PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 27055738-10 2016 Cytosol and AKR1C3 exhibit the stereoselective metabolism of (R)-warfarin to preferentially form (SR)-warfarin alcohol as the primary in vivo metabolite of warfarin. 6-hydroxywarfarin 102-118 aldo-keto reductase family 1 member C3 Homo sapiens 12-18 8801056-2 1996 The antifungal agent fluconazole was found to be a potent inhibitor of cytochrome P450 (P450) 2C9 (Ki = 7-8 microM), the principal enzyme responsible for the clearance (85%) of the more potent anticoagulant (S)-warfarin to the inactive (S)-7- and (S)-6-hydroxywarfarin metabolites in vivo. 6-hydroxywarfarin 247-268 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-97 22080016-7 2011 From the results of the inhibition assay, we finally suggest that aldehyde oxidase may mainly contribute to the warfarin alcohol products in chicken cytosol. 6-hydroxywarfarin 112-128 aldehyde oxidase 1 Gallus gallus 66-82 9526963-6 1997 The fluorine substituted warfarins and the S-warfarin alcohol apparently bind with high affinity to CYP2C9. 6-hydroxywarfarin 45-61 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 100-106