx.	Carbachol	152-161	phosphodiesterase 1A	Homo sapiens	70-75
15272012-6	2004	In 1321N1 human astrocytoma cells, the endogenous PDE1 (identified as PDE1A by reverse transcriptase-PCR) was largely insensitive to Ca2+ released from carbachol-sensitive stores but was robustly stimulated by a similar rise in [Ca2+]i due to carbachol-induced Ca2+ influx.	Carbachol	243-252	phosphodiesterase 1A	Homo sapiens	70-75
15279909-7	2004	We also found a marked decrease on Cch-stimulated Ca2+ mobilization in pretreated FRT cells with forskolin, an activator of protein kinase A (PKA), but the preincubation of cells with genistein, an inhibitor of protein tyrosine kinases, had no effect on Ca2+ mobilization induced by Cch.	Carbachol	35-38	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	124-140
15279909-7	2004	We also found a marked decrease on Cch-stimulated Ca2+ mobilization in pretreated FRT cells with forskolin, an activator of protein kinase A (PKA), but the preincubation of cells with genistein, an inhibitor of protein tyrosine kinases, had no effect on Ca2+ mobilization induced by Cch.	Carbachol	35-38	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	142-145
15327778-8	2004	Importantly, carbachol, not thapsigargin, increased surface expression of TRPC3 that was attenuated by TeNT and not by BAPTA.	Carbachol	13-22	transient receptor potential cation channel subfamily C member 3	Homo sapiens	74-79
15327778-9	2004	In aggregate, these data suggest that VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to carbachol-stimulation of Ca2+ influx.	Carbachol	138-147	vesicle associated membrane protein 2	Homo sapiens	38-43
15264218-3	2004	Histamine, glutamate, carbachol, serotonin or gamma-aminobutyric acid (GABA) caused an increase of FGF-1 content.	Carbachol	22-31	fibroblast growth factor 1	Rattus norvegicus	99-104
15287742-8	2004	BC3H1 cells containing a fetal mouse muscle-type nAChR were used, and the receptor was activated by carbamoylcholine.	Carbachol	100-116	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	49-54
15287742-11	2004	Inhibitors and compounds that alleviate inhibition were tested by determining their effects on the whole-cell current due to activation of the nAChR by carbamoylcholine.	Carbachol	152-168	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	143-148
15242775-3	2004	Overexpression of Bcl-2 inhibited carbachol-induced ROCK-I cleavage, indicating a mitochondrial apoptotic pathway.	Carbachol	34-43	BCL2 apoptosis regulator	Homo sapiens	18-23
15242775-3	2004	Overexpression of Bcl-2 inhibited carbachol-induced ROCK-I cleavage, indicating a mitochondrial apoptotic pathway.	Carbachol	34-43	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	52-58
15242775-5	2004	Insulin, a major survival factor in many cells, strongly increased phosphorylation of Akt, which was completely blocked by carbachol.	Carbachol	123-132	insulin	Homo sapiens	0-7
15242775-5	2004	Insulin, a major survival factor in many cells, strongly increased phosphorylation of Akt, which was completely blocked by carbachol.	Carbachol	123-132	AKT serine/threonine kinase 1	Homo sapiens	86-89
15242775-7	2004	In parallel with these observations, carbachol attenuated insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1, an effect eliminated by orthovanadate.	Carbachol	37-46	insulin	Homo sapiens	58-65
15242775-7	2004	In parallel with these observations, carbachol attenuated insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1, an effect eliminated by orthovanadate.	Carbachol	37-46	insulin	Homo sapiens	105-112
15242775-8	2004	On the other hand, carbachol induced rapid stimulation of endogenous RhoA, and expression of a constitutively active mutant of RhoA increased ROCK-I cleavage.	Carbachol	19-28	ras homolog family member A	Homo sapiens	69-73
15242775-8	2004	On the other hand, carbachol induced rapid stimulation of endogenous RhoA, and expression of a constitutively active mutant of RhoA increased ROCK-I cleavage.	Carbachol	19-28	ras homolog family member A	Homo sapiens	127-131
15242775-8	2004	On the other hand, carbachol induced rapid stimulation of endogenous RhoA, and expression of a constitutively active mutant of RhoA increased ROCK-I cleavage.	Carbachol	19-28	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	142-148
15242775-9	2004	Orthovanadate and the dominant negative mutant of RhoA partially, and their combination completely, inhibited carbachol-induced ROCK-I cleavage and apoptosis.	Carbachol	110-119	ras homolog family member A	Homo sapiens	50-54
15242775-9	2004	Orthovanadate and the dominant negative mutant of RhoA partially, and their combination completely, inhibited carbachol-induced ROCK-I cleavage and apoptosis.	Carbachol	110-119	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	128-134
15286428-2	2004	Among the CHO-H1/M1, CHO-H1/M3, and CHO-H1/M5 cells, carbachol treatment of the CHO-H1/M3 cells time-dependently led to remarkable down-regulation of the H1R to 60% of the control level.	Carbachol	53-62	histamine receptor H1	Homo sapiens	154-157
15286428-4	2004	Stimulation of CHO-H1/M5 cells by carbachol induced significant but only small H1R down-regulation.	Carbachol	34-43	histamine receptor H1	Homo sapiens	79-82
15286428-6	2004	H1R-mediated accumulation of inositol phosphates in CHO-H1/M3 cells with long-term expose to carbachol was decreased to 60% compared with non-treated cells.	Carbachol	93-102	histamine receptor H1	Homo sapiens	0-3
15233804-5	2004	Treatment of PKCalpha-deficient cells with carbachol induced a significant release of sAPPalpha.	Carbachol	43-52	protein kinase C alpha	Homo sapiens	13-21
15233804-7	2004	The response to carbachol is instead completely blocked in PKCepsilon-deficient cells suggesting the importance of PKCepsilon in coupling cholinergic receptors with APP metabolism.	Carbachol	16-25	protein kinase C epsilon	Homo sapiens	59-69
15087463-4	2004	Cellular PLD activity was increased in response to a variety of secretagogues including the nutrient glucose and the cholinergic receptor agonist carbamoylcholine.	Carbachol	146-162	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	9-12
15182196-3	2004	In co-immunoprecipitation studies, both glutamate and carbachol increased the association of GRK2 with mGluR1a.	Carbachol	54-63	G protein-coupled receptor kinase 2	Homo sapiens	93-97
15182196-4	2004	Co-addition of the protein kinase C (PKC) inhibitor GF109203X and the Ca(2+) calmodulin-dependent kinase II (CaMKII) inhibitor KN-93 blocked the ability of glutamate and carbachol to increase the association of GRK2 with mGluR1a.	Carbachol	170-179	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	109-115
15182196-8	2004	The carbachol-induced heterologous desensitization and internalization of mGluR1a was blocked by LY367385, an mGluR1a antagonist with inverse agonist activity.	Carbachol	4-13	glutamate metabotropic receptor 1	Homo sapiens	74-80
15182196-8	2004	The carbachol-induced heterologous desensitization and internalization of mGluR1a was blocked by LY367385, an mGluR1a antagonist with inverse agonist activity.	Carbachol	4-13	glutamate metabotropic receptor 1	Homo sapiens	110-116
15272012-7	2004	Gd3+, which effectively blocked thapsigargin-induced CCE and its effect on PDE1A, also inhibited the activation of PDE1A by carbachol-induced Ca2+ entry.	Carbachol	124-133	phosphodiesterase 1A	Homo sapiens	115-120
15255942-0	2004	Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells.	Carbachol	67-76	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	8-23
15255942-4	2004	1-Butanol, which is a substrate for PLD and inhibits PA formation, inhibited carbachol-induced cell proliferation and the underlying intracellular signaling, whereas its analog tert-butanol, which is a poor substrate for PLD, was much less effective.	Carbachol	77-86	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	36-39
15255942-7	2004	Taken together, these results indicate that PLD activation plays an important role in carbachol-induced astroglial cell proliferation by generating the second messenger PA, which activates PKC zeta.	Carbachol	86-95	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	44-47
15255942-7	2004	Taken together, these results indicate that PLD activation plays an important role in carbachol-induced astroglial cell proliferation by generating the second messenger PA, which activates PKC zeta.	Carbachol	86-95	protein kinase C zeta	Homo sapiens	189-197
15255942-8	2004	Moreover, the effect of ethanol on carbachol-induced proliferation appears to be mediated, at least in part, by its ability to interact with PLD leading to a decreased synthesis of PA.	Carbachol	35-44	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	141-144
15247775-9	2004	CONCLUSIONS: These results indicate that in human UBSM CCh induces contraction, not only by increasing [Ca2+]i, but also by increasing the Ca2+ sensitivity of the contractile apparatus in a ROCK and protein kinase C dependent manner.	Carbachol	55-58	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	190-194
15150258-4	2004	However, activation of ERK by epidermal growth factor or carbachol were not suppressed by inhibition of CaMKK, indicating specificity for this "cross-talk."	Carbachol	57-66	mitogen-activated protein kinase 1	Homo sapiens	23-26
15029229-7	2004	In acini exposed to replication-defective or UV-inactivated Ad, carbachol-stimulated release of bulk protein and beta-hexosaminidase were significantly (P&lt; or =0.05) inhibited to an extent proportional to the loss of rab3D-enriched mature secretory vesicles associated with these treatments.	Carbachol	64-73	ras-related protein Rab-3D	Oryctolagus cuniculus	220-225
15155843-4	2004	The heterologous internalization of the mGluR1 splice variants triggered by carbachol was also inhibited by isoprenaline and forskolin in a PKA-sensitive fashion, whereas the constitutive (agonist-independent) internalization of mGluR1a was inhibited only modestly by PKA activation.	Carbachol	76-85	glutamate metabotropic receptor 1	Homo sapiens	40-46
15023993-2	2004	Whole cell membrane currents with distinctive inward and outward rectification were activated by carbachol (CCh) in TRPC6-expressing cells, but not in lacZ-transfected controls.	Carbachol	97-106	transient receptor potential cation channel subfamily C member 6	Homo sapiens	116-121
15182196-9	2004	Furthermore, LY367385 blocked the ability of carbachol to increase the association of GRK2 with mGluR1a.	Carbachol	45-54	G protein-coupled receptor kinase 2	Homo sapiens	86-90
15023993-2	2004	Whole cell membrane currents with distinctive inward and outward rectification were activated by carbachol (CCh) in TRPC6-expressing cells, but not in lacZ-transfected controls.	Carbachol	108-111	transient receptor potential cation channel subfamily C member 6	Homo sapiens	116-121
15023993-9	2004	Surprisingly, concentrations of CCh that produced little or no response in the absence of OAG, produced increases in TRPC6 currents in the presence of OAG that were larger than the sum of either agent alone.	Carbachol	32-35	transient receptor potential cation channel subfamily C member 6	Homo sapiens	117-122
15023993-12	2004	This synergy may explain, at least in part, the steep dose-response relationship observed for CCh-induced TRPC6 currents expressed in HEK cells.	Carbachol	94-97	transient receptor potential cation channel subfamily C member 6	Homo sapiens	106-111
15059931-7	2004	Treatment with TGF-beta also induces a contractile phenotype that responds to the muscarinic agonist carbachol and is not immediately reversed on TGF-beta withdrawal.	Carbachol	101-110	transforming growth factor beta 1	Homo sapiens	15-23
15086448-5	2004	The depolarization evoked by carbachol (50 microm) was potentiated from 5.2 +/- 0.7 mV (n = 6) in control neurones to 27.5 +/- 2.0 mV (n = 10) in TNF-alpha-treated cells.	Carbachol	29-38	tumor necrosis factor	Rattus norvegicus	146-155
14978207-0	2004	Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent.	Carbachol	0-9	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	50-68
14769130-4	2004	However, the effects of carbachol were prevented by sodium vanadate, a protein tyrosine phosphatase inhibitor, and were accompanied by reduced insulin-stimulated IRS-1 tyrosine phosphorylation and recruitment of the 85 kDa regulatory subunit of PI3K to IRS-1, but not by reduced IGF-1 receptor kinase activity.	Carbachol	24-33	insulin receptor substrate 1	Homo sapiens	162-167
14769130-4	2004	However, the effects of carbachol were prevented by sodium vanadate, a protein tyrosine phosphatase inhibitor, and were accompanied by reduced insulin-stimulated IRS-1 tyrosine phosphorylation and recruitment of the 85 kDa regulatory subunit of PI3K to IRS-1, but not by reduced IGF-1 receptor kinase activity.	Carbachol	24-33	insulin receptor substrate 1	Homo sapiens	253-258
14769130-4	2004	However, the effects of carbachol were prevented by sodium vanadate, a protein tyrosine phosphatase inhibitor, and were accompanied by reduced insulin-stimulated IRS-1 tyrosine phosphorylation and recruitment of the 85 kDa regulatory subunit of PI3K to IRS-1, but not by reduced IGF-1 receptor kinase activity.	Carbachol	24-33	insulin like growth factor 1	Homo sapiens	279-284
14769130-5	2004	The inhibitory effect of carbachol was reproduced by okadaic acid, a protein serine/threonine phosphatase inhibitor, but not by PDGF, yet all three agents stimulated the serine phosphorylation of IRS-1 at residues Ser312, Ser616 and Ser636/639, albeit to different extents.	Carbachol	25-34	insulin receptor substrate 1	Homo sapiens	196-201
14978207-11	2004	Moreover, Src was involved in the carbachol-mediated inhibition since: (1) c-Src was rapidly activated in the detergent-resistant membranes by carbachol; and (2) carbachol inhibition of ileal Na(+) absorption was completely abolished by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).	Carbachol	143-152	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	77-80
14978207-11	2004	Moreover, Src was involved in the carbachol-mediated inhibition since: (1) c-Src was rapidly activated in the detergent-resistant membranes by carbachol; and (2) carbachol inhibition of ileal Na(+) absorption was completely abolished by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).	Carbachol	143-152	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	10-13
14978207-11	2004	Moreover, Src was involved in the carbachol-mediated inhibition since: (1) c-Src was rapidly activated in the detergent-resistant membranes by carbachol; and (2) carbachol inhibition of ileal Na(+) absorption was completely abolished by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).	Carbachol	143-152	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	77-80
14978207-11	2004	Moreover, Src was involved in the carbachol-mediated inhibition since: (1) c-Src was rapidly activated in the detergent-resistant membranes by carbachol; and (2) carbachol inhibition of ileal Na(+) absorption was completely abolished by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).	Carbachol	143-152	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	77-80
14978207-0	2004	Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent.	Carbachol	0-9	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	70-74
14978207-0	2004	Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent.	Carbachol	0-9	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	102-106
14978207-0	2004	Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent.	Carbachol	0-9	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	148-151
14978207-12	2004	Moreover, the carbachol-induced increase in the size of NHE3-containing complexes was reversed by PP2.	Carbachol	14-23	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	56-60
14978207-2	2004	We have previously shown that ileal BBM NHE3 activity is rapidly inhibited by carbachol, an agonist that mimics cholinergic activation in digestion.	Carbachol	78-87	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	40-44
14978207-14	2004	The study further describes NHE3 presence simultaneously in multiple dynamic BBM pools in which NHE3 distribution and associated proteins are altered as part of carbachol-induced and Src-mediated rapid signal transduction, which decreases the amount of BBM NHE3 and thus inhibits NHE3 activity.	Carbachol	161-170	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	28-32
14978207-4	2004	Carbachol decreased the amount of ileal Na(+) absorptive cell BBM NHE3 within 10 min of exposure.	Carbachol	0-9	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	66-70
14978207-14	2004	The study further describes NHE3 presence simultaneously in multiple dynamic BBM pools in which NHE3 distribution and associated proteins are altered as part of carbachol-induced and Src-mediated rapid signal transduction, which decreases the amount of BBM NHE3 and thus inhibits NHE3 activity.	Carbachol	161-170	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	96-100
14978207-5	2004	Based on OptiPrep gradient centrifugation, carbachol increased the amount of NHE3 in early endosomes and decreased the amount of NHE3 in BBM, consistent with effects on NHE3 trafficking.	Carbachol	43-52	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	77-81
14978207-14	2004	The study further describes NHE3 presence simultaneously in multiple dynamic BBM pools in which NHE3 distribution and associated proteins are altered as part of carbachol-induced and Src-mediated rapid signal transduction, which decreases the amount of BBM NHE3 and thus inhibits NHE3 activity.	Carbachol	161-170	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	183-186
14978207-14	2004	The study further describes NHE3 presence simultaneously in multiple dynamic BBM pools in which NHE3 distribution and associated proteins are altered as part of carbachol-induced and Src-mediated rapid signal transduction, which decreases the amount of BBM NHE3 and thus inhibits NHE3 activity.	Carbachol	161-170	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	96-100
14978207-5	2004	Based on OptiPrep gradient centrifugation, carbachol increased the amount of NHE3 in early endosomes and decreased the amount of NHE3 in BBM, consistent with effects on NHE3 trafficking.	Carbachol	43-52	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	129-133
14978207-14	2004	The study further describes NHE3 presence simultaneously in multiple dynamic BBM pools in which NHE3 distribution and associated proteins are altered as part of carbachol-induced and Src-mediated rapid signal transduction, which decreases the amount of BBM NHE3 and thus inhibits NHE3 activity.	Carbachol	161-170	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	96-100
14978207-5	2004	Based on OptiPrep gradient centrifugation, carbachol increased the amount of NHE3 in early endosomes and decreased the amount of NHE3 in BBM, consistent with effects on NHE3 trafficking.	Carbachol	43-52	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	129-133
14978207-7	2004	The size of BBM NHE3 complexes increased in carbachol-exposed ileum, as studied with sucrose gradient centrifugation.	Carbachol	44-53	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	16-20
14978207-9	2004	This suggests that carbachol treatment enhanced the association of proteins with NHE3 complexes specifically in the detergent-resistant fraction of ileal BBM.	Carbachol	19-28	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	81-85
14978207-10	2004	NHERF2, alpha-actinin-4 and protein kinase C were among those NHE3-associated proteins because they were more efficiently coimmunoprecipitated from total BBM after carbachol treatment.	Carbachol	164-173	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	62-66
14978207-11	2004	Moreover, Src was involved in the carbachol-mediated inhibition since: (1) c-Src was rapidly activated in the detergent-resistant membranes by carbachol; and (2) carbachol inhibition of ileal Na(+) absorption was completely abolished by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).	Carbachol	34-43	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	10-13
14978207-11	2004	Moreover, Src was involved in the carbachol-mediated inhibition since: (1) c-Src was rapidly activated in the detergent-resistant membranes by carbachol; and (2) carbachol inhibition of ileal Na(+) absorption was completely abolished by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).	Carbachol	34-43	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	77-80
14978207-11	2004	Moreover, Src was involved in the carbachol-mediated inhibition since: (1) c-Src was rapidly activated in the detergent-resistant membranes by carbachol; and (2) carbachol inhibition of ileal Na(+) absorption was completely abolished by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).	Carbachol	34-43	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	77-80
14978207-11	2004	Moreover, Src was involved in the carbachol-mediated inhibition since: (1) c-Src was rapidly activated in the detergent-resistant membranes by carbachol; and (2) carbachol inhibition of ileal Na(+) absorption was completely abolished by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).	Carbachol	143-152	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	10-13
14978207-11	2004	Moreover, Src was involved in the carbachol-mediated inhibition since: (1) c-Src was rapidly activated in the detergent-resistant membranes by carbachol; and (2) carbachol inhibition of ileal Na(+) absorption was completely abolished by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).	Carbachol	143-152	proto-oncogene tyrosine-protein kinase Src	Oryctolagus cuniculus	77-80
15020229-5	2004	Glutamate was a potent activator of PLD in neurons but not in astrocytes, whereas noradrenaline and carbachol increased PLD activity only in astrocytes.	Carbachol	100-109	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	120-123
15023564-12	2004	They also displayed a carbachol-induced contractility in a medium containing IGF1.	Carbachol	22-31	insulin like growth factor 1	Homo sapiens	77-81
15048931-10	2004	Carbachol also increased BDNF mRNA levels without changing NGF or NT(3).	Carbachol	0-9	brain derived neurotrophic factor	Homo sapiens	25-29
14752030-8	2004	ISO-activated systolic function was inhibited 85% by concomitant muscarinic stimulation (carbachol) in NOS3(-/-)+AdV(NOS3) but not NOS3(-/-)+AdVbeta(gal) hearts.	Carbachol	89-98	nitric oxide synthase 3, endothelial cell	Mus musculus	103-107
14736881-3	2004	Ca(2+) signals generated by TRPC3 overexpression in HEK293 cells were found to be dependent on extracellular Na(+), in that carbachol-stimulated Ca(2+) entry into TRPC3 expressing cells was significantly suppressed when extracellular Na(+) was reduced to 5 mm.	Carbachol	124-133	transient receptor potential cation channel subfamily C member 3	Homo sapiens	28-33
14736881-3	2004	Ca(2+) signals generated by TRPC3 overexpression in HEK293 cells were found to be dependent on extracellular Na(+), in that carbachol-stimulated Ca(2+) entry into TRPC3 expressing cells was significantly suppressed when extracellular Na(+) was reduced to 5 mm.	Carbachol	124-133	transient receptor potential cation channel subfamily C member 3	Homo sapiens	163-168
14736881-6	2004	Similar rises in Ca(2+)(i) were recorded in TRPC3-overexpressing cells upon the reduction of extracellular Na(+) subsequent to stimulation with carbachol.	Carbachol	144-153	transient receptor potential cation channel subfamily C member 3	Homo sapiens	44-49
14988028-1	2004	An earlier study showed that the neuropeptide Y (NPY) receptor antagonist PYX-2 blocks the enhancement of a carbachol (CCh)-evoked pressor response produced by prior NPY administration into the posterior hypothalamic nucleus (PHN).	Carbachol	108-117	neuropeptide Y	Rattus norvegicus	49-52
14988028-1	2004	An earlier study showed that the neuropeptide Y (NPY) receptor antagonist PYX-2 blocks the enhancement of a carbachol (CCh)-evoked pressor response produced by prior NPY administration into the posterior hypothalamic nucleus (PHN).	Carbachol	108-117	neuropeptide Y	Rattus norvegicus	166-169
14988028-1	2004	An earlier study showed that the neuropeptide Y (NPY) receptor antagonist PYX-2 blocks the enhancement of a carbachol (CCh)-evoked pressor response produced by prior NPY administration into the posterior hypothalamic nucleus (PHN).	Carbachol	119-122	neuropeptide Y	Rattus norvegicus	49-52
14988028-1	2004	An earlier study showed that the neuropeptide Y (NPY) receptor antagonist PYX-2 blocks the enhancement of a carbachol (CCh)-evoked pressor response produced by prior NPY administration into the posterior hypothalamic nucleus (PHN).	Carbachol	119-122	neuropeptide Y	Rattus norvegicus	166-169
14724209-4	2004	An analysis of mutant channels expressed in Xenopus oocytes revealed two amino acid substitutions in the C-terminal domain of GIRK2, GIRK2(L344E) and GIRK2(G347H), that exhibited decreased carbachol-activated currents but significantly enhanced basal currents with coexpression of G(betagamma) subunits.	Carbachol	189-198	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	126-131
14724209-4	2004	An analysis of mutant channels expressed in Xenopus oocytes revealed two amino acid substitutions in the C-terminal domain of GIRK2, GIRK2(L344E) and GIRK2(G347H), that exhibited decreased carbachol-activated currents but significantly enhanced basal currents with coexpression of G(betagamma) subunits.	Carbachol	189-198	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	133-138
14724209-4	2004	An analysis of mutant channels expressed in Xenopus oocytes revealed two amino acid substitutions in the C-terminal domain of GIRK2, GIRK2(L344E) and GIRK2(G347H), that exhibited decreased carbachol-activated currents but significantly enhanced basal currents with coexpression of G(betagamma) subunits.	Carbachol	189-198	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	133-138
14724209-5	2004	Combining the two mutations (GIRK2(EH)) led to a more severe reduction in carbachol-activated and G(betagamma)-stimulated currents.	Carbachol	74-83	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	29-34
14724209-7	2004	Both GIRK2(L344E) and GIRK2(EH) also showed reduced carbachol activation and normal ethanol activation when expressed in HEK-293T cells.	Carbachol	52-61	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	5-10
14724209-7	2004	Both GIRK2(L344E) and GIRK2(EH) also showed reduced carbachol activation and normal ethanol activation when expressed in HEK-293T cells.	Carbachol	52-61	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	22-27
15196660-3	2004	Time course studies revealed peak translocation after 40 min incubation with carbachol for PKCgamma (110% increase from basal, i.e. no carbachol level, P &lt; 0.01), 30 min for phosphorylated PKCbetaII (130%, P &lt; 0.05) and 5 min for non-phosphorylated PKCbetaII (64%, P &lt; 0.05) with no peak for alpha.	Carbachol	77-86	protein kinase C, gamma	Mus musculus	91-99
15023776-6	2004	Carbachol caused an elevation of the relative amount of E-cadherin in keratinocytes (P&lt;.05) without changing that of plakoglobin (P&gt;.05).	Carbachol	0-9	cadherin 1	Homo sapiens	56-66
15023776-7	2004	The phosphorylation level of E-cadherin and plakoglobin was increased by PV IgG, whereas this effect of PV IgG was attenuated in the presence of 0.5mM carbachol.	Carbachol	151-160	cadherin 1	Homo sapiens	29-39
15152572-0	2004	[Carbachol effect on kinetics of the alpha1-adrenergic contractile response of the rat vas deferens].	Carbachol	1-10	arginine vasopressin	Rattus norvegicus	87-90
14662757-7	2004	The carbachol concentration at which TRPC6 externalization occurred was lower than the concentration required to activate TRPC6.	Carbachol	4-13	transient receptor potential cation channel subfamily C member 6	Homo sapiens	37-42
14662757-7	2004	The carbachol concentration at which TRPC6 externalization occurred was lower than the concentration required to activate TRPC6.	Carbachol	4-13	transient receptor potential cation channel subfamily C member 6	Homo sapiens	122-127
14706287-2	2004	We have shown that RNAi knock down of either the inositol 1,4,5-trisphosphate receptor (Ins(1,4,5)P(3)R), or the SERCA calcium pump in the S2-DM1 cells blocks the increase in intracellular calcium concentration ([Ca(2+)](i)) resulting from activation of the DM1 receptor by 100 microM carbamylcholine (CCh).	Carbachol	285-300	muscarinic Acetylcholine Receptor, A-type	Drosophila melanogaster	142-145
14706287-2	2004	We have shown that RNAi knock down of either the inositol 1,4,5-trisphosphate receptor (Ins(1,4,5)P(3)R), or the SERCA calcium pump in the S2-DM1 cells blocks the increase in intracellular calcium concentration ([Ca(2+)](i)) resulting from activation of the DM1 receptor by 100 microM carbamylcholine (CCh).	Carbachol	302-305	muscarinic Acetylcholine Receptor, A-type	Drosophila melanogaster	142-145
14729360-3	2004	The aim of this study was to determine the agonist activity of PGF2alpha, latanoprost and carbachol (CCh) on the MLCK pathway in isolated bovine iris sphincter and furthermore to investigate the existence of the FP receptor in this tissue.	Carbachol	90-99	myosin light chain kinase, smooth muscle	Bos taurus	113-117
14729360-3	2004	The aim of this study was to determine the agonist activity of PGF2alpha, latanoprost and carbachol (CCh) on the MLCK pathway in isolated bovine iris sphincter and furthermore to investigate the existence of the FP receptor in this tissue.	Carbachol	101-104	myosin light chain kinase, smooth muscle	Bos taurus	113-117
14729360-6	2004	The data obtained on the MLCK pathway showed that the three agonists stimulated the biochemical and pharmacological responses in a concentration and time-dependent manner and that the order of potency and efficacy is PGF2alpha&gt;latanoprost&gt;CCh.	Carbachol	245-248	myosin light chain kinase, smooth muscle	Bos taurus	25-29
14713860-9	2004	The loss of Cav-1 generated caveolae led to significant urogenital changes in male mice (most marked by 12 months of age), namely 1) bladder weight-to-body weight ratios were increased, 2) the bladder smooth muscle layer was thickened, 3) the bladders had increased baseline, threshold and spontaneous pressures, 4) bladder strips showed a decreased contractile response to carbachol and KCl, and 5) these smooth muscle changes were accompanied by marked fluid accumulation in the prostate and seminal vesicles, with intracellular vacuolization in the kidneys.	Carbachol	374-383	caveolin 1, caveolae protein	Mus musculus	12-17
14764222-1	2004	OBJECTIVE: To investigate the effects of carbachol injection in intestine on plasma levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-10 (IL-10) and cortisol in rats during gut ischemia/reperfusion.	Carbachol	41-50	tumor necrosis factor	Rattus norvegicus	122-131
14764222-1	2004	OBJECTIVE: To investigate the effects of carbachol injection in intestine on plasma levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-10 (IL-10) and cortisol in rats during gut ischemia/reperfusion.	Carbachol	41-50	interleukin 10	Rattus norvegicus	134-148
14764222-1	2004	OBJECTIVE: To investigate the effects of carbachol injection in intestine on plasma levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-10 (IL-10) and cortisol in rats during gut ischemia/reperfusion.	Carbachol	41-50	interleukin 10	Rattus norvegicus	150-155
14764222-5	2004	RESULTS: The plasma levels of TNF-alpha significantly decreased in pretreated and treated groups than those in controls after carbachol injection (both P&lt;0.01).	Carbachol	126-135	tumor necrosis factor	Rattus norvegicus	30-39
14752030-8	2004	ISO-activated systolic function was inhibited 85% by concomitant muscarinic stimulation (carbachol) in NOS3(-/-)+AdV(NOS3) but not NOS3(-/-)+AdVbeta(gal) hearts.	Carbachol	89-98	nitric oxide synthase 3, endothelial cell	Mus musculus	117-121
14752030-8	2004	ISO-activated systolic function was inhibited 85% by concomitant muscarinic stimulation (carbachol) in NOS3(-/-)+AdV(NOS3) but not NOS3(-/-)+AdVbeta(gal) hearts.	Carbachol	89-98	nitric oxide synthase 3, endothelial cell	Mus musculus	117-121
14670369-2	2004	To assess the PLC activity underlying carbachol-induced [Ca(2+)](i) oscillations in single HEK293 cells, we co-imaged [Ca(2+)](i) with fluorescent fusion proteins of protein kinase C (PKC) isotypes and the PH domain of PLC-delta 1 (PLC-delta 1(PH)).	Carbachol	38-47	protein kinase C alpha	Homo sapiens	184-187
14625299-7	2004	Both PS1 M146V and PS1 L250S cells showed a significant increase in carbachol-induced [Ca2+]i as compared with nontransfected or wild type PS1 transfected cells.	Carbachol	68-77	presenilin 1	Homo sapiens	5-8
14625299-7	2004	Both PS1 M146V and PS1 L250S cells showed a significant increase in carbachol-induced [Ca2+]i as compared with nontransfected or wild type PS1 transfected cells.	Carbachol	68-77	presenilin 1	Homo sapiens	19-22
14625299-7	2004	Both PS1 M146V and PS1 L250S cells showed a significant increase in carbachol-induced [Ca2+]i as compared with nontransfected or wild type PS1 transfected cells.	Carbachol	68-77	presenilin 1	Homo sapiens	19-22
14625299-9	2004	The cells expressing either PS1 D257A or PS1 D385N had attenuated carbachol-stimulated PI hydrolysis and [Ca2+]i responses.	Carbachol	66-75	presenilin 1	Homo sapiens	28-31
14625299-9	2004	The cells expressing either PS1 D257A or PS1 D385N had attenuated carbachol-stimulated PI hydrolysis and [Ca2+]i responses.	Carbachol	66-75	presenilin 1	Homo sapiens	41-44
14670369-2	2004	To assess the PLC activity underlying carbachol-induced [Ca(2+)](i) oscillations in single HEK293 cells, we co-imaged [Ca(2+)](i) with fluorescent fusion proteins of protein kinase C (PKC) isotypes and the PH domain of PLC-delta 1 (PLC-delta 1(PH)).	Carbachol	38-47	phospholipase C delta 1	Homo sapiens	219-230
14670369-2	2004	To assess the PLC activity underlying carbachol-induced [Ca(2+)](i) oscillations in single HEK293 cells, we co-imaged [Ca(2+)](i) with fluorescent fusion proteins of protein kinase C (PKC) isotypes and the PH domain of PLC-delta 1 (PLC-delta 1(PH)).	Carbachol	38-47	phospholipase C delta 1	Homo sapiens	232-243
15315164-5	2004	The results showed that as compared with control group, M3 cholinergic receptor agonist (10(-3) mol/L, 10(-4) mol/L carbachol) could induce a concentration-dependent and time-dependent increase in the expression of MOB-1, MCP-1 mRNA in pancreatic acinar cells.	Carbachol	116-125	multigenic obesity QTL 1	Mus musculus	215-220
15315164-5	2004	The results showed that as compared with control group, M3 cholinergic receptor agonist (10(-3) mol/L, 10(-4) mol/L carbachol) could induce a concentration-dependent and time-dependent increase in the expression of MOB-1, MCP-1 mRNA in pancreatic acinar cells.	Carbachol	116-125	mast cell protease 1	Mus musculus	222-227
15315164-6	2004	After treatment with 10(-3) mol/L carbachol for 2 h, the expression of MOB-1, MCP-1 mRNA was strongest.	Carbachol	34-43	multigenic obesity QTL 1	Mus musculus	71-76
15315164-6	2004	After treatment with 10(-3) mol/L carbachol for 2 h, the expression of MOB-1, MCP-1 mRNA was strongest.	Carbachol	34-43	mast cell protease 1	Mus musculus	78-83
15315164-7	2004	The activity of NF-kappaB in pancreatic acinar cells was significantly increased (P&lt;0.01) after treated with M3 cholinergic receptor agonist (10(-3) mol/L carbachol) in vitro for 30 min.	Carbachol	158-167	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	16-25
15315164-8	2004	Either M3 cholinergic receptor antagonist (10(-5) mol/L atropine) or NF-kappaB inhibitor (10(-2) mol/L PDTC) could obviously inhibit the activation of NF-kappaB and the chemokine MOB-1, MCP-1 mRNA expression induced by carbachol (P&lt;0.05).	Carbachol	219-228	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
15315164-8	2004	Either M3 cholinergic receptor antagonist (10(-5) mol/L atropine) or NF-kappaB inhibitor (10(-2) mol/L PDTC) could obviously inhibit the activation of NF-kappaB and the chemokine MOB-1, MCP-1 mRNA expression induced by carbachol (P&lt;0.05).	Carbachol	219-228	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	151-160
15477126-4	2004	Our results indicate that the cholinergic agonist acetylcholine (ACh) and its analog carbachol (CCh) exhibited comparable CCRC profiles in contracting isolated tracheae from both WT and ITK-/- mice, with no alteration in their efficacies.	Carbachol	85-94	IL2 inducible T cell kinase	Mus musculus	186-189
15390173-4	2004	Carbachol (CCh, applied to the bath) induced a decrease in the field responses (40-50% at 50 microM; 60% at 100 microM) to CA1, presubicular (PreS), and medial entorhinal (MEC) stimulation.	Carbachol	0-9	carbonic anhydrase 1	Rattus norvegicus	123-126
15390173-4	2004	Carbachol (CCh, applied to the bath) induced a decrease in the field responses (40-50% at 50 microM; 60% at 100 microM) to CA1, presubicular (PreS), and medial entorhinal (MEC) stimulation.	Carbachol	11-14	carbonic anhydrase 1	Rattus norvegicus	123-126
15390173-8	2004	When CA1 afferents were repetitively activated with submaximal stimuli in the presence of CCh, population excitatory postsynaptic potentials (EPSPs) showed modest summation, but every response was smaller than a corresponding events in normal media.	Carbachol	90-93	carbonic anhydrase 1	Rattus norvegicus	5-8
15390173-11	2004	We conclude that CA1, PreS, and MEC afferents to the subiculum exhibit CCh sensitivity similar to that established for area CA3 afferents to CA1, and LEC afferents to subiculum exhibit CCh resistance.	Carbachol	71-74	carbonic anhydrase 1	Rattus norvegicus	17-20
14512413-3	2003	When ileal smooth muscle strips were cultured with IL-1beta (10 ng/ml), contractions elicited by high K+ and carbachol were inhibited in a time-dependent manner.	Carbachol	109-118	interleukin 1 beta	Rattus norvegicus	51-59
14597600-3	2003	In murine tracheal rings, IL-13 (100 ng ml-1, 24 h) significantly increased both the carbachol- and KCl-induced maximal force generation without affecting ASM sensitivity.	Carbachol	85-94	interleukin 13	Mus musculus	26-31
14597600-4	2003	In cultured human ASM cells, IL-13 (50 ng ml-1, 24 h) also augmented cytosolic calcium levels to bradykinin, histamine and carbachol by 60, 35 and 26%, respectively.	Carbachol	123-132	interleukin 13	Homo sapiens	29-34
14575865-2	2003	In this study, we show that PAK1 can be stimulated by carbachol, lysophosphatidic acid (LPA), epidermal growth factor (EGF), and phorbol 12-myristate 13-acetate (PMA) by multiple independent and overlapping pathways.	Carbachol	54-63	p21 (RAC1) activated kinase 1	Homo sapiens	28-32
14717603-9	2004	For the dominant, rapidly desensitizing isoform, the carbamoylcholine dissociation constant for the site controlling receptor activation, Kd, is 2 mM; the channel-opening equilibrium constant, Phi(-1), is 4; and the dominant desensitization rate constant, k34, is 20 s(-1).	Carbachol	53-69	protein phosphatase 1 regulatory inhibitor subunit 14B	Homo sapiens	193-199
14717603-9	2004	For the dominant, rapidly desensitizing isoform, the carbamoylcholine dissociation constant for the site controlling receptor activation, Kd, is 2 mM; the channel-opening equilibrium constant, Phi(-1), is 4; and the dominant desensitization rate constant, k34, is 20 s(-1).	Carbachol	53-69	keratin 34	Homo sapiens	256-259
14512413-4	2003	IL-1beta more strongly inhibited the carbachol-induced contractions than high K+ with decreasing myosin light chain phosphorylation.	Carbachol	37-46	interleukin 1 beta	Rattus norvegicus	0-8
14512413-5	2003	In the alpha-toxin-permeabilized ileal muscle, carbachol with GTP or guanosine 5"-3-O-(thio)triphosphate increased the Ca2+ sensitivity of contractile elements, and this G protein-coupled Ca2+ sensitization was significantly reduced in the IL-1beta-treated ileum.	Carbachol	47-56	interleukin 1 beta	Rattus norvegicus	240-248
14512413-7	2003	The phosphorylation level of CPI-17 by carbachol was low in accordance with the decrease in CPI-17 expression due to IL-1beta treatment.	Carbachol	39-48	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	29-35
12880387-3	2003	In the present study, fast-scanning confocal microscopy revealed that activation of mu-opioid receptors alone by 1 muM DAMGO ([L-Ala, NMe-Phe, Gly-ol]-enkephalin) did not stimulate the Ins P3-dependent elementary Ca2+-signalling events (Ca2+ puffs), whereas DAMGO did evoke Ca2+ puffs when applied during concomitant activation of M3 muscarinic receptors with 1 muM carbachol.	Carbachol	366-375	latexin	Homo sapiens	115-118
12827518-3	2003	Activation of S2-DM1 receptors using CCh resulted in an increase in intracellular calcium ([Ca(2+)](i)) that was biphasic.	Carbachol	37-40	muscarinic Acetylcholine Receptor, A-type	Drosophila melanogaster	17-20
12827518-5	2003	Spatiotemporal imaging of individual S2-DM1 cells showed that the CCh-induced [Ca(2+)](i) transient resulted from a homogeneous calcium increase throughout the cell, indicative of calcium release from internal stores.	Carbachol	66-69	muscarinic Acetylcholine Receptor, A-type	Drosophila melanogaster	40-43
14629627-4	2003	Exposure to CCh diminished the cells" ability to elevate cytosolic Ca2+ and secrete beta-hexosaminidase in response to acute stimulation with 100 microM CCh, but it enhanced their secretory responses to phenylephrine and ionomycin.	Carbachol	12-15	O-GlcNAcase	Homo sapiens	84-103
14534236-3	2003	We mapped the distribution of receptors on the membrane of rat hippocampal CA1 stratum radiatum interneurons and pyramidal cells in acute slices by recording nAChR-mediated currents elicited by local UV laser-based photolysis of caged carbachol in patch-clamped neurons.	Carbachol	235-244	carbonic anhydrase 1	Rattus norvegicus	75-78
14534236-3	2003	We mapped the distribution of receptors on the membrane of rat hippocampal CA1 stratum radiatum interneurons and pyramidal cells in acute slices by recording nAChR-mediated currents elicited by local UV laser-based photolysis of caged carbachol in patch-clamped neurons.	Carbachol	235-244	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	158-163
14517795-3	2003	We examined whether GH inhibits chloride secretion induced by carbachol (CCh, a calcium-dependent pathway), and the downstream effectors responsible.	Carbachol	62-71	growth hormone 1	Homo sapiens	20-22
14517795-3	2003	We examined whether GH inhibits chloride secretion induced by carbachol (CCh, a calcium-dependent pathway), and the downstream effectors responsible.	Carbachol	73-76	growth hormone 1	Homo sapiens	20-22
14517795-7	2003	RESULTS: GH inhibited CCh-induced chloride secretion at up to 10 nmol/L, but higher concentrations were less effective.	Carbachol	22-25	growth hormone 1	Homo sapiens	9-11
14517795-14	2003	CONCLUSIONS: GH inhibits CCh-induced chloride secretion via a JAK2-dependent mechanism involving transactivation of EGFr and consequent recruitment of ERK1/2.	Carbachol	25-28	growth hormone 1	Homo sapiens	13-15
14517795-14	2003	CONCLUSIONS: GH inhibits CCh-induced chloride secretion via a JAK2-dependent mechanism involving transactivation of EGFr and consequent recruitment of ERK1/2.	Carbachol	25-28	Janus kinase 2	Homo sapiens	62-66
14517795-14	2003	CONCLUSIONS: GH inhibits CCh-induced chloride secretion via a JAK2-dependent mechanism involving transactivation of EGFr and consequent recruitment of ERK1/2.	Carbachol	25-28	epidermal growth factor receptor	Homo sapiens	116-120
14517795-14	2003	CONCLUSIONS: GH inhibits CCh-induced chloride secretion via a JAK2-dependent mechanism involving transactivation of EGFr and consequent recruitment of ERK1/2.	Carbachol	25-28	mitogen-activated protein kinase 3	Homo sapiens	151-157
14519434-9	2003	The carbachol (10 micromol/l)-induced increase in aaGTP binding was significantly higher in RA than in LV for Goalpha-1/3 (336 +/- 95% of LV, n = 4) and for Gialpha-3 (211 +/- 83%), lower for Gialpha-2 (42 +/- 5%), and was similar in both regions for Goalpha-2 (130 +/- 62%).	Carbachol	4-13	tripartite motif containing 47	Homo sapiens	110-117
14519434-9	2003	The carbachol (10 micromol/l)-induced increase in aaGTP binding was significantly higher in RA than in LV for Goalpha-1/3 (336 +/- 95% of LV, n = 4) and for Gialpha-3 (211 +/- 83%), lower for Gialpha-2 (42 +/- 5%), and was similar in both regions for Goalpha-2 (130 +/- 62%).	Carbachol	4-13	G protein subunit alpha i3	Homo sapiens	157-166
14519434-9	2003	The carbachol (10 micromol/l)-induced increase in aaGTP binding was significantly higher in RA than in LV for Goalpha-1/3 (336 +/- 95% of LV, n = 4) and for Gialpha-3 (211 +/- 83%), lower for Gialpha-2 (42 +/- 5%), and was similar in both regions for Goalpha-2 (130 +/- 62%).	Carbachol	4-13	tripartite motif containing 47	Homo sapiens	251-258
12893840-4	2003	In cultured hippocampal slices, CX614, a second ampakine CX546, and the cholinergic agonist carbachol each increased BDNF mRNA levels with acute (3-h) treatment.	Carbachol	92-101	brain-derived neurotrophic factor	Rattus norvegicus	117-121
14629627-4	2003	Exposure to CCh diminished the cells" ability to elevate cytosolic Ca2+ and secrete beta-hexosaminidase in response to acute stimulation with 100 microM CCh, but it enhanced their secretory responses to phenylephrine and ionomycin.	Carbachol	153-156	O-GlcNAcase	Homo sapiens	84-103
14500755-5	2003	The inhibition of Kir2.1 by carbachol was reversible and atropine-sensitive.	Carbachol	28-37	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	18-24
14500755-6	2003	Cotransfection with a dominant-negative mutant of the small GTPase Rho abolished the inhibition of Kir2.1 with current amplitudes remaining at control levels in the presence of carbachol.	Carbachol	177-186	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	99-105
14500755-8	2003	To further confirm the involvement of Rho in the signal transduction pathway, cotransfection with C3 transferase (EFC3), a selective inhibitor of Rho, abolished the reduction in Kir2.1 currents noted upon application of carbachol under control conditions.	Carbachol	220-229	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	178-184
13679249-8	2003	Repeated injections of carbachol (30 pmol) into the LSD produced Fos immunoreactivity in the ipsilateral side of the LSV.	Carbachol	23-32	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-68
12807915-3	2003	Purified G beta gamma, alone or with phosphatidylinositol 4,5-bisphosphate (PIP2), inhibited carbachol-evoked membrane recruitment of tubulin and G alpha q transactivation by tubulin.	Carbachol	93-102	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	9-15
12807915-3	2003	Purified G beta gamma, alone or with phosphatidylinositol 4,5-bisphosphate (PIP2), inhibited carbachol-evoked membrane recruitment of tubulin and G alpha q transactivation by tubulin.	Carbachol	93-102	G protein subunit alpha q	Homo sapiens	146-155
12807915-4	2003	Polymerization of microtubules elicited by G beta gamma overrode tubulin translocation to the membrane in response to carbachol stimulation.	Carbachol	118-127	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	43-49
12807915-8	2003	Both confocal microscopy and coimmunoprecipitation studies revealed the spatiotemporal pattern of G beta gamma/tubulin interaction during carbachol stimulation of neuroblastoma SK-N-SH cells.	Carbachol	138-147	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	98-104
12807915-11	2003	Fifteen min post-carbachol addition, tubulin and G beta colocalized in vesicle-like structures in the cytosol.	Carbachol	17-26	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	49-55
12747804-1	2003	In 1321N1 astrocytoma cells, carbachol stimulation of M3 muscarinic cholinergic receptors, coupled to phospholipase C, evoked a persistent 10-20-fold activation of p70 S6 kinase (S6K1).	Carbachol	29-38	ribosomal protein S6 kinase B1	Homo sapiens	179-183
12893847-11	2003	Although forskolin interacted with carbachol, allowing acid secretion in HDC-/- mice, similar results were not achieved with gastrin.	Carbachol	35-44	histidine decarboxylase	Mus musculus	73-76
12893847-12	2003	Such results suggest that 1) histamine is essential for carbachol- and gastrin-stimulated gastric acid secretion in mice; and 2) histamine-induced cAMP production contributes to the in vivo response to carbachol or gastrin.	Carbachol	202-211	gastrin	Mus musculus	71-78
12890474-5	2003	Activation of cholinergic receptors in cultured chick atrial myocytes by carbachol produced an outward potassium current (I(K(ACh))), which was attenuated by 24-48-h pre-treatment with neuregulin-1.	Carbachol	73-82	neuregulin 1	Gallus gallus	185-197
12922936-6	2003	Induction of inducible nitric oxide synthase (iNOS) impaired the stimulated NO synthesis from eNOS (100 nM carbachol-stimulated NO: control 5.7+/-0.6, iNOS 0.3+/-0.3 nM).	Carbachol	107-116	nitric oxide synthase 2	Rattus norvegicus	13-44
12922936-6	2003	Induction of inducible nitric oxide synthase (iNOS) impaired the stimulated NO synthesis from eNOS (100 nM carbachol-stimulated NO: control 5.7+/-0.6, iNOS 0.3+/-0.3 nM).	Carbachol	107-116	nitric oxide synthase 2	Rattus norvegicus	46-50
12922936-6	2003	Induction of inducible nitric oxide synthase (iNOS) impaired the stimulated NO synthesis from eNOS (100 nM carbachol-stimulated NO: control 5.7+/-0.6, iNOS 0.3+/-0.3 nM).	Carbachol	107-116	nitric oxide synthase 2	Rattus norvegicus	151-155
12922936-9	2003	Impairment of eNOS by iNOS was also prevented by L-arginine 100 micro M administered simultaneously with carbachol, but not by L-arginine administered during incubation with lipopolysaccharide.	Carbachol	105-114	nitric oxide synthase 2	Rattus norvegicus	22-26
14616247-9	2003	Addition of carbachol (10-4 m) increased average DAF-2 fluorescence by 22.8% and endothelial calcium concentration by 28.9%, whereas the arteriolar diameter remained essentially unchanged.	Carbachol	12-21	CD55 molecule (Cromer blood group)	Homo sapiens	49-52
12747804-2	2003	This response was abolished by chelation of cytosolic Ca2+ and reproduced by the Ca2+ ionophore ionomycin, but was not prevented by down-regulation or inhibition of protein kinase C. Carbachol-stimulated activation and phosphorylation of S6K1 at Thr389 were prevented by rapamycin, an inhibitor of mTOR (mammalian target of rapamycin), or by wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor.	Carbachol	183-192	ribosomal protein S6 kinase B1	Homo sapiens	238-242
12730147-4	2003	We found that in tracheal rings treated with 50 ng/ml TNF-alpha, carbachol-induced isometric force was significantly increased by 30% compared with those treated with diluent alone (P &lt; 0.05).	Carbachol	65-74	tumor necrosis factor	Mus musculus	54-63
12747804-2	2003	This response was abolished by chelation of cytosolic Ca2+ and reproduced by the Ca2+ ionophore ionomycin, but was not prevented by down-regulation or inhibition of protein kinase C. Carbachol-stimulated activation and phosphorylation of S6K1 at Thr389 were prevented by rapamycin, an inhibitor of mTOR (mammalian target of rapamycin), or by wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor.	Carbachol	183-192	mechanistic target of rapamycin kinase	Homo sapiens	298-302
12747804-2	2003	This response was abolished by chelation of cytosolic Ca2+ and reproduced by the Ca2+ ionophore ionomycin, but was not prevented by down-regulation or inhibition of protein kinase C. Carbachol-stimulated activation and phosphorylation of S6K1 at Thr389 were prevented by rapamycin, an inhibitor of mTOR (mammalian target of rapamycin), or by wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor.	Carbachol	183-192	mechanistic target of rapamycin kinase	Homo sapiens	304-333
12747804-2	2003	This response was abolished by chelation of cytosolic Ca2+ and reproduced by the Ca2+ ionophore ionomycin, but was not prevented by down-regulation or inhibition of protein kinase C. Carbachol-stimulated activation and phosphorylation of S6K1 at Thr389 were prevented by rapamycin, an inhibitor of mTOR (mammalian target of rapamycin), or by wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor.	Carbachol	183-192	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	356-381
12747804-3	2003	Carbachol also stimulated the phosphorylation of eukaryotic initiation factor 4E-binding protein-1 (4E-BP1), a second mTOR-dependent event, with similar potency to its effect on S6K1.	Carbachol	0-9	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	100-106
12747804-3	2003	Carbachol also stimulated the phosphorylation of eukaryotic initiation factor 4E-binding protein-1 (4E-BP1), a second mTOR-dependent event, with similar potency to its effect on S6K1.	Carbachol	0-9	mechanistic target of rapamycin kinase	Homo sapiens	118-122
12747804-3	2003	Carbachol also stimulated the phosphorylation of eukaryotic initiation factor 4E-binding protein-1 (4E-BP1), a second mTOR-dependent event, with similar potency to its effect on S6K1.	Carbachol	0-9	ribosomal protein S6 kinase B1	Homo sapiens	178-182
12747804-6	2003	By contrast, an inhibitor of epidermal growth factor receptor kinase, AG1478, which prevents carbachol-stimulated ErbB3 transactivation, PI3K recruitment and protein kinase B activation in 1321N1 cells, reduced activation of S6K1 by no more than 30%.	Carbachol	93-102	erb-b2 receptor tyrosine kinase 3	Homo sapiens	114-119
12747804-6	2003	By contrast, an inhibitor of epidermal growth factor receptor kinase, AG1478, which prevents carbachol-stimulated ErbB3 transactivation, PI3K recruitment and protein kinase B activation in 1321N1 cells, reduced activation of S6K1 by no more than 30%.	Carbachol	93-102	ribosomal protein S6 kinase B1	Homo sapiens	225-229
12911748-8	2003	DSI was observed in CA1 pyramidal neurons under control conditions, and its incidence was greatly increased by the cholinergic agonist carbachol.	Carbachol	135-144	carbonic anhydrase 1	Rattus norvegicus	20-23
12799421-3	2003	In both cell types, GPI-ACE, but not WT-ACE, was sequestered in caveolin or flotillin-enriched lipid rafts and was released from the cell surface by treatment with phosphatidylinositol-specific phospholipase C. When cells were treated with activators of the protein kinase C signalling cascade (phorbol myristate acetate or carbachol) the shedding of GPI-ACE was stimulated to a similar extent to that of WT-ACE.	Carbachol	324-333	angiotensin I converting enzyme	Homo sapiens	24-27
12730147-6	2003	The enhancing effect of TNF-alpha on carbachol-induced isometric force generation was completely abrogated in the tracheal rings obtained from TNF-alpha receptor (TNFR)1-deficient mice and in control rings treated with a TNF-alpha mutant that solely activates TNFR2.	Carbachol	37-46	tumor necrosis factor	Mus musculus	24-33
12730147-6	2003	The enhancing effect of TNF-alpha on carbachol-induced isometric force generation was completely abrogated in the tracheal rings obtained from TNF-alpha receptor (TNFR)1-deficient mice and in control rings treated with a TNF-alpha mutant that solely activates TNFR2.	Carbachol	37-46	tumor necrosis factor	Mus musculus	143-152
12730147-6	2003	The enhancing effect of TNF-alpha on carbachol-induced isometric force generation was completely abrogated in the tracheal rings obtained from TNF-alpha receptor (TNFR)1-deficient mice and in control rings treated with a TNF-alpha mutant that solely activates TNFR2.	Carbachol	37-46	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	163-169
12730147-6	2003	The enhancing effect of TNF-alpha on carbachol-induced isometric force generation was completely abrogated in the tracheal rings obtained from TNF-alpha receptor (TNFR)1-deficient mice and in control rings treated with a TNF-alpha mutant that solely activates TNFR2.	Carbachol	37-46	tumor necrosis factor	Mus musculus	143-152
12730147-6	2003	The enhancing effect of TNF-alpha on carbachol-induced isometric force generation was completely abrogated in the tracheal rings obtained from TNF-alpha receptor (TNFR)1-deficient mice and in control rings treated with a TNF-alpha mutant that solely activates TNFR2.	Carbachol	37-46	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	260-265
12842132-5	2003	These results suggest that carbachol-activation of M(1) mAChRs increases m1 mAChR, nNOS and iNOS mRNA levels associated with increased production of nitric oxide (NO).	Carbachol	27-36	nitric oxide synthase 1	Homo sapiens	83-87
12842132-5	2003	These results suggest that carbachol-activation of M(1) mAChRs increases m1 mAChR, nNOS and iNOS mRNA levels associated with increased production of nitric oxide (NO).	Carbachol	27-36	nitric oxide synthase 2	Homo sapiens	92-96
12606302-12	2003	Finally, in parallel with the reduction in SK4 message observed in animals deprived of dietary K+, carbachol-induced 86Rb+ secretion was abolished in dietary K+-depleted animals.	Carbachol	99-108	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	43-46
12732636-13	2003	Cav1Delta51-169 also suppressed thapsigarginand carbachol-stimulated Ca2+ influx and increased the detergent solubility of TRPC1, although plasma membrane lipid raft domains were not disrupted.	Carbachol	48-57	caveolin 1	Canis lupus familiaris	0-15
12665513-0	2003	TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.	Carbachol	73-82	mitogen-activated protein kinase 14	Homo sapiens	86-122
12665513-2	2003	We found that TAO2 activity was increased by carbachol and that carbachol and the heterotrimeric G protein Galphao could activate p38 in 293 cells.	Carbachol	45-54	TAO kinase 2	Homo sapiens	14-18
12665513-2	2003	We found that TAO2 activity was increased by carbachol and that carbachol and the heterotrimeric G protein Galphao could activate p38 in 293 cells.	Carbachol	64-73	TAO kinase 2	Homo sapiens	14-18
12665513-2	2003	We found that TAO2 activity was increased by carbachol and that carbachol and the heterotrimeric G protein Galphao could activate p38 in 293 cells.	Carbachol	64-73	mitogen-activated protein kinase 14	Homo sapiens	130-133
12665513-3	2003	Using dominant interfering kinase mutants, we found that MEKs 3 and 6 and TAOs were required for p38 activation by carbachol or the constitutively active mutant GalphaoQ205L.	Carbachol	115-124	mitogen-activated protein kinase 14	Homo sapiens	97-100
12665513-7	2003	Taken together, these studies suggest that TAO protein kinases relay signals from carbachol through heterotrimeric G proteins to the p38 MAP kinase, which then activates TCFs in the nucleus.	Carbachol	82-91	mitogen-activated protein kinase 14	Homo sapiens	133-147
12672827-9	2003	Depletion of intracellular Ca2+ stores by lowering extracellular Ca2+ concentration and treatment with the Ca2+-ATPase inhibitor thapsigargin or the muscarinic receptor agonist carbachol further augmented hTRPM3-mediated Ca2+ entry.	Carbachol	177-186	transient receptor potential cation channel subfamily M member 3	Homo sapiens	205-211
12922941-4	2003	The Rho-kinase inhibitor Y27632 produced concentration-dependent decreases in tone raised by either the muscarinic receptor agonist carbachol (CCh), or the sarco-endoplasmic reticulum calcium ATPase inhibitor thapsigargin (Tg) (EC(50) values against CCh and Tg of 8.4+/-3.3 (n=6) and 6.1+/-2.1 (n=7) micro M, respectively).	Carbachol	132-141	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	4-14
12922941-4	2003	The Rho-kinase inhibitor Y27632 produced concentration-dependent decreases in tone raised by either the muscarinic receptor agonist carbachol (CCh), or the sarco-endoplasmic reticulum calcium ATPase inhibitor thapsigargin (Tg) (EC(50) values against CCh and Tg of 8.4+/-3.3 (n=6) and 6.1+/-2.1 (n=7) micro M, respectively).	Carbachol	143-146	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	4-14
12922941-4	2003	The Rho-kinase inhibitor Y27632 produced concentration-dependent decreases in tone raised by either the muscarinic receptor agonist carbachol (CCh), or the sarco-endoplasmic reticulum calcium ATPase inhibitor thapsigargin (Tg) (EC(50) values against CCh and Tg of 8.4+/-3.3 (n=6) and 6.1+/-2.1 (n=7) micro M, respectively).	Carbachol	250-253	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	4-14
12922941-11	2003	Western blot analysis of fractionated tissue samples probed for RhoA immunoreactivity, indicated that both CCh and Tg were able to induce translocation of RhoA from the cytosol to the membrane.	Carbachol	107-110	ras homolog family member A	Mus musculus	64-68
12922941-11	2003	Western blot analysis of fractionated tissue samples probed for RhoA immunoreactivity, indicated that both CCh and Tg were able to induce translocation of RhoA from the cytosol to the membrane.	Carbachol	107-110	ras homolog family member A	Mus musculus	155-159
12850283-2	2003	In PRL-treated islets, stimulation by glucose (8 mM), carbamylcholine chloride (CCh) and phorbol dibutyrate increased cAMP levels 40, 89, and 151%, respectively, above similarly stimulated control islets without PRL.	Carbachol	54-78	prolactin	Rattus norvegicus	3-6
12850283-2	2003	In PRL-treated islets, stimulation by glucose (8 mM), carbamylcholine chloride (CCh) and phorbol dibutyrate increased cAMP levels 40, 89, and 151%, respectively, above similarly stimulated control islets without PRL.	Carbachol	54-78	prolactin	Rattus norvegicus	212-215
12850283-2	2003	In PRL-treated islets, stimulation by glucose (8 mM), carbamylcholine chloride (CCh) and phorbol dibutyrate increased cAMP levels 40, 89, and 151%, respectively, above similarly stimulated control islets without PRL.	Carbachol	80-83	prolactin	Rattus norvegicus	3-6
12850283-2	2003	In PRL-treated islets, stimulation by glucose (8 mM), carbamylcholine chloride (CCh) and phorbol dibutyrate increased cAMP levels 40, 89, and 151%, respectively, above similarly stimulated control islets without PRL.	Carbachol	80-83	prolactin	Rattus norvegicus	212-215
12781924-2	2003	We also observed that, though several signal transduction pathways are relevant for carbachol-induced cell proliferation, activation of PKC zeta and p70S6 kinase is selectively inhibited by low concentrations of ethanol.	Carbachol	84-93	protein kinase C zeta	Homo sapiens	136-144
12781924-7	2003	Carbachol also induced phosphorylation of (Thr410)PKC zeta, (Ser473)Akt, and (Thr389)p70S6 kinase, and ethanol (50 mM) inhibited phosphorylation of PKC zeta and p70S6 kinase, but not of Akt.	Carbachol	0-9	protein kinase C zeta	Homo sapiens	50-58
12781924-7	2003	Carbachol also induced phosphorylation of (Thr410)PKC zeta, (Ser473)Akt, and (Thr389)p70S6 kinase, and ethanol (50 mM) inhibited phosphorylation of PKC zeta and p70S6 kinase, but not of Akt.	Carbachol	0-9	protein kinase C zeta	Homo sapiens	148-156
12781924-7	2003	Carbachol also induced phosphorylation of (Thr410)PKC zeta, (Ser473)Akt, and (Thr389)p70S6 kinase, and ethanol (50 mM) inhibited phosphorylation of PKC zeta and p70S6 kinase, but not of Akt.	Carbachol	0-9	AKT serine/threonine kinase 1	Homo sapiens	68-71
12788814-5	2003	(3) Go 6976, an inhibitor of calcium-dependent PKC, concentration-dependently antagonized the inhibitory effect of TPA, and, therefore, revealed the action of PKC-alpha on carbachol-induced acid secretion in rabbit parietal cells.	Carbachol	172-181	protein kinase C alpha type	Oryctolagus cuniculus	159-168
12745080-1	2003	In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA.	Carbachol	177-186	ras homolog family member A	Rattus norvegicus	56-60
12745080-1	2003	In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA.	Carbachol	177-186	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	88-95
12745080-1	2003	In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA.	Carbachol	177-186	ras homolog family member A	Rattus norvegicus	135-139
12745080-1	2003	In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA.	Carbachol	177-186	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	145-152
12652642-0	2003	Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol.	Carbachol	133-142	Synembryn	Caenorhabditis elegans	12-21
12743035-3	2003	We demonstrate that in squamous cell carcinoma cells, stimulation with the GPCR agonists LPA or carbachol specifically results in metalloprotease cleavage and release of amphiregulin (AR).	Carbachol	96-105	C-X-C motif chemokine receptor 6	Homo sapiens	75-79
12743035-3	2003	We demonstrate that in squamous cell carcinoma cells, stimulation with the GPCR agonists LPA or carbachol specifically results in metalloprotease cleavage and release of amphiregulin (AR).	Carbachol	96-105	amphiregulin	Homo sapiens	170-182
12743035-3	2003	We demonstrate that in squamous cell carcinoma cells, stimulation with the GPCR agonists LPA or carbachol specifically results in metalloprotease cleavage and release of amphiregulin (AR).	Carbachol	96-105	amphiregulin	Homo sapiens	184-186
12729842-5	2003	Although carbachol but not gastrin induced in vivo gastric acid production in histamine H(2) receptor-null mice, gastric pH was elevated by both muscarinic M(3) and gastrin antagonists.	Carbachol	9-18	histamine receptor H2	Mus musculus	78-101
12772861-4	2003	Carbachol increased (P &lt; 0.10) alpha-amylase and trypsin release in tissue collected from all calves.	Carbachol	0-9	alpha amylase	Bos taurus	34-47
12748850-6	2003	Carbachol also dose-dependently stimulated extracellular signal-regulated protein kinase (ERK) activation.	Carbachol	0-9	mitogen-activated protein kinase 1	Homo sapiens	43-88
12748850-6	2003	Carbachol also dose-dependently stimulated extracellular signal-regulated protein kinase (ERK) activation.	Carbachol	0-9	mitogen-activated protein kinase 1	Homo sapiens	90-93
12748850-7	2003	This effect was inhibited by PD98059, an inhibitor of extracellular signal-regulated protein kinase kinase, which also blocked carbachol activation of cell proliferation, indicating that the p21Ras-ERK pathway is an important signaling cascade in the mitogenic effect.	Carbachol	127-136	mitogen-activated protein kinase 1	Homo sapiens	54-99
12748850-7	2003	This effect was inhibited by PD98059, an inhibitor of extracellular signal-regulated protein kinase kinase, which also blocked carbachol activation of cell proliferation, indicating that the p21Ras-ERK pathway is an important signaling cascade in the mitogenic effect.	Carbachol	127-136	HRas proto-oncogene, GTPase	Homo sapiens	191-197
12748850-7	2003	This effect was inhibited by PD98059, an inhibitor of extracellular signal-regulated protein kinase kinase, which also blocked carbachol activation of cell proliferation, indicating that the p21Ras-ERK pathway is an important signaling cascade in the mitogenic effect.	Carbachol	127-136	mitogen-activated protein kinase 1	Homo sapiens	198-201
12748850-9	2003	RESULTS: Carbachol induced tyrosine phosphorylation of EGFR, which was abolished by an EGFR tyrosine kinase inhibitor AG1478.	Carbachol	9-18	epidermal growth factor receptor	Homo sapiens	55-59
12748850-9	2003	RESULTS: Carbachol induced tyrosine phosphorylation of EGFR, which was abolished by an EGFR tyrosine kinase inhibitor AG1478.	Carbachol	9-18	epidermal growth factor receptor	Homo sapiens	87-91
12748850-10	2003	Transactivation by carbachol was also abrogated by a metalloproteinases (MMPs) inhibitor GM6001 or an EGFR-blocking antibody (LA-1), suggesting that binding of EGFR ligand(s) produced by MMPs may initiate transactivation in a manner dependent on EGFR tyrosine kinase.	Carbachol	19-28	epidermal growth factor receptor	Homo sapiens	102-106
12748850-10	2003	Transactivation by carbachol was also abrogated by a metalloproteinases (MMPs) inhibitor GM6001 or an EGFR-blocking antibody (LA-1), suggesting that binding of EGFR ligand(s) produced by MMPs may initiate transactivation in a manner dependent on EGFR tyrosine kinase.	Carbachol	19-28	epidermal growth factor receptor	Homo sapiens	160-164
12748850-10	2003	Transactivation by carbachol was also abrogated by a metalloproteinases (MMPs) inhibitor GM6001 or an EGFR-blocking antibody (LA-1), suggesting that binding of EGFR ligand(s) produced by MMPs may initiate transactivation in a manner dependent on EGFR tyrosine kinase.	Carbachol	19-28	epidermal growth factor receptor	Homo sapiens	160-164
12692900-4	2003	Stimulation of neural precursor cells dissociated from embryonic day 13 rat cortical neuroepithelium with the muscarinic receptor agonist carbachol (CCh) induced phosphorylations of c-src that were detected by antibodies raised against phospho-Tyr416 (Ptyr416), phospho-Tyr527 (Ptyr527), and phospho-Tyr215 (Ptyr215) of the kinase.	Carbachol	138-147	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	182-187
12692900-4	2003	Stimulation of neural precursor cells dissociated from embryonic day 13 rat cortical neuroepithelium with the muscarinic receptor agonist carbachol (CCh) induced phosphorylations of c-src that were detected by antibodies raised against phospho-Tyr416 (Ptyr416), phospho-Tyr527 (Ptyr527), and phospho-Tyr215 (Ptyr215) of the kinase.	Carbachol	149-152	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	182-187
12755612-9	2003	Because the nAChR desensitizes rapidly, to make the required measurements a cell-flow technique with a time resolution of 10 ms was used to equilibrate BCH(3) cells containing the fetal mouse muscle-type nAChR with carbamoylcholine.	Carbachol	215-231	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	204-209
12692900-6	2003	Both extracellular signal-regulated kinase (Erk1/2) and CREB were significantly activated after CCh treatment indicated by increases in phosphorylation of these two proteins.	Carbachol	96-99	mitogen activated protein kinase 3	Rattus norvegicus	44-50
12692900-6	2003	Both extracellular signal-regulated kinase (Erk1/2) and CREB were significantly activated after CCh treatment indicated by increases in phosphorylation of these two proteins.	Carbachol	96-99	cAMP responsive element binding protein 1	Rattus norvegicus	56-60
12692900-7	2003	The c-Src inhibitor PP1 abolished the CCh-induced activation of Erk1/2 and CREB in a dose-dependent manner.	Carbachol	38-41	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	4-9
12692900-7	2003	The c-Src inhibitor PP1 abolished the CCh-induced activation of Erk1/2 and CREB in a dose-dependent manner.	Carbachol	38-41	neuropeptide Y receptor Y4	Rattus norvegicus	20-23
12692900-7	2003	The c-Src inhibitor PP1 abolished the CCh-induced activation of Erk1/2 and CREB in a dose-dependent manner.	Carbachol	38-41	mitogen activated protein kinase 3	Rattus norvegicus	64-70
12692900-7	2003	The c-Src inhibitor PP1 abolished the CCh-induced activation of Erk1/2 and CREB in a dose-dependent manner.	Carbachol	38-41	cAMP responsive element binding protein 1	Rattus norvegicus	75-79
12692900-8	2003	Moreover, CCh stimulated expression of the neuronal specific marker MAP2, which was inhibited by PP1.	Carbachol	10-13	microtubule-associated protein 2	Rattus norvegicus	68-72
12692900-8	2003	Moreover, CCh stimulated expression of the neuronal specific marker MAP2, which was inhibited by PP1.	Carbachol	10-13	neuropeptide Y receptor Y4	Rattus norvegicus	97-100
12692900-9	2003	Cell proliferation assays and immunocytochemistry revealed that PP1 inhibited the CCh-induced DNA synthesis and MAP2(+) production.	Carbachol	82-85	neuropeptide Y receptor Y4	Rattus norvegicus	64-67
12652642-6	2003	Furthermore, synembryn was shown to translocate to the plasma membrane in response to carbachol and isoproterenol.	Carbachol	86-95	Synembryn	Caenorhabditis elegans	13-22
12594217-9	2003	An investigation of tyrosine phosphorylation levels of the plasma membrane Ca(2+)-ATPase (PMCA) demonstrated that CCh stimulates an increase in tyrosine phosphorylation levels, which has been reported to inhibit Ca(2+) pump activity, whereas in contrast, BK stimulates a reduction of PMCA tyrosine phosphorylation levels.	Carbachol	114-117	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	59-88
12594217-2	2003	After depletion of Ca(2+) stores by either TG, BK, or CCh, the addition of Ca(2+) gave a much larger rise in Ca(2+) levels in CCh-treated and TG-treated cells than in cells treated with BK.	Carbachol	126-129	kininogen 1	Homo sapiens	186-188
12676367-0	2003	Rewarding injections of the cholinergic agonist carbachol into the ventral tegmental area induce locomotion and c-Fos expression in the retrosplenial area and supramammillary nucleus.	Carbachol	48-57	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-117
12676367-2	2003	To determine what brain regions are activated by such rewarding injections we studied the expression of the transcription factor c-Fos in local and distant brain regions following ventral tegmental injections of carbachol in rats.	Carbachol	212-221	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	129-134
12676367-5	2003	Ventral tegmental injections of carbachol induced c-Fos expression throughout the brain.	Carbachol	32-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-55
12670478-2	2003	Two Rho-kinase inhibitors, Y-27632 and fasudil (HA-1077), conspicuously suppressed the contractile responses to carbachol (CCh) and KCl as well as electrical field stimulation (EFS, 40 V, 0.5 ms, and 20 s).	Carbachol	112-121	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	4-14
12670478-2	2003	Two Rho-kinase inhibitors, Y-27632 and fasudil (HA-1077), conspicuously suppressed the contractile responses to carbachol (CCh) and KCl as well as electrical field stimulation (EFS, 40 V, 0.5 ms, and 20 s).	Carbachol	123-126	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	4-14
12670478-5	2003	The Rho-kinase inhibitors relaxed the fundic strips preconstricted by submaximal concentration of CCh or KCl in a concentration dependent manner.	Carbachol	98-101	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	4-14
12529321-11	2003	Surprisingly, carbachol-stimulated degranulation was blocked by antibody-mediated inhibition of the Class III PI 3-kinase hVPS34 or by titration of its product with FYVE domains.	Carbachol	14-23	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	122-128
12620895-9	2003	Carbachol also increased tyrosine phosphorylation of Pyk2, p60Src, and the epidermal growth factor receptor (EGFR).	Carbachol	0-9	protein tyrosine kinase 2 beta	Rattus norvegicus	53-57
12620895-9	2003	Carbachol also increased tyrosine phosphorylation of Pyk2, p60Src, and the epidermal growth factor receptor (EGFR).	Carbachol	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	59-65
12620895-9	2003	Carbachol also increased tyrosine phosphorylation of Pyk2, p60Src, and the epidermal growth factor receptor (EGFR).	Carbachol	0-9	epidermal growth factor receptor	Rattus norvegicus	75-107
12620895-9	2003	Carbachol also increased tyrosine phosphorylation of Pyk2, p60Src, and the epidermal growth factor receptor (EGFR).	Carbachol	0-9	epidermal growth factor receptor	Rattus norvegicus	109-113
12620895-10	2003	The Src inhibitor PP1 and the EGFR inhibitor AG-1478 completely inhibited carbachol-stimulated MAPK activation.	Carbachol	74-83	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	4-7
12620895-10	2003	The Src inhibitor PP1 and the EGFR inhibitor AG-1478 completely inhibited carbachol-stimulated MAPK activation.	Carbachol	74-83	neuropeptide Y receptor Y4	Rattus norvegicus	18-21
12620895-10	2003	The Src inhibitor PP1 and the EGFR inhibitor AG-1478 completely inhibited carbachol-stimulated MAPK activation.	Carbachol	74-83	epidermal growth factor receptor	Rattus norvegicus	30-34
12620895-12	2003	We conclude that carbachol transactivates the EGFR to activate MAPK, leading to conjunctival goblet cell secretion.	Carbachol	17-26	epidermal growth factor receptor	Rattus norvegicus	46-50
12620895-13	2003	In addition, carbachol also activates Pyk2 and p60Src that could play a role in the transactivation of the EGFR.	Carbachol	13-22	protein tyrosine kinase 2 beta	Rattus norvegicus	38-42
12620895-13	2003	In addition, carbachol also activates Pyk2 and p60Src that could play a role in the transactivation of the EGFR.	Carbachol	13-22	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	47-53
12620895-13	2003	In addition, carbachol also activates Pyk2 and p60Src that could play a role in the transactivation of the EGFR.	Carbachol	13-22	epidermal growth factor receptor	Rattus norvegicus	107-111
12631560-6	2003	Both NSCC activated by CCh in murine stomach and mTRP5 were inhibited by intracellularly applied anti-G(q/11) antibody, PLC inhibitor U-73122, IICR inhibitor 2-aminoethoxydiphenylborate, and nonspecific cation channel blockers La(3+) and flufenamate.	Carbachol	23-26	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	120-123
12631560-10	2003	From the above results, we suggest that mTRP5 might be a candidate for the NSCC activated by ACh or CCh in murine stomach.	Carbachol	100-103	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	40-45
12721115-9	2003	Moreover, treatment of OA-sensitized mice with HOE-140 (100 microg kg(-1)) completely abolished the AHR to carbachol.	Carbachol	107-116	aryl-hydrocarbon receptor	Mus musculus	100-103
12594217-9	2003	An investigation of tyrosine phosphorylation levels of the plasma membrane Ca(2+)-ATPase (PMCA) demonstrated that CCh stimulates an increase in tyrosine phosphorylation levels, which has been reported to inhibit Ca(2+) pump activity, whereas in contrast, BK stimulates a reduction of PMCA tyrosine phosphorylation levels.	Carbachol	114-117	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	90-94
12594217-9	2003	An investigation of tyrosine phosphorylation levels of the plasma membrane Ca(2+)-ATPase (PMCA) demonstrated that CCh stimulates an increase in tyrosine phosphorylation levels, which has been reported to inhibit Ca(2+) pump activity, whereas in contrast, BK stimulates a reduction of PMCA tyrosine phosphorylation levels.	Carbachol	114-117	kininogen 1	Homo sapiens	255-257
12594217-9	2003	An investigation of tyrosine phosphorylation levels of the plasma membrane Ca(2+)-ATPase (PMCA) demonstrated that CCh stimulates an increase in tyrosine phosphorylation levels, which has been reported to inhibit Ca(2+) pump activity, whereas in contrast, BK stimulates a reduction of PMCA tyrosine phosphorylation levels.	Carbachol	114-117	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	284-288
12594217-10	2003	Thus, BK and CCh have a differential effect both on Ca(2+) pump activity and on tyrosine phosphorylation levels of the PMCA.	Carbachol	13-16	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	119-123
12609749-6	2003	Hence, low concentrations of IAPP brought about a modest increase of basal insulin secretion at 7 mM glucose and also of insulin release stimulated by carbachol.	Carbachol	151-160	islet amyloid polypeptide	Homo sapiens	29-33
12628460-4	2003	Both CCh and PBr increased the relative amounts of Dsg 1 and Dsg 3.	Carbachol	5-8	desmoglein 1	Homo sapiens	51-56
12628460-4	2003	Both CCh and PBr increased the relative amounts of Dsg 1 and Dsg 3.	Carbachol	5-8	desmoglein 3	Homo sapiens	61-66
12628460-7	2003	The Atr-dependent phosphorylation of Dsg 3 was inhibited in the presence of 0.5 mM CCh.	Carbachol	83-86	desmoglein 3	Homo sapiens	37-42
12646175-5	2003	The neurotransmitters, which were implicated in sleep/wake regulation, affected the activity of orexin neurons; noradrenaline and serotonin hyperpolarized, while carbachol depolarized orexin neurons in either the presence or absence of tetrodotoxin.	Carbachol	162-171	hypocretin	Mus musculus	96-102
12646175-5	2003	The neurotransmitters, which were implicated in sleep/wake regulation, affected the activity of orexin neurons; noradrenaline and serotonin hyperpolarized, while carbachol depolarized orexin neurons in either the presence or absence of tetrodotoxin.	Carbachol	162-171	hypocretin	Mus musculus	184-190
12460119-2	2003	Exposure to carbachol elicited transient translocation of PKC alpha-EGFP and beta II-EGFP in most of the cells, PKC delta-EGFP in a few cells and induced sustained translocation of PKC epsilon-EGFP.	Carbachol	12-21	protein kinase C alpha	Homo sapiens	58-67
12460119-2	2003	Exposure to carbachol elicited transient translocation of PKC alpha-EGFP and beta II-EGFP in most of the cells, PKC delta-EGFP in a few cells and induced sustained translocation of PKC epsilon-EGFP.	Carbachol	12-21	protein kinase C delta	Homo sapiens	112-121
12460119-8	2003	Experiments with individual C1 domains showed that treatment with carbachol or phorbol 12,13-dibutyrate elicited translocation of PKC alpha C1a, PKC epsilon C1a and PKC epsilon C1b, whereas PKC alpha C1b was largely insensitive to these agents.	Carbachol	66-75	protein kinase C alpha	Homo sapiens	130-139
12460119-8	2003	Experiments with individual C1 domains showed that treatment with carbachol or phorbol 12,13-dibutyrate elicited translocation of PKC alpha C1a, PKC epsilon C1a and PKC epsilon C1b, whereas PKC alpha C1b was largely insensitive to these agents.	Carbachol	66-75	endogenous retrovirus group K member 1	Homo sapiens	140-143
12460119-8	2003	Experiments with individual C1 domains showed that treatment with carbachol or phorbol 12,13-dibutyrate elicited translocation of PKC alpha C1a, PKC epsilon C1a and PKC epsilon C1b, whereas PKC alpha C1b was largely insensitive to these agents.	Carbachol	66-75	proline rich transmembrane protein 2	Homo sapiens	130-133
12460119-9	2003	In contrast with full-length PKC alpha, the regulatory domain of PKC alpha and pseudosubstrate-devoid PKC alpha responded to the carbachol-stimulated increase in diacylglycerol.	Carbachol	129-138	protein kinase C alpha	Homo sapiens	65-74
12460119-9	2003	In contrast with full-length PKC alpha, the regulatory domain of PKC alpha and pseudosubstrate-devoid PKC alpha responded to the carbachol-stimulated increase in diacylglycerol.	Carbachol	129-138	protein kinase C alpha	Homo sapiens	65-74
12612139-9	2003	In conclusion, a reduced expression of PKCalpha and PLCbeta(1) may be involved in the decreased insulin secretion by islets from LP rats after stimulation with CCh and PMA.	Carbachol	160-163	protein kinase C, alpha	Rattus norvegicus	39-47
12612139-9	2003	In conclusion, a reduced expression of PKCalpha and PLCbeta(1) may be involved in the decreased insulin secretion by islets from LP rats after stimulation with CCh and PMA.	Carbachol	160-163	phospholipase C beta 1	Rattus norvegicus	52-62
12494403-4	2003	An in vitro electrophysiological study investigated the effect of isolation rearing on postsynaptic 5-HT(1A) function on CA1 hippocampal neurones activated with the muscarinic agonist carbachol and found no change in the sensitivity of these postsynaptic receptors between the groups.	Carbachol	184-193	carbonic anhydrase 1	Rattus norvegicus	121-124
12388102-8	2003	When cells were pretreated with SB-203580 and PD-98059 to simultaneously inhibit p38 and ERK MAPKs, respectively, I(sc) responses to TG and CCh were significantly greater than those observed with either inhibitor alone.	Carbachol	140-143	mitogen-activated protein kinase 14	Homo sapiens	81-84
12797549-4	2003	Both IFNgamma and carbachol triggered IFNgamma secretion in SMG.	Carbachol	18-27	interferon gamma	Mus musculus	38-46
12797549-7	2003	Moreover, cyclooxygenase-2 (COX-2) activation and subsequent PGE2 liberation, in a nitric oxide independent manner, seem to be involved in M3 and M2 receptor activation by carbachol.	Carbachol	172-181	prostaglandin-endoperoxide synthase 2	Mus musculus	10-26
12797549-7	2003	Moreover, cyclooxygenase-2 (COX-2) activation and subsequent PGE2 liberation, in a nitric oxide independent manner, seem to be involved in M3 and M2 receptor activation by carbachol.	Carbachol	172-181	prostaglandin-endoperoxide synthase 2	Mus musculus	28-33
12831623-0	2003	[Effects of carbachol on plasma levels of tumor necrosis factor-alpha and interleukin-10 in rats during gut ischemia-reperfusion].	Carbachol	12-21	tumor necrosis factor	Rattus norvegicus	42-69
12831623-0	2003	[Effects of carbachol on plasma levels of tumor necrosis factor-alpha and interleukin-10 in rats during gut ischemia-reperfusion].	Carbachol	12-21	interleukin 10	Rattus norvegicus	74-88
12831623-1	2003	OBJECTIVE: To investigate the effects of carbachol on the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10) and cortisol in plasma of rats during gut ischemia-reperfusion.	Carbachol	41-50	tumor necrosis factor	Rattus norvegicus	68-95
12831623-1	2003	OBJECTIVE: To investigate the effects of carbachol on the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10) and cortisol in plasma of rats during gut ischemia-reperfusion.	Carbachol	41-50	tumor necrosis factor	Rattus norvegicus	97-106
12831623-1	2003	OBJECTIVE: To investigate the effects of carbachol on the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10) and cortisol in plasma of rats during gut ischemia-reperfusion.	Carbachol	41-50	interleukin 10	Rattus norvegicus	109-123
12831623-1	2003	OBJECTIVE: To investigate the effects of carbachol on the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10) and cortisol in plasma of rats during gut ischemia-reperfusion.	Carbachol	41-50	interleukin 10	Rattus norvegicus	125-130
12831623-6	2003	The levels of TNF-alpha significantly decreased in pretreated and treated groups than that in control after the intramuscular injection of carbachol (all P&lt;0.01).	Carbachol	139-148	tumor necrosis factor	Rattus norvegicus	14-23
12609749-7	2003	High concentrations of IAPP, however, inhibited insulin release stimulated by glucose (10 and 16.7 mM), IBMX, carbachol and L-arginine.	Carbachol	110-119	islet amyloid polypeptide	Homo sapiens	23-27
12609749-7	2003	High concentrations of IAPP, however, inhibited insulin release stimulated by glucose (10 and 16.7 mM), IBMX, carbachol and L-arginine.	Carbachol	110-119	insulin	Homo sapiens	48-55
12388102-3	2003	Western blot analysis of T(84) colonic epithelial cells revealed that the muscarinic agonist carbachol (CCh; 100 microM) stimulated phosphorylation and activation of p38 MAPK.	Carbachol	93-102	mitogen-activated protein kinase 14	Homo sapiens	166-169
12388102-3	2003	Western blot analysis of T(84) colonic epithelial cells revealed that the muscarinic agonist carbachol (CCh; 100 microM) stimulated phosphorylation and activation of p38 MAPK.	Carbachol	104-107	mitogen-activated protein kinase 14	Homo sapiens	166-169
12388102-4	2003	The p38 inhibitor SB-203580 (10 microM) potentiated and prolonged short-circuit current (I(sc)) responses to CCh across voltage-clamped T(84) cells to 157.4 +/- 6.9% of those in control cells (n = 21; P &lt; 0.001).	Carbachol	109-112	mitogen-activated protein kinase 14	Homo sapiens	4-7
12388102-5	2003	CCh-induced p38 phosphorylation was attenuated by the EGFR inhibitor tyrphostin AG-1478 (0.1 nM-10 microM) and by the Src family kinase inhibitor PP2 (20 nM-2 microM).	Carbachol	0-3	mitogen-activated protein kinase 14	Homo sapiens	12-15
12388102-5	2003	CCh-induced p38 phosphorylation was attenuated by the EGFR inhibitor tyrphostin AG-1478 (0.1 nM-10 microM) and by the Src family kinase inhibitor PP2 (20 nM-2 microM).	Carbachol	0-3	epidermal growth factor receptor	Homo sapiens	54-58
12388102-5	2003	CCh-induced p38 phosphorylation was attenuated by the EGFR inhibitor tyrphostin AG-1478 (0.1 nM-10 microM) and by the Src family kinase inhibitor PP2 (20 nM-2 microM).	Carbachol	0-3	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	146-149
12388102-6	2003	The effects of CCh on p38 phosphorylation were mimicked by thapsigargin (TG; 2 microM), which specifically elevates intracellular Ca(2+), and were abolished by the Ca(2+) chelator BAPTA-AM (20 microM), implying a role for intracellular Ca(2+) in mediating p38 activation.	Carbachol	15-18	mitogen-activated protein kinase 14	Homo sapiens	22-25
12388102-6	2003	The effects of CCh on p38 phosphorylation were mimicked by thapsigargin (TG; 2 microM), which specifically elevates intracellular Ca(2+), and were abolished by the Ca(2+) chelator BAPTA-AM (20 microM), implying a role for intracellular Ca(2+) in mediating p38 activation.	Carbachol	15-18	mitogen-activated protein kinase 14	Homo sapiens	256-259
12388397-3	2003	Stimulation with carbachol or ATP decreased initial uptake by 44 +/- 3 (n = 14) and 34 +/- 4% (n = 21), respectively, independently of PKC but dependent on phosphatidylinositol 3-kinase (PI3K).	Carbachol	17-26	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	156-185
12610653-6	2003	In contrast, carbachol increases the secretion of sAPPalpha to similar levels in wild-type cells and in cells transfected with antisense PKCalpha by acting on APP metabolism through an indirect pathway partially involving the activation of PKC.	Carbachol	13-22	protein kinase C alpha	Homo sapiens	137-145
12610653-6	2003	In contrast, carbachol increases the secretion of sAPPalpha to similar levels in wild-type cells and in cells transfected with antisense PKCalpha by acting on APP metabolism through an indirect pathway partially involving the activation of PKC.	Carbachol	13-22	protein kinase C alpha	Homo sapiens	137-140
12524182-4	2003	In young adulthood (50 days old), control offspring showed an increase in hippocampal cell membrane PKCgamma after incubation with the muscarinic cholinergic receptor agonist, carbachol, indicative of translocation from the cytosol.	Carbachol	176-185	protein kinase C, gamma	Mus musculus	100-108
12388118-5	2003	Inhibition of EGF receptor (EGFR) with AG1478, an inhibitor of the EGFR tyrosine kinase activity, significantly increased phenylephrine- but not carbachol-induced protein secretion.	Carbachol	145-154	epidermal growth factor receptor	Rattus norvegicus	28-32
12388118-7	2003	Phenylephrine stimulated tyrosine phosphorylation of the EGFR, whereas carbachol stimulated p60(Src), and possibly Pyk2, to activate MAPK.	Carbachol	71-80	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	96-99
12388102-10	2003	CCh-stimulated p38 activation constitutes a similar, but distinct and complementary, antisecretory signaling pathway to that of ERK MAPK.	Carbachol	0-3	mitogen-activated protein kinase 14	Homo sapiens	15-18
12388118-7	2003	Phenylephrine stimulated tyrosine phosphorylation of the EGFR, whereas carbachol stimulated p60(Src), and possibly Pyk2, to activate MAPK.	Carbachol	71-80	protein tyrosine kinase 2 beta	Rattus norvegicus	115-119
12388102-10	2003	CCh-stimulated p38 activation constitutes a similar, but distinct and complementary, antisecretory signaling pathway to that of ERK MAPK.	Carbachol	0-3	mitogen-activated protein kinase 1	Homo sapiens	128-131
12388102-10	2003	CCh-stimulated p38 activation constitutes a similar, but distinct and complementary, antisecretory signaling pathway to that of ERK MAPK.	Carbachol	0-3	mitogen-activated protein kinase 1	Homo sapiens	132-136
12522076-1	2003	1 In fura 2-loaded HEK-293 cells stably expressing human type 1 parathyroid hormone (PTH) receptors, PTH potentiated the Ca(2+) mobilization evoked by carbachol by &gt;4 fold without itself increasing the intracellular [Ca(2+)].	Carbachol	151-160	parathyroid hormone	Homo sapiens	64-83
12388338-2	2003	Allergen challenge significantly reduced the relaxant effect of salbutamol on carbachol-induced contractions, suggesting beta(2)-adrenoceptor (beta(2)-AR) pathway dysfunction.	Carbachol	78-87	adrenoceptor beta 2	Homo sapiens	121-141
12388338-2	2003	Allergen challenge significantly reduced the relaxant effect of salbutamol on carbachol-induced contractions, suggesting beta(2)-adrenoceptor (beta(2)-AR) pathway dysfunction.	Carbachol	78-87	adrenoceptor beta 2	Homo sapiens	143-153
12388338-4	2003	Incubation with the G(s)alpha protein-stimulating cholera toxin attenuated contractile responses to carbachol significantly less in challenged than in unchallenged rings.	Carbachol	100-109	GNAS complex locus	Homo sapiens	20-29
12522076-1	2003	1 In fura 2-loaded HEK-293 cells stably expressing human type 1 parathyroid hormone (PTH) receptors, PTH potentiated the Ca(2+) mobilization evoked by carbachol by &gt;4 fold without itself increasing the intracellular [Ca(2+)].	Carbachol	151-160	parathyroid hormone	Homo sapiens	85-88
12522076-1	2003	1 In fura 2-loaded HEK-293 cells stably expressing human type 1 parathyroid hormone (PTH) receptors, PTH potentiated the Ca(2+) mobilization evoked by carbachol by &gt;4 fold without itself increasing the intracellular [Ca(2+)].	Carbachol	151-160	parathyroid hormone	Homo sapiens	101-104
12498921-0	2003	The indirect negative inotropic effect of carbachol in beta1-adrenoceptor antagonist-treated human right atria.	Carbachol	42-51	adrenoceptor beta 1	Homo sapiens	55-73
12498921-4	2003	pD(2) values for carbachol, however, were higher in atria from non-beta(1)-adrenoceptor antagonist-treated vs. beta(1)-adrenoceptor antagonist-treated patients.We conclude that, in isolated human right atria, carbachol-induced indirect negative inotropic effect is not dependent from the agonist employed to increase (via cyclic AMP accumulation) contractile force.	Carbachol	17-26	adrenoceptor beta 1	Homo sapiens	67-87
12498921-4	2003	pD(2) values for carbachol, however, were higher in atria from non-beta(1)-adrenoceptor antagonist-treated vs. beta(1)-adrenoceptor antagonist-treated patients.We conclude that, in isolated human right atria, carbachol-induced indirect negative inotropic effect is not dependent from the agonist employed to increase (via cyclic AMP accumulation) contractile force.	Carbachol	17-26	adrenoceptor beta 1	Homo sapiens	111-131
12498921-5	2003	However, in atria from beta(1)-adrenoceptor antagonist-treated patients, carbachol-induced indirect negative inotropic effect is attenuated.	Carbachol	73-82	adrenoceptor beta 1	Homo sapiens	23-43
12768388-0	2003	Relaxation effects of adrenomedullin in carbachol-precontracted rabbit internal anal sphincter.	Carbachol	40-49	ADM	Oryctolagus cuniculus	22-36
12576703-3	2003	In measurements of the relationship between [Ca(2+)](i) and tension in intact tissue, Y-27632, a ROK inhibitor, significantly attenuated the carbachol-induced contraction without changing [Ca (2+)](i).	Carbachol	141-150	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	97-100
12598604-4	2003	Activation of muscarinic acetylcholine receptors (mAChRs) with carbachol produced an enhancement of GABA(A) receptor currents in acutely dissociated cells after a short treatment with insulin.	Carbachol	63-72	insulin	Homo sapiens	184-191
12598604-5	2003	Inhibiting phosphoinositide-3 kinase (PI3K), a downstream target of insulin signaling, eliminated this effect as well as the carbachol-induced enhancement of GABAergic miniature IPSC amplitudes in PFC slices.	Carbachol	125-134	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	11-36
12598604-5	2003	Inhibiting phosphoinositide-3 kinase (PI3K), a downstream target of insulin signaling, eliminated this effect as well as the carbachol-induced enhancement of GABAergic miniature IPSC amplitudes in PFC slices.	Carbachol	125-134	insulin	Homo sapiens	68-75
12576703-4	2003	Phosphorylation of MLC(20) was increased by carbachol and this increased phosphorylation was blocked by treatment of tissue with Y-27632.	Carbachol	44-53	myosin light chain 12B	Rattus norvegicus	19-26
12763063-3	2003	We found that carbachol diminished excitatory post-synaptic responses induced by CA1 stratum radiatum stimulation in wild type mice, but caused an unexpected increase in knockout animals.	Carbachol	14-23	carbonic anhydrase 1	Mus musculus	81-84
12927200-5	2003	Carbachol activated NF-kappaB in human 1321N1 astrocytoma cells, as evidenced by translocation of the p65 subunit of NF-kappaB to the nucleus, phosphorylation and degradation of IkappaBalpha in the cytosol, and increase NF-kappaB binding to DNA.	Carbachol	0-9	nuclear factor kappa B subunit 1	Homo sapiens	20-29
12927200-5	2003	Carbachol activated NF-kappaB in human 1321N1 astrocytoma cells, as evidenced by translocation of the p65 subunit of NF-kappaB to the nucleus, phosphorylation and degradation of IkappaBalpha in the cytosol, and increase NF-kappaB binding to DNA.	Carbachol	0-9	RELA proto-oncogene, NF-kB subunit	Homo sapiens	102-105
12927200-5	2003	Carbachol activated NF-kappaB in human 1321N1 astrocytoma cells, as evidenced by translocation of the p65 subunit of NF-kappaB to the nucleus, phosphorylation and degradation of IkappaBalpha in the cytosol, and increase NF-kappaB binding to DNA.	Carbachol	0-9	nuclear factor kappa B subunit 1	Homo sapiens	117-126
12927200-5	2003	Carbachol activated NF-kappaB in human 1321N1 astrocytoma cells, as evidenced by translocation of the p65 subunit of NF-kappaB to the nucleus, phosphorylation and degradation of IkappaBalpha in the cytosol, and increase NF-kappaB binding to DNA.	Carbachol	0-9	NFKB inhibitor alpha	Homo sapiens	178-190
12927200-5	2003	Carbachol activated NF-kappaB in human 1321N1 astrocytoma cells, as evidenced by translocation of the p65 subunit of NF-kappaB to the nucleus, phosphorylation and degradation of IkappaBalpha in the cytosol, and increase NF-kappaB binding to DNA.	Carbachol	0-9	nuclear factor kappa B subunit 1	Homo sapiens	117-126
12927200-6	2003	Carbachol also induced translocation of p65 to the nucleus in primary rat astrocytes.	Carbachol	0-9	synaptotagmin 1	Rattus norvegicus	40-43
12927200-7	2003	Carbachol-induced NF-kappaB activation was mediated by the M3 subtype of muscarinic receptors and appeared to involve Ca(2+) mobilization and activation of PKC epsilon and PKC zeta, but not PI3-kinase and mitogen-activated protein kinase.	Carbachol	0-9	nuclear factor kappa B subunit 1	Homo sapiens	18-27
12927200-8	2003	The NF-kappaB peptide inhibitor SN50, but not the inactive peptide SN50M, strongly inhibited carbachol-induced astrocytoma cells proliferation and p65 translocation to the nucleus.	Carbachol	93-102	nuclear factor kappa B subunit 1	Homo sapiens	4-13
12927200-11	2003	Together, these results suggest that activation of NF-kappaB by muscarinic receptors in astroglial cells is important for carbachol-induced DNA synthesis and that ethanol-mediated inhibition of cell proliferation may be due in part to inhibition of NF-kappaB activation.	Carbachol	122-131	nuclear factor kappa B subunit 1	Homo sapiens	51-60
12518226-4	2003	In the present study, it was found that carbachol not only activated MEK/ERK-1/2 signaling pathways, but also increased the expression levels of Bcl-2 and phospho-Bad proteins in human neuroblastoma SH-SY5Y cells.	Carbachol	40-49	mitogen-activated protein kinase kinase 7	Homo sapiens	69-72
12518226-4	2003	In the present study, it was found that carbachol not only activated MEK/ERK-1/2 signaling pathways, but also increased the expression levels of Bcl-2 and phospho-Bad proteins in human neuroblastoma SH-SY5Y cells.	Carbachol	40-49	mitogen-activated protein kinase 3	Homo sapiens	73-80
12518226-4	2003	In the present study, it was found that carbachol not only activated MEK/ERK-1/2 signaling pathways, but also increased the expression levels of Bcl-2 and phospho-Bad proteins in human neuroblastoma SH-SY5Y cells.	Carbachol	40-49	BCL2 apoptosis regulator	Homo sapiens	145-150
12518226-6	2003	Furthermore, carbachol also stimulated Bcl-2 promoter-driven luciferase gene expression in transfected SH-SY5Y cells.	Carbachol	13-22	BCL2 apoptosis regulator	Homo sapiens	39-44
12368283-11	2002	Finally, in situ phosphorylation assays demonstrated that PMCA was phosphorylated by treatment with forskolin but only in the presence of carbamylcholine (carbachol).	Carbachol	138-153	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	58-62
12368283-11	2002	Finally, in situ phosphorylation assays demonstrated that PMCA was phosphorylated by treatment with forskolin but only in the presence of carbamylcholine (carbachol).	Carbachol	155-164	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	58-62
12368284-11	2002	Transient expression of the hTRPC3 protein enhanced Ca(2+) influx responsive to carbachol but did not increase EGF-activated Ca(2+) influx.	Carbachol	80-89	transient receptor potential cation channel subfamily C member 3	Homo sapiens	28-34
12374786-6	2002	The loss of Kir3.1 did not affect the level of atrial Kir3.4 protein but was correlated with a loss of carbachol-induced current in atrial myocytes.	Carbachol	103-112	potassium inwardly-rectifying channel, subfamily J, member 3	Mus musculus	12-18
12388311-9	2002	MAP 4 protein decorated the microtubules extensively, and receptor recovery upon carbachol withdrawal was reduced to 54% of control.	Carbachol	81-90	microtubule associated protein 4	Homo sapiens	0-5
12490593-2	2003	Magnitudes of acute, nAChR-mediated, specific 86Rb+ efflux responses to 1 mM carbamylcholine were reduced after pretreatment with specific nAChR ligands in effects that depended on pretreatment drug dose, duration of drug pretreatment, and duration of drug-free recovery.	Carbachol	77-92	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	21-26
12490593-2	2003	Magnitudes of acute, nAChR-mediated, specific 86Rb+ efflux responses to 1 mM carbamylcholine were reduced after pretreatment with specific nAChR ligands in effects that depended on pretreatment drug dose, duration of drug pretreatment, and duration of drug-free recovery.	Carbachol	77-92	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	139-144
12185080-7	2002	However, eNOS was tightly coupled with caveolin-1, and was dissociated from heat shock protein 90 or calmodulin in the hypoxic pulmonary artery in either the presence or absence of carbachol.	Carbachol	181-190	nitric oxide synthase 3	Rattus norvegicus	9-13
12429569-12	2002	Culture with TNFalpha produced a time- and concentration-dependent increase in the maximal contraction to 5-HT, evidently mediated by 5-HT(2A) receptors, whereas, the potency for carbachol was reduced.	Carbachol	179-188	tumor necrosis factor	Mus musculus	13-21
12492954-7	2002	The CCh-induced outward current was inhibited by iberiotoxin, a selective inhibitor of large-conductance Ca2+-activated K+ channels (BKCa).	Carbachol	4-7	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	133-137
12492954-8	2002	CONCLUSION: CCh induces BKCa, which is inhibited by M2- and Gi-mediated signal transduction pathway.	Carbachol	12-15	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	24-28
12372816-7	2002	The PKCepsilon-selective agonist carbachol (100 microM) induced prolonged stimulation of endocytosis devoid of an inhibitory phase.	Carbachol	33-42	protein kinase C epsilon	Homo sapiens	4-14
12202486-9	2002	A metalloproteinase inhibitor, WAY171318, reduced CCh-induced phosphorylation of ERK and completely blocked EGFr phosphorylation and TGF-alpha release.	Carbachol	50-53	mitogen-activated protein kinase 1	Homo sapiens	81-84
12202486-10	2002	We conclude that CCh-stimulated EGFr transactivation and subsequent ERK activation, a pathway that limits CCh-induced chloride secretion, is mediated by metalloproteinase-dependent extracellular release of TGF-alpha and intracellular Src activation.	Carbachol	17-20	epidermal growth factor receptor	Homo sapiens	32-36
12438084-10	2002	By contrast, while muscarine, nicotine, or carbachol (100 micro M) also evoke rapid increases in rat PNMT promoter activity, peak activity is observed at 6 hours, followed by a decline and restoration to basal levels by 24 hours.	Carbachol	43-52	phenylethanolamine-N-methyltransferase	Rattus norvegicus	101-105
12202486-10	2002	We conclude that CCh-stimulated EGFr transactivation and subsequent ERK activation, a pathway that limits CCh-induced chloride secretion, is mediated by metalloproteinase-dependent extracellular release of TGF-alpha and intracellular Src activation.	Carbachol	17-20	mitogen-activated protein kinase 1	Homo sapiens	68-71
12202486-10	2002	We conclude that CCh-stimulated EGFr transactivation and subsequent ERK activation, a pathway that limits CCh-induced chloride secretion, is mediated by metalloproteinase-dependent extracellular release of TGF-alpha and intracellular Src activation.	Carbachol	17-20	transforming growth factor alpha	Homo sapiens	206-215
12202486-10	2002	We conclude that CCh-stimulated EGFr transactivation and subsequent ERK activation, a pathway that limits CCh-induced chloride secretion, is mediated by metalloproteinase-dependent extracellular release of TGF-alpha and intracellular Src activation.	Carbachol	106-109	epidermal growth factor receptor	Homo sapiens	32-36
12202486-10	2002	We conclude that CCh-stimulated EGFr transactivation and subsequent ERK activation, a pathway that limits CCh-induced chloride secretion, is mediated by metalloproteinase-dependent extracellular release of TGF-alpha and intracellular Src activation.	Carbachol	106-109	mitogen-activated protein kinase 1	Homo sapiens	68-71
12149271-7	2002	We found that perfused Sur1 null pancreata secreted insulin in response to the cholinergic agonist carbachol in a glucose-dependent manner.	Carbachol	99-108	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	23-27
12223352-6	2002	However, whereas IFN-gamma significantly inhibited carbachol-induced Cl(-) secretion, neither neutralizing antibodies to TGF-alpha nor an EGFr inhibitor (1 microM tyrphostin AG 1478) were able to reverse this inhibitory effect.	Carbachol	51-60	interferon gamma	Homo sapiens	17-26
14566596-7	2002	Combination of CCh and ISP in different concentrations resulted in distinctive morphological changes which reflect fluid secretion and mucin secretion.	Carbachol	15-18	solute carrier family 13 member 2	Rattus norvegicus	135-140
12202486-0	2002	Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha.	Carbachol	87-96	epidermal growth factor receptor	Homo sapiens	23-55
12202486-0	2002	Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha.	Carbachol	87-96	tumor necrosis factor	Homo sapiens	131-163
12202486-1	2002	We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation.	Carbachol	54-63	epidermal growth factor receptor	Homo sapiens	90-122
12202486-1	2002	We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation.	Carbachol	54-63	epidermal growth factor receptor	Homo sapiens	124-128
12202486-1	2002	We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation.	Carbachol	54-63	protein tyrosine kinase 2 beta	Homo sapiens	146-151
12202486-1	2002	We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation.	Carbachol	65-68	epidermal growth factor receptor	Homo sapiens	90-122
12202486-1	2002	We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation.	Carbachol	65-68	epidermal growth factor receptor	Homo sapiens	124-128
12202486-1	2002	We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and Src kinase activation.	Carbachol	65-68	protein tyrosine kinase 2 beta	Homo sapiens	146-151
12202486-2	2002	EGFr phosphorylation causes extracellular signal-regulated kinase (ERK) activation and inhibits CCh-stimulated chloride secretion across intestinal epithelial cells.	Carbachol	96-99	epidermal growth factor receptor	Homo sapiens	0-4
12202486-3	2002	Here we investigated whether CCh-stimulated EGFr transactivation involves EGFr ligand release.	Carbachol	29-32	epidermal growth factor receptor	Homo sapiens	44-48
12202486-3	2002	Here we investigated whether CCh-stimulated EGFr transactivation involves EGFr ligand release.	Carbachol	29-32	epidermal growth factor receptor	Homo sapiens	74-78
12202486-4	2002	Pre-incubation of T(84) cell monolayers with a neutralizing antibody to the EGFr ligand binding domain decreased CCh-induced phosphorylation of EGFr and ERK.	Carbachol	113-116	epidermal growth factor receptor	Homo sapiens	76-80
12202486-4	2002	Pre-incubation of T(84) cell monolayers with a neutralizing antibody to the EGFr ligand binding domain decreased CCh-induced phosphorylation of EGFr and ERK.	Carbachol	113-116	epidermal growth factor receptor	Homo sapiens	144-148
12202486-4	2002	Pre-incubation of T(84) cell monolayers with a neutralizing antibody to the EGFr ligand binding domain decreased CCh-induced phosphorylation of EGFr and ERK.	Carbachol	113-116	mitogen-activated protein kinase 1	Homo sapiens	153-156
12202486-5	2002	CCh-stimulated efflux of (86)Rb+ from T(84) cell monolayers, which parallels changes in chloride secretion, was potentiated by anti-EGFr pre-incubation.	Carbachol	0-3	epidermal growth factor receptor	Homo sapiens	132-136
12202486-7	2002	Co-incubation with the Src kinase inhibitor PP2 and anti-EGFr had an additive inhibitory effect on CCh-induced ERK phosphorylation greater than either inhibitor alone.	Carbachol	99-102	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	44-47
12202486-7	2002	Co-incubation with the Src kinase inhibitor PP2 and anti-EGFr had an additive inhibitory effect on CCh-induced ERK phosphorylation greater than either inhibitor alone.	Carbachol	99-102	epidermal growth factor receptor	Homo sapiens	57-61
12202486-7	2002	Co-incubation with the Src kinase inhibitor PP2 and anti-EGFr had an additive inhibitory effect on CCh-induced ERK phosphorylation greater than either inhibitor alone.	Carbachol	99-102	mitogen-activated protein kinase 1	Homo sapiens	111-114
12202486-8	2002	CCh caused the basolateral release of transforming growth factor alpha (TGF-alpha) into T(84) cell bathing media.	Carbachol	0-3	tumor necrosis factor	Homo sapiens	38-70
12202486-8	2002	CCh caused the basolateral release of transforming growth factor alpha (TGF-alpha) into T(84) cell bathing media.	Carbachol	0-3	transforming growth factor alpha	Homo sapiens	72-81
12370534-0	2002	Regulation of carbachol-induced c-fos mRNA expression in AR42J cells by somatostatin receptor subtypes 1, 2, and 3.	Carbachol	14-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-37
12370534-0	2002	Regulation of carbachol-induced c-fos mRNA expression in AR42J cells by somatostatin receptor subtypes 1, 2, and 3.	Carbachol	14-23	somatostatin receptor 1	Rattus norvegicus	72-114
12370534-5	2002	When AR42J cells were exposed to the cholinergic agonist carbachol in the presence of somatostatin or selective SSTR agonists, significant and dose-dependent reductions in agonist-induced levels of mRNA were noted.	Carbachol	57-66	somatostatin receptor 3	Rattus norvegicus	112-116
12370534-9	2002	CONCLUSION: The current studies demonstrate that somatostatin inhibits carbachol-induced increases in expression by interacting with somatostatin receptor subtypes 1, 2, and 3.	Carbachol	71-80	somatostatin receptor 1	Rattus norvegicus	133-175
12121968-1	2002	We studied effects of the familial Alzheimer"s disease presenilin 1 (PS1) exon 9 deletion (PS1-DeltaE9) mutation on basal and carbachol-stimulated phosphoinositide (PI) hydrolysis and intracellular Ca(2+) concentrations ([Ca(2+)](i)) in human SH-SY5Y neuroblastoma cells.	Carbachol	126-135	presenilin 1	Homo sapiens	55-67
12121968-1	2002	We studied effects of the familial Alzheimer"s disease presenilin 1 (PS1) exon 9 deletion (PS1-DeltaE9) mutation on basal and carbachol-stimulated phosphoinositide (PI) hydrolysis and intracellular Ca(2+) concentrations ([Ca(2+)](i)) in human SH-SY5Y neuroblastoma cells.	Carbachol	126-135	presenilin 1	Homo sapiens	69-72
12121968-5	2002	Carbachol gave a greater stimulation of [Ca(2+)](i) in PS1-DeltaE9 cells that took longer to return to basal as compared with responses seen in NT and PS1-WT cells.	Carbachol	0-9	presenilin 1	Homo sapiens	55-58
12121968-6	2002	This long tail-off effect seen in PS1-DeltaE9 cells after carbachol stimulation was reversed by xestospongin C and dantrolene, suggesting that it was mediated by inositol trisphosphate receptor and ryanodine receptor amplification of Ca(2+).	Carbachol	58-67	presenilin 1	Homo sapiens	34-37
12372560-1	2002	Phase and amplitude depth profiles of EEG theta-like activity (TLA) induced by bath perfusion of 50 micro M of the cholinergic agonist carbachol were investigated using rat hippocampal formation slices.	Carbachol	135-144	RT1 class Ib, locus T18	Rattus norvegicus	63-66
12213302-0	2002	Neuropeptide Y potentiates the pressor response evoked by carbachol administration into the posterior hypothalamic nucleus of conscious rat.	Carbachol	58-67	neuropeptide Y	Rattus norvegicus	0-14
12213302-6	2002	Administration of 0.23 nmol of NPY 60 min prior to CCh induced a parallel shift to the left of the dose-response curves for CCh resulting in an increase in relative potency for CCh of 6.4 to 6.9 times.	Carbachol	51-54	neuropeptide Y	Rattus norvegicus	31-34
12213302-6	2002	Administration of 0.23 nmol of NPY 60 min prior to CCh induced a parallel shift to the left of the dose-response curves for CCh resulting in an increase in relative potency for CCh of 6.4 to 6.9 times.	Carbachol	124-127	neuropeptide Y	Rattus norvegicus	31-34
12213302-6	2002	Administration of 0.23 nmol of NPY 60 min prior to CCh induced a parallel shift to the left of the dose-response curves for CCh resulting in an increase in relative potency for CCh of 6.4 to 6.9 times.	Carbachol	124-127	neuropeptide Y	Rattus norvegicus	31-34
12213302-7	2002	This NPY-mediated enhancement was prevented by pretreatment with PYX-2 which alone did not affect the CCh-induced pressor response.	Carbachol	102-105	neuropeptide Y	Rattus norvegicus	5-8
12213302-8	2002	These results show that NPY enhances the pressor response evoked by CCh administration into the PHN of the conscious rat and that this enhancement is mediated by stimulation of a Y receptor.	Carbachol	68-71	neuropeptide Y	Rattus norvegicus	24-27
12231388-3	2002	PNU-171990 caused a parallel shift in the concentration-response curve for carbachol-induced contraction of smooth muscle from guinea pig bladder (pK(B), 7.65), guinea pig ileum (pK(B), 8.48), and human ileum (pK(B), 7.10).	Carbachol	75-84	AKT serine/threonine kinase 1	Homo sapiens	147-151
12231388-3	2002	PNU-171990 caused a parallel shift in the concentration-response curve for carbachol-induced contraction of smooth muscle from guinea pig bladder (pK(B), 7.65), guinea pig ileum (pK(B), 8.48), and human ileum (pK(B), 7.10).	Carbachol	75-84	AKT serine/threonine kinase 1	Homo sapiens	179-183
12231388-3	2002	PNU-171990 caused a parallel shift in the concentration-response curve for carbachol-induced contraction of smooth muscle from guinea pig bladder (pK(B), 7.65), guinea pig ileum (pK(B), 8.48), and human ileum (pK(B), 7.10).	Carbachol	75-84	AKT serine/threonine kinase 1	Homo sapiens	179-183
12128250-1	2002	The activation of muscle PKC isozymes following treatment with carbachol, an acetylcholine receptor agonist, has been investigated.	Carbachol	63-72	protein kinase C, alpha	Mus musculus	25-28
12369741-5	2002	The present study sought to determine 1) the functional selectivity of carbachol for cholinergic muscarinic and/or nicotinic receptors involved in the stimulation of HPA axis; 2) the involvement of prostaglandins (PGs) generated by constitutive and inducible cyclooxygenase (COX-1 and COX-2) in the carbachol-induced ACTH and corticosterone secretion in non-stressed rats and animals exposed to social crowding stress for 7 days (24 per a cage for 6).	Carbachol	71-80	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	275-280
12369741-5	2002	The present study sought to determine 1) the functional selectivity of carbachol for cholinergic muscarinic and/or nicotinic receptors involved in the stimulation of HPA axis; 2) the involvement of prostaglandins (PGs) generated by constitutive and inducible cyclooxygenase (COX-1 and COX-2) in the carbachol-induced ACTH and corticosterone secretion in non-stressed rats and animals exposed to social crowding stress for 7 days (24 per a cage for 6).	Carbachol	71-80	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	285-290
12369741-21	2002	), a COX-1 inhibitor, considerably impaired the carbachol-induced ACTH and corticosterone responses in control rats and markedly diminished these responses in stressed rats.	Carbachol	48-57	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	5-10
12369741-24	2002	These results indicate that in the carbachol-induced HPA axis activation PGs generated by COX-1 are considerably and to a much greater extent involved than PGs generated by COX-2.	Carbachol	35-44	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	90-95
12020766-8	2002	Pretreatment of the cells with PP2 markedly decreased Cch-induced ERK1/2 phosphorylation, suggesting a role of Src family of tyrosine kinases in the signal transduction pathway involved in ERK1/2 activation by mAChR.	Carbachol	54-57	mitogen activated protein kinase 3	Rattus norvegicus	66-72
12020766-8	2002	Pretreatment of the cells with PP2 markedly decreased Cch-induced ERK1/2 phosphorylation, suggesting a role of Src family of tyrosine kinases in the signal transduction pathway involved in ERK1/2 activation by mAChR.	Carbachol	54-57	mitogen activated protein kinase 3	Rattus norvegicus	189-195
12154174-0	2002	Carbachol triggers RyR-dependent Ca(2+) release via activation of IP(3) receptors in isolated rat gastric myocytes.	Carbachol	0-9	ryanodine receptor 2	Rattus norvegicus	19-22
11994295-5	2002	In vivo, the ratio of bound GDP/GTP and phosphorylation of annexin 7 change in direct proportion to the extent of catecholamine release from chromaffin cells in response to stimulation by carbachol, or to inhibition by various protein kinase C inhibitors.	Carbachol	188-197	annexin A7	Homo sapiens	59-68
12392895-3	2002	The response to the acetylcholine analogue, carbamylcholine, decreased from a 95+/-2% (+/-SEM, n=8) inhibition of beat rate in control cells to 18+/-2% (+/-SEM,n =8) in TGFbeta(1) treated cells.	Carbachol	44-59	transforming growth factor beta 1	Gallus gallus	169-179
12215855-9	2002	F, P and VIP most effectively reversed the carbachol-induced tension of isolated human detrusor strips.	Carbachol	43-52	vasoactive intestinal peptide	Homo sapiens	9-12
12136125-9	2002	Adenovirus-mediated transfer of MGL cDNA into rat cortical neurons increased MGL expression and attenuated N-methyl-D-aspartate/carbachol-induced 2-AG accumulation in these cells.	Carbachol	128-137	monoglyceride lipase	Rattus norvegicus	32-35
12020766-1	2002	Carbachol (Cch), a muscarinic acetylcholine receptors (mAChR) agonist, produces time- and dose-dependent increases in mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) phosphorylation in nondifferentiated Fischer rat thyroid (FRT) epithelial cells.	Carbachol	0-9	mitogen activated protein kinase 3	Rattus norvegicus	190-194
12020766-1	2002	Carbachol (Cch), a muscarinic acetylcholine receptors (mAChR) agonist, produces time- and dose-dependent increases in mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) phosphorylation in nondifferentiated Fischer rat thyroid (FRT) epithelial cells.	Carbachol	0-9	Eph receptor B1	Rattus norvegicus	195-198
12020766-1	2002	Carbachol (Cch), a muscarinic acetylcholine receptors (mAChR) agonist, produces time- and dose-dependent increases in mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) phosphorylation in nondifferentiated Fischer rat thyroid (FRT) epithelial cells.	Carbachol	11-14	mitogen activated protein kinase 3	Rattus norvegicus	190-194
12020766-1	2002	Carbachol (Cch), a muscarinic acetylcholine receptors (mAChR) agonist, produces time- and dose-dependent increases in mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) phosphorylation in nondifferentiated Fischer rat thyroid (FRT) epithelial cells.	Carbachol	11-14	Eph receptor B1	Rattus norvegicus	195-198
12020766-2	2002	Cells pretreatment with the selective phospholipase C inhibitor U73122 resulted in a decrease of Cch-stimulated ERK1/2 phosphorylation.	Carbachol	97-100	mitogen activated protein kinase 3	Rattus norvegicus	112-118
12020766-6	2002	Additionally, Cch-induced ERK1/2 phosphorylation was reduced after either inhibition of Ca(2+) influx or intracellular Ca(2+) release.	Carbachol	14-17	mitogen activated protein kinase 3	Rattus norvegicus	26-32
12020766-7	2002	Nevertheless, Cch-mediated ERK1/2 activation was genistein sensitive, indicating the involvement of protein tyrosine kinases on the downstream signalling of mAChR.	Carbachol	14-17	mitogen activated protein kinase 3	Rattus norvegicus	27-33
12011082-0	2002	Effects of glucose, exogenous insulin, and carbachol on C-peptide and insulin secretion from isolated perifused rat islets.	Carbachol	43-52	insulin	Homo sapiens	70-77
12011082-6	2002	Stimulation with carbachol plus 7 mm glucose enhanced both C-peptide and insulin secretion, and the further addition of 100 nm bovine insulin had no inhibitory effect on C-peptide secretory rates under this condition.	Carbachol	17-26	insulin	Bos taurus	73-80
12006602-5	2002	RGS3 and RGS5 ribozymes differentially enhanced carbachol- and angiotensin II-induced MAP kinase activity, respectively, whereas RGS2 and RGS7 ribozymes had no effect.	Carbachol	48-57	regulator of G-protein signaling 3	Rattus norvegicus	0-4
12006602-5	2002	RGS3 and RGS5 ribozymes differentially enhanced carbachol- and angiotensin II-induced MAP kinase activity, respectively, whereas RGS2 and RGS7 ribozymes had no effect.	Carbachol	48-57	regulator of G-protein signaling 5	Rattus norvegicus	9-13
12006602-9	2002	These results indicate the feasibility of using the ribozyme technology to determine the functional role of endogenous RGS proteins in signaling pathways and to define novel receptor-selective roles of endogenous RGS3 and RGS5 in modulating MAP kinase responses to either carbachol or angiotensin.	Carbachol	272-281	regulator of G-protein signaling 3	Rattus norvegicus	213-217
12006602-9	2002	These results indicate the feasibility of using the ribozyme technology to determine the functional role of endogenous RGS proteins in signaling pathways and to define novel receptor-selective roles of endogenous RGS3 and RGS5 in modulating MAP kinase responses to either carbachol or angiotensin.	Carbachol	272-281	regulator of G-protein signaling 5	Rattus norvegicus	222-226
12110618-6	2002	Inhibition of PKC-alpha by the indolocarbazole Go 6976 revealed that about 28% of carbachol-induced acid secretion was inhibited by PKC-alpha.	Carbachol	82-91	protein kinase C alpha	Homo sapiens	14-23
12110618-6	2002	Inhibition of PKC-alpha by the indolocarbazole Go 6976 revealed that about 28% of carbachol-induced acid secretion was inhibited by PKC-alpha.	Carbachol	82-91	protein kinase C alpha	Homo sapiens	132-141
12110618-7	2002	In the presence of Go 6976 approximately 64% of the carbachol-induced signal transduction is mediated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), and 14% is conveyed by PKC-epsilon as deduced from the inhibition with the bisindolylmaleimide Ro 31-8220.	Carbachol	52-61	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	105-150
12110618-7	2002	In the presence of Go 6976 approximately 64% of the carbachol-induced signal transduction is mediated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), and 14% is conveyed by PKC-epsilon as deduced from the inhibition with the bisindolylmaleimide Ro 31-8220.	Carbachol	52-61	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	152-158
12110618-9	2002	Inhibition of carbachol-induced acid secretion by TPA was accompanied by a decrease in CaMKII activity.	Carbachol	14-23	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	87-93
12091463-0	2002	Effect of ethanol on protein kinase Czeta and p70S6 kinase activation by carbachol: a possible mechanism for ethanol-induced inhibition of glial cell proliferation.	Carbachol	73-82	ribosomal protein S6 kinase B1	Homo sapiens	46-58
12091463-2	2002	In this study we investigated the activation of p70S6 kinase (p70S6K) by carbachol in 1321 N1 astroctyoma cells.	Carbachol	73-82	ribosomal protein S6 kinase B1	Homo sapiens	48-60
12091463-2	2002	In this study we investigated the activation of p70S6 kinase (p70S6K) by carbachol in 1321 N1 astroctyoma cells.	Carbachol	73-82	ribosomal protein S6 kinase B1	Homo sapiens	62-68
12091463-3	2002	Carbachol induced a dose- and time-dependent activation of p70S6K, as evidenced by increased phosphorylation at Thr-389, Thr-421 and Ser-424, by increased p70S6K activity, and by a shift in its molecular weight.	Carbachol	0-9	ribosomal protein S6 kinase B1	Homo sapiens	59-65
12091463-3	2002	Carbachol induced a dose- and time-dependent activation of p70S6K, as evidenced by increased phosphorylation at Thr-389, Thr-421 and Ser-424, by increased p70S6K activity, and by a shift in its molecular weight.	Carbachol	0-9	ribosomal protein S6 kinase B1	Homo sapiens	155-161
12091463-5	2002	Carbachol-induced DNA synthesis was strongly inhibited by rapamycin, suggesting that p70S6K activation plays an important role in carbachol-induced cell proliferation.	Carbachol	0-9	ribosomal protein S6 kinase B1	Homo sapiens	85-91
12091463-5	2002	Carbachol-induced DNA synthesis was strongly inhibited by rapamycin, suggesting that p70S6K activation plays an important role in carbachol-induced cell proliferation.	Carbachol	130-139	ribosomal protein S6 kinase B1	Homo sapiens	85-91
12091463-7	2002	In the same range of concentrations, ethanol also inhibits carbachol-induced activation of PKCzeta and of p70S6K.	Carbachol	59-68	protein kinase C zeta	Homo sapiens	91-98
12091463-7	2002	In the same range of concentrations, ethanol also inhibits carbachol-induced activation of PKCzeta and of p70S6K.	Carbachol	59-68	ribosomal protein S6 kinase B1	Homo sapiens	106-112
12124440-2	2002	In SK-N-SH neuroblastoma cells, treatment with the cholinergic agonist carbachol led to maximal induction of EGR1 1 h after stimulation.	Carbachol	71-80	early growth response 1	Homo sapiens	109-113
12124440-3	2002	This was preceded by the phosphorylation of CREB, which peaked as early as 5 minutes after carbachol treatment.	Carbachol	91-100	cAMP responsive element binding protein 1	Homo sapiens	44-48
12124440-4	2002	The levels of both EGR1 and phosphorylated CREB (pCREB) slowly decayed over 4-8 h. CREB phosphorylation and EGR1 induction showed similar sensitivity to carbachol concentration, with EC(50) values in the range of 1-10 microM, and the changes in both transcription factors were blocked by the muscarinic antagonist atropine.	Carbachol	153-162	cAMP responsive element binding protein 1	Homo sapiens	43-47
12124440-4	2002	The levels of both EGR1 and phosphorylated CREB (pCREB) slowly decayed over 4-8 h. CREB phosphorylation and EGR1 induction showed similar sensitivity to carbachol concentration, with EC(50) values in the range of 1-10 microM, and the changes in both transcription factors were blocked by the muscarinic antagonist atropine.	Carbachol	153-162	cAMP responsive element binding protein 1	Homo sapiens	50-54
12124440-4	2002	The levels of both EGR1 and phosphorylated CREB (pCREB) slowly decayed over 4-8 h. CREB phosphorylation and EGR1 induction showed similar sensitivity to carbachol concentration, with EC(50) values in the range of 1-10 microM, and the changes in both transcription factors were blocked by the muscarinic antagonist atropine.	Carbachol	153-162	early growth response 1	Homo sapiens	108-112
12124440-6	2002	However, CREB phosphorylation by carbachol was largely unaffected by MAP kinase blockade.	Carbachol	33-42	cAMP responsive element binding protein 1	Homo sapiens	9-13
12184734-5	2002	Next, we determined the effects of toluene on carbamylcholine-stimulated [35S]GTPgammaS binding using membrane fractions of CHO cell expressing hm2 receptors.	Carbachol	46-61	cholinergic receptor muscarinic 2	Homo sapiens	144-147
12128250-3	2002	Carbachol treatment resulted in a rapid translocation of PKC-theta; to the membrane.	Carbachol	0-9	protein kinase C, theta	Mus musculus	57-66
12128250-6	2002	The regulation of PKC-alpha in response to carbachol was quite distinct from that produced by the PKC activator, PMA, which rapidly translocated PKC-alpha from the cytosol to the membrane without any increases in PKC-alpha in the cytosol.	Carbachol	43-52	protein kinase C, alpha	Mus musculus	18-27
12128250-6	2002	The regulation of PKC-alpha in response to carbachol was quite distinct from that produced by the PKC activator, PMA, which rapidly translocated PKC-alpha from the cytosol to the membrane without any increases in PKC-alpha in the cytosol.	Carbachol	43-52	protein kinase C, alpha	Mus musculus	18-21
12128250-7	2002	Confocal microscopy demonstrated an enhanced membrane localization of PKC-theta; and overall increased intensity of PKC-alpha staining in the cytosol accompanied by a characteristic membrane staining of PKC-alpha in the myotubes treated with carbachol.	Carbachol	242-251	protein kinase C, theta	Mus musculus	70-79
12128250-7	2002	Confocal microscopy demonstrated an enhanced membrane localization of PKC-theta; and overall increased intensity of PKC-alpha staining in the cytosol accompanied by a characteristic membrane staining of PKC-alpha in the myotubes treated with carbachol.	Carbachol	242-251	protein kinase C, alpha	Mus musculus	116-125
12128250-7	2002	Confocal microscopy demonstrated an enhanced membrane localization of PKC-theta; and overall increased intensity of PKC-alpha staining in the cytosol accompanied by a characteristic membrane staining of PKC-alpha in the myotubes treated with carbachol.	Carbachol	242-251	protein kinase C, alpha	Mus musculus	203-212
12016133-3	2002	Carbachol was the most potent inducer of COX-2 gene expression.	Carbachol	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
12106807-4	2002	The PAR-2-activating peptide SLIGRL-NH(2), but not the inactive control peptide, when administered i.v., strongly suppressed gastric acid secretion in response to carbachol, pentagastrin or 2-deoxy-D-glucose in the rats with a pylorus ligation.	Carbachol	163-172	F2R like trypsin receptor 1	Rattus norvegicus	4-9
12011984-5	2002	The nitric oxide synthase (NOS) inhibitor, NGmono-methyl-L-arginine (L-NMMA), blunted this effect only in LM3 cells while in LM2 cells the action of CARB was blocked by Nomega hydroxy-L-arginine (L-OH-Arg), which is known to inhibit the arginase pathway.	Carbachol	149-153	nitric oxide synthase 1, neuronal	Mus musculus	4-25
12016133-8	2002	Addition of SB-203580 with Ad.dom.neg.IkappaB almost completely blocked carbachol stimulation of COX-2 gene expression.	Carbachol	72-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
12016133-12	2002	Selective COX-2 inhibitor NS-398 blocked carbachol-stimulated PGE(2) release without affecting basal PGE(2) production.	Carbachol	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
12016133-14	2002	Carbachol induces COX-2 gene expression in the parietal cells through signaling pathways that involve intracellular Ca(2+), PKC, p38 kinase, and activation of NF-kappaB.	Carbachol	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
12016133-14	2002	Carbachol induces COX-2 gene expression in the parietal cells through signaling pathways that involve intracellular Ca(2+), PKC, p38 kinase, and activation of NF-kappaB.	Carbachol	0-9	nuclear factor kappa B subunit 1	Homo sapiens	159-168
11939793-5	2002	The basal and carbachol-stimulated shedding of APP and ACE from human SH-SY5Y neuroblastoma cells could not be differentiated by any of the hydroxamate compounds, implying that the same or very similar activities are involved in the constitutive and regulated shedding of these two proteins.	Carbachol	14-23	angiotensin I converting enzyme	Homo sapiens	55-58
11961129-7	2002	Activation by carbachol of endogenously expressed M(1) muscarinic receptors in human embryonic kidney 293 cells, induced the internalization of mGluR1 splice variants, which was partially blocked by pretreatment with inhibitors of either PKC or Ca(2+) calmodulin-dependent kinase II (CaMKII).	Carbachol	14-23	glutamate metabotropic receptor 1	Homo sapiens	144-150
11961129-7	2002	Activation by carbachol of endogenously expressed M(1) muscarinic receptors in human embryonic kidney 293 cells, induced the internalization of mGluR1 splice variants, which was partially blocked by pretreatment with inhibitors of either PKC or Ca(2+) calmodulin-dependent kinase II (CaMKII).	Carbachol	14-23	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	284-290
11961129-10	2002	In addition, arrestin-2-GFP or arrestin-3-GFP underwent significant carbachol-induced translocation from cytosol to membrane in cells coexpressing mGluR1a or 1c but not in cells coexpressing mGluR1b.	Carbachol	68-77	arrestin beta 1	Homo sapiens	13-23
11961129-10	2002	In addition, arrestin-2-GFP or arrestin-3-GFP underwent significant carbachol-induced translocation from cytosol to membrane in cells coexpressing mGluR1a or 1c but not in cells coexpressing mGluR1b.	Carbachol	68-77	arrestin 3	Homo sapiens	31-41
12398158-3	2002	Among several spasmogens, neurokinin A was the most potent with the following order of potency: carbachol, prostaglandin F2alpha and acetylcholine.	Carbachol	96-105	tachykinin precursor 1	Homo sapiens	26-38
11830588-0	2002	The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.	Carbachol	48-57	transient receptor potential cation channel subfamily C member 4	Homo sapiens	29-33
11830588-4	2002	Expression of HTRP4 antisense inhibited 35% of the carbachol (CCh)-stimulated Ba(2+) entry and 46% of the OAG-stimulated Sr(2+) entry but in contrast had no effect on the thapsigargin-stimulated Ba(2+) or Sr(2+) entry.	Carbachol	51-60	transient receptor potential cation channel subfamily C member 4	Homo sapiens	14-19
11830588-4	2002	Expression of HTRP4 antisense inhibited 35% of the carbachol (CCh)-stimulated Ba(2+) entry and 46% of the OAG-stimulated Sr(2+) entry but in contrast had no effect on the thapsigargin-stimulated Ba(2+) or Sr(2+) entry.	Carbachol	62-65	transient receptor potential cation channel subfamily C member 4	Homo sapiens	14-19
11830588-6	2002	Of greater importance, HTRP4 antisense expression, but not HTRP3 antisense expression, blocked the sustained Ca(2+) oscillations produced by low doses of CCh (15 microm), arguing that receptor-stimulated rather than store-operated channels are involved in these sustained oscillations.	Carbachol	154-157	transient receptor potential cation channel subfamily C member 4	Homo sapiens	23-28
11830588-8	2002	In summary, these data suggest that HTRP4 proteins in HEK-293 cells, differing from HTRP3 and HTRP1 proteins, do not serve as functional subunits of store-operated channels but do function as subunits for CCh- and OAG-stimulated channels.	Carbachol	205-208	transient receptor potential cation channel subfamily C member 4	Homo sapiens	36-41
11965549-5	2002	Carbachol-mediated release of Ca(2+) from intracellular stores was significantly higher in Bax transfectants compared to control transfectants (empty vector).	Carbachol	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94
12167246-5	2002	Whereas the cholinergic agonist, carbachol, impairs traffic from the trans-Golgi network to prelysosomes, causing Golgi, secretory, and lysosomal proteins to reflux into domains of the trans-Golgi network that communicate with the blm and to accumulate in the blm, EGF specifically causes a 2.6-fold (P &lt; 0.05) increase in the beta-hexosaminidase content of the blm fraction, apparently by impairing traffic from early endosomes to prelysosome.	Carbachol	33-42	O-GlcNAcase	Homo sapiens	330-349
11830588-9	2002	Furthermore, evidence is provided for the first time for the involvement of a Trp isoform (HTRP4) in the formation of the channel responsible for both arachidonic acid-induced Ca(2+) entry and the Ca(2+) entry needed to sustain long term Ca(2+) oscillations induced by low doses of carbachol.	Carbachol	282-291	transient receptor potential cation channel subfamily C member 4	Homo sapiens	91-96
11805119-8	2002	In comparison with untransfected cells depletion of intracellular calcium stores in hTRP7-expressing cells, using either carbachol or thapsigargin, produced a marked increase in the subsequent level of Ca(2+) influx.	Carbachol	121-130	transient receptor potential cation channel subfamily C member 7	Homo sapiens	84-89
12148843-8	2002	We found that around two-thirds of cells tested still showed some swelling-induced Ca2+ release (SICR) even after maximal concentrations (10(-5) M - 10(-4) M) of carbachol had been applied to empty agonist-sensitive intracellular Ca2+ stores.	Carbachol	162-171	carbonic anhydrase 2	Rattus norvegicus	230-233
11832335-8	2002	Stimulated fluid production by the glands from Cx32-deficient mice was abnormally low in female glands compared with controls at low topical doses of carbachol.	Carbachol	150-159	gap junction protein, beta 1	Mus musculus	47-51
11982704-7	2002	RESULTS: Endothelin-3 induced a concentration-dependent increase in tone in both human and pos-sum strips (P &lt; 0.05) and at 100 nmol/L represented 44.2 +/- 4.5% and 40.3 +/- 4.6% of carbachol-induced tone, respectively.	Carbachol	185-194	endothelin 3	Homo sapiens	9-21
11714707-3	2002	Applying carbachol to the contralateral hippocampal slices from ischemic rats increased the phosphorylation of ERK1/2 but did not increase phosphorylation in the ipsilateral hippocampus.	Carbachol	9-18	mitogen activated protein kinase 3	Rattus norvegicus	111-117
11714707-8	2002	Carbachol-stimulated tyrosine phosphorylation of the G alpha(q/11), inositol 1,4,5-trisphosphate formation, and association of G alpha(q/11) with phospholipase C beta 1 were attenuated in the ipsilateral hippocampus.	Carbachol	0-9	phospholipase C beta 1	Rattus norvegicus	146-168
11804843-7	2002	Incubation of longitudinal muscle-myenteric plexus (LMMP) with IL-4 and IL-13 enhanced Carbachol-induced muscle contraction (R(max) 35.5 +/- 1.9 and 32.4 +/- 2.9%, respectively).	Carbachol	87-96	interleukin 4	Mus musculus	63-67
11812654-8	2002	The sensitivity to guanosine 5"-[gamma-thio]trisphosphate (GTP-gamma-S) and carbachol stimulation of PLC-beta1 activity was increased by PA.	Carbachol	76-85	phospholipase C beta 1	Homo sapiens	101-110
11889209-8	2002	Disruption of GJ communication of GCs is probably due to increased phosphorylation of connexin 43 at serine residues, as shown in immunoprecipitation experiments with carbachol-challenged GCs.	Carbachol	167-176	gap junction protein alpha 1	Homo sapiens	86-97
11804843-7	2002	Incubation of longitudinal muscle-myenteric plexus (LMMP) with IL-4 and IL-13 enhanced Carbachol-induced muscle contraction (R(max) 35.5 +/- 1.9 and 32.4 +/- 2.9%, respectively).	Carbachol	87-96	interleukin 13	Mus musculus	72-77
11834435-6	2002	RESULTS: Addition of 10 nM ghrelin to the perfusate significantly reduced the insulin response to the secretagogues glucose, arginine and carbachol, which act on the B-cell via different mechanisms, as well as the somatostatin response to arginine.	Carbachol	138-147	ghrelin and obestatin prepropeptide	Rattus norvegicus	27-34
11882609-8	2002	Stimulation of PKC by other means, such as phorbol-12-myristate-13-acetate or carbachol, also resulted in the redistribution of fluorescence in a manner similar to that observed for angiotensin II.	Carbachol	78-87	protein kinase C beta	Homo sapiens	15-18
11818389-14	2002	CONCLUSIONS: These results suggest that pretreatment of cultured rat retinal neurons with ACh or the nAChR agonists, nicotine and carbachol, has a protective action against glutamate neurotoxicity through nAChRs and that the dopamine release induced by nicotinic stimulation subsequently protects the retinal neurons by way of dopamine D1 receptors.	Carbachol	130-139	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	101-106
11821019-4	2002	hP2X3 receptor desensitization was reversible and was not observed following the increase in intracellular Ca2+ levels produced by carbachol.	Carbachol	131-140	purinergic receptor P2X 3	Homo sapiens	0-5
11790384-4	2002	In distal common bile duct, indomethacin (5.6 microM) unmasked potent contractile effects of endothelin-1 [EC(50) 7.8 (5.5-11.1) nM; E(MAX) 80+/-6% of response to 80 mM KCl] and enhanced the contractile potency of carbachol (585-fold at EC(50) level), but not cholecystokinin C-terminal octapeptide.	Carbachol	214-223	endothelin-1	Cavia porcellus	93-105
11790384-3	2002	At 100 nM, endothelin-1 or sarafotoxin S6c (selective endothelin ET(B) receptor agonist) inhibited contractions of choledochal (but not papillary) sphincter of Oddi to carbachol (1 microM) by 63+/-5 and 45+/-9%, respectively.	Carbachol	168-177	endothelin-1	Cavia porcellus	11-23
11673466-3	2002	The stimulation of the cells by carbachol initiated the translocation of green fluorescent protein-tagged wild type RhoA to the plasma membrane within a minute.	Carbachol	32-41	ras homolog family member A	Homo sapiens	116-120
11804848-4	2002	Carbamylcholine chloride (Carbachol, CCh), A-23187, and thapsigargin also inhibited eIF2B and protein synthesis, whereas bombesin and the CCK analog JMV-180 were without effect.	Carbachol	0-24	eukaryotic translation initiation factor 2B subunit delta	Rattus norvegicus	84-89
11804848-4	2002	Carbamylcholine chloride (Carbachol, CCh), A-23187, and thapsigargin also inhibited eIF2B and protein synthesis, whereas bombesin and the CCK analog JMV-180 were without effect.	Carbachol	26-35	eukaryotic translation initiation factor 2B subunit delta	Rattus norvegicus	84-89
11673466-4	2002	The change in MLC20 phosphorylation level after carbachol stimulation was monitored by using phospho-Ser-19-specific antibody recognizing the phosphorylated MLC20 in single cells.	Carbachol	48-57	myosin light chain 12B	Homo sapiens	14-19
12613913-0	2002	Prolactin inhibits carbachol-dependent secretion by lacrimal acinar cells in vitro.	Carbachol	19-28	prolactin	Homo sapiens	0-9
11673466-4	2002	The change in MLC20 phosphorylation level after carbachol stimulation was monitored by using phospho-Ser-19-specific antibody recognizing the phosphorylated MLC20 in single cells.	Carbachol	48-57	myosin light chain 12B	Homo sapiens	157-162
11673466-7	2002	Carbachol stimulation increased myosin phosphorylation within a minute both at the cortical and the central region.	Carbachol	0-9	myosin heavy chain 14	Homo sapiens	32-38
12201629-3	2002	In the present study, we show that activation of synaptic inputs within and to the medial entorhinal cortex (mEC) of the in vitro isolated guinea pig brain preparation resets the phase of ongoing gamma activity induced by muscarinic receptor agonism with carbachol (frequency: 24 +/- 2 Hz at 32 degrees C).	Carbachol	255-264	chemokine (C-C motif) ligand 28	Mus musculus	109-112
11780929-4	2002	Combined intracavernosal carbachol administration and submaximal CN electrical stimulation raised the recorded ICP, elicited by CN electrical stimulation alone in wild-type mice (from 35.7 +/- 2.7 to 48.1 +/- 5.5 mm Hg, P &lt; .05) but not in eNOS-/ - mice (from 54.9 +/- 6.3 to 51.0 +/- 9.5 mm Hg, not significant [NS]).	Carbachol	25-34	nitric oxide synthase 3, endothelial cell	Mus musculus	243-247
11679428-6	2001	The effects of phorbol ester, CCh, and CCK were inhibited by as much as 75% by the PKC inhibitors GF 109203X and Ro-32-0432 and after PKC downregulation.	Carbachol	30-33	protein kinase C, gamma	Rattus norvegicus	83-86
14517621-10	2002	CCh-induced IP(1) accumulation was potentiated significantly by NE and Phe, but not by DA.	Carbachol	0-3	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	12-17
14517621-11	2002	CONCLUSION: Although NE and Phe potentiated CCh-induced IP(1) accumulation, they could not potentiate CCh-induced contraction, suggesting that in clinical settings, vasopressors such as NE, DA, and Phe might be safely used in patients with asthma.	Carbachol	44-47	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	56-61
11755214-3	2001	Carbachol-stimulated increases in endogenous RGS2 protein levels appeared by immunocytochemical analysis to be largely confined to the nucleus, and this localization was confirmed by Western blot analysis which showed increased nuclear, but not cytosolic, RGS2 after carbachol treatment.	Carbachol	0-9	regulator of G protein signaling 2	Homo sapiens	256-260
11755214-3	2001	Carbachol-stimulated increases in endogenous RGS2 protein levels appeared by immunocytochemical analysis to be largely confined to the nucleus, and this localization was confirmed by Western blot analysis which showed increased nuclear, but not cytosolic, RGS2 after carbachol treatment.	Carbachol	267-276	regulator of G protein signaling 2	Homo sapiens	45-49
11590149-5	2001	We show that following carbachol stimulation, m4 co-localizes with transferrin, and the selective marker of early endosomes, EEA1.	Carbachol	23-32	transferrin	Homo sapiens	67-78
11590149-5	2001	We show that following carbachol stimulation, m4 co-localizes with transferrin, and the selective marker of early endosomes, EEA1.	Carbachol	23-32	early endosome antigen 1	Homo sapiens	125-129
11546796-6	2001	In addition, cleavage of ROCK-I was observed when cells overexpressing m1 muscarinic acetylcholine receptors were stimulated with carbachol.	Carbachol	130-139	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	25-31
11694521-3	2002	In support of this, carbachol increased PI 3-kinase activity in PI 3-kinase (p85) immunoprecipitates.	Carbachol	20-29	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	77-80
11927149-7	2002	Intracellular injection of the IP(3) receptor blocker heparin prevented both the mAchR-mediated occurrence of IP(3)-assisted CICR and enhancement of spike-frequency adaptation with 10 microM carbachol.	Carbachol	191-200	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	31-45
11755214-2	2001	In human astrocytoma 1321N1 cells RGS2 expression was increased by activation of muscarinic receptors coupled to phosphoinositide signaling with carbachol, or by increased cyclic AMP production, demonstrating that both signaling systems can increase the expression of a RGS family member in a single cell type.	Carbachol	145-154	regulator of G protein signaling 2	Homo sapiens	34-38
11755214-2	2001	In human astrocytoma 1321N1 cells RGS2 expression was increased by activation of muscarinic receptors coupled to phosphoinositide signaling with carbachol, or by increased cyclic AMP production, demonstrating that both signaling systems can increase the expression of a RGS family member in a single cell type.	Carbachol	145-154	paired like homeodomain 2	Homo sapiens	34-37
11755214-3	2001	Carbachol-stimulated increases in endogenous RGS2 protein levels appeared by immunocytochemical analysis to be largely confined to the nucleus, and this localization was confirmed by Western blot analysis which showed increased nuclear, but not cytosolic, RGS2 after carbachol treatment.	Carbachol	0-9	regulator of G protein signaling 2	Homo sapiens	45-49
11679428-6	2001	The effects of phorbol ester, CCh, and CCK were inhibited by as much as 75% by the PKC inhibitors GF 109203X and Ro-32-0432 and after PKC downregulation.	Carbachol	30-33	protein kinase C, gamma	Rattus norvegicus	134-137
12086906-6	2001	CCh induced time-and dose-dependent increases in the c-fos and c-jun early-response genes, which were blocked by m1 and m3 inhibition but not by m2 inhibition.	Carbachol	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-58
11679428-9	2001	Stringent Ca(2+) depletion by removal of extracellular Ca(2+) and inclusion of BAPTA/AM allowed for increased cAMP production in response to CCh and CCK; PKC inhibitors and PKC downregulation prevented this stimulation.	Carbachol	141-144	protein kinase C, gamma	Rattus norvegicus	154-157
11606435-10	2001	Furthermore, gel shift assays indicated that carbachol also induced a time-dependent stimulation of the activator protein-1 DNA-binding activity, suggesting that activation of mAChRs may play a role in the modulation of gene expression in Sertoli cells.	Carbachol	45-54	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	104-123
11922142-3	2001	The cholinergic agonist carbachol caused an atropine-sensitive ERK activation in the dendrites and somata CA1 pyramidal neurons.	Carbachol	24-33	mitogen-activated protein kinase 1	Mus musculus	63-66
11922142-3	2001	The cholinergic agonist carbachol caused an atropine-sensitive ERK activation in the dendrites and somata CA1 pyramidal neurons.	Carbachol	24-33	carbonic anhydrase 1	Mus musculus	106-109
11517225-2	2001	Transient and okadaic acid-sensitive inhibition by 70-85% of Ins(1,4,5)P(3) and Ins(1,3,4,5)P(4) 5-phosphatase activities was observed in homogenates from rat cortical astrocytes, human astrocytoma 1321N1 cells, and rat basophilic leukemia RBL-2H3 cells after incubation with carbachol.	Carbachol	276-285	insulin 1	Rattus norvegicus	80-110
11557526-9	2001	However, Ht31, but not Ht31P, inhibited carbachol- and A23187-stimulated augmentation of secretion from cells preincubated with cholera toxin.	Carbachol	40-49	A-kinase anchoring protein 13	Homo sapiens	9-13
11557586-3	2001	Forskolin-induced adenylyl cyclase activity was inhibited by carbachol in GGTI-2147-pretreated cells, demonstrating that the effect of geranylgeranyltransferase I inhibition on stress fiber formation was not due to uncoupling of signaling between the heterotrimeric G(i) protein (the Ggamma subunit is isoprenylated) and distal effectors.	Carbachol	61-70	protein geranylgeranyltransferase type I subunit beta	Homo sapiens	74-78
11846996-3	2001	AChR function measured by carbachol-induced (22)Na+ influx demonstrated that dimethoate may inhibit the nAChR function either by binding to a noncompetitive site and changing the conformational state of nAChR or by blocking the nAChR channel directly.	Carbachol	26-35	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	104-109
11559781-11	2001	In PLB-SMOE bladders, in contrast, the response of [Ca2+]i and force to CCh was significantly increased and the EC50 values were decreased.	Carbachol	72-75	phospholamban	Mus musculus	3-6
11420052-9	2001	CCh also caused a dose-dependent increase in [Ca2+]i measured by fura-2 in microspectrofluorimetric studies, with a half-maximal response at approximately 3x10(-6) M. Neither isoproterenol (10(-5) M) nor substance P (10(-6) M) affected K+-channel activity or [Ca2+]i.	Carbachol	0-3	tachykinin precursor 1	Homo sapiens	204-215
11564718-5	2001	Nutrients, such as palmitic acid, oleic acid, and meat hydrolysate, stimulated GLP-1 secretion in a dose-dependent manner, as did the cholinergic agonist carbachol and the neuromediator gastrin-releasing peptide.	Carbachol	154-163	glucagon	Homo sapiens	79-84
11533128-8	2001	The physiological concentration of secretin (50 pM) had a relatively weak effect on I(Ks) (160 % increase), which was significantly enhanced by transient co-stimulation with carbachol (CCh) (10 microM).	Carbachol	174-183	secretin	Rattus norvegicus	35-43
11533128-8	2001	The physiological concentration of secretin (50 pM) had a relatively weak effect on I(Ks) (160 % increase), which was significantly enhanced by transient co-stimulation with carbachol (CCh) (10 microM).	Carbachol	185-188	secretin	Rattus norvegicus	35-43
11443064-11	2001	Carbachol (100 microM) translocated only PKC epsilon and inhibited I(sc) with no effect on TER.	Carbachol	0-9	protein kinase C epsilon	Homo sapiens	41-52
11509335-0	2001	Interleukin-4 rapidly inhibits calcium transients in response to carbachol in bovine airway smooth muscle cells.	Carbachol	65-74	interleukin 4	Bos taurus	0-13
11600318-4	2001	The effect of carbamylcholine was abolished by 10 microM BAPTA-AM (an intracellular Ca2+ chelator), 30 microM dantrolene (an inhibitor of ryanodinic receptors), 500 nM H-89 (an inhibitor of PKA), 1.25 microM chelerythrine chloride (an inhibitor of PKC) and 50 microM PD-98059 (a MEK inhibitor).	Carbachol	14-29	mitogen-activated protein kinase kinase 7	Homo sapiens	279-282
11470473-4	2001	Dialyzed (30-100 microM) ODQ (1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one), a soluble guanylyl cyclase (sGC) inactivator, blocked inhibition of IBMX-stimulated I(Ca(L)) by SIN-1 (10 microM) but not by CCh (1-100 microM) or ANP (100 nM).	Carbachol	201-204	sarcoglycan beta	Homo sapiens	104-107
11470473-4	2001	Dialyzed (30-100 microM) ODQ (1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one), a soluble guanylyl cyclase (sGC) inactivator, blocked inhibition of IBMX-stimulated I(Ca(L)) by SIN-1 (10 microM) but not by CCh (1-100 microM) or ANP (100 nM).	Carbachol	201-204	MAPK associated protein 1	Homo sapiens	172-177
11470473-6	2001	Thus CCh can increase cGMP synthesis via pGC.	Carbachol	5-8	progastricsin	Homo sapiens	41-44
11569612-3	2001	NOR 1, NO donor, relaxed the longitudinal muscle of the rat proximal colon, which was precontracted by carbachol, with a concomitant decrease in [Ca2+].	Carbachol	103-112	nuclear receptor subfamily 4 group A member 3	Homo sapiens	0-5
11460267-3	2001	Carbachol caused a rapid and transient phorphorylation of MAPK (ERK1/2) in all cell types, with an increase in MAPK activity, without changing the levels of MAPK proteins.	Carbachol	0-9	mitogen-activated protein kinase 3	Homo sapiens	64-70
11460267-6	2001	Pretreatment of cells with the protein kinase C (PKC) inhibitor bisindolylmaleimide I, or downregulation of PKC by 24-h treatment with the phorbol ester TPA inhibited carbachol-induced MAPK activation.	Carbachol	167-176	protein kinase C alpha	Homo sapiens	49-52
11460267-6	2001	Pretreatment of cells with the protein kinase C (PKC) inhibitor bisindolylmaleimide I, or downregulation of PKC by 24-h treatment with the phorbol ester TPA inhibited carbachol-induced MAPK activation.	Carbachol	167-176	protein kinase C alpha	Homo sapiens	108-111
11460267-7	2001	Additional experiments with PKC alpha- or PKC epsilon-specific compounds indicated that the epsilon isozyme of PKC is primarily involved in MAPK activation by carbachol.	Carbachol	159-168	protein kinase C alpha	Homo sapiens	28-37
11460267-7	2001	Additional experiments with PKC alpha- or PKC epsilon-specific compounds indicated that the epsilon isozyme of PKC is primarily involved in MAPK activation by carbachol.	Carbachol	159-168	protein kinase C epsilon	Homo sapiens	42-53
11460267-7	2001	Additional experiments with PKC alpha- or PKC epsilon-specific compounds indicated that the epsilon isozyme of PKC is primarily involved in MAPK activation by carbachol.	Carbachol	159-168	protein kinase C alpha	Homo sapiens	28-31
11454952-4	2001	At 40 mM [BAPTA]pip, 100 microM CCh reversibly suppressed I(Ca(L)) maximally by 42%; half-maximal inhibition (20%) required 1 microM.	Carbachol	32-35	prolactin-inducible protein homolog	Cavia porcellus	16-19
11454952-7	2001	Inhibition by 100 microM CCh averaged -1.8 +/- 0.6, -2.3 +/- 0.4, and -4.1 +/- 0.4 pA/pF at 20, 30, and 40 mM [BAPTA](pip), respectively.	Carbachol	25-28	prolactin-inducible protein homolog	Cavia porcellus	118-121
11534853-4	2001	Activation of PLC through Galpha15 in response to carbachol did not increase cytosolic [Ca2+] ([Ca2+]i) but stimulated protein kinase C. While carbachol decreased the secretory activity in non-induced GH3 cells, it increased secretion in cells expressing Galpha15.	Carbachol	50-59	G protein subunit alpha 15	Rattus norvegicus	26-34
11534853-4	2001	Activation of PLC through Galpha15 in response to carbachol did not increase cytosolic [Ca2+] ([Ca2+]i) but stimulated protein kinase C. While carbachol decreased the secretory activity in non-induced GH3 cells, it increased secretion in cells expressing Galpha15.	Carbachol	143-152	G protein subunit alpha 15	Rattus norvegicus	26-34
11534853-4	2001	Activation of PLC through Galpha15 in response to carbachol did not increase cytosolic [Ca2+] ([Ca2+]i) but stimulated protein kinase C. While carbachol decreased the secretory activity in non-induced GH3 cells, it increased secretion in cells expressing Galpha15.	Carbachol	143-152	G protein subunit alpha 15	Rattus norvegicus	255-263
11292831-2	2001	We first show that activation of ERK1/2 by the M(1) mAChR agonist carbachol takes place primarily via a Ras-independent pathway that depends largely upon Rap1, another small GTP-binding protein in the Ras family.	Carbachol	66-75	mitogen activated protein kinase 3	Rattus norvegicus	33-39
11337491-6	2001	Muscarinic stimulation by carbachol reduced the alpha-synuclein oligomer in plasma membrane over a 30-min period, with a concomitant increase of both the oligomer and the monomer in the cytoplasmic fraction.	Carbachol	26-35	synuclein alpha	Homo sapiens	48-63
11337491-8	2001	The carbachol-induced alteration of alpha-synuclein was blocked by atropine.	Carbachol	4-13	synuclein alpha	Homo sapiens	36-51
11337491-9	2001	Translocation of the alpha-synuclein oligomer in response to carbachol stimulation corresponds closely with the time course of ligand-stimulated muscarinic receptor endocytosis.	Carbachol	61-70	synuclein alpha	Homo sapiens	21-36
11401853-5	2001	These data indicate that PI(4,5)P2 synthesis rates and other parameters of CCh-stimulated inositol phospholipid turnover are muscle length-dependent and provide evidence that supports the hypothesis that length-dependent beta1-integrin signals may exert control on CCh-activated PI(4,5)P2 synthesis.	Carbachol	75-78	integrin subunit beta 1	Homo sapiens	221-235
11401853-5	2001	These data indicate that PI(4,5)P2 synthesis rates and other parameters of CCh-stimulated inositol phospholipid turnover are muscle length-dependent and provide evidence that supports the hypothesis that length-dependent beta1-integrin signals may exert control on CCh-activated PI(4,5)P2 synthesis.	Carbachol	265-268	integrin subunit beta 1	Homo sapiens	221-235
11408264-5	2001	Basolateral, but not apical, addition of insulin inhibited carbachol- and thapsigargin-induced chloride secretion in a time- and concentration-dependent fashion.	Carbachol	59-68	insulin	Homo sapiens	41-48
11565612-2	2001	Treatment of differentiated cells with 1 mM carbachol caused rapid increases in the tyrosine phosphorylation of focal adhesion kinase (FAK), Cas, and paxillin.	Carbachol	44-53	protein tyrosine kinase 2	Homo sapiens	112-133
11565612-2	2001	Treatment of differentiated cells with 1 mM carbachol caused rapid increases in the tyrosine phosphorylation of focal adhesion kinase (FAK), Cas, and paxillin.	Carbachol	44-53	protein tyrosine kinase 2	Homo sapiens	135-138
11565612-3	2001	The src family kinase-selective inhibitor PP1 reduced carbachol-stimulated tyrosine phosphorylation of FAK, Cas, and paxillin by 50 to 75%.	Carbachol	54-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
11565612-3	2001	The src family kinase-selective inhibitor PP1 reduced carbachol-stimulated tyrosine phosphorylation of FAK, Cas, and paxillin by 50 to 75%.	Carbachol	54-63	neuropeptide Y receptor Y4	Homo sapiens	42-45
11565612-3	2001	The src family kinase-selective inhibitor PP1 reduced carbachol-stimulated tyrosine phosphorylation of FAK, Cas, and paxillin by 50 to 75%.	Carbachol	54-63	protein tyrosine kinase 2	Homo sapiens	103-106
11565612-4	2001	In contrast, carbachol-stimulated activation of ERK1/2 was unaffected by PP1.	Carbachol	13-22	mitogen-activated protein kinase 3	Homo sapiens	48-54
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Carbachol	32-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Carbachol	32-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Carbachol	32-41	catenin delta 1	Homo sapiens	145-149
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Carbachol	80-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Carbachol	80-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Carbachol	80-89	catenin delta 1	Homo sapiens	145-149
11565612-6	2001	Site-specific FAK phosphotyrosine antibodies were used to determine that the carbachol-stimulated increase in the autophosphorylation of FAK was unaffected by pretreatment with PP1, whereas the carbachol-stimulated increase in the src family kinase-mediated phosphotyrosine of FAK was completely blocked by pretreatment with PP1.	Carbachol	77-86	protein tyrosine kinase 2	Homo sapiens	14-17
11565612-6	2001	Site-specific FAK phosphotyrosine antibodies were used to determine that the carbachol-stimulated increase in the autophosphorylation of FAK was unaffected by pretreatment with PP1, whereas the carbachol-stimulated increase in the src family kinase-mediated phosphotyrosine of FAK was completely blocked by pretreatment with PP1.	Carbachol	77-86	protein tyrosine kinase 2	Homo sapiens	137-140
11565612-6	2001	Site-specific FAK phosphotyrosine antibodies were used to determine that the carbachol-stimulated increase in the autophosphorylation of FAK was unaffected by pretreatment with PP1, whereas the carbachol-stimulated increase in the src family kinase-mediated phosphotyrosine of FAK was completely blocked by pretreatment with PP1.	Carbachol	77-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	231-234
11565612-6	2001	Site-specific FAK phosphotyrosine antibodies were used to determine that the carbachol-stimulated increase in the autophosphorylation of FAK was unaffected by pretreatment with PP1, whereas the carbachol-stimulated increase in the src family kinase-mediated phosphotyrosine of FAK was completely blocked by pretreatment with PP1.	Carbachol	77-86	protein tyrosine kinase 2	Homo sapiens	137-140
11565612-6	2001	Site-specific FAK phosphotyrosine antibodies were used to determine that the carbachol-stimulated increase in the autophosphorylation of FAK was unaffected by pretreatment with PP1, whereas the carbachol-stimulated increase in the src family kinase-mediated phosphotyrosine of FAK was completely blocked by pretreatment with PP1.	Carbachol	77-86	neuropeptide Y receptor Y4	Homo sapiens	325-328
11423385-4	2001	On the other hand, when carbachol and AVP were associated, a significant decrease of AVP hydrosmotic activity occurred (23%).	Carbachol	24-33	arginine vasopressin	Homo sapiens	85-88
11522294-2	2001	We report that apoE4, but not apoE3, disrupts carbachol-stimulated phosphoinositide (PI) hydrolysis in SH-SY5Y neuroblastoma cells.	Carbachol	46-55	apolipoprotein E	Homo sapiens	15-20
11522294-3	2001	Carbachol responses were also disrupted by beta-amyloid (Abeta) (1-42) and apoE4/Abeta(1-42) complexes, but not by apoE3/Abeta(1-42).	Carbachol	0-9	apolipoprotein E	Homo sapiens	75-91
11409731-2	2001	In this study, we report on the ability of carbachol to stimulate the phosphorylation of Akt/PKB, an important target of phosphatidylinositol 3 kinase (PI3 kinase) in 1321N1 human astrocytoma cells.	Carbachol	43-52	AKT serine/threonine kinase 1	Homo sapiens	89-96
11409731-3	2001	Carbachol induced a dose-dependent phosphorylation of Ser473 on Akt, peaking after 15 min.	Carbachol	0-9	AKT serine/threonine kinase 1	Homo sapiens	64-67
11375256-10	2001	In another set of rabbits, the same treatment with EPO also decreased vasodilating responses to carbachol, bradykinin and substance P besides ACh as compared with control group.	Carbachol	96-105	erythropoietin	Oryctolagus cuniculus	51-54
11375962-4	2001	RESULTS: Both cell-permeant serine protease inhibitors blocked amylase secretion in response to secretagogues that use calcium as a second messenger (e.g., cerulein, carbamylcholine, and bombesin) but not to those that use adenosine 3",5"-cyclic monophosphate (cAMP) as a second messenger (e.g., secretin and vasoactive intestinal polypeptide).	Carbachol	166-181	coagulation factor II, thrombin	Homo sapiens	28-43
11358895-0	2001	Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C. BACKGROUND: Interleukin 1beta (IL-1beta) is a potent inhibitor of gastric acid secretion.	Carbachol	14-23	interleukin-1 beta	Oryctolagus cuniculus	53-70
11358895-0	2001	Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C. BACKGROUND: Interleukin 1beta (IL-1beta) is a potent inhibitor of gastric acid secretion.	Carbachol	14-23	interleukin-1 beta	Oryctolagus cuniculus	135-152
11358895-0	2001	Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C. BACKGROUND: Interleukin 1beta (IL-1beta) is a potent inhibitor of gastric acid secretion.	Carbachol	14-23	interleukin-1 beta	Oryctolagus cuniculus	154-162
11358895-6	2001	RESULTS: IL-1beta inhibited carbachol and A23187 stimulated acid secretion in a dose dependent manner.	Carbachol	28-37	interleukin-1 beta	Oryctolagus cuniculus	9-17
11358895-12	2001	CONCLUSIONS: IL-1beta directly inhibits parietal cell carbachol stimulated acid secretion.	Carbachol	54-63	interleukin-1 beta	Oryctolagus cuniculus	13-21
11292831-6	2001	Using specific antibodies, we show that a recently identified Rap1 GEF, calcium- and diacylglycerol-regulated guanine nucleotide exchange factor I (CalDAG-GEFI), is expressed in PC12D cells and that carbachol stimulates the formation of a complex containing CalDAG-GEFI, Rap1, and activated B-Raf.	Carbachol	199-208	Rap guanine nucleotide exchange factor 5	Rattus norvegicus	67-70
11292831-6	2001	Using specific antibodies, we show that a recently identified Rap1 GEF, calcium- and diacylglycerol-regulated guanine nucleotide exchange factor I (CalDAG-GEFI), is expressed in PC12D cells and that carbachol stimulates the formation of a complex containing CalDAG-GEFI, Rap1, and activated B-Raf.	Carbachol	199-208	RAS guanyl releasing protein 2	Rattus norvegicus	72-146
11292831-6	2001	Using specific antibodies, we show that a recently identified Rap1 GEF, calcium- and diacylglycerol-regulated guanine nucleotide exchange factor I (CalDAG-GEFI), is expressed in PC12D cells and that carbachol stimulates the formation of a complex containing CalDAG-GEFI, Rap1, and activated B-Raf.	Carbachol	199-208	RAS guanyl releasing protein 2	Rattus norvegicus	148-159
11423385-5	2001	The inhibitory effect of carbachol on the AVP action was almost completely abolished by the cholinergic antagonists atropine, pirenzepine, 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) and the calcium antagonist lanthanum.	Carbachol	25-34	arginine vasopressin	Homo sapiens	42-45
11292831-6	2001	Using specific antibodies, we show that a recently identified Rap1 GEF, calcium- and diacylglycerol-regulated guanine nucleotide exchange factor I (CalDAG-GEFI), is expressed in PC12D cells and that carbachol stimulates the formation of a complex containing CalDAG-GEFI, Rap1, and activated B-Raf.	Carbachol	199-208	RAS guanyl releasing protein 2	Rattus norvegicus	258-269
11292831-6	2001	Using specific antibodies, we show that a recently identified Rap1 GEF, calcium- and diacylglycerol-regulated guanine nucleotide exchange factor I (CalDAG-GEFI), is expressed in PC12D cells and that carbachol stimulates the formation of a complex containing CalDAG-GEFI, Rap1, and activated B-Raf.	Carbachol	199-208	B-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	291-296
11292831-7	2001	Finally, we show that expression of CalDAG-GEFI antisense RNA largely blocks carbachol-stimulated activation of hemagglutinin (HA)1-tagged B-Raf and formation of the CalDAG-GEFI/Rap1/HA1-tagged B-Raf complex.	Carbachol	77-86	RAS guanyl releasing protein 2	Rattus norvegicus	36-47
11292831-7	2001	Finally, we show that expression of CalDAG-GEFI antisense RNA largely blocks carbachol-stimulated activation of hemagglutinin (HA)1-tagged B-Raf and formation of the CalDAG-GEFI/Rap1/HA1-tagged B-Raf complex.	Carbachol	77-86	B-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	139-144
11292831-7	2001	Finally, we show that expression of CalDAG-GEFI antisense RNA largely blocks carbachol-stimulated activation of hemagglutinin (HA)1-tagged B-Raf and formation of the CalDAG-GEFI/Rap1/HA1-tagged B-Raf complex.	Carbachol	77-86	RAS guanyl releasing protein 2	Rattus norvegicus	166-177
11292831-7	2001	Finally, we show that expression of CalDAG-GEFI antisense RNA largely blocks carbachol-stimulated activation of hemagglutinin (HA)1-tagged B-Raf and formation of the CalDAG-GEFI/Rap1/HA1-tagged B-Raf complex.	Carbachol	77-86	B-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	194-199
11259416-4	2001	In HEK293 cells stably transfected with human TRPC3 channels, the actions of 2-APB to block carbachol-induced InsP(3)R-mediated store release and carbachol-induced Sr(2+) entry through TRPC3 channels were both reversed at high agonist levels, suggesting InsP(3)Rs mediate TRPC3 activation.	Carbachol	92-101	transient receptor potential cation channel subfamily C member 3	Homo sapiens	46-51
11389190-9	2001	Functional consequences of these events are a reduction in carbachol-stimulated p42/44(MAPK) and CREB phosphorylation, as well as induction of c-fos.	Carbachol	59-68	cyclin dependent kinase 20	Homo sapiens	80-83
11389190-9	2001	Functional consequences of these events are a reduction in carbachol-stimulated p42/44(MAPK) and CREB phosphorylation, as well as induction of c-fos.	Carbachol	59-68	cAMP responsive element binding protein 1	Homo sapiens	97-101
11423971-5	2001	Although Gem expression is rare in epithelial and hematopoietic cancer cell lines, constitutive Gem levels were detected in several neuroblastoma cell lines and could be further induced as much as 10-fold following treatment with PMA or the acetylcholine muscarinic agonist, carbachol.	Carbachol	275-284	GTP binding protein (gene overexpressed in skeletal muscle)	Mus musculus	96-99
11292627-5	2001	As demonstrated previously for acute CO2-regulated cotransport activity, we found that inhibitors of Src family kinases (SFKs) or the classic mitogen-activated protein kinase (MAPK) pathway prevented the stimulation of NBC activity by carbachol.	Carbachol	235-244	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	101-104
11292627-5	2001	As demonstrated previously for acute CO2-regulated cotransport activity, we found that inhibitors of Src family kinases (SFKs) or the classic mitogen-activated protein kinase (MAPK) pathway prevented the stimulation of NBC activity by carbachol.	Carbachol	235-244	mitogen-activated protein kinase 3	Homo sapiens	176-180
11292627-6	2001	The ability of carbachol to activate Src, as well as the proximal (Raf) and distal [extracellular signal-regulated kinases 1 and 2 (ERK1/2)] elements of the classic MAPK module, was compatible with these findings.	Carbachol	15-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-40
11292627-6	2001	The ability of carbachol to activate Src, as well as the proximal (Raf) and distal [extracellular signal-regulated kinases 1 and 2 (ERK1/2)] elements of the classic MAPK module, was compatible with these findings.	Carbachol	15-24	mitogen-activated protein kinase 3	Homo sapiens	165-169
11323367-4	2001	Carbachol (0.5-4.0 microg) administered into the mPRF produced significant dose- and time-dependent antinociception, sedation, and motor dysfunction.	Carbachol	0-9	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	49-53
11323367-7	2001	These results suggest that the antinociceptive action of carbachol is mediated by muscarinic cholinergic receptor activation, especially by M(2) receptor subtype in mPRF and spinal cord, and that although oxycodone seems unlikely to affect the cholinergic transmission of mPRF, spinal oxycodone-induced analgesia is at least partly mediated via the activation of M(2) receptor subtype at the spinal cord.	Carbachol	57-66	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	165-169
11292391-14	2001	The anti-adrenergic effect of ADO on I(NaCa) was mimicked by externally applied carbachol (CCh, 10 microM), a muscarinic receptor agonist.	Carbachol	80-89	nascent polypeptide-associated complex subunit alpha	Cavia porcellus	39-43
11292391-14	2001	The anti-adrenergic effect of ADO on I(NaCa) was mimicked by externally applied carbachol (CCh, 10 microM), a muscarinic receptor agonist.	Carbachol	91-94	nascent polypeptide-associated complex subunit alpha	Cavia porcellus	39-43
11316737-1	2001	Inositol 1,4,5-trisphosphate receptor (IP3R) protein levels in isolated rat pancreatic islets were investigated in response to carbachol (CCh) and sulfated cholecystokinin 26-33 amide stimulation.	Carbachol	127-136	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	39-43
11316737-1	2001	Inositol 1,4,5-trisphosphate receptor (IP3R) protein levels in isolated rat pancreatic islets were investigated in response to carbachol (CCh) and sulfated cholecystokinin 26-33 amide stimulation.	Carbachol	138-141	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	39-43
11316737-2	2001	Within 2 h, CCh reduced IP3R-I protein levels by 22% and IP3R-II and -III levels to 65% or more below basal.	Carbachol	12-15	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	24-28
11316737-2	2001	Within 2 h, CCh reduced IP3R-I protein levels by 22% and IP3R-II and -III levels to 65% or more below basal.	Carbachol	12-15	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	57-61
11316737-4	2001	The effect of CCh was concentration- and time-dependent, with a persistent decline in IP3R levels for up to 6 h after the onset of stimulation.	Carbachol	14-17	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	86-90
11316737-6	2001	Proteasome inhibition completely blocked the down-regulatory effects of CCh on IP3Rs and significantly increased the insulin secretory response to glucose stimulation in the presence of CCH: Islet stimulation by glucose, alpha-ketoisocaproic acid, and tolbutamide completely protected IP3Rs against the down-regulatory effects of CCH: 2-deoxyglucose and 3-O-methyl glucose failed to affect CCh-induced IP3R down-regulation.	Carbachol	72-75	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	79-83
11311050-5	2001	We found that: (a) PGF(2alpha)and CCh increased p38 MAP kinase activity by 197 and 215%, respectively, and increased p42/p44 MAP kinase activity by 200 and 125%, respectively.	Carbachol	34-37	mitogen-activated protein kinase 14	Homo sapiens	48-51
11311050-5	2001	We found that: (a) PGF(2alpha)and CCh increased p38 MAP kinase activity by 197 and 215%, respectively, and increased p42/p44 MAP kinase activity by 200 and 125%, respectively.	Carbachol	34-37	cyclin dependent kinase 20	Homo sapiens	117-120
11311050-5	2001	We found that: (a) PGF(2alpha)and CCh increased p38 MAP kinase activity by 197 and 215%, respectively, and increased p42/p44 MAP kinase activity by 200 and 125%, respectively.	Carbachol	34-37	interferon induced protein 44	Homo sapiens	121-124
11311050-6	2001	(b) SB202190, a p38 MAP kinase specific inhibitor, inhibited PGF(2alpha)- and CCh-induced cPLA(2)phosphorylation by 92 and 85%, respectively, and AA release by 62 and 78%, respectively.	Carbachol	78-81	mitogen-activated protein kinase 14	Homo sapiens	16-19
11311050-7	2001	(c) PD98059, a p42/p44 MAP kinase inhibitor, inhibited CCh-induced cPLA(2)phosphorylation by 70% and AA release by 71%, but had no effect on that of PGF(2alpha).	Carbachol	55-58	cyclin dependent kinase 20	Homo sapiens	15-18
11311050-7	2001	(c) PD98059, a p42/p44 MAP kinase inhibitor, inhibited CCh-induced cPLA(2)phosphorylation by 70% and AA release by 71%, but had no effect on that of PGF(2alpha).	Carbachol	55-58	interferon induced protein 44	Homo sapiens	19-22
11311050-8	2001	(d) Inhibition of PKC activity by RO 31-8220 inhibited both PGF(2alpha)- and CCh-stimulation of p38 MAP kinase, p42/p44 MAP kinases and cPLA(2)phosphorylation.	Carbachol	77-80	mitogen-activated protein kinase 14	Homo sapiens	96-99
11311050-8	2001	(d) Inhibition of PKC activity by RO 31-8220 inhibited both PGF(2alpha)- and CCh-stimulation of p38 MAP kinase, p42/p44 MAP kinases and cPLA(2)phosphorylation.	Carbachol	77-80	cyclin dependent kinase 20	Homo sapiens	112-115
11311050-8	2001	(d) Inhibition of PKC activity by RO 31-8220 inhibited both PGF(2alpha)- and CCh-stimulation of p38 MAP kinase, p42/p44 MAP kinases and cPLA(2)phosphorylation.	Carbachol	77-80	interferon induced protein 44	Homo sapiens	116-119
11259416-4	2001	In HEK293 cells stably transfected with human TRPC3 channels, the actions of 2-APB to block carbachol-induced InsP(3)R-mediated store release and carbachol-induced Sr(2+) entry through TRPC3 channels were both reversed at high agonist levels, suggesting InsP(3)Rs mediate TRPC3 activation.	Carbachol	92-101	transient receptor potential cation channel subfamily C member 3	Homo sapiens	185-190
11259416-4	2001	In HEK293 cells stably transfected with human TRPC3 channels, the actions of 2-APB to block carbachol-induced InsP(3)R-mediated store release and carbachol-induced Sr(2+) entry through TRPC3 channels were both reversed at high agonist levels, suggesting InsP(3)Rs mediate TRPC3 activation.	Carbachol	92-101	transient receptor potential cation channel subfamily C member 3	Homo sapiens	185-190
11287327-3	2001	Acute exposure to angiostatin or endostatin nearly abolished subsequent endothelial [Ca(2+)](i) responses to carbachol or to thapsigargin; conversely, thapsigargin attenuated the Ca(2+) signal elicited by endostatin.	Carbachol	109-118	plasminogen	Mus musculus	18-29
11287327-3	2001	Acute exposure to angiostatin or endostatin nearly abolished subsequent endothelial [Ca(2+)](i) responses to carbachol or to thapsigargin; conversely, thapsigargin attenuated the Ca(2+) signal elicited by endostatin.	Carbachol	109-118	collagen, type XVIII, alpha 1	Mus musculus	33-43
11303068-4	2001	Thapsigargin, xestospongin C, and carbachol/Ca(2+)-free buffer blocked significantly the PCB-induced Ca(2+) transient, whereas both ryanodine (to deplete ryanodine-sensitive stores) and the L-type Ca(2+) channel blocker nifedipine were without effect on the A1254 initial Ca(2+) transient.	Carbachol	34-43	pyruvate carboxylase	Rattus norvegicus	89-92
11306714-6	2001	Scabronine G-ME concentration-dependently inhibited the carbachol-induced inositol phosphate accumulation in 1321N1 cells, which was reversed by GF109203X, an inhibitor of protein kinase C (PKC) isoforms.	Carbachol	56-65	protein kinase C zeta	Homo sapiens	190-193
11322774-4	2001	RGS2 mRNA levels were increased in differentiated cells by heat shock, carbachol, and activation of protein kinase C. After transient transfection of GFP-tagged RGS2, a predominant nuclear localization was observed by confocal microscopy.	Carbachol	71-80	regulator of G protein signaling 2	Homo sapiens	0-4
11322774-4	2001	RGS2 mRNA levels were increased in differentiated cells by heat shock, carbachol, and activation of protein kinase C. After transient transfection of GFP-tagged RGS2, a predominant nuclear localization was observed by confocal microscopy.	Carbachol	71-80	regulator of G protein signaling 2	Homo sapiens	161-165
11379045-7	2001	In addition, both IFN gamma and carbachol increase prostaglandin E2 production in SMG, but while indomethacin potentiates IFN gamma effect on amylase secretion, it blunted amylase secretion exerted by carbachol.	Carbachol	201-210	interferon gamma	Mus musculus	18-27
11379045-8	2001	Thus, IFN gamma and carbachol stimulate IFN gamma secretion on SMG in a dose-dependent manner.	Carbachol	20-29	interferon gamma	Mus musculus	40-49
11259416-4	2001	In HEK293 cells stably transfected with human TRPC3 channels, the actions of 2-APB to block carbachol-induced InsP(3)R-mediated store release and carbachol-induced Sr(2+) entry through TRPC3 channels were both reversed at high agonist levels, suggesting InsP(3)Rs mediate TRPC3 activation.	Carbachol	146-155	transient receptor potential cation channel subfamily C member 3	Homo sapiens	46-51
11352632-0	2001	Carbachol stimulates TYR phosphorylation and association of PKCdelta and PYK2 in pancreas.	Carbachol	0-9	protein tyrosine kinase 2 beta	Rattus norvegicus	73-77
11259416-4	2001	In HEK293 cells stably transfected with human TRPC3 channels, the actions of 2-APB to block carbachol-induced InsP(3)R-mediated store release and carbachol-induced Sr(2+) entry through TRPC3 channels were both reversed at high agonist levels, suggesting InsP(3)Rs mediate TRPC3 activation.	Carbachol	146-155	transient receptor potential cation channel subfamily C member 3	Homo sapiens	185-190
11352632-2	2001	The Ca2+-dependent tyrosine kinase PYK2 coimmunoprecipitated with PKCdelta from carbachol-exposed cells and also exhibited increased tyrosine phosphorylation.	Carbachol	80-89	protein tyrosine kinase 2 beta	Rattus norvegicus	35-39
11352632-3	2001	Tyrosine phosphorylation of both PKCdelta and PYK2 was concentration-dependent with respect to carbachol, and rapid, reaching maximal levels by 5 min of treatment.	Carbachol	95-104	protein tyrosine kinase 2 beta	Rattus norvegicus	46-50
11259416-4	2001	In HEK293 cells stably transfected with human TRPC3 channels, the actions of 2-APB to block carbachol-induced InsP(3)R-mediated store release and carbachol-induced Sr(2+) entry through TRPC3 channels were both reversed at high agonist levels, suggesting InsP(3)Rs mediate TRPC3 activation.	Carbachol	146-155	transient receptor potential cation channel subfamily C member 3	Homo sapiens	185-190
11245606-4	2001	Carbachol enhances photoaffinity labeling ([alpha-(32)P]GTP-azidoaniline) of only 42-kDa proteins that are subsequently tractable to immunoprecipitation by antibodies specific for Galpha(q) or Galpha(11) but not Galpha(12) or Galpha(13).	Carbachol	0-9	G protein subunit alpha q	Rattus norvegicus	180-203
11245606-4	2001	Carbachol enhances photoaffinity labeling ([alpha-(32)P]GTP-azidoaniline) of only 42-kDa proteins that are subsequently tractable to immunoprecipitation by antibodies specific for Galpha(q) or Galpha(11) but not Galpha(12) or Galpha(13).	Carbachol	0-9	G protein subunit alpha 12	Rattus norvegicus	212-222
11245606-4	2001	Carbachol enhances photoaffinity labeling ([alpha-(32)P]GTP-azidoaniline) of only 42-kDa proteins that are subsequently tractable to immunoprecipitation by antibodies specific for Galpha(q) or Galpha(11) but not Galpha(12) or Galpha(13).	Carbachol	0-9	G protein subunit alpha 13	Rattus norvegicus	226-236
11347653-4	2001	By contrast, the CCh-stimulated initial [Ca2+]i increase was reduced at 0.5 and 4 h post-irradiation in all cell types and remained decreased at 24 h in wild-type and control-transfected cells, but recovered in Bcl-2- and Bcl-XL-transfectants.	Carbachol	17-20	BCL2 apoptosis regulator	Homo sapiens	211-216
11347653-4	2001	By contrast, the CCh-stimulated initial [Ca2+]i increase was reduced at 0.5 and 4 h post-irradiation in all cell types and remained decreased at 24 h in wild-type and control-transfected cells, but recovered in Bcl-2- and Bcl-XL-transfectants.	Carbachol	17-20	BCL2 like 1	Homo sapiens	222-228
11347653-5	2001	The formation of inositol 1,4,5-trisphosphate (IP3) in response to CCh at 4-h post-irradiation was decreased in wild-type and control-transfected cells, but not in Bcl-2 and Bcl-XL transfectants.	Carbachol	67-70	BCL2 like 1	Homo sapiens	174-180
11383923-2	2001	In pancreases from fed rats, leptin failed to alter the insulin secretion elicited by glucose, arginine or tolbutamide, but inhibited the insulin response to both CCK-8 and carbachol, secretagogues known to act on the B-cell by increasing phospholipid turnover.	Carbachol	173-182	leptin	Rattus norvegicus	29-35
11353015-18	2001	In conclusion, st. radiatum interneurons of CA3 hippocampal region represent a class of nonpyramidal cells with action potentials followed by an AHP of relatively short duration, partially generated by apamin and carbachol-sensitive conductances involved in the regulation of the cell firing rate.	Carbachol	213-222	carbonic anhydrase 3	Rattus norvegicus	44-47
11383923-7	2001	Leptin inhibition of carbachol-induced insulin output might reflect a restraining effect of this peptide on the cholinergic stimulation of insulin release.	Carbachol	21-30	leptin	Rattus norvegicus	0-6
11259766-0	2001	Intracerebroventricular carbachol induces FOS immunoreactivity in lamina terminalis neurons projecting to the supraoptic nucleus.	Carbachol	24-33	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-45
11679020-10	2001	Further evidence for muscarininc receptor antagonism by tacrine was a small rightward shift of the concentration-response curve for carbachol, an agonist immune to cholinesterase.	Carbachol	132-141	butyrylcholinesterase	Rattus norvegicus	164-178
11305656-3	2001	The nicotinic acetylcholine receptor (nAChr) agonists acetylcholine, carbachol, and (-)-nicotine were fractionated and detected by patch-clamped pheochromcytoma detector cells.	Carbachol	69-78	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	38-43
11181542-2	2001	In dog thyroid primary cultures, the use of the phosphodiesterase-resistant analog of cAMP (Bu)(2)cAMP instead of TSH allowed to unveil a potent comitogenic activity of carbamylcholine, which can substitute for insulin and was shown to mimic insulin action on cell cycle regulatory proteins.	Carbachol	169-184	insulin	Canis lupus familiaris	211-218
11181542-2	2001	In dog thyroid primary cultures, the use of the phosphodiesterase-resistant analog of cAMP (Bu)(2)cAMP instead of TSH allowed to unveil a potent comitogenic activity of carbamylcholine, which can substitute for insulin and was shown to mimic insulin action on cell cycle regulatory proteins.	Carbachol	169-184	insulin	Canis lupus familiaris	242-249
11181542-3	2001	Like insulin, carbamylcholine induced the accumulation of cyclin D3 and overcame the repression by cAMP of this protein, which was shown 1) to be essential for cell cycle progression by means of microinjections of a neutralizing antibody; and 2) to be rate limiting for the cAMP-dependent assembly of cyclin D3-cdk4 complexes, their nuclear translocation and the phosphorylation of pRb.	Carbachol	14-29	insulin	Canis lupus familiaris	5-12
11181542-3	2001	Like insulin, carbamylcholine induced the accumulation of cyclin D3 and overcame the repression by cAMP of this protein, which was shown 1) to be essential for cell cycle progression by means of microinjections of a neutralizing antibody; and 2) to be rate limiting for the cAMP-dependent assembly of cyclin D3-cdk4 complexes, their nuclear translocation and the phosphorylation of pRb.	Carbachol	14-29	cyclin D3	Canis lupus familiaris	58-67
11181542-3	2001	Like insulin, carbamylcholine induced the accumulation of cyclin D3 and overcame the repression by cAMP of this protein, which was shown 1) to be essential for cell cycle progression by means of microinjections of a neutralizing antibody; and 2) to be rate limiting for the cAMP-dependent assembly of cyclin D3-cdk4 complexes, their nuclear translocation and the phosphorylation of pRb.	Carbachol	14-29	cyclin D3	Canis lupus familiaris	301-315
11245595-0	2001	PLD pathway involved in carbachol-induced Cl- secretion: possible role of TNF-alpha.	Carbachol	24-33	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
11245595-0	2001	PLD pathway involved in carbachol-induced Cl- secretion: possible role of TNF-alpha.	Carbachol	24-33	tumor necrosis factor	Homo sapiens	74-83
11245595-1	2001	In a previous study, it was found that exposure to tumor necrosis factor-alpha (TNF-alpha) potentiated the electrophysiological response to carbachol in a time-dependent and cycloheximide-sensitive manner.	Carbachol	140-149	tumor necrosis factor	Homo sapiens	51-78
11245595-1	2001	In a previous study, it was found that exposure to tumor necrosis factor-alpha (TNF-alpha) potentiated the electrophysiological response to carbachol in a time-dependent and cycloheximide-sensitive manner.	Carbachol	140-149	tumor necrosis factor	Homo sapiens	80-89
11245595-5	2001	The aim of the present study was to investigate whether the phospholipase D (PLD) pathway plays a role in the carbachol response and the potentiating effect of TNF-alpha.	Carbachol	110-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	60-75
11245595-5	2001	The aim of the present study was to investigate whether the phospholipase D (PLD) pathway plays a role in the carbachol response and the potentiating effect of TNF-alpha.	Carbachol	110-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	77-80
11259487-2	2001	However, when DPDPE was applied during concomitant Gq-coupled m3 muscarinic receptor stimulation by carbachol or oxotremorine-M, it produced an elevation of [Ca(2+)](i).	Carbachol	100-109	cholinergic receptor muscarinic 3	Homo sapiens	62-84
11166329-6	2001	When challenged with carbachol, IRK1 currents recorded from cells co-transfected with Galpha(q) were potently inhibited compared with controls.	Carbachol	21-30	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	32-36
11222647-4	2001	We demonstrate that stimulation of these mAChRs with carbachol, a muscarinic agonist, activated extracellular-regulated kinases (Erk1/2) and phosphatidylinositol-3 kinase (PI-3K).	Carbachol	53-62	mitogen activated protein kinase 3	Rattus norvegicus	129-135
11166329-6	2001	When challenged with carbachol, IRK1 currents recorded from cells co-transfected with Galpha(q) were potently inhibited compared with controls.	Carbachol	21-30	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	86-92
11166329-8	2001	Concentration response curves revealed that carbachol was 16 times more potent at inhibiting IRK1 currents in cells co-transfected with Galpha(q) as compared with Galpha(12) co-transfected cells.	Carbachol	44-53	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	93-97
11166329-8	2001	Concentration response curves revealed that carbachol was 16 times more potent at inhibiting IRK1 currents in cells co-transfected with Galpha(q) as compared with Galpha(12) co-transfected cells.	Carbachol	44-53	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	136-142
11172778-0	2001	GABAergic neurons of the laterodorsal and pedunculopontine tegmental nuclei of the cat express c-fos during carbachol-induced active sleep.	Carbachol	108-117	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	95-100
11287096-7	2001	Leptin and carbachol also caused an increased intracellular content of NPY.	Carbachol	11-20	neuropeptide Y	Homo sapiens	71-74
11172778-3	2001	Consequently, we sought to determine if these neurons are activated (as indicated by their c-fos expression) during active sleep induced by the microinjection of carbachol into the rostro-dorsal pons (AS-carbachol).	Carbachol	162-171	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	91-96
11172737-5	2001	Culture of islets or betaTC3 cells with carbachol (0.5 mM) reduced IP3R-I mRNA expression levels below control.	Carbachol	40-49	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	67-71
11256182-1	2001	Since the early "60s, injections of a broad-spectrum muscarinic cholinergic agonist, carbachol, into the medial pontine reticular formation (mPRF) of cats have been extensively used as a tool with which to study the neural mechanisms of rapid eye movement (REM) sleep.	Carbachol	85-94	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	141-145
11256182-9	2001	While carbachol and many other neurotransmitters and peptides microinjected into the mPRF evoke, enhance or suppress REM sleep, the most sensitive site(s) of their actions have not been fully mapped, and the nature of the cellular and neurochemical interactions taking place at the sites where carbachol triggers the REM sleep-like state remain largely unknown.	Carbachol	6-15	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	85-89
11256182-10	2001	Similarly, little is known about the pathways between the mPRF and medial medullary reticular formation, but the existing evidence suggests that they are reciprocal and essential for the generation of both natural and carbachol-induced REM sleep.	Carbachol	218-227	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	58-62
11172737-7	2001	Culture of islets for up to 6 hr with carbachol reduced IP3R-I and -III protein expression in a time-dependent manner with a half-maximal effect on type I at 1 hr.	Carbachol	38-47	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	56-60
11172737-9	2001	The carbachol-induced decrease in IP3R-I and -III protein expression was reversed by carbobenzoxyl-leucinyl-leucinyl-leucinyl-H (MG-132), a proteasome inhibitor.	Carbachol	4-13	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	34-38
11172737-10	2001	Thus, glucose failed to regulate mouse islet IP3R mRNA expression, whereas carbachol stimulation down-regulated IP3R mRNA and protein.	Carbachol	75-84	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	112-116
11165010-4	2001	This is likely due to the effect of carbachol, observed after 24 h, to increase the levels of steroid acute regulatory (StAR) protein, as found in Western blots.	Carbachol	36-45	steroidogenic acute regulatory protein	Homo sapiens	120-124
11181421-12	2001	Carbachol and Tg produced further increases in calcium/GTP-induced tone and, in both cases, this additional tone was relaxed by NO and 8-Br-cyclic GMP.	Carbachol	0-9	5'-nucleotidase, cytosolic II	Mus musculus	147-150
11769308-3	2001	In a network model of area CA3, the time scale for CCH-delta corresponded to the decay constant of the gating variable of the calcium-dependent potassium (K-AHP) current, that of CCH-theta to an intrinsic subthreshold membrane potential oscillation of the pyramidal cells, and that of CCH-gamma to the decay constant of GABAergic inhibitory synaptic potentials onto the pyramidal cells.	Carbachol	51-54	carbonic anhydrase 3	Rattus norvegicus	27-30
11159694-5	2001	A concentration-dependent increase in cyclic GMP production was observed in HEL299 cells incubated with carbachol, cocaine, or MEG for 24 h. The increase in cyclic GMP content was 3.6 fold for 1 microM carbachol (P &lt; 0.01), 3.1 fold for 1 microM cocaine (P &lt; 0.01), and 7.8 fold for 1 microM MEG (P &lt; 0.001), respectively.	Carbachol	104-113	5'-nucleotidase, cytosolic II	Homo sapiens	45-48
11159694-5	2001	A concentration-dependent increase in cyclic GMP production was observed in HEL299 cells incubated with carbachol, cocaine, or MEG for 24 h. The increase in cyclic GMP content was 3.6 fold for 1 microM carbachol (P &lt; 0.01), 3.1 fold for 1 microM cocaine (P &lt; 0.01), and 7.8 fold for 1 microM MEG (P &lt; 0.001), respectively.	Carbachol	104-113	5'-nucleotidase, cytosolic II	Homo sapiens	164-167
11159694-5	2001	A concentration-dependent increase in cyclic GMP production was observed in HEL299 cells incubated with carbachol, cocaine, or MEG for 24 h. The increase in cyclic GMP content was 3.6 fold for 1 microM carbachol (P &lt; 0.01), 3.1 fold for 1 microM cocaine (P &lt; 0.01), and 7.8 fold for 1 microM MEG (P &lt; 0.001), respectively.	Carbachol	202-211	5'-nucleotidase, cytosolic II	Homo sapiens	45-48
11159694-5	2001	A concentration-dependent increase in cyclic GMP production was observed in HEL299 cells incubated with carbachol, cocaine, or MEG for 24 h. The increase in cyclic GMP content was 3.6 fold for 1 microM carbachol (P &lt; 0.01), 3.1 fold for 1 microM cocaine (P &lt; 0.01), and 7.8 fold for 1 microM MEG (P &lt; 0.001), respectively.	Carbachol	202-211	5'-nucleotidase, cytosolic II	Homo sapiens	164-167
11159694-17	2001	However, the inducible isoform of nitric oxide synthase (iNOS) was induced in the presence of cocaine or carbachol and this induction was significantly attenuated after addition of atropine or methoctramine.	Carbachol	105-114	nitric oxide synthase 2	Homo sapiens	57-61
11769308-3	2001	In a network model of area CA3, the time scale for CCH-delta corresponded to the decay constant of the gating variable of the calcium-dependent potassium (K-AHP) current, that of CCH-theta to an intrinsic subthreshold membrane potential oscillation of the pyramidal cells, and that of CCH-gamma to the decay constant of GABAergic inhibitory synaptic potentials onto the pyramidal cells.	Carbachol	179-182	carbonic anhydrase 3	Rattus norvegicus	27-30
11769308-3	2001	In a network model of area CA3, the time scale for CCH-delta corresponded to the decay constant of the gating variable of the calcium-dependent potassium (K-AHP) current, that of CCH-theta to an intrinsic subthreshold membrane potential oscillation of the pyramidal cells, and that of CCH-gamma to the decay constant of GABAergic inhibitory synaptic potentials onto the pyramidal cells.	Carbachol	179-182	carbonic anhydrase 3	Rattus norvegicus	27-30
11301206-6	2001	Such destruction also abolished; (i) intraseptal carbachol-induced suppression of CA1 population spike, and (ii) stimulation-intensity dependent increase in amplitude, but not frequency, of theta evoked on electrical stimulation in the region of oral part of pontine reticular nucleus.	Carbachol	49-58	carbonic anhydrase 1	Rattus norvegicus	82-85
11020447-4	2000	In the present paper, we showed that in 123-1N1 human astrocytoma cells, which express the G-protein-coupled M2, M3, and M5 muscarinic receptors, PKC zeta is activated by carbachol in a concentration-dependent manner, resulting in the translocation of PKC zeta from the cytoplasm to granules in the perinuclear region.	Carbachol	171-180	protein kinase C zeta	Homo sapiens	146-154
10986289-13	2000	In m1 muscarinic receptor transfected HEK-293 cells, carbachol inhibited insulin-like growth factor-1 stimulated phosphorylation at Ser(473) of endogenous Akt in an atropine-reversible fashion.	Carbachol	53-62	insulin like growth factor 1	Homo sapiens	73-101
10986289-13	2000	In m1 muscarinic receptor transfected HEK-293 cells, carbachol inhibited insulin-like growth factor-1 stimulated phosphorylation at Ser(473) of endogenous Akt in an atropine-reversible fashion.	Carbachol	53-62	AKT serine/threonine kinase 1	Homo sapiens	155-158
11073886-6	2000	Carbachol significantly attenuated the isoproterenol response in wild-type and Galpha(i3)-null cells but had no effect in Galpha(i2)-null cells.	Carbachol	0-9	brain protein I3	Mus musculus	79-88
10945986-1	2000	Stimulation of RBL-2H3 m1 mast cells through the IgE receptor with antigen, or through a G protein-coupled receptor with carbachol, leads to the rapid appearance of phosphothreonine in nonmuscle myosin heavy chain II-A (NMHC-IIA).	Carbachol	121-130	myosin heavy chain 9-like 1	Rattus norvegicus	185-218
10945986-1	2000	Stimulation of RBL-2H3 m1 mast cells through the IgE receptor with antigen, or through a G protein-coupled receptor with carbachol, leads to the rapid appearance of phosphothreonine in nonmuscle myosin heavy chain II-A (NMHC-IIA).	Carbachol	121-130	myosin heavy chain 9-like 1	Rattus norvegicus	220-228
11139286-12	2000	Activation of the Fas pathway in the Bcl-2 and Bcl-xL transfectants by antibody also inhibited carbachol and EGF responsiveness (i.e., Ca2+ mobilization and/or influx) by 50-60%.	Carbachol	95-104	BCL2 apoptosis regulator	Homo sapiens	37-42
11139286-12	2000	Activation of the Fas pathway in the Bcl-2 and Bcl-xL transfectants by antibody also inhibited carbachol and EGF responsiveness (i.e., Ca2+ mobilization and/or influx) by 50-60%.	Carbachol	95-104	BCL2 like 1	Homo sapiens	47-53
11069606-0	2000	A model of gamma-frequency network oscillations induced in the rat CA3 region by carbachol in vitro.	Carbachol	81-90	carbonic anhydrase 3	Rattus norvegicus	67-70
11186246-10	2000	These results suggested that amlexanox may not affect either Ca2+ mobilization or calmodulin activity, although it inhibits myosin light-chain kinase, which may inhibit carbachol-induced contraction.	Carbachol	169-178	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	124-149
11090124-11	2000	On normal detrusor in vitro, 4-DAMP and methoctramine caused surmountable antagonism of responses to carbachol with pK(B) values of 9.37+/-0.07 and 6.05+/-0.05 respectively.	Carbachol	101-110	AKT serine/threonine kinase 1	Sus scrofa	116-121
11074189-8	2000	Rats with seizures induced by PAG carbachol microinjections exhibited dense c-fos-like immunoreactivity in the dentate gyrus but not the CA(1) or CA(3) regions, amygdala, piriform cortex, perirhinal cortex or hypothalamus.	Carbachol	34-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-81
11122360-4	2000	When administered alone, PACAP (3 pmol) or carbachol (110 pmol) induced an enhancement of REM sleep during 8 h (+61%, n = 8; +70%, n = 5), which was totally prevented by infusion of atropine (290 pmol) for PACAP, or of PACAP6-27 (3 pmol) for carbachol.	Carbachol	43-52	adenylate cyclase activating polypeptide 1	Rattus norvegicus	206-211
11122360-4	2000	When administered alone, PACAP (3 pmol) or carbachol (110 pmol) induced an enhancement of REM sleep during 8 h (+61%, n = 8; +70%, n = 5), which was totally prevented by infusion of atropine (290 pmol) for PACAP, or of PACAP6-27 (3 pmol) for carbachol.	Carbachol	242-251	adenylate cyclase activating polypeptide 1	Rattus norvegicus	25-30
11233758-5	2000	Carbachol caused an increase in phorbol ester binding and translocation of PKCepsilon, however, these were inhibited only by 100-200 mM ethanol.	Carbachol	0-9	protein kinase C epsilon	Homo sapiens	75-85
11233758-6	2000	On the other hand, translocation of the atypical PKCzeta to the perinuclear area by carbachol was inhibited by ethanol in a dose-dependent manner (10-100 mM).	Carbachol	84-93	protein kinase C zeta	Homo sapiens	49-56
11082488-0	2000	GABAergic neurons of the cat dorsal raphe nucleus express c-fos during carbachol-induced active sleep.	Carbachol	71-80	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	58-63
11069954-8	2000	(6) Twenty Hertz activity after orthodromic activation of field CA3 was distributed in the same manner as carbachol-induced beta waves and was generated by a current source in the apical dendrites of CA3.	Carbachol	106-115	carbonic anhydrase 3	Homo sapiens	64-67
11069954-8	2000	(6) Twenty Hertz activity after orthodromic activation of field CA3 was distributed in the same manner as carbachol-induced beta waves and was generated by a current source in the apical dendrites of CA3.	Carbachol	106-115	carbonic anhydrase 3	Homo sapiens	200-203
11078394-2	2000	Endothelin-1 (ET-1; 0.1-100.0 nM) caused graded tonic contractions with a CK50 (concentration causing response equivalent to 50% of KCl 80 mM) of 3.4 nM and EH (response to highest concentration) of 186 +/- 22, being 40-fold less potent than cholecystokinin-8 (CCK-8), 103-fold more potent than carbachol, but equipotent to ET-3, sarafotoxin S6c (S6c) and IRL 1620.	Carbachol	295-304	endothelin-1	Oryctolagus cuniculus	0-12
11050286-3	2000	We found that treatment of the muscle with 2"-Amino-3"-methoxyflavone (PD98059) (10 microM), a specific inhibitor of MAP kinase kinase (MEK), inhibited significantly prostaglandin F(2alpha)- and latanoprost-induced phosphorylation and contraction, but had little effect on those evoked by carbachol.	Carbachol	289-298	mitogen-activated protein kinase kinase 7	Homo sapiens	136-139
11027250-4	2000	gamma activity induced by either arterial perfusion or intraparenchymal application of CCh showed a phase reversal across mEC layer II and was reduced or abolished in a spatially localized region by focal infusions of atropine, bicuculline, and CNQX.	Carbachol	87-90	chemokine (C-C motif) ligand 28	Mus musculus	122-125
11027250-6	2000	Finally, gamma oscillations recorded at multiple sites across the surface of the mEC using array electrodes during arterial perfusion of CCh demonstrated a decline in synchronization (coherence) as the interelectrode distance increased.	Carbachol	137-140	chemokine (C-C motif) ligand 28	Mus musculus	81-84
11027250-8	2000	These results suggest that CCh-induced gamma oscillations in the mEC are mediated through direct muscarinic excitation of a highly localized reciprocal inhibitory-excitatory network located in superficial layers.	Carbachol	27-30	chemokine (C-C motif) ligand 28	Mus musculus	65-68
18968085-9	2000	The interaction with propranolol, clonidine, phenylephrine, carbachol and tripeptide fMLP, which hinder adenylate cyclase (AdC) and activate Ca-polyphosphoinisitide (Ca-PPI) signaling system of a cell, initiates structural rearrangements similar to acidic transitions of albumin.	Carbachol	60-69	albumin	Homo sapiens	271-278
11020447-4	2000	In the present paper, we showed that in 123-1N1 human astrocytoma cells, which express the G-protein-coupled M2, M3, and M5 muscarinic receptors, PKC zeta is activated by carbachol in a concentration-dependent manner, resulting in the translocation of PKC zeta from the cytoplasm to granules in the perinuclear region.	Carbachol	171-180	protein kinase C zeta	Homo sapiens	252-260
11020447-6	2000	A selective PKC zeta inhibitor peptide (peptide Z) inhibited PKC zeta translocation as well as carbachol-induced DNA synthesis.	Carbachol	95-104	protein kinase C zeta	Homo sapiens	12-20
11020447-7	2000	Inhibition of both phosphatidylinositol 3-kinase and phospholipase D decreased carbachol-induced [(3)H]thymidine incorporation and blocked carbachol-induced PKC zeta translocation, suggesting an involvement of both pathways in these effects.	Carbachol	139-148	protein kinase C zeta	Homo sapiens	157-165
11003583-6	2000	Inhibition of the carbachol response by EGF was not altered by phorbol ester-induced downregulation of protein kinase C (PKC) but was enhanced upon PKC activation by a diacylglycerol analog.	Carbachol	18-27	epidermal growth factor	Homo sapiens	40-43
11003583-1	2000	The effects of epidermal growth factor (EGF) on intracellular calcium ([Ca(2+)](i)) responses to the muscarinic agonist carbachol were studied in a human salivary cell line (HSY).	Carbachol	120-129	epidermal growth factor	Homo sapiens	15-38
11003583-7	2000	Phosphorylation of mitogen-activated protein kinase (MAP kinase) and inhibition of the carbachol response by EGF were both blocked by the MAP kinase pathway inhibitor PD-98059.	Carbachol	87-96	epidermal growth factor	Homo sapiens	109-112
11003583-1	2000	The effects of epidermal growth factor (EGF) on intracellular calcium ([Ca(2+)](i)) responses to the muscarinic agonist carbachol were studied in a human salivary cell line (HSY).	Carbachol	120-129	epidermal growth factor	Homo sapiens	40-43
11003583-8	2000	The results suggest that EGF decreases carbachol-induced Ca(2+) release from internal stores and also exerts a direct inhibitory action on Ca(2+) influx.	Carbachol	39-48	epidermal growth factor	Homo sapiens	25-28
11003583-2	2000	Carbachol (10(-4) M)-stimulated [Ca(2+)](i) mobilization was inhibited by 40% after 48-h treatment with 5 x 10(-10) M EGF.	Carbachol	0-9	epidermal growth factor	Homo sapiens	118-121
11003583-9	2000	A decline in muscarinic receptor density may contribute to EGF inhibition of carbachol responsiveness.	Carbachol	77-86	epidermal growth factor	Homo sapiens	59-62
11003583-3	2000	EGF also reduced carbachol-induced [Ca(2+)](i) in Ca(2+)-free medium and Ca(2+) influx following repletion of extracellular Ca(2+).	Carbachol	17-26	epidermal growth factor	Homo sapiens	0-3
11017921-3	2000	In this study, we show that numerous inflammatory or contractile agents, including thrombin, histamine, and carbachol, potentiate epidermal growth factor (EGF)-stimulated proliferation of human airway smooth muscle (ASM), thus demonstrating a clear synergy between RTK and GPCR activation.	Carbachol	108-117	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	273-277
11015310-6	2000	In oesophageal preparations precontracted with carbachol, thrombin produced a dual action i.e. relaxation followed by contraction.	Carbachol	47-56	coagulation factor II	Rattus norvegicus	58-66
11015294-3	2000	In N1E-115 neuroblastoma cells endogenously expressing the M(1) and M(4) receptor subtypes, MT-7 (0.3 - 3.0 nM) inhibited the carbachol (CCh)-stimulated inositol phosphates accumulation, but failed to affect the CCh-induced inhibition of pituitary adenylate cyclase activating polypeptide (PACAP) 38-stimulated cyclic AMP accumulation.	Carbachol	126-135	adenylate cyclase activating polypeptide 1	Mus musculus	290-295
11015294-3	2000	In N1E-115 neuroblastoma cells endogenously expressing the M(1) and M(4) receptor subtypes, MT-7 (0.3 - 3.0 nM) inhibited the carbachol (CCh)-stimulated inositol phosphates accumulation, but failed to affect the CCh-induced inhibition of pituitary adenylate cyclase activating polypeptide (PACAP) 38-stimulated cyclic AMP accumulation.	Carbachol	137-140	adenylate cyclase activating polypeptide 1	Mus musculus	290-295
11023534-7	2000	Exposure of HT-29 cells to carbachol, a stable receptor agonist, results in a 10-fold increase in cyclooxygenase-2 (COX-2) protein.	Carbachol	27-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	98-114
11023534-7	2000	Exposure of HT-29 cells to carbachol, a stable receptor agonist, results in a 10-fold increase in cyclooxygenase-2 (COX-2) protein.	Carbachol	27-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	116-121
10882720-5	2000	Trp1-expressing cells displayed only modest carbachol-induced Ca(2+) entry and lacked OAG-induced Sr(2+) entry, whereas Trp3-expressing cells responded to both agents with a substantial divalent cation entry.	Carbachol	44-53	transient receptor potential cation channel subfamily C member 1	Homo sapiens	0-4
11775829-4	2000	RESULTS: Both the muscarinic receptor agonist, carbachol (Carb 10 mumol/L), and anti-peptide antibodies (Abs 100 nmol/L) could decrease basal cAMP levels (by 46.9% +/- 4.2% and 60.2% +/- 4.6%, respectively) and basal Ica.	Carbachol	47-56	syntaxin 8	Homo sapiens	58-62
10882720-6	2000	Coexpression of Trp1 plus Trp3 suppressed carbachol-induced Ca(2+) entry compared with Trp3 expression and abolished OAG-induced Sr(2+) entry signals.	Carbachol	42-51	transient receptor potential cation channel subfamily C member 1	Homo sapiens	16-20
10882720-6	2000	Coexpression of Trp1 plus Trp3 suppressed carbachol-induced Ca(2+) entry compared with Trp3 expression and abolished OAG-induced Sr(2+) entry signals.	Carbachol	42-51	transient receptor potential cation channel subfamily C member 3	Homo sapiens	26-30
10971280-7	2000	RESULTS: The potency of AII was similar in child and adult detrusor strips, with mean (SEM) pD2 values of 6.9 (1.0) (n = 25) and 6.7 (0.2) (n = 9) respectively, and the maximum responses (to 10 micromol/L AII) rather low (39% and 49%, respectively, P &gt; 0.05), compared with carbachol (100 micromol/L).	Carbachol	277-286	NLR family pyrin domain containing 3	Homo sapiens	24-27
10956273-6	2000	Bladder strips from cGKI-/- mice responded normally to electrical field stimulation and to carbachol but not to 8-BrcGMP.	Carbachol	91-100	protein kinase, cGMP-dependent, type I	Mus musculus	20-24
10960062-3	2000	However, there were regional differences in the efficacy of hU-II, with a progressive increase in the maximum contraction from trachea to smaller airway regions (from 9 to 41% of the contraction to 10 microM carbachol).	Carbachol	208-217	urotensin 2	Homo sapiens	60-65
10944110-7	2000	Finally, repeated carbachol stimulations of mAchRs co-expressed in COS cells with endothelial nitric oxide synthase (eNOS) and wild-type, but not mutant, dynamin led to a progressive increase in mAchR sequestration and a concurrent stabilization of the inhibitory eNOS-caveolin complex.	Carbachol	18-27	nitric oxide synthase 3	Homo sapiens	82-115
10965900-3	2000	Wortmannin amplified insulin release induced by the combination of 6-8 mM glucose plus 1 microM carbachol; however, it had no effect on phorbol ester- or alpha-ketoisocaproate-induced insulin secretion.	Carbachol	96-105	insulin	Homo sapiens	21-28
10945862-3	2000	The PTX-sensitive GPC mitogens carbachol and endothelin-1 and the PTX-insensitive GPC mitogens sphingosine-1-phosphate and thrombin exhibited synergistic stimulation together with EGF.	Carbachol	31-40	glycophorin C (Gerbich blood group)	Homo sapiens	18-21
10953050-6	2000	Although RGS14 does not act as a GAP for G12/13alpha, it impairs c-fos serum response element activation induced by either a constitutively active mutant of G13alpha (G13alphaQ226L) or by carbachol stimulation of muscarinic type 1 receptors.	Carbachol	188-197	regulator of G-protein signaling 14	Mus musculus	9-14
11032727-7	2000	It was found that cell proliferation, viability, insulin production and the stimulation of insulin release evoked by carbamylcholine and phorbol ester were impeded by IL-1beta or spermine-NONOate, whereas the hormone output by the other secretagogues was not altered by NO.	Carbachol	117-132	interleukin 1 beta	Rattus norvegicus	167-175
10801833-10	2000	Thus, the inhibitory effect of EGF on carbachol-induced chloride secretion involves the activation of PKCepsilon mediated by PI 3-kinase.	Carbachol	38-47	protein kinase C epsilon	Homo sapiens	102-112
10924670-7	2000	Our data suggest that activation of CaMKII by carbachol is crucial for local theta-like activity in the CA1 area of the rat hippocampus in vitro.	Carbachol	46-55	carbonic anhydrase 1	Rattus norvegicus	104-107
10934239-4	2000	Although carbachol did not enhance ISO-induced increases in cAMP, coapplication of ISO and carbachol synergistically activated p42 mitogen-activated protein kinase (p42 MAPK).	Carbachol	91-100	mitogen-activated protein kinase 1	Homo sapiens	127-163
10934239-4	2000	Although carbachol did not enhance ISO-induced increases in cAMP, coapplication of ISO and carbachol synergistically activated p42 mitogen-activated protein kinase (p42 MAPK).	Carbachol	91-100	mitogen-activated protein kinase 1	Homo sapiens	165-173
10926555-2	2000	We have shown previously that TNF-alpha upregulates the expression of Galpha(i-2) protein without significantly increasing G(s)alpha protein and enhances adenylyl cyclase inhibition by carbachol in cultured human airway smooth muscle cells (Hotta K, Emala CW, and Hirshman CA.	Carbachol	185-194	tumor necrosis factor	Homo sapiens	30-39
10801833-1	2000	Epidermal growth factor (EGF) inhibits carbachol-induced chloride secretion in T(84) colonic epithelial cells and has been shown to activate phosphatidylinositol (PI) 3-kinase, leading to inhibition of a basolateral potassium conductance.	Carbachol	39-48	epidermal growth factor	Homo sapiens	0-23
10801833-1	2000	Epidermal growth factor (EGF) inhibits carbachol-induced chloride secretion in T(84) colonic epithelial cells and has been shown to activate phosphatidylinositol (PI) 3-kinase, leading to inhibition of a basolateral potassium conductance.	Carbachol	39-48	epidermal growth factor	Homo sapiens	25-28
10787424-8	2000	Adenovirus-directed overexpression of the human beta(2)-AR results in elevated base-line cAMP and contraction associated with a marked attenuation of beta(1)-AR response; carbachol pretreatment fully revives the diminished beta(1)-AR contractile response.	Carbachol	171-180	adrenoceptor beta 2	Homo sapiens	48-58
10959486-3	2000	On the other hand, SIN-1 reduced carbachol-induced inositol 1,4,5-trisphosphate (IP3) formation.	Carbachol	33-42	MAPK associated protein 1	Homo sapiens	19-24
10787424-8	2000	Adenovirus-directed overexpression of the human beta(2)-AR results in elevated base-line cAMP and contraction associated with a marked attenuation of beta(1)-AR response; carbachol pretreatment fully revives the diminished beta(1)-AR contractile response.	Carbachol	171-180	adrenoceptor beta 1	Homo sapiens	150-160
10787424-8	2000	Adenovirus-directed overexpression of the human beta(2)-AR results in elevated base-line cAMP and contraction associated with a marked attenuation of beta(1)-AR response; carbachol pretreatment fully revives the diminished beta(1)-AR contractile response.	Carbachol	171-180	adrenoceptor beta 1	Homo sapiens	223-233
10801833-9	2000	Antisense oligonucleotides against PKCepsilon decreased PKCepsilon mass and prevented the inhibitory effect of EGF on carbachol-induced (86)Rb(+) efflux.	Carbachol	118-127	epidermal growth factor	Homo sapiens	111-114
10801833-10	2000	Thus, the inhibitory effect of EGF on carbachol-induced chloride secretion involves the activation of PKCepsilon mediated by PI 3-kinase.	Carbachol	38-47	epidermal growth factor	Homo sapiens	31-34
10860637-1	2000	In this study we examined the mechanism of the concentration-dependent relaxant effect of angiotensin II (A II) on mouse isolated tracheal rings precontracted by carbachol.	Carbachol	162-171	arginase type II	Mus musculus	90-104
10852825-9	2000	Similarly, in RBL-2H3 cells that stably express physiological levels of m1AChR, the addition of carbachol selectively induces the localization of arrestin-3, but not arrestin-2, to coated pits.	Carbachol	96-105	arrestin 3	Rattus norvegicus	146-156
10860637-1	2000	In this study we examined the mechanism of the concentration-dependent relaxant effect of angiotensin II (A II) on mouse isolated tracheal rings precontracted by carbachol.	Carbachol	162-171	arginase type II	Mus musculus	106-110
10860637-6	2000	K(+)-channel blockers partially inhibited the relaxant effect of A II in carbachol-precontracted mouse tracheal rings.	Carbachol	73-82	arginase type II	Mus musculus	65-69
10860637-9	2000	These results suggest that the mechanisms, involved in the relaxation induced by A II in the isolated mouse tracheal rings precontracted by carbachol, were firstly l -arginine NO and cyclo-oxygenase products of arachidonic acid, secondly K(+)channels.	Carbachol	140-149	arginase type II	Mus musculus	81-85
10833448-3	2000	We studied whether islet phospholipase A(2) (PLA(2)) contributes by using C57BL/6J mice fed a high-fat diet, since we previously showed that the insulin responses to the two PLA(2)-activating insulin secretagogues carbachol and cholecystokinin (CCK) are enhanced in this model.	Carbachol	214-223	phospholipase A2, group IB, pancreas	Mus musculus	174-180
10770956-9	2000	Carbachol also activated p38 kinase, and the protective effect of carbachol was abolished by SB-202190.	Carbachol	0-9	mitogen activated protein kinase 14	Rattus norvegicus	25-28
10748023-8	2000	Interestingly, NHERF2 potentiated the PLC-beta activation by carbachol in COS7 and HeLa cells, while mutant NHERF2, lacking the second PDZ domain, had no such effect.	Carbachol	61-70	SLC9A3 regulator 2	Homo sapiens	15-21
10838169-9	2000	In separate studies that used peptide gamma, CCK-8, CCh and CCK-OPE dose-dependently increased CaMKIV activities.	Carbachol	52-55	calcium/calmodulin-dependent protein kinase IV	Rattus norvegicus	95-101
10838169-13	2000	CCK-8, CCh and CCK-OPE also significantly increased phosphotransferase activities of myosin light chain kinase (MLCK) substrate (basal: 4.4+/-0.7 pmol/min/mg protein).	Carbachol	7-10	myosin light chain kinase	Rattus norvegicus	85-110
10838169-13	2000	CCK-8, CCh and CCK-OPE also significantly increased phosphotransferase activities of myosin light chain kinase (MLCK) substrate (basal: 4.4+/-0.7 pmol/min/mg protein).	Carbachol	7-10	myosin light chain kinase	Rattus norvegicus	112-116
10839927-0	2000	Halothane and isoflurane augment depolarization-induced cytosolic CA2+ transients and attenuate carbachol-stimulated CA2+ transients.	Carbachol	96-105	carbonic anhydrase 2	Homo sapiens	117-120
10839927-3	2000	Using a human neuroblastoma cell line, the effects of halothane and isoflurane on cytosolic Ca2+ concentration ([Ca2+]cyt) in response to K+ and carbachol stimulation were investigated.	Carbachol	145-154	carbonic anhydrase 2	Homo sapiens	92-95
10839927-3	2000	Using a human neuroblastoma cell line, the effects of halothane and isoflurane on cytosolic Ca2+ concentration ([Ca2+]cyt) in response to K+ and carbachol stimulation were investigated.	Carbachol	145-154	carbonic anhydrase 2	Homo sapiens	113-116
10839927-8	2000	In contrast, halothane and isoflurane reduced the carbachol-evoked [Ca2+]cyt transient when the intracellular Ca2+ stores were full but had no effect when the Ca2+ stores were partially depleted by KCl stimulation.	Carbachol	50-59	carbonic anhydrase 2	Homo sapiens	68-71
10839927-8	2000	In contrast, halothane and isoflurane reduced the carbachol-evoked [Ca2+]cyt transient when the intracellular Ca2+ stores were full but had no effect when the Ca2+ stores were partially depleted by KCl stimulation.	Carbachol	50-59	carbonic anhydrase 2	Homo sapiens	110-113
10839927-8	2000	In contrast, halothane and isoflurane reduced the carbachol-evoked [Ca2+]cyt transient when the intracellular Ca2+ stores were full but had no effect when the Ca2+ stores were partially depleted by KCl stimulation.	Carbachol	50-59	carbonic anhydrase 2	Homo sapiens	110-113
10839927-9	2000	CONCLUSIONS: Volatile anesthetics acted on sites that differently affect the K+- and carbachol-evoked [Ca2+]cyt transients.	Carbachol	85-94	carbonic anhydrase 2	Homo sapiens	103-106
10816433-1	2000	The acetylcholine analogue carbachol rapidly activated mitogen-activated protein kinase (MAPK), and caused tyrosine phosphorylation of the adapter protein p52 Shc and the epidermalgrowth factor (EGF) receptor, in human embryonic kidney cells stably expressing m3 muscarinic receptors.	Carbachol	27-36	SHC adaptor protein 1	Homo sapiens	159-162
10816433-1	2000	The acetylcholine analogue carbachol rapidly activated mitogen-activated protein kinase (MAPK), and caused tyrosine phosphorylation of the adapter protein p52 Shc and the epidermalgrowth factor (EGF) receptor, in human embryonic kidney cells stably expressing m3 muscarinic receptors.	Carbachol	27-36	epidermal growth factor receptor	Homo sapiens	171-208
10816433-3	2000	The PKC-independent MAPK activity elicited by carbachol in the presence of GF109203X was reproducibly abolished by AG1478, an inhibitor of EGF-receptor tyrosine kinase activity, and by the Src tyrosine kinase inhibitor PP1.	Carbachol	46-55	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	189-192
10816433-3	2000	The PKC-independent MAPK activity elicited by carbachol in the presence of GF109203X was reproducibly abolished by AG1478, an inhibitor of EGF-receptor tyrosine kinase activity, and by the Src tyrosine kinase inhibitor PP1.	Carbachol	46-55	neuropeptide Y receptor Y4	Homo sapiens	219-222
10816433-4	2000	In a subset of these experiments, GF109203X concomitantly increased carbachol-induced tyrosine phosphorylation of p52 Shc and the EGF receptor.	Carbachol	68-77	SHC adaptor protein 1	Homo sapiens	118-121
10816433-4	2000	In a subset of these experiments, GF109203X concomitantly increased carbachol-induced tyrosine phosphorylation of p52 Shc and the EGF receptor.	Carbachol	68-77	epidermal growth factor receptor	Homo sapiens	130-142
10816433-5	2000	In co-stimulation experiments, carbachol and EGF activated MAPK in a non-additive fashion; moreover, EGF-induced association of Shc with the phosphorylated EGF receptor was inhibited by carbachol.	Carbachol	31-40	SHC adaptor protein 1	Homo sapiens	128-131
10816433-5	2000	In co-stimulation experiments, carbachol and EGF activated MAPK in a non-additive fashion; moreover, EGF-induced association of Shc with the phosphorylated EGF receptor was inhibited by carbachol.	Carbachol	31-40	epidermal growth factor receptor	Homo sapiens	156-168
10816433-5	2000	In co-stimulation experiments, carbachol and EGF activated MAPK in a non-additive fashion; moreover, EGF-induced association of Shc with the phosphorylated EGF receptor was inhibited by carbachol.	Carbachol	186-195	SHC adaptor protein 1	Homo sapiens	128-131
10816433-5	2000	In co-stimulation experiments, carbachol and EGF activated MAPK in a non-additive fashion; moreover, EGF-induced association of Shc with the phosphorylated EGF receptor was inhibited by carbachol.	Carbachol	186-195	epidermal growth factor receptor	Homo sapiens	156-168
10936763-2	2000	Carbachol stimulated gastrin release in a dose-dependent manner but had no effect on somatostatin release.	Carbachol	0-9	gastrin	Homo sapiens	21-28
10936763-3	2000	As atropine blocked the effect of carbachol, cholinergic agonists appear to stimulate gastrin secretion directly through muscarinic receptors on the G-cell and not by inhibition of somatostatin secretion.	Carbachol	34-43	gastrin	Homo sapiens	86-93
11014771-0	2000	Carbachol potentiates cholera toxin-induced secretion in a colonic epithelial cell line (HT29-19A) and rat ileal mucosa in vitro.	Carbachol	0-9	SLAM family member 7	Homo sapiens	94-97
11014771-5	2000	Pre-treatment of the HT29-19A cell lines with carbachol potentiated cholera toxin-induced secretory response, and enhanced accumulation of cAMP.	Carbachol	46-55	SLAM family member 7	Homo sapiens	26-29
10848561-9	2000	Verruculogen (100 nM), carbachol (100 microM), apamin (100 nM), TEA (1 mM), and iberiotoxin (50 nM) significantly reduced early I(K(Ca)) on CA1 pyramidal neurons; early I(K(Ca)) on L-M interneurons was inhibited by apamin and TEA.	Carbachol	23-32	carbonic anhydrase 1	Rattus norvegicus	140-143
10833448-4	2000	CCK (100 nM) and carbachol (100 microM) stimulated [(3)H]AA efflux, reflecting PLA(2) activation, both in islets from mice after 12 weeks on high-fat diet and in controls.	Carbachol	17-26	phospholipase A2, group IB, pancreas	Mus musculus	79-85
10775445-4	2000	Results show that stimulation of pancreatic acini with carbachol resulted in a rapid and transient increase in tyrosine phosphorylation of p125(FAK), p130(cas), and paxillin.	Carbachol	55-64	protein tyrosine kinase 2	Rattus norvegicus	144-147
10799557-7	2000	Interestingly, treatment of acini from AC8-KO mice with agents, i.e. carbachol and thapsigargin that increase intracellular Ca(2+), lowered cAMP levels.	Carbachol	69-78	adenylate cyclase 8	Mus musculus	39-42
10775445-4	2000	Results show that stimulation of pancreatic acini with carbachol resulted in a rapid and transient increase in tyrosine phosphorylation of p125(FAK), p130(cas), and paxillin.	Carbachol	55-64	phospholipase C-like 1	Rattus norvegicus	150-154
10775445-7	2000	Pretreatment of pancreatic acini with Clostridium botulinum C3 transferase, which specifically inactivates p21(rho), partially inhibited carbachol-induced p125(FAK), p130(cas), and paxillin tyrosine phosphorylation.	Carbachol	137-146	KRAS proto-oncogene, GTPase	Rattus norvegicus	107-110
10775445-7	2000	Pretreatment of pancreatic acini with Clostridium botulinum C3 transferase, which specifically inactivates p21(rho), partially inhibited carbachol-induced p125(FAK), p130(cas), and paxillin tyrosine phosphorylation.	Carbachol	137-146	protein tyrosine kinase 2	Rattus norvegicus	160-163
10775445-7	2000	Pretreatment of pancreatic acini with Clostridium botulinum C3 transferase, which specifically inactivates p21(rho), partially inhibited carbachol-induced p125(FAK), p130(cas), and paxillin tyrosine phosphorylation.	Carbachol	137-146	phospholipase C-like 1	Rattus norvegicus	166-170
10813386-2	2000	Pretreatment with C3 exoenzyme of Clostridium botulinum, which selectively inactivates rho p21 by adenosine diphosphate (ADP) ribosylation, resulted in a significant inhibition of ET-1-induced Ca2+ sensitization, but had no effect on carbachol-induced Ca2+ sensitization.	Carbachol	234-243	endothelin-1	Oryctolagus cuniculus	180-184
10777795-1	2000	In the present study, we report that the cuneiform (Cun) nucleus, a brainstem structure that before now has not been implicated in sleep processes, exhibits a large number of neurons that express c-fos during carbachol-induced active sleep (AS-carbachol).	Carbachol	209-218	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	196-201
10959486-1	2000	We have investigated the effect of 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, on carbachol-induced increase in intracellular Ca2+ concentration ([Ca2+]i) in human neuroblastoma SH-SY5Y cells by means of single cell imaging of [Ca2+]i.	Carbachol	94-103	MAPK associated protein 1	Homo sapiens	60-65
10959486-2	2000	SIN-1 potentiated carbachol-induced [Ca2+]i rise regardless of external Ca2+, and the potentiation was completely inhibited by superoxide dismutase, indicating that peroxynitrite may enhance Ca2+ release from intracellular stores.	Carbachol	18-27	MAPK associated protein 1	Homo sapiens	0-5
10800946-3	2000	The carbachol-induced arachidonate release is potentiated two- to threefold by pretreatment of A2058 cells with either of the inflammatory cytokines, tumor necrosis factor-alpha or interleukin-1beta .	Carbachol	4-13	tumor necrosis factor	Homo sapiens	150-177
10800946-3	2000	The carbachol-induced arachidonate release is potentiated two- to threefold by pretreatment of A2058 cells with either of the inflammatory cytokines, tumor necrosis factor-alpha or interleukin-1beta .	Carbachol	4-13	interleukin 1 beta	Homo sapiens	181-198
10777553-8	2000	CCh also induced tyrosine phosphorylation of p60(src) and association of p60(src) with both PYK-2 and the EGFR.	Carbachol	0-3	protein tyrosine kinase 2 beta	Homo sapiens	92-97
10777553-9	2000	The Src family kinase inhibitor, PP2 (20 nM-20 microM) attenuated CCh-stimulated EGFR and ERK phosphorylation and potentiated chloride secretory responses to CCh.	Carbachol	66-69	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	33-36
10777553-0	2000	Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src).	Carbachol	0-9	epidermal growth factor receptor	Homo sapiens	40-72
10777553-0	2000	Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src).	Carbachol	0-9	protein tyrosine kinase 2 beta	Homo sapiens	160-165
10777553-0	2000	Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src).	Carbachol	0-9	sequestosome 1	Homo sapiens	171-174
10777553-9	2000	The Src family kinase inhibitor, PP2 (20 nM-20 microM) attenuated CCh-stimulated EGFR and ERK phosphorylation and potentiated chloride secretory responses to CCh.	Carbachol	66-69	epidermal growth factor receptor	Homo sapiens	81-85
10777553-0	2000	Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src).	Carbachol	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	175-178
10777553-9	2000	The Src family kinase inhibitor, PP2 (20 nM-20 microM) attenuated CCh-stimulated EGFR and ERK phosphorylation and potentiated chloride secretory responses to CCh.	Carbachol	66-69	mitogen-activated protein kinase 1	Homo sapiens	90-93
10777553-1	2000	Ca(2+)-dependent agonists, such as carbachol (CCh), stimulate epidermal growth factor receptor (EGFR) transactivation and mitogen-activated protein kinase activation in T(84) intestinal epithelial cells.	Carbachol	35-44	epidermal growth factor receptor	Homo sapiens	62-94
10777553-1	2000	Ca(2+)-dependent agonists, such as carbachol (CCh), stimulate epidermal growth factor receptor (EGFR) transactivation and mitogen-activated protein kinase activation in T(84) intestinal epithelial cells.	Carbachol	35-44	epidermal growth factor receptor	Homo sapiens	96-100
10779394-3	2000	Studies to test whether the selective enhancement in beta-adrenergic receptor (AR) response might result from inhibition of AC6 by Galpha(i) and Gbetagamma indicated that pertussis toxin-sensitive inhibition by the muscarinic cholinergic agonist carbachol was unaltered in myocytes overexpressing AC6.	Carbachol	246-255	adenylate cyclase 6	Homo sapiens	124-127
10777553-9	2000	The Src family kinase inhibitor, PP2 (20 nM-20 microM) attenuated CCh-stimulated EGFR and ERK phosphorylation and potentiated chloride secretory responses to CCh.	Carbachol	158-161	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	4-7
10777553-1	2000	Ca(2+)-dependent agonists, such as carbachol (CCh), stimulate epidermal growth factor receptor (EGFR) transactivation and mitogen-activated protein kinase activation in T(84) intestinal epithelial cells.	Carbachol	46-49	epidermal growth factor receptor	Homo sapiens	62-94
10777553-1	2000	Ca(2+)-dependent agonists, such as carbachol (CCh), stimulate epidermal growth factor receptor (EGFR) transactivation and mitogen-activated protein kinase activation in T(84) intestinal epithelial cells.	Carbachol	46-49	epidermal growth factor receptor	Homo sapiens	96-100
10777553-9	2000	The Src family kinase inhibitor, PP2 (20 nM-20 microM) attenuated CCh-stimulated EGFR and ERK phosphorylation and potentiated chloride secretory responses to CCh.	Carbachol	158-161	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	33-36
10777553-3	2000	Here, we investigated mechanisms underlying CCh-stimulated epidermal growth factor receptor (EGFR) transactivation.	Carbachol	44-47	epidermal growth factor receptor	Homo sapiens	59-91
10777553-3	2000	Here, we investigated mechanisms underlying CCh-stimulated epidermal growth factor receptor (EGFR) transactivation.	Carbachol	44-47	epidermal growth factor receptor	Homo sapiens	93-97
10777553-6	2000	CCh (100 microM) stimulated tyrosine phosphorylation and association of the Ca(2+)-dependent tyrosine kinase, PYK-2, with the EGFR, which was inhibited by the Ca(2+) chelator, BAPTA (20 microM).	Carbachol	0-3	protein tyrosine kinase 2 beta	Homo sapiens	110-115
10777553-6	2000	CCh (100 microM) stimulated tyrosine phosphorylation and association of the Ca(2+)-dependent tyrosine kinase, PYK-2, with the EGFR, which was inhibited by the Ca(2+) chelator, BAPTA (20 microM).	Carbachol	0-3	epidermal growth factor receptor	Homo sapiens	126-130
10777553-7	2000	The calmodulin inhibitor, fluphenazine (50 microM) inhibited CCh-stimulated PYK-2 association with the EGFR and phosphorylation of EGFR and ERK.	Carbachol	61-64	calmodulin 1	Homo sapiens	4-14
10777553-10	2000	We conclude that CCh-stimulated transactivation of the EGFR is mediated by a pathway involving elevations in intracellular Ca(2+), calmodulin, PYK-2, and p60(src).	Carbachol	17-20	epidermal growth factor receptor	Homo sapiens	55-59
10777553-10	2000	We conclude that CCh-stimulated transactivation of the EGFR is mediated by a pathway involving elevations in intracellular Ca(2+), calmodulin, PYK-2, and p60(src).	Carbachol	17-20	calmodulin 1	Homo sapiens	131-141
10777553-10	2000	We conclude that CCh-stimulated transactivation of the EGFR is mediated by a pathway involving elevations in intracellular Ca(2+), calmodulin, PYK-2, and p60(src).	Carbachol	17-20	protein tyrosine kinase 2 beta	Homo sapiens	143-148
10777553-10	2000	We conclude that CCh-stimulated transactivation of the EGFR is mediated by a pathway involving elevations in intracellular Ca(2+), calmodulin, PYK-2, and p60(src).	Carbachol	17-20	sequestosome 1	Homo sapiens	154-157
10777553-10	2000	We conclude that CCh-stimulated transactivation of the EGFR is mediated by a pathway involving elevations in intracellular Ca(2+), calmodulin, PYK-2, and p60(src).	Carbachol	17-20	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	158-161
10777553-7	2000	The calmodulin inhibitor, fluphenazine (50 microM) inhibited CCh-stimulated PYK-2 association with the EGFR and phosphorylation of EGFR and ERK.	Carbachol	61-64	protein tyrosine kinase 2 beta	Homo sapiens	76-81
10758335-3	2000	The results showed that (1) simultaneous incubation with carbachol dose- and time-dependently blocked the specific DNA ladder formation induced by exposure to A(beta31-35) and (2) the A(beta31-35)-induced downregulation of bcl-2 and upregulations of bax, p53, and c-fos genes were reversed or ameliorated by the coadministration of carbachol.	Carbachol	57-66	B cell leukemia/lymphoma 2	Mus musculus	223-228
10777553-7	2000	The calmodulin inhibitor, fluphenazine (50 microM) inhibited CCh-stimulated PYK-2 association with the EGFR and phosphorylation of EGFR and ERK.	Carbachol	61-64	epidermal growth factor receptor	Homo sapiens	103-107
10777553-7	2000	The calmodulin inhibitor, fluphenazine (50 microM) inhibited CCh-stimulated PYK-2 association with the EGFR and phosphorylation of EGFR and ERK.	Carbachol	61-64	epidermal growth factor receptor	Homo sapiens	131-135
10777553-7	2000	The calmodulin inhibitor, fluphenazine (50 microM) inhibited CCh-stimulated PYK-2 association with the EGFR and phosphorylation of EGFR and ERK.	Carbachol	61-64	mitogen-activated protein kinase 1	Homo sapiens	140-143
10777553-8	2000	CCh also induced tyrosine phosphorylation of p60(src) and association of p60(src) with both PYK-2 and the EGFR.	Carbachol	0-3	sequestosome 1	Homo sapiens	45-48
10777553-8	2000	CCh also induced tyrosine phosphorylation of p60(src) and association of p60(src) with both PYK-2 and the EGFR.	Carbachol	0-3	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-52
10777553-8	2000	CCh also induced tyrosine phosphorylation of p60(src) and association of p60(src) with both PYK-2 and the EGFR.	Carbachol	0-3	sequestosome 1	Homo sapiens	73-76
10777553-8	2000	CCh also induced tyrosine phosphorylation of p60(src) and association of p60(src) with both PYK-2 and the EGFR.	Carbachol	0-3	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	77-80
10777553-8	2000	CCh also induced tyrosine phosphorylation of p60(src) and association of p60(src) with both PYK-2 and the EGFR.	Carbachol	0-3	epidermal growth factor receptor	Homo sapiens	106-110
10777553-9	2000	The Src family kinase inhibitor, PP2 (20 nM-20 microM) attenuated CCh-stimulated EGFR and ERK phosphorylation and potentiated chloride secretory responses to CCh.	Carbachol	66-69	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	4-7
10751428-4	2000	Tubulin, at nanomolar concentrations, transactivated Galphaq by the direct transfer of a GTP analog and potentiated carbachol-activated PLCbeta(1).	Carbachol	116-125	phospholipase C beta 1	Homo sapiens	136-146
10751321-7	2000	Carbachol stimulation increased caldesmon phosphorylation at Ser789 in intact tracheal smooth muscle, which was blocked by the M(2) antagonist AF-DX 116 (1 microM).	Carbachol	0-9	caldesmon 1	Homo sapiens	32-41
10840221-6	2000	In the colon, while SST inhibited the carbachol induced increase in I(sc), pre-treatment with tetrodotoxin (750 nM) profoundly inhibited the carbachol induced increase in I(sc), thus markedly reducing the inhibitory effect of SST.	Carbachol	38-47	somatostatin	Mus musculus	20-23
10840221-6	2000	In the colon, while SST inhibited the carbachol induced increase in I(sc), pre-treatment with tetrodotoxin (750 nM) profoundly inhibited the carbachol induced increase in I(sc), thus markedly reducing the inhibitory effect of SST.	Carbachol	141-150	somatostatin	Mus musculus	226-229
10752952-1	2000	PURPOSE: To determine the cholinergic (carbachol, CCH) and adrenergic (norepinephrine, NE) modulation of Ca2+ response to endothelin-1 in human ciliary smooth muscle (HCSM) cells.	Carbachol	39-48	endothelin 1	Homo sapiens	122-134
10752952-5	2000	Carbachol also dose-dependently increased [Ca2+]i; however, subsequent additions of ET-1 (200 nM) resulted in lower [Ca2+]i (100 microM CCH + ET-1; 300 +/- 21 nM) compared with that observed with 200 nM ET-1 alone (2564 +/- 359 nM).	Carbachol	0-9	endothelin 1	Homo sapiens	84-88
10752952-5	2000	Carbachol also dose-dependently increased [Ca2+]i; however, subsequent additions of ET-1 (200 nM) resulted in lower [Ca2+]i (100 microM CCH + ET-1; 300 +/- 21 nM) compared with that observed with 200 nM ET-1 alone (2564 +/- 359 nM).	Carbachol	0-9	endothelin 1	Homo sapiens	142-146
10752952-5	2000	Carbachol also dose-dependently increased [Ca2+]i; however, subsequent additions of ET-1 (200 nM) resulted in lower [Ca2+]i (100 microM CCH + ET-1; 300 +/- 21 nM) compared with that observed with 200 nM ET-1 alone (2564 +/- 359 nM).	Carbachol	0-9	endothelin 1	Homo sapiens	142-146
10752933-8	2000	Similarly, cAMP increased by 9%, 70%, and 210% in response to 10(-9), 10(-7), and 10(-5) M carbachol, respectively.	Carbachol	91-100	cathelicidin antimicrobial peptide	Homo sapiens	11-15
10752933-9	2000	In addition, cAMP levels significantly increased by 39% in isolated TM strips incubated with 10(-7) M carbachol.	Carbachol	102-111	cathelicidin antimicrobial peptide	Homo sapiens	13-17
10702271-7	2000	Activation of Pyk2 via the muscarinic and nicotinic receptors using carbachol or via intracellular Ca(2+) rise using ionomycin/phorbol myristate acetate promoted survival in the absence of IL-7.	Carbachol	68-77	PTK2 protein tyrosine kinase 2 beta	Mus musculus	14-18
10758335-3	2000	The results showed that (1) simultaneous incubation with carbachol dose- and time-dependently blocked the specific DNA ladder formation induced by exposure to A(beta31-35) and (2) the A(beta31-35)-induced downregulation of bcl-2 and upregulations of bax, p53, and c-fos genes were reversed or ameliorated by the coadministration of carbachol.	Carbachol	57-66	BCL2-associated X protein	Mus musculus	250-253
10758335-3	2000	The results showed that (1) simultaneous incubation with carbachol dose- and time-dependently blocked the specific DNA ladder formation induced by exposure to A(beta31-35) and (2) the A(beta31-35)-induced downregulation of bcl-2 and upregulations of bax, p53, and c-fos genes were reversed or ameliorated by the coadministration of carbachol.	Carbachol	57-66	transformation related protein 53, pseudogene	Mus musculus	255-258
10683200-2	2000	VIP induced a concentration-dependent inhibition of carbachol-induced contraction in smooth muscle cells with a maximum at 10(-6) M. The relaxation by 10(-6) M VIP was inhibited for 79.1+/-5.8% (mean+/-s.e.	Carbachol	52-61	VIP peptides	Cavia porcellus	0-3
10712234-7	2000	However, the secretory response to the muscarinic receptor agonist carbachol was strongly increased after exposure to TNF-alpha.	Carbachol	67-76	tumor necrosis factor	Homo sapiens	118-127
10712234-8	2000	Application of the protein kinase C (PKC) inhibitor GF 109203X (bisindolylmaleimide I) inhibited the response to carbachol as well as the TNF-alpha-potentiated response, indicating that PKC mediates the effect of carbachol in this cell line.	Carbachol	213-222	tumor necrosis factor	Homo sapiens	138-147
10704824-3	2000	Addition of carbachol or CCK-8 to pancreatic acini resulted in rapid increases in the tyrosine phosphorylation of p125(FAK), p130(Cas), and paxillin.	Carbachol	12-21	protein tyrosine kinase 2	Rattus norvegicus	119-122
10704824-3	2000	Addition of carbachol or CCK-8 to pancreatic acini resulted in rapid increases in the tyrosine phosphorylation of p125(FAK), p130(Cas), and paxillin.	Carbachol	12-21	phospholipase C-like 1	Rattus norvegicus	125-129
10758335-3	2000	The results showed that (1) simultaneous incubation with carbachol dose- and time-dependently blocked the specific DNA ladder formation induced by exposure to A(beta31-35) and (2) the A(beta31-35)-induced downregulation of bcl-2 and upregulations of bax, p53, and c-fos genes were reversed or ameliorated by the coadministration of carbachol.	Carbachol	57-66	FBJ osteosarcoma oncogene	Mus musculus	264-269
10758335-3	2000	The results showed that (1) simultaneous incubation with carbachol dose- and time-dependently blocked the specific DNA ladder formation induced by exposure to A(beta31-35) and (2) the A(beta31-35)-induced downregulation of bcl-2 and upregulations of bax, p53, and c-fos genes were reversed or ameliorated by the coadministration of carbachol.	Carbachol	332-341	B cell leukemia/lymphoma 2	Mus musculus	223-228
10670466-3	2000	RESULTS: Preactivation of PKC by phorbol 12-myristate 13-acetate (PMA), or inhibition of protein phosphatase type 1/2A (PP1/2A) by calyculin A, decreased both the [Ca2+]i transient and the plateau of [Ca2+]i induced by increasing concentrations of carbachol, a cholinergic agonist.	Carbachol	248-257	neuropeptide Y receptor Y4	Rattus norvegicus	120-126
10676879-3	2000	Exposure of granule cells from wild-type or tenascin-C-negative mice to the muscarinic acetylcholine receptor agonist carbachol (1 mM) resulted in normal sequestration of cell-surface muscarinic acetylcholine receptors as assessed by [3H]N-methylscopolamine binding; however, down-regulation of total muscarinic acetylcholine receptors, measured with [3H]quinuclidinyl benzilate, was inhibited in granule cells from tenascin-C-negative mice.	Carbachol	118-127	tenascin C	Mus musculus	44-52
10676879-3	2000	Exposure of granule cells from wild-type or tenascin-C-negative mice to the muscarinic acetylcholine receptor agonist carbachol (1 mM) resulted in normal sequestration of cell-surface muscarinic acetylcholine receptors as assessed by [3H]N-methylscopolamine binding; however, down-regulation of total muscarinic acetylcholine receptors, measured with [3H]quinuclidinyl benzilate, was inhibited in granule cells from tenascin-C-negative mice.	Carbachol	118-127	tenascin C	Mus musculus	416-424
10685865-4	2000	Stimulation with low concentrations of carbachol or cholecystokinin octapeptide (CCK-8) induces [Ca2+]i oscillations whereas higher concentrations cause sustained elevation of [Ca2+]i.	Carbachol	39-48	cholecystokinin	Cavia porcellus	81-84
10786716-5	2000	Prolonged exposure to a sublethal dose of A(beta) 25-35 or 1-42 disrupted carbachol-mediated release of Ins(1,4,5)P3 and [Ca2+]i, which was inhibited in media supplemented with B27 or the antioxidant vitamin E.	Carbachol	74-83	amyloid beta precursor protein	Rattus norvegicus	42-49
10636879-1	2000	In HEK 293 cells stably expressing type 1 parathyroid (PTH) receptors, PTH stimulated release of intracellular Ca(2+) stores in only 27% of cells, whereas 96% of cells responded to carbachol.	Carbachol	181-190	parathyroid hormone	Homo sapiens	55-58
10636879-2	2000	However, in almost all cells PTH potentiated the response to carbachol by about 3-fold.	Carbachol	61-70	parathyroid hormone	Homo sapiens	29-32
10636879-6	2000	Intracellular heparin inhibited responses to carbachol and PTH, and pretreatment with ATP and carbachol abolished responses to PTH, suggesting that the effects of PTH involve inositol trisphosphate (IP(3)) receptors.	Carbachol	94-103	parathyroid hormone	Homo sapiens	127-130
10636879-6	2000	Intracellular heparin inhibited responses to carbachol and PTH, and pretreatment with ATP and carbachol abolished responses to PTH, suggesting that the effects of PTH involve inositol trisphosphate (IP(3)) receptors.	Carbachol	94-103	parathyroid hormone	Homo sapiens	127-130
10683200-2	2000	VIP induced a concentration-dependent inhibition of carbachol-induced contraction in smooth muscle cells with a maximum at 10(-6) M. The relaxation by 10(-6) M VIP was inhibited for 79.1+/-5.8% (mean+/-s.e.	Carbachol	52-61	VIP peptides	Cavia porcellus	160-163
10652198-5	2000	The potency and efficacy to carbachol in the presence of (-)-isoprenaline were higher in right atria from mdx compared to C57 mice (P&lt;0.05), although in left atria only a greater efficacy was evident in mdx mice.	Carbachol	28-37	dystrophin, muscular dystrophy	Mus musculus	106-109
10651876-5	2000	Both Ca2+ and PKC responses were observed within seconds following KCl or carbachol application, and were reversible upon stimulus withdrawal.	Carbachol	74-83	protein kinase C, gamma	Rattus norvegicus	14-17
10902895-11	2000	2) Carbachol induces IPSC activity that can be recorded in CA1 and CA3a.	Carbachol	3-12	carbonic anhydrase 1	Rattus norvegicus	59-62
10652198-5	2000	The potency and efficacy to carbachol in the presence of (-)-isoprenaline were higher in right atria from mdx compared to C57 mice (P&lt;0.05), although in left atria only a greater efficacy was evident in mdx mice.	Carbachol	28-37	dystrophin, muscular dystrophy	Mus musculus	206-209
11129110-5	2000	In neurons a nonspecific muscarinic agonist, carbachol, reduced tau phosphorylation.	Carbachol	45-54	microtubule associated protein tau	Homo sapiens	64-67
10791841-1	2000	Carbachol, a muscarinic receptor agonist, produced three distinct spontaneous oscillations in the CA3 region of rat hippocampal slices.	Carbachol	0-9	carbonic anhydrase 3	Rattus norvegicus	98-101
10601308-4	1999	Co-expression of Ras-GRF1 with subtype 1 human muscarinic receptors in COS-7 cells allowed mapping of a carbachol-stimulated phosphorylation site to a region composed of residues 916-976.	Carbachol	104-113	Ras protein specific guanine nucleotide releasing factor 1	Homo sapiens	17-25
10791841-2	2000	Carbachol concentrations in the 4-13 microM range produced regular synchronized CA3 discharges at 0.5-2 Hz (carbachol-delta).	Carbachol	0-9	carbonic anhydrase 3	Rattus norvegicus	80-83
10791841-2	2000	Carbachol concentrations in the 4-13 microM range produced regular synchronized CA3 discharges at 0.5-2 Hz (carbachol-delta).	Carbachol	108-117	carbonic anhydrase 3	Rattus norvegicus	80-83
10791841-8	2000	Field and intracellular recordings from CA1 and CA3 pyramidal cells and interneurons during carbachol-induced rhythms revealed that the hippocampal circuitry preserved in the slice was capable of spontaneous activity over the range of frequencies observed in vivo and suggests that the presence of these rhythms could be under neuromodulatory control.	Carbachol	92-101	carbonic anhydrase 1	Rattus norvegicus	40-43
10791841-8	2000	Field and intracellular recordings from CA1 and CA3 pyramidal cells and interneurons during carbachol-induced rhythms revealed that the hippocampal circuitry preserved in the slice was capable of spontaneous activity over the range of frequencies observed in vivo and suggests that the presence of these rhythms could be under neuromodulatory control.	Carbachol	92-101	carbonic anhydrase 3	Rattus norvegicus	48-51
10794846-6	2000	In contrast to phosphoinositide hydrolysis, carbachol-stimulated AP-1 DNA binding activity was lower in Alzheimer"s disease than control cybrid cells, and this deficit was associated with deficient protein kinase C-mediated activation of AP-1.	Carbachol	44-53	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-69
10794846-6	2000	In contrast to phosphoinositide hydrolysis, carbachol-stimulated AP-1 DNA binding activity was lower in Alzheimer"s disease than control cybrid cells, and this deficit was associated with deficient protein kinase C-mediated activation of AP-1.	Carbachol	44-53	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	238-242
10622253-2	1999	The transactivation of epidermal growth factor receptor (EGFR)-dependent signalling pathways upon stimulation of G-protein-coupled receptors (GPCRs), which are critical for the mitogenic activity of ligands such as lysophosphatidic acid, endothelin, thrombin, bombesin and carbachol, provides evidence for such an interconnected communication network.	Carbachol	273-282	epidermal growth factor receptor	Homo sapiens	23-55
10622253-2	1999	The transactivation of epidermal growth factor receptor (EGFR)-dependent signalling pathways upon stimulation of G-protein-coupled receptors (GPCRs), which are critical for the mitogenic activity of ligands such as lysophosphatidic acid, endothelin, thrombin, bombesin and carbachol, provides evidence for such an interconnected communication network.	Carbachol	273-282	epidermal growth factor receptor	Homo sapiens	57-61
10622253-2	1999	The transactivation of epidermal growth factor receptor (EGFR)-dependent signalling pathways upon stimulation of G-protein-coupled receptors (GPCRs), which are critical for the mitogenic activity of ligands such as lysophosphatidic acid, endothelin, thrombin, bombesin and carbachol, provides evidence for such an interconnected communication network.	Carbachol	273-282	coagulation factor II, thrombin	Homo sapiens	250-258
10622253-2	1999	The transactivation of epidermal growth factor receptor (EGFR)-dependent signalling pathways upon stimulation of G-protein-coupled receptors (GPCRs), which are critical for the mitogenic activity of ligands such as lysophosphatidic acid, endothelin, thrombin, bombesin and carbachol, provides evidence for such an interconnected communication network.	Carbachol	273-282	gastrin releasing peptide	Homo sapiens	260-268
10601308-8	1999	Full-length Ras-GRF1 that contains an alanine 916 mutation was only partially activated by carbachol, suggesting that phosphorylation at residue 916 is necessary for full activation.	Carbachol	91-100	Ras protein specific guanine nucleotide releasing factor 1	Homo sapiens	12-20
10602325-2	1999	The dose-response parameters of recombinant mouse adult neuromuscular acetylcholine receptor channels (nAChR) activated by carbamylcholine, nicotine, muscarine and oxotremorine were measured.	Carbachol	123-138	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	103-108
10600935-7	1999	CO (100 nM) also suppressed NO release induced by 100 microM carbachol, a potent agonist for endothelial NOS (eNOS).	Carbachol	61-70	nitric oxide synthase 3	Rattus norvegicus	93-108
10559227-2	1999	The muscarinic agonist of chloride secretion, carbachol (CCh), also stimulates an antisecretory pathway that involves transactivation of the EGF receptor (EGFR) but does not involve PI3-K.	Carbachol	46-55	epidermal growth factor receptor	Homo sapiens	141-153
10586949-12	1999	ADM and CGRP inhibited carbachol-induced contraction in a concentration-dependent manner with IC50 values of 10 and 90 nM, respectively.	Carbachol	23-32	adrenomedullin	Homo sapiens	0-3
10586949-12	1999	ADM and CGRP inhibited carbachol-induced contraction in a concentration-dependent manner with IC50 values of 10 and 90 nM, respectively.	Carbachol	23-32	calcitonin related polypeptide alpha	Homo sapiens	8-12
10586950-7	1999	RESULTS: In tissues precontracted by carbachol PKC antagonist H7 led to a relaxation of TM (25+/-7.2 versus 100%; n = 8) with no effect on CM.	Carbachol	37-46	protein kinase C alpha	Bos taurus	47-50
10559227-2	1999	The muscarinic agonist of chloride secretion, carbachol (CCh), also stimulates an antisecretory pathway that involves transactivation of the EGF receptor (EGFR) but does not involve PI3-K.	Carbachol	46-55	epidermal growth factor receptor	Homo sapiens	155-159
10559227-2	1999	The muscarinic agonist of chloride secretion, carbachol (CCh), also stimulates an antisecretory pathway that involves transactivation of the EGF receptor (EGFR) but does not involve PI3-K.	Carbachol	57-60	epidermal growth factor receptor	Homo sapiens	141-153
10559227-2	1999	The muscarinic agonist of chloride secretion, carbachol (CCh), also stimulates an antisecretory pathway that involves transactivation of the EGF receptor (EGFR) but does not involve PI3-K.	Carbachol	57-60	epidermal growth factor receptor	Homo sapiens	155-159
10559227-3	1999	Here, we have examined if ErbB receptors, other than the EGFR, have a role in regulation of colonic secretion and if differential effects on ErbB receptor activation may explain the ability of the EGFR to propagate diverse signaling pathways in response to EGF versus CCh.	Carbachol	268-271	epidermal growth factor receptor	Homo sapiens	197-201
10559227-4	1999	Basolateral, but not apical, addition of the ErbB3/ErbB4 ligand alpha-heregulin (HRG; 1-100 ng/ml) inhibited secretory responses to CCh (100 microM) across voltage-clamped T(84) epithelial cells.	Carbachol	132-135	erb-b2 receptor tyrosine kinase 3	Homo sapiens	45-50
10559227-4	1999	Basolateral, but not apical, addition of the ErbB3/ErbB4 ligand alpha-heregulin (HRG; 1-100 ng/ml) inhibited secretory responses to CCh (100 microM) across voltage-clamped T(84) epithelial cells.	Carbachol	132-135	erb-b2 receptor tyrosine kinase 4	Homo sapiens	51-56
10559227-7	1999	Further studies revealed that, while both EGF (100 ng/ml) and CCh (100 microM) stimulated phosphorylation of the EGFR, only EGF stimulated phosphorylation of ErbB2, and neither stimulated ErbB3 phosphorylation.	Carbachol	62-65	epidermal growth factor receptor	Homo sapiens	113-117
10559227-7	1999	Further studies revealed that, while both EGF (100 ng/ml) and CCh (100 microM) stimulated phosphorylation of the EGFR, only EGF stimulated phosphorylation of ErbB2, and neither stimulated ErbB3 phosphorylation.	Carbachol	62-65	epidermal growth factor	Homo sapiens	113-116
10559227-7	1999	Further studies revealed that, while both EGF (100 ng/ml) and CCh (100 microM) stimulated phosphorylation of the EGFR, only EGF stimulated phosphorylation of ErbB2, and neither stimulated ErbB3 phosphorylation.	Carbachol	62-65	erb-b2 receptor tyrosine kinase 3	Homo sapiens	188-193
10559227-10	1999	Differential dimerization with other ErbB family members may underlie the ability of the EGFR to propagate diverse inhibitory signals in response to activation by EGF or transactivation by CCh.	Carbachol	189-192	epidermal growth factor receptor	Homo sapiens	37-41
10559227-10	1999	Differential dimerization with other ErbB family members may underlie the ability of the EGFR to propagate diverse inhibitory signals in response to activation by EGF or transactivation by CCh.	Carbachol	189-192	epidermal growth factor receptor	Homo sapiens	89-93
10559227-10	1999	Differential dimerization with other ErbB family members may underlie the ability of the EGFR to propagate diverse inhibitory signals in response to activation by EGF or transactivation by CCh.	Carbachol	189-192	epidermal growth factor	Homo sapiens	89-92
10514440-4	1999	Inhibition of protein kinase C with Ro31-8220, GF109203x, or Go6976 or down-regulation of protein kinase C inhibited increases in RGS2 mRNA levels induced by carbachol or by the activation of protein kinase C. Blockade of calcium signaling did not alter carbachol-induced increases in RGS2 mRNA levels.	Carbachol	158-167	regulator of G protein signaling 2	Homo sapiens	130-134
10561809-8	1999	Aortas also differed by a reduced ability to relax in response to carbamylcholine in hypertensive rats; this effect is hypertension (P &lt; 0.05) and group (P &lt; 0.005) dependent, without any change in carbamylcholine pD2 values.	Carbachol	66-81	neurogenin 3	Rattus norvegicus	45-50
10561809-8	1999	Aortas also differed by a reduced ability to relax in response to carbamylcholine in hypertensive rats; this effect is hypertension (P &lt; 0.05) and group (P &lt; 0.005) dependent, without any change in carbamylcholine pD2 values.	Carbachol	204-219	neurogenin 3	Rattus norvegicus	45-50
10585535-1	1999	In this study we investigated effects of acute and chronic ethanol exposure on carbachol-induced activator protein-1 (AP-1) DNA binding in rat cerebellar granule cells.	Carbachol	79-88	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-116
10585535-1	1999	In this study we investigated effects of acute and chronic ethanol exposure on carbachol-induced activator protein-1 (AP-1) DNA binding in rat cerebellar granule cells.	Carbachol	79-88	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	118-122
10585535-2	1999	Acute ethanol application did not alter, whereas chronic ethanol exposure potentiated the carbachol-induced AP-1 DNA binding.	Carbachol	90-99	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	108-112
10585535-3	1999	The protein composition of the AP-1 transcription factor complex activated by carbachol stimulation of muscarinic receptors was analysed in control and chronic ethanol-exposed cells using a supershift assay with specific antibodies against c-Fos, Fos B, c-Jun, Jun B and Jun D proteins.	Carbachol	78-87	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-35
10585535-4	1999	Supershift analysis revealed that the carbachol-induced AP-1 complex was composed predominantly of Jun D and c-Fos.	Carbachol	38-47	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-60
10585535-4	1999	Supershift analysis revealed that the carbachol-induced AP-1 complex was composed predominantly of Jun D and c-Fos.	Carbachol	38-47	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	99-104
10585535-4	1999	Supershift analysis revealed that the carbachol-induced AP-1 complex was composed predominantly of Jun D and c-Fos.	Carbachol	38-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-114
10585535-5	1999	The composition of the AP-1 complex activated by carbachol in chronic ethanol-exposed cells did not differ from control.	Carbachol	49-58	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-27
10585535-6	1999	These findings indicate that chronic ethanol treatment can modulate carbachol-induced AP-1 DNA binding activity in cerebellar granule cells.	Carbachol	68-77	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-90
10514440-2	1999	In human neuroblastoma SH-SY5Y cells stimulation of muscarinic receptors by carbachol activates phosphoinositide signaling and also caused a rapid, large, and long lasting increase in RGS2 mRNA levels.	Carbachol	76-85	regulator of G protein signaling 2	Homo sapiens	184-188
10506152-4	1999	The lack of NHE1, but not NHE2 or NHE3, prevented intracellular pH recovery from an acid load in resting acinar cells, in acini stimulated to secrete with the muscarinic agonist carbachol, and in acini shrunken by hypertonic addition of sucrose.	Carbachol	178-187	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	12-16
10571577-0	1999	Effect of carbachol on regulation of the mACh receptor mRNA expression ADN insulin secretion in mouse pancreatic islets.	Carbachol	10-19	complement factor D (adipsin)	Mus musculus	71-74
10519505-2	1999	METHODS: Protein tyrosine phosphorylation and ERK activation induced by carbachol, an agonist for muscarinic acetylcholine receptors, were examined in rat pheochromocytoma PC12 cells, a model for investigating signal transduction.	Carbachol	72-81	Eph receptor B1	Rattus norvegicus	46-49
10519505-3	1999	Carbachol-induced tyrosine-phosphorylated proteins of 44 and 42 kd were determined by Western blot analysis and identified as activated ERK1 and ERK2 using anti-ERK antibody.	Carbachol	0-9	mitogen activated protein kinase 3	Rattus norvegicus	136-140
10519505-3	1999	Carbachol-induced tyrosine-phosphorylated proteins of 44 and 42 kd were determined by Western blot analysis and identified as activated ERK1 and ERK2 using anti-ERK antibody.	Carbachol	0-9	mitogen activated protein kinase 1	Rattus norvegicus	145-149
10519505-3	1999	Carbachol-induced tyrosine-phosphorylated proteins of 44 and 42 kd were determined by Western blot analysis and identified as activated ERK1 and ERK2 using anti-ERK antibody.	Carbachol	0-9	Eph receptor B1	Rattus norvegicus	136-139
10519505-6	1999	The effects of three Na+ current-modifying reagents on carbachol-induced ERK activation were also evaluated.	Carbachol	55-64	Eph receptor B1	Rattus norvegicus	73-76
10519505-10	1999	The inhibition of carbachol-induced ERK activation by procaine was not modified by a phosphatase inhibitor, calyculin A.	Carbachol	18-27	Eph receptor B1	Rattus norvegicus	36-39
10493909-2	1999	Ca(2+) imaging was used to show caffeine-, carbachol- and thapsigargin-induced Ca(2+) release in HEK-293 cells transfected with ryanodine receptor (RyR) cDNA, but only carbachol- and thapsigargin-induced Ca(2+) release in untransfected HEK-293 cells.	Carbachol	43-52	ryanodine receptor 1	Homo sapiens	128-146
10493909-2	1999	Ca(2+) imaging was used to show caffeine-, carbachol- and thapsigargin-induced Ca(2+) release in HEK-293 cells transfected with ryanodine receptor (RyR) cDNA, but only carbachol- and thapsigargin-induced Ca(2+) release in untransfected HEK-293 cells.	Carbachol	43-52	ryanodine receptor 1	Homo sapiens	148-151
10493909-2	1999	Ca(2+) imaging was used to show caffeine-, carbachol- and thapsigargin-induced Ca(2+) release in HEK-293 cells transfected with ryanodine receptor (RyR) cDNA, but only carbachol- and thapsigargin-induced Ca(2+) release in untransfected HEK-293 cells.	Carbachol	168-177	ryanodine receptor 1	Homo sapiens	148-151
10529472-0	1999	Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.	Carbachol	14-23	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-39
10529472-3	1999	AP-1 activation stimulated by carbachol was reduced by pretreatment for 1 h, 24 h or 7 days with 1 mM lithium by 15%, 37%, and 60%, respectively, and with 0.05 mM carbamazepine by 3%, 21%, and 46%, respectively, but not by pretreatment with 0.5 mM sodium valproate.	Carbachol	30-39	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
10529472-4	1999	AP-1 DNA binding activity stimulated by carbachol or by phorbol ester-induced activation of protein kinase C was inhibited by the protein kinase C inhibitor Ro31-8220, but phorbol ester-stimulated AP-1 activation was unaltered by 7-day pretreatments with lithium or carbamazepine.	Carbachol	40-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
10529472-5	1999	Activation of AP-1 by carbachol was dependent on calcium, as it was inhibited by treatment with the extracellular calcium chelator EGTA, the intracellular calcium chelator BAPTA-AM, and the calcium/calmodulin kinase II inhibitor KN62.	Carbachol	22-31	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-18
10529472-7	1999	Thus, chronic treatment with the antibipolar agents lithium and carbamazepine attenuates carbachol-stimulated AP-1 DNA binding activity, and these agents preferentially inhibit signaling cascades activated by the calcium rather than the protein kinase C arm of the phosphoinositide signaling pathway.	Carbachol	89-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-114
10568524-0	1999	Induction of tyrosine hydroxylase and neuropeptide Y by carbachol: modulation with age.	Carbachol	56-65	neuropeptide Y	Rattus norvegicus	38-52
10501181-1	1999	Activation of muscarinic receptors in human neuroblastoma SH-SY5Y cells with carbachol stimulated a rapid and large increase in early growth response-1 (Egr-1, also called zif268 and NGF1-A) protein levels and DNA binding activity.	Carbachol	77-86	early growth response 1	Homo sapiens	128-151
10501181-1	1999	Activation of muscarinic receptors in human neuroblastoma SH-SY5Y cells with carbachol stimulated a rapid and large increase in early growth response-1 (Egr-1, also called zif268 and NGF1-A) protein levels and DNA binding activity.	Carbachol	77-86	early growth response 1	Homo sapiens	153-158
10501181-1	1999	Activation of muscarinic receptors in human neuroblastoma SH-SY5Y cells with carbachol stimulated a rapid and large increase in early growth response-1 (Egr-1, also called zif268 and NGF1-A) protein levels and DNA binding activity.	Carbachol	77-86	early growth response 1	Homo sapiens	172-178
10501181-2	1999	Egr-1 DNA binding activity was stimulated within 15 min of treatment with carbachol and maintained a maximum 20-fold increase over basal between 1 and 2 h after treatment, and the EC50 was approximately 1 microM carbachol.	Carbachol	74-83	early growth response 1	Homo sapiens	0-5
10501181-2	1999	Egr-1 DNA binding activity was stimulated within 15 min of treatment with carbachol and maintained a maximum 20-fold increase over basal between 1 and 2 h after treatment, and the EC50 was approximately 1 microM carbachol.	Carbachol	212-221	early growth response 1	Homo sapiens	0-5
10501181-3	1999	Carbachol-stimulated Egr-1 DNA binding activity was dependent on protein kinase C, as it was potently inhibited by GF109203X (IC50 approximately 0.1 microM) and was reduced by 85 +/- 5% by down-regulation of protein kinase C. Inhibitors of increases in intracellular calcium levels reduced carbachol-induced Egr-1 DNA binding activity by 25-35%.	Carbachol	0-9	early growth response 1	Homo sapiens	21-26
10501181-3	1999	Carbachol-stimulated Egr-1 DNA binding activity was dependent on protein kinase C, as it was potently inhibited by GF109203X (IC50 approximately 0.1 microM) and was reduced by 85 +/- 5% by down-regulation of protein kinase C. Inhibitors of increases in intracellular calcium levels reduced carbachol-induced Egr-1 DNA binding activity by 25-35%.	Carbachol	0-9	early growth response 1	Homo sapiens	308-313
10501181-3	1999	Carbachol-stimulated Egr-1 DNA binding activity was dependent on protein kinase C, as it was potently inhibited by GF109203X (IC50 approximately 0.1 microM) and was reduced by 85 +/- 5% by down-regulation of protein kinase C. Inhibitors of increases in intracellular calcium levels reduced carbachol-induced Egr-1 DNA binding activity by 25-35%.	Carbachol	290-299	early growth response 1	Homo sapiens	21-26
10501181-4	1999	Carbachol-stimulated activation of Egr-1 was reduced 35% by genistein, a tyrosine kinase inhibitor, and 60% by PD098059, an inhibitor of mitogen-activated protein kinase kinases 1/2 (MEK1/2) that activates extracellular-regulated kinases 1/2 (ERK1/2).	Carbachol	0-9	early growth response 1	Homo sapiens	35-40
10501181-4	1999	Carbachol-stimulated activation of Egr-1 was reduced 35% by genistein, a tyrosine kinase inhibitor, and 60% by PD098059, an inhibitor of mitogen-activated protein kinase kinases 1/2 (MEK1/2) that activates extracellular-regulated kinases 1/2 (ERK1/2).	Carbachol	0-9	mitogen-activated protein kinase kinase 1	Homo sapiens	137-181
10501181-4	1999	Carbachol-stimulated activation of Egr-1 was reduced 35% by genistein, a tyrosine kinase inhibitor, and 60% by PD098059, an inhibitor of mitogen-activated protein kinase kinases 1/2 (MEK1/2) that activates extracellular-regulated kinases 1/2 (ERK1/2).	Carbachol	0-9	mitogen-activated protein kinase kinase 1	Homo sapiens	183-189
10501181-4	1999	Carbachol-stimulated activation of Egr-1 was reduced 35% by genistein, a tyrosine kinase inhibitor, and 60% by PD098059, an inhibitor of mitogen-activated protein kinase kinases 1/2 (MEK1/2) that activates extracellular-regulated kinases 1/2 (ERK1/2).	Carbachol	0-9	mitogen-activated protein kinase 3	Homo sapiens	243-249
10501181-6	1999	Valproate treatment reduced carbachol-stimulated Egr-1 DNA binding activity by 60% but did not alter carbachol-induced activation of ERK1/2 or p38 or increases in Egr-1 protein levels.	Carbachol	28-37	early growth response 1	Homo sapiens	49-54
10501181-7	1999	These results reveal that muscarinic receptors activate Egr-1 through a signaling cascade primarily encompassing protein kinase C, MEK1/2, and ERK1/2 and that valproate substantially inhibits Egr-1 DNA binding activity stimulated by carbachol or protein kinase C.	Carbachol	233-242	early growth response 1	Homo sapiens	56-61
10501181-7	1999	These results reveal that muscarinic receptors activate Egr-1 through a signaling cascade primarily encompassing protein kinase C, MEK1/2, and ERK1/2 and that valproate substantially inhibits Egr-1 DNA binding activity stimulated by carbachol or protein kinase C.	Carbachol	233-242	early growth response 1	Homo sapiens	192-197
10514440-4	1999	Inhibition of protein kinase C with Ro31-8220, GF109203x, or Go6976 or down-regulation of protein kinase C inhibited increases in RGS2 mRNA levels induced by carbachol or by the activation of protein kinase C. Blockade of calcium signaling did not alter carbachol-induced increases in RGS2 mRNA levels.	Carbachol	254-263	regulator of G protein signaling 2	Homo sapiens	130-134
10461917-4	1999	Overexpression of G protein-coupled receptor kinase (GRK) 2 caused an increase in the rate constant for receptor endocytosis (from 0.06 to 0.18 min(-1)) and a decrease in the EC50 for carbachol stimulation of internalization (from 15 to 3 microM).	Carbachol	184-193	G protein-coupled receptor kinase 2	Mus musculus	18-59
10484474-3	1999	Carbachol-, lysophosphatidic acid (LPA)-, and endothelin-1-induced increases in filamentous actin staining are indicative of actin reorganization (filamentous-to-globular actin ratios of 2.4 +/- 0.3 in control cells, 6.7 +/- 0.8 with carbachol, 7.2 +/- 0.8 with LPA, and 7.4 +/- 0.9 with endothelin-1; P &lt; 0.001; n = 14 experiments).	Carbachol	0-9	endothelin 1	Homo sapiens	288-300
10484474-3	1999	Carbachol-, lysophosphatidic acid (LPA)-, and endothelin-1-induced increases in filamentous actin staining are indicative of actin reorganization (filamentous-to-globular actin ratios of 2.4 +/- 0.3 in control cells, 6.7 +/- 0.8 with carbachol, 7.2 +/- 0.8 with LPA, and 7.4 +/- 0.9 with endothelin-1; P &lt; 0.001; n = 14 experiments).	Carbachol	234-243	endothelin 1	Homo sapiens	46-58
10484474-5	1999	Although carbachol-induced actin reorganization was blocked in cells pretreated with antisense oligonucleotides directed against Galphai-2 alone, LPA- and endothelin-1-induced actin reorganization were only blocked when both Galphai-2 and G(q)alpha were depleted.	Carbachol	9-18	endothelin 1	Homo sapiens	155-167
10519135-9	1999	In human colonocytes (T84) exposed to hSK4 antisense probes, but not to sense probes, carbachol-induced K+ currents were attenuated.	Carbachol	86-95	potassium calcium-activated channel subfamily N member 4	Homo sapiens	38-42
10404113-1	1999	We used immunocytochemistry to determine the regional and temporal distribution of Fos protein expression in awake and unrestrained rats after a unilateral stereotaxic microinjection of a cholinergic agonist, carbachol, in the thalamic ventroposterolateral and reticular nuclei, previously shown to cause limbic and generalized convulsive seizures.	Carbachol	209-218	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-86
10404113-2	1999	The microinjection of carbachol elicits behavioral alterations including immobilization, staring, facial and jaw clonus, rearing, and falling, followed by recurrent generalized convulsive seizures, and a pattern of c-fos expression throughout the brain.	Carbachol	22-31	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	215-220
10404113-3	1999	In addition to the hypothalamic paraventricular and supraoptic nuclei, the initial induction of c-fos expression was observed as early as 15 minutes after the carbachol microinjection, in the piriform and entorhinal cortices, the thalamic paraventricular, the supramammilary, the lateral parabrachial nuclei, and the central gray.	Carbachol	159-168	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-101
10441519-6	1999	Carbachol also induced degradation of IkappaBalpha, which was reversed by addition of both GF109203X and PDTC and stimulated the activity of a NF-kappaB-luciferase reporter gene plasmid in COS-7 cells stably expressing the human M3 muscarinic receptor.	Carbachol	0-9	cholinergic receptor muscarinic 3	Homo sapiens	229-251
10423442-7	1999	After treatment with carbachol, which stimulates contraction and PKC activity, in addition to the membrane localization, the activated PKC exhibited a pronounced cytosolic fibrillar distribution and an increased total fluorescence intensity relative to vinculin.	Carbachol	21-30	proline rich transmembrane protein 2	Homo sapiens	65-68
10423442-7	1999	After treatment with carbachol, which stimulates contraction and PKC activity, in addition to the membrane localization, the activated PKC exhibited a pronounced cytosolic fibrillar distribution and an increased total fluorescence intensity relative to vinculin.	Carbachol	21-30	proline rich transmembrane protein 2	Homo sapiens	135-138
10423442-7	1999	After treatment with carbachol, which stimulates contraction and PKC activity, in addition to the membrane localization, the activated PKC exhibited a pronounced cytosolic fibrillar distribution and an increased total fluorescence intensity relative to vinculin.	Carbachol	21-30	vinculin	Homo sapiens	253-261
10461917-5	1999	Overexpression of a dominant negative form of GRK2 had more modest effects, reducing the rate constant for endocytosis (from 0.11 to 0.07 min(-1)) and increasing the EC50 for carbachol stimulation of internalization (from 8 to 17 microM).	Carbachol	175-184	G protein-coupled receptor kinase 2	Mus musculus	46-50
10362652-13	1999	We then investigated the role of betagamma-subunits in carbachol induction of HA-ERK2.	Carbachol	55-64	mitogen-activated protein kinase 1	Canis lupus familiaris	78-85
10419481-8	1999	Investigating the cell cycle mechanisms involved in growth inhibition, we found that carbachol treatment decreased cyclin D1 levels, increased p21(cip1) expression, and led to hypophosphorylation of the retinoblastoma gene product (Rb).	Carbachol	85-94	cyclin D1	Mus musculus	115-124
10448929-0	1999	Involvement of calmodulin and protein kinase C in the regulation of K+ transport by carbachol across the rat distal colon.	Carbachol	84-93	calmodulin 1	Rattus norvegicus	15-25
10448929-4	1999	The Ca2+-calmodulin antagonist calmidazolium (10(-7) mol l(-1)) inhibited the stimulation of mucosal and serosal Rb+ efflux by carbachol.	Carbachol	127-136	calmodulin 1	Rattus norvegicus	9-19
10448929-8	1999	Both calmidazolium and staurosporine, but not KN-62, prevented the stimulatory action of carbachol on the H+-K+-ATPase, suggesting a synergistic control of this ion pump by both Ca2+-calmodulin and protein kinase C.	Carbachol	89-98	calmodulin 1	Rattus norvegicus	183-193
10409227-5	1999	With the use of intact human bronchial rings, alpha-thrombin (1-20 U/ml) increased bronchial tone to 19 +/- 3% of basal tone (P = 0.008; n = 5 experiments) and represents 20 +/- 8% of the maximum carbachol response.	Carbachol	196-205	coagulation factor II, thrombin	Homo sapiens	52-60
10419481-8	1999	Investigating the cell cycle mechanisms involved in growth inhibition, we found that carbachol treatment decreased cyclin D1 levels, increased p21(cip1) expression, and led to hypophosphorylation of the retinoblastoma gene product (Rb).	Carbachol	85-94	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	143-146
10419481-8	1999	Investigating the cell cycle mechanisms involved in growth inhibition, we found that carbachol treatment decreased cyclin D1 levels, increased p21(cip1) expression, and led to hypophosphorylation of the retinoblastoma gene product (Rb).	Carbachol	85-94	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	147-151
10419481-9	1999	Proteasome inhibitors blocked the carbachol-induced degradation of cyclin D1.	Carbachol	34-43	cyclin D1	Mus musculus	67-76
10362652-0	1999	Carbachol activates ERK2 in isolated gastric parietal cells via multiple signaling pathways.	Carbachol	0-9	mitogen-activated protein kinase 1	Canis lupus familiaris	20-24
10362652-1	1999	We previously reported that both carbachol and epidermal growth factor (EGF) are potent inducers of the extracellular signal-regulated protein kinases (ERKs) in isolated gastric canine parietal cells and that induction of these kinases leads to acute inhibitory and chronic stimulatory effects on gastric acid secretion.	Carbachol	33-42	mitogen-activated protein kinase 1	Canis lupus familiaris	152-156
10362652-6	1999	Dominant negative Ras reduced carbachol induction of HA-ERK2 activity by 60% and completely inhibited the stimulatory effect of EGF.	Carbachol	30-39	mitogen-activated protein kinase 1	Canis lupus familiaris	53-60
10362652-15	1999	In the presence of this vector, carbachol induction of HA-ERK2 was inhibited by 40%.	Carbachol	32-41	mitogen-activated protein kinase 1	Canis lupus familiaris	55-62
10362652-16	1999	Together these data suggest that, in the gastric parietal cells, carbachol activates the ERKs through Ras- and betagamma-dependent mechanisms that require guanine nucleotide exchange factors other than Sos.	Carbachol	65-74	mitogen-activated protein kinase 1	Canis lupus familiaris	89-93
10417666-4	1999	Carbachol (CCh, 10 micromol/l ) induced a 335+/-10 nmol/l (n=8) rise in [Ca2+ ]i in control myotubes and 531.9+/-32 nmol/l (n=23) in LGMD2C myotubes.	Carbachol	0-9	sarcoglycan gamma	Homo sapiens	133-139
10417666-4	1999	Carbachol (CCh, 10 micromol/l ) induced a 335+/-10 nmol/l (n=8) rise in [Ca2+ ]i in control myotubes and 531.9+/-32 nmol/l (n=23) in LGMD2C myotubes.	Carbachol	11-14	sarcoglycan gamma	Homo sapiens	133-139
10234035-1	1999	Although it has long been known that microinjection of the cholinergic agonist carbachol into the medial pontine reticular formation (mPRF) induces a state that resembles rapid eye movement (REM) sleep, it is likely that other transmitters contribute to mPRF regulation of behavioral states.	Carbachol	79-88	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	134-138
10234035-1	1999	Although it has long been known that microinjection of the cholinergic agonist carbachol into the medial pontine reticular formation (mPRF) induces a state that resembles rapid eye movement (REM) sleep, it is likely that other transmitters contribute to mPRF regulation of behavioral states.	Carbachol	79-88	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	254-258
10331408-4	1999	Adenovirus-mediated overexpression of PLC-delta1, -beta1, or -beta3 in INS-1 or betaG 40/110 cells results in little or no enhancement in inositol phosphate (IP) accumulation and no improvement in insulin secretion when the cells are stimulated with glucose or carbachol, despite the fact that the overexpressed proteins are fully active in cell extracts.	Carbachol	261-270	phospholipase C, delta 1	Rattus norvegicus	38-67
10579054-4	1999	Application of the cholinergic agonist carbamylcholine (100 microM) to transfected S2-DM1 cells expressing a Drosophila muscarinic acetylcholine receptor (DM1) emptied the InsP3-sensitive Ca2+ store but failed to affect the amplitude of alkalinization-evoked Ca2+ release.	Carbachol	39-54	muscarinic Acetylcholine Receptor, A-type	Drosophila melanogaster	86-89
10579054-4	1999	Application of the cholinergic agonist carbamylcholine (100 microM) to transfected S2-DM1 cells expressing a Drosophila muscarinic acetylcholine receptor (DM1) emptied the InsP3-sensitive Ca2+ store but failed to affect the amplitude of alkalinization-evoked Ca2+ release.	Carbachol	39-54	muscarinic Acetylcholine Receptor, A-type	Drosophila melanogaster	120-153
10579054-4	1999	Application of the cholinergic agonist carbamylcholine (100 microM) to transfected S2-DM1 cells expressing a Drosophila muscarinic acetylcholine receptor (DM1) emptied the InsP3-sensitive Ca2+ store but failed to affect the amplitude of alkalinization-evoked Ca2+ release.	Carbachol	39-54	muscarinic Acetylcholine Receptor, A-type	Drosophila melanogaster	155-158
10579054-4	1999	Application of the cholinergic agonist carbamylcholine (100 microM) to transfected S2-DM1 cells expressing a Drosophila muscarinic acetylcholine receptor (DM1) emptied the InsP3-sensitive Ca2+ store but failed to affect the amplitude of alkalinization-evoked Ca2+ release.	Carbachol	39-54	Inositol 1,4,5,-trisphosphate receptor	Drosophila melanogaster	172-177
10436402-3	1999	To study the role of NO in mediating the effect of carbachol on Na-HCO(3) cotransporter, we measured the activity of the cotransporter in rabbit proximal tubule cells treated with carbachol (10(-4 )M) or the NO inhibitor, L-NAME (10(-3) M), or carbachol+L-NAME.	Carbachol	51-60	electrogenic sodium bicarbonate cotransporter 1	Oryctolagus cuniculus	64-87
10215681-4	1999	SLPI also inhibited the development of airway hyperresponsiveness to carbachol (84%, p &lt;.	Carbachol	69-78	antileukoproteinase	Ovis aries	0-4
10352035-20	1999	We conclude that the differences between CCh- and CCK-induced calcium oscillations in pancreatic acinar cells can be explained by two principal mechanisms: (a) CCK causes more phosphorylation of the IP3 receptor than does CCh, and the phosphorylated receptor cannot pass calcium current; and (b) the rate of calcium ATPase pumping and the rate of calcium influx from the outside the cell are greater in the presence of CCh than in the presence of CCK.	Carbachol	41-44	cholecystokinin	Homo sapiens	160-163
10352035-20	1999	We conclude that the differences between CCh- and CCK-induced calcium oscillations in pancreatic acinar cells can be explained by two principal mechanisms: (a) CCK causes more phosphorylation of the IP3 receptor than does CCh, and the phosphorylated receptor cannot pass calcium current; and (b) the rate of calcium ATPase pumping and the rate of calcium influx from the outside the cell are greater in the presence of CCh than in the presence of CCK.	Carbachol	41-44	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	199-211
10352035-20	1999	We conclude that the differences between CCh- and CCK-induced calcium oscillations in pancreatic acinar cells can be explained by two principal mechanisms: (a) CCK causes more phosphorylation of the IP3 receptor than does CCh, and the phosphorylated receptor cannot pass calcium current; and (b) the rate of calcium ATPase pumping and the rate of calcium influx from the outside the cell are greater in the presence of CCh than in the presence of CCK.	Carbachol	41-44	cholecystokinin	Homo sapiens	160-163
10352035-20	1999	We conclude that the differences between CCh- and CCK-induced calcium oscillations in pancreatic acinar cells can be explained by two principal mechanisms: (a) CCK causes more phosphorylation of the IP3 receptor than does CCh, and the phosphorylated receptor cannot pass calcium current; and (b) the rate of calcium ATPase pumping and the rate of calcium influx from the outside the cell are greater in the presence of CCh than in the presence of CCK.	Carbachol	222-225	cholecystokinin	Homo sapiens	50-53
10352035-20	1999	We conclude that the differences between CCh- and CCK-induced calcium oscillations in pancreatic acinar cells can be explained by two principal mechanisms: (a) CCK causes more phosphorylation of the IP3 receptor than does CCh, and the phosphorylated receptor cannot pass calcium current; and (b) the rate of calcium ATPase pumping and the rate of calcium influx from the outside the cell are greater in the presence of CCh than in the presence of CCK.	Carbachol	222-225	cholecystokinin	Homo sapiens	50-53
10200428-5	1999	Recombinant prenylated Rnd1 (0.01-0.1 mg ml-1) dose dependently inhibited carbachol- and GTPgammaS-induced Ca2+ sensitization in beta-escin-permeabilized ileal smooth muscle strips but had no effect on the tension at submaximal [Ca2+] (pCa 6.3).	Carbachol	74-83	Rho family GTPase 1	Rattus norvegicus	23-27
10213914-8	1999	The cholinergic agonist carbachol (CAR) (10(-7) M) also released CRH and this action was blocked by ATR (10(-7) M).	Carbachol	24-33	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	35-38
10213914-8	1999	The cholinergic agonist carbachol (CAR) (10(-7) M) also released CRH and this action was blocked by ATR (10(-7) M).	Carbachol	24-33	corticotropin releasing hormone	Rattus norvegicus	65-68
10213914-8	1999	The cholinergic agonist carbachol (CAR) (10(-7) M) also released CRH and this action was blocked by ATR (10(-7) M).	Carbachol	24-33	ATR serine/threonine kinase	Rattus norvegicus	100-103
10411313-1	1999	Pituitary adenylyl cyclase activating polypeptide (PACAP-27), forskoline and carbachol increased type A atrial natriuretic peptide receptor (NPR-A) density, as well as NPR-A mRNA level, in the human neuroblastoma NB-OK-1 cell line.	Carbachol	77-86	natriuretic peptide receptor 1	Homo sapiens	141-146
10411313-1	1999	Pituitary adenylyl cyclase activating polypeptide (PACAP-27), forskoline and carbachol increased type A atrial natriuretic peptide receptor (NPR-A) density, as well as NPR-A mRNA level, in the human neuroblastoma NB-OK-1 cell line.	Carbachol	77-86	natriuretic peptide receptor 1	Homo sapiens	168-173
10411313-4	1999	Our data support an original transcriptional upregulation of human NPR-A in response to cAMP-induced agents, and in response to carbachol.	Carbachol	128-137	natriuretic peptide receptor 1	Homo sapiens	67-72
10101239-0	1999	Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine.	Carbachol	103-112	brain derived neurotrophic factor	Homo sapiens	12-24
10436402-5	1999	In control cells, carbachol significantly increased Na-HCO(3) cotransporter activity while L-NAME did not affect the activity of the cotransporter but completely blocked the enhancement induced by carbachol.	Carbachol	18-27	solute carrier family 4 member 4	Homo sapiens	52-75
10101239-8	1999	Nicotine and carbachol caused transient decreases in NT-3 mRNA levels in dentate gyrus and CA2 with pilocarpine showing a similar trend.	Carbachol	13-22	carbonic anhydrase 2	Homo sapiens	91-94
10187833-5	1999	In these studies we confirmed that H7, but not HA1004, potently blocks the induction of zif268 and c-fos mRNA by nerve growth factor, carbachol, phorbol ester, Ca2+ ionophore, or forskolin.	Carbachol	134-143	early growth response 1	Rattus norvegicus	88-94
10187833-5	1999	In these studies we confirmed that H7, but not HA1004, potently blocks the induction of zif268 and c-fos mRNA by nerve growth factor, carbachol, phorbol ester, Ca2+ ionophore, or forskolin.	Carbachol	134-143	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	99-104
10101239-0	1999	Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine.	Carbachol	103-112	neurotrophic receptor tyrosine kinase 1	Homo sapiens	29-32
10101239-6	1999	In contrast, carbachol and pilocarpine produced a transient increase in NGF mRNA levels present 4-8 h after drug administration.	Carbachol	13-22	nerve growth factor	Homo sapiens	72-75
9989779-8	1999	Moreover, the muscarinic agonist carbachol was found to inhibit MELC differentiation by decreasing by approximately 35% the amount of benzidine-positive (B+) cells in HMBA-induced cultures and, to a lesser degree, also AChE levels.	Carbachol	33-42	acetylcholinesterase	Mus musculus	219-223
10209246-5	1999	To test the hypothesis that activation of mAchR also increases phosphorylation of B-50, protein phosphorylation has been examined in cerebral cortical slices in response to the cholinergic agonist, carbachol (Cch) in comparison to the phorbol ester, 4beta-phorbol 12, 13-dibutyrate (PDB), a known activator of PKC.	Carbachol	198-207	growth associated protein 43	Homo sapiens	82-86
10209246-6	1999	At short times of incubation with 1 mM Cch, a concentration which maximally activates PI metabolism, increased phosphorylation of a group of synaptosomal proteins, including B-50 and myristoylated, alanine-rich C kinase substrate (MARCKS), was observed.	Carbachol	39-42	growth associated protein 43	Homo sapiens	174-229
10209246-6	1999	At short times of incubation with 1 mM Cch, a concentration which maximally activates PI metabolism, increased phosphorylation of a group of synaptosomal proteins, including B-50 and myristoylated, alanine-rich C kinase substrate (MARCKS), was observed.	Carbachol	39-42	myristoylated alanine rich protein kinase C substrate	Homo sapiens	231-237
10209246-9	1999	Phosphorylation of B-50 and MARCKS was sensitive to Cch in both cases.	Carbachol	52-55	growth associated protein 43	Homo sapiens	19-23
10209246-9	1999	Phosphorylation of B-50 and MARCKS was sensitive to Cch in both cases.	Carbachol	52-55	myristoylated alanine rich protein kinase C substrate	Homo sapiens	28-34
10198350-3	1999	Secretin also elicited relaxation of carbachol-stimulated rat forestomach muscle strips by binding to its receptors, suggesting a direct action on this peripheral tissue.	Carbachol	37-46	secretin	Rattus norvegicus	0-8
10323594-6	1999	In binding assays none of the compounds studied displayed preferential affinity for the M1,3,4 or M5 subtypes although carbachol was less potent at hM1 than hM3,4,5.	Carbachol	119-128	cholinergic receptor muscarinic 1	Homo sapiens	148-151
10103113-3	1999	We report that in rat hippocampal neuronal cultures, GP120 induces a dramatic and persistent increase in [Ca2+]i which is prevented by drugs that either deplete (caffeine, carbachol, thapsigargin) or block (dantrolene) Ca2+ release from intracellular stores.	Carbachol	172-181	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
10103124-5	1999	Responses induced by NMDA, carbachol or both agonists on microdiscs were reduced by phospholipase A2 inhibitors, the most striking effects being observed with mepacrine.	Carbachol	27-36	phospholipase A2, group IB, pancreas	Mus musculus	84-100
10203138-6	1999	However, Cftr-/- pancreatic acini showed a significantly greater amylase response to the combination of BrcAMP and carbachol than the sum of the individual responses in separate experiments (p &lt; 0.05).	Carbachol	115-124	cystic fibrosis transmembrane conductance regulator	Mus musculus	9-13
10203138-10	1999	However, Cftr-/- pancreatic acini exhibited a synergistic secretory response following stimulation by BrcAMP plus carbachol.	Carbachol	114-123	cystic fibrosis transmembrane conductance regulator	Mus musculus	9-13
10070131-4	1999	Jejunal segments from anti-CD3-treated mice displayed a significantly elevated epithelial baseline short-circuit current (which indicates increased ion transport) and a concomitant reduction in responsiveness to prosecretory stimuli (nerve stimulation, carbachol, and forskolin).	Carbachol	253-262	CD3 antigen, epsilon polypeptide	Mus musculus	27-30
10198335-4	1999	CCK (10 pM-10 nM) and carbachol (0.1-100 microM) dose dependently increased the amount of immunodetectable RhoA with a peak increase occurring at 3 min.	Carbachol	22-31	ras homolog family member A	Rattus norvegicus	107-111
10198335-6	1999	Although an increase in RhoA did not require the presence of extracellular Ca2+, the intracellular Ca2+ chelator 1, 2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-AM abolished the appearance of the RhoA band in response to CCK and carbachol.	Carbachol	239-248	ras homolog family member A	Rattus norvegicus	24-28
10198335-13	1999	We concluded that the small GTP-binding protein RhoA p21 exists in pancreatic acini and appears to be involved in the mediation of pancreatic enzyme secretion evoked by CCK and carbachol.	Carbachol	177-186	ras homolog family member A	Rattus norvegicus	48-52
10198335-13	1999	We concluded that the small GTP-binding protein RhoA p21 exists in pancreatic acini and appears to be involved in the mediation of pancreatic enzyme secretion evoked by CCK and carbachol.	Carbachol	177-186	KRAS proto-oncogene, GTPase	Rattus norvegicus	53-56
10198354-4	1999	Carbachol and endothelin-1 increased GTP-bound p21(ras) in a pertussis toxin-sensitive manner [ratio of [32P]GTP to ([32P]GTP + [32P]GDP): control, 30 +/- 1.7; 3 min of 1 microM carbachol, 39 +/- 1.1; 3 min of 1 microM endothelin-1, 40 +/- 1.2], whereas histamine, bradykinin, and KCl were without effect.	Carbachol	0-9	H3 histone pseudogene 16	Homo sapiens	47-50
10198354-4	1999	Carbachol and endothelin-1 increased GTP-bound p21(ras) in a pertussis toxin-sensitive manner [ratio of [32P]GTP to ([32P]GTP + [32P]GDP): control, 30 +/- 1.7; 3 min of 1 microM carbachol, 39 +/- 1.1; 3 min of 1 microM endothelin-1, 40 +/- 1.2], whereas histamine, bradykinin, and KCl were without effect.	Carbachol	0-9	endothelin 1	Homo sapiens	219-231
10198354-4	1999	Carbachol and endothelin-1 increased GTP-bound p21(ras) in a pertussis toxin-sensitive manner [ratio of [32P]GTP to ([32P]GTP + [32P]GDP): control, 30 +/- 1.7; 3 min of 1 microM carbachol, 39 +/- 1.1; 3 min of 1 microM endothelin-1, 40 +/- 1.2], whereas histamine, bradykinin, and KCl were without effect.	Carbachol	0-9	kininogen 1	Homo sapiens	265-275
10198354-4	1999	Carbachol and endothelin-1 increased GTP-bound p21(ras) in a pertussis toxin-sensitive manner [ratio of [32P]GTP to ([32P]GTP + [32P]GDP): control, 30 +/- 1.7; 3 min of 1 microM carbachol, 39 +/- 1.1; 3 min of 1 microM endothelin-1, 40 +/- 1.2], whereas histamine, bradykinin, and KCl were without effect.	Carbachol	178-187	endothelin 1	Homo sapiens	14-26
10198354-4	1999	Carbachol and endothelin-1 increased GTP-bound p21(ras) in a pertussis toxin-sensitive manner [ratio of [32P]GTP to ([32P]GTP + [32P]GDP): control, 30 +/- 1.7; 3 min of 1 microM carbachol, 39 +/- 1.1; 3 min of 1 microM endothelin-1, 40 +/- 1.2], whereas histamine, bradykinin, and KCl were without effect.	Carbachol	178-187	H3 histone pseudogene 16	Homo sapiens	47-50
10203138-4	1999	Carbachol and BrcAMP or BrcAMP and forskolin, given in combination, produced additive effects on enzyme secretion in the Cftr+/+ acini.	Carbachol	0-9	cystic fibrosis transmembrane conductance regulator	Mus musculus	121-125
10066893-7	1999	Carbachol (CCh, 1-30 microM) increased the inwardly rectifying current in 70 % of GIRK1+ GIRK2-transfected cells by 261 +/- 53 % (n = 6, CCh 30 microM) at -120 mV, but had no effect in non-transfected cells or in cells transfected with GIRK1 or GIRK2 alone.	Carbachol	0-9	potassium inwardly-rectifying channel, subfamily J, member 3	Rattus norvegicus	82-87
10066893-7	1999	Carbachol (CCh, 1-30 microM) increased the inwardly rectifying current in 70 % of GIRK1+ GIRK2-transfected cells by 261 +/- 53 % (n = 6, CCh 30 microM) at -120 mV, but had no effect in non-transfected cells or in cells transfected with GIRK1 or GIRK2 alone.	Carbachol	0-9	potassium inwardly-rectifying channel, subfamily J, member 6	Rattus norvegicus	89-94
10066893-7	1999	Carbachol (CCh, 1-30 microM) increased the inwardly rectifying current in 70 % of GIRK1+ GIRK2-transfected cells by 261 +/- 53 % (n = 6, CCh 30 microM) at -120 mV, but had no effect in non-transfected cells or in cells transfected with GIRK1 or GIRK2 alone.	Carbachol	0-9	potassium inwardly-rectifying channel, subfamily J, member 3	Rattus norvegicus	236-241
10066893-7	1999	Carbachol (CCh, 1-30 microM) increased the inwardly rectifying current in 70 % of GIRK1+ GIRK2-transfected cells by 261 +/- 53 % (n = 6, CCh 30 microM) at -120 mV, but had no effect in non-transfected cells or in cells transfected with GIRK1 or GIRK2 alone.	Carbachol	0-9	potassium inwardly-rectifying channel, subfamily J, member 6	Rattus norvegicus	245-250
10066893-7	1999	Carbachol (CCh, 1-30 microM) increased the inwardly rectifying current in 70 % of GIRK1+ GIRK2-transfected cells by 261 +/- 53 % (n = 6, CCh 30 microM) at -120 mV, but had no effect in non-transfected cells or in cells transfected with GIRK1 or GIRK2 alone.	Carbachol	11-14	potassium inwardly-rectifying channel, subfamily J, member 3	Rattus norvegicus	82-87
10066893-7	1999	Carbachol (CCh, 1-30 microM) increased the inwardly rectifying current in 70 % of GIRK1+ GIRK2-transfected cells by 261 +/- 53 % (n = 6, CCh 30 microM) at -120 mV, but had no effect in non-transfected cells or in cells transfected with GIRK1 or GIRK2 alone.	Carbachol	11-14	potassium inwardly-rectifying channel, subfamily J, member 6	Rattus norvegicus	89-94
10066893-7	1999	Carbachol (CCh, 1-30 microM) increased the inwardly rectifying current in 70 % of GIRK1+ GIRK2-transfected cells by 261 +/- 53 % (n = 6, CCh 30 microM) at -120 mV, but had no effect in non-transfected cells or in cells transfected with GIRK1 or GIRK2 alone.	Carbachol	11-14	potassium inwardly-rectifying channel, subfamily J, member 3	Rattus norvegicus	236-241
10066893-7	1999	Carbachol (CCh, 1-30 microM) increased the inwardly rectifying current in 70 % of GIRK1+ GIRK2-transfected cells by 261 +/- 53 % (n = 6, CCh 30 microM) at -120 mV, but had no effect in non-transfected cells or in cells transfected with GIRK1 or GIRK2 alone.	Carbachol	11-14	potassium inwardly-rectifying channel, subfamily J, member 6	Rattus norvegicus	245-250
10070103-5	1999	TNF-alpha treatment for 72 h significantly increased the expression of Galphai-2 and Gqalpha proteins and enhanced carbachol (10(-7) M)-mediated inhibition of adenylyl cyclase activity and inositol phosphate synthesis.	Carbachol	115-124	tumor necrosis factor	Homo sapiens	0-9
9989779-9	1999	The carbachol effect on erythroid differentiation was reverted by atropine that was found to restore the original amount of B+ cells, while it reduced acetylcholinesterase (AChE) to levels of approximately 66% of control.	Carbachol	4-13	acetylcholinesterase	Mus musculus	151-171
9989779-9	1999	The carbachol effect on erythroid differentiation was reverted by atropine that was found to restore the original amount of B+ cells, while it reduced acetylcholinesterase (AChE) to levels of approximately 66% of control.	Carbachol	4-13	acetylcholinesterase	Mus musculus	173-177
10208302-7	1999	Linear Schild plots with slopes near to unity indicated that [F/G]NC(1-13)NH2 is a competitive antagonist, specific for NC receptors both in vitro (since it was inactive on opioid receptors) and in vivo (since it was inactive against carbachol).	Carbachol	234-243	prepronociceptin	Rattus norvegicus	66-68
10049786-3	1999	Activation of muscarinic receptors with carbachol was found to inhibit EGF-induced signaling, including tyrosine phosphorylation of the adaptor protein Cbl and of the EGF receptor, and complex formation between Shc proteins and the EGF receptor and Grb2.	Carbachol	40-49	epidermal growth factor	Homo sapiens	71-74
10049786-3	1999	Activation of muscarinic receptors with carbachol was found to inhibit EGF-induced signaling, including tyrosine phosphorylation of the adaptor protein Cbl and of the EGF receptor, and complex formation between Shc proteins and the EGF receptor and Grb2.	Carbachol	40-49	Cbl proto-oncogene	Homo sapiens	152-155
10049786-3	1999	Activation of muscarinic receptors with carbachol was found to inhibit EGF-induced signaling, including tyrosine phosphorylation of the adaptor protein Cbl and of the EGF receptor, and complex formation between Shc proteins and the EGF receptor and Grb2.	Carbachol	40-49	epidermal growth factor receptor	Homo sapiens	167-179
10049786-3	1999	Activation of muscarinic receptors with carbachol was found to inhibit EGF-induced signaling, including tyrosine phosphorylation of the adaptor protein Cbl and of the EGF receptor, and complex formation between Shc proteins and the EGF receptor and Grb2.	Carbachol	40-49	epidermal growth factor receptor	Homo sapiens	232-244
10049786-3	1999	Activation of muscarinic receptors with carbachol was found to inhibit EGF-induced signaling, including tyrosine phosphorylation of the adaptor protein Cbl and of the EGF receptor, and complex formation between Shc proteins and the EGF receptor and Grb2.	Carbachol	40-49	growth factor receptor bound protein 2	Homo sapiens	249-253
10208302-7	1999	Linear Schild plots with slopes near to unity indicated that [F/G]NC(1-13)NH2 is a competitive antagonist, specific for NC receptors both in vitro (since it was inactive on opioid receptors) and in vivo (since it was inactive against carbachol).	Carbachol	234-243	prepronociceptin	Rattus norvegicus	120-122
9920901-6	1999	The response of mouse pancreatic acini to carbachol was about 4- and 33-fold more sensitive to RGS4 than that of bombesin and cholecystokinin (CCK), respectively.	Carbachol	42-51	regulator of G-protein signaling 4	Mus musculus	95-99
10081931-3	1999	These Ca2+-responses were augmented by +70% by focally applied carbachol.	Carbachol	63-72	carbonic anhydrase 2	Rattus norvegicus	6-9
10048785-3	1999	Thus, ANP (1 microM) increased cGMP production in the SV-CISM-2 cells and CISM cells by 487- and 1.7-fold, respectively, and inhibited CCh-induced [Ca2+]i mobilisation by 95 and 3%, respectively.	Carbachol	135-138	natriuretic peptide A	Homo sapiens	6-9
10048785-4	1999	In the SV-CISM-2 cells, ANP and CNP dose dependently inhibited CCh-induced [Ca2+]i mobilisation with IC50 values of 156 and 412 nM, respectively, and dose dependently stimulated cGMP formation with EC50 values of 24 and 88 nM, respectively, suggesting that the inhibitory actions of the peptides are mediated through cGMP.	Carbachol	63-66	natriuretic peptide A	Homo sapiens	24-27
10048785-4	1999	In the SV-CISM-2 cells, ANP and CNP dose dependently inhibited CCh-induced [Ca2+]i mobilisation with IC50 values of 156 and 412 nM, respectively, and dose dependently stimulated cGMP formation with EC50 values of 24 and 88 nM, respectively, suggesting that the inhibitory actions of the peptides are mediated through cGMP.	Carbachol	63-66	natriuretic peptide C	Homo sapiens	32-35
10348664-5	1999	That carbachol can activate src family kinases was indicated further by the finding that carbachol induced an increase in tyrosine phosphorylation of p120-src substrate, which was inhibited by PP1.	Carbachol	5-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	28-31
10348664-5	1999	That carbachol can activate src family kinases was indicated further by the finding that carbachol induced an increase in tyrosine phosphorylation of p120-src substrate, which was inhibited by PP1.	Carbachol	5-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	155-158
10348664-5	1999	That carbachol can activate src family kinases was indicated further by the finding that carbachol induced an increase in tyrosine phosphorylation of p120-src substrate, which was inhibited by PP1.	Carbachol	5-14	neuropeptide Y receptor Y4	Homo sapiens	193-196
10348664-5	1999	That carbachol can activate src family kinases was indicated further by the finding that carbachol induced an increase in tyrosine phosphorylation of p120-src substrate, which was inhibited by PP1.	Carbachol	89-98	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	28-31
10348664-5	1999	That carbachol can activate src family kinases was indicated further by the finding that carbachol induced an increase in tyrosine phosphorylation of p120-src substrate, which was inhibited by PP1.	Carbachol	89-98	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	155-158
10348664-5	1999	That carbachol can activate src family kinases was indicated further by the finding that carbachol induced an increase in tyrosine phosphorylation of p120-src substrate, which was inhibited by PP1.	Carbachol	89-98	neuropeptide Y receptor Y4	Homo sapiens	193-196
10348664-8	1999	In contrast to the results with carbachol, H2O2 potentiated EGF-induced tyrosine phosphorylation.	Carbachol	32-41	epidermal growth factor	Homo sapiens	60-63
10050013-2	1999	We have investigated, with a combined in vitro and in vivo approach, the influence on insulin and glucagon release stimulated by the cholinergic, muscarinic agonist carbachol of different NO modulators, i.e. the nitric oxide synthase (NOS) inhibitors NG-nitro-L-arginine methyl ester (L-NAME), NG-monomethyl-L-arginine (L-NMMA) and 7-nitroindazole as well as the intracellular NO donor hydroxylamine.	Carbachol	165-174	insulin	Homo sapiens	86-93
10050013-4	1999	At basal glucose (7 mM) carbachol dose-dependently stimulated insulin release from isolated islets with a half-maximal response at approximately 1 microM of the agonist.	Carbachol	24-33	insulin	Homo sapiens	62-69
10050013-7	1999	Carbachol-stimulated islets displayed an increased insulin release and a suppressed glucagon release in the presence of L-NAME, L-NMMA or 7-nitroindazole.	Carbachol	0-9	insulin	Homo sapiens	51-58
10050013-9	1999	The intracellular NO donor hydroxylamine dose-dependently inhibited carbachol-induced insulin release but stimulated glucagon release only at a low concentration (3 microM).	Carbachol	68-77	insulin	Homo sapiens	86-93
10050013-11	1999	In islets depolarized with 30 mM K+ in the presence of the KATP channel opener diazoxide, NOS inhibition by 5 mM L-NAME still markedly potentiated carbachol-induced insulin release (although less so than in normal islets) and suppressed glucagon release.	Carbachol	147-156	insulin	Homo sapiens	165-172
10082202-2	1999	ATP, carbachol and thapsigargin increased endothelial [Ca2+]i in rabbit aortic valve loaded with a leakage resistant, fluorescent Ca2+ indicator, fura-PE3.	Carbachol	5-14	carbonic anhydrase 2	Oryctolagus cuniculus	55-58
10082202-2	1999	ATP, carbachol and thapsigargin increased endothelial [Ca2+]i in rabbit aortic valve loaded with a leakage resistant, fluorescent Ca2+ indicator, fura-PE3.	Carbachol	5-14	carbonic anhydrase 2	Oryctolagus cuniculus	130-133
10082202-7	1999	When the increase in endothelial [Ca2+]i was plotted against the relaxation, the carbachol-induced increase in [Ca2+]i elicited greater relaxation than did ATP or thapsigargin at a given [Ca2+]i.	Carbachol	81-90	carbonic anhydrase 2	Oryctolagus cuniculus	34-37
10082202-7	1999	When the increase in endothelial [Ca2+]i was plotted against the relaxation, the carbachol-induced increase in [Ca2+]i elicited greater relaxation than did ATP or thapsigargin at a given [Ca2+]i.	Carbachol	81-90	carbonic anhydrase 2	Oryctolagus cuniculus	112-115
10082202-7	1999	When the increase in endothelial [Ca2+]i was plotted against the relaxation, the carbachol-induced increase in [Ca2+]i elicited greater relaxation than did ATP or thapsigargin at a given [Ca2+]i.	Carbachol	81-90	carbonic anhydrase 2	Oryctolagus cuniculus	112-115
9915989-2	1999	We previously demonstrated that TNF-alpha induces a small, delayed follicular stage-dependent increase in intracellular Ca2+ concentration ([Ca2+]i) in hen granulosa cells and promotes carbachol (Cch)-induced mobilization of Ca2+ from intracellular stores in cells otherwise unresponsive to the cytokine.	Carbachol	185-194	tumor necrosis factor	Homo sapiens	32-41
9915989-2	1999	We previously demonstrated that TNF-alpha induces a small, delayed follicular stage-dependent increase in intracellular Ca2+ concentration ([Ca2+]i) in hen granulosa cells and promotes carbachol (Cch)-induced mobilization of Ca2+ from intracellular stores in cells otherwise unresponsive to the cytokine.	Carbachol	196-199	tumor necrosis factor	Homo sapiens	32-41
9925822-8	1999	Moreover, carbachol stimulated GFP-MK2 translocation to the cytoplasm in the absence of anisomycin.	Carbachol	10-19	MAPK activated protein kinase 2	Homo sapiens	35-38
10348664-3	1999	Carbachol induced time-dependent increases in phosphotyrosine immunoreactivity of several protein bands, which were quantitated, and immunoprecipitation was used to identify the adhesion-related proteins focal adhesion kinase, p130Cas/HEF1, and paxillin, and three shc adapter proteins.	Carbachol	0-9	BCAR1 scaffold protein, Cas family member	Homo sapiens	227-234
10348664-3	1999	Carbachol induced time-dependent increases in phosphotyrosine immunoreactivity of several protein bands, which were quantitated, and immunoprecipitation was used to identify the adhesion-related proteins focal adhesion kinase, p130Cas/HEF1, and paxillin, and three shc adapter proteins.	Carbachol	0-9	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	235-239
10348664-4	1999	Carbachol-induced tyrosine phosphorylation of the adhesion-related proteins was mediated by muscarinic receptors, and was inhibited by a src family kinase inhibitor, PP1.	Carbachol	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	137-140
10348664-4	1999	Carbachol-induced tyrosine phosphorylation of the adhesion-related proteins was mediated by muscarinic receptors, and was inhibited by a src family kinase inhibitor, PP1.	Carbachol	0-9	neuropeptide Y receptor Y4	Homo sapiens	166-169
9882625-1	1999	The signalling pathway leading to an activation of mitogen-activated protein (MAP) kinase subtypes Erk-1 and -2 upon stimulation of muscarinic receptor with carbachol in human neuroblastoma SK-N-BE2(C) cells was investigated.	Carbachol	157-166	mitogen-activated protein kinase 3	Homo sapiens	99-111
9882625-2	1999	Carbachol activated Erk-1/-2 by stimulating M3 muscarinic receptor, as determined by specific antagonists for individual muscarinic receptors.	Carbachol	0-9	mitogen-activated protein kinase 3	Homo sapiens	20-28
9882625-2	1999	Carbachol activated Erk-1/-2 by stimulating M3 muscarinic receptor, as determined by specific antagonists for individual muscarinic receptors.	Carbachol	0-9	cholinergic receptor muscarinic 3	Homo sapiens	44-66
9882625-3	1999	The activation of Erk-1/-2 by carbachol was blocked by the inhibition or down-regulation of protein kinase C (PKC).	Carbachol	30-39	mitogen-activated protein kinase 3	Homo sapiens	18-26
9882625-3	1999	The activation of Erk-1/-2 by carbachol was blocked by the inhibition or down-regulation of protein kinase C (PKC).	Carbachol	30-39	protein kinase C epsilon	Homo sapiens	110-113
9882625-4	1999	Among the multiple PKC isoforms expressed in SK-N-BE2(C) cells, only PKCepsilon was activated by the treatment of carbachol, and selective down-regulation of PKCepsilon was sufficient to block Erk-1/-2 activation.	Carbachol	114-123	protein kinase C epsilon	Homo sapiens	19-22
9882625-4	1999	Among the multiple PKC isoforms expressed in SK-N-BE2(C) cells, only PKCepsilon was activated by the treatment of carbachol, and selective down-regulation of PKCepsilon was sufficient to block Erk-1/-2 activation.	Carbachol	114-123	protein kinase C epsilon	Homo sapiens	69-79
9882625-5	1999	Carbachol treatment induced activation of the serine/threonine protein kinase Raf, and an inhibition of Raf blocked Erk-1/-2 activation.	Carbachol	0-9	zinc fingers and homeoboxes 2	Homo sapiens	78-81
9882625-5	1999	Carbachol treatment induced activation of the serine/threonine protein kinase Raf, and an inhibition of Raf blocked Erk-1/-2 activation.	Carbachol	0-9	zinc fingers and homeoboxes 2	Homo sapiens	104-107
9882625-5	1999	Carbachol treatment induced activation of the serine/threonine protein kinase Raf, and an inhibition of Raf blocked Erk-1/-2 activation.	Carbachol	0-9	mitogen-activated protein kinase 3	Homo sapiens	116-124
9882625-6	1999	Ectopic expression of inhibitory small GTPase Ras, RasN17, blocked the carbachol-induced Raf activation without affecting the activation of PKCepsilon, while the inhibition of PKC blocked the Raf activation.	Carbachol	71-80	zinc fingers and homeoboxes 2	Homo sapiens	89-92
9882625-7	1999	Thus, these results suggest that carbachol-induced activation of PKCepsilon mediates Erk-1/-2 activation by a sequential activation of Ras, Raf and MAP kinase kinase.	Carbachol	33-42	protein kinase C epsilon	Homo sapiens	65-75
9882625-7	1999	Thus, these results suggest that carbachol-induced activation of PKCepsilon mediates Erk-1/-2 activation by a sequential activation of Ras, Raf and MAP kinase kinase.	Carbachol	33-42	mitogen-activated protein kinase 3	Homo sapiens	85-93
9882625-7	1999	Thus, these results suggest that carbachol-induced activation of PKCepsilon mediates Erk-1/-2 activation by a sequential activation of Ras, Raf and MAP kinase kinase.	Carbachol	33-42	zinc fingers and homeoboxes 2	Homo sapiens	140-143
9920901-8	1999	RGS1 showed approximately 1000-fold higher potency in inhibiting carbachol than CCK-dependent signaling.	Carbachol	65-74	regulator of G-protein signaling 1	Mus musculus	0-4
9920901-9	1999	RGS16 was as effective as RGS1 in inhibiting carbachol-dependent signaling but only partially inhibited the response to CCK.	Carbachol	45-54	regulator of G-protein signaling 16	Mus musculus	0-5
9920901-9	1999	RGS16 was as effective as RGS1 in inhibiting carbachol-dependent signaling but only partially inhibited the response to CCK.	Carbachol	45-54	regulator of G-protein signaling 1	Mus musculus	0-4
9920901-10	1999	By contrast, RGS2 inhibited the response to carbachol and CCK with equal potency.	Carbachol	44-53	regulator of G-protein signaling 2	Mus musculus	13-17
10226762-7	1999	BRL 37344A, a selective beta 3-adrenoceptor agonist produced concentration-dependent relaxation of carbachol-precontracted fundic and ductal strips.	Carbachol	99-108	beta-3 adrenergic receptor	Ovis aries	24-43
9873004-4	1999	In cells expressing homotetrameric wild type or mutant RyR1, the amplitude of 10 mM caffeine-induced Ca2+ release was correlated significantly with the amplitude of carbachol- or thapsigargin-induced Ca2+ release, indicating that maximal drug-induced Ca2+ release depends on the size of the endoplasmic reticulum Ca2+ store.	Carbachol	165-174	ryanodine receptor 1	Homo sapiens	55-59
9872844-8	1999	CGRP (10(-)6 M) reduced by more than 75% the extent of the contraction evoked by 10(-)6 M of carbamylcholine and its protector effect was totally abolished in bronchi showing clear morphological manifestation of inflammatory reaction.	Carbachol	93-108	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
9886064-5	1999	The results also showed that CREB phosphorylation in immature OLG precursor cells could be up-regulated by treatment with histamine, carbachol, glutamate, and ATP (neuroligands known to increase Ca2+ levels in these cells), by signaling cascade(s) that involve a protein kinase C activity, as well as the mitogen-activated protein kinase pathway.	Carbachol	133-142	cAMP responsive element binding protein 1	Rattus norvegicus	29-33
9874691-5	1999	In control cells expressing alpha1B, alpha2, and beta3 Ca channel subunits and m2 receptors, carbachol (1 microM) inhibited whole-cell currents by approximately 80% compared with only approximately 55% inhibition in cells also expressing exogenous RGS protein.	Carbachol	93-102	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	37-54
9874691-5	1999	In control cells expressing alpha1B, alpha2, and beta3 Ca channel subunits and m2 receptors, carbachol (1 microM) inhibited whole-cell currents by approximately 80% compared with only approximately 55% inhibition in cells also expressing exogenous RGS protein.	Carbachol	93-102	paired like homeodomain 2	Homo sapiens	248-251
9973241-3	1999	Two NO donors inhibited activation of neuronal NO synthase (nNOS) in response to the muscarinic receptor agonist carbachol in Chinese hamster ovary (CHO) cells stably transfected with the M1 muscarinic receptor and nNOS.	Carbachol	113-122	nitric oxide synthase 1	Homo sapiens	60-64
9973241-3	1999	Two NO donors inhibited activation of neuronal NO synthase (nNOS) in response to the muscarinic receptor agonist carbachol in Chinese hamster ovary (CHO) cells stably transfected with the M1 muscarinic receptor and nNOS.	Carbachol	113-122	nitric oxide synthase 1	Homo sapiens	215-219
9973241-11	1999	A decrease in the carbachol-mediated transient Ca2+ peak was observed in cells that express nNOS as compared to cells lacking the enzyme, suggesting that endogenous NO might inhibit receptor mediated Ca2+ signaling.	Carbachol	18-27	nitric oxide synthase 1	Homo sapiens	92-96
9815052-0	1998	Supramaximal CCK and CCh concentrations abolish VIP potentiation by inhibiting adenylyl cyclase activity.	Carbachol	21-24	vasoactive intestinal peptide	Rattus norvegicus	48-51
10193897-4	1999	The inhibition of the carbachol (1 mM) response by CRH was concentration-dependent (EC50 = 154 +/- 1.8 nM).	Carbachol	22-31	corticotropin releasing hormone	Mus musculus	51-54
10193897-5	1999	Calcium responses to sub-maximally effective concentrations of PACAP (5 nM), VIP (400 nM) and carbachol (1 mM) were abolished by prior exposure to CRH (1 microM).	Carbachol	94-103	corticotropin releasing hormone	Mus musculus	147-150
10049140-1	1998	The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change.	Carbachol	140-155	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	47-79
10049140-1	1998	The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change.	Carbachol	140-155	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	81-86
10049140-1	1998	The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change.	Carbachol	157-161	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	47-79
10049140-1	1998	The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change.	Carbachol	157-161	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	81-86
10049140-1	1998	The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change.	Carbachol	252-256	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	47-79
10049140-1	1998	The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change.	Carbachol	252-256	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	81-86
10049140-4	1998	Spectral variations are also observed that are indicative of both the displacement of the anesthetics from the nAChR upon the addition of Carb and physical interactions that occur between the anesthetics and binding site residues.	Carbachol	138-142	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	111-116
9802318-3	1998	Relaxation by CGRP (1 microM) was determined in cells maximally contracted by carbachol (CCh, 1 nM).	Carbachol	78-87	calcitonin related polypeptide alpha	Homo sapiens	14-18
9802318-3	1998	Relaxation by CGRP (1 microM) was determined in cells maximally contracted by carbachol (CCh, 1 nM).	Carbachol	89-92	calcitonin related polypeptide alpha	Homo sapiens	14-18
9802318-5	1998	CCh-induced contraction was inhibited by 1 microM CGRP (maximum: 69+/-5% within 60 sec); similarly, exposure of cells to sodium nitroprussiate (SNP), 1 microM, fully inhibited contraction (maximum: 89+/-8% within 30 sec).	Carbachol	0-3	calcitonin related polypeptide alpha	Homo sapiens	50-54
9863995-4	1998	In tracheal strips precontracted with carbachol, hypocapnic challenge (0% CO2) produced increases in tension, pHi, and [Ca2+]i.	Carbachol	38-47	glucose-6-phosphate isomerase	Homo sapiens	110-113
9853304-0	1998	Potentiation by neurotensin of carbachol-induced tension development in beta-escin-skinned smooth muscle of guinea-pig ileum.	Carbachol	31-40	neurotensin/neuromedin N	Cavia porcellus	16-27
9853304-1	1998	Effect of neurotensin (NT) on carbachol(CCh)-induced tension development due to Ca2+ release from intracellular stores was investigated in beta-escin-skinned smooth muscle of guinea-pig ileum.	Carbachol	30-39	neurotensin/neuromedin N	Cavia porcellus	10-21
9853304-1	1998	Effect of neurotensin (NT) on carbachol(CCh)-induced tension development due to Ca2+ release from intracellular stores was investigated in beta-escin-skinned smooth muscle of guinea-pig ileum.	Carbachol	30-39	neurotensin/neuromedin N	Cavia porcellus	23-25
11286343-4	1998	The mPRF was microinjected with 0.25 ml saline, carbachol (4.0 microg), neostigmine (6.7 microg), or morphine sulfate (14.7 microg), and TFL measures were obtained in response to radiant heat.	Carbachol	48-57	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	4-8
11286343-5	1998	During wakefulness TFL (% increase) was not increased by morphine or saline, but was significantly increased by mPRF administration of carbachol (42.4%) and neostigmine (35.2%).	Carbachol	135-144	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	112-116
9786868-4	1998	Chronic exposure of cells expressing alpha3 beta2 AChRs or alpha3 beta2 alpha5 AChRs to nicotine or carbamylcholine increased their amount up to 24-fold but had no effect on the amount of alpha3beta4 or alpha3 beta4 alpha5 AChRs, i.e. the up-regulation of alpha3 AChRs depended on the presence of beta2 but not beta4 subunits in the AChRs.	Carbachol	100-115	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	44-49
9786868-4	1998	Chronic exposure of cells expressing alpha3 beta2 AChRs or alpha3 beta2 alpha5 AChRs to nicotine or carbamylcholine increased their amount up to 24-fold but had no effect on the amount of alpha3beta4 or alpha3 beta4 alpha5 AChRs, i.e. the up-regulation of alpha3 AChRs depended on the presence of beta2 but not beta4 subunits in the AChRs.	Carbachol	100-115	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	66-71
9786868-4	1998	Chronic exposure of cells expressing alpha3 beta2 AChRs or alpha3 beta2 alpha5 AChRs to nicotine or carbamylcholine increased their amount up to 24-fold but had no effect on the amount of alpha3beta4 or alpha3 beta4 alpha5 AChRs, i.e. the up-regulation of alpha3 AChRs depended on the presence of beta2 but not beta4 subunits in the AChRs.	Carbachol	100-115	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	66-71
9765228-0	1998	Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells.	Carbachol	0-9	epidermal growth factor receptor	Homo sapiens	40-72
9765228-5	1998	Further studies revealed that CCh stimulated an increase in both phosphorylation and activity of the extracellular signal-regulated kinase (ERK) isoforms of mitogen-activated protein kinase.	Carbachol	30-33	mitogen-activated protein kinase 1	Homo sapiens	101-138
9765228-5	1998	Further studies revealed that CCh stimulated an increase in both phosphorylation and activity of the extracellular signal-regulated kinase (ERK) isoforms of mitogen-activated protein kinase.	Carbachol	30-33	mitogen-activated protein kinase 1	Homo sapiens	140-143
9765228-7	1998	Phosphorylation of ERK in response to CCh was mimicked by the protein kinase C (PKC) activator, phorbol myristate acetate (100 nM), but was not altered by the PKC inhibitor GF 109203X (1 microM).	Carbachol	38-41	mitogen-activated protein kinase 1	Homo sapiens	19-22
9765228-9	1998	Immunoprecipitation/Western blot studies revealed that CCh stimulated tyrosine phosphorylation of the EGF receptor (EGFr) and increased co-immunoprecipitation of the adapter proteins, Shc and Grb2, with the EGFr.	Carbachol	55-58	epidermal growth factor receptor	Homo sapiens	102-114
9765228-9	1998	Immunoprecipitation/Western blot studies revealed that CCh stimulated tyrosine phosphorylation of the EGF receptor (EGFr) and increased co-immunoprecipitation of the adapter proteins, Shc and Grb2, with the EGFr.	Carbachol	55-58	epidermal growth factor receptor	Homo sapiens	116-120
9765228-9	1998	Immunoprecipitation/Western blot studies revealed that CCh stimulated tyrosine phosphorylation of the EGF receptor (EGFr) and increased co-immunoprecipitation of the adapter proteins, Shc and Grb2, with the EGFr.	Carbachol	55-58	SHC adaptor protein 1	Homo sapiens	184-187
9765228-9	1998	Immunoprecipitation/Western blot studies revealed that CCh stimulated tyrosine phosphorylation of the EGF receptor (EGFr) and increased co-immunoprecipitation of the adapter proteins, Shc and Grb2, with the EGFr.	Carbachol	55-58	growth factor receptor bound protein 2	Homo sapiens	192-196
9765228-9	1998	Immunoprecipitation/Western blot studies revealed that CCh stimulated tyrosine phosphorylation of the EGF receptor (EGFr) and increased co-immunoprecipitation of the adapter proteins, Shc and Grb2, with the EGFr.	Carbachol	55-58	epidermal growth factor receptor	Homo sapiens	207-211
9765228-10	1998	An inhibitor of EGFr phosphorylation, tyrphostin AG1478 (1 microM), reversed CCh-stimulated phosphorylation of both EGFr and ERK.	Carbachol	77-80	epidermal growth factor receptor	Homo sapiens	16-20
9765228-10	1998	An inhibitor of EGFr phosphorylation, tyrphostin AG1478 (1 microM), reversed CCh-stimulated phosphorylation of both EGFr and ERK.	Carbachol	77-80	epidermal growth factor receptor	Homo sapiens	116-120
9765228-10	1998	An inhibitor of EGFr phosphorylation, tyrphostin AG1478 (1 microM), reversed CCh-stimulated phosphorylation of both EGFr and ERK.	Carbachol	77-80	mitogen-activated protein kinase 1	Homo sapiens	125-128
9765228-12	1998	We conclude that CCh activates ERK in T84 cells via a mechanism involving transactivation of the EGFr, and that this pathway constitutes an inhibitory signaling pathway by which chloride secretory responses to CCh may be negatively regulated.	Carbachol	17-20	mitogen-activated protein kinase 1	Homo sapiens	31-34
9765228-12	1998	We conclude that CCh activates ERK in T84 cells via a mechanism involving transactivation of the EGFr, and that this pathway constitutes an inhibitory signaling pathway by which chloride secretory responses to CCh may be negatively regulated.	Carbachol	17-20	epidermal growth factor receptor	Homo sapiens	97-101
9809810-6	1998	Carbachol, insulin, and EGF caused a significant increase in TK immunoreactive protein content which was blocked by HAC and DHC.	Carbachol	0-9	TXK tyrosine kinase	Homo sapiens	61-63
9809810-7	1998	In BLM, carbachol significantly stimulated HCO3-dependent 22Na uptake and this effect was totally prevented by the monoclonal antibody against TK.	Carbachol	8-17	TXK tyrosine kinase	Homo sapiens	143-145
9809810-8	1998	In cultured proximal tubule cells, carbachol, EGF and insulin at physiologic concentration caused a significant stimulation of the cotransporter activity and this effect was completely blocked by the TK inhibitor, HAC.	Carbachol	35-44	TXK tyrosine kinase	Homo sapiens	200-202
9756505-10	1998	Carbachol activation of JNK1 resulted in induction of c-Jun (protein) transcriptional activity and in stimulation of parietal cell mRNA content of c-jun.	Carbachol	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Canis lupus familiaris	54-59
9756505-10	1998	Carbachol activation of JNK1 resulted in induction of c-Jun (protein) transcriptional activity and in stimulation of parietal cell mRNA content of c-jun.	Carbachol	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Canis lupus familiaris	147-152
9756505-11	1998	In conclusion, our data indicate that carbachol induces JNK activity in gastric parietal cells via intracellular Ca2+-dependent, PKC-independent pathways, leading to induction of c-jun gene expression via phosphorylation and transcriptional activation of c-Jun.	Carbachol	38-47	Jun proto-oncogene, AP-1 transcription factor subunit	Canis lupus familiaris	179-184
9756505-11	1998	In conclusion, our data indicate that carbachol induces JNK activity in gastric parietal cells via intracellular Ca2+-dependent, PKC-independent pathways, leading to induction of c-jun gene expression via phosphorylation and transcriptional activation of c-Jun.	Carbachol	38-47	Jun proto-oncogene, AP-1 transcription factor subunit	Canis lupus familiaris	255-260
9751489-5	1998	In tests of several neurotransmitters, only the cholinergic agonists carbachol and bethanechol stimulated peptide secretion in a dose-dependent fashion (by 2.3 +/- 0.5- and 1.7 +/- 0.3-fold at 1000 microM; P &lt; 0.05-0.001); the beta-adrenergic agonist isoproterenol and the chloride channel inhibitor gamma-aminobutyric acid did not affect release of GLP-1.	Carbachol	69-78	glucagon	Mus musculus	353-358
9756635-1	1998	Desensitization of human muscarinic acetylcholine receptor m2 subtypes (hm2 receptors) stably expressed in chinese hamster ovary cells was measured as decreases in the carbamylcholine-stimulated [35S]GTPgammaS binding activity in membrane preparations after pre-treatment of cells with carbamylcholine.	Carbachol	168-183	cholinergic receptor muscarinic 2	Homo sapiens	25-61
9756635-1	1998	Desensitization of human muscarinic acetylcholine receptor m2 subtypes (hm2 receptors) stably expressed in chinese hamster ovary cells was measured as decreases in the carbamylcholine-stimulated [35S]GTPgammaS binding activity in membrane preparations after pre-treatment of cells with carbamylcholine.	Carbachol	168-183	cholinergic receptor muscarinic 2	Homo sapiens	72-75
9756635-1	1998	Desensitization of human muscarinic acetylcholine receptor m2 subtypes (hm2 receptors) stably expressed in chinese hamster ovary cells was measured as decreases in the carbamylcholine-stimulated [35S]GTPgammaS binding activity in membrane preparations after pre-treatment of cells with carbamylcholine.	Carbachol	286-301	cholinergic receptor muscarinic 2	Homo sapiens	72-75
9756635-2	1998	The extent of carbamylcholine-stimulated [35S]GTPgammaS binding activity was found to decrease to 64% following pretreatment of cells with 10 microM carbamylcholine for 30 min, and under the same conditions 51-59% of hm2 receptors were sequestered/internalized as assessed by decreases in the [3H]N-methylscopolamine binding activity on the cell surface.	Carbachol	14-29	cholinergic receptor muscarinic 2	Homo sapiens	217-220
9756635-2	1998	The extent of carbamylcholine-stimulated [35S]GTPgammaS binding activity was found to decrease to 64% following pretreatment of cells with 10 microM carbamylcholine for 30 min, and under the same conditions 51-59% of hm2 receptors were sequestered/internalized as assessed by decreases in the [3H]N-methylscopolamine binding activity on the cell surface.	Carbachol	149-164	cholinergic receptor muscarinic 2	Homo sapiens	217-220
9756635-3	1998	A similar reduction in the carbamylcholine-stimulated [35S]GTPgammaS binding activity was observed by pretreatment of cells with 5 nM propylbenzylylcholine mustard, which irreversibly bound to and inactivated 58% of the hm2 receptors.	Carbachol	27-42	cholinergic receptor muscarinic 2	Homo sapiens	220-223
9727040-4	1998	The effects of carbachol and bombesin on p38 MAP kinase activity were similar to those of CCK, whereas phorbol ester, epidermal growth factor, and vasoactive intestinal polypeptide stimulated p38 MAP kinase by 2-fold or less.	Carbachol	15-24	mitogen activated protein kinase 14	Rattus norvegicus	41-44
10353591-3	1999	In diabetics, the PKC activity in the nucleus fraction was significantly decreased by about 63% in the resting condition and that in the cytosol fraction was significantly increased by about 135% after the treatment with 10 microM CCh for 10 min compared to controls.	Carbachol	231-234	protein kinase C, beta	Rattus norvegicus	18-21
9875705-5	1998	Protein kinase C (PKC) inhibitors, H-7 and calphostin C, inhibited the carbachol-induced upregulation.	Carbachol	71-80	solute carrier family 9 member A2	Rattus norvegicus	35-55
9815039-3	1998	Carbachol (10(-4) M) was the weakest acid secretagogue but caused the strongest Na+/H+ exchange activation, which was completely blocked by 1 microM HOE-642 (selective for NHE1); histamine (10(-4) M) and forskolin (10(-5) M) were stronger stimulants of [14C]aminopyrine accumulation but weaker stimulants of Na+/H+ exchange activity.	Carbachol	0-9	sodium/hydrogen exchanger 1	Oryctolagus cuniculus	172-176
9815040-7	1998	However, when parietal cells were preincubated with IL-1beta (0.5-5 pg/ml) for 10 min before the addition of histamine or carbachol, the response to these secretagogues was reduced by 35 and 67%, respectively.	Carbachol	122-131	interleukin 1 beta	Rattus norvegicus	52-60
9815040-9	1998	Preincubation of parietal cells with IL-1beta failed to alter histamine-stimulated cAMP production but markedly inhibited carbachol-induced formation of D-myo-inositol 1,4, 5-trisphosphate.	Carbachol	122-131	interleukin 1 beta	Rattus norvegicus	37-45
9815040-10	1998	In fura 2-loaded, purified parietal cells, 10 min preincubation with IL-1beta dramatically reduced the initial transient peak elevation of intracellular Ca2+ concentration in response to carbachol.	Carbachol	187-196	interleukin 1 beta	Rattus norvegicus	69-77
11717867-2	1998	METHODS: The fura-2 microfluorimetry was used to measure changes of [Ca2+]i in OHCs of the guinea pig cochlea after application of acetylcholine, ATP and carbacholine.	Carbachol	154-166	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	69-72
11717867-3	1998	RESULTS: Acetylcholine, ATP and carbacholine increased [Ca2+]i (acetylcholine: 0.74 +/- 0.12 mumol/L, ATP: 0.65 +/- 0.11 mumol/L, carbacholine: 1.16 +/- 0.27 mumol/L) in OHCs in the presence of extracellular Ca2+.	Carbachol	32-44	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	56-59
11717867-3	1998	RESULTS: Acetylcholine, ATP and carbacholine increased [Ca2+]i (acetylcholine: 0.74 +/- 0.12 mumol/L, ATP: 0.65 +/- 0.11 mumol/L, carbacholine: 1.16 +/- 0.27 mumol/L) in OHCs in the presence of extracellular Ca2+.	Carbachol	32-44	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	208-211
11717867-3	1998	RESULTS: Acetylcholine, ATP and carbacholine increased [Ca2+]i (acetylcholine: 0.74 +/- 0.12 mumol/L, ATP: 0.65 +/- 0.11 mumol/L, carbacholine: 1.16 +/- 0.27 mumol/L) in OHCs in the presence of extracellular Ca2+.	Carbachol	130-142	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	56-59
11717867-5	1998	CONCLUSION: Acetylcholine and carbacholine, the cholinergic mascarinic agonists, increased [Ca2+]i in OHCs by acting at receptor-induced ion channel resulting in Ca2+ efflux.	Carbachol	30-42	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	92-95
11717867-5	1998	CONCLUSION: Acetylcholine and carbacholine, the cholinergic mascarinic agonists, increased [Ca2+]i in OHCs by acting at receptor-induced ion channel resulting in Ca2+ efflux.	Carbachol	30-42	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	162-165
9736657-7	1998	The developmental increase in atrial CNTF receptor mRNA was enhanced by stimulating muscarinic receptors with carbachol in ovo and was inhibited by blocking muscarinic cholinergic receptors with atropine.	Carbachol	110-119	ciliary neurotrophic factor	Gallus gallus	37-41
9730946-1	1998	In the estrogen-treated rat myometrium, carbachol increased the generation of inositol phosphates by stimulating the muscarinic receptor-Gq/G11-phospholipase C-beta3 (PLC-beta3) cascade.	Carbachol	40-49	phospholipase C beta 3	Rattus norvegicus	167-176
9730946-2	1998	Exposure to carbachol resulted in a rapid and specific (homologous) attenuation of the subsequent muscarinic responses in terms of inositol phosphate production, PLC-beta3 translocation to membrane, and contraction.	Carbachol	12-21	phospholipase C beta 3	Rattus norvegicus	162-171
9726232-2	1998	In this study, we examined whether CCK-8 stimulates the Ca2+-independent form of PLA2 in isolated rat islets, in comparison with stimulation by the PLA2-activating cholinergic agonist carbachol.	Carbachol	184-193	phospholipase A2 group IB	Rattus norvegicus	148-152
9732369-4	1998	Choline, a normal component of growth media, showed an efficacy comparable to acetylcholine and carbachol at Hm1(Ser388Tyr, Thr389Pro) receptors.	Carbachol	96-105	cholinergic receptor muscarinic 1	Homo sapiens	109-112
9774217-2	1998	Low density lipoprotein (LDL: 20-80 mg/dl) and lipoprotein(a) [Lp(a); 10-80 mg/dl] inhibited catecholamine secretion induced by carbachol, an activator of nicotinic acetylcholine receptor-ion channels.	Carbachol	128-137	plasminogen	Bos taurus	47-61
9774217-2	1998	Low density lipoprotein (LDL: 20-80 mg/dl) and lipoprotein(a) [Lp(a); 10-80 mg/dl] inhibited catecholamine secretion induced by carbachol, an activator of nicotinic acetylcholine receptor-ion channels.	Carbachol	128-137	plasminogen	Bos taurus	63-68
9774217-3	1998	LDL and Lp(a) suppressed carbachol-induced 22Na+ influx as well as 45Ca2+ influx in a concentration-dependent manner similar to that of catecholamine secretion.	Carbachol	25-34	plasminogen	Bos taurus	8-13
9774217-6	1998	Like LDL and Lp(a), a synthetic peptide homologous to human plasma apolipoprotein B (apoB), apoB fragment(3358-3372)-amide (3-60 microM), attenuated 22Na+ influx, 45Ca2+ influx, and catecholamine secretion caused by carbachol.	Carbachol	216-225	lipoprotein(a)	Homo sapiens	13-18
9774217-6	1998	Like LDL and Lp(a), a synthetic peptide homologous to human plasma apolipoprotein B (apoB), apoB fragment(3358-3372)-amide (3-60 microM), attenuated 22Na+ influx, 45Ca2+ influx, and catecholamine secretion caused by carbachol.	Carbachol	216-225	apolipoprotein B	Homo sapiens	67-83
9774217-6	1998	Like LDL and Lp(a), a synthetic peptide homologous to human plasma apolipoprotein B (apoB), apoB fragment(3358-3372)-amide (3-60 microM), attenuated 22Na+ influx, 45Ca2+ influx, and catecholamine secretion caused by carbachol.	Carbachol	216-225	apolipoprotein B	Homo sapiens	85-89
9774217-6	1998	Like LDL and Lp(a), a synthetic peptide homologous to human plasma apolipoprotein B (apoB), apoB fragment(3358-3372)-amide (3-60 microM), attenuated 22Na+ influx, 45Ca2+ influx, and catecholamine secretion caused by carbachol.	Carbachol	216-225	apolipoprotein B	Homo sapiens	92-96
9815052-1	1998	Exocrine pancreatic secretion stimulated by vasoactive intestinal polypeptide (VIP), which acts through the adenylyl cyclase-cAMP pathway, is potentiated by stimulation with other secretagogues such as CCK and carbachol (CCh).	Carbachol	210-219	vasoactive intestinal peptide	Rattus norvegicus	44-77
9815052-1	1998	Exocrine pancreatic secretion stimulated by vasoactive intestinal polypeptide (VIP), which acts through the adenylyl cyclase-cAMP pathway, is potentiated by stimulation with other secretagogues such as CCK and carbachol (CCh).	Carbachol	210-219	vasoactive intestinal peptide	Rattus norvegicus	79-82
9815052-1	1998	Exocrine pancreatic secretion stimulated by vasoactive intestinal polypeptide (VIP), which acts through the adenylyl cyclase-cAMP pathway, is potentiated by stimulation with other secretagogues such as CCK and carbachol (CCh).	Carbachol	210-219	cholecystokinin	Rattus norvegicus	202-205
9815052-1	1998	Exocrine pancreatic secretion stimulated by vasoactive intestinal polypeptide (VIP), which acts through the adenylyl cyclase-cAMP pathway, is potentiated by stimulation with other secretagogues such as CCK and carbachol (CCh).	Carbachol	221-224	vasoactive intestinal peptide	Rattus norvegicus	44-77
9815052-1	1998	Exocrine pancreatic secretion stimulated by vasoactive intestinal polypeptide (VIP), which acts through the adenylyl cyclase-cAMP pathway, is potentiated by stimulation with other secretagogues such as CCK and carbachol (CCh).	Carbachol	221-224	vasoactive intestinal peptide	Rattus norvegicus	79-82
9815052-1	1998	Exocrine pancreatic secretion stimulated by vasoactive intestinal polypeptide (VIP), which acts through the adenylyl cyclase-cAMP pathway, is potentiated by stimulation with other secretagogues such as CCK and carbachol (CCh).	Carbachol	221-224	cholecystokinin	Rattus norvegicus	202-205
9815052-3	1998	In the present study, we examined the mechanisms by which supramaximal concentrations of CCK octapeptide (CCK-8) or CCh reduce the VIP-induced potentiation of amylase secretion from isolated rat pancreatic acini.	Carbachol	116-119	vasoactive intestinal peptide	Rattus norvegicus	131-134
9815052-4	1998	VIP-stimulated amylase secretion was potentiated by submaximal stimulatory concentrations of CCK-8 and CCh but was reduced by the same reagents at higher concentrations.	Carbachol	103-106	vasoactive intestinal peptide	Rattus norvegicus	0-3
9815052-6	1998	Moreover, supramaximal concentrations of CCK-8 or CCh inhibited VIP-stimulated intracellular cAMP production as well as adenylyl cyclase activity.	Carbachol	50-53	vasoactive intestinal peptide	Rattus norvegicus	64-67
9815052-8	1998	These results indicate that supramaximal concentrations of CCK-8 and CCh reduce the potentiating effect of VIP and forskolin on amylase secretion by inhibiting the adenylyl cyclase activity.	Carbachol	69-72	vasoactive intestinal peptide	Rattus norvegicus	107-110
9688692-3	1998	Intracerebroventricular infusions of ANG II, 0.75 mol/l NaCl, or carbachol caused increases in renal Na+ and K+ excretion, arterial pressure, and plasma AVP levels.	Carbachol	65-74	vasopressin-neurophysin 2-copeptin	Ovis aries	153-156
9688612-8	1998	We suggest that the Ca2+ influx-dependent regulation of the sustained KCa current in CCh-stimulated HSG cells is mediated by the uptake of Ca2+ into the internal Ca2+ store and release via the inositol 1,4,5-trisphosphate-sensitive channel.	Carbachol	85-88	casein kappa	Homo sapiens	70-73
9720586-7	1998	PTHrP (1-100 nM) relaxed carbachol-contracted bladder body and base by 15% and 45% respectively.	Carbachol	25-34	parathyroid hormone like hormone	Homo sapiens	0-5
9745899-1	1998	The report describes the results of a study the effect of pH and binding of six physiologically active compounds (isoproterenol, yohimbine, theophylline, propranolol, clonidine and carbachol) on the molecular structure of human serum albumin (HSA) using dynamic light scattering.	Carbachol	181-190	albumin	Homo sapiens	228-241
9825917-4	1998	However, our results shown that carbachol (a muscarinic acetylcholine receptor agonist), and ligands to other phospholipase C-linked receptors, promoted a rapid increase in the tyrosine phosphorylation of protein kinase Cdelta (PKCdelta), a member of the PKC family of proteins.	Carbachol	32-41	protein kinase C, delta	Rattus norvegicus	205-226
9825917-4	1998	However, our results shown that carbachol (a muscarinic acetylcholine receptor agonist), and ligands to other phospholipase C-linked receptors, promoted a rapid increase in the tyrosine phosphorylation of protein kinase Cdelta (PKCdelta), a member of the PKC family of proteins.	Carbachol	32-41	protein kinase C, delta	Rattus norvegicus	228-236
9825917-4	1998	However, our results shown that carbachol (a muscarinic acetylcholine receptor agonist), and ligands to other phospholipase C-linked receptors, promoted a rapid increase in the tyrosine phosphorylation of protein kinase Cdelta (PKCdelta), a member of the PKC family of proteins.	Carbachol	32-41	protein kinase C, delta	Rattus norvegicus	228-231
9825926-6	1998	VIP thus serves to decrease the EC50 for carbachol nearly three-fold.	Carbachol	41-50	vasoactive intestinal peptide	Rattus norvegicus	0-3
9825926-7	1998	Results are thus far consistent with the hypothesis that a sustained rise in the intracellular concentration of calcium ions induced by VIP accounts for synergistic secretion and the heightened sensitivity to carbachol.	Carbachol	209-218	vasoactive intestinal peptide	Rattus norvegicus	136-139
9877233-2	1998	It was observed that the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine methylester (L-NAME) markedly potentiated insulin release and modestly inhibited glucagon release induced by carbachol.	Carbachol	184-193	nitric oxide synthase 2	Homo sapiens	25-36
9877233-8	1998	Further, in the presence of diazoxide, a potent K+ ATP-channel opener, plus a depolarizing concentration of K+ the NOS-inhibitor L-NAME still markedly potentiated carbachol-induced insulin release and inhibited glucagon release.	Carbachol	163-172	insulin	Homo sapiens	181-188
9877233-12	1998	Furthermore, a series of perifusion experiments revealed that hydroxylamine greatly inhibited carbachol-induced insulin release without affecting the 45Ca2+ -efflux pattern.	Carbachol	94-103	insulin	Homo sapiens	112-119
9877233-13	1998	In summary, our results suggest that the inhibitory effect of NO on carbachol-induced insulin release is not to any significant extent exerted on the IP3-Ca2+ messenger system but rather through S-nitrosylation of critical thiol-residues in protein kinase C and/or other secretion-regulatory thiol groups.	Carbachol	68-77	insulin	Homo sapiens	86-93
9694941-2	1998	Bethanechol and carbachol produce dose-dependent increases in rat adrenal TH activity.	Carbachol	16-25	tyrosine hydroxylase	Rattus norvegicus	74-76
9678662-4	1998	Stimulation of the VH (defined as the ventral CA1 and its borders, ventral subiculum, and entorhinal cortex) with the cholinergic agonist carbachol was found to elevate locomotor activity, while pretreatment with the D2 receptor antagonist haloperidol blocked this effect.	Carbachol	138-147	carbonic anhydrase 1	Rattus norvegicus	46-49
9681447-2	1998	Serendipitously, however, we observed that pretreatment of Chinese hamster ovary (CHO) cells, which coexpress muscarinic M1 receptors and nNOS, with 3.3 microM or 1 mM carbachol (CCh) for 48 h resulted in marked enhancement of maximal muscarinic receptor-stimulated nNOS activity as determined by L-[3H]citrulline and cyclic [3H]GMP production.	Carbachol	168-177	nitric oxide synthase 1, neuronal	Mus musculus	138-142
9681447-2	1998	Serendipitously, however, we observed that pretreatment of Chinese hamster ovary (CHO) cells, which coexpress muscarinic M1 receptors and nNOS, with 3.3 microM or 1 mM carbachol (CCh) for 48 h resulted in marked enhancement of maximal muscarinic receptor-stimulated nNOS activity as determined by L-[3H]citrulline and cyclic [3H]GMP production.	Carbachol	168-177	nitric oxide synthase 1, neuronal	Mus musculus	266-270
9681447-6	1998	It is interesting that ionomycin-stimulated nNOS activity was greater in CCh-pretreated cells.	Carbachol	73-76	nitric oxide synthase 1, neuronal	Mus musculus	44-48
9655696-3	1998	The NO-donor SIN-1 and the cGMP analogs were able to inhibit contractions induced by activation of L-type Ca2+ channels (BAY-K-8644), by carbachol (CCh), and by cyclopiazonic acid (CPA), a blocker of sarcoplasmic Ca2+-ATPase.	Carbachol	137-146	MAPK associated protein 1	Homo sapiens	13-18
9655696-3	1998	The NO-donor SIN-1 and the cGMP analogs were able to inhibit contractions induced by activation of L-type Ca2+ channels (BAY-K-8644), by carbachol (CCh), and by cyclopiazonic acid (CPA), a blocker of sarcoplasmic Ca2+-ATPase.	Carbachol	148-151	MAPK associated protein 1	Homo sapiens	13-18
9683560-5	1998	Administration of angiotensin II as well as endothelin into the observation chamber caused a significant decrease of the mean capillary diameter (13 and 16% reduction, respectively) within 90 s. Carbachol, bradykinin, and histamine significantly increased the capillary diameter within 90 s (13, 20, and 18% increase, respectively).	Carbachol	195-204	angiotensinogen	Rattus norvegicus	18-32
9683731-5	1998	In rectal gland slices sgk-1 transcription was induced by exposure to hypertonic solution, reduction of the extracellular urea concentration, and addition of the secretagogues vasoactive intestinal polypeptide (VIP) and carbachol.	Carbachol	220-229	serum/glucocorticoid regulated kinase 1	Homo sapiens	23-28
9636140-4	1998	This report demonstrates that tyrosine phosphorylation of paxillin and FAK elicited by stimulation of muscarinic m3 receptors with the acetylcholine analog carbachol is inhibited by soluble peptides containing the arginine-glycine-aspartate motif (the recognition site for integrins found in adhesion proteins such as fibronectin) but is unaffected by peptides containing the inactive sequence arginine-glycine-glutamate.	Carbachol	156-165	protein tyrosine kinase 2	Homo sapiens	71-74
9787266-0	1998	Serotonin and carbachol induced suppression of synaptic responses in rat CA1 hippocampal area: effects of corticosteroid receptor activation in vivo.	Carbachol	14-23	carbonic anhydrase 1	Rattus norvegicus	73-76
9787266-1	1998	Previous studies have shown that corticosteroids affect the changes in membrane potential evoked in CA1 hippocampal neurons by serotonin and the metabolically stable cholinergic analogue carbachol: Low corticosteroid levels induced by steroid administration to adrenalectomized rats or obtained in adrenally intact rats were associated with small transmitter responses.	Carbachol	187-196	carbonic anhydrase 1	Rattus norvegicus	100-103
9667520-3	1998	Amylase and lipase secretion was measured from isolated pancreatic acini in response to CCK-OP (10(-12)-10(-8) M) and carbachol (10(-8)-10(-3) M).	Carbachol	118-127	lipase G, endothelial type	Rattus norvegicus	12-18
9667520-8	1998	Lipase secretion increased in response to CCK-OP in AI compared to PFC and FAC rats but was similar in all three groups in response to carbachol.	Carbachol	135-144	lipase G, endothelial type	Rattus norvegicus	0-6
9636140-4	1998	This report demonstrates that tyrosine phosphorylation of paxillin and FAK elicited by stimulation of muscarinic m3 receptors with the acetylcholine analog carbachol is inhibited by soluble peptides containing the arginine-glycine-aspartate motif (the recognition site for integrins found in adhesion proteins such as fibronectin) but is unaffected by peptides containing the inactive sequence arginine-glycine-glutamate.	Carbachol	156-165	fibronectin 1	Homo sapiens	318-329
9690052-12	1998	Parasympathetic cholinergic influence was studied using 500 mumol/l carbamylcholine, which increased insulin secretion.	Carbachol	68-83	insulin	Homo sapiens	101-108
9636140-6	1998	The response to carbachol is dependent on the presence of fibronectin.	Carbachol	16-25	fibronectin 1	Homo sapiens	58-69
9690869-17	1998	The similar beta3-mRNA levels in ileum of obese and lean mice were associated with indistinguishable responses of carbachol-contracted ileum to a beta3-agonist and similar affinity for beta-antagonists.	Carbachol	114-123	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	12-17
9690869-17	1998	The similar beta3-mRNA levels in ileum of obese and lean mice were associated with indistinguishable responses of carbachol-contracted ileum to a beta3-agonist and similar affinity for beta-antagonists.	Carbachol	114-123	histocompatibility 2, P region beta locus	Mus musculus	144-151
9560440-1	1998	The possibility of the protein kinase C (PKC) pathway being a mechanism underlying the desensitization of carbachol- (CCh-)activated nonselective cationic current (ICCh) was investigated in a study of guinea-pig gastric myocytes.	Carbachol	106-115	Prkca	Cavia porcellus	23-39
9560440-1	1998	The possibility of the protein kinase C (PKC) pathway being a mechanism underlying the desensitization of carbachol- (CCh-)activated nonselective cationic current (ICCh) was investigated in a study of guinea-pig gastric myocytes.	Carbachol	106-115	Prkca	Cavia porcellus	41-44
9622444-0	1998	Carbachol-stimulated Ca2+ increase in single neuroblastoma SH-SY5Y cells: effects of ethanol.	Carbachol	0-9	carbonic anhydrase 2	Homo sapiens	21-24
9622444-1	1998	The effect of ethanol on the characteristics of carbachol-stimulated release of Ca2+ from intracellular Ca2+ stores was studied in single SH-SY5Y cells.	Carbachol	48-57	carbonic anhydrase 2	Homo sapiens	80-83
9622444-1	1998	The effect of ethanol on the characteristics of carbachol-stimulated release of Ca2+ from intracellular Ca2+ stores was studied in single SH-SY5Y cells.	Carbachol	48-57	carbonic anhydrase 2	Homo sapiens	104-107
9622444-2	1998	Stimulation with carbachol, in the absence of extracellular Ca2+, elicited a rapid Ca2+ increase in SH-SY5Y cells peaking within seconds after addition of maximal agonist concentration.	Carbachol	17-26	carbonic anhydrase 2	Homo sapiens	83-86
9622444-5	1998	In a carbachol dose-response analysis, the EC50 for the number of responsive cells and for the peak [Ca2+]i response was lower than that for carbachol-induced inositol 1,4,5-trisphosphate formation by a factor of 5 to 50.	Carbachol	5-14	carbonic anhydrase 2	Homo sapiens	101-104
9751139-5	1998	Phosphorylation of FAK+ was markedly increased by carbachol and LPA.	Carbachol	50-59	protein tyrosine kinase 2	Rattus norvegicus	19-22
9579481-11	1998	Stimulation of a receptor with PTK activity by EGF induced a relaxation in trabecular meshwork and a contraction in ciliary muscle precontracted by carbachol.	Carbachol	148-157	LOC521832	Bos taurus	47-50
9582440-5	1998	Carbachol or nicotine increased expression of transfected FGF-2 gene promoter-luciferase constructs and were more potent than the muscarinic agonist ABMCB.	Carbachol	0-9	fibroblast growth factor 2	Bos taurus	58-63
9604867-7	1998	Thus the carbachol activation of PKC appeared also to be dissociated from the stimulation of insulin release.	Carbachol	9-18	protein kinase C, alpha	Rattus norvegicus	33-36
9604867-8	1998	However, when the activation of several different PKC isozymes was studied, an atypical PKC isozyme, zeta, was found to be translocated by carbachol.	Carbachol	139-148	protein kinase C, alpha	Rattus norvegicus	50-53
9604867-8	1998	However, when the activation of several different PKC isozymes was studied, an atypical PKC isozyme, zeta, was found to be translocated by carbachol.	Carbachol	139-148	protein kinase C, alpha	Rattus norvegicus	88-91
9604867-9	1998	By Western blotting analysis, carbachol selectively translocated the conventional PKC isozymes alpha and beta (the activation of which is dependent on Ca2+ and DAG) from the cytosol to the membrane.	Carbachol	30-39	protein kinase C, alpha	Rattus norvegicus	82-85
9604867-15	1998	The data indicate that carbachol-stimulated insulin release in RINm5F cells is mediated to a large degree by the activation of the atypical PKC isozyme zeta.	Carbachol	23-32	protein kinase C, alpha	Rattus norvegicus	140-143
9488697-7	1998	Thus, VIP and pituitary adenylyl cyclase activating peptide (acting through Gs-coupled pituitary adenylyl cyclase activating peptide-I receptors) were potent stimuli of type I receptor phosphorylation, and remarkably, even slight increases in cAMP concentration induced by carbachol (acting through Gq-coupled muscarinic receptors) or other Ca2+ mobilizing agents were sufficient to cause phosphorylation.	Carbachol	273-282	vasoactive intestinal peptide	Homo sapiens	6-9
9681185-4	1998	Activation of DM1 receptor in S2-DM1-TRPL cells by 100 microM carbamylcholine induced Ca2+ release from an intracellular Ca2+ pool followed by a Gd(3+)-insensitive Ca2+ influx.	Carbachol	62-77	muscarinic Acetylcholine Receptor, A-type	Drosophila melanogaster	14-17
9681185-4	1998	Activation of DM1 receptor in S2-DM1-TRPL cells by 100 microM carbamylcholine induced Ca2+ release from an intracellular Ca2+ pool followed by a Gd(3+)-insensitive Ca2+ influx.	Carbachol	62-77	DM1 protein kinase	Homo sapiens	33-36
9681185-5	1998	Pretreatment of S2-DM1-TRPL cells with 10 microM atropine abolished Gd(3+)-insensitive Ca2+ influx triggered by carbamylcholine, but the response was not blocked by prior incubation with pertussis toxin.	Carbachol	112-127	muscarinic Acetylcholine Receptor, A-type	Drosophila melanogaster	19-22
9553056-2	1998	This cytoskeletal response is rapid, peaking 2 h after thrombin stimulation, and reverses by 50% after 24 h. The thrombin receptor peptide SFLLRNP also induces cell rounding, whereas other G protein-linked receptor agonists such as carbachol, lysophosphatidic acid, or bradykinin fail to do so.	Carbachol	232-241	coagulation factor II, thrombin	Homo sapiens	113-121
9553056-7	1998	Thrombin also leads to a rapid, 2.4-fold increase in 32P incorporation into myosin light chain while carbachol does not.	Carbachol	101-110	coagulation factor II, thrombin	Homo sapiens	0-8
9523591-2	1998	Stimulation with carbachol induced expression of c-fos, fosB, c-jun, junB, and junD.	Carbachol	17-26	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
9523591-2	1998	Stimulation with carbachol induced expression of c-fos, fosB, c-jun, junB, and junD.	Carbachol	17-26	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	56-60
9523591-2	1998	Stimulation with carbachol induced expression of c-fos, fosB, c-jun, junB, and junD.	Carbachol	17-26	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	62-67
9523591-2	1998	Stimulation with carbachol induced expression of c-fos, fosB, c-jun, junB, and junD.	Carbachol	17-26	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-73
9523591-2	1998	Stimulation with carbachol induced expression of c-fos, fosB, c-jun, junB, and junD.	Carbachol	17-26	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-83
9523591-6	1998	Inhibition of protein kinase C with GF109203X suppressed the carbachol-stimulated increase in mRNA levels of c-fos, fosB, and junB by approximately 70% but had only minor effects on the expression of c-jun and junD.	Carbachol	61-70	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-114
9523591-6	1998	Inhibition of protein kinase C with GF109203X suppressed the carbachol-stimulated increase in mRNA levels of c-fos, fosB, and junB by approximately 70% but had only minor effects on the expression of c-jun and junD.	Carbachol	61-70	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-120
9523591-6	1998	Inhibition of protein kinase C with GF109203X suppressed the carbachol-stimulated increase in mRNA levels of c-fos, fosB, and junB by approximately 70% but had only minor effects on the expression of c-jun and junD.	Carbachol	61-70	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	126-130
9523591-6	1998	Inhibition of protein kinase C with GF109203X suppressed the carbachol-stimulated increase in mRNA levels of c-fos, fosB, and junB by approximately 70% but had only minor effects on the expression of c-jun and junD.	Carbachol	61-70	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	210-214
9523591-7	1998	On the other hand, preincubation with KN-62 attenuated the carbachol-induced increase in c-jun and junD expression by 70% but had no effect on c-fos, fosB, and junB mRNA levels.	Carbachol	59-68	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-94
9523591-7	1998	On the other hand, preincubation with KN-62 attenuated the carbachol-induced increase in c-jun and junD expression by 70% but had no effect on c-fos, fosB, and junB mRNA levels.	Carbachol	59-68	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-103
9523591-8	1998	Simultaneous inhibition of both protein kinase C and Ca2+/calmodulin-dependent kinase II completely abolished the carbachol-stimulated expression of c-jun and junD, but c-fos, fosB, and junB were still expressed to a certain extent under this condition.	Carbachol	114-123	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-154
9523591-8	1998	Simultaneous inhibition of both protein kinase C and Ca2+/calmodulin-dependent kinase II completely abolished the carbachol-stimulated expression of c-jun and junD, but c-fos, fosB, and junB were still expressed to a certain extent under this condition.	Carbachol	114-123	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-163
9523591-8	1998	Simultaneous inhibition of both protein kinase C and Ca2+/calmodulin-dependent kinase II completely abolished the carbachol-stimulated expression of c-jun and junD, but c-fos, fosB, and junB were still expressed to a certain extent under this condition.	Carbachol	114-123	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	169-174
9523591-8	1998	Simultaneous inhibition of both protein kinase C and Ca2+/calmodulin-dependent kinase II completely abolished the carbachol-stimulated expression of c-jun and junD, but c-fos, fosB, and junB were still expressed to a certain extent under this condition.	Carbachol	114-123	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	176-180
9523591-8	1998	Simultaneous inhibition of both protein kinase C and Ca2+/calmodulin-dependent kinase II completely abolished the carbachol-stimulated expression of c-jun and junD, but c-fos, fosB, and junB were still expressed to a certain extent under this condition.	Carbachol	114-123	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	186-190
9514902-5	1998	Concentrations of carbachol and xanomeline producing maximal effects on APPs release reduced the secretion of A beta by 28 and 46%, respectively.	Carbachol	18-27	cathepsin B	Homo sapiens	72-76
9514902-5	1998	Concentrations of carbachol and xanomeline producing maximal effects on APPs release reduced the secretion of A beta by 28 and 46%, respectively.	Carbachol	18-27	amyloid beta precursor protein	Homo sapiens	110-116
9478991-7	1998	The rates of both internalization and down-regulation of hm2 receptors in the presence of 10(-6) M or lower concentrations of carbamylcholine were markedly increased by coexpression of GRK2.	Carbachol	126-141	cholinergic receptor muscarinic 2	Homo sapiens	57-60
9507142-3	1998	Reversible acetylcholinesterase (AChE) inhibitors typically caused large transient increases in firing that decayed more slowly than responses to carbachol.	Carbachol	146-155	acetylcholinesterase	Rattus norvegicus	33-37
9498810-2	1998	When stably expressed in HEK293 cells, hTrp3 formed ion channels that were active under resting conditions but could be further stimulated by carbachol or ATP via endogenous muscarinic or purinergic receptors, respectively.	Carbachol	142-151	transient receptor potential cation channel subfamily C member 3	Homo sapiens	39-44
9514311-3	1998	Carbachol-stimulated fosB and junB expression was elevated in ethanol-exposed cells compared with control cells.	Carbachol	0-9	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-25
9514311-3	1998	Carbachol-stimulated fosB and junB expression was elevated in ethanol-exposed cells compared with control cells.	Carbachol	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-34
9514311-5	1998	Preincubation with muscarinic antagonists or protein kinase C inhibitor demonstrated that the carbachol-stimulated increase in fosB and junB mRNA levels was primarily mediated via M1 receptors and dependent on the activity of protein kinase C in both control and ethanol-exposed cells.	Carbachol	94-103	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	127-131
9514311-5	1998	Preincubation with muscarinic antagonists or protein kinase C inhibitor demonstrated that the carbachol-stimulated increase in fosB and junB mRNA levels was primarily mediated via M1 receptors and dependent on the activity of protein kinase C in both control and ethanol-exposed cells.	Carbachol	94-103	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-140
9635156-1	1998	We examined the effects of the muscarinic agonist carbachol on ion secretion induced by substance P (SP) in piglet jejunal tissues mounted in Ussing chambers.	Carbachol	50-59	tachykinin precursor 1	Homo sapiens	88-99
9466430-1	1998	We investigated the effects of the cholinergic agonist carbachol (25 microM) on the synaptic potentials recorded extracellularly and intracellularly from the CA3 area of immature hippocampal slices of the rat (postnatal days 10-20).	Carbachol	55-64	carbonic anhydrase 3	Rattus norvegicus	158-161
9490877-12	1998	Tissue incubation with carbachol or VIP significantly potentiated delta Isc induced by VIP and carbachol, respectively, indicating cross-potentiation.	Carbachol	23-32	VIP peptides	Cavia porcellus	87-90
9490877-12	1998	Tissue incubation with carbachol or VIP significantly potentiated delta Isc induced by VIP and carbachol, respectively, indicating cross-potentiation.	Carbachol	95-104	VIP peptides	Cavia porcellus	36-39
9592059-6	1998	Carbachol stimulated 2DG uptake in both G(q alpha) and GLUT1-transfected cells.	Carbachol	0-9	solute carrier family 2 member 1	Homo sapiens	55-60
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	103-112	promotilin	Oryctolagus cuniculus	15-22
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	103-112	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	103-112	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	103-112	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	114-117	promotilin	Oryctolagus cuniculus	15-22
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	114-117	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	114-117	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	114-117	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	163-166	promotilin	Oryctolagus cuniculus	15-22
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	163-166	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	163-166	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	163-166	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	163-166	promotilin	Oryctolagus cuniculus	15-22
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	163-166	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	163-166	promotilin	Oryctolagus cuniculus	56-63
9530149-2	1998	Stimulation of motilin receptors by exogenously applied motilin (1 nM) resulted in a large increase in carbachol (CCh)-induced atropine-sensitive cation current (ICCh) at threshold concentrations of CCh (0.3-1 microM) at 30 degrees C. This potentiation was abolished in the presence of a specific blocker of motilin receptor (GM109) and was attenuated with increased concentrations of either motilin or CCh, being virtually absent with maximally effective concentrations of these agonists.	Carbachol	163-166	promotilin	Oryctolagus cuniculus	56-63
9484239-6	1998	In the SH-SY5Y cells, both the basal and the carbachol-stimulated release of the amyloid precursor protein were blocked by batimastat.	Carbachol	45-54	amyloid beta precursor protein	Homo sapiens	81-106
9478991-7	1998	The rates of both internalization and down-regulation of hm2 receptors in the presence of 10(-6) M or lower concentrations of carbamylcholine were markedly increased by coexpression of GRK2.	Carbachol	126-141	G protein-coupled receptor kinase 2	Homo sapiens	185-189
9634927-5	1998	For example, 24 h treatment of acinar cells with IL-6 or IFN-gamma did not alter basal or carbachol-stimulated protein (beta-hexosaminidase) secretion, whereas a combination of IL-1 alpha and IL-1 beta decreased carbachol-stimulated beta-hexosaminidase secretion by 80%.	Carbachol	212-221	interleukin 1 alpha	Mus musculus	177-187
9634927-5	1998	For example, 24 h treatment of acinar cells with IL-6 or IFN-gamma did not alter basal or carbachol-stimulated protein (beta-hexosaminidase) secretion, whereas a combination of IL-1 alpha and IL-1 beta decreased carbachol-stimulated beta-hexosaminidase secretion by 80%.	Carbachol	212-221	interleukin 1 beta	Mus musculus	192-201
9458722-12	1998	Finally, the effect of the cytosolic phospholipase A2 inhibitor arachidonyltrifluoromethyl ketone (AACOCF3) on the carbachol-induced short-circuit current (Isc) response was determined.	Carbachol	115-124	phospholipase A2 group IVA	Homo sapiens	27-53
9492905-1	1998	The effects of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and carbachol on CA1 and dentate gyrus action potentials were studied in hippocampus slices in premature, follicular and luteal phase rats.	Carbachol	77-86	carbonic anhydrase 1	Rattus norvegicus	90-93
9458783-0	1998	Distinct effects of tetragastrin, histamine, and CCh on rat gastric mucin synthesis and contribution of NO.	Carbachol	49-52	solute carrier family 13 member 2	Rattus norvegicus	68-73
9458783-1	1998	Although gastrin, histamine, and carbachol (CCh) accelerate gastric mucin metabolism, information about their target cells of mucin production is lacking.	Carbachol	33-42	solute carrier family 13 member 2	Rattus norvegicus	68-73
9458783-1	1998	Although gastrin, histamine, and carbachol (CCh) accelerate gastric mucin metabolism, information about their target cells of mucin production is lacking.	Carbachol	44-47	solute carrier family 13 member 2	Rattus norvegicus	68-73
9871443-6	1998	In the present study, it will be shown that the co-application of NMDA and carbachol synergistically increases the release of [3H]-DA and that this effect is reduced by mepacrine or 4-bromophenacylbromide (10(-7) M), two inhibitors of PLA2.	Carbachol	75-84	phospholipase A2 group IB	Homo sapiens	235-239
9458783-6	1998	Both histamine and CCh dose dependently increased 3H- and 14C-labeled corpus mucin.	Carbachol	19-22	solute carrier family 13 member 2	Rattus norvegicus	77-82
9458783-7	1998	Only CCh stimulated antral mucin biosynthesis.	Carbachol	5-8	solute carrier family 13 member 2	Rattus norvegicus	27-32
9468094-12	1998	In this preparation carbachol (10(-4) M) and neuromedin C (10(-9) M) significantly stimulated gastrin release from 2.6 +/- 0.4 to 4.9 +/- 0.3 and 8.5 +/- 0.9% of the total cellular content, respectively, while GABA (10(-10)-10(-3) M) changed neither basal nor carbachol- and neuromedin C-stimulated gastrin release.	Carbachol	20-29	gastrin	Rattus norvegicus	94-101
9492905-3	1998	The amplitude of CA1 population spike (POPSP) was reduced by allopregnanolone (-38 +/- 3%) and carbachol (-21 +/- 4%) in the luteal phase slices.	Carbachol	95-104	carbonic anhydrase 1	Rattus norvegicus	17-20
9492905-5	1998	The inhibition caused by allopregnanolone and the mixture of allopregnanolone and carbachol in CA1 was significantly larger in the luteal phase than in the follicular phase (P = 0.02 and 0.0002).	Carbachol	82-91	carbonic anhydrase 1	Rattus norvegicus	95-98
9852206-5	1998	Stimulation of SH-SY5Y cells with carbachol and KCl shows that noradrenaline and neuropeptide Y are released in the same proportion as stored in the large dense cored vesicles.	Carbachol	34-43	neuropeptide Y	Homo sapiens	81-95
9468094-12	1998	In this preparation carbachol (10(-4) M) and neuromedin C (10(-9) M) significantly stimulated gastrin release from 2.6 +/- 0.4 to 4.9 +/- 0.3 and 8.5 +/- 0.9% of the total cellular content, respectively, while GABA (10(-10)-10(-3) M) changed neither basal nor carbachol- and neuromedin C-stimulated gastrin release.	Carbachol	20-29	gastrin	Rattus norvegicus	299-306
9422356-8	1998	On the other hand, prevention of the carbachol-mediated increase of intracellular free Ca2+ by pretreatment with the cell-permeant Ca2+ chelator BAPTA/AM did attenuate the carbachol-mediated increase in cytosolic CaM (221 +/- 37% of control without BAPTA/AM vs. 136 +/- 13% with BAPTA/AM).	Carbachol	37-46	calmodulin 1	Homo sapiens	213-216
9422356-8	1998	On the other hand, prevention of the carbachol-mediated increase of intracellular free Ca2+ by pretreatment with the cell-permeant Ca2+ chelator BAPTA/AM did attenuate the carbachol-mediated increase in cytosolic CaM (221 +/- 37% of control without BAPTA/AM vs. 136 +/- 13% with BAPTA/AM).	Carbachol	172-181	calmodulin 1	Homo sapiens	213-216
9468094-12	1998	In this preparation carbachol (10(-4) M) and neuromedin C (10(-9) M) significantly stimulated gastrin release from 2.6 +/- 0.4 to 4.9 +/- 0.3 and 8.5 +/- 0.9% of the total cellular content, respectively, while GABA (10(-10)-10(-3) M) changed neither basal nor carbachol- and neuromedin C-stimulated gastrin release.	Carbachol	260-269	gastrin	Rattus norvegicus	94-101
9422356-14	1998	These data demonstrate that release of Ca2+ from the intracellular store is important for the carbachol-mediated redistribution of CaM in human neuroblastoma SK-N-SH cells.	Carbachol	94-103	calmodulin 1	Homo sapiens	131-134
9510054-3	1998	In the present study, we examined the consequences of steroid modulation of these post-synaptic membrane effects and/or possible pre-synaptic effects by 5HT and CCh for the excitability in the CA1 area, using extracellular field potential or intracellular recordings from individual pyramidal neurons.	Carbachol	161-164	carbonic anhydrase 1	Rattus norvegicus	193-196
9481674-8	1998	Carbachol induced a biphasic contraction: an initial rapid increase in force (peak 1) followed by a partial relaxation and a second delayed increase in force (peak 2).	Carbachol	0-9	pseudopodium-enriched atypical kinase 1	Cavia porcellus	78-84
9459569-4	1998	Furthermore, 5-HT-induced contraction of the rat fundus (5-HT2B) and 5-HT-induced relaxation of the rabbit aorta in the presence of ketanserin (5-HT1) and carbachol-induced contraction of the guinea-pig ileum (muscarinic M3) were not affected by gamma-mangostin (5 microM).	Carbachol	155-164	5-hydroxytryptamine receptor 2B	Rattus norvegicus	57-63
9382934-7	1998	NPY caused 50% inhibition of the effect of carbachol.	Carbachol	43-52	neuropeptide Y	Homo sapiens	0-3
9382934-8	1998	Measurements of [Ca2+]i showed that NPY inhibited the carbachol-induced rise in [Ca2+]i, which correlates with the reduced activation of basolateral K+ channels.	Carbachol	54-63	neuropeptide Y	Homo sapiens	36-39
9700763-3	1998	PACAP-27 had no effect on basal cells but significantly increased the response to histamine (10(-4) M) at 10(-9) M and to carbachol (10(-4) M) in the presence of ranitidine (10(-4) M) at 10(-7) M and 10(-8) M. PACAP (6-38), an antagonist of PACAP, inhibited the effect of PACAP-27 on carbachol-stimulated cells.	Carbachol	122-131	LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide	Oryctolagus cuniculus	0-5
9700763-3	1998	PACAP-27 had no effect on basal cells but significantly increased the response to histamine (10(-4) M) at 10(-9) M and to carbachol (10(-4) M) in the presence of ranitidine (10(-4) M) at 10(-7) M and 10(-8) M. PACAP (6-38), an antagonist of PACAP, inhibited the effect of PACAP-27 on carbachol-stimulated cells.	Carbachol	284-293	LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide	Oryctolagus cuniculus	0-5
9826910-5	1998	Molecular dynamic simulations of the Drosophila muscarinic receptor are presented in the free, carbamylcholine-bound and NMS-bound forms.	Carbachol	95-110	muscarinic Acetylcholine Receptor, A-type	Drosophila melanogaster	48-67
9435551-4	1997	Of the primary gastric secretagogues, carbachol was the most potent inducer of ERK2 activity.	Carbachol	38-47	mitogen-activated protein kinase 1	Canis lupus familiaris	79-83
11382855-0	1998	c-fos Expression in mesopontine noradrenergic and cholinergic neurons of the cat during carbachol-induced active sleep: a double-labeling study.	Carbachol	88-97	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	0-5
11382855-2	1998	To further examine this hypothesis, we sought to determine the pattern of neuronal activation (via c-fos expression) of catecholaminergic and cholinergic neurons in this region during active sleep induced by the pontine microapplication of carbachol (designated as active sleep-carbachol).	Carbachol	240-249	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	99-104
11382855-4	1998	Compared to control cats, active sleep-carbachol cats exhibited a significantly greater number of Fos-expressing neurons in the dorsolateral region of the pons, which encompasses the locus coeruleus, the lateral pontine reticular formation, the peribrachial nuclei and the latero-dorsal and pedunculo-pontine tegmental nuclei.	Carbachol	39-48	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	98-101
11382855-6	1998	A large number of c-fos-expressing neurons in the active sleep-carbachol cats whose neurotransmitter phenotype was not identified suggests that non-catecholaminergic, non-cholinergic neuronal populations in mesopontine regions are involved in the generation and maintenance of active sleep.	Carbachol	63-72	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	18-23
9510054-0	1998	Serotonin and carbachol induced suppression of synaptic excitability in rat CA1 hippocampal area: effects of corticosteroid receptor activation.	Carbachol	14-23	carbonic anhydrase 1	Rattus norvegicus	76-79
9510054-1	1998	Serotonin (5HT) and the cholinergic analogue carbachol (CCh) act on neurons in the hippocampal CA1 area through pre- and post-synaptic receptors.	Carbachol	45-54	carbonic anhydrase 1	Rattus norvegicus	95-98
9510054-1	1998	Serotonin (5HT) and the cholinergic analogue carbachol (CCh) act on neurons in the hippocampal CA1 area through pre- and post-synaptic receptors.	Carbachol	56-59	carbonic anhydrase 1	Rattus norvegicus	95-98
9510054-5	1998	In slices from adrenally intact rats, both 5HT (3-30 microM) and CCh (1-10 microM) induced a dose-dependent suppression of the synaptic field responses evoked in the CA1 area by stimulation of the Schaffer collaterals.	Carbachol	65-68	carbonic anhydrase 1	Rattus norvegicus	166-169
9459616-3	1997	In fact, on SK-N-SH neuroblastoma cells, IL-1beta can inhibit the Ca++ increase induced by stimulation of acetylcholine receptors with carbachol.	Carbachol	135-144	interleukin 1 beta	Homo sapiens	41-49
9459616-4	1997	In parallel to IL-1beta, the neurotrophic factor CNTF also shows an inhibitory effect on carbachol-stimulated Ca++ increase in CNTFRalpha-expressing SK-N-SH cells.	Carbachol	89-98	ciliary neurotrophic factor	Homo sapiens	49-53
9459616-4	1997	In parallel to IL-1beta, the neurotrophic factor CNTF also shows an inhibitory effect on carbachol-stimulated Ca++ increase in CNTFRalpha-expressing SK-N-SH cells.	Carbachol	89-98	ciliary neurotrophic factor receptor	Homo sapiens	127-137
9418962-2	1997	Activation of this neurotransmitter receptor by the stable acetylcholine analog carbachol (CCh) triggers transducing events, modulating c-fos expression and cellular proliferation.	Carbachol	80-89	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	136-141
9418962-2	1997	Activation of this neurotransmitter receptor by the stable acetylcholine analog carbachol (CCh) triggers transducing events, modulating c-fos expression and cellular proliferation.	Carbachol	91-94	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	136-141
9418962-4	1997	CCh produced a concentration- and time-dependent increase in MAPK activity (predominantly the p42mapk or ERK2) as determined by in-gel MBP kinase assays.	Carbachol	0-3	mitogen activated protein kinase 1	Rattus norvegicus	94-101
9418962-4	1997	CCh produced a concentration- and time-dependent increase in MAPK activity (predominantly the p42mapk or ERK2) as determined by in-gel MBP kinase assays.	Carbachol	0-3	mitogen activated protein kinase 1	Rattus norvegicus	105-109
9418962-4	1997	CCh produced a concentration- and time-dependent increase in MAPK activity (predominantly the p42mapk or ERK2) as determined by in-gel MBP kinase assays.	Carbachol	0-3	myelin basic protein	Rattus norvegicus	135-138
9374490-3	1997	This carbachol effect involves (i) activation of brush border phosphatidylinositol 4,5-bisphosphate-specific phospholipase C (PLC) activity and brush border but not basolateral membrane translocation of PLC-gamma1 (Khurana, S., Kreydiyyeh, S., Aronzon, A., Hoogerwerf, W. A., Rhee, S. G., Donowitz, M., and Cohen, M. E. (1996) Biochem.	Carbachol	5-14	LOC100009319	Oryctolagus cuniculus	109-124
9374490-3	1997	This carbachol effect involves (i) activation of brush border phosphatidylinositol 4,5-bisphosphate-specific phospholipase C (PLC) activity and brush border but not basolateral membrane translocation of PLC-gamma1 (Khurana, S., Kreydiyyeh, S., Aronzon, A., Hoogerwerf, W. A., Rhee, S. G., Donowitz, M., and Cohen, M. E. (1996) Biochem.	Carbachol	5-14	LOC100009319	Oryctolagus cuniculus	126-129
9374490-3	1997	This carbachol effect involves (i) activation of brush border phosphatidylinositol 4,5-bisphosphate-specific phospholipase C (PLC) activity and brush border but not basolateral membrane translocation of PLC-gamma1 (Khurana, S., Kreydiyyeh, S., Aronzon, A., Hoogerwerf, W. A., Rhee, S. G., Donowitz, M., and Cohen, M. E. (1996) Biochem.	Carbachol	5-14	LOC100009319	Oryctolagus cuniculus	203-206
9435551-7	1997	PD-98059, a selective inhibitor of the upstream ERK activator mitogen-activated protein kinase/ERK kinase, dose-dependently inhibited both carbachol- and EGF-stimulated ERK2 activity, with a maximal effect observed between 50 and 100 microM.	Carbachol	139-148	mitogen-activated protein kinase 1	Canis lupus familiaris	169-173
9435551-11	1997	Acute inhibition of the ERKs by PD-98059 led to a small increase in AP uptake and a complete reversal of the acute inhibitory effect of EGF on AP uptake induced by either carbachol or histamine.	Carbachol	171-180	epidermal growth factor	Canis lupus familiaris	136-139
9435551-12	1997	In contrast, exposure of the cells to PD-98059 for 16 h led to a reversal of the chronic stimulatory effect of EGF on AP uptake induced by carbachol.	Carbachol	139-148	epidermal growth factor	Canis lupus familiaris	111-114
9368034-7	1997	Transient expression of mTrp6 in COS.M6 cells by transfection of the full-length mTrp6 cDNA increases Ca2+ entry induced by stimulation of co-transfected M5 muscarinic acetylcholine receptor with carbachol (CCh), as seen by dual wavelength fura 2 fluorescence ratio measurements.	Carbachol	196-205	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	24-29
9368034-7	1997	Transient expression of mTrp6 in COS.M6 cells by transfection of the full-length mTrp6 cDNA increases Ca2+ entry induced by stimulation of co-transfected M5 muscarinic acetylcholine receptor with carbachol (CCh), as seen by dual wavelength fura 2 fluorescence ratio measurements.	Carbachol	196-205	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	81-86
9368034-7	1997	Transient expression of mTrp6 in COS.M6 cells by transfection of the full-length mTrp6 cDNA increases Ca2+ entry induced by stimulation of co-transfected M5 muscarinic acetylcholine receptor with carbachol (CCh), as seen by dual wavelength fura 2 fluorescence ratio measurements.	Carbachol	207-210	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	24-29
9368034-7	1997	Transient expression of mTrp6 in COS.M6 cells by transfection of the full-length mTrp6 cDNA increases Ca2+ entry induced by stimulation of co-transfected M5 muscarinic acetylcholine receptor with carbachol (CCh), as seen by dual wavelength fura 2 fluorescence ratio measurements.	Carbachol	207-210	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	81-86
9348338-1	1997	Exposure of rat hippocampal slices to low concentrations of the muscarinic agonist carbachol (CCh) has been shown to produce a slow onset long-term potentiation (LTP) of reactivity to afferent stimulation in CA1 neurons.	Carbachol	83-92	carbonic anhydrase 1	Rattus norvegicus	208-211
9348338-1	1997	Exposure of rat hippocampal slices to low concentrations of the muscarinic agonist carbachol (CCh) has been shown to produce a slow onset long-term potentiation (LTP) of reactivity to afferent stimulation in CA1 neurons.	Carbachol	94-97	carbonic anhydrase 1	Rattus norvegicus	208-211
9439833-1	1997	The effects of carbamylcholine (CCh) on the gene expression of the neuropeptide vasoactive intestinal polypeptide (VIP) were studied using two human neuroblastoma cell lines.	Carbachol	15-30	vasoactive intestinal peptide	Homo sapiens	115-118
9439833-1	1997	The effects of carbamylcholine (CCh) on the gene expression of the neuropeptide vasoactive intestinal polypeptide (VIP) were studied using two human neuroblastoma cell lines.	Carbachol	32-35	vasoactive intestinal peptide	Homo sapiens	115-118
9439833-3	1997	CCh caused a fast increase in VIP mRNA level in both cell lines which was followed by an increase in VIP immunoreactivity.	Carbachol	0-3	vasoactive intestinal peptide	Homo sapiens	30-33
9439833-3	1997	CCh caused a fast increase in VIP mRNA level in both cell lines which was followed by an increase in VIP immunoreactivity.	Carbachol	0-3	vasoactive intestinal peptide	Homo sapiens	101-104
9439833-8	1997	Experiments with the translational inhibitor, cycloheximide, showed that CCh mediated a direct effect on the VIP gene expression.	Carbachol	73-76	vasoactive intestinal peptide	Homo sapiens	109-112
9439833-11	1997	After CCh induction the concentration of all prepro VIP-derived products increased, and there was a tendency towards a shift to more fully processed VIP.	Carbachol	6-9	vasoactive intestinal peptide	Homo sapiens	52-55
9374680-6	1997	Furthermore, when IL-1 beta-treated islets were exposed to 100 microM carbachol (which activates PLC partially independent of extracellular Ca2+), the effects were still obliterated by IL-1 beta.	Carbachol	70-79	interleukin 1 beta	Homo sapiens	18-27
9374490-11	1997	Carbachol also increases the amount of tyrosine-phosphorylated villin that associates with PLC-gamma1.	Carbachol	0-9	LOC100009319	Oryctolagus cuniculus	91-94
9374490-12	1997	These studies demonstrate that carbachol effects on NaCl absorption are accompanied by an increase in brush border PLC-gamma1 association with villin and an increase in tyrosine phosphorylation of villin.	Carbachol	31-40	LOC100009319	Oryctolagus cuniculus	115-118
9374680-6	1997	Furthermore, when IL-1 beta-treated islets were exposed to 100 microM carbachol (which activates PLC partially independent of extracellular Ca2+), the effects were still obliterated by IL-1 beta.	Carbachol	70-79	interleukin 1 beta	Homo sapiens	185-194
9401759-5	1997	The potency order for the affinity of these agents for muscarinic receptors was carbachol &gt; McN-A-343 &gt;&gt; AHR-602.	Carbachol	80-89	aryl hydrocarbon receptor	Cavia porcellus	114-117
9374719-3	1997	We have investigated phosphorylation of HSP27 in airway smooth muscle in response to the muscarinic agonist carbachol.	Carbachol	108-117	heat shock protein family B (small) member 1	Canis lupus familiaris	40-45
9374719-4	1997	Carbachol increased 32P incorporation into canine tracheal HSP27 and induced a shift in the distribution of charge isoforms on two-dimensional gels to more acidic, phosphorylated forms.	Carbachol	0-9	heat shock protein family B (small) member 1	Canis lupus familiaris	59-64
9374719-7	1997	Recombinant canine HSP27 expressed in Escherichia coli was a substrate for MAPKAP kinase-2 in vitro as well as a substrate for endogenous smooth muscle HSP27 kinase, which was activated by carbachol.	Carbachol	189-198	heat shock protein family B (small) member 1	Canis lupus familiaris	19-24
9374719-7	1997	Recombinant canine HSP27 expressed in Escherichia coli was a substrate for MAPKAP kinase-2 in vitro as well as a substrate for endogenous smooth muscle HSP27 kinase, which was activated by carbachol.	Carbachol	189-198	heat shock protein family B (small) member 1	Canis lupus familiaris	152-157
9401759-7	1997	In the presence of 2.2 mM extracellular Ca2+, McN-A-343 and AHR-602 induced contraction corresponding to 79 and 85%, respectively, of the maximal contraction to 0.1 mM carbachol.	Carbachol	168-177	aryl hydrocarbon receptor	Cavia porcellus	60-63
9401759-12	1997	Application of McN-A-343 or AHR-602 inhibited the carbachol-induced contraction in Ca(2+)-free solution, and this inhibition was surmounted by a higher concentration of carbachol.	Carbachol	50-59	aryl hydrocarbon receptor	Cavia porcellus	28-31
9401759-12	1997	Application of McN-A-343 or AHR-602 inhibited the carbachol-induced contraction in Ca(2+)-free solution, and this inhibition was surmounted by a higher concentration of carbachol.	Carbachol	169-178	aryl hydrocarbon receptor	Cavia porcellus	28-31
9375582-0	1997	Actions of C-type natriuretic peptide and sodium nitroprusside on carbachol-stimulated inositol phosphate formation and contraction in ciliary and iris sphincter smooth muscles.	Carbachol	66-75	natriuretic peptide C	Bos taurus	11-37
9349533-7	1997	This segregation of InsP3R types explains a previous observation, showing that the muscarinic agonist carbachol causes the reduction or "down-regulation" of type I but not type II InsP3Rs.	Carbachol	102-111	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	20-26
9349535-5	1997	Incubation with carbachol, a cholinergic agonist known to activate PKC and increase intracellular calcium levels via phosphatidylinositol breakdown, also down-regulated CRF-R1 mRNA levels.	Carbachol	16-25	corticotropin releasing hormone receptor 1	Mus musculus	169-175
9356412-5	1997	In extracellular recordings, a regularly spaced bursting pattern of field potentials was observed in both CA3 and CA1 subfields in the presence of carbachol.	Carbachol	147-156	carbonic anhydrase 3	Rattus norvegicus	106-109
9356412-5	1997	In extracellular recordings, a regularly spaced bursting pattern of field potentials was observed in both CA3 and CA1 subfields in the presence of carbachol.	Carbachol	147-156	carbonic anhydrase 1	Rattus norvegicus	114-117
9356412-10	1997	In the presence of carbachol, individual CA3 pyramidal cells exhibited a slow, rhythmic intrinsic oscillation that was not blocked by DNQX and that was enhanced by membrane hyperpolarization.	Carbachol	19-28	carbonic anhydrase 3	Rattus norvegicus	41-44
9300429-6	1997	Carbachol activation of parafascicular neurons also induced the synthesis of c-Fos-like immunoreactive proteins in the pallidal neurons.	Carbachol	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	77-82
9362243-6	1997	Phenylephrine or carbachol inhibited Kv4 currents only when coexpressed, respectively, with alpha1C-adrenergic or M1 muscarinic receptors (this inhibition was also prevented by chelerythrine).	Carbachol	17-26	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	37-40
9430424-9	1997	The maximal tension, frequency and dose-dependency of carbachol-induced contractions were not influenced by motilin (pEC50, carbachol: 6.48 +/- 0.06 (control), 6.49 +/- 0.07 (motilin)).	Carbachol	54-63	promotilin	Oryctolagus cuniculus	175-182
9362309-5	1997	Therefore, the present study tested the hypothesis that cAMP and PKA within the mPRF modulate the carbachol-induced REM sleep-like state.	Carbachol	98-107	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	80-84
9375582-10	1997	In bovine Sph, CNP increased cGMP accumulation in a time- and dose-dependent manner and dose dependently inhibited CCh-induced IP3 production and contraction.	Carbachol	115-118	natriuretic peptide C	Bos taurus	15-18
9375582-12	1997	C-type natriuretic peptide attenuated CCh-induced contraction in CM isolated from monkey and human, but it had no influence on this response in CM isolated from cows, cats, and dogs.	Carbachol	38-41	natriuretic peptide C	Homo sapiens	0-26
9375582-14	1997	Agents that strongly increase intracellular cGMP levels, including SNP and CNP, produce significant inhibition of CCh-induced IP3 production and contraction.	Carbachol	114-117	natriuretic peptide C	Bos taurus	75-78
9324135-5	1997	Centrally administered neurotensin inhibits basal, pentagastrin-, carbachol-, and 2-deoxy-D-glucose-induced but not histamine-induced gastric acid secretion.	Carbachol	66-75	neurotensin	Rattus norvegicus	23-34
9406932-0	1997	AP-1 and NF-kappaB stimulated by carbachol in human neuroblastoma SH-SY5Y cells are differentially sensitive to inhibition by lithium.	Carbachol	33-42	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
9406932-0	1997	AP-1 and NF-kappaB stimulated by carbachol in human neuroblastoma SH-SY5Y cells are differentially sensitive to inhibition by lithium.	Carbachol	33-42	nuclear factor kappa B subunit 1	Homo sapiens	9-18
9406932-2	1997	The cholinergic agonist carbachol concentration-dependently stimulated AP-1 (EC50 = 2 microM) and NF-kappaB (EC50 = 14 microM).	Carbachol	24-33	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-75
9406932-2	1997	The cholinergic agonist carbachol concentration-dependently stimulated AP-1 (EC50 = 2 microM) and NF-kappaB (EC50 = 14 microM).	Carbachol	24-33	nuclear factor kappa B subunit 1	Homo sapiens	98-107
9406932-3	1997	Pretreatment for 24 h with a therapeutically relevant concentration of lithium (1 mM) substantially inhibited (30-35%) carbachol-stimulation AP-1 but not NF-kappaB.	Carbachol	119-128	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	141-145
9406932-4	1997	Inhibition of carbachol-induced AP-1 was directly related to the concentration of lithium (1-20 mM).	Carbachol	14-23	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-36
9406932-5	1997	Besides being differentially sensitive to inhibition by lithium, activation of AP-1 and NF-kappaB demonstrated different carbachol EC50 concentrations, and carbachol-induced activation of AP-1, but not NF-kappaB, was inhibited by treating cells with Ni2+, which blocks receptor-mediated calcium influx.	Carbachol	121-130	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-83
9406932-5	1997	Besides being differentially sensitive to inhibition by lithium, activation of AP-1 and NF-kappaB demonstrated different carbachol EC50 concentrations, and carbachol-induced activation of AP-1, but not NF-kappaB, was inhibited by treating cells with Ni2+, which blocks receptor-mediated calcium influx.	Carbachol	121-130	nuclear factor kappa B subunit 1	Homo sapiens	88-97
9406932-5	1997	Besides being differentially sensitive to inhibition by lithium, activation of AP-1 and NF-kappaB demonstrated different carbachol EC50 concentrations, and carbachol-induced activation of AP-1, but not NF-kappaB, was inhibited by treating cells with Ni2+, which blocks receptor-mediated calcium influx.	Carbachol	156-165	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	188-192
9406932-5	1997	Besides being differentially sensitive to inhibition by lithium, activation of AP-1 and NF-kappaB demonstrated different carbachol EC50 concentrations, and carbachol-induced activation of AP-1, but not NF-kappaB, was inhibited by treating cells with Ni2+, which blocks receptor-mediated calcium influx.	Carbachol	156-165	nuclear factor kappa B subunit 1	Homo sapiens	202-211
9352075-3	1997	In contrast, carbachol (CCH) and A23187 decreased CREB phosphorylation, but CCH did not decrease it in the absence of extracellular Ca2+.	Carbachol	13-22	cAMP responsive element binding protein 1	Homo sapiens	50-54
9352075-3	1997	In contrast, carbachol (CCH) and A23187 decreased CREB phosphorylation, but CCH did not decrease it in the absence of extracellular Ca2+.	Carbachol	24-27	cAMP responsive element binding protein 1	Homo sapiens	50-54
9487089-4	1997	administration of carbachol (10(-9) and 10(-8) mol/kg) produced decrease in arterial plasma ACE activity in dose-dependent manner (from 40 to 20 nmol/ml.min) and diminution of lung ACE activity (on 18%).	Carbachol	18-27	angiotensin I converting enzyme	Rattus norvegicus	92-95
9487089-4	1997	administration of carbachol (10(-9) and 10(-8) mol/kg) produced decrease in arterial plasma ACE activity in dose-dependent manner (from 40 to 20 nmol/ml.min) and diminution of lung ACE activity (on 18%).	Carbachol	18-27	angiotensin I converting enzyme	Rattus norvegicus	181-184
9487089-5	1997	It is suggested that carbachol produces an inactivation and inhibition of ACE secretion by lung and lung ACE biosynthesis in sympathetic overactivity rats.	Carbachol	21-30	angiotensin I converting enzyme	Rattus norvegicus	74-77
9487089-5	1997	It is suggested that carbachol produces an inactivation and inhibition of ACE secretion by lung and lung ACE biosynthesis in sympathetic overactivity rats.	Carbachol	21-30	angiotensin I converting enzyme	Rattus norvegicus	105-108
9309207-0	1997	A9 fibroblasts transfected with the m3 muscarinic receptor clone express a Ca2+ channel activated by carbachol, GTP and GDP.	Carbachol	101-110	cholinergic receptor muscarinic 3	Homo sapiens	36-58
9376222-5	1997	Both CCh-induced IP3 production and CCh-induced [Ca2+]i mobilization were more potently antagonized by 4-DAMP, an M3 muscarinic receptor antagonist, than by pirenzepine, an M1 receptor antagonist, suggesting that both responses are mediated through the M3 receptor subtype.	Carbachol	5-8	cholinergic receptor muscarinic 3	Homo sapiens	114-136
9376222-5	1997	Both CCh-induced IP3 production and CCh-induced [Ca2+]i mobilization were more potently antagonized by 4-DAMP, an M3 muscarinic receptor antagonist, than by pirenzepine, an M1 receptor antagonist, suggesting that both responses are mediated through the M3 receptor subtype.	Carbachol	36-39	cholinergic receptor muscarinic 3	Homo sapiens	114-136
9322224-3	1997	Stimulation in this region by carbachol produced natriuresis accompanied by a dramatic increase in plasma ANP concentrations and increased content of the peptide in medial basal hypothalamus (MBH), neurohypophysis (NH) and anterior pituitary gland (AP), without alterations in the content of ANP in lungs or atria.	Carbachol	30-39	natriuretic peptide A	Rattus norvegicus	106-109
9277413-6	1997	Carbachol, an analog of acetylcholine, and the neuroendocrine peptides somatostatin and vasoactive intestinal polypeptide (VIP) stimulated increased expression of hITF mRNA within 5 min.	Carbachol	0-9	vasoactive intestinal peptide	Homo sapiens	123-126
9322224-3	1997	Stimulation in this region by carbachol produced natriuresis accompanied by a dramatic increase in plasma ANP concentrations and increased content of the peptide in medial basal hypothalamus (MBH), neurohypophysis (NH) and anterior pituitary gland (AP), without alterations in the content of ANP in lungs or atria.	Carbachol	30-39	natriuretic peptide A	Rattus norvegicus	292-295
9313780-3	1997	Chick heart cells treated with TGF-beta 1 exhibited a decreased sensitivity for carbachol-mediated inhibition of adenylyl cyclase activity compared with control cells.	Carbachol	80-89	transforming growth factor beta 1	Gallus gallus	31-41
9252389-4	1997	Using NIH 3T3 cells expressing G protein-coupled m1 acetylcholine receptors as an experimental model, we have recently shown that the cholinergic agonist carbachol, but not platelet-derived growth factor, potently elevates JNK activity.	Carbachol	154-163	mitogen-activated protein kinase 8	Mus musculus	223-226
9252389-5	1997	Consistent with these findings, carbachol, but not platelet-derived growth factor, increased the activity of a c-jun promoter-driven reporter gene (for chloramphenicol acetyltransferase).	Carbachol	32-41	jun proto-oncogene	Mus musculus	111-116
9252389-10	1997	Furthermore, cotransfection with MEF2C and MEF2D cDNAs potently enhanced the activity of the c-jun promoter in response to carbachol, and stimulation of m1 receptors, but not direct JNK activation, induced expression of a MEF2-responsive plasmid.	Carbachol	123-132	myocyte enhancer factor 2C	Mus musculus	33-38
9252389-10	1997	Furthermore, cotransfection with MEF2C and MEF2D cDNAs potently enhanced the activity of the c-jun promoter in response to carbachol, and stimulation of m1 receptors, but not direct JNK activation, induced expression of a MEF2-responsive plasmid.	Carbachol	123-132	myocyte enhancer factor 2D	Mus musculus	43-48
9252389-10	1997	Furthermore, cotransfection with MEF2C and MEF2D cDNAs potently enhanced the activity of the c-jun promoter in response to carbachol, and stimulation of m1 receptors, but not direct JNK activation, induced expression of a MEF2-responsive plasmid.	Carbachol	123-132	jun proto-oncogene	Mus musculus	93-98
9252389-10	1997	Furthermore, cotransfection with MEF2C and MEF2D cDNAs potently enhanced the activity of the c-jun promoter in response to carbachol, and stimulation of m1 receptors, but not direct JNK activation, induced expression of a MEF2-responsive plasmid.	Carbachol	123-132	myocyte enhancer factor 2C	Mus musculus	33-37
9258410-9	1997	Treatment with SOD and tiron potentiated carbachol stimulated relaxation in ITA and SV.	Carbachol	41-50	superoxide dismutase 1	Homo sapiens	15-18
9277413-6	1997	Carbachol, an analog of acetylcholine, and the neuroendocrine peptides somatostatin and vasoactive intestinal polypeptide (VIP) stimulated increased expression of hITF mRNA within 5 min.	Carbachol	0-9	trefoil factor 3	Homo sapiens	163-167
9277413-7	1997	These same factors stimulated parallel secretion of the hITF peptide, with maximal stimulation observed at concentrations ranging from 10(-6) M (carbachol and somatostatin) to 10(-7) M (VIP).	Carbachol	145-154	trefoil factor 3	Homo sapiens	56-60
9277413-8	1997	Expression and secretion of hITF in response to carbachol, VIP, and somatostatin was independent of production of apomucin.	Carbachol	48-57	trefoil factor 3	Homo sapiens	28-32
9211814-4	1997	The magnitudes of the peak and plateau of [Ca2+]i transients induced by carbachol (CCH, 10(-6) mol/l) were greatly enhanced by an acidic pHi and nearly abolished by an alkaline pHi.	Carbachol	72-81	glucose-6-phosphate isomerase	Homo sapiens	137-140
9221776-11	1997	In association with the enhancement of spike backpropagation, CCh increased the amplitude and duration of the train-evoked [Ca2+]i changes.	Carbachol	62-65	carbonic anhydrase 2	Rattus norvegicus	124-127
9221776-12	1997	These effects of CCh on dendritic spike potentials and associated [Ca2+]i changes may be important in modulating synaptic integration and plasticity in these neurons.	Carbachol	17-20	carbonic anhydrase 2	Rattus norvegicus	67-70
9211926-3	1997	In this report, using a detergent-free method for isolation of sarcolemmal caveolae from primary cultures of adult rat ventricular myocytes, we demonstrated that the muscarinic cholinergic agonist carbachol promotes the translocation of mAchR into low density gradient fractions containing most myocyte caveolin-3 and eNOS.	Carbachol	197-206	caveolin 3	Rattus norvegicus	303-313
9211926-3	1997	In this report, using a detergent-free method for isolation of sarcolemmal caveolae from primary cultures of adult rat ventricular myocytes, we demonstrated that the muscarinic cholinergic agonist carbachol promotes the translocation of mAchR into low density gradient fractions containing most myocyte caveolin-3 and eNOS.	Carbachol	197-206	nitric oxide synthase 3	Rattus norvegicus	318-322
9211799-0	1997	Effects of myosin light chain kinase inhibitors on carbachol-activated nonselective cationic current in guinea-pig gastric myocytes.	Carbachol	51-60	myosin light chain kinase, smooth muscle	Cavia porcellus	11-36
9211814-4	1997	The magnitudes of the peak and plateau of [Ca2+]i transients induced by carbachol (CCH, 10(-6) mol/l) were greatly enhanced by an acidic pHi and nearly abolished by an alkaline pHi.	Carbachol	72-81	glucose-6-phosphate isomerase	Homo sapiens	177-180
9211814-4	1997	The magnitudes of the peak and plateau of [Ca2+]i transients induced by carbachol (CCH, 10(-6) mol/l) were greatly enhanced by an acidic pHi and nearly abolished by an alkaline pHi.	Carbachol	83-86	glucose-6-phosphate isomerase	Homo sapiens	137-140
9211814-4	1997	The magnitudes of the peak and plateau of [Ca2+]i transients induced by carbachol (CCH, 10(-6) mol/l) were greatly enhanced by an acidic pHi and nearly abolished by an alkaline pHi.	Carbachol	83-86	glucose-6-phosphate isomerase	Homo sapiens	177-180
9211814-6	1997	This effect of pHi was also observed at higher CCH concentrations (10(-4 )and 10(-5) mol/l), at which the inhibitory effect of an alkaline pHi was more pronounced than the stimulatory effect of an acidic pHi.	Carbachol	47-50	glucose-6-phosphate isomerase	Homo sapiens	15-18
9211814-6	1997	This effect of pHi was also observed at higher CCH concentrations (10(-4 )and 10(-5) mol/l), at which the inhibitory effect of an alkaline pHi was more pronounced than the stimulatory effect of an acidic pHi.	Carbachol	47-50	glucose-6-phosphate isomerase	Homo sapiens	139-142
9211814-6	1997	This effect of pHi was also observed at higher CCH concentrations (10(-4 )and 10(-5) mol/l), at which the inhibitory effect of an alkaline pHi was more pronounced than the stimulatory effect of an acidic pHi.	Carbachol	47-50	glucose-6-phosphate isomerase	Homo sapiens	139-142
9211814-7	1997	An acidic pHi shifted the CCH concentration/response curve to the left, whereas an alkaline pHi led to a rightward shift.	Carbachol	26-29	glucose-6-phosphate isomerase	Homo sapiens	10-13
9211814-10	1997	The InsP3 increase induced by CCH was unaltered at an acidic pHi, but was augmented at an alkaline pHi.	Carbachol	30-33	glucose-6-phosphate isomerase	Homo sapiens	61-64
9211814-10	1997	The InsP3 increase induced by CCH was unaltered at an acidic pHi, but was augmented at an alkaline pHi.	Carbachol	30-33	glucose-6-phosphate isomerase	Homo sapiens	99-102
9207273-8	1997	IFN-gamma and IL-10 both separately reduced peak forskolin and carbachol-stimulated Isc.	Carbachol	63-72	interferon gamma	Homo sapiens	0-9
9252447-4	1997	Carbachol and bombesin, but not vasoactive intestinal peptide, also activated p70s6k.	Carbachol	0-9	ribosomal protein S6 kinase B1	Rattus norvegicus	78-84
9207273-8	1997	IFN-gamma and IL-10 both separately reduced peak forskolin and carbachol-stimulated Isc.	Carbachol	63-72	interleukin 10	Homo sapiens	14-19
9207273-11	1997	In addition, both IL-10 and IFN-gamma limit carbachol and forskolin-induced increase in Isc.	Carbachol	44-53	interleukin 10	Homo sapiens	18-23
9207273-11	1997	In addition, both IL-10 and IFN-gamma limit carbachol and forskolin-induced increase in Isc.	Carbachol	44-53	interferon gamma	Homo sapiens	28-37
9191080-3	1997	Pre-incubation with muscarinic antagonists or the protein kinase C inhibitor GF109203X demonstrated that, in both control and ethanol-treated cells, carbachol-induced c-fos expression was mediated via muscarinic M1 receptors and to a large extent through protein kinase C. However, phorbol ester-induced c-fos expression was unaffected in ethanol-treated cells.	Carbachol	149-158	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	304-309
9191080-2	1997	Four days of ethanol exposure enhanced carbachol-stimulated c-fos mRNA expression, analyzed with Northern blot, and Fos/AP-1 binding activity, measured with gel mobility super shift assay.	Carbachol	39-48	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-65
9191080-4	1997	Acute exposure to ethanol caused a suppression of both carbachol- and phorbol ester-stimulated c-fos expression.	Carbachol	55-64	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-100
9191080-3	1997	Pre-incubation with muscarinic antagonists or the protein kinase C inhibitor GF109203X demonstrated that, in both control and ethanol-treated cells, carbachol-induced c-fos expression was mediated via muscarinic M1 receptors and to a large extent through protein kinase C. However, phorbol ester-induced c-fos expression was unaffected in ethanol-treated cells.	Carbachol	149-158	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-172
9176219-7	1997	IGF-I, but not GH, attenuated TPN-induced increases in tissue conductance and carbachol-stimulated ion secretion.	Carbachol	78-87	insulin-like growth factor 1	Rattus norvegicus	0-5
9178925-8	1997	Carbachol, secretin, CCK-8 and prostaglandin E2 (PGE2) strongly stimulated mucin secretion, and gastrin I weakly did.	Carbachol	0-9	solute carrier family 13 member 2	Rattus norvegicus	75-80
9228206-4	1997	In PRL-treated islets, the 45Ca2+ content after a 5 min incubation in the presence of G, Leu, Arg and Cch was significantly higher than the control only in islets cultured for 19 days.	Carbachol	102-105	prolactin	Rattus norvegicus	3-6
9131640-5	1997	Carbachol-stimulated CDP-DAG formation required trace amount of Ca2+ and the response was inhibited by NMDA at low but not high extracellular Ca2+ concentrations.	Carbachol	0-9	cut-like homeobox 1	Rattus norvegicus	21-24
9131640-7	1997	The inhibition of carbachol-stimulated CDP-DAG formation was not affected by adding tetrodotoxin or cobalt chloride suggesting the inhibitory effect was not due to releasing of neurotransmitters.	Carbachol	18-27	cut-like homeobox 1	Rattus norvegicus	39-42
9144240-7	1997	PKC-stimulated phosphorylation occurs predominantly on serine residues and can be induced either by direct stimulation of PKC with phorbol-12,13-dibutyrate or by activation of the m1 acetylcholine receptor-signaling pathway with the muscarinic agonist carbachol.	Carbachol	252-261	proline rich transmembrane protein 2	Homo sapiens	0-3
9131640-9	1997	When cortical slices were preincubated with ligands and lithium to allow the build up of CDP-DAG, carbachol stimulated the incorporation of [3H]PtdIns.	Carbachol	98-107	cut-like homeobox 1	Rattus norvegicus	89-92
9142920-9	1997	Moreover, in CFTR(-/-) mice, both forskolin- and carbachol-stimulated peak HCO3- secretions were fourfold less compared with those in CFTR(+/+) littermates (3.7 +/- 0.2 vs. 15.6 +/- 2.1 and 4.7 +/- 0.3 vs. 14.2 +/- 2.5 micromol x cm(-1) x h(-1), respectively; P &lt; 0.01).	Carbachol	49-58	cystic fibrosis transmembrane conductance regulator	Mus musculus	13-17
9142910-5	1997	A-23187, bombesin, substance P, and carbachol increased the MP mRNA level.	Carbachol	36-45	serine peptidase inhibitor, Kazal type 1	Rattus norvegicus	60-62
9151658-8	1997	PKCepsilon was the most responsive to PdBu reaching almost maximal translocation at a PdBu concentration as low as 10(-9) M. The cholinergic agonist, carbachol (10(-5) and 10(-3) M), induced translocation which was transient for PKCdelta, and -mu, but persisted for 10 min for PKCepsilon.	Carbachol	150-159	protein kinase C epsilon	Homo sapiens	0-10
9105698-7	1997	In contrast, in bronchi contracted with carbachol, 1 microM, the concentration-response curve to SCA 40 was monophasic and yielded a pD2 of 6.31 +/- 0.29.	Carbachol	40-49	coiled-coil domain containing 88C	Homo sapiens	97-103
9085978-8	1997	ET-1 (3 x 10(-8) M) induced contractions that were 76 +/- 3% of those induced by carbachol.	Carbachol	81-90	endothelin 1	Homo sapiens	0-4
9085978-10	1997	Similarly, ET-2 (3 x 10(-8) M) induced contractions that were 74 +/- 5% of those induced by carbachol, and KET also reversed this response in a dose-dependent manner.	Carbachol	92-101	endothelin 2	Homo sapiens	11-15
9085978-11	1997	In epithelium-denuded strips, ET-1 induced contractions that were 104 +/- 3% of those induced by carbachol, and KET still reversed this response.	Carbachol	97-106	endothelin 1	Homo sapiens	30-34
9251770-0	1997	Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol.	Carbachol	131-140	renin	Rattus norvegicus	37-42
9105698-19	1997	In bronchi contracted with carbachol, 1 microM, the nature of the interaction between SCA 40 and the beta 2-adrenoceptor agonist, salbutamol, was synergistic.	Carbachol	27-36	coiled-coil domain containing 88C	Homo sapiens	86-92
9105698-19	1997	In bronchi contracted with carbachol, 1 microM, the nature of the interaction between SCA 40 and the beta 2-adrenoceptor agonist, salbutamol, was synergistic.	Carbachol	27-36	adrenoceptor beta 2	Homo sapiens	101-120
9083272-3	1997	We examined the effect of the cholinergic agent carbachol on the activity of the Na-HCO3 cotransporter in primary cultures of the proximal tubule of the rabbit.	Carbachol	48-57	electrogenic sodium bicarbonate cotransporter 1	Oryctolagus cuniculus	81-102
9209957-9	1997	With addition of 100 microM carbamylcholine, the dissociation was expressed as normal secretion of insulin and hypersecretion of IAPP.	Carbachol	28-43	insulin	Homo sapiens	99-106
9209957-9	1997	With addition of 100 microM carbamylcholine, the dissociation was expressed as normal secretion of insulin and hypersecretion of IAPP.	Carbachol	28-43	islet amyloid polypeptide	Homo sapiens	129-133
9173894-4	1997	This was consistent with the observation that carbachol elicited Ca2+ mobilization and PKC-dependent phosphorylation of cytosolic phospholipase A2 (cPLA2; phosphatide sn-2-acylhydrolase, EC 3.1.1.4) as measured by a decrease in electrophoretic mobility.	Carbachol	46-55	phospholipase A2 group IVA	Homo sapiens	120-146
9173894-4	1997	This was consistent with the observation that carbachol elicited Ca2+ mobilization and PKC-dependent phosphorylation of cytosolic phospholipase A2 (cPLA2; phosphatide sn-2-acylhydrolase, EC 3.1.1.4) as measured by a decrease in electrophoretic mobility.	Carbachol	46-55	phospholipase A2 group IVA	Homo sapiens	148-153
9083272-8	1997	Because carbachol activates phospholipase C and protein kinase C, we examined the effect of carbachol in the presence of the phospholipase C inhibitor, U73122, or the PKC inhibitor, calphostin C, or PKC depletion.	Carbachol	8-17	LOC100009319	Oryctolagus cuniculus	28-43
9083272-9	1997	The phospholipase C inhibitor prevented both the effect of carbachol on the cotransporter and on the intracellular Ca.	Carbachol	59-68	LOC100009319	Oryctolagus cuniculus	4-19
9132013-1	1997	The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded using the attenuated total reflectance technique in the presence and absence of carbamylcholine exhibits a complex pattern of positive and negative bands that provides a spectral map of the structural changes that occur in the nAChR upon agonist binding and subsequent desensitization.	Carbachol	177-192	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	47-79
9094163-3	1997	From enzymatic assays, PLA2 and diacylglycerol (DAG) lipase were activated by Cch and respectively inhibited by the PLA2 inhibitors, mepacrine and aristolochic acid, and by the DAG lipase inhibitor, RHC 80267.	Carbachol	78-81	phospholipase A2 group IB	Rattus norvegicus	23-27
9094163-3	1997	From enzymatic assays, PLA2 and diacylglycerol (DAG) lipase were activated by Cch and respectively inhibited by the PLA2 inhibitors, mepacrine and aristolochic acid, and by the DAG lipase inhibitor, RHC 80267.	Carbachol	78-81	phospholipase A2 group IB	Rattus norvegicus	116-120
9094163-8	1997	RHC 80267 and the PLA2 inhibitors separately and partially suppressed Cch-stimulated amylase secretion, with an additive effect observed when the DAG lipase and the PLA2 inhibitors were combined.	Carbachol	70-73	phospholipase A2 group IB	Rattus norvegicus	18-22
9132013-1	1997	The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded using the attenuated total reflectance technique in the presence and absence of carbamylcholine exhibits a complex pattern of positive and negative bands that provides a spectral map of the structural changes that occur in the nAChR upon agonist binding and subsequent desensitization.	Carbachol	177-192	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	81-86
9132013-1	1997	The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded using the attenuated total reflectance technique in the presence and absence of carbamylcholine exhibits a complex pattern of positive and negative bands that provides a spectral map of the structural changes that occur in the nAChR upon agonist binding and subsequent desensitization.	Carbachol	177-192	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	324-329
9073150-0	1997	Effect of carbachol on vascular and luminal release of immunoreactive gastrin from isolated perfused rat duodenum.	Carbachol	10-19	gastrin	Rattus norvegicus	70-77
9130158-8	1997	Somatostatin (1-300 nM), carbamylcholine (0.1-1 microM) and muscarine (0.1-1 microM) each had a dose-dependent inhibitory effect, from a decrease of Ca2+ spike duration and frequency to a complete block of the GHRH-evoked action potentials.	Carbachol	25-40	growth hormone releasing hormone	Rattus norvegicus	210-214
9045727-6	1997	Biochemical assays and focal applications of several agonists (methoxamine, carbachol, glutamate) of membrane receptors to neurotransmitters and peptides (endothelin 1) demonstrated that their ability to trigger regenerative calcium waves depended on phospholipase C activity and inositol phosphate production.	Carbachol	76-85	endothelin 1	Rattus norvegicus	155-167
9175612-5	1997	L-AP4 (IC50 = &gt;300 microM), D-AP4 (IC50 = &gt;100 microM) and L-SOP (IC50 = 199 +/- 6 microM) inhibited 6 microM (S)-AMPA-stimulated 57Co2+ influx, whereas L-CCG-1 (up to 10 microM), 300 microM (RS)-3,5-dihydroxyphenylglycine, 300 microM (+/-)-baclofen and 1 mM carbachol were ineffective.	Carbachol	265-274	DLG associated protein 4	Homo sapiens	31-36
9196397-10	1997	Thus, 17-phenyl PGF2 alpha (1 microM) weakly contracted the ciliary muscle (4.8%), sulprostone (1 microM) the trabecular meshwork (10.1%), 11-deoxy PGE1 (1 microM) and AH13205 (10 microM) elicited relaxations in both tissue precontracted with carbachol (1 microM).	Carbachol	243-252	prostaglandin F synthase 2	Bos taurus	16-20
9049150-0	1997	Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol.	Carbachol	76-85	LOC100508689	Homo sapiens	39-44
9049150-6	1997	Cholera toxin caused a 116-fold increase of intracellular cAMP and strongly stimulated the secretion of both preformed and newly synthesized mucin for more than 20 h. Carbachol only triggered the release of preformed mucin immediately after addition.	Carbachol	167-176	LOC100508689	Homo sapiens	141-146
9038886-2	1997	The present study was designed to investigate activation of PLC-beta isoenzymes by three different PLC-activating agonists that bind to different receptor entities, i.e., cholecystokinin octapeptide (CCK-8), bombesin, and carbachol in rat pancreatic acinar membranes.	Carbachol	222-231	phospholipase C, gamma 1	Rattus norvegicus	60-63
9049150-6	1997	Cholera toxin caused a 116-fold increase of intracellular cAMP and strongly stimulated the secretion of both preformed and newly synthesized mucin for more than 20 h. Carbachol only triggered the release of preformed mucin immediately after addition.	Carbachol	167-176	LOC100508689	Homo sapiens	217-222
9100288-6	1997	Gastrin treatment (5 micrograms.kg-1.h-1) of CR rats restored the gastric acid responses to both histamine and carbachol.	Carbachol	111-120	gastrin	Rattus norvegicus	0-7
9100288-7	1997	These results suggest that CR can selectively decrease the gastric acid responses to both histamine and carbachol by depletion of the endogenous tissue stores of gastrin.	Carbachol	104-113	gastrin	Rattus norvegicus	162-169
9124375-3	1997	Myelin basic protein kinase activities corresponding to ERK1 and ERK2 immunoreactive proteins were activated twofold above the basal level within 5 min by 1 microM carbachol.	Carbachol	164-173	mitogen-activated protein kinase 3	Mus musculus	56-60
9124375-3	1997	Myelin basic protein kinase activities corresponding to ERK1 and ERK2 immunoreactive proteins were activated twofold above the basal level within 5 min by 1 microM carbachol.	Carbachol	164-173	mitogen-activated protein kinase 1	Mus musculus	65-69
9124375-6	1997	Carbachol stimulation increased caldesmon phosphorylation in intact muscle, and purified caldesmon was a substrate for activated murine ERK2 MAP kinase.	Carbachol	0-9	mitogen-activated protein kinase 1	Mus musculus	136-140
9100260-0	1997	Involvement of M2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices.	Carbachol	74-83	carbonic anhydrase 1	Cavia porcellus	107-110
9100260-1	1997	We examined effects of carbachol (CCh), muscarinic receptor agonist, on long-term potentiation (LTP) of field excitatory postsynaptic potential (fEPSP) at Schaffer collateral-CA1 synapse of guinea pig hippocampal slices using extracellular recording technique.	Carbachol	23-32	carbonic anhydrase 1	Cavia porcellus	175-178
9100260-1	1997	We examined effects of carbachol (CCh), muscarinic receptor agonist, on long-term potentiation (LTP) of field excitatory postsynaptic potential (fEPSP) at Schaffer collateral-CA1 synapse of guinea pig hippocampal slices using extracellular recording technique.	Carbachol	34-37	carbonic anhydrase 1	Cavia porcellus	175-178
9100260-6	1997	These results suggest that the induction of LTP at Schaffer collateral-CA1 synapse was enhanced through the activation of M2 receptors by CCh at a lower concentration.	Carbachol	138-141	carbonic anhydrase 1	Cavia porcellus	71-74
9080376-11	1997	Both carbachol and PGF2 alpha potentiated phosphorylation of MLC20 in depolarized tissues.	Carbachol	5-14	myosin light chain 12B	Rattus norvegicus	61-66
9031749-6	1997	However, when either NPY (300 pM-1 microM) or SRIF (300 pM-1 microM) was applied in the presence of the cholinoceptor agonist carbachol (1 microM or 100 microM) they evoked an elevation of [Ca2+]i above that caused by carbachol alone.	Carbachol	126-135	neuropeptide Y	Homo sapiens	21-24
9031749-6	1997	However, when either NPY (300 pM-1 microM) or SRIF (300 pM-1 microM) was applied in the presence of the cholinoceptor agonist carbachol (1 microM or 100 microM) they evoked an elevation of [Ca2+]i above that caused by carbachol alone.	Carbachol	218-227	neuropeptide Y	Homo sapiens	21-24
9031749-9	1997	In the presence of 1 microM or 100 microM carbachol NPY elevated [Ca2+]i with a pEC50 of 7.80 and 7.86 respectively.	Carbachol	42-51	neuropeptide Y	Homo sapiens	52-55
9031749-19	1997	Block of carbachol activation of muscarinic receptors with atropine (1 microM) abolished the elevation of [Ca2+]i by the SRIF and NPY.	Carbachol	9-18	neuropeptide Y	Homo sapiens	130-133
9000425-7	1997	Refilling of internal Ca2+ store(s) in carbachol-treated cells (incubation with Ca2++atropine) induced complete inhibition of divalent cation influx, which was not prevented by treatment with protein kinase inhibitors.	Carbachol	39-48	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	192-206
8995260-7	1997	The predominant role of NHE-1 in carbachol-induced Na+/H+ exchange was established pharmacologically using HOE694, an inhibitor with differential potency toward the individual isoforms.	Carbachol	33-42	solute carrier family 9 member A1	Homo sapiens	24-29
8978749-3	1997	The potentiation effect of arginine on carbachol-induced calcium mobilization was mimicked by either 8-bromo cyclic GMP or sodium nitroprusside.	Carbachol	39-48	5'-nucleotidase, cytosolic II	Homo sapiens	116-119
9038869-7	1997	Both phenylephrine and octreotide decreased the release of motilin stimulated by carbachol in a jejunal segment pretreated and denervated with tetrodotoxin.	Carbachol	81-90	motilin	Canis lupus familiaris	59-66
9038886-6	1997	The order of sensitivity toward inhibition by anti-PLC-beta 1 antibody was CCK-8 &gt; bombesin &gt; carbachol.	Carbachol	100-109	phospholipase C beta 1	Rattus norvegicus	51-61
9038886-7	1997	An opposite order of sensitivity was found for inhibition of PLC activity by anti-PLC-beta 3 antibody (carbachol &gt; bombesin &gt; CCK-8).	Carbachol	103-112	phospholipase C, gamma 1	Rattus norvegicus	61-64
9038886-7	1997	An opposite order of sensitivity was found for inhibition of PLC activity by anti-PLC-beta 3 antibody (carbachol &gt; bombesin &gt; CCK-8).	Carbachol	103-112	phospholipase C beta 3	Rattus norvegicus	82-92
9038886-7	1997	An opposite order of sensitivity was found for inhibition of PLC activity by anti-PLC-beta 3 antibody (carbachol &gt; bombesin &gt; CCK-8).	Carbachol	103-112	cholecystokinin	Rattus norvegicus	132-135
9038886-10	1997	In conclusion, the data of the present study indicate that CCK-8 and carbachol activate PLC-beta 1 and PLC-beta 3, respectively, whereas bombesin activates both PLC-beta 1 and PLC-beta 3.	Carbachol	69-78	phospholipase C beta 1	Rattus norvegicus	88-98
9038886-10	1997	In conclusion, the data of the present study indicate that CCK-8 and carbachol activate PLC-beta 1 and PLC-beta 3, respectively, whereas bombesin activates both PLC-beta 1 and PLC-beta 3.	Carbachol	69-78	phospholipase C beta 3	Rattus norvegicus	103-113
8978749-6	1997	It is suggested that the NO production and subsequent cyclic GMP elevation induced by arginine are responsible for the potentiation of carbachol-induced Ca2+ increase.	Carbachol	135-144	5'-nucleotidase, cytosolic II	Homo sapiens	61-64
9121353-3	1997	Treatment of chick embryos in ovo with carbachol results in decreased levels of mRNA encoding the potassium channel subunits GIRK1 and GIRK4 as well as the m2 receptor.	Carbachol	39-48	Potassium inwardly rectifying channel subfamily J member 3	Gallus gallus	125-130
9121353-3	1997	Treatment of chick embryos in ovo with carbachol results in decreased levels of mRNA encoding the potassium channel subunits GIRK1 and GIRK4 as well as the m2 receptor.	Carbachol	39-48	Potassium inwardly rectifying channel subfamily J member 5	Gallus gallus	135-140
9121362-5	1997	Only the PC3 cells responded to carbachol with an increase in turnover of polyphosphoinositides, and none of the cell lines responded with effects on cAMP metabolism.	Carbachol	32-41	proprotein convertase subtilisin/kexin type 1	Homo sapiens	9-12
9121362-7	1997	Mitogen activated protein kinase (ERK) activity was seen in response to carbachol in PC3 and DU145 but not LnCaP cells.	Carbachol	72-81	mitogen-activated protein kinase 1	Homo sapiens	34-37
9121362-7	1997	Mitogen activated protein kinase (ERK) activity was seen in response to carbachol in PC3 and DU145 but not LnCaP cells.	Carbachol	72-81	proprotein convertase subtilisin/kexin type 1	Homo sapiens	85-88
9247321-1	1997	In rat olfactory bulb membranes, the stimulation of adenylyl cyclase by the cholinergic agonist carbachol (CCh) was markedly inhibited by heparin at concentrations (0.3-10 microM) that had smaller or no effects on the enzyme stimulations elicited by vasoactive intestinal peptide, pituitary adenylate cyclase activating polypeptide (PACAP), 1-isoproterenol and corticotropin releasing hormone.	Carbachol	96-105	adenylate cyclase activating polypeptide 1	Rattus norvegicus	333-338
9503254-3	1997	At high concentrations, the 5-HT1A agonist 8-OH-DPAT attenuated the carbachol-induced stimulation of inositol phosphates (InsPs) production, but this was not blocked by the presence of 5-HT1A antagonists.	Carbachol	68-77	5-hydroxytryptamine receptor 1A	Oryctolagus cuniculus	28-34
9247321-1	1997	In rat olfactory bulb membranes, the stimulation of adenylyl cyclase by the cholinergic agonist carbachol (CCh) was markedly inhibited by heparin at concentrations (0.3-10 microM) that had smaller or no effects on the enzyme stimulations elicited by vasoactive intestinal peptide, pituitary adenylate cyclase activating polypeptide (PACAP), 1-isoproterenol and corticotropin releasing hormone.	Carbachol	107-110	adenylate cyclase activating polypeptide 1	Rattus norvegicus	333-338
9213360-4	1997	Only 4-DAMP inhibited carbachol-induced motilin release in perifused duodenal mucosal cells.	Carbachol	22-31	motilin	Canis lupus familiaris	40-47
8942735-6	1996	Guanylin-stimulated HCO3- secretion was independent of luminal Cl-, inhibited by the Cl- channel blocker 5-nitro-2-(3-phenylpropylamino)-benzoate, and additive to the HCO3- secretory rate stimulated by glucagon and carbachol but not by the tested adenosine 3",5"-cyclic monophosphate (cAMP)-dependent agonists.	Carbachol	215-224	guanylate cyclase activator 2A	Rattus norvegicus	0-8
9037533-0	1996	Carbachol stimulates c-fos expression and proliferation in oligodendrocyte progenitors.	Carbachol	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-26
9037533-2	1996	Using Northern blot analysis we showed that carbachol caused a time and concentration-dependent increase in c-fos mRNA.	Carbachol	44-53	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-113
9037533-5	1996	Down-regulation of PKC by overnight pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) blocked only the phorbol ester-stimulated c-fos accumulation while no effect was observed in the carbachol-induced response.	Carbachol	195-204	proline rich transmembrane protein 2	Homo sapiens	19-22
9037533-6	1996	These results suggested that carbachol stimulated an H-7 sensitive PKC pathway which may be different than that activated by TPA.	Carbachol	29-38	proline rich transmembrane protein 2	Homo sapiens	67-70
9037533-8	1996	Induction of c-fos mRNA by carbachol was dependent on both influx of extracellular Ca2+ and release from intracellular stores, as both EDTA and BAPTA blocked the response.	Carbachol	27-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
8942723-6	1996	RESULTS: In vitro, c-motilin release was stimulated by carbachol but not by p-motilin, and the carbachol-induced c-motilin release was inhibited by atropine.	Carbachol	55-64	motilin	Canis lupus familiaris	21-28
8942723-6	1996	RESULTS: In vitro, c-motilin release was stimulated by carbachol but not by p-motilin, and the carbachol-induced c-motilin release was inhibited by atropine.	Carbachol	95-104	motilin	Canis lupus familiaris	21-28
9008642-4	1997	RESULTS: Pharmacologic agents [Arg8]-vasopressin, carbachol, adenosine triphosphate, substance P, fetal calf serum, and histamine all elicited, to some extent, a biphasic [Ca2+]i transient by releasing Ca2+ from InsP3-sensitive Ca2+ stores.	Carbachol	50-59	carbonic anhydrase 2	Rattus norvegicus	172-175
9008642-4	1997	RESULTS: Pharmacologic agents [Arg8]-vasopressin, carbachol, adenosine triphosphate, substance P, fetal calf serum, and histamine all elicited, to some extent, a biphasic [Ca2+]i transient by releasing Ca2+ from InsP3-sensitive Ca2+ stores.	Carbachol	50-59	carbonic anhydrase 2	Rattus norvegicus	202-205
9008642-4	1997	RESULTS: Pharmacologic agents [Arg8]-vasopressin, carbachol, adenosine triphosphate, substance P, fetal calf serum, and histamine all elicited, to some extent, a biphasic [Ca2+]i transient by releasing Ca2+ from InsP3-sensitive Ca2+ stores.	Carbachol	50-59	carbonic anhydrase 2	Rattus norvegicus	202-205
9051814-3	1996	We report that expression of PS-1 mutation L286V in cultured PC12 cells exaggerates Ca2+ responses to agonists (carbachol and bradykinin) that induce Ca2+ release from ER.	Carbachol	112-121	presenilin 1	Rattus norvegicus	29-33
9117394-9	1996	Finally, the release of [3H]GABA evoked by the combined application of NMDA and carbachol (a treatment known to markedly stimulate arachidonic acid formation) was reduced by inhibitors of phospholipase A2 further indicating that endogenously formed arachidonic acid significantly facilitates the release of GABA in the striatum.	Carbachol	80-89	phospholipase A2 group IB	Rattus norvegicus	188-204
8922737-4	1996	The ETB receptor-selective agonist, sarafotoxin S6c (30 nM) induced large transient contractions (118 +/- 5% Cmax, n = 13; where Cmax is the contraction induced by 10 microM carbachol) of isolated tracheal segments from control mice.	Carbachol	174-183	endothelin receptor type B	Mus musculus	4-7
9019738-12	1996	An acid pHi attenuated, and an alkaline pHi enhanced, carbachol- and thapsigargin-induced [Ca2+]i influx.	Carbachol	54-63	glucose-6-phosphate isomerase	Homo sapiens	8-11
9019738-12	1996	An acid pHi attenuated, and an alkaline pHi enhanced, carbachol- and thapsigargin-induced [Ca2+]i influx.	Carbachol	54-63	glucose-6-phosphate isomerase	Homo sapiens	40-43
8910218-2	1996	The aim of this study was to determine whether the low molecular mass GTPase RhoA or related proteins are involved in carbachol- and high-K(+)-induced contractions in intact intestinal smooth muscle as well as the carbachol-induced increase in Ca2+ sensitivity of the myofilaments in permeabilized preparations.	Carbachol	118-127	transforming protein RhoA	Cavia porcellus	77-81
8910218-2	1996	The aim of this study was to determine whether the low molecular mass GTPase RhoA or related proteins are involved in carbachol- and high-K(+)-induced contractions in intact intestinal smooth muscle as well as the carbachol-induced increase in Ca2+ sensitivity of the myofilaments in permeabilized preparations.	Carbachol	214-223	transforming protein RhoA	Cavia porcellus	77-81
8910218-4	1996	The carbachol-induced increase in the Ca2+ sensitivity of force production in beta-escin-permeabilized intestinal smooth muscle was enhanced in preparations that were loaded with the constitutively active mutant of RhoA, Val14RhoA, and was inhibited by exoenzyme C3 from Clostridium botulinum, which ADP-ribosylates and inactivates small GTPases of the Rho family.	Carbachol	4-13	transforming protein RhoA	Cavia porcellus	215-219
8900438-9	1996	Other cellular effects of CAI included an attenuation of the elevation of intracellular free calcium in response to bombesin and carbachol in PC3 cells and a marked dose-dependent inhibition of prostate-specific antigen secretion in LNCaP cell cultures.	Carbachol	129-138	chromobox 8	Homo sapiens	142-145
8897815-3	1996	Stimulation of insulin release evoked by glucose, phospholipase C activation with carbachol, and protein kinase C activation with phorbol ester were obtained by SIN-1, whereas the response to adenylyl cyclase activation or K(+)-induced depolarization was not affected.	Carbachol	82-91	insulin	Homo sapiens	15-22
8897815-3	1996	Stimulation of insulin release evoked by glucose, phospholipase C activation with carbachol, and protein kinase C activation with phorbol ester were obtained by SIN-1, whereas the response to adenylyl cyclase activation or K(+)-induced depolarization was not affected.	Carbachol	82-91	MAPK associated protein 1	Homo sapiens	161-166
8897836-3	1996	In contrast, at higher supermaximal concentrations of agonists (&gt; 300 pM CCK, &gt; 1 microM CCh), which induce a large "peak-and-plateau" intracellular Ca2+ signal, all cells in the acinus appeared to increase Ca2+ concentration ([Ca2+]) in synchrony.	Carbachol	95-98	cholecystokinin	Rattus norvegicus	76-79
8897883-13	1996	Carbachol, but not EGF or TPA, also activated an unidentified 70-kDa protein kinase as detected with in-gel myelin basic protein (MBP) kinase renaturation assays.	Carbachol	0-9	myelin basic protein	Oryctolagus cuniculus	108-128
8897883-13	1996	Carbachol, but not EGF or TPA, also activated an unidentified 70-kDa protein kinase as detected with in-gel myelin basic protein (MBP) kinase renaturation assays.	Carbachol	0-9	myelin basic protein	Oryctolagus cuniculus	130-133
8831588-7	1996	IL-10 reversed, or markedly attenuated, forskolin- and carbachol-induced net chloride secretion.	Carbachol	55-64	interleukin 10	Rattus norvegicus	0-5
8815874-4	1996	H2O2 and carbachol individually induced dose- and time-dependent increases in AP-1 and NF kappa B.	Carbachol	9-18	nuclear factor kappa B subunit 1	Homo sapiens	87-97
8815874-6	1996	Carbachol"s stimulation of NF kappa B was not inhibited except with a high concentration (300 microM) of H2O2, which was associated with impaired activation of protein kinase C. Lower concentrations of H2O2 (30-300 microM) inhibited carbachol-induced [3H]phosphoinositide hydrolysis, and this inhibition correlated (r = 0.95) with the inhibition of carbachol-induced AP-1.	Carbachol	0-9	nuclear factor kappa B subunit 1	Homo sapiens	27-37
8892103-8	1996	Rp-adenosine-3",5"-cyclic monophosphothioate (Rp-cAMPS; 25 microM), a potent inhibitor of cAMP-dependent protein kinase A (PKA), alone decreased the amplitude of EPSP below baseline values and mimicked the inhibitory effect of DA on the carbachol-induced depression of the EPSP amplitude.	Carbachol	237-246	calmodulin 2, pseudogene 1	Rattus norvegicus	49-54
8863852-6	1996	Furthermore, carbachol pretreatment also enhanced, by approximately 2.5-fold, stimulation of PLC activity on direct activation of G proteins by AIF4- and guanosine-5"-O-(3-thio)-triphosphate in intact and permeabilized cells, respectively.	Carbachol	13-22	itchy E3 ubiquitin protein ligase	Homo sapiens	144-148
8923487-3	1996	Acute exposure to SP inhibits carbamylcholine- or nicotine-stimulated function measured using 86Rb+ efflux assays of human ganglionic (alpha 3 beta 4) nAChR expressed in SH-SY5Y neuroblastoma cells (IC50 approximately 2.3 microM) or of human muscle-type (alpha 1 beta 1 gamma delta) nAChR expressed in TE671/RD clonal cells (IC50 approximately 21 microM).	Carbachol	30-45	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	151-156
8810600-12	1996	Inhaled tryptase (500 ng) also caused airway hyperresponsiveness to aerosolized carbachol 2 h after tryptase challenge.	Carbachol	80-89	tryptase beta-2	Ovis aries	8-16
8810600-12	1996	Inhaled tryptase (500 ng) also caused airway hyperresponsiveness to aerosolized carbachol 2 h after tryptase challenge.	Carbachol	80-89	tryptase beta-2	Ovis aries	100-108
8843722-2	1996	Basolateral EGF inhibited Cl- secretion induced by carbachol or thapsigargin, without blocking the rise in intracellular Ca2+.	Carbachol	51-60	epidermal growth factor	Homo sapiens	12-15
8843732-5	1996	However, stimulation of mouse islets with the protein kinase C (PKC) activator tetradecanoyl phorbol acetate (TPA) or the muscarinic agonist carbachol, which significantly activates an isozyme of PLC distinct from that activated by high glucose, induces a rising and sustained second-phase insulin secretory response.	Carbachol	141-150	insulin	Homo sapiens	290-297
8809056-5	1996	In insulin-secreting beta TC6-F7 cells, the secretagogues glucose and carbachol (at maximally effective concentrations of 15 mM and 0.5 mM respectively) augmented fluid-phase pinocytosis 1.65-fold over the basal rate.	Carbachol	70-79	insulin	Cricetulus griseus	3-10
8809065-7	1996	When neuronally differentiated PC12 cells were stimulated with carbamylcholine or potassium, sPLA2 was released into the medium and reached a maximal approximately 40% release by 15 min.	Carbachol	63-78	phospholipase A2 group IIA	Rattus norvegicus	93-98
8809065-8	1996	Inhibitors specific to type II sPLA2 suppressed catecholamine secretion by PC12 cells which had been activated by carbamylcholine.	Carbachol	114-129	phospholipase A2 group IIA	Rattus norvegicus	31-36
8877593-0	1996	Evidence of systemic neuropeptide Y release after carbachol administration into the posterior hypothalamic nucleus.	Carbachol	50-59	neuropeptide Y	Rattus norvegicus	21-35
8858914-2	1996	Carbachol stimulated luciferase expression in cells transfected with a rat phenylethanolamine N-methyltransferase promoter-luciferase reporter gene construct and also elevated Egr-1 mRNA levels in untransfected cells.	Carbachol	0-9	phenylethanolamine-N-methyltransferase	Rattus norvegicus	75-113
8858914-2	1996	Carbachol stimulated luciferase expression in cells transfected with a rat phenylethanolamine N-methyltransferase promoter-luciferase reporter gene construct and also elevated Egr-1 mRNA levels in untransfected cells.	Carbachol	0-9	early growth response 1	Rattus norvegicus	176-181
8858914-3	1996	Maximum induction of Egr-1 mRNA by carbachol was rapid (0.5 h), whereas by comparison, peak luciferase activity was delayed (6 h).	Carbachol	35-44	early growth response 1	Rattus norvegicus	21-26
8858914-4	1996	In addition, carbachol stimulation of both luciferase and Egr-1 mRNA expression could be completely inhibited by atropine but not hexamethonium.	Carbachol	13-22	early growth response 1	Rattus norvegicus	58-63
8858914-7	1996	These results suggest that carbachol activates the phenylethanolamine N-methyltransferase promotor through stimulation of Egr-1 expression, and are consistent with the potential involvement of Egr-1 in the cholinergic activation of the phenylethanolamine N-methyltransferase gene.	Carbachol	27-36	phenylethanolamine-N-methyltransferase	Rattus norvegicus	51-89
8858914-7	1996	These results suggest that carbachol activates the phenylethanolamine N-methyltransferase promotor through stimulation of Egr-1 expression, and are consistent with the potential involvement of Egr-1 in the cholinergic activation of the phenylethanolamine N-methyltransferase gene.	Carbachol	27-36	early growth response 1	Rattus norvegicus	122-127
8858914-7	1996	These results suggest that carbachol activates the phenylethanolamine N-methyltransferase promotor through stimulation of Egr-1 expression, and are consistent with the potential involvement of Egr-1 in the cholinergic activation of the phenylethanolamine N-methyltransferase gene.	Carbachol	27-36	early growth response 1	Rattus norvegicus	193-198
8858914-7	1996	These results suggest that carbachol activates the phenylethanolamine N-methyltransferase promotor through stimulation of Egr-1 expression, and are consistent with the potential involvement of Egr-1 in the cholinergic activation of the phenylethanolamine N-methyltransferase gene.	Carbachol	27-36	phenylethanolamine-N-methyltransferase	Rattus norvegicus	236-274
8906568-2	1996	Depletion of extracellular Ca2+ abolished the Cch-mediated phospholipase D (PLD) activation, indicating the requirement of Ca2+ influx.	Carbachol	46-49	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	76-79
8718877-8	1996	Photolysis of acetylcholinesterase complexed with the 2-nitrobenzyl derivative of carbamylcholine led to time-dependent inactivation, resulting from carbamylation of acetylcholinesterase, which could be reversed upon dilution, due to decarbamylation.	Carbachol	82-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
8718877-8	1996	Photolysis of acetylcholinesterase complexed with the 2-nitrobenzyl derivative of carbamylcholine led to time-dependent inactivation, resulting from carbamylation of acetylcholinesterase, which could be reversed upon dilution, due to decarbamylation.	Carbachol	82-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	166-186
8770076-2	1996	Perfusion of hearts with carbachol and isoproterenol concurrently for 1.5 min prevented the increase in left ventricular pressure (LVP) found with isoproterenol alone, although isoproterenol-induced changes in total and particulate cAMP levels and soluble and particulate PKA activity were unaffected.	Carbachol	25-34	cathelicidin antimicrobial peptide	Rattus norvegicus	232-236
8770076-3	1996	However, perfusion of hearts with carbachol for 1 min then with isoproterenol and carbachol for 1.5 min abolished the isoproterenol-induced increase in LVP and in total and particulate cAMP levels, although changes in total and particulate PKA activity were only partially attenuated.	Carbachol	34-43	cathelicidin antimicrobial peptide	Rattus norvegicus	185-189
8770076-3	1996	However, perfusion of hearts with carbachol for 1 min then with isoproterenol and carbachol for 1.5 min abolished the isoproterenol-induced increase in LVP and in total and particulate cAMP levels, although changes in total and particulate PKA activity were only partially attenuated.	Carbachol	82-91	cathelicidin antimicrobial peptide	Rattus norvegicus	185-189
21153096-4	1996	From enzymatic assays, phospholipase A(2) and diacylglycerol lipase were activated by carbamylcholine and these activations were inhibited by the phospholipase A(2) inhibitors, mepacrine and aristolochic acid, and by the diacylglycerol lipase inhibitor RHC 80267.	Carbachol	86-101	phospholipase A2 group IB	Rattus norvegicus	23-67
8856671-8	1996	Agents that induce translocation of endogenous FGF-2 to the nucleus (forskolin, carbachol, or angiotensin II) increased the intranuclear accumulation of FGFR1.	Carbachol	80-89	fibroblast growth factor 2	Bos taurus	47-52
8856671-8	1996	Agents that induce translocation of endogenous FGF-2 to the nucleus (forskolin, carbachol, or angiotensin II) increased the intranuclear accumulation of FGFR1.	Carbachol	80-89	fibroblast growth factor receptor 1	Bos taurus	153-158
8692890-6	1996	Carbachol-induced accumulation of inositol phosphates (IP, IP2, IP3, and IP4) was decreased and calcium imaging studies revealed that carbachol-induced release of calcium was severely impaired in neurons pretreated with Abeta.	Carbachol	0-9	amyloid beta precursor protein	Rattus norvegicus	220-225
8692890-6	1996	Carbachol-induced accumulation of inositol phosphates (IP, IP2, IP3, and IP4) was decreased and calcium imaging studies revealed that carbachol-induced release of calcium was severely impaired in neurons pretreated with Abeta.	Carbachol	134-143	amyloid beta precursor protein	Rattus norvegicus	220-225
8692890-8	1996	The effects of Abeta on carbachol-induced GTPase activity and calcium release were attenuated by antioxidants, implicating free radicals in the mechanism whereby Abeta induced uncoupling of muscarinic receptors.	Carbachol	24-33	amyloid beta precursor protein	Rattus norvegicus	15-20
8692890-8	1996	The effects of Abeta on carbachol-induced GTPase activity and calcium release were attenuated by antioxidants, implicating free radicals in the mechanism whereby Abeta induced uncoupling of muscarinic receptors.	Carbachol	24-33	amyloid beta precursor protein	Rattus norvegicus	162-167
8670170-10	1996	Carbachol or PDBu induced cytosol to membrane translocation of PKC alpha.	Carbachol	0-9	protein kinase C alpha	Homo sapiens	63-72
8660365-1	1996	Three sialagogues, isoproterenol (IPR), carbachol, and methoxamine, caused induction of ornithine decarboxylase (ODC) in cultured rat parotid explants.	Carbachol	40-49	ornithine decarboxylase 1	Rattus norvegicus	88-111
8660365-1	1996	Three sialagogues, isoproterenol (IPR), carbachol, and methoxamine, caused induction of ornithine decarboxylase (ODC) in cultured rat parotid explants.	Carbachol	40-49	ornithine decarboxylase 1	Rattus norvegicus	113-116
8762078-7	1996	VIP was a more potent relaxant in tissues that were contracted with carbachol than those contracted with an equi-effective depolarizing concentration of K+.	Carbachol	68-77	VIP peptides	Cavia porcellus	0-3
8670764-6	1996	Supernatants of unstimulated and carbachol-stimulated human lacrimal gland explant cultures were evaluated for secretion of TGF-beta1 and TGF-beta2 by ELISA: RESULTS: TGF-beta1 and TGF-beta2 mRNA expression was found in all human and rabbit lacrimal gland specimens by RT-PCR.	Carbachol	33-42	transforming growth factor beta 1	Homo sapiens	167-176
8670764-10	1996	TGF-beta1 was detected in supernatants of human lacrimal gland explants, and the concentration of TGF-beta1 increased by an average of 280% after carbachol-stimulation (p = 0.004).	Carbachol	146-155	transforming growth factor beta 1	Homo sapiens	98-107
8964409-7	1996	Gastrin cells respond to both gastrin-releasing peptide and carbachol but not to cholecystokinin-receptor agonists.	Carbachol	60-69	gastrin	Rattus norvegicus	0-7
8806932-7	1996	Similarly, for carbachol, the responses were significantly lower in the alpha-1-antitrypsin deficiency group (P = 0.001; n = 10) and in specimens resected for carcinoma (P = 0.001; n = 6) than in the nondiseased group (n = 9).	Carbachol	15-24	serpin family A member 1	Homo sapiens	72-91
8717044-3	1996	In NIH-3T3 cells expressing subtype 1 human muscarinic receptors (hm1), the agonist carbachol selectively increased the specific activity and phosphorylation state of epitope-tagged Ras-GRF.	Carbachol	84-93	cholinergic receptor muscarinic 1	Homo sapiens	66-69
8717044-6	1996	In COS-7 cells, cotransfection of hm1 or hm2 receptors with Ras-GRF conferred carbachol-dependent increases in exchange-factor activity, whereas cotransfection with G-protein beta gamma subunits caused a constitutive activation that was sensitive to PP1.	Carbachol	78-87	cholinergic receptor muscarinic 1	Homo sapiens	34-37
8679222-3	1996	Pretreatment of human TSMC with TNF alpha potentiated cytosolic calcium [(Ca2+)i] transients evoked by carbachol.	Carbachol	103-112	tumor necrosis factor	Homo sapiens	32-41
8679222-4	1996	In a similar manner, selective TNF alpha-p55 receptor agonists such as htr-9, an activating monoclonal antibody, or a recombinant TNF-p55 (rTNF-p55), which specifically activates the TNF alpha-p55 receptor but not the TNF alpha-p75 receptor, also augmented [Ca2+]i transients evoked by carbachol.	Carbachol	286-295	tumor necrosis factor	Homo sapiens	31-40
8679222-4	1996	In a similar manner, selective TNF alpha-p55 receptor agonists such as htr-9, an activating monoclonal antibody, or a recombinant TNF-p55 (rTNF-p55), which specifically activates the TNF alpha-p55 receptor but not the TNF alpha-p75 receptor, also augmented [Ca2+]i transients evoked by carbachol.	Carbachol	286-295	tumor necrosis factor	Rattus norvegicus	31-34
8679222-4	1996	In a similar manner, selective TNF alpha-p55 receptor agonists such as htr-9, an activating monoclonal antibody, or a recombinant TNF-p55 (rTNF-p55), which specifically activates the TNF alpha-p55 receptor but not the TNF alpha-p75 receptor, also augmented [Ca2+]i transients evoked by carbachol.	Carbachol	286-295	tumor necrosis factor	Rattus norvegicus	139-143
8679222-4	1996	In a similar manner, selective TNF alpha-p55 receptor agonists such as htr-9, an activating monoclonal antibody, or a recombinant TNF-p55 (rTNF-p55), which specifically activates the TNF alpha-p55 receptor but not the TNF alpha-p75 receptor, also augmented [Ca2+]i transients evoked by carbachol.	Carbachol	286-295	tumor necrosis factor	Homo sapiens	183-192
8679222-4	1996	In a similar manner, selective TNF alpha-p55 receptor agonists such as htr-9, an activating monoclonal antibody, or a recombinant TNF-p55 (rTNF-p55), which specifically activates the TNF alpha-p55 receptor but not the TNF alpha-p75 receptor, also augmented [Ca2+]i transients evoked by carbachol.	Carbachol	286-295	tumor necrosis factor	Homo sapiens	183-192
9807062-2	1996	We found that corticosterone, administered to adrenalectomized rats in vivo, dose-dependently modulates carbachol responsiveness of CA1 hippocampal neurons, recorded subsequently in vitro.	Carbachol	104-113	carbonic anhydrase 1	Rattus norvegicus	132-135
9807062-3	1996	Thus, the carbachol (3 microM) induced membrane depolarization in CA1 neurons was relatively large in hippocampal slices where either (almost) no corticosteroid receptors were activated (0-1 microg corticosterone/100g body weight) or where both MRs and GRs were occupied by high corticosterone doses (100-1000 microg/100g).	Carbachol	10-19	carbonic anhydrase 1	Rattus norvegicus	66-69
8761858-6	1996	In contrast, the increase in MAP evoked by 5.5 and 13.2 nmol CCh could be attenuated by prazosin, yohimbine, or D[(CH2)5Tyr(Me)]AVP (AVPX, a V 1-vasopressin receptor blocker), and completely blocked by the combination of prazosin and AVPX.	Carbachol	61-64	arginine vasopressin	Rattus norvegicus	145-156
8632160-2	1996	The PKC inhibitor Ro 31-7549 inhibited carbachol-evoked NA release (IC(50) 0.6 microM) but not 100 mM (K+)-evoked release.	Carbachol	39-48	protein kinase C alpha	Homo sapiens	4-7
8632160-7	1996	The PKC inhibitor Go-6976 (2 microM), which has been shown to inhibit selectively PKC-alpha and beta in vitro, also inhibited the TPA enhancement of carbachol- and (K+)-evoked NA release by &gt; 50%.	Carbachol	149-158	protein kinase C alpha	Homo sapiens	4-7
8632160-8	1996	These data suggest that in SH-SY5Y cells, the ability of TPA to enhance carbachol- and (K+)-evoked NA secretion is due to activation of PKC-alpha.	Carbachol	72-81	protein kinase C alpha	Homo sapiens	136-145
8877593-5	1996	Benextramine noncompetitively inhibited the pressor response to intravenous injection of NPY and the increase in MAP evoked by CCh microinjection into adrenergic and V1-vasopressin receptor-blocked rats, whereas benextramine competitively inhibited the pressor response to angiotensin II (AII).	Carbachol	127-130	angiotensinogen	Rattus norvegicus	273-287
8877593-5	1996	Benextramine noncompetitively inhibited the pressor response to intravenous injection of NPY and the increase in MAP evoked by CCh microinjection into adrenergic and V1-vasopressin receptor-blocked rats, whereas benextramine competitively inhibited the pressor response to angiotensin II (AII).	Carbachol	127-130	angiotensinogen	Rattus norvegicus	289-292
8877593-8	1996	The similarity in the antagonism of the increase in MAP evoked by intravenous NPY injection and by CCh microinjection into the PHN of adrenergic- and V1-vasopressin receptor-blocked rats suggests that NPY might be released from sympathetic neurons after activation of the sympathetic nervous system by central administration of CCh into the PHN.	Carbachol	328-331	neuropeptide Y	Rattus norvegicus	201-204
8762162-9	1996	Comparisons of the results of AChE inhibition which would elevate acetylcholine (ACh) levels with those of carbachol administration revealed that AChE inhibition affects both cholinergic and non-cholinergic mechanisms underlying the two behaviors.	Carbachol	107-116	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-150
8776663-9	1996	Differential centrifugation studies revealed that Fyn resides predominantly (&gt; 95%) in the crude plasma membrane fraction and undergoes nicotinic-and carbachol-induced activation.	Carbachol	153-162	FYN proto-oncogene, Src family tyrosine kinase	Bos taurus	50-53
8856685-3	1996	Here we report that microinjection of carbachol into the taste cortex modulates protein tyrosine phosphorylation similarly to the effect of unfamiliar taste, and that a 180 kDa protein whose tyrosine phosphorylation is enhanced in vivo by carbachol is NR2B.	Carbachol	38-47	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	252-256
8856685-3	1996	Here we report that microinjection of carbachol into the taste cortex modulates protein tyrosine phosphorylation similarly to the effect of unfamiliar taste, and that a 180 kDa protein whose tyrosine phosphorylation is enhanced in vivo by carbachol is NR2B.	Carbachol	239-248	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	252-256
8631834-3	1996	Carbachol induces robust luciferase responses in Jurkat and pheochromocytoma PC12 cells expressing an NFAT-luciferase reporter construct and a Gq-coupled m3 muscarinic receptor.	Carbachol	0-9	nuclear factor of activated T-cells 5	Rattus norvegicus	102-106
8631834-5	1996	In PC12 cells expressing a Gi-coupled m2 muscarinic receptor, carbachol induces NFAT-mediated luciferase activity that is strictly dependent upon co-expression of a chimeric G alpha q/alpha i subunit, which confers Gq-effector coupling on Gi-linked receptors.	Carbachol	62-71	nuclear factor of activated T-cells 5	Rattus norvegicus	80-84
8626481-3	1996	In this system, the muscarinic agonist carbachol stimulated steady-state PLC activity up to 90-fold in the presence of GTP.	Carbachol	39-48	heparan sulfate proteoglycan 2	Homo sapiens	73-76
8735615-3	1996	In addition, in the presence of carbachol, nociceptin increased the intracellular concentration of Ca2+ (EC50 60 nM).	Carbachol	32-41	prepronociceptin	Homo sapiens	43-53
8735615-3	1996	In addition, in the presence of carbachol, nociceptin increased the intracellular concentration of Ca2+ (EC50 60 nM).	Carbachol	32-41	carbonic anhydrase 2	Homo sapiens	99-102
8638850-10	1996	Microinjection of carbachol into the mPRF before halothane administration caused a significant reduction in number of halothane-induced EEG spindles.	Carbachol	18-27	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	37-41
8732292-5	1996	The Ca2+ response evoked by carbachol (10 microM) was completely blocked by the nAChR antagonist, pancuronium (3 microM), but was not affected by the muscarinic antagonist, atropine (3 microM), or under conditions when Ca2+ entry was blocked by La3+ (50 microM) or diltiazem (10 microM).	Carbachol	28-37	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	80-85
8736117-1	1996	We determined the effect of intracerebroventricular (icv) administration of losartan, an angiotensin II (ANG II) subtype 1 receptor (AT1) antagonist, on icv carbachol-induced natriuresis, kaliuresis and antidiuresis in water-loaded male Holtzman rats (250-300 g) with a cannula implanted into the lateral ventricle (LV).	Carbachol	157-166	angiotensin II receptor, type 1a	Rattus norvegicus	89-136
8609894-2	1996	After transfection with IRK1 and m1 muscarinic receptor genes, tsA cells expressed a cesium-sensitive inwardly rectifying potassium conductance that was reduced on application of the muscarinic receptor agonist carbachol.	Carbachol	211-220	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	24-28
8609894-6	1996	Preincubation with staurosporine or the specific PKC inhibitor calphostin C, before application of carbachol, fully prevented the inhibition of IRK1 by m1 muscarinic receptor stimulation.	Carbachol	99-108	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	144-148
8626438-9	1996	In Xenopus laetis oocytes co-expression of GIRK1 with either the chick M2 or M4 mAChR gave carbamylcholine (10 microm)-stimulated K+ currents of 308 +/-26 nA and 298 +/-29 nA, respectively, which were both Ba2+- and pertussis toxin-sensitive.	Carbachol	91-106	potassium inwardly rectifying channel subfamily J member 3 S homeolog	Xenopus laevis	43-48
8630331-3	1996	The increase of cytosolic free Ca2+ promoted by gastrin, or carbachol, was abolished by the intracellular Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid (BAPTA, 10 microM).	Carbachol	60-69	gastrin	Rattus norvegicus	48-55
8882619-9	1996	Endothelin-1 was a potent spasmogen in isolated tracheal airway smooth muscle preparations from control mice (ED70 = concentration producing 70% of contraction induced by 10 microM carbachol = 6.3 nM (95% confidence limits, 4.0-10; n = 6 mice)).	Carbachol	181-190	endothelin 1	Mus musculus	0-12
8851175-3	1996	Interestingly, when EoL-1 cells were treated with interferon-gamma, mRNAs for muscarinic M3 and M5 receptors could be detected in these cells, along with an increase in [Ca2+]i and chemotaxis induced by carbachol that could be blocked with 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) and pirenzepine.	Carbachol	203-212	interferon gamma	Homo sapiens	50-66
8778283-7	1996	Coexpression of the m1 muscarinic receptor with the dopamine-D2 receptor permitted dopamine to stimulate AC-II in the presence of carbachol.	Carbachol	130-139	dopamine receptor D2	Homo sapiens	52-72
8621433-5	1996	Carbachol and bombesin also stimulated JNK activity, while vasoactive intestinal peptide did not.	Carbachol	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	39-42
8769893-2	1996	Carbachol treatment increased the levels of intracellular Ca2+ and inositol 1,4,5-trisphosphate (IP3) and enhanced transcription of the TH gene.	Carbachol	0-9	tyrosine hydroxylase	Rattus norvegicus	136-138
8769893-3	1996	The muscarinic receptor antagonist atropine completely abolished the carbachol effect on TH gene expression.	Carbachol	69-78	tyrosine hydroxylase	Rattus norvegicus	89-91
8769893-5	1996	Transient transfection analysis of the 5" upstream region of TH gene revealed that the AP1 cis-acting element at -205 to -199 bp was responsible for carbachol stimulation.	Carbachol	149-158	tyrosine hydroxylase	Rattus norvegicus	61-63
8769893-5	1996	Transient transfection analysis of the 5" upstream region of TH gene revealed that the AP1 cis-acting element at -205 to -199 bp was responsible for carbachol stimulation.	Carbachol	149-158	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	87-90
8769893-7	1996	Thus, Ca(2+)-independent PKC may play a role in carbachol-induced TH gene expression.	Carbachol	48-57	tyrosine hydroxylase	Rattus norvegicus	66-68
8596722-4	1996	In contrast, two specific peptide inhibitors of Ca2+/calmodulin-dependent protein kinase II (CaM-K II), each partially blocked the effect of carbachol, but not the effect of t-ACPD on IAHP.	Carbachol	141-150	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	48-91
8596722-4	1996	In contrast, two specific peptide inhibitors of Ca2+/calmodulin-dependent protein kinase II (CaM-K II), each partially blocked the effect of carbachol, but not the effect of t-ACPD on IAHP.	Carbachol	141-150	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	93-102
8779914-9	1996	Serum-, carbachol-, and thapsigargin-stimulated [Ca2+]i elevations were reduced by 90, 60, and &gt; 65%, respectively, in cells treated with IFN-gamma +/- TNF-alpha and 30, 45, and 45%, respectively, in cells treated with TNF-alpha.	Carbachol	8-17	interferon gamma	Homo sapiens	141-150
8812728-0	1996	Effects of carbamylcholine and pyridostigmine on mitochondrial-bound hexokinase in skeletal muscle and heart.	Carbachol	11-26	hexokinase 1	Homo sapiens	69-79
8812728-1	1996	We show here that carbamylcholine (acetylcholine agonist) or pyridostigmine (acetylcholinesterase inhibitor), drugs which are widely used in medical treatments, exerted a rapid reduction in mitochondrial-bound hexokinase.	Carbachol	18-33	hexokinase 1	Homo sapiens	210-220
8779914-9	1996	Serum-, carbachol-, and thapsigargin-stimulated [Ca2+]i elevations were reduced by 90, 60, and &gt; 65%, respectively, in cells treated with IFN-gamma +/- TNF-alpha and 30, 45, and 45%, respectively, in cells treated with TNF-alpha.	Carbachol	8-17	tumor necrosis factor	Homo sapiens	155-164
8779914-9	1996	Serum-, carbachol-, and thapsigargin-stimulated [Ca2+]i elevations were reduced by 90, 60, and &gt; 65%, respectively, in cells treated with IFN-gamma +/- TNF-alpha and 30, 45, and 45%, respectively, in cells treated with TNF-alpha.	Carbachol	8-17	tumor necrosis factor	Homo sapiens	222-231
8660281-14	1996	Although down regulation of total PKC by up to 90% did not significantly affect the secretory response to carbachol, RO 31-8220, a relatively specific inhibitor of PKC, abolished carbachol-induced secretion in normal as well as in PMA-down-regulated cells.	Carbachol	179-188	Prkca	Cavia porcellus	164-167
8660281-15	1996	This indicates that a PKC isoform resistant to down regulation by PMA is involved in carbachol- but not in cAMP-mediated secretion.	Carbachol	85-94	Prkca	Cavia porcellus	22-25