PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21702743-8	2011	Binding of the oligomers may be, in part, mediated by the GM1 ganglioside receptors as there is a 1.8-fold increase in oligomeric Abeta binding and a 2-fold increase in permeation compared with when GM1 is not present.	G(M1) Ganglioside	58-61	amyloid beta precursor protein	Homo sapiens	130-135
21708455-2	2011	It is highly likely that the interaction of lipid raft components like cholesterol, sphingomylein or GM1 leads to nucleation of Abeta and results in aggregation or accumulation of amyloid plaques.	G(M1) Ganglioside	101-104	amyloid beta precursor protein	Homo sapiens	128-133
21165949-4	2011	GD1a is synthesized from GM1 by alpha2,3 sialyltransferase (ST3Gal) I and mainly by ST3Gal II.	G(M1) Ganglioside	25-28	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	32-69
21682276-4	2011	In this paper, the mechanism by which Abeta-(1-40) fibrillizes in raftlike lipid bilayers composed of monosialoganglioside GM1, cholesterol, and sphingomyelin was investigated in detail on the basis of singular-value decomposition of circular dichroism data and analysis of fibrillization kinetics.	G(M1) Ganglioside	123-126	amyloid beta precursor protein	Homo sapiens	38-43
21723896-4	2011	With the purpose of further investigating a possible mechanism of action, we analyzed the effect of GM1 treatment (1, 6, 12 and 24h) upon the Abeta-induced alterations on GSK3beta dephosphorylation/activation state.	G(M1) Ganglioside	100-103	glycogen synthase kinase 3 beta	Homo sapiens	171-179
21723896-5	2011	Results demonstrated an important effect after 24-h incubation, with GM1 preventing the Abeta-induced dephosphorylation (activation) of GSK3beta, a signaling pathway involved in apoptosis triggering and neuronal death in models of Alzheimer"s disease.	G(M1) Ganglioside	69-72	glycogen synthase kinase 3 beta	Homo sapiens	136-144
22040436-7	2011	The purified rCTB could bind with GM1 efficiently.	G(M1) Ganglioside	34-37	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	13-17
21665948-5	2011	Among a panel of B cell lines, expression of GM1 was negatively correlated with and suppressed by gene expression of CD77 synthase (CD77Syn), whereas no significant positive correlation was found for enzymes actually biosynthesizing GM1.	G(M1) Ganglioside	45-48	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	117-130
21665948-5	2011	Among a panel of B cell lines, expression of GM1 was negatively correlated with and suppressed by gene expression of CD77 synthase (CD77Syn), whereas no significant positive correlation was found for enzymes actually biosynthesizing GM1.	G(M1) Ganglioside	45-48	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	132-139
21665948-6	2011	Unexpectedly, a GM1-suppressive phenotype was also observed in the expression of catalytically inactive CD77Syn, ruling out catalytic consumption of lactosylceramide (LacCer) as the main cause for such negative regulation.	G(M1) Ganglioside	16-19	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	104-111
21447051-9	2011	Proper folding and display of conformational epitopes for both LTB and L1 in the fusion protein was confirmed by GM1-ganglioside binding assay and antigen capture ELISA, respectively.	G(M1) Ganglioside	113-128	lymphotoxin beta	Homo sapiens	63-66
21447051-9	2011	Proper folding and display of conformational epitopes for both LTB and L1 in the fusion protein was confirmed by GM1-ganglioside binding assay and antigen capture ELISA, respectively.	G(M1) Ganglioside	113-128	immunoglobulin kappa variable 1-16	Homo sapiens	71-73
21692120-2	2011	Ganglioside GM1 has been shown to enhance the aggregation of Abeta, but the underlying mechanism is unknown.	G(M1) Ganglioside	0-15	amyloid beta precursor protein	Homo sapiens	61-66
21708114-6	2011	Unexpectedly, GM1 accumulation in double mutants increased compared to single mutants consistent with a direct role for NPC1 in ganglioside salvage.	G(M1) Ganglioside	14-17	NPC intracellular cholesterol transporter 1	Mus musculus	120-124
21682276-8	2011	At Abeta:GM1 ratios above ~0.044, the beta-structure is converted to a second, seed-prone beta-structure.	G(M1) Ganglioside	9-12	amyloid beta precursor protein	Homo sapiens	3-8
20937248-0	2011	NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles.	G(M1) Ganglioside	16-19	tachykinin precursor 1	Homo sapiens	53-64
21396938-5	2011	Surface pressure measurements of GSL monolayers at the air-water interface allowed us to determine the following order for alpha-synuclein-GSL interactions: GM3>Gb3>GalCer-NFA>GM1>sulfatide>GalCer-HFA>LacCer>GM4>GM2>asialo-GM1>GD3, indicating a marked preference for GSLs with one, three, or five sugar units.	G(M1) Ganglioside	185-188	synuclein alpha	Homo sapiens	123-138
21295117-5	2011	Immunohistochemical studies indicated that AQP5, under unstimulated conditions, colocalised with flotillin-2 and GM1 with a diffuse pattern in the apical cytoplasm of acinar and duct cells in both control and diabetic rats.	G(M1) Ganglioside	113-116	aquaporin 5	Rattus norvegicus	43-47
21226491-4	2011	The cellular CTB-receptor, ganglioside GM1, contains a pentasaccharide moiety consisting in part of galactose and glucose units.	G(M1) Ganglioside	39-42	phosphate cytidylyltransferase 1B, choline	Homo sapiens	13-16
21497194-2	2011	Here we report the beta-galactosidase gene (GLB1) mutation analysis of 21 unrelated GM1 gangliosidosis patients, and of 4 Morquio B patients, of whom two are brothers.	G(M1) Ganglioside	84-87	galactosidase beta 1	Homo sapiens	44-48
21508255-9	2011	Our data suggest that the GM1 storage seen in the beta-gal(-/-) mouse contributes to the filipin ultraviolet fluorescence observed in GM1 gangliosidosis brain.	G(M1) Ganglioside	26-29	galactosidase, beta 1	Mus musculus	50-58
21508255-9	2011	Our data suggest that the GM1 storage seen in the beta-gal(-/-) mouse contributes to the filipin ultraviolet fluorescence observed in GM1 gangliosidosis brain.	G(M1) Ganglioside	134-137	galactosidase, beta 1	Mus musculus	50-58
21376833-3	2011	Using detergent-resistant membrane (DRM) assays, as well as transmembrane (TM) interactions and ganglioside GM1 binding, we present evidence supporting the localization of podoplanin in raft platforms important for cell signalling.	G(M1) Ganglioside	108-111	podoplanin	Canis lupus familiaris	172-182
20971126-10	2011	In hippocampal neurons, both GM1 ganglioside and KCl evoked within minutes the release of mature BDNF.	G(M1) Ganglioside	29-44	brain derived neurotrophic factor	Homo sapiens	97-101
20971126-11	2011	In human cells, GM1 and other gangliosides released both mature BDNF and pro-BDNF.	G(M1) Ganglioside	16-19	brain derived neurotrophic factor	Homo sapiens	64-68
20971126-11	2011	In human cells, GM1 and other gangliosides released both mature BDNF and pro-BDNF.	G(M1) Ganglioside	16-19	brain derived neurotrophic factor	Homo sapiens	77-81
20971126-13	2011	In fact, GT1b preferentially released mature BDNF whereas GM1 released both mature and pro-BDNF.	G(M1) Ganglioside	58-61	brain derived neurotrophic factor	Homo sapiens	91-95
21396938-5	2011	Surface pressure measurements of GSL monolayers at the air-water interface allowed us to determine the following order for alpha-synuclein-GSL interactions: GM3>Gb3>GalCer-NFA>GM1>sulfatide>GalCer-HFA>LacCer>GM4>GM2>asialo-GM1>GD3, indicating a marked preference for GSLs with one, three, or five sugar units.	G(M1) Ganglioside	250-253	synuclein alpha	Homo sapiens	123-138
21396938-10	2011	The interaction of Abeta 5-16 with GM1 involved R5, H13, H14, and K16, but not Y10.	G(M1) Ganglioside	35-38	amyloid beta precursor protein	Homo sapiens	19-24
21245496-8	2011	The deactivation of NK cells with anti-asialo GM1 treatment attenuated liver injury and the increase in plasma IFN-gamma compared with immunoglobulin G-treated control mice.	G(M1) Ganglioside	46-49	interferon gamma	Mus musculus	111-120
21226491-5	2011	We therefore predicted that CTB would recognize carbohydrate-conjugated iron oxide nanoparticles as GM1 mimics, thus producing a detectable change in the T2 relaxation times.	G(M1) Ganglioside	100-103	phosphate cytidylyltransferase 1B, choline	Homo sapiens	28-31
21226491-10	2011	Additional experiments demonstrated that the dextran-coated nanoparticle can also be used as CTB sensors and that dextran can prevent the internalization of CTB into GM1-expressing cells.	G(M1) Ganglioside	166-169	phosphate cytidylyltransferase 1B, choline	Homo sapiens	157-160
20721666-5	2011	The CTB-LipL32 protein demonstrated strong affinity for monosialotetrahexosylgaglioside (GM1-ganglioside) in an enzyme-linked immunosorbent assay (ELISA), suggesting that the antigenic sites for binding and proper folding of the pentameric CTB structure were conserved.	G(M1) Ganglioside	89-104	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	4-7
20721666-5	2011	The CTB-LipL32 protein demonstrated strong affinity for monosialotetrahexosylgaglioside (GM1-ganglioside) in an enzyme-linked immunosorbent assay (ELISA), suggesting that the antigenic sites for binding and proper folding of the pentameric CTB structure were conserved.	G(M1) Ganglioside	89-104	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	240-243
20937248-5	2011	In the present work, we describe the conformations of Substance P in the presence of ternary membrane systems containing GM1 at the physiological concentration.	G(M1) Ganglioside	121-124	tachykinin precursor 1	Homo sapiens	54-65
20937248-6	2011	SP is mostly unstructured in water, but appears as extended 3(10) helical or turn III in isotropic bicelles, more pronounced in the presence of GM1.	G(M1) Ganglioside	144-147	tachykinin precursor 1	Homo sapiens	0-2
20937248-8	2011	The NMR-derived conformation of SP in GM1 bicelles is docked on homology modeled NK(1)R and resulting interactions satisfy reported mutagenesis, fluorescence, photo-affinity labeling and modeling data.	G(M1) Ganglioside	38-41	tachykinin precursor 1	Homo sapiens	32-34
20937248-8	2011	The NMR-derived conformation of SP in GM1 bicelles is docked on homology modeled NK(1)R and resulting interactions satisfy reported mutagenesis, fluorescence, photo-affinity labeling and modeling data.	G(M1) Ganglioside	38-41	tachykinin receptor 1	Homo sapiens	81-87
20937248-9	2011	The results highlight efficacy of GM1 in membrane in providing structure in an otherwise flexible neurotransmitter Substance P; thus providing indication that it may be useful also for other neurotransmitter peptides/proteins associated with membrane.	G(M1) Ganglioside	34-37	tachykinin precursor 1	Homo sapiens	115-126
21949831-7	2011	The structures of Gal-3 carbohydrate recognition domain (CRD) complexed with TF antigen and derivatives, TFN and GM1, were then determined.	G(M1) Ganglioside	113-116	galectin 3	Homo sapiens	18-23
21481337-3	2011	Visualization of the cross-linked ganglioside(M1) (GM(1)) using fluorescent labeled CTB, indicated accumulation of the fluorescence to one cap and a few smaller patches in both type of cells.	G(M1) Ganglioside	51-56	phosphate cytidylyltransferase 1B, choline	Homo sapiens	84-87
21468353-6	2011	The binding of CTB to GM1-lipid complexes in membrane exvaginations or tips of membrane nanotubes may reduce the positive spontaneous (intrinsic) curvature of GM1-lipid complexes, which may lead to lipid mediated attractive interactions between CTB-GM1-lipid complexes, their aggregation and consequent formation of enlarged spherical tips of nanotubes.	G(M1) Ganglioside	22-25	phosphate cytidylyltransferase 1B, choline	Homo sapiens	15-18
21468353-6	2011	The binding of CTB to GM1-lipid complexes in membrane exvaginations or tips of membrane nanotubes may reduce the positive spontaneous (intrinsic) curvature of GM1-lipid complexes, which may lead to lipid mediated attractive interactions between CTB-GM1-lipid complexes, their aggregation and consequent formation of enlarged spherical tips of nanotubes.	G(M1) Ganglioside	22-25	phosphate cytidylyltransferase 1B, choline	Homo sapiens	245-248
21468353-6	2011	The binding of CTB to GM1-lipid complexes in membrane exvaginations or tips of membrane nanotubes may reduce the positive spontaneous (intrinsic) curvature of GM1-lipid complexes, which may lead to lipid mediated attractive interactions between CTB-GM1-lipid complexes, their aggregation and consequent formation of enlarged spherical tips of nanotubes.	G(M1) Ganglioside	159-162	phosphate cytidylyltransferase 1B, choline	Homo sapiens	15-18
21468353-6	2011	The binding of CTB to GM1-lipid complexes in membrane exvaginations or tips of membrane nanotubes may reduce the positive spontaneous (intrinsic) curvature of GM1-lipid complexes, which may lead to lipid mediated attractive interactions between CTB-GM1-lipid complexes, their aggregation and consequent formation of enlarged spherical tips of nanotubes.	G(M1) Ganglioside	159-162	phosphate cytidylyltransferase 1B, choline	Homo sapiens	15-18
21468353-7	2011	The binding of CTB to GM1 molecules in the outer membrane leaflet of membrane exvaginations and tips of membrane nanotubes may also increase the area difference between the two leaflets and in this way facilitate the growth of membrane nanotubes.	G(M1) Ganglioside	22-25	phosphate cytidylyltransferase 1B, choline	Homo sapiens	15-18
20667861-7	2011	RESULTS: C1q, C4b, C3b and C5b-9 were deposited on GM1-coated wells.	G(M1) Ganglioside	51-54	complement C1q A chain	Homo sapiens	9-12
20667861-7	2011	RESULTS: C1q, C4b, C3b and C5b-9 were deposited on GM1-coated wells.	G(M1) Ganglioside	51-54	endogenous retrovirus group K member 3	Homo sapiens	19-22
21489413-0	2011	CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.	G(M1) Ganglioside	58-61	CD4 molecule	Homo sapiens	0-3
21489413-0	2011	CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.	G(M1) Ganglioside	58-61	caspase recruitment domain family member 11	Homo sapiens	26-32
21489413-0	2011	CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.	G(M1) Ganglioside	58-61	BCL10 immune signaling adaptor	Homo sapiens	33-38
21489413-0	2011	CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.	G(M1) Ganglioside	58-61	MALT1 paracaspase	Homo sapiens	39-44
21489413-0	2011	CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.	G(M1) Ganglioside	58-61	CD28 molecule	Homo sapiens	93-97
21489413-3	2011	We report that treatment of CD3/CD28-activated Jurkat T cells with 13B8.2, but not rituximab, excluded Carma1-Bcl10-MALT1 proteins from GM1(+) membrane rafts and concomitantly decreased NF-kappaB activation.	G(M1) Ganglioside	136-139	CD28 molecule	Homo sapiens	32-36
21489413-3	2011	We report that treatment of CD3/CD28-activated Jurkat T cells with 13B8.2, but not rituximab, excluded Carma1-Bcl10-MALT1 proteins from GM1(+) membrane rafts and concomitantly decreased NF-kappaB activation.	G(M1) Ganglioside	136-139	caspase recruitment domain family member 11	Homo sapiens	103-109
21489413-4	2011	Fluorescence confocal imaging confirmed that Carma1-Bcl10 and Carma1-MALT1 co-patching, observed in GM1(+) membrane rafts following CD3/CD28 activation, were abrogated after a 24h-treatment with 13B8.2.	G(M1) Ganglioside	100-103	caspase recruitment domain family member 11	Homo sapiens	45-51
21489413-4	2011	Fluorescence confocal imaging confirmed that Carma1-Bcl10 and Carma1-MALT1 co-patching, observed in GM1(+) membrane rafts following CD3/CD28 activation, were abrogated after a 24h-treatment with 13B8.2.	G(M1) Ganglioside	100-103	BCL10 immune signaling adaptor	Homo sapiens	52-57
21489413-4	2011	Fluorescence confocal imaging confirmed that Carma1-Bcl10 and Carma1-MALT1 co-patching, observed in GM1(+) membrane rafts following CD3/CD28 activation, were abrogated after a 24h-treatment with 13B8.2.	G(M1) Ganglioside	100-103	caspase recruitment domain family member 11	Homo sapiens	62-68
21489413-4	2011	Fluorescence confocal imaging confirmed that Carma1-Bcl10 and Carma1-MALT1 co-patching, observed in GM1(+) membrane rafts following CD3/CD28 activation, were abrogated after a 24h-treatment with 13B8.2.	G(M1) Ganglioside	100-103	MALT1 paracaspase	Homo sapiens	69-74
21489413-4	2011	Fluorescence confocal imaging confirmed that Carma1-Bcl10 and Carma1-MALT1 co-patching, observed in GM1(+) membrane rafts following CD3/CD28 activation, were abrogated after a 24h-treatment with 13B8.2.	G(M1) Ganglioside	100-103	CD28 molecule	Homo sapiens	136-140
20659560-5	2010	The data show that anti-GM1 antibodies found in patients" sera but not control sera inhibit NGF-induced Trk autophosphorylation.	G(M1) Ganglioside	24-27	neurotrophic receptor tyrosine kinase 1	Homo sapiens	104-107
21044592-4	2010	Using the ganglioside GM1 as a model GSL, and two mass-sensitive and label-free characterization techniques-quartz crystal microbalance with dissipation monitoring and ellipsometry-we demonstrate that GLTP is an efficient and robust biochemical tool to dynamically modulate the GSL content of SLBs up to 10 mol % GM1, and to quantitatively control the GSL content in the bulk-facing SLB leaflet.	G(M1) Ganglioside	22-25	glycolipid transfer protein	Homo sapiens	201-205
21044592-4	2010	Using the ganglioside GM1 as a model GSL, and two mass-sensitive and label-free characterization techniques-quartz crystal microbalance with dissipation monitoring and ellipsometry-we demonstrate that GLTP is an efficient and robust biochemical tool to dynamically modulate the GSL content of SLBs up to 10 mol % GM1, and to quantitatively control the GSL content in the bulk-facing SLB leaflet.	G(M1) Ganglioside	313-316	glycolipid transfer protein	Homo sapiens	201-205
21044592-7	2010	Furthermore, we quantify the liganding affinity of GLTP for GM1 in an SLB context to be 1.5 muM.	G(M1) Ganglioside	60-63	glycolipid transfer protein	Homo sapiens	51-55
20858460-0	2010	Echinophilic proteins stomatin, sorcin, and synexin locate outside gangliosideM1 (GM1) patches in the erythrocyte membrane.	G(M1) Ganglioside	82-85	sorcin	Homo sapiens	32-38
20858460-0	2010	Echinophilic proteins stomatin, sorcin, and synexin locate outside gangliosideM1 (GM1) patches in the erythrocyte membrane.	G(M1) Ganglioside	82-85	annexin A7	Homo sapiens	44-51
20858460-6	2010	The study indicates that stomatin, sorcin, and synexin are echinophilic membrane components that mainly locate outside GM1 rafts in the human erythrocyte membrane.	G(M1) Ganglioside	119-122	sorcin	Homo sapiens	35-41
20858460-6	2010	The study indicates that stomatin, sorcin, and synexin are echinophilic membrane components that mainly locate outside GM1 rafts in the human erythrocyte membrane.	G(M1) Ganglioside	119-122	annexin A7	Homo sapiens	47-54
20117237-4	2010	On the basis of these characteristics, it was hypothesized that Abeta adopts an altered conformation following interaction with GM1, leading to the generation of GAbeta, and then GAbeta acts as an endogenous seed for Alzheimer amyloid in the brain.	G(M1) Ganglioside	128-131	alpha glucosidase	Homo sapiens	162-168
20175788-1	2010	GM1 gangliosidosis manifests with progressive psychomotor deterioration and dysostosis of infantile, juvenile, or adult onset, caused by alterations in the structural gene coding for lysosomal acid beta-galactosidase (GLB1).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	193-216
20175788-1	2010	GM1 gangliosidosis manifests with progressive psychomotor deterioration and dysostosis of infantile, juvenile, or adult onset, caused by alterations in the structural gene coding for lysosomal acid beta-galactosidase (GLB1).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	218-222
20175788-3	2010	More than 100 sequence alterations in the GLB1 gene have been identified so far, but only few could be proven to be predictive for one of the GM1 gangliosidosis subtypes or MBD.	G(M1) Ganglioside	142-145	galactosidase beta 1	Homo sapiens	42-46
20920281-0	2010	Three novel beta-galactosidase gene mutations in Han Chinese patients with GM1 gangliosidosis are correlated with disease severity.	G(M1) Ganglioside	75-78	galactosidase beta 1	Homo sapiens	12-30
20920281-1	2010	BACKGROUND: GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease caused by deficiency of acid beta-galactosidase (GLB1; EC3.2.1.23).	G(M1) Ganglioside	12-15	galactosidase beta 1	Homo sapiens	138-142
20920281-1	2010	BACKGROUND: GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease caused by deficiency of acid beta-galactosidase (GLB1; EC3.2.1.23).	G(M1) Ganglioside	32-35	galactosidase beta 1	Homo sapiens	138-142
20920281-2	2010	Here, we identify three novel mutations in the GLB1 gene from two Han Chinese patients with GM1 that appear correlated with clinical phenotype.	G(M1) Ganglioside	92-95	galactosidase beta 1	Homo sapiens	47-51
20599476-2	2010	Previous studies suggest that ganglioside-bound amyloid beta-protein (Abeta), GAbeta, is an endogenous seed for amyloid in Alzheimer"s disease (AD) brain and that GAbeta is generated in the membrane microdomains, comprising cholesterol, sphingomyelin (SM) and GM1 ganglioside.	G(M1) Ganglioside	260-263	amyloid beta precursor protein	Rattus norvegicus	70-75
20599476-2	2010	Previous studies suggest that ganglioside-bound amyloid beta-protein (Abeta), GAbeta, is an endogenous seed for amyloid in Alzheimer"s disease (AD) brain and that GAbeta is generated in the membrane microdomains, comprising cholesterol, sphingomyelin (SM) and GM1 ganglioside.	G(M1) Ganglioside	260-263	alpha glucosidase	Rattus norvegicus	78-84
20599476-2	2010	Previous studies suggest that ganglioside-bound amyloid beta-protein (Abeta), GAbeta, is an endogenous seed for amyloid in Alzheimer"s disease (AD) brain and that GAbeta is generated in the membrane microdomains, comprising cholesterol, sphingomyelin (SM) and GM1 ganglioside.	G(M1) Ganglioside	260-263	alpha glucosidase	Rattus norvegicus	163-169
20093028-0	2010	T cells from patients with Guillain-Barre syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1.	G(M1) Ganglioside	124-127	interferon gamma	Homo sapiens	59-75
20653774-5	2010	NK cell depletion was accompanied by a significant increase in the number of perifollicular CD49b+T cells in the alopecic skin of anti-asialo GM1-treated mice.	G(M1) Ganglioside	142-145	integrin alpha 2	Mus musculus	92-97
20374557-1	2010	In neuroendocrine cells, annexin-A2 is implicated as a promoter of monosialotetrahexosylganglioside (GM1)-containing lipid microdomains that are required for calcium-regulated exocytosis.	G(M1) Ganglioside	67-99	annexin A2	Homo sapiens	25-35
20374557-1	2010	In neuroendocrine cells, annexin-A2 is implicated as a promoter of monosialotetrahexosylganglioside (GM1)-containing lipid microdomains that are required for calcium-regulated exocytosis.	G(M1) Ganglioside	101-104	annexin A2	Homo sapiens	25-35
20226163-1	2010	Ganglioside GM1 mediates the amyloid beta (Abeta) aggregation that is the hallmark of Alzheimer"s disease (AD).	G(M1) Ganglioside	12-15	amyloid beta precursor protein	Homo sapiens	29-41
20226163-1	2010	Ganglioside GM1 mediates the amyloid beta (Abeta) aggregation that is the hallmark of Alzheimer"s disease (AD).	G(M1) Ganglioside	12-15	amyloid beta precursor protein	Homo sapiens	43-48
20226163-4	2010	Surprisingly high-speed Abeta aggregation of fibril formations occurred at all GM1 concentrations examined on the mica surface, but on the SiO(2) surface, only globular agglomerates formed and they formed slowly.	G(M1) Ganglioside	79-82	amyloid beta precursor protein	Homo sapiens	24-29
20132476-4	2010	Insulin treatment induced a decrease in GM1 ganglioside (GM1) levels in detergent-resistant membrane microdomains of NGF-treated PC12 cells.	G(M1) Ganglioside	40-55	nerve growth factor	Rattus norvegicus	117-120
20132476-4	2010	Insulin treatment induced a decrease in GM1 ganglioside (GM1) levels in detergent-resistant membrane microdomains of NGF-treated PC12 cells.	G(M1) Ganglioside	40-43	nerve growth factor	Rattus norvegicus	117-120
20177724-3	2010	Peripheral administration of nonimmunization substances, such as GM1 ganglioside, also reduced brain Abeta.	G(M1) Ganglioside	65-80	amyloid beta precursor protein	Homo sapiens	101-106
20117237-2	2010	We previously identified a novel Abeta species, which was characterized by its tight binding to GM1 ganglioside (GM1), in the brain showing early pathological changes of AD.	G(M1) Ganglioside	96-111	amyloid beta precursor protein	Homo sapiens	33-38
20117237-2	2010	We previously identified a novel Abeta species, which was characterized by its tight binding to GM1 ganglioside (GM1), in the brain showing early pathological changes of AD.	G(M1) Ganglioside	96-99	amyloid beta precursor protein	Homo sapiens	33-38
20117237-4	2010	On the basis of these characteristics, it was hypothesized that Abeta adopts an altered conformation following interaction with GM1, leading to the generation of GAbeta, and then GAbeta acts as an endogenous seed for Alzheimer amyloid in the brain.	G(M1) Ganglioside	128-131	amyloid beta precursor protein	Homo sapiens	64-69
20546707-2	2010	The objective of this study is to determine whether GM1 is able to ameliorate hyperglycemia-exacerbated ischemic brain damage in hyperglycemia-recruited areas such as the hippocampal CA3 sub regions and the cingulated cortex.	G(M1) Ganglioside	52-55	carbonic anhydrase 3	Rattus norvegicus	183-186
20546707-4	2010	The results showed that GM1 ameliorated ischemic neuronal injuries in the CA3 area and cingulated cortex of the hyperglycemic animals after ischemia and reperfusion.	G(M1) Ganglioside	24-27	carbonic anhydrase 3	Rattus norvegicus	74-77
20546707-5	2010	Immunohistochemistry of phospho-ERK1/2 revealed that the neuroprotective effects of GM1 were associated with suppression of phospho-ERK1/2.	G(M1) Ganglioside	84-87	mitogen activated protein kinase 3	Rattus norvegicus	32-38
20546707-5	2010	Immunohistochemistry of phospho-ERK1/2 revealed that the neuroprotective effects of GM1 were associated with suppression of phospho-ERK1/2.	G(M1) Ganglioside	84-87	mitogen activated protein kinase 3	Rattus norvegicus	132-138
20546707-6	2010	The results suggest that GM1 attenuates diabetic-augmented ischemic neuronal injuries probably through suppression of ERK1/2 phosphorylation.	G(M1) Ganglioside	25-28	mitogen activated protein kinase 3	Rattus norvegicus	118-124
20153839-6	2010	Strikingly, the lipid raft marker GM1 aggregates upon cholesterol depletion and these aggregated domains concentrate the signalling proteins Lck and LAT, whereas the opposite is true for the non lipid raft marker the transferrin receptor.	G(M1) Ganglioside	34-37	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-144
20153839-6	2010	Strikingly, the lipid raft marker GM1 aggregates upon cholesterol depletion and these aggregated domains concentrate the signalling proteins Lck and LAT, whereas the opposite is true for the non lipid raft marker the transferrin receptor.	G(M1) Ganglioside	34-37	linker for activation of T cells	Homo sapiens	149-152
20535419-1	2010	The subunit B of cholera toxin (CTB), which specifically binds with ganglioside GM1 enriched in membrane lipid rafts, is known to interfere with multiple cell functions.	G(M1) Ganglioside	68-83	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	32-35
20171893-6	2010	It was found that GM1 and NGF can increase the viability of neurons incubated with Glu, which, after GM1 and NGF treatment, were almost morphologically normal.	G(M1) Ganglioside	18-21	nerve growth factor	Rattus norvegicus	109-112
20171893-6	2010	It was found that GM1 and NGF can increase the viability of neurons incubated with Glu, which, after GM1 and NGF treatment, were almost morphologically normal.	G(M1) Ganglioside	101-104	nerve growth factor	Rattus norvegicus	26-29
20171893-8	2010	The mRNA of NF-L was expressed at the highest level in neurons treated with Glu plus GM1 and NGF.	G(M1) Ganglioside	85-88	neurofilament light chain	Rattus norvegicus	12-16
20171893-10	2010	NGF and GM1 may function by maintaining normal mitochondrial membrane potential or by promoting NF-L mRNA expression.	G(M1) Ganglioside	8-11	neurofilament light chain	Rattus norvegicus	96-100
20093028-8	2010	There was significantly increased production of interferon-gamma but not interleukin-5 in response to stimulation with the ganglioside GM1.	G(M1) Ganglioside	135-138	interferon gamma	Homo sapiens	48-64
20237277-5	2010	Administration of GM1 restores ganglioside levels in HD cells and promotes activation of AKT and phosphorylation of mutant Htt, leading to decreased mutant Htt toxicity and increased survival of HD cells.	G(M1) Ganglioside	18-21	AKT serine/threonine kinase 1	Homo sapiens	89-92
20237277-5	2010	Administration of GM1 restores ganglioside levels in HD cells and promotes activation of AKT and phosphorylation of mutant Htt, leading to decreased mutant Htt toxicity and increased survival of HD cells.	G(M1) Ganglioside	18-21	huntingtin	Homo sapiens	123-126
20137986-5	2010	Thus, TCR contact with antigen upregulates GM1 and amplifies responsiveness of naive CD8(+) T cells to IL-2, thereby making the cells highly sensitive to exogenous IL-2 from CD4(+) T helper cells.	G(M1) Ganglioside	43-46	CD4 molecule	Homo sapiens	174-177
20137986-2	2010	Hypersensitivity of CD8(+) T cells to IL-2 was dependent on a low-level TCR signal, associated with high expression of CD5 and GM1, a marker for lipid rafts, and was abolished by disruption of lipid rafts.	G(M1) Ganglioside	127-130	CD8a molecule	Homo sapiens	20-23
19269155-7	2010	The shift from sialylated GSLs to asialo GM1 was achieved by the combinational and tissue-specific transcriptional down-regulation of GM3 synthase and GM1-beta-galactosidase at around 2 weeks of age.	G(M1) Ganglioside	41-44	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	134-146
19269155-7	2010	The shift from sialylated GSLs to asialo GM1 was achieved by the combinational and tissue-specific transcriptional down-regulation of GM3 synthase and GM1-beta-galactosidase at around 2 weeks of age.	G(M1) Ganglioside	41-44	galactosidase, beta 1	Mus musculus	155-173
20137986-2	2010	Hypersensitivity of CD8(+) T cells to IL-2 was dependent on a low-level TCR signal, associated with high expression of CD5 and GM1, a marker for lipid rafts, and was abolished by disruption of lipid rafts.	G(M1) Ganglioside	127-130	interleukin 2	Homo sapiens	38-42
20064199-3	2010	Here we show that in primary CD4+ T cells that are natural targets of HIV-1 in vivo, Gag modulates HIV-1 envelope association with GM1 ganglioside and CD59 rich cellular compartments as well as with detergent resistant membranes.	G(M1) Ganglioside	131-146	Pr55(Gag)	Human immunodeficiency virus 1	85-88
20137986-2	2010	Hypersensitivity of CD8(+) T cells to IL-2 was dependent on a low-level TCR signal, associated with high expression of CD5 and GM1, a marker for lipid rafts, and was abolished by disruption of lipid rafts.	G(M1) Ganglioside	127-130	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	72-75
20137986-3	2010	By contrast, CD4(+) T cells expressed low amounts of GM1 and were unresponsive to IL-2.	G(M1) Ganglioside	53-56	CD4 molecule	Homo sapiens	13-16
20137986-5	2010	Thus, TCR contact with antigen upregulates GM1 and amplifies responsiveness of naive CD8(+) T cells to IL-2, thereby making the cells highly sensitive to exogenous IL-2 from CD4(+) T helper cells.	G(M1) Ganglioside	43-46	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	6-9
20137986-5	2010	Thus, TCR contact with antigen upregulates GM1 and amplifies responsiveness of naive CD8(+) T cells to IL-2, thereby making the cells highly sensitive to exogenous IL-2 from CD4(+) T helper cells.	G(M1) Ganglioside	43-46	interleukin 2	Homo sapiens	164-168
20173038-4	2010	Co-stimulation of FcepsilonRI and CCR1 with antigen and macrophage inflammatory protein-1alpha was more effective than FcepsilonRI stimulation alone in causing leading edge formation, flattened morphology, membrane ruffles and ganglioside (GM1(+)) lipid mediator release.	G(M1) Ganglioside	240-246	Fc epsilon receptor Ia	Homo sapiens	18-29
20173038-4	2010	Co-stimulation of FcepsilonRI and CCR1 with antigen and macrophage inflammatory protein-1alpha was more effective than FcepsilonRI stimulation alone in causing leading edge formation, flattened morphology, membrane ruffles and ganglioside (GM1(+)) lipid mediator release.	G(M1) Ganglioside	240-246	C-C motif chemokine receptor 1	Homo sapiens	34-38
20173038-4	2010	Co-stimulation of FcepsilonRI and CCR1 with antigen and macrophage inflammatory protein-1alpha was more effective than FcepsilonRI stimulation alone in causing leading edge formation, flattened morphology, membrane ruffles and ganglioside (GM1(+)) lipid mediator release.	G(M1) Ganglioside	240-246	C-C motif chemokine receptor 1	Homo sapiens	56-94
20025295-1	2010	The GM1/caveolin-1 lipid raft mediated endocytosis mechanism was explored for generation 5 and 7 poly(amidoamine) dendrimer polyplexes employing the Cos-7, 293A, C6, HeLa, KB, and HepG2 cell lines.	G(M1) Ganglioside	4-7	caveolin 1	Homo sapiens	8-18
20625494-0	2010	Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in Systemic Lupus Erythematosus patients.	G(M1) Ganglioside	36-39	CD4 molecule	Homo sapiens	54-57
20625494-0	2010	Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in Systemic Lupus Erythematosus patients.	G(M1) Ganglioside	36-39	TNF receptor superfamily member 8	Homo sapiens	94-98
20625494-2	2010	In this study we found that GM1 expression on CD4+ T cells and memory T cells (CD45RO/CD4) were dramatic increased after stimulation with phytohaemagglutinin in vitro.	G(M1) Ganglioside	28-31	CD4 molecule	Homo sapiens	46-49
20625494-2	2010	In this study we found that GM1 expression on CD4+ T cells and memory T cells (CD45RO/CD4) were dramatic increased after stimulation with phytohaemagglutinin in vitro.	G(M1) Ganglioside	28-31	CD4 molecule	Homo sapiens	79-82
20625494-3	2010	Next, we examined the GM1 expression on peripheral blood CD4+ T cells and CD8+ T cells from 44 patients with SLE and 28 healthy controls by flow cytometry.	G(M1) Ganglioside	22-25	CD4 molecule	Homo sapiens	57-60
20017804-6	2010	The ability of CTB to dramatically increase mucosal Ag uptake and presentation by different APCs through binding to GM1 ganglioside (which makes most B cells effective APCs irrespective of their Ag specificity), together with CTB-mediated stimulation of TGF-beta and IL-10 production and inhibition of IL-6 formation may explain the dramatic potentiation of oral tolerance by mucosal Ags presented with CTB.	G(M1) Ganglioside	116-131	phosphate cytidylyltransferase 1B, choline	Homo sapiens	15-18
20625494-4	2010	GM1 expression was further analyzed with serum soluble CD30 (sCD30), IL-10, TNF-alpha and clinical parameters.	G(M1) Ganglioside	0-3	TNF receptor superfamily member 8	Homo sapiens	55-59
20625494-4	2010	GM1 expression was further analyzed with serum soluble CD30 (sCD30), IL-10, TNF-alpha and clinical parameters.	G(M1) Ganglioside	0-3	interleukin 10	Homo sapiens	69-74
20625494-4	2010	GM1 expression was further analyzed with serum soluble CD30 (sCD30), IL-10, TNF-alpha and clinical parameters.	G(M1) Ganglioside	0-3	tumor necrosis factor	Homo sapiens	76-85
20625494-5	2010	The mean fluorescence intensity of GM1 on CD4+ T cells from patients with SLE was significantly higher than those from healthy controls, but not on CD8+ T cells.	G(M1) Ganglioside	35-38	CD4 molecule	Homo sapiens	42-45
20625494-6	2010	Increased expression of GM1 was more marked on CD4+/CD45RO+ memory T cells from active SLE patients.	G(M1) Ganglioside	24-27	CD4 molecule	Homo sapiens	47-50
20625494-8	2010	In addition, we found that enhanced GM1 expression on CD4+ T cells from patients with SLE positively correlated with high serum levels of sCD30 and IgG as well as disease activity (SLEDAI scores).	G(M1) Ganglioside	36-39	CD4 molecule	Homo sapiens	54-57
20625494-9	2010	Our data suggested the potential role of aberrant lipid raft/GM1 on CD4+ T cells and sCD30 in the pathogenesis of SLE.	G(M1) Ganglioside	61-64	CD4 molecule	Homo sapiens	68-71
19621257-0	2010	Protective and antioxidative effects of GM1 ganglioside in PC12 cells exposed to hydrogen peroxide are mediated by Trk tyrosine kinase.	G(M1) Ganglioside	40-55	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	115-118
19621257-1	2010	GM1 ganglioside was found to increase the survival of PC12 cells exposed to H(2)O(2), its action was blocked by Trk tyrosine kinase inhibitor K-252a.	G(M1) Ganglioside	0-15	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	112-115
19621257-6	2010	The protective and antioxidative effects of GM1 in PC12 cells exposed to H(2)O(2) appear to be mediated by activation of Trk receptor tyrosine kinase and the protein kinases downstream from this enzyme.	G(M1) Ganglioside	44-47	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	121-124
19657748-6	2010	Oral inoculation of mice with lyophilized transgenic rice calli containing LTB generated significant IgG antibody titers against bacterial LTB, and the sera of immunized mice inhibited the binding of bacterial LTB to G(M1)-ganglioside.	G(M1) Ganglioside	217-234	lymphotoxin B	Mus musculus	75-78
20017804-6	2010	The ability of CTB to dramatically increase mucosal Ag uptake and presentation by different APCs through binding to GM1 ganglioside (which makes most B cells effective APCs irrespective of their Ag specificity), together with CTB-mediated stimulation of TGF-beta and IL-10 production and inhibition of IL-6 formation may explain the dramatic potentiation of oral tolerance by mucosal Ags presented with CTB.	G(M1) Ganglioside	116-131	amyloid P component, serum	Homo sapiens	92-96
20017804-6	2010	The ability of CTB to dramatically increase mucosal Ag uptake and presentation by different APCs through binding to GM1 ganglioside (which makes most B cells effective APCs irrespective of their Ag specificity), together with CTB-mediated stimulation of TGF-beta and IL-10 production and inhibition of IL-6 formation may explain the dramatic potentiation of oral tolerance by mucosal Ags presented with CTB.	G(M1) Ganglioside	116-131	amyloid P component, serum	Homo sapiens	168-172
20017804-6	2010	The ability of CTB to dramatically increase mucosal Ag uptake and presentation by different APCs through binding to GM1 ganglioside (which makes most B cells effective APCs irrespective of their Ag specificity), together with CTB-mediated stimulation of TGF-beta and IL-10 production and inhibition of IL-6 formation may explain the dramatic potentiation of oral tolerance by mucosal Ags presented with CTB.	G(M1) Ganglioside	116-131	interleukin 10	Homo sapiens	267-272
19472408-1	2009	Alterations in GLB1, the gene coding for acid beta-D-galactosidase (beta-Gal), can result in GM1 gangliosidosis (GM1), a neurodegenerative disorder, or in Morquio B disease (MBD), a phenotype with dysostosis multiplex and normal central nervous system (CNS) function.	G(M1) Ganglioside	93-96	galactosidase beta 1	Homo sapiens	15-19
19849946-7	2009	RESULTS: High concentrations of GM1 (100 ng/L and 200 ng/L) promoted significantly the proliferation of NSCs in the medium containing EGF and bFGF (p<0.05).	G(M1) Ganglioside	32-35	epidermal growth factor	Homo sapiens	134-137
19849946-7	2009	RESULTS: High concentrations of GM1 (100 ng/L and 200 ng/L) promoted significantly the proliferation of NSCs in the medium containing EGF and bFGF (p<0.05).	G(M1) Ganglioside	32-35	fibroblast growth factor 2	Homo sapiens	142-146
19886192-0	2009	[Role of tyrosine kinase of Trk-receptors in realization of antioxidant effect of ganglioside GM1 in PC12 cells].	G(M1) Ganglioside	82-97	trunk	Drosophila melanogaster	28-31
19886192-2	2009	However, in the presence of inhibitor of tyroxine kinase Trk-receptors K-252a this GM1 effect decreases or virtually disappears.	G(M1) Ganglioside	83-86	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	57-60
19886192-5	2009	It has been found that inhibitors of each of protein kinases present at the signal realization stages following the stages of activation of tyrosine kinase Trk-receptors--Erk 1/2, PI3-kinases, and PKC, decreased the GM1 ability to reduce the H2O2-induced ROS accumulation, while in the combined use of inhibitors of these three protein kinases, the GM1 effect was completely absent.	G(M1) Ganglioside	216-219	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	156-159
19886192-5	2009	It has been found that inhibitors of each of protein kinases present at the signal realization stages following the stages of activation of tyrosine kinase Trk-receptors--Erk 1/2, PI3-kinases, and PKC, decreased the GM1 ability to reduce the H2O2-induced ROS accumulation, while in the combined use of inhibitors of these three protein kinases, the GM1 effect was completely absent.	G(M1) Ganglioside	216-219	WAP four-disulfide core domain 15B	Rattus norvegicus	180-183
19886192-5	2009	It has been found that inhibitors of each of protein kinases present at the signal realization stages following the stages of activation of tyrosine kinase Trk-receptors--Erk 1/2, PI3-kinases, and PKC, decreased the GM1 ability to reduce the H2O2-induced ROS accumulation, while in the combined use of inhibitors of these three protein kinases, the GM1 effect was completely absent.	G(M1) Ganglioside	349-352	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	156-159
19886192-5	2009	It has been found that inhibitors of each of protein kinases present at the signal realization stages following the stages of activation of tyrosine kinase Trk-receptors--Erk 1/2, PI3-kinases, and PKC, decreased the GM1 ability to reduce the H2O2-induced ROS accumulation, while in the combined use of inhibitors of these three protein kinases, the GM1 effect was completely absent.	G(M1) Ganglioside	349-352	WAP four-disulfide core domain 15B	Rattus norvegicus	180-183
19886192-6	2009	Thus, the ganglioside GM1 antioxidant effect on PC12 is mediated by activation of tyrosine kinase Trk-receptors and protein kinases perceiving signal from this enzyme.	G(M1) Ganglioside	22-25	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	98-101
19560125-0	2009	Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates.	G(M1) Ganglioside	89-92	galanin and GMAP prepropeptide	Homo sapiens	144-148
19837094-5	2009	Stronger T-cell responses were detected if a modified CTB molecule (mCTB) with reduced binding to GM1 ganglioside was used for cell stimulation compared to normal CTB.	G(M1) Ganglioside	98-113	phosphate cytidylyltransferase 1B, choline	Homo sapiens	54-57
19837094-5	2009	Stronger T-cell responses were detected if a modified CTB molecule (mCTB) with reduced binding to GM1 ganglioside was used for cell stimulation compared to normal CTB.	G(M1) Ganglioside	98-113	phosphate cytidylyltransferase 1B, choline	Homo sapiens	69-72
19052862-1	2009	Growing evidence has indicated that GM1 ganglioside specifically interacts with Amyloid beta-peptide (Abeta) and thereby promotes Alzheimer"s disease-associated Abeta assembly.	G(M1) Ganglioside	36-51	amyloid beta precursor protein	Homo sapiens	102-107
19052862-1	2009	Growing evidence has indicated that GM1 ganglioside specifically interacts with Amyloid beta-peptide (Abeta) and thereby promotes Alzheimer"s disease-associated Abeta assembly.	G(M1) Ganglioside	36-51	amyloid beta precursor protein	Homo sapiens	161-166
19052862-2	2009	To characterize the conformation of Abeta bound to the ganglioside, we performed 920 MHz ultra-high field NMR analyses using isotopically labeled Abeta(1-40) in association with GM1 and lyso-GM1 micelles.	G(M1) Ganglioside	178-181	amyloid beta precursor protein	Homo sapiens	36-41
19052862-2	2009	To characterize the conformation of Abeta bound to the ganglioside, we performed 920 MHz ultra-high field NMR analyses using isotopically labeled Abeta(1-40) in association with GM1 and lyso-GM1 micelles.	G(M1) Ganglioside	178-181	amyloid beta precursor protein	Homo sapiens	146-151
19450596-9	2009	In NHE3(-/-) mice, broad-spectrum oral antibiotics or anti-asialo GM1 antibodies reduce the expression of IFN-gamma and iNOS to basal levels and delay but do not prevent severe mortality in response to DSS treatment.	G(M1) Ganglioside	66-69	interferon gamma	Mus musculus	106-115
19450596-9	2009	In NHE3(-/-) mice, broad-spectrum oral antibiotics or anti-asialo GM1 antibodies reduce the expression of IFN-gamma and iNOS to basal levels and delay but do not prevent severe mortality in response to DSS treatment.	G(M1) Ganglioside	66-69	nitric oxide synthase 2, inducible	Mus musculus	120-124
19438805-1	2009	Ganglioside GM1-bound cholera toxin-B sub-unit (CT-b) enters the cell via clathrin-coated pits and dynamin-independent non-caveolar raft-dependent endocytosis.	G(M1) Ganglioside	12-15	phosphate cytidylyltransferase 1B, choline	Homo sapiens	22-46
19438805-1	2009	Ganglioside GM1-bound cholera toxin-B sub-unit (CT-b) enters the cell via clathrin-coated pits and dynamin-independent non-caveolar raft-dependent endocytosis.	G(M1) Ganglioside	12-15	phosphate cytidylyltransferase 1B, choline	Homo sapiens	48-52
18077059-2	2009	Previous study has demonstrated that ganglioside GM1 inhibits the secretion of APPs; however the underlying mechanism remains unknown.	G(M1) Ganglioside	37-52	cathepsin B	Homo sapiens	79-83
18077059-3	2009	Here we reported that GM1 can bind cellular full length APP and APPs secreted from APP(695) stably-transfected SH-SY5Y cells.	G(M1) Ganglioside	22-25	cathepsin B	Homo sapiens	64-68
19525014-2	2009	We found that anti-GM1 antibody (Ab) enhances TLR4 expression in Schwann"s cells (SCs) in vivo and in vitro.	G(M1) Ganglioside	19-22	toll like receptor 4	Homo sapiens	46-50
19445898-4	2009	In addition, caveolin-1 and GM1, lipid raft landmarkers, were internalized within cells after exposure to Rh2, indicating that Rh2 might disrupt lipid rafts.	G(M1) Ganglioside	28-31	Rh associated glycoprotein	Homo sapiens	106-109
19445898-4	2009	In addition, caveolin-1 and GM1, lipid raft landmarkers, were internalized within cells after exposure to Rh2, indicating that Rh2 might disrupt lipid rafts.	G(M1) Ganglioside	28-31	Rh associated glycoprotein	Homo sapiens	127-130
19525014-3	2009	The anti-GM1 Ab-treated SC also showed increased release of pro-inflammation cytokines IL-1beta and TNF-alpha after incubation with lipopolysaccharide (LPS).	G(M1) Ganglioside	9-12	interleukin 1 beta	Homo sapiens	87-95
19525014-3	2009	The anti-GM1 Ab-treated SC also showed increased release of pro-inflammation cytokines IL-1beta and TNF-alpha after incubation with lipopolysaccharide (LPS).	G(M1) Ganglioside	9-12	tumor necrosis factor	Homo sapiens	100-109
19451651-6	2009	Upon laminin treatment AQP4 and the dystrophin complex, including dystroglycan, reorganized into laminin-associated clusters enriched for the lipid raft markers GM1 and flotillin-1 but not caveolin-1.	G(M1) Ganglioside	161-164	dystrophin	Homo sapiens	36-46
19451651-6	2009	Upon laminin treatment AQP4 and the dystrophin complex, including dystroglycan, reorganized into laminin-associated clusters enriched for the lipid raft markers GM1 and flotillin-1 but not caveolin-1.	G(M1) Ganglioside	161-164	dystroglycan 1	Homo sapiens	66-78
19451651-8	2009	In addition, both cholesterol depletion and dystroglycan silencing reduced the number and area of laminin-induced clusters of GM1, AQP4, and dystroglycan.	G(M1) Ganglioside	126-129	dystroglycan 1	Homo sapiens	44-56
19641732-3	2009	We have previously used fluorescence lifetime imaging microscopy to study the colocalization of the receptor for EGF with the ganglioside GM1 and the GPI-anchored green fluorescent protein.	G(M1) Ganglioside	138-141	epidermal growth factor	Homo sapiens	113-116
20355927-4	2009	Cholera toxin subunit b (CTb) bound to an array of poly(lipid) bilayers doped with GM(1), and the extent of binding was correlated to the mole percentage of GM(1) in each spot.	G(M1) Ganglioside	83-88	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-23
20355927-4	2009	Cholera toxin subunit b (CTb) bound to an array of poly(lipid) bilayers doped with GM(1), and the extent of binding was correlated to the mole percentage of GM(1) in each spot.	G(M1) Ganglioside	83-88	phosphate cytidylyltransferase 1B, choline	Homo sapiens	25-28
20355927-6	2009	Poly(bis-SorbPC)/GM(1) arrays retained specific CTb binding capacity after multiple regenerations with a protein denaturing solution and also after exposure to air.	G(M1) Ganglioside	17-22	phosphate cytidylyltransferase 1B, choline	Homo sapiens	48-51
19380734-5	2009	A close association between specific GSL changes and EMT processes induced by EtDO-P4 or TGF-beta is indicated by the following findings: (i) The enhanced cell motility of EtDO-P4-treated cells was abrogated by exogenous addition of GM2 or Gg4, but not GM1 or GM3, in all 3 cell lines.	G(M1) Ganglioside	253-256	IL2 inducible T cell kinase	Mus musculus	53-56
19380734-5	2009	A close association between specific GSL changes and EMT processes induced by EtDO-P4 or TGF-beta is indicated by the following findings: (i) The enhanced cell motility of EtDO-P4-treated cells was abrogated by exogenous addition of GM2 or Gg4, but not GM1 or GM3, in all 3 cell lines.	G(M1) Ganglioside	253-256	decapentaplegic	Drosophila melanogaster	89-97
19641732-4	2009	Here we have used this technology to study the effect of EGF on the organization of GM1 in the plasma membrane.	G(M1) Ganglioside	84-87	epidermal growth factor	Homo sapiens	57-60
19641732-5	2009	Our data show that stimulation of the cell with EGF induces rapidly a strong increase in colocalization of GM1 molecules, suggesting the formation of large lipid domains.	G(M1) Ganglioside	107-110	epidermal growth factor	Homo sapiens	48-51
19133317-6	2009	The expression of GAP43 mRNA in Glu plus GM1 and NGF incubated neurons was the highest as compared with that in other groups.	G(M1) Ganglioside	41-44	growth associated protein 43	Rattus norvegicus	18-23
19139760-4	2009	We found that clustering GM1 lipid rafts can regulate beta1 integrin function.	G(M1) Ganglioside	25-28	myospheroid	Drosophila melanogaster	54-68
19139760-6	2009	Adhesion strengthening as a result of clustering GM1 enriched lipid rafts correlated with increased cellular rigidity and morphology through the localization of cortical F-actin, the resistance to shear-induced cell stretching, and an increase in the surface area and symmetry of the contact area between the cell surface and adhesive substrate.	G(M1) Ganglioside	49-52	Actin 79B	Drosophila melanogaster	170-177
19089660-3	2009	The biological activity of the purified recombinant LTB was assayed in a series of monosialotetrahexosylganglioside (GM1)-ELISA experiments.	G(M1) Ganglioside	83-115	lymphotoxin beta	Rattus norvegicus	52-55
19109948-7	2009	Isolation of detergent-resistant membrane fragments by Optiprep-gradient density indicated that this pool of PP2A was not associated with caveolae, but was recovered in a higher density fraction (DRM-H) with ganglioside GM1, alpha-actinin, Hsp27 and p34, a component of Arp2/3 complex.	G(M1) Ganglioside	208-223	protein phosphatase 2 phosphatase activator	Homo sapiens	109-113
19138679-4	2009	The ganglioside GM1 potentiated the effect of Abeta (1-40), as viewed from (31)P NMR.	G(M1) Ganglioside	16-19	amyloid beta precursor protein	Homo sapiens	46-51
19138679-5	2009	The difference of the isotropic peak intensity between DMPC/Abeta and DMPC/GM1/Abeta suggests a specific interaction between Abeta and GM1.	G(M1) Ganglioside	75-78	amyloid beta precursor protein	Homo sapiens	79-84
19138679-5	2009	The difference of the isotropic peak intensity between DMPC/Abeta and DMPC/GM1/Abeta suggests a specific interaction between Abeta and GM1.	G(M1) Ganglioside	75-78	amyloid beta precursor protein	Homo sapiens	79-84
19138679-5	2009	The difference of the isotropic peak intensity between DMPC/Abeta and DMPC/GM1/Abeta suggests a specific interaction between Abeta and GM1.	G(M1) Ganglioside	135-138	amyloid beta precursor protein	Homo sapiens	60-65
19138679-5	2009	The difference of the isotropic peak intensity between DMPC/Abeta and DMPC/GM1/Abeta suggests a specific interaction between Abeta and GM1.	G(M1) Ganglioside	135-138	amyloid beta precursor protein	Homo sapiens	79-84
19138679-5	2009	The difference of the isotropic peak intensity between DMPC/Abeta and DMPC/GM1/Abeta suggests a specific interaction between Abeta and GM1.	G(M1) Ganglioside	135-138	amyloid beta precursor protein	Homo sapiens	79-84
19138679-6	2009	We show that in the DMPC/GM1/Abeta system there are three lipid phases, namely a lamellar phase, a hexagonal phase and non-oriented lipids.	G(M1) Ganglioside	25-28	amyloid beta precursor protein	Homo sapiens	29-34
19089660-3	2009	The biological activity of the purified recombinant LTB was assayed in a series of monosialotetrahexosylganglioside (GM1)-ELISA experiments.	G(M1) Ganglioside	117-120	lymphotoxin beta	Rattus norvegicus	52-55
19089660-6	2009	GM1-ELISA experiments showed that the rLTB obtained retains strong GM1 ganglioside-binding activity.	G(M1) Ganglioside	0-3	lymphotoxin beta	Rattus norvegicus	38-42
19089660-6	2009	GM1-ELISA experiments showed that the rLTB obtained retains strong GM1 ganglioside-binding activity.	G(M1) Ganglioside	67-82	lymphotoxin beta	Rattus norvegicus	38-42
18950789-5	2009	Cholera toxin subunit B (CTB) was used to detect the presence of GM1 on the formed layers.	G(M1) Ganglioside	65-68	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-23
19037902-5	2009	Virtually all of the CTB-MPR(649-684) proteins expressed in the selected line were shown to have assembled into pentameric, GM1 ganglioside-binding complexes.	G(M1) Ganglioside	124-139	chitobiase	Homo sapiens	21-24
18950789-5	2009	Cholera toxin subunit B (CTB) was used to detect the presence of GM1 on the formed layers.	G(M1) Ganglioside	65-68	phosphate cytidylyltransferase 1B, choline	Homo sapiens	25-28
18950789-9	2009	Adsorption of CTB was found to be proportional to the amount of GM1 present in the liposomes.	G(M1) Ganglioside	64-67	phosphate cytidylyltransferase 1B, choline	Homo sapiens	14-17
18478327-9	2009	These results suggest that in some case of GBS, particularly of AMAN patients with IgG anti-GM1 mAb, muscle weakness may be induced by dysfunction of Cav2.1 VDCC functioning at the motor nerve terminals.	G(M1) Ganglioside	92-95	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	150-156
19118221-0	2009	Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth.	G(M1) Ganglioside	45-48	laminin subunit alpha 1	Rattus norvegicus	11-20
19118221-2	2009	Monosialoganglioside GM1 in the lipid rafts associates with and activates the NGF receptor TrkA, and enhances neurite outgrowth.	G(M1) Ganglioside	0-24	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	91-95
19118221-4	2009	Here, we describe that laminin-1 binds to GM1 through a carbohydrate moiety and a specific conformation of GM1, induces focal formation of large clusters of GM1, and enhances the relocation of TrkA in the membrane of dorsal root ganglion (DRG) and PC12 cells.	G(M1) Ganglioside	42-45	laminin subunit alpha 1	Rattus norvegicus	23-32
19118221-4	2009	Here, we describe that laminin-1 binds to GM1 through a carbohydrate moiety and a specific conformation of GM1, induces focal formation of large clusters of GM1, and enhances the relocation of TrkA in the membrane of dorsal root ganglion (DRG) and PC12 cells.	G(M1) Ganglioside	42-45	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	193-197
19118221-4	2009	Here, we describe that laminin-1 binds to GM1 through a carbohydrate moiety and a specific conformation of GM1, induces focal formation of large clusters of GM1, and enhances the relocation of TrkA in the membrane of dorsal root ganglion (DRG) and PC12 cells.	G(M1) Ganglioside	107-110	laminin subunit alpha 1	Rattus norvegicus	23-32
19118221-4	2009	Here, we describe that laminin-1 binds to GM1 through a carbohydrate moiety and a specific conformation of GM1, induces focal formation of large clusters of GM1, and enhances the relocation of TrkA in the membrane of dorsal root ganglion (DRG) and PC12 cells.	G(M1) Ganglioside	107-110	laminin subunit alpha 1	Rattus norvegicus	23-32
19118221-5	2009	We found that laminin-1-mediated clustering of GM1 causes the translocation and enrichment of beta1 integrin in lipid rafts--where TrkA colocalizes with beta1 integrin--and the activation of Lyn, Akt and MAPK to promote the outgrowth of neurites.	G(M1) Ganglioside	47-50	laminin subunit alpha 1	Rattus norvegicus	14-23
19118221-5	2009	We found that laminin-1-mediated clustering of GM1 causes the translocation and enrichment of beta1 integrin in lipid rafts--where TrkA colocalizes with beta1 integrin--and the activation of Lyn, Akt and MAPK to promote the outgrowth of neurites.	G(M1) Ganglioside	47-50	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	131-135
19118221-5	2009	We found that laminin-1-mediated clustering of GM1 causes the translocation and enrichment of beta1 integrin in lipid rafts--where TrkA colocalizes with beta1 integrin--and the activation of Lyn, Akt and MAPK to promote the outgrowth of neurites.	G(M1) Ganglioside	47-50	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	191-194
19118221-5	2009	We found that laminin-1-mediated clustering of GM1 causes the translocation and enrichment of beta1 integrin in lipid rafts--where TrkA colocalizes with beta1 integrin--and the activation of Lyn, Akt and MAPK to promote the outgrowth of neurites.	G(M1) Ganglioside	47-50	AKT serine/threonine kinase 1	Rattus norvegicus	196-199
19118221-6	2009	Our results suggest that the binding of laminin-1 to GM1 facilitates the formation of a focal microdomain in the membrane, and enhances signal transduction that promotes neurite outgrowth by linking NGF-TrkA signaling with the laminin-integrin signaling pathways.	G(M1) Ganglioside	53-56	laminin subunit alpha 1	Rattus norvegicus	40-49
19118221-6	2009	Our results suggest that the binding of laminin-1 to GM1 facilitates the formation of a focal microdomain in the membrane, and enhances signal transduction that promotes neurite outgrowth by linking NGF-TrkA signaling with the laminin-integrin signaling pathways.	G(M1) Ganglioside	53-56	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	203-207
19404395-6	2009	Importantly, our fluorescence-topographic NSOM imaging demonstrated that GM1/CD59 raft markers distributed and re-distributed at mounds but not depressions of T-cell membrane fluctuations.	G(M1) Ganglioside	73-76	CD59 molecule (CD59 blood group)	Homo sapiens	77-81
18764920-6	2009	GM1-ELISA revealed that the LTB-ST fusion protein retained its oligomeric structure, and displayed antigenic determinants for both LTB and ST. Western blot analysis, using LTB antisera, confirmed the presence of a 17-KDa protein in transplastomic lines, with the correct antigenicity of the fusion protein.	G(M1) Ganglioside	0-3	lymphotoxin B	Mus musculus	28-31
19337375-8	2009	We first identified PrP(C) in association with the lipid raft components Fyn, flotillin-2, GM1 and GM3 in MVs from plasma of healthy human donors.	G(M1) Ganglioside	91-94	prion protein	Homo sapiens	20-26
18753612-10	2008	Thus, ganglioside GM1 is a receptor of SVS2 and plays a crucial role in capacitation in vivo.	G(M1) Ganglioside	6-21	semenogelin 1	Mus musculus	39-43
18930716-0	2008	GM1 induces p38 and microtubule dependent ramification of rat primary microglia in vitro.	G(M1) Ganglioside	0-3	mitogen activated protein kinase 14	Rattus norvegicus	12-15
18930716-5	2008	Although GM1 significantly induced the expression of neurotrophin-3 (NT-3), NT-3 did not induce typical morphological changes in cultured rat primary microglia.	G(M1) Ganglioside	9-12	neurotrophin 3	Rattus norvegicus	53-67
19356099-1	2008	We studied endogenous substrates for P-glycoprotein (P-gp) in an oxidative reaction mixture of ceramides, phospholipids, sphingolipids, or GM1-gangliosides (GM1-G).	G(M1) Ganglioside	139-155	ATP binding cassette subfamily B member 1	Homo sapiens	37-51
18753612-0	2008	Ganglioside GM1 mediates decapacitation effects of SVS2 on murine spermatozoa.	G(M1) Ganglioside	12-15	semenogelin 1	Mus musculus	51-55
18753612-6	2008	When the ejaculated spermatozoa were stained with a cholera toxin subunit B (CTB) that preferably interacts with ganglioside GM1, another member of the lipid rafts, the staining pattern of the sperm was the same as the binding pattern of SVS2.	G(M1) Ganglioside	125-128	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	52-75
18753612-6	2008	When the ejaculated spermatozoa were stained with a cholera toxin subunit B (CTB) that preferably interacts with ganglioside GM1, another member of the lipid rafts, the staining pattern of the sperm was the same as the binding pattern of SVS2.	G(M1) Ganglioside	125-128	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	77-80
18753612-7	2008	Interestingly, SVS2 and CTB competitively bound to the sperm surface with each other, suggesting that the binding targets of both molecules are the same, that is, GM1.	G(M1) Ganglioside	163-166	semenogelin 1	Mus musculus	15-19
18753612-7	2008	Interestingly, SVS2 and CTB competitively bound to the sperm surface with each other, suggesting that the binding targets of both molecules are the same, that is, GM1.	G(M1) Ganglioside	163-166	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	24-27
18753612-8	2008	Molecular interaction studies by the overlay assay and the quartz crystal microbalance analysis revealed that SVS2 selectively interacts with GM1 rather than with other gangliosides.	G(M1) Ganglioside	142-145	semenogelin 1	Mus musculus	110-114
18753612-9	2008	Furthermore, external addition of GM1 nullified SVS2-induced sperm decapacitation.	G(M1) Ganglioside	34-37	semenogelin 1	Mus musculus	48-52
19356099-1	2008	We studied endogenous substrates for P-glycoprotein (P-gp) in an oxidative reaction mixture of ceramides, phospholipids, sphingolipids, or GM1-gangliosides (GM1-G).	G(M1) Ganglioside	139-155	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
19356099-1	2008	We studied endogenous substrates for P-glycoprotein (P-gp) in an oxidative reaction mixture of ceramides, phospholipids, sphingolipids, or GM1-gangliosides (GM1-G).	G(M1) Ganglioside	157-162	ATP binding cassette subfamily B member 1	Homo sapiens	37-51
19356099-1	2008	We studied endogenous substrates for P-glycoprotein (P-gp) in an oxidative reaction mixture of ceramides, phospholipids, sphingolipids, or GM1-gangliosides (GM1-G).	G(M1) Ganglioside	157-162	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
18570383-7	2008	Therefore, the binding of GM1 with pentameric cholera toxin B (CTB) subunits could be probed.	G(M1) Ganglioside	26-29	phosphate cytidylyltransferase 1B, choline	Homo sapiens	63-66
18579701-9	2008	In parallel, increased colocalization of NKCC2 with the LR ganglioside GM1 and their polar translocation were assessed by confocal analysis.	G(M1) Ganglioside	71-74	solute carrier family 12 member 1	Rattus norvegicus	41-46
18692507-0	2008	Formation of toxic Abeta(1-40) fibrils on GM1 ganglioside-containing membranes mimicking lipid rafts: polymorphisms in Abeta(1-40) fibrils.	G(M1) Ganglioside	42-57	amyloid beta precursor protein	Rattus norvegicus	19-24
18692507-4	2008	Here, we identified toxic Abeta(1-40) aggregates formed with GM1-ganglioside-containing membranes.	G(M1) Ganglioside	61-76	amyloid beta precursor protein	Rattus norvegicus	26-31
18692507-5	2008	Abeta(1-40) was incubated with raft-like liposomes composed of GM1/cholesterol/sphingomyelin at 1:2:2 and 37 degrees C. After a lag period, toxic amyloid fibrils with a width of 12 nm were formed and subsequently laterally assembled with slight changes in their secondary structure as confirmed by viability assay, thioflavin-T fluorescence, circular dichroism, and transmission electron microscopy.	G(M1) Ganglioside	63-66	amyloid beta precursor protein	Rattus norvegicus	0-5
18556353-7	2008	Spontaneous and stimulated rPRL discharge in live lactotrophs is thus associated with plasma membrane sites enriched with SNARE proteins, however, spatially confined to plasma membrane areas other than GM1 rafts.	G(M1) Ganglioside	202-205	prolactin	Rattus norvegicus	27-31
18796718-4	2008	Double immunofluorescence staining of infected HEK-293T cells revealed that NS1 localized with raft-associated molecules, ganglioside GM1 and CD55, on the cell surface.	G(M1) Ganglioside	134-137	influenza virus NS1A binding protein	Homo sapiens	76-79
18768683-4	2008	We show that activation of FGF receptor(s) by FGF2 leads to palmitoylation of the two major transmembrane NCAM isoforms, NCAM140 and NCAM180, translocation of NCAM to GM1 ganglioside-containing lipid rafts, and stimulation of neurite outgrowth of hippocampal neurons.	G(M1) Ganglioside	167-182	fibroblast growth factor 2	Homo sapiens	46-50
18768683-4	2008	We show that activation of FGF receptor(s) by FGF2 leads to palmitoylation of the two major transmembrane NCAM isoforms, NCAM140 and NCAM180, translocation of NCAM to GM1 ganglioside-containing lipid rafts, and stimulation of neurite outgrowth of hippocampal neurons.	G(M1) Ganglioside	167-182	neural cell adhesion molecule 1	Homo sapiens	106-110
18695048-0	2008	The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1.	G(M1) Ganglioside	79-82	C-terminal Src kinase	Drosophila melanogaster	4-7
18695048-0	2008	The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1.	G(M1) Ganglioside	79-82	Src oncogene at 64B	Drosophila melanogaster	51-54
18767553-0	2008	[A decrease of neuroprotector effect of ganglioside GM1 on PC12 cells under conditions of oxidative stress in the presence of inhibitor of tyrosine kinase of Trk-receptors].	G(M1) Ganglioside	40-55	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	158-161
18581052-0	2008	Co-localization of galectin-1 with GM1 ganglioside in the course of its clathrin- and raft-dependent endocytosis.	G(M1) Ganglioside	35-50	galectin 1	Homo sapiens	19-29
18581052-6	2008	Based on their strong intracellular co-localization, two glycoconjugates, GM1 ganglioside and CD7 are implicated in the sorting of internalized Gal-1 into Golgi.	G(M1) Ganglioside	74-89	galectin 1	Homo sapiens	144-149
18664873-0	2008	Coincidental GM1 gangliosidosis in an infant with alpha-1-antitrypsin deficiency.	G(M1) Ganglioside	13-16	serpin family A member 1	Homo sapiens	50-69
18767553-8	2008	Thus, inhibitor of tyrosine kinase of Trk-receptors K-252 decreases or practically prevents the ganglioside GM1 neuroprotective effect of PC12 cells under stress conditions; the same ability is characteristic of genistein--an inhibitor of tyrosine kinases of the wider spectrum of action.	G(M1) Ganglioside	108-111	trunk	Drosophila melanogaster	38-41
18274892-1	2008	GM1 epitope tetrasaccharide was synthesized by a condensation of sialyl-alpha(2-3)-gal acceptor and gal-beta(1-3)-GalN donor in a highly efficient manner.	G(M1) Ganglioside	0-3	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	104-112
18274892-1	2008	GM1 epitope tetrasaccharide was synthesized by a condensation of sialyl-alpha(2-3)-gal acceptor and gal-beta(1-3)-GalN donor in a highly efficient manner.	G(M1) Ganglioside	0-3	galanin and GMAP prepropeptide	Homo sapiens	114-118
18400513-9	2008	Soluble LTB in the E. coli lysate was also purified by Ni2+-chelating affinity chromatography and the assembled pentamer was able to bind with high affinity to GM1 in vitro.	G(M1) Ganglioside	160-163	lymphotoxin beta	Rattus norvegicus	8-11
18421424-1	2008	Lysosomal beta-galactosidase is required for the degradation of GM1 ganglioside and other glycolipids and glycoproteins with a terminal galactose moiety.	G(M1) Ganglioside	64-79	beta-galactosidase	Cricetulus griseus	10-28
18421424-4	2008	The enzyme secreted into culture medium exhibited specific activity on two synthetic substrates as well as on the native beta-galactosidase substrate, GM1 ganglioside.	G(M1) Ganglioside	151-166	beta-galactosidase	Cricetulus griseus	121-139
18334715-5	2008	Abeta undergoes a conformational transition from random coil to ordered structure rich in beta-sheets, especially after addition of lipid vesicles containing GM1 ganglioside.	G(M1) Ganglioside	158-173	amyloid beta precursor protein	Homo sapiens	0-5
18235103-5	2008	Our results indicate that: 1) the sperm-associated proteins, P25b and adenylate kinase 1, are linked to DRM of epididymal spermatozoa, but were exclusively associated with detergent-soluble material in ejaculated spermatozoa; 2) seminal plasma treatment of cauda epididymal spermatozoa significantly lowered the content of cholesterol and the ganglioside, GM1, in DRM; and 3), seminal plasma dissociates P25b from DRM in epididymal spermatozoa.	G(M1) Ganglioside	356-359	P25B	Bos taurus	61-65
18416535-1	2008	The influence of membrane lipid environment on the activity of GPI-anchored enzymes was investigated with human placental alkaline phosphatase reconstituted by a detergent-dialysis technique in liposomes composed of palmitoyloleoylphosphatidylcholine, alone or in mixture with lipids enriched along with the protein within lipid rafts: cholesterol, sphingomyelin, and GM1 ganglioside.	G(M1) Ganglioside	368-383	glucose-6-phosphate isomerase	Homo sapiens	63-66
18235103-5	2008	Our results indicate that: 1) the sperm-associated proteins, P25b and adenylate kinase 1, are linked to DRM of epididymal spermatozoa, but were exclusively associated with detergent-soluble material in ejaculated spermatozoa; 2) seminal plasma treatment of cauda epididymal spermatozoa significantly lowered the content of cholesterol and the ganglioside, GM1, in DRM; and 3), seminal plasma dissociates P25b from DRM in epididymal spermatozoa.	G(M1) Ganglioside	356-359	adenylate kinase 1	Bos taurus	70-88
18235103-6	2008	We found that the seminal plasma protein, Niemann-Pick C2 protein, is involved in cholesterol and GM1 depletion within DRM, then leading to membrane redistribution of P25b that occurs in a very rapid and capacitation-independent manner.	G(M1) Ganglioside	98-101	P25B	Bos taurus	167-171
18329889-5	2008	Our results suggest that GM1 administration to female NOD mice beginning at the 4th week of life is able to reduce the index of inflammatory infiltrate and consequently the expression of diabetes, modulating the expression of proinflammatory cytokines (IL-12, IFN-gamma, TNF-alpha and IL-1beta).	G(M1) Ganglioside	25-28	interferon gamma	Mus musculus	260-269
18473785-5	2008	The fusion protein"s affinity to GM1 ganglioside was comparable to that of native CTB.	G(M1) Ganglioside	33-48	phosphate cytidylyltransferase 1B, choline	Homo sapiens	82-85
18392450-0	2008	Transient high-level expression of beta-galactosidase after transfection of fibroblasts from GM1 gangliosidosis patients with plasmid DNA.	G(M1) Ganglioside	93-96	galactosidase beta 1	Homo sapiens	35-53
18392450-1	2008	GM1 gangliosidosis is an autosomal recessive disorder caused by the deficiency of lysosomal acid hydrolase beta-galactosidase (beta-Gal).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	107-125
18392450-1	2008	GM1 gangliosidosis is an autosomal recessive disorder caused by the deficiency of lysosomal acid hydrolase beta-galactosidase (beta-Gal).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	127-135
18081725-6	2008	Bacteria-engaged CEACAM1-4L and CEACAM1 DeltaCT, but not CEACAM3, localize to a gangliosid GM1- and GPI-anchored protein-containing portion of the plasma membrane.	G(M1) Ganglioside	91-94	CEA cell adhesion molecule 1	Homo sapiens	17-24
18081725-6	2008	Bacteria-engaged CEACAM1-4L and CEACAM1 DeltaCT, but not CEACAM3, localize to a gangliosid GM1- and GPI-anchored protein-containing portion of the plasma membrane.	G(M1) Ganglioside	91-94	CEA cell adhesion molecule 1	Homo sapiens	32-39
18316074-6	2008	The plasma membrane Src pool did not colocalize with caveolin-1 and flotillin-2, but extensively overlapped GM1 labelling by cholera toxin.	G(M1) Ganglioside	108-111	SRC proto-oncogene, non-receptor tyrosine kinase	Canis lupus familiaris	20-23
18382692-5	2008	Herein, global lipid profiling demonstrates that Hsp70 membrane-positive tumors differ from their membrane-negative counterparts by containing significantly higher amounts of globotriaoslyceramide (Gb3), but not of other lipids such as lactosylceramide (LacCer), dodecasaccharideceramide (DoCer), galactosylceramide (GalCer), ceramide (Cer), or the ganglioside GM1.	G(M1) Ganglioside	361-364	Heat-shock-protein-70Ab	Drosophila melanogaster	49-54
18329889-0	2008	Ganglioside GM1 effects on the expression of nerve growth factor (NGF), Trk-A receptor, proinflammatory cytokines and on autoimmune diabetes onset in non-obese diabetic (NOD) mice.	G(M1) Ganglioside	12-15	nerve growth factor	Mus musculus	45-64
18329889-0	2008	Ganglioside GM1 effects on the expression of nerve growth factor (NGF), Trk-A receptor, proinflammatory cytokines and on autoimmune diabetes onset in non-obese diabetic (NOD) mice.	G(M1) Ganglioside	12-15	nerve growth factor	Mus musculus	66-69
18329889-5	2008	Our results suggest that GM1 administration to female NOD mice beginning at the 4th week of life is able to reduce the index of inflammatory infiltrate and consequently the expression of diabetes, modulating the expression of proinflammatory cytokines (IL-12, IFN-gamma, TNF-alpha and IL-1beta).	G(M1) Ganglioside	25-28	tumor necrosis factor	Mus musculus	271-280
18329889-5	2008	Our results suggest that GM1 administration to female NOD mice beginning at the 4th week of life is able to reduce the index of inflammatory infiltrate and consequently the expression of diabetes, modulating the expression of proinflammatory cytokines (IL-12, IFN-gamma, TNF-alpha and IL-1beta).	G(M1) Ganglioside	25-28	interleukin 1 beta	Mus musculus	285-293
18329889-6	2008	Furthermore, GM1 increases GFAP, S-100beta and NGF in pancreas islets, factors involved in beta cell survival.	G(M1) Ganglioside	13-16	glial fibrillary acidic protein	Mus musculus	27-31
18329889-6	2008	Furthermore, GM1 increases GFAP, S-100beta and NGF in pancreas islets, factors involved in beta cell survival.	G(M1) Ganglioside	13-16	S100 protein, beta polypeptide, neural	Mus musculus	33-42
18329889-6	2008	Furthermore, GM1 increases GFAP, S-100beta and NGF in pancreas islets, factors involved in beta cell survival.	G(M1) Ganglioside	13-16	nerve growth factor	Mus musculus	47-50
18428041-3	2008	We have studied by fluorescence microscopy cross-linking of ganglioside GM1 in the human erythrocyte membrane, and how membrane proteins CD47 and CD59 distribute in GM1 patched discoid cells and calcium-induced echinocytic cells.	G(M1) Ganglioside	165-168	CD47 molecule	Homo sapiens	137-141
18021298-4	2008	In the sucrose-density-gradient fractionation of cell media, GM1 ganglioside was exclusively recovered with Alix, a specific marker of exosomes, in the fractions with the density corrresponding to that of exosomes.	G(M1) Ganglioside	61-76	programmed cell death 6 interacting protein	Rattus norvegicus	108-112
18428041-3	2008	We have studied by fluorescence microscopy cross-linking of ganglioside GM1 in the human erythrocyte membrane, and how membrane proteins CD47 and CD59 distribute in GM1 patched discoid cells and calcium-induced echinocytic cells.	G(M1) Ganglioside	165-168	CD59 molecule (CD59 blood group)	Homo sapiens	146-150
18428041-4	2008	Patching of ganglioside(M1) (GM1) by cholera toxin subunit B (CTB) plus anti-CTB resulted in the formation of usually 40-60 GM1 patches distributed over the membrane in discoid erythrocytes.	G(M1) Ganglioside	29-32	phosphate cytidylyltransferase 1B, choline	Homo sapiens	77-80
18428041-4	2008	Patching of ganglioside(M1) (GM1) by cholera toxin subunit B (CTB) plus anti-CTB resulted in the formation of usually 40-60 GM1 patches distributed over the membrane in discoid erythrocytes.	G(M1) Ganglioside	29-32	phosphate cytidylyltransferase 1B, choline	Homo sapiens	62-65
17980152-3	2008	Rat MOR in CPu was found mainly associated with low-density cholesterol- and ganglioside M1 (GM1)-enriched membrane subdomains (lipid rafts), while the MOR in the thalamus was present in rafts and non-rafts without preference.	G(M1) Ganglioside	93-96	opioid receptor, mu 1	Mus musculus	4-7
18339884-3	2008	The synergy between tumor-derived TNFalpha and the RCC-overexpressed ganglioside GM1 for killing resting T cells is corroborated by studies using purified GM1 and rTNF alpha, which indicate that a 48-hour pretreatment with the ganglioside optimally sensitizes the lymphocytes to a TNFalpha-induced apoptotic death.	G(M1) Ganglioside	69-84	tumor necrosis factor	Rattus norvegicus	163-173
18339884-3	2008	The synergy between tumor-derived TNFalpha and the RCC-overexpressed ganglioside GM1 for killing resting T cells is corroborated by studies using purified GM1 and rTNF alpha, which indicate that a 48-hour pretreatment with the ganglioside optimally sensitizes the lymphocytes to a TNFalpha-induced apoptotic death.	G(M1) Ganglioside	69-84	eiger	Drosophila melanogaster	281-289
18339884-3	2008	The synergy between tumor-derived TNFalpha and the RCC-overexpressed ganglioside GM1 for killing resting T cells is corroborated by studies using purified GM1 and rTNF alpha, which indicate that a 48-hour pretreatment with the ganglioside optimally sensitizes the lymphocytes to a TNFalpha-induced apoptotic death.	G(M1) Ganglioside	81-84	tumor necrosis factor	Rattus norvegicus	163-173
18339884-3	2008	The synergy between tumor-derived TNFalpha and the RCC-overexpressed ganglioside GM1 for killing resting T cells is corroborated by studies using purified GM1 and rTNF alpha, which indicate that a 48-hour pretreatment with the ganglioside optimally sensitizes the lymphocytes to a TNFalpha-induced apoptotic death.	G(M1) Ganglioside	81-84	eiger	Drosophila melanogaster	281-289
18339884-4	2008	However, activated T cells, which synthesize TNFalpha themselves, can be killed by exogenous GM1 alone.	G(M1) Ganglioside	93-96	tumor necrosis factor	Homo sapiens	45-53
18339884-8	2008	This report thus extends our previous studies by demonstrating that tumor-derived TNFalpha enhances RCC apoptogenicity not only by inducing ganglioside synthesis but also by initiating receptor-dependent apoptosis in T cells in which the nuclear factor-kappaB activation pathway has been inhibited by GM1.	G(M1) Ganglioside	301-304	tumor necrosis factor	Homo sapiens	82-90
18163467-6	2008	GM1 gangliosides highly colocalized with GPI-linked protein markers of rafts and a new anti-cholesterol antibody (AC8) in various immune cells.	G(M1) Ganglioside	0-16	adenylate cyclase 8	Homo sapiens	114-117
18028334-0	2008	GM1-induced activation of phosphatidylinositol 3-kinase: involvement of Trk receptors.	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 1	Homo sapiens	72-75
18028334-2	2008	In brain, GM1 activates the Trk receptors for neurotrophins and the Raf/MEK/ERK cascade in situ and in vivo.	G(M1) Ganglioside	10-13	neurotrophic receptor tyrosine kinase 1	Homo sapiens	28-31
18028334-2	2008	In brain, GM1 activates the Trk receptors for neurotrophins and the Raf/MEK/ERK cascade in situ and in vivo.	G(M1) Ganglioside	10-13	zinc fingers and homeoboxes 2	Homo sapiens	68-71
18028334-2	2008	In brain, GM1 activates the Trk receptors for neurotrophins and the Raf/MEK/ERK cascade in situ and in vivo.	G(M1) Ganglioside	10-13	mitogen-activated protein kinase kinase 7	Homo sapiens	72-75
18028334-2	2008	In brain, GM1 activates the Trk receptors for neurotrophins and the Raf/MEK/ERK cascade in situ and in vivo.	G(M1) Ganglioside	10-13	mitogen-activated protein kinase 1	Homo sapiens	76-79
18028334-7	2008	PI3-kinase activity was found increased in Trk and Gab1 immunoprecipitates, and co-immunoprecipitation studies demonstrated the association of Trk and Gab1 after GM1 treatment.	G(M1) Ganglioside	162-165	neurotrophic receptor tyrosine kinase 1	Homo sapiens	143-146
18028334-7	2008	PI3-kinase activity was found increased in Trk and Gab1 immunoprecipitates, and co-immunoprecipitation studies demonstrated the association of Trk and Gab1 after GM1 treatment.	G(M1) Ganglioside	162-165	GRB2 associated binding protein 1	Homo sapiens	151-155
18028334-10	2008	Our findings suggest that GM1 induces activation of PI3-kinase that is, in part, mediated through Trk and Gab1.	G(M1) Ganglioside	26-29	neurotrophic receptor tyrosine kinase 1	Homo sapiens	98-101
18028334-10	2008	Our findings suggest that GM1 induces activation of PI3-kinase that is, in part, mediated through Trk and Gab1.	G(M1) Ganglioside	26-29	GRB2 associated binding protein 1	Homo sapiens	106-110
17907924-12	2008	Galectin-9-induced clustering of lipid rafts detected by cholera toxin B (CTB; binding the raft-resident ganglioside GM1) using confocal microscopy.	G(M1) Ganglioside	117-120	galectin 9	Homo sapiens	0-10
17907924-12	2008	Galectin-9-induced clustering of lipid rafts detected by cholera toxin B (CTB; binding the raft-resident ganglioside GM1) using confocal microscopy.	G(M1) Ganglioside	117-120	phosphate cytidylyltransferase 1B, choline	Homo sapiens	74-77
17907924-13	2008	Cross-linking of the GM1 ganglioside with CTB by anti-CTB antibody-induced phosphorylation of c-Src, whereas disruption of galectin-9-induced lipid rafts by beta-methylcyclodextrin reduced c-Src phosphorylation and proliferation of the cells.	G(M1) Ganglioside	21-36	phosphate cytidylyltransferase 1B, choline	Homo sapiens	42-45
17907924-13	2008	Cross-linking of the GM1 ganglioside with CTB by anti-CTB antibody-induced phosphorylation of c-Src, whereas disruption of galectin-9-induced lipid rafts by beta-methylcyclodextrin reduced c-Src phosphorylation and proliferation of the cells.	G(M1) Ganglioside	21-36	phosphate cytidylyltransferase 1B, choline	Homo sapiens	54-57
17907924-13	2008	Cross-linking of the GM1 ganglioside with CTB by anti-CTB antibody-induced phosphorylation of c-Src, whereas disruption of galectin-9-induced lipid rafts by beta-methylcyclodextrin reduced c-Src phosphorylation and proliferation of the cells.	G(M1) Ganglioside	21-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	94-99
17907924-13	2008	Cross-linking of the GM1 ganglioside with CTB by anti-CTB antibody-induced phosphorylation of c-Src, whereas disruption of galectin-9-induced lipid rafts by beta-methylcyclodextrin reduced c-Src phosphorylation and proliferation of the cells.	G(M1) Ganglioside	21-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	189-194
18428041-4	2008	Patching of ganglioside(M1) (GM1) by cholera toxin subunit B (CTB) plus anti-CTB resulted in the formation of usually 40-60 GM1 patches distributed over the membrane in discoid erythrocytes.	G(M1) Ganglioside	124-127	phosphate cytidylyltransferase 1B, choline	Homo sapiens	62-65
18428041-4	2008	Patching of ganglioside(M1) (GM1) by cholera toxin subunit B (CTB) plus anti-CTB resulted in the formation of usually 40-60 GM1 patches distributed over the membrane in discoid erythrocytes.	G(M1) Ganglioside	124-127	phosphate cytidylyltransferase 1B, choline	Homo sapiens	77-80
18428041-12	2008	However, CD59 showed a low degree of co-localization with GM1 and frequently accumulated in different spiculae than GM1.	G(M1) Ganglioside	58-61	CD59 molecule (CD59 blood group)	Homo sapiens	9-13
18207250-8	2008	With the use of confocal imaging, FcgammaRI was found to co-patch with GM1, a microdomain-enriched glycolipid.	G(M1) Ganglioside	71-74	Fc gamma receptor Ia	Homo sapiens	34-43
18336259-4	2008	In agreement with this observation, exogenous Nef protein colocalized with GM1 ganglioside, a major component of lipid rafts, in U937 cells as detected by confocal microscopy.	G(M1) Ganglioside	75-90	S100 calcium binding protein B	Homo sapiens	46-49
17983613-5	2008	Cross-linking of GM1 by CTB or raft aggregation by methyl-beta-cyclodextrin further decreased the recovery of DiI-C(18:0).	G(M1) Ganglioside	17-20	phosphate cytidylyltransferase 1B, choline	Homo sapiens	24-27
18429602-0	2008	Ganglioside GM1-binding sites in interleukin-4: a photoaffinity labeling study.	G(M1) Ganglioside	12-15	interleukin 4	Homo sapiens	33-46
17697937-0	2007	GM1 ganglioside induces vasodilation and increases catalase content in the brain.	G(M1) Ganglioside	0-15	catalase	Rattus norvegicus	51-59
17932227-5	2007	PepT1 colocalized with lipid raft markers GM1 and N-aminopeptidase in intestinal BBMs and Caco2-BBE cell membranes.	G(M1) Ganglioside	42-45	solute carrier family 15 member 1	Homo sapiens	0-5
18173730-1	2008	We previously observed that gangliosides GM2, GM1, and GM3 inhibit Ca2+-uptake via the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in neurons and in brain microsomes.	G(M1) Ganglioside	46-49	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	87-126
18173730-1	2008	We previously observed that gangliosides GM2, GM1, and GM3 inhibit Ca2+-uptake via the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in neurons and in brain microsomes.	G(M1) Ganglioside	46-49	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	128-133
17608628-5	2007	Molecular analysis demonstrated that the PR#1-Fuc(Gal)-GM1 pathway was associated with Fyn and Yes of the Src family of kinases, although Src itself was not involved.	G(M1) Ganglioside	55-58	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	87-90
17608628-5	2007	Molecular analysis demonstrated that the PR#1-Fuc(Gal)-GM1 pathway was associated with Fyn and Yes of the Src family of kinases, although Src itself was not involved.	G(M1) Ganglioside	55-58	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	106-109
17697937-2	2007	GM1 increases catalase activity in cerebral cortices in vivo, but the mechanisms underlying this effect of GM1 are not known.	G(M1) Ganglioside	0-3	catalase	Rattus norvegicus	14-22
17697937-3	2007	In the current study we investigated the effect of GM1 (50 mg/kg, ip) on the content of hemoglobin and catalase activity of hippocampus, cortex, and striatum of rats.	G(M1) Ganglioside	51-54	catalase	Rattus norvegicus	103-111
17697937-4	2007	GM1 administration increased catalase activity and hemoglobin content in brain samples after 30 min, but had no effect on blood catalase activity.	G(M1) Ganglioside	0-3	catalase	Rattus norvegicus	29-37
17697937-5	2007	GM1-induced increase in catalase activity was abolished by brain perfusion with heparinized saline.	G(M1) Ganglioside	0-3	catalase	Rattus norvegicus	24-32
17321494-7	2007	Furthermore, it is likely that risk factors for AD, including aging and the expression of apolipoprotein E4, alter GM1 distribution on the neuronal surface, leading to GAbeta generation.	G(M1) Ganglioside	115-118	apolipoprotein E	Homo sapiens	90-107
17321494-2	2007	A unique Abeta species was identified previously in an AD brain, which is characterized by its binding to the GM1 ganglioside (GM1).	G(M1) Ganglioside	110-125	amyloid beta precursor protein	Homo sapiens	9-14
17582434-3	2007	This study demonstrates that monosialoganglioside GM1 (GM1) released from damaged neurons catalyzes the formation of Abeta fibrils, the toxicity and the cell affinity of which are much stronger than those of Abeta fibrils formed in phosphate-buffered saline.	G(M1) Ganglioside	50-53	amyloid beta precursor protein	Rattus norvegicus	117-122
17582434-4	2007	Abeta-(1-40) was incubated with equimolar GM1 at 37 degrees C. After a lag period of 6-12 h, amyloid fibrils were formed, as confirmed by circular dichroism, thioflavin-T fluorescence, size-exclusion chromatography, and transmission electron microscopy.	G(M1) Ganglioside	42-45	amyloid beta precursor protein	Rattus norvegicus	0-5
17321494-7	2007	Furthermore, it is likely that risk factors for AD, including aging and the expression of apolipoprotein E4, alter GM1 distribution on the neuronal surface, leading to GAbeta generation.	G(M1) Ganglioside	115-118	alpha glucosidase	Homo sapiens	168-174
17321494-2	2007	A unique Abeta species was identified previously in an AD brain, which is characterized by its binding to the GM1 ganglioside (GM1).	G(M1) Ganglioside	110-113	amyloid beta precursor protein	Homo sapiens	9-14
17321494-3	2007	On the basis of the molecular characteristics of this GM1-bound Abeta (GAbeta), it was hypothesized that Abeta adopts an altered conformation through its binding to GM1, and GAbeta acts as a seed for Abeta fibrillogenesis in an AD brain.	G(M1) Ganglioside	54-57	alpha glucosidase	Homo sapiens	71-77
17482435-6	2007	Further studies indicated that fresh Abeta has high GM1 affinity.	G(M1) Ganglioside	52-55	amyloid beta precursor protein	Homo sapiens	37-42
17321494-3	2007	On the basis of the molecular characteristics of this GM1-bound Abeta (GAbeta), it was hypothesized that Abeta adopts an altered conformation through its binding to GM1, and GAbeta acts as a seed for Abeta fibrillogenesis in an AD brain.	G(M1) Ganglioside	54-57	amyloid beta precursor protein	Homo sapiens	64-69
17321494-3	2007	On the basis of the molecular characteristics of this GM1-bound Abeta (GAbeta), it was hypothesized that Abeta adopts an altered conformation through its binding to GM1, and GAbeta acts as a seed for Abeta fibrillogenesis in an AD brain.	G(M1) Ganglioside	54-57	alpha glucosidase	Homo sapiens	174-180
17321494-3	2007	On the basis of the molecular characteristics of this GM1-bound Abeta (GAbeta), it was hypothesized that Abeta adopts an altered conformation through its binding to GM1, and GAbeta acts as a seed for Abeta fibrillogenesis in an AD brain.	G(M1) Ganglioside	54-57	amyloid beta precursor protein	Homo sapiens	72-77
17401655-5	2007	In the presence of the inhibitor of tyrosine kinase of Trk receptors (K-252a) the protective and metabolic effects of GM1 on PC12 cells in conditions of oxidative stress caused by hydrogen peroxide are not observed or are markedly diminished.	G(M1) Ganglioside	118-121	trunk	Drosophila melanogaster	55-58
17661814-7	2007	He was a heterozygous compound with p.Arg595Trp in trans with one of the disease-causing mutations identified in his daughter; in leukocytes and plasma he showed lower beta-galactosidase activity than that observed in GM1 gangliosidosis carriers.	G(M1) Ganglioside	218-221	galactosidase beta 1	Homo sapiens	168-186
17408589-1	2007	The structure and dynamics of a single GM1 (Gal5-beta1,3-GalNAc4-beta1,4-(NeuAc3-alpha2,3)-Gal2-beta1,4-Glc1-beta1,1-Cer) embedded in a DPPC bilayer have been studied by MD simulations.	G(M1) Ganglioside	39-42	galectin 2	Homo sapiens	91-95
17412816-4	2007	In support of this hypothesis we have shown previously that TSHRs reside in GM1 ganglioside-enriched lipid rafts in the plasma membrane of TSHR-expressing cells.	G(M1) Ganglioside	76-91	thyroid stimulating hormone receptor	Rattus norvegicus	60-64
17325693-2	2007	Binding of cholera toxin B subunit (CTB) to ganglioside GM1 is a marker to identify lipid rafts.	G(M1) Ganglioside	44-59	phosphate cytidylyltransferase 1B, choline	Homo sapiens	11-34
17325693-2	2007	Binding of cholera toxin B subunit (CTB) to ganglioside GM1 is a marker to identify lipid rafts.	G(M1) Ganglioside	44-59	phosphate cytidylyltransferase 1B, choline	Homo sapiens	36-39
17325693-7	2007	However, our data show that the specificity of CTB for GM1 ganglioside is limited, because the binding capacity is partly resistant to inhibition of ganglioside synthesis and sensitive to trypsin digestion.	G(M1) Ganglioside	55-70	phosphate cytidylyltransferase 1B, choline	Homo sapiens	47-50
17325693-8	2007	Our results indicate that the binding of FITC-labeled CTB can be divided into at least three different categories: a specific binding of CTB to ganglioside GM1, a nonspecific binding of CTB probably to glycosylated surface proteins and a nonspecific binding of FITC to the cell surface.	G(M1) Ganglioside	156-159	phosphate cytidylyltransferase 1B, choline	Homo sapiens	54-57
17325693-8	2007	Our results indicate that the binding of FITC-labeled CTB can be divided into at least three different categories: a specific binding of CTB to ganglioside GM1, a nonspecific binding of CTB probably to glycosylated surface proteins and a nonspecific binding of FITC to the cell surface.	G(M1) Ganglioside	156-159	phosphate cytidylyltransferase 1B, choline	Homo sapiens	137-140
17325693-8	2007	Our results indicate that the binding of FITC-labeled CTB can be divided into at least three different categories: a specific binding of CTB to ganglioside GM1, a nonspecific binding of CTB probably to glycosylated surface proteins and a nonspecific binding of FITC to the cell surface.	G(M1) Ganglioside	156-159	phosphate cytidylyltransferase 1B, choline	Homo sapiens	137-140
17488728-5	2007	In addition, a significant accumulation of the major ganglioside GM1 and reduced SM was detected in the myelin fraction of ABCA2-null brain.	G(M1) Ganglioside	65-68	ATP-binding cassette, sub-family A (ABC1), member 2	Mus musculus	123-128
17429973-1	2007	The present studies explore multivalent ligand-receptor interactions between pentameric cholera toxin B subunits (CTB) and the corresponding membrane ligand, ganglioside GM1.	G(M1) Ganglioside	170-173	phosphate cytidylyltransferase 1B, choline	Homo sapiens	114-117
17372146-5	2007	Sucrose density gradient centrifugation analysis revealed that PSGL-1 was enriched in a low-density fraction together with the GM1 ganglioside after solubilization of the cell membranes with a nonionic detergent, Brij 58.	G(M1) Ganglioside	127-142	selectin P ligand	Homo sapiens	63-69
17372146-7	2007	Furthermore, immunofluorescence microscopic observation demonstrated that the localization of PSGL-1 differed from that of GM1 ganglioside, suggesting that PSGL-1 is associated with a microdomain distinct from that containing the GM1 ganglioside.	G(M1) Ganglioside	123-138	selectin P ligand	Homo sapiens	156-162
18019391-0	2007	GM1 and NGF modulate Ca2+ homeostasis and GAP43 mRNA expression in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate.	G(M1) Ganglioside	0-3	growth associated protein 43	Rattus norvegicus	42-47
18019391-6	2007	The expression of GAP43 mRNA in Glu plus GM1 and NGF incubated neurons was the highest as compared with that in other groups.	G(M1) Ganglioside	41-44	growth associated protein 43	Rattus norvegicus	18-23
17429973-5	2007	Studies of the effect of ligand density on multivalent CTB-GM1 interactions revealed that binding weakened with increasing GM1 density from 0.02 mol % to 10.0 mol %.	G(M1) Ganglioside	59-62	phosphate cytidylyltransferase 1B, choline	Homo sapiens	55-58
17429973-5	2007	Studies of the effect of ligand density on multivalent CTB-GM1 interactions revealed that binding weakened with increasing GM1 density from 0.02 mol % to 10.0 mol %.	G(M1) Ganglioside	123-126	phosphate cytidylyltransferase 1B, choline	Homo sapiens	55-58
17429973-6	2007	Such a result could be explained by the clustering of GM1 on the supported phospholipid membranes, which in turn inhibited the binding of CTB.	G(M1) Ganglioside	54-57	phosphate cytidylyltransferase 1B, choline	Homo sapiens	138-141
17355906-2	2007	The NGF-TrkA signaling is enhanced by exogenous GM1 ganglioside and this phenomenon is regarded as one of the functional aspects of GM1.	G(M1) Ganglioside	48-63	neurotrophic receptor tyrosine kinase 1	Homo sapiens	8-12
17355906-2	2007	The NGF-TrkA signaling is enhanced by exogenous GM1 ganglioside and this phenomenon is regarded as one of the functional aspects of GM1.	G(M1) Ganglioside	48-51	neurotrophic receptor tyrosine kinase 1	Homo sapiens	8-12
17355906-3	2007	The IgGs purified from patients" sera inhibited the NGF-TrkA signaling in GM1 pre-incubated PC12 cells.	G(M1) Ganglioside	74-77	neurotrophic receptor tyrosine kinase 1	Homo sapiens	56-60
17355906-7	2007	These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling.	G(M1) Ganglioside	38-41	neurotrophic receptor tyrosine kinase 1	Homo sapiens	226-230
17355906-7	2007	These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling.	G(M1) Ganglioside	95-98	neurotrophic receptor tyrosine kinase 1	Homo sapiens	226-230
17355906-7	2007	These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling.	G(M1) Ganglioside	95-98	neurotrophic receptor tyrosine kinase 1	Homo sapiens	226-230
17442943-0	2007	Inhibitory receptor signals suppress ligation-induced recruitment of NKG2D to GM1-rich membrane domains at the human NK cell immune synapse.	G(M1) Ganglioside	78-81	killer cell lectin like receptor K1	Homo sapiens	69-74
17306220-0	2007	GM1-ganglioside-induced Abeta assembly on synaptic membranes of cultured neurons.	G(M1) Ganglioside	0-15	amyloid beta precursor protein	Rattus norvegicus	24-29
17306220-2	2007	GM1 ganglioside was detected only on the surface of native and nerve-growth-factor (NGF)-treated PC12 cells.	G(M1) Ganglioside	0-15	nerve growth factor	Rattus norvegicus	63-82
17306220-2	2007	GM1 ganglioside was detected only on the surface of native and nerve-growth-factor (NGF)-treated PC12 cells.	G(M1) Ganglioside	0-15	nerve growth factor	Rattus norvegicus	84-87
17306220-3	2007	We investigated whether GM1 ganglioside on the surface of these cells is sufficiently potent to induce the assembly of an exogenous soluble amyloid beta-protein (Abeta).	G(M1) Ganglioside	24-39	amyloid beta precursor protein	Rattus norvegicus	162-167
17306220-6	2007	Abeta assembly in the culture was completely suppressed by the coincubation of Abeta with the subunit B of cholera toxin, a natural ligand for GM1 ganglioside, or 4396C, a monoclonal antibody specific to GM1-ganglioside-bound Abeta (GAbeta).	G(M1) Ganglioside	143-158	amyloid beta precursor protein	Rattus norvegicus	0-5
17306220-6	2007	Abeta assembly in the culture was completely suppressed by the coincubation of Abeta with the subunit B of cholera toxin, a natural ligand for GM1 ganglioside, or 4396C, a monoclonal antibody specific to GM1-ganglioside-bound Abeta (GAbeta).	G(M1) Ganglioside	143-158	amyloid beta precursor protein	Rattus norvegicus	79-84
17306220-6	2007	Abeta assembly in the culture was completely suppressed by the coincubation of Abeta with the subunit B of cholera toxin, a natural ligand for GM1 ganglioside, or 4396C, a monoclonal antibody specific to GM1-ganglioside-bound Abeta (GAbeta).	G(M1) Ganglioside	143-158	amyloid beta precursor protein	Rattus norvegicus	79-84
17306220-6	2007	Abeta assembly in the culture was completely suppressed by the coincubation of Abeta with the subunit B of cholera toxin, a natural ligand for GM1 ganglioside, or 4396C, a monoclonal antibody specific to GM1-ganglioside-bound Abeta (GAbeta).	G(M1) Ganglioside	204-219	amyloid beta precursor protein	Rattus norvegicus	0-5
17306220-6	2007	Abeta assembly in the culture was completely suppressed by the coincubation of Abeta with the subunit B of cholera toxin, a natural ligand for GM1 ganglioside, or 4396C, a monoclonal antibody specific to GM1-ganglioside-bound Abeta (GAbeta).	G(M1) Ganglioside	204-219	amyloid beta precursor protein	Rattus norvegicus	79-84
17306220-6	2007	Abeta assembly in the culture was completely suppressed by the coincubation of Abeta with the subunit B of cholera toxin, a natural ligand for GM1 ganglioside, or 4396C, a monoclonal antibody specific to GM1-ganglioside-bound Abeta (GAbeta).	G(M1) Ganglioside	204-219	amyloid beta precursor protein	Rattus norvegicus	79-84
17306220-8	2007	These results suggest that the cell-surface expression of GM1 ganglioside is strictly cell-type-specific, and that expression of GM1 ganglioside on synaptic membranes is unique in terms of its high potency to induce Abeta assembly through the generation of GAbeta, which is an endogenous seed for Abeta assembly in Alzheimer brain.	G(M1) Ganglioside	129-144	amyloid beta precursor protein	Rattus norvegicus	216-221
17306220-8	2007	These results suggest that the cell-surface expression of GM1 ganglioside is strictly cell-type-specific, and that expression of GM1 ganglioside on synaptic membranes is unique in terms of its high potency to induce Abeta assembly through the generation of GAbeta, which is an endogenous seed for Abeta assembly in Alzheimer brain.	G(M1) Ganglioside	129-144	amyloid beta precursor protein	Rattus norvegicus	258-263
17428477-8	2007	GM(1) was found to co-localize with prominin-1 on microvilli whereas GM(3) was segregated from there suggesting its localization in the planar region.	G(M1) Ganglioside	0-5	prominin 1	Homo sapiens	36-46
17442943-2	2007	In cytolytic conjugates between NK cells and target cells expressing its ligand MHC class I chain-related gene A, NKG2D accumulates at the immunological synapse with GM1-rich microdomains.	G(M1) Ganglioside	166-169	killer cell lectin like receptor C1	Homo sapiens	114-118
17442943-6	2007	Thus, we propose that one way in which inhibitory signaling can control NKG2D-mediated activation is by blocking its recruitment to GM1-rich membrane domains.	G(M1) Ganglioside	132-135	killer cell lectin like receptor K1	Homo sapiens	72-77
17320845-11	2007	CONCLUSION: As the effect of GM-1 is blocked both at the receptor and the G-protein (Gi) levels, we conclude that S1P generated by GM-1 treatment must be exported from the cell and acts in a paracrine or autocrine manner to couple with its cognate receptor.	G(M1) Ganglioside	29-33	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
17374046-9	2007	The results indicate that GM1 and LIGA20 pretreatments induced statistically significant reductions-approximately 50% of the ethanol-treated samples-in silver impregnation and activated caspase-3 immunostaining.	G(M1) Ganglioside	26-29	caspase 3	Mus musculus	186-195
17320845-2	2007	We tested the following hypotheses: 1] cardiac myocytes null for the SphK1 gene are more vulnerable to the stress of hypoxia+glucose deprivation; 2] the monoganglioside GM-1, which activates SphK via protein kinase C epsilon, is ineffective in SphK1-null myocytes; 3] S1P generated by SphK activation requires cellular export to be cardioprotective.	G(M1) Ganglioside	169-173	sphingosine kinase 1	Mus musculus	69-74
17123354-0	2007	p56lck, LFA-1 and PI3K but not SHP-2 interact with GM1- or GM3-enriched microdomains in a CD4-p56lck association-dependent manner.	G(M1) Ganglioside	51-54	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-6
17320845-2	2007	We tested the following hypotheses: 1] cardiac myocytes null for the SphK1 gene are more vulnerable to the stress of hypoxia+glucose deprivation; 2] the monoganglioside GM-1, which activates SphK via protein kinase C epsilon, is ineffective in SphK1-null myocytes; 3] S1P generated by SphK activation requires cellular export to be cardioprotective.	G(M1) Ganglioside	169-173	protein kinase C, epsilon	Mus musculus	200-224
17320845-2	2007	We tested the following hypotheses: 1] cardiac myocytes null for the SphK1 gene are more vulnerable to the stress of hypoxia+glucose deprivation; 2] the monoganglioside GM-1, which activates SphK via protein kinase C epsilon, is ineffective in SphK1-null myocytes; 3] S1P generated by SphK activation requires cellular export to be cardioprotective.	G(M1) Ganglioside	169-173	sphingosine kinase 1	Mus musculus	244-249
17320845-2	2007	We tested the following hypotheses: 1] cardiac myocytes null for the SphK1 gene are more vulnerable to the stress of hypoxia+glucose deprivation; 2] the monoganglioside GM-1, which activates SphK via protein kinase C epsilon, is ineffective in SphK1-null myocytes; 3] S1P generated by SphK activation requires cellular export to be cardioprotective.	G(M1) Ganglioside	169-173	sphingosine-1-phosphate receptor 1	Mus musculus	268-271
17320845-10	2007	In wildtype cells, enhanced survival produced by GM-1 was abrogated by pretreatment either with 300 nM of the S1P(1) receptor-selective antagonist VPC23019 or with 100 ng/ml of pertussis toxin for 16 h before exposure to hypoxia+glucose deprivation.	G(M1) Ganglioside	49-53	sphingosine-1-phosphate receptor 1	Mus musculus	110-113
17264085-9	2007	Consistent with this, there was a time-dependent increase in colocalization between IK1 and the lipid raft ganglioside GM1 on the plasma membrane, which subsequently decreased with volume recovery.	G(M1) Ganglioside	119-122	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	84-87
17250589-4	2007	This study provides evidence for the occurrence of two peripheral blood monocyte subpopulations on the basis of their differential expression of GM1, a sphingolipid found mostly in lipid rafts, a CD14(+) GM1(low) population and a CD14(+) GM1(high) population comprising about 97.5% and 2.5% of total CD14(+) cells, respectively.	G(M1) Ganglioside	145-148	CD14 molecule	Homo sapiens	196-200
17250589-4	2007	This study provides evidence for the occurrence of two peripheral blood monocyte subpopulations on the basis of their differential expression of GM1, a sphingolipid found mostly in lipid rafts, a CD14(+) GM1(low) population and a CD14(+) GM1(high) population comprising about 97.5% and 2.5% of total CD14(+) cells, respectively.	G(M1) Ganglioside	145-148	CD14 molecule	Homo sapiens	230-234
17250589-4	2007	This study provides evidence for the occurrence of two peripheral blood monocyte subpopulations on the basis of their differential expression of GM1, a sphingolipid found mostly in lipid rafts, a CD14(+) GM1(low) population and a CD14(+) GM1(high) population comprising about 97.5% and 2.5% of total CD14(+) cells, respectively.	G(M1) Ganglioside	145-148	CD14 molecule	Homo sapiens	230-234
17250589-5	2007	GM1 expression correlates with functional differences in terms of endocytic activity, susceptibility to mycobacterial infection, and response to lipopolysaccharide (LPS) (modulation of Toll-like receptor-4 expression).	G(M1) Ganglioside	0-3	toll like receptor 4	Homo sapiens	185-205
17250589-6	2007	CD14(+) GM1(low) cells proved to be less endocytic and more responsive to LPS, whereas CD14(+) GM1(high) cells are more endocytic and less responsive to LPS.	G(M1) Ganglioside	8-11	CD14 molecule	Homo sapiens	0-4
17250589-6	2007	CD14(+) GM1(low) cells proved to be less endocytic and more responsive to LPS, whereas CD14(+) GM1(high) cells are more endocytic and less responsive to LPS.	G(M1) Ganglioside	95-98	CD14 molecule	Homo sapiens	87-91
17250589-7	2007	In addition, during monocyte to macrophage differentiation in vitro, the percentage of CD14(+) GM1(high) cells increases from about 2.5% at day 1 to more than 50% at day 7 of culture.	G(M1) Ganglioside	95-98	CD14 molecule	Homo sapiens	87-91
17250589-9	2007	The expression of CD16 on GM1(high) favours the first possibility and, on the other hand that up-regulation of GM1 expression and probably lipid rafts function is involved in the monocyte to macrophage differentiation process.	G(M1) Ganglioside	26-29	Fc gamma receptor IIIa	Homo sapiens	18-22
17250589-9	2007	The expression of CD16 on GM1(high) favours the first possibility and, on the other hand that up-regulation of GM1 expression and probably lipid rafts function is involved in the monocyte to macrophage differentiation process.	G(M1) Ganglioside	111-114	Fc gamma receptor IIIa	Homo sapiens	18-22
17163424-5	2007	NK cells were critically required for IFNalpha-mediated rejection of hepatic metastasis, because their depletion by injecting anti-asialo GM1 antibody completely abolished the antimetastatic effect.	G(M1) Ganglioside	138-141	interferon alpha	Mus musculus	38-46
17123354-0	2007	p56lck, LFA-1 and PI3K but not SHP-2 interact with GM1- or GM3-enriched microdomains in a CD4-p56lck association-dependent manner.	G(M1) Ganglioside	51-54	integrin subunit alpha L	Homo sapiens	8-13
17123354-0	2007	p56lck, LFA-1 and PI3K but not SHP-2 interact with GM1- or GM3-enriched microdomains in a CD4-p56lck association-dependent manner.	G(M1) Ganglioside	51-54	CD4 molecule	Homo sapiens	90-93
17123354-0	2007	p56lck, LFA-1 and PI3K but not SHP-2 interact with GM1- or GM3-enriched microdomains in a CD4-p56lck association-dependent manner.	G(M1) Ganglioside	51-54	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-100
17489102-6	2007	Our data show that MRP1 was exclusively found in "light" fractions known as L0 phase membrane microdomains, together with 23% of gangliosides GM1 and 40% of caveolin-1.	G(M1) Ganglioside	142-145	ATP binding cassette subfamily C member 1	Homo sapiens	19-23
17256880-4	2007	Abeta exhibited direct and favorable interactions with GM1 as Abeta insertion monotonically increased with GM1 concentration, despite increases in monolayer rigidity at low GM1 levels.	G(M1) Ganglioside	55-58	beta amyloid protein precursor-like	Drosophila melanogaster	0-5
17453416-6	2007	Our confocal microscopy results suggested that EGFR co-localized with GM1-positive rafts.	G(M1) Ganglioside	70-73	epidermal growth factor receptor	Homo sapiens	47-51
17256880-4	2007	Abeta exhibited direct and favorable interactions with GM1 as Abeta insertion monotonically increased with GM1 concentration, despite increases in monolayer rigidity at low GM1 levels.	G(M1) Ganglioside	55-58	beta amyloid protein precursor-like	Drosophila melanogaster	62-67
17253773-6	2007	alpha-Synuclein binding to GM1-containing SUVs was accompanied by formation of oligomers of alpha-synuclein.	G(M1) Ganglioside	27-30	synuclein alpha	Homo sapiens	0-15
17253773-6	2007	alpha-Synuclein binding to GM1-containing SUVs was accompanied by formation of oligomers of alpha-synuclein.	G(M1) Ganglioside	27-30	synuclein alpha	Homo sapiens	92-107
17253773-0	2007	GM1 specifically interacts with alpha-synuclein and inhibits fibrillation.	G(M1) Ganglioside	0-3	synuclein alpha	Homo sapiens	32-47
17256880-4	2007	Abeta exhibited direct and favorable interactions with GM1 as Abeta insertion monotonically increased with GM1 concentration, despite increases in monolayer rigidity at low GM1 levels.	G(M1) Ganglioside	107-110	beta amyloid protein precursor-like	Drosophila melanogaster	0-5
17253773-3	2007	We examined the interactions between several brain sphingolipids and alpha-synuclein and found that alpha-synuclein specifically binds to ganglioside GM1-containing small unilamellar vesicles (SUVs).	G(M1) Ganglioside	150-153	synuclein alpha	Homo sapiens	69-84
17253773-7	2007	The familial mutant A53T alpha-synuclein interacted with GM1-containing SUVs in an analogous manner to wild type, whereas the A30P mutant showed minimal interaction.	G(M1) Ganglioside	57-60	synuclein alpha	Homo sapiens	25-40
17253773-8	2007	This is the first detailed report showing a direct association between GM1 and alpha-synuclein, which is attributed to specific interaction between helical alpha-synuclein and both the sialic acid and carbohydrate moieties of GM1.	G(M1) Ganglioside	71-74	synuclein alpha	Homo sapiens	79-94
17253773-3	2007	We examined the interactions between several brain sphingolipids and alpha-synuclein and found that alpha-synuclein specifically binds to ganglioside GM1-containing small unilamellar vesicles (SUVs).	G(M1) Ganglioside	150-153	synuclein alpha	Homo sapiens	100-115
17253773-8	2007	This is the first detailed report showing a direct association between GM1 and alpha-synuclein, which is attributed to specific interaction between helical alpha-synuclein and both the sialic acid and carbohydrate moieties of GM1.	G(M1) Ganglioside	71-74	synuclein alpha	Homo sapiens	156-171
17256880-4	2007	Abeta exhibited direct and favorable interactions with GM1 as Abeta insertion monotonically increased with GM1 concentration, despite increases in monolayer rigidity at low GM1 levels.	G(M1) Ganglioside	107-110	beta amyloid protein precursor-like	Drosophila melanogaster	62-67
17253773-8	2007	This is the first detailed report showing a direct association between GM1 and alpha-synuclein, which is attributed to specific interaction between helical alpha-synuclein and both the sialic acid and carbohydrate moieties of GM1.	G(M1) Ganglioside	226-229	synuclein alpha	Homo sapiens	79-94
17253773-4	2007	This results in the induction of substantial alpha-helical structure and inhibition or elimination of alpha-synuclein fibril formation, depending on the amount of GM1 present.	G(M1) Ganglioside	163-166	synuclein alpha	Homo sapiens	102-117
17256880-4	2007	Abeta exhibited direct and favorable interactions with GM1 as Abeta insertion monotonically increased with GM1 concentration, despite increases in monolayer rigidity at low GM1 levels.	G(M1) Ganglioside	107-110	beta amyloid protein precursor-like	Drosophila melanogaster	0-5
17253773-9	2007	The recruitment of alpha-synuclein by GM1 to caveolae and lipid raft regions in membranes could explain alpha-synuclein"s localization to presynaptic membranes and raises the possibility that perturbation of GM1/raft association could induce changes in alpha-synuclein that contribute to the pathogenesis of PD.	G(M1) Ganglioside	38-41	synuclein alpha	Homo sapiens	19-34
17253773-9	2007	The recruitment of alpha-synuclein by GM1 to caveolae and lipid raft regions in membranes could explain alpha-synuclein"s localization to presynaptic membranes and raises the possibility that perturbation of GM1/raft association could induce changes in alpha-synuclein that contribute to the pathogenesis of PD.	G(M1) Ganglioside	38-41	synuclein alpha	Homo sapiens	104-119
17253773-9	2007	The recruitment of alpha-synuclein by GM1 to caveolae and lipid raft regions in membranes could explain alpha-synuclein"s localization to presynaptic membranes and raises the possibility that perturbation of GM1/raft association could induce changes in alpha-synuclein that contribute to the pathogenesis of PD.	G(M1) Ganglioside	38-41	synuclein alpha	Homo sapiens	104-119
17256880-4	2007	Abeta exhibited direct and favorable interactions with GM1 as Abeta insertion monotonically increased with GM1 concentration, despite increases in monolayer rigidity at low GM1 levels.	G(M1) Ganglioside	107-110	beta amyloid protein precursor-like	Drosophila melanogaster	62-67
17253773-9	2007	The recruitment of alpha-synuclein by GM1 to caveolae and lipid raft regions in membranes could explain alpha-synuclein"s localization to presynaptic membranes and raises the possibility that perturbation of GM1/raft association could induce changes in alpha-synuclein that contribute to the pathogenesis of PD.	G(M1) Ganglioside	208-211	synuclein alpha	Homo sapiens	19-34
17256880-5	2007	At low GM1 concentrations, Abeta preferentially inserted into the disordered, liquid expanded phase.	G(M1) Ganglioside	7-10	beta amyloid protein precursor-like	Drosophila melanogaster	27-32
17256880-6	2007	At higher GM1 concentrations, Abeta inserted more uniformly into the monolayer, resulting in no detectable preferences for either the disordered or condensed phase.	G(M1) Ganglioside	10-13	beta amyloid protein precursor-like	Drosophila melanogaster	30-35
17256880-7	2007	Abeta insertion led to the disruption of membrane morphology, specifically to the expansion of the disordered phase at low GM1 concentrations and significant disruption of the condensed domains at higher GM1 concentrations.	G(M1) Ganglioside	123-126	beta amyloid protein precursor-like	Drosophila melanogaster	0-5
17256880-7	2007	Abeta insertion led to the disruption of membrane morphology, specifically to the expansion of the disordered phase at low GM1 concentrations and significant disruption of the condensed domains at higher GM1 concentrations.	G(M1) Ganglioside	204-207	beta amyloid protein precursor-like	Drosophila melanogaster	0-5
17256880-8	2007	During incubation with POPC vesicles containing physiological levels of GM1, the association of Abeta with vesicles seeded the formation of Abeta fibrils.	G(M1) Ganglioside	72-75	beta amyloid protein precursor-like	Drosophila melanogaster	96-101
17256880-8	2007	During incubation with POPC vesicles containing physiological levels of GM1, the association of Abeta with vesicles seeded the formation of Abeta fibrils.	G(M1) Ganglioside	72-75	beta amyloid protein precursor-like	Drosophila melanogaster	140-145
17256880-9	2007	In conclusion, favorable interactions between Abeta and GM1 in the cell membrane may provide a mechanism for Abeta fibrillogenesis in vivo, and Abeta-induced disruption of the cell membrane may provide a pathway by which Abeta exerts toxicity.	G(M1) Ganglioside	56-59	beta amyloid protein precursor-like	Drosophila melanogaster	109-114
17256880-9	2007	In conclusion, favorable interactions between Abeta and GM1 in the cell membrane may provide a mechanism for Abeta fibrillogenesis in vivo, and Abeta-induced disruption of the cell membrane may provide a pathway by which Abeta exerts toxicity.	G(M1) Ganglioside	56-59	beta amyloid protein precursor-like	Drosophila melanogaster	109-114
17471167-7	2007	Importantly, we found that in vivo anti-CD25 mAb treatment significantly decreased the contribution of asialo GM1 cells in the antitumor response.	G(M1) Ganglioside	110-113	interleukin 2 receptor, alpha chain	Mus musculus	40-44
17079651-4	2007	Furthermore, the plasma membrane expression of the lipid raft marker GM1, which increases upon stimulation of GM-CSF-primed cells with fMLP, was reduced significantly in MDS patients.	G(M1) Ganglioside	69-72	colony stimulating factor 2	Homo sapiens	110-116
17079651-4	2007	Furthermore, the plasma membrane expression of the lipid raft marker GM1, which increases upon stimulation of GM-CSF-primed cells with fMLP, was reduced significantly in MDS patients.	G(M1) Ganglioside	69-72	formyl peptide receptor 1	Homo sapiens	135-139
17079651-5	2007	By electron microscopy, we showed that the fMLP-induced increase in GM1 expression in GM-CSF-primed cells was a result of de novo synthesis, which was less efficient in MDS neutrophils.	G(M1) Ganglioside	68-71	formyl peptide receptor 1	Homo sapiens	43-47
17079651-5	2007	By electron microscopy, we showed that the fMLP-induced increase in GM1 expression in GM-CSF-primed cells was a result of de novo synthesis, which was less efficient in MDS neutrophils.	G(M1) Ganglioside	68-71	colony stimulating factor 2	Homo sapiens	86-92
17141202-4	2007	About 70% of opioid receptors in CPu and DOR in both cell lines were present in low-density (5-20% sucrose) membrane domains enriched in cholesterol and ganglioside M1 (GM1), characteristics of lipid rafts in plasma membranes.	G(M1) Ganglioside	169-172	opioid receptor, delta 1	Mus musculus	41-44
17221873-0	2007	GM1 gangliosidosis: molecular analysis of nine patients and development of an RT-PCR assay for GLB1 gene expression profiling.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	95-99
17221873-3	2007	The EBP, when affected, contributes to specific features of GM1 gangliosidosis patients, such as cardiomyopathy and connective-tissue abnormalities.	G(M1) Ganglioside	60-63	EBP cholestenol delta-isomerase	Homo sapiens	4-7
17221873-5	2007	We also report the characterisation of GLB1 gene mutations in nine GM1 gangliosidosis patients in order to correlate the genetic lesions with mRNA levels and phenotypes.	G(M1) Ganglioside	67-70	galactosidase beta 1	Homo sapiens	39-43
17194147-4	2007	These GM1-sensitized, sulforhodamine B (SRB) dye-entrapping liposomes were used as probes in the FILIA system.	G(M1) Ganglioside	6-9	chaperonin containing TCP1 subunit 4	Homo sapiens	40-43
17069749-6	2007	NDGA and RIF inhibited the binding of Abeta to GM1 liposomes by competitively binding to the membranes and/or direct interaction with Abeta in solution, thus at least partly preventing fibrils from forming.	G(M1) Ganglioside	47-50	amyloid beta precursor protein	Rattus norvegicus	38-43
17069749-6	2007	NDGA and RIF inhibited the binding of Abeta to GM1 liposomes by competitively binding to the membranes and/or direct interaction with Abeta in solution, thus at least partly preventing fibrils from forming.	G(M1) Ganglioside	47-50	amyloid beta precursor protein	Rattus norvegicus	134-139
17069749-7	2007	Coincubation of Abeta with NDGA, RIF, and QUE in the presence of GM1 liposomes resulted in elongate particles, whereas the presence of TA yielded protofibrillar structures.	G(M1) Ganglioside	65-68	amyloid beta precursor protein	Rattus norvegicus	16-21
17069749-10	2007	Furthermore, a comparison of the inhibitory effects of various compounds between aqueous-phase and GM1-mediated aggregation of Abeta suggested that the two aggregation processes are not identical.	G(M1) Ganglioside	99-102	amyloid beta precursor protein	Rattus norvegicus	127-132
17052929-1	2006	GM1 gangliosidosis is an autosomal recessive glycosphingolipid storage disease caused by defects in the enzyme beta-galactosidase.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	111-129
16971381-7	2007	The GM1 ganglioside specific cholera toxin subunit B applied to TrkA-PC12 cells has no inhibitory effect on NGF-induced sialidase activity.	G(M1) Ganglioside	4-19	neurotrophic receptor tyrosine kinase 1	Homo sapiens	64-68
17161396-0	2006	Chloroquine-induced endocytic pathway abnormalities: Cellular model of GM1 ganglioside-induced Abeta fibrillogenesis in Alzheimer"s disease.	G(M1) Ganglioside	71-74	beta amyloid protein precursor-like	Drosophila melanogaster	95-100
17161396-3	2006	Chloroquine treatment induced accumulation of GM1 ganglioside (GM1) in Rab5-positive enlarged early endosomes and on the cell surface.	G(M1) Ganglioside	46-61	Rab5	Drosophila melanogaster	71-75
17161396-3	2006	Chloroquine treatment induced accumulation of GM1 ganglioside (GM1) in Rab5-positive enlarged early endosomes and on the cell surface.	G(M1) Ganglioside	46-49	Rab5	Drosophila melanogaster	71-75
17161396-4	2006	Notably, an increase in GM1 level on the cell surface was sufficient to induce Abeta assembly.	G(M1) Ganglioside	24-27	beta amyloid protein precursor-like	Drosophila melanogaster	79-84
16941490-7	2006	Because it has been claimed that amyloid-beta protein (Abeta) interacts with GM1 in PC12 cells to provide "seeding" for amyloid to accumulate, we further evaluated this possibility and found that Abeta is mostly likely interacting with fucosyl-GM1 in this cell line.	G(M1) Ganglioside	77-80	beta amyloid protein precursor-like	Drosophila melanogaster	55-60
16941490-7	2006	Because it has been claimed that amyloid-beta protein (Abeta) interacts with GM1 in PC12 cells to provide "seeding" for amyloid to accumulate, we further evaluated this possibility and found that Abeta is mostly likely interacting with fucosyl-GM1 in this cell line.	G(M1) Ganglioside	77-80	beta amyloid protein precursor-like	Drosophila melanogaster	196-201
16949204-0	2006	GM1 up-regulates Ubiquilin 1 expression in human neuroblastoma cells and rat cortical neurons.	G(M1) Ganglioside	0-3	ubiquilin 1	Homo sapiens	17-28
16949204-1	2006	GM1 ganglioside was reported to mediate the amyloid beta-protein (Abeta) secretion and accumulation in the pathogenesis of Alzheimer"s disease (AD).	G(M1) Ganglioside	0-15	amyloid beta precursor protein	Homo sapiens	66-71
16949204-7	2006	Furthermore, using Western blots, we discovered that GM1 stimulated the expression of Ubiquilin 1 in human neuroblastoma cells and rat cortical neurons while other gangliosides Asialo-GM1 and GD1b did not.	G(M1) Ganglioside	53-56	ubiquilin 1	Homo sapiens	86-97
16949204-8	2006	Ubiquilin 1 is one of the candidate genes of AD, which have been shown to modulate the gamma-secretase components in the proteolytic processing of APP, and is therefore a putative candidate for further investigation of GM1 mechanisms in the etiology and pathology of AD.	G(M1) Ganglioside	219-222	ubiquilin 1	Homo sapiens	0-11
17595532-6	2007	Furthermore, our studies indicate that the activation of the acid sphingomyelinase (ASM) is intrigued in the formation of ceramide- or GM1- enriched membrane platforms.	G(M1) Ganglioside	135-138	sphingomyelin phosphodiesterase 1	Homo sapiens	84-87
17156858-5	2007	Finally, GM1-specific IgA activated leukocytes through the IgA receptor, FcalphaRI (CD89).	G(M1) Ganglioside	9-12	Fc alpha receptor	Homo sapiens	84-88
16962073-4	2006	We first demonstrated that a co-treatment with GM1 (80 microM) reduced B[a]P (50 nM)-induced apoptosis as evidenced by a decrease of both cell population exhibiting nuclear fragmentation and caspase 3 cleavage and activity.	G(M1) Ganglioside	47-50	caspase 3	Rattus norvegicus	191-200
16962990-13	2006	Taken together, our results suggested that gangliosides GD1b, GM1, GM2 (lower concentrations) and GM3 stimulated the PMCA by the interaction with calmodulin-binding domain, while the interaction of GM2 with the "receptor" of the calmodulin-binding domain of the enzyme led to the inhibition of the enzyme.	G(M1) Ganglioside	62-65	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	117-121
16962990-13	2006	Taken together, our results suggested that gangliosides GD1b, GM1, GM2 (lower concentrations) and GM3 stimulated the PMCA by the interaction with calmodulin-binding domain, while the interaction of GM2 with the "receptor" of the calmodulin-binding domain of the enzyme led to the inhibition of the enzyme.	G(M1) Ganglioside	62-65	calmodulin 1	Homo sapiens	146-156
16962990-13	2006	Taken together, our results suggested that gangliosides GD1b, GM1, GM2 (lower concentrations) and GM3 stimulated the PMCA by the interaction with calmodulin-binding domain, while the interaction of GM2 with the "receptor" of the calmodulin-binding domain of the enzyme led to the inhibition of the enzyme.	G(M1) Ganglioside	62-65	calmodulin 1	Homo sapiens	229-239
16827894-5	2006	All IAM-associated CD55 was localised within GM1-containing lipid rafts.	G(M1) Ganglioside	45-48	CD55 molecule (Cromer blood group)	Homo sapiens	19-23
16911584-3	2006	Ganglioside distribution was altered in CT-2A tumor cells using an antisense construct to beta-1,4-N-acetylgalactosaminyltransferase (GalNAc-T), a key enzyme that uses the simple ganglioside GM3 as a substrate for the synthesis of the more complex gangliosides, GM2, GM1 and GD1a.	G(M1) Ganglioside	267-270	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	134-142
16847070-6	2006	Further, fluorescent resonance energy transfer between TLR4 and the raft marker GM1 as well as biochemical analysis of the raft components demonstrated that oxidative stress redistributes TLR4 to lipid rafts in the plasma membrane.	G(M1) Ganglioside	80-83	toll like receptor 4	Homo sapiens	188-192
16636068-8	2006	Low GM1-expressing cell lines showed increased proliferation and invasion, enrichment in the GEM/rafts, and increased secretion of MMP-9.	G(M1) Ganglioside	4-7	matrix metallopeptidase 9	Mus musculus	131-136
16636068-9	2006	Among adhesion molecules, only integrin beta1 was detected in GEM/rafts with stronger intensity in high metastatic lines and low GM1-expressing cells.	G(M1) Ganglioside	129-132	integrin beta 1 (fibronectin receptor beta)	Mus musculus	31-45
16497300-5	2006	Galectin-1 is a member of an adhesion/growth-regulatory family known to interact for example with ganglioside GM(1) and also the hydrophobic tail of oncogenic H-Ras.	G(M1) Ganglioside	110-115	galectin 1	Homo sapiens	0-10
16639029-6	2006	RESULTS: Differential punctate staining of membrane rafts was demonstrated in normal and FasL-induced apoptotic human ARPE-19 cells in culture by confocal microscopy, using cholera toxin B and GM1 labeling of extruded vesicles.	G(M1) Ganglioside	193-196	Fas ligand	Homo sapiens	89-93
16515539-7	2006	Moreover, surface plasmon resonance analyses revealed that L-PGDS binds GM1 and GM2 gangliosides, accumulated in neurons in the course of LSD, with high affinities (KD = 65 and 210 nm, respectively).	G(M1) Ganglioside	72-75	prostaglandin D2 synthase (brain)	Mus musculus	59-65
16565709-6	2006	In addition, syntaxin 6 inhibition decreased the delivery of GM1 ganglioside (GM1) and glycosylphosphatidylinositol (GPI)-GFP (but not vesicular stomatitis virus-glycoprotein G; VSV-G) protein from the Golgi complex to the plasma membrane.	G(M1) Ganglioside	61-76	Syntaxin 6	Drosophila melanogaster	13-23
16565709-6	2006	In addition, syntaxin 6 inhibition decreased the delivery of GM1 ganglioside (GM1) and glycosylphosphatidylinositol (GPI)-GFP (but not vesicular stomatitis virus-glycoprotein G; VSV-G) protein from the Golgi complex to the plasma membrane.	G(M1) Ganglioside	61-64	Syntaxin 6	Drosophila melanogaster	13-23
16565709-7	2006	Addition of GM1 to syntaxin 6-inhibited cells resulted in the reappearance of caveolin-1 and caveolae at the plasma membrane, and restored caveolar uptake.	G(M1) Ganglioside	12-15	Syntaxin 6	Drosophila melanogaster	19-29
16596236-5	2006	Interestingly, both anti-asialo GM1 and anti-CD11b treatment strongly decreased MHC expression in B16/IL-2.	G(M1) Ganglioside	32-35	interleukin 2	Mus musculus	102-106
16753870-2	2006	Rituximab, a chimeric monoclonal antibody against the CD20 molecule, has been used with success in patients with neuropathy and monoclonal IgM with anti-MAG or anti-GM1 ganglioside activity.	G(M1) Ganglioside	165-180	keratin 20	Homo sapiens	54-58
16270308-3	2006	We have demonstrated that the C. jejuni HB9313 (HS:19) parental strain expresses a LOS structure containing GM1-like epitopes, and the C. jejuni knockout mutant of the galE gene expresses a truncated LOS structure without GM1-like epitopes.	G(M1) Ganglioside	108-111	UDP-glucose 4-epimerase	Cavia porcellus	168-172
16538029-5	2006	Following treatment with RANKL, ganglioside GM3 and GM1 were increased in the treated bone marrow cells, whereas other types were not detected using thin layer chromatography analysis.	G(M1) Ganglioside	52-55	TNF superfamily member 11	Homo sapiens	25-30
16341049-3	2006	Using minimal detergent solubilization of CLL membranes, we found that CD52 colocalizes with ganglioside GM-1, a marker of membrane rafts.	G(M1) Ganglioside	93-109	CD52 molecule	Homo sapiens	71-75
16270308-3	2006	We have demonstrated that the C. jejuni HB9313 (HS:19) parental strain expresses a LOS structure containing GM1-like epitopes, and the C. jejuni knockout mutant of the galE gene expresses a truncated LOS structure without GM1-like epitopes.	G(M1) Ganglioside	222-225	UDP-glucose 4-epimerase	Cavia porcellus	168-172
16393970-0	2006	The decreased susceptibility of Bcr/Abl targets to NK cell-mediated lysis in response to imatinib mesylate involves modulation of NKG2D ligands, GM1 expression, and synapse formation.	G(M1) Ganglioside	145-148	BCR activator of RhoGEF and GTPase	Homo sapiens	32-35
16444586-5	2006	Among the acidic sphingolipids, SCP-2 resulted in a 5.2-fold decrease in the endogenous plasma membrane level of ganglioside GM1 (p < 0.03).	G(M1) Ganglioside	125-128	sterol carrier protein 2, liver	Mus musculus	32-37
16393952-3	2006	We report that in human T cells, CD28, CD59, and CD55 are all localized into lipid rafts and that CD28 is concentrated into microdomains enriched in ganglioside GM1, whereas CD59 and CD55 are not.	G(M1) Ganglioside	161-164	CD28 molecule	Homo sapiens	98-102
16393970-4	2006	The main effect of IM involves an induction of surface GM1 ganglioside on Bcr/Abl transfectants that prevents the redistribution of MHC-related Ag molecules in lipid rafts upon interaction with NK cells.	G(M1) Ganglioside	55-70	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	74-81
16393970-8	2006	Taken together, our results show that the high expression of Bcr/Abl in leukemic cells controls the expression of NKG2D receptor ligands and membrane GM1 via a tyrosine kinase-dependent mechanism and that the modulation of these molecules by IM interferes with NK cell recognition and cytolysis of the transfectants.	G(M1) Ganglioside	150-153	BCR activator of RhoGEF and GTPase	Homo sapiens	61-64
15980365-1	2005	Adherence of Candida albicans to buccal epithelial cells via its fimbrial subunit requires the minimal disaccharide sequence beta-GalNAc(1-4)-beta-galactosidase in host cell receptors asialo-GM1 or asialo-GM2.	G(M1) Ganglioside	191-194	galactosidase, beta 1	Rattus norvegicus	142-160
16266689-7	2005	Using a Brij 98 solubilization protocol and sucrose gradient partition we demonstrated that the CD52 glycoforms recognized by both antibodies are markers of typical raft microdomains in leukocytes, whereas in capacitated sperm the O-glycoform is included in GM3-rich microdomains different from the cholesterol and GM1-rich lipid rafts with which CAMPATH antigen is stably associated.	G(M1) Ganglioside	315-318	CD52 molecule	Homo sapiens	96-100
16079415-0	2005	Synthesis of novel NBD-GM1 and NBD-GM2 for the transfer activity of GM2-activator protein by a FRET-based assay system.	G(M1) Ganglioside	23-26	ganglioside GM2 activator	Homo sapiens	68-89
16107506-7	2005	Lipid raft markers flotillin-2 and GM1 colocalized with AQP5 and moved with AQP5 in response to cevimeline.	G(M1) Ganglioside	35-38	aquaporin 5	Rattus norvegicus	56-60
16107506-7	2005	Lipid raft markers flotillin-2 and GM1 colocalized with AQP5 and moved with AQP5 in response to cevimeline.	G(M1) Ganglioside	35-38	aquaporin 5	Rattus norvegicus	76-80
16084500-1	2005	We investigated the ability of GM1 to induce phosphorylation/activation of the extracellular-regulated protein kinases (ERKs) in the striatum, hippocampus and frontal cortex of aged male Sprague-Dawley rats.	G(M1) Ganglioside	31-34	mitogen activated protein kinase 3	Rattus norvegicus	120-124
16084500-3	2005	In situ, GM1 induced a rapid and transient activation of ERK1 and ERK 2 in both young and aged rats, and a similar effect was observed after stimulation with the neurotrophins NGF and BDNF.	G(M1) Ganglioside	9-12	mitogen activated protein kinase 3	Rattus norvegicus	57-61
16084500-3	2005	In situ, GM1 induced a rapid and transient activation of ERK1 and ERK 2 in both young and aged rats, and a similar effect was observed after stimulation with the neurotrophins NGF and BDNF.	G(M1) Ganglioside	9-12	mitogen activated protein kinase 1	Rattus norvegicus	66-71
16084500-3	2005	In situ, GM1 induced a rapid and transient activation of ERK1 and ERK 2 in both young and aged rats, and a similar effect was observed after stimulation with the neurotrophins NGF and BDNF.	G(M1) Ganglioside	9-12	brain-derived neurotrophic factor	Rattus norvegicus	184-188
16084500-5	2005	Acute icv administration of GM1 resulted in short-lasting phosphorylation of ERKs in both aged groups, while chronic administration of GM1 induced a protracted phosphorylation of ERKs.	G(M1) Ganglioside	28-31	mitogen activated protein kinase 3	Rattus norvegicus	77-81
16084500-5	2005	Acute icv administration of GM1 resulted in short-lasting phosphorylation of ERKs in both aged groups, while chronic administration of GM1 induced a protracted phosphorylation of ERKs.	G(M1) Ganglioside	135-138	mitogen activated protein kinase 3	Rattus norvegicus	179-183
16084500-7	2005	In agreement with reports that GM1 phosphorylates TrkA in vitro or in situ, treatment with GM1 increased the phosphorylation of TrkA in hippocampus of both young and aged animals.	G(M1) Ganglioside	31-34	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	50-54
16084500-7	2005	In agreement with reports that GM1 phosphorylates TrkA in vitro or in situ, treatment with GM1 increased the phosphorylation of TrkA in hippocampus of both young and aged animals.	G(M1) Ganglioside	91-94	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	50-54
16084500-7	2005	In agreement with reports that GM1 phosphorylates TrkA in vitro or in situ, treatment with GM1 increased the phosphorylation of TrkA in hippocampus of both young and aged animals.	G(M1) Ganglioside	91-94	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	128-132
16084500-8	2005	These observations indicate that the aged brain maintains the ability to respond to neurotrophic stimuli and put forward the proposition that the ERK cascade is associated with the action(s) of GM1 ganglioside in vivo.	G(M1) Ganglioside	194-209	Eph receptor B1	Rattus norvegicus	146-149
16278452-6	2005	Importantly, we show that yeast Npc2p can efficiently revert the unesterified cholesterol and GM1 accumulation seen in hNPC2-/- patient fibroblasts demonstrating that it is a functional homologue of human NPC2.	G(M1) Ganglioside	94-97	sterol transporter	Saccharomyces cerevisiae S288C	32-37
16278452-6	2005	Importantly, we show that yeast Npc2p can efficiently revert the unesterified cholesterol and GM1 accumulation seen in hNPC2-/- patient fibroblasts demonstrating that it is a functional homologue of human NPC2.	G(M1) Ganglioside	94-97	NPC intracellular cholesterol transporter 2	Homo sapiens	119-124
16278452-6	2005	Importantly, we show that yeast Npc2p can efficiently revert the unesterified cholesterol and GM1 accumulation seen in hNPC2-/- patient fibroblasts demonstrating that it is a functional homologue of human NPC2.	G(M1) Ganglioside	94-97	NPC intracellular cholesterol transporter 2	Homo sapiens	120-124
16175551-7	2005	Fluorescence-activated cell sorting (FACS) analysis and characterization of E14 GM1-positive cells showed that they contain progenitor cells that proliferate in response to epidermal growth factor (EGF) and/or basic fibroblast growth factor (bFGF) stimulation.	G(M1) Ganglioside	80-83	epidermal growth factor	Mus musculus	173-196
16175551-7	2005	Fluorescence-activated cell sorting (FACS) analysis and characterization of E14 GM1-positive cells showed that they contain progenitor cells that proliferate in response to epidermal growth factor (EGF) and/or basic fibroblast growth factor (bFGF) stimulation.	G(M1) Ganglioside	80-83	epidermal growth factor	Mus musculus	198-201
16175551-7	2005	Fluorescence-activated cell sorting (FACS) analysis and characterization of E14 GM1-positive cells showed that they contain progenitor cells that proliferate in response to epidermal growth factor (EGF) and/or basic fibroblast growth factor (bFGF) stimulation.	G(M1) Ganglioside	80-83	fibroblast growth factor 2	Mus musculus	210-240
16175551-7	2005	Fluorescence-activated cell sorting (FACS) analysis and characterization of E14 GM1-positive cells showed that they contain progenitor cells that proliferate in response to epidermal growth factor (EGF) and/or basic fibroblast growth factor (bFGF) stimulation.	G(M1) Ganglioside	80-83	fibroblast growth factor 2	Mus musculus	242-246
16060692-3	2005	Using two-dimensional NMR techniques we have shown that at low concentration, GM1 micelle is able to induce an extended helical conformation to MLT.	G(M1) Ganglioside	78-81	MALT1 paracaspase	Homo sapiens	144-147
16060692-5	2005	While looking for the binding between MLT and GM1 using saturation transfer difference NMR spectroscopy, Val5, Leu9, Thr11, Ile17, Ser18, and Trp19 have been identified as the residues that are in close proximity to GM1 micelles.	G(M1) Ganglioside	46-49	MALT1 paracaspase	Homo sapiens	38-41
16060692-5	2005	While looking for the binding between MLT and GM1 using saturation transfer difference NMR spectroscopy, Val5, Leu9, Thr11, Ile17, Ser18, and Trp19 have been identified as the residues that are in close proximity to GM1 micelles.	G(M1) Ganglioside	46-49	CD7 molecule	Homo sapiens	111-115
16060692-5	2005	While looking for the binding between MLT and GM1 using saturation transfer difference NMR spectroscopy, Val5, Leu9, Thr11, Ile17, Ser18, and Trp19 have been identified as the residues that are in close proximity to GM1 micelles.	G(M1) Ganglioside	216-219	MALT1 paracaspase	Homo sapiens	38-41
16390012-10	2005	Both rLTB-rLipL41/1 and rCTB-rLipL41/1 could combine rabbit anti-rLipL41/1 serum as well as bovine GM1, respectively.	G(M1) Ganglioside	99-102	lymphotoxin beta	Rattus norvegicus	5-9
15668908-8	2005	In addition, anti-GSL antibodies, such as anti-GM1, may cause nerve dysfunction and injury by interfering with the ion channel function at the nodes of Ranvier, where carbohydrate epitopes of glycoconjugates are located.	G(M1) Ganglioside	47-50	cathepsin A	Homo sapiens	18-21
15960850-8	2005	In order to demonstrate the utility of our fluid membrane array technology to ligand/receptor studies, we investigated the multivalent binding of the cholera toxin B-subunit (CTB) to the membrane ganglioside GM1.	G(M1) Ganglioside	208-211	phosphate cytidylyltransferase 1B, choline	Homo sapiens	150-173
15960850-8	2005	In order to demonstrate the utility of our fluid membrane array technology to ligand/receptor studies, we investigated the multivalent binding of the cholera toxin B-subunit (CTB) to the membrane ganglioside GM1.	G(M1) Ganglioside	208-211	phosphate cytidylyltransferase 1B, choline	Homo sapiens	175-178
15967787-6	2005	T cells stimulated with anti-CD3 plus anti-CD28 antibodies showed an increase not only in surface monosialoganglioside GM1 expression but also in total amounts of raft-associated lipids such as sphingomyelin, cholesterol and glycosphingolipids.	G(M1) Ganglioside	119-122	CD28 molecule	Homo sapiens	43-47
15831905-6	2005	The cellular source for IFN-gamma on monoassociation of SCID mice with Schaedler"s E coli was localised to a subset of intraepithelial natural killer (IENK) cells that express asialo-GM1.	G(M1) Ganglioside	183-186	interferon gamma	Mus musculus	24-33
15911874-2	2005	The author previously identified a unique Abeta species in the AD brain, which is characterized by its binding to GM1 ganglioside (GM1).	G(M1) Ganglioside	114-129	amyloid beta precursor protein	Homo sapiens	42-47
15911874-2	2005	The author previously identified a unique Abeta species in the AD brain, which is characterized by its binding to GM1 ganglioside (GM1).	G(M1) Ganglioside	114-117	amyloid beta precursor protein	Homo sapiens	42-47
15911874-3	2005	On the basis of the molecular characteristics of GM1-bound Abeta (GAbeta), the author hypothesized that GM1 plays a critical role in the process.	G(M1) Ganglioside	49-52	alpha glucosidase	Homo sapiens	66-72
15911874-3	2005	On the basis of the molecular characteristics of GM1-bound Abeta (GAbeta), the author hypothesized that GM1 plays a critical role in the process.	G(M1) Ganglioside	104-107	alpha glucosidase	Homo sapiens	66-72
15911874-5	2005	Furthermore, the author provided a possibility that aging and the expression of apolipoprotein E4 facilitate Abeta assembly in the brain through an increase in the GM1 content in the neuronal membranes, which likely induces GAbeta generation.	G(M1) Ganglioside	164-167	apolipoprotein E	Homo sapiens	80-97
15911874-5	2005	Furthermore, the author provided a possibility that aging and the expression of apolipoprotein E4 facilitate Abeta assembly in the brain through an increase in the GM1 content in the neuronal membranes, which likely induces GAbeta generation.	G(M1) Ganglioside	164-167	amyloid beta precursor protein	Homo sapiens	109-114
15911874-5	2005	Furthermore, the author provided a possibility that aging and the expression of apolipoprotein E4 facilitate Abeta assembly in the brain through an increase in the GM1 content in the neuronal membranes, which likely induces GAbeta generation.	G(M1) Ganglioside	164-167	alpha glucosidase	Homo sapiens	224-230
15687347-1	2005	II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid beta-galactosidase (beta-gal), resulting in the accumulation of ganglioside GM1 and its asialo derivative GgOse4Cer (GA1) in the central nervous system, primarily in the brain.	G(M1) Ganglioside	20-23	galactosidase, beta 1	Mus musculus	113-131
15687347-1	2005	II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid beta-galactosidase (beta-gal), resulting in the accumulation of ganglioside GM1 and its asialo derivative GgOse4Cer (GA1) in the central nervous system, primarily in the brain.	G(M1) Ganglioside	20-23	galactosidase, beta 1	Mus musculus	113-121
15687347-1	2005	II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid beta-galactosidase (beta-gal), resulting in the accumulation of ganglioside GM1 and its asialo derivative GgOse4Cer (GA1) in the central nervous system, primarily in the brain.	G(M1) Ganglioside	189-192	galactosidase, beta 1	Mus musculus	113-131
15687347-1	2005	II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid beta-galactosidase (beta-gal), resulting in the accumulation of ganglioside GM1 and its asialo derivative GgOse4Cer (GA1) in the central nervous system, primarily in the brain.	G(M1) Ganglioside	189-192	galactosidase, beta 1	Mus musculus	113-121
15654743-8	2005	The ganglioside GM(1) is known as the receptor for CTB, but surprisingly the toxin also bound to sucrase-isomaltase and coclustered with this glycosidase in apical membrane pits.	G(M1) Ganglioside	16-21	sucrase-isomaltase	Sus scrofa	97-115
15924714-6	2005	However, the mean optical densities (ODs) of IgG antibody against GM1 at 14 and 28 day after immunization, in parental strain group, were 0.661 +/- 0.290 and 0.984 +/- 0.025, respectively, significantly higher than those of galE mutant group, which were 0.193 +/- 0.078 and 0.180 +/- 0.063 (P < 0.01).	G(M1) Ganglioside	66-69	UDP-glucose 4-epimerase	Cavia porcellus	224-228
15924714-12	2005	CONCLUSION: Compared with parental strain, galE mutant without ganglioside-like structure no longer could induce anti-GM1 antibodies, nor induce obvious immune damage of peripheral nerves in experimental guinea pigs.	G(M1) Ganglioside	118-121	UDP-glucose 4-epimerase	Cavia porcellus	43-47
15707979-2	2005	Liposomal studies proposed that Abeta specifically recognizes a cholesterol-dependent cluster of monosialoganglioside GM1 and a conformationally altered form of Abeta promotes the aggregation of the protein.	G(M1) Ganglioside	118-121	amyloid beta precursor protein	Rattus norvegicus	32-37
15754422-1	2005	OBJECTIVE: To determine the protective effect of monosialoganglionside (GM1) and evaluate the influence of GM1 on expression of N-methyl-D-aspartate receptor subunit 1 (NMDAR1) in Sprague-Dawley (SD) rats with focal cerebral ischemia-reperfusion (I/R).	G(M1) Ganglioside	107-110	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	128-167
15754422-1	2005	OBJECTIVE: To determine the protective effect of monosialoganglionside (GM1) and evaluate the influence of GM1 on expression of N-methyl-D-aspartate receptor subunit 1 (NMDAR1) in Sprague-Dawley (SD) rats with focal cerebral ischemia-reperfusion (I/R).	G(M1) Ganglioside	107-110	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	169-175
15754422-3	2005	Expression of NMDAR1 was detected by Western blot at various time after reperfusion (4 h, 6 h, 24 h, 48 h and 72 h) in ischemic hemispheres of the rats with or without GM1 administered.	G(M1) Ganglioside	168-171	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	14-20
15754422-6	2005	GM1 at 5 min after MCAo significantly suppressed the expression of NMDAR1 at 6 h after reperfusion (P<0.05 vs the control).	G(M1) Ganglioside	0-3	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	67-73
15754422-7	2005	At 72 h after reperfusion, the NMDAR1 expression level of rats treated with GM1 administered (at 5 min or 2 h after MCAo) was significantly higher than that of the control (P<0.05).	G(M1) Ganglioside	76-79	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	31-37
15754422-8	2005	CONCLUSION: GM1 can time-dependently reduce infarct volume in rats with focal cerebral I/R partly through stabilizing the expression of NMDAR1.	G(M1) Ganglioside	12-15	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	136-142
15542629-2	2004	Here we show that this is due to a transient association of Nef with a PAK2 activation complex within a detergent-insoluble membrane compartment containing the lipid raft marker GM1.	G(M1) Ganglioside	178-181	S100 calcium binding protein B	Homo sapiens	60-63
15328157-6	2004	CD157 localizes in GM1-enriched lipid rafts and, upon activation, it migrates to the uropod, a structure specialized in motility and adhesive functions.	G(M1) Ganglioside	19-22	bone marrow stromal cell antigen 1	Homo sapiens	0-5
15542629-2	2004	Here we show that this is due to a transient association of Nef with a PAK2 activation complex within a detergent-insoluble membrane compartment containing the lipid raft marker GM1.	G(M1) Ganglioside	178-181	p21 (RAC1) activated kinase 2	Homo sapiens	71-75
15662848-2	2004	The nuclear NCX1 exchanger, unlike that in the plasma membrane, was shown to be tightly associated with GM1 and potentiated by the latter.	G(M1) Ganglioside	104-107	solute carrier family 8 member A1	Homo sapiens	12-16
15662848-7	2004	Some alternatively spliced isoforms of NCX1 in the nuclear envelope of both cell types were tightly associated with ganglioside GM1.	G(M1) Ganglioside	128-131	solute carrier family 8 member A1	Homo sapiens	39-43
15662848-9	2004	The high affinity association between NCX1 and GM1, explored by reaction with base, acid, and proteases, was found to involve charge-charge interaction with a requirement for a positively charged moiety in NCX.	G(M1) Ganglioside	47-50	solute carrier family 8 member A1	Homo sapiens	38-42
15528994-4	2004	CD99 costimulation also led to elevated expression of CD25 and GM1 on the CD4+ T cell surface within 3 days.	G(M1) Ganglioside	63-66	CD99 molecule (Xg blood group)	Homo sapiens	0-4
15528994-4	2004	CD99 costimulation also led to elevated expression of CD25 and GM1 on the CD4+ T cell surface within 3 days.	G(M1) Ganglioside	63-66	CD4 molecule	Homo sapiens	74-77
15322154-5	2004	Binding of LFA-1 on CTL to targets initiates the formation of the immunological synapse, which is formed by LFA-1, CD3, and ganglioside GM1 distributed in the periphery of the cell contact site and cholesterol is more widely distributed.	G(M1) Ganglioside	136-139	integrin subunit alpha L	Homo sapiens	11-16
15302864-9	2004	Finally we showed that FPR stimulation in the absence of receptor phosphorylation resulted in translocation of FPR to GM1-rich clusters.	G(M1) Ganglioside	118-121	formyl peptide receptor 1	Homo sapiens	23-26
15302864-9	2004	Finally we showed that FPR stimulation in the absence of receptor phosphorylation resulted in translocation of FPR to GM1-rich clusters.	G(M1) Ganglioside	118-121	formyl peptide receptor 1	Homo sapiens	111-114
15388255-1	2004	CD99 is a 32kDa surface glycoprotein, which is involved in the migration of leukocytes and the transport of ganglioside GM1 and transmembrane proteins.	G(M1) Ganglioside	120-123	CD99 molecule (Xg blood group)	Homo sapiens	0-4
15325283-3	2004	Confocal microscopic colocalization experiments with GM(1) gangliosides and the GPI-anchored CD59 molecules showed enrichment of HLA I, HLA-DR, and ICAM-1 molecules in specific membrane domains (lipid rafts) excluding the transferrin receptor.	G(M1) Ganglioside	53-71	intercellular adhesion molecule 1	Homo sapiens	148-154
15383175-8	2004	Administration of anti-IL-5Ralpha and anti-asialo GM1 antibodies enhanced growth of MH134-pCXN2-eotaxin cells, suggesting involvement of eosinophils and NK cells in suppression of tumor cell growth.	G(M1) Ganglioside	50-53	chemokine (C-C motif) ligand 11	Mus musculus	96-103
15294298-4	2004	The binding of CTB-gp120 fusion protein pentamers to intestinal epithelial cell membrane glycolipid receptors was quantified by GM1-ganglioside enzyme-linked immunosorbent assay (GM1-ELISA).	G(M1) Ganglioside	128-131	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	19-24
15312164-7	2004	GM1 elicited a time-dependent increase in nerve growth factor protein and mRNA in NIH-3T3 cells expressing TrkA or TrkC receptor but not in wild-type cells.	G(M1) Ganglioside	0-3	nerve growth factor	Homo sapiens	42-61
15312164-7	2004	GM1 elicited a time-dependent increase in nerve growth factor protein and mRNA in NIH-3T3 cells expressing TrkA or TrkC receptor but not in wild-type cells.	G(M1) Ganglioside	0-3	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	107-111
15312164-7	2004	GM1 elicited a time-dependent increase in nerve growth factor protein and mRNA in NIH-3T3 cells expressing TrkA or TrkC receptor but not in wild-type cells.	G(M1) Ganglioside	0-3	neurotrophic tyrosine kinase, receptor, type 3	Mus musculus	115-119
15312164-9	2004	The ability of GM1 to increase nerve growth factor mRNA levels was blocked by TrkC-IgG but not by TrkB-IgG receptor body.	G(M1) Ganglioside	15-18	nerve growth factor	Homo sapiens	31-50
15312164-9	2004	The ability of GM1 to increase nerve growth factor mRNA levels was blocked by TrkC-IgG but not by TrkB-IgG receptor body.	G(M1) Ganglioside	15-18	neurotrophic receptor tyrosine kinase 3	Homo sapiens	78-82
15294298-4	2004	The binding of CTB-gp120 fusion protein pentamers to intestinal epithelial cell membrane glycolipid receptors was quantified by GM1-ganglioside enzyme-linked immunosorbent assay (GM1-ELISA).	G(M1) Ganglioside	179-182	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	19-24
15487588-1	2004	GM1 gangliosidosis is a progressive neurodegenerative disease caused by deficiencies in lysosomal acid beta-galactosidase (beta-gal) and involves accumulation and storage of ganglioside GM1 and its asialo form (GA1) in brain and visceral tissues.	G(M1) Ganglioside	0-3	galactosidase, beta 1	Mus musculus	103-121
15166239-3	2004	HS1-green fluorescent protein was localized in membrane patches enriched with GM1 gangliosides and BCR in the cells treated with anti-IgM antibody.	G(M1) Ganglioside	78-94	hematopoietic cell specific Lyn substrate 1	Mus musculus	0-3
15145933-0	2004	Overexpressed GM1 suppresses nerve growth factor (NGF) signals by modulating the intracellular localization of NGF receptors and membrane fluidity in PC12 cells.	G(M1) Ganglioside	14-17	nerve growth factor	Rattus norvegicus	29-48
15145933-0	2004	Overexpressed GM1 suppresses nerve growth factor (NGF) signals by modulating the intracellular localization of NGF receptors and membrane fluidity in PC12 cells.	G(M1) Ganglioside	14-17	nerve growth factor	Rattus norvegicus	50-53
15145933-0	2004	Overexpressed GM1 suppresses nerve growth factor (NGF) signals by modulating the intracellular localization of NGF receptors and membrane fluidity in PC12 cells.	G(M1) Ganglioside	14-17	nerve growth factor	Rattus norvegicus	111-114
15145933-4	2004	Autophosphorylation of NGF receptor TrkA and activation of ERK1/2 after NGF treatment were scarcely detected in GM1+ cells.	G(M1) Ganglioside	112-116	nerve growth factor	Rattus norvegicus	23-26
15145933-6	2004	However, dimer formation of TrkA upon NGF treatment was markedly suppressed in GM1+ cells in both cross-linking analysis with Bis(sulfosuccinimidyl)suberate 3 and 125I-NGF binding assay.	G(M1) Ganglioside	79-82	nerve growth factor	Rattus norvegicus	38-41
15145933-6	2004	However, dimer formation of TrkA upon NGF treatment was markedly suppressed in GM1+ cells in both cross-linking analysis with Bis(sulfosuccinimidyl)suberate 3 and 125I-NGF binding assay.	G(M1) Ganglioside	79-82	nerve growth factor	Rattus norvegicus	168-171
15145933-9	2004	TrkA kinase activity was differentially regulated when GM1 was added to the kinase assay system in vitro, suggesting suppressive/enhancing effects of GM1 on NGF signals based on the concentration.	G(M1) Ganglioside	55-58	nerve growth factor	Rattus norvegicus	157-160
15145933-9	2004	TrkA kinase activity was differentially regulated when GM1 was added to the kinase assay system in vitro, suggesting suppressive/enhancing effects of GM1 on NGF signals based on the concentration.	G(M1) Ganglioside	150-153	nerve growth factor	Rattus norvegicus	157-160
15145933-11	2004	These results suggested that overexpressed GM1 suppresses the differentiation signals mediated by NGF/TrkA by modulating the properties of the lipid raft and the intracellular localization of NGF receptors and relevant signaling molecules.	G(M1) Ganglioside	43-46	nerve growth factor	Rattus norvegicus	98-101
15145933-11	2004	These results suggested that overexpressed GM1 suppresses the differentiation signals mediated by NGF/TrkA by modulating the properties of the lipid raft and the intracellular localization of NGF receptors and relevant signaling molecules.	G(M1) Ganglioside	43-46	nerve growth factor	Rattus norvegicus	192-195
15487588-1	2004	GM1 gangliosidosis is a progressive neurodegenerative disease caused by deficiencies in lysosomal acid beta-galactosidase (beta-gal) and involves accumulation and storage of ganglioside GM1 and its asialo form (GA1) in brain and visceral tissues.	G(M1) Ganglioside	0-3	galactosidase, beta 1	Mus musculus	103-111
15487588-2	2004	Similar to the infantile/juvenile human disease forms, B6/129Sv beta-gal knockout (ko) mice express residual tissue beta-gal activity and significant elevations of brain GM1, GA1, and total gangliosides.	G(M1) Ganglioside	170-173	galactosidase, beta 1	Mus musculus	64-72
15213113-5	2004	We show that the receptor for Afa/Dr adhesins, glycosylphosphatidylinositol-anchored CD55; the raft marker, ganglioside GM1; and VIP21/caveolin are all recruited around adhering Dr-positive bacteria.	G(M1) Ganglioside	120-123	AFA	Homo sapiens	30-33
15170821-9	2004	Furthermore, while overexpression of sigma-1R increases the level of lipid raft-associated cholesterol, the overexpression alters the levels of gangliosides in lipid rafts: GM1 and GM2 are decreased, whereas GD1a is increased.	G(M1) Ganglioside	173-176	sigma non-opioid intracellular receptor 1	Rattus norvegicus	37-45
15152051-2	2004	We hypothesized previously that GM1 ganglioside-bound Abeta (GAbeta) is involved in the process.	G(M1) Ganglioside	32-35	alpha glucosidase	Homo sapiens	61-67
15169623-6	2004	(3) GM1 downregulated the temporally high expression of NMDAR1 in the hippocampal slices immediately after a 25-min OGD and prevented the over low expression of NMDAR1 after a 30-min reperfusion.	G(M1) Ganglioside	4-7	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	56-62
15169623-6	2004	(3) GM1 downregulated the temporally high expression of NMDAR1 in the hippocampal slices immediately after a 25-min OGD and prevented the over low expression of NMDAR1 after a 30-min reperfusion.	G(M1) Ganglioside	4-7	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	161-167
15169623-7	2004	CONCLUSION: GM1 could protect injuried rat hippocampal slices after OGD/RP through stabilizing the expression of NMDAR1.	G(M1) Ganglioside	12-15	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	113-119
15034144-6	2004	In contrast, external cross-linking of FcepsilonRI and GM1 causes their redistribution to electron-dense membrane patches independently of each other and of Thy-1.	G(M1) Ganglioside	55-58	Thy-1 cell surface antigen	Homo sapiens	157-162
15079865-1	2004	Previous work demonstrated the presence of an isoform of Na(+)/Ca(2+) exchanger in the nuclear envelope of neurons and NG108-15 cells that is tightly associated with GM1 ganglioside and potentiated by the latter.	G(M1) Ganglioside	166-181	solute carrier family 8 member A1	Homo sapiens	57-79
15293557-3	2004	In the present study, we evaluate the effects of the systemic administration of GM1 on the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and on spontaneous chemiluminescence and total radical-trapping potential (TRAP) in cerebral cortex of rats ex vivo.	G(M1) Ganglioside	80-83	catalase	Rattus norvegicus	131-139
15293557-3	2004	In the present study, we evaluate the effects of the systemic administration of GM1 on the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and on spontaneous chemiluminescence and total radical-trapping potential (TRAP) in cerebral cortex of rats ex vivo.	G(M1) Ganglioside	80-83	catalase	Rattus norvegicus	141-144
15293557-9	2004	GM1 administration reduced spontaneous chemiluminescence and increased catalase activity ex vivo, but had no effect on TRAP, SOD or GSH-Px activities.	G(M1) Ganglioside	0-3	catalase	Rattus norvegicus	71-79
15293557-11	2004	We suggest that the antioxidant activity of GM1 ganglioside in the cerebral cortex may be due to an increased catalase activity.	G(M1) Ganglioside	44-59	catalase	Rattus norvegicus	110-118
15079865-2	2004	This contrasted with the Na(+)/Ca(2+) exchanger(s) in the plasma membrane, which were suggested to associate more loosely with GM1.	G(M1) Ganglioside	127-130	solute carrier family 8 member A1	Homo sapiens	25-47
15079865-8	2004	Culturing of C6 cells in the presence dibutyryl-cAMP caused upregulation of a high molecular weight isoform of the exchanger together with GM1 in the nuclear envelope, resulting in significant elevation of Na(+)/Ca(2+) exchanger activity in the latter.	G(M1) Ganglioside	139-142	solute carrier family 8 member A1	Homo sapiens	206-228
15079865-10	2004	The Na(+)/Ca(2+) exchanger/GM1 complex occurs in the inner membrane of the nuclear envelope, suggesting a functional role in transferring Ca(2+) between nucleoplasm and the envelope lumen.	G(M1) Ganglioside	27-30	solute carrier family 8 member A1	Homo sapiens	4-26
14709559-1	2004	In order to investigate the influence of cholesterol (Ch) and monosialoganglioside (GM1) on the release and subsequent deposition/aggregation of amyloid beta peptide (Abeta)-(1-40) and Abeta-(1-42), we have examined Abeta peptide model membrane interactions by circular dichroism, turbidity measurements, and transmission electron microscopy (TEM).	G(M1) Ganglioside	84-87	amyloid beta precursor protein	Homo sapiens	167-172
14709559-9	2004	Our results suggest a possible role for both Ch and GM1 in the membrane release of Abeta from brain lipid bilayers.	G(M1) Ganglioside	52-55	amyloid beta precursor protein	Homo sapiens	83-88
14709559-1	2004	In order to investigate the influence of cholesterol (Ch) and monosialoganglioside (GM1) on the release and subsequent deposition/aggregation of amyloid beta peptide (Abeta)-(1-40) and Abeta-(1-42), we have examined Abeta peptide model membrane interactions by circular dichroism, turbidity measurements, and transmission electron microscopy (TEM).	G(M1) Ganglioside	84-87	amyloid beta precursor protein	Homo sapiens	185-190
14709559-1	2004	In order to investigate the influence of cholesterol (Ch) and monosialoganglioside (GM1) on the release and subsequent deposition/aggregation of amyloid beta peptide (Abeta)-(1-40) and Abeta-(1-42), we have examined Abeta peptide model membrane interactions by circular dichroism, turbidity measurements, and transmission electron microscopy (TEM).	G(M1) Ganglioside	84-87	amyloid beta precursor protein	Homo sapiens	185-190
15051759-2	2004	Patches of cross-linked raft resident ganglioside GM1 colocalized with ULBP1, 2, 3, or MICA, but not CD45.	G(M1) Ganglioside	50-53	UL16 binding protein 1	Homo sapiens	71-82
15051759-2	2004	Patches of cross-linked raft resident ganglioside GM1 colocalized with ULBP1, 2, 3, or MICA, but not CD45.	G(M1) Ganglioside	50-53	MHC class I polypeptide-related sequence A	Homo sapiens	87-91
15051759-4	2004	Western blotting revealed that glycosylphosphatidylinositol (GPI)-anchored ULBP3 but not transmembrane MICA, MHC class I protein, or transferrin receptor, accumulated in detergent-resistant membranes containing GM1.	G(M1) Ganglioside	211-214	UL16 binding protein 3	Homo sapiens	75-80
15085197-4	2004	Our results indicate that the expression of raft-associated ganglioside, GM1, is increased in T cells from SLE patients and LCK may be differentially regulated due to an alteration in the association of CD45 with lipid raft domains.	G(M1) Ganglioside	73-76	protein tyrosine phosphatase receptor type C	Homo sapiens	203-207
14985092-0	2004	Conformational alteration of bradykinin in presence of GM1 micelle.	G(M1) Ganglioside	55-58	kininogen 1	Homo sapiens	29-39
14985092-1	2004	We report here the interaction of bradykinin with ganglioside GM1 by circular dichroism, steady-state fluorescence, and one-dimensional 1H NMR spectroscopy.	G(M1) Ganglioside	62-65	kininogen 1	Homo sapiens	34-44
14985092-2	2004	Circular dichroism spectroscopy is indicative of a turn formation of bradykinin backbone in the presence of GM1 micelle.	G(M1) Ganglioside	108-111	kininogen 1	Homo sapiens	69-79
15002743-3	2004	Ganglioside GM1 binds tightly with Abeta and it is speculated that GM1 inhibits Abeta from undergoing alpha-helix to beta-sheet conformational changes.	G(M1) Ganglioside	12-15	amyloid beta precursor protein	Homo sapiens	35-40
14764879-3	2004	MT stabilization also involved FAK-regulated localization of a lipid raft marker, ganglioside GM1, to the leading edge.	G(M1) Ganglioside	82-97	protein tyrosine kinase 2	Homo sapiens	31-34
14764879-4	2004	The integrin-FAK signaling pathway may facilitate Rho-mDia signaling through GM1, or through a specialized membrane domain containing GM1, to stabilize MTs in the leading edge of migrating cells.	G(M1) Ganglioside	77-80	protein tyrosine kinase 2	Homo sapiens	13-16
14764879-4	2004	The integrin-FAK signaling pathway may facilitate Rho-mDia signaling through GM1, or through a specialized membrane domain containing GM1, to stabilize MTs in the leading edge of migrating cells.	G(M1) Ganglioside	134-137	protein tyrosine kinase 2	Homo sapiens	13-16
15019948-4	2004	After transfection in HEK293 cells, Hip partitions with the raft component ganglioside GM1 during density gradient centrifugation.	G(M1) Ganglioside	75-90	hedgehog interacting protein	Homo sapiens	36-39
15002743-3	2004	Ganglioside GM1 binds tightly with Abeta and it is speculated that GM1 inhibits Abeta from undergoing alpha-helix to beta-sheet conformational changes.	G(M1) Ganglioside	12-15	amyloid beta precursor protein	Homo sapiens	80-85
15002743-3	2004	Ganglioside GM1 binds tightly with Abeta and it is speculated that GM1 inhibits Abeta from undergoing alpha-helix to beta-sheet conformational changes.	G(M1) Ganglioside	67-70	amyloid beta precursor protein	Homo sapiens	80-85
14713197-7	2003	The GM1-ELISA binding assay indicated that chloroplast-synthesized LTB protein bound to GM1-ganglioside receptors.	G(M1) Ganglioside	4-7	lymphotoxin beta	Homo sapiens	67-70
15063003-0	2004	Aggregation of liposomes induced by the toxic peptides Alzheimer"s Abetas, human amylin and prion (106-126): facilitation by membrane-bound GM1 ganglioside.	G(M1) Ganglioside	140-155	islet amyloid polypeptide	Homo sapiens	81-87
14674750-0	2003	Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins.	G(M1) Ganglioside	76-91	galectin 1	Homo sapiens	61-71
14674750-3	2003	Using the growth-regulatory interaction of the pentasaccharide of ganglioside GM(1) with homodimeric galectin-1 on neuroblastoma cell surfaces as a model, we present a suitable strategy for addressing this issue.	G(M1) Ganglioside	78-83	galectin 1	Homo sapiens	101-111
14630342-1	2003	PC12 cells undergo neuritogenesis upon nerve growth factor (NGF) activation of the TrkA receptor, an effect mimicked by the ganglioside GM1 binding B-subunit of cholera toxin (CTB).	G(M1) Ganglioside	136-139	neurotrophic receptor tyrosine kinase 1	Homo sapiens	83-87
14630342-1	2003	PC12 cells undergo neuritogenesis upon nerve growth factor (NGF) activation of the TrkA receptor, an effect mimicked by the ganglioside GM1 binding B-subunit of cholera toxin (CTB).	G(M1) Ganglioside	136-139	phosphate cytidylyltransferase 1B, choline	Homo sapiens	176-179
14630342-8	2003	These data indicate that GM1/ligand interaction does not necessarily lead to neuritogenesis and suggest that a specialisation of CTB, not shared by anti-GM1 antibodies or rETxB, is required to activate TrkA.	G(M1) Ganglioside	25-28	neurotrophic receptor tyrosine kinase 1	Homo sapiens	202-206
12974752-5	2003	Mechanistically we found that uptake or transport of insulin-CTB conjugates in the gut occurs at least partially via binding to GM-1, which would explain the enhanced clinical efficacy.	G(M1) Ganglioside	128-132	insulin	Homo sapiens	53-60
12974752-5	2003	Mechanistically we found that uptake or transport of insulin-CTB conjugates in the gut occurs at least partially via binding to GM-1, which would explain the enhanced clinical efficacy.	G(M1) Ganglioside	128-132	phosphate cytidylyltransferase 1B, choline	Homo sapiens	61-64
12925761-8	2003	Fluorescent GM1, normally internalized by clathrin-independent endocytosis in HeLa cells with low cav-1, was induced to partially internalize via the clathrin pathway in the presence of CtxB.	G(M1) Ganglioside	12-15	caveolin 1	Homo sapiens	98-103
12960303-5	2003	However, enforced expression of the costimulatory molecule CD80 on thymic epithelium induced GM1 polarization in thymocytes, and was accompanied by reduced positive selection and increased apoptosis.	G(M1) Ganglioside	93-96	CD80 molecule	Homo sapiens	59-63
12921760-6	2003	Stimulation of primary human CD4(+) T cells leads to increased GM1 and flotillin-1 expression in the surface membrane, where these components colocalize.	G(M1) Ganglioside	63-66	CD4 molecule	Homo sapiens	29-32
12921760-9	2003	In this regard, we observed an increase in the raft-associated gangliolipid, GM1, in resting human CD4(+) and CD8(+) lymphocytes with aging.	G(M1) Ganglioside	77-80	CD4 molecule	Homo sapiens	99-102
12921760-9	2003	In this regard, we observed an increase in the raft-associated gangliolipid, GM1, in resting human CD4(+) and CD8(+) lymphocytes with aging.	G(M1) Ganglioside	77-80	CD8a molecule	Homo sapiens	110-113
12763926-9	2003	On mAb binding, CD38 translocates to the membrane lipid microdomains, as shown by a colocalization with the GM1 ganglioside and with CD81, a raft-resident protein.	G(M1) Ganglioside	108-123	CD38 molecule	Homo sapiens	16-20
14574626-1	2003	Regarding deposition of amyloid beta-protein (Abeta) in brains with Alzheimer"s disease (AD), we previously identified a novel Abeta species that strongly binds to GM1 ganglioside (GM1) in human brains that exhibit early pathological changes of AD.	G(M1) Ganglioside	164-179	amyloid beta precursor protein	Homo sapiens	46-51
14574626-1	2003	Regarding deposition of amyloid beta-protein (Abeta) in brains with Alzheimer"s disease (AD), we previously identified a novel Abeta species that strongly binds to GM1 ganglioside (GM1) in human brains that exhibit early pathological changes of AD.	G(M1) Ganglioside	164-179	amyloid beta precursor protein	Homo sapiens	127-132
14574626-1	2003	Regarding deposition of amyloid beta-protein (Abeta) in brains with Alzheimer"s disease (AD), we previously identified a novel Abeta species that strongly binds to GM1 ganglioside (GM1) in human brains that exhibit early pathological changes of AD.	G(M1) Ganglioside	164-167	amyloid beta precursor protein	Homo sapiens	46-51
14574626-1	2003	Regarding deposition of amyloid beta-protein (Abeta) in brains with Alzheimer"s disease (AD), we previously identified a novel Abeta species that strongly binds to GM1 ganglioside (GM1) in human brains that exhibit early pathological changes of AD.	G(M1) Ganglioside	164-167	amyloid beta precursor protein	Homo sapiens	127-132
14574626-2	2003	We hypothesized that Abeta undergoes conformational alteration through its binding to GM1 and acts as a seed.	G(M1) Ganglioside	86-89	amyloid beta precursor protein	Homo sapiens	21-26
14574626-3	2003	We recently found that an increase in the cholesterol concentration in host membranes markedly accelerates Abeta binding to GM1.	G(M1) Ganglioside	124-127	amyloid beta precursor protein	Homo sapiens	107-112
12884293-0	2003	Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells.	G(M1) Ganglioside	83-86	vav guanine nucleotide exchange factor 1	Homo sapiens	0-3
12884293-0	2003	Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells.	G(M1) Ganglioside	83-86	Nef	Human immunodeficiency virus 1	42-45
12884293-3	2003	These observations suggest that Nef can modify plasma membrane GM1, affecting the behavior of HIV-infected cells towards antigen recognition and Vav towards counteracting such an effect.	G(M1) Ganglioside	63-66	S100 calcium binding protein B	Homo sapiens	32-35
12884293-4	2003	We observed that Nef expression, either following viral infection or ectopic expression, significantly decreased the level of plasma membrane GM1 in unstimulated T cells.	G(M1) Ganglioside	142-145	Neuropeptide-like precursor 2	Drosophila melanogaster	17-20
12884293-7	2003	Our evidence that Vav overexpression counteracted both the Nef-induced decrease of GM1 expression and the inhibition of NF-AT activity, suggests a novel mechanism by which Nef may interfere with TCR-mediated activation through the modulation of intracellular trafficking and clustering of GM1-enriched microdomains at the cell surface.	G(M1) Ganglioside	83-86	vav guanine nucleotide exchange factor 1	Homo sapiens	18-21
12884293-7	2003	Our evidence that Vav overexpression counteracted both the Nef-induced decrease of GM1 expression and the inhibition of NF-AT activity, suggests a novel mechanism by which Nef may interfere with TCR-mediated activation through the modulation of intracellular trafficking and clustering of GM1-enriched microdomains at the cell surface.	G(M1) Ganglioside	83-86	S100 calcium binding protein B	Homo sapiens	59-62
12884293-7	2003	Our evidence that Vav overexpression counteracted both the Nef-induced decrease of GM1 expression and the inhibition of NF-AT activity, suggests a novel mechanism by which Nef may interfere with TCR-mediated activation through the modulation of intracellular trafficking and clustering of GM1-enriched microdomains at the cell surface.	G(M1) Ganglioside	83-86	S100 calcium binding protein B	Homo sapiens	172-175
12884293-7	2003	Our evidence that Vav overexpression counteracted both the Nef-induced decrease of GM1 expression and the inhibition of NF-AT activity, suggests a novel mechanism by which Nef may interfere with TCR-mediated activation through the modulation of intracellular trafficking and clustering of GM1-enriched microdomains at the cell surface.	G(M1) Ganglioside	83-86	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	195-198
12884293-7	2003	Our evidence that Vav overexpression counteracted both the Nef-induced decrease of GM1 expression and the inhibition of NF-AT activity, suggests a novel mechanism by which Nef may interfere with TCR-mediated activation through the modulation of intracellular trafficking and clustering of GM1-enriched microdomains at the cell surface.	G(M1) Ganglioside	289-292	vav guanine nucleotide exchange factor 1	Homo sapiens	18-21
12884293-7	2003	Our evidence that Vav overexpression counteracted both the Nef-induced decrease of GM1 expression and the inhibition of NF-AT activity, suggests a novel mechanism by which Nef may interfere with TCR-mediated activation through the modulation of intracellular trafficking and clustering of GM1-enriched microdomains at the cell surface.	G(M1) Ganglioside	289-292	S100 calcium binding protein B	Homo sapiens	59-62
12884293-7	2003	Our evidence that Vav overexpression counteracted both the Nef-induced decrease of GM1 expression and the inhibition of NF-AT activity, suggests a novel mechanism by which Nef may interfere with TCR-mediated activation through the modulation of intracellular trafficking and clustering of GM1-enriched microdomains at the cell surface.	G(M1) Ganglioside	289-292	S100 calcium binding protein B	Homo sapiens	172-175
12884293-7	2003	Our evidence that Vav overexpression counteracted both the Nef-induced decrease of GM1 expression and the inhibition of NF-AT activity, suggests a novel mechanism by which Nef may interfere with TCR-mediated activation through the modulation of intracellular trafficking and clustering of GM1-enriched microdomains at the cell surface.	G(M1) Ganglioside	289-292	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	195-198
12730204-7	2003	In fact, accumulation of GM1 and GM2, the possible sialidase products in transgenic tissues, caused inhibition of IR phosphorylation in vitro, and blocking of association with Grb2 resulted in reversion of impaired insulin signaling in L6 cells.	G(M1) Ganglioside	25-28	insulin receptor	Mus musculus	114-116
12763482-7	2003	EMP2 expression increased the surface levels of MHC1, CD54, and GM1 glycolipids.	G(M1) Ganglioside	64-67	epithelial membrane protein 2	Homo sapiens	0-4
12734199-7	2003	In MCF-7 cells, OS increases the intracellular concentration of sphingomyelin and other phospholipids and induces the translocation of the small GTPase p21Ras to GM1- and cholesterol-rich membrane areas.	G(M1) Ganglioside	162-165	HRas proto-oncogene, GTPase	Homo sapiens	152-158
12803922-5	2003	Overexpression of wild-type rab7 or rab9 (but not rab11) in Niemann-Pick C fibroblasts results in correction of lipid trafficking defects, including restoration of Golgi targeting of fluorescent lactosylceramide and endogenous GM1 ganglioside (monitored by the transport of fluorescent cholera toxin), and a dramatic reduction in accumulation of intracellular cholesterol.	G(M1) Ganglioside	227-242	RAB7B, member RAS oncogene family	Homo sapiens	28-32
12803922-5	2003	Overexpression of wild-type rab7 or rab9 (but not rab11) in Niemann-Pick C fibroblasts results in correction of lipid trafficking defects, including restoration of Golgi targeting of fluorescent lactosylceramide and endogenous GM1 ganglioside (monitored by the transport of fluorescent cholera toxin), and a dramatic reduction in accumulation of intracellular cholesterol.	G(M1) Ganglioside	227-242	RAB9A, member RAS oncogene family	Homo sapiens	36-40
12805216-5	2003	Disruption of the Raftlin gene in the DT40 B-cell line resulted in a marked reduction in the quantity of lipid raft components, including Lyn and ganglioside GM1, while overexpression of Raftlin increased the content of raft protein.	G(M1) Ganglioside	158-161	raftlin, lipid raft linker 1	Homo sapiens	18-25
12794125-3	2003	The anergic cells showed a displacement of the CD4-p56(lck) signaling module from the GM1-rich plasma membrane microdomains (lipid rafts), and subsequently an increase in p59(fyn) kinase activity, a dominant expression of p21 inhibitory TCR zeta-chain, and a poor phosphorylation and recruitment of zeta-associated protein of 70 kDa kinase to the TCR"s immunoreceptor tyrosine-based activation motifs.	G(M1) Ganglioside	86-89	CD4 molecule	Homo sapiens	47-50
12794125-3	2003	The anergic cells showed a displacement of the CD4-p56(lck) signaling module from the GM1-rich plasma membrane microdomains (lipid rafts), and subsequently an increase in p59(fyn) kinase activity, a dominant expression of p21 inhibitory TCR zeta-chain, and a poor phosphorylation and recruitment of zeta-associated protein of 70 kDa kinase to the TCR"s immunoreceptor tyrosine-based activation motifs.	G(M1) Ganglioside	86-89	cyclin dependent kinase like 2	Homo sapiens	51-54
12794125-3	2003	The anergic cells showed a displacement of the CD4-p56(lck) signaling module from the GM1-rich plasma membrane microdomains (lipid rafts), and subsequently an increase in p59(fyn) kinase activity, a dominant expression of p21 inhibitory TCR zeta-chain, and a poor phosphorylation and recruitment of zeta-associated protein of 70 kDa kinase to the TCR"s immunoreceptor tyrosine-based activation motifs.	G(M1) Ganglioside	86-89	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-58
12743241-3	2003	RESULTS: Frequent anti-GM1 antibody subclasses were IgG1 (76%) and IgG3 (31%).	G(M1) Ganglioside	23-26	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	67-71
12681511-0	2003	Engagement of CD99 triggers the exocytic transport of ganglioside GM1 and the reorganization of actin cytoskeleton.	G(M1) Ganglioside	66-69	CD99 molecule (Xg blood group)	Homo sapiens	14-18
12681284-3	2003	Software was developed to objectively quantitate colocalisation and was used to show that plasma membrane PI(4,5)P(2) was enriched in lipid raft-containing patches of GM1 ganglioside, formed by crosslinking cholera toxin B-subunit (CT-B).	G(M1) Ganglioside	167-182	phosphate cytidylyltransferase 1B, choline	Homo sapiens	207-230
12699627-4	2003	This study employs fluorescence resonance energy transfer (FRET) to show that in the plasma membrane (PM) of living cells the glycosphingolipid GM1, labeled with cholera toxin B subunit (CTB) [9,10], is found at least in part within clusters that also include GPI-linked proteins.	G(M1) Ganglioside	144-147	kelch like family member 42	Homo sapiens	162-194
12681511-2	2003	CD99 engagement in Jurkat cells elicited the exocytic transport of GM1 as well as several surface molecules closely related with CD99 functions.	G(M1) Ganglioside	67-70	CD99 molecule (Xg blood group)	Homo sapiens	0-4
12681511-4	2003	Association of CD99 with actin cytoskeleton was inhibited by methyl-beta-cyclodextrin, while CD99-mediated GM1 clustering was inhibited by cytochalasin D. Therefore, we suggest that CD99 may play a role in the vesicular transport of transmembrane proteins and lipid rafts from the intracellular location to the cell surface, possibly by effecting actin cytoskeleton reorganization.	G(M1) Ganglioside	107-110	CD99 molecule (Xg blood group)	Homo sapiens	93-97
12681511-4	2003	Association of CD99 with actin cytoskeleton was inhibited by methyl-beta-cyclodextrin, while CD99-mediated GM1 clustering was inhibited by cytochalasin D. Therefore, we suggest that CD99 may play a role in the vesicular transport of transmembrane proteins and lipid rafts from the intracellular location to the cell surface, possibly by effecting actin cytoskeleton reorganization.	G(M1) Ganglioside	107-110	CD99 molecule (Xg blood group)	Homo sapiens	93-97
12641744-6	2003	Remarkably, TAG-1 was cross-linked in a similar extent by the photoactivated ganglioside GM3, GM1 and GD1b.	G(M1) Ganglioside	94-97	contactin 2	Homo sapiens	12-17
12667680-3	2003	Herein, we describe a strategy for detecting fine alterations in the amount and distribution of glycosphingolipid (GM1) lipid rafts, and in the formation of GM1-TCR complexes in detergent-insoluble and -soluble compartments of the T cell membrane from a relative low number of cells.	G(M1) Ganglioside	157-160	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	161-164
12667680-4	2003	Using this strategy, we found that the GM1 moiety was physically associated with TCR in both detergent-insoluble and -soluble fractions.	G(M1) Ganglioside	39-42	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	81-84
12659848-3	2003	In this study, using fluorescence resonance energy transfer, we found that after A beta binds to raft-like membranes composed of monosialoganglioside GM1/cholesterol/sphingomyelin (1/1/1), the protein can translocate to the phosphatidylcholine membranes to which soluble A beta does not bind.	G(M1) Ganglioside	150-153	amyloid beta precursor protein	Homo sapiens	81-87
12657617-0	2003	Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve.	G(M1) Ganglioside	31-34	rolled	Drosophila melanogaster	14-18
12657617-0	2003	Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve.	G(M1) Ganglioside	31-34	Cyclic-AMP response element binding protein A	Drosophila melanogaster	23-27
12657617-9	2003	In addition, GM1 enhanced the activation of MAPK and CREB with the treatment of GM1 in the retina with axotomized nerve.	G(M1) Ganglioside	13-16	rolled	Drosophila melanogaster	44-48
12657617-9	2003	In addition, GM1 enhanced the activation of MAPK and CREB with the treatment of GM1 in the retina with axotomized nerve.	G(M1) Ganglioside	13-16	Cyclic-AMP response element binding protein A	Drosophila melanogaster	53-57
12657617-9	2003	In addition, GM1 enhanced the activation of MAPK and CREB with the treatment of GM1 in the retina with axotomized nerve.	G(M1) Ganglioside	80-83	rolled	Drosophila melanogaster	44-48
12657617-10	2003	Treatment of MAPK inhibitor PD98059 with GM1 reduced the protective action of GM1 and prevented GM1-induced phosphorylation of CREB.	G(M1) Ganglioside	41-44	rolled	Drosophila melanogaster	13-17
12657617-10	2003	Treatment of MAPK inhibitor PD98059 with GM1 reduced the protective action of GM1 and prevented GM1-induced phosphorylation of CREB.	G(M1) Ganglioside	41-44	Cyclic-AMP response element binding protein A	Drosophila melanogaster	127-131
12657617-10	2003	Treatment of MAPK inhibitor PD98059 with GM1 reduced the protective action of GM1 and prevented GM1-induced phosphorylation of CREB.	G(M1) Ganglioside	78-81	rolled	Drosophila melanogaster	13-17
12657617-10	2003	Treatment of MAPK inhibitor PD98059 with GM1 reduced the protective action of GM1 and prevented GM1-induced phosphorylation of CREB.	G(M1) Ganglioside	78-81	rolled	Drosophila melanogaster	13-17
12657617-11	2003	CONCLUSIONS: GM1 protected the axotomized retinal ganglion cells (RGCs) from cell death after axotomy through the activation of MAPK and CREB.	G(M1) Ganglioside	13-16	rolled	Drosophila melanogaster	128-132
12657617-11	2003	CONCLUSIONS: GM1 protected the axotomized retinal ganglion cells (RGCs) from cell death after axotomy through the activation of MAPK and CREB.	G(M1) Ganglioside	13-16	Cyclic-AMP response element binding protein A	Drosophila melanogaster	137-141
12445726-6	2002	Cholera toxin B subunit (CTB) is a specific ligand for ganglioside GM1 and can be used for the detection of GM1 containing DRM.	G(M1) Ganglioside	55-70	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-23
12794304-0	2003	Domain-dependent modulation of PDGFRbeta by ganglioside GM1.	G(M1) Ganglioside	56-59	platelet derived growth factor receptor, beta polypeptide	Mus musculus	31-40
12794304-3	2003	The addition of ganglioside GM1 to the medium of Swiss 3T3 fibroblasts inhibits both platelet-derived growth factor (PDGF)-mediated tyrosine phosphorylation of PDGF receptor beta (PDGFRbeta) and receptor-mediated endocytosis.	G(M1) Ganglioside	16-31	platelet derived growth factor receptor, beta polypeptide	Mus musculus	180-189
12687620-5	2003	The ganglioside GM1 colocalized on the plasma membrane with the raft markers flotillin 1 and 2, which were enriched in low buoyant density fractions containing 52 identifiable proteins, 28 of which have not been reported in rafts, and nine of which are associated with the endoplasmic reticulum (ER).	G(M1) Ganglioside	16-19	flotillin 1	Homo sapiens	77-94
12499380-6	2003	Coimmunoprecipitation experiments demonstrated that GM3 and GM1 were immunoprecipitated by anti-caspase-8 only after triggering through CD95/Fas.	G(M1) Ganglioside	60-63	caspase 8	Homo sapiens	96-105
12499380-6	2003	Coimmunoprecipitation experiments demonstrated that GM3 and GM1 were immunoprecipitated by anti-caspase-8 only after triggering through CD95/Fas.	G(M1) Ganglioside	60-63	Fas cell surface death receptor	Homo sapiens	136-140
12635116-2	2003	A previous report on a patient who had a neuropathy with immunoglobulin M (IgM) M-protein binding to a conformational epitope formed by phosphatidic acid (PA) and gangliosides prompted us to investigate the binding of IgG antibodies in GBS sera to a mixture of GM1 and PA (GM1/PA).	G(M1) Ganglioside	261-264	myomesin 2	Homo sapiens	80-89
12635116-2	2003	A previous report on a patient who had a neuropathy with immunoglobulin M (IgM) M-protein binding to a conformational epitope formed by phosphatidic acid (PA) and gangliosides prompted us to investigate the binding of IgG antibodies in GBS sera to a mixture of GM1 and PA (GM1/PA).	G(M1) Ganglioside	273-276	myomesin 2	Homo sapiens	80-89
12388556-2	2002	GM1 induced autophosphorylation of TrkC more potently than TrkA or TrkB receptors.	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 3	Homo sapiens	35-39
12388556-4	2002	Therefore, Scatchard analysis was performed to determine whether GM1 binds to TrkC.	G(M1) Ganglioside	65-68	neurotrophic receptor tyrosine kinase 3	Homo sapiens	78-82
12794304-5	2003	The ability of GM1 to modulate PDGFRbeta in 3T3 cells but not in transfected PC12 cells indicates a cell context-dependent response.	G(M1) Ganglioside	15-18	platelet derived growth factor receptor, beta polypeptide	Mus musculus	31-40
12794304-6	2003	We hypothesized that this inhibition of PDGFRbeta by GM1 must map to one or more domains of the receptor.	G(M1) Ganglioside	53-56	platelet derived growth factor receptor, beta polypeptide	Mus musculus	40-49
12794304-9	2003	GM1 still inhibited PDGF-mediated tyrosine phosphorylation of endogenous PDGFRbeta and of Erk1/2 in Swiss TTbeta cells.	G(M1) Ganglioside	0-3	platelet derived growth factor receptor, beta polypeptide	Mus musculus	73-82
12794304-9	2003	GM1 still inhibited PDGF-mediated tyrosine phosphorylation of endogenous PDGFRbeta and of Erk1/2 in Swiss TTbeta cells.	G(M1) Ganglioside	0-3	mitogen-activated protein kinase 3	Mus musculus	90-96
12794304-11	2003	This suggests that the inhibition of PDGFRbeta by GM1 in Swiss 3T3 fibroblasts maps to either the extracellular and/or transmembrane domain of PDGFRbeta.	G(M1) Ganglioside	50-53	platelet derived growth factor receptor, beta polypeptide	Mus musculus	37-46
12794304-11	2003	This suggests that the inhibition of PDGFRbeta by GM1 in Swiss 3T3 fibroblasts maps to either the extracellular and/or transmembrane domain of PDGFRbeta.	G(M1) Ganglioside	50-53	platelet derived growth factor receptor, beta polypeptide	Mus musculus	143-152
12663787-5	2003	However, Pr55(gag) might nevertheless be a raft-associated protein, since confocal fluorescence microscopy indicated that coalescence of GM1-positive rafts at the cell surface led to copatching of membrane-bound Pr55(gag).	G(M1) Ganglioside	137-140	Pr55(Gag)	Human immunodeficiency virus 1	14-17
12470704-2	2003	After 1h of incubation, GM1 stably bound to synaptosomes and modified the activity of the neuronal dopamine transporter (DAT).	G(M1) Ganglioside	24-27	solute carrier family 6 member 3	Rattus norvegicus	99-119
12470704-2	2003	After 1h of incubation, GM1 stably bound to synaptosomes and modified the activity of the neuronal dopamine transporter (DAT).	G(M1) Ganglioside	24-27	solute carrier family 6 member 3	Rattus norvegicus	121-124
12573454-9	2003	A GS fraction in IBM showed a GM(1)-specific binding to cholera toxin subunit B (CTB).	G(M1) Ganglioside	30-35	phosphate cytidylyltransferase 1B, choline	Homo sapiens	56-79
12573454-9	2003	A GS fraction in IBM showed a GM(1)-specific binding to cholera toxin subunit B (CTB).	G(M1) Ganglioside	30-35	phosphate cytidylyltransferase 1B, choline	Homo sapiens	81-84
12388556-8	2002	GM1 induced a rapid and significant increase in the amount of neurotrophin-3, but not other neurotrophins.	G(M1) Ganglioside	0-3	neurotrophin 3	Homo sapiens	62-76
12388556-10	2002	Moreover, GM1-mediated TrkC autophosphorylation was blocked by TrkC-IgG (but not TrkB-IgG) receptor bodies, further suggesting that GM1 activates TrkC by inducing the release of neurotrophin-3.	G(M1) Ganglioside	10-13	neurotrophic receptor tyrosine kinase 3	Homo sapiens	23-27
12388556-10	2002	Moreover, GM1-mediated TrkC autophosphorylation was blocked by TrkC-IgG (but not TrkB-IgG) receptor bodies, further suggesting that GM1 activates TrkC by inducing the release of neurotrophin-3.	G(M1) Ganglioside	10-13	neurotrophic receptor tyrosine kinase 3	Homo sapiens	63-67
12388556-10	2002	Moreover, GM1-mediated TrkC autophosphorylation was blocked by TrkC-IgG (but not TrkB-IgG) receptor bodies, further suggesting that GM1 activates TrkC by inducing the release of neurotrophin-3.	G(M1) Ganglioside	10-13	neurotrophic receptor tyrosine kinase 3	Homo sapiens	63-67
12388556-10	2002	Moreover, GM1-mediated TrkC autophosphorylation was blocked by TrkC-IgG (but not TrkB-IgG) receptor bodies, further suggesting that GM1 activates TrkC by inducing the release of neurotrophin-3.	G(M1) Ganglioside	10-13	neurotrophin 3	Homo sapiens	178-192
12388556-10	2002	Moreover, GM1-mediated TrkC autophosphorylation was blocked by TrkC-IgG (but not TrkB-IgG) receptor bodies, further suggesting that GM1 activates TrkC by inducing the release of neurotrophin-3.	G(M1) Ganglioside	132-135	neurotrophic receptor tyrosine kinase 3	Homo sapiens	23-27
12388556-10	2002	Moreover, GM1-mediated TrkC autophosphorylation was blocked by TrkC-IgG (but not TrkB-IgG) receptor bodies, further suggesting that GM1 activates TrkC by inducing the release of neurotrophin-3.	G(M1) Ganglioside	132-135	neurotrophic receptor tyrosine kinase 3	Homo sapiens	63-67
12388556-10	2002	Moreover, GM1-mediated TrkC autophosphorylation was blocked by TrkC-IgG (but not TrkB-IgG) receptor bodies, further suggesting that GM1 activates TrkC by inducing the release of neurotrophin-3.	G(M1) Ganglioside	132-135	neurotrophic receptor tyrosine kinase 3	Homo sapiens	63-67
12388556-10	2002	Moreover, GM1-mediated TrkC autophosphorylation was blocked by TrkC-IgG (but not TrkB-IgG) receptor bodies, further suggesting that GM1 activates TrkC by inducing the release of neurotrophin-3.	G(M1) Ganglioside	132-135	neurotrophin 3	Homo sapiens	178-192
12388556-12	2002	GM1 induced neurotrophin-3 (but not brain-derived neurotrophic factor or nerve growth factor) release.	G(M1) Ganglioside	0-3	neurotrophin 3	Homo sapiens	12-26
12445726-6	2002	Cholera toxin B subunit (CTB) is a specific ligand for ganglioside GM1 and can be used for the detection of GM1 containing DRM.	G(M1) Ganglioside	55-70	phosphate cytidylyltransferase 1B, choline	Homo sapiens	25-28
12445726-6	2002	Cholera toxin B subunit (CTB) is a specific ligand for ganglioside GM1 and can be used for the detection of GM1 containing DRM.	G(M1) Ganglioside	67-70	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-23
12445726-6	2002	Cholera toxin B subunit (CTB) is a specific ligand for ganglioside GM1 and can be used for the detection of GM1 containing DRM.	G(M1) Ganglioside	67-70	phosphate cytidylyltransferase 1B, choline	Homo sapiens	25-28
12374211-3	2002	Only for GM1-induced process, molecular mechanisms of signal transduction coincide with the ones for CD95 and TNFalpha: the participation of both the main initiation caspases 8, 1, and 4, and caspases 3 and 9 as well, has been shown.	G(M1) Ganglioside	9-12	Fas (TNF receptor superfamily member 6)	Mus musculus	101-105
12376557-5	2002	Clusters of ErbB2 colocalized with lipid rafts identified by the GM1-binding B subunit of cholera toxin.	G(M1) Ganglioside	65-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	12-17
12376557-6	2002	Pixel-by-pixel analysis of fluorescence resonance energy transfer between labeled antibodies indicated that the homoassociation (homodimerization) of ErbB2 was proportional to the local density of ErbB2 and inversely proportional to that of ErbB3 and of the raft-specific lipid GM1.	G(M1) Ganglioside	278-281	erb-b2 receptor tyrosine kinase 2	Homo sapiens	150-155
12136426-9	2002	Preventative effects of IL-2 transduction of the liver against liver metastasis were lost after depletion of NK cells by treatment with anti-asialo GM1 antibodies.	G(M1) Ganglioside	148-151	interleukin 2	Rattus norvegicus	24-28
12239168-8	2002	The ganglioside GM1, a marker of rafts, was augmented in TCR-stimulated but not IL-7-stimulated T lymphocytes, and disruption of rafts inhibited gp120-induced signaling.	G(M1) Ganglioside	16-19	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	57-60
12374211-1	2002	Ganglioside-induced apoptosis in the cells of IL-2-dependent cytotoxic murine cell line CTLL-2 was shown to be caspase dependent: GM1-, GM2-, and GD3-induced suppression of cell proliferation was cancelled by a general caspase inhibitor Z-VAD-FMK.	G(M1) Ganglioside	130-133	interleukin 2	Mus musculus	46-50
12374211-1	2002	Ganglioside-induced apoptosis in the cells of IL-2-dependent cytotoxic murine cell line CTLL-2 was shown to be caspase dependent: GM1-, GM2-, and GD3-induced suppression of cell proliferation was cancelled by a general caspase inhibitor Z-VAD-FMK.	G(M1) Ganglioside	130-133	caspase 1	Mus musculus	111-118
12374211-3	2002	Only for GM1-induced process, molecular mechanisms of signal transduction coincide with the ones for CD95 and TNFalpha: the participation of both the main initiation caspases 8, 1, and 4, and caspases 3 and 9 as well, has been shown.	G(M1) Ganglioside	9-12	tumor necrosis factor	Mus musculus	110-118
12374211-1	2002	Ganglioside-induced apoptosis in the cells of IL-2-dependent cytotoxic murine cell line CTLL-2 was shown to be caspase dependent: GM1-, GM2-, and GD3-induced suppression of cell proliferation was cancelled by a general caspase inhibitor Z-VAD-FMK.	G(M1) Ganglioside	130-133	caspase 1	Mus musculus	219-226
12374211-3	2002	Only for GM1-induced process, molecular mechanisms of signal transduction coincide with the ones for CD95 and TNFalpha: the participation of both the main initiation caspases 8, 1, and 4, and caspases 3 and 9 as well, has been shown.	G(M1) Ganglioside	9-12	caspase 8	Mus musculus	166-208
12036855-7	2002	Moreover, cells stained with fluorescently labeled MIP-1 beta extensively colocalized with the GM1 lipid raft marker while using anti-CCR5 antibodies; most of CCR5 on these cells only partially colocalized with GM1, suggesting that active ligand binding facilitates receptor association with lipid rafts or that raft association promotes a higher affinity conformation of CCR5.	G(M1) Ganglioside	95-98	C-C motif chemokine ligand 4	Homo sapiens	51-61
12036855-7	2002	Moreover, cells stained with fluorescently labeled MIP-1 beta extensively colocalized with the GM1 lipid raft marker while using anti-CCR5 antibodies; most of CCR5 on these cells only partially colocalized with GM1, suggesting that active ligand binding facilitates receptor association with lipid rafts or that raft association promotes a higher affinity conformation of CCR5.	G(M1) Ganglioside	211-214	C-C motif chemokine ligand 4	Homo sapiens	51-61
12070301-4	2002	In addition, overexpression of wild-type Rab7 or Rab9 (but not Rab11) in Niemann-Pick type C (NP-C) lipid storage disease fibroblasts resulted in correction of lipid trafficking defects, including restoration of Golgi targeting of fluorescent lactosylceramide and endogenous GM(1) ganglioside, and a dramatic reduction in intracellular cholesterol stores.	G(M1) Ganglioside	275-292	RAB7B, member RAS oncogene family	Homo sapiens	41-45
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	G(M1) Ganglioside	248-251	amyloid beta precursor protein	Homo sapiens	119-124
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	G(M1) Ganglioside	248-251	amyloid beta precursor protein	Homo sapiens	153-158
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	G(M1) Ganglioside	248-251	amyloid beta precursor protein	Homo sapiens	153-158
12070301-4	2002	In addition, overexpression of wild-type Rab7 or Rab9 (but not Rab11) in Niemann-Pick type C (NP-C) lipid storage disease fibroblasts resulted in correction of lipid trafficking defects, including restoration of Golgi targeting of fluorescent lactosylceramide and endogenous GM(1) ganglioside, and a dramatic reduction in intracellular cholesterol stores.	G(M1) Ganglioside	275-292	RAB9A, member RAS oncogene family	Homo sapiens	49-53
12021313-4	2002	Here, we show that after T cell stimulation, CTLA-4 coclusters with the TCR and the lipid raft ganglioside GM1 within the IS.	G(M1) Ganglioside	107-110	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	45-51
11886870-7	2002	We also show by immunofluorescence that in unstimulated cells the EGF receptor is localized in non-caveolar lipid rafts containing the ganglioside GM1 and that patching of these rafts by cholera toxin B-chain causes co-patching of EGF receptors.	G(M1) Ganglioside	147-150	epidermal growth factor	Homo sapiens	66-69
12015984-5	2002	This switch-like transition for movement can be shifted to lower PtdIns(4,5)P2 concentrations by the addition of cholesterol/sphingomyelin or GM1 ganglioside/cholera toxin, conditions that produce raft-like behavior of Unc104 bound to lipid bilayers.	G(M1) Ganglioside	142-145	kinesin family member 1A	Homo sapiens	219-225
11967288-7	2002	Biochemical fractionation and confocal imaging of HIV-1 receptor distribution in live cells demonstrated that CD4, CCR5, and CXCR4 colocalized with raft-resident markers, ganglioside GM1, and glycosylphosphatidylinositol-anchored CD48.	G(M1) Ganglioside	183-186	CD4 molecule	Homo sapiens	110-113
12065629-0	2002	GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain.	G(M1) Ganglioside	0-15	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	58-61
12065629-0	2002	GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain.	G(M1) Ganglioside	0-15	Eph receptor B1	Rattus norvegicus	66-69
12065629-1	2002	We investigated the ability of GM1 to induce phosphorylation of the tyrosine kinase receptor for neurotrophins, Trk, in rat brain, and activation of possible down-stream signaling cascades.	G(M1) Ganglioside	31-34	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	112-115
12065629-2	2002	GM1 increased phosphorylated Trk (pTrk) in slices of striatum, hippocampus and frontal cortex in a concentration- and time-dependent manner, and enhanced the activity of Trk kinase resulting in receptor autophosphorylation.	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	29-32
12065629-2	2002	GM1 increased phosphorylated Trk (pTrk) in slices of striatum, hippocampus and frontal cortex in a concentration- and time-dependent manner, and enhanced the activity of Trk kinase resulting in receptor autophosphorylation.	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	35-38
12065629-3	2002	The ability of GM1 to induce pTrk was shared by other gangliosides, and was blocked by the selective Trk kinase inhibitors K252a and AG879.	G(M1) Ganglioside	15-18	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	30-33
12065629-4	2002	GM1 induced phosphorylation of TrkA > TrkC > TrkB in a region-specific distribution.	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	31-35
12065629-4	2002	GM1 induced phosphorylation of TrkA > TrkC > TrkB in a region-specific distribution.	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 3	Rattus norvegicus	41-45
12065629-4	2002	GM1 induced phosphorylation of TrkA > TrkC > TrkB in a region-specific distribution.	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	51-55
12065629-5	2002	Adding GM1 to brain slices activated extracellular-regulated protein kinases (Erks) in all three brain regions studied.	G(M1) Ganglioside	7-10	mitogen activated protein kinase 3	Rattus norvegicus	78-82
12065629-6	2002	In striatum, GM1 elicited activation of Erk2 > Erk1 in a time-and concentration-dependent manner.	G(M1) Ganglioside	13-16	mitogen activated protein kinase 1	Rattus norvegicus	40-44
12065629-6	2002	In striatum, GM1 elicited activation of Erk2 > Erk1 in a time-and concentration-dependent manner.	G(M1) Ganglioside	13-16	mitogen activated protein kinase 3	Rattus norvegicus	50-54
12065629-7	2002	The GM1 effect on Erk2 was mimicked by other gangliosides, and was blocked by the Trk kinase inhibitors K252a and AG879.	G(M1) Ganglioside	4-7	mitogen activated protein kinase 1	Rattus norvegicus	18-22
12065629-7	2002	The GM1 effect on Erk2 was mimicked by other gangliosides, and was blocked by the Trk kinase inhibitors K252a and AG879.	G(M1) Ganglioside	4-7	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	82-85
12065629-9	2002	Intracerebroventricular administration of GM1 induced a transient phosphorylation of TrkA and Erk1/2 in the striatum and hippocampus complementing the in situ studies.	G(M1) Ganglioside	42-45	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	85-89
12065629-9	2002	Intracerebroventricular administration of GM1 induced a transient phosphorylation of TrkA and Erk1/2 in the striatum and hippocampus complementing the in situ studies.	G(M1) Ganglioside	42-45	mitogen activated protein kinase 3	Rattus norvegicus	94-100
12065629-10	2002	These observations support a role for GM1 in modulating Trk and Erk phosphorylation and activity in brain.	G(M1) Ganglioside	38-41	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	56-59
12065629-10	2002	These observations support a role for GM1 in modulating Trk and Erk phosphorylation and activity in brain.	G(M1) Ganglioside	38-41	Eph receptor B1	Rattus norvegicus	64-67
12829403-2	2002	GM1 ganglioside has been shown to activate Trk, the tyrosine kinase receptor implicated in the neuroprotective properties of the neurotrophins.	G(M1) Ganglioside	0-15	neurotrophic receptor tyrosine kinase 1	Homo sapiens	43-46
11937572-7	2002	CXCR4 surface expression, on the other hand, only partially colocalized with GM1.	G(M1) Ganglioside	77-80	C-X-C motif chemokine receptor 4	Homo sapiens	0-5
11856346-6	2002	Association of CD25 with rafts was also confirmed by its colocalization with GM-1 ganglioside.	G(M1) Ganglioside	77-93	interleukin 2 receptor subunit alpha	Homo sapiens	15-19
11917140-0	2002	Cell membrane GM1 ganglioside is a functional coreceptor for fibroblast growth factor 2.	G(M1) Ganglioside	14-29	fibroblast growth factor 2	Cricetulus griseus	61-87
11917140-5	2002	Conversely, overloading of endothelial GM 7373 cell membranes with exogenous GM1 causes a 10-fold increase of the mitogenic potency of FGF2.	G(M1) Ganglioside	77-80	fibroblast growth factor 2	Bos taurus	135-139
11917140-6	2002	125I-FGF2 binds to cell membrane GM1 (K(d) = 3 nM) in complex ganglioside/heparan sulfate-deficient Chinese hamster ovary (CHO)-K1-pgsA745 cell mutants that were overloaded with exogenous GM1.	G(M1) Ganglioside	33-36	fibroblast growth factor 2	Bos taurus	5-9
11917140-6	2002	125I-FGF2 binds to cell membrane GM1 (K(d) = 3 nM) in complex ganglioside/heparan sulfate-deficient Chinese hamster ovary (CHO)-K1-pgsA745 cell mutants that were overloaded with exogenous GM1.	G(M1) Ganglioside	188-191	fibroblast growth factor 2	Bos taurus	5-9
11917140-7	2002	Moreover, FGF2 competes with FITC-CTB for the binding to cell membrane GM1 in different CHO cell lines independently of their capacity to express heparan sulfate proteoglycans.	G(M1) Ganglioside	71-74	fibroblast growth factor 2	Cricetulus griseus	10-14
11917140-9	2002	Finally, GM1-overloading confers to FGF receptor 1-transfected, complex ganglioside-deficient CHO-K1 cell mutants the capacity to proliferate when stimulated by FGF2.	G(M1) Ganglioside	9-12	fibroblast growth factor 2	Cricetulus griseus	161-165
11917140-12	2002	In conclusion, cell membrane GM1 binds FGF2 and is required for the mitogenic activity of the growth factor.	G(M1) Ganglioside	29-32	fibroblast growth factor 2	Cricetulus griseus	39-43
11952645-1	2002	The inhibitory action of gangliosides GT1B, GD1A, GM3 and GM1 on cell proliferation and epidermal growth factor receptor (EGFR) phosphorylation was determined in the N-myc amplified human neuroblastoma cell line NBL-W.	G(M1) Ganglioside	58-61	Epidermal growth factor receptor	Drosophila melanogaster	88-120
11934394-2	2002	Then the activity of PKC began to decline and even turned to be inhibited with the further increase of GM(1) content.	G(M1) Ganglioside	103-108	proline rich transmembrane protein 2	Homo sapiens	21-24
11934394-4	2002	Besides, the liposomes containing about 2 mol% GM(1) provided a more hydrophobic environment for PKC than the liposomes containing less or more GM(1) which was indicated in the Acrylodan experiments.	G(M1) Ganglioside	47-52	proline rich transmembrane protein 2	Homo sapiens	97-100
11884440-5	2002	However, cross-linking of GM1 through cholera toxin B-subunit (CTB) causes an enrichment of beta(1) integrins in microdomain fractions, suggesting that cross-linking lipid microdomains causes a reorganization of molecular associations.	G(M1) Ganglioside	26-29	phosphate cytidylyltransferase 1B, choline	Homo sapiens	63-66
11999340-3	2002	In T cells activated by crosslinking the GPI-linked protein Thy-1 or by crosslinking the ganglioside GM1, reggie-1/flotillin-2 co-localizes with the T cell receptor.	G(M1) Ganglioside	101-104	flotillin 2	Homo sapiens	115-126
11999340-6	2002	On non-activated mature B cell Raji cell line we found reggie-1/flotillin-2 are exclusively in the detergent (TX100) insoluble membrane fractions that are staining positive for the raft marker GM1.	G(M1) Ganglioside	193-196	flotillin 2	Homo sapiens	64-75
11827518-1	2002	Cholera toxin entry into mammalian cells is mediated by binding of the pentameric B subunit (CTB) to ganglioside GM(1) in the cell membrane.	G(M1) Ganglioside	101-118	phosphate cytidylyltransferase 1B, choline	Homo sapiens	93-96
11827518-5	2002	From equilibrium measurements, we determined an equilibrium binding constant for a single subunit of FITC-CTB binding monovalently to GM(1) presented in bilayers of approximately 8 x 10(7) M(-1) while that for binding to soluble GM(1)-pentasaccharide was found to be approximately 4 x 10(6) M(-1).	G(M1) Ganglioside	134-139	phosphate cytidylyltransferase 1B, choline	Homo sapiens	106-109
11870920-7	2002	The resulting IL5 variant, [(87)PVEGRV(92)]GM1, was able to bind to IL5Ralpha in biosensor assays, to elicit TF-1 cell proliferation and to induce STAT5 phosphorylation in TF-1 cells.	G(M1) Ganglioside	43-46	interleukin 5	Homo sapiens	14-17
11799176-6	2002	In stringent support of these data, CD4 colocalized with patches of cholera toxin bound to the raft-associated sphingoglycolipid GM1, whereas CXCR4 did not.	G(M1) Ganglioside	129-132	CD4 molecule	Homo sapiens	36-39
11785946-7	2002	Confocal microscopic results and FCET measurements show that MHC-I and ICAM-1 are components of G(M1)-ganglioside containing lipid-rafts and also support an increase in the size of these lipid-rafts upon INF-gamma treatment.	G(M1) Ganglioside	96-113	intercellular adhesion molecule 1	Homo sapiens	71-77
12142032-9	2002	TCR clustering led only to a partial colocalization of TCRs with raft GSL, ganglioside GM1, and a complete colocalization of CP with TCRs.	G(M1) Ganglioside	75-90	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	0-3
11870920-7	2002	The resulting IL5 variant, [(87)PVEGRV(92)]GM1, was able to bind to IL5Ralpha in biosensor assays, to elicit TF-1 cell proliferation and to induce STAT5 phosphorylation in TF-1 cells.	G(M1) Ganglioside	43-46	interleukin 5 receptor subunit alpha	Homo sapiens	68-77
11870920-7	2002	The resulting IL5 variant, [(87)PVEGRV(92)]GM1, was able to bind to IL5Ralpha in biosensor assays, to elicit TF-1 cell proliferation and to induce STAT5 phosphorylation in TF-1 cells.	G(M1) Ganglioside	43-46	signal transducer and activator of transcription 5A	Homo sapiens	147-152
11675488-1	2001	We investigated intracellular trafficking of GM1 ganglioside in Niemann-Pick C1 (NPC1)-deficient Chinese hamster ovary cells [NPC1(-) cells] by using cholera toxin (CT) as a probe.	G(M1) Ganglioside	45-60	NPC intracellular cholesterol transporter 1	Cricetulus griseus	81-85
11711493-6	2001	GM1 and GM2 (50 micromol/L) stimulate phosphorylation of extracellular signal-regulated kinases (ERKs) 1 and 2 and phosphorylation of the c-Jun N-terminal kinase (JNK), with a maximum at 15 minutes, but they do not have an effect on the phosphorylation of p38 mitogen-activated protein kinase (MAPK).	G(M1) Ganglioside	0-3	rolled	Drosophila melanogaster	57-110
11711493-6	2001	GM1 and GM2 (50 micromol/L) stimulate phosphorylation of extracellular signal-regulated kinases (ERKs) 1 and 2 and phosphorylation of the c-Jun N-terminal kinase (JNK), with a maximum at 15 minutes, but they do not have an effect on the phosphorylation of p38 mitogen-activated protein kinase (MAPK).	G(M1) Ganglioside	0-3	basket	Drosophila melanogaster	138-161
11711493-6	2001	GM1 and GM2 (50 micromol/L) stimulate phosphorylation of extracellular signal-regulated kinases (ERKs) 1 and 2 and phosphorylation of the c-Jun N-terminal kinase (JNK), with a maximum at 15 minutes, but they do not have an effect on the phosphorylation of p38 mitogen-activated protein kinase (MAPK).	G(M1) Ganglioside	0-3	basket	Drosophila melanogaster	163-166
11711493-6	2001	GM1 and GM2 (50 micromol/L) stimulate phosphorylation of extracellular signal-regulated kinases (ERKs) 1 and 2 and phosphorylation of the c-Jun N-terminal kinase (JNK), with a maximum at 15 minutes, but they do not have an effect on the phosphorylation of p38 mitogen-activated protein kinase (MAPK).	G(M1) Ganglioside	0-3	p38a MAP kinase	Drosophila melanogaster	256-292
11711493-12	2001	We may conclude that GM1 and GM2 stimulate ERK1/2 via a pertussis toxin-sensitive G(i)-coupled receptor through a Raf-1 kinase-independent pathway.	G(M1) Ganglioside	21-24	rolled	Drosophila melanogaster	43-49
11711493-12	2001	We may conclude that GM1 and GM2 stimulate ERK1/2 via a pertussis toxin-sensitive G(i)-coupled receptor through a Raf-1 kinase-independent pathway.	G(M1) Ganglioside	21-24	Raf oncogene	Drosophila melanogaster	114-119
11711493-13	2001	Moreover, the GM1- and GM2-induced VSMC growth is ERK1/2 dependent.	G(M1) Ganglioside	14-17	rolled	Drosophila melanogaster	50-56
11606627-3	2001	This is possible now thanks to the recent cloning of plasma membrane ganglioside sialidase (PMGS), the enzyme responsible for the localized hydrolysis of oligosialogangliosides into GM1.	G(M1) Ganglioside	182-185	neuraminidase 3	Homo sapiens	69-90
11675488-2	2001	Both the holotoxin and the B subunit (CTB) accumulated in GM1-enriched intracellular vesicles of NPC1(-) cells.	G(M1) Ganglioside	58-61	phosphate cytidylyltransferase 1B, choline	Homo sapiens	38-41
11675488-2	2001	Both the holotoxin and the B subunit (CTB) accumulated in GM1-enriched intracellular vesicles of NPC1(-) cells.	G(M1) Ganglioside	58-61	NPC intracellular cholesterol transporter 1	Homo sapiens	97-101
11675488-10	2001	These results suggest that transport of CT/GM1 complexes from the early endosome to the plasma membrane depends on the function of NPC1, whereas transport to the Golgi apparatus/endoplasmic reticulum does not.	G(M1) Ganglioside	43-46	NPC intracellular cholesterol transporter 1	Homo sapiens	131-135
11520799-4	2001	It is demonstrated that antibody- or ligand-mediated immobilization of components of lipid rafts, glycosyl-phosphatidyl-inositol-anchored proteins, and the GM1 ganglioside, respectively, inhibit IL-2-induced proliferation in T cells.	G(M1) Ganglioside	156-171	interleukin 2	Homo sapiens	195-199
11598189-4	2001	Jurkat cells, after cross-linking of Thy-1 or GM1 (with the use of cholera toxin), exhibit substantial colocalization of reggie-1 and -2 with Thy-1, GM1, the T-cell receptor complex and fyn.	G(M1) Ganglioside	46-49	Thy-1 cell surface antigen	Homo sapiens	142-147
11451961-1	2001	The cell density-dependent growth inhibition of human SK-N-MC neuroblastoma cells is initiated by increased ganglioside sialidase activity leading to elevated cell surface presentation of ganglioside GM1, a ligand of galectin-1.	G(M1) Ganglioside	200-203	hedgehog acyltransferase	Homo sapiens	54-58
11451961-1	2001	The cell density-dependent growth inhibition of human SK-N-MC neuroblastoma cells is initiated by increased ganglioside sialidase activity leading to elevated cell surface presentation of ganglioside GM1, a ligand of galectin-1.	G(M1) Ganglioside	200-203	galectin 1	Homo sapiens	217-227
11549733-4	2001	The main components of lipids released after the addition of Abeta were cholesterol, phospholipids, and monosialoganglioside (GM1).	G(M1) Ganglioside	126-129	amyloid beta precursor protein	Homo sapiens	61-66
11516650-8	2001	Second, in the presence of Nef, viral envelopes contain more ganglioside (GM1), which is a major component of lipid rafts.	G(M1) Ganglioside	74-77	S100 calcium binding protein B	Homo sapiens	27-30
11342534-1	2001	GM1 ganglioside-bound amyloid beta-protein (GM1/Abeta), found in brains exhibiting early pathological changes of Alzheimer"s disease (AD) including diffuse plaques, has been suggested to be involved in the initiation of amyloid fibril formation in vivo by acting as a seed.	G(M1) Ganglioside	0-15	amyloid beta precursor protein	Homo sapiens	48-53
11342534-2	2001	To elucidate the molecular mechanism underlying GM1/Abeta formation, the effects of lipid composition on the binding of Abeta to GM1-containing lipid bilayers were examined in detail using fluorescent dye-labeled human Abeta-(1-40).	G(M1) Ganglioside	129-132	amyloid beta precursor protein	Homo sapiens	120-125
11342534-3	2001	Increases in not only GM1 but also cholesterol contents in the lipid bilayers facilitated the binding of Abeta to the membranes by altering the binding capacity but not the binding affinity.	G(M1) Ganglioside	22-25	amyloid beta precursor protein	Homo sapiens	105-110
11342534-5	2001	Excimer formation of fluorescent dye-labeled GM1 suggested that Abeta recognizes a GM1 "cluster" in membranes, the formation of which is facilitated by cholesterol.	G(M1) Ganglioside	45-48	amyloid beta precursor protein	Homo sapiens	64-69
11342534-5	2001	Excimer formation of fluorescent dye-labeled GM1 suggested that Abeta recognizes a GM1 "cluster" in membranes, the formation of which is facilitated by cholesterol.	G(M1) Ganglioside	83-86	amyloid beta precursor protein	Homo sapiens	64-69
11298323-4	2001	CD55, a glycosylphosphatidylinositol-anchored protein, a ganglioside GM1 and Lyn, a Src family tyrosine kinase, were also located in these complexes.	G(M1) Ganglioside	57-72	CD55 molecule (Cromer blood group)	Homo sapiens	0-4
11350083-5	2001	The results show that the ganglioside sialidase codistributes with the raft markers ganglioside GM1, flotillin, src family kinases, and glycosylphosphatidylinositol-anchored proteins in a fraction containing about 2% of cellular protein.	G(M1) Ganglioside	84-99	neuraminidase 3	Homo sapiens	26-47
11504386-6	2001	Guinea pigs fed on CM and GM1 developed high titres (> 1500) of anti-beta-lg IgG1, with an important cross reactivity between goat and cow beta-lg.	G(M1) Ganglioside	26-29	beta-lactoglobulin	Bos taurus	72-79
11282993-0	2001	Evidence for a role of ganglioside GM1 in antigen presentation: binding enhances presentation of Escherichia coli enterotoxin B subunit (EtxB) to CD4(+) T cells.	G(M1) Ganglioside	35-38	CD4 molecule	Homo sapiens	146-149
11282993-4	2001	Thus, GM1-mediated presentation of EtxB by B cells and CD11c(+) dendritic cells (DC) significantly enhanced the proliferation and cytokine expression of EtxB-specific CD4(+) T cells.	G(M1) Ganglioside	6-9	CD4 molecule	Homo sapiens	167-170
11368158-2	2001	A beta 1-42, A beta 1-40, A beta 40-1, and A beta 1-38, but not A beta 25-35, bound to GM1 ganglioside in the following rank order: A beta 1-42 > A beta 40-1 > A beta 1-40 > A beta 1-38.	G(M1) Ganglioside	87-102	amyloid beta precursor protein	Homo sapiens	0-6
11368158-2	2001	A beta 1-42, A beta 1-40, A beta 40-1, and A beta 1-38, but not A beta 25-35, bound to GM1 ganglioside in the following rank order: A beta 1-42 > A beta 40-1 > A beta 1-40 > A beta 1-38.	G(M1) Ganglioside	87-102	amyloid beta precursor protein	Homo sapiens	13-19
11368158-2	2001	A beta 1-42, A beta 1-40, A beta 40-1, and A beta 1-38, but not A beta 25-35, bound to GM1 ganglioside in the following rank order: A beta 1-42 > A beta 40-1 > A beta 1-40 > A beta 1-38.	G(M1) Ganglioside	87-102	amyloid beta precursor protein	Homo sapiens	13-19
11368158-4	2001	Aged derivatives of A beta were found to have higher affinity to GM1 ganglioside than fresh or soluble derivatives.	G(M1) Ganglioside	65-80	amyloid beta precursor protein	Homo sapiens	20-26
11101310-3	2000	IL-5 has previously been re-engineered into the monomeric, one-domain GM1 form by introducing an eight-residue linker between the third and fourth helices.	G(M1) Ganglioside	70-73	interleukin 5	Homo sapiens	0-4
11113129-4	2001	Second, CD9 and alpha(3) integrin colocalized with ganglioside GM1 as seen by double staining of fixed cells.	G(M1) Ganglioside	51-66	CD9 molecule	Homo sapiens	8-11
11474253-10	2001	Injecting the anti-thy 1,2 (CD90), anti-CD4 or anti-CD8 monoclonal antibody into conventional BALB/c mice resulted in the resumption of in vivo growth of Meth-A/IL-17 cells, but injecting the anti-asialo GM1 antibody did not.	G(M1) Ganglioside	204-207	thymus cell antigen 1, theta	Mus musculus	19-26
11474253-10	2001	Injecting the anti-thy 1,2 (CD90), anti-CD4 or anti-CD8 monoclonal antibody into conventional BALB/c mice resulted in the resumption of in vivo growth of Meth-A/IL-17 cells, but injecting the anti-asialo GM1 antibody did not.	G(M1) Ganglioside	204-207	thymus cell antigen 1, theta	Mus musculus	28-32
11120819-5	2000	The same set of stimuli also induced relocation of endogenous PKCtheta and IKKs to a GM1 ganglioside-enriched, detergent-insoluble membrane compartment in primary T cells.	G(M1) Ganglioside	85-100	protein kinase C theta	Homo sapiens	62-70
11101310-7	2000	On the basis of this result, two mutants of GM1 were constructed with the intent to retain receptor alpha-chain binding while modifying receptor activation epitopes.	G(M1) Ganglioside	44-47	Fc gamma receptor and transporter	Homo sapiens	100-111
10981968-2	2000	We have described autoreactive T cells responsive to GM1 ganglioside presented by CD1b.	G(M1) Ganglioside	53-68	CD1b molecule	Homo sapiens	82-86
11154849-0	2000	Promotion of neurite outgrowth by protein kinase inhibitors and ganglioside GM1 in neuroblastoma cells involves MAP kinase ERK1/2.	G(M1) Ganglioside	64-79	rolled	Drosophila melanogaster	123-129
11154849-6	2000	Pretreatment of serum-depleted Neuro-2a cultures with GM1 or BIM enhanced ERK1/2 phosphorylation when the serum level was restored to 10%.	G(M1) Ganglioside	54-57	mitogen-activated protein kinase 3	Mus musculus	74-80
11074098-7	2000	These results show that CTB-saporin can eliminate motoneurons as well as sympathetic preganglionic neurons, indicate that protocols for the injection of tracer-toxins should be optimized to ensure maximum neuronal death and support our contention that CTB-saporin should kill any central neuron that expresses GM1 ganglioside, the membrane component to which CTB binds.	G(M1) Ganglioside	310-325	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	24-27
11074098-7	2000	These results show that CTB-saporin can eliminate motoneurons as well as sympathetic preganglionic neurons, indicate that protocols for the injection of tracer-toxins should be optimized to ensure maximum neuronal death and support our contention that CTB-saporin should kill any central neuron that expresses GM1 ganglioside, the membrane component to which CTB binds.	G(M1) Ganglioside	310-325	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	252-255
11074098-7	2000	These results show that CTB-saporin can eliminate motoneurons as well as sympathetic preganglionic neurons, indicate that protocols for the injection of tracer-toxins should be optimized to ensure maximum neuronal death and support our contention that CTB-saporin should kill any central neuron that expresses GM1 ganglioside, the membrane component to which CTB binds.	G(M1) Ganglioside	310-325	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	252-255
10942779-9	2000	The enzymatic hydrolysis of the ganglioside GM1 is catalyzed by beta-galactosidase, a water-soluble acid exohydrolase.	G(M1) Ganglioside	44-47	galactosidase beta 1	Homo sapiens	64-82
10942779-11	2000	In this study we demonstrate that an activator protein is required for the enzymatic degradation of membrane-bound ganglioside GM1 and that both SAP-B and the GM2 activator protein significantly enhance the degradation of the ganglioside GM1 by acid beta-galactosidase in a liposomal, detergent-free assay system.	G(M1) Ganglioside	127-130	galactosidase beta 1	Homo sapiens	250-268
10942779-11	2000	In this study we demonstrate that an activator protein is required for the enzymatic degradation of membrane-bound ganglioside GM1 and that both SAP-B and the GM2 activator protein significantly enhance the degradation of the ganglioside GM1 by acid beta-galactosidase in a liposomal, detergent-free assay system.	G(M1) Ganglioside	238-241	galactosidase beta 1	Homo sapiens	250-268
10949532-4	2000	Statistical analysis showed that anti-GD3 antibodies were less frequent in patients with GBS or MFS from whom C. jejuni had been isolated than were other antiganglioside antibodies, such as anti-GM1 antibodies.	G(M1) Ganglioside	195-198	GRDX	Homo sapiens	38-41
10981968-7	2000	Binding to CD1b is a highly reversible process and other ceramide-containing glycosphingolipids displace GM1.	G(M1) Ganglioside	105-108	CD1b molecule	Homo sapiens	11-15
11201795-1	2000	Our previous studies have shown that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factor receptor, Trk, which is an essential factor for the normal development and differentiation of neuronal cells by forming a complex with Trk.	G(M1) Ganglioside	63-78	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	285-288
10773410-10	2000	Immunohistochemical observation revealed the presence of asialo GM1(+) cells among the KB/IL-2 cells in tumors transplanted into nude mice.	G(M1) Ganglioside	64-67	interleukin 2	Mus musculus	90-94
10801129-7	2000	In the plasma membrane Cbp is exclusively localized in the GM1 ganglioside-enriched detergent-insoluble membrane domain, which is important in receptor-mediated signalling.	G(M1) Ganglioside	59-74	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	23-26
10757351-1	2000	Mutations in the lysosomal acid beta-galactosidase (EC 3.2.1.23) underlie two different disorders: GM1 gangliosidosis, which involves the nervous system and visceral organs to varying extents, and Morquio"s syndrome type B (Morquio B disease), which is a skeletal-connective tissue disease without any CNS symptoms.	G(M1) Ganglioside	99-102	galactosidase beta 1	Homo sapiens	32-50
10757351-2	2000	This article shows that transduction of human GM1 gangliosidosis fibroblasts with retrovirus vectors encoding the human acid beta-galactosidase cDNA leads to complete correction of the enzymatic deficiency.	G(M1) Ganglioside	46-49	galactosidase beta 1	Homo sapiens	125-143
11201795-1	2000	Our previous studies have shown that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factor receptor, Trk, which is an essential factor for the normal development and differentiation of neuronal cells by forming a complex with Trk.	G(M1) Ganglioside	63-78	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	116-158
10878369-12	2000	Finally, depletion of NK cells by anti-asialo GM1 Ab mostly abrogated the residual production of IFN-gamma in IL-12p40-/- mice.	G(M1) Ganglioside	46-49	interferon gamma	Mus musculus	97-106
10878369-12	2000	Finally, depletion of NK cells by anti-asialo GM1 Ab mostly abrogated the residual production of IFN-gamma in IL-12p40-/- mice.	G(M1) Ganglioside	46-49	interleukin 12b	Mus musculus	110-118
10887996-3	2000	The activities of lysosomal acid beta-galactosidase in its leucocytes and liver were less than 2 per cent of the control levels, and the compound accumulated in the brain was identified as GM1 ganglioside.	G(M1) Ganglioside	189-204	galactosidase beta 1	Canis lupus familiaris	33-51
10754294-7	2000	Immunodepletion with anti-asialo-GM1 or anti-CD4 during C3L5-CK beta 11 vaccination significantly reduced CK beta-11 antitumor activity compared with control and anti-CD8-treated groups.	G(M1) Ganglioside	33-36	creatine kinase, brain	Mus musculus	106-113
10699320-4	2000	Western blot analysis with antiserum to cholera toxin B subunit (CTB) indicated that rLTB had cross-reactivity to native CTB and its GM1 binding ability was almost the same as that of the CTB.	G(M1) Ganglioside	133-136	lymphotoxin beta	Rattus norvegicus	85-89
10751590-0	2000	Characterization of beta-galactosidase in leukocytes and fibroblasts of GM1 gangliosidosis heterozygotes compared to normal subjects.	G(M1) Ganglioside	72-75	galactosidase beta 1	Homo sapiens	20-38
10751590-1	2000	OBJECTIVES: Characterization of beta-galactosidase in leukocytes and fibroblasts of heterozygotes for GM1 type I.	G(M1) Ganglioside	102-105	galactosidase beta 1	Homo sapiens	32-50
11201795-1	2000	Our previous studies have shown that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factor receptor, Trk, which is an essential factor for the normal development and differentiation of neuronal cells by forming a complex with Trk.	G(M1) Ganglioside	63-78	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	160-163
11201795-1	2000	Our previous studies have shown that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factor receptor, Trk, which is an essential factor for the normal development and differentiation of neuronal cells by forming a complex with Trk.	G(M1) Ganglioside	75-78	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	116-158
11201795-1	2000	Our previous studies have shown that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factor receptor, Trk, which is an essential factor for the normal development and differentiation of neuronal cells by forming a complex with Trk.	G(M1) Ganglioside	75-78	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	160-163
11201795-1	2000	Our previous studies have shown that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factor receptor, Trk, which is an essential factor for the normal development and differentiation of neuronal cells by forming a complex with Trk.	G(M1) Ganglioside	75-78	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	285-288
11201795-3	2000	In order to study the effect of the glycosylation of Trk on the formation of GM1-Trk complex and subcellular distribution of this protein, we generated PC12 cells stably overexpressing Trk (PCtrk).	G(M1) Ganglioside	77-80	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	53-56
11201795-3	2000	In order to study the effect of the glycosylation of Trk on the formation of GM1-Trk complex and subcellular distribution of this protein, we generated PC12 cells stably overexpressing Trk (PCtrk).	G(M1) Ganglioside	77-80	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	81-84
11201795-3	2000	In order to study the effect of the glycosylation of Trk on the formation of GM1-Trk complex and subcellular distribution of this protein, we generated PC12 cells stably overexpressing Trk (PCtrk).	G(M1) Ganglioside	77-80	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	81-84
11201795-7	2000	Moreover, these unglycosylated Trk proteins lose their ability to form a complex with GM1, although GM1 is present in the same high density fractions.	G(M1) Ganglioside	86-89	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	31-34
11201795-7	2000	Moreover, these unglycosylated Trk proteins lose their ability to form a complex with GM1, although GM1 is present in the same high density fractions.	G(M1) Ganglioside	100-103	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	31-34
11201795-8	2000	These data strongly suggest that spatial segregation of GM1 from the Trk protein by the inhibition of the glycosylation of Trk might be an important molecular mechanism for the unresponsiveness to NGF.	G(M1) Ganglioside	56-59	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	123-126
11201795-9	2000	Moreover, the binding site of GM1 in the Trk protein might act as an important determinant for the normal trafficking of the Trk protein within the cells.	G(M1) Ganglioside	30-33	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	41-44
11201795-9	2000	Moreover, the binding site of GM1 in the Trk protein might act as an important determinant for the normal trafficking of the Trk protein within the cells.	G(M1) Ganglioside	30-33	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	125-128
10562533-3	1999	CCR5 associates with membrane raft microdomains, and its polarization parallels redistribution of raft molecules, including the raft-associated ganglioside GM1, glycosylphosphatidylinositol-anchored green fluorescent protein and ephrinB1, to the leading edge.	G(M1) Ganglioside	156-159	C-C motif chemokine receptor 5	Homo sapiens	0-4
10608819-3	1999	The alpha-series gangliosides displayed enhanced potency for MAG- and SMP-mediated cell adhesion (GQ1balpha > GT1aalpha, GD1alpha > GT1b, GD1a >> GM1 (nonbinding)), whereas sialoadhesin-mediated adhesion was comparable with alpha-series and non-alpha-series gangliosides.	G(M1) Ganglioside	158-161	myelin associated glycoprotein	Homo sapiens	61-64
10574921-8	1999	However, GM1 and GD1a induced expression of COX-2 but had little effect on NO and TNF-alpha release.	G(M1) Ganglioside	9-12	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	44-49
10652309-3	2000	While both CTB and LTB bind to the GM1 ganglioside, LTB also binds to N-acetyllactosamine-terminated glycoconjugates.	G(M1) Ganglioside	35-50	phosphate cytidylyltransferase 1B, choline	Homo sapiens	11-14
10652309-3	2000	While both CTB and LTB bind to the GM1 ganglioside, LTB also binds to N-acetyllactosamine-terminated glycoconjugates.	G(M1) Ganglioside	35-50	lymphotoxin beta	Homo sapiens	19-22
10963436-2	2000	Upon incubation with gangliosides for 24 h, their effect resulting in appearance of apoptotic cells, falls in a series GM2 > GM3 > GM1 > GD1a > GD1b > GT1b.	G(M1) Ganglioside	137-140	cytochrome b5 domain containing 2	Mus musculus	119-122
10963436-2	2000	Upon incubation with gangliosides for 24 h, their effect resulting in appearance of apoptotic cells, falls in a series GM2 > GM3 > GM1 > GD1a > GD1b > GT1b.	G(M1) Ganglioside	137-140	granulocyte macrophage antigen 3	Mus musculus	128-131
10963436-3	2000	In the presence of rIL-2, apoptosis induced by GM1 is suppressed, whereas that induced by GM2 is enhanced (the effect of intracellular agent C2-Cer is independent of this cytokine).	G(M1) Ganglioside	47-50	interleukin 2	Rattus norvegicus	19-24
10600840-5	1999	The CTB subunit binds preferentially to GM1 in caveolae, and N-ethylmaleimide treatment drastically inhibits the intracellular accumulation of CTB.	G(M1) Ganglioside	40-43	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	4-7
10600840-5	1999	The CTB subunit binds preferentially to GM1 in caveolae, and N-ethylmaleimide treatment drastically inhibits the intracellular accumulation of CTB.	G(M1) Ganglioside	40-43	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	143-146
10477786-0	1999	High levels of GM(1)-ganglioside and GM(1)-ganglioside beta-galactosidase in the parotid gland: a new model for secretory mechanisms of the parotid gland.	G(M1) Ganglioside	37-54	galactosidase, beta 1	Mus musculus	55-73
10697503-3	1999	We examined if GM1 affects interactions between PDGFR-beta and specific proteins involved in PDGFR-mediated signaling.	G(M1) Ganglioside	15-18	platelet derived growth factor receptor beta	Homo sapiens	48-58
10697503-3	1999	We examined if GM1 affects interactions between PDGFR-beta and specific proteins involved in PDGFR-mediated signaling.	G(M1) Ganglioside	15-18	platelet derived growth factor receptor beta	Homo sapiens	48-53
10697503-6	1999	GM1 decreased these associations in parallel with decreased tyrosine phosphorylation of PDGFR.	G(M1) Ganglioside	0-3	platelet derived growth factor receptor beta	Homo sapiens	88-93
10697503-9	1999	GM1 probably inhibits PDGF-induced signaling proteins with PDGFR-beta by inhibiting phosphorylation of specific tyrosines on the receptor which bind to SH2-domains on signaling proteins.	G(M1) Ganglioside	0-3	platelet derived growth factor receptor beta	Homo sapiens	59-69
10547418-1	1999	Taking advantage of the ability of pentameric cholera toxin B subunit (CTB) to bind selectively to GM1, we developed recently a CTB-mediated GM1 lipid vesicle delivery system to target drugs and proteins to mucosal tissues [1].	G(M1) Ganglioside	99-102	phosphate cytidylyltransferase 1B, choline	Homo sapiens	71-74
10547418-1	1999	Taking advantage of the ability of pentameric cholera toxin B subunit (CTB) to bind selectively to GM1, we developed recently a CTB-mediated GM1 lipid vesicle delivery system to target drugs and proteins to mucosal tissues [1].	G(M1) Ganglioside	99-102	phosphate cytidylyltransferase 1B, choline	Homo sapiens	128-131
10547418-1	1999	Taking advantage of the ability of pentameric cholera toxin B subunit (CTB) to bind selectively to GM1, we developed recently a CTB-mediated GM1 lipid vesicle delivery system to target drugs and proteins to mucosal tissues [1].	G(M1) Ganglioside	141-144	phosphate cytidylyltransferase 1B, choline	Homo sapiens	71-74
10547418-1	1999	Taking advantage of the ability of pentameric cholera toxin B subunit (CTB) to bind selectively to GM1, we developed recently a CTB-mediated GM1 lipid vesicle delivery system to target drugs and proteins to mucosal tissues [1].	G(M1) Ganglioside	141-144	phosphate cytidylyltransferase 1B, choline	Homo sapiens	128-131
10547418-3	1999	Intranasal administration of a recombinant HIV envelope protein formulated in CTB-associated GM1 lipid vesicles enhanced mucosal IgA antibody responses detected in the nasal and gut tissues, compared to that of control animals immunized with antigen formulated in GM1-free vesicles with CTB or formulated in alum-associated vesicles with CTB.	G(M1) Ganglioside	93-96	phosphate cytidylyltransferase 1B, choline	Homo sapiens	78-81
10547418-3	1999	Intranasal administration of a recombinant HIV envelope protein formulated in CTB-associated GM1 lipid vesicles enhanced mucosal IgA antibody responses detected in the nasal and gut tissues, compared to that of control animals immunized with antigen formulated in GM1-free vesicles with CTB or formulated in alum-associated vesicles with CTB.	G(M1) Ganglioside	93-96	phosphate cytidylyltransferase 1B, choline	Homo sapiens	287-290
10547418-3	1999	Intranasal administration of a recombinant HIV envelope protein formulated in CTB-associated GM1 lipid vesicles enhanced mucosal IgA antibody responses detected in the nasal and gut tissues, compared to that of control animals immunized with antigen formulated in GM1-free vesicles with CTB or formulated in alum-associated vesicles with CTB.	G(M1) Ganglioside	93-96	phosphate cytidylyltransferase 1B, choline	Homo sapiens	287-290
10547418-3	1999	Intranasal administration of a recombinant HIV envelope protein formulated in CTB-associated GM1 lipid vesicles enhanced mucosal IgA antibody responses detected in the nasal and gut tissues, compared to that of control animals immunized with antigen formulated in GM1-free vesicles with CTB or formulated in alum-associated vesicles with CTB.	G(M1) Ganglioside	264-267	phosphate cytidylyltransferase 1B, choline	Homo sapiens	78-81
10547418-4	1999	We found a nearly 2- to 3-fold enhancement in IgA antibody titers detected both in nasal and gut tissues using the CTB-GM1 lipid vesicle delivery system, compared to using the GM1-free lipid vesicle system.	G(M1) Ganglioside	119-122	phosphate cytidylyltransferase 1B, choline	Homo sapiens	115-118
10547418-6	1999	IgG isotype analysis indicates that CTB in GM1 vesicle delivery system enhanced both IgG1 and IgG2a while CTB in alum formulation enhanced only IgG1.	G(M1) Ganglioside	43-46	phosphate cytidylyltransferase 1B, choline	Homo sapiens	36-39
10547418-7	1999	However, IgA and IgG antibody responses against CTB were similar for GM1 vesicles regardless of whether HIV-env was present in the vaccine formulation.	G(M1) Ganglioside	69-72	phosphate cytidylyltransferase 1B, choline	Homo sapiens	48-51
10547418-8	1999	Collectively, these data indicate that delivery of HIV-env to mucosal epithelial cells with CTB-associated GM1 lipid vesicles enhanced mucosal and systemic immune responses against the HIV-envelope protein.	G(M1) Ganglioside	107-110	phosphate cytidylyltransferase 1B, choline	Homo sapiens	92-95
10547418-9	1999	It is possible that both the CTB-mediated targeted delivery of antigen-loaded GM1 lipid vesicles and mucosal adjuvanticity of CTB may be involved in enhancing the immune responses.	G(M1) Ganglioside	78-81	phosphate cytidylyltransferase 1B, choline	Homo sapiens	29-32
10571006-0	1999	Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure-function studies of lysosomal beta-galactosidase and the non-lysosomal beta-galactosidase-like protein.	G(M1) Ganglioside	19-22	galactosidase beta 1	Homo sapiens	107-125
10029078-6	1999	PC-3M-IFN-beta cells produced small tumors (3-5 mm in diameter) in nude mice treated with anti-asialo GM1 antibodies and in severe combined immunodeficient/Beige mice.	G(M1) Ganglioside	102-105	interferon beta 1, fibroblast	Mus musculus	6-14
10477274-5	1999	We found that in cell clones expressing moderate levels of activity, GalNAc-T immunoreactivity behaved as the trans-Golgi network (TGN) marker mannose-6-P receptor (M6PR) both in BFA-treated and untreated cells, and that BFA completely blocked the synthesis of GM2, GM1 and GD1a.	G(M1) Ganglioside	266-269	Polypeptide N-acetylgalactosaminyltransferase 35A	Drosophila melanogaster	69-77
10477274-6	1999	On the other hand, in cell clones expressing high levels of activity and treated with BFA, most GalNAc-T immunoreactivity redistributed to the endoplasmic reticulum, as did the medial-Golgi marker mannosidase II, and the synthesis of GM2, GM1 and GD1a was not completely blocked.	G(M1) Ganglioside	239-242	Polypeptide N-acetylgalactosaminyltransferase 35A	Drosophila melanogaster	96-104
10498246-8	1999	Immunodepletion of activated natural killer cells with anti-asialo-GM1 blocked C3L5-Flt3L- and C3L5 plus soluble Flt3L-mediated antitumor activity.	G(M1) Ganglioside	67-70	FMS-like tyrosine kinase 3 ligand	Mus musculus	84-89
10498246-8	1999	Immunodepletion of activated natural killer cells with anti-asialo-GM1 blocked C3L5-Flt3L- and C3L5 plus soluble Flt3L-mediated antitumor activity.	G(M1) Ganglioside	67-70	FMS-like tyrosine kinase 3 ligand	Mus musculus	113-118
10318836-5	1999	In hematopoietic cells, these low density Triton-insoluble (LDTI) microdomains (also called caveolae-related domains) are dramatically enriched in signaling molecules, such as cell surface receptors (CD4 and CD55), Src family tyrosine kinases (Lyn, Lck, Hck, and Fyn), heterotrimeric G proteins, and gangliosides (GM1 and GM3).	G(M1) Ganglioside	314-317	CD4 molecule	Homo sapiens	200-203
10318836-5	1999	In hematopoietic cells, these low density Triton-insoluble (LDTI) microdomains (also called caveolae-related domains) are dramatically enriched in signaling molecules, such as cell surface receptors (CD4 and CD55), Src family tyrosine kinases (Lyn, Lck, Hck, and Fyn), heterotrimeric G proteins, and gangliosides (GM1 and GM3).	G(M1) Ganglioside	314-317	CD55 molecule (Cromer blood group)	Homo sapiens	208-212
10337924-1	1999	Previously, we reported that IgA anti-GM1 antibody is more closely associated with preceding Campylobacter jejuni enteritis in Guillain-Barre syndrome (GBS) than are IgG and IgM antibodies.	G(M1) Ganglioside	38-41	CD79a molecule	Homo sapiens	29-32
10337924-3	1999	In this study, serum IgA antibodies against GM1, GM1b, and GD1a, and GalNAc-GD1a were examined in 152 GBS patients.	G(M1) Ganglioside	44-47	CD79a molecule	Homo sapiens	21-24
10337924-9	1999	This may support the previous report that IgA isotype anti-GM1 antibodies are more closely associated with poor outcome than are the IgG or IgM isotypes.	G(M1) Ganglioside	59-62	CD79a molecule	Homo sapiens	42-45
10029590-2	1999	Here, we report that neutralization of natural killer (NK) cell function with antibodies to either asialo GM1 or NK 1.1 reversed IL-12 inhibition of basic fibroblast growth factor (bFGF)-induced angiogenesis in athymic mice.	G(M1) Ganglioside	106-109	fibroblast growth factor 2	Mus musculus	149-179
10029590-2	1999	Here, we report that neutralization of natural killer (NK) cell function with antibodies to either asialo GM1 or NK 1.1 reversed IL-12 inhibition of basic fibroblast growth factor (bFGF)-induced angiogenesis in athymic mice.	G(M1) Ganglioside	106-109	fibroblast growth factor 2	Mus musculus	181-185
10399959-0	1999	Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells.	G(M1) Ganglioside	45-48	fibroblast growth factor 2	Homo sapiens	84-114
10399959-3	1999	Pre-treatment of bovine aortic endothelial cells (BAEC) with GM1 or GM2 (5-20 microM) inhibited basic-fibroblast-growth-factor (bFGF)-induced mitogenesis, but GM3 (0.1-20 microM) acted synergistically, increasing proliferation above that of bFGF alone (p < 0.05).	G(M1) Ganglioside	61-64	fibroblast growth factor 2	Bos taurus	96-126
10399959-3	1999	Pre-treatment of bovine aortic endothelial cells (BAEC) with GM1 or GM2 (5-20 microM) inhibited basic-fibroblast-growth-factor (bFGF)-induced mitogenesis, but GM3 (0.1-20 microM) acted synergistically, increasing proliferation above that of bFGF alone (p < 0.05).	G(M1) Ganglioside	61-64	fibroblast growth factor 2	Bos taurus	128-132
10399959-3	1999	Pre-treatment of bovine aortic endothelial cells (BAEC) with GM1 or GM2 (5-20 microM) inhibited basic-fibroblast-growth-factor (bFGF)-induced mitogenesis, but GM3 (0.1-20 microM) acted synergistically, increasing proliferation above that of bFGF alone (p < 0.05).	G(M1) Ganglioside	61-64	fibroblast growth factor 2	Bos taurus	241-245
10399959-5	1999	We further show that GM1 and to a lesser extent GM2 modify bFGF binding to its receptor and inhibit the associated mitogenic signal-transduction pathway of protein-tyrosine phosphorylation of 40 to 120 kDa, PLCgamma1, MAP kinase and protein-kinase-C activation.	G(M1) Ganglioside	21-24	fibroblast growth factor 2	Homo sapiens	59-63
10399959-5	1999	We further show that GM1 and to a lesser extent GM2 modify bFGF binding to its receptor and inhibit the associated mitogenic signal-transduction pathway of protein-tyrosine phosphorylation of 40 to 120 kDa, PLCgamma1, MAP kinase and protein-kinase-C activation.	G(M1) Ganglioside	21-24	phospholipase C gamma 1	Homo sapiens	207-216
10399959-7	1999	The observed differential modulation of bFGF-induced mitogenesis by GM1, GM2 and GM3 was at concentrations routinely occurring in the serum of cancer patients.	G(M1) Ganglioside	68-71	fibroblast growth factor 2	Homo sapiens	40-44
10393343-1	1999	In a previous paper we showed that the B-pentamer of cholera toxin (CT-B) binds with reduced binding strength to different C(1) derivatives of N-acetylneuraminic acid (NeuAc) of the natural receptor ganglioside, GM1.	G(M1) Ganglioside	212-215	phosphate cytidylyltransferase 1B, choline	Homo sapiens	68-72
9949160-6	1999	(3) 32D, 32D GM1, and 32D G1 cell lines with mast cell, granulo-macrophagic, and granulocytic phenotype, respectively, expressed all the PKC isoforms investigated, but showed distinct responses to growth factor readdition.	G(M1) Ganglioside	13-16	protein kinase C epsilon	Homo sapiens	137-140
9972872-0	1999	Myelin basic protein and myelin basic protein peptides induce the proliferation of Schwann cells via ganglioside GM1 and the FGF receptor.	G(M1) Ganglioside	101-116	myelin basic protein	Homo sapiens	0-20
9950679-4	1999	Also, gangliosides protect native FGF-2 from trypsin digestion at micromolar concentrations, the order of relative potency being GT1b > GD1b > GM1 = GM2 = sulfatide > GM3 = galactosyl-ceramide, whereas asialo-GM1, neuraminic acid, and N-acetylneuramin-lactose were ineffective.	G(M1) Ganglioside	149-152	fibroblast growth factor 2	Homo sapiens	34-39
9950679-10	1999	Accordingly, GT1b,GD1b, GM1, and GM2, but not GM3 and asialo-GM1, prevent the binding of 125I-FGF-2 to a soluble, recombinant form of extracellular FGFR-1.	G(M1) Ganglioside	24-27	fibroblast growth factor 2	Homo sapiens	94-99
9950679-10	1999	Accordingly, GT1b,GD1b, GM1, and GM2, but not GM3 and asialo-GM1, prevent the binding of 125I-FGF-2 to a soluble, recombinant form of extracellular FGFR-1.	G(M1) Ganglioside	24-27	fibroblast growth factor receptor 1	Homo sapiens	148-154
9950679-11	1999	Conversely, the soluble receptor and free heparin inhibit the interaction of fluorochrome-labeled GM1 to immobilized FGF-2.	G(M1) Ganglioside	98-101	fibroblast growth factor 2	Homo sapiens	117-122
10208581-3	1999	Treatment with GM1 ganglioside (30 mg/kg i.p., daily for 30 days) restored, in part, the neuropeptide deficits in the ventral horns, but not in the dorsal horns.	G(M1) Ganglioside	15-30	pyroglutamylated RFamide peptide	Rattus norvegicus	89-101
9972868-2	1999	Recently it has been shown that GM1 binds tightly with membrane-bound amyloid beta protein (A beta) and prevents its conversion from a helical to a beta-sheet structure.	G(M1) Ganglioside	32-35	amyloid beta precursor protein	Homo sapiens	92-98
9972868-2	1999	Recently it has been shown that GM1 binds tightly with membrane-bound amyloid beta protein (A beta) and prevents its conversion from a helical to a beta-sheet structure.	G(M1) Ganglioside	32-35	amyloid beta precursor protein	Homo sapiens	146-152
9972868-3	1999	To examine the potential physiological consequences of this binding, we studied the effect of GM1 on A beta-stimulated release of proinflammatory cytokines, such as interleukin (IL)-1beta, IL-6 and TNF-alpha, using the human monocytic cell line, THP-1, as a model system.	G(M1) Ganglioside	94-97	amyloid beta precursor protein	Homo sapiens	101-107
9972872-0	1999	Myelin basic protein and myelin basic protein peptides induce the proliferation of Schwann cells via ganglioside GM1 and the FGF receptor.	G(M1) Ganglioside	101-116	myelin basic protein	Homo sapiens	25-45
9972868-5	1999	However, treatment of A beta-activated THP-1 cells with GM1 and several other complex gangliosides, but not hematosides and neutral glycosphingolipids such as asialo-GM1 (GA1), lactosylceramide, and globoside, significantly decreased the cytokine release.	G(M1) Ganglioside	56-59	amyloid beta precursor protein	Homo sapiens	22-28
9972868-5	1999	However, treatment of A beta-activated THP-1 cells with GM1 and several other complex gangliosides, but not hematosides and neutral glycosphingolipids such as asialo-GM1 (GA1), lactosylceramide, and globoside, significantly decreased the cytokine release.	G(M1) Ganglioside	56-59	GLI family zinc finger 2	Homo sapiens	39-44
9972872-6	1999	The binding of MBP to ganglioside GM1 and the ability of MBP peptides containing homology to the B subunit of cholera toxin (which binds ganglioside GM1) to compete for the binding of a mitogenic peptide (MBP(1-44)) to SC, identified ganglioside GM1 as a second SC receptor.	G(M1) Ganglioside	22-37	myelin basic protein	Homo sapiens	15-18
9972868-7	1999	A direct interaction between GM1 and A beta was demonstrated using the surface plasmon resonance technique.	G(M1) Ganglioside	29-32	amyloid beta precursor protein	Homo sapiens	37-43
9972872-6	1999	The binding of MBP to ganglioside GM1 and the ability of MBP peptides containing homology to the B subunit of cholera toxin (which binds ganglioside GM1) to compete for the binding of a mitogenic peptide (MBP(1-44)) to SC, identified ganglioside GM1 as a second SC receptor.	G(M1) Ganglioside	34-37	myelin basic protein	Homo sapiens	15-18
9972868-8	1999	We found that GM1 ganglioside exhibited higher affinity for A beta 1-40 than GA1, suggesting that the sialic acid moiety of GM1 is necessary for its interaction with A beta.	G(M1) Ganglioside	14-29	amyloid beta precursor protein	Homo sapiens	60-66
9972868-8	1999	We found that GM1 ganglioside exhibited higher affinity for A beta 1-40 than GA1, suggesting that the sialic acid moiety of GM1 is necessary for its interaction with A beta.	G(M1) Ganglioside	14-29	amyloid beta precursor protein	Homo sapiens	166-172
9972872-6	1999	The binding of MBP to ganglioside GM1 and the ability of MBP peptides containing homology to the B subunit of cholera toxin (which binds ganglioside GM1) to compete for the binding of a mitogenic peptide (MBP(1-44)) to SC, identified ganglioside GM1 as a second SC receptor.	G(M1) Ganglioside	149-152	myelin basic protein	Homo sapiens	57-60
9972868-8	1999	We found that GM1 ganglioside exhibited higher affinity for A beta 1-40 than GA1, suggesting that the sialic acid moiety of GM1 is necessary for its interaction with A beta.	G(M1) Ganglioside	14-17	amyloid beta precursor protein	Homo sapiens	60-66
9972868-8	1999	We found that GM1 ganglioside exhibited higher affinity for A beta 1-40 than GA1, suggesting that the sialic acid moiety of GM1 is necessary for its interaction with A beta.	G(M1) Ganglioside	14-17	amyloid beta precursor protein	Homo sapiens	166-172
9972872-6	1999	The binding of MBP to ganglioside GM1 and the ability of MBP peptides containing homology to the B subunit of cholera toxin (which binds ganglioside GM1) to compete for the binding of a mitogenic peptide (MBP(1-44)) to SC, identified ganglioside GM1 as a second SC receptor.	G(M1) Ganglioside	149-152	myelin basic protein	Homo sapiens	57-60
9972868-9	1999	We conclude that the inhibitory effect of GM1 on A beta-induced cytokine release may reflect pre-existing abnormalities in membrane transport at the stage of amyloid formation and that GM1 may induce conformational changes in A beta, resulting in diminished fibrillogenesis and prevention of the inflammatory response of neuronal cells in Alzheimer"s disease.	G(M1) Ganglioside	42-45	amyloid beta precursor protein	Homo sapiens	49-55
9972872-7	1999	Based on these results, we conclude that MBP(1-44) and MBP(152-167) associate with ganglioside GM1 and the bFGF receptor respectively to stimulate SC mitosis.	G(M1) Ganglioside	95-98	myelin basic protein	Homo sapiens	41-44
9972868-9	1999	We conclude that the inhibitory effect of GM1 on A beta-induced cytokine release may reflect pre-existing abnormalities in membrane transport at the stage of amyloid formation and that GM1 may induce conformational changes in A beta, resulting in diminished fibrillogenesis and prevention of the inflammatory response of neuronal cells in Alzheimer"s disease.	G(M1) Ganglioside	185-188	amyloid beta precursor protein	Homo sapiens	226-232
9972872-7	1999	Based on these results, we conclude that MBP(1-44) and MBP(152-167) associate with ganglioside GM1 and the bFGF receptor respectively to stimulate SC mitosis.	G(M1) Ganglioside	95-98	myelin basic protein	Homo sapiens	55-58
9860269-0	1998	Effect of the mono- and tetra-sialogangliosides, GM1 and GQ1b, on long-term potentiation in the CA1 hippocampal neurons of the guinea pig.	G(M1) Ganglioside	49-52	carbonic anhydrase 1	Cavia porcellus	96-99
10512048-6	1999	We have also studied the interaction of the recombinant IL-4 with fluorescent (anthrylvinyl-labelled) gangliosides GM1 and GM3 and lactosylceramide incorporated into liposomes.	G(M1) Ganglioside	115-118	interleukin 4	Homo sapiens	56-60
10512048-8	1999	The K(d) values for the lymphokine complexes with gangliosides support the conclusion based on the kinetic analysis that IL-4 has a higher affinity for GM3 (K(d) = 5 nM) than for GM1 (K(d) = 0.28 microM).	G(M1) Ganglioside	179-182	interleukin 4	Homo sapiens	121-125
9860269-6	1998	Based on these findings, we conclude that GM1 and GQ1b exert positive modulatory effects on the induction of LTP in hippocampal CA1 neurons and suggest that GM1 and GQ1b may participate in the induction of LTP as donors of Ca2+ ions.	G(M1) Ganglioside	42-45	carbonic anhydrase 1	Cavia porcellus	128-131
9860269-6	1998	Based on these findings, we conclude that GM1 and GQ1b exert positive modulatory effects on the induction of LTP in hippocampal CA1 neurons and suggest that GM1 and GQ1b may participate in the induction of LTP as donors of Ca2+ ions.	G(M1) Ganglioside	42-45	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	223-226
9860269-6	1998	Based on these findings, we conclude that GM1 and GQ1b exert positive modulatory effects on the induction of LTP in hippocampal CA1 neurons and suggest that GM1 and GQ1b may participate in the induction of LTP as donors of Ca2+ ions.	G(M1) Ganglioside	157-160	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	223-226
9813248-3	1998	We have shown that concurrent intraperitoneal administration of GM1 with a low and otherwise unprotective intracerebroventricular dose of nerve growth factor, can also prevent the loss of these fimbria fornix axotomised cholinergic neurons, where GM1 alone does not have this effect.	G(M1) Ganglioside	64-67	nerve growth factor	Homo sapiens	138-157
10066091-8	1998	On the other hand, in rats receiving anti-asialo GM1 antibody, 9L cells transfected with M-CSF gene developed into tumors, though at a slower rate than control 9L cells.	G(M1) Ganglioside	49-52	colony stimulating factor 1	Rattus norvegicus	89-94
9826367-7	1998	The cells were confirmed to be NK cells by abrogation of YAC-1 cell cytotoxicity by treatment in vitro and in vivo with anti-asialo-GM1.	G(M1) Ganglioside	132-135	ADP-ribosyltransferase 1	Mus musculus	57-62
9826367-8	1998	The early IFN-gamma response could also be depleted by treatment with anti-asialo-GM1, indicating that NK cells were responsible for the production of this cytokine.	G(M1) Ganglioside	82-85	interferon gamma	Mus musculus	10-19
9813248-4	1998	This study further confirms the neuroprotective actions of GM1 and suggests that it may interact to potentiate the effect of nerve growth factor on these axotomised septal cholinergic neurons.	G(M1) Ganglioside	59-62	nerve growth factor	Homo sapiens	125-144
9849885-0	1998	Influence of endogenous GM1 ganglioside on TrkB activity, in cultured neurons.	G(M1) Ganglioside	24-39	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	43-47
9849885-3	1998	After treatment, the amount of GM1 associated to receptor and TrkB phosphorylation decreased by about 40%.	G(M1) Ganglioside	31-34	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	62-66
9849885-4	1998	The amount of associated GM1 decreased by about 33% also after concomitant treatment with phorbol ester and brain-derived neurotrophic factor, but in this case the neurotrophin was unable to enhance receptor tyrosine phosphorylation.	G(M1) Ganglioside	25-28	brain-derived neurotrophic factor	Rattus norvegicus	108-141
9849885-5	1998	These results for the first time suggest that changes in the amount of endogenous GM1 in the environment of TrkB can modulate receptor activity, and offer new clues for a better understanding of physiological and pathological events of the nervous system.	G(M1) Ganglioside	82-85	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	108-112
9748278-2	1998	Our previous studies have shown that cholera toxin B subunit, which specifically binds to the cell surface ganglioside GM1, and GM1 itself can enhance the action of nerve growth factor (NGF) in responsive cells by enhancing the NGF-induced autophosphorylation of the high affinity NGF receptor, Trk.	G(M1) Ganglioside	107-122	nerve growth factor	Rattus norvegicus	165-184
9847018-1	1998	Cats with inherited GM1 gangliosidosis (GM1 mutant cats) have premature thymic involution characterized by decreased total thymocytes primarily affecting the CD4+ CD8+ subpopulation.	G(M1) Ganglioside	20-23	CD4 molecule	Felis catus	158-161
9847018-10	1998	Although, CD4 expression on both feline thymocyte and lymph node cell membranes was abruptly decreased after introducing exogenous GM1, enhanced apoptotic death was observed only in thymocytes, not in lymph node cells at the same GM1 concentration.	G(M1) Ganglioside	131-134	CD4 molecule	Felis catus	10-13
9761744-7	1998	Unlike that released by Triton X-100, only part of the Thy-1 molecules released by MBCD was buoyant in density gradients and co-isolated with GM1.	G(M1) Ganglioside	142-145	Thy-1 cell surface antigen	Homo sapiens	55-60
9748278-2	1998	Our previous studies have shown that cholera toxin B subunit, which specifically binds to the cell surface ganglioside GM1, and GM1 itself can enhance the action of nerve growth factor (NGF) in responsive cells by enhancing the NGF-induced autophosphorylation of the high affinity NGF receptor, Trk.	G(M1) Ganglioside	107-122	nerve growth factor	Rattus norvegicus	186-189
9748278-2	1998	Our previous studies have shown that cholera toxin B subunit, which specifically binds to the cell surface ganglioside GM1, and GM1 itself can enhance the action of nerve growth factor (NGF) in responsive cells by enhancing the NGF-induced autophosphorylation of the high affinity NGF receptor, Trk.	G(M1) Ganglioside	107-122	nerve growth factor	Rattus norvegicus	228-231
9748278-2	1998	Our previous studies have shown that cholera toxin B subunit, which specifically binds to the cell surface ganglioside GM1, and GM1 itself can enhance the action of nerve growth factor (NGF) in responsive cells by enhancing the NGF-induced autophosphorylation of the high affinity NGF receptor, Trk.	G(M1) Ganglioside	107-122	nerve growth factor	Rattus norvegicus	228-231
9748278-2	1998	Our previous studies have shown that cholera toxin B subunit, which specifically binds to the cell surface ganglioside GM1, and GM1 itself can enhance the action of nerve growth factor (NGF) in responsive cells by enhancing the NGF-induced autophosphorylation of the high affinity NGF receptor, Trk.	G(M1) Ganglioside	119-122	nerve growth factor	Rattus norvegicus	165-184
9748278-2	1998	Our previous studies have shown that cholera toxin B subunit, which specifically binds to the cell surface ganglioside GM1, and GM1 itself can enhance the action of nerve growth factor (NGF) in responsive cells by enhancing the NGF-induced autophosphorylation of the high affinity NGF receptor, Trk.	G(M1) Ganglioside	119-122	nerve growth factor	Rattus norvegicus	186-189
9748278-2	1998	Our previous studies have shown that cholera toxin B subunit, which specifically binds to the cell surface ganglioside GM1, and GM1 itself can enhance the action of nerve growth factor (NGF) in responsive cells by enhancing the NGF-induced autophosphorylation of the high affinity NGF receptor, Trk.	G(M1) Ganglioside	119-122	nerve growth factor	Rattus norvegicus	228-231
9748278-2	1998	Our previous studies have shown that cholera toxin B subunit, which specifically binds to the cell surface ganglioside GM1, and GM1 itself can enhance the action of nerve growth factor (NGF) in responsive cells by enhancing the NGF-induced autophosphorylation of the high affinity NGF receptor, Trk.	G(M1) Ganglioside	119-122	nerve growth factor	Rattus norvegicus	228-231
9748278-9	1998	The present results and our previous observations clearly demonstrate that Trk requires endogenous gangliosides, especially GM1, for its normal function in mediating the neurotrophic activity of NGF at least in PC12 cells.	G(M1) Ganglioside	124-127	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	75-78
9748278-9	1998	The present results and our previous observations clearly demonstrate that Trk requires endogenous gangliosides, especially GM1, for its normal function in mediating the neurotrophic activity of NGF at least in PC12 cells.	G(M1) Ganglioside	124-127	nerve growth factor	Rattus norvegicus	195-198
9710006-5	1998	There was, however, a tendency for an increased frequency of HLA-DRB1*0803 in the C. jejuni + GM1 + GBS group, when compared with controls.	G(M1) Ganglioside	94-97	major histocompatibility complex, class II, DR beta 1	Homo sapiens	61-69
9735345-4	1998	In the presence of glycolipid GM1-ganglioside, SP-A"s globular headgroup regions appeared enlarged and only small non-fibrous clusters were observed.	G(M1) Ganglioside	30-45	pulmonary surfactant-associated protein A	Bos taurus	47-51
9788349-4	1998	Transgenic potato tubers produced 0.1% of total soluble protein as the pentameric CTB-insulin fusion, which retained GM1-ganglioside binding affinity and native antigenicity of both CTB and insulin.	G(M1) Ganglioside	117-132	insulin	Homo sapiens	86-93
9682003-4	1998	Orthovanadate treatment drastically inhibited the down-regulation of CD4 induced by GM1 but had no effect on down-modulation of CD4 induced by GD1a.	G(M1) Ganglioside	84-87	CD4 molecule	Homo sapiens	69-72
9682003-0	1998	The down-modulation of CD4 induced by the GM1 ganglioside is regulated by phosphatases and kinases: evidence from enzyme inhibitors and anti-CD45 antibodies.	G(M1) Ganglioside	42-57	CD4 molecule	Homo sapiens	23-26
9682003-5	1998	Exposure to monoclonal antibodies (mAbs) against CD45 and CD45RA but not against CD45RO abrogated the down-modulation of CD4 by GM1.	G(M1) Ganglioside	128-131	protein tyrosine phosphatase receptor type C	Homo sapiens	49-53
9682003-0	1998	The down-modulation of CD4 induced by the GM1 ganglioside is regulated by phosphatases and kinases: evidence from enzyme inhibitors and anti-CD45 antibodies.	G(M1) Ganglioside	42-57	protein tyrosine phosphatase receptor type C	Homo sapiens	141-145
9682003-5	1998	Exposure to monoclonal antibodies (mAbs) against CD45 and CD45RA but not against CD45RO abrogated the down-modulation of CD4 by GM1.	G(M1) Ganglioside	128-131	protein tyrosine phosphatase receptor type C	Homo sapiens	58-62
9682003-2	1998	Exposure of PBL either to genistein or to H7 practically abolished the down-modulation of CD4 induced by GM1 and diminished their susceptibility to CD4+ down-modulation by exposure to GD1a.	G(M1) Ganglioside	105-108	CD4 molecule	Homo sapiens	90-93
9682003-5	1998	Exposure to monoclonal antibodies (mAbs) against CD45 and CD45RA but not against CD45RO abrogated the down-modulation of CD4 by GM1.	G(M1) Ganglioside	128-131	CD4 molecule	Homo sapiens	49-52
9682003-11	1998	The present study indicates that the capacity of GM1 to down-modulate CD4 depended on the CD45 and particularly CD45RA molecules, while other gangliosides may utilize different cell surface structures to down-modulate the expression of CD4.	G(M1) Ganglioside	49-52	CD4 molecule	Homo sapiens	70-73
9682003-11	1998	The present study indicates that the capacity of GM1 to down-modulate CD4 depended on the CD45 and particularly CD45RA molecules, while other gangliosides may utilize different cell surface structures to down-modulate the expression of CD4.	G(M1) Ganglioside	49-52	protein tyrosine phosphatase receptor type C	Homo sapiens	90-94
9682003-11	1998	The present study indicates that the capacity of GM1 to down-modulate CD4 depended on the CD45 and particularly CD45RA molecules, while other gangliosides may utilize different cell surface structures to down-modulate the expression of CD4.	G(M1) Ganglioside	49-52	CD4 molecule	Homo sapiens	90-93
9712367-7	1998	Exogenous gangliosides (bovine brain gangliosides and purified GM1) inhibited IDO expression throughout the first 24 h after IFN-gamma treatment by mechanisms that did not involve effects on Ca2+ channels.	G(M1) Ganglioside	63-66	indoleamine 2,3-dioxygenase 1	Homo sapiens	78-81
9767427-3	1998	Both the ADP-ribosylation activity of LTA and GM1 binding of LTB have been proposed to be involved in immune stimulation.	G(M1) Ganglioside	46-49	lymphotoxin B	Mus musculus	61-64
9767427-6	1998	With respect to the immunogenicity of LT and LTB, we found that GM1-binding activity is essential for effective induction of anti-LTB antibodies.	G(M1) Ganglioside	64-67	lymphotoxin B	Mus musculus	45-48
9767427-6	1998	With respect to the immunogenicity of LT and LTB, we found that GM1-binding activity is essential for effective induction of anti-LTB antibodies.	G(M1) Ganglioside	64-67	lymphotoxin B	Mus musculus	130-133
9767427-8	1998	Whereas adjuvanticity of LTB was found to be directly related to GM1-binding activity, adjuvanticity of LT was found to be independent of GM1-binding affinity.	G(M1) Ganglioside	65-68	lymphotoxin B	Mus musculus	25-28
9712367-7	1998	Exogenous gangliosides (bovine brain gangliosides and purified GM1) inhibited IDO expression throughout the first 24 h after IFN-gamma treatment by mechanisms that did not involve effects on Ca2+ channels.	G(M1) Ganglioside	63-66	interferon gamma	Bos taurus	125-134
9668343-7	1998	GM3 inhibits both the epidermal growth factor receptor and basic fibroblast factor receptor; several gangliosides except GM3 inhibit the platelet-derived growth-factor receptor; GM1 enhances nerve growth-factor-stimulated activation of TrkA; insulin receptor is inhibited to varying degrees by several gangliosides, but 2-->3 sialosylparagloboside is most effective.	G(M1) Ganglioside	178-181	neurotrophic receptor tyrosine kinase 1	Homo sapiens	236-240
9668343-7	1998	GM3 inhibits both the epidermal growth factor receptor and basic fibroblast factor receptor; several gangliosides except GM3 inhibit the platelet-derived growth-factor receptor; GM1 enhances nerve growth-factor-stimulated activation of TrkA; insulin receptor is inhibited to varying degrees by several gangliosides, but 2-->3 sialosylparagloboside is most effective.	G(M1) Ganglioside	178-181	insulin receptor	Homo sapiens	242-258
9668377-0	1998	Effect of GM1 on TrkA dimerization.	G(M1) Ganglioside	10-13	neurotrophic receptor tyrosine kinase 1	Homo sapiens	17-21
9668345-4	1998	Cells engineered to express MAG on their surface adhered specifically to gangliosides bearing an alpha 2,3-linked N-acetylneuraminic acid on a terminal galactose, with the following relative potency: GQ1b alpha >> GD1a, GT1b >> GM3, GM4 (GM1, GD1b, GD3, and GQ1b did not support adhesion).	G(M1) Ganglioside	250-253	myelin associated glycoprotein	Homo sapiens	28-31
9668378-0	1998	GM1, like IGF-I and GDNF, prevents neuronal apoptosis.	G(M1) Ganglioside	0-3	insulin like growth factor 1	Homo sapiens	10-15
9668353-4	1998	Presence of 20-microM exogenous GM1 for 4 days in NGF and PDMP containing cell cultures led to an increase of cell-associated GM1(15-fold), GM2 (10-fold), GM3 (15 fold), GD1a (4-fold), GD2, GD1b, and GT1b (all 3-fold), and partially reversed the PDMP (and FB1) effects on neurite growth and GAP-43 distribution.	G(M1) Ganglioside	32-35	nerve growth factor	Homo sapiens	50-53
9668378-0	1998	GM1, like IGF-I and GDNF, prevents neuronal apoptosis.	G(M1) Ganglioside	0-3	glial cell derived neurotrophic factor	Homo sapiens	20-24
9668382-0	1998	Ganglioside GM1 potentiates the stimulatory effect of nerve growth factor on peripheral nerve regeneration in vivo.	G(M1) Ganglioside	0-15	nerve growth factor	Homo sapiens	54-73
9668387-0	1998	GM1 activates the MAP kinase cascade through a novel wortmannin-sensitive step upstream from c-Raf.	G(M1) Ganglioside	0-3	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	93-98
9668353-4	1998	Presence of 20-microM exogenous GM1 for 4 days in NGF and PDMP containing cell cultures led to an increase of cell-associated GM1(15-fold), GM2 (10-fold), GM3 (15 fold), GD1a (4-fold), GD2, GD1b, and GT1b (all 3-fold), and partially reversed the PDMP (and FB1) effects on neurite growth and GAP-43 distribution.	G(M1) Ganglioside	32-35	growth associated protein 43	Homo sapiens	291-297
9668353-4	1998	Presence of 20-microM exogenous GM1 for 4 days in NGF and PDMP containing cell cultures led to an increase of cell-associated GM1(15-fold), GM2 (10-fold), GM3 (15 fold), GD1a (4-fold), GD2, GD1b, and GT1b (all 3-fold), and partially reversed the PDMP (and FB1) effects on neurite growth and GAP-43 distribution.	G(M1) Ganglioside	126-129	nerve growth factor	Homo sapiens	50-53
9668356-3	1998	Systemic administration of GM1 ganglioside, 30 mg/kg, i.p., for 30 days, enhances the cholinergic neurochemical presynaptic markers, choline acetyltransferase, choline uptake, and acetylcholine, in the brain and spinal cord of aged 22-24-month-old Sprague-Dawley rats.	G(M1) Ganglioside	27-42	choline O-acetyltransferase	Rattus norvegicus	133-158
9668358-4	1998	Several growth factors [e.g., basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF)] and one species of ganglioside (GM1) have been shown to exert interactions with each other and also to exhibit neuroprotective effects against retinal ischemia in vivo and cerebral excitotoxicity in vitro.	G(M1) Ganglioside	135-138	epidermal growth factor like 1	Rattus norvegicus	72-95
9668358-4	1998	Several growth factors [e.g., basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF)] and one species of ganglioside (GM1) have been shown to exert interactions with each other and also to exhibit neuroprotective effects against retinal ischemia in vivo and cerebral excitotoxicity in vitro.	G(M1) Ganglioside	135-138	epidermal growth factor like 1	Rattus norvegicus	97-100
9668376-0	1998	Induction of Trk phosphorylation in rat brain by GM1 ganglioside.	G(M1) Ganglioside	49-64	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	13-16
9656423-7	1998	Co-labelling with CD4, CD8, and CD5 indicated an increase in the percentage of GM1 mutant cat thymocytes at this age which were CD5high, suggesting the presence of more mature cells.	G(M1) Ganglioside	79-82	CD4 molecule	Felis catus	18-21
9656423-7	1998	Co-labelling with CD4, CD8, and CD5 indicated an increase in the percentage of GM1 mutant cat thymocytes at this age which were CD5high, suggesting the presence of more mature cells.	G(M1) Ganglioside	79-82	CD5 molecule	Felis catus	32-35
9656423-13	1998	In GM1 mutant cats over 200 days of age, decreased labelling was observed when thymic mass was reduced and the CD4+CD8+ subpopulation, known to be very susceptible to apoptosis, was significantly decreased.	G(M1) Ganglioside	3-6	CD4 molecule	Felis catus	111-114
9565364-6	1998	As with influenza HA, adjuvanticity of LTB required GM1-binding activity, whereas GM1-binding was not essential for adjuvant activity of LT.	G(M1) Ganglioside	52-55	lymphotoxin B	Mus musculus	39-42
9591688-4	1998	These experiments have been done using cholera toxin B subunit (CTB) and annexin V as model proteins interacting with a monosialoganglioside (GM1) and dioleoylphosphatidylserine (DOPS), respectively.	G(M1) Ganglioside	142-145	phosphate cytidylyltransferase 1B, choline	Homo sapiens	53-68
9591688-4	1998	These experiments have been done using cholera toxin B subunit (CTB) and annexin V as model proteins interacting with a monosialoganglioside (GM1) and dioleoylphosphatidylserine (DOPS), respectively.	G(M1) Ganglioside	142-145	annexin A5	Homo sapiens	73-82
9556610-0	1998	Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture.	G(M1) Ganglioside	47-50	galectin 1	Homo sapiens	0-10
9556610-5	1998	Presence during cell culture of the sialidase inhibitor 2-deoxy-2,3-dehydro-N-acetylneuraminic acid or of the GM1-binding cholera toxin B subunit effected a decrease of the presentation of galectin-1 ligands by 30-50%.	G(M1) Ganglioside	110-113	galectin 1	Homo sapiens	189-199
9556610-6	1998	The assumption that GM1 is a major ligand for galectin-1 was reinforced by the correlation between the number of carbohydrate-dependent 125I-iodinated GM1-neoganglioprotein binding sites and the amount of immunoreactive surface galectin-1, the marked sensitivity of probe binding to the presence of anti-galectin-1 antibody, and the inhibition of cell adhesion to surface-immobilized GM1 by the antibody.	G(M1) Ganglioside	20-23	galectin 1	Homo sapiens	46-56
9556610-6	1998	The assumption that GM1 is a major ligand for galectin-1 was reinforced by the correlation between the number of carbohydrate-dependent 125I-iodinated GM1-neoganglioprotein binding sites and the amount of immunoreactive surface galectin-1, the marked sensitivity of probe binding to the presence of anti-galectin-1 antibody, and the inhibition of cell adhesion to surface-immobilized GM1 by the antibody.	G(M1) Ganglioside	20-23	galectin 1	Homo sapiens	228-238
9556610-6	1998	The assumption that GM1 is a major ligand for galectin-1 was reinforced by the correlation between the number of carbohydrate-dependent 125I-iodinated GM1-neoganglioprotein binding sites and the amount of immunoreactive surface galectin-1, the marked sensitivity of probe binding to the presence of anti-galectin-1 antibody, and the inhibition of cell adhesion to surface-immobilized GM1 by the antibody.	G(M1) Ganglioside	20-23	galectin 1	Homo sapiens	228-238
9556610-6	1998	The assumption that GM1 is a major ligand for galectin-1 was reinforced by the correlation between the number of carbohydrate-dependent 125I-iodinated GM1-neoganglioprotein binding sites and the amount of immunoreactive surface galectin-1, the marked sensitivity of probe binding to the presence of anti-galectin-1 antibody, and the inhibition of cell adhesion to surface-immobilized GM1 by the antibody.	G(M1) Ganglioside	151-154	galectin 1	Homo sapiens	46-56
9556610-7	1998	The results open the possibility that the carbohydrate-dependent interaction between ganglioside GM1 and galectin-1 may relay sialidase-dependent alterations in this cell system.	G(M1) Ganglioside	85-100	galectin 1	Homo sapiens	105-115
9629854-5	1998	This suggested that the band was N-glycolylneuraminic acid-containing GM1 [GM1(NeuGc)].	G(M1) Ganglioside	70-73	coenzyme Q10A	Mus musculus	75-85
9629854-8	1998	IgG anti-GM1(NeuGc) antibodies in sera from the GBS patients were significantly absorbed by GM1(NeuAc), indicative that the anti-GM1(NeuGc) antibodies cross-react with GM1(NeuAc).	G(M1) Ganglioside	9-12	coenzyme Q10A	Mus musculus	129-139
9629854-8	1998	IgG anti-GM1(NeuGc) antibodies in sera from the GBS patients were significantly absorbed by GM1(NeuAc), indicative that the anti-GM1(NeuGc) antibodies cross-react with GM1(NeuAc).	G(M1) Ganglioside	92-95	coenzyme Q10A	Mus musculus	9-19
9629854-8	1998	IgG anti-GM1(NeuGc) antibodies in sera from the GBS patients were significantly absorbed by GM1(NeuAc), indicative that the anti-GM1(NeuGc) antibodies cross-react with GM1(NeuAc).	G(M1) Ganglioside	92-95	coenzyme Q10A	Mus musculus	129-139
9629854-9	1998	N-Glycolylneuraminic acid-containing gangliosides are so highly immunogenic in humans that the injection of GM1(NeuGc) could induce the production of IgG anti-GM1(NeuGc) antibody, which cross-reacts with GM1(NeuAc).	G(M1) Ganglioside	108-111	coenzyme Q10A	Mus musculus	159-169
9585685-1	1998	An 18-month-old girl was diagnosed as having GM1 gangliosidosis, on the basis of the clinical symptoms of muscle stiffness, developmental retardation, hepatosplenomegaly, and kyphoscoliosis and a laboratory study that revealed a deficiency in the lysosomal degradative enzyme beta-galactosidase.	G(M1) Ganglioside	45-48	galactosidase beta 1	Homo sapiens	276-294
9529046-1	1998	Heat-labile enterotoxin subunit B (LTB) is a noncatalytic protein derived from Escherichia coli that binds to ganglioside GM1, a glycosphingolipid on the surface of mammalian cells.	G(M1) Ganglioside	122-125	lymphotoxin B	Mus musculus	35-38
9529046-10	1998	Apoptosis peaked at around 8 h after exposure to rLTB and incubation at 37 degrees C. Binding to ganglioside GM1 was essential for suppression, since rLTB/G33D, a mutant which does not bind GM1, failed to inhibit proliferation or induce apoptosis.	G(M1) Ganglioside	109-112	lymphotoxin beta	Rattus norvegicus	49-53
9529046-10	1998	Apoptosis peaked at around 8 h after exposure to rLTB and incubation at 37 degrees C. Binding to ganglioside GM1 was essential for suppression, since rLTB/G33D, a mutant which does not bind GM1, failed to inhibit proliferation or induce apoptosis.	G(M1) Ganglioside	109-112	lymphotoxin beta	Rattus norvegicus	150-154
9531314-3	1998	In vivo depletion of both NK cells and NK1+ alphabeta T cells of mice by anti-NK1.1 Ab greatly reduced the elevation of serum IFN-gamma induced by IL-12 and significantly reduced mortality after subsequent injection of LPS, whereas depletion of NK cells alone by anti-asialo GM1 Ab only partially decreased serum IFN-gamma, and lethality was not changed.	G(M1) Ganglioside	275-278	tachykinin 1	Mus musculus	39-42
9531314-3	1998	In vivo depletion of both NK cells and NK1+ alphabeta T cells of mice by anti-NK1.1 Ab greatly reduced the elevation of serum IFN-gamma induced by IL-12 and significantly reduced mortality after subsequent injection of LPS, whereas depletion of NK cells alone by anti-asialo GM1 Ab only partially decreased serum IFN-gamma, and lethality was not changed.	G(M1) Ganglioside	275-278	tachykinin 1	Mus musculus	78-81
9482259-0	1998	GM1 ganglioside potentiates trimethyltin-induced expression of interleukin-1 beta and the nerve growth factor in reactive astrocytes in the rat hippocampus: an immunocytochemical study.	G(M1) Ganglioside	0-15	interleukin 1 beta	Rattus norvegicus	63-81
9482259-0	1998	GM1 ganglioside potentiates trimethyltin-induced expression of interleukin-1 beta and the nerve growth factor in reactive astrocytes in the rat hippocampus: an immunocytochemical study.	G(M1) Ganglioside	0-15	nerve growth factor	Rattus norvegicus	90-109
9482259-2	1998	GM1 treatment also results in an increase of the number of IL-1 beta and NGF immunoreactive astrocytes.	G(M1) Ganglioside	0-3	interleukin 1 beta	Rattus norvegicus	59-68
9482259-2	1998	GM1 treatment also results in an increase of the number of IL-1 beta and NGF immunoreactive astrocytes.	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	73-76
9482259-4	1998	It is tempting to assume that enhancement of astroglial NGF expression by GM1 ganglioside may play a role in the protective action of GM1 against neurotoxic insult.	G(M1) Ganglioside	74-89	nerve growth factor	Rattus norvegicus	56-59
9482259-4	1998	It is tempting to assume that enhancement of astroglial NGF expression by GM1 ganglioside may play a role in the protective action of GM1 against neurotoxic insult.	G(M1) Ganglioside	74-77	nerve growth factor	Rattus norvegicus	56-59
10822616-1	1998	The interactions between the protein, cholera toxin B subunit attached to an atomic force microscope, AFM, cantilever, CTB and its receptor the ganglioside, GM1 have been measured in a dilute electrolyte solution, pH 5.5.	G(M1) Ganglioside	157-160	chitobiase	Homo sapiens	119-122
10822616-5	1998	This gives us confidence that in the earlier experiments, a specific interaction between the CTB and GM1 was measured.	G(M1) Ganglioside	101-104	chitobiase	Homo sapiens	93-96
9403993-2	1997	Capitalizing on the readily available ganglioside, GM1, we have devised a simple synthesis of labeled GM1 analogues with sulfur in place of oxygen in their linkage to the ceramide residue (SGM1).	G(M1) Ganglioside	51-54	growth differentiation factor 6	Homo sapiens	189-193
10959234-2	1998	This study focuses on antibodies to galactocerebroside (GalC) and sulfatide and on the B subunit of cholera toxin (CTB), which reacts with GM1 ganglioside, to examine whether these agents have any direct effects on Schwann cells (SC) as measured by Ca++ responses.	G(M1) Ganglioside	139-154	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	115-118
10959234-8	1998	Since surface binding of CTB was very low and sparsely punctate in Schwann cells +/- 8 Br-cAMP, we tested whether increasing levels of GM1 ganglioside on the surface would lead to induction of a Ca++ signaling pathway, as reported for fibroblasts.	G(M1) Ganglioside	135-150	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	25-28
9607025-4	1998	The protection was impaired by treatment of the mice with either anti-CD4, anti-CD8 IgG, anti asialo GM1 antiserum or dextrane sulfate, which deplete the CD4+, CD8+ and NK cells or the macrophages, respectively.	G(M1) Ganglioside	101-104	CD4 antigen	Mus musculus	154-157
9450547-1	1997	We previously identified a novel amyloid beta-protein (A beta), that binds to GM1 ganglioside, in brains exhibiting the early pathological changes of AD.	G(M1) Ganglioside	78-93	amyloid beta precursor protein	Homo sapiens	55-61
9450547-2	1997	In this study, we raised monoclonal antibodies, using membrane fractions containing abundant GM1 ganglioside-bound A beta as antigens.	G(M1) Ganglioside	93-108	amyloid beta precursor protein	Homo sapiens	115-121
9450547-4	1997	Furthermore, this antibody recognizes the A beta bound to lipid vesicles containing GM1 ganglioside, and unexpectedly, phosphatidylinositol.	G(M1) Ganglioside	84-99	amyloid beta precursor protein	Homo sapiens	42-48
9404724-2	1997	In previous studies, we showed a nerve growth factor (NGF)-induced sprouting and hypertrophy of presynaptic terminals in the cholinergic fibres of the rat neocortex following stroke-type lesions, effects that were potentiated by the monosialoganglioside GM1.	G(M1) Ganglioside	254-257	nerve growth factor	Rattus norvegicus	33-52
9404724-2	1997	In previous studies, we showed a nerve growth factor (NGF)-induced sprouting and hypertrophy of presynaptic terminals in the cholinergic fibres of the rat neocortex following stroke-type lesions, effects that were potentiated by the monosialoganglioside GM1.	G(M1) Ganglioside	254-257	nerve growth factor	Rattus norvegicus	54-57
9562471-6	1998	The present results strongly suggest that Abeta binds to a GM1 ganglioside in such a way that the bound Abeta is only recognized by BAN052, of the monoclonal antibodies used in this study.	G(M1) Ganglioside	59-74	amyloid beta precursor protein	Homo sapiens	42-47
9562471-6	1998	The present results strongly suggest that Abeta binds to a GM1 ganglioside in such a way that the bound Abeta is only recognized by BAN052, of the monoclonal antibodies used in this study.	G(M1) Ganglioside	59-74	amyloid beta precursor protein	Homo sapiens	104-109
9427377-0	1997	GM1 increases the content and mRNA of NGF in the brain of aged rats.	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	38-41
9427377-6	1997	GM1 treatment partially restored NGF and NGF mRNA in frontal cortex and hippocampus in the aged brain, but treatment had no effect on Trk protein.	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	33-36
9427377-6	1997	GM1 treatment partially restored NGF and NGF mRNA in frontal cortex and hippocampus in the aged brain, but treatment had no effect on Trk protein.	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	41-44
9403993-2	1997	Capitalizing on the readily available ganglioside, GM1, we have devised a simple synthesis of labeled GM1 analogues with sulfur in place of oxygen in their linkage to the ceramide residue (SGM1).	G(M1) Ganglioside	102-105	growth differentiation factor 6	Homo sapiens	189-193
9312075-5	1997	Introduction of the cDNA clone into a mouse melanoma line B16 previously transfected with a GM2/GD2 synthase gene resulted in the neo-synthesis of GM1.	G(M1) Ganglioside	147-150	cytochrome b5 domain containing 2	Mus musculus	92-95
9312075-6	1997	Co-transfection of the cell line with pM1T-9 and a GD3 synthase cDNA resulted in the expression of GD1b as well as GM1.	G(M1) Ganglioside	115-118	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	51-63
9312075-7	1997	Moreover, introduction of pM1T-9 into L cell (lacking GM3 synthase), previously transfected with GM2/GD2 synthase gene, resulted in the definite expression of asialo-GM1.	G(M1) Ganglioside	166-169	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Rattus norvegicus	54-66
9312075-7	1997	Moreover, introduction of pM1T-9 into L cell (lacking GM3 synthase), previously transfected with GM2/GD2 synthase gene, resulted in the definite expression of asialo-GM1.	G(M1) Ganglioside	166-169	cytochrome b5 domain containing 2	Mus musculus	97-100
9308001-5	1997	GM1, GM2 and GM3 also suppressed dose-dependently the polymerization of both actin and vimentin.	G(M1) Ganglioside	0-3	vimentin	Rattus norvegicus	87-95
9347079-0	1997	Activation of arachidonic acid-specific phospholipase A2 in human neuroblastoma cells after chronic alcohol exposure: prevention by GM1 ganglioside.	G(M1) Ganglioside	132-147	phospholipase A2 group IB	Homo sapiens	40-56
9347079-6	1997	It was also found that co-treatment of neuroblastoma cells with ganglioside GM1 reduced the EtOH-induced activation of arachidonyl-specific PLA2 activity.	G(M1) Ganglioside	64-79	phospholipase A2 group IB	Homo sapiens	140-144
9347079-8	1997	Ganglioside GM1, in part, may exert its neuroprotective effects by modulating arachidonyl-specific PLA2 activity in chronic EtOH-exposed neuroblastoma cells.	G(M1) Ganglioside	12-15	phospholipase A2 group IB	Homo sapiens	99-103
9308001-6	1997	The inhibitory activities of GM1 and GM2 on the polymerization of actin or vimentin were greater than GM3, as in the case of polymerization of MF or GF.	G(M1) Ganglioside	29-32	vimentin	Rattus norvegicus	75-83
9358541-1	1997	PURPOSE: To determine whether the non-toxic pentameric B subunit of Cholera toxin (CTB) binding to ganglioside GM1 on both the lipid vesicles and epithelial cells may provide a means to target lipid vesicles to mucosal cells expressing surface GM1.	G(M1) Ganglioside	111-114	phosphate cytidylyltransferase 1B, choline	Homo sapiens	83-86
9358541-1	1997	PURPOSE: To determine whether the non-toxic pentameric B subunit of Cholera toxin (CTB) binding to ganglioside GM1 on both the lipid vesicles and epithelial cells may provide a means to target lipid vesicles to mucosal cells expressing surface GM1.	G(M1) Ganglioside	244-247	phosphate cytidylyltransferase 1B, choline	Homo sapiens	83-86
9358541-3	1997	Inter-vesicle cross-linking due to pentameric CTB binding to these GM1 vesicles was determined with a sub-micron particle analyzer.	G(M1) Ganglioside	67-70	phosphate cytidylyltransferase 1B, choline	Homo sapiens	46-49
9358541-4	1997	Association of CTB to GM1 vesicles was analyzed with continuous sucrose gradient centrifugation.	G(M1) Ganglioside	22-25	phosphate cytidylyltransferase 1B, choline	Homo sapiens	15-18
9358541-5	1997	CTB-mediated binding of GM1 vesicles to human mucosal epithelial cells (Caco-2 and HT-29), mucous membranes of mouse trachea, and nasal tissues were detected with fluorescent labeled vesicles.	G(M1) Ganglioside	24-27	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-3
9358541-7	1997	At a 30-to-1 mole ratio of membrane-bound GM1-to-CTB, optimum increase in GM1 vesicle aggregation, was detected.	G(M1) Ganglioside	42-45	phosphate cytidylyltransferase 1B, choline	Homo sapiens	49-52
9358541-7	1997	At a 30-to-1 mole ratio of membrane-bound GM1-to-CTB, optimum increase in GM1 vesicle aggregation, was detected.	G(M1) Ganglioside	74-77	phosphate cytidylyltransferase 1B, choline	Homo sapiens	49-52
9358541-8	1997	Under such conditions, all the added CTB molecules were associated with GM1 vesicles.	G(M1) Ganglioside	72-75	phosphate cytidylyltransferase 1B, choline	Homo sapiens	37-40
9358541-11	1997	CTB associated GM1-vesicles bind to mucosal epithelial cells HT-29 and Caco-2 with similar affinity [Kd = 7.8 x 10(-4) M lipid (Caco-2) and 7.6 x 10(-4) M lipid (HT-29)].	G(M1) Ganglioside	15-18	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-3
9358541-13	1997	CONCLUSIONS: The CTB-mediated GM1 binding to multiple membrane surfaces provides selective localization of GM1 vesicles to GM1 expressing mucosal cells and tissues.	G(M1) Ganglioside	30-33	phosphate cytidylyltransferase 1B, choline	Homo sapiens	17-20
9358541-13	1997	CONCLUSIONS: The CTB-mediated GM1 binding to multiple membrane surfaces provides selective localization of GM1 vesicles to GM1 expressing mucosal cells and tissues.	G(M1) Ganglioside	107-110	phosphate cytidylyltransferase 1B, choline	Homo sapiens	17-20
9358541-13	1997	CONCLUSIONS: The CTB-mediated GM1 binding to multiple membrane surfaces provides selective localization of GM1 vesicles to GM1 expressing mucosal cells and tissues.	G(M1) Ganglioside	107-110	phosphate cytidylyltransferase 1B, choline	Homo sapiens	17-20
9201997-5	1997	In contrast, sialoadhesin had less exacting specificity, binding to gangliosides that bear either terminal alpha2,3- or alpha2,8-linked sialic acids with the following rank-order potency of binding: GQ1balpha > GD1a = GD1b = GT1b = GM3 = GM4 > GD3 = GQ1b >> GM1 (nonbinder).	G(M1) Ganglioside	270-273	sialic acid binding Ig like lectin 1	Homo sapiens	13-25
9176164-8	1997	Ouabain binds with high affinity to gM1/2+NK beta 1 [ouabain binding affinity (Kd) = 9.5 nM] but not to gM1/2+HK beta.	G(M1) Ganglioside	36-39	ATPase Na+/K+ transporting subunit beta 1	Rattus norvegicus	42-51
9202301-0	1997	Ganglioside GM1 activates the mitogen-activated protein kinase Erk2 and p70 S6 kinase in U-1242 MG human glioma cells.	G(M1) Ganglioside	12-15	mitogen-activated protein kinase 1	Homo sapiens	63-67
9202301-0	1997	Ganglioside GM1 activates the mitogen-activated protein kinase Erk2 and p70 S6 kinase in U-1242 MG human glioma cells.	G(M1) Ganglioside	12-15	ribosomal protein S6 kinase B1	Homo sapiens	72-85
9202301-4	1997	Treatment of quiescent U-1242 MG cells with GM1 caused activation of the mitogen-activated protein (MAP) kinase isoform Erk2.	G(M1) Ganglioside	44-47	mitogen-activated protein kinase 1	Homo sapiens	120-124
9202301-5	1997	Pretreatment with the specific MAP kinase kinase inhibitor PD98059 prevented the GM1-stimulated Erk2 activation and GM1-stimulated DNA synthesis.	G(M1) Ganglioside	81-84	mitogen-activated protein kinase 1	Homo sapiens	96-100
9202301-6	1997	GM1 treatment stimulated another distinct signaling pathway leading to activation of p70 S6 kinase (p70s6k), and this was prevented by pretreatment with rapamycin.	G(M1) Ganglioside	0-3	ribosomal protein S6 kinase B1	Homo sapiens	85-98
9202301-6	1997	GM1 treatment stimulated another distinct signaling pathway leading to activation of p70 S6 kinase (p70s6k), and this was prevented by pretreatment with rapamycin.	G(M1) Ganglioside	0-3	ribosomal protein S6 kinase B1	Homo sapiens	100-106
9192627-2	1997	One form, denoted GM1-IL-5, is a CD-loop expanded form, in which an 8-residue linker designed for flexibility was inserted between residues 85 and 86.	G(M1) Ganglioside	18-21	interleukin 5	Homo sapiens	22-26
9185170-4	1997	The other glycosyltransferase activities assayed were the galactosyltransferase (Gal-T2) that converts GM2 to GM1 and the N-acetylneuraminyltransferase (Sialyl-T1) that converts lactosylceramide to GM3.	G(M1) Ganglioside	110-113	uncharacterized protein	Drosophila melanogaster	81-87
9203065-1	1997	Three unrelated North American cases with slowly progressive forms of GM1 gangliosidosis were found to have two unique point mutations and a 9 bp insertion in the coding region of the gene encoding beta-galactosidase.	G(M1) Ganglioside	70-73	galactosidase beta 1	Homo sapiens	198-216
9166727-0	1997	Ganglioside GM1 enhances induction by nerve growth factor of a putative dimer of TrkA.	G(M1) Ganglioside	0-15	nerve growth factor	Rattus norvegicus	38-57
9166727-0	1997	Ganglioside GM1 enhances induction by nerve growth factor of a putative dimer of TrkA.	G(M1) Ganglioside	0-15	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	81-85
9166727-1	1997	GM1 enhances nerve growth factor (NGF)-stimulated neuritogenesis and prevents apoptotic death of PC12 cells; both may be due to enhancement of TrkA dimerization.	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	13-32
9166727-1	1997	GM1 enhances nerve growth factor (NGF)-stimulated neuritogenesis and prevents apoptotic death of PC12 cells; both may be due to enhancement of TrkA dimerization.	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	34-37
9166727-1	1997	GM1 enhances nerve growth factor (NGF)-stimulated neuritogenesis and prevents apoptotic death of PC12 cells; both may be due to enhancement of TrkA dimerization.	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	143-147
9166727-2	1997	In this study, we examined the effect of GM1 on NGF-induced TrkA dimerization in Trk-PC12 (6-24) cells.	G(M1) Ganglioside	41-44	nerve growth factor	Rattus norvegicus	48-51
9166727-2	1997	In this study, we examined the effect of GM1 on NGF-induced TrkA dimerization in Trk-PC12 (6-24) cells.	G(M1) Ganglioside	41-44	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	60-64
9166727-2	1997	In this study, we examined the effect of GM1 on NGF-induced TrkA dimerization in Trk-PC12 (6-24) cells.	G(M1) Ganglioside	41-44	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	60-63
9166727-3	1997	NGF increased tyrosine phosphorylation of the 140-kDa protein (TrkA monomer), and preincubation with GM1 potentiated this effect.	G(M1) Ganglioside	101-104	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	63-67
9166727-4	1997	Adding the protein cross-linker bis(sulfosuccinimidyl) suberate with NGF resulted in the appearance of two major bands (220 and 330 kDa) when probed with antibodies against TrkA or phosphotyrosine, and GM1 also enhanced this effect.	G(M1) Ganglioside	202-205	nerve growth factor	Rattus norvegicus	69-72
9166727-7	1997	Our results suggest that GM1 is augmenting the effects of NGF on PC12 cells by enhancing the dimerization and activation of the TrkA receptor.	G(M1) Ganglioside	25-28	nerve growth factor	Rattus norvegicus	58-61
9166727-7	1997	Our results suggest that GM1 is augmenting the effects of NGF on PC12 cells by enhancing the dimerization and activation of the TrkA receptor.	G(M1) Ganglioside	25-28	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	128-132
9179843-6	1997	In addition, a mutant LTB with a single Gly-33-->Asp substitution that completely lacked affinity for both GM1 and non-GM1 glycosphingolipids could still bind to receptors in the intestinal cell membranes and to polyglycosylceramides.	G(M1) Ganglioside	110-113	lymphotoxin-beta	Oryctolagus cuniculus	22-25
9191258-0	1997	Ganglioside GM1 potentiates the effect of IL-1 beta on neutral sphingomyelinase activity in rat brain synaptosomes.	G(M1) Ganglioside	12-15	interleukin 1 beta	Rattus norvegicus	42-51
9251249-8	1997	GM1, which is a ceramide bound glucosidically to the oligosaccharide moiety, was a strong non-competitive inhibitor of PLC delta 1.	G(M1) Ganglioside	0-3	phospholipase C delta 1	Homo sapiens	119-130
9149388-3	1997	These GM1 derivatives could be hydrolyzed to the corresponding GM3 derivatives by treatment with GM1-beta-galactosidase and beta-hexosaminidases.	G(M1) Ganglioside	6-9	galactosidase beta 1	Homo sapiens	101-119
9109910-4	1997	Further, over 40% more serums from patients with MMN have high-titer serum IgM binding to GGC than to GM1 alone.	G(M1) Ganglioside	102-105	gamma-glutamylcyclotransferase	Homo sapiens	90-93
9109910-7	1997	We conclude that serum IgM anti-GGC autoantibodies have specificity for MMN and their binding is strongly influenced by the lipid environment of GM1 ganglioside.	G(M1) Ganglioside	145-160	gamma-glutamylcyclotransferase	Homo sapiens	32-35
9149388-3	1997	These GM1 derivatives could be hydrolyzed to the corresponding GM3 derivatives by treatment with GM1-beta-galactosidase and beta-hexosaminidases.	G(M1) Ganglioside	97-100	galactosidase beta 1	Homo sapiens	101-119
9065554-10	1997	This binding was blocked by cholera toxin, suggesting that the organism contained the Gal(beta1-3)GalNAc epitope of GM1 in its lipopolysaccharide.	G(M1) Ganglioside	116-119	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	90-97
9003045-0	1997	Nonmuscle myosin heavy chain B is recognized by a monoclonal antibody that inhibits GM1-enhanced neuritogenesis.	G(M1) Ganglioside	84-87	myosin, heavy polypeptide 10, non-muscle	Mus musculus	0-30
9003426-6	1997	When TX100 extracts from Jurkat cells were subjected to centrifugation to equilibrium in sucrose gradients we found MAL exclusively in the floating fractions, together with molecules characteristic of the T-cell insoluble complexes, such as the tyrosine kinase p56lck, the glycosylphosphatidylinositol-anchored protein CD59 and the ganglioside GM1.	G(M1) Ganglioside	344-347	mal, T cell differentiation protein	Homo sapiens	116-119
9117403-5	1996	In contrast, GM1 modestly increased both the activity and mRNA for AAAD.	G(M1) Ganglioside	13-16	dopa decarboxylase	Rattus norvegicus	67-71
9117403-6	1996	In the MPP+-treated cultures, GM1 induced a partial recovery of TH and AAAD activity and increased mRNA for both above unlesioned control levels.	G(M1) Ganglioside	30-33	dopa decarboxylase	Rattus norvegicus	71-75
9117403-7	1996	Our studies demonstrate that GM1 upregulates the synthetic enzymes for dopamine in MPP+-lesioned embryonic mesencephalic cultures, and suggest that TH and AAAD respond differentially to the neurotoxin insult.	G(M1) Ganglioside	29-32	dopa decarboxylase	Rattus norvegicus	155-159
9064322-3	1996	Coupling of antigen-containing particles to the pentameric binding subunit of cholera toxin (CTB) has been proposed as a means for increasing antigen uptake because the CTB receptor, ganglioside GM1, is a glycolipid present in apical membranes of all intestinal epithelial cells.	G(M1) Ganglioside	195-198	chitobiase	Homo sapiens	93-96
8884181-4	1996	GM2 and GM1 inhibit the PDGF-BB-dependent receptor tyrosine autophosphorylation, stimulation of the PLC-gamma 1, increase of inositol-1,4,5-trisphosphate (InsP3), elevation in cytosolic free Ca2+ ([Ca2+]i), expression of the immediate early growth response gene c-fos and cell proliferation with the following rank order of potency GM2 > GM1.	G(M1) Ganglioside	8-11	phospholipase C, gamma 1	Rattus norvegicus	100-111
8884181-4	1996	GM2 and GM1 inhibit the PDGF-BB-dependent receptor tyrosine autophosphorylation, stimulation of the PLC-gamma 1, increase of inositol-1,4,5-trisphosphate (InsP3), elevation in cytosolic free Ca2+ ([Ca2+]i), expression of the immediate early growth response gene c-fos and cell proliferation with the following rank order of potency GM2 > GM1.	G(M1) Ganglioside	8-11	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	262-267
9064322-3	1996	Coupling of antigen-containing particles to the pentameric binding subunit of cholera toxin (CTB) has been proposed as a means for increasing antigen uptake because the CTB receptor, ganglioside GM1, is a glycolipid present in apical membranes of all intestinal epithelial cells.	G(M1) Ganglioside	195-198	chitobiase	Homo sapiens	169-172
8635555-0	1996	The ganglioside GM1 enhances microtubule networks and changes the morphology of Neuro-2a cells in vitro by altering the distribution of MAP2.	G(M1) Ganglioside	16-19	microtubule-associated protein 2	Mus musculus	136-140
8906573-3	1996	Treatment of MG cells with GG (GM1, GT1b) and asialoGM1 resulted in modifications of several aspects of cellular responses to EGF- and FGF-receptor (R) activation: mitogenesis, cell migration, tyrosine phosphorylation of the EGF-R and FGF-R and even their cellular substrates were particularly influenced by GG.	G(M1) Ganglioside	31-34	epidermal growth factor receptor	Homo sapiens	126-147
8906573-3	1996	Treatment of MG cells with GG (GM1, GT1b) and asialoGM1 resulted in modifications of several aspects of cellular responses to EGF- and FGF-receptor (R) activation: mitogenesis, cell migration, tyrosine phosphorylation of the EGF-R and FGF-R and even their cellular substrates were particularly influenced by GG.	G(M1) Ganglioside	31-34	epidermal growth factor	Homo sapiens	126-129
8760602-12	1996	Preliminary results showed that mice, pre-treated with 4 Gy irradiation and the anti-asialo GM1 injection, were tolerant to radioimmunotherapy with a total dose of 500 muCi 131I labeled anti-CEA intact MAbs given in 3 injections.	G(M1) Ganglioside	92-95	carcinoembryonic antigen gene family	Mus musculus	191-194
9102850-3	1996	The neurological examination revealed flaccid quadriplegia without affection of the sensory system, and the additional investigation showed mild increase of the CSF protein content, demyelination of the peripheral motor nerves and significantly increased titer of the serum and CSF anti-GM1 antibodies.	G(M1) Ganglioside	287-290	colony stimulating factor 2	Homo sapiens	278-281
8639583-2	1996	SPR shows that cholera toxin preferably binds to gangliosides in the following sequence: GM1 > GM2 > GD1A > GM3 > GT1B > GD1B > asialo-GM1.	G(M1) Ganglioside	89-92	sepiapterin reductase	Homo sapiens	0-3
8639583-2	1996	SPR shows that cholera toxin preferably binds to gangliosides in the following sequence: GM1 > GM2 > GD1A > GM3 > GT1B > GD1B > asialo-GM1.	G(M1) Ganglioside	153-156	sepiapterin reductase	Homo sapiens	0-3
8734845-2	1996	Greater differences were observed in the younger age, where ethanol treatment caused a significant increase of C20:1 LCB in GM1 ganglioside of synaptosomes and microsomes and in GD1a of myelin.	G(M1) Ganglioside	124-139	clathrin, light chain B	Rattus norvegicus	117-120
9081368-3	1996	In this descriptive study, we investigated the effects of six exogenous gangliosides (GM1, GM3, GD1a, GD1b, GD3 and GT1b) on the secretion of MMP-2 (72 kDa gelatinase or gelatinase-A) and MMP-9 (92 kDa gelatinase or gelatinase-B).	G(M1) Ganglioside	86-89	matrix metallopeptidase 2	Homo sapiens	142-147
8635555-2	1996	Exposure of cells to GM1 for 24 h resulted in an increased microtubular network and level of tubulin, a redistribution of MAP2 immunoreactivity from perikarya to distal neuritic processes, and an increased MAP2 gold label in the subplasmalemmal cytoplasm, neuritic spines, and growth cones.	G(M1) Ganglioside	21-24	microtubule-associated protein 2	Mus musculus	122-126
8635555-2	1996	Exposure of cells to GM1 for 24 h resulted in an increased microtubular network and level of tubulin, a redistribution of MAP2 immunoreactivity from perikarya to distal neuritic processes, and an increased MAP2 gold label in the subplasmalemmal cytoplasm, neuritic spines, and growth cones.	G(M1) Ganglioside	21-24	microtubule-associated protein 2	Mus musculus	206-210
8635555-6	1996	Furthermore, the enhanced presence of MAP2 in regions known to be rich in microfilaments following GM1 treatment suggests that an interaction of MAP2 with microfilaments may be necessary for early neurite formation.	G(M1) Ganglioside	99-102	microtubule-associated protein 2	Mus musculus	38-42
8635555-6	1996	Furthermore, the enhanced presence of MAP2 in regions known to be rich in microfilaments following GM1 treatment suggests that an interaction of MAP2 with microfilaments may be necessary for early neurite formation.	G(M1) Ganglioside	99-102	microtubule-associated protein 2	Mus musculus	145-149
8701776-9	1996	Taken together, the data suggest that the metastatic ability of colon 26 cells pretreated with IFN-gamma is significantly higher due to the resistance to asialo GM1-positive cells accompanied with de novo protein synthesis.	G(M1) Ganglioside	161-164	interferon gamma	Mus musculus	95-104
8719707-2	1996	Two long-chain bases, LCB, were components of the five major gangliosides GM1, GD1a, GD1b, GT1b and GQ1b, these being the C18:1 LCB and C20:1 LCB.	G(M1) Ganglioside	74-77	clathrin, light chain B	Rattus norvegicus	22-25
8777139-5	1996	The galactose residues of asialo-hCG were reacted with NeuAc-hydrazone or a hydrazone of the oligosaccharide from the ganglioside GM1 (Gal(beta 1-3)GalNAc(beta 1-4) [NeuAc(alpha 2-3)]Gal(beta 1-4)Glc).	G(M1) Ganglioside	130-133	chorionic gonadotropin subunit beta 5	Homo sapiens	33-36
8692291-10	1996	These findings indicate that actions of bFGF may be potentiated by the addition of GM1 in both primary neuronal cultures and radial maze task performance.	G(M1) Ganglioside	83-86	fibroblast growth factor 2	Rattus norvegicus	40-44
8826527-5	1996	We have found evidence that part of the survival-promoting activity of GM1 is dependent on the presence, dimerization, and activation of the Trk NGF receptor tyrosine kinase and that GM1 causes a detectable increase in Trk receptor autophosphorylation.	G(M1) Ganglioside	71-74	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	141-144
8826527-5	1996	We have found evidence that part of the survival-promoting activity of GM1 is dependent on the presence, dimerization, and activation of the Trk NGF receptor tyrosine kinase and that GM1 causes a detectable increase in Trk receptor autophosphorylation.	G(M1) Ganglioside	183-186	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	219-222
8826527-6	1996	We postulate that exogenously supplied GM1 causes increased ligand-independent dimerization of Trk molecules within membranes, thereby leading to its activation and promotion of survival.	G(M1) Ganglioside	39-42	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	95-98
7499860-9	1995	Furthermore, anti-asialo GM1 Ab plus complement treatment abolished IFN-gamma production after stimulation with viable BCG, indicating that the NK cell was the major source of IFN-gamma, and its production was triggered only by stimulation with viable BCG.	G(M1) Ganglioside	25-28	interferon gamma	Rattus norvegicus	68-77
8750718-1	1995	A new de-N-acetylated glycosphingolipid termed WILD20, a breakdown product of GM1 obtained through alkaline hydrolysis, and characterized by nuclear magnetic resonance, mass spectrometry and elementary analysis, was found to inhibit phospholipase A2 via phosphokinase C translocation blockade.	G(M1) Ganglioside	78-81	phospholipase A2 group IB	Homo sapiens	233-249
7499860-9	1995	Furthermore, anti-asialo GM1 Ab plus complement treatment abolished IFN-gamma production after stimulation with viable BCG, indicating that the NK cell was the major source of IFN-gamma, and its production was triggered only by stimulation with viable BCG.	G(M1) Ganglioside	25-28	interferon gamma	Rattus norvegicus	176-185
8536366-6	1995	Our results indicate that the acquisition of suppressor activity requires the interaction of Ia+CD11b+Fc gamma R+IgG- asialo GM1- adherent cells with Thy1-CD4-CD8-IgG-Ia- asialo GM1-Fc gamma R+CD11b+ non-adherent cells.	G(M1) Ganglioside	178-181	integrin subunit alpha M	Homo sapiens	96-101
8847737-8	1995	Furthermore, only MBP interacted with ganglioside GM1, whereas MBP did not interact with this ganglioside.	G(M1) Ganglioside	50-53	myelin basic protein	Homo sapiens	18-21
8847737-9	1995	These results are consistent with the view that ganglioside GM1 mediates the mitogenic effects of MBP, while the FGF receptor mediates the mitogenic effect of MBP.	G(M1) Ganglioside	60-63	myelin basic protein	Homo sapiens	98-101
8847738-3	1995	MBP and MBP peptides (1-44 and 88-151) have been shown to interact with ganglioside GM1 (Tzeng et al.	G(M1) Ganglioside	84-87	myelin basic protein	Homo sapiens	0-3
8847738-3	1995	MBP and MBP peptides (1-44 and 88-151) have been shown to interact with ganglioside GM1 (Tzeng et al.	G(M1) Ganglioside	84-87	myelin basic protein	Homo sapiens	8-11
8536366-6	1995	Our results indicate that the acquisition of suppressor activity requires the interaction of Ia+CD11b+Fc gamma R+IgG- asialo GM1- adherent cells with Thy1-CD4-CD8-IgG-Ia- asialo GM1-Fc gamma R+CD11b+ non-adherent cells.	G(M1) Ganglioside	178-181	Thy-1 cell surface antigen	Homo sapiens	150-154
8536366-6	1995	Our results indicate that the acquisition of suppressor activity requires the interaction of Ia+CD11b+Fc gamma R+IgG- asialo GM1- adherent cells with Thy1-CD4-CD8-IgG-Ia- asialo GM1-Fc gamma R+CD11b+ non-adherent cells.	G(M1) Ganglioside	125-128	Thy-1 cell surface antigen	Homo sapiens	150-154
8536366-6	1995	Our results indicate that the acquisition of suppressor activity requires the interaction of Ia+CD11b+Fc gamma R+IgG- asialo GM1- adherent cells with Thy1-CD4-CD8-IgG-Ia- asialo GM1-Fc gamma R+CD11b+ non-adherent cells.	G(M1) Ganglioside	178-181	CD4 molecule	Homo sapiens	155-158
8536366-6	1995	Our results indicate that the acquisition of suppressor activity requires the interaction of Ia+CD11b+Fc gamma R+IgG- asialo GM1- adherent cells with Thy1-CD4-CD8-IgG-Ia- asialo GM1-Fc gamma R+CD11b+ non-adherent cells.	G(M1) Ganglioside	125-128	CD4 molecule	Homo sapiens	155-158
8536366-6	1995	Our results indicate that the acquisition of suppressor activity requires the interaction of Ia+CD11b+Fc gamma R+IgG- asialo GM1- adherent cells with Thy1-CD4-CD8-IgG-Ia- asialo GM1-Fc gamma R+CD11b+ non-adherent cells.	G(M1) Ganglioside	125-128	CD8a molecule	Homo sapiens	159-162
8536366-6	1995	Our results indicate that the acquisition of suppressor activity requires the interaction of Ia+CD11b+Fc gamma R+IgG- asialo GM1- adherent cells with Thy1-CD4-CD8-IgG-Ia- asialo GM1-Fc gamma R+CD11b+ non-adherent cells.	G(M1) Ganglioside	125-128	integrin subunit alpha M	Homo sapiens	193-198
8536366-6	1995	Our results indicate that the acquisition of suppressor activity requires the interaction of Ia+CD11b+Fc gamma R+IgG- asialo GM1- adherent cells with Thy1-CD4-CD8-IgG-Ia- asialo GM1-Fc gamma R+CD11b+ non-adherent cells.	G(M1) Ganglioside	178-181	CD8a molecule	Homo sapiens	159-162
7594525-0	1995	Triggering of a sustained calcium response through a p56lck-dependent pathway by exogenous ganglioside GM1 in human T lymphocytes.	G(M1) Ganglioside	91-106	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	53-59
7594525-5	1995	A marked conversion of the T cell-specific tyrosine kinase p56lck to a slow migrating 60-kDa form is also found following GM1 addition.	G(M1) Ganglioside	122-125	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-65
7594525-7	1995	Finally, the marked calcium response and tyrosine phosphorylations triggered by GM1 cannot be observed in a p56lck-negative T cell variant.	G(M1) Ganglioside	80-83	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-114
7594525-8	1995	Together these results demonstrate that the monosialoganglioside GM1 can behave as an authentic activation molecule on human T lymphocytes, likely through a p56lck tyrosine kinase-dependent pathway.	G(M1) Ganglioside	65-68	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	157-163
8622782-0	1995	GM1 and NGF synergism on choline acetyltransferase and choline uptake in aged brain.	G(M1) Ganglioside	0-3	choline O-acetyltransferase	Rattus norvegicus	25-50
8522171-5	1995	Plasmids encoding proteins with peptides inserted between aa 53 and 64 in CTB gave rise to stable proteins which reacted with CTB-specific monoclonal antibodies (mAb) and bound to GM1 gangliosides (GM1), indicating that insertions between these positions do not drastically alter the conformation or the receptor-binding properties of native CTB.	G(M1) Ganglioside	180-196	phosphate cytidylyltransferase 1B, choline	Homo sapiens	74-77
8522171-5	1995	Plasmids encoding proteins with peptides inserted between aa 53 and 64 in CTB gave rise to stable proteins which reacted with CTB-specific monoclonal antibodies (mAb) and bound to GM1 gangliosides (GM1), indicating that insertions between these positions do not drastically alter the conformation or the receptor-binding properties of native CTB.	G(M1) Ganglioside	180-183	phosphate cytidylyltransferase 1B, choline	Homo sapiens	74-77
8522171-8	1995	The reactivity of the inserted epitopes with epitope-specific mAb in GM1-ELISA and immunoblots varied greatly between hybrid proteins and depended on the position in CTB and the aa composition of the inserted peptides.	G(M1) Ganglioside	69-72	phosphate cytidylyltransferase 1B, choline	Homo sapiens	166-169
7585532-5	1995	Methotrexate prevented the IL-2-induced increase in the number of splenocytes that were asialo GM1+ but had no effect on Lyt 2+ or L3T4+ cell content.	G(M1) Ganglioside	95-99	interleukin 2	Mus musculus	27-31
8622782-3	1995	GM1 ganglioside infused into the lateral ventricle, at a dose that is ineffective alone, together with NGF synergistically enhances the effect of NGF on ChAT and HAChU activities in the brain of aged animals.	G(M1) Ganglioside	0-15	nerve growth factor	Rattus norvegicus	146-149
7543907-3	1995	IgG subclass distribution of the anti-GM1 antibody in GBS patients is mainly restricted to IgG1 and IgG3.	G(M1) Ganglioside	38-41	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	100-104
7665899-6	1995	The biological activity of CT or CTB bound to liposomes was confirmed by a hemagglutination assay using GM1-enriched human erythrocytes.	G(M1) Ganglioside	104-107	chitobiase	Homo sapiens	33-36
7654064-4	1995	The PEN O:4/59 serotype, isolated from the stools of a Guillain-Barre syndrome patient, inhibited 63 to 93% of the anti-GM1 activity in 6 of 11 patients.	G(M1) Ganglioside	120-123	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	4-7
7654064-5	1995	The PEN O:41 inhibited 63 to 100% of the anti-GM1 antibody activity in 9 of 11 patients.	G(M1) Ganglioside	46-49	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	4-7
7654064-6	1995	The PEN O:22 inhibited anti-GM1 antibody activity in only 2 of 11 patients (80 and 86%).	G(M1) Ganglioside	28-31	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	4-7
7489364-0	1995	GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer"s disease.	G(M1) Ganglioside	0-15	amyloid beta precursor protein	Homo sapiens	44-50
7489364-3	1995	Here we report on the presence of membrane-bound A beta that tightly binds GM1 ganglioside.	G(M1) Ganglioside	75-90	amyloid beta precursor protein	Homo sapiens	49-55
7786888-15	1995	Our results suggest that calcium influx is a key element for both DNA-binding activity of AP-1 and cell proliferation induced by binding of the B subunit of cholera toxin to cell surface ganglioside GM1.	G(M1) Ganglioside	199-202	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94
7539142-7	1995	Furthermore, such tight association of GM1 with Trk appears to be specific, since a similar association was not observed with other growth factor receptors, such as low-affinity NGF receptor (p75NGR) and epidermal growth factor receptor (EGFR).	G(M1) Ganglioside	39-42	epidermal growth factor receptor	Rattus norvegicus	238-242
7779864-0	1995	Modulation by GM1 ganglioside of beta 1-adrenergic receptor-induced cyclic AMP formation in Sf9 cells.	G(M1) Ganglioside	14-29	adrenoceptor beta 1	Homo sapiens	33-59
7779864-7	1995	Binding studies with (-)-[3H]CGP12177 showed that preincubation with GM1 significantly reduced the affinity of antagonist binding to the beta 1-adrenergic receptor.	G(M1) Ganglioside	69-72	adrenoceptor beta 1	Homo sapiens	137-163
7779864-8	1995	These results suggest that GM1 or related ganglioside structure(s) may function as natural modulator(s) of the beta 1-adrenergic receptor.	G(M1) Ganglioside	27-30	adrenoceptor beta 1	Homo sapiens	111-137
7478679-1	1995	The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons.	G(M1) Ganglioside	156-171	protein kinase C, gamma	Rattus norvegicus	224-240
7478679-1	1995	The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons.	G(M1) Ganglioside	156-171	protein kinase C, gamma	Rattus norvegicus	242-245
7539142-0	1995	Ganglioside GM1 binds to the Trk protein and regulates receptor function.	G(M1) Ganglioside	12-15	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	29-32
7539142-1	1995	Several lines of evidence have suggested that ganglioside GM1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF), but its precise mechanism is yet to be elucidated.	G(M1) Ganglioside	58-61	nerve growth factor	Rattus norvegicus	119-138
7539142-1	1995	Several lines of evidence have suggested that ganglioside GM1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF), but its precise mechanism is yet to be elucidated.	G(M1) Ganglioside	58-61	nerve growth factor	Rattus norvegicus	140-143
7539142-2	1995	We report here that GM1 directly and tightly associates with Trk, the high-affinity tyrosine kinase-type receptor for NGF, and strongly enhances neurite outgrowth and neurofilament expression in rat PC12 cells elicited by a low dose of NGF that alone is insufficient to induce neuronal differentiation.	G(M1) Ganglioside	20-23	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	61-64
7539142-2	1995	We report here that GM1 directly and tightly associates with Trk, the high-affinity tyrosine kinase-type receptor for NGF, and strongly enhances neurite outgrowth and neurofilament expression in rat PC12 cells elicited by a low dose of NGF that alone is insufficient to induce neuronal differentiation.	G(M1) Ganglioside	20-23	nerve growth factor	Rattus norvegicus	118-121
7539142-2	1995	We report here that GM1 directly and tightly associates with Trk, the high-affinity tyrosine kinase-type receptor for NGF, and strongly enhances neurite outgrowth and neurofilament expression in rat PC12 cells elicited by a low dose of NGF that alone is insufficient to induce neuronal differentiation.	G(M1) Ganglioside	20-23	nerve growth factor	Rattus norvegicus	236-239
7539142-3	1995	The potentiation of NGF activity by GM1 appears to involve tyrosine-autophosphorylation of Trk, which contains intrinsic tyrosine kinase activity that has been localized to the cytoplasmic domain.	G(M1) Ganglioside	36-39	nerve growth factor	Rattus norvegicus	20-23
7539142-3	1995	The potentiation of NGF activity by GM1 appears to involve tyrosine-autophosphorylation of Trk, which contains intrinsic tyrosine kinase activity that has been localized to the cytoplasmic domain.	G(M1) Ganglioside	36-39	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	91-94
7539142-8	1995	Thus, these results strongly suggest that GM1 functions as a specific endogenous activator of NGF receptor function, and these enhanced effects appear to be due, at least in part, to tight association of GM1 with Trk.	G(M1) Ganglioside	42-45	nerve growth factor receptor	Rattus norvegicus	94-106
7539142-4	1995	In the presence of GM1 in culture medium, there is a > 3-fold increase in NGF-induced autophosphorylation of Trk as compared with NGF alone.	G(M1) Ganglioside	19-22	nerve growth factor	Rattus norvegicus	77-80
7539142-4	1995	In the presence of GM1 in culture medium, there is a > 3-fold increase in NGF-induced autophosphorylation of Trk as compared with NGF alone.	G(M1) Ganglioside	19-22	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	112-115
7539142-8	1995	Thus, these results strongly suggest that GM1 functions as a specific endogenous activator of NGF receptor function, and these enhanced effects appear to be due, at least in part, to tight association of GM1 with Trk.	G(M1) Ganglioside	42-45	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	213-216
7539142-4	1995	In the presence of GM1 in culture medium, there is a > 3-fold increase in NGF-induced autophosphorylation of Trk as compared with NGF alone.	G(M1) Ganglioside	19-22	nerve growth factor	Rattus norvegicus	133-136
7539142-5	1995	We also found that GM1 could directly enhance NGF-activated autophosphorylation of immunoprecipitated Trk in vitro.	G(M1) Ganglioside	19-22	nerve growth factor	Rattus norvegicus	46-49
7539142-8	1995	Thus, these results strongly suggest that GM1 functions as a specific endogenous activator of NGF receptor function, and these enhanced effects appear to be due, at least in part, to tight association of GM1 with Trk.	G(M1) Ganglioside	204-207	nerve growth factor receptor	Rattus norvegicus	94-106
7539142-5	1995	We also found that GM1 could directly enhance NGF-activated autophosphorylation of immunoprecipitated Trk in vitro.	G(M1) Ganglioside	19-22	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	102-105
7539142-8	1995	Thus, these results strongly suggest that GM1 functions as a specific endogenous activator of NGF receptor function, and these enhanced effects appear to be due, at least in part, to tight association of GM1 with Trk.	G(M1) Ganglioside	204-207	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	213-216
7539142-6	1995	Monosialoganglioside GM1, but not polysialogangliosides, is tightly associated with immunoprecipitated Trk.	G(M1) Ganglioside	0-24	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	103-106
7539142-7	1995	Furthermore, such tight association of GM1 with Trk appears to be specific, since a similar association was not observed with other growth factor receptors, such as low-affinity NGF receptor (p75NGR) and epidermal growth factor receptor (EGFR).	G(M1) Ganglioside	39-42	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	48-51
7861160-8	1995	In another set of experiments, it was found that the activities of the GalNAc-T and the enzyme that converts GM2 to GM1 [galactosyltransferase II (Gal T-II)] increased about threefold from birth to day 4 and then decreased to stabilize by day 6 in values that were similar to those at birth and about one-half those of ST-II.	G(M1) Ganglioside	116-119	beta-1,4-N-acetyl-galactosaminyl transferase 1	Rattus norvegicus	71-79
7650526-2	1995	In these experiments, the B subunit of cholera toxin (CT-B), which binds to GM1, was used to target an antibody response to GM1 in peripheral nerve.	G(M1) Ganglioside	76-79	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	54-58
7650526-2	1995	In these experiments, the B subunit of cholera toxin (CT-B), which binds to GM1, was used to target an antibody response to GM1 in peripheral nerve.	G(M1) Ganglioside	124-127	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	54-58
7620904-7	1995	Lectins with the highest degree of binding included cholera toxin B subunit (CTB), which binds primarily to the gangliosides GM1 and GD1b, phaseolus vulgaris erythroagglutinating lectin (PHA-E), which binds to a variety of cell adhesion molecules, and wheat germ agglutinin (WGA).	G(M1) Ganglioside	125-128	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	77-80
7789456-0	1995	Systemic administration of GM1 ganglioside increases choline acetyltransferase activity in the brain of aged rats.	G(M1) Ganglioside	27-42	choline O-acetyltransferase	Rattus norvegicus	53-78
7730449-0	1995	IgG anti-GM1 antibodies from patients with acute motor neuropathy are predominantly of the IgG1 and IgG3 subclasses.	G(M1) Ganglioside	9-12	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	100-104
7632320-8	1995	In GM1-treated rabbits the NMDA-induced decrease in Ca2+ concentrations in the dialyzates was not reduced significantly, whereas a 70% stimulation of 45Ca efflux was noted, with a concomitant 40% reduction of 6-keto-PG F1 alpha release.	G(M1) Ganglioside	3-6	carbonic anhydrase 2	Oryctolagus cuniculus	52-55
7852388-3	1995	Our findings indicate that GM1-promoted survival can be mediated in part by the Trk NGF receptor as well as by TrkB, and potentially by tyrosine kinase receptors for additional neurotrophic growth factors.	G(M1) Ganglioside	27-30	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	80-83
7852388-3	1995	Our findings indicate that GM1-promoted survival can be mediated in part by the Trk NGF receptor as well as by TrkB, and potentially by tyrosine kinase receptors for additional neurotrophic growth factors.	G(M1) Ganglioside	27-30	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	111-115
7852388-4	1995	Experiments employing K-252a, an inhibitor of Trk kinases, and PC12 cells overexpressing a dominant inhibitory form of Trk both indicate that a portion of the survival-promoting activity of GM1 is evoked by receptor dimerization and autophosphorylation.	G(M1) Ganglioside	190-193	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	46-49
7852388-4	1995	Experiments employing K-252a, an inhibitor of Trk kinases, and PC12 cells overexpressing a dominant inhibitory form of Trk both indicate that a portion of the survival-promoting activity of GM1 is evoked by receptor dimerization and autophosphorylation.	G(M1) Ganglioside	190-193	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	119-122
7852388-5	1995	In consonance with this we find that GM1 stimulates Trk tyrosine autophosphorylation and Trk-associated protein kinase activity.	G(M1) Ganglioside	37-40	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	52-55
7852388-5	1995	In consonance with this we find that GM1 stimulates Trk tyrosine autophosphorylation and Trk-associated protein kinase activity.	G(M1) Ganglioside	37-40	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	89-92
7853166-3	1995	via a minipump, with various doses of NGF or GM1 for a period of 7 days prevented the lesion-induced decline in nucleus basalis magnocellularis choline acetyltransferase (ChAT) activity in a dose-dependent manner.	G(M1) Ganglioside	45-48	choline O-acetyltransferase	Rattus norvegicus	144-169
7896755-1	1994	Three kinds of anti-GM1 monoclonal antibodies, AGM-1, -2, and -3, of the IgM class were produced by the immunization of BALB/c mice with ganglioside GM1 inserted into liposomes with Salmonella minnesota R595 lipopolysaccharides and fusion of the spleen cells with a mouse myeloma cell line.	G(M1) Ganglioside	20-23	phosphoglucomutase 3	Mus musculus	47-64
8569535-2	1995	High titers of endogenous IFN-gamma were detected in the extracts of the livers and spleens during 24 hr of the infection, reaching the peak at 8 hr, and the IFN-gamma production was reduced by in vivo administration of anti-NK 1.1 monoclonal antibody (MAb) or antibody against asialo GM1+ cells.	G(M1) Ganglioside	285-288	interferon gamma	Mus musculus	26-35
8569535-2	1995	High titers of endogenous IFN-gamma were detected in the extracts of the livers and spleens during 24 hr of the infection, reaching the peak at 8 hr, and the IFN-gamma production was reduced by in vivo administration of anti-NK 1.1 monoclonal antibody (MAb) or antibody against asialo GM1+ cells.	G(M1) Ganglioside	285-288	interferon gamma	Mus musculus	158-167
7996425-12	1994	In conclusion, GM1-induced elevation of behavioral supersensitivity cannot be explained by a direct interaction with the D2 dopamine receptor, but other mechanisms may be involved, such as the modification of second messenger pathways.	G(M1) Ganglioside	15-18	dopamine receptor D2	Rattus norvegicus	121-141
7957581-2	1994	Among the various gangliosides tested, only GM1 enhanced immunoglobulin (Ig) production and proliferation in the human plasma cell lines, IM-9 and AF-10, while other gangliosides (GM2, GM3, GD1a, GD1b, GD3, GT1b, and GQ1b) had no effect.	G(M1) Ganglioside	44-47	MLLT10 histone lysine methyltransferase DOT1L cofactor	Homo sapiens	147-152
7957581-4	1994	However, the enhancement of plasma cell responses by GM1 was specific and was not mediated by IL-6, since GM1 activity was blocked by anti-GM1 monoclonal antibody (mAb), but not by control IgM, anti-IL-6 Ab or the anti-IL-6 receptor mAb, PM1.	G(M1) Ganglioside	53-56	interleukin 6	Homo sapiens	199-203
7957581-4	1994	However, the enhancement of plasma cell responses by GM1 was specific and was not mediated by IL-6, since GM1 activity was blocked by anti-GM1 monoclonal antibody (mAb), but not by control IgM, anti-IL-6 Ab or the anti-IL-6 receptor mAb, PM1.	G(M1) Ganglioside	53-56	interleukin 6	Homo sapiens	199-203
7957581-4	1994	However, the enhancement of plasma cell responses by GM1 was specific and was not mediated by IL-6, since GM1 activity was blocked by anti-GM1 monoclonal antibody (mAb), but not by control IgM, anti-IL-6 Ab or the anti-IL-6 receptor mAb, PM1.	G(M1) Ganglioside	53-56	transmembrane protein 11	Homo sapiens	238-241
7850027-5	1994	In this study immunofluorescence flow cytometry shows that cholera toxin beta subunit (CT beta), which binds to the ganglioside GM1, induces a twofold increase in the number of DEV cells differentiating towards a neuronal pathway, as shown by the increased proportion and labelling intensity of cells stained by an anti-neurofilament antibody.	G(M1) Ganglioside	128-131	phosphate cytidylyltransferase 1B, choline	Homo sapiens	87-94
7531761-1	1994	A 79-year-old man with sensory dominant polyneuropathy, cerebellar ataxia, and palatal myoclonus had serum IgM M-protein that specifically bound to GM1, GD1b, and asialo-GM1.	G(M1) Ganglioside	148-151	myomesin 2	Homo sapiens	111-120
7531761-1	1994	A 79-year-old man with sensory dominant polyneuropathy, cerebellar ataxia, and palatal myoclonus had serum IgM M-protein that specifically bound to GM1, GD1b, and asialo-GM1.	G(M1) Ganglioside	170-173	myomesin 2	Homo sapiens	111-120
7927723-4	1994	Commercial, radiolabeled LPS as well as whole bacteria of strain ATCC 19660 also bound to asialo GM1.	G(M1) Ganglioside	97-100	toll-like receptor 4	Mus musculus	25-28
7827509-6	1994	Comparing amino acid composition, amino-terminal sequence, mass spectrum, pentamerisation, and GM1-binding, rCT-B is indistinguishable from natural CT-B produced by Vibrio cholerae.	G(M1) Ganglioside	95-98	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	108-113
7858413-5	1994	However, minor components of the gangliosides such as GM2 and GM1 emerged only in BL-6-beta m melanomas after treatment with IL-2.	G(M1) Ganglioside	62-65	interleukin 2	Mus musculus	125-129
7858413-6	1994	Local injection of IL-2 caused considerable infiltration of anti-asialo GM1-positive cells into the nests as well as the interstitials of BL-6-beta m melanomas.	G(M1) Ganglioside	72-75	interleukin 2	Mus musculus	19-23
7858413-7	1994	In contrast, in the BL-6 melanomas treated with IL-2, infiltration of the anti-asialo GM1-positive cells was hardly seen, although anti-Thy1,2 and anti-macrophage-positive cells were found to more or less the same extent as observed in BL-6-beta m melanomas.	G(M1) Ganglioside	86-89	interleukin 2	Mus musculus	48-52
7820065-0	1994	Ganglioside GM1 reduces ethanol induced phospholipase A2 activity in synaptosomal preparations from mice.	G(M1) Ganglioside	12-15	phospholipase A2, group IB, pancreas	Mus musculus	40-56
7820065-5	1994	The present study indicates that GM1 pretreatment both in vivo and in vitro reduced the EtOH-induced activation of PLA2 in synaptosomal preparations.	G(M1) Ganglioside	33-36	phospholipase A2, group IB, pancreas	Mus musculus	115-119
7827509-6	1994	Comparing amino acid composition, amino-terminal sequence, mass spectrum, pentamerisation, and GM1-binding, rCT-B is indistinguishable from natural CT-B produced by Vibrio cholerae.	G(M1) Ganglioside	95-98	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	109-113
7913944-8	1994	NK cells are likely to be a major source of the immunoregulatory IFN-gamma, because the effects of IL-12 on Th2 cytokine production were suppressed in mice treated with anti-asialo-GM1 Abs.	G(M1) Ganglioside	181-184	interferon gamma	Mus musculus	65-74
7846742-8	1994	The majority of metabolites had no effect on release of these analytes; however, GM1, at 5,000 micrograms/L resulted in a significant (p < 0.05) increase in ET-1, while GM9 at both 500 and 5,000 micrograms/L resulted in a significant (p < 0.01) decrease in PGI2 from mesangial cells.	G(M1) Ganglioside	81-84	endothelin-1	Oryctolagus cuniculus	160-164
8086501-6	1994	Upon submitting equal amounts of formylated CTB and site-specific succinylated CTB to a denaturation-renaturation cycle, hybrid pentamers were formed which in contrast to the parental compounds were able to bind GM1.	G(M1) Ganglioside	212-215	phosphate cytidylyltransferase 1B, choline	Homo sapiens	44-47
8086501-6	1994	Upon submitting equal amounts of formylated CTB and site-specific succinylated CTB to a denaturation-renaturation cycle, hybrid pentamers were formed which in contrast to the parental compounds were able to bind GM1.	G(M1) Ganglioside	212-215	phosphate cytidylyltransferase 1B, choline	Homo sapiens	79-82
8086501-7	1994	The affinity of hybrid CTB for GM1, as estimated by a competitive solid-phase radiobinding assay was unexpectedly high and only 2.5-fold lower than that of its native counterpart.	G(M1) Ganglioside	31-34	phosphate cytidylyltransferase 1B, choline	Homo sapiens	23-26
8086501-8	1994	The number of active binding sites on hybrid CTB was determined from: (i) titration with the oligosaccharide moiety of GM1 (oligo-GM1) and monitoring the reversal of the Trp fluorescence quenching by iodide ions and (ii) rapid gel filtration over a superdex HR column of a mixture of hybrid CTB and an excess of 3H-labeled oligo-GM1.	G(M1) Ganglioside	119-122	phosphate cytidylyltransferase 1B, choline	Homo sapiens	45-48
7913944-8	1994	NK cells are likely to be a major source of the immunoregulatory IFN-gamma, because the effects of IL-12 on Th2 cytokine production were suppressed in mice treated with anti-asialo-GM1 Abs.	G(M1) Ganglioside	181-184	heart and neural crest derivatives expressed 2	Mus musculus	108-111
7911785-5	1994	In vivo treatment with anti-asialo GM1 antiserum reduced NK cell activity and levels of IFN-gamma in serum but did not alter time to death.	G(M1) Ganglioside	35-38	interferon gamma	Mus musculus	88-97
7914399-10	1994	The cellular content of tyrosine hydroxylase was increased in the substantia nigra of the monkeys that received GM1 ganglioside injections.	G(M1) Ganglioside	112-127	tyrosine 3-monooxygenase	Macaca fascicularis	24-44
7914399-11	1994	The results show that the decreased expression of tyrosine hydroxylase found in nigral dopaminergic neurons after partial degeneration of the mesostriatal dopaminergic system is not influenced by levodopa treatment and is partially reversed by GM1 ganglioside administration.	G(M1) Ganglioside	244-259	tyrosine 3-monooxygenase	Macaca fascicularis	50-70
8144500-7	1994	This enzyme expressed in COS-7 cells exhibited transferase activity only toward the disaccharide moiety of Gal beta 1,3GalNAc of glycolipids as well as glycoproteins and oligosaccharides like ST3GalA.1, but showed a difference in acceptor substrate preference, i.e. asialo-GM1 and GM1 were much more suitable substrates for ST3GalA.2 than for ST3GalA.1.	G(M1) Ganglioside	273-276	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	192-201
7916448-0	1994	Blockade effect of nerve growth factor on GM1 ganglioside-induced activation of transglutaminase in superior cervical sympathetic ganglia excised from adult rat.	G(M1) Ganglioside	42-57	nerve growth factor	Rattus norvegicus	19-38
8068159-0	1994	Normal serum beta-galactosidase in juvenile GM1 gangliosidosis.	G(M1) Ganglioside	44-47	galactosidase beta 1	Homo sapiens	13-31
8200032-6	1994	The involvement of these two receptors was demonstrated in experiments using monoclonal antibodies to FcR and CD4, as well as monosialoganglioside GM1, a substance known to modulate surface CD4.	G(M1) Ganglioside	147-150	CD4 molecule	Homo sapiens	190-193
8200356-7	1994	Hydrolysis of liposomal lactosylceramide was compared with sap-B-stimulated hydrolysis of liposomal ganglioside GM1 by GM1-beta-galactosidase and sap-C-stimulated degradation of liposomal galactosylceramide by galactosylceramidase.	G(M1) Ganglioside	119-122	galactosidase beta 1	Homo sapiens	123-141
8200356-12	1994	GM1-beta-galactosidase was more active on these complexes than on glycolipids (GM1 and lactosylceramides) still residing in liposomal membranes.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	4-22
8163951-7	1994	The treatment of PM with IFN-gamma also results in secretion of IFN-gamma after 24-48 h. The upregulation of IFN-gamma expression is also found in PM from anti-asialo GM1-treated nude mice.	G(M1) Ganglioside	167-170	interferon gamma	Mus musculus	25-34
8163951-7	1994	The treatment of PM with IFN-gamma also results in secretion of IFN-gamma after 24-48 h. The upregulation of IFN-gamma expression is also found in PM from anti-asialo GM1-treated nude mice.	G(M1) Ganglioside	167-170	interferon gamma	Mus musculus	64-73
8163951-7	1994	The treatment of PM with IFN-gamma also results in secretion of IFN-gamma after 24-48 h. The upregulation of IFN-gamma expression is also found in PM from anti-asialo GM1-treated nude mice.	G(M1) Ganglioside	167-170	interferon gamma	Mus musculus	64-73
8144500-7	1994	This enzyme expressed in COS-7 cells exhibited transferase activity only toward the disaccharide moiety of Gal beta 1,3GalNAc of glycolipids as well as glycoproteins and oligosaccharides like ST3GalA.1, but showed a difference in acceptor substrate preference, i.e. asialo-GM1 and GM1 were much more suitable substrates for ST3GalA.2 than for ST3GalA.1.	G(M1) Ganglioside	281-284	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	192-201
7986393-6	1994	The number and morphologic change of SH-SY5Y cells were evaluated in the serum free medium added GM1 ganglioside with insulin or PDGF.	G(M1) Ganglioside	97-112	insulin	Homo sapiens	118-125
7511641-7	1994	Accordingly, tyrosine phosphorylation of PLC gamma-1 can be evidenced but only in Jurkat cells highly expressing GM1.	G(M1) Ganglioside	113-116	phospholipase C gamma 1	Homo sapiens	41-52
8021969-1	1994	We examined the binding of the gp120 envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV-1) to sulfatide (GalS), galactocerebroside (GalC), and GM1-ganglioside (GM1).	G(M1) Ganglioside	163-178	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	31-36
7511641-8	1994	GM1 stimulation results in an IL-2 production comparable to that obtained after CD3 activation.	G(M1) Ganglioside	0-3	interleukin 2	Homo sapiens	30-34
7511644-3	1994	Optimal proliferation of highly purified asialo GM1+ NK cells from the SCID spleen was observed in response to stimulation with IL-2 and PMA, together with anti-CD28 or L-B7+ cells.	G(M1) Ganglioside	48-51	interleukin 2	Mus musculus	128-132
7907633-4	1994	The IFN-gamma-inducing effect of IL-12 is partially blocked by pretreatment of mice with anti-asialo GM1 (anti-NK cell) Ab, but anti-asialo GM1 does not abrogate any of the other systemic actions of IL-12.	G(M1) Ganglioside	101-104	interferon gamma	Mus musculus	4-13
8021969-1	1994	We examined the binding of the gp120 envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV-1) to sulfatide (GalS), galactocerebroside (GalC), and GM1-ganglioside (GM1).	G(M1) Ganglioside	163-178	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	60-65
8021969-1	1994	We examined the binding of the gp120 envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV-1) to sulfatide (GalS), galactocerebroside (GalC), and GM1-ganglioside (GM1).	G(M1) Ganglioside	163-166	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	31-36
8021969-1	1994	We examined the binding of the gp120 envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV-1) to sulfatide (GalS), galactocerebroside (GalC), and GM1-ganglioside (GM1).	G(M1) Ganglioside	163-166	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	60-65
8110807-1	1994	The modulation by gangliosides GM1 and GD1a, and sulfatide (Sulf) of the activity of porcine pancreatic phospholipase A2 was studied with small unilamellar vesicles of dipalmitoylphosphatidylcholine (L-dpPC) and lipid monolayers of dilauroylphosphatidylcholine (L-dlPC).	G(M1) Ganglioside	31-34	phospholipase A2 group IB	Homo sapiens	104-120
7907638-9	1994	However, the combination of pretreatment with anti-asialo GM1 plus radiation, significantly increased the mean percentage of human CD3+ cells in the spleen to 40% within 2 weeks following injection of PBLs.	G(M1) Ganglioside	58-61	CD3 antigen, epsilon polypeptide	Mus musculus	131-134
7907638-10	1994	Human T cells positive for CD4, CD8, TcR alpha beta, and TcR gamma delta, and human NK and B cells were detected in the spleens of irradiated plus anti-asialo GM1 pretreated SCID mice.	G(M1) Ganglioside	159-162	CD4 molecule	Homo sapiens	27-30
8118871-1	1994	T cells made CD4- by ganglioside (GM1) treatment were cultured in antisense oligodeoxynucleotides complementary to mRNA for CD4.	G(M1) Ganglioside	34-37	CD4 molecule	Homo sapiens	13-16
7710670-8	1994	In young lesioned rats daily intraperitoneal administration of GM1 (30 mg/kg) for 21 days after surgery promoted both the recovery of choline acetyltransferase activity and passive avoidance performance.	G(M1) Ganglioside	63-66	choline O-acetyltransferase	Rattus norvegicus	134-159
8118871-4	1994	However, modulation of CD4 from the cell surface by either GM1 or antisense resulted in greater proliferation and enhanced DTH when challenged with recall antigen.	G(M1) Ganglioside	59-62	CD4 molecule	Homo sapiens	23-26
8003954-6	1994	The binding of GM1 to cholera toxin thus resembles a 2-fingered grip: the Gal(beta 1-3)GalNAc moiety representing the "forefinger" and the sialic acid representing the "thumb."	G(M1) Ganglioside	15-18	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	78-86
7710670-10	1994	Only when GM1 administration was started 3 days before the lesion, were a complete recovery in choline acetyltransferase activity in the contralateral cortex and a partial recovery in the ipsilateral cortex obtained.	G(M1) Ganglioside	10-13	choline O-acetyltransferase	Rattus norvegicus	95-120
7693577-1	1993	GM1 gangliosidosis and Morquio syndrome type B (MPS IVB) are inherited lyosomal storage disorders associated with deficiency of beta-galactosidase-A (beta GALA) activity.	G(M1) Ganglioside	0-3	galactosidase alpha	Homo sapiens	155-159
7693553-3	1993	The hybrid protein synthesized in Escherichia coli was found to maintain the ability of CTB to pentamerize, and to adhere to its cell receptor, the GM1 ganglioside.	G(M1) Ganglioside	148-163	phosphate cytidylyltransferase 1B, choline	Homo sapiens	88-91
8228800-4	1993	Vaccinated beta 2m-deficient mice, but not control heterozygotes, showed a five- to six-fold expansion in spleen cell number and approximately 40% of the splenocytes were found to express the NK markers NK1.1 and asialo GM1.	G(M1) Ganglioside	220-223	beta-2 microglobulin	Mus musculus	11-18
8228800-7	1993	More importantly, vaccine-induced immunity in beta 2m-deficient mice was completely abrogated by in vivo administration of antibody to NK1.1, asialo GM1, or IFN-gamma.	G(M1) Ganglioside	149-152	beta-2 microglobulin	Mus musculus	46-53
8278055-0	1993	Potentiation of nerve growth factor-induced alterations in cholinergic fibre length and presynaptic terminal size in cortex of lesioned rats by the monosialoganglioside GM1.	G(M1) Ganglioside	169-172	nerve growth factor	Rattus norvegicus	16-35
8278055-7	1993	Monosialoganglioside GM1 or nerve growth factor treatment equally attenuated deficits in nucleus basalis magnocellularis cell size and cortical choline acetyltransferase immunoreactive fibre length.	G(M1) Ganglioside	0-24	choline O-acetyltransferase	Rattus norvegicus	144-169
8278055-12	1993	However, exogenous nerve growth factor provoked a significant increase (35% above control values) in cortical cholinergic presynaptic terminal size which was even further augmented by concurrent GM1 treatment (69% above control values).	G(M1) Ganglioside	195-198	nerve growth factor	Rattus norvegicus	19-38
8263528-1	1994	Phosphorylation of the nervous system-specific protein GAP-43 in growth cones in vivo increases as the growth cones near their targets, at a time when the gangliosides GM1 and GD1a are being accumulated in the growth cone membrane, thus raising the possibility that the gangliosides could modulate GAP-43 behavior.	G(M1) Ganglioside	168-171	growth associated protein 43	Homo sapiens	55-61
8263528-2	1994	We used a subcellular fraction of intact isolated growth cones to show that both GM1 and GD1a affected the calcium-dependent posttranslational regulation of GAP-43 in several similar ways.	G(M1) Ganglioside	81-84	growth associated protein 43	Homo sapiens	157-163
8263528-6	1994	Finally, calcium-dependent proteolysis of GAP-43 was also stimulated by both GM1 and GD1a.	G(M1) Ganglioside	77-80	growth associated protein 43	Homo sapiens	42-48
8228272-1	1993	A simple and rapid assay for detection of antibodies against GM1 and other gangliosides (GM3, GM2, GD1a, GD1b, GT1b, GD3) is described.	G(M1) Ganglioside	61-64	GRDX	Homo sapiens	117-120
8373775-2	1993	The DSC thermograms exhibited by DMPC/GM1 vesicles, either in the presence or in the absence of GPA, are resolvable into two components.	G(M1) Ganglioside	38-41	glycophorin A (MNS blood group)	Homo sapiens	96-99
8239303-9	1993	GM1 treatment to aged rats was seen to potentiate the NGF-induced increase of ChAT activity in the striatum ipsilateral to the NGF infusion.	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	54-57
8239303-9	1993	GM1 treatment to aged rats was seen to potentiate the NGF-induced increase of ChAT activity in the striatum ipsilateral to the NGF infusion.	G(M1) Ganglioside	0-3	choline O-acetyltransferase	Rattus norvegicus	78-82
8239303-9	1993	GM1 treatment to aged rats was seen to potentiate the NGF-induced increase of ChAT activity in the striatum ipsilateral to the NGF infusion.	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	127-130
8239303-10	1993	Moreover, in the striatum contralateral to the NGF infusion, GM1 increased ChAT activity above the control values, whereas NGF treatment alone did not affect enzymatic activity.	G(M1) Ganglioside	61-64	nerve growth factor	Rattus norvegicus	47-50
8239303-10	1993	Moreover, in the striatum contralateral to the NGF infusion, GM1 increased ChAT activity above the control values, whereas NGF treatment alone did not affect enzymatic activity.	G(M1) Ganglioside	61-64	choline O-acetyltransferase	Rattus norvegicus	75-79
8373775-5	1993	At a given concentration of GM1 embedded in the vesicles, the proportion of the phase-separated peak is higher in the presence of GPA, suggesting that the glycoprotein enhances the tendency of GM1 to segregate.	G(M1) Ganglioside	28-31	glycophorin A (MNS blood group)	Homo sapiens	130-133
8373775-5	1993	At a given concentration of GM1 embedded in the vesicles, the proportion of the phase-separated peak is higher in the presence of GPA, suggesting that the glycoprotein enhances the tendency of GM1 to segregate.	G(M1) Ganglioside	193-196	glycophorin A (MNS blood group)	Homo sapiens	130-133
8373775-6	1993	Experiments investigating the thermotropic behavior of GPA show that the temperature of irreversible thermal unfolding of the glycoprotein inserted in DMPC vesicles, centered at 65.9 degrees C in the absence of GM1, is shifted to 57.6 degrees C when GM1 is present in the bilayer.	G(M1) Ganglioside	250-253	glycophorin A (MNS blood group)	Homo sapiens	55-58
8410149-10	1993	Both three-dimensional increases in spinal cord membrane-bound PKC and nociceptive behaviors (thermal hyperalgesia and spontaneous pain behaviors) in CCI rats were reliably reduced after three daily intrathecal treatments with 80 nmol GM1 ganglioside (a glycosphingolipid shown to prevent PKC translocation/activation), the first of which was given 1 h after sciatic nerve ligation.	G(M1) Ganglioside	235-250	protein kinase C, gamma	Rattus norvegicus	63-66
8264958-4	1993	More importantly, subthreshold amounts of BDNF were rendered efficacious in the presence of ganglioside GM1: loss of tyrosine hydroxylase positive cells was reduced from 80% to only 20%.	G(M1) Ganglioside	104-107	brain-derived neurotrophic factor	Rattus norvegicus	42-46
8261024-11	1993	Only lesioned subjects with transplants which were given sustained GM1 treatment (i.e., 10 days plus weekly injections for 4 weeks) showed significant attenuations of lesion-induced CAT and AChE depletions.	G(M1) Ganglioside	67-70	acetylcholinesterase	Rattus norvegicus	190-194
8360694-6	1993	Remarkably, GM1 was the only ganglioside where the proportion of LCB 20:1 was higher in the synaptosomal fraction than in the myelin fraction.	G(M1) Ganglioside	12-15	clathrin, light chain B	Rattus norvegicus	65-68
8410149-10	1993	Both three-dimensional increases in spinal cord membrane-bound PKC and nociceptive behaviors (thermal hyperalgesia and spontaneous pain behaviors) in CCI rats were reliably reduced after three daily intrathecal treatments with 80 nmol GM1 ganglioside (a glycosphingolipid shown to prevent PKC translocation/activation), the first of which was given 1 h after sciatic nerve ligation.	G(M1) Ganglioside	235-250	protein kinase C, gamma	Rattus norvegicus	289-292
8410149-14	1993	Similar correlations were observed between decreases in levels of membrane-bound PKC in the spinal cord dorsal horn and the attenuation of nociceptive behaviors in CCI rats after three daily intrathecal treatments with GM1 ganglioside.	G(M1) Ganglioside	219-234	protein kinase C, gamma	Rattus norvegicus	81-84
7685813-3	1993	The GM1 treatment caused statistically significant attenuation of GFAP increment in all hippocampal parts.	G(M1) Ganglioside	4-7	glial fibrillary acidic protein	Rattus norvegicus	66-70
8473744-4	1993	Spleen cells depleted of cells bearing NK1.1, asialo GM1, Thy 1.2, or CD5 resulted in a significant reduction in IFN-gamma production after stimulation with S. typhimurium.	G(M1) Ganglioside	53-56	interferon gamma	Mus musculus	113-122
8101400-1	1993	Dendritic-shaped cells (Thy-1+DC) characterized by the surface phenotype of Thy-1+, asialo GM1+, Ia- are reported to exist exclusively in mice.	G(M1) Ganglioside	91-95	thymus cell antigen 1, theta	Mus musculus	24-29
8410057-2	1993	In addition, a subset of patients with neuroborreliosis (29%) and syphilis (59%) had IgM reactivity to gangliosides with a Gal(beta 1-3) GalNac terminal sequence (GM1, GD1b, and asialo GM1).	G(M1) Ganglioside	163-166	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	127-135
8410057-2	1993	In addition, a subset of patients with neuroborreliosis (29%) and syphilis (59%) had IgM reactivity to gangliosides with a Gal(beta 1-3) GalNac terminal sequence (GM1, GD1b, and asialo GM1).	G(M1) Ganglioside	185-188	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	127-135
8103682-1	1993	By means of light and confocal laser microscopical analysis of choleratoxin (CT) binding sites indicating the localization of the ganglioside GM1, evidence has been obtained for the presence of ganglioside GM1 in discrete nerve terminals, some of them identified by synapsin-1 immunoreactivity (IR), with a focal distribution in the nerve terminal membrane.	G(M1) Ganglioside	206-209	synapsin I	Rattus norvegicus	266-276
8103682-2	1993	Double immunolabelling studies demonstrate that GM1 positive nerve terminals are associated with tyrosine hydroxylase/fibroblast growth factor-2 (TH/FGF-2) immunoreactive dopamine (DA) perikarya in the zona compacta of the rat substantia nigra.	G(M1) Ganglioside	48-51	fibroblast growth factor 2	Rattus norvegicus	149-154
8103682-3	1993	It is suggested that GM1 may be released from these terminals to become incorporated into the nerve cell membrane of the FGF-2-containing DA nigral nerve cells, where they may enhance the activity of neurotrophic factor receptors such as those for FGF-2.	G(M1) Ganglioside	21-24	fibroblast growth factor 2	Rattus norvegicus	121-126
8103682-3	1993	It is suggested that GM1 may be released from these terminals to become incorporated into the nerve cell membrane of the FGF-2-containing DA nigral nerve cells, where they may enhance the activity of neurotrophic factor receptors such as those for FGF-2.	G(M1) Ganglioside	21-24	fibroblast growth factor 2	Rattus norvegicus	248-253
8473744-5	1993	In contrast, Con A-induced IFN-gamma production was only slightly reduced after depletion of NK1.1- or asialo GM1-bearing cells.	G(M1) Ganglioside	110-113	interferon gamma	Mus musculus	27-36
8395254-7	1993	PGD2 binding activity was increased by GD1a and GQ1b and decreased by GM1 and GT1a, while PGE2 binding activity was increased by GQ1b and galactocerebroside.	G(M1) Ganglioside	70-73	prostaglandin D2 synthase	Homo sapiens	0-4
8455041-1	1993	Exogenous gangliosides, especially ganglioside GM1 (GM1), seem to potentiate the action of nerve growth factor (NGF).	G(M1) Ganglioside	35-50	nerve growth factor	Rattus norvegicus	91-110
8455041-1	1993	Exogenous gangliosides, especially ganglioside GM1 (GM1), seem to potentiate the action of nerve growth factor (NGF).	G(M1) Ganglioside	35-50	nerve growth factor	Rattus norvegicus	112-115
8455041-1	1993	Exogenous gangliosides, especially ganglioside GM1 (GM1), seem to potentiate the action of nerve growth factor (NGF).	G(M1) Ganglioside	47-50	nerve growth factor	Rattus norvegicus	91-110
8455041-1	1993	Exogenous gangliosides, especially ganglioside GM1 (GM1), seem to potentiate the action of nerve growth factor (NGF).	G(M1) Ganglioside	47-50	nerve growth factor	Rattus norvegicus	112-115
8455041-2	1993	We have examined the possible regulation of the NGF signaling pathway in PC12 cells by the B subunit of cholera toxin (CTB), which binds to endogenous GM1 specifically and with a high affinity.	G(M1) Ganglioside	151-154	nerve growth factor	Rattus norvegicus	48-51
8455041-2	1993	We have examined the possible regulation of the NGF signaling pathway in PC12 cells by the B subunit of cholera toxin (CTB), which binds to endogenous GM1 specifically and with a high affinity.	G(M1) Ganglioside	151-154	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	119-122
8455041-7	1993	These results strongly suggest that the binding of cell surface GM1 by CTB modulates the pathway of intracellular signaling initiated by NGF and that the association of CTB with a cytoskeletal component is essential for these effects.	G(M1) Ganglioside	64-67	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	71-74
8455041-7	1993	These results strongly suggest that the binding of cell surface GM1 by CTB modulates the pathway of intracellular signaling initiated by NGF and that the association of CTB with a cytoskeletal component is essential for these effects.	G(M1) Ganglioside	64-67	nerve growth factor	Rattus norvegicus	137-140
8462156-10	1993	Immunoperoxidase stains demonstrated asialo GM1 ganglioside antibody-positive, granular lymphocytes to be much more frequent in myocardium of IL-2-treated rats than in that of control rats.	G(M1) Ganglioside	44-47	interleukin 2	Rattus norvegicus	142-146
8388365-4	1993	The fusion protein (t-gD-LTB), consisting of t-gD and LTB, induced the responses more efficiently than did co-administration of t-gD and LTB, although GM1 ganglioside binding activity was significantly reduced in t-gD-LTB.	G(M1) Ganglioside	151-166	lymphotoxin beta	Homo sapiens	25-28
8466487-0	1993	The monosialoganglioside GM1 induces internalisation and degradation of the CD4 antigen in U937 cells: evidence for a novel mechanism of CD4 down-modulation in a p56lck-negative cell line, which is independent of protein kinase C activation.	G(M1) Ganglioside	25-28	CD4 molecule	Homo sapiens	76-79
8466487-0	1993	The monosialoganglioside GM1 induces internalisation and degradation of the CD4 antigen in U937 cells: evidence for a novel mechanism of CD4 down-modulation in a p56lck-negative cell line, which is independent of protein kinase C activation.	G(M1) Ganglioside	25-28	CD4 molecule	Homo sapiens	137-140
8466487-0	1993	The monosialoganglioside GM1 induces internalisation and degradation of the CD4 antigen in U937 cells: evidence for a novel mechanism of CD4 down-modulation in a p56lck-negative cell line, which is independent of protein kinase C activation.	G(M1) Ganglioside	25-28	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	162-168
8466487-7	1993	The findings presented in this paper show that GM1 induces internalisation and the eventual degradation of the CD4 Ag also in the monocytic cell line U937.	G(M1) Ganglioside	47-50	CD4 molecule	Homo sapiens	111-114
21573567-9	1993	Effector cells, when treated with either OX-8 or SH-34 (anti-asialo-GM1) monoclonals and complement, lost the cytotoxic activity against AK-5 cells suggesting the role for OX-8+ NK cells in the tumor regression.	G(M1) Ganglioside	68-71	adenylate kinase 5	Mus musculus	137-141
8473022-4	1993	Administration of anti-asialo GM1 antibody abolished the NK cell activity in both normal and TNF-alpha-injected mice, but had no effect on the enteropathy caused by TNF-alpha.	G(M1) Ganglioside	30-33	eiger	Drosophila melanogaster	93-102
7678256-5	1993	GM1 treatment blocked binding of several mAbs which recognize epitopes located within the first two NH2-terminal domains of CD4 and did not induce CD4 down-modulation if MOLT-3 cells were preincubated with the OKT4A or the OKT4 mAbs.	G(M1) Ganglioside	0-3	CD4 molecule	Homo sapiens	124-127
7678256-0	1993	Mechanism of action of the monosialoganglioside GM1 as a modulator of CD4 expression.	G(M1) Ganglioside	48-51	CD4 molecule	Homo sapiens	70-73
7678256-2	1993	Analyzing the mechanisms underlying the capability of the monosialoganglioside GM1 to induce CD4 modulation we observed that GM1 has a dual effect on the CD4 molecule.	G(M1) Ganglioside	79-82	CD4 molecule	Homo sapiens	93-96
7678256-6	1993	Immunoprecipitation studies with [35S]methionine-labeled MOLT-3 cells showed that GM1-induced CD4 down-modulation was accompanied by CD4 degradation, and this was preceded by dissociation of p56lck from CD4.	G(M1) Ganglioside	82-85	CD4 molecule	Homo sapiens	94-97
7678256-2	1993	Analyzing the mechanisms underlying the capability of the monosialoganglioside GM1 to induce CD4 modulation we observed that GM1 has a dual effect on the CD4 molecule.	G(M1) Ganglioside	79-82	CD4 molecule	Homo sapiens	154-157
7678256-2	1993	Analyzing the mechanisms underlying the capability of the monosialoganglioside GM1 to induce CD4 modulation we observed that GM1 has a dual effect on the CD4 molecule.	G(M1) Ganglioside	125-128	CD4 molecule	Homo sapiens	93-96
7678256-2	1993	Analyzing the mechanisms underlying the capability of the monosialoganglioside GM1 to induce CD4 modulation we observed that GM1 has a dual effect on the CD4 molecule.	G(M1) Ganglioside	125-128	CD4 molecule	Homo sapiens	154-157
7678256-3	1993	GM1 treatment of the lymphoma cell line MOLT-3 and CD4-transfected HeLa cells for times shorter than 30 min prevented binding of monoclonal antibodies (mAbs) recognizing epitopes located within the first NH2-terminal domains of CD4, but not of the OKT4 mAb, which binds to the region of CD4 proximal to the transmembrane domain.	G(M1) Ganglioside	0-3	CD4 molecule	Homo sapiens	51-54
7678256-3	1993	GM1 treatment of the lymphoma cell line MOLT-3 and CD4-transfected HeLa cells for times shorter than 30 min prevented binding of monoclonal antibodies (mAbs) recognizing epitopes located within the first NH2-terminal domains of CD4, but not of the OKT4 mAb, which binds to the region of CD4 proximal to the transmembrane domain.	G(M1) Ganglioside	0-3	CD4 molecule	Homo sapiens	228-231
8094324-0	1993	Basic fibroblast growth factor modulates sensitivity of cultured hippocampal pyramidal neurons to glutamate cytotoxicity: interaction with ganglioside GM1.	G(M1) Ganglioside	139-154	fibroblast growth factor 2	Rattus norvegicus	0-30
7678256-6	1993	Immunoprecipitation studies with [35S]methionine-labeled MOLT-3 cells showed that GM1-induced CD4 down-modulation was accompanied by CD4 degradation, and this was preceded by dissociation of p56lck from CD4.	G(M1) Ganglioside	82-85	CD4 molecule	Homo sapiens	133-136
7678256-6	1993	Immunoprecipitation studies with [35S]methionine-labeled MOLT-3 cells showed that GM1-induced CD4 down-modulation was accompanied by CD4 degradation, and this was preceded by dissociation of p56lck from CD4.	G(M1) Ganglioside	82-85	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	191-197
7678256-6	1993	Immunoprecipitation studies with [35S]methionine-labeled MOLT-3 cells showed that GM1-induced CD4 down-modulation was accompanied by CD4 degradation, and this was preceded by dissociation of p56lck from CD4.	G(M1) Ganglioside	82-85	CD4 molecule	Homo sapiens	133-136
7678256-7	1993	GM1-induced CD4 down-modulation, dissociation of p56lck from CD4, and CD4 degradation were unaffected by staurosporine, which, on the contrary, blocked these events in response to phorbol 12-myristate 13-acetate.	G(M1) Ganglioside	0-3	CD4 molecule	Homo sapiens	12-15
7678256-3	1993	GM1 treatment of the lymphoma cell line MOLT-3 and CD4-transfected HeLa cells for times shorter than 30 min prevented binding of monoclonal antibodies (mAbs) recognizing epitopes located within the first NH2-terminal domains of CD4, but not of the OKT4 mAb, which binds to the region of CD4 proximal to the transmembrane domain.	G(M1) Ganglioside	0-3	CD4 molecule	Homo sapiens	228-231
7678256-7	1993	GM1-induced CD4 down-modulation, dissociation of p56lck from CD4, and CD4 degradation were unaffected by staurosporine, which, on the contrary, blocked these events in response to phorbol 12-myristate 13-acetate.	G(M1) Ganglioside	0-3	CD4 molecule	Homo sapiens	61-64
7678256-7	1993	GM1-induced CD4 down-modulation, dissociation of p56lck from CD4, and CD4 degradation were unaffected by staurosporine, which, on the contrary, blocked these events in response to phorbol 12-myristate 13-acetate.	G(M1) Ganglioside	0-3	CD4 molecule	Homo sapiens	61-64
7678256-8	1993	These observations demonstrate that the first action of GM1 is to mask epitopes located within the first two NH2-terminal domains; then, GM1 triggers protein kinase C-independent signals which cause p56lck dissociation from CD4 and the delivery of the molecule to an intracellular compartment where it is eventually degraded.	G(M1) Ganglioside	56-59	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	199-205
7678256-8	1993	These observations demonstrate that the first action of GM1 is to mask epitopes located within the first two NH2-terminal domains; then, GM1 triggers protein kinase C-independent signals which cause p56lck dissociation from CD4 and the delivery of the molecule to an intracellular compartment where it is eventually degraded.	G(M1) Ganglioside	56-59	CD4 molecule	Homo sapiens	224-227
7678256-8	1993	These observations demonstrate that the first action of GM1 is to mask epitopes located within the first two NH2-terminal domains; then, GM1 triggers protein kinase C-independent signals which cause p56lck dissociation from CD4 and the delivery of the molecule to an intracellular compartment where it is eventually degraded.	G(M1) Ganglioside	137-140	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	199-205
7678256-8	1993	These observations demonstrate that the first action of GM1 is to mask epitopes located within the first two NH2-terminal domains; then, GM1 triggers protein kinase C-independent signals which cause p56lck dissociation from CD4 and the delivery of the molecule to an intracellular compartment where it is eventually degraded.	G(M1) Ganglioside	137-140	CD4 molecule	Homo sapiens	224-227
1454804-5	1992	Prosaposin also stimulated ganglioside GM1 beta-galactosidase more than mature saposins.	G(M1) Ganglioside	39-42	prosaposin	Homo sapiens	0-10
8106089-0	1993	Ganglioside (GM1) distinguishes the effects of CD4 on signal transduction through the TCR/CD3 complex in human lymphocytes.	G(M1) Ganglioside	13-16	CD4 molecule	Homo sapiens	47-50
8106089-1	1993	Ganglioside (GM1) modulation of CD4 off the surface of T lymphocytes defined functions of the CD4 molecule during signal transduction through the T cell receptor (TCR)/CD3 complex.	G(M1) Ganglioside	13-16	CD4 molecule	Homo sapiens	32-35
8106089-1	1993	Ganglioside (GM1) modulation of CD4 off the surface of T lymphocytes defined functions of the CD4 molecule during signal transduction through the T cell receptor (TCR)/CD3 complex.	G(M1) Ganglioside	13-16	CD4 molecule	Homo sapiens	94-97
8106089-5	1993	GM1-modulation of CD4 from the cell surface blocked all aspects of the augmented signaling imparted by CD4 co-modulation with CD3.	G(M1) Ganglioside	0-3	CD4 molecule	Homo sapiens	18-21
8106089-5	1993	GM1-modulation of CD4 from the cell surface blocked all aspects of the augmented signaling imparted by CD4 co-modulation with CD3.	G(M1) Ganglioside	0-3	CD4 molecule	Homo sapiens	103-106
1468126-5	1992	But cholera toxin B subunit (CTB) specifically clustered GM1 and enhanced the transfer efficiency.	G(M1) Ganglioside	57-60	phosphate cytidylyltransferase 1B, choline	Homo sapiens	4-27
1468126-5	1992	But cholera toxin B subunit (CTB) specifically clustered GM1 and enhanced the transfer efficiency.	G(M1) Ganglioside	57-60	phosphate cytidylyltransferase 1B, choline	Homo sapiens	29-32
1577868-4	1992	However, the presence of GM1 (12.5-100 micrograms/ml) in the co-culture was associated with a potentiation of NCAM and N-cadherin-dependent neurite outgrowth.	G(M1) Ganglioside	25-28	neural cell adhesion molecule 1	Rattus norvegicus	110-114
1497620-2	1992	GM1 ganglioside beta-galactosidase (beta-Gal) is deficient in the autosomal recessive disorder GM1 gangliosidosis.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	16-34
1497620-2	1992	GM1 ganglioside beta-galactosidase (beta-Gal) is deficient in the autosomal recessive disorder GM1 gangliosidosis.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	36-44
1320885-0	1992	Effect of GM1-ganglioside on gastric mucosal epidermal growth factor and platelet-derived growth factor receptor expression.	G(M1) Ganglioside	10-25	epidermal growth factor like 1	Rattus norvegicus	45-68
1320885-0	1992	Effect of GM1-ganglioside on gastric mucosal epidermal growth factor and platelet-derived growth factor receptor expression.	G(M1) Ganglioside	10-25	myotrophin	Rattus norvegicus	55-68
1320885-1	1992	The effect of intragastric administration of GM1-ganglioside on the expression of gastric mucosal epidermal growth factor (EGF) and platelet derived growth factor (PDGF) receptors was investigated.	G(M1) Ganglioside	45-60	epidermal growth factor like 1	Rattus norvegicus	98-121
1320885-1	1992	The effect of intragastric administration of GM1-ganglioside on the expression of gastric mucosal epidermal growth factor (EGF) and platelet derived growth factor (PDGF) receptors was investigated.	G(M1) Ganglioside	45-60	epidermal growth factor like 1	Rattus norvegicus	123-126
1320885-1	1992	The effect of intragastric administration of GM1-ganglioside on the expression of gastric mucosal epidermal growth factor (EGF) and platelet derived growth factor (PDGF) receptors was investigated.	G(M1) Ganglioside	45-60	myotrophin	Rattus norvegicus	108-121
1436638-1	1992	Combined actions of GM1 ganglioside molecules and Ca2+ ions on long-term potentiation (LTP) of the hippocampal CA1 synapses were examined in slice preparations.	G(M1) Ganglioside	20-35	carbonic anhydrase 1	Rattus norvegicus	111-114
1436638-4	1992	Exogenous GM1 treatment not only antagonized LTP suppression caused by low Ca2+ (1.0 microM) in the perfusion medium, but also amplified LTP at high Ca2+ (5.0 microM) condition.	G(M1) Ganglioside	10-13	carbonic anhydrase 2	Rattus norvegicus	75-78
1436638-4	1992	Exogenous GM1 treatment not only antagonized LTP suppression caused by low Ca2+ (1.0 microM) in the perfusion medium, but also amplified LTP at high Ca2+ (5.0 microM) condition.	G(M1) Ganglioside	10-13	carbonic anhydrase 2	Rattus norvegicus	149-152
1577868-4	1992	However, the presence of GM1 (12.5-100 micrograms/ml) in the co-culture was associated with a potentiation of NCAM and N-cadherin-dependent neurite outgrowth.	G(M1) Ganglioside	25-28	cadherin 2	Rattus norvegicus	119-129
1577868-5	1992	Treatment of PC12 cells with GM1 (100 micrograms/ml) for 90 min led to trypsin-stable increases in both beta-cholera toxin binding to PC12 cells and an enhanced neurite outgrowth response to N-cadherin.	G(M1) Ganglioside	29-32	cadherin 2	Rattus norvegicus	191-201
1543718-1	1992	Galactosylceramide (GalCer) and the ganglioside, GM1, were 2H-labelled at C-6 (the hydroxymethyl moiety) of their single terminal galactosyl residues.	G(M1) Ganglioside	49-52	complement C6	Homo sapiens	74-77
1371788-4	1992	Looking at highly purified gangliosides, GD3, GD1a, GM3, GM2, and GM1 were all effective in reducing TNF production in PBMC, and in Mono Mac 6 by factor 10 to 50.	G(M1) Ganglioside	66-69	tumor necrosis factor	Homo sapiens	101-104
1730485-4	1992	Endogenous TNF production was suppressed by in vivo administration of anti-CD4 monoclonal antibody (MAb) or anti-asialo GM1 antibody but not by anti-CD8 MAb, whereas none of these antibodies suppressed endogenous IL-6 production.	G(M1) Ganglioside	120-123	tumor necrosis factor	Mus musculus	11-14
1309663-4	1992	The relevance of the negative charge steric effect is suggested by the finding that phosphatidylinositol phosphate (PIP) and trisialoganglioside (GT1) are less effective than phosphatidylinositol (PI) and monosialoganglioside (GM1), respectively, in retarding liposome clearance.	G(M1) Ganglioside	227-230	retinoic acid induced 1	Mus musculus	146-149
1817798-4	1991	The IgM M-protein in a case with motor dominant neuropathy bound to GM1, GD1b, GM2 but not to GA1.	G(M1) Ganglioside	68-71	myomesin 2	Homo sapiens	8-17
1375956-7	1992	In vivo activated effectors when incubated with anti-asialo-GM1 antibody plus complement lost completely their ability to lyse YAC-1 targets.	G(M1) Ganglioside	60-63	ADP-ribosyltransferase 1	Mus musculus	127-132
21551889-6	1992	The levels of the neuronal markers NCAM, D3 and synaptophysin showed significantly less decline in injured rats treated 7 days after the lesions with transplants or with daily injections of 30 mg/kg GM1.	G(M1) Ganglioside	199-202	neural cell adhesion molecule 1	Rattus norvegicus	35-39
21551889-6	1992	The levels of the neuronal markers NCAM, D3 and synaptophysin showed significantly less decline in injured rats treated 7 days after the lesions with transplants or with daily injections of 30 mg/kg GM1.	G(M1) Ganglioside	199-202	synaptophysin	Rattus norvegicus	48-61
21551889-7	1992	The decrease respectively constituted 23 (NCAM), 31 (D3) and 41% (synaptophysin) in rats with transplants and 23 (NCAM), 16 (D3) and 28% (synaptophysin) in rats treated with GM1.	G(M1) Ganglioside	174-177	synaptophysin	Rattus norvegicus	66-79
21551889-7	1992	The decrease respectively constituted 23 (NCAM), 31 (D3) and 41% (synaptophysin) in rats with transplants and 23 (NCAM), 16 (D3) and 28% (synaptophysin) in rats treated with GM1.	G(M1) Ganglioside	174-177	synaptophysin	Rattus norvegicus	138-151
1655824-7	1991	The beta-endorphin-responsive immune cells were shown to be a minor fraction of the small race T-lymphocyte population that bear the asialo-GM1 marker.	G(M1) Ganglioside	140-143	pro-opiomelanocortin-alpha	Mus musculus	4-18
1915720-3	1991	Newborn rats subjected to brain damage by NMDA and contemporaneously treated subcutaneously with GM1 showed significantly reduced (i) loss in hemispheric weight, (ii) loss in tissue choline acetyltransferase activity, and (iii) morphological damage in various brain areas.	G(M1) Ganglioside	97-100	choline O-acetyltransferase	Rattus norvegicus	182-207
1993186-1	1991	The ability of phospholipase A2 from porcine pancreas to degrade all of the available dilauroylphosphatidylcholine in mixed monolayers with galactocerebroside, sulfatide, or ganglioside GM1 was investigated at different constant surface pressures.	G(M1) Ganglioside	174-189	phospholipase A2 group IB	Homo sapiens	15-31
1919594-4	1991	In some storage diseases (GM1 and GM2 gangliosidosis), GAD-immunoreactive spheroids were a common occurrence in many brain regions, whereas in other disorders these structures were more limited in distribution (alpha-mannosidosis), or were absent (mucopolysaccharidosis type I).	G(M1) Ganglioside	26-29	glutamate decarboxylase 1	Homo sapiens	55-58
1943708-4	1991	Amino acid substitutions that caused decreased binding of mutant CT-B to ganglioside GM1 and abolished toxicity included negatively charged or large hydrophobic residues for Gly-33 and negatively or positively charged residues for Trp-88.	G(M1) Ganglioside	85-88	phosphate cytidylyltransferase 1B, choline	Homo sapiens	65-69
1676513-0	1991	Stimulation of a Ca(2+)-dependent protein kinase by GM1 ganglioside in nerve growth factor-treated PC12 cells.	G(M1) Ganglioside	52-67	nerve growth factor	Rattus norvegicus	71-90
1676513-3	1991	In the presence of NGF, exogenous GM1 (1-10 microM) increased 32P incorporation into TyrOHase phosphopeptide T2, a Ca2+/calmodulin-dependent protein kinase substrate whose phosphorylation is not normally affected by NGF treatment.	G(M1) Ganglioside	34-37	nerve growth factor	Rattus norvegicus	19-22
1676513-3	1991	In the presence of NGF, exogenous GM1 (1-10 microM) increased 32P incorporation into TyrOHase phosphopeptide T2, a Ca2+/calmodulin-dependent protein kinase substrate whose phosphorylation is not normally affected by NGF treatment.	G(M1) Ganglioside	34-37	nerve growth factor	Rattus norvegicus	216-219
1676513-7	1991	These results suggest that the stimulatory effects of exogenous GM1 ganglioside on NGF actions may be due to its ability to potentiate a Ca(2+)-dependent signaling pathway.	G(M1) Ganglioside	64-79	nerve growth factor	Rattus norvegicus	83-86
2000404-2	1991	Gangliosides copurified with human and porcine TSH-R migrated between monosialoganglioside GM1 and disialoganglioside GD1a.	G(M1) Ganglioside	91-94	thyroid stimulating hormone receptor	Homo sapiens	47-52
2000404-5	1991	These findings indicate that the human TSH-R contains ganglioside that belongs to the galactosyl(beta 1----3)-N-acetylgalactosaminyl (beta 1----4)-[N-acetylneuraminyl(alpha 2----3)]galactosyl(beta 1----4) glucosyl(beta 1----1)ceramide (GM1) family.	G(M1) Ganglioside	236-239	thyroid stimulating hormone receptor	Homo sapiens	39-44
2128304-4	1990	In vivo depletion of asialo GM1+ (AGM1+) cells prevented production of IFN-gamma through 16 h of culture with SEA, but permitted a modest IFN-gamma response at 20 h that was similar in magnitude in both sexes.	G(M1) Ganglioside	28-31	phosphoglucomutase 3	Mus musculus	34-38
1671080-4	1991	The antitumor action of IL-1/IL-2 treatment was abolished or markedly reduced in mice treated with antibodies to CD4 or CD8 antigens, whereas antibodies to asialo-GM1 were ineffective.	G(M1) Ganglioside	163-166	interleukin 1 complex	Mus musculus	24-28
1671080-4	1991	The antitumor action of IL-1/IL-2 treatment was abolished or markedly reduced in mice treated with antibodies to CD4 or CD8 antigens, whereas antibodies to asialo-GM1 were ineffective.	G(M1) Ganglioside	163-166	interleukin 2	Mus musculus	29-33
1767631-1	1991	Antibodies to GM1 or Gal(beta 1-3)GalNAc are associated with motor or sensorimotor neuropathy and with motor neuron disease.	G(M1) Ganglioside	14-17	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	25-33
2021961-8	1991	A significant increase in asialo GM1-positive cells and IL-2-receptor-positive cells was detected in the group treated with IL-2 plus cimetidine in comparison with the PBS and IL-2 control groups.	G(M1) Ganglioside	33-36	interleukin 2	Mus musculus	124-128
2021961-8	1991	A significant increase in asialo GM1-positive cells and IL-2-receptor-positive cells was detected in the group treated with IL-2 plus cimetidine in comparison with the PBS and IL-2 control groups.	G(M1) Ganglioside	33-36	interleukin 2	Mus musculus	124-128
1806363-2	1991	This fraction was distinct from those stimulating the hydrolysis of galactose from GM1 ganglioside by beta-galactosidase and the hydrolysis of N-acetylgalactosamine from GM2 ganglioside by hexosaminidase A.	G(M1) Ganglioside	83-98	galactosidase beta 1	Homo sapiens	102-120
2230813-8	1990	Administration of GM1 blocks completely the appearance of PKM, a result suggesting that PKC down-regulation and PKM activity elevation are intimately associated events and that both are regulated by GM1 ganglioside.	G(M1) Ganglioside	18-21	pyruvate kinase M1/2	Rattus norvegicus	58-61
2230813-8	1990	Administration of GM1 blocks completely the appearance of PKM, a result suggesting that PKC down-regulation and PKM activity elevation are intimately associated events and that both are regulated by GM1 ganglioside.	G(M1) Ganglioside	18-21	pyruvate kinase M1/2	Rattus norvegicus	112-115
2230813-8	1990	Administration of GM1 blocks completely the appearance of PKM, a result suggesting that PKC down-regulation and PKM activity elevation are intimately associated events and that both are regulated by GM1 ganglioside.	G(M1) Ganglioside	199-214	pyruvate kinase M1/2	Rattus norvegicus	58-61
1846542-1	1991	The B subunit of cholera toxin, which binds to ganglioside GM1, enhanced DNA synthesis in rat hepatocytes in primary culture induced by insulin and/or epidermal growth factor.	G(M1) Ganglioside	47-62	epidermal growth factor like 1	Rattus norvegicus	151-174
2128304-4	1990	In vivo depletion of asialo GM1+ (AGM1+) cells prevented production of IFN-gamma through 16 h of culture with SEA, but permitted a modest IFN-gamma response at 20 h that was similar in magnitude in both sexes.	G(M1) Ganglioside	28-31	interferon gamma	Mus musculus	71-80
2262006-0	1990	Purification and characterization of CMP-NeuAc:GM1 (Gal beta 1-4GalNAc) alpha 2-3 sialyltransferase from rat brain.	G(M1) Ganglioside	47-50	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Rattus norvegicus	52-99
2121675-7	1990	This antiproliferative effect of IL-1 beta in combination with nHuTNF-alpha was reduced by the intravenous administration of anti-asialo GM1 antibody and carrageenan.	G(M1) Ganglioside	137-140	interleukin 1 beta	Homo sapiens	33-42
1704123-7	1990	However, the functional cholera toxin receptor ganglioside Gm1 is resistant to neuraminidase treatment and periodate oxidation.	G(M1) Ganglioside	59-62	neuraminidase 1	Homo sapiens	79-92
2237979-5	1990	Chlorpromazine and the gangliosides GM1 and AGF2 promote recovery from hypoxic depression of synaptic transmission in CA1.	G(M1) Ganglioside	36-39	carbonic anhydrase 1	Rattus norvegicus	118-121
2171494-3	1990	The GM1 ganglioside species carrying the unsaturated C18 long chain base moiety proved to have the fastest rate of association, whereas the saturated species carrying 20 carbon atoms had the slowest rate.	G(M1) Ganglioside	4-19	Bardet-Biedl syndrome 9	Homo sapiens	53-56
2171494-6	1990	Moreover, the amount of cyclic AMP accumulated after a given time of incubation with cholera toxin was significantly higher when the C18:1-GM1 species was present than with native GM1.	G(M1) Ganglioside	139-142	Bardet-Biedl syndrome 9	Homo sapiens	133-136
2121675-9	1990	It was suggested that asialo GM1-positive cells and macrophage were two of the most important effectors of the antiproliferative effect of IL-1 beta and TNF-alpha.	G(M1) Ganglioside	29-32	interleukin 1 beta	Homo sapiens	139-148
2121675-9	1990	It was suggested that asialo GM1-positive cells and macrophage were two of the most important effectors of the antiproliferative effect of IL-1 beta and TNF-alpha.	G(M1) Ganglioside	29-32	tumor necrosis factor	Homo sapiens	153-162
2132741-0	1990	IgM deposits at nodes of Ranvier in a patient with amyotrophic lateral sclerosis, anti-GM1 antibodies, and multifocal motor conduction block.	G(M1) Ganglioside	87-90	immunoglobulin heavy chain 6	Rattus norvegicus	0-3
2280488-2	1990	The binding of 125I-labeled CT to neuraminidase-treated human type B erythrocytes was most effectively inhibited by ganglioside GM1 among different inhibitors used.	G(M1) Ganglioside	128-131	neuraminidase 1	Homo sapiens	34-47
2280488-4	1990	On the other hand, hemagglutination of neuraminidase-treated human type B erythrocytes by CT was inhibited by lactose, galactose, hog A + H, bovine salivary mucin, porcine thyroglobulin, and fetuin, whereas that was not effectively inhibited by ganglioside GM1 at the highest concentration.	G(M1) Ganglioside	245-260	neuraminidase 1	Homo sapiens	39-52
2252906-1	1990	The techniques of ultrafast freezing and freeze-etch electron microscopy have been successfully employed to visualize IgG molecules and Fab fragments specifically bound to the neutral glycosphingolipids Forssman and asialo-GM1 incorporated into phosphatidylcholine liposomes.	G(M1) Ganglioside	223-226	FA complementation group B	Homo sapiens	136-139
2132741-1	1990	We studied a patient with amyotrophic lateral sclerosis, multifocal motor conduction block, and IgM anti-GM1 antibodies.	G(M1) Ganglioside	105-108	immunoglobulin heavy chain 6	Rattus norvegicus	96-99
2132741-4	1990	When injected into rat sciatic nerve, the serum IgM bound to the nodes of Ranvier, and the binding activity was removed by preincubation with GM1.	G(M1) Ganglioside	142-145	immunoglobulin heavy chain 6	Rattus norvegicus	48-51
2176187-1	1990	Ganglioside (GM1) treatment of CD4+ human CEM lymphoma cells stimulated transient phosphoinositide (PI) breakdown, production of inositol phosphates (IP), protein phosphorylation and rapid decrease of CD4 surface expression.	G(M1) Ganglioside	13-16	CD4 molecule	Homo sapiens	31-34
2176187-1	1990	Ganglioside (GM1) treatment of CD4+ human CEM lymphoma cells stimulated transient phosphoinositide (PI) breakdown, production of inositol phosphates (IP), protein phosphorylation and rapid decrease of CD4 surface expression.	G(M1) Ganglioside	13-16	CD4 molecule	Homo sapiens	201-204
2231782-2	1990	In this respect, they differ from adult avian retina and other regions of the adult avian and mammalian brain, where GD3 is a minor ganglioside and gangliosides of the gangliotetraosylceramide series (GM1, GD1a, GD1b, GT1b) are the predominant ones.	G(M1) Ganglioside	201-204	GRDX	Homo sapiens	117-120
2391380-8	1990	A synergic effect between bFGF and the gangliosides (GM1, GD1b, GT1b) was observed for the improvement of survival or growth and for the acceleration of endothelial cell migration.	G(M1) Ganglioside	53-56	fibroblast growth factor 2	Bos taurus	26-30
2265511-12	1990	Immunoabsorption study demonstrated that antibodies with anti-GM1 activity were absorbed with liposomes containing purified GD1b, indicating that autoantibodies bind to the galactosyl (beta 1-3) N-acetylgalactosaminyl moiety which is shared by GM1, GD1b, and asialo-GM1.	G(M1) Ganglioside	62-65	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	185-193
2265511-12	1990	Immunoabsorption study demonstrated that antibodies with anti-GM1 activity were absorbed with liposomes containing purified GD1b, indicating that autoantibodies bind to the galactosyl (beta 1-3) N-acetylgalactosaminyl moiety which is shared by GM1, GD1b, and asialo-GM1.	G(M1) Ganglioside	244-247	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	185-193
2176187-2	1990	A comparison between the actions of GM1 and other agents that affect these signal transduction pathways demonstrated a distinct mechanism for GM1-induced decrease of CD4.	G(M1) Ganglioside	36-39	CD4 molecule	Homo sapiens	166-169
2176187-2	1990	A comparison between the actions of GM1 and other agents that affect these signal transduction pathways demonstrated a distinct mechanism for GM1-induced decrease of CD4.	G(M1) Ganglioside	142-145	CD4 molecule	Homo sapiens	166-169
2176187-6	1990	These results demonstrate that GM1 stimulates PI turnover and induces a rapid decrease of CD4 surface expression by processes that do not activate adenylate cyclase or tyrosine kinase.	G(M1) Ganglioside	31-34	CD4 molecule	Homo sapiens	90-93
2176187-7	1990	They further demonstrate that the mechanism for GM1-induced decrease of CD4 is distinct from the CD4 internalization processes mediated by PKC activity.	G(M1) Ganglioside	48-51	CD4 molecule	Homo sapiens	72-75
1693693-10	1990	Subsequent binding studies revealed that a 9.5-kDa polypeptide, which may correspond to the NH2-terminal domain (residues 1-83) of MBP, had higher affinity for the binding of lucifer yellow CH-labeled GM1 than did the other two polypeptides, of apparent molecular mass (Mr) 5,500 and 4,500, respectively.	G(M1) Ganglioside	201-204	myelin basic protein	Oryctolagus cuniculus	131-134
2229016-5	1990	In this paper, we report a modification of this HPLC/FAB/MS method, which was used for the separation and characterization of neutral glycosphingolipids (GlcCer, LacCer, Gb3Cer, Gb4Cer, and IV3 alpha GalNAc-Gb4Cer) and monosialogangliosides [GM3(NeuAc or NeuGc), GM2 (NeuAc or NeuGc), and GM1 (NeuAc or NeuGc)].	G(M1) Ganglioside	289-292	FA complementation group B	Homo sapiens	53-56
1697781-3	1990	The binding of 125I-labeled CT to neuraminidase-treated human type B erythrocytes was effectively inhibited by ganglioside GM1, but not by porcine gastric mucin with both A and H determinants (hog A + H), blood group specific lectins, and other substances at the highest concentrations used.	G(M1) Ganglioside	123-126	neuraminidase 1	Homo sapiens	34-47
2354453-5	1990	However, IL-3 in the culture fluids was detected when BCG-ILNC were treated with anti-Lyt 2.2 mAb, anti-asialo-GM1, or anti-mouse immunoglobulin antiserum followed by complement.	G(M1) Ganglioside	111-114	interleukin 3	Mus musculus	9-13
2354453-8	1990	However, serum IL-3 activity was not detected in mice treated with both SSM and Thy 1.2 or Lyt 1.2 mAb, whereas the activity was induced by SSM in mice treated with anti-Lyt 2.2 mAb or anti-asialo-GM1 antiserum.	G(M1) Ganglioside	197-200	interleukin 3	Mus musculus	15-19
2162499-5	1990	Most of the anti-GM1 antibodies appear to react with the Gal(beta 1-3)GalNAc epitope which is shared with asialo-GM1 and GD1b, but in some patients the antibodies are more specific for GM1 and associated with motor neuropathy.	G(M1) Ganglioside	17-20	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	61-69
2162499-5	1990	Most of the anti-GM1 antibodies appear to react with the Gal(beta 1-3)GalNAc epitope which is shared with asialo-GM1 and GD1b, but in some patients the antibodies are more specific for GM1 and associated with motor neuropathy.	G(M1) Ganglioside	113-116	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	61-69
2162499-5	1990	Most of the anti-GM1 antibodies appear to react with the Gal(beta 1-3)GalNAc epitope which is shared with asialo-GM1 and GD1b, but in some patients the antibodies are more specific for GM1 and associated with motor neuropathy.	G(M1) Ganglioside	113-116	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	61-69
1693693-11	1990	Among the various proteins in purified guinea pig brain myelin, synaptosomes, and synaptosomal membranes, MBP was found to have the highest affinity in binding lucifer yellow CH-GM1.	G(M1) Ganglioside	178-181	myelin basic protein	Cavia porcellus	106-109
1689771-2	1990	The Gal(beta 1-3)GalNAc epitope is shared by the gangliosides GM1 and GD1b and by several glycoproteins in the nervous system, and binding was abolished by preabsorbing the patient"s serum with GM1.	G(M1) Ganglioside	62-65	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	8-16
2320574-3	1990	Saposin B, previously known as SAP-1 and sulfatide activator, stimulates the hydrolysis of a wide variety of substrates including cerebroside sulfate, GM1 ganglioside, and globotriaosylceramide by arylsulfatase A, acid beta-galactosidase, and alpha-galactosidase, respectively.	G(M1) Ganglioside	151-166	prosaposin	Homo sapiens	31-36
1689771-2	1990	The Gal(beta 1-3)GalNAc epitope is shared by the gangliosides GM1 and GD1b and by several glycoproteins in the nervous system, and binding was abolished by preabsorbing the patient"s serum with GM1.	G(M1) Ganglioside	194-197	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	8-16
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	190-193	alpha kinase 1	Homo sapiens	73-76
2330073-5	1990	The effect of GM1, administered into the lateral ventricle and supracortically, on the release of ACh in vivo was studied, using a microdialysis system combined with sensitive high performance liquid chromatography (HPLC).	G(M1) Ganglioside	14-17	acyl-CoA thioesterase 12	Rattus norvegicus	98-101
2330073-9	1990	In contrast, KCl-stimulated release of ACh in striata from GM1-treated lesioned groups was significantly less (5-10 fold), compared to the unlesioned controls (C: 16 fold) and lesioned vehicle-treated rats (V i.c.v.	G(M1) Ganglioside	59-62	acyl-CoA thioesterase 12	Rattus norvegicus	39-42
2353349-1	1990	Intraperitoneal treatment of rat peritoneal macrophages with OK-432 results in more than 9-fold increase in the activity of ganglioside sialidase, which seems to coincide with the appearance of a cell surface antigen, asialo-GM1.	G(M1) Ganglioside	225-228	neuraminidase 3	Rattus norvegicus	124-145
2353349-2	1990	The results of subsequent studies suggest that the ganglioside sialidase is located in the plasma membrane, where the enzyme may be responsible for the formation of asialo-GM1 from GM1.	G(M1) Ganglioside	172-175	neuraminidase 3	Rattus norvegicus	51-72
2130662-7	1990	A potentiation by GM1 of NGF effects on the cholinergic neurons of the NBM occurred since no differences were detected between sham-operated rats and rats trated with NGF plus either the active (30 mg/kg) or inactive (10 mg/kg) dose of GM1.	G(M1) Ganglioside	18-21	nerve growth factor	Rattus norvegicus	25-28
2130667-0	1990	Early changes in ornithine decarboxylase activity in a partially denervated hippocampus of rats untreated and treated with GM1 ganglioside.	G(M1) Ganglioside	123-138	ornithine decarboxylase 1	Rattus norvegicus	17-40
2130667-6	1990	This study confirms the involvement of ODC in GM1 ganglioside neurotrophic effects produced in an injured brain.	G(M1) Ganglioside	46-61	ornithine decarboxylase 1	Rattus norvegicus	39-42
2182380-2	1990	The binding of 125I-labeled LTh-B to neuraminidase-treated human type B erythrocytes was most effectively inhibited by ganglioside GM1.	G(M1) Ganglioside	131-134	neuraminidase 1	Homo sapiens	37-50
2182380-6	1990	These results suggest that the predominant binding substance for LTh-B on neuraminidase-treated human type B erythrocytes is ganglioside GM1, but indicate that the interaction of LTh-B with ganglioside GM1 is different in hemagglutination.	G(M1) Ganglioside	137-140	neuraminidase 1	Homo sapiens	74-87
2182380-6	1990	These results suggest that the predominant binding substance for LTh-B on neuraminidase-treated human type B erythrocytes is ganglioside GM1, but indicate that the interaction of LTh-B with ganglioside GM1 is different in hemagglutination.	G(M1) Ganglioside	125-140	neuraminidase 1	Homo sapiens	74-87
2092040-0	1990	Enhancement of lymphocyte proliferation and IL-2 receptor expression by a processed form (GM-1/P) of monosialoganglioside GM-1.	G(M1) Ganglioside	90-94	interleukin 2 receptor, alpha chain	Mus musculus	44-57
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	190-193	alpha kinase 1	Homo sapiens	73-76
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	190-193	alpha kinase 1	Homo sapiens	73-76
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	360-363	alpha kinase 1	Homo sapiens	73-76
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	360-363	interleukin 2	Homo sapiens	136-140
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	360-363	alpha kinase 1	Homo sapiens	73-76
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	360-363	alpha kinase 1	Homo sapiens	73-76
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	360-363	alpha kinase 1	Homo sapiens	73-76
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	360-363	alpha kinase 1	Homo sapiens	73-76
2150416-3	1990	At 25 uM the capacity for inhibition of plasmin binding was GT1b greater than GQ1b greater than or equal to GD1a greater than GM1 less than or equal to GgOse 4Cer.	G(M1) Ganglioside	126-129	plasminogen	Homo sapiens	40-47
20504586-6	1990	In the same animal model peripheral, but not central, administration of GM1 reduced the hypoglycemia-induced increase of cerebral blood flow and increased the survival time observed after the insulin injection.	G(M1) Ganglioside	72-75	insulin	Homo sapiens	192-199
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	190-193	interleukin 2	Homo sapiens	136-140
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	190-193	alpha kinase 1	Homo sapiens	73-76
2272726-3	1990	Surface marker analysis of endogenous LAK cells revealed that endogenous LAK cells induced by a combined administration of lentinan and IL-2 were all NK-type LAK cells, which express asialo-GM1 and lack T3, Thy-1 and Lyt2, whereas LAK cells generated in vitro were composed of both NK-type LAK and T-type LAK cells, which express T3 and Thy-1, and lack asialo-GM1.	G(M1) Ganglioside	190-193	alpha kinase 1	Homo sapiens	73-76
15546874-3	2005	In this study, we found that galectin-4 binds to glycosphingolipids carrying 3-O-sulfated Gal residues, such as SB1a, SM3, SM4s, SB2, SM2a, and GM1, but not to glycosphingolipids with 3-O-sialylated Gal, such as sLc4Cer, snLc4Cer, GM3, GM2, and GM4, using both an enzyme-linked immunosorbent assay and a surface plasmon resonance assay.	G(M1) Ganglioside	144-147	galectin 4	Homo sapiens	29-39
15546874-4	2005	A confocal immunocytochemical assay showed that galectin-4 was colocalized with SB1a, GM1, and carcinoembryonic antigen (CEA) in the patches on the cell surface of human colon adenocarcinoma CCK-81 and LS174T cells.	G(M1) Ganglioside	86-89	galectin 4	Homo sapiens	48-58
34530055-7	2021	Moreover, hypoxia/ischemia increases the deposition of sialylated gangliosides, e.g., GM1, GM2, GM3, and GD1, which are ligands for inhibitory CD33/Siglec-3 receptors.	G(M1) Ganglioside	86-89	CD33 molecule	Homo sapiens	143-147
34877779-8	2022	These results indicate that SGCs of DRG show phenotypical changes during the course of GM1 , characterized by GFAP upregulation, proliferation and expression of a neural progenitor marker at a late time point.	G(M1) Ganglioside	87-90	glial fibrillary acidic protein	Mus musculus	110-114
34884663-0	2021	GM1 Is Cytoprotective in GPR37-Expressing Cells and Downregulates Signaling.	G(M1) Ganglioside	0-3	G protein-coupled receptor 37	Mus musculus	25-30
34884663-5	2021	Endogenous GM1 was downregulated when stably overexpressing GPR37 in N2a cells (N2aGPR37-eGFP).	G(M1) Ganglioside	11-14	G protein-coupled receptor 37	Mus musculus	60-65
34884663-8	2021	However, GM1 treatment inhibited cAMP-dependent signaling from GPR37, here reported as potentially consecutively active, possibly contributing to the protective effects.	G(M1) Ganglioside	9-12	G protein-coupled receptor 37	Mus musculus	63-68
34884663-9	2021	We propose an interplay between GPR37 and GM1 as one of the many cytoprotective effects reported for GM1.	G(M1) Ganglioside	101-104	G protein-coupled receptor 37	Mus musculus	32-37
34816592-0	2021	Pharmacological Chaperones for beta-Galactosidase Related to GM1 -Gangliosidosis and Morquio B: Recent Advances.	G(M1) Ganglioside	61-64	galactosidase beta 1	Homo sapiens	31-49
34816592-1	2021	A short survey on selected beta-galactosidase inhibitors as potential pharmacological chaperones for GM1 -gangliosidosis and Morquio B associated mutants of human lysosomal beta-galactosidase is provided highlighting recent developments in this particular area of lysosomal storage disorders and orphan diseases.	G(M1) Ganglioside	101-104	galactosidase beta 1	Homo sapiens	27-45
35635605-0	2022	The Neuroprotective Effect of GM-1 Ganglioside on the Amyloid-Beta-Induced Oxidative Stress in PC-12 Cells Mediated by Nrf-2/ARE Signaling Pathway.	G(M1) Ganglioside	30-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	119-124
34544868-5	2021	As the neurotoxic activity of amyloid oligomers increases with oligomer order, these results suggest that GM1 is neuroprotective against Abeta-mediated toxicity.	G(M1) Ganglioside	106-109	amyloid beta precursor protein	Homo sapiens	137-142
34135326-5	2021	The structure of the ceramide acyl chain still affects these domains, as co-clustering with the glycosylphosphatidylinositol (GPI)-anchored protein CD59 occurs only when GM1 contains the fully saturated C16:0 acyl chain, and not C16:1.	G(M1) Ganglioside	170-173	CD59 molecule (CD59 blood group)	Homo sapiens	148-152
35635605-10	2022	We reported herein that GM-1 could activate Nrf-2 in the PC-12 cells co-treated with Abeta25-35, following with the activated expression of antioxidant response elements (ARE)-mediated antioxidant and detoxifying genes.	G(M1) Ganglioside	24-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	44-49
35635605-11	2022	Consistently, knock-down of Nrf-2 via siRNA abolished the beneficial decrease of Abeta-induced oxidative stress by GM-1 treatment, indicating that GM-1-improved oxidative stress was regulated by the Nrf-2 signaling pathway.	G(M1) Ganglioside	115-119	NFE2 like bZIP transcription factor 2	Rattus norvegicus	28-33
35635605-11	2022	Consistently, knock-down of Nrf-2 via siRNA abolished the beneficial decrease of Abeta-induced oxidative stress by GM-1 treatment, indicating that GM-1-improved oxidative stress was regulated by the Nrf-2 signaling pathway.	G(M1) Ganglioside	115-119	NFE2 like bZIP transcription factor 2	Rattus norvegicus	199-204
35635605-11	2022	Consistently, knock-down of Nrf-2 via siRNA abolished the beneficial decrease of Abeta-induced oxidative stress by GM-1 treatment, indicating that GM-1-improved oxidative stress was regulated by the Nrf-2 signaling pathway.	G(M1) Ganglioside	147-151	NFE2 like bZIP transcription factor 2	Rattus norvegicus	28-33
35635605-11	2022	Consistently, knock-down of Nrf-2 via siRNA abolished the beneficial decrease of Abeta-induced oxidative stress by GM-1 treatment, indicating that GM-1-improved oxidative stress was regulated by the Nrf-2 signaling pathway.	G(M1) Ganglioside	147-151	NFE2 like bZIP transcription factor 2	Rattus norvegicus	199-204
35635605-12	2022	Collectively, GM-1 could alleviate Abeta25-35-induced oxidative damage mediated through the Nrf-2/ARE signaling pathway, which might be a potential agent for AD treatment.	G(M1) Ganglioside	14-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	92-97
35558506-3	2022	In this study, we found that overexpression of B3GALT4, the glycosyltransferase responsible for ganglioside GM1 synthesis, can induce the epithelial-mesenchymal transition (EMT) process in MCF-10A cells.	G(M1) Ganglioside	108-111	beta-1,3-galactosyltransferase 4	Homo sapiens	47-54
35484039-5	2022	Antibodies from three of the five responders to the vaccine prevented CTB from binding its GM1 ganglioside receptor.	G(M1) Ganglioside	91-94	phosphate cytidylyltransferase 1B, choline	Homo sapiens	70-73
35615711-1	2022	GM1-gangliosidosis is a progressive neurodegenerative glycosphingolipidosis resulting from a GLB1 gene mutation causing a deficiency of the lysosomal enzyme beta-galactosidase, which leads to the abnormal accumulation of GM1 ganglioside in the central nervous system.	G(M1) Ganglioside	221-236	galactosidase, beta 1	Mus musculus	93-97
35580354-10	2022	Moreover, the Abeta-membrane interaction was found to be governed by the repulsive electrostatic interaction between Abeta and the ganglioside GM1 lipid.	G(M1) Ganglioside	143-146	amyloid beta precursor protein	Homo sapiens	14-19
35580354-10	2022	Moreover, the Abeta-membrane interaction was found to be governed by the repulsive electrostatic interaction between Abeta and the ganglioside GM1 lipid.	G(M1) Ganglioside	143-146	amyloid beta precursor protein	Homo sapiens	117-122
35447351-0	2022	GM1 ganglioside modifies microglial and neuroinflammatory responses to alpha-synuclein in the rat AAV-A53T alpha-synuclein model of Parkinson"s disease.	G(M1) Ganglioside	0-15	synuclein alpha	Rattus norvegicus	71-86
35447351-0	2022	GM1 ganglioside modifies microglial and neuroinflammatory responses to alpha-synuclein in the rat AAV-A53T alpha-synuclein model of Parkinson"s disease.	G(M1) Ganglioside	0-15	synuclein alpha	Rattus norvegicus	107-122
35558506-5	2022	Overexpression of B3GALT4 resulted in elevated vesicular GM1 levels and increased sEV secretion in breast cancer cells.	G(M1) Ganglioside	57-60	beta-1,3-galactosyltransferase 4	Homo sapiens	18-25
2606510-4	1989	Fluorescence analysis revealed that the majority of infiltrated cells in the peritoneal cavity of IL-2-administered mice were Thy-1+, asialo GM1+, L3T4-, Ly2-.	G(M1) Ganglioside	141-144	interleukin 2	Mus musculus	98-102
35193085-11	2022	CONCLUSIONS: Erythropoietin and GM1 have therapeutic effects on axonal regeneration in mice subjected to experimental spinal cord injury, and administration of GM1 alone had the highest scores on the BMS and MFS scales.	G(M1) Ganglioside	160-163	erythropoietin	Mus musculus	13-27
35242574-11	2022	These results indicate that lysosphingolipids and NF-L/GFAP have potential to monitor pharmacodynamics and pathogenic processes respectively in GM2 and GM1 gangliosidoses patients.	G(M1) Ganglioside	152-155	neurofilament light chain	Homo sapiens	50-54
35242574-11	2022	These results indicate that lysosphingolipids and NF-L/GFAP have potential to monitor pharmacodynamics and pathogenic processes respectively in GM2 and GM1 gangliosidoses patients.	G(M1) Ganglioside	152-155	glial fibrillary acidic protein	Homo sapiens	55-59
2612575-1	1989	The administration of GM1 ganglioside, 30 mg/kg per day i.p., begun 3 days prior to an intrastriatal injection of the excitotoxic tryptophan metabolite quinolinic acid (QUIN) and continued for 8-16 days thereafter, significantly decreased QUIN-induced striatal damage, as evaluated by measuring the activity of the marker enzymes, choline acetyltransferase and L-glutamic acid decarboxylase.	G(M1) Ganglioside	22-37	choline O-acetyltransferase	Rattus norvegicus	331-356
2600605-2	1989	Meth 8 tumor cells were easily lysed in vitro by rIL-2-activated killer (AK) cells, which mainly consisted of Thy1.2+, Lyt2.2+, L3T4- T cells, and asialo GM1+ natural killer (NK) cells; on the other hand, X5563 tumor cells were only slightly lysed in vitro by AK cells under the same conditions.	G(M1) Ganglioside	154-157	interleukin 2	Rattus norvegicus	49-54
2600605-7	1989	These therapeutic effects of rIL-2 on X5563 were not seen in T-depleted mice with anti-mouse thymocyte serum but were found in NK-depleted mice upon treatment with anti-asialo-GM1 serum.	G(M1) Ganglioside	176-179	interleukin 2	Rattus norvegicus	29-34
35203252-5	2022	PolySia shows an early strong interaction with amyloid fibrils, favoring their binding to GM1 ganglioside containing alpha2,3 galactose-linked Sia and a loss of cell viability.	G(M1) Ganglioside	90-105	immunoglobulin kappa variable 2-24	Homo sapiens	117-125
35203570-4	2022	The involvement of GM1 in modulating neuronal processes has been studied in detail by in vitro experiments, and the results indicated its direct role in modulating the activity of neurotrophin-dependent receptor signaling, the flux of calcium through the plasma membrane, and stabilizing the correct conformation of proteins, such as alpha-synuclein.	G(M1) Ganglioside	19-22	synuclein alpha	Homo sapiens	334-349
2573425-4	1989	The cells mediating ADCC are closely related to LAK cells since they expressed Thy1.2 antigens and are derived from asialo GM1-positive, Lyt2/L3T4-negative, radiosensitive cells.	G(M1) Ganglioside	123-126	alpha-kinase 1	Mus musculus	48-51
2584393-4	1989	The antibodies in patient 1 reacted with GM1, GD1b, and asialo-GM1 suggesting that the terminal Gal(beta 1-3)GalNAc moiety that is common to these three glycolipids is an important part of the epitope(s).	G(M1) Ganglioside	41-44	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	100-108
2584393-4	1989	The antibodies in patient 1 reacted with GM1, GD1b, and asialo-GM1 suggesting that the terminal Gal(beta 1-3)GalNAc moiety that is common to these three glycolipids is an important part of the epitope(s).	G(M1) Ganglioside	63-66	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	100-108
2676193-7	1989	In addition, several other internal feedback controls on TCR/CD3 function, by CD4-induced tyrosine-specific phosphorylation of the CD3 zeta subunit, or on the Ca2+ signal, by extracellular Cl- or by GM1 gangliosides, are also postulated.	G(M1) Ganglioside	199-215	CD4 molecule	Homo sapiens	78-81
2481664-6	1989	Cells responding to both LHF and rIL 2 to generate LAK activity were Thy-1.2-, Lyt-1.1-, Lyt-2.1- and asialo GM1+.	G(M1) Ganglioside	109-113	interleukin 2	Rattus norvegicus	33-38
2481664-6	1989	Cells responding to both LHF and rIL 2 to generate LAK activity were Thy-1.2-, Lyt-1.1-, Lyt-2.1- and asialo GM1+.	G(M1) Ganglioside	109-113	I-kappaB kinase beta	Drosophila melanogaster	51-54
2512653-4	1989	We conclude that the ovine disease is due to a mutation at the genetic locus homologous with that of GM1 gangliosidosis and mucopolysaccharidosis type IVB, suggesting that the primary defect in the ovine disease is a mutation of the beta-galactosidase structural gene.	G(M1) Ganglioside	101-104	galactosidase beta 1	Homo sapiens	233-251
2514171-2	1989	The augmented LAK activity of PC was mediated by nonadherent, nonphagocytic, Thy-1.2+(-)- and asialo GM1+ cells.	G(M1) Ganglioside	101-104	I-kappaB kinase beta	Drosophila melanogaster	14-17
2514171-5	1989	The phenotype of N-CWS-induced PC with an elevated IL 2 responsiveness was Thy-1.2+(-)-, Lyt-1.1-, Lyt-2.1- and asialo GM1+, suggesting that the N-CWS-stimulated LAK precursors were derived mainly from the NK cell lineage.	G(M1) Ganglioside	119-122	interleukin 2	Mus musculus	51-55
2676193-7	1989	In addition, several other internal feedback controls on TCR/CD3 function, by CD4-induced tyrosine-specific phosphorylation of the CD3 zeta subunit, or on the Ca2+ signal, by extracellular Cl- or by GM1 gangliosides, are also postulated.	G(M1) Ganglioside	199-215	CD247 molecule	Homo sapiens	131-139
2478163-0	1989	CD4 modulation and inhibition of HIV-1 infectivity induced by monosialoganglioside GM1 in vitro.	G(M1) Ganglioside	62-86	CD4 molecule	Homo sapiens	0-3
2560916-6	1989	Treatment of the spleen cell donors with rabbit anti-asialo GM1 (AAGM1) abolished early production of IFN gamma in virus-infected female spleen cell cultures and reduced the early IL-2 production by infected male and female cells.	G(M1) Ganglioside	60-63	interferon gamma	Homo sapiens	102-111
2560916-6	1989	Treatment of the spleen cell donors with rabbit anti-asialo GM1 (AAGM1) abolished early production of IFN gamma in virus-infected female spleen cell cultures and reduced the early IL-2 production by infected male and female cells.	G(M1) Ganglioside	60-63	interleukin 2	Homo sapiens	180-184
2795096-6	1989	However, antitumor activity of CRP-MLV-activated PEC was inhibited by anti-Thy 1.2 and antiasialo Gm 1 antisera in the presence of complement, whereas these reagents had no effect on MTP-MLV-activated PEC.	G(M1) Ganglioside	98-102	C-reactive protein, pentraxin-related	Mus musculus	31-34
2804628-4	1989	In agreement with our previous work, we now provide further evidence that GM1 can prevent shrinkage and the decrease of choline acetyltransferase activity in the nucleus basalis magnocellularis (NBM) of the rat following a unilateral cortical lesion.	G(M1) Ganglioside	74-77	choline O-acetyltransferase	Rattus norvegicus	120-145
2478457-5	1989	Thus, the NRmAbs seemed directed at an epitope close to the GM1-binding site of CT-B.	G(M1) Ganglioside	60-63	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	80-84
2478163-1	1989	The addition of monosialoganglioside GM1 to serum-free culture medium efficiently and specifically inhibited CD4 antigen expression on normal T lymphocytes from peripheral blood or thymus as well as on cells from H9 and Molt-3 lines; other molecules such as CD3, CD2 and CD8 were not affected.	G(M1) Ganglioside	16-40	CD4 molecule	Homo sapiens	109-112
2478163-1	1989	The addition of monosialoganglioside GM1 to serum-free culture medium efficiently and specifically inhibited CD4 antigen expression on normal T lymphocytes from peripheral blood or thymus as well as on cells from H9 and Molt-3 lines; other molecules such as CD3, CD2 and CD8 were not affected.	G(M1) Ganglioside	16-40	CD2 molecule	Homo sapiens	263-266
2478163-1	1989	The addition of monosialoganglioside GM1 to serum-free culture medium efficiently and specifically inhibited CD4 antigen expression on normal T lymphocytes from peripheral blood or thymus as well as on cells from H9 and Molt-3 lines; other molecules such as CD3, CD2 and CD8 were not affected.	G(M1) Ganglioside	16-40	CD8a molecule	Homo sapiens	271-274
2478163-2	1989	Subsequent addition of fetal calf serum or bovine and human serum albumin blocked GM1 action on CD4 expression, most likely through the formation of ganglioside-albumin complexes.	G(M1) Ganglioside	82-85	CD4 molecule	Bos taurus	96-99
2478163-3	1989	Removal of GM1 from the medium was followed by the prompt reappearance of CD4 on the cell surface.	G(M1) Ganglioside	11-14	CD4 molecule	Homo sapiens	74-77
2478163-6	1989	The GM1 effect on HIV-1 infectivity, however, was not long-lasting since removal of the compound was followed by a rapid increase in viral replication, probably due to CD4 re-expression and HIV-1 propagation from a few initially infected cells.	G(M1) Ganglioside	4-7	CD4 molecule	Homo sapiens	168-171
2779846-1	1989	Immunohistochemical localization of ganglioside GM1 using 3 monoclonal antibodies (C3 and D3 reacting exclusively with GM1 and C4h2 reacting also with other gangliosides) showed different staining patterns in rat brain regions (cerebellum, cerebral cortex and hippocampus).	G(M1) Ganglioside	48-51	complement C3	Rattus norvegicus	83-92
2547442-6	1989	These findings suggest that the predominant binding substance on neuraminidase-treated human type B erythrocytes for the LTc-B is ganglioside GM1 and that the combining site of LTc-B may be specific for the terminal disaccharide (galactose-N-acetyl-D-galactosamine)-linked portion of ganglioside GM1.	G(M1) Ganglioside	142-145	neuraminidase 1	Homo sapiens	65-78
2547442-6	1989	These findings suggest that the predominant binding substance on neuraminidase-treated human type B erythrocytes for the LTc-B is ganglioside GM1 and that the combining site of LTc-B may be specific for the terminal disaccharide (galactose-N-acetyl-D-galactosamine)-linked portion of ganglioside GM1.	G(M1) Ganglioside	296-299	neuraminidase 1	Homo sapiens	65-78
2474454-1	1989	Recent reports that myelin basic protein (MBP) can be ADP-ribosylated and contains specific sites that bind GTP and GM1 ganglioside, have suggested an analogy to the properties of cholera toxin.	G(M1) Ganglioside	116-131	myelin basic protein	Homo sapiens	20-40
2474454-1	1989	Recent reports that myelin basic protein (MBP) can be ADP-ribosylated and contains specific sites that bind GTP and GM1 ganglioside, have suggested an analogy to the properties of cholera toxin.	G(M1) Ganglioside	116-131	myelin basic protein	Homo sapiens	42-45
2779846-1	1989	Immunohistochemical localization of ganglioside GM1 using 3 monoclonal antibodies (C3 and D3 reacting exclusively with GM1 and C4h2 reacting also with other gangliosides) showed different staining patterns in rat brain regions (cerebellum, cerebral cortex and hippocampus).	G(M1) Ganglioside	119-122	complement C3	Rattus norvegicus	83-92
2516403-2	1989	Injecting a combination of rHIL-2 and rIFN-beta into mice with adenocarcinoma-755 or colon-38 tumors resulted in a marked increase in L3T4+, Lyt-2+ and asialo GM1+ cells in the peritoneal cavity.	G(M1) Ganglioside	159-162	interferon beta 1	Rattus norvegicus	38-47
2744127-4	1989	In contrast, GM1 enhanced the ODC response produced by kainic acid in the injected but not the uninjected hippocampus.	G(M1) Ganglioside	13-16	ornithine decarboxylase 1	Homo sapiens	30-33
2744127-7	1989	Ganglioside GM1 altered the ODC response without minimizing the histopathological changes induced by the cytotoxins.	G(M1) Ganglioside	12-15	ornithine decarboxylase 1	Homo sapiens	28-31
2516403-4	1989	Thus, sensitive tumors (adenocarcinoma-755 and colon-38) in combined treatment with rHIL-2 and rIFN-beta markedly increased L3T4+, Lyt-2+ and asialo GM1+ cells in the peritoneal cavity, but the insensitive tumor (Lewis lung carcinoma) did not.	G(M1) Ganglioside	149-152	interferon beta 1	Rattus norvegicus	95-104
2670153-2	1989	The binding of 125I-labeled LTp to neuraminidase-treated human type A erythrocytes was most effectively inhibited by ganglioside GM1.	G(M1) Ganglioside	129-132	neuraminidase 1	Homo sapiens	35-48
2470785-1	1989	IgM monoclonal antibodies (M-proteins) with anti-Gal(beta 1-3)GalNAc and anti-Gal(beta 1-3)GlcNAc activity that bind to gangliosides GD1b and GM1, from two patients with lower motor neuron disease were tested for binding to neural glycoproteins.	G(M1) Ganglioside	142-145	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	82-90
2649154-2	1989	The binding of 125I-labeled LTp to neuraminidase-treated human type A erythrocytes was most effectively inhibited by ganglioside GM1 among inhibitors used.	G(M1) Ganglioside	117-132	neuraminidase 1	Homo sapiens	35-48
2760636-4	1989	In contrast to anti-viral antibodies, anti-MBP and GM1 antibodies belonged to IgG1, IgG3 or IgG4 in MS.	G(M1) Ganglioside	51-54	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	84-88
2649154-5	1989	On the other hand, hemagglutination of neuraminidase-treated human type A erythrocytes by LTp was inhibited by methyl alpha-D-galactopyranoside, galactose, melibiose and some glycoproteins, but not effectively inhibited by ganglioside GM1 at the highest concentration used.	G(M1) Ganglioside	223-238	neuraminidase 1	Homo sapiens	39-52
2649154-7	1989	Although these findings show that there may be fundamental differences between interactions with ganglioside GM1 in hemagglutination compared to interactions with ganglioside GM1 in binding, the predominant binding substance for LTp on neuraminidase-treated human type A erythrocytes is suggested to be ganglioside GM1.	G(M1) Ganglioside	175-178	neuraminidase 1	Homo sapiens	236-249
2537177-0	1989	Islet cell-activating protein reverses anti-fucosyl GM1 ganglioside antibody-induced inhibition of adenosine 3",5"-monophosphate production in FRTL-5 rat thyroid cells.	G(M1) Ganglioside	52-67	magnesium transporter 1	Rattus norvegicus	0-29
2647849-2	1989	We have previously demonstrated that incubation with IL-2 can induce ADCC activity in murine cells and that this activity was mediated by asialo GM1+, FcR+ cells.	G(M1) Ganglioside	145-149	interleukin 2	Mus musculus	53-57
2647849-5	1989	The precursors of the ADCC induced by the combination of IL-1 and IL-2 were asialo GM1+ cells, similar to the precursor cells of IL-2-induced ADCC.	G(M1) Ganglioside	83-86	JIL-1 kinase	Drosophila melanogaster	57-61
2647849-5	1989	The precursors of the ADCC induced by the combination of IL-1 and IL-2 were asialo GM1+ cells, similar to the precursor cells of IL-2-induced ADCC.	G(M1) Ganglioside	83-86	interleukin 2	Mus musculus	66-70
2784081-0	1989	Effect of IL-2 in vitro on CTL generation in spleen cells of young and old mice: asialo GM1+ cells are required for the apparent restoration of the CTL response.	G(M1) Ganglioside	88-91	ctl	Drosophila melanogaster	148-151
2928318-2	1989	Following unilateral decortication of rats, GM1 (5 mg/kg per day) administered intracerebroventricularly could protect forebrain cholinergic neurons of the nucleus basalis magnocellularis from retrograde degeneration in a manner comparable to beta-NGF.	G(M1) Ganglioside	44-47	nerve growth factor	Rattus norvegicus	243-251
2783950-10	1989	A-LAK cells derived from spleen or bone marrow of C57BL/6 or nude mice treated with anti-asialo GM1 serum were found to be asialo GM1+ suggesting that A-LAK cell could be generated from the asialo GM1- precursor cells.	G(M1) Ganglioside	96-99	I-kappaB kinase beta	Drosophila melanogaster	2-5
2783950-10	1989	A-LAK cells derived from spleen or bone marrow of C57BL/6 or nude mice treated with anti-asialo GM1 serum were found to be asialo GM1+ suggesting that A-LAK cell could be generated from the asialo GM1- precursor cells.	G(M1) Ganglioside	96-99	I-kappaB kinase beta	Drosophila melanogaster	153-156
2783950-10	1989	A-LAK cells derived from spleen or bone marrow of C57BL/6 or nude mice treated with anti-asialo GM1 serum were found to be asialo GM1+ suggesting that A-LAK cell could be generated from the asialo GM1- precursor cells.	G(M1) Ganglioside	130-133	I-kappaB kinase beta	Drosophila melanogaster	2-5
2783950-10	1989	A-LAK cells derived from spleen or bone marrow of C57BL/6 or nude mice treated with anti-asialo GM1 serum were found to be asialo GM1+ suggesting that A-LAK cell could be generated from the asialo GM1- precursor cells.	G(M1) Ganglioside	130-133	I-kappaB kinase beta	Drosophila melanogaster	153-156
2783950-10	1989	A-LAK cells derived from spleen or bone marrow of C57BL/6 or nude mice treated with anti-asialo GM1 serum were found to be asialo GM1+ suggesting that A-LAK cell could be generated from the asialo GM1- precursor cells.	G(M1) Ganglioside	130-133	I-kappaB kinase beta	Drosophila melanogaster	2-5
2783950-10	1989	A-LAK cells derived from spleen or bone marrow of C57BL/6 or nude mice treated with anti-asialo GM1 serum were found to be asialo GM1+ suggesting that A-LAK cell could be generated from the asialo GM1- precursor cells.	G(M1) Ganglioside	130-133	I-kappaB kinase beta	Drosophila melanogaster	153-156
2645382-7	1989	On the other hand, postmitotic Muller cells obtained from 13-day-old embryo (R13) or 1-day-old hatched chick retina (RP1) expressed GD3, GM1, and polysialosyl-GTC but were unable to maintain the expression of these GTCs when kept in culture for several days.	G(M1) Ganglioside	137-140	RP1 axonemal microtubule associated	Gallus gallus	117-120
2928318-4	1989	Concentrations of GM1 that were ineffective when administered alone in this lesion model, when given with beta-NGF, potentiated beta-NGF effects in both of the above brain areas.	G(M1) Ganglioside	18-21	nerve growth factor	Rattus norvegicus	106-114
2928318-4	1989	Concentrations of GM1 that were ineffective when administered alone in this lesion model, when given with beta-NGF, potentiated beta-NGF effects in both of the above brain areas.	G(M1) Ganglioside	18-21	nerve growth factor	Rattus norvegicus	128-136
2928318-6	1989	A moderate (up to 35%) stimulation of choline acetyltransferase activity was observed with 10 microM GM1.	G(M1) Ganglioside	101-104	choline O-acetyltransferase	Rattus norvegicus	38-63
2928318-3	1989	Administered in combination with beta-NGF, GM1 produced a significant increase in choline acetyltransferase activity in the nucleus basalis magnocellularis and remaining cortex ipsilateral to the lesion.	G(M1) Ganglioside	43-46	nerve growth factor	Rattus norvegicus	33-41
2928318-7	1989	The application of beta-NGF in combination with 10 microM GM1 or 0.1 microM GM1, a concentration that is ineffective in these cultures, produced a much greater increase in choline acetyltransferase activity than did beta-NGF alone.	G(M1) Ganglioside	58-61	choline O-acetyltransferase	Rattus norvegicus	172-197
2928318-7	1989	The application of beta-NGF in combination with 10 microM GM1 or 0.1 microM GM1, a concentration that is ineffective in these cultures, produced a much greater increase in choline acetyltransferase activity than did beta-NGF alone.	G(M1) Ganglioside	76-79	choline O-acetyltransferase	Rattus norvegicus	172-197
2928318-7	1989	The application of beta-NGF in combination with 10 microM GM1 or 0.1 microM GM1, a concentration that is ineffective in these cultures, produced a much greater increase in choline acetyltransferase activity than did beta-NGF alone.	G(M1) Ganglioside	76-79	nerve growth factor	Rattus norvegicus	216-224
2928318-3	1989	Administered in combination with beta-NGF, GM1 produced a significant increase in choline acetyltransferase activity in the nucleus basalis magnocellularis and remaining cortex ipsilateral to the lesion.	G(M1) Ganglioside	43-46	choline O-acetyltransferase	Rattus norvegicus	82-107
2928318-9	1989	That GM1 increases and even potentiates beta-NGF effects suggests that some of the trophic actions of this compound may be mediated through endogenous trophic factors.	G(M1) Ganglioside	5-8	nerve growth factor	Rattus norvegicus	40-48
2715723-9	1989	The non-inducers of differentiation, GM1 and sulfatides, also increased the activity of ST1, but to a much lesser extent.	G(M1) Ganglioside	37-40	syndecan binding protein	Homo sapiens	88-91
2713652-11	1989	The latter finding indicates a potentiation by GM1 of NGF effects on the cholinergic neurons of the NBM.	G(M1) Ganglioside	47-50	nerve growth factor	Rattus norvegicus	54-57
2715723-7	1989	The activity of CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase (ST1), a key enzyme for membrane gangliosides synthesis, in HL-60 cells was also influenced by the exposure to TPA, GM3, DMSO, GM1, or sulfatides.	G(M1) Ganglioside	206-209	syndecan binding protein	Homo sapiens	80-83
2536394-2	1989	The serum IgM M-protein bound preferentially to ganglioside GM1 with slight cross-reactivity to both GM2 and GD1b.	G(M1) Ganglioside	60-63	myomesin 2	Homo sapiens	14-23
3206532-6	1988	Antibody and complement depletion experiments showed that both anti-YAC-1 and anti-P815 activity could be depleted with antiserum to the asialo-GM1 cell surface marker, but was unaffected by anti-Lyt-1.2 and anti-Lyt-2.2 treatment.	G(M1) Ganglioside	144-147	ADP-ribosyltransferase 1	Mus musculus	68-73
2784553-4	1989	In addition, in the presence of gangliosides (GM1, GD1a, GD1b GT1b), the numbers of regrown RGC axons (Thy 1-immunostained) increased dramatically as compared to controls.	G(M1) Ganglioside	46-49	Thy-1 cell surface antigen	Rattus norvegicus	103-108
2468413-6	1989	This finding indicates that (a) the IFN-gamma is produced by Thy-1-positive cells and (b) the production of IFN-gamma by these cells is at least partially under the control of asialo-GM1-positive cells.	G(M1) Ganglioside	183-186	interferon gamma	Mus musculus	36-45
2468413-6	1989	This finding indicates that (a) the IFN-gamma is produced by Thy-1-positive cells and (b) the production of IFN-gamma by these cells is at least partially under the control of asialo-GM1-positive cells.	G(M1) Ganglioside	183-186	interferon gamma	Mus musculus	108-117
3065089-5	1988	LFA-1 high lymphocytes possessed a high level of asialo GM1, which was the cell surface marker for NK cells.	G(M1) Ganglioside	56-59	integrin beta 2	Mus musculus	0-5
2530410-4	1989	A comparison between the results of these binding studies and ganglioside-induced decrease of CD4 expression demonstrated that every aspect of [3H]-GM1 binding concurs with ganglioside modulation of CD4 expression.	G(M1) Ganglioside	148-151	Cd4 molecule	Rattus norvegicus	94-97
2530410-4	1989	A comparison between the results of these binding studies and ganglioside-induced decrease of CD4 expression demonstrated that every aspect of [3H]-GM1 binding concurs with ganglioside modulation of CD4 expression.	G(M1) Ganglioside	148-151	Cd4 molecule	Rattus norvegicus	199-202
2771061-2	1989	Intraventricular administration of the monosialoganglioside GM1 (5 mg/kg per day), via minipumps, over a period of 14 days prevented this fall in choline acetyltransferase activity.	G(M1) Ganglioside	60-63	choline O-acetyltransferase	Rattus norvegicus	146-171
3048654-6	1988	The rIL-2 therapy effectively enhances both antitumor and antiviral NK/LAK activity and results in a noticeable increase in asialo-GM1-positive cells in the spleens of treated mice as well as a significant increase in IL-2 receptor expression as monitored by either cytometry or radioligand binding.	G(M1) Ganglioside	131-134	interleukin 2	Rattus norvegicus	4-9
3048654-6	1988	The rIL-2 therapy effectively enhances both antitumor and antiviral NK/LAK activity and results in a noticeable increase in asialo-GM1-positive cells in the spleens of treated mice as well as a significant increase in IL-2 receptor expression as monitored by either cytometry or radioligand binding.	G(M1) Ganglioside	131-134	interleukin 2	Rattus norvegicus	5-9
3263543-6	1988	Antiserum to the glycolipid asialo GM1 (ganglio-n-tetrosylceramide), given simultaneously with rIL-2, prevented overt toxicity of rIL-2 (mortality, vascular leak syndrome, and hepatic damage) and substantially reduced infiltration of pulmonary and hepatic vasculature by asialo GM1+ lymphocytes.	G(M1) Ganglioside	35-38	interleukin 2	Rattus norvegicus	130-135
3263543-8	1988	Additionally, asialo GM1 antisera prevented toxicity, but not anti-tumor efficacy, of high dose rIL-2 therapy in BDF mice bearing the colon 38 adenocarcinoma.	G(M1) Ganglioside	21-24	interleukin 2	Rattus norvegicus	96-101
3171179-4	1988	By contrast, the veto and NS activities of lymphokine-activated bone marrow cells are both abrogated by C lysis depletion of cells expressing Qa-2, Qa-5, Thy-1, asialo GM1, NK1, and Ly-11, but are unaffected by depletion of cells expressing Ly-2.	G(M1) Ganglioside	168-171	interleukin 2	Homo sapiens	43-53
2457603-2	1988	In previous studies, both M-proteins bound to gangliosides GM1 and GD1b which share Gal(beta 1-3)GalNAc as their terminal structure, and to lacto-N-tetraose-BSA which has the structure Gal(beta 1-3)GlcNAc(beta 1-3)Gal(beta 1-4)Glc-BSA.	G(M1) Ganglioside	59-62	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	88-96
3139303-6	1988	Phenotypic analysis showed that virtually all of the LAK precursor cells were asialo GM1+ and most of the effector cells expressed Thy-1, regardless of the age of the mice.	G(M1) Ganglioside	85-89	I-kappaB kinase beta	Drosophila melanogaster	53-56
2457603-2	1988	In previous studies, both M-proteins bound to gangliosides GM1 and GD1b which share Gal(beta 1-3)GalNAc as their terminal structure, and to lacto-N-tetraose-BSA which has the structure Gal(beta 1-3)GlcNAc(beta 1-3)Gal(beta 1-4)Glc-BSA.	G(M1) Ganglioside	59-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	88-94
2457654-7	1988	The data suggest that the epitope for both of these IgMs is in the GalNAc(beta 1-4)(NeuAc alpha 2-3)Gal(beta 1-4)Glc region of the gangliosides that is common to both GM2 and GM1.	G(M1) Ganglioside	175-178	tubulin beta 3 class III	Homo sapiens	74-82
2457654-7	1988	The data suggest that the epitope for both of these IgMs is in the GalNAc(beta 1-4)(NeuAc alpha 2-3)Gal(beta 1-4)Glc region of the gangliosides that is common to both GM2 and GM1.	G(M1) Ganglioside	175-178	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	104-112
3048385-0	1988	Biosynthesis and molecular cloning of sulfated glycoprotein 1 secreted by rat Sertoli cells: sequence similarity with the 70-kilodalton precursor to sulfatide/GM1 activator.	G(M1) Ganglioside	159-162	prosaposin	Rattus norvegicus	38-61
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	G(M1) Ganglioside	29-32	granulocyte macrophage antigen 3	Mus musculus	98-101
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	G(M1) Ganglioside	29-32	cytochrome b5 domain containing 2	Mus musculus	118-121
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	G(M1) Ganglioside	29-32	granulocyte macrophage antigen 3	Mus musculus	147-150
3146253-4	1988	6-HMGal analogues with shorter acyl residues, octanoyl (OMGal) and butanoyl (BMGal), were cleaved by another type of beta-galactosidase, GM1-ganglioside-beta-galactosidase.	G(M1) Ganglioside	137-152	galactosidase beta 1	Homo sapiens	117-135
3146253-4	1988	6-HMGal analogues with shorter acyl residues, octanoyl (OMGal) and butanoyl (BMGal), were cleaved by another type of beta-galactosidase, GM1-ganglioside-beta-galactosidase.	G(M1) Ganglioside	137-152	galactosidase beta 1	Homo sapiens	153-171
3259967-0	1988	Role of asialo-GM1-positive lymphoid cells in mediating the toxic effects of recombinant IL-2 in mice.	G(M1) Ganglioside	15-18	interleukin 2	Mus musculus	89-93
3259967-8	1988	Moreover, treatment of mice with anti-asialo-GM1 (anti-ASGM-1) antiserum in vivo at the same time they were receiving toxic doses of rIL-2 abolished or greatly reduced the severity of the vascular leak syndrome and hepatotoxicity and significantly prolonged the survival of the mice.	G(M1) Ganglioside	45-48	interleukin 2	Rattus norvegicus	133-138
3048385-7	1988	An internal region of SGP-1 shows 78% sequence identity with the 67 N-terminal amino acids described for human sulfatide/GM1 activator (SAP-1).	G(M1) Ganglioside	121-124	prosaposin	Rattus norvegicus	22-27
3048385-7	1988	An internal region of SGP-1 shows 78% sequence identity with the 67 N-terminal amino acids described for human sulfatide/GM1 activator (SAP-1).	G(M1) Ganglioside	121-124	prosaposin	Homo sapiens	136-141
3048385-8	1988	Sequence comparisons suggest that SGP-1 is the precursor to sulfatide/GM1 activator; however, the secretion of the protein from Sertoli cells is distinct from the proteolytic processing and lysosomal compartmentalization which have been described for human fibroblasts.	G(M1) Ganglioside	70-73	prosaposin	Rattus norvegicus	34-39
2837525-7	1988	were sensitive to administration of anti-asialo GM1 serum in vivo, were Lyt-2-, and were enriched in populations that lysed NK cell-sensitive targets in vitro, indicating that these were NK/LGL.	G(M1) Ganglioside	48-51	legless	Mus musculus	190-193
3259481-8	1988	However, in the presence of the Gm1,17;..;21 haplotype subjects positive for HLA-B8/DR3 did not respond better to mitogenic stimulation than those lacking this HLA haplotype.	G(M1) Ganglioside	32-35	TNF receptor superfamily member 25	Homo sapiens	77-87
3169039-3	1988	While some attachment of unsupplemented cells was noted on CTB substrata, GM1 supplementation permitted F11 cells to attach as well on CTB as on pFN or PF4.	G(M1) Ganglioside	74-77	phosphate cytidylyltransferase 1B, choline	Homo sapiens	135-138
3169039-3	1988	While some attachment of unsupplemented cells was noted on CTB substrata, GM1 supplementation permitted F11 cells to attach as well on CTB as on pFN or PF4.	G(M1) Ganglioside	74-77	platelet factor 4	Homo sapiens	152-155
3169039-6	1988	The formation of both neurite classes on either pFN or CTB was completely inhibited by low concentrations of an RGDS (Arg-Gly-Asp-Ser) peptide in the medium of cultures, indicating the significance of pFN"s binding to cell surface integrin or ganglioside GM1"s possible interaction with integrin for mediating the differentiative process.	G(M1) Ganglioside	255-258	ral guanine nucleotide dissociation stimulator	Homo sapiens	112-116
3253621-2	1988	The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (beta 1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (beta 1-3) GlcNAc.	G(M1) Ganglioside	135-138	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	85-93
3360793-5	1988	The oligosaccharide of GM1 and deacetyl-fatty acid free GM1 (II3-NeuGg-Ose4-sphingosine) were hydrolyzed by beta-galactosidase in the absence of this activator protein.	G(M1) Ganglioside	23-26	galactosidase beta 1	Homo sapiens	108-126
3378149-0	1988	GM1 ganglioside potentiates the effect of nerve growth factor in preventing vinblastine-induced sympathectomy in newborn rats.	G(M1) Ganglioside	0-15	nerve growth factor	Rattus norvegicus	42-61
3378149-7	1988	The systemic administration of GM1 (30 mg/kg) on P3, P4 and P5, was able to potentiate the NGF activity in preventing the VNB-induced sympathectomy.	G(M1) Ganglioside	31-34	nerve growth factor	Rattus norvegicus	91-94
3360793-5	1988	The oligosaccharide of GM1 and deacetyl-fatty acid free GM1 (II3-NeuGg-Ose4-sphingosine) were hydrolyzed by beta-galactosidase in the absence of this activator protein.	G(M1) Ganglioside	56-59	galactosidase beta 1	Homo sapiens	108-126
3378149-8	1988	This GM1 effect was more evident in the heart and may be, at least in part, attributed to increased NGF prevention of neuronal cell death due to VNB.	G(M1) Ganglioside	5-8	nerve growth factor	Rattus norvegicus	100-103
3128327-0	1988	beta-Galactosidase-induced destabilization of liposome composed of phosphatidylethanolamine and ganglioside GM1.	G(M1) Ganglioside	108-111	galactosidase beta 1	Homo sapiens	0-18
3389760-1	1988	We demonstrated that an IgM M-protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1.	G(M1) Ganglioside	123-126	myomesin 2	Homo sapiens	28-37
3389760-1	1988	We demonstrated that an IgM M-protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1.	G(M1) Ganglioside	145-148	myomesin 2	Homo sapiens	28-37
3128479-2	1988	With complement-mediated serologic depletion of murine splenocytes, the cellular sources of IFN-gamma following in vitro stimulation with L. pneumophila antigens were Thy-1.2+, Lyt-2-, L3T4-, and asialo-GM1+, which is consistent with the natural killer (NK) cell phenotype.	G(M1) Ganglioside	203-206	interferon gamma	Mus musculus	92-101
3133384-0	1988	Microassay for GM1 ganglioside beta-galactosidase activity using high-performance liquid chromatography.	G(M1) Ganglioside	15-18	galactosidase beta 1	Homo sapiens	31-49
3133384-1	1988	A simple and sensitive assay for GM1 ganglioside (GM1) beta-galactosidase activity was devised by direct measurement of released D-galactose using high-performance liquid chromatography (HPLC).	G(M1) Ganglioside	33-48	galactosidase beta 1	Homo sapiens	55-73
3133384-1	1988	A simple and sensitive assay for GM1 ganglioside (GM1) beta-galactosidase activity was devised by direct measurement of released D-galactose using high-performance liquid chromatography (HPLC).	G(M1) Ganglioside	33-36	galactosidase beta 1	Homo sapiens	55-73
3128327-4	1988	Treatment of these GM1/PE liposomes with beta-galactosidase induces a rapid leakage (3-6 min) of the entrapped fluorescent dye, calcein.	G(M1) Ganglioside	19-22	galactosidase beta 1	Homo sapiens	41-59
3370722-5	1988	Laser-light scattering measurements show that GM1(NeuGc) aggregates in aqueous media being present in solution as micelles with a molecular weight of 576,000 and a hydrodynamic radius of 62.4 A as determined at 25 degrees C. GM1(NeuGc) promotes neurite outgrowth in N-2a cells to a similar degree as GM1(NeuAc), but shows different behaviour under treatment with sialidase from Arthrobacter ureafaciens.	G(M1) Ganglioside	46-49	coenzyme Q10A	Mus musculus	225-235
2966069-1	1988	Human neuroblastoma cells (Platt and La-N1) adhere and extend neurites on a ganglioside GM1-binding substratum provided by cholera toxin B (CTB).	G(M1) Ganglioside	88-91	chitobiase	Homo sapiens	140-143
2966069-5	1988	The involvement of two pFN receptor molecules in ganglioside GM1-mediated responses on CTB have now been tested.	G(M1) Ganglioside	61-64	chitobiase	Homo sapiens	87-90
3349084-1	1988	Ganglioside GM1 inhibited either DNA synthesis in isolated nuclei or the activity of DNA polymerase alpha fractionated from S-phase HeLa cells.	G(M1) Ganglioside	0-15	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	85-105
3349084-2	1988	The concentrations of GM1 necessary for 50% inhibition were about 5 microM and 10 microM for nuclei and DNA polymerase alpha, respectively.	G(M1) Ganglioside	22-25	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	104-124
3349084-7	1988	Binding of GM1 and DNA polymerase alpha was suggested by the cocentrifugation of GM1 and the enzyme fraction after their preincubation.	G(M1) Ganglioside	81-84	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	19-39
3125989-3	1988	Consistent with an in vitro system, we demonstrate that Thy 1.2+, Ly2+, asialo GM1+ LAK cells were successfully induced by in vivo immunization with syngeneic IL-2-producing EL4 lymphoma cells.	G(M1) Ganglioside	79-82	interleukin 2	Mus musculus	159-163
3126266-5	1988	When the cells were cultured in the presence of nerve growth factor (NGF), GM1, GM2, and a ganglioside mixture, marked morphological differentiation was observed in the presence of NGF, and the specificity of the binding was also affected.	G(M1) Ganglioside	75-78	nerve growth factor	Rattus norvegicus	181-184
3257412-9	1988	The proliferative response of rat spleen or blood lymphocytes to rIL-2 appeared to be primarily associated with LGL/NK cells since depletion of NK cells by anti-asialo-GM1 or anti-laminin antibody plus complement or by L-leucine methyl ester significantly (P less than 0.001) reduced the incorporation of [3H]thymidine into DNA.	G(M1) Ganglioside	168-171	interleukin 2	Rattus norvegicus	65-70
3346542-7	1988	Binding assays with radiolabeled H showed increased binding of H to liposome-bound C3b in the presence of GM1.	G(M1) Ganglioside	106-109	complement C3	Homo sapiens	83-86
3124978-2	1988	Stable liposomes with entrapped glucose-6-phosphate dehydrogenase (G6PDH) were prepared with unsaturated PE stabilized with 5 mol percent of ganglioside GM1.	G(M1) Ganglioside	141-156	glucose-6-phosphate dehydrogenase	Homo sapiens	32-65
3124978-2	1988	Stable liposomes with entrapped glucose-6-phosphate dehydrogenase (G6PDH) were prepared with unsaturated PE stabilized with 5 mol percent of ganglioside GM1.	G(M1) Ganglioside	141-156	glucose-6-phosphate dehydrogenase	Homo sapiens	67-72
3124978-3	1988	Addition of beta-galactosidase caused rapid (3-5 min) lysis of liposomes, revealing the latent G6PDH activity, owing to the enzymatic degalactosylation of GM1.	G(M1) Ganglioside	155-158	glucose-6-phosphate dehydrogenase	Homo sapiens	95-100
2448375-2	1988	Injection of anti-asialo-GM1 (ASGM1) into transplanted mice strongly suppresses splenic cytotoxic activity and causes a significant reduction of spleen cells expressing ASGM1, Thy-1, and Lyt-2.	G(M1) Ganglioside	25-28	thymus cell antigen 1, theta	Mus musculus	176-181
2448375-2	1988	Injection of anti-asialo-GM1 (ASGM1) into transplanted mice strongly suppresses splenic cytotoxic activity and causes a significant reduction of spleen cells expressing ASGM1, Thy-1, and Lyt-2.	G(M1) Ganglioside	25-28	CD8 antigen, alpha chain	Mus musculus	187-192
3665224-6	1987	Thus, in vivo treatment of nude mice with anti-asialo GM1, a procedure known to remove NK cells, partially reversed the inhibitory effects of theophylline on tumor formation and generation of metastasis by Cd-16 cells.	G(M1) Ganglioside	54-57	Fc gamma receptor IIIa	Homo sapiens	206-211
2458181-4	1988	The NK cell nature of the effector cells activated by TNF was substantiated by the finding that previous injection with anti-asialo GM 1 antibody prevented activation.	G(M1) Ganglioside	132-136	tumor necrosis factor	Homo sapiens	54-57
3334724-2	1988	The genetic analysis using C57BL/10 (GM1-negative) and SWR (GM1-positive) mice revealed that a single autosomal gene (Ggm-1) was involved in the expression of liver GM1(NeuGc) and that C57BL/10 mice lacking GM1(NeuGc) expression carried a defective gene on Ggm-1.	G(M1) Ganglioside	37-40	ganglioside expression 1	Mus musculus	118-123
3334724-2	1988	The genetic analysis using C57BL/10 (GM1-negative) and SWR (GM1-positive) mice revealed that a single autosomal gene (Ggm-1) was involved in the expression of liver GM1(NeuGc) and that C57BL/10 mice lacking GM1(NeuGc) expression carried a defective gene on Ggm-1.	G(M1) Ganglioside	60-63	ganglioside expression 1	Mus musculus	118-123
3257251-7	1988	2-h rIL-2-activated plastic adherent lymphocytes were 90-98% LGL, expressed surface markers characteristic of rat NK cells (OX8 [CD8]+, asialo GM1, laminin+, OX19 [CD5]-, R1-3B3 [CD5]-, W3/25 [CD4]-, OX39 [CD25]-, Ia-, and Ig-), and expressed very high levels of cytotoxicity against YAC-1 target cells.	G(M1) Ganglioside	143-146	interleukin 2	Rattus norvegicus	4-9
3117976-3	1987	After supplementation of the culture medium with ganglioside GM1, the PC12 cells were found to express type B MAO activity after 4 days of culture, and the amount of type B activity increased with the number of days of culture.	G(M1) Ganglioside	61-64	monoamine oxidase A	Rattus norvegicus	110-113
3117976-5	1987	By kinetic analyses of type A and B MAO in PC12h cells after 3 weeks of culture, the increase of type B MAO activity was found to be due to the increase in amount of type B MAO; the Km values were almost the same and only the Vmax values were increased in the cells supplemented with GM1.	G(M1) Ganglioside	284-287	monoamine oxidase A	Rattus norvegicus	104-107
3117976-5	1987	By kinetic analyses of type A and B MAO in PC12h cells after 3 weeks of culture, the increase of type B MAO activity was found to be due to the increase in amount of type B MAO; the Km values were almost the same and only the Vmax values were increased in the cells supplemented with GM1.	G(M1) Ganglioside	284-287	monoamine oxidase A	Rattus norvegicus	104-107
3117976-6	1987	Among gangliosides tested GM1 was the most effective in causing expression of type B MAO activity, whereas nerve growth factor was not effective.	G(M1) Ganglioside	26-29	monoamine oxidase A	Rattus norvegicus	85-88
3117976-7	1987	These results suggest that GM1 and other gangliosides may be involved in the expression of type B MAO in nerve cells and in the regulation of levels of the biogenic amines in the brain.	G(M1) Ganglioside	27-30	monoamine oxidase A	Rattus norvegicus	98-101
3346623-5	1988	The immune response thus generated to LTB and K99 pili could be completely abolished by cofeeding a number of sugars that have close structural homology to the terminal sugars of the GM1 and GM2 gangliosides to which these molecules are known to bind.	G(M1) Ganglioside	183-186	lymphotoxin beta	Homo sapiens	38-41
3213581-2	1988	The addition of a mixture of bovine brain gangliosides (BBG) or the monosialoganglioside GM1 to this medium potentiated the nerve growth factor (NGF)-independent CM-mediated neuritogenesis.	G(M1) Ganglioside	89-92	nerve growth factor	Bos taurus	124-143
3213581-2	1988	The addition of a mixture of bovine brain gangliosides (BBG) or the monosialoganglioside GM1 to this medium potentiated the nerve growth factor (NGF)-independent CM-mediated neuritogenesis.	G(M1) Ganglioside	89-92	nerve growth factor	Bos taurus	145-148
2887687-6	1987	The presence of a second inhibitory mechanism in CP-treated mice was found following asialo GM1 treatment or Percoll density gradient separation of erythroblast-depleted CP splenocytes; this inhibitory population was identified as Thy 1.2+ lymphocytes.	G(M1) Ganglioside	92-95	thymus cell antigen 1, theta	Mus musculus	231-238
2442258-10	1987	Bone marrow cells depleted of Thy-1+, Lyt-1+, Lyt-2+, NK-1.1+, Asialo GM1+, or Qa-5+ cells were as susceptible to IL-2 induced suppression as untreated or complement-treated bone marrow cells.	G(M1) Ganglioside	70-73	interleukin 2	Mus musculus	114-118
3495490-5	1987	This finding suggests that in addition to the conventional, asialo GM1- LAK cells, asialo GM1+ activated NK cells participated in the cytotoxicity displayed by the IL-2-activated nu/nu killer spleen cells.	G(M1) Ganglioside	67-70	I-kappaB kinase beta	Drosophila melanogaster	72-75
2436487-7	1987	Exposure of the tissue"s mucosal surface to GM1 ganglioside, (the natural receptor for the CT b subunit) yielded maximal stimulation of water flow and near-maximal urea transport, presumably by increasing CT"s binding to the cell membrane.	G(M1) Ganglioside	44-59	chitobiase	Homo sapiens	91-95
3104072-4	1987	Supplementation of the cells with exogenous GM1, but not GD1a, identified a larger population of cells adherent on CTB (comparable to pFN-adherent cells) and dramatically increased the proportion of cells capable of forming neurites without reducing the time requirement.	G(M1) Ganglioside	44-47	chitobiase	Homo sapiens	115-118
3104072-5	1987	In ultrastructural studies using the scanning electron microscope (SEM) and immunofluorescence (IF) analyses to discriminate microtubule distributions, neurites of GM1-supplemented cells on CTB were virtually identical with pFN-adherent neurites, whereas unsupplemented cells on CTB generated processes with fine-structural differences.	G(M1) Ganglioside	164-167	chitobiase	Homo sapiens	190-193
3104072-6	1987	Treatment of cells during the GM1 supplementation period with cycloheximide completely abolished the ability of cells to generate neurites on CTB and decreased the adhesive capacity of cells as well; a similar treatment of cells had no adverse effect on adherence or neurite extension on pFN.	G(M1) Ganglioside	30-33	chitobiase	Homo sapiens	142-145
3104072-7	1987	The importance of one or more proteins in GM1-dependent processes was further confirmed by demonstrating the trypsin sensitivity of a cell surface component(s) required to achieve maximal attachment on CTB; in contrast, adherence and neurite extension on pFN were much more resistant to this treatment process.	G(M1) Ganglioside	42-45	chitobiase	Homo sapiens	202-205
3111543-4	1987	Lactosylsphingosine beta-galactosidase activities assayed in the absence and the presence of taurocholate (probably lactosylceramidase I) were deficient in fibroblasts from patients with globoid cell leukodystrophy, while the activity assayed with sodium cholate (probably lactosylceramidase II) was deficient in GM1 gangliosidosis fibroblasts.	G(M1) Ganglioside	313-316	galactosidase beta 1	Homo sapiens	20-38
3035998-0	1987	Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease.	G(M1) Ganglioside	16-31	galactosidase beta 1	Homo sapiens	32-50
3035998-2	1987	Utilizing a specific inactivator of the lysosomal enzyme GM1-ganglioside beta-galactosidase (beta-D-galactopyranosylmethyl-p-nitrophenyltriazene [beta-GalMNT]) and neuroblastoma X glioma hybrid cells (NG108-15), we suppressed beta-galactosidase activity for up to 72 hours.	G(M1) Ganglioside	57-72	galactosidase beta 1	Homo sapiens	73-91
3035998-2	1987	Utilizing a specific inactivator of the lysosomal enzyme GM1-ganglioside beta-galactosidase (beta-D-galactopyranosylmethyl-p-nitrophenyltriazene [beta-GalMNT]) and neuroblastoma X glioma hybrid cells (NG108-15), we suppressed beta-galactosidase activity for up to 72 hours.	G(M1) Ganglioside	57-72	galactosidase beta 1	Homo sapiens	226-244
2948673-1	1987	The present study was undertaken to examine the differential expression of asialo GM1 (AsGM1) on the responding cells and effectors of alloreactive cytotoxic T lymphocytes (CTL) and lymphokine-induced activated killers (LAK).	G(M1) Ganglioside	82-85	I-kappaB kinase beta	Drosophila melanogaster	182-218
3100448-10	1987	Moreover, treatment of PEC with monoclonal anti-Thy-1 antibody or with anti-asialo GM1 antiserum plus complement eliminated the production of IFN-gamma and the NK-like activity simultaneously, whereas treatment with monoclonal anti-Lyt-2 antibody plus complement did not.	G(M1) Ganglioside	83-86	interferon gamma	Mus musculus	142-151
3100448-11	1987	These results suggest that IL-2 and some unidentified factor released from plastic-adherent cells by LPS stimulation cooperatively induce IFN-gamma production in activated, Thy-1- and asialo GM1-positive NK-like cells appearing in inflammatory reactions and that prostaglandin E2 regulates IFN-gamma production in these cells.	G(M1) Ganglioside	191-194	interleukin 2	Mus musculus	27-31
3100448-11	1987	These results suggest that IL-2 and some unidentified factor released from plastic-adherent cells by LPS stimulation cooperatively induce IFN-gamma production in activated, Thy-1- and asialo GM1-positive NK-like cells appearing in inflammatory reactions and that prostaglandin E2 regulates IFN-gamma production in these cells.	G(M1) Ganglioside	191-194	interferon gamma	Mus musculus	138-147
3445796-0	1987	Analysis of the time course of GM1 ganglioside effect on changes in choline acetyltransferase activity in partially denervated rat hippocampus.	G(M1) Ganglioside	31-46	choline O-acetyltransferase	Rattus norvegicus	68-93
3493209-7	1987	In addition, the injection of anti-asialo GM1 antibody also depleted most of the non-specific killer cells induced by administering rIL-2.	G(M1) Ganglioside	42-45	interleukin 2	Rattus norvegicus	132-137
3493209-9	1987	Our results indicate that asialo GM1-positive cells play an important role as anti-metastatic effector cells in suppressing the metastasis of 3LL cells in mice given rIL-2.	G(M1) Ganglioside	33-36	interleukin 2	Rattus norvegicus	166-171
3033257-3	1987	At 14 and 18 days postlesion, histochemical staining showed that acetylcholinesterase (AChE) was almost completely eliminated in the hippocampus ipsilateral to the transection in untreated and GM1-treated rats.	G(M1) Ganglioside	193-196	acetylcholinesterase	Rattus norvegicus	65-85
3033257-3	1987	At 14 and 18 days postlesion, histochemical staining showed that acetylcholinesterase (AChE) was almost completely eliminated in the hippocampus ipsilateral to the transection in untreated and GM1-treated rats.	G(M1) Ganglioside	193-196	acetylcholinesterase	Rattus norvegicus	87-91
3033257-5	1987	Rather, there were significant reductions of AChE and choline acetyltransferase activities in the ipsilateral hippocampus relative to the contralateral value (P less than .001); and the reductions were greater in GM1-treated rats than in untreated controls (P less than .001).	G(M1) Ganglioside	213-216	acetylcholinesterase	Rattus norvegicus	45-49
3033257-5	1987	Rather, there were significant reductions of AChE and choline acetyltransferase activities in the ipsilateral hippocampus relative to the contralateral value (P less than .001); and the reductions were greater in GM1-treated rats than in untreated controls (P less than .001).	G(M1) Ganglioside	213-216	choline O-acetyltransferase	Rattus norvegicus	54-79
3827882-0	1986	A triple-binding-domain model explains the specificity of the interaction of a sphingolipid activator protein (SAP-1) with sulphatide, GM1-ganglioside and globotriaosylceramide.	G(M1) Ganglioside	135-150	prosaposin	Homo sapiens	111-116
3093471-0	1986	Multiplicity of bovine liver GM1 ganglioside beta-galactosidase.	G(M1) Ganglioside	29-32	galactosidase beta 1	Bos taurus	45-63
3489769-6	1986	The precursors of both the LAK cells and the cells bearing the cytolysin are eliminated by treatment with anti-asialo-GM1 and complement, strongly suggesting that the actual LAK effector cells and the cytolysin-bearing cells are identical.	G(M1) Ganglioside	118-121	perforin 1 (pore forming protein)	Mus musculus	63-72
3489769-6	1986	The precursors of both the LAK cells and the cells bearing the cytolysin are eliminated by treatment with anti-asialo-GM1 and complement, strongly suggesting that the actual LAK effector cells and the cytolysin-bearing cells are identical.	G(M1) Ganglioside	118-121	perforin 1 (pore forming protein)	Mus musculus	201-210
3092133-4	1986	Therefore, the adult disorder must be due to a mutation of the structural gene for beta-galactosidase, which is allelic to the mutations in type 1 GM1 gangliosidosis and Morquio B syndrome.	G(M1) Ganglioside	147-150	galactosidase beta 1	Homo sapiens	83-101
3489533-1	1986	Pretreatment of mice with rabbit anti-asialo GM1 removes both natural killer (NK) effector cells and NK cells responsive to interleukin 2 (IL-2).	G(M1) Ganglioside	45-48	interleukin 2	Mus musculus	124-137
3489533-1	1986	Pretreatment of mice with rabbit anti-asialo GM1 removes both natural killer (NK) effector cells and NK cells responsive to interleukin 2 (IL-2).	G(M1) Ganglioside	45-48	interleukin 2	Mus musculus	139-143
3093471-3	1986	Three forms of acid beta-galactosidase were separated by Sephadex G-200 gel filtration and the elution pattern of the 4-methylumbelliferyl-beta-galactosidase activity coincided with that of the GM1-beta-galactosidase activity.	G(M1) Ganglioside	194-197	galactosidase beta 1	Bos taurus	20-38
3730833-2	1986	It was found that the enhancement of recovery of acetylcholinesterase, choline acetyltransferase and serotonin uptake by GM1 treatment (30 mg/kg i.m., daily), as studied on the 6th and 21st postlesion day, was dependent on the degree of fiber degeneration.	G(M1) Ganglioside	121-124	acetylcholinesterase	Rattus norvegicus	49-69
3711664-3	1986	This difference was ascribed mainly to the increased susceptibility of H-2- cells to attack by natural effector mechanisms, particularly asialo GM1+ NK cells.	G(M1) Ganglioside	144-147	anon-H2	Drosophila melanogaster	71-74
3711664-4	1986	After treatment with both anti-asialo GM1 serum and whole body irradiation (400 rad), numerous colonies of H-2- cells formed in the lung, whereas the metastasis was only marginally enhanced by irradiation and moderately by treatment with anti-asialo GM1 serum.	G(M1) Ganglioside	38-41	anon-H2	Drosophila melanogaster	107-110
3711664-6	1986	Therefore collaboration of asialo GM1+ NK cells and radiosensitive natural effectors seems to be the main mechanism involved in the synergistic effects on defense against H-2- cell metastasis, and to a lesser extent against H-2+ cell metastasis.	G(M1) Ganglioside	34-37	anon-H2	Drosophila melanogaster	171-174
3711664-8	1986	On the other hand, treatment with anti-asialo GM1 serum increased colonization in the early phase of metastasis with H-2- cells and may have abolished asialo GM1+ NK cells capable of recognizing the reduced expression of H-2 antigens and eliminating H-2- cells in the blood-born phase.	G(M1) Ganglioside	46-49	anon-H2	Drosophila melanogaster	117-120
3711664-8	1986	On the other hand, treatment with anti-asialo GM1 serum increased colonization in the early phase of metastasis with H-2- cells and may have abolished asialo GM1+ NK cells capable of recognizing the reduced expression of H-2 antigens and eliminating H-2- cells in the blood-born phase.	G(M1) Ganglioside	46-49	anon-H2	Drosophila melanogaster	221-224
3730833-2	1986	It was found that the enhancement of recovery of acetylcholinesterase, choline acetyltransferase and serotonin uptake by GM1 treatment (30 mg/kg i.m., daily), as studied on the 6th and 21st postlesion day, was dependent on the degree of fiber degeneration.	G(M1) Ganglioside	121-124	choline O-acetyltransferase	Rattus norvegicus	71-96
3960319-0	1986	Gangliosides GM1 and GD1b are antigens for IgM M-protein in a patient with motor neuron disease.	G(M1) Ganglioside	13-16	myomesin 2	Homo sapiens	47-56
3711664-8	1986	On the other hand, treatment with anti-asialo GM1 serum increased colonization in the early phase of metastasis with H-2- cells and may have abolished asialo GM1+ NK cells capable of recognizing the reduced expression of H-2 antigens and eliminating H-2- cells in the blood-born phase.	G(M1) Ganglioside	46-49	anon-H2	Drosophila melanogaster	221-224
3711664-8	1986	On the other hand, treatment with anti-asialo GM1 serum increased colonization in the early phase of metastasis with H-2- cells and may have abolished asialo GM1+ NK cells capable of recognizing the reduced expression of H-2 antigens and eliminating H-2- cells in the blood-born phase.	G(M1) Ganglioside	158-161	anon-H2	Drosophila melanogaster	221-224
3711664-8	1986	On the other hand, treatment with anti-asialo GM1 serum increased colonization in the early phase of metastasis with H-2- cells and may have abolished asialo GM1+ NK cells capable of recognizing the reduced expression of H-2 antigens and eliminating H-2- cells in the blood-born phase.	G(M1) Ganglioside	158-161	anon-H2	Drosophila melanogaster	221-224
3524865-3	1986	ChAT-positive neurons also were stained for ganglioside GM1 by using an avidin-biotin complex technique.	G(M1) Ganglioside	56-59	choline O-acetyltransferase	Rattus norvegicus	0-4
3086209-5	1986	Fibroblasts from different types of galactosialidosis, a recessive disease associated with a coexistent beta-galactosidase/neuraminidase deficiency all showed degradation of ingested GM1.	G(M1) Ganglioside	183-186	galactosidase beta 1	Homo sapiens	104-122
3086209-5	1986	Fibroblasts from different types of galactosialidosis, a recessive disease associated with a coexistent beta-galactosidase/neuraminidase deficiency all showed degradation of ingested GM1.	G(M1) Ganglioside	183-186	neuraminidase 1	Homo sapiens	123-136
2870120-2	1986	Thy-1+ dEC lack other typical T cell markers such as L3T4, Lyt-1, and Lyt-2; however they do express Ly-5 and asialo GM1 in common with NK cells and certain other leukocytes.	G(M1) Ganglioside	117-120	thymus cell antigen 1, theta	Mus musculus	0-5
2870120-2	1986	Thy-1+ dEC lack other typical T cell markers such as L3T4, Lyt-1, and Lyt-2; however they do express Ly-5 and asialo GM1 in common with NK cells and certain other leukocytes.	G(M1) Ganglioside	117-120	defective chorion 1	Drosophila melanogaster	7-10
3088498-7	1986	Treatment with exo-beta-galactosidase transformed the trisaccharide OS II into the disaccharide OS I, indicating that the deficiency of beta-galactosidase in GM1 gangliosidosis type I, but not in type II, also affects glycoprotein catabolism, leading to the accumulation of glycopeptides containing terminal beta-galactosyl residues and N-acetyllactosamine repeating units.	G(M1) Ganglioside	158-161	galactosidase beta 1	Homo sapiens	19-37
3960319-4	1986	IgM-binding to the two gangliosides was detectable by ELISA at serum dilutions of greater than 1:10,000, and the M-protein was selectively immunoabsorbed by liposomes containing GM1 or GD1b.	G(M1) Ganglioside	178-181	myomesin 2	Homo sapiens	113-122
3960319-5	1986	The IgM M-protein also bound to asialo-GM1, indicating reactivity to the galactosyl(beta 1-3)N-acetylgalactosaminyl moiety shared by GM1, GD1b, and asialo-GM1.	G(M1) Ganglioside	39-42	myomesin 2	Homo sapiens	8-17
3960319-5	1986	The IgM M-protein also bound to asialo-GM1, indicating reactivity to the galactosyl(beta 1-3)N-acetylgalactosaminyl moiety shared by GM1, GD1b, and asialo-GM1.	G(M1) Ganglioside	39-42	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	84-92
3960319-5	1986	The IgM M-protein also bound to asialo-GM1, indicating reactivity to the galactosyl(beta 1-3)N-acetylgalactosaminyl moiety shared by GM1, GD1b, and asialo-GM1.	G(M1) Ganglioside	38-42	myomesin 2	Homo sapiens	8-17
3960319-5	1986	The IgM M-protein also bound to asialo-GM1, indicating reactivity to the galactosyl(beta 1-3)N-acetylgalactosaminyl moiety shared by GM1, GD1b, and asialo-GM1.	G(M1) Ganglioside	38-42	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	84-92
3941320-7	1986	The GM1-induced increase was evident at higher serum concentrations (1%) regardless of the presence or absence of NGF, but not apparent in low (0.15%) serum.	G(M1) Ganglioside	4-7	nerve growth factor	Rattus norvegicus	114-117
3947670-6	1986	Furthermore, the activity of GQ1b was completely abolished by neuraminidase treatment, which converted GQ1b to GM1, so we examined other molecular species of gangliosides having a common gangliotetraose backbone but linked differently with two to four sialic acids (i.e., GD1a, GD1b, GT1a, GT1b, GQ1b and GQ1c).	G(M1) Ganglioside	111-114	neuraminidase 1	Homo sapiens	62-75
3706712-5	1986	The content of ganglioside sialidase in human fibroblasts cultured in 75-cm2 plastic flasks was 5.8 +/- 2.5 (SD) nmol liberated GM1 h-1 mg protein-1.	G(M1) Ganglioside	128-131	neuraminidase 3	Homo sapiens	15-36
2418024-8	1986	However, GM3 and, to a much lower extent, GM1 were capable of inhibiting EGF-stimulated phosphorylation of the EGF receptor in membrane preparations of both KB and A431 cells.	G(M1) Ganglioside	42-45	epidermal growth factor receptor	Homo sapiens	111-123
3943547-3	1986	Above a critical ganglioside concentration, the gangliosides bound the fibronectin (GT1b congruent to GD1b congruent to GD1a greater than GM1 much greater than GM2 congruent to GD3 congruent to GM3) in approximately the same order of efficiency as they competed for the cellular sites of fibronectin binding in cell attachment assays (Kleinman et al., Proc natl acad sci US 76 (1979) 3367).	G(M1) Ganglioside	138-141	fibronectin 1	Rattus norvegicus	71-82
3943547-5	1986	Rat erythrocytes coated with gangliosides GM1, GD1a or GT1b bound more fibronectin than erythrocytes not supplemented with gangliosides.	G(M1) Ganglioside	42-45	fibronectin 1	Rattus norvegicus	71-82
3941320-10	1986	For all constituents stimulated by GM1, concurrent treatment with NGF produces cumulative effects, suggesting independent mechanisms of action by the two molecules.	G(M1) Ganglioside	35-38	nerve growth factor	Rattus norvegicus	66-69
3932335-6	1985	Acceptor specificity studies indicated that the purified alpha 1----3-galactosyltransferase was free from contaminating galactosyltransferase activities such as those involved in the synthesis of Gal beta 1----4GlcNAc-R and Gal beta 1----3GalNAc-R sequences, the blood group B determinant, the Pk antigen, trihexosylceramide, and ganglioside GM1.	G(M1) Ganglioside	342-345	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	57-91
3940213-4	1986	When the tumor load was greater or when IFN treatment was shorter, treatment with anti-asialo-GM1 partially abrogated the inhibition of tumor growth by IFN.	G(M1) Ganglioside	94-97	interferon alpha 1	Homo sapiens	40-43
3940213-4	1986	When the tumor load was greater or when IFN treatment was shorter, treatment with anti-asialo-GM1 partially abrogated the inhibition of tumor growth by IFN.	G(M1) Ganglioside	94-97	interferon alpha 1	Homo sapiens	152-155
3028990-0	1986	Immunocytochemical localization of sphingolipid activator protein-1, the sulfatide/GM1 ganglioside activator, to lysosomes in human liver and colon.	G(M1) Ganglioside	83-98	prosaposin	Homo sapiens	35-67
3028990-3	1986	In this study we sought immunocytochemical verification of the lysosomal location of SAP-1, a SAP that stimulates the hydrolysis of sulfatide and GM1 ganglioside.	G(M1) Ganglioside	146-161	prosaposin	Homo sapiens	85-90
2415273-2	1985	With a previously reported, simple and sensitive fluorometric assay for GM1 ganglioside beta-galactosidase using high performance liquid chromatography (HPLC), optimal reaction conditions were determined for the assay of acid beta-galactosidase activity toward asialofetuin in skin fibroblast homogenates.	G(M1) Ganglioside	72-87	galactosidase beta 1	Homo sapiens	88-106
2415273-2	1985	With a previously reported, simple and sensitive fluorometric assay for GM1 ganglioside beta-galactosidase using high performance liquid chromatography (HPLC), optimal reaction conditions were determined for the assay of acid beta-galactosidase activity toward asialofetuin in skin fibroblast homogenates.	G(M1) Ganglioside	72-87	galactosidase beta 1	Homo sapiens	226-244
3934152-6	1985	The purified beta-galactosidase had galactosylceramidase II activity, which was competitively inhibited by GM1 ganglioside.	G(M1) Ganglioside	107-122	galactosidase beta 1	Homo sapiens	13-31
3934152-7	1985	Thus, galactosylceramidase II seems to be identical to GM1 ganglioside beta-galactosidase and lactosylceramidase II.	G(M1) Ganglioside	55-70	galactosidase beta 1	Homo sapiens	71-89
3877776-8	1985	When mice were pretreated with anti-asialo GM1 antiserum, known to depress natural killer (NK) cell activity, the difference in outgrowth was abolished, and both the control line and the H-2- variant showed progressive growth in vivo.	G(M1) Ganglioside	43-46	histocompatibility-2, MHC	Mus musculus	187-190
4072495-1	1985	In this work the possibility of using neuraminidase for increasing the content of ganglioside GM1 in the mixture of gangliosides used for the sensitization of erythrocytes has been studied.	G(M1) Ganglioside	82-97	neuraminidase 1	Homo sapiens	38-51
3899934-5	1985	Moreover, the anti-YAC-1 lytic activity was partially sensitive to anti-Thy1.2 serum and was completely abrogated by treatment of peritoneal nonadherent cells with monoclonal anti-asialo GM1 antibodies.	G(M1) Ganglioside	187-190	ADP-ribosyltransferase 1	Mus musculus	19-24
2412585-1	1985	The interaction of myelin basic protein with monosialoganglioside GM1 was investigated.	G(M1) Ganglioside	66-69	myelin basic protein	Homo sapiens	19-39
2861245-8	1985	Thy-1+ cells also lacked differentiation antigens of most other types of leukocytes, except they were rich in asialo GM1.	G(M1) Ganglioside	117-120	thymus cell antigen 1, theta	Mus musculus	0-5
2409184-4	1985	Thy-1+dEC expressed both asialo GM1 and a cell surface determinant recognized by the monoclonal antibody 20-10-5S, further suggesting their functions will be included among those normally ascribed to lymphoreticular cells.	G(M1) Ganglioside	32-35	thymus cell antigen 1, theta	Mus musculus	0-5
2409185-9	1985	The surface marker repertoire of dThy-1+EC (Thy-1, Ly-5, asialo-GM1) resembles certain members of the rather heterogeneous natural killer (NK) cell system but functional studies are needed to ascertain this contention.	G(M1) Ganglioside	64-67	thymus cell antigen 1, theta	Mus musculus	34-39
3873347-2	1985	Because ganglioside GM1 is a component of the CT receptor, the present study was undertaken to determine whether gangliosides interact with CSF and therefore might play a role in the binding sites for CSF.	G(M1) Ganglioside	20-23	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	140-143
3873347-2	1985	Because ganglioside GM1 is a component of the CT receptor, the present study was undertaken to determine whether gangliosides interact with CSF and therefore might play a role in the binding sites for CSF.	G(M1) Ganglioside	20-23	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	201-204
3873347-7	1985	Four different individual gangliosides (GM1, GM2, GD1a, GT1b) were tested for their inhibitory effect on CSF-induced clonal growth of CFU-C. GM1 was the most effective with a 50% inhibition (I50) of clonal growth at a concentration of 15 microM.	G(M1) Ganglioside	40-43	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	105-108
3873347-7	1985	Four different individual gangliosides (GM1, GM2, GD1a, GT1b) were tested for their inhibitory effect on CSF-induced clonal growth of CFU-C. GM1 was the most effective with a 50% inhibition (I50) of clonal growth at a concentration of 15 microM.	G(M1) Ganglioside	141-144	cytochrome b5 domain containing 2	Mus musculus	45-48
3873347-7	1985	Four different individual gangliosides (GM1, GM2, GD1a, GT1b) were tested for their inhibitory effect on CSF-induced clonal growth of CFU-C. GM1 was the most effective with a 50% inhibition (I50) of clonal growth at a concentration of 15 microM.	G(M1) Ganglioside	141-144	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	105-108
3873347-10	1985	These data indicate that GM1 interacts with CSF and suggest that gangliosides may play a role in the interaction of CSF with CFU-C and that the binding site for CSF on the surface of these cells might either consist of or contain this ganglioside.	G(M1) Ganglioside	25-28	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	44-47
3873347-10	1985	These data indicate that GM1 interacts with CSF and suggest that gangliosides may play a role in the interaction of CSF with CFU-C and that the binding site for CSF on the surface of these cells might either consist of or contain this ganglioside.	G(M1) Ganglioside	25-28	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	116-119
3873347-10	1985	These data indicate that GM1 interacts with CSF and suggest that gangliosides may play a role in the interaction of CSF with CFU-C and that the binding site for CSF on the surface of these cells might either consist of or contain this ganglioside.	G(M1) Ganglioside	25-28	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	116-119
3922773-7	1985	Some of the IL 2 receptor-positive cells but Thy-1-negative cells reacted with anti-asialo GM1, a marker of the immature thymocytes.	G(M1) Ganglioside	91-94	interleukin 2	Mus musculus	12-16
3922773-7	1985	Some of the IL 2 receptor-positive cells but Thy-1-negative cells reacted with anti-asialo GM1, a marker of the immature thymocytes.	G(M1) Ganglioside	91-94	thymus cell antigen 1, theta	Mus musculus	45-50
3980013-1	1985	SAP-1 is a sphingolipid activator protein found in human tissues required for the enzymatic hydrolysis of GM1 ganglioside and sulfatide.	G(M1) Ganglioside	106-121	prosaposin	Homo sapiens	0-5
3919160-0	1985	Ganglioside GM1 does not initiate, but enhances neurite regeneration of nerve growth factor-dependent sensory neurones.	G(M1) Ganglioside	0-15	nerve growth factor	Homo sapiens	72-91
3919160-3	1985	However, the simultaneous presence of GM1 (100 micrograms/ml) and NGF (0.5-5 ng/ml) throughout a 5-day period of culture resulted in an enhancement of previously reported NGF-induced increases in the expression of neurofilament protein.	G(M1) Ganglioside	38-41	nerve growth factor	Homo sapiens	171-174
3919160-4	1985	Further, the addition of GM1 (0-200 micrograms/ml) at 48 h in vitro to cultures initially established in the presence of 5 ng/ml NGF substantially increased the subsequent expression of neurofilament protein, this response being both independent of and not potentiated by NGF.	G(M1) Ganglioside	25-28	nerve growth factor	Homo sapiens	129-132
3919160-4	1985	Further, the addition of GM1 (0-200 micrograms/ml) at 48 h in vitro to cultures initially established in the presence of 5 ng/ml NGF substantially increased the subsequent expression of neurofilament protein, this response being both independent of and not potentiated by NGF.	G(M1) Ganglioside	25-28	nerve growth factor	Homo sapiens	272-275
3989384-1	1985	A new procedure is described for preparing the molecular species of GM1 ganglioside that carry a single fatty acid (myristic (C14:0), stearic (C18:0), arachidic (C20:0) or lignoceric (C24:0) acid) and a single long chain base (C18 or C20 sphingosine, C18 or C20 sphinganine, each of them in natural 3D(+)erythro or unnatural 3L(-)threo form).	G(M1) Ganglioside	68-83	Bardet-Biedl syndrome 9	Homo sapiens	143-146
3989384-1	1985	A new procedure is described for preparing the molecular species of GM1 ganglioside that carry a single fatty acid (myristic (C14:0), stearic (C18:0), arachidic (C20:0) or lignoceric (C24:0) acid) and a single long chain base (C18 or C20 sphingosine, C18 or C20 sphinganine, each of them in natural 3D(+)erythro or unnatural 3L(-)threo form).	G(M1) Ganglioside	68-83	Bardet-Biedl syndrome 9	Homo sapiens	227-230
3989384-1	1985	A new procedure is described for preparing the molecular species of GM1 ganglioside that carry a single fatty acid (myristic (C14:0), stearic (C18:0), arachidic (C20:0) or lignoceric (C24:0) acid) and a single long chain base (C18 or C20 sphingosine, C18 or C20 sphinganine, each of them in natural 3D(+)erythro or unnatural 3L(-)threo form).	G(M1) Ganglioside	68-83	Bardet-Biedl syndrome 9	Homo sapiens	227-230
3871210-11	1985	Treatment of CE-2 TB lymphocytes with various antibody and C, with 2000 rad gamma-irradiation, or fractionation on Percoll density gradients suggested that radioresistant functions of Thy-1.2+, Lyt-1.2+, Lyt-2.2- and of asialo GM1+ cells are independently involved in LATI induction.	G(M1) Ganglioside	227-230	catalase activity, kidney	Mus musculus	13-17
6435528-1	1984	Sphingolipid activator protein-1 (SAP-1) is a glycoprotein found in human tissue extracts that stimulates the enzymatic hydrolysis of at least two glycosphingolipids, including GM1 ganglioside and sulfatide.	G(M1) Ganglioside	177-192	prosaposin	Homo sapiens	0-32
2939302-5	1985	Gc2/Gc1 + Gc2 with Gc1 = GAC + GAC1 and Gc2 = GM + GM1, GAC and GM being the dependent conductances on amniotic cavity (AC) and maternal (M) sides; GAC1 and GM1 being the leak conductances on AC and M. Gp and Gc are due to epithelial cell layer and Gs (conductance in a series) is due to the other layers.	G(M1) Ganglioside	51-54	solute carrier family 25 member 18	Homo sapiens	0-3
2939302-5	1985	Gc2/Gc1 + Gc2 with Gc1 = GAC + GAC1 and Gc2 = GM + GM1, GAC and GM being the dependent conductances on amniotic cavity (AC) and maternal (M) sides; GAC1 and GM1 being the leak conductances on AC and M. Gp and Gc are due to epithelial cell layer and Gs (conductance in a series) is due to the other layers.	G(M1) Ganglioside	51-54	olfactomedin 4	Homo sapiens	4-7
2939302-5	1985	Gc2/Gc1 + Gc2 with Gc1 = GAC + GAC1 and Gc2 = GM + GM1, GAC and GM being the dependent conductances on amniotic cavity (AC) and maternal (M) sides; GAC1 and GM1 being the leak conductances on AC and M. Gp and Gc are due to epithelial cell layer and Gs (conductance in a series) is due to the other layers.	G(M1) Ganglioside	157-160	solute carrier family 25 member 18	Homo sapiens	0-3
2939302-5	1985	Gc2/Gc1 + Gc2 with Gc1 = GAC + GAC1 and Gc2 = GM + GM1, GAC and GM being the dependent conductances on amniotic cavity (AC) and maternal (M) sides; GAC1 and GM1 being the leak conductances on AC and M. Gp and Gc are due to epithelial cell layer and Gs (conductance in a series) is due to the other layers.	G(M1) Ganglioside	157-160	olfactomedin 4	Homo sapiens	4-7
2939302-5	1985	Gc2/Gc1 + Gc2 with Gc1 = GAC + GAC1 and Gc2 = GM + GM1, GAC and GM being the dependent conductances on amniotic cavity (AC) and maternal (M) sides; GAC1 and GM1 being the leak conductances on AC and M. Gp and Gc are due to epithelial cell layer and Gs (conductance in a series) is due to the other layers.	G(M1) Ganglioside	157-160	solute carrier family 25 member 18	Homo sapiens	10-13
2939302-5	1985	Gc2/Gc1 + Gc2 with Gc1 = GAC + GAC1 and Gc2 = GM + GM1, GAC and GM being the dependent conductances on amniotic cavity (AC) and maternal (M) sides; GAC1 and GM1 being the leak conductances on AC and M. Gp and Gc are due to epithelial cell layer and Gs (conductance in a series) is due to the other layers.	G(M1) Ganglioside	157-160	solute carrier family 25 member 18	Homo sapiens	10-13
2939302-5	1985	Gc2/Gc1 + Gc2 with Gc1 = GAC + GAC1 and Gc2 = GM + GM1, GAC and GM being the dependent conductances on amniotic cavity (AC) and maternal (M) sides; GAC1 and GM1 being the leak conductances on AC and M. Gp and Gc are due to epithelial cell layer and Gs (conductance in a series) is due to the other layers.	G(M1) Ganglioside	157-160	ankyrin repeat domain 12	Homo sapiens	148-152
6395727-8	1984	Results indicated that ATS reacted with T-lymphocytes, and ABAT antiserum reacted with T-lymphocytes, with ABAT-T-positive cells, and with antiasialo GM1-positive cells The ABAT-T and asialo GM1 antisera reacted with the same cell populations, but did not react with ATS-positive cells and ABAT-positive cells.	G(M1) Ganglioside	150-153	4-aminobutyrate aminotransferase	Canis lupus familiaris	59-63
6435528-1	1984	Sphingolipid activator protein-1 (SAP-1) is a glycoprotein found in human tissue extracts that stimulates the enzymatic hydrolysis of at least two glycosphingolipids, including GM1 ganglioside and sulfatide.	G(M1) Ganglioside	177-192	prosaposin	Homo sapiens	34-39
6435528-2	1984	The ability of purified SAP-1 to stimulate GM1 ganglioside hydrolysis by extracts of cultured fibroblasts from patients with beta-galactosidase deficiency was examined, and all patients had a pronounced deficiency (under 10% of control).	G(M1) Ganglioside	43-58	prosaposin	Homo sapiens	24-29
6435528-10	1984	When SAP-1 from GM1 gangliosidosis liver was treated sequentially with neuraminidase, beta-galactosidase, and endoglycosidase D, almost all of it was converted to the forms found in control human liver.	G(M1) Ganglioside	16-19	prosaposin	Homo sapiens	5-10
6435528-10	1984	When SAP-1 from GM1 gangliosidosis liver was treated sequentially with neuraminidase, beta-galactosidase, and endoglycosidase D, almost all of it was converted to the forms found in control human liver.	G(M1) Ganglioside	16-19	neuraminidase 1	Homo sapiens	71-84
6435528-10	1984	When SAP-1 from GM1 gangliosidosis liver was treated sequentially with neuraminidase, beta-galactosidase, and endoglycosidase D, almost all of it was converted to the forms found in control human liver.	G(M1) Ganglioside	16-19	galactosidase beta 1	Homo sapiens	86-104
6477558-2	1984	Autoradiography after the binding of HNK-1 to thin-layer chromatograms of peripheral nerve gangliosides followed by radioiodinated goat anti-mouse IgM revealed that HNK-1 was reacting with a minor ganglioside that chromatographed between GM1 and GD1a.	G(M1) Ganglioside	238-241	beta-1,3-glucuronyltransferase 1	Homo sapiens	165-170
6435475-0	1984	A fluorometric microassay procedure for monitoring the enzymatic activity of GM1-ganglioside beta-galactosidase by use of high-performance liquid chromatography.	G(M1) Ganglioside	77-80	galactosidase beta 1	Homo sapiens	93-111
6432371-0	1984	Application of a GM1 ganglioside beta-galactosidase microassay method to diagnosis of GM1 gangliosidosis.	G(M1) Ganglioside	17-20	galactosidase beta 1	Homo sapiens	33-51
6432371-1	1984	The enzymatic diagnosis of GM1 gangliosidosis, including the diagnosis of heterozygosity, requires a microassay of GM1 ganglioside beta-galactosidase activity in lymphocytes and cultured skin fibroblasts.	G(M1) Ganglioside	115-130	galactosidase beta 1	Homo sapiens	131-149
6432371-3	1984	Reaction conditions were examined to determine those optimal for the assay of GM1 ganglioside beta-galactosidase activity in lymphocyte and skin fibroblast homogenates.	G(M1) Ganglioside	78-93	galactosidase beta 1	Homo sapiens	94-112
6435475-1	1984	For the measurement of the enzymatic activity of GM1-ganglioside (II3 NeuAcGgOse4Cer, galactosyl-N-acetylgalactosaminyl-(N-acetylneuraminosyl) galactosyl-glucosylceramide) beta-galactosidase in crude enzyme samples, a microassay using nonradioisotopic GM1-ganglioside was devised.	G(M1) Ganglioside	49-64	galactosidase beta 1	Homo sapiens	172-190
6142756-2	1984	GM1 treatment partially prevented the decrease of tyrosine hydroxylase (TH) activity caused by hemitransection in the substantia nigra ipsilateral to the lesion.	G(M1) Ganglioside	0-3	tyrosine hydroxylase	Rattus norvegicus	50-70
6747465-1	1984	A semi-preparative, analytical high performance liquid chromatographic (HPLC) procedure is described for the isolation of molecular species of GM1 and GD1a gangliosides containing a single long chain base, C18 or C20 sphingosine, C18 or C20 sphinganine, each in its natural erythro or unnatural threo form.	G(M1) Ganglioside	143-146	Bardet-Biedl syndrome 9	Homo sapiens	206-209
6747465-1	1984	A semi-preparative, analytical high performance liquid chromatographic (HPLC) procedure is described for the isolation of molecular species of GM1 and GD1a gangliosides containing a single long chain base, C18 or C20 sphingosine, C18 or C20 sphinganine, each in its natural erythro or unnatural threo form.	G(M1) Ganglioside	143-146	Bardet-Biedl syndrome 9	Homo sapiens	230-233
6747465-6	1984	All the individual molecular species of GM1 and GD1a gangliosides were also prepared in radioactive form by selective tritiation at C-3 of the long chain base.	G(M1) Ganglioside	40-43	complement C3	Homo sapiens	132-135
6200137-4	1984	The influence of myelin basic protein on the thermotropic behaviour of GM1 was also studied.	G(M1) Ganglioside	71-74	myelin basic protein	Homo sapiens	17-37
6232275-8	1984	Me-GM1 and HO-GM1 could be hydrolyzed by human hepatic beta-galactosidase in the presence of GM1-activator at rates comparable to that of the native GM1.	G(M1) Ganglioside	3-6	galactosidase beta 1	Homo sapiens	55-73
6232275-8	1984	Me-GM1 and HO-GM1 could be hydrolyzed by human hepatic beta-galactosidase in the presence of GM1-activator at rates comparable to that of the native GM1.	G(M1) Ganglioside	14-17	galactosidase beta 1	Homo sapiens	55-73
6142756-2	1984	GM1 treatment partially prevented the decrease of tyrosine hydroxylase (TH) activity caused by hemitransection in the substantia nigra ipsilateral to the lesion.	G(M1) Ganglioside	0-3	tyrosine hydroxylase	Rattus norvegicus	72-74
6142756-4	1984	In particular, chronic treatment with GM1 prevented the disappearance of TH-positive cell bodies in the substantia nigra and induced the appearance of longer TH-positive dendrites with respect to the saline treatment.	G(M1) Ganglioside	38-41	tyrosine hydroxylase	Rattus norvegicus	73-75
6142756-4	1984	In particular, chronic treatment with GM1 prevented the disappearance of TH-positive cell bodies in the substantia nigra and induced the appearance of longer TH-positive dendrites with respect to the saline treatment.	G(M1) Ganglioside	38-41	tyrosine hydroxylase	Rattus norvegicus	158-160
6134282-5	1983	When 150 micrograms of purified activator protein for GM1 ganglioside beta-galactosidase and sulfatide sulfatase was added in 4 ml of medium with the 14C-labeled sulfatide, correction of the sulfatide metabolism to the normal range was found.	G(M1) Ganglioside	54-57	galactosidase beta 1	Homo sapiens	70-88
6230401-3	1984	The cells participating in SCF production were absent from normal thymocytes and were present in BALB/c nu/nu spleen, were nonadherent, asialo GM1+, and bore low levels of Thy-1.2.	G(M1) Ganglioside	143-147	kit ligand	Mus musculus	27-30
6363308-3	1984	Inhibition of NK activity by treatment of mice with anti-asialo GM1 serum abrogated the antimetastatic effects of PGI2 or heparin.	G(M1) Ganglioside	64-67	prostaglandin I receptor (IP)	Mus musculus	114-118
6741741-2	1984	GM1 treatment favoured the collateral sprouting of dopaminergic axons in the striatum as indicated by the induced increase of tyrosine hydroxylase (TH) activity and immunofluorescence.	G(M1) Ganglioside	0-3	tyrosine hydroxylase	Rattus norvegicus	126-146
6741741-2	1984	GM1 treatment favoured the collateral sprouting of dopaminergic axons in the striatum as indicated by the induced increase of tyrosine hydroxylase (TH) activity and immunofluorescence.	G(M1) Ganglioside	0-3	tyrosine hydroxylase	Rattus norvegicus	148-150
6741741-3	1984	Concomitantly GM1 partially prevented the decrease of TH activity caused by the hemitransection in the substantia nigra ipsilateral to the lesion.	G(M1) Ganglioside	14-17	tyrosine hydroxylase	Rattus norvegicus	54-56
6741741-4	1984	A significant increase of TH immunoreactivity was also detected in the substantia nigra: GM1 prevented the disappearance of TH-positive cell bodies and increased the formation of TH-positive collaterals and dendrites with respect to the saline treatment.	G(M1) Ganglioside	89-92	tyrosine hydroxylase	Rattus norvegicus	26-28
6741741-4	1984	A significant increase of TH immunoreactivity was also detected in the substantia nigra: GM1 prevented the disappearance of TH-positive cell bodies and increased the formation of TH-positive collaterals and dendrites with respect to the saline treatment.	G(M1) Ganglioside	89-92	tyrosine hydroxylase	Rattus norvegicus	124-126
6741741-4	1984	A significant increase of TH immunoreactivity was also detected in the substantia nigra: GM1 prevented the disappearance of TH-positive cell bodies and increased the formation of TH-positive collaterals and dendrites with respect to the saline treatment.	G(M1) Ganglioside	89-92	tyrosine hydroxylase	Rattus norvegicus	124-126
6209415-2	1984	Titration of MBP by GM1 resulted in 13C NMR signal shifts for the I1e and His residues of MBP at a GM1/MBP mole ratio of one or less.	G(M1) Ganglioside	20-23	myelin basic protein	Homo sapiens	13-16
6209415-2	1984	Titration of MBP by GM1 resulted in 13C NMR signal shifts for the I1e and His residues of MBP at a GM1/MBP mole ratio of one or less.	G(M1) Ganglioside	20-23	myelin basic protein	Homo sapiens	90-93
6209415-2	1984	Titration of MBP by GM1 resulted in 13C NMR signal shifts for the I1e and His residues of MBP at a GM1/MBP mole ratio of one or less.	G(M1) Ganglioside	20-23	myelin basic protein	Homo sapiens	90-93
6209415-2	1984	Titration of MBP by GM1 resulted in 13C NMR signal shifts for the I1e and His residues of MBP at a GM1/MBP mole ratio of one or less.	G(M1) Ganglioside	99-102	myelin basic protein	Homo sapiens	13-16
6209415-2	1984	Titration of MBP by GM1 resulted in 13C NMR signal shifts for the I1e and His residues of MBP at a GM1/MBP mole ratio of one or less.	G(M1) Ganglioside	99-102	myelin basic protein	Homo sapiens	90-93
6209415-2	1984	Titration of MBP by GM1 resulted in 13C NMR signal shifts for the I1e and His residues of MBP at a GM1/MBP mole ratio of one or less.	G(M1) Ganglioside	99-102	myelin basic protein	Homo sapiens	90-93
6209415-8	1984	However, as the GM1/MBP mole ratio was increased to eight or greater a major conformational change of MBP was detected.	G(M1) Ganglioside	16-19	myelin basic protein	Homo sapiens	102-105
6209415-9	1984	An upfield shift of the GM1 midchain methylene resonance was observed for the GM1/MBP complex.	G(M1) Ganglioside	24-27	myelin basic protein	Homo sapiens	82-85
6209415-9	1984	An upfield shift of the GM1 midchain methylene resonance was observed for the GM1/MBP complex.	G(M1) Ganglioside	78-81	myelin basic protein	Homo sapiens	82-85
6209415-10	1984	This observation provides strong evidence that the state of GM1 interacting with MBP is different from that of GM1 micelles.	G(M1) Ganglioside	60-63	myelin basic protein	Homo sapiens	81-84
6209415-11	1984	The number of saturable GM1 binding sites on MBP is estimated to be four.	G(M1) Ganglioside	24-27	myelin basic protein	Homo sapiens	45-48
6209415-13	1984	Interaction of MBP with the oligosaccharide derived from GM1 was found to be weaker than with GM1.	G(M1) Ganglioside	57-60	myelin basic protein	Homo sapiens	15-18
6209415-13	1984	Interaction of MBP with the oligosaccharide derived from GM1 was found to be weaker than with GM1.	G(M1) Ganglioside	94-97	myelin basic protein	Homo sapiens	15-18
6209415-14	1984	Based on our data, a model for the interaction can be proposed: the first GM1 molecule is bound to the protein molecule through its head group and hydrocarbon chains, followed by the formation of a GM1/MBP complex with a concomitant conformational change of MBP as more GM1 is added.	G(M1) Ganglioside	74-77	myelin basic protein	Homo sapiens	202-205
6209415-14	1984	Based on our data, a model for the interaction can be proposed: the first GM1 molecule is bound to the protein molecule through its head group and hydrocarbon chains, followed by the formation of a GM1/MBP complex with a concomitant conformational change of MBP as more GM1 is added.	G(M1) Ganglioside	74-77	myelin basic protein	Homo sapiens	258-261
6209415-14	1984	Based on our data, a model for the interaction can be proposed: the first GM1 molecule is bound to the protein molecule through its head group and hydrocarbon chains, followed by the formation of a GM1/MBP complex with a concomitant conformational change of MBP as more GM1 is added.	G(M1) Ganglioside	198-201	myelin basic protein	Homo sapiens	202-205
6209415-14	1984	Based on our data, a model for the interaction can be proposed: the first GM1 molecule is bound to the protein molecule through its head group and hydrocarbon chains, followed by the formation of a GM1/MBP complex with a concomitant conformational change of MBP as more GM1 is added.	G(M1) Ganglioside	198-201	myelin basic protein	Homo sapiens	258-261
6209415-14	1984	Based on our data, a model for the interaction can be proposed: the first GM1 molecule is bound to the protein molecule through its head group and hydrocarbon chains, followed by the formation of a GM1/MBP complex with a concomitant conformational change of MBP as more GM1 is added.	G(M1) Ganglioside	198-201	myelin basic protein	Homo sapiens	202-205
6209415-14	1984	Based on our data, a model for the interaction can be proposed: the first GM1 molecule is bound to the protein molecule through its head group and hydrocarbon chains, followed by the formation of a GM1/MBP complex with a concomitant conformational change of MBP as more GM1 is added.	G(M1) Ganglioside	198-201	myelin basic protein	Homo sapiens	258-261
6502755-0	1984	Interaction of GM1 ganglioside with PC12 pheochromocytoma cells: serum- and NGF-dependent effects on neuritic growth (and proliferation).	G(M1) Ganglioside	15-30	nerve growth factor	Rattus norvegicus	76-79
6502755-7	1984	Serum exhibited a concentration-dependent inhibitory influence (lag) on NGF-induced neuritic recruitment, which was abolished by GM1.	G(M1) Ganglioside	129-132	nerve growth factor	Rattus norvegicus	72-75
6502758-1	1984	The effect of intramuscular administration of monosialoganglioside (GM1) on postlesion responses of choline acetyltransferase and acetylcholinesterase activity in partially deafferented rat hippocampus was studied at various survival times.	G(M1) Ganglioside	68-71	choline O-acetyltransferase	Rattus norvegicus	100-125
6502758-1	1984	The effect of intramuscular administration of monosialoganglioside (GM1) on postlesion responses of choline acetyltransferase and acetylcholinesterase activity in partially deafferented rat hippocampus was studied at various survival times.	G(M1) Ganglioside	68-71	acetylcholinesterase	Rattus norvegicus	130-150
6671979-0	1983	Expression of GM1 and GD1a in mouse liver is linked to the H-2 complex on chromosome 17.	G(M1) Ganglioside	14-17	histocompatibility-2, MHC	Mus musculus	59-62
6171919-0	1981	Expression of asialo GM1 by both Thy-1-positive and Thy-1-negative lymphocytes: evidence for modification of asialo GM1 by sialic acid.	G(M1) Ganglioside	21-24	Thy-1 cell surface antigen	Homo sapiens	33-38
6600260-7	1983	Further, F.1 cells treated with anti-asialo GM1 antibody and C, from which NK cells and cytolytic activity were almost completely abrogated and for which T cells were enriched, conversely formed a few IL 2-dependent colonies.	G(M1) Ganglioside	44-47	interleukin 2	Mus musculus	201-205
6416742-0	1983	A beta-galactosidase isoenzyme from Turbo cornutus with substrate specificity toward GM1-ganglioside and glycoproteins.	G(M1) Ganglioside	85-100	galactosidase beta 1	Homo sapiens	2-20
6416742-7	1983	The optimal conditions for the hydrolysis of the terminal galactose from GM1-ganglioside which does not occur in gastropods, such as T. cornutus, was found to require 40 mM NaCl and 1 mM sodium taurodeoxycholate at pH 3.0 in 50 mM sodium citrate buffer, conditions similar to those by mammalian beta-galactosidase.	G(M1) Ganglioside	73-88	galactosidase beta 1	Homo sapiens	295-313
6964400-3	1982	Affinity-purified rabbit anti-GM1 antibodies were found to block the sprouting from dorsal root ganglia (DRG) of chicken embryo induced by nerve growth factor (NGF).	G(M1) Ganglioside	30-33	nerve growth factor	Gallus gallus	139-158
6964400-3	1982	Affinity-purified rabbit anti-GM1 antibodies were found to block the sprouting from dorsal root ganglia (DRG) of chicken embryo induced by nerve growth factor (NGF).	G(M1) Ganglioside	30-33	nerve growth factor	Gallus gallus	160-163
6964400-6	1982	These results emphasize the high resolution of the system and suggest that the interaction of NGF with GM1 is involved in the process of sprouting.	G(M1) Ganglioside	103-106	nerve growth factor	Gallus gallus	94-97
7172413-3	1982	Neuraminidase treatments caused a time- and dose-related release of sialic acid from the cells and enhanced the stimulatory effect of cholera toxin on basal and TPA-induced ODC activities as much as the monosialoganglioside GM1.	G(M1) Ganglioside	224-227	neuraminidase 1	Homo sapiens	0-13
6947236-6	1981	Cytolysis of both NKR and NKS lines was mediated by nylon-nonadherent asialo-GM1+ effector cells, and effectors from poly(I) .	G(M1) Ganglioside	77-80	tachykinin receptor 3	Mus musculus	18-21
6811570-1	1982	1) Two forms of acid beta-galactosidase [EC 3.1.23] with different molecular weights catalyzing the hydrolysis of GM1-ganglioside and p-nitrophenyl-beta-D-galactoside were separated and purified from porcine spleen.	G(M1) Ganglioside	114-129	galactosidase beta 1	Homo sapiens	21-39
6807121-4	1982	However, the amount of the brain GM1-ganglioside was accumulated to a less degree in comparison with that of typical type 2 GM1-gangliosidosis, though the activity of GM1-beta-galactosidase in the brain was deficient to the same degree as in the typical case.	G(M1) Ganglioside	33-48	galactosidase beta 1	Homo sapiens	171-189
6171919-0	1981	Expression of asialo GM1 by both Thy-1-positive and Thy-1-negative lymphocytes: evidence for modification of asialo GM1 by sialic acid.	G(M1) Ganglioside	21-24	Thy-1 cell surface antigen	Homo sapiens	52-57
6171919-2	1981	The results presented herein demonstrate that 55-57% of Thy-1.2-positive cells in spleen and 61-70% of Thy-1.2-positive cells in lymph node express asialo GM1.	G(M1) Ganglioside	155-158	Thy-1 cell surface antigen	Homo sapiens	56-61
6171919-2	1981	The results presented herein demonstrate that 55-57% of Thy-1.2-positive cells in spleen and 61-70% of Thy-1.2-positive cells in lymph node express asialo GM1.	G(M1) Ganglioside	155-158	Thy-1 cell surface antigen	Homo sapiens	103-108
6171919-3	1981	Furthermore, a significant frequency of Thy-1-negative cells in spleen (12-19%) and in  lymph node (28-32%) also express asialo GM1.	G(M1) Ganglioside	128-131	Thy-1 cell surface antigen	Homo sapiens	40-45
6171919-6	1981	Pretreatment of lymphocytes from spleen, thymus and lymph node with neuraminidase resulted in subsequent reactivity of 80-90% of these cells with anti-asialo GM1 anti-bodies.	G(M1) Ganglioside	158-161	neuraminidase 1	Homo sapiens	68-81
6171919-7	1981	A smaller increase in asialo GM1 detection after neuraminidase treatment was seen with bone-marrow cells (65%).	G(M1) Ganglioside	29-32	neuraminidase 1	Homo sapiens	49-62
7240748-3	1981	Intravenous injection of anti-asialo GM1, which has been shown to eliminate natural killer (NK) activity in vitro in the presence of complement, completely abolished NK activity against lymphoma cell line (YAC-1) in spleen cells from athymic nude mice as well as from conventional mice.	G(M1) Ganglioside	37-40	ADP-ribosyltransferase 1	Mus musculus	206-211
6787458-3	1981	GM1 gangliosidosis was diagnosed by absence of beta-galactosidase activity in leukocytes and fibroblasts.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	47-65
6968778-6	1980	These results suggest that asialo GM1 is present on very early thymocytes and is lost as the mature murine T cell protein antigens Thy-1, Lyt-1, and Lyt-2 develop on these cells.	G(M1) Ganglioside	34-37	thymus cell antigen 1, theta	Mus musculus	131-136
7014713-11	1980	The data indicated that the number of cryptic GM1 and/or higher gangliosides exposed by neuraminidase in the cell membrane varied during cell differentiation and was directly related to specific cell types.	G(M1) Ganglioside	46-49	neuraminidase 1	Homo sapiens	88-101
6778205-1	1980	The residual liver acid beta-galactosidase activity from the first documented case of GM1 gangliosidosis in dogs was partially purified and characterized with respect to kinetic properties, thermostability, isoelectric point, molecular weight, and antigenicity.	G(M1) Ganglioside	86-89	galactosidase beta 1	Canis lupus familiaris	24-42
6778205-2	1980	The GM1 dog liver beta-galactosidase appears to be identical with the normal dog liver enzyme in all properties examined.	G(M1) Ganglioside	4-7	galactosidase beta 1	Canis lupus familiaris	18-36
6784662-2	1981	Certain genetic and biochemical studies have suggested that the phenotypic variation found in GM1 gangliosidosis results from different allelic mutations affecting the GM1 ganglioside beta-galactosidase locus and that different combinations of these mutations accounts for the clinical heterogeneity of this illness.	G(M1) Ganglioside	94-97	galactosidase beta 1	Homo sapiens	184-202
6784662-2	1981	Certain genetic and biochemical studies have suggested that the phenotypic variation found in GM1 gangliosidosis results from different allelic mutations affecting the GM1 ganglioside beta-galactosidase locus and that different combinations of these mutations accounts for the clinical heterogeneity of this illness.	G(M1) Ganglioside	168-171	galactosidase beta 1	Homo sapiens	184-202
6784662-3	1981	A family in which both the infantile and juvenile forms of GM1 gangliosidosis occurred, the children sharing a common mutation of their acid beta-galactosidase activity, supports the allelic nature of these different clinical forms of the disease.	G(M1) Ganglioside	59-62	galactosidase beta 1	Homo sapiens	141-159
6784663-2	1981	The residual acid beta-galactosidase in the juvenile form of GM1 gangliosidosis has three bands of enzyme activity with an apparent isoelectric pH (pI) range from 4.9 to 5.2, whereas that in the infantile form has a single band with an apparent pI of 5.2.	G(M1) Ganglioside	61-64	galactosidase beta 1	Homo sapiens	18-36
6784663-3	1981	Separation of residual acid beta-galactosidase into multiple molecular forms by analytical isoelectric focusing demonstrates enzymatic differences that can be correlated with the allelic mutations that affect the GM1 ganglioside beta-galactosidase locus.	G(M1) Ganglioside	213-228	galactosidase beta 1	Homo sapiens	28-46
6784663-3	1981	Separation of residual acid beta-galactosidase into multiple molecular forms by analytical isoelectric focusing demonstrates enzymatic differences that can be correlated with the allelic mutations that affect the GM1 ganglioside beta-galactosidase locus.	G(M1) Ganglioside	213-228	galactosidase beta 1	Homo sapiens	229-247
6968778-6	1980	These results suggest that asialo GM1 is present on very early thymocytes and is lost as the mature murine T cell protein antigens Thy-1, Lyt-1, and Lyt-2 develop on these cells.	G(M1) Ganglioside	34-37	CD5 antigen	Mus musculus	138-143
6968778-6	1980	These results suggest that asialo GM1 is present on very early thymocytes and is lost as the mature murine T cell protein antigens Thy-1, Lyt-1, and Lyt-2 develop on these cells.	G(M1) Ganglioside	34-37	CD8 antigen, alpha chain	Mus musculus	149-154
6774976-0	1980	pH-dependent association-dissociation of GM1-beta-galactosidase purified from porcine spleen.	G(M1) Ganglioside	41-44	galactosidase beta 1	Homo sapiens	45-63
7460898-1	1980	The binding of ganglioside GM1 to bovine serum albumin has been studied by using absorption and fluorescence properties of the protein chromophores.	G(M1) Ganglioside	15-30	albumin	Homo sapiens	41-54
6257300-1	1980	Hydrolysis of ganglioside GM1 by Sendai virus neuraminidase.	G(M1) Ganglioside	14-29	neuraminidase 1	Homo sapiens	46-59
6257300-2	1980	The action of neuraminidase of influenza A virus, Sendai virus and Newcastle disease virus particles on bovine brain ganglioside GM1 and the properties of Sendai virus neuraminidase for GM1 were studied.	G(M1) Ganglioside	129-132	neuraminidase 1	Homo sapiens	14-27
6257300-2	1980	The action of neuraminidase of influenza A virus, Sendai virus and Newcastle disease virus particles on bovine brain ganglioside GM1 and the properties of Sendai virus neuraminidase for GM1 were studied.	G(M1) Ganglioside	186-189	neuraminidase 1	Homo sapiens	168-181
6257300-5	1980	The apparent Km of Sendai virus neuraminidase for GM1 hydrolysis was found to be 2.67 x 10(-4) M and the optimum pH was 5.6.	G(M1) Ganglioside	50-53	neuraminidase 1	Homo sapiens	32-45
6257300-8	1980	In the absence of the surfactant, Sendai virus neuraminidase hydrolyzed GM1 more efficiently than Arthobacter ureafaciens neuraminidase which has been reported recently as being an adequate enzyme to hydrolyze ganglioside GM1 as a substrate.	G(M1) Ganglioside	72-75	neuraminidase 1	Homo sapiens	47-60
6257300-8	1980	In the absence of the surfactant, Sendai virus neuraminidase hydrolyzed GM1 more efficiently than Arthobacter ureafaciens neuraminidase which has been reported recently as being an adequate enzyme to hydrolyze ganglioside GM1 as a substrate.	G(M1) Ganglioside	72-75	neuraminidase 1	Homo sapiens	122-135
6257300-8	1980	In the absence of the surfactant, Sendai virus neuraminidase hydrolyzed GM1 more efficiently than Arthobacter ureafaciens neuraminidase which has been reported recently as being an adequate enzyme to hydrolyze ganglioside GM1 as a substrate.	G(M1) Ganglioside	222-225	neuraminidase 1	Homo sapiens	47-60
6257300-8	1980	In the absence of the surfactant, Sendai virus neuraminidase hydrolyzed GM1 more efficiently than Arthobacter ureafaciens neuraminidase which has been reported recently as being an adequate enzyme to hydrolyze ganglioside GM1 as a substrate.	G(M1) Ganglioside	222-225	neuraminidase 1	Homo sapiens	122-135
7005403-1	1980	A radioassay for the rapid determination of GM1 ganglioside concentration in small volumes of CSF from individual patients is described.	G(M1) Ganglioside	44-59	colony stimulating factor 2	Homo sapiens	94-97
7005403-4	1980	The radioassay-determined lumbar CSF GM1 ganglioside concentrations in a small group of patients with diverse neurologic disorders are presented.	G(M1) Ganglioside	37-52	colony stimulating factor 2	Homo sapiens	33-36
6774976-1	1980	A beta-galactosidase [EC 3.1.23] catalyzing the hydrolysis of GM1-ganglioside was purified from porcine spleen to a homogeneous form.	G(M1) Ganglioside	62-77	galactosidase beta 1	Homo sapiens	2-20
6773584-7	1980	Since 80-90% of lactosylceramide-cleaving activity in normal fibroblasts is due to GM1-ganglioside beta-galactosidase and since fibroblasts of globoid cell leukodystrophy patients are genetically deficient in galactosylceramidase but normal in GM1-ganglioside beta-galactosidase, these rsults are also consistent with specific activation of galactosylceramidase by phosphatidylserine.	G(M1) Ganglioside	83-98	galactosidase beta 1	Homo sapiens	99-117
6446239-5	1980	Deficient beta-gal activity was observed toward p-nitrophenyl-beta-galactoside, 4-methylumbelliferyl-beta-galactoside (4 MU-beta-gal), lactose, GM1 ganglioside, keratan sulfate, and asialofetuin (ASF).	G(M1) Ganglioside	144-159	galactosidase beta 1	Homo sapiens	10-18
7395924-1	1980	Gm and Inv data--polymorphism for Gm3 and for Gm1,17,21 without Gm(26).	G(M1) Ganglioside	46-49	leishmanolysin like peptidase	Homo sapiens	7-10
6767344-2	1980	One of them, galactosylceramidase, is primarily responsible for degradation of galactosylceramide, galactosylsphingosine, and monogalactosyl-diglyceride, while the other, GM1-ganglioside beta-galactosidase, degrades GM1-ganglioside and asialo GM1-ganglioside.	G(M1) Ganglioside	171-186	galactosidase beta 1	Homo sapiens	187-205
81194-1	1978	The aim of the present study was to determine the relationship of the Thy-1 antigenic determinants to the cell surface ganglioside GM1.	G(M1) Ganglioside	131-134	thymus cell antigen 1, theta	Mus musculus	70-75
6778958-3	1980	Activity of PNP-beta-galactosidase in normal brain tissue, like that of cerebroside beta-galactosidase from the same source, was considerably more heat-stable than the activity of either 4-MU-beta-galactosidase or the predominant GM1 beta-D-galactosidase (EC 3.2.1.23).	G(M1) Ganglioside	230-233	galactosidase beta 1	Homo sapiens	16-34
6778958-4	1980	Lac-cer and GM1, as well as 4-MU-gal and PNP-gal, were competitive inhibitors of human-brain cerebroside beta-galactosidase.	G(M1) Ganglioside	12-15	galactosidase beta 1	Homo sapiens	105-123
115863-6	1979	In connection with the enzymic hydrolysis of GM1 and GM2, we found that the hydrolysis of GM2 by human hepatic beta-N-acetylhexosaminidase A was severely inhibited by a buffer of high ionic strength, whereas no such inhibition was observed in the hydrolysis of GM1 by beta-galactosidase.	G(M1) Ganglioside	45-48	galactosidase beta 1	Homo sapiens	268-286
117700-4	1979	beta-Galactosidase activity was deficient in cultured fibroblasts using [3H]GM1 ganglioside and [3H]ceramide-lactose as substrates.	G(M1) Ganglioside	76-91	galactosidase beta 1	Homo sapiens	0-18
226973-1	1979	Human beta-endorphin adopts a partial helical conformation in aqueous solutions of cerebroside sulfate, ganglioside GM1, phosphatidylserine, and phosphatidic acid, but not of cerebroside and phosphatidylcholine, as evidenced by circular dichroic spectra.	G(M1) Ganglioside	116-119	proopiomelanocortin	Homo sapiens	6-20
103801-3	1978	GM1-ganglioside beta-galactosidase activity was reduced to 1% of the control value in both the brain and liver of the affected fetus.	G(M1) Ganglioside	0-15	galactosidase beta 1	Homo sapiens	16-34
731265-8	1978	These findings are consistent with the known substrate specificities of the two acidic beta-galactosidases in human tissues; galactosylceramide is hydrolyzed almost exclusively by galactosylceramidase, while lactosylceramide can be hydrolyzed by both galactosylceramidase and GM1-ganglioside beta-galactosidase.	G(M1) Ganglioside	276-291	galactosidase beta 1	Homo sapiens	87-105
83795-1	1978	The residual liver acid beta-galactosidase (beta-gal) activity from a case of feline GM1 gangliosidosis was partially purified and characterized with respect to its pH optimum, kinetic properties, thermostability, isoelectric point, molecular weight, and antigenicity.	G(M1) Ganglioside	85-88	galactosidase beta 1	Homo sapiens	24-42
83795-1	1978	The residual liver acid beta-galactosidase (beta-gal) activity from a case of feline GM1 gangliosidosis was partially purified and characterized with respect to its pH optimum, kinetic properties, thermostability, isoelectric point, molecular weight, and antigenicity.	G(M1) Ganglioside	85-88	galactosidase beta 1	Homo sapiens	24-32
83795-4	1978	The results suggest that the mutation in the Birmingham GM1 cat is structural and that the residual enzyme activity is a structurally altered acid beta-gal.	G(M1) Ganglioside	56-59	galactosidase beta 1	Homo sapiens	147-155
413573-0	1978	Purification and characterization of GM1 ganglioside beta-galactosidase from normal feline liver and brain.	G(M1) Ganglioside	37-40	galactosidase beta 1	Homo sapiens	53-71
27879-0	1978	The abnormalities of beta-galactosidase in GM1-gangliosidoses.	G(M1) Ganglioside	43-46	galactosidase beta 1	Homo sapiens	21-39
27879-1	1978	The activity of GM1 beta-galactosidase in the brain and liver of patients with GM1-gangliosidosis was assayed using GM1-ganglioside tritiated in the terminal galactose.	G(M1) Ganglioside	16-19	galactosidase beta 1	Homo sapiens	20-38
27879-1	1978	The activity of GM1 beta-galactosidase in the brain and liver of patients with GM1-gangliosidosis was assayed using GM1-ganglioside tritiated in the terminal galactose.	G(M1) Ganglioside	116-131	galactosidase beta 1	Homo sapiens	20-38
79545-1	1978	The hypothesis that Thy-1.2 carries a carbohydrate antigenic determinant with the same specificity as the monosialoganglioside GM1 was tested by attempting to co-cap Thy-1.2 and GM1 in CBA thymocytes using anti-Thy-1.2 alloantiserum and cholera toxin.	G(M1) Ganglioside	178-181	thymus cell antigen 1, theta	Mus musculus	20-27
79545-3	1978	We do not therefore confirm the previous reported association between Thy-1 and GM1 (Thiele, Arndt & Stark, 1977).	G(M1) Ganglioside	80-83	thymus cell antigen 1, theta	Mus musculus	70-75
658424-0	1978	Susceptibility of ganglioside GM1 to a new bacterial neuraminidase.	G(M1) Ganglioside	30-33	neuraminidase 1	Homo sapiens	53-66
413573-1	1978	GM1 ganglioside beta-galactosidase (GM1-beta-galactosidase) was purified from normal cat brain and liver by a combination of classical and affinity procedures.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	16-34
413573-1	1978	GM1 ganglioside beta-galactosidase (GM1-beta-galactosidase) was purified from normal cat brain and liver by a combination of classical and affinity procedures.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	40-58
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	G(M1) Ganglioside	119-122	galactosidase beta 1	Homo sapiens	123-141
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	G(M1) Ganglioside	119-122	galactosidase beta 1	Homo sapiens	173-191
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	G(M1) Ganglioside	169-172	galactosidase beta 1	Homo sapiens	123-141
413573-7	1978	The apparent Km determined for 4-methylumbelliferyl beta-D-galactopyranoside (4-MU-Gal) using partially purified brain GM1-beta-galactosidase was 1.73 X 10(-4) M. Liver GM1-beta-galactosidase gave a Km with 4-MU-Gal of 3.25 X 10(-4) M and for [3H]GM1 ganglioside a Km of 4.51 X 10(-4) M was calculated.	G(M1) Ganglioside	247-262	galactosidase beta 1	Homo sapiens	123-141
404844-3	1977	The Fc, pFc", tFc", and peak IV fragments all interacted with a rheumatoid factor having anti-Gm(1) specificity and showed a reaction of identity in agar diffusion against both anti-Fc and anti-pFc" sera.	G(M1) Ganglioside	94-99	complement factor properdin	Homo sapiens	8-12
411612-0	1977	GM1-ganglioside beta-galactosidase in leukocytes and cultured fibroblasts.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	16-34
409573-2	1977	We have demonstrated complete inhibition of GM1 ganglioside beta-galactosidase activity in vitro by both heparan sulfate and dermatan sulfate, but the effect on lactosylceramide and galactosylceramide hydrolysis was less marked.	G(M1) Ganglioside	44-59	galactosidase beta 1	Homo sapiens	60-78
978233-1	1976	Cholera toxin was coupled to peroxidase to yield a highly specific marker for GM1 gangliosides.	G(M1) Ganglioside	78-94	Peroxidase	Drosophila melanogaster	29-39
13910-6	1977	Relative specific activities of GM1-ganglioside beta-galactosidase toward the same series of the substrates were 0.3, 78, 19, 100, 150 and 240; However, the optimal assay conditions for any given natural substrate were sufficiently different for each beta-galactosidase so that diagnostic assays for the two genetic diseases due to beta-galactosidase deficiencies could be carried out in whole tissues.	G(M1) Ganglioside	32-47	galactosidase beta 1	Homo sapiens	48-66
13910-6	1977	Relative specific activities of GM1-ganglioside beta-galactosidase toward the same series of the substrates were 0.3, 78, 19, 100, 150 and 240; However, the optimal assay conditions for any given natural substrate were sufficiently different for each beta-galactosidase so that diagnostic assays for the two genetic diseases due to beta-galactosidase deficiencies could be carried out in whole tissues.	G(M1) Ganglioside	32-47	galactosidase beta 1	Homo sapiens	251-269
962854-3	1976	It has the same ability to hydrolyse GM1 ganglioside as the two other acid beta-galactosidase forms.	G(M1) Ganglioside	37-52	galactosidase beta 1	Homo sapiens	75-93
824196-3	1976	The Hp1 gene ranges from 0.1557 to 0.2639; Gm1 is lower (0.34-0.55) than in other populations in Southern India.	G(M1) Ganglioside	43-46	chromobox 5	Homo sapiens	4-7
817853-2	1976	In fibroblasts, ganglioside GM1 beta-galactosidase activity averaged 7% of the normal mean while asialofetuin beta-galactosidase and 4-methylumbe lifery-beta-galactosidase averaged 1.4% and 3.5%, respectively.	G(M1) Ganglioside	16-31	galactosidase beta 1	Homo sapiens	32-50
817853-3	1976	Activities for all three substrates in leucocytes from both her parents were close to 50% of the normal mean indicating that the patient is homozygous for a mutation (or mutations) affecting GM1 beta-galactosidase.	G(M1) Ganglioside	191-194	galactosidase beta 1	Homo sapiens	195-213
814123-5	1976	The purified activator stimulates the hydrolysis of GM1 by beta-galactosidase, GM2 by beta-hexosaminidase, as well as ceramide trihexoside by alpha-galactosidase A or B.	G(M1) Ganglioside	52-55	galactosidase beta 1	Homo sapiens	59-77
821451-5	1975	In leukocytes, the activity of p-nitrophenyl-beta-galactosidase was below 5%, and that of GM1-ganglioside beta-galactosidase below 1% of values obtained in controls.	G(M1) Ganglioside	90-105	galactosidase beta 1	Homo sapiens	106-124
33673080-2	2021	Confocal microscopy revealed colocalization of PM-localized GnRH-R with GM1-enriched raft-like PM subdomains.	G(M1) Ganglioside	72-75	gonadotropin releasing hormone receptor	Homo sapiens	60-66
4214813-0	1974	GM1 ganglioside beta-galactosidase.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	16-34
4774399-0	1973	Hydrolysis of GM1-ganglioside by human liver beta-galactosidase isoenzymes.	G(M1) Ganglioside	14-29	galactosidase beta 1	Homo sapiens	45-63
4774399-2	1973	GM(1)-ganglioside, specifically tritiated in the terminal galactose, was hydrolysed by two forms of ;acid" methylumbelliferyl beta-galactosidase isolated on gel filtration.	G(M1) Ganglioside	0-17	galactosidase beta 1	Homo sapiens	126-144
4774399-4	1973	Identification of GM(1)-ganglioside beta-galactosidase activity with the ;acid" methyl-umbelliferyl beta-galactosidases was based on the following: coincident elution profiles on gel filtration; simultaneous inactivation by heat and other treatments; stabilization of both activities by chloride ions; mutual inhibition of hydrolysis by the two substrates.	G(M1) Ganglioside	18-35	galactosidase beta 1	Homo sapiens	36-54
4258708-0	1972	Leukocyte beta-galactosidase activity in the diagnosis of generalized GM 1  gangliosidosis.	G(M1) Ganglioside	70-74	galactosidase beta 1	Homo sapiens	10-28
33733293-0	2021	Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3beta Pathway.	G(M1) Ganglioside	21-24	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
33733293-0	2021	Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3beta Pathway.	G(M1) Ganglioside	21-24	glycogen synthase kinase 3 alpha	Rattus norvegicus	122-130
33733293-8	2021	To determine whether GM1 exerted its effect via the PI3K/AKT/GSK3beta pathway, PC12 cells were incubated with LY294002, a PI3K inhibitor.	G(M1) Ganglioside	21-24	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
33733293-8	2021	To determine whether GM1 exerted its effect via the PI3K/AKT/GSK3beta pathway, PC12 cells were incubated with LY294002, a PI3K inhibitor.	G(M1) Ganglioside	21-24	glycogen synthase kinase 3 alpha	Rattus norvegicus	61-69
33733293-9	2021	We found that GM1 protected against ketamine-induced apoptosis in the hippocampus and cortex by reducing the expression of Bcl-2 and Caspase-3, and by increasing the expression of Bax.	G(M1) Ganglioside	14-17	BCL2, apoptosis regulator	Rattus norvegicus	123-128
33733293-9	2021	We found that GM1 protected against ketamine-induced apoptosis in the hippocampus and cortex by reducing the expression of Bcl-2 and Caspase-3, and by increasing the expression of Bax.	G(M1) Ganglioside	14-17	caspase 3	Rattus norvegicus	133-142
33733293-9	2021	We found that GM1 protected against ketamine-induced apoptosis in the hippocampus and cortex by reducing the expression of Bcl-2 and Caspase-3, and by increasing the expression of Bax.	G(M1) Ganglioside	14-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	180-183
33733293-10	2021	GM1 treatment increased the expression of p-AKT and p-GSK3beta.	G(M1) Ganglioside	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
33733293-10	2021	GM1 treatment increased the expression of p-AKT and p-GSK3beta.	G(M1) Ganglioside	0-3	glycogen synthase kinase 3 alpha	Rattus norvegicus	54-62
33733293-11	2021	However, the anti-apoptotic effect of GM1 was eliminated after inhibiting the phosphorylation of AKT.	G(M1) Ganglioside	38-41	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
33733293-12	2021	We showed that GM1 lessens ketamine-induced apoptosis in the hippocampus and cortex of young rats by regulating the PI3K/AKT/GSK3beta pathway.	G(M1) Ganglioside	15-18	AKT serine/threonine kinase 1	Rattus norvegicus	121-124
33733293-12	2021	We showed that GM1 lessens ketamine-induced apoptosis in the hippocampus and cortex of young rats by regulating the PI3K/AKT/GSK3beta pathway.	G(M1) Ganglioside	15-18	glycogen synthase kinase 3 alpha	Rattus norvegicus	125-133
33612342-6	2021	The chimeric protein retained the biological activity of mGM-CSF and had stronger GM1 binding activity than (CTB-PSMA624-632)5.	G(M1) Ganglioside	82-85	chitobiase	Mus musculus	109-112
804170-6	1975	Beta-Galactosidase from the patient had a Km that was higher then normal; 5-fold higher with ganglioside GM1 and 2-fold higher with 4-methylumbelliferyl beta-galactoside.	G(M1) Ganglioside	105-108	galactosidase beta 1	Homo sapiens	0-18
33979140-7	2021	At the cellular level, OleA targets S100A9 amyloids already at the membranes as shown by immunofluorescence and fluorescence resonance energy transfer, significantly reducing the amyloid accumulation in GM1 ganglioside containing membrane rafts.	G(M1) Ganglioside	203-218	S100 calcium binding protein A9	Homo sapiens	36-42
33909305-10	2021	The postulation of four possible neuroplastin environments pointed to the GD1a ganglioside enrichment during reproductive senescence of stressed females, as well as its high dispersion in both regions and to GD1a and GM1 loss in the CA1 region.	G(M1) Ganglioside	217-220	neuroplastin	Rattus norvegicus	33-45
24156116-0	1993	GLB1-Related Disorders CLINICAL CHARACTERISTICS: GLB1-related disorders comprise two phenotypically distinct lysosomal storage disorders: GM1 gangliosidosis and mucopolysaccharidosis type IVB (MPS IVB).	G(M1) Ganglioside	138-141	galactosidase beta 1	Homo sapiens	0-4
24156116-0	1993	GLB1-Related Disorders CLINICAL CHARACTERISTICS: GLB1-related disorders comprise two phenotypically distinct lysosomal storage disorders: GM1 gangliosidosis and mucopolysaccharidosis type IVB (MPS IVB).	G(M1) Ganglioside	138-141	galactosidase beta 1	Homo sapiens	49-53
33859490-2	2021	Mutation of the GLB1 gene, which codes for beta-gal, prevents cleavage of the terminal beta-1,4-linked galactose residue from GM1 ganglioside.	G(M1) Ganglioside	126-141	galactosidase beta 1	Homo sapiens	16-20
33666366-8	2021	The antigenicity of the plant-made LTB-CdeM antigen was evidenced by GM1 ELISA and immunogenicity assessment performed in test mice revealed that the LTB-CdeM antigen is orally immunogenic inducing significant humoral responses against CdeM epitopes.	G(M1) Ganglioside	69-72	lymphotoxin B	Mus musculus	35-38
33666366-8	2021	The antigenicity of the plant-made LTB-CdeM antigen was evidenced by GM1 ELISA and immunogenicity assessment performed in test mice revealed that the LTB-CdeM antigen is orally immunogenic inducing significant humoral responses against CdeM epitopes.	G(M1) Ganglioside	69-72	exosporium morphogenetic protein CdeM	Clostridioides difficile	39-43
33511002-2	2021	In this study, a cerebrovascular-targeting multifunctional lipoprotein-biomimetic nanostructure (RAP-RL) constituted with an antagonist peptide (RAP) of receptor for advanced glycation end-products (RAGE), monosialotetrahexosyl ganglioside, and apolipoprotein E3 is developed to recover the functional NVU and normalize the cerebral vasculature.	G(M1) Ganglioside	206-239	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	97-100
32770506-5	2021	In addition, we also provide a detailed protocol for the visualization of the coclustering of Fas/CD95 death receptor and lipid rafts, as assessed by using anti-Fas/CD95 antibodies and fluorescent dye-conjugated cholera toxin B subunit that binds to ganglioside GM1, a main component of lipid rafts, by immunofluorescence and confocal microscopy.	G(M1) Ganglioside	250-265	Fas cell surface death receptor	Homo sapiens	98-102
32960582-1	2020	The canonical binding site on the B subunit of cholera toxin (CTB) binds to GM1 gangliosides on host cells.	G(M1) Ganglioside	76-92	phosphate cytidylyltransferase 1B, choline	Homo sapiens	62-65
33053147-1	2020	Using single-molecule imaging with enhanced time resolutions down to 5 ms, we found that CD59 cluster rafts and GM1 cluster rafts were stably induced in the outer leaflet of the plasma membrane (PM), which triggered the activation of Lyn, H-Ras, and ERK and continually recruited Lyn and H-Ras right beneath them in the inner leaflet with dwell lifetimes <0.1 s. The detection was possible due to the enhanced time resolutions employed here.	G(M1) Ganglioside	112-115	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	234-237
32846182-7	2020	Our results show that Abeta binds POPC bilayers, and that binding increases (DeltaG of binding decreases) with GM1, but only up to 3 mol% of the ganglioside, larger concentrations appearing to have a lower effect.	G(M1) Ganglioside	111-114	amyloid beta precursor protein	Homo sapiens	22-27
33201378-1	2020	Recently, we demonstrated that the oligosaccharide portion of ganglioside GM1 is responsible, via direct interaction and activation of the TrkA pathway, for the ability of GM1 to promote neuritogenesis and to confer neuroprotection in Neuro2a mouse neuroblastoma cells.	G(M1) Ganglioside	62-77	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	139-143
33201378-1	2020	Recently, we demonstrated that the oligosaccharide portion of ganglioside GM1 is responsible, via direct interaction and activation of the TrkA pathway, for the ability of GM1 to promote neuritogenesis and to confer neuroprotection in Neuro2a mouse neuroblastoma cells.	G(M1) Ganglioside	74-77	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	139-143
32779865-1	2020	BACKGROUND: In GM1 gangliosidosis the lack of function of beta-galactosidase results in an accumulation of GM1 ganglioside and related glycoconjugates in visceral organs, and particularly in the central nervous system, leading to severe disability and premature death.	G(M1) Ganglioside	15-18	galactosidase beta 1	Homo sapiens	58-76
32658599-4	2020	Mechanistically, human cathelicidin (LL-37), as an extracellular complex with LPS, interacted with lipid raft-associated GM1 gangliosides to internalize and activate intracellular TLR4.	G(M1) Ganglioside	121-137	cathelicidin antimicrobial peptide	Homo sapiens	37-42
32658599-4	2020	Mechanistically, human cathelicidin (LL-37), as an extracellular complex with LPS, interacted with lipid raft-associated GM1 gangliosides to internalize and activate intracellular TLR4.	G(M1) Ganglioside	121-137	toll like receptor 4	Homo sapiens	180-184
32779865-1	2020	BACKGROUND: In GM1 gangliosidosis the lack of function of beta-galactosidase results in an accumulation of GM1 ganglioside and related glycoconjugates in visceral organs, and particularly in the central nervous system, leading to severe disability and premature death.	G(M1) Ganglioside	107-122	galactosidase beta 1	Homo sapiens	58-76
32817933-13	2020	HCQ blocked both GM1 and PIP 2 domains ability to attract and cluster ACE2.	G(M1) Ganglioside	17-20	angiotensin converting enzyme 2	Homo sapiens	70-74
32820783-2	2020	We observed that HA1 preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA1 GM1 or GM3.	G(M1) Ganglioside	183-186	keratin 31	Homo sapiens	17-20
32916822-7	2020	GM1 has been shown to induce specific changes in the spatial organization of Abeta, which lead to enhanced peptide accumulation and deleterious effect especially on neuronal membranes containing clusters of this ganglioside.	G(M1) Ganglioside	0-3	amyloid beta precursor protein	Homo sapiens	77-82
32449563-6	2020	In the particular case of CTB, it allowed to reveal the existence of a hitherto unknown binding subsite adjacent to the GM1 binding pocket, paving the way to the design of novel leads for inhibition of this relevant toxin.	G(M1) Ganglioside	120-123	phosphate cytidylyltransferase 1B, choline	Homo sapiens	26-29
32719116-3	2020	We show that alpha-syn preferentially binds to GM1-rich, liquid-ordered lipid domains on cytoplasmic membranes by using unroofed cells, which encapsulates lipid complexity and cellular topology.	G(M1) Ganglioside	47-50	synuclein alpha	Homo sapiens	13-22
32142821-2	2020	Accumulating evidence, both in vivo and in vitro, suggests that the binding of Abeta to gangliosides, especially monosialoganglioside GM1, plays an important role in the aggregation of Abeta.	G(M1) Ganglioside	134-137	amyloid beta precursor protein	Homo sapiens	79-84
32142821-2	2020	Accumulating evidence, both in vivo and in vitro, suggests that the binding of Abeta to gangliosides, especially monosialoganglioside GM1, plays an important role in the aggregation of Abeta.	G(M1) Ganglioside	134-137	amyloid beta precursor protein	Homo sapiens	185-190
32599772-7	2020	Interestingly, by the exogenous administration of GM1, it becomes a component of the PM, reducing the destabilizing effect of the potentiator VX-770 on rescued CFTR protein expression/function and improving its stabilization.	G(M1) Ganglioside	50-53	CF transmembrane conductance regulator	Homo sapiens	160-164
32751790-4	2020	CTB binds specifically and with high affinity to exosomal GM1 ganglioside residing in rafts only, and it has long been the probe of choice for membrane rafts.	G(M1) Ganglioside	58-61	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-3
32915361-4	2020	Two recombinant polypeptides GM and GM1 capable of binding to alpha2-M were obtained using the G4223 strain of a group G Streptococcus, protein G molecule of which interacts with three human blood serum proteins (IgG, HSA, and alpha2-M).	G(M1) Ganglioside	36-39	alpha-2-macroglobulin	Homo sapiens	62-70
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	G(M1) Ganglioside	26-29	leptin receptor	Mus musculus	53-68
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	G(M1) Ganglioside	26-29	leptin receptor	Mus musculus	70-74
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	G(M1) Ganglioside	26-29	leptin receptor	Mus musculus	88-92
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	G(M1) Ganglioside	26-29	Janus kinase 2	Mus musculus	129-133
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	G(M1) Ganglioside	26-29	signal transducer and activator of transcription 3	Mus musculus	134-139
32477123-8	2020	One of the signaling pathways that may be involved in the activation of these proteases is the MAPK pathway, since phosphorylation of ERK1/2 was observed in cells treated with SMase D. Confocal analysis showed a strong colocalization between SMase D and GM1 ganglioside present in rafts.	G(M1) Ganglioside	254-257	mitogen-activated protein kinase 3	Homo sapiens	134-140
32134631-3	2020	Importantly, the CT B subunit (CTB) has a noncanonical site that binds fucosylated structures, which in contrast to GM1 are highly expressed in the human intestine.	G(M1) Ganglioside	116-119	phosphate cytidylyltransferase 1B, choline	Homo sapiens	17-21
32134631-3	2020	Importantly, the CT B subunit (CTB) has a noncanonical site that binds fucosylated structures, which in contrast to GM1 are highly expressed in the human intestine.	G(M1) Ganglioside	116-119	phosphate cytidylyltransferase 1B, choline	Homo sapiens	31-34
32252429-1	2020	GM1-gangliosidosis is caused by a reduced activity of beta-galactosidase (Glb1), resulting in intralysosomal accumulations of GM1.	G(M1) Ganglioside	0-3	galactosidase, beta 1	Mus musculus	54-72
32229586-8	2020	UGCG inhibition with the ceramide analog EtDO-P4 greatly reduced GSL and monosialotetrahexosylganglioside (GM1) levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis.	G(M1) Ganglioside	73-105	UDP-glucose ceramide glucosyltransferase	Homo sapiens	0-4
32229586-8	2020	UGCG inhibition with the ceramide analog EtDO-P4 greatly reduced GSL and monosialotetrahexosylganglioside (GM1) levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis.	G(M1) Ganglioside	107-110	UDP-glucose ceramide glucosyltransferase	Homo sapiens	0-4
32252429-1	2020	GM1-gangliosidosis is caused by a reduced activity of beta-galactosidase (Glb1), resulting in intralysosomal accumulations of GM1.	G(M1) Ganglioside	0-3	galactosidase, beta 1	Mus musculus	74-78
31934908-14	2020	CONCLUSIONS: Our data suggest that the exogenous GM1 acts on BDNF signaling pathway to ameliorate the cognitive impairment and hippocampal apoptosis induced by ketamine in young rats.	G(M1) Ganglioside	49-52	brain-derived neurotrophic factor	Rattus norvegicus	61-65
32111985-0	2021	Asialo GM1-positive liver-resident CD8 T cells that express CD44 and LFA-1 are essential for immune clearance of hepatitis B virus.	G(M1) Ganglioside	7-10	CD44 antigen	Mus musculus	60-64
32111985-0	2021	Asialo GM1-positive liver-resident CD8 T cells that express CD44 and LFA-1 are essential for immune clearance of hepatitis B virus.	G(M1) Ganglioside	7-10	integrin alpha L	Mus musculus	69-74
32101119-10	2020	GM1-ELISA assay indicated that plant LTB protein bound specifically to GM1-ganglioside, suggesting that the LTB subunits formed active pentamers.	G(M1) Ganglioside	0-3	lymphotoxin beta	Homo sapiens	37-40
31602645-5	2020	Co-immunoprecipitation analysis reveals a consistent association between PrPC and GM1, as well as between LRP1 and GM1, indicating the existence of a glycosphingolipid-enriched multimolecular complex.	G(M1) Ganglioside	82-85	prion protein	Homo sapiens	73-77
32477604-10	2020	The GM1 ganglioside presumably shielded MTX liposomes from phagocytosis by one of the monocyte populations and increased the efficiency of monocyte uptake by another population, probably one expressing C3b-binding receptors (C3b was detected on liposomes after incubation with blood plasma).	G(M1) Ganglioside	4-7	complement C3	Homo sapiens	202-205
32477604-10	2020	The GM1 ganglioside presumably shielded MTX liposomes from phagocytosis by one of the monocyte populations and increased the efficiency of monocyte uptake by another population, probably one expressing C3b-binding receptors (C3b was detected on liposomes after incubation with blood plasma).	G(M1) Ganglioside	4-7	complement C3	Homo sapiens	225-228
32101119-10	2020	GM1-ELISA assay indicated that plant LTB protein bound specifically to GM1-ganglioside, suggesting that the LTB subunits formed active pentamers.	G(M1) Ganglioside	0-3	lymphotoxin beta	Homo sapiens	108-111
32101119-10	2020	GM1-ELISA assay indicated that plant LTB protein bound specifically to GM1-ganglioside, suggesting that the LTB subunits formed active pentamers.	G(M1) Ganglioside	71-86	lymphotoxin beta	Homo sapiens	37-40
32101119-10	2020	GM1-ELISA assay indicated that plant LTB protein bound specifically to GM1-ganglioside, suggesting that the LTB subunits formed active pentamers.	G(M1) Ganglioside	71-86	lymphotoxin beta	Homo sapiens	108-111
32101119-11	2020	CONCLUSION: The s-ltb gene that was successfully transformed into centella plants by the biolistic method has produced a relatively high amount of plant LTB protein in the pentameric quaternary structure that has GM1-ganglioside binding affinity, a receptor on the intestinal epithelial membrane.	G(M1) Ganglioside	213-228	lymphotoxin beta	Homo sapiens	18-21
32101119-11	2020	CONCLUSION: The s-ltb gene that was successfully transformed into centella plants by the biolistic method has produced a relatively high amount of plant LTB protein in the pentameric quaternary structure that has GM1-ganglioside binding affinity, a receptor on the intestinal epithelial membrane.	G(M1) Ganglioside	213-228	lymphotoxin beta	Homo sapiens	153-156
30414004-0	2019	GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus.	G(M1) Ganglioside	0-3	sirtuin 1	Rattus norvegicus	88-93
31534909-0	2019	Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis.	G(M1) Ganglioside	112-127	galactosidase beta 1	Homo sapiens	6-10
31534909-0	2019	Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis.	G(M1) Ganglioside	112-127	galactosidase beta 1	Homo sapiens	81-85
31534909-7	2019	Analysis of GLB1 knockout organoids in culture revealed progressive accumulation of GM1 ganglioside.	G(M1) Ganglioside	84-99	galactosidase beta 1	Homo sapiens	12-16
31534909-8	2019	GLB1 knockout organoids microinjected with AAV9-GLB1 vector showed a significant increase in beta-gal activity and a significant reduction in GM1 ganglioside content compared with AAV9-GFP-injected organoids, demonstrating the efficacy of an AAV9 gene therapy-based approach in GM1 gangliosidosis.	G(M1) Ganglioside	142-157	galactosidase beta 1	Homo sapiens	0-4
31534909-8	2019	GLB1 knockout organoids microinjected with AAV9-GLB1 vector showed a significant increase in beta-gal activity and a significant reduction in GM1 ganglioside content compared with AAV9-GFP-injected organoids, demonstrating the efficacy of an AAV9 gene therapy-based approach in GM1 gangliosidosis.	G(M1) Ganglioside	142-157	galactosidase beta 1	Homo sapiens	48-52
31447771-6	2019	GM1 was shown to attenuate ischemic neuronal injuries in diabetes patients by suppression of ERK1/2 phosphorylation and reduction of stress to the endoplasmic reticulum.	G(M1) Ganglioside	0-3	mitogen-activated protein kinase 3	Homo sapiens	93-99
30414004-0	2019	GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus.	G(M1) Ganglioside	0-3	cAMP responsive element binding protein 1	Rattus norvegicus	94-98
30414004-0	2019	GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus.	G(M1) Ganglioside	0-3	brain-derived neurotrophic factor	Rattus norvegicus	99-103
30414004-7	2019	Moreover, GM1 counteracted lead-induced apoptosis by decreasing the expression of Bax, cleaved caspase-3, and by increasing the level of Bcl-2 in a dose-dependent manner.	G(M1) Ganglioside	10-13	BCL2 associated X, apoptosis regulator	Rattus norvegicus	82-85
30414004-7	2019	Moreover, GM1 counteracted lead-induced apoptosis by decreasing the expression of Bax, cleaved caspase-3, and by increasing the level of Bcl-2 in a dose-dependent manner.	G(M1) Ganglioside	10-13	BCL2, apoptosis regulator	Rattus norvegicus	137-142
30414004-8	2019	Furthermore, we found that GM1 upregulated the expression of SIRT1, CREB phosphorylation, and BDNF, which underlie learning and memory in the lead-treated developing rat hippocampus.	G(M1) Ganglioside	27-30	sirtuin 1	Rattus norvegicus	61-66
30414004-8	2019	Furthermore, we found that GM1 upregulated the expression of SIRT1, CREB phosphorylation, and BDNF, which underlie learning and memory in the lead-treated developing rat hippocampus.	G(M1) Ganglioside	27-30	cAMP responsive element binding protein 1	Rattus norvegicus	68-72
30414004-8	2019	Furthermore, we found that GM1 upregulated the expression of SIRT1, CREB phosphorylation, and BDNF, which underlie learning and memory in the lead-treated developing rat hippocampus.	G(M1) Ganglioside	27-30	brain-derived neurotrophic factor	Rattus norvegicus	94-98
30414004-9	2019	In conclusion, our study demonstrated that GM1 exerts a protective effect on lead-induced cognitive deficits via antioxidant activity, preventing apoptosis, and activating SIRT1/CREB/BDNF in the developing rat hippocampus, implying a novel potential assistant therapy for lead poisoning.	G(M1) Ganglioside	43-46	sirtuin 1	Rattus norvegicus	172-177
30414004-9	2019	In conclusion, our study demonstrated that GM1 exerts a protective effect on lead-induced cognitive deficits via antioxidant activity, preventing apoptosis, and activating SIRT1/CREB/BDNF in the developing rat hippocampus, implying a novel potential assistant therapy for lead poisoning.	G(M1) Ganglioside	43-46	cAMP responsive element binding protein 1	Rattus norvegicus	178-182
30414004-9	2019	In conclusion, our study demonstrated that GM1 exerts a protective effect on lead-induced cognitive deficits via antioxidant activity, preventing apoptosis, and activating SIRT1/CREB/BDNF in the developing rat hippocampus, implying a novel potential assistant therapy for lead poisoning.	G(M1) Ganglioside	43-46	brain-derived neurotrophic factor	Rattus norvegicus	183-187
31127673-0	2019	Ganglioside GM1 promotes contact inhibition of growth by regulating the localization of epidermal growth factor receptor from glycosphingolipid-enriched microdomain to caveolae.	G(M1) Ganglioside	12-15	epidermal growth factor receptor	Homo sapiens	88-120
31127673-5	2019	GM1 manipulation of cell proliferation and epidermal growth factor receptor (EGFR) activation was investigated by immunoprecipitation, OptiPrep density gradient centrifugation and immunofluorescence.	G(M1) Ganglioside	0-3	Epidermal growth factor receptor	Drosophila melanogaster	77-81
31127673-8	2019	Exogenous addition of GM1 to high-density cells clearly inhibited cell growth and deactivated EGFR signalling.	G(M1) Ganglioside	22-25	Epidermal growth factor receptor	Drosophila melanogaster	94-98
31127673-9	2019	Compared to normal-density cells, distribution of EGFR in high-density cells was decreased in glycosphingolipid-enriched microdomain (GEM), but more concentrated in caveolae, and incubation with GM1 obviously promoted this translocation.	G(M1) Ganglioside	195-198	epidermal growth factor receptor	Homo sapiens	50-54
31127673-10	2019	Furthermore, the cell growth and EGFR activation were increased in GM1 stably knockdown cells and decreased in GM1 stably overexpression cells when cultured in high density.	G(M1) Ganglioside	67-70	Epidermal growth factor receptor	Drosophila melanogaster	33-37
31127673-10	2019	Furthermore, the cell growth and EGFR activation were increased in GM1 stably knockdown cells and decreased in GM1 stably overexpression cells when cultured in high density.	G(M1) Ganglioside	111-114	Epidermal growth factor receptor	Drosophila melanogaster	33-37
31127673-11	2019	CONCLUSIONS: Our results demonstrated that GM1 suppressed EGFR signalling and promoted contact inhibition of growth by changing the localization of EGFR from GEM to caveolae.	G(M1) Ganglioside	43-46	epidermal growth factor receptor	Homo sapiens	58-62
31127673-11	2019	CONCLUSIONS: Our results demonstrated that GM1 suppressed EGFR signalling and promoted contact inhibition of growth by changing the localization of EGFR from GEM to caveolae.	G(M1) Ganglioside	43-46	epidermal growth factor receptor	Homo sapiens	148-152
31182727-0	2019	GM1 Ganglioside Modifies alpha-Synuclein Toxicity and is Neuroprotective in a Rat alpha-Synuclein Model of Parkinson"s Disease.	G(M1) Ganglioside	0-15	synuclein alpha	Rattus norvegicus	25-40
31182727-1	2019	While GM1 may interact with alpha-synuclein in vitro to inhibit aggregation, the ability of GM1 to protect against alpha-synuclein toxicity in vivo has not been investigated.	G(M1) Ganglioside	92-95	synuclein alpha	Rattus norvegicus	115-130
31182727-0	2019	GM1 Ganglioside Modifies alpha-Synuclein Toxicity and is Neuroprotective in a Rat alpha-Synuclein Model of Parkinson"s Disease.	G(M1) Ganglioside	0-15	synuclein alpha	Rattus norvegicus	82-97
32254998-8	2019	Moreover, we found that SeNPs@GM1/TMP could attenuate ROS overproduction to prevent mitochondria dysfunction via inhibiting the activation of p53 and MAPK pathways.	G(M1) Ganglioside	30-33	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	142-145
31182727-4	2019	Both types of GM1 administration protected against loss of SN dopamine neurons and striatal dopamine levels, reduced alpha-synuclein aggregation, and delayed start administration of GM1 reversed early appearing behavioral deficits.	G(M1) Ganglioside	14-17	synuclein alpha	Rattus norvegicus	117-132
31048748-2	2019	Recent studies showed that monosialotetrahexosylganglioside (GM1) clusters induce the pathological aggregation of Abeta peptide responsible for the onset and development of AD.	G(M1) Ganglioside	27-59	amyloid beta precursor protein	Homo sapiens	114-119
31048748-2	2019	Recent studies showed that monosialotetrahexosylganglioside (GM1) clusters induce the pathological aggregation of Abeta peptide responsible for the onset and development of AD.	G(M1) Ganglioside	61-64	amyloid beta precursor protein	Homo sapiens	114-119
31048748-4	2019	Interactions between Abeta peptide and GM1-glycan cluster is important for the earliest stage of the toxic aggregation on GM1 cluster.	G(M1) Ganglioside	39-42	amyloid beta precursor protein	Homo sapiens	21-26
30677149-1	2019	INTRODUCTION: In motor neurons, cholera toxin B (CTB) binds to the cell-surface ganglioside GM1 and is internalized and transported via structurally unique components of plasma membranes (lipid rafts).	G(M1) Ganglioside	80-95	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	32-47
30677149-1	2019	INTRODUCTION: In motor neurons, cholera toxin B (CTB) binds to the cell-surface ganglioside GM1 and is internalized and transported via structurally unique components of plasma membranes (lipid rafts).	G(M1) Ganglioside	80-95	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	49-52
30863991-3	2019	GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk).	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	30-49
30863991-3	2019	GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk).	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	51-54
30863991-3	2019	GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk).	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	106-109
30863991-3	2019	GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk).	G(M1) Ganglioside	0-3	nerve growth factor receptor	Rattus norvegicus	154-179
30863991-3	2019	GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk).	G(M1) Ganglioside	0-3	nerve growth factor receptor	Rattus norvegicus	181-187
30863991-3	2019	GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk).	G(M1) Ganglioside	0-3	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	219-224
30863991-3	2019	GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk).	G(M1) Ganglioside	0-3	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	226-229
30863991-3	2019	GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk).	G(M1) Ganglioside	0-3	nerve growth factor	Rattus norvegicus	106-109
30863991-3	2019	GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk).	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	320-323
30863991-7	2019	Finally, we tested if FUR insufficiency and/or p75NTR-mediated apoptosis negatively affect the neurotherapeutic effect of GM1.	G(M1) Ganglioside	122-125	nerve growth factor receptor	Rattus norvegicus	47-53
30863991-12	2019	GM1 increased FUR levels, while concomitant administration of EPI weakened GM1 effect on pro-survival Trk and p75NTR mediators.	G(M1) Ganglioside	0-3	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	14-17
30863991-12	2019	GM1 increased FUR levels, while concomitant administration of EPI weakened GM1 effect on pro-survival Trk and p75NTR mediators.	G(M1) Ganglioside	75-78	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	102-105
30863991-12	2019	GM1 increased FUR levels, while concomitant administration of EPI weakened GM1 effect on pro-survival Trk and p75NTR mediators.	G(M1) Ganglioside	75-78	nerve growth factor receptor	Rattus norvegicus	110-116
30863991-13	2019	GM1 neuroprotection is therefore not limited by FUR but could be dependent on p75NTR.	G(M1) Ganglioside	0-3	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	48-51
30863991-13	2019	GM1 neuroprotection is therefore not limited by FUR but could be dependent on p75NTR.	G(M1) Ganglioside	0-3	nerve growth factor receptor	Rattus norvegicus	78-84
31013778-6	2019	First, it was shown that increased GM1 levels associated with aging/senescence contribute to insulin resistance in human aortic endothelial cells (HAECs).	G(M1) Ganglioside	35-38	insulin	Homo sapiens	93-100
30611881-0	2019	siRNA-mediated knockdown of B3GALT4 decreases GM1 ganglioside expression and enhances vulnerability for neurodegeneration.	G(M1) Ganglioside	46-61	beta-1,3-galactosyltransferase 4	Homo sapiens	28-35
30611881-2	2019	Based on these observations, the present study examined the extent to which decreased expression of B3GALT4 mRNA and resulting decreased levels of GM1 ganglioside in dopaminergic cells may increase the vulnerability of these cells to degeneration in response to a neurotoxicant exposure that under normal circumstances would not result in neurodegeneration.	G(M1) Ganglioside	147-162	beta-1,3-galactosyltransferase 4	Homo sapiens	100-107
30611881-3	2019	Differentiated SK-N-SH cells were treated with B3GALT4 siRNA to significantly reduce B3GALT4 mRNA expression and decrease GM1 levels.	G(M1) Ganglioside	122-125	beta-1,3-galactosyltransferase 4	Homo sapiens	47-54
30858700-11	2019	Conclusion: Pretreatment with GM1 protects against bupivacaine-induced neurotoxicity via the inhibition of the GRP78/PERK/eIF2alpha/ATF4-mediated ERS.	G(M1) Ganglioside	30-33	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	111-116
30858700-11	2019	Conclusion: Pretreatment with GM1 protects against bupivacaine-induced neurotoxicity via the inhibition of the GRP78/PERK/eIF2alpha/ATF4-mediated ERS.	G(M1) Ganglioside	30-33	eukaryotic translation initiation factor 2A	Rattus norvegicus	122-131
30858700-11	2019	Conclusion: Pretreatment with GM1 protects against bupivacaine-induced neurotoxicity via the inhibition of the GRP78/PERK/eIF2alpha/ATF4-mediated ERS.	G(M1) Ganglioside	30-33	activating transcription factor 4	Rattus norvegicus	132-136
29601870-0	2018	Anti-GM1 ganglioside antibodies modulate membrane-associated sphingomyelin metabolism by altering neutral sphingomyelinase activity.	G(M1) Ganglioside	5-8	sphingomyelin phosphodiesterase 2	Homo sapiens	98-122
30703229-9	2019	CONCLUSION: The c.2006-2007insT and c.475-476 insGGTCC mutations of the GLB1 gene probably underlie the GM1 gangliosidosis resulting in the growth retardation in the child.	G(M1) Ganglioside	104-107	galactosidase beta 1	Homo sapiens	72-76
30729188-5	2019	EPDR1 can interact with membranes that contain negatively charged lipids, including BMP and GM1, and we suggest that EPDR1 may function as a lysosomal activator protein or a lipid transporter.	G(M1) Ganglioside	92-95	ependymin related 1	Homo sapiens	0-5
30555092-0	2018	Identification of a novel GLB1 mutation in a consanguineous Pakistani family affected by rare infantile GM1 gangliosidosis.	G(M1) Ganglioside	104-107	galactosidase beta 1	Homo sapiens	26-30
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	0-32	galactosidase beta 1	Homo sapiens	124-132
30267299-1	2018	GM1 gangliosidosis is an autosomal recessive lysosomal storage disease caused by the deficiency of beta-galactosidase activity, precisely due to mutations in the GLB1 gene.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	162-166
30267299-2	2018	To explore the clinical and molecular characteristics of GM1 gangliosidosis patients from China, GLB1 gene were analyzed in 11 probands with GM1 gangliosidosis by exploiting direct Sanger-sequencing.	G(M1) Ganglioside	57-60	galactosidase beta 1	Homo sapiens	97-101
30267299-2	2018	To explore the clinical and molecular characteristics of GM1 gangliosidosis patients from China, GLB1 gene were analyzed in 11 probands with GM1 gangliosidosis by exploiting direct Sanger-sequencing.	G(M1) Ganglioside	141-144	galactosidase beta 1	Homo sapiens	97-101
30581635-1	2018	GM1 gangliosidosis is an autosomal recessive lysosomal storage disorder due to mutations in the lysosomal acid 3-galactosidase gene, GLB1.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	133-137
30187681-1	2018	BACKGROUND: Beta-galactosidase-1 (GLB1) is a lysosomal hydrolase that is responsible for breaking down specific glycoconjugates, particularly GM1 (monosialotetrahexosylganglioside).	G(M1) Ganglioside	142-145	galactosidase beta 1	Homo sapiens	34-38
30187681-1	2018	BACKGROUND: Beta-galactosidase-1 (GLB1) is a lysosomal hydrolase that is responsible for breaking down specific glycoconjugates, particularly GM1 (monosialotetrahexosylganglioside).	G(M1) Ganglioside	147-179	galactosidase beta 1	Homo sapiens	34-38
30187681-4	2018	We present a 22-month-old proband with GM1 gangliosidosis type II (late-infantile form) in whom a novel homozygous in-frame deletion (c.1468_1470delAAC, p.Asn490del) in GLB1 was detected.	G(M1) Ganglioside	39-42	galactosidase beta 1	Homo sapiens	169-173
29626441-2	2018	The increased bilayer rigidity provided by SM (and to a lesser degree, GM1) reduced the interactions between the SM-enriched bilayer and the N-terminus of Abeta42 (and also residues Ser26, Asn27, and Lys28), which facilitated the formation of a beta-sheet in the normally disordered N-terminal region.	G(M1) Ganglioside	71-74	amyloid beta precursor protein	Homo sapiens	243-249
30210549-6	2018	Mechanistically, we found that GM1 supplementation caused a reduction in the phosphorylation of the platelet-derived growth factor receptor-beta (PDGFR-beta), which is a known inhibitor of osteogenic commitment.	G(M1) Ganglioside	31-34	platelet derived growth factor receptor beta	Homo sapiens	100-144
30210549-6	2018	Mechanistically, we found that GM1 supplementation caused a reduction in the phosphorylation of the platelet-derived growth factor receptor-beta (PDGFR-beta), which is a known inhibitor of osteogenic commitment.	G(M1) Ganglioside	31-34	platelet derived growth factor receptor beta	Homo sapiens	146-156
29987186-0	2018	Teaching NeuroImages: Brain MRI and DaT-SPECT imaging in adult GM1 gangliosidosis.	G(M1) Ganglioside	63-66	solute carrier family 6 member 3	Homo sapiens	36-39
29805504-0	2018	Curative effects of GM1 in the treatment of severe ischemic brain injury and its effects on serum TNF-alpha and NDS.	G(M1) Ganglioside	20-23	tumor necrosis factor	Homo sapiens	98-107
29805504-1	2018	The curative effects of monosialotetrahexosyl ganglioside (GM1) in the treatment of severe ischemic brain injury and its effects on tumor necrosis factor-alpha (TNF-alpha) and neuropathy disability score (NDS).	G(M1) Ganglioside	24-57	tumor necrosis factor	Homo sapiens	132-159
29805504-1	2018	The curative effects of monosialotetrahexosyl ganglioside (GM1) in the treatment of severe ischemic brain injury and its effects on tumor necrosis factor-alpha (TNF-alpha) and neuropathy disability score (NDS).	G(M1) Ganglioside	24-57	tumor necrosis factor	Homo sapiens	161-170
29805504-1	2018	The curative effects of monosialotetrahexosyl ganglioside (GM1) in the treatment of severe ischemic brain injury and its effects on tumor necrosis factor-alpha (TNF-alpha) and neuropathy disability score (NDS).	G(M1) Ganglioside	59-62	tumor necrosis factor	Homo sapiens	132-159
29805504-1	2018	The curative effects of monosialotetrahexosyl ganglioside (GM1) in the treatment of severe ischemic brain injury and its effects on tumor necrosis factor-alpha (TNF-alpha) and neuropathy disability score (NDS).	G(M1) Ganglioside	59-62	tumor necrosis factor	Homo sapiens	161-170
29805504-8	2018	At 14 days after GM1 treatment, the serum TNF-alpha content and the NDS in the experimental group were significantly lower than those in the control group (P&lt;0.05).	G(M1) Ganglioside	17-20	tumor necrosis factor	Homo sapiens	42-51
30422668-3	2019	Indeed, the nontoxic beta subunit of cholera toxin (CTB) can cross the intestinal barrier by binding to receptor GM1.	G(M1) Ganglioside	113-116	phosphate cytidylyltransferase 1B, choline	Homo sapiens	52-55
30422668-8	2019	However, conjugation of bovine serum albumin FITC to CTB increased the internalization in the same cells in a GM1-dependent pathway.	G(M1) Ganglioside	110-113	phosphate cytidylyltransferase 1B, choline	Homo sapiens	53-56
30675867-1	2019	GM1 gangliosidosis is an autosomal recessive disorder caused by galactosidase beta1 (GLB1) gene variants which affect the activity of beta-galactosidase (GLB).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	64-83
30675867-1	2019	GM1 gangliosidosis is an autosomal recessive disorder caused by galactosidase beta1 (GLB1) gene variants which affect the activity of beta-galactosidase (GLB).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	85-89
30675867-1	2019	GM1 gangliosidosis is an autosomal recessive disorder caused by galactosidase beta1 (GLB1) gene variants which affect the activity of beta-galactosidase (GLB).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	134-152
30457145-1	2018	Alzheimer"s disease (AD) is characterized by the overproduction of the amyloid-beta peptide (Abeta) which forms fibrils under the influence of raft microdomains containing the ganglioside GM1.	G(M1) Ganglioside	188-191	amyloid beta precursor protein	Homo sapiens	93-98
30457145-3	2018	Other experiments suggest that Abeta binds preferably to the non-raft liquid disordered (Ld) phase rather than to the Lo phase in the presence of GM1.	G(M1) Ganglioside	146-149	amyloid beta precursor protein	Homo sapiens	31-36
30457145-10	2018	The differential effects of Abeta on spinodal decomposition are accordingly interpreted as resulting from distinct effects of the peptide on the Lo-Ld line tension modulated by GM1.	G(M1) Ganglioside	177-180	amyloid beta precursor protein	Homo sapiens	28-33
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	0-32	galactosidase beta 1	Homo sapiens	145-161
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	0-32	galactosidase beta 1	Homo sapiens	163-167
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	34-37	galactosidase beta 1	Homo sapiens	124-132
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	34-37	galactosidase beta 1	Homo sapiens	145-161
30555092-1	2018	Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (beta-Gal) encoded by galactose beta 1 (GLB1).	G(M1) Ganglioside	34-37	galactosidase beta 1	Homo sapiens	163-167
30145256-4	2018	CTB binding was determined by use of immobilized GM1 to microtiter plates and by immunohistochemistry.	G(M1) Ganglioside	49-52	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-3
30145256-10	2018	Both CTB- and MUC2 binding were inhibited when GM1 was added to the incubation medium.	G(M1) Ganglioside	47-50	phosphate cytidylyltransferase 1B, choline	Homo sapiens	5-8
30145256-10	2018	Both CTB- and MUC2 binding were inhibited when GM1 was added to the incubation medium.	G(M1) Ganglioside	47-50	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	14-18
30018137-6	2018	We also found that the fibrils obtained at GM1-rich nanoclusters were generated from turn Abeta40 Our findings indicate that Abeta generally self-assembles into antiparallel beta-structures but can also form protofibrils with parallel beta-sheets by interacting with ganglioside-bound Abeta.	G(M1) Ganglioside	43-46	amyloid beta precursor protein	Homo sapiens	90-95
30018137-6	2018	We also found that the fibrils obtained at GM1-rich nanoclusters were generated from turn Abeta40 Our findings indicate that Abeta generally self-assembles into antiparallel beta-structures but can also form protofibrils with parallel beta-sheets by interacting with ganglioside-bound Abeta.	G(M1) Ganglioside	43-46	amyloid beta precursor protein	Homo sapiens	125-130
29902255-3	2018	The present study examined the extent to which deficits in gene expression of key biosynthetic enzymes involved in synthesis of GM1 and GD1b (B3galt4) and GD1a and GT1b (St3gal2) exist in neuromelanin-containing neurons in the PD substantia nigra (SN).	G(M1) Ganglioside	128-131	beta-1,3-galactosyltransferase 4	Homo sapiens	142-149
29902255-3	2018	The present study examined the extent to which deficits in gene expression of key biosynthetic enzymes involved in synthesis of GM1 and GD1b (B3galt4) and GD1a and GT1b (St3gal2) exist in neuromelanin-containing neurons in the PD substantia nigra (SN).	G(M1) Ganglioside	128-131	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Homo sapiens	170-177
29601870-6	2018	Both nSMase2 activity and the level of nSMase2 protein were significantly decreased by anti-GM1 treatment of PCtrk cells, while acidic SMase activities remained unchanged.	G(M1) Ganglioside	92-95	sphingomyelin phosphodiesterase 3	Homo sapiens	5-12
29601870-6	2018	Both nSMase2 activity and the level of nSMase2 protein were significantly decreased by anti-GM1 treatment of PCtrk cells, while acidic SMase activities remained unchanged.	G(M1) Ganglioside	92-95	sphingomyelin phosphodiesterase 3	Homo sapiens	39-46
29396849-8	2018	Further, we investigated the phenotype severity of known disease-causing mutations of the GLB1 gene, which lead to 2 LSDs (GM1 gangliosidosis and Morquio disease type B).	G(M1) Ganglioside	123-126	galactosidase beta 1	Homo sapiens	90-94
29411974-3	2018	While the monosialoganglioside GM1 is widely accepted to be the sole receptor for CT, intestinal epithelial cell lines also utilize fucosylated glycan epitopes on glycoproteins to facilitate cell surface binding and endocytic uptake of the toxin.	G(M1) Ganglioside	31-34	phosphate cytidylyltransferase 1B, choline	Homo sapiens	82-84
29439846-1	2018	BACKGROUND: GM1 gangliosidosis is a rare lysosomal storage disorder caused by GLB1 mutations.	G(M1) Ganglioside	12-15	galactosidase beta 1	Homo sapiens	78-82
29439846-4	2018	METHODS: We confirmed a diagnosis of GM1 gangliosidosis based on GLB1 mutations and/or the deficiency of beta-galactosidase activity.	G(M1) Ganglioside	37-40	galactosidase beta 1	Homo sapiens	65-69
29611693-2	2018	In this study, a G-FET device paved with a supported lipid bilayer (referred to as SLB/G-FET) was first used to monitor the catalytic hydrolysis of the SLB by phospholipase D. With excellent detection sensitivity, this G-FET was also modified with a ganglioside GM1-enriched SLB (GM1-SLB/G-FET) to detect cholera toxin B.	G(M1) Ganglioside	262-265	intraflagellar transport 172	Homo sapiens	83-86
29611693-2	2018	In this study, a G-FET device paved with a supported lipid bilayer (referred to as SLB/G-FET) was first used to monitor the catalytic hydrolysis of the SLB by phospholipase D. With excellent detection sensitivity, this G-FET was also modified with a ganglioside GM1-enriched SLB (GM1-SLB/G-FET) to detect cholera toxin B.	G(M1) Ganglioside	262-265	intraflagellar transport 172	Homo sapiens	152-155
29611693-2	2018	In this study, a G-FET device paved with a supported lipid bilayer (referred to as SLB/G-FET) was first used to monitor the catalytic hydrolysis of the SLB by phospholipase D. With excellent detection sensitivity, this G-FET was also modified with a ganglioside GM1-enriched SLB (GM1-SLB/G-FET) to detect cholera toxin B.	G(M1) Ganglioside	262-265	intraflagellar transport 172	Homo sapiens	152-155
29611693-2	2018	In this study, a G-FET device paved with a supported lipid bilayer (referred to as SLB/G-FET) was first used to monitor the catalytic hydrolysis of the SLB by phospholipase D. With excellent detection sensitivity, this G-FET was also modified with a ganglioside GM1-enriched SLB (GM1-SLB/G-FET) to detect cholera toxin B.	G(M1) Ganglioside	262-265	intraflagellar transport 172	Homo sapiens	280-293
30460093-0	2018	GM1 Induced the inflammatory response related to the Raf-1/MEK1/2/ERK1/2 pathway in co-culture of pig mesenchymal stem cells with RAW264.7.	G(M1) Ganglioside	0-3	RAF1	Sus scrofa	53-58
30460093-12	2018	Therefore, the ganglioside GM1 appears to play a major role in the inflammatory response in xenotransplantation via the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	G(M1) Ganglioside	27-30	v-raf-leukemia viral oncogene 1	Mus musculus	120-125
30460093-0	2018	GM1 Induced the inflammatory response related to the Raf-1/MEK1/2/ERK1/2 pathway in co-culture of pig mesenchymal stem cells with RAW264.7.	G(M1) Ganglioside	0-3	Downstream of raf1	Drosophila melanogaster	59-65
30460093-12	2018	Therefore, the ganglioside GM1 appears to play a major role in the inflammatory response in xenotransplantation via the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	G(M1) Ganglioside	27-30	mitogen-activated protein kinase kinase 1	Mus musculus	126-132
30460093-12	2018	Therefore, the ganglioside GM1 appears to play a major role in the inflammatory response in xenotransplantation via the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	G(M1) Ganglioside	27-30	mitogen-activated protein kinase 3	Mus musculus	133-139
30460093-0	2018	GM1 Induced the inflammatory response related to the Raf-1/MEK1/2/ERK1/2 pathway in co-culture of pig mesenchymal stem cells with RAW264.7.	G(M1) Ganglioside	0-3	mitogen-activated protein kinase 3	Sus scrofa	66-72
30460093-12	2018	Therefore, the ganglioside GM1 appears to play a major role in the inflammatory response in xenotransplantation via the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	G(M1) Ganglioside	27-30	mitogen-activated protein kinase 8	Mus musculus	144-148
30460093-9	2018	However, pERK1/2 and pJNK1/2 were decreased and MEK1/2 and Raf1 were suppressed in GM1-knockdown pADMSCs co-cultured with RAW264.7 cells.	G(M1) Ganglioside	83-86	mitogen-activated protein kinase kinase 1	Mus musculus	48-54
30460093-9	2018	However, pERK1/2 and pJNK1/2 were decreased and MEK1/2 and Raf1 were suppressed in GM1-knockdown pADMSCs co-cultured with RAW264.7 cells.	G(M1) Ganglioside	83-86	v-raf-leukemia viral oncogene 1	Mus musculus	59-63
30460093-10	2018	Thus, the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways were significantly upregulated in response to increases of GM1 in co-cultured xenogeneic cells.	G(M1) Ganglioside	109-112	Raf oncogene	Drosophila melanogaster	10-15
30460093-10	2018	Thus, the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways were significantly upregulated in response to increases of GM1 in co-cultured xenogeneic cells.	G(M1) Ganglioside	109-112	Downstream of raf1	Drosophila melanogaster	16-22
30460093-10	2018	Thus, the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways were significantly upregulated in response to increases of GM1 in co-cultured xenogeneic cells.	G(M1) Ganglioside	109-112	rolled	Drosophila melanogaster	23-29
30460093-10	2018	Thus, the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways were significantly upregulated in response to increases of GM1 in co-cultured xenogeneic cells.	G(M1) Ganglioside	109-112	mitogen-activated protein kinase 8	Mus musculus	34-38
30460093-11	2018	However, the inflammatory response was suppressed in co-culture of GM1-knockdown pADMSCs with RAW264.7 cells via down-regulation of the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	G(M1) Ganglioside	67-70	v-raf-leukemia viral oncogene 1	Mus musculus	136-141
30460093-11	2018	However, the inflammatory response was suppressed in co-culture of GM1-knockdown pADMSCs with RAW264.7 cells via down-regulation of the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	G(M1) Ganglioside	67-70	mitogen-activated protein kinase kinase 1	Mus musculus	142-148
30460093-11	2018	However, the inflammatory response was suppressed in co-culture of GM1-knockdown pADMSCs with RAW264.7 cells via down-regulation of the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	G(M1) Ganglioside	67-70	mitogen-activated protein kinase 3	Mus musculus	149-155
30460093-11	2018	However, the inflammatory response was suppressed in co-culture of GM1-knockdown pADMSCs with RAW264.7 cells via down-regulation of the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	G(M1) Ganglioside	67-70	mitogen-activated protein kinase 8	Mus musculus	160-164
29399649-7	2018	The addition of either SM or GM1 decreased htt insertion into the lipid monolayers.	G(M1) Ganglioside	29-32	huntingtin	Homo sapiens	43-46
29428576-0	2018	Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the oxidative stress and inflammatory response via the PI3K/AKT-Nrf2 pathway.	G(M1) Ganglioside	12-15	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
29428576-0	2018	Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the oxidative stress and inflammatory response via the PI3K/AKT-Nrf2 pathway.	G(M1) Ganglioside	12-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
29428576-4	2018	In this study, GM1 supplementation dose-dependently attenuated increase in rat brain water content (BWC) induced by hypobaric chamber (7600 m) exposurefor 24 h. Compared with the HH-treated group, rats injected with GM1 exhibited less brain vascular leakage, lower aquaporin-4 and higher occludin expression, but they also showed increase in Na+/K+-ATPase pump activities.	G(M1) Ganglioside	15-18	aquaporin 4	Rattus norvegicus	265-276
29428576-4	2018	In this study, GM1 supplementation dose-dependently attenuated increase in rat brain water content (BWC) induced by hypobaric chamber (7600 m) exposurefor 24 h. Compared with the HH-treated group, rats injected with GM1 exhibited less brain vascular leakage, lower aquaporin-4 and higher occludin expression, but they also showed increase in Na+/K+-ATPase pump activities.	G(M1) Ganglioside	15-18	occludin	Rattus norvegicus	288-296
29428576-7	2018	Simultaneously, GM1 administration also counteracted the enhanced inflammation in HH-exposed rats by muting pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6 levels in serum and brain tissues.	G(M1) Ganglioside	16-19	interleukin 1 beta	Rattus norvegicus	135-143
29428576-7	2018	Simultaneously, GM1 administration also counteracted the enhanced inflammation in HH-exposed rats by muting pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6 levels in serum and brain tissues.	G(M1) Ganglioside	16-19	tumor necrosis factor	Rattus norvegicus	145-154
29428576-7	2018	Simultaneously, GM1 administration also counteracted the enhanced inflammation in HH-exposed rats by muting pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6 levels in serum and brain tissues.	G(M1) Ganglioside	16-19	interleukin 6	Rattus norvegicus	160-164
29428576-8	2018	Subsequently, GM1 potentiated the activation of the PI3K/AKT-Nrf2 pathway.	G(M1) Ganglioside	14-17	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
29428576-8	2018	Subsequently, GM1 potentiated the activation of the PI3K/AKT-Nrf2 pathway.	G(M1) Ganglioside	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	61-65
29428576-10	2018	Overall, GM1 may afford a protective intervention in HACE by suppressing oxidative stress and inflammatory response via activating the PI3K/AKT-Nrf2 pathway, implying a promising agent for the treatment of HACE.	G(M1) Ganglioside	9-12	AKT serine/threonine kinase 1	Rattus norvegicus	140-143
29428576-10	2018	Overall, GM1 may afford a protective intervention in HACE by suppressing oxidative stress and inflammatory response via activating the PI3K/AKT-Nrf2 pathway, implying a promising agent for the treatment of HACE.	G(M1) Ganglioside	9-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	144-148
29491402-8	2018	We will focus on the lipid components of the MAMs, and highlight how failure to digest or process the sialylated GSL, GM1 ganglioside, in lysosomes alters the lipid conformation and functional properties of the MAMs and leads to neuronal cell death and neurodegeneration.	G(M1) Ganglioside	118-133	cathepsin A	Homo sapiens	113-116
29399649-0	2018	Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes.	G(M1) Ganglioside	18-21	huntingtin	Homo sapiens	32-42
29399649-9	2018	Pure TBLE bilayers and TBLE bilayers enriched with GM1 developed regions of roughened, granular morphologies upon exposure to htt-exon1, but plateau-like domains with a smoother appearance formed in bilayers enriched with SM.	G(M1) Ganglioside	51-54	huntingtin	Homo sapiens	126-129
29306438-6	2018	Single-molecule tracking of fluorescent GM1 and GM3 revealed that these molecules are transiently and dynamically recruited to monomers (monomer-associated rafts) and homodimer rafts of the raftophilic GPI-anchored protein CD59 in quiescent cells, with exponential residency times of 12 and 40ms, respectively, in a manner dependent on raft-lipid interactions.	G(M1) Ganglioside	40-43	CD59 molecule (CD59 blood group)	Homo sapiens	223-227
29306438-7	2018	Upon CD59 stimulation, which induces CD59-cluster signaling rafts, the fluorescent GM1 and GM3 analogs were recruited to the signaling rafts, with a lifetime of 48ms.	G(M1) Ganglioside	83-86	CD59 molecule (CD59 blood group)	Homo sapiens	5-9
29306438-7	2018	Upon CD59 stimulation, which induces CD59-cluster signaling rafts, the fluorescent GM1 and GM3 analogs were recruited to the signaling rafts, with a lifetime of 48ms.	G(M1) Ganglioside	83-86	CD59 molecule (CD59 blood group)	Homo sapiens	37-41
29276840-10	2018	The association between serum albumin concentrations and neurological outcomes was independent of initial injury severity, treatment with GM-1, and polytrauma.	G(M1) Ganglioside	138-142	albumin	Homo sapiens	30-37
29464018-0	2018	Ganglioside GM1 contributes to extracellular/intracellular regulation of insulin resistance, impairment of insulin signaling and down-stream eNOS activation, in human aortic endothelial cells after short- or long-term exposure to TNFalpha.	G(M1) Ganglioside	12-15	insulin	Homo sapiens	73-80
29747816-9	2018	The synthesis of GD3 is switched to the synthesis of complex, brain-type gangliosides, namely, GM1, GD1a, GD1b, and GT1b, resulting in terminal differentiation and loss of "stemness" of NSCs.	G(M1) Ganglioside	95-98	GRDX	Homo sapiens	17-20
29747818-9	2018	The GD1a-to-GM1 "editing" is recognized by such lectins, for example, myelin-associated glycoprotein (siglec-4) losing affinity and galectin-1 gaining reactivity, and then translated into postbinding signaling.	G(M1) Ganglioside	12-15	myelin associated glycoprotein	Homo sapiens	70-100
29747818-9	2018	The GD1a-to-GM1 "editing" is recognized by such lectins, for example, myelin-associated glycoprotein (siglec-4) losing affinity and galectin-1 gaining reactivity, and then translated into postbinding signaling.	G(M1) Ganglioside	12-15	galectin 1	Homo sapiens	132-142
29464018-0	2018	Ganglioside GM1 contributes to extracellular/intracellular regulation of insulin resistance, impairment of insulin signaling and down-stream eNOS activation, in human aortic endothelial cells after short- or long-term exposure to TNFalpha.	G(M1) Ganglioside	12-15	tumor necrosis factor	Homo sapiens	230-238
29464018-6	2018	We show that ganglioside GM1 levels on cell membranes change depending on time of exposure to TNFalpha and its concentration and that the GM1 expression is associated with specific extracellular/intracellular regulation of the insulin signaling cascade.	G(M1) Ganglioside	25-28	eiger	Drosophila melanogaster	94-102
29464018-6	2018	We show that ganglioside GM1 levels on cell membranes change depending on time of exposure to TNFalpha and its concentration and that the GM1 expression is associated with specific extracellular/intracellular regulation of the insulin signaling cascade.	G(M1) Ganglioside	25-28	Insulin-like receptor	Drosophila melanogaster	227-234
29464018-6	2018	We show that ganglioside GM1 levels on cell membranes change depending on time of exposure to TNFalpha and its concentration and that the GM1 expression is associated with specific extracellular/intracellular regulation of the insulin signaling cascade.	G(M1) Ganglioside	138-141	Insulin-like receptor	Drosophila melanogaster	227-234
29464018-8	2018	Our data suggest that GM1 is a key player in the induction of vascular insulin resistance after short- or long-term exposure to TNFalpha and is a good extracellular target for prevention and cure of vascular diseases.	G(M1) Ganglioside	22-25	insulin	Homo sapiens	71-78
29464018-8	2018	Our data suggest that GM1 is a key player in the induction of vascular insulin resistance after short- or long-term exposure to TNFalpha and is a good extracellular target for prevention and cure of vascular diseases.	G(M1) Ganglioside	22-25	tumor necrosis factor	Homo sapiens	128-136
28844949-0	2017	Role of membrane GM1 on early neuronal membrane actions of Abeta during onset of Alzheimer"s disease.	G(M1) Ganglioside	17-20	amyloid beta precursor protein	Homo sapiens	59-64
28844949-3	2017	In this study, we examined if the association and subsequent membrane perforation induced by Abeta was dependent on GM1 levels.	G(M1) Ganglioside	116-119	amyloid beta precursor protein	Homo sapiens	93-98
28844949-5	2017	Interestingly, membrane perforation with Abeta occurred with a slower time course when the GM1 content was diminished (time to establish perforated configuration (TEPC) (min): control=7.8+-2 vs. low GM1=12.1+-0.5, p<0.01), suggesting that the presence of GM1 in the membrane can modulate the distribution and the membrane perforation by Abeta.	G(M1) Ganglioside	91-94	amyloid beta precursor protein	Homo sapiens	41-46
28844949-5	2017	Interestingly, membrane perforation with Abeta occurred with a slower time course when the GM1 content was diminished (time to establish perforated configuration (TEPC) (min): control=7.8+-2 vs. low GM1=12.1+-0.5, p<0.01), suggesting that the presence of GM1 in the membrane can modulate the distribution and the membrane perforation by Abeta.	G(M1) Ganglioside	199-202	amyloid beta precursor protein	Homo sapiens	41-46
28844949-5	2017	Interestingly, membrane perforation with Abeta occurred with a slower time course when the GM1 content was diminished (time to establish perforated configuration (TEPC) (min): control=7.8+-2 vs. low GM1=12.1+-0.5, p<0.01), suggesting that the presence of GM1 in the membrane can modulate the distribution and the membrane perforation by Abeta.	G(M1) Ganglioside	199-202	amyloid beta precursor protein	Homo sapiens	41-46
28844949-7	2017	Additionally, using Cholera Toxin Subunit-B (CTB) to block the interaction of Abeta with GM1 attenuated membrane perforation significantly.	G(M1) Ganglioside	89-92	phosphate cytidylyltransferase 1B, choline	Homo sapiens	20-43
28844949-7	2017	Additionally, using Cholera Toxin Subunit-B (CTB) to block the interaction of Abeta with GM1 attenuated membrane perforation significantly.	G(M1) Ganglioside	89-92	phosphate cytidylyltransferase 1B, choline	Homo sapiens	45-48
28844949-7	2017	Additionally, using Cholera Toxin Subunit-B (CTB) to block the interaction of Abeta with GM1 attenuated membrane perforation significantly.	G(M1) Ganglioside	89-92	amyloid beta precursor protein	Homo sapiens	78-83
28844949-8	2017	Furthermore, pretreatment with CTB decreased the membrane association of Abeta (fluorescent-punctas/20mum, Abeta: control=14.8+-2.5 vs. CTB=8+-1.4, p<0.05), suggesting that GM1 also plays a role in both association of Abeta with the membrane and in perforation.	G(M1) Ganglioside	173-176	phosphate cytidylyltransferase 1B, choline	Homo sapiens	31-34
28946063-1	2017	GM1 has generally been considered as the major receptor that binds to cholera toxin subunit B (CTB) due to its low dissociation constant.	G(M1) Ganglioside	0-3	phosphate cytidylyltransferase 1B, choline	Homo sapiens	70-93
28946063-1	2017	GM1 has generally been considered as the major receptor that binds to cholera toxin subunit B (CTB) due to its low dissociation constant.	G(M1) Ganglioside	0-3	phosphate cytidylyltransferase 1B, choline	Homo sapiens	95-98
28894900-0	2017	Interaction Between Luteinizing Hormone-Releasing Hormone and GM1-Doped Cholesterol/Sphingomyelin Vesicles: A Spectroscopic Study.	G(M1) Ganglioside	62-65	gonadotropin releasing hormone 1	Homo sapiens	20-57
29272022-1	2017	OBJECTIVE: To investigate the effects of ganglioside [monostalotetra-hexosylganglioside (GM1)] on the expressions of caspase-3 and nerve growth factor (NGF) in rats with acute spinal cord injury (SCI).	G(M1) Ganglioside	89-92	caspase 3	Rattus norvegicus	117-126
29272022-1	2017	OBJECTIVE: To investigate the effects of ganglioside [monostalotetra-hexosylganglioside (GM1)] on the expressions of caspase-3 and nerve growth factor (NGF) in rats with acute spinal cord injury (SCI).	G(M1) Ganglioside	89-92	nerve growth factor	Rattus norvegicus	131-150
29272022-1	2017	OBJECTIVE: To investigate the effects of ganglioside [monostalotetra-hexosylganglioside (GM1)] on the expressions of caspase-3 and nerve growth factor (NGF) in rats with acute spinal cord injury (SCI).	G(M1) Ganglioside	89-92	nerve growth factor	Rattus norvegicus	152-155
29272022-11	2017	RT-PCR and Western blotting assay severally proved that the mRNA and protein expressions of caspase-3 were raised in SCI group and decreased clearly after the administration of GM1; while the mRNA and protein expressions of NGF was significantly reduced in SCI group and overtly elevated after the administration of GM1.	G(M1) Ganglioside	177-180	caspase 3	Rattus norvegicus	92-101
29272022-11	2017	RT-PCR and Western blotting assay severally proved that the mRNA and protein expressions of caspase-3 were raised in SCI group and decreased clearly after the administration of GM1; while the mRNA and protein expressions of NGF was significantly reduced in SCI group and overtly elevated after the administration of GM1.	G(M1) Ganglioside	177-180	nerve growth factor	Rattus norvegicus	224-227
29272022-11	2017	RT-PCR and Western blotting assay severally proved that the mRNA and protein expressions of caspase-3 were raised in SCI group and decreased clearly after the administration of GM1; while the mRNA and protein expressions of NGF was significantly reduced in SCI group and overtly elevated after the administration of GM1.	G(M1) Ganglioside	316-319	caspase 3	Rattus norvegicus	92-101
29272022-11	2017	RT-PCR and Western blotting assay severally proved that the mRNA and protein expressions of caspase-3 were raised in SCI group and decreased clearly after the administration of GM1; while the mRNA and protein expressions of NGF was significantly reduced in SCI group and overtly elevated after the administration of GM1.	G(M1) Ganglioside	316-319	nerve growth factor	Rattus norvegicus	224-227
29272022-12	2017	ANOVA showed that there were statistically significant differences in expressions of caspase-3 and NGF among Sham group, SCI group and GM1 group (p&lt;0.05).	G(M1) Ganglioside	135-138	caspase 3	Rattus norvegicus	85-94
29272022-12	2017	ANOVA showed that there were statistically significant differences in expressions of caspase-3 and NGF among Sham group, SCI group and GM1 group (p&lt;0.05).	G(M1) Ganglioside	135-138	nerve growth factor	Rattus norvegicus	99-102
29272022-13	2017	CONCLUSIONS: GM1 has an evident effect on the expressions of caspase-3 and NGF in rats with acute SCI, and is able to down-regulate the expression of caspase-3 and up-regulate the expression of NGF, so as to achieve its therapeutic effect on SCI.	G(M1) Ganglioside	13-16	caspase 3	Rattus norvegicus	61-70
29272022-13	2017	CONCLUSIONS: GM1 has an evident effect on the expressions of caspase-3 and NGF in rats with acute SCI, and is able to down-regulate the expression of caspase-3 and up-regulate the expression of NGF, so as to achieve its therapeutic effect on SCI.	G(M1) Ganglioside	13-16	nerve growth factor	Rattus norvegicus	75-78
29272022-13	2017	CONCLUSIONS: GM1 has an evident effect on the expressions of caspase-3 and NGF in rats with acute SCI, and is able to down-regulate the expression of caspase-3 and up-regulate the expression of NGF, so as to achieve its therapeutic effect on SCI.	G(M1) Ganglioside	13-16	caspase 3	Rattus norvegicus	150-159
29272022-13	2017	CONCLUSIONS: GM1 has an evident effect on the expressions of caspase-3 and NGF in rats with acute SCI, and is able to down-regulate the expression of caspase-3 and up-regulate the expression of NGF, so as to achieve its therapeutic effect on SCI.	G(M1) Ganglioside	13-16	nerve growth factor	Rattus norvegicus	194-197
28894900-9	2017	Using CD, UV-Absorbance, and fluorescence spectroscopy, the effect of Ganglioside Monosialo 1(GM1)-induced conformational changes of LHRH in the presence of Cholesterol (CHOL)/Sphingomyelin (SM) and GM1/CHOL/SM vesicles was studied.	G(M1) Ganglioside	94-97	gonadotropin releasing hormone 1	Homo sapiens	133-137
28894900-10	2017	The aforesaid spectroscopic studies show that LHRH is able to bind with both the vesicles, but GM1-containing vesicles interact more effectively than vesicles without GM1.	G(M1) Ganglioside	167-170	gonadotropin releasing hormone 1	Homo sapiens	46-50
28894900-12	2017	Moreover, binding of LHRH to GM1/CHOL/SM vesicles induces loss of conformational rigidity and attainment of a random coil.	G(M1) Ganglioside	29-32	gonadotropin releasing hormone 1	Homo sapiens	21-25
28673733-6	2017	rCTB in periplasm was purified using an immobilized d-galactose resin; GM1-ELISA experiments showed that rCTB retains strong GM1 ganglioside-binding activity.	G(M1) Ganglioside	71-74	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	105-109
29119347-2	2017	Functional recombinant human alpha-L-iduronidase (IDUA; EC 3.2.1.76) enzymes were generated in seeds of the Arabidopsis thaliana complex-glycan-deficient (cgl) C5 background, which is deficient in the activity of N-acetylglucosaminyl transferase I, and in seeds of the Arabidopsis gm1 mutant, which lacks Golgi alpha-mannosidase I (GM1) activity.	G(M1) Ganglioside	281-284	alpha-L-iduronidase	Homo sapiens	29-48
29119347-2	2017	Functional recombinant human alpha-L-iduronidase (IDUA; EC 3.2.1.76) enzymes were generated in seeds of the Arabidopsis thaliana complex-glycan-deficient (cgl) C5 background, which is deficient in the activity of N-acetylglucosaminyl transferase I, and in seeds of the Arabidopsis gm1 mutant, which lacks Golgi alpha-mannosidase I (GM1) activity.	G(M1) Ganglioside	281-284	alpha-L-iduronidase	Homo sapiens	50-54
29119347-2	2017	Functional recombinant human alpha-L-iduronidase (IDUA; EC 3.2.1.76) enzymes were generated in seeds of the Arabidopsis thaliana complex-glycan-deficient (cgl) C5 background, which is deficient in the activity of N-acetylglucosaminyl transferase I, and in seeds of the Arabidopsis gm1 mutant, which lacks Golgi alpha-mannosidase I (GM1) activity.	G(M1) Ganglioside	332-335	alpha-L-iduronidase	Homo sapiens	29-48
29119347-2	2017	Functional recombinant human alpha-L-iduronidase (IDUA; EC 3.2.1.76) enzymes were generated in seeds of the Arabidopsis thaliana complex-glycan-deficient (cgl) C5 background, which is deficient in the activity of N-acetylglucosaminyl transferase I, and in seeds of the Arabidopsis gm1 mutant, which lacks Golgi alpha-mannosidase I (GM1) activity.	G(M1) Ganglioside	332-335	alpha-L-iduronidase	Homo sapiens	50-54
29119347-3	2017	Both strategies effectively prevented N-glycan maturation and the resultant N-glycan structures on the consensus sites for N-glycosylation of the human enzyme revealed high-mannose N-glycans of predominantly Man5 (cgl-IDUA) or Man6-8 (gm1-IDUA) structures.	G(M1) Ganglioside	235-238	alpha-L-iduronidase	Homo sapiens	218-222
29119347-6	2017	Gm1-IDUA exhibited a slight advantage over the cgl-IDUA in the in vitro M6P-tagging process, with respect to having a better affinity (i.e. lower K m) for the soluble phosphotransferase.	G(M1) Ganglioside	0-3	alpha-L-iduronidase	Homo sapiens	4-8
29111890-5	2017	PEGPLA polymersomes facilitate delivery of active beta-galactosidase to an in vitro model of GM1 gangliosidosis.	G(M1) Ganglioside	93-96	galactosidase beta 1	Homo sapiens	50-68
29119347-8	2017	Our elite cgl- line produces IDUA at &gt; 5.7% TSP (total soluble protein); screening of the gm1 lines showed a maximum yield of 1.5% TSP.	G(M1) Ganglioside	93-96	aldo-keto reductase family 1 member E2	Homo sapiens	134-137
29163491-2	2017	Here, in a chronic plus single-binge ethanol consumption mouse model, we observed that NK cells and interferon-gamma (IFN-gamma) protected against ethanol-induced liver steatosis, as both wild-type (WT) mice treated with anti-asialo GM1 antibody and IFN-gamma-deficient GKO mice developed more severe alcoholic fatty livers.	G(M1) Ganglioside	233-236	interferon gamma	Mus musculus	118-127
28673733-6	2017	rCTB in periplasm was purified using an immobilized d-galactose resin; GM1-ELISA experiments showed that rCTB retains strong GM1 ganglioside-binding activity.	G(M1) Ganglioside	125-140	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	0-4
28673733-6	2017	rCTB in periplasm was purified using an immobilized d-galactose resin; GM1-ELISA experiments showed that rCTB retains strong GM1 ganglioside-binding activity.	G(M1) Ganglioside	125-140	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	105-109
28499815-5	2017	The addition of nanomolar concentration of TRAF2 in GUVs also seems to exert a mechanical action, as demonstrated by the formation of intraluminal vesicles, a process in which ganglioside GM1 plays a crucial role.	G(M1) Ganglioside	188-191	TNF receptor associated factor 2	Homo sapiens	43-48
28778444-4	2017	TNFA -238A allele was more frequent among anti-ganglioside (GM1) antibody-positive patients (P=0.0092) and -863AA associated with AMAN subtype of GBS (P=0.0398).	G(M1) Ganglioside	60-63	tumor necrosis factor	Homo sapiens	0-4
28410623-1	2017	In this perspective we summarize current knowledge of the effect of monosialoganglioside GM1 on the membrane-mediated aggregation of the beta-amyloid (Abeta) peptide.	G(M1) Ganglioside	68-92	amyloid beta precursor protein	Homo sapiens	137-157
28392211-12	2017	Furthermore, GM1 treatment modulated protein levels, increasing GRP78 and reducing CHOP/GADD153 expression along with activation of caspase-12 in the ischemic brain hemispheres.	G(M1) Ganglioside	13-16	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	64-69
28716012-0	2017	Case reports of juvenile GM1 gangliosidosisis type II caused by mutation in GLB1 gene.	G(M1) Ganglioside	25-28	galactosidase beta 1	Homo sapiens	76-80
28392211-12	2017	Furthermore, GM1 treatment modulated protein levels, increasing GRP78 and reducing CHOP/GADD153 expression along with activation of caspase-12 in the ischemic brain hemispheres.	G(M1) Ganglioside	13-16	DNA-damage inducible transcript 3	Rattus norvegicus	83-87
28392211-12	2017	Furthermore, GM1 treatment modulated protein levels, increasing GRP78 and reducing CHOP/GADD153 expression along with activation of caspase-12 in the ischemic brain hemispheres.	G(M1) Ganglioside	13-16	DNA-damage inducible transcript 3	Rattus norvegicus	88-95
28392211-12	2017	Furthermore, GM1 treatment modulated protein levels, increasing GRP78 and reducing CHOP/GADD153 expression along with activation of caspase-12 in the ischemic brain hemispheres.	G(M1) Ganglioside	13-16	caspase 12	Rattus norvegicus	132-142
28288345-4	2017	In line with reported data, the (C-5aR) epimer was found a highly potent experimental pharmacological chaperone for GM1-associated human lysosomal beta-galactosidase mutant R201C.	G(M1) Ganglioside	116-119	complement C5a receptor 1	Homo sapiens	33-38
28674340-3	2017	In this study, each or all phenylalanine (Phe) residues at the 4th, 19th, and 20th positions of Abeta-(1-40) were substituted by hydrophobic cyclohexylalanine (Cha), which is sterically similar to Phe, but lacks pi-electrons, to reveal effects of interactions involving pi-electrons on the aggregation of Abeta both in aqueous solution and GM1-containing membranes.	G(M1) Ganglioside	340-343	amyloid beta precursor protein	Homo sapiens	96-101
32104322-4	2017	It was shown that upon mixed modification, when GM1 contents reached 10% or 15% mol, the ABC phenomenon of the PEGylated liposomal EPI significantly reduced.	G(M1) Ganglioside	48-51	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	89-92
32104322-5	2017	We also found that GM1 played an important role in abrogating the ABC phenomenon in both the induction phase and the effectuation phase.	G(M1) Ganglioside	19-22	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	66-69
27815022-6	2017	Inhibition of the ERK pathway blocked the induction of GM1 through the sigma1R by haloperidol.	G(M1) Ganglioside	55-58	rolled	Drosophila melanogaster	18-21
27815022-9	2017	These findings suggested that the effects of haloperidol on the sigma1R induced GM1 accumulation in the autophagosomes of astrocytes through activating the ERK pathway and a decrease in GM1 expression on the cell surface.	G(M1) Ganglioside	80-83	rolled	Drosophila melanogaster	156-159
28243889-3	2017	LTB has two recognized binding sites; the primary binding site is responsible for anchoring the toxin to its main receptor, the GM1-ganglioside, while the secondary binding site recognizes blood group antigens.	G(M1) Ganglioside	128-143	lymphotoxin beta	Homo sapiens	0-3
28082351-5	2017	In agreement with this finding, FTY720 pretreatment of human NPC1 mutant fibroblasts restored transport of the cholera toxin B subunit, which binds ganglioside GM1, to the Golgi apparatus.	G(M1) Ganglioside	160-163	NPC intracellular cholesterol transporter 1	Homo sapiens	61-65
27624766-9	2016	Addition of mono-sialoganglioside, GM1 ganglioside, to the immobilized lipids significantly improved alpha-Syn detection.	G(M1) Ganglioside	35-50	synuclein alpha	Homo sapiens	101-110
27933798-0	2016	High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-beta to Ganglioside GM1 Containing Nanodiscs.	G(M1) Ganglioside	70-85	amyloid beta precursor protein	Homo sapiens	54-66
27933798-2	2016	Abeta undergoes structural changes upon binding to ganglioside GM1 containing membranes leading to altered molecular characteristics of the protein.	G(M1) Ganglioside	51-66	amyloid beta precursor protein	Homo sapiens	0-5
27933798-3	2016	The physiological role of the Abeta interaction with the ganglioside GM1 is still unclear.	G(M1) Ganglioside	69-72	amyloid beta precursor protein	Homo sapiens	30-35
27933798-6	2016	In particular, we set out to investigate whether the binding activity of GM1 to Abeta is specific for the assembly state of Abeta and compared the binding affinities of monomeric with oligomeric Abeta.	G(M1) Ganglioside	73-76	amyloid beta precursor protein	Homo sapiens	80-85
27933798-6	2016	In particular, we set out to investigate whether the binding activity of GM1 to Abeta is specific for the assembly state of Abeta and compared the binding affinities of monomeric with oligomeric Abeta.	G(M1) Ganglioside	73-76	amyloid beta precursor protein	Homo sapiens	124-129
27933798-6	2016	In particular, we set out to investigate whether the binding activity of GM1 to Abeta is specific for the assembly state of Abeta and compared the binding affinities of monomeric with oligomeric Abeta.	G(M1) Ganglioside	73-76	amyloid beta precursor protein	Homo sapiens	124-129
27806280-3	2016	To gain molecular insight into the organization and dynamics of GSL-rich membranes, we performed all-atom molecular-dynamics simulations of bicomponent ganglioside GM1 in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) phospholipid bilayers with varying concentrations of GM1 (10%, 20%, and 30%).	G(M1) Ganglioside	164-167	cathepsin A	Homo sapiens	64-67
27687691-4	2016	We showed that forced expression of GD2, GM2 or GM1 (by introducing B4GALNT1 cDNA into cells not expressing this glycosyltransferase) results in increases of alpha- and beta-site cleavages of APP with a prominent increase in beta-cleavage.	G(M1) Ganglioside	48-51	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	68-76
27435429-5	2016	Compared to VP8-1-CTB, CTB-VP8-1 showed higher binding activity to both, GM1 and the conformation sensitive neutralizing monoclonal antibodies specific to VP8.	G(M1) Ganglioside	73-76	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	23-26
27515228-4	2016	The regulation of GM1 microdomain density is suggested to involve the oolemmal protein annexin 2 and the magnitude of the inner mitochondrial membrane potential (DeltaPsim) in the adjacent subplasmalemmal cytoplasm.	G(M1) Ganglioside	18-21	annexin A2	Mus musculus	87-96
27486266-10	2016	Interaction of SVS2 and spermatozoa is mediated by the ganglioside GM1 in the sperm membrane; however, both SVS3 and SVS4 had weaker affinities for GM1 than SVS2.	G(M1) Ganglioside	67-70	semenogelin 1	Mus musculus	15-19
27486266-10	2016	Interaction of SVS2 and spermatozoa is mediated by the ganglioside GM1 in the sperm membrane; however, both SVS3 and SVS4 had weaker affinities for GM1 than SVS2.	G(M1) Ganglioside	148-151	semenogelin 1	Mus musculus	15-19
27486266-10	2016	Interaction of SVS2 and spermatozoa is mediated by the ganglioside GM1 in the sperm membrane; however, both SVS3 and SVS4 had weaker affinities for GM1 than SVS2.	G(M1) Ganglioside	148-151	seminal vesicle secretory protein 3A	Mus musculus	108-112
27486266-10	2016	Interaction of SVS2 and spermatozoa is mediated by the ganglioside GM1 in the sperm membrane; however, both SVS3 and SVS4 had weaker affinities for GM1 than SVS2.	G(M1) Ganglioside	148-151	seminal vesicle secretory protein 4	Mus musculus	117-121
27558076-9	2016	GM-1 pretreatment inhibited bupivacaine-induced apoptosis and the expression of caspase-3 and caspase-9 in a dose-dependent manner.	G(M1) Ganglioside	0-4	caspase 3	Mus musculus	80-89
27207911-2	2016	Monosialotetrahexosylganglioside is a crucial ganglioside for the central nervous system and has been reported to affect the function of the brain derived neurotrophic factor system.	G(M1) Ganglioside	0-32	brain derived neurotrophic factor	Mus musculus	141-174
27207911-5	2016	Changes in the brain derived neurotrophic factor signaling pathway after chronic social defeat stress and monosialotetrahexosylganglioside treatment were also investigated.	G(M1) Ganglioside	106-138	brain derived neurotrophic factor	Mus musculus	15-48
27207911-8	2016	In addition, monosialotetrahexosylganglioside completely ameliorated the stress-induced dysfunction of brain derived neurotrophic factor signaling cascade in the hippocampus and medial prefrontal cortex, 2 regions closely involved in the pathophysiology of depression.	G(M1) Ganglioside	13-45	brain derived neurotrophic factor	Mus musculus	103-136
27207911-9	2016	Furthermore, the usage of brain derived neurotrophic factor signaling cascade inhibitors, K252a and anti-brain derived neurotrophic factor antibody, each abolished the antidepressant-like effects of monosialotetrahexosylganglioside, while the usage of a serotonin system inhibitor did not.	G(M1) Ganglioside	199-231	brain derived neurotrophic factor	Mus musculus	26-59
27207911-9	2016	Furthermore, the usage of brain derived neurotrophic factor signaling cascade inhibitors, K252a and anti-brain derived neurotrophic factor antibody, each abolished the antidepressant-like effects of monosialotetrahexosylganglioside, while the usage of a serotonin system inhibitor did not.	G(M1) Ganglioside	199-231	brain derived neurotrophic factor	Mus musculus	105-138
27207911-10	2016	CONCLUSIONS: Taken together, our findings suggest that monosialotetrahexosylganglioside indeed has antidepressant-like effects, and these effects were mediated through the activation of brain derived neurotrophic factor signaling cascade.	G(M1) Ganglioside	55-87	brain derived neurotrophic factor	Mus musculus	186-219
27251370-5	2016	These effects were accompanied by decreased level of T cell surface sialoglycosphingolipid (ganglioside) GM1 that is regulated by the endogenous neuraminidase in response to viral challenge.	G(M1) Ganglioside	105-108	neuraminidase 1	Homo sapiens	145-158
27525911-5	2016	Cell counts and MTT assays demonstrated that in epidermal growth factor (EGF)- and basic fibroblast growth factor (bFGF)-containing medium, a high concentration of GM1, but not NGF, significantly elevated NSC proliferation.	G(M1) Ganglioside	164-167	fibroblast growth factor 2	Homo sapiens	115-119
26960162-3	2016	Monosialotetrahexosylganglioside (GM1) is a ganglioside with wide-ranging pharmacologic effects that enhances the BDNF signaling cascade.	G(M1) Ganglioside	0-32	brain derived neurotrophic factor	Mus musculus	114-118
26960162-3	2016	Monosialotetrahexosylganglioside (GM1) is a ganglioside with wide-ranging pharmacologic effects that enhances the BDNF signaling cascade.	G(M1) Ganglioside	34-37	brain derived neurotrophic factor	Mus musculus	114-118
26960162-7	2016	Consecutive administration of GM1 fully restored the MK801-induced cognitive deficits and the impaired BDNF signaling in the hippocampus.	G(M1) Ganglioside	30-33	brain derived neurotrophic factor	Mus musculus	103-107
26960162-8	2016	Furthermore, a BDNF system inhibitor abolished the effects of GM1 in the MK801 model.	G(M1) Ganglioside	62-65	brain derived neurotrophic factor	Mus musculus	15-19
27295499-3	2016	Membrane components sphingomyelin and GM1 have been shown to promote aggregation of Abeta; however, these studies were performed under extreme, non-physiological conditions.	G(M1) Ganglioside	38-41	amyloid beta precursor protein	Homo sapiens	84-89
27295499-7	2016	The preventive role of GM1 in the oligomerization of Abeta40 suggests that decreasing levels of GM1 in the brain, for example, due to aging, could reduce protection against Abeta oligomerization and contribute to the onset of Alzheimer"s disease.	G(M1) Ganglioside	23-26	amyloid beta precursor protein	Homo sapiens	53-58
27295499-7	2016	The preventive role of GM1 in the oligomerization of Abeta40 suggests that decreasing levels of GM1 in the brain, for example, due to aging, could reduce protection against Abeta oligomerization and contribute to the onset of Alzheimer"s disease.	G(M1) Ganglioside	96-99	amyloid beta precursor protein	Homo sapiens	53-58
27558076-9	2016	GM-1 pretreatment inhibited bupivacaine-induced apoptosis and the expression of caspase-3 and caspase-9 in a dose-dependent manner.	G(M1) Ganglioside	0-4	caspase 9	Mus musculus	94-103
27070150-4	2016	Taking cholera toxin B subunit (CTB) as a model cooperativity system, we studied both GM1 and GM1-like gangliosides binding to CTB.	G(M1) Ganglioside	94-97	phosphate cytidylyltransferase 1B, choline	Homo sapiens	127-130
27357083-9	2016	Accordingly, a fragile X related 1 (FXR1) gene overexpression vector was constructed to investigate the effect of FXR1 overexpression on the level of monosialotetrahexosylganglioside 1 (GM1).	G(M1) Ganglioside	186-189	FMR1 autosomal homolog 1	Homo sapiens	15-34
27357083-9	2016	Accordingly, a fragile X related 1 (FXR1) gene overexpression vector was constructed to investigate the effect of FXR1 overexpression on the level of monosialotetrahexosylganglioside 1 (GM1).	G(M1) Ganglioside	186-189	FMR1 autosomal homolog 1	Homo sapiens	36-40
27357083-9	2016	Accordingly, a fragile X related 1 (FXR1) gene overexpression vector was constructed to investigate the effect of FXR1 overexpression on the level of monosialotetrahexosylganglioside 1 (GM1).	G(M1) Ganglioside	186-189	FMR1 autosomal homolog 1	Homo sapiens	114-118
27357083-10	2016	The results of the current study suggested that FXR1P is a tissue-specific regulator of GM1 levels in SH-SY5Y cells, but not in HEK293T cells.	G(M1) Ganglioside	88-91	FMR1 autosomal homolog 1	Homo sapiens	48-53
27357083-11	2016	Taken together, the results initially indicate that FXR1P interacts with CMAS, and that FXR1P may enhance the activation of sialic acid via interaction with CMAS, and increase GM1 levels to affect the development of the nervous system, thus providing evidence for further research into the pathogenesis of FXS.	G(M1) Ganglioside	176-179	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	73-77
27357083-11	2016	Taken together, the results initially indicate that FXR1P interacts with CMAS, and that FXR1P may enhance the activation of sialic acid via interaction with CMAS, and increase GM1 levels to affect the development of the nervous system, thus providing evidence for further research into the pathogenesis of FXS.	G(M1) Ganglioside	176-179	FMR1 autosomal homolog 1	Homo sapiens	88-93
27410738-8	2016	MHC I and IL-2Ralpha/IL-15Ralpha colocalized with GM1 ganglioside-rich lipid rafts, but MHC I clusters retracted to smaller subsets of GM1- and IL-2Ralpha/IL-15Ralpha-rich areas upon knockdown.	G(M1) Ganglioside	50-53	interleukin 2 receptor subunit alpha	Homo sapiens	10-20
27292265-3	2016	At the onset of mitotic cell rounding, caveolin-1 is targeted to the retracting cortical region at the proximal end of retraction fibres, where ganglioside GM1-enriched membrane domains with clusters of caveola-like structures are formed in an integrin and RhoA-dependent manner.	G(M1) Ganglioside	156-159	caveolin 1	Homo sapiens	39-49
26948382-4	2016	The designed fusion protein designated as TARBP-BTP consists of a double-stranded RNA-binding domain (dsRBD) of human Trans Activation response element (TAR) RNA Binding Protein (TARBP2) fused to a brain targeting peptide that binds to monosialoganglioside GM1.	G(M1) Ganglioside	257-260	TARBP2 subunit of RISC loading complex	Homo sapiens	179-185
27070150-4	2016	Taking cholera toxin B subunit (CTB) as a model cooperativity system, we studied both GM1 and GM1-like gangliosides binding to CTB.	G(M1) Ganglioside	86-89	phosphate cytidylyltransferase 1B, choline	Homo sapiens	127-130
27070150-6	2016	Surprisingly, we demonstrated fucosyl-GM1 has approximately 7 times higher CTB binding capacity than GM1.	G(M1) Ganglioside	38-41	phosphate cytidylyltransferase 1B, choline	Homo sapiens	75-78
26407609-7	2016	Importantly, we find that antibody-mediated cross-linking of Gb3 and GM1, the GSL receptors for Shiga and cholera toxin, respectively, also induces dissociation.	G(M1) Ganglioside	69-72	cathepsin A	Homo sapiens	78-81
26928672-3	2016	Recently, exosome-associated proteins in this MSC EV preparation were found to segregate primarily to those EVs that bind cholera toxin B chain (CTB), a GM1 ganglioside-specific ligand, and pulse-chase experiments demonstrated that these EVs have endosomal origin and carried many of the exosome-associated markers.	G(M1) Ganglioside	153-168	musculin	Homo sapiens	46-49
26997983-7	2016	Conversely, the rats treated with CU or GM1 exhibited attenuated HHBD-induced brain edema and tissue structure disruption, and decreased mRNA and protein expression levels of AQP4.	G(M1) Ganglioside	40-43	aquaporin 4	Rattus norvegicus	175-179
26928672-3	2016	Recently, exosome-associated proteins in this MSC EV preparation were found to segregate primarily to those EVs that bind cholera toxin B chain (CTB), a GM1 ganglioside-specific ligand, and pulse-chase experiments demonstrated that these EVs have endosomal origin and carried many of the exosome-associated markers.	G(M1) Ganglioside	153-168	phosphate cytidylyltransferase 1B, choline	Homo sapiens	122-143
26928672-3	2016	Recently, exosome-associated proteins in this MSC EV preparation were found to segregate primarily to those EVs that bind cholera toxin B chain (CTB), a GM1 ganglioside-specific ligand, and pulse-chase experiments demonstrated that these EVs have endosomal origin and carried many of the exosome-associated markers.	G(M1) Ganglioside	153-168	phosphate cytidylyltransferase 1B, choline	Homo sapiens	145-148
26526326-0	2016	Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca2+ influx.	G(M1) Ganglioside	29-44	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	140-145
26526326-5	2016	Controls with GM1-defective cells (NG-CR72 and neurons from ganglio-series KO mice) were retarded in axonal growth, underscoring the relevance of GM1 as functional counterreceptor for Gal-1.	G(M1) Ganglioside	14-17	lectin, galactose binding, soluble 1	Mus musculus	184-189
26526326-7	2016	Gal-1, as cross-linking lectin, can thus translate metabolic conversion of ganglioside GD1a to GM1 by neuraminidase action into axon growth.	G(M1) Ganglioside	95-98	lectin, galactose binding, soluble 1	Mus musculus	0-5
26526326-8	2016	Galectin-1 (Gal-1) was shown an effector of axonogenesis in cerebellar granule neurons (CGNs) and NG108-15 cells by cross-linking GM1 ganglioside and its associated glycoprotein alpha5 beta1 -integrin.	G(M1) Ganglioside	130-145	lectin, galactose binding, soluble 1	Mus musculus	0-10
26526326-8	2016	Galectin-1 (Gal-1) was shown an effector of axonogenesis in cerebellar granule neurons (CGNs) and NG108-15 cells by cross-linking GM1 ganglioside and its associated glycoprotein alpha5 beta1 -integrin.	G(M1) Ganglioside	130-145	lectin, galactose binding, soluble 1	Mus musculus	12-17
26526326-10	2016	CGNs deficient in GM1 showed retarded axonogenesis, underscoring the relevance of GM1 as functional counterreceptor for Gal-1 in this process.	G(M1) Ganglioside	18-21	lectin, galactose binding, soluble 1	Mus musculus	120-125
26526326-10	2016	CGNs deficient in GM1 showed retarded axonogenesis, underscoring the relevance of GM1 as functional counterreceptor for Gal-1 in this process.	G(M1) Ganglioside	82-85	lectin, galactose binding, soluble 1	Mus musculus	120-125
26526326-11	2016	This Gal-1/GM1-induced signaling was manifest only at the earliest, initiating stage of axon development.	G(M1) Ganglioside	11-14	lectin, galactose binding, soluble 1	Mus musculus	5-10
26711146-4	2016	The clustering of lipid rafts in plasma membranes of MOLT-4 cells was examined with a marker Cholera toxin subunit B conjugates Alexa Fluor (CTB), which binds to the pentasaccharide chains of ganglioside GM1 on the cellular surfaces.	G(M1) Ganglioside	204-207	phosphate cytidylyltransferase 1B, choline	Homo sapiens	141-144
26498762-4	2016	In addition, we reported that epigenetic activation of the GalNAcT gene was also detected as accompanied by an apparent induction of neuronal differentiation in neural stem cells responding to an exogenous supplement of ganglioside GM1.	G(M1) Ganglioside	232-235	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	59-66
26498762-6	2016	We found that nuclear GM1 binds acetylated histones on the promoters of the GalNAcT and NeuroD1 genes in differentiated neurons.	G(M1) Ganglioside	22-25	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	76-83
26498762-6	2016	We found that nuclear GM1 binds acetylated histones on the promoters of the GalNAcT and NeuroD1 genes in differentiated neurons.	G(M1) Ganglioside	22-25	neuronal differentiation 1	Homo sapiens	88-95
26766614-7	2016	Purified proteins representing both fusion orientations were efficiently taken up into GM1 patient fibroblasts and mediated the reduction of GM1 ganglioside substrate with activities matching mammalian cell-derived beta-galactosidase.	G(M1) Ganglioside	141-156	galactosidase beta 1	Homo sapiens	215-233
25495991-7	2016	However, mRNA and protein expressions of IL-1beta significantly decreased in PD+APO+GM1 group compared with PD+APO group (p < 0.05), but mRNA and protein expressions of IL-1beta were also higher in PD+APO+GM1 group than in control group (p < 0.05).	G(M1) Ganglioside	84-87	interleukin 1 alpha	Rattus norvegicus	41-49
26972288-6	2016	It is recognized that Abeta can associate to the plasma membrane and induce the formation of pores after the interaction with lipids like GM1 and cholesterol, and proteins such as APP and NMDA receptors.	G(M1) Ganglioside	138-141	amyloid beta precursor protein	Homo sapiens	22-27
26259785-3	2016	We studied the thermodynamic and structural effects of the presence of GM1 on the interaction between Abeta and liposomes, a good membrane model system.	G(M1) Ganglioside	71-74	amyloid beta precursor protein	Homo sapiens	102-107
26259785-4	2016	Isothermal Titration Calorimetry highlighted the importance of the presence of GM1 in recruiting monomeric Abeta toward the lipid bilayer.	G(M1) Ganglioside	79-82	amyloid beta precursor protein	Homo sapiens	107-112
26259785-5	2016	Light and Small Angle X-ray Scattering revealed a different pattern for GM1 containing liposomes, both before and after interaction with Abeta.	G(M1) Ganglioside	72-75	amyloid beta precursor protein	Homo sapiens	137-142
26259785-6	2016	The results suggest that the interaction with GM1 brings to insertion of Abeta in the bilayer, producing a structural perturbation down to the internal layers of the liposome, as demonstrated by the obtained electron density profiles.	G(M1) Ganglioside	46-49	amyloid beta precursor protein	Homo sapiens	73-78
26405107-5	2016	For this purpose, we used cholera toxin B (CTB) subunit to select CTB-binding peptides that structurally mimic GM1 from a dodecamer phage-display library.	G(M1) Ganglioside	111-114	phosphate cytidylyltransferase 1B, choline	Homo sapiens	43-46
26405107-5	2016	For this purpose, we used cholera toxin B (CTB) subunit to select CTB-binding peptides that structurally mimic GM1 from a dodecamer phage-display library.	G(M1) Ganglioside	111-114	phosphate cytidylyltransferase 1B, choline	Homo sapiens	66-69
26405107-7	2016	Five of the six peptides showed inhibitory activity for GM1 binding to CTB.	G(M1) Ganglioside	56-59	phosphate cytidylyltransferase 1B, choline	Homo sapiens	71-74
26405107-10	2016	Our results thus provide convincing evidence that GM1-replica peptides could serve as novel agents to block CTB binding on epithelial cells and prevent the ensuing physiological effects of CT.	G(M1) Ganglioside	50-53	phosphate cytidylyltransferase 1B, choline	Homo sapiens	108-111
25495991-8	2016	mRNA and protein expressions of IL-1Ra in the striatum were significantly higher in PD+APO+GM1 group than in PD+APO group (p < 0.05).	G(M1) Ganglioside	91-94	interleukin 1 receptor antagonist	Rattus norvegicus	32-38
25495991-9	2016	CONCLUSION: GM1 can inhibit inflammatory reaction through decreasing mRNA and protein expressions of IL-1beta and increasing mRNA and protein expressions of IL-1Ra with the therapeutic effects on PD.	G(M1) Ganglioside	12-15	interleukin 1 alpha	Rattus norvegicus	101-109
25495991-9	2016	CONCLUSION: GM1 can inhibit inflammatory reaction through decreasing mRNA and protein expressions of IL-1beta and increasing mRNA and protein expressions of IL-1Ra with the therapeutic effects on PD.	G(M1) Ganglioside	12-15	interleukin 1 receptor antagonist	Rattus norvegicus	157-163
26293466-7	2015	GM1 (monosialotetrahexosylganglioside)-positive planar lipid rafts, beta3 integrin receptors, and the intracellular signaling transducers focal adhesion kinase and RhoA (Ras homolog gene family, member A) cooperate to promote VEGFR2 long-term polarization and activation.	G(M1) Ganglioside	0-3	kinase insert domain receptor	Homo sapiens	226-232
26640949-10	2015	Detection of monosialoganglioside (GM1) in b-CTB labeled neurons suggests that GM1 ganglioside may specifically enhance the uptake and transneuronal passage of b-CTB, thus supporting the notion that it may be used as a novel transneuronal tracer.	G(M1) Ganglioside	35-38	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	43-48
26640949-10	2015	Detection of monosialoganglioside (GM1) in b-CTB labeled neurons suggests that GM1 ganglioside may specifically enhance the uptake and transneuronal passage of b-CTB, thus supporting the notion that it may be used as a novel transneuronal tracer.	G(M1) Ganglioside	35-38	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	160-165
26640949-10	2015	Detection of monosialoganglioside (GM1) in b-CTB labeled neurons suggests that GM1 ganglioside may specifically enhance the uptake and transneuronal passage of b-CTB, thus supporting the notion that it may be used as a novel transneuronal tracer.	G(M1) Ganglioside	79-94	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	43-48
26640949-10	2015	Detection of monosialoganglioside (GM1) in b-CTB labeled neurons suggests that GM1 ganglioside may specifically enhance the uptake and transneuronal passage of b-CTB, thus supporting the notion that it may be used as a novel transneuronal tracer.	G(M1) Ganglioside	79-94	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	160-165
26362253-8	2015	Similar to dGBA1 knockdown, knockdown of the Drosophila homolog of beta-galactosidase (beta-Gal) also aggravated locomotor dysfunction of the alphaSyn flies, and its substrate GM1 ganglioside accelerated the formation of PK-resistant alphaSyn.	G(M1) Ganglioside	176-191	beta galactosidase	Drosophila melanogaster	67-85
26362253-8	2015	Similar to dGBA1 knockdown, knockdown of the Drosophila homolog of beta-galactosidase (beta-Gal) also aggravated locomotor dysfunction of the alphaSyn flies, and its substrate GM1 ganglioside accelerated the formation of PK-resistant alphaSyn.	G(M1) Ganglioside	176-191	beta galactosidase	Drosophila melanogaster	87-95
26512888-2	2015	The ganglioside (glycolipid) GM1 is thought to be the sole CT receptor; however, the mechanism by which CTB binding to GM1 mediates internalization of CT remains enigmatic.	G(M1) Ganglioside	29-32	phosphate cytidylyltransferase 1B, choline	Homo sapiens	104-107
26512888-2	2015	The ganglioside (glycolipid) GM1 is thought to be the sole CT receptor; however, the mechanism by which CTB binding to GM1 mediates internalization of CT remains enigmatic.	G(M1) Ganglioside	119-122	phosphate cytidylyltransferase 1B, choline	Homo sapiens	104-107
26338710-0	2015	Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells.	G(M1) Ganglioside	12-15	insulin	Homo sapiens	44-51
26338710-9	2015	Taken together, these findings provide the first evidence that GM1 increases in abundance on the cell surface of ECs under the conditions of cellular senescence and aging and causes insulin resistance in ECs.	G(M1) Ganglioside	63-66	Insulin-like receptor	Drosophila melanogaster	182-189
26338710-10	2015	GM1 may be an attractive target for the detection, prevention, and therapy of insulin resistance and related vascular diseases, particularly in older people.	G(M1) Ganglioside	0-3	insulin	Homo sapiens	78-85
26293466-7	2015	GM1 (monosialotetrahexosylganglioside)-positive planar lipid rafts, beta3 integrin receptors, and the intracellular signaling transducers focal adhesion kinase and RhoA (Ras homolog gene family, member A) cooperate to promote VEGFR2 long-term polarization and activation.	G(M1) Ganglioside	5-37	kinase insert domain receptor	Homo sapiens	226-232
26099170-0	2015	GM1 ganglioside in Parkinson"s disease: Pilot study of effects on dopamine transporter binding.	G(M1) Ganglioside	0-15	solute carrier family 6 member 3	Homo sapiens	66-86
26099170-2	2015	The current pilot imaging study was performed to examine effects of GM1 on dopamine transporter binding, as a surrogate measure of disease progression, studied longitudinally.	G(M1) Ganglioside	68-71	solute carrier family 6 member 3	Homo sapiens	75-95
26250646-2	2015	In this work, we conducted coarse-grained simulation to investigate the interactions of binding units of chorela toxin (CTB) with mixed ganglioside GM1 and dipalmitoylphosphatidylcholine (DPPC) lipid bilayer membrane.	G(M1) Ganglioside	148-151	chitobiase	Homo sapiens	120-123
26323692-3	2015	3D electron tomography showed that cortical actin bundled by annexin A2 connected docked secretory granules to the plasma membrane and contributed to the formation of GM1-enriched lipid microdomains at the exocytotic sites in chromaffin cells.	G(M1) Ganglioside	167-170	annexin A2	Homo sapiens	61-71
26459480-0	2015	Role of Protein Kinase Akt Activation in Protective Effect of Ganglioside GM1 on PC12 Cells Exposed to H2O2.	G(M1) Ganglioside	74-77	Akt1	Drosophila melanogaster	23-26
26459480-3	2015	GM1 in concentrations of 100 nM and 10 muM significantly and substantially increased basal activity of protein kinase B (Akt) (the level of phosphorylated Akt form), but had virtually no effect on its expression in PC12 cells.	G(M1) Ganglioside	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	121-124
26459480-3	2015	GM1 in concentrations of 100 nM and 10 muM significantly and substantially increased basal activity of protein kinase B (Akt) (the level of phosphorylated Akt form), but had virtually no effect on its expression in PC12 cells.	G(M1) Ganglioside	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	155-158
26459480-4	2015	In the presence of PI3K inhibitor LY294002 preventing protein kinase Akt activation, the protective effect of GM1 significantly decreased.	G(M1) Ganglioside	110-113	AKT serine/threonine kinase 1	Rattus norvegicus	69-72
26459480-5	2015	These findings suggest that activation of protein kinase Akt by GM1 contributes to improvement of PC12 cell viability by this ganglioside.	G(M1) Ganglioside	64-67	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
26250646-3	2015	We determine that the binding of CTB pentamers cross-links GM1 molecules into protein-sized nanodomains that have distinct lipid order compared with the bulk.	G(M1) Ganglioside	59-62	chitobiase	Homo sapiens	33-36
26250646-6	2015	Comparison simulations on CTB binding to a membrane that is composed of various lipid components demonstrate that several factors are responsible for the nanodomain formation: (a) the negatively charged headgroup of a GM1 receptor is responsible for the multivalent binding; (b) the head groups being full of hydrogen-bonding donors and receptors stabilize the GM1 cluster itself and ensure the toxin binding with high affinity; and	G(M1) Ganglioside	218-221	chitobiase	Homo sapiens	26-29
25964428-1	2015	GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease where GLB1 gene mutations result in a reduction or absence of lysosomal acid beta-galactosidase (betagal) activity.	G(M1) Ganglioside	0-3	galactosidase, beta 1	Mus musculus	83-87
26021803-6	2015	The unexpected finding that GM1 ganglioside inhibited NF-kappaB activation in human monocytes stimulated with CTX and agonists of Toll-like receptors (TLR) suggests the possibility of CTX-TLR interaction.	G(M1) Ganglioside	28-43	toll like receptor 4	Homo sapiens	151-154
26021803-11	2015	CTB targeted not only GM1 and TLR4 but also TREM2 and LMIR5/CD300b.	G(M1) Ganglioside	22-25	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-3
25964428-1	2015	GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease where GLB1 gene mutations result in a reduction or absence of lysosomal acid beta-galactosidase (betagal) activity.	G(M1) Ganglioside	20-23	galactosidase, beta 1	Mus musculus	83-87
25908557-2	2015	Recent reports have shown that the association of Abeta with membranes containing ganglioside GM1 (GM1) plays a pivotal role in amyloid deposition and the pathogenesis of AD.	G(M1) Ganglioside	82-97	amyloid beta precursor protein	Homo sapiens	50-55
25908557-2	2015	Recent reports have shown that the association of Abeta with membranes containing ganglioside GM1 (GM1) plays a pivotal role in amyloid deposition and the pathogenesis of AD.	G(M1) Ganglioside	94-97	amyloid beta precursor protein	Homo sapiens	50-55
26542007-1	2015	The specific interaction of ganglioside GM1 with the homodimeric (prototype) endogenous lectin galectin-1 triggers growth regulation in tumor and activated effector T cells.	G(M1) Ganglioside	40-43	galectin 1	Homo sapiens	95-105
25853032-2	2015	Binding of recombinant LTB and CTB proteins was confirmed based on GM1-ganglioside binding enzyme-linked immunosorbent assays (GM1-ELISA).	G(M1) Ganglioside	67-82	lymphotoxin B	Mus musculus	23-26
25903682-3	2015	GM1-ganglioside-bound Ass (GAss), with unique molecular characteristics such as having an altered conformation and the capability to accelerate Ass assembly, was discovered in an autopsied brain showing early pathological changes of AD in 1995.	G(M1) Ganglioside	0-15	argininosuccinate synthase 1	Homo sapiens	22-25
25903682-3	2015	GM1-ganglioside-bound Ass (GAss), with unique molecular characteristics such as having an altered conformation and the capability to accelerate Ass assembly, was discovered in an autopsied brain showing early pathological changes of AD in 1995.	G(M1) Ganglioside	0-15	argininosuccinate synthase 1	Homo sapiens	28-31
27858734-0	2015	The Diagnostic Utility of Determining Anti-GM1: GalC Complex Antibodies in Multifocal Motor Neuropathy: A Validation Study.	G(M1) Ganglioside	43-46	galactosylceramidase	Homo sapiens	48-52
27858734-3	2015	Existing studies, using a range of different approaches, generally concur that anti-GM1 IgM antibody detection rates are improved by the addition of galactocerebroside (GalC) to the GM1 assay.	G(M1) Ganglioside	84-87	galactosylceramidase	Homo sapiens	169-173
27858734-3	2015	Existing studies, using a range of different approaches, generally concur that anti-GM1 IgM antibody detection rates are improved by the addition of galactocerebroside (GalC) to the GM1 assay.	G(M1) Ganglioside	182-185	galactosylceramidase	Homo sapiens	169-173
27858734-4	2015	OBJECTIVE: The current study sought to formally evaluate the clinical utility of the GM1:GalC complex assay in the diagnosis of MMN.	G(M1) Ganglioside	85-88	galactosylceramidase	Homo sapiens	89-93
27858734-8	2015	Increasing the GalC content to a 1:5 ratio (or higher) further decreased specificity, and in doing so limited the usefulness of the GM1:GalC assay to the level of GM1 alone.	G(M1) Ganglioside	132-135	galactosylceramidase	Homo sapiens	15-19
27858734-8	2015	Increasing the GalC content to a 1:5 ratio (or higher) further decreased specificity, and in doing so limited the usefulness of the GM1:GalC assay to the level of GM1 alone.	G(M1) Ganglioside	163-166	galactosylceramidase	Homo sapiens	15-19
27858734-9	2015	The addition of GalC to the ELISA method also significantly increased sensitivity compared with GM1 alone, albeit with a significant decrease in specificity.	G(M1) Ganglioside	96-99	galactosylceramidase	Homo sapiens	16-20
27858734-10	2015	CONCLUSIONS: This study indicates that the GM1:GalC assay is an advantageous assay adaptation for detecting anti-GM1 antibodies in MMN, using either glycoarray or ELISA, and warrants introduction into clinical diagnostic practice.	G(M1) Ganglioside	43-46	galactosylceramidase	Homo sapiens	47-51
27858734-10	2015	CONCLUSIONS: This study indicates that the GM1:GalC assay is an advantageous assay adaptation for detecting anti-GM1 antibodies in MMN, using either glycoarray or ELISA, and warrants introduction into clinical diagnostic practice.	G(M1) Ganglioside	113-116	galactosylceramidase	Homo sapiens	47-51
25695325-9	2015	Interaction of POMs and sarkosyl with brain homogenates promoted the formation of fibrillar PrP(Sc) aggregates prior to centrifugation, likely through the separation of lipids like GM1 from PrP(Sc).	G(M1) Ganglioside	181-184	prion protein	Mus musculus	92-95
25853032-2	2015	Binding of recombinant LTB and CTB proteins was confirmed based on GM1-ganglioside binding enzyme-linked immunosorbent assays (GM1-ELISA).	G(M1) Ganglioside	67-82	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	31-34
25853032-2	2015	Binding of recombinant LTB and CTB proteins was confirmed based on GM1-ganglioside binding enzyme-linked immunosorbent assays (GM1-ELISA).	G(M1) Ganglioside	67-70	lymphotoxin B	Mus musculus	23-26
25853032-2	2015	Binding of recombinant LTB and CTB proteins was confirmed based on GM1-ganglioside binding enzyme-linked immunosorbent assays (GM1-ELISA).	G(M1) Ganglioside	67-70	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	31-34
25600812-5	2015	GM1 gangliosidosis is caused by mutations in the GLB1 gene that encodes beta-galactosidase.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	49-53
25802972-3	2015	CTB is a 55 kD homopentameric, non-toxic protein binding to the GM1 ganglioside on mammalian cells with high affinity.	G(M1) Ganglioside	64-79	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-3
25765541-5	2015	Injection of anti-asialo-GM1 antibodies to the mice before and after injection of tumour cells attenuated the suppressing effects of CXCL14 on the tumor growth and metastasis, suggesting that NK cell activity played an important role during CXCL14-mediated suppression of tumour growth and metastasis.	G(M1) Ganglioside	25-28	chemokine (C-X-C motif) ligand 14	Mus musculus	133-139
25600812-5	2015	GM1 gangliosidosis is caused by mutations in the GLB1 gene that encodes beta-galactosidase.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	72-90
25600812-6	2015	A lack of beta-galactosidase activity leads to the massive accumulation of GM1 ganglioside, which results in neurodegenerative pathology.	G(M1) Ganglioside	75-90	galactosidase beta 1	Homo sapiens	10-28
25453740-0	2015	Exogenous GM1 ganglioside increases accumbal BDNF levels in rats.	G(M1) Ganglioside	10-25	brain-derived neurotrophic factor	Rattus norvegicus	45-49
25675436-8	2015	Biochemical analyses of brain revealed that the amount of GM1-ganglioside-bound Abeta (GAbeta)--the endogenous seed for Abeta fibril formation in the brain--was clearly elevated in DM-affected monkeys.	G(M1) Ganglioside	58-73	lysosomal alpha-glucosidase	Macaca fascicularis	87-93
25694553-6	2015	The levels of GM1 and GA1 were significantly increased in both the optic nerve and sciatic nerve of the beta-gal -/- mice.	G(M1) Ganglioside	14-17	galactosidase, beta 1	Mus musculus	104-112
25694553-10	2015	The abnormalities in GM1 and myelin lipids in optic nerve of beta-gal -/- mice correlated with a reduction in the relative amount of myelin and periodicity in fresh nerve.	G(M1) Ganglioside	21-24	galactosidase, beta 1	Mus musculus	61-69
25453740-4	2015	This study was performed to investigate the possibility that GM1 may induce changes in BDNF levels in the nucleus accumbens (NAc), a core structure in the brain"s reward circuitry, of rats submitted to three conditioning sessions with cocaine (10 mg/kg, i.p.).	G(M1) Ganglioside	61-64	brain-derived neurotrophic factor	Rattus norvegicus	87-91
25453740-5	2015	The results demonstrate that GM1 administration, which showed no rewarding effect by itself in the CPP, induced a significant increase of BDNF protein levels in the NAc, which may account for the increased rewarding effect of cocaine shown in the CPP paradigm.	G(M1) Ganglioside	29-32	brain-derived neurotrophic factor	Rattus norvegicus	138-142
25545984-8	2015	Furthermore, GM1 ganglioside and its analog MCC-257, which enhance TrkA phosphorylation, overcame the effect of MeHg in neurons, supporting the involvement of the TrkA pathway in MeHg-induced nerve damage.	G(M1) Ganglioside	13-28	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	67-71
25661376-10	2015	Caspase-3, a marker of cellular apoptosis, was shown by immunohistochemistry to be suppressed in protein transcription by GM-1s application and intrathecal GM-1s had potentiated a greater reduction in caspase-3 protein than intravenous GM-1s.	G(M1) Ganglioside	156-161	caspase 3	Rattus norvegicus	201-210
25691190-1	2015	BACKGROUND: GM1 gangliosidosis is a disorder due to GLB1 gene mutation.	G(M1) Ganglioside	12-15	galactosidase beta 1	Homo sapiens	52-56
25661376-10	2015	Caspase-3, a marker of cellular apoptosis, was shown by immunohistochemistry to be suppressed in protein transcription by GM-1s application and intrathecal GM-1s had potentiated a greater reduction in caspase-3 protein than intravenous GM-1s.	G(M1) Ganglioside	122-127	caspase 3	Rattus norvegicus	0-9
25661376-10	2015	Caspase-3, a marker of cellular apoptosis, was shown by immunohistochemistry to be suppressed in protein transcription by GM-1s application and intrathecal GM-1s had potentiated a greater reduction in caspase-3 protein than intravenous GM-1s.	G(M1) Ganglioside	156-161	caspase 3	Rattus norvegicus	201-210
24557856-0	2015	Meningoencephalitis-like onset of post-infectious AQP4-IgG-positive optic neuritis complicated by GM1-IgG-positive acute polyneuropathy.	G(M1) Ganglioside	98-101	aquaporin 4	Homo sapiens	50-54
25545984-8	2015	Furthermore, GM1 ganglioside and its analog MCC-257, which enhance TrkA phosphorylation, overcame the effect of MeHg in neurons, supporting the involvement of the TrkA pathway in MeHg-induced nerve damage.	G(M1) Ganglioside	13-28	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	163-167
26554229-0	2015	Monosialotetrahexosylganglioside Inhibits the Expression of p-CREB and NR2B in the Auditory Cortex in Rats with Salicylate-Induced Tinnitus.	G(M1) Ganglioside	0-32	cAMP responsive element binding protein 1	Rattus norvegicus	62-66
25395676-2	2015	We previously demonstrated that SVS2 regulates fertilization in mice; SVS2 is attached to a ganglioside GM1 on the plasma membrane of the sperm head and inhibits sperm capacitation in in vitro fertilization as a decapacitation factor.	G(M1) Ganglioside	104-107	semenogelin 1	Mus musculus	32-36
25395676-2	2015	We previously demonstrated that SVS2 regulates fertilization in mice; SVS2 is attached to a ganglioside GM1 on the plasma membrane of the sperm head and inhibits sperm capacitation in in vitro fertilization as a decapacitation factor.	G(M1) Ganglioside	104-107	semenogelin 1	Mus musculus	70-74
25454796-0	2015	Neurotropin promotes NGF signaling through interaction of GM1 ganglioside with Trk neurotrophin receptor in PC12 cells.	G(M1) Ganglioside	58-73	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	79-82
25454796-4	2015	Cellular exposure to Neurotropin resulted in an accumulation of Trk-GM1 complexes without affecting dimerization or phosphorylation states of Trk.	G(M1) Ganglioside	68-71	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	64-67
24958345-6	2015	Cholera toxin subunit B (CTB)-specific antibodies immobilized onto superparamagnetic beads and ganglioside GM1-containing liposomes were used for CTB recognition in the detection system.	G(M1) Ganglioside	107-110	phosphate cytidylyltransferase 1B, choline	Homo sapiens	146-149
26554229-0	2015	Monosialotetrahexosylganglioside Inhibits the Expression of p-CREB and NR2B in the Auditory Cortex in Rats with Salicylate-Induced Tinnitus.	G(M1) Ganglioside	0-32	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	71-75
26554229-1	2015	BACKGROUND: This study investigated the effects of monosialotetrahexosylganglioside (GM1) on the expression of N-methyl-D-aspartate receptor subunit 2B (NR2B) and phosphorylated (p)-cyclic AMP response element-binding protein (CREB) in the auditory cortex of rats with tinnitus.	G(M1) Ganglioside	51-83	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	111-151
26554229-1	2015	BACKGROUND: This study investigated the effects of monosialotetrahexosylganglioside (GM1) on the expression of N-methyl-D-aspartate receptor subunit 2B (NR2B) and phosphorylated (p)-cyclic AMP response element-binding protein (CREB) in the auditory cortex of rats with tinnitus.	G(M1) Ganglioside	51-83	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	153-157
26554229-1	2015	BACKGROUND: This study investigated the effects of monosialotetrahexosylganglioside (GM1) on the expression of N-methyl-D-aspartate receptor subunit 2B (NR2B) and phosphorylated (p)-cyclic AMP response element-binding protein (CREB) in the auditory cortex of rats with tinnitus.	G(M1) Ganglioside	85-88	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	111-151
26554229-1	2015	BACKGROUND: This study investigated the effects of monosialotetrahexosylganglioside (GM1) on the expression of N-methyl-D-aspartate receptor subunit 2B (NR2B) and phosphorylated (p)-cyclic AMP response element-binding protein (CREB) in the auditory cortex of rats with tinnitus.	G(M1) Ganglioside	85-88	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	153-157
26554229-1	2015	BACKGROUND: This study investigated the effects of monosialotetrahexosylganglioside (GM1) on the expression of N-methyl-D-aspartate receptor subunit 2B (NR2B) and phosphorylated (p)-cyclic AMP response element-binding protein (CREB) in the auditory cortex of rats with tinnitus.	G(M1) Ganglioside	85-88	cAMP responsive element binding protein 1	Rattus norvegicus	227-231
26554229-5	2015	NR2B mRNA and protein and p-CREB protein levels were upregulated in these animals, with expression returning to normal levels 14 days after cessation of treatment; baseline levels of NR2B and p-CREB were also restored by GM1 administration.	G(M1) Ganglioside	221-224	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	0-4
26554229-5	2015	NR2B mRNA and protein and p-CREB protein levels were upregulated in these animals, with expression returning to normal levels 14 days after cessation of treatment; baseline levels of NR2B and p-CREB were also restored by GM1 administration.	G(M1) Ganglioside	221-224	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	183-187
26554229-5	2015	NR2B mRNA and protein and p-CREB protein levels were upregulated in these animals, with expression returning to normal levels 14 days after cessation of treatment; baseline levels of NR2B and p-CREB were also restored by GM1 administration.	G(M1) Ganglioside	221-224	cAMP responsive element binding protein 1	Rattus norvegicus	194-198
25313007-0	2015	Differential uPAR recruitment in caveolar-lipid rafts by GM1 and GM3 gangliosides regulates endothelial progenitor cells angiogenesis.	G(M1) Ganglioside	57-60	plasminogen activator, urokinase receptor	Homo sapiens	13-17
25313007-10	2015	By confocal microscopy, we have shown that in EPCs uPAR is present on the surface in at least three compartments, respectively, associated to GM1, GM3 and caveolar rafts.	G(M1) Ganglioside	142-145	plasminogen activator, urokinase receptor	Homo sapiens	51-55
25313007-4	2015	On these basis, we first checked the interaction of uPAR with membrane models enriched with GM1 or GM3, relying on the adoption of solid-supported mobile bilayer lipid membranes with raft-like composition formed onto solid hydrophilic surfaces, and evaluated by surface plasmon resonance (SPR) the extent of uPAR recruitment.	G(M1) Ganglioside	92-95	plasminogen activator, urokinase receptor	Homo sapiens	52-56
25313007-5	2015	We estimated the apparent dissociation constants of uPAR-GM1/GM3 complexes.	G(M1) Ganglioside	57-60	plasminogen activator, urokinase receptor	Homo sapiens	52-56
25313007-6	2015	These preliminary observations, indicating that uPAR binds preferentially to GM1-enriched biomimetic membranes, were validated by identifying a pro-angiogenic activity of GM1-enriched EPCs, based on GM1-dependent uPAR recruitment in caveolar rafts.	G(M1) Ganglioside	77-80	plasminogen activator, urokinase receptor	Homo sapiens	48-52
25313007-6	2015	These preliminary observations, indicating that uPAR binds preferentially to GM1-enriched biomimetic membranes, were validated by identifying a pro-angiogenic activity of GM1-enriched EPCs, based on GM1-dependent uPAR recruitment in caveolar rafts.	G(M1) Ganglioside	171-174	plasminogen activator, urokinase receptor	Homo sapiens	48-52
25313007-6	2015	These preliminary observations, indicating that uPAR binds preferentially to GM1-enriched biomimetic membranes, were validated by identifying a pro-angiogenic activity of GM1-enriched EPCs, based on GM1-dependent uPAR recruitment in caveolar rafts.	G(M1) Ganglioside	171-174	plasminogen activator, urokinase receptor	Homo sapiens	213-217
25313007-6	2015	These preliminary observations, indicating that uPAR binds preferentially to GM1-enriched biomimetic membranes, were validated by identifying a pro-angiogenic activity of GM1-enriched EPCs, based on GM1-dependent uPAR recruitment in caveolar rafts.	G(M1) Ganglioside	171-174	plasminogen activator, urokinase receptor	Homo sapiens	48-52
25313007-6	2015	These preliminary observations, indicating that uPAR binds preferentially to GM1-enriched biomimetic membranes, were validated by identifying a pro-angiogenic activity of GM1-enriched EPCs, based on GM1-dependent uPAR recruitment in caveolar rafts.	G(M1) Ganglioside	171-174	plasminogen activator, urokinase receptor	Homo sapiens	213-217
25313007-9	2015	Caveolar-raft isolation and Western blotting of uPAR showed that GM1 promotes caveolar-raft partitioning of uPAR, as opposed to control and GM3-challenged EPCs.	G(M1) Ganglioside	65-68	plasminogen activator, urokinase receptor	Homo sapiens	48-52
25313007-9	2015	Caveolar-raft isolation and Western blotting of uPAR showed that GM1 promotes caveolar-raft partitioning of uPAR, as opposed to control and GM3-challenged EPCs.	G(M1) Ganglioside	65-68	plasminogen activator, urokinase receptor	Homo sapiens	108-112
25216715-0	2014	GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity.	G(M1) Ganglioside	0-15	mitogen activated protein kinase 3	Rattus norvegicus	26-32
25285892-5	2014	GM1 can partially improve the apomorphine induced rotation behavior and changes of glutamate, mitochondria calcium, calmodulin content in striatum of PD rat.	G(M1) Ganglioside	0-3	calmodulin 1	Rattus norvegicus	116-126
25234733-10	2014	Using pure gangliosides as substrates, highest sialidase activity for Neu3a was observed towards GD3 followed by GD1a and GM3, but not GM1.	G(M1) Ganglioside	135-138	sialidase-4-like	Oreochromis niloticus	70-75
25746075-8	2015	This is the first report of PERM, in which GM1 antibodies were detected with GAD and GlyR antibodies.	G(M1) Ganglioside	43-46	glutamate decarboxylase 1	Homo sapiens	77-80
25425333-2	2014	Ganglioside GM1 has been shown to be responsible for the binding of the B subunit of cholera toxin (CT-B), which then helps CT to pass through the membrane, but the exact mechanism remains to be explored.	G(M1) Ganglioside	12-15	phosphate cytidylyltransferase 1B, choline	Homo sapiens	100-104
25039425-0	2014	Leptin inhibits amyloid beta-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway.	G(M1) Ganglioside	67-83	leptin	Homo sapiens	0-6
25039425-0	2014	Leptin inhibits amyloid beta-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway.	G(M1) Ganglioside	67-83	Akt1	Drosophila melanogaster	126-129
25039425-0	2014	Leptin inhibits amyloid beta-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway.	G(M1) Ganglioside	67-83	Megator	Drosophila melanogaster	130-134
25039425-5	2014	Leptin treatment decreased the GM1 ganglioside (GM1) levels in the detergent-resistant membrane microdomains (DRMs) of neurons.	G(M1) Ganglioside	31-46	leptin	Homo sapiens	0-6
25039425-5	2014	Leptin treatment decreased the GM1 ganglioside (GM1) levels in the detergent-resistant membrane microdomains (DRMs) of neurons.	G(M1) Ganglioside	31-34	leptin	Homo sapiens	0-6
25039425-6	2014	The increase in GM1 expression induced by leptin was inhibited after pre-treatment with inhibitors of phosphatidylinositol 3-kinase (LY294002), Akt (triciribine) and the mammalian target of rapamycin (i.e. rapamycin), but not by an inhibitor of extracellular signal-regulated kinase (PD98059).	G(M1) Ganglioside	16-19	leptin	Homo sapiens	42-48
25039425-6	2014	The increase in GM1 expression induced by leptin was inhibited after pre-treatment with inhibitors of phosphatidylinositol 3-kinase (LY294002), Akt (triciribine) and the mammalian target of rapamycin (i.e. rapamycin), but not by an inhibitor of extracellular signal-regulated kinase (PD98059).	G(M1) Ganglioside	16-19	AKT serine/threonine kinase 1	Homo sapiens	144-147
25039425-6	2014	The increase in GM1 expression induced by leptin was inhibited after pre-treatment with inhibitors of phosphatidylinositol 3-kinase (LY294002), Akt (triciribine) and the mammalian target of rapamycin (i.e. rapamycin), but not by an inhibitor of extracellular signal-regulated kinase (PD98059).	G(M1) Ganglioside	16-19	mechanistic target of rapamycin kinase	Homo sapiens	170-199
25039425-7	2014	In addition, pre-treatment with these reagents blocked the induction of GM1 in DRMs by leptin.	G(M1) Ganglioside	72-75	leptin	Homo sapiens	87-93
25039425-10	2014	These results suggest that leptin significantly inhibits Abeta assembly by decreasing GM1 expression in DRMs of the neuronal surface through the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway.	G(M1) Ganglioside	86-89	leptin	Homo sapiens	27-33
25039425-10	2014	These results suggest that leptin significantly inhibits Abeta assembly by decreasing GM1 expression in DRMs of the neuronal surface through the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway.	G(M1) Ganglioside	86-89	amyloid beta precursor protein	Homo sapiens	57-62
25039425-10	2014	These results suggest that leptin significantly inhibits Abeta assembly by decreasing GM1 expression in DRMs of the neuronal surface through the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway.	G(M1) Ganglioside	86-89	AKT serine/threonine kinase 1	Homo sapiens	175-178
25039425-10	2014	These results suggest that leptin significantly inhibits Abeta assembly by decreasing GM1 expression in DRMs of the neuronal surface through the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway.	G(M1) Ganglioside	86-89	mechanistic target of rapamycin kinase	Homo sapiens	179-208
25039425-12	2014	In this study, our aim was to determine whether leptin regulates the expression and localization of GM1 on the neuronal membrane and if it induces the formation of Abeta assembly on the cell surface of neurons.	G(M1) Ganglioside	100-103	leptin	Homo sapiens	48-54
25039425-13	2014	Our results suggest that leptin regulates the expression of GM1 in DRMs of the neuronal membranes.	G(M1) Ganglioside	60-63	leptin	Homo sapiens	25-31
25216715-0	2014	GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity.	G(M1) Ganglioside	0-15	AKT serine/threonine kinase 1	Rattus norvegicus	37-40
25216715-0	2014	GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity.	G(M1) Ganglioside	0-15	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	55-58
25216715-2	2014	These effects of GM1 were abolished by Trk receptor tyrosine kinase inhibitor and diminished by MEK1/2, phosphoinositide 3-kinase and protein kinase C inhibitors.	G(M1) Ganglioside	17-20	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	39-42
25216715-2	2014	These effects of GM1 were abolished by Trk receptor tyrosine kinase inhibitor and diminished by MEK1/2, phosphoinositide 3-kinase and protein kinase C inhibitors.	G(M1) Ganglioside	17-20	mitogen activated protein kinase kinase 1	Rattus norvegicus	96-102
25216715-4	2014	GM1 was found to activate Trk receptor tyrosine kinase in PC12 cells.	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	26-29
25216715-5	2014	GM1 (100 nM and 10 microM) increased the basal activity of Akt, but did not change Akt activity in cells exposed to hydrogen peroxide.	G(M1) Ganglioside	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	59-62
25216715-6	2014	Basal ERK1/2 activity in PC12 cells was increased by GM1 at a concentration of 10 microM, but not at nanomolar concentrations.	G(M1) Ganglioside	53-56	mitogen activated protein kinase 3	Rattus norvegicus	6-12
25216715-7	2014	Activation of ERK1/2 by hydrogen peroxide was enhanced by GM1 at a concentration of 10 microM and to a lesser extent at a concentration of 100 nM.	G(M1) Ganglioside	58-61	mitogen activated protein kinase 3	Rattus norvegicus	14-20
25216715-8	2014	Thus, the protective and metabolic effects of GM1 ganglioside on PC12 cells exposed to hydrogen peroxide appear to depend on the activation of Trk receptor tyrosine kinase and downstream activation of Akt and ERK1/2.	G(M1) Ganglioside	46-61	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	143-146
25216715-8	2014	Thus, the protective and metabolic effects of GM1 ganglioside on PC12 cells exposed to hydrogen peroxide appear to depend on the activation of Trk receptor tyrosine kinase and downstream activation of Akt and ERK1/2.	G(M1) Ganglioside	46-61	AKT serine/threonine kinase 1	Rattus norvegicus	201-204
25216715-8	2014	Thus, the protective and metabolic effects of GM1 ganglioside on PC12 cells exposed to hydrogen peroxide appear to depend on the activation of Trk receptor tyrosine kinase and downstream activation of Akt and ERK1/2.	G(M1) Ganglioside	46-61	mitogen activated protein kinase 3	Rattus norvegicus	209-215
24657793-2	2014	STUDY DESIGN: Cholera toxin B chain (CTB) and annexin V (AV) which respectively binds GM1 ganglioside and phosphatidylserine were used to isolate extracellular vesicles from plasma of PE patients and healthy pregnant women.	G(M1) Ganglioside	86-101	phosphate cytidylyltransferase 1B, choline	Homo sapiens	37-40
24657793-2	2014	STUDY DESIGN: Cholera toxin B chain (CTB) and annexin V (AV) which respectively binds GM1 ganglioside and phosphatidylserine were used to isolate extracellular vesicles from plasma of PE patients and healthy pregnant women.	G(M1) Ganglioside	86-101	annexin A5	Homo sapiens	46-55
24737316-3	2014	In this report, we describe the enzymological properties of purified recombinant human beta-Gal(WT) and two representative mutations in GM1 gangliosidosis Japanese patients, beta-Gal(R201C) and beta-Gal(I51T).	G(M1) Ganglioside	136-139	galactosidase beta 1	Homo sapiens	174-182
25080206-4	2014	Thus, in this study, CTB-LK fusion gene separated by a furin cleavage site was expressed in seeds of Helianthus annuus L. The activity of recombinant protein in seeds of transgenic sunflower was confirmed by Western blot analysis, fibrin plate assays and GM1 -ganglioside ELISA.	G(M1) Ganglioside	255-271	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	21-24
25140899-6	2014	This chimeric peptide retained the property of alpha-synuclein to recognize GM3, and acquired the capacity to recognize GM1 (an Abeta-inherited characteristic).	G(M1) Ganglioside	120-123	amyloid beta precursor protein	Homo sapiens	128-133
25075858-0	2014	N-alpha-acetylation of alpha-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.	G(M1) Ganglioside	81-84	synuclein alpha	Homo sapiens	23-38
23907602-2	2014	Testing for IgM antibodies to other antigens including GM2, the mixture of GM1 and galactocerebroside (GM1/GalC) and the disulfated heparin disaccharide NS6S were reported to increase the sensitivity of antibody testing in MMN even if it is unclear whether the specificity and positive (PPV) or negative predictive value (NPV) for MMN were also affected.	G(M1) Ganglioside	75-78	galactosylceramidase	Homo sapiens	103-111
24737316-1	2014	GM1 gangliosidosis and Morquio B disease are autosomal recessive diseases caused by the defect in the lysosomal beta-galactosidase (beta-Gal), frequently related to misfolding and subsequent endoplasmic reticulum-associated degradation.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	112-130
24737316-1	2014	GM1 gangliosidosis and Morquio B disease are autosomal recessive diseases caused by the defect in the lysosomal beta-galactosidase (beta-Gal), frequently related to misfolding and subsequent endoplasmic reticulum-associated degradation.	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	132-140
24737316-3	2014	In this report, we describe the enzymological properties of purified recombinant human beta-Gal(WT) and two representative mutations in GM1 gangliosidosis Japanese patients, beta-Gal(R201C) and beta-Gal(I51T).	G(M1) Ganglioside	136-139	galactosidase beta 1	Homo sapiens	174-182
24500283-0	2014	Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased beta1-integrin signaling and delayed wound repair.	G(M1) Ganglioside	8-23	CF transmembrane conductance regulator	Homo sapiens	27-31
24884459-2	2014	Previously, we generated a recombinant Lactobacillus casei secreting the cholera toxin B subunit (CTB), which can translocate into intestinal epithelial cells (IECs) through GM1 ganglioside.	G(M1) Ganglioside	174-189	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	98-101
24884459-7	2014	Here, we examined whether rCTB-YVAD secreted by L. casei binds to GM1 ganglioside and inhibits caspase-1 activation in Caco-2 cells used as a model of IECs.	G(M1) Ganglioside	66-81	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	26-30
24884459-10	2014	Both the culture supernatant of pSCTB-YVAD-transformed L. casei and purified rCTB-YVAD bound to GM1 ganglioside, as did the culture supernatant of pSCTB-transformed L. casei and purified rCTB.	G(M1) Ganglioside	96-111	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	77-81
24884459-12	2014	CONCLUSIONS: The rCTB protein fused to a functional peptide secreted by L. casei can bind to GM1 ganglioside, like rCTB, and recombinant YVAD secreted by L. casei may exert anti-inflammatory effects in the intestine.	G(M1) Ganglioside	93-108	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	17-21
24500283-11	2014	Our results suggest that decreased GM1 in CFTR-silenced cells depresses beta1-integrin signaling, which contributes to the delayed wound repair observed in these cells.	G(M1) Ganglioside	35-38	CF transmembrane conductance regulator	Homo sapiens	42-46
24500283-11	2014	Our results suggest that decreased GM1 in CFTR-silenced cells depresses beta1-integrin signaling, which contributes to the delayed wound repair observed in these cells.	G(M1) Ganglioside	35-38	myospheroid	Drosophila melanogaster	72-86
24627559-1	2014	Focus on "Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased beta1-integrin signaling and delayed wound repair".	G(M1) Ganglioside	18-33	CF transmembrane conductance regulator	Homo sapiens	37-41
24627559-1	2014	Focus on "Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased beta1-integrin signaling and delayed wound repair".	G(M1) Ganglioside	18-33	integrin subunit beta 1	Homo sapiens	92-106
24500283-0	2014	Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased beta1-integrin signaling and delayed wound repair.	G(M1) Ganglioside	8-23	integrin subunit beta 1	Homo sapiens	82-96
24500283-8	2014	We found that levels of the glycosphingolipid, GM1 ganglioside, were ~60% lower in CFTR-silenced cells than in controls.	G(M1) Ganglioside	47-62	CF transmembrane conductance regulator	Homo sapiens	83-87
24500283-10	2014	Addition of GM1 (but not GM3) ganglioside to CFTR-silenced cells restored activated beta1-integrin, pFAK, and pCAS to near control levels and partially restored (~40%) cell migration.	G(M1) Ganglioside	12-15	CF transmembrane conductance regulator	Homo sapiens	45-49
24500283-10	2014	Addition of GM1 (but not GM3) ganglioside to CFTR-silenced cells restored activated beta1-integrin, pFAK, and pCAS to near control levels and partially restored (~40%) cell migration.	G(M1) Ganglioside	12-15	myospheroid	Drosophila melanogaster	84-98
24434060-8	2014	Neurons treated with neuraminidase exhibited an increase in GM1 content, a loss in poly-sialoganglioside content, and a decrease in PMCA activity that was greater than that produced by d-PDMP treatment.	G(M1) Ganglioside	60-63	neuraminidase 1	Homo sapiens	21-34
24534465-4	2014	We observed enhanced levels of alpha-synuclein oligomers and gangliosides GM1, GM2, and GM3 and reduced levels of sphingomyelin and autophagy in Batten disease lymphoblast cells compared with normal lymphoblast cells, possibly resulting in a higher rate of apoptosis typically found in Batten disease lymphoblast cells.	G(M1) Ganglioside	74-77	synuclein alpha	Homo sapiens	31-46
24469537-3	2014	METHODS AND RESULTS: Treatment of ApoE(-/-) mice with anti-Asialo-GM1 antibodies depleted NK cells without affecting other lymphocytes, including natural killer T cells, and greatly attenuated atherosclerosis.	G(M1) Ganglioside	66-69	apolipoprotein E	Mus musculus	34-38
24501414-12	2014	Unusually, TFR-41 rotavirus infectivity depended upon terminal Sia and GM1.	G(M1) Ganglioside	71-74	transferrin receptor	Homo sapiens	11-14
24523539-2	2014	We show that activation of Neu3 sialidase, also known as Neuraminidase-3, causing conversion of GD1a and GT1b to GM1 ganglioside, is an essential step in regeneration occurring in PNS (sensory) but not CNS (retinal) axons in adult rat.	G(M1) Ganglioside	113-128	neuraminidase 3	Rattus norvegicus	57-72
24371137-10	2014	Our findings identify a mechanism through which the receptor"s natural ligand and GM1 may protect against toxic intracellular GPR37 aggregates observed in parkinsonism.	G(M1) Ganglioside	82-85	G protein-coupled receptor 37	Mus musculus	126-131
24377861-5	2014	Moreover, PIPLC treatment in noncapacitating conditions caused surface reorganization events that included exposure of the ganglioside GM1, aggregation of flotillin-1, and the swelling of the apical acrosome region; all of which have been reported to be associated with sperm capacitation.	G(M1) Ganglioside	123-138	phospholipase C beta 1	Homo sapiens	10-15
24371137-0	2014	GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability.	G(M1) Ganglioside	77-93	G protein-coupled receptor 37	Mus musculus	0-5
24371137-5	2014	We found that GPR37(tGFP) partitioned in GM1 ganglioside-containing lipid rafts in the plasma membrane of live cells.	G(M1) Ganglioside	41-56	G protein-coupled receptor 37	Mus musculus	14-19
24523539-2	2014	We show that activation of Neu3 sialidase, also known as Neuraminidase-3, causing conversion of GD1a and GT1b to GM1 ganglioside, is an essential step in regeneration occurring in PNS (sensory) but not CNS (retinal) axons in adult rat.	G(M1) Ganglioside	113-128	neuraminidase 3	Rattus norvegicus	27-31
24523539-3	2014	In PNS axons, axotomy activates Neu3 sialidase, increasing the ratio of GM1/GD1a and GM1/GT1b gangliosides immediately after injury in vitro and in vivo.	G(M1) Ganglioside	72-75	neuraminidase 3	Rattus norvegicus	32-36
24523539-3	2014	In PNS axons, axotomy activates Neu3 sialidase, increasing the ratio of GM1/GD1a and GM1/GT1b gangliosides immediately after injury in vitro and in vivo.	G(M1) Ganglioside	85-88	neuraminidase 3	Rattus norvegicus	32-36
23962659-5	2014	The FO diet also suppressed (P&lt; 0 05) the co-localisation of PKCtheta with ganglioside GM1 (monosialotetrahexosylganglioside), a marker for lipid rafts, which is consistent with previous observations.	G(M1) Ganglioside	95-127	protein kinase C, theta	Mus musculus	64-72
24525187-3	2014	Here, we show that sterol efflux and focal enrichment of GM1 trigger Ca(2+) influx necessary for AE through CaV2.3, whose activity has been highly controversial in sperm.	G(M1) Ganglioside	57-60	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	108-114
24525187-6	2014	Using studies in both sperm and voltage clamp of Xenopus oocytes, we define a molecular mechanism for GM1/CaV2.3 regulatory interaction, requiring GM1"s lipid and sugar components and CaV2.3"s alpha1E and alpha2delta subunits.	G(M1) Ganglioside	102-105	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	106-112
24525187-6	2014	Using studies in both sperm and voltage clamp of Xenopus oocytes, we define a molecular mechanism for GM1/CaV2.3 regulatory interaction, requiring GM1"s lipid and sugar components and CaV2.3"s alpha1E and alpha2delta subunits.	G(M1) Ganglioside	102-105	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	184-190
24525187-6	2014	Using studies in both sperm and voltage clamp of Xenopus oocytes, we define a molecular mechanism for GM1/CaV2.3 regulatory interaction, requiring GM1"s lipid and sugar components and CaV2.3"s alpha1E and alpha2delta subunits.	G(M1) Ganglioside	147-150	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	106-112
24184133-12	2014	Induction of Ifng was reduced after administration of an inhibitor of natural killer cell function (anti-asialo GM1).	G(M1) Ganglioside	112-115	interferon gamma	Homo sapiens	13-17
24231767-0	2014	GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis.	G(M1) Ganglioside	0-3	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	54-57
24231767-0	2014	GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis.	G(M1) Ganglioside	0-3	galectin 1	Homo sapiens	93-103
24231767-8	2014	Level of the Gal-1-binding glycolipid GM1 ganglioside also essentially regulated Lck localization.	G(M1) Ganglioside	38-53	galectin 1	Homo sapiens	13-18
24231767-8	2014	Level of the Gal-1-binding glycolipid GM1 ganglioside also essentially regulated Lck localization.	G(M1) Ganglioside	38-53	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
24231767-9	2014	Segregation of Lck and Gal-1 induced apoptosis was diminished in T-cells with low GM1 expression compared to T-cells with high GM1.	G(M1) Ganglioside	82-85	Leucokinin	Drosophila melanogaster	15-18
24231767-9	2014	Segregation of Lck and Gal-1 induced apoptosis was diminished in T-cells with low GM1 expression compared to T-cells with high GM1.	G(M1) Ganglioside	82-85	galectin 1	Homo sapiens	23-28
24231767-9	2014	Segregation of Lck and Gal-1 induced apoptosis was diminished in T-cells with low GM1 expression compared to T-cells with high GM1.	G(M1) Ganglioside	127-130	Leucokinin	Drosophila melanogaster	15-18
24231767-9	2014	Segregation of Lck and Gal-1 induced apoptosis was diminished in T-cells with low GM1 expression compared to T-cells with high GM1.	G(M1) Ganglioside	127-130	galectin 1	Homo sapiens	23-28
24231767-10	2014	Our results show that spatial regulation of Lck by CD45 and GM1 ganglioside determines the outcome of apoptotic response to Gal-1 and this local regulation may occur only upon intimate effector (Gal-1 expressing) cell-T-cell attachment.	G(M1) Ganglioside	60-75	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	44-47
24231767-10	2014	Our results show that spatial regulation of Lck by CD45 and GM1 ganglioside determines the outcome of apoptotic response to Gal-1 and this local regulation may occur only upon intimate effector (Gal-1 expressing) cell-T-cell attachment.	G(M1) Ganglioside	60-75	galectin 1	Homo sapiens	124-129
24482817-0	2014	CD1d favors MHC neighborhood, GM1 ganglioside proximity and low detergent sensitive membrane regions on the surface of B lymphocytes.	G(M1) Ganglioside	30-45	CD1d molecule	Homo sapiens	0-4
24465988-6	2014	Our findings also suggest the GM1-labelled membrane rafts were associated with caveolae and glypican-1/heparan sulfate and varied in concert with these components.	G(M1) Ganglioside	30-33	glypican 1	Homo sapiens	92-102
24482817-10	2014	Physical proximity between CD1d, MHC and GM1 molecules was also detected in the plasma membrane.	G(M1) Ganglioside	41-44	CD1d molecule	Homo sapiens	27-31
24482817-10	2014	Physical proximity between CD1d, MHC and GM1 molecules was also detected in the plasma membrane.	G(M1) Ganglioside	41-44	major histocompatibility complex, class I, C	Homo sapiens	33-36
23831247-1	2013	BACKGROUND: GM1 gangliosidosis is a rare disease due to mutations in the GLB1 gene and autosomal recessive deficiency of beta-galactosidase.	G(M1) Ganglioside	12-15	galactosidase beta 1	Homo sapiens	73-77
24312472-8	2013	Our results indicate that Golgi apparatus and GM1 polarization are controlled by distinct intracellular cascades involving the Ras/Raf/MEK/ERK and the PI3K/Akt/mTOR pathways, respectively.	G(M1) Ganglioside	46-49	Raf oncogene	Drosophila melanogaster	131-134
24312472-8	2013	Our results indicate that Golgi apparatus and GM1 polarization are controlled by distinct intracellular cascades involving the Ras/Raf/MEK/ERK and the PI3K/Akt/mTOR pathways, respectively.	G(M1) Ganglioside	46-49	Downstream of raf1	Drosophila melanogaster	135-138
24312472-8	2013	Our results indicate that Golgi apparatus and GM1 polarization are controlled by distinct intracellular cascades involving the Ras/Raf/MEK/ERK and the PI3K/Akt/mTOR pathways, respectively.	G(M1) Ganglioside	46-49	rolled	Drosophila melanogaster	139-142
24312472-8	2013	Our results indicate that Golgi apparatus and GM1 polarization are controlled by distinct intracellular cascades involving the Ras/Raf/MEK/ERK and the PI3K/Akt/mTOR pathways, respectively.	G(M1) Ganglioside	46-49	Akt1	Drosophila melanogaster	156-159
24312472-8	2013	Our results indicate that Golgi apparatus and GM1 polarization are controlled by distinct intracellular cascades involving the Ras/Raf/MEK/ERK and the PI3K/Akt/mTOR pathways, respectively.	G(M1) Ganglioside	46-49	Megator	Drosophila melanogaster	160-164
24312472-10	2013	The independent biochemical control of GM1 polarity by PI3K and Golgi apparatus polarity by MEK/ERK may act synergistically to regulate and reinforce directional selection in cell migration.	G(M1) Ganglioside	39-42	Downstream of raf1	Drosophila melanogaster	92-95
24312472-10	2013	The independent biochemical control of GM1 polarity by PI3K and Golgi apparatus polarity by MEK/ERK may act synergistically to regulate and reinforce directional selection in cell migration.	G(M1) Ganglioside	39-42	rolled	Drosophila melanogaster	96-99
24013887-9	2013	Our results showed that GM1 treatment prevented Abeta-induced cognitive deficit, corroborating its neuroprotective function.	G(M1) Ganglioside	24-27	amyloid beta precursor protein	Rattus norvegicus	48-53
24013887-11	2013	GM1, in turn, has partially prevented Abeta-induced alteration on Na(+),K(+)-ATPase, though with no impact on AChE activity.	G(M1) Ganglioside	0-3	amyloid beta precursor protein	Rattus norvegicus	38-43
24013887-12	2013	Abeta caused a decrease in antioxidant defense, specifically in hippocampus, an effect that was prevented by GM1 treatment.	G(M1) Ganglioside	109-112	amyloid beta precursor protein	Rattus norvegicus	0-5
23881911-8	2013	Intervention with miglustat in NPC1 patients was accompanied by striking alterations in plasma (reductions in GM1 and GM3 gangliosides) and cerebrospinal fluid (CSF) (increased MCs) sphingolipids.	G(M1) Ganglioside	110-113	NPC intracellular cholesterol transporter 1	Homo sapiens	31-35
24102378-6	2014	Moreover, epigenetic activation of GalNAcT was also detected, as accompanied by a pronounced induction of neural differentiation in primary neuroepithelium culture responding to an exogenous supplement of ganglioside GM1, a downstream product of the gene"s encoding enzyme.	G(M1) Ganglioside	217-220	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	35-42
24046456-7	2013	Moreover, we determined that flotillins are required for cadherin association with GM1-containing plasma membrane microdomains.	G(M1) Ganglioside	83-86	cadherin 1	Homo sapiens	57-65
23814067-8	2013	These data suggest that high expression of the ppGalNAc-T13 gene generates tTn antigen on Syndecan 1 under reduced expression of GM1, leading to enhanced invasion and metastasis via the formation of a molecular complex consisting of integrin alpha5beta1, Syndecan 1, and MMP-9 in the glycolipid-enriched microdomain/rafts.	G(M1) Ganglioside	129-132	syndecan 1	Homo sapiens	90-100
23814067-8	2013	These data suggest that high expression of the ppGalNAc-T13 gene generates tTn antigen on Syndecan 1 under reduced expression of GM1, leading to enhanced invasion and metastasis via the formation of a molecular complex consisting of integrin alpha5beta1, Syndecan 1, and MMP-9 in the glycolipid-enriched microdomain/rafts.	G(M1) Ganglioside	129-132	syndecan 1	Homo sapiens	255-265
23814067-8	2013	These data suggest that high expression of the ppGalNAc-T13 gene generates tTn antigen on Syndecan 1 under reduced expression of GM1, leading to enhanced invasion and metastasis via the formation of a molecular complex consisting of integrin alpha5beta1, Syndecan 1, and MMP-9 in the glycolipid-enriched microdomain/rafts.	G(M1) Ganglioside	129-132	matrix metallopeptidase 9	Homo sapiens	271-276
23499895-5	2013	In addition, depletion of CD8(+) T cells and NK cells using anti-CD8 or anti-asialo GM1 antibody abolished the pulmonary metastasis inhibition mediated by IL-33.	G(M1) Ganglioside	84-87	interleukin 33	Mus musculus	155-160
23688073-3	2013	Molecular dynamics simulations were carried out to investigate the adhesion process of Abeta peptides onto a GM1-ganglioside-containing membrane.	G(M1) Ganglioside	109-124	amyloid beta precursor protein	Homo sapiens	87-92
23688073-7	2013	In the stably bound form, neuraminic acids on the GM1 cluster strongly held the side chain of Lys28 of Abeta, which caused deformation of the C-terminal region of the Abeta.	G(M1) Ganglioside	50-53	amyloid beta precursor protein	Homo sapiens	103-108
23688073-7	2013	In the stably bound form, neuraminic acids on the GM1 cluster strongly held the side chain of Lys28 of Abeta, which caused deformation of the C-terminal region of the Abeta.	G(M1) Ganglioside	50-53	amyloid beta precursor protein	Homo sapiens	167-172
23772214-0	2013	Cholesterol accelerates the binding of Alzheimer"s beta-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation.	G(M1) Ganglioside	75-90	amyloid beta precursor protein	Homo sapiens	51-71
23515399-6	2013	Microscopic observations of the membrane surfaces demonstrated an enhancement in phase separation of lipids as a result of interactions between Abeta and GM1 during induced aggregation of Abeta.	G(M1) Ganglioside	154-157	amyloid beta precursor protein	Homo sapiens	188-193
23515399-7	2013	The uptake of GM1 into Abeta aggregates and the attendant membrane damage were also observed under a microscope when the membrane-anchored aggregates were formed.	G(M1) Ganglioside	14-17	amyloid beta precursor protein	Homo sapiens	23-28
23515399-2	2013	Increasing evidence has indicated that ganglioside GM1 (GM1) in lipid rafts plays a pivotal role in amyloid deposition of Abeta and the related cytotoxicity in AD.	G(M1) Ganglioside	39-54	amyloid beta precursor protein	Homo sapiens	122-127
23515399-2	2013	Increasing evidence has indicated that ganglioside GM1 (GM1) in lipid rafts plays a pivotal role in amyloid deposition of Abeta and the related cytotoxicity in AD.	G(M1) Ganglioside	51-54	amyloid beta precursor protein	Homo sapiens	122-127
23515399-4	2013	In this study, we examined the aggregation of Abeta on supported lipid bilayers containing raft components (i.e., cholesterol, sphingomyelin, and GM1) and its effects on the membrane properties.	G(M1) Ganglioside	146-149	amyloid beta precursor protein	Homo sapiens	46-51
23422796-11	2013	Moreover, propofol and thiopental suppressed GM1-induced fibril formation in a cell-free system (propofol, 75.8 +- 1.9%; thiopental, 83.6 +- 1.9%) and reduced the neurotoxicity of a mixture containing Abeta and GM1 liposomes (propofol, 35.3 +- 16.4%; thiopental, 21.3 +- 11.6%).	G(M1) Ganglioside	45-48	beta amyloid protein precursor-like	Drosophila melanogaster	201-206
28809288-3	2013	It is well established that Ctb (Cholera toxin B subunit) recognizes and binds to GM1 (monosialotetrahexosylganglioside) on the cell surface with high specificity and affinity.	G(M1) Ganglioside	82-85	phosphate cytidylyltransferase 1B, choline	Homo sapiens	28-31
28809288-3	2013	It is well established that Ctb (Cholera toxin B subunit) recognizes and binds to GM1 (monosialotetrahexosylganglioside) on the cell surface with high specificity and affinity.	G(M1) Ganglioside	82-85	phosphate cytidylyltransferase 1B, choline	Homo sapiens	33-56
28809288-3	2013	It is well established that Ctb (Cholera toxin B subunit) recognizes and binds to GM1 (monosialotetrahexosylganglioside) on the cell surface with high specificity and affinity.	G(M1) Ganglioside	87-119	phosphate cytidylyltransferase 1B, choline	Homo sapiens	28-31
28809288-3	2013	It is well established that Ctb (Cholera toxin B subunit) recognizes and binds to GM1 (monosialotetrahexosylganglioside) on the cell surface with high specificity and affinity.	G(M1) Ganglioside	87-119	phosphate cytidylyltransferase 1B, choline	Homo sapiens	33-56
28809288-5	2013	GM1 a natural ligand for cholera toxin, was incorporated into liposome and the interaction between fluorescent Ctb and the liposome was analyzed.	G(M1) Ganglioside	0-3	phosphate cytidylyltransferase 1B, choline	Homo sapiens	111-114
23706082-10	2013	Although the ganglioside GM1 was also used as carbon source, no candidate sialidase genes were found in the genome, instead the substrate degradation is probably due to beta-galactosidase activity.	G(M1) Ganglioside	25-28	beta-galactosidase	Cronobacter sakazakii	169-187
23086918-7	2013	CD1d-KO mice per se showed normal liver regeneration; however, pretreatment with an antiasialo GM1 antibody to CD1d-KO mice, resulting in depletion of both NK and NKT cells, also blunted regenerative responses.	G(M1) Ganglioside	95-98	CD1d1 antigen	Mus musculus	0-4
23508573-6	2013	TLR4 and MD2 are recruited into CD14-containing lipid rafts of RAW264.7 macrophages after stimulation with HMGB1, and TLR4 interacts closely with the lipid raft protein GM1.	G(M1) Ganglioside	169-172	toll like receptor 4	Homo sapiens	0-4
23508573-6	2013	TLR4 and MD2 are recruited into CD14-containing lipid rafts of RAW264.7 macrophages after stimulation with HMGB1, and TLR4 interacts closely with the lipid raft protein GM1.	G(M1) Ganglioside	169-172	lymphocyte antigen 96	Homo sapiens	9-12
23508573-6	2013	TLR4 and MD2 are recruited into CD14-containing lipid rafts of RAW264.7 macrophages after stimulation with HMGB1, and TLR4 interacts closely with the lipid raft protein GM1.	G(M1) Ganglioside	169-172	CD14 molecule	Homo sapiens	32-36
23508573-6	2013	TLR4 and MD2 are recruited into CD14-containing lipid rafts of RAW264.7 macrophages after stimulation with HMGB1, and TLR4 interacts closely with the lipid raft protein GM1.	G(M1) Ganglioside	169-172	high mobility group box 1	Homo sapiens	107-112
23508573-6	2013	TLR4 and MD2 are recruited into CD14-containing lipid rafts of RAW264.7 macrophages after stimulation with HMGB1, and TLR4 interacts closely with the lipid raft protein GM1.	G(M1) Ganglioside	169-172	toll like receptor 4	Homo sapiens	118-122
23523632-2	2013	By means of real-time single particle tracking, we show that amyloid oligomers and aggregates formed by Abeta1-42 and amylin, two peptides associated, respectively, with the development of Alzheimer"s disease and type II diabetes, interact with GM1 and decrease dramatically its lateral diffusion on the plasma membrane of living neuroblastoma cells.	G(M1) Ganglioside	245-248	islet amyloid polypeptide	Homo sapiens	118-124
23294326-5	2013	The Abeta assembly was generated on a distinctive GM1 domain, which was characterized as the Abeta-sensitive ganglioside nanocluster (ASIGN).	G(M1) Ganglioside	50-53	amyloid beta (A4) precursor protein	Mus musculus	4-9
23294326-5	2013	The Abeta assembly was generated on a distinctive GM1 domain, which was characterized as the Abeta-sensitive ganglioside nanocluster (ASIGN).	G(M1) Ganglioside	50-53	amyloid beta (A4) precursor protein	Mus musculus	93-98
23294326-6	2013	By using an artificial GM1 cluster-binding peptide, ASIGN was found to have a high density of GM1; therefore, there would be a critical density of GM1 in nanoclusters to induce Abeta binding and assembly.	G(M1) Ganglioside	23-26	amyloid beta (A4) precursor protein	Mus musculus	177-182
23294326-6	2013	By using an artificial GM1 cluster-binding peptide, ASIGN was found to have a high density of GM1; therefore, there would be a critical density of GM1 in nanoclusters to induce Abeta binding and assembly.	G(M1) Ganglioside	94-97	amyloid beta (A4) precursor protein	Mus musculus	177-182
23294326-6	2013	By using an artificial GM1 cluster-binding peptide, ASIGN was found to have a high density of GM1; therefore, there would be a critical density of GM1 in nanoclusters to induce Abeta binding and assembly.	G(M1) Ganglioside	94-97	amyloid beta (A4) precursor protein	Mus musculus	177-182
22845664-3	2013	Retinoid analogs have been shown to modulate ceramide levels in the cell membrane, while cholera toxin B subunit (CT-B) specifically binds to the ganglioside GM1.	G(M1) Ganglioside	158-161	phosphate cytidylyltransferase 1B, choline	Homo sapiens	89-112
22845664-3	2013	Retinoid analogs have been shown to modulate ceramide levels in the cell membrane, while cholera toxin B subunit (CT-B) specifically binds to the ganglioside GM1.	G(M1) Ganglioside	158-161	phosphate cytidylyltransferase 1B, choline	Homo sapiens	114-118
23086918-7	2013	CD1d-KO mice per se showed normal liver regeneration; however, pretreatment with an antiasialo GM1 antibody to CD1d-KO mice, resulting in depletion of both NK and NKT cells, also blunted regenerative responses.	G(M1) Ganglioside	95-98	CD1d1 antigen	Mus musculus	111-115
23546002-10	2013	A stable hydrophobic interaction between CHL and beta2AR was observed at transmembrane helix5 in POPC/CHL/GM1 and POPC/POPE/CHL/SM membranes.	G(M1) Ganglioside	106-109	adrenoceptor beta 2	Homo sapiens	49-56
23256886-1	2013	A mixed phospholipid-cholestrol bilayer, with cholera toxin B (CTB) units attached to the monosialotetrahexosylganglioside (GM1) binding sites in the distal leaflet, was deposited on a Au(111) electrode surface.	G(M1) Ganglioside	124-127	phosphate cytidylyltransferase 1B, choline	Homo sapiens	63-66
24129486-7	2013	After treated with GM1, the percentage of MBP-positive cells increased significantly than WMD rats at post-operation 72 h and day 7.	G(M1) Ganglioside	19-22	myelin basic protein	Rattus norvegicus	42-45
23622392-2	2013	GM1 and GM2 gangliosidosis are associated with deficiency of beta-galactosidase and beta-hexosaminidase respectively.	G(M1) Ganglioside	0-3	O-GlcNAcase	Homo sapiens	84-103
23046582-3	2013	Here we review GLB1 mutations and clinical features from 65 Brazilian GM1 gangliosidosis patients.	G(M1) Ganglioside	70-73	galactosidase beta 1	Homo sapiens	15-19
24391082-4	2013	Using the microantibody as a library scaffold, we have constructed a phage-display library to successfully isolate molecular-targeting peptides against a cytokine receptor (granulocyte colony-stimulating factor receptor), a protein kinase (Aurora-A), and a ganglioside (GM1).	G(M1) Ganglioside	270-273	colony stimulating factor 3 receptor	Homo sapiens	173-219
24391082-4	2013	Using the microantibody as a library scaffold, we have constructed a phage-display library to successfully isolate molecular-targeting peptides against a cytokine receptor (granulocyte colony-stimulating factor receptor), a protein kinase (Aurora-A), and a ganglioside (GM1).	G(M1) Ganglioside	270-273	aurora kinase A	Homo sapiens	240-248
23326286-6	2012	However, the expression of GM1 significantly decreased in PAECs incubated for 5 h with TNF-alpha (10 ng/mL), 10% human serum containing human leukocytes, and 10% FBS containing human leukocytes.	G(M1) Ganglioside	27-30	tumor necrosis factor	Homo sapiens	87-96
23555818-0	2013	GLTP mediated non-vesicular GM1 transport between native membranes.	G(M1) Ganglioside	28-31	glycolipid transfer protein	Homo sapiens	0-4
23555818-3	2013	Using the soluble LTP glycolipid transfer protein (GLTP), we examined GM1 (monosialotetrahexosyl-ganglioside) transfer to native membrane surfaces.	G(M1) Ganglioside	70-73	glycolipid transfer protein	Homo sapiens	51-55
23555818-4	2013	With artificial GM1 donor liposomes, GLTP can be used to increase glycolipid levels over natural levels in either side of the membrane leaflet, i.e., external or cytosolic.	G(M1) Ganglioside	16-19	glycolipid transfer protein	Homo sapiens	37-41
23555818-5	2013	In a system with native donor- and acceptor-membranes, we find that GLTP balances highly variable GM1 concentrations in a population of membranes from one cell type, and in addition, transfers lipids between membranes from different cell types.	G(M1) Ganglioside	98-101	glycolipid transfer protein	Homo sapiens	68-72
23662477-0	2013	[Metabolic effects of ganglioside GM1 on PC12 cells at oxidative stress depend on modulation of activity of tyrosine kinase of trk receptor].	G(M1) Ganglioside	34-37	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	127-130
23662477-4	2013	It was found that in the presence of K-252a, an inhibitor of tyrosine kinase of Trk receptors, GM1 at concentrations of 10 microM and 10 nM lost the ability to increase viability of these cells under conditions of oxidative stress.	G(M1) Ganglioside	95-98	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	80-83
23662477-5	2013	The dependence of protective and metabolic effects of ganglioside GM 1 in PC 12 cells at action on them of H2O2 on modulation of activity of tyrosine kinase of Trk receptors (i. e., on the same signal system) agrees with concept of the essential role of the GM1 antioxidant effect in its increase of cell viability.	G(M1) Ganglioside	66-70	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	160-163
23662477-5	2013	The dependence of protective and metabolic effects of ganglioside GM 1 in PC 12 cells at action on them of H2O2 on modulation of activity of tyrosine kinase of Trk receptors (i. e., on the same signal system) agrees with concept of the essential role of the GM1 antioxidant effect in its increase of cell viability.	G(M1) Ganglioside	258-261	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	160-163
22733027-4	2012	RESULTS: Cold storage induced deglycosylation of glycoprotein Ibalpha ectodomain, exposing N-acetyl-D-glucosamine residues, which sequestered with GM1 gangliosides in lipid rafts.	G(M1) Ganglioside	147-163	glycoprotein Ib platelet subunit alpha	Homo sapiens	49-69
22745492-4	2012	We document two pools of SERT proteins defined by lateral mobility, one that exhibits relatively free diffusion, and a second, localized to cholesterol and GM1 ganglioside-enriched microdomains, that displays restricted mobility.	G(M1) Ganglioside	156-171	solute carrier family 6 member 4	Homo sapiens	25-29
22502994-4	2012	Experimental results revealed the preferential distribution of CTB (cholera toxin B)-GM1 complexes mainly on the spherical cell membrane, and cholesterol-sphingomyelin at the membrane leading edge and ICNs.	G(M1) Ganglioside	85-88	phosphate cytidylyltransferase 1B, choline	Homo sapiens	63-66
22699929-9	2012	Anti asialo GM1 could reduce natural killer cell cytotoxicity, production of IFN-gamma, and regression of LLC tumor aroused by IL18-IL2.	G(M1) Ganglioside	12-15	interferon gamma	Mus musculus	77-86
22699929-9	2012	Anti asialo GM1 could reduce natural killer cell cytotoxicity, production of IFN-gamma, and regression of LLC tumor aroused by IL18-IL2.	G(M1) Ganglioside	12-15	interleukin 18	Homo sapiens	127-135
22968393-1	2012	The neurotrophic factor-like activity of monosialoganglioside (GM1) has been shown to activate tyrosine kinase receptors (Trk).	G(M1) Ganglioside	63-66	trunk	Drosophila melanogaster	95-120
22968393-1	2012	The neurotrophic factor-like activity of monosialoganglioside (GM1) has been shown to activate tyrosine kinase receptors (Trk).	G(M1) Ganglioside	63-66	trunk	Drosophila melanogaster	122-125
22968393-4	2012	However, much less is known about the effects of GM1 or/and target SKM cells on the expression of Trk receptors in dorsal root ganglion (DRG) neurons.	G(M1) Ganglioside	49-52	trunk	Drosophila melanogaster	98-101
22968393-6	2012	In this experiment, we found that: (1) GM1 promoted expression of TrkA and TrkB but not TrkC in primary cultured DRG neurons; (2) target SKM cells promoted expression of TrkC but not TrkA and TrkB in neuromuscular cocultures without GM1 treatment; and (3) GM1 and target SKM cells had additional effects on expression of these three Trk receptors.	G(M1) Ganglioside	39-42	trunk	Drosophila melanogaster	66-69
22968393-7	2012	The results of the present study offered new clues for a better understanding of the association of GM1 and target SKM on the expression of Trk receptors.	G(M1) Ganglioside	100-103	trunk	Drosophila melanogaster	140-143
22877735-6	2012	The incorporation of Ptx in GM1 reached an optimum at GM1/Ptx 20/1 molar ratio when performed at room temperature.	G(M1) Ganglioside	28-31	paired like homeodomain 1	Homo sapiens	54-66
22824320-3	2012	Here we investigate the change of neurotensin solution structure induced by isotropic CHAPS-PC bicelles with and without ganglioside GM1 using solution state NMR spectroscopy.	G(M1) Ganglioside	133-136	neurotensin	Homo sapiens	34-45
22824320-9	2012	Neurotensin interacts better with GM1 containing bicelle than that of the CHAPS-PC bicelle.	G(M1) Ganglioside	34-37	neurotensin	Homo sapiens	0-11
22824320-10	2012	Docking studies between the Neurotensin Receptor3 (NTS3) and different NT conformations also indicated better binding of the NT conformation obtained in presence of GM1-containing bicelles.	G(M1) Ganglioside	165-168	sortilin 1	Homo sapiens	28-49
22824320-10	2012	Docking studies between the Neurotensin Receptor3 (NTS3) and different NT conformations also indicated better binding of the NT conformation obtained in presence of GM1-containing bicelles.	G(M1) Ganglioside	165-168	sortilin 1	Homo sapiens	51-55
22714832-2	2012	We recently demonstrated that genetically engineered mice (B4galnt1(-/-) ) devoid of GM1 acquire characteristic symptoms of this disorder, including motor impairment, depletion of striatal dopamine, selective loss of tyrosine hydroxylase-expressing neurons, and aggregation of alpha-synuclein.	G(M1) Ganglioside	85-88	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	59-67
22846995-0	2012	Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cells.	G(M1) Ganglioside	56-71	galectin	Drosophila melanogaster	0-8
22846995-4	2012	Here we show that galectin-3 and N-cadherin interact and colocalize with the lipid raft marker GM1 ganglioside in cell-cell junctions of mammary epithelial cancer cells.	G(M1) Ganglioside	95-110	galectin	Drosophila melanogaster	18-26
22846995-4	2012	Here we show that galectin-3 and N-cadherin interact and colocalize with the lipid raft marker GM1 ganglioside in cell-cell junctions of mammary epithelial cancer cells.	G(M1) Ganglioside	95-110	Cadherin-N	Drosophila melanogaster	33-43
22846995-9	2012	Galectin lattice integrity increases the mobile fraction of the raft marker, GM1 ganglioside binding cholera toxin B subunit Ctb, at cell-cell contacts in a p120-catenin-independent manner, but does not affect the mobility of either Ctb-labeled GM1 or GFP-coupled N-cadherin in nonjunctional regions.	G(M1) Ganglioside	77-92	galectin	Drosophila melanogaster	0-8
22846995-9	2012	Galectin lattice integrity increases the mobile fraction of the raft marker, GM1 ganglioside binding cholera toxin B subunit Ctb, at cell-cell contacts in a p120-catenin-independent manner, but does not affect the mobility of either Ctb-labeled GM1 or GFP-coupled N-cadherin in nonjunctional regions.	G(M1) Ganglioside	77-80	galectin	Drosophila melanogaster	0-8
22484968-1	2012	In this mini-review I summarize our research efforts in ascertaining the possible neuro-reparative properties of the GM1 ganglioside and its cooperative effects with NGF in stroke-lesion models.	G(M1) Ganglioside	117-132	nerve growth factor	Homo sapiens	166-169
22385841-4	2012	Some residues in the Abeta sequence seem to promote Abeta-induced toxicity in association with age-dependent risk factors for AD, such as (i) increased GM1 brain membrane content, (ii) altered lipid domain in brain membrane, (iii) oxidative stress.	G(M1) Ganglioside	152-155	amyloid beta precursor protein	Homo sapiens	21-26
22385841-4	2012	Some residues in the Abeta sequence seem to promote Abeta-induced toxicity in association with age-dependent risk factors for AD, such as (i) increased GM1 brain membrane content, (ii) altered lipid domain in brain membrane, (iii) oxidative stress.	G(M1) Ganglioside	152-155	amyloid beta precursor protein	Homo sapiens	52-57
22385841-6	2012	As Tyr10 is implicated in the induction of oxidative stress and stabilization of Abeta aggregation, we substituted Tyr 10 with a synthetic amino acid that abolishes Abeta-induced oxidative stress and shows an accelerated interaction with GM1.	G(M1) Ganglioside	238-241	amyloid beta precursor protein	Homo sapiens	81-86
22385841-10	2012	It demonstrates the relevance of Abeta sequence in (i) Abeta-membrane interaction, underlining the role of age-dependent enhanced GM1 content in promoting Abeta aggregation, (ii) Abeta aggregation, and (iii) Abeta-induced oxidative stress.	G(M1) Ganglioside	130-133	amyloid beta precursor protein	Homo sapiens	33-38
22385841-10	2012	It demonstrates the relevance of Abeta sequence in (i) Abeta-membrane interaction, underlining the role of age-dependent enhanced GM1 content in promoting Abeta aggregation, (ii) Abeta aggregation, and (iii) Abeta-induced oxidative stress.	G(M1) Ganglioside	130-133	amyloid beta precursor protein	Homo sapiens	55-60
22385841-10	2012	It demonstrates the relevance of Abeta sequence in (i) Abeta-membrane interaction, underlining the role of age-dependent enhanced GM1 content in promoting Abeta aggregation, (ii) Abeta aggregation, and (iii) Abeta-induced oxidative stress.	G(M1) Ganglioside	130-133	amyloid beta precursor protein	Homo sapiens	55-60
22634013-5	2012	Similarly, osmium tetroxide completely prohibited CTB plus anti-CTB-induced GM1 patching in representatives for flat membrane, i.e. discoid erythrocytes and K562 cells.	G(M1) Ganglioside	76-79	phosphate cytidylyltransferase 1B, choline	Homo sapiens	64-67
22234367-0	2012	Four novel mutations in the beta-galactosidase gene identified in infantile type of GM1 gangliosidosis.	G(M1) Ganglioside	84-87	galactosidase beta 1	Homo sapiens	28-46
22289946-0	2012	Intravenous immunoglobulin treatment on anti-GM1 antibodies associated neuropathies inhibits cholera toxin and galectin-1 binding to ganglioside GM1.	G(M1) Ganglioside	45-48	galectin 1	Homo sapiens	111-121
22033734-5	2012	Our previous work on mutations of the beta-galactosidase (beta-gal) gene, causing GM1 gangliosidosis (GM1) and Morquio B disease (MBD), respectively, characterized clinical phenotypes as well as biosynthesis, intracellular transport and subcellular localization of mutants.	G(M1) Ganglioside	82-85	galactosidase beta 1	Homo sapiens	38-56
22033734-5	2012	Our previous work on mutations of the beta-galactosidase (beta-gal) gene, causing GM1 gangliosidosis (GM1) and Morquio B disease (MBD), respectively, characterized clinical phenotypes as well as biosynthesis, intracellular transport and subcellular localization of mutants.	G(M1) Ganglioside	82-85	galactosidase beta 1	Homo sapiens	38-46
22289946-0	2012	Intravenous immunoglobulin treatment on anti-GM1 antibodies associated neuropathies inhibits cholera toxin and galectin-1 binding to ganglioside GM1.	G(M1) Ganglioside	145-148	galectin 1	Homo sapiens	111-121
22289946-5	2012	In this observation, we have the result different from the hypothesis of presence of anti-idiotypic antibodies in different IVIg preparations, and show that IVIg inhibits the binding of cholera toxin and galectin-1 to GM1-expressing cells using flow cytometry.	G(M1) Ganglioside	218-221	galectin 1	Homo sapiens	204-214
21978926-5	2012	beta-hexosaminidase and beta-galactosidase cleave specific beta-linked terminal residues from a wide range of glycoconjugates and in particular are involved in the stepwise degradation of GM1 to GM3 ganglioside.	G(M1) Ganglioside	188-191	O-GlcNAcase	Homo sapiens	0-19
22500817-6	2012	Here we demonstrate this aspect by using cholera toxin subunit B (CTB)-ganglioside GM1 (GM1) complexes with different configurations.	G(M1) Ganglioside	83-86	phosphate cytidylyltransferase 1B, choline	Homo sapiens	66-69
22500817-6	2012	Here we demonstrate this aspect by using cholera toxin subunit B (CTB)-ganglioside GM1 (GM1) complexes with different configurations.	G(M1) Ganglioside	88-91	phosphate cytidylyltransferase 1B, choline	Homo sapiens	66-69
22514303-6	2012	The disrupted regulation of DAT 615C parallels a redistribution of the transporter variant away from GM1 ganglioside- and flotillin1-enriched membranes, and is accompanied by altered CaMKII (calcium/calmodulin-dependent protein kinase II) and flotillin-1 interactions.	G(M1) Ganglioside	101-116	solute carrier family 6 member 3	Homo sapiens	28-31
22514303-6	2012	The disrupted regulation of DAT 615C parallels a redistribution of the transporter variant away from GM1 ganglioside- and flotillin1-enriched membranes, and is accompanied by altered CaMKII (calcium/calmodulin-dependent protein kinase II) and flotillin-1 interactions.	G(M1) Ganglioside	101-116	flotillin 1	Homo sapiens	243-254
22524425-7	2012	Cross-linking of GM1 along with associated alpha(4)/alpha(5)beta(1) integrins elicits Ca(2+)-influx via TRPC5 channels as the relevant response for T effector cell (T(eff)) suppression.	G(M1) Ganglioside	17-20	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	104-109
21978926-5	2012	beta-hexosaminidase and beta-galactosidase cleave specific beta-linked terminal residues from a wide range of glycoconjugates and in particular are involved in the stepwise degradation of GM1 to GM3 ganglioside.	G(M1) Ganglioside	188-191	galactosidase beta 1	Homo sapiens	24-42
22235780-8	2012	Correlated with these effects, we observed a distinct clustering of GM1(+) lipid microdomains at the plasma membrane and enhanced phosphorylation of LAT and PKCtheta which may be related to an observed enhancement of Ag-specific effector CD8+ T cell IFN-gamma gene transcription following mild hyperthermia.	G(M1) Ganglioside	68-74	linker for activation of T cells	Homo sapiens	149-152
22235780-8	2012	Correlated with these effects, we observed a distinct clustering of GM1(+) lipid microdomains at the plasma membrane and enhanced phosphorylation of LAT and PKCtheta which may be related to an observed enhancement of Ag-specific effector CD8+ T cell IFN-gamma gene transcription following mild hyperthermia.	G(M1) Ganglioside	68-74	CD8a molecule	Homo sapiens	238-241
22235780-8	2012	Correlated with these effects, we observed a distinct clustering of GM1(+) lipid microdomains at the plasma membrane and enhanced phosphorylation of LAT and PKCtheta which may be related to an observed enhancement of Ag-specific effector CD8+ T cell IFN-gamma gene transcription following mild hyperthermia.	G(M1) Ganglioside	68-74	interferon gamma	Homo sapiens	250-259
22923986-8	2012	It was concluded that the application of ACP1-GM1 for 12 hours might have an efficacy comparable to that of Lamisil( ) Once  for 24 hours, which would resolve the practical problem of the longer administration period that is necessary for Lamisil( ) Once .	G(M1) Ganglioside	46-49	acid phosphatase 1, soluble	Mus musculus	41-45
23050007-7	2012	Neutralizing CXCL10 or depletion of Asialo GM1(+) cells reduced cleaved caspase 3 and TUNEL(+) cells in the liver at day 1 after infection.	G(M1) Ganglioside	43-46	Death executioner caspase related to Apopain/Yama	Drosophila melanogaster	64-81
23430855-8	2012	In cell lines carrying mutations p.N1156S, p.L1191F, p.V1165M, and p.I1061T, the increment of NPC1 mutant protein resulted in an improvement of the intracellular trafficking of cholesterol and GM1.	G(M1) Ganglioside	193-196	NPC intracellular cholesterol transporter 1	Homo sapiens	94-98
22496904-6	2012	The ganglioside, GM1, caused increased association of NGF, TrkA, and microtubules with DRMs, but a decrease in p75(NTR).	G(M1) Ganglioside	17-20	nerve growth factor	Homo sapiens	54-57
22723880-4	2012	We also observed sensitization of the Th1 differentiation machinery through co-localization of IL-2Ralpha, IL-4Ralpha, and IL-12Rbeta2 subunits with GM1 positive lipid rafts, and increased STAT-4 and STAT-5 phosphorylation following membrane cholesterol enrichment.	G(M1) Ganglioside	149-152	interleukin 2 receptor, alpha chain	Mus musculus	95-105
22496904-6	2012	The ganglioside, GM1, caused increased association of NGF, TrkA, and microtubules with DRMs, but a decrease in p75(NTR).	G(M1) Ganglioside	17-20	neurotrophic receptor tyrosine kinase 1	Homo sapiens	59-63
22496904-6	2012	The ganglioside, GM1, caused increased association of NGF, TrkA, and microtubules with DRMs, but a decrease in p75(NTR).	G(M1) Ganglioside	17-20	PC4 and SFRS1 interacting protein 1	Homo sapiens	111-114
22496904-6	2012	The ganglioside, GM1, caused increased association of NGF, TrkA, and microtubules with DRMs, but a decrease in p75(NTR).	G(M1) Ganglioside	17-20	neurotensin receptor 1	Homo sapiens	115-118
21974950-0	2011	A fluorescent probe for GM1 gangliosidosis related beta-galactosidase: N-(dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol.	G(M1) Ganglioside	24-27	beta galactosidase	Drosophila melanogaster	51-69
21974950-1	2011	N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol, a strong competitive inhibitor of beta-galactosidase, enhances residual beta-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant beta-gal as well as aberrant GM1 gangliosides by live cell imaging.	G(M1) Ganglioside	306-322	beta galactosidase	Drosophila melanogaster	110-128
21974950-1	2011	N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol, a strong competitive inhibitor of beta-galactosidase, enhances residual beta-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant beta-gal as well as aberrant GM1 gangliosides by live cell imaging.	G(M1) Ganglioside	306-322	beta galactosidase	Drosophila melanogaster	148-166
21974950-1	2011	N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol, a strong competitive inhibitor of beta-galactosidase, enhances residual beta-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant beta-gal as well as aberrant GM1 gangliosides by live cell imaging.	G(M1) Ganglioside	306-322	beta galactosidase	Drosophila melanogaster	110-118
21913655-4	2011	This study shows by using [9-(3)H]- or [(14)C]sialyl mucin core 2 compounds that ST3Gal-II exchanges sialyl residues between CMP-NeuAc and the NeuAcalpha2,3Galbeta1,3GalNAc unit and also radiolabels sialyl residues in gangliosides GD1a and GT1b, but not GM1.	G(M1) Ganglioside	254-257	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	81-90
22033101-5	2011	The results demonstrated that expression of GM1 and GD1a significantly increased in the ability of anti-EpCAM to inhibit cell growth in SW620 cells.	G(M1) Ganglioside	44-47	epithelial cell adhesion molecule	Homo sapiens	104-109
22033101-9	2011	These results suggest that GD1a and GM1 were closely related to anticancer effects of anti-EpCAM mAb.	G(M1) Ganglioside	36-39	epithelial cell adhesion molecule	Homo sapiens	91-96
22001501-1	2011	GM1 gangliosidosis, a neurodegenerative disorder, and Morquio B disease, a skeletal disorder, are lysosomal storage disorders caused by inherited defects in the enzyme beta-galactosidase (GLB1; EC 3.1.2.23; MIM #611458).	G(M1) Ganglioside	0-3	galactosidase beta 1	Homo sapiens	188-192
21820419-0	2011	The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles.	G(M1) Ganglioside	82-85	tumor protein p63	Homo sapiens	40-43
21820419-5	2011	We have identified the ganglioside GM1 as a high affinity interactor, capable of modulating p63 transcriptional ability exclusively on epidermal target genes.	G(M1) Ganglioside	35-38	tumor protein p63	Homo sapiens	92-95
21820419-7	2011	Therefore, we propose a potential biological role of p63-GM1 interaction in regulation of p63 during epidermal differentiation.	G(M1) Ganglioside	57-60	tumor protein p63	Homo sapiens	53-56
21820419-7	2011	Therefore, we propose a potential biological role of p63-GM1 interaction in regulation of p63 during epidermal differentiation.	G(M1) Ganglioside	57-60	tumor protein p63	Homo sapiens	90-93