PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34097996-4	2021	PFBL constituted of about fifteen different compounds as per LC-MS analysis induced apoptotic death in both androgen-dependent LnCap and androgen-refractory PC3 and DU145 cells with little effect on NKE and WI38 cells.	pfbl	0-4	chromobox 8	Homo sapiens	157-160
34097996-5	2021	Further investigation revealed that PFBL mediates its function through upregulating ROS production by enhanced catalytic activity of monoamine oxidase A (MAO-A).	pfbl	36-40	monoamine oxidase A	Homo sapiens	133-152
34097996-5	2021	Further investigation revealed that PFBL mediates its function through upregulating ROS production by enhanced catalytic activity of monoamine oxidase A (MAO-A).	pfbl	36-40	monoamine oxidase A	Homo sapiens	154-159
34097996-6	2021	Notably, the differential inactivation of NRF2-antioxidant response pathway by PFBL resulted in death in PC3 versus NKE cells involving GSK-3beta activity facilitated by AKT inhibition.	pfbl	79-83	NFE2 like bZIP transcription factor 2	Homo sapiens	42-46
34097996-6	2021	Notably, the differential inactivation of NRF2-antioxidant response pathway by PFBL resulted in death in PC3 versus NKE cells involving GSK-3beta activity facilitated by AKT inhibition.	pfbl	79-83	chromobox 8	Homo sapiens	105-108
34097996-6	2021	Notably, the differential inactivation of NRF2-antioxidant response pathway by PFBL resulted in death in PC3 versus NKE cells involving GSK-3beta activity facilitated by AKT inhibition.	pfbl	79-83	glycogen synthase kinase 3 alpha	Homo sapiens	136-145
34097996-6	2021	Notably, the differential inactivation of NRF2-antioxidant response pathway by PFBL resulted in death in PC3 versus NKE cells involving GSK-3beta activity facilitated by AKT inhibition.	pfbl	79-83	AKT serine/threonine kinase 1	Homo sapiens	170-173
34097996-7	2021	PFBL efficiently reduced the PC3-tumor xenograft in NOD-SCID mice alone and in synergy with Paclitaxel.	pfbl	0-4	chromobox 8	Mus musculus	29-32
34097996-8	2021	Tumor tissues in PFBL-treated mice showed upregulation of similar mechanism of cell death as observed in isolated PC3 cells i.e., elevation of MAO-A catalytic activity, ROS production accompanied by activation of beta-TrCP-GSK-3beta axis of NRF2 degradation.	pfbl	17-21	monoamine oxidase A	Mus musculus	143-148
34097996-8	2021	Tumor tissues in PFBL-treated mice showed upregulation of similar mechanism of cell death as observed in isolated PC3 cells i.e., elevation of MAO-A catalytic activity, ROS production accompanied by activation of beta-TrCP-GSK-3beta axis of NRF2 degradation.	pfbl	17-21	beta-transducin repeat containing protein	Mus musculus	213-222
34097996-8	2021	Tumor tissues in PFBL-treated mice showed upregulation of similar mechanism of cell death as observed in isolated PC3 cells i.e., elevation of MAO-A catalytic activity, ROS production accompanied by activation of beta-TrCP-GSK-3beta axis of NRF2 degradation.	pfbl	17-21	glycogen synthase kinase 3 alpha	Mus musculus	223-232
34097996-8	2021	Tumor tissues in PFBL-treated mice showed upregulation of similar mechanism of cell death as observed in isolated PC3 cells i.e., elevation of MAO-A catalytic activity, ROS production accompanied by activation of beta-TrCP-GSK-3beta axis of NRF2 degradation.	pfbl	17-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	241-245