PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25465605-1	2014	OBJECTIVE: Dyshormonogenetic congenital hypothyroidism (CH) was reported to be associated with a mutation in the sodium iodide symporter (NIS) gene.	Sodium Iodide	113-126	solute carrier family 5 member 5	Homo sapiens	138-141
25410753-0	2015	Glial fibrillary acidic protein promoters direct adenovirus early 1A gene and human telomerase reverse transcriptase promoters direct sodium iodide symporter expression for malignant glioma radioiodine therapy.	Sodium Iodide	134-147	glial fibrillary acidic protein	Homo sapiens	0-31
25410753-0	2015	Glial fibrillary acidic protein promoters direct adenovirus early 1A gene and human telomerase reverse transcriptase promoters direct sodium iodide symporter expression for malignant glioma radioiodine therapy.	Sodium Iodide	134-147	telomerase reverse transcriptase	Homo sapiens	84-116
25773964-0	2015	A novel hNIS/tdTomato fusion reporter for visualizing the relationship between the cellular localization of sodium iodide symporter and its iodine uptake function under heat shock treatment.	Sodium Iodide	108-121	solute carrier family 5 member 5	Homo sapiens	8-12
25773964-1	2015	The function of membrane-localized sodium iodide symporter (NIS) determines the efficacy of radioiodine therapy in thyroid cancer.	Sodium Iodide	35-48	solute carrier family 5 member 5	Homo sapiens	60-63
25378232-0	2014	B-RafV600E inhibits sodium iodide symporter expression via regulation of DNA methyltransferase 1.	Sodium Iodide	20-33	DNA methyltransferase 1	Homo sapiens	73-96
24708099-1	2014	CONTEXT: The sodium iodide symporter (NIS) mediates active transport of iodide into the thyroid and the lactating mammary glands and is highly expressed in thyroid and breast carcinomas.	Sodium Iodide	13-26	solute carrier family 5 member 5	Homo sapiens	38-41
25309780-1	2014	Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS).	Sodium Iodide	139-152	solute carrier family 5 member 5	Homo sapiens	164-167
24785011-1	2014	BACKGROUND: Sodium iodide ((131)I) therapy for the management of differentiated thyroid cancer is based on the deposition of certain doses of ionizing radiation, which can modulate microRNA (miRNA, miR) expression.	Sodium Iodide	12-25	membrane associated ring-CH-type finger 8	Homo sapiens	191-194
24566185-2	2014	Neuraminidase (NA) inhibitors (NAIs) are the only available therapy for patients infected with influenza B viruses, and the potential emergence of NAI-resistant viruses is a public health concern.	Sodium Iodide	31-35	neuraminidase 1	Homo sapiens	0-13
24445826-1	2014	BACKGROUND: The objective of this study was to estimate the efficacy of the neuraminidase (NA) inhibitors (NAIs) oseltamivir and zanamivir for decreasing viral load and to investigate whether NAI treatment decreases viral susceptibility to NAIs over time in children with influenza B virus infection.	Sodium Iodide	107-111	neuraminidase 1	Homo sapiens	76-89
24445826-1	2014	BACKGROUND: The objective of this study was to estimate the efficacy of the neuraminidase (NA) inhibitors (NAIs) oseltamivir and zanamivir for decreasing viral load and to investigate whether NAI treatment decreases viral susceptibility to NAIs over time in children with influenza B virus infection.	Sodium Iodide	107-110	neuraminidase 1	Homo sapiens	76-89
24445826-1	2014	BACKGROUND: The objective of this study was to estimate the efficacy of the neuraminidase (NA) inhibitors (NAIs) oseltamivir and zanamivir for decreasing viral load and to investigate whether NAI treatment decreases viral susceptibility to NAIs over time in children with influenza B virus infection.	Sodium Iodide	240-244	neuraminidase 1	Homo sapiens	76-89
24566185-2	2014	Neuraminidase (NA) inhibitors (NAIs) are the only available therapy for patients infected with influenza B viruses, and the potential emergence of NAI-resistant viruses is a public health concern.	Sodium Iodide	31-34	neuraminidase 1	Homo sapiens	0-13
23943180-3	2013	acetylcysteine is most often used as an antidote for acetaminophen overdose due to its ability to increase levels of glutathione; however, it is also used to treat NAI-ALF and severe alcoholic hepatitis and to prevent CIN.	Sodium Iodide	164-167	afamin	Homo sapiens	168-171
24645679-7	2014	Finally, we observed that beta-catenin physically interacts with the transcription factor Pax8, increasing its transcriptional activity on the sodium iodide symporter (NIS) gene, a critical gene required for thyroid cell physiology.	Sodium Iodide	143-156	catenin beta 1	Homo sapiens	26-38
24645679-7	2014	Finally, we observed that beta-catenin physically interacts with the transcription factor Pax8, increasing its transcriptional activity on the sodium iodide symporter (NIS) gene, a critical gene required for thyroid cell physiology.	Sodium Iodide	143-156	paired box 8	Homo sapiens	90-94
24243688-1	2014	The BRAF V600E mutation causes impaired expression of sodium iodide symporter (NIS) and radioiodine refractoriness of thyroid cancer, but the underlying mechanism remains undefined.	Sodium Iodide	54-67	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	4-8
23819433-4	2014	METHODS: The in vitro and in vivo effects of AMPK modulation on sodium-iodide symporter (NIS) protein levels and iodide uptake were examined in follicular rat thyroid cell-line cells and C57Bl6/J mice.	Sodium Iodide	64-77	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	45-49
24193032-1	2013	We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of combined radiovirotherapy after systemic delivery of the theranostic sodium iodide symporter (NIS) gene using a dendrimer-coated adenovirus.	Sodium Iodide	152-165	solute carrier family 5 member 5	Homo sapiens	177-180
24054501-2	2013	METHODS: The Huh 7/NTG stable cell line was established by transfection of a vector with the human sodium iodide symporter (hNIS), HSV1-sr39 thymidine kinase (tk), and enhanced green florescent protein (EGFP) fusion gene into Huh 7 cells.	Sodium Iodide	99-112	MIR7-3 host gene	Homo sapiens	13-18
24054501-2	2013	METHODS: The Huh 7/NTG stable cell line was established by transfection of a vector with the human sodium iodide symporter (hNIS), HSV1-sr39 thymidine kinase (tk), and enhanced green florescent protein (EGFP) fusion gene into Huh 7 cells.	Sodium Iodide	99-112	solute carrier family 5 member 5	Homo sapiens	124-128
24052075-0	2013	The sodium/iodide symporter NIS is a transcriptional target of the p53-family members in liver cancer cells.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	28-31
24052075-0	2013	The sodium/iodide symporter NIS is a transcriptional target of the p53-family members in liver cancer cells.	Sodium Iodide	4-17	tumor protein p53	Homo sapiens	67-70
24884806-0	2014	Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer.	Sodium Iodide	0-13	solute carrier family 5 member 5	Homo sapiens	25-28
24884806-1	2014	BACKGROUND: Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia.	Sodium Iodide	39-52	solute carrier family 5 member 5	Homo sapiens	64-67
24369144-0	2014	Radioiodine therapy for castration-resistant prostate cancer following prostate-specific membrane antigen promoter-mediated transfer of the human sodium iodide symporter.	Sodium Iodide	146-159	folate hydrolase 1	Homo sapiens	71-105
24369144-1	2014	Radioiodine therapy, the most effective form of systemic radiotherapy available, is currently useful only for thyroid cancer because of the thyroid-specific expression of the human sodium iodide symporter (hNIS).	Sodium Iodide	181-194	solute carrier family 5 member 5	Homo sapiens	206-210
23677652-1	2013	PURPOSE: The purpose of this study is to visualize the migration of reporter macrophages expressing both the human sodium iodide symporter (hNIS) and enhanced firefly luciferase (effluc) gene in mice with chemically induced inflammation.	Sodium Iodide	115-128	solute carrier family 5 member 5	Homo sapiens	140-144
24098053-1	2013	NOD.H-2h4 mice given NaI in their drinking water develop iodine-accelerated spontaneous autoimmune thyroiditis (ISAT) with chronic inflammation of the thyroid by T and B cells and production of anti-mouse thyroglobulin (MTg) autoantibody.	Sodium Iodide	21-24	thyroglobulin	Mus musculus	205-218
23986517-7	2013	We found that the ouabain-sensitive rise in Nai in TALs from ANG II-infused rats was 12.8 +- 0.4 arbitrary fluorescent units (AFU) mg(-1) min(-1) compared with only 9.9 +- 1.1 AFU mg(-1) min(-1) in controls (P < 0.024).	Sodium Iodide	44-47	angiotensinogen	Rattus norvegicus	61-67
22998776-1	2013	BACKGROUND: The BRAF(V600E) mutation is present in 62% of radioactive iodine-resistant thyroid tumors and is associated with downregulation of the sodium-iodide symporter (NIS) and thyroid stimulating hormone receptor (TSHr).	Sodium Iodide	147-160	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	16-21
23471296-8	2013	Iodide also inhibits endogenous TRPM7-like currents as assessed in MCF-7 breast cancer cells, where upregulation of SLC5A5 sodium-iodide symporter enhances iodide uptake and inhibits cell proliferation.	Sodium Iodide	123-136	transient receptor potential cation channel subfamily M member 7	Homo sapiens	32-37
23471296-8	2013	Iodide also inhibits endogenous TRPM7-like currents as assessed in MCF-7 breast cancer cells, where upregulation of SLC5A5 sodium-iodide symporter enhances iodide uptake and inhibits cell proliferation.	Sodium Iodide	123-136	solute carrier family 5 member 5	Homo sapiens	116-122
23541638-2	2013	In this study, we developed a radionuclide imaging system for miR-9 using sodium iodide symporter (NIS).	Sodium Iodide	74-87	membrane associated ring-CH-type finger 8	Homo sapiens	62-65
23541638-2	2013	In this study, we developed a radionuclide imaging system for miR-9 using sodium iodide symporter (NIS).	Sodium Iodide	74-87	solute carrier family 5 member 5	Homo sapiens	99-102
24135055-1	2013	IFN-gamma(-/-) NOD.H-2h4 mice develop a spontaneous autoimmune thyroid disease, thyroid epithelial cell hyperplasia and proliferation (TEC H/P) when given NaI in their water for 7+ mo.	Sodium Iodide	155-158	interferon gamma	Mus musculus	0-18
23038026-0	2013	Sodium iodide symporter (NIS)-mediated radiovirotherapy of hepatocellular cancer using a conditionally replicating adenovirus.	Sodium Iodide	0-13	solute carrier family 5 member 5	Homo sapiens	25-28
23038026-1	2013	In this study, we determined the in vitro and in vivo efficacy of sodium iodide symporter (NIS) gene transfer and the therapeutic potential of oncolytic virotherapy combined with radioiodine therapy using a conditionally replicating oncolytic adenovirus.	Sodium Iodide	66-79	solute carrier family 5 member 5	Homo sapiens	91-94
22998776-1	2013	BACKGROUND: The BRAF(V600E) mutation is present in 62% of radioactive iodine-resistant thyroid tumors and is associated with downregulation of the sodium-iodide symporter (NIS) and thyroid stimulating hormone receptor (TSHr).	Sodium Iodide	147-160	thyroid stimulating hormone receptor	Homo sapiens	219-223
23542164-1	2013	The uptake of iodide into the thyroid, an essential step in thyroid hormone synthesis, is an active process mediated by the sodium-iodide symporter (NIS).	Sodium Iodide	124-137	solute carrier family 5 member 5	Rattus norvegicus	149-152
23404348-1	2013	Gene therapy using human sodium iodide symporter (hNIS) and radioiodine             has been considered promising in a variety of gene therapy trials.	Sodium Iodide	25-38	solute carrier family 5 member 5	Homo sapiens	50-54
23522027-2	2013	Here, we investigated the cytotoxic and phenotypic modulation effects of the combination of ANT2 shRNA and human sodium iodide symporter (hNIS) radioiodine gene therapy in vitro and in vivo and visualized the antitumor effects in an immunocompromised mouse colon cancer model.	Sodium Iodide	113-126	solute carrier family 5 member 5	Homo sapiens	138-142
23342072-0	2013	Quantitative immunohistochemical analysis reveals association between sodium iodide symporter and estrogen receptor expression in breast cancer.	Sodium Iodide	70-83	estrogen receptor 1	Homo sapiens	98-115
23506710-3	2013	The human sodium iodide symporter (hNIS) is a naturally occurring protein in human thyroid tissue, which enables cells to concentrate radionuclides.	Sodium Iodide	10-23	solute carrier family 5 member 5	Homo sapiens	35-39
23795507-10	2013	However, the degree of ionic absorption within the brush is again ion specific n the order NaCl > NaBr > NaI > NaF at 1 m salt concentration.	Sodium Iodide	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	120-123
24895502-0	2013	In vitro radionuclide therapy and in vivo scintigraphic imaging of alpha-fetoprotein-producing hepatocellular carcinoma by targeted sodium iodide symporter gene expression.	Sodium Iodide	132-145	alpha fetoprotein	Homo sapiens	67-84
24895502-1	2013	PURPOSE: This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human sodium/iodide symporter (hNIS) gene driven by an AFP enhancer/promoter.	Sodium Iodide	228-241	alpha fetoprotein	Homo sapiens	108-125
24895502-1	2013	PURPOSE: This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human sodium/iodide symporter (hNIS) gene driven by an AFP enhancer/promoter.	Sodium Iodide	228-241	alpha fetoprotein	Homo sapiens	127-130
24895502-1	2013	PURPOSE: This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human sodium/iodide symporter (hNIS) gene driven by an AFP enhancer/promoter.	Sodium Iodide	228-241	solute carrier family 5 member 5	Homo sapiens	253-257
24895502-1	2013	PURPOSE: This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human sodium/iodide symporter (hNIS) gene driven by an AFP enhancer/promoter.	Sodium Iodide	228-241	alpha fetoprotein	Homo sapiens	277-280
22982218-1	2013	Since PARP-1 is supposed to be part of a multimeric repressor of sodium iodide symporter (NIS) expression, in this study the effect of the PARP inhibitor PJ34 on several properties of thyroid cancer cell lines was investigated.	Sodium Iodide	65-78	poly(ADP-ribose) polymerase 1	Homo sapiens	6-12
23037808-1	2012	The sodium-iodide symporter (NIS) directs the uptake and concentration of iodide in thyroid cells.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
22663767-5	2012	Phosphorylation of Prdx6 changed the conformation of the N-terminal domain exposing Trp 33, as determined by tryptophan fluorescence and NaI fluorescence quenching.	Sodium Iodide	137-140	peroxiredoxin 6	Homo sapiens	19-24
23181221-6	2012	The sodium-iodide symporter (NIS) is responsible for the ability of the thyroid gland to transport and concentrate iodide.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
22995901-0	2012	Alpha-lipoic acid induces sodium iodide symporter expression in TPC-1 thyroid cancer cell line.	Sodium Iodide	26-39	two pore segment channel 1	Homo sapiens	64-69
22750642-0	2012	The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
22750642-1	2012	Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in thyroid and lactating breast.	Sodium Iodide	18-31	solute carrier family 5 member 5	Homo sapiens	43-46
22790962-1	2012	Anaplastic thyroid cancer is an extremely aggressive disease resistant to radioiodine treatment because of loss of sodium iodide symporter (NIS) expression.	Sodium Iodide	115-128	solute carrier family 5 member 5	Homo sapiens	140-143
22510021-1	2012	BACKGROUND: Comprehension of the regulatory mechanism involved in the sodium iodide symporter (NIS) expression is of great relevance for thyroid cancer.	Sodium Iodide	70-83	solute carrier family 5 member 5	Homo sapiens	95-98
22154648-3	2012	It has been proven that these physics and treatments work well for 3x3"" and 6x6"" cylindrical NaI detector in CEAR"s previous work.	Sodium Iodide	95-98	heterogeneous nuclear ribonucleoprotein M	Homo sapiens	111-115
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Sodium Iodide	172-185	transcription termination factor 1	Homo sapiens	53-59
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Sodium Iodide	172-185	paired box 8	Homo sapiens	64-69
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Sodium Iodide	172-185	thyroglobulin	Homo sapiens	218-220
22535767-2	2012	The sodium iodide symporter (NIS) delivers iodide from the bloodstream into the thyroid, and after TH biosynthesis, monocarboxylate transporter 8 (MCT8) mediates TH secretion from the thyroid gland.	Sodium Iodide	4-17	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	116-145
22535767-2	2012	The sodium iodide symporter (NIS) delivers iodide from the bloodstream into the thyroid, and after TH biosynthesis, monocarboxylate transporter 8 (MCT8) mediates TH secretion from the thyroid gland.	Sodium Iodide	4-17	solute carrier family 16 (monocarboxylic acid transporters), member 2	Mus musculus	147-151
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Sodium Iodide	172-185	thyroid peroxidase	Homo sapiens	223-238
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Sodium Iodide	172-185	thyroid peroxidase	Homo sapiens	240-243
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Sodium Iodide	172-185	transcription termination factor 1	Homo sapiens	450-455
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Sodium Iodide	172-185	paired box 8	Homo sapiens	460-465
21833035-1	2012	The thyroid transcription factor Pax-8 could bind with the promoter/enhancer of thyroid-specific genes such as thyroglobulin (Tg), thyroperoxidase (TPO) and sodium iodide symporter (NIS), and regulate the expression of these proteins in thyrocyte.	Sodium Iodide	157-170	paired box 8	Homo sapiens	33-38
21993965-0	2012	Changes of sodium iodide symporter regulated by IGF-I and TGF-beta1 in mammary gland cells from lactating mice at different iodine levels.	Sodium Iodide	11-24	insulin-like growth factor 1	Mus musculus	48-53
21993965-0	2012	Changes of sodium iodide symporter regulated by IGF-I and TGF-beta1 in mammary gland cells from lactating mice at different iodine levels.	Sodium Iodide	11-24	transforming growth factor, beta 1	Mus musculus	58-67
22274627-10	2012	CRR7 is likely to be involved in the final step, in which the fully assembled NAI, including NdhN, is inserted into thylakoids.	Sodium Iodide	78-81	chlororespiratory reduction 7	Arabidopsis thaliana	0-4
22522436-5	2012	Furthermore, PTTG over-expression negatively impacts upon the efficacy of radioiodine therapy in thyroid cancer, through repression of expression and function of the sodium iodide symporter.	Sodium Iodide	166-179	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	13-17
22178794-5	2012	SLC26A4 mRNA expression was also investigated in PCCl3 cells treated with actinomycin D prior to NaI treatment.	Sodium Iodide	97-100	solute carrier family 26 member 4	Rattus norvegicus	0-7
22185260-0	2012	Effective radiovirotherapy for malignant gliomas by using oncolytic measles virus strains encoding the sodium iodide symporter (MV-NIS).	Sodium Iodide	103-116	solute carrier family 5 member 5	Homo sapiens	131-134
22185260-2	2012	In this study, we have demonstrated that MV strains genetically engineered to express the human sodium iodide symporter (NIS) have significant antitumor activity against glioma lines and orthotopic xenografts; this compares favorably with the MV strain expressing the human carcinoembryonic antigen, which is currently in clinical testing.	Sodium Iodide	96-109	solute carrier family 5 member 5	Homo sapiens	121-124
22781452-1	2012	OBJECTIVE: To explore the effects of nevirapine on the proliferation and expression of sodium-iodide symporter (NIS) mRNA in FRO cells in vitro.	Sodium Iodide	87-100	solute carrier family 5 member 5	Homo sapiens	112-115
22157753-0	2012	Regulation of sodium iodide symporter gene expression by Rac1/p38beta mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells.	Sodium Iodide	14-27	Rac family small GTPase 1	Homo sapiens	57-61
22157753-0	2012	Regulation of sodium iodide symporter gene expression by Rac1/p38beta mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells.	Sodium Iodide	14-27	mitogen-activated protein kinase 11	Homo sapiens	62-69
23163107-0	2012	Prognostic prediction of BRAF(V600E) and its relationship with sodium iodide symporter in classic variant of papillary thyroid carcinomas.	Sodium Iodide	63-76	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	25-30
22050638-4	2011	In addition, NIS (sodium-iodide symporter) gene expression was measured on 34 of the pathological thyroid samples.	Sodium Iodide	18-31	solute carrier family 5 member 5	Homo sapiens	13-16
22912675-3	2012	This study aims to determine the in vivo biodistribution, and imaging and timing characteristics of a vaccinia virus, GLV-1h153, encoding the human sodium iodide symporter (hNIS.	Sodium Iodide	148-161	solute carrier family 5 member 5	Homo sapiens	173-177
22719903-4	2012	METHODS AND FINDINGS: TSC2-deficient human cells, derived from the angiomyolipoma of a LAM patient, were engineered to co-express both sodium-iodide symporter (NIS) and green fluorescent protein (GFP).	Sodium Iodide	135-148	TSC complex subunit 2	Homo sapiens	22-26
22276177-3	2012	The purposes of this study were to investigate whether 1) intravenously administered, genetically transformed cord blood derived EPCs can carry human sodium iodide symporter (hNIS) to the sites of tumors in rat orthotopic model of human glioma and express transgene products, and 2) whether accumulation of these administered EPCs can be tracked by different in vivo imaging modalities.	Sodium Iodide	150-163	solute carrier family 5 member 5	Homo sapiens	175-179
22003972-2	2011	The human sodium iodide symporter (hNIS) gene is a useful reporter gene for tumor imaging and radiotherapy.	Sodium Iodide	10-23	solute carrier family 5 member 5	Homo sapiens	35-39
21844185-3	2011	Expression of the sodium iodide symporter (NIS), a gene essential to the radioiodine ablation of thyroid hyperplasia, neoplasia, and metastasis, was also potently inhibited in PBF-Tg mice.	Sodium Iodide	18-31	pituitary tumor-transforming 1 interacting protein	Mus musculus	176-179
21488714-0	2011	Sodium iodide symporter (NIS)-mediated radionuclide ((131)I, (188)Re) therapy of liver cancer after transcriptionally targeted intratumoral in vivo NIS gene delivery.	Sodium Iodide	0-13	solute carrier family 5 member 5	Homo sapiens	25-28
21488714-0	2011	Sodium iodide symporter (NIS)-mediated radionuclide ((131)I, (188)Re) therapy of liver cancer after transcriptionally targeted intratumoral in vivo NIS gene delivery.	Sodium Iodide	0-13	solute carrier family 5 member 5	Homo sapiens	148-151
21488714-1	2011	We reported the therapeutic efficacy of (131)I in hepatocellular carcinoma (HCC) cells stably expressing the sodium iodide symporter (NIS) under the control of the tumor-specific alpha-fetoprotein (AFP) promoter.	Sodium Iodide	109-122	solute carrier family 5 member 5	Homo sapiens	134-137
21488714-1	2011	We reported the therapeutic efficacy of (131)I in hepatocellular carcinoma (HCC) cells stably expressing the sodium iodide symporter (NIS) under the control of the tumor-specific alpha-fetoprotein (AFP) promoter.	Sodium Iodide	109-122	alpha fetoprotein	Homo sapiens	179-196
21488714-1	2011	We reported the therapeutic efficacy of (131)I in hepatocellular carcinoma (HCC) cells stably expressing the sodium iodide symporter (NIS) under the control of the tumor-specific alpha-fetoprotein (AFP) promoter.	Sodium Iodide	109-122	alpha fetoprotein	Homo sapiens	198-201
21994409-1	2011	UNLABELLED: The purpose of this study was to investigate the enhanced therapeutic effect of the combined use of shRNA (small hairpin RNA) therapy for the hexokinase II (HKII) gene and (131)I human sodium iodide symporter (hNIS) as a gene therapy for in vitro and in vivo treatment of anaplastic thyroid carcinoma cells (ARO) in an animal model.	Sodium Iodide	197-210	solute carrier family 5 member 5	Homo sapiens	222-226
21797672-2	2011	In principle, undifferentiated thyroid cancers as well as nonthyroid cancers can concentrate and, thus, be treated with radioiodine after transfection with the human sodium iodide symporter (hNIS) gene.	Sodium Iodide	166-179	solute carrier family 5 member 5	Homo sapiens	191-195
22234102-1	2011	BACKGROUND: Sodium iodide symporter (NIS), a transporter of iodine is essential for thyroid hormone biosynthesis.	Sodium Iodide	12-25	solute carrier family 5 member 5	Homo sapiens	37-40
21608083-2	2011	This study aimed to introduce MSC-mediated expression of the sodium iodide symporter (NIS) for imaging and therapy of breast cancer.	Sodium Iodide	61-74	solute carrier family 5 member 5	Homo sapiens	86-89
21587209-1	2011	We have developed a replication-competent adenovirus (Ad5-yCD/mutTK(SR39)rep-hNIS) armed with two suicide genes and the human sodium iodide symporter (hNIS) gene.	Sodium Iodide	126-139	solute carrier family 5 member 5	Homo sapiens	151-155
21702220-3	2011	The iodide is transported inside the thyroid epithelial cell via sodium iodide symporter (NIS) which is a trans-membrane protein.	Sodium Iodide	65-78	solute carrier family 5 member 5	Homo sapiens	90-93
21386735-1	2011	OBJECTIVE: Increased expression of sodium iodide symporter (NIS) is required for reporter gene imaging and effective radioiodine treatment of tumor.	Sodium Iodide	35-48	solute carrier family 5 member 5	Homo sapiens	60-63
20213084-0	2010	The pan-DAC inhibitor LBH589 is a multi-functional agent in breast cancer cells: cytotoxic drug and inducer of sodium-iodide symporter (NIS).	Sodium Iodide	111-124	arylacetamide deacetylase	Homo sapiens	8-11
21453532-3	2011	This study aimed to determine if insertion of the human sodium iodide symporter (hNIS) cDNA as a marker for non-invasive imaging of virotherapy alters the replication and oncolytic capability of a novel vaccinia virus, GLV-1h153.	Sodium Iodide	56-69	solute carrier family 5 member 5	Homo sapiens	81-85
21364918-3	2011	Recently, Hes1 was shown to be expressed in the thyroid and regulate expression of the sodium iodide symporter (Nis).	Sodium Iodide	87-100	hes family bHLH transcription factor 1	Mus musculus	10-14
21428212-0	2011	Human sodium iodide symporter (hNIS) in fibroadenoma breast--a immunohistochemical study.	Sodium Iodide	6-19	solute carrier family 5 member 5	Homo sapiens	31-35
21428212-1	2011	Human sodium iodide symporter (hNIS), responsible for the active transport of iodine is an integral plasma membrane glycoprotein present in the thyroid cells and extrathyroid tissues like breast and salivary glands.	Sodium Iodide	6-19	solute carrier family 5 member 5	Homo sapiens	31-35
21315285-0	2011	Reduction of stimulated sodium iodide symporter expression by estrogen receptor ligands in breast cancer cells.	Sodium Iodide	24-37	estrogen receptor 1 (alpha)	Mus musculus	62-79
21220132-0	2011	Evaluation of the therapeutic efficacy of a VEGFR2-blocking antibody using sodium-iodide symporter molecular imaging in a tumor xenograft model.	Sodium Iodide	75-88	kinase insert domain protein receptor	Mus musculus	44-50
21245850-0	2011	Epidermal growth factor receptor-targeted (131)I-therapy of liver cancer following systemic delivery of the sodium iodide symporter gene.	Sodium Iodide	108-121	epidermal growth factor receptor	Homo sapiens	0-32
20961282-1	2010	OBJECTIVES: This study aimed to analyze both the level and the cell site of the sodium-iodide symporter (NIS) protein expression in autonomously functioning thyroid nodules (AFTNs) and extranodular thyroid tissues.	Sodium Iodide	80-93	solute carrier family 5 member 5	Homo sapiens	105-108
21072902-1	2010	AIM: To investigate the feasibility of radionuclide therapy of colon tumor cells by baculovirus vector-mediated transfer of the sodium/iodide symporter (NIS) gene.	Sodium Iodide	128-141	solute carrier family 5 member 5	Homo sapiens	153-156
20942455-1	2010	The influence of the salts KCl, NaCl, and NaI at molar concentrations on the alpha-helical folding kinetics of the alanine-based oligopeptide Ace-AEAAAKEAAAKA-Nme is investigated by means of (explicit-water) molecular dynamics simulations and a diffusional analysis.	Sodium Iodide	42-45	angiotensin I converting enzyme	Homo sapiens	142-145
20428214-0	2010	A probasin promoter, conditionally replicating adenovirus that expresses the sodium iodide symporter (NIS) for radiovirotherapy of prostate cancer.	Sodium Iodide	77-90	solute carrier family 5 member 5	Homo sapiens	102-105
20428214-1	2010	The sodium iodide symporter (NIS) directs the uptake and concentration of iodide in thyroid cells.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
20847173-1	2010	UNLABELLED: The aim of this study was to investigate the feasibility of nuclear molecular imaging using the human sodium iodide symporter (hNIS) as a reporter gene to monitor macrophage migration toward the inflammatory foci.	Sodium Iodide	114-127	solute carrier family 5 member 5	Homo sapiens	139-143
20683361-1	2010	OBJECTIVE: Increased expression of sodium/iodide symporter (NIS) is required for reporter gene imaging and effective radioiodine treatment of tumor.	Sodium Iodide	35-48	solute carrier family 5 member 5	Homo sapiens	60-63
20228127-1	2010	Radioiodine remains the only tumoricidal therapy for disseminated thyroid carcinomas; however, dedifferentiated tumors lose the expression of human sodium-iodide symporter (hNIS) gene, and cannot respond to this treatment.	Sodium Iodide	148-161	solute carrier family 5 member 5	Homo sapiens	173-177
20819544-0	2010	Adenovirus-mediated and tumor-specific transgene expression of the sodium-iodide symporter from the human telomerase reverse transcriptase promoter enhances killing of lung cancer cell line in vitro.	Sodium Iodide	67-80	telomerase reverse transcriptase	Homo sapiens	106-138
20819544-3	2010	We constructed a recombinant adenovirus containing the human sodium iodide symporter (hNIS) gene directed by the hTERT promoter, characterized the ability of infected cells in uptaking iodide, and explored the therapeutic efficacy of (131)I in a lung cancer cell line in vitro.	Sodium Iodide	61-74	telomerase reverse transcriptase	Homo sapiens	113-118
20427476-5	2010	1 was active under more physiologically relevant conditions in primary cultures of human thyrocytes expressing endogenous TSHRs where it inhibited basal levels of mRNA transcripts for thyroglobulin, thyroperoxidase, sodium iodide symporter, and TSHR.	Sodium Iodide	216-229	thyroid stimulating hormone receptor	Homo sapiens	122-126
20010437-2	2010	This is because overwhelming evidence is consistent with the hypothesis that myocardial ischemic injury results in part from increases in intracellular Na (Nai) mediated by NHE1 that in turn promote Na/Ca exchanger-mediated increases in intracellular Ca ([Ca]i) and Ca-dependent cell damage.	Sodium Iodide	156-159	sodium/hydrogen exchanger 1	Oryctolagus cuniculus	173-177
24899932-2	2010	Iodide uptake occurs across the membrane of the thyroid follicular cells and cancer cells through an active transporter process mediated by the sodium iodide symporter (NIS).	Sodium Iodide	144-157	solute carrier family 5 member 5	Homo sapiens	169-172
20010437-13	2010	In conclusion, NHE1 inhibition diminishes ischemia-induced increases in Nai and therefore [Ca], and thus diminishes myocardial injury in neonatal hearts.	Sodium Iodide	72-75	sodium/hydrogen exchanger 1	Oryctolagus cuniculus	15-19
19954867-4	2010	Treatment of a solution containing labeling precursors with [(124)I]NaI gave radiolabeled Cdk4 inhibitors [(124)I]CKIA and [(124)I]CKIB in radiochemical yields of up to 35%.	Sodium Iodide	68-71	cyclin-dependent kinase 4	Rattus norvegicus	90-94
19689456-10	2009	Genes differentially expressed in the drug-nai ve state, including Slc6a4 (serotonin transporter), Htr3a (serotonin receptor 3A), Rela [nuclear factor kappaB (NFkappaB)] and Fos (cFos), represent candidates whose expression levels may predict methamphetamine consumption and susceptibility to methamphetamine reward and aversion.	Sodium Iodide	43-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-169
19727716-0	2010	Wild-type p53 enhances the cytotoxic effect of radionuclide gene therapy using sodium iodide symporter in a murine anaplastic thyroid cancer model.	Sodium Iodide	79-92	transformation related protein 53, pseudogene	Mus musculus	10-13
19618116-2	2010	The sodium iodide symporter, NIS, actively transports iodide across the plasma membrane and is exploited clinically to deliver radioactive iodide into cells.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
19916865-1	2009	BACKGROUND: Iodide transport defects (ITDs), rare causes of congenital hypothyroidism (CH), have been shown to arise from abnormalities of the sodium/iodide symporter (NIS).	Sodium Iodide	143-156	solute carrier family 5 member 5	Homo sapiens	168-171
19706820-5	2009	EXPERIMENTAL DESIGN: To target systemically administered radioiodide to tumors, we created Ad5/3-Delta24-human sodium iodide symporter (hNIS), a Rb-p16 pathway selective infectivity enhanced oncolytic adenovirus encoding hNIS.	Sodium Iodide	111-124	Alzheimer disease, familial, type 5	Homo sapiens	91-94
19754085-1	2009	A kinetic study of the aroxyl (ArO*) radical-scavenging reaction of alpha-tocopherol (alpha-TocH) has been performed in the presence of six kinds of alkali and alkaline earth metal salts (LiI, LiClO(4), NaI, NaClO(4), KI, and Mg(ClO(4))(2)) in methanol solution, using stopped-flow spectrophotometry.	Sodium Iodide	203-206	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	31-35
19754085-3	2009	The second-order rate constants (k(s)) for the reaction of alpha-TocH with ArO* increased in the order of no metal salt < KI approximately NaClO(4) approximately NaI <or= LiClO(4) < Mg(ClO(4))(2) < LiI at the same concentration of metal salts.	Sodium Iodide	165-168	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	75-79
19196800-0	2009	Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid.	Sodium Iodide	16-29	solute carrier family 5 member 5	Homo sapiens	40-43
19525455-3	2009	METHODS: Human endothelial progenitor cells (HEPCs), derived from CD34+ mononuclear cells of umbilical cord blood, were retrovirally transduced with the sodium iodide symporter (NIS) gene for reporter gene imaging by (124)I-PET and labeled with iron oxides for visualization by MRI.	Sodium Iodide	153-166	CD34 molecule	Homo sapiens	66-70
19525464-3	2009	Furthermore, recent in vitro studies indicate that (131)I irradiation reduces iodide uptake by downregulating the expression of the sodium iodide symporter (NIS).	Sodium Iodide	132-145	solute carrier family 5 member 5	Homo sapiens	157-160
19355751-1	2009	The structure of aqueous LiCl, NaCl, KCl, CsCl, KF, and NaI solutions is calculated by molecular dynamics (MD) simulations of the frequently employed Dang force-field in SPC/E water.	Sodium Iodide	56-59	proline rich protein gene cluster	Homo sapiens	170-173
19327159-3	2009	In this study, we used superparamagentic iron oxide (SPIO)-labeled APCs to carry the human sodium iodide symporter (hNIS) gene to the sites of implanted breast cancer in mouse model.	Sodium Iodide	91-104	amyloid P component, serum	Homo sapiens	67-71
19327159-3	2009	In this study, we used superparamagentic iron oxide (SPIO)-labeled APCs to carry the human sodium iodide symporter (hNIS) gene to the sites of implanted breast cancer in mouse model.	Sodium Iodide	91-104	solute carrier family 5 member 5	Homo sapiens	116-120
19241193-1	2009	The sodium iodide symporter (NIS) present in the membranes of thyroid cells is responsible for the capacity of the thyroid to concentrate iodide.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
18759560-2	2008	The sodium iodide symporter (NIS), which has recognized therapeutic and reporter gene properties, is appropriate to evaluate the transcriptional strength and specificity of the HIP promoter in HCC.	Sodium Iodide	4-17	regenerating family member 3 alpha	Homo sapiens	177-180
19098211-1	2009	OBJECTIVE: Our objectives were to, first, determine the oncolytic potential of an engineered measles virus expressing the sodium-iodide symporter gene (MV-NIS) for intratumoral (i.t.)	Sodium Iodide	122-135	solute carrier family 5 member 5	Homo sapiens	155-158
18835410-2	2009	In contrast to M2 blockers, resistance to neuraminidase (NA) inhibitors (NAIs) is subtype- and drug-specific.	Sodium Iodide	73-77	neuraminidase 1	Homo sapiens	42-55
19635153-0	2009	Construction of an MUC-1 promoter driven, conditionally replicating adenovirus that expresses the sodium iodide symporter for gene therapy of breast cancer.	Sodium Iodide	98-111	mucin 1, cell surface associated	Homo sapiens	19-24
19050049-8	2009	Pendrin antibodies correlated significantly with thyroglobulin, thyroperoxidase, and sodium iodide symporter antibodies but not with TSH receptor antibodies.	Sodium Iodide	85-98	solute carrier family 26 member 4	Homo sapiens	0-7
18714306-1	2008	To monitor noninvasively potentially therapeutic adenoviruses for cancer, we have developed a methodology based on the sodium iodide symporter (NIS).	Sodium Iodide	119-132	solute carrier family 5 member 5	Homo sapiens	144-147
18703592-0	2008	Visualization of hypoxia-inducible factor-1 transcriptional activation in C6 glioma using luciferase and sodium iodide symporter genes.	Sodium Iodide	105-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-43
18703598-1	2008	UNLABELLED: We investigated the feasibility of using combination gene therapy and noninvasive nuclear imaging after expression of the human sodium iodide symporter (hNIS) and inhibition of the multidrug resistance (MDR1) gene in colon cancer cells.	Sodium Iodide	140-153	solute carrier family 5 member 5	Homo sapiens	165-169
18404268-1	2008	PURPOSE: We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)I.	Sodium Iodide	157-170	kallikrein related peptidase 3	Homo sapiens	107-138
18470848-1	2008	The ability of the sodium/iodide symporter (NIS) to take up iodide has long provided the basis for cytoreductive gene therapy and cancer treatment with radioiodide.	Sodium Iodide	19-32	solute carrier family 5 member 5	Homo sapiens	44-47
18421306-1	2008	Expression of the sodium iodide symporter (hNIS) has been detected in breast cancer tissue, but frequently, not at the levels necessary to mediate (131)I accumulation.	Sodium Iodide	18-31	solute carrier family 5 member 5	Homo sapiens	43-47
18641364-1	2008	IFN-gamma(-/-)NOD.H-2h4 mice given 0.05% NaI in their water develop severe thyroid epithelial cell (thyrocyte) hyperplasia and proliferation (TEC H/P) and fibrosis.	Sodium Iodide	41-44	interferon gamma	Mus musculus	0-9
18404268-1	2008	PURPOSE: We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)I.	Sodium Iodide	157-170	solute carrier family 5 member 5	Homo sapiens	182-185
18345682-2	2008	The reaction was found to be catalyzed at 0 degrees C using either a Sc(OTf)3/NaI system or ScI3.	Sodium Iodide	78-81	POU class 5 homeobox 1	Homo sapiens	69-77
18205108-1	2007	The sodium iodide symporter, called also the NIS protein is responsible for iodine trapping to the cell what is significant for the thyroid function.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	45-48
18165779-0	2007	Sodium iodide symporter (hNIS) permits molecular imaging of gene transduction in cardiac transplantation.	Sodium Iodide	0-13	solute carrier family 5 member 5	Homo sapiens	25-29
17960161-4	2007	Here, we use the human sodium iodide symporter (hNIS) as a reporter gene in wild-type and replication-selective adenoviruses.	Sodium Iodide	23-36	solute carrier family 5 member 5	Homo sapiens	48-52
18004977-6	2007	Only one line had thyroid-targeted, doxycycline-regulated RET/PTC1 and luciferase coexpression, in which doxycycline induction of RET/PTC1 led to Erk phosphorylation and reduced expression of the sodium/iodide symporter (NIS).	Sodium Iodide	196-209	ret proto-oncogene	Mus musculus	130-133
17989705-0	2008	Alpha-fetoprotein promoter-targeted sodium iodide symporter gene therapy of hepatocellular carcinoma.	Sodium Iodide	36-49	alpha fetoprotein	Mus musculus	0-17
18203958-0	2008	Dual effect of Nai+ on Ca2+ influx through the Na+/Ca2+ exchanger in dialyzed squid axons.	Sodium Iodide	15-19	solute carrier family 8 member A1	Homo sapiens	47-65
18205108-3	2007	Existing studies on the sodium iodide symporter include among others: indicating NIS protein expression in the thyroid diseases and extrathyroidal tissues, studying of the NIS antygenicity in the autoimmune diseases of thyroid, finding the molecular aspects of the difference in the NIS protein activity.	Sodium Iodide	24-37	solute carrier family 5 member 5	Homo sapiens	81-84
18205108-3	2007	Existing studies on the sodium iodide symporter include among others: indicating NIS protein expression in the thyroid diseases and extrathyroidal tissues, studying of the NIS antygenicity in the autoimmune diseases of thyroid, finding the molecular aspects of the difference in the NIS protein activity.	Sodium Iodide	24-37	solute carrier family 5 member 5	Homo sapiens	172-175
18205108-3	2007	Existing studies on the sodium iodide symporter include among others: indicating NIS protein expression in the thyroid diseases and extrathyroidal tissues, studying of the NIS antygenicity in the autoimmune diseases of thyroid, finding the molecular aspects of the difference in the NIS protein activity.	Sodium Iodide	24-37	solute carrier family 5 member 5	Homo sapiens	172-175
18205108-6	2007	Additionally, latest explorations indicate at an innovative destination of the studies concerning the sodium iodide symporter that is the gene therapy with the use of gene NIS transfer.	Sodium Iodide	102-115	solute carrier family 5 member 5	Homo sapiens	172-175
17646169-8	2007	Furthermore, conformational changes induced by the two enantiomers (monitored by sodium iodide accessibility of MRP1 tryptophan residues) were quite different, correlating with their distinct effects.	Sodium Iodide	81-94	ATP binding cassette subfamily C member 1	Homo sapiens	112-116
17698909-1	2007	CONTEXT: We reported recently the induction of iodide accumulation in prostate cancer cells (LNCaP) by prostate-specific antigen promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)iodine ((131)I).	Sodium Iodide	147-160	solute carrier family 5 member 5	Homo sapiens	172-175
17891230-3	2007	However, the studies related to the mechanisms of iodide transport were only possible after the cloning of the gene that encodes the sodium/iodide symporter (NIS).	Sodium Iodide	133-146	solute carrier family 5 member 5	Homo sapiens	158-161
17515401-0	2007	Radioiodide imaging and radiovirotherapy of multiple myeloma using VSV(Delta51)-NIS, an attenuated vesicular stomatitis virus encoding the sodium iodide symporter gene.	Sodium Iodide	139-152	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	80-83
17515401-2	2007	Here, we generated a novel recombinant vesicular stomatitis virus [VSV(Delta51)-NIS] that has a deletion of methionine 51 in the matrix protein and expresses the human sodium iodide symporter (NIS) gene.	Sodium Iodide	168-181	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	80-83
17515401-2	2007	Here, we generated a novel recombinant vesicular stomatitis virus [VSV(Delta51)-NIS] that has a deletion of methionine 51 in the matrix protein and expresses the human sodium iodide symporter (NIS) gene.	Sodium Iodide	168-181	solute carrier family 5 member 5	Homo sapiens	193-196
17565743-0	2007	Human sodium iodide symporter gene adjunctive radiotherapy to enhance the preventive effect of hMUC1 DNA vaccine.	Sodium Iodide	6-19	mucin 1, cell surface associated	Homo sapiens	95-100
17900224-8	2007	This increase after Treg depletion can also be observed in NaI-induced thyroiditis in DR3(+) mice, a means to study a major environmental factor in thyroid autoimmunity.	Sodium Iodide	59-62	tumor necrosis factor receptor superfamily, member 25	Mus musculus	86-89
17696829-1	2007	OBJECTIVE: Nonfunctioning thyroid nodules (NFTNs) display a diminished iodide-concentrating ability, owing to defective expression and cell membrane targeting of the sodium-iodide symporter (NIS).	Sodium Iodide	166-179	solute carrier family 5 member 5	Homo sapiens	191-194
17611400-1	2007	To establish stable and long-term gene expression in vitro and in vivo, we developed a lentiviral vector system carrying sodium iodide symporter (hNIS) gene under UbC promoter, and transfected this into a colon cancer cell line.	Sodium Iodide	121-134	solute carrier family 5 member 5	Homo sapiens	146-150
17639055-0	2007	MEK signaling modulates sodium iodide symporter at multiple levels and in a paradoxical manner.	Sodium Iodide	24-37	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
17297475-0	2007	PTTG and PBF repress the human sodium iodide symporter.	Sodium Iodide	31-44	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	0-4
17297475-0	2007	PTTG and PBF repress the human sodium iodide symporter.	Sodium Iodide	31-44	PTTG1 interacting protein	Homo sapiens	9-12
17297475-4	2007	We now show that PTTG and its binding factor PBF repress expression of sodium iodide symporter (NIS) messenger RNA (mRNA), and inhibit iodide uptake.	Sodium Iodide	71-84	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	17-21
17297475-4	2007	We now show that PTTG and its binding factor PBF repress expression of sodium iodide symporter (NIS) messenger RNA (mRNA), and inhibit iodide uptake.	Sodium Iodide	71-84	PTTG1 interacting protein	Homo sapiens	45-48
17302906-0	2007	Depletion of CD4+CD25+ regulatory T cells exacerbates sodium iodide-induced experimental autoimmune thyroiditis in human leucocyte antigen DR3 (DRB1*0301) transgenic class II-knock-out non-obese diabetic mice.	Sodium Iodide	54-67	CD4 antigen	Mus musculus	13-16
17209001-1	2007	In the myocardium, the Na(+)/H(+) exchanger isoform-1 (NHE1) activity is detrimental during ischemia-reperfusion (I/R) injury, causing increased intracellular Na(+) (Na(i)(+)) accumulation that results in subsequent Ca(2+) overload.	Sodium Iodide	166-174	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	23-53
17209001-1	2007	In the myocardium, the Na(+)/H(+) exchanger isoform-1 (NHE1) activity is detrimental during ischemia-reperfusion (I/R) injury, causing increased intracellular Na(+) (Na(i)(+)) accumulation that results in subsequent Ca(2+) overload.	Sodium Iodide	166-174	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	55-59
17430051-4	2007	Molecular dynamics simulations were also carried out to compare the concentrations of NaCl, NaBr, and NaI at the H2O-vapor and H2O-CCl4 interfaces.	Sodium Iodide	102-105	C-C motif chemokine ligand 4	Homo sapiens	131-135
17408358-2	2007	We determined the dosimetric characteristics of our reporter gene system when coupled with intravenous administration of radioactive sodium pertechnetate (Na(99m) TcO(4)) and determined the feasibility of using human sodium iodide symporter (hNIS) as a reporter gene to study the dynamics of adenoviral transgene expression in a large animal tumor.	Sodium Iodide	217-230	solute carrier family 5 member 5	Homo sapiens	242-246
17302906-0	2007	Depletion of CD4+CD25+ regulatory T cells exacerbates sodium iodide-induced experimental autoimmune thyroiditis in human leucocyte antigen DR3 (DRB1*0301) transgenic class II-knock-out non-obese diabetic mice.	Sodium Iodide	54-67	dopamine receptor binding 1	Mus musculus	144-148
17912014-0	2007	In vivo radioiodide imaging and treatment of pancreatic cancer xenografts after MUC1 promoter-driven expression of the human sodium-iodide symporter.	Sodium Iodide	125-138	mucin 1, cell surface associated	Homo sapiens	80-84
17332617-1	2007	UNLABELLED: Increased expression of the sodium iodide symporter (NIS) is required for effective radioiodine treatment and reporter gene imaging of breast cancer.	Sodium Iodide	40-53	solute carrier family 5 member 5	Homo sapiens	65-68
17912014-2	2007	The aim of this study was to create a construct containing sodium-iodide symporter (NIS) under the control of the 0.8-kb MUC1 promoter to infect pancreatic cancer cells both in vitro and in vivo, to investigate the potential for radioiodide imaging and ablation of this disease.	Sodium Iodide	59-72	solute carrier family 5 member 5	Homo sapiens	84-87
17912014-2	2007	The aim of this study was to create a construct containing sodium-iodide symporter (NIS) under the control of the 0.8-kb MUC1 promoter to infect pancreatic cancer cells both in vitro and in vivo, to investigate the potential for radioiodide imaging and ablation of this disease.	Sodium Iodide	59-72	mucin 1, cell surface associated	Homo sapiens	121-125
16854221-9	2006	Effects of HEX expression on Sodium Iodide Symporter (NIS) gene promoter activity was investigated by HeLa cell transfection.	Sodium Iodide	29-42	hematopoietically expressed homeobox	Homo sapiens	11-14
17340569-3	2007	FAB mass spectra of these compounds produced abundant sodium-adducted molecules [M+Na]+ from a mixture of 3-nitrobenzyl alcohol and sodium iodide.	Sodium Iodide	132-145	FA complementation group B	Homo sapiens	0-3
17133484-3	2006	We evaluated recombinant MV-Edm expressing carcinoembryonic antigen (CEA) or the human sodium iodide symporter (hNIS) for oncolytic potential in hepatocellular carcinoma (HCC) and efficiency in tracking viruses in vivo by noninvasive monitoring.	Sodium Iodide	87-100	solute carrier family 5 member 5	Homo sapiens	112-116
16890194-4	2006	This protocol applied to human nai ve and synthetic phage display antibody libraries led to the selection, in only two rounds, of individual scFv clones (43 out of 46 tested) specific for non-epithelial carcinoma antigens expressed on SKBR3 cells.	Sodium Iodide	31-34	immunglobulin heavy chain variable region	Homo sapiens	141-145
16613988-7	2006	Furthermore, the expression of the CC-Pax8 chimera in differentiated thyroid cells leads to the down-regulation of the endogenous expression of several differentiation markers such as Tg, sodium/iodide symporter, Foxe1, TTF-1, and thyroid oxidase 2.	Sodium Iodide	188-201	paired box 8	Homo sapiens	38-42
16254036-7	2006	Selective knockdown of BRAF prevented RET/PTC-dependent down-regulation of the sodium iodide symporter, a gene that confers key biological effects of RET/PTC in PTCs.	Sodium Iodide	79-92	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	23-27
16644756-1	2006	UNLABELLED: We investigated the feasibility of radioiodine therapy targeting hepatoma cells (MH3924A) by tissue-specific expression of the human sodium/iodide symporter (hNIS) gene directed by the murine albumin enhancer and promoter (mAlb).	Sodium Iodide	145-158	solute carrier family 5 member 5	Homo sapiens	170-174
16720251-3	2006	Herein, we investigated the feasibility of monitoring human sodium iodide symporter (hNIS) gene expression with 99mTc-pertechnetate in hepatoma cells (MH3924A) following tissue-specific expression.	Sodium Iodide	60-73	solute carrier family 5 member 5	Homo sapiens	85-89
16671765-2	2006	The treatment of [2.1.2.1]MCP with trimethylsilyl chloride and sodium iodide yielded two unexpected calixarene derivatives, cone (hemisphere) and 1,2-alternate types, instead of octahydroxy[2.1.2.1]MCP.	Sodium Iodide	63-76	CD46 molecule	Homo sapiens	26-29
16671765-2	2006	The treatment of [2.1.2.1]MCP with trimethylsilyl chloride and sodium iodide yielded two unexpected calixarene derivatives, cone (hemisphere) and 1,2-alternate types, instead of octahydroxy[2.1.2.1]MCP.	Sodium Iodide	63-76	CD46 molecule	Homo sapiens	198-201
16254036-7	2006	Selective knockdown of BRAF prevented RET/PTC-dependent down-regulation of the sodium iodide symporter, a gene that confers key biological effects of RET/PTC in PTCs.	Sodium Iodide	79-92	ret proto-oncogene	Homo sapiens	154-157
16254036-7	2006	Selective knockdown of BRAF prevented RET/PTC-dependent down-regulation of the sodium iodide symporter, a gene that confers key biological effects of RET/PTC in PTCs.	Sodium Iodide	79-92	ret proto-oncogene	Homo sapiens	38-41
16254036-7	2006	Selective knockdown of BRAF prevented RET/PTC-dependent down-regulation of the sodium iodide symporter, a gene that confers key biological effects of RET/PTC in PTCs.	Sodium Iodide	79-92	ret proto-oncogene	Homo sapiens	42-45
16254036-7	2006	Selective knockdown of BRAF prevented RET/PTC-dependent down-regulation of the sodium iodide symporter, a gene that confers key biological effects of RET/PTC in PTCs.	Sodium Iodide	79-92	ret proto-oncogene	Homo sapiens	150-153
16550618-4	2006	FAB-MS spectra produced a significant abundance of the sodium adducts [M+Na]+ and [M+2Na-H]+ from a mixture of m-NBA and NaI.	Sodium Iodide	121-124	FA complementation group B	Homo sapiens	0-3
16179407-3	2006	In HeLa cells, rat follicular thyroid (FRTL-5) cells, or immortalized human thyroid cells, PAX8-PPARgamma stimulated transcription from PAX8-responsive thyroperoxidase and sodium-iodide symporter promoters in a manner at least comparable with wild-type PAX8.	Sodium Iodide	172-185	paired box 8	Homo sapiens	91-95
16179407-3	2006	In HeLa cells, rat follicular thyroid (FRTL-5) cells, or immortalized human thyroid cells, PAX8-PPARgamma stimulated transcription from PAX8-responsive thyroperoxidase and sodium-iodide symporter promoters in a manner at least comparable with wild-type PAX8.	Sodium Iodide	172-185	peroxisome proliferator activated receptor gamma	Homo sapiens	96-105
16671463-7	2006	Genetic ablation of NHE1 and HOE 642 treatment reduced the rise of Na(i)+ by approximately 40% to 50% and abolished the OGD/REOX-mediated Ca2+ accumulation.	Sodium Iodide	67-73	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	20-24
15785238-6	2005	Vectors expressing rat LAP and LIP were constructed to study the effect of C/EBP-beta isoforms on the activity of the sodium iodide symporter (NIS) promoter in PCCL3 cells.	Sodium Iodide	118-131	CCAAT/enhancer binding protein beta	Rattus norvegicus	75-85
15988610-2	2005	The aim of this study was to compare the human sodium iodide symporter gene (hNIS) with the herpes simplex virus type 1 thymidine kinase gene (HSV1-tk) as the reporter gene in non-invasive imaging of cardiac transgene expression with positron emission tomography (PET).	Sodium Iodide	47-60	solute carrier family 5 member 5	Homo sapiens	77-81
16018555-3	2005	C2C12 myoblasts were first transfected with a plasmid containing the human sodium iodide symporter (hNIS) gene.	Sodium Iodide	75-88	solute carrier family 5 member 5	Homo sapiens	100-104
16259567-1	2005	We have demonstrated that the rat sodium iodide symporter (rNIS) and 131I can effectively induce growth arrest of human prostate tumor xenografts [Mitrofanova, E., Unfer, R., Vahanian, N., Daniels, W., Roberson, E., Seregina, T., Seth, P., and Link, C. (2004).	Sodium Iodide	34-47	solute carrier family 5 member 5	Rattus norvegicus	59-63
16259567-2	2005	Rat sodium iodide symporter (rNIS) for radioiodide therapy of cancer.	Sodium Iodide	4-17	solute carrier family 5 member 5	Rattus norvegicus	29-33
16203246-7	2005	NaI also significantly altered liver weights and UDPGT activity but did not affect thyroid hormone levels or thyroid pathology.	Sodium Iodide	0-3	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	49-54
15746050-0	2005	In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter.	Sodium Iodide	106-119	mucin 1, cell surface associated	Homo sapiens	76-80
15746050-1	2005	PURPOSE: Expression of the sodium iodide symporter (NIS) in the thyroid gland provides for effective imaging and treatment of thyroid cancer using radiolabeled iodide.	Sodium Iodide	27-40	solute carrier family 5 member 5	Homo sapiens	52-55
15754731-1	2004	The functional role of the sodium iodide symporter (NIS) in extrathyroidal tissues was investigated by examining its mRNA and protein expression, together with the evidence of radioiodine (131)I uptake in 302 patients who underwent (131)I total body scanning, following the administration of high doses of (131)I for a papillary or follicular thyroid carcinoma.	Sodium Iodide	27-40	solute carrier family 5 member 5	Homo sapiens	52-55
15671536-0	2005	Visualization of endogenous p53-mediated transcription in vivo using sodium iodide symporter.	Sodium Iodide	69-82	tumor protein p53	Homo sapiens	28-31
15671536-1	2005	PURPOSE: To develop a gamma camera imaging method for the determination of endogenous gene expression, we evaluated the expression of endogenous p53 gene using human sodium iodide symporter (hNIS) gene as reporter.	Sodium Iodide	166-179	solute carrier family 5 member 5	Homo sapiens	191-195
15501976-2	2004	Adenovirus-mediated delivery of the sodium iodide symporter (NIS) gene to cancer cells is a powerful technique to concentrate lethal radiation in tumor cells and eradicate tumors with increased therapeutic index.	Sodium Iodide	36-49	solute carrier family 5 member 5	Homo sapiens	61-64
15504362-2	2004	Previously, we have shown that NCX(IF) can completely inhibit either the forward (Na(i)-dependent Ca-uptake) or reverse (Na(o)-dependent Ca-release) mode of Na/Ca exchange as well as its partial reaction, the Ca/Ca exchange.	Sodium Iodide	82-87	T cell leukemia homeobox 2	Homo sapiens	31-34
15671766-1	2004	To evaluate the feasibility of radionuclide gene therapy, we investigated the effect of sodium iodide symporter (NIS) gene transfection on the uptake of some beta- and gamma-emitters in human anaplastic thyroid cancer.	Sodium Iodide	88-101	solute carrier family 5 member 5	Homo sapiens	113-116
15118314-2	2004	After a single administration of (125)I-labeled LF, radioactive bands were detected in autoradioluminograms of the portal blood, but similar bands were also observed after the administration of [(125)I]NaI.	Sodium Iodide	202-205	lactotransferrin	Rattus norvegicus	48-50
15472226-0	2004	Signaling through 3",5"-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer.	Sodium Iodide	93-106	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	59-84
15256462-2	2004	Promoter fragments from either the RNA [human telomerase RNA (hTR)] or the catalytic components [human telomerase reverse transcriptase (hTERT)] of the telomerase genes were used to drive the expression of the sodium iodide symporter PET reporter gene in recombinant adenoviruses.	Sodium Iodide	210-223	telomerase RNA component	Homo sapiens	62-65
15256462-2	2004	Promoter fragments from either the RNA [human telomerase RNA (hTR)] or the catalytic components [human telomerase reverse transcriptase (hTERT)] of the telomerase genes were used to drive the expression of the sodium iodide symporter PET reporter gene in recombinant adenoviruses.	Sodium Iodide	210-223	telomerase reverse transcriptase	Homo sapiens	103-135
15256462-2	2004	Promoter fragments from either the RNA [human telomerase RNA (hTR)] or the catalytic components [human telomerase reverse transcriptase (hTERT)] of the telomerase genes were used to drive the expression of the sodium iodide symporter PET reporter gene in recombinant adenoviruses.	Sodium Iodide	210-223	telomerase reverse transcriptase	Homo sapiens	137-142
15212643-1	2004	OBJECTIVE: The sodium-iodide (Na(+)/I(-)) symporter (NIS) is known to be overexpressed in toxic adenomas and in about half of benign solitary nonfunctioning adenomas of the thyroid.	Sodium Iodide	15-28	solute carrier family 5 member 5	Homo sapiens	30-51
15212643-1	2004	OBJECTIVE: The sodium-iodide (Na(+)/I(-)) symporter (NIS) is known to be overexpressed in toxic adenomas and in about half of benign solitary nonfunctioning adenomas of the thyroid.	Sodium Iodide	15-28	solute carrier family 5 member 5	Homo sapiens	53-56
14976143-8	2004	In an attempt to determine the mechanism by which these gene expressions occurred, we detected the inhibition of protein synthesis by cycloheximide, which up-regulated the expression of thyroperoxidase and thyroglobulin mRNA in HDACI-treated cells and down-regulated that of sodium/iodide symporter mRNA.	Sodium Iodide	275-288	thyroid peroxidase	Homo sapiens	186-201
14976143-8	2004	In an attempt to determine the mechanism by which these gene expressions occurred, we detected the inhibition of protein synthesis by cycloheximide, which up-regulated the expression of thyroperoxidase and thyroglobulin mRNA in HDACI-treated cells and down-regulated that of sodium/iodide symporter mRNA.	Sodium Iodide	275-288	thyroglobulin	Homo sapiens	206-219
15158145-1	2004	OBJECTIVE: Recent work has suggested that Na(+)/Ca(2+) exchange (NCX) and L-type Ca(2+) current (I(Ca)) are located predominantly in the t-tubules of cardiac ventricular myocytes, which therefore represent a microdomain for the regulation of intracellular Na(+) (Na(i)) and Ca(2+) (Ca(i)).	Sodium Iodide	263-268	solute carrier family 8 member A1	Rattus norvegicus	65-68
15136633-1	2004	UNLABELLED: Transfer of the human sodium iodide symporter (hNIS) has been proposed as a new principle of cancer gene therapy.	Sodium Iodide	34-47	solute carrier family 5 member 5	Homo sapiens	59-63
15093193-1	2004	This study describes a quantitative method to measure the magnitude and distribution of gene expression following local delivery of an adenoviral vector containing the human sodium iodide symporter (hNIS) reporter gene into the canine prostate.	Sodium Iodide	174-187	solute carrier family 5 member 5	Homo sapiens	199-203
15001685-1	2004	UNLABELLED: In this study we investigated the feasibility of using radionuclide accumulation mediated by the human sodium iodide symporter (hNIS) gene in conjunction with various imaging modalities as a reporter system to noninvasively monitor the expression of transgenes delivered for gene therapy.	Sodium Iodide	115-128	solute carrier family 5 member 5	Homo sapiens	140-144
14642890-3	2004	CD4+2E3+ T cells show phenotypical and functional characteristics of nai;ve cells.	Sodium Iodide	69-72	CD4 molecule	Homo sapiens	0-3
14978259-2	2004	Previous data from our lab suggested that SEA stabilizes or modulates the transition of NCX1.1 exchangers into a Na+i-dependent (I1) inactive state.	Sodium Iodide	113-117	solute carrier family 8 member A1	Homo sapiens	88-92
14623893-0	2004	The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene.	Sodium Iodide	154-167	paired box 8	Rattus norvegicus	74-78
15068624-2	2004	The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
15068624-2	2004	The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	215-218
15068624-2	2004	The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	215-218
15068624-5	2004	We hypothesized that human sodium iodide symporter (hNIS) transcriptional failure could be caused by primary molecular NIS gene defects and/or methylation of DNA in the NIS promoter.	Sodium Iodide	27-40	solute carrier family 5 member 5	Homo sapiens	52-56
15068624-5	2004	We hypothesized that human sodium iodide symporter (hNIS) transcriptional failure could be caused by primary molecular NIS gene defects and/or methylation of DNA in the NIS promoter.	Sodium Iodide	27-40	solute carrier family 5 member 5	Homo sapiens	53-56
15068624-5	2004	We hypothesized that human sodium iodide symporter (hNIS) transcriptional failure could be caused by primary molecular NIS gene defects and/or methylation of DNA in the NIS promoter.	Sodium Iodide	27-40	solute carrier family 5 member 5	Homo sapiens	119-122
14623893-0	2004	The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene.	Sodium Iodide	154-167	SMAD family member 3	Rattus norvegicus	83-88
15009910-1	2004	The sodium/iodide symporter (NIS) mediates active iodide uptake into thyroid follicular cells and is important for the diagnosis and radioiodide treatment of thyroid cancers.	Sodium Iodide	4-17	solute carrier family 5 member 5	Rattus norvegicus	29-32
14741568-1	2004	We have evaluated the feasibility of human sodium iodide symporter (hNIS) as a reporter gene in vitro and in vivo.	Sodium Iodide	43-56	solute carrier family 5 member 5	Homo sapiens	68-72
15062578-1	2003	This study shows that organification of radioiodide into proteins of thyroid cancer cells exogenously co-expressing the thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS) is independent of NIS function.	Sodium Iodide	153-166	solute carrier family 5 member 5	Homo sapiens	178-181
14629142-0	2003	Regio- and stereoselective C-2 and C-3 cleavage of 2-(1-aminoalkyl)aziridines with alcohols, carboxylic acids, and sodium iodide.	Sodium Iodide	115-128	complement C3	Homo sapiens	35-38
14629142-0	2003	Regio- and stereoselective C-2 and C-3 cleavage of 2-(1-aminoalkyl)aziridines with alcohols, carboxylic acids, and sodium iodide.	Sodium Iodide	115-128	complement C2	Homo sapiens	27-30
14870777-1	2003	The sodium iodide symporter (NIS) is a plasma basolateral membrane protein that actively transports iodide to the thyroid follicular cells as the first step of thyroid hormone biosynthesis.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
14633711-0	2003	Probasin promoter (ARR(2)PB)-driven, prostate-specific expression of the human sodium iodide symporter (h-NIS) for targeted radioiodine therapy of prostate cancer.	Sodium Iodide	79-92	solute carrier family 5 member 5	Homo sapiens	106-109
14599843-8	2003	Primed T cells of IRBP-/- mice transferred an exacerbated form of EAU to nai;ve wild type recipients.	Sodium Iodide	73-76	retinol binding protein 3, interstitial	Mus musculus	18-22
12946325-1	2003	With the goal of optimizing adenovirus-mediated suicide gene therapy for prostate cancer, we have developed a method based on the human sodium iodide symporter (hNIS) that allows for noninvasive monitoring of adenoviral vectors and quantification of gene expression magnitude and volume within the prostate.	Sodium Iodide	136-149	solute carrier family 5 member 5	Homo sapiens	161-165
12946862-7	2003	Furthermore, we demonstrated that Th2 immune responses were elicited by these DCs with high expression of CD80, even to nai;ve T cells from non-treated mice.	Sodium Iodide	120-123	heart and neural crest derivatives expressed 2	Mus musculus	34-37
12946862-7	2003	Furthermore, we demonstrated that Th2 immune responses were elicited by these DCs with high expression of CD80, even to nai;ve T cells from non-treated mice.	Sodium Iodide	120-123	CD80 antigen	Mus musculus	106-110
14510914-2	2003	When present the defect is also found in the salivary glands and gastric mucosa and it has been shown to arise from abnormalities of the sodium/iodide symporter (NIS).	Sodium Iodide	137-150	solute carrier family 5 member 5	Homo sapiens	162-165
14643304-1	2003	Increasing evidence suggests that B7/CD28 interactions are important in clonal expansion and effector function of nai;ve CD4(+) T cells, whereas ICOS/GL50 interactions may optimize the responses of recently activated T(H) cells.	Sodium Iodide	114-117	CD28 antigen	Mus musculus	37-41
14572798-5	2003	M50354 decreased early endogenous IL-4 production in the nai;ve Th cell priming culture without affecting interferon-gamma production and proliferation.	Sodium Iodide	57-60	interleukin 4	Mus musculus	34-38
12941836-2	2003	To enhance tumor apoptosis, we transduced non-small cell lung cancer cells with retroviral vectors containing the sodium iodide symporter (NIS) and thyroperoxidase (TPO) genes.	Sodium Iodide	114-127	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	139-142
12865321-1	2003	We reported recently the induction of androgen-dependent iodide uptake activity in the human prostatic adenocarcinoma cell line LNCaP using a prostate-specific antigen (PSA) promoter-directed expression of the sodium iodide symporter (NIS) gene.	Sodium Iodide	210-223	kallikrein related peptidase 3	Homo sapiens	142-173
12829194-2	2003	Nai;ve CD4+ T cells differentiate into interferon-gamma (IFN-gamma) producing Th1 effector cells when stimulated by interleukin-18 (IL-18) and IL-12.	Sodium Iodide	0-3	interferon gamma	Mus musculus	39-55
12829194-2	2003	Nai;ve CD4+ T cells differentiate into interferon-gamma (IFN-gamma) producing Th1 effector cells when stimulated by interleukin-18 (IL-18) and IL-12.	Sodium Iodide	0-3	interferon gamma	Mus musculus	57-66
12829194-2	2003	Nai;ve CD4+ T cells differentiate into interferon-gamma (IFN-gamma) producing Th1 effector cells when stimulated by interleukin-18 (IL-18) and IL-12.	Sodium Iodide	0-3	interleukin 18	Mus musculus	116-130
12829194-2	2003	Nai;ve CD4+ T cells differentiate into interferon-gamma (IFN-gamma) producing Th1 effector cells when stimulated by interleukin-18 (IL-18) and IL-12.	Sodium Iodide	0-3	interleukin 18	Mus musculus	132-137
12894520-1	2003	The sodium iodide symporter (NIS) is a plasma membrane protein that mediates active uptake of inorganic iodide from plasma into thyroid cells.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
12792733-1	2003	We evaluated the potential of radioiodide therapy in human sodium iodide symporter (hNIS)-defective thyroid cancer cells via exogenous hNIS expression.	Sodium Iodide	59-72	solute carrier family 5 member 5	Homo sapiens	84-88
12914397-2	2003	The sodium iodide symporter NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyrioidal tissues, in particular lactating mammary gland.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	28-31
12704416-1	2003	Transfer of the sodium iodide symporter (hNIS) has been proposed as a new principle of cancer gene therapy.	Sodium Iodide	16-29	solute carrier family 5 member 5	Homo sapiens	41-45
12866814-3	2003	In this prospective study, we report the results of betaAPP immunohistochemistry on the brain and spinal cord in 28 pediatric cases of NAI.	Sodium Iodide	135-138	amyloid beta precursor protein	Homo sapiens	52-59
12576236-8	2003	The role of elevated CCL19 and CCL21 in MS could be retention of mature dendritic cells (DC) in the CNS, recruitment of nai;ve T cells and activated B cells, as well as de novo formation of secondary lymphoid structures in MS plaques.	Sodium Iodide	120-123	C-C motif chemokine ligand 19	Homo sapiens	21-26
12650878-7	2003	NHE inhibition (amiloride 1 mM) in T3 hearts lead to: (1) delayed and lower Na+i accumulation by 35+/-5%; (2) faster and greater acidification (pH(i) 6.45+/-0.15, P<0.05); (3) delayed ATP degradation; and (4) improved heart function during recovery.	Sodium Iodide	76-80	solute carrier family 9 member C1	Homo sapiens	0-3
12798307-4	2003	In addition, these are the first studies to demonstrate that the combined use of a vector driving the expression of OX40L with three other costimulatory molecules (B7-1, ICAM-1, and LFA-3) both enhances initial activation and then further potentiates sustained activation of nai;ve and effector T cells.	Sodium Iodide	275-278	TNF superfamily member 4	Homo sapiens	116-121
12798307-4	2003	In addition, these are the first studies to demonstrate that the combined use of a vector driving the expression of OX40L with three other costimulatory molecules (B7-1, ICAM-1, and LFA-3) both enhances initial activation and then further potentiates sustained activation of nai;ve and effector T cells.	Sodium Iodide	275-278	CD80 molecule	Homo sapiens	164-168
12798307-4	2003	In addition, these are the first studies to demonstrate that the combined use of a vector driving the expression of OX40L with three other costimulatory molecules (B7-1, ICAM-1, and LFA-3) both enhances initial activation and then further potentiates sustained activation of nai;ve and effector T cells.	Sodium Iodide	275-278	CD58 molecule	Homo sapiens	182-187
12788303-6	2003	Unlike IL-18, IL-18BP mRNA was up-regulated dramatically by approximately 12-fold above nai;ve levels, peaking 3 h after LPS injection.	Sodium Iodide	88-91	interleukin 18 binding protein	Rattus norvegicus	14-21
12747954-6	2003	Interesting species-specific nai;ve versus memory T cell subset differences emerged with regard to susceptibility to Fas-mediated apoptosis and costimulator:FasL opposition.	Sodium Iodide	29-32	Fas ligand	Homo sapiens	157-161
12576236-8	2003	The role of elevated CCL19 and CCL21 in MS could be retention of mature dendritic cells (DC) in the CNS, recruitment of nai;ve T cells and activated B cells, as well as de novo formation of secondary lymphoid structures in MS plaques.	Sodium Iodide	120-123	C-C motif chemokine ligand 21	Homo sapiens	31-36
12490370-6	2003	Production of IFN-gamma and IL-6 was increased, for formulated as compared to free antigen, in microcultures from both nai;ve and pre-immunised animals.	Sodium Iodide	119-122	interferon gamma	Mus musculus	14-23
12490370-6	2003	Production of IFN-gamma and IL-6 was increased, for formulated as compared to free antigen, in microcultures from both nai;ve and pre-immunised animals.	Sodium Iodide	119-122	interleukin 6	Mus musculus	28-32
12705478-1	2003	The function of the sodium iodide symporter (Na(+)/I(-), (NIS), a membrane protein that mediates iodide transport into cells, is the best described in the thyroid cells.	Sodium Iodide	20-33	solute carrier family 5 member 5	Homo sapiens	58-61
12477251-1	2002	Radioiodide uptake (RAIU) in thyroid follicular epithelial cells, mediated by a plasma membrane transporter, sodium iodide symporter (NIS), provides a first step mechanism for thyroid cancer detection by radioiodide injection and effective radioiodide treatment for patients with invasive, recurrent, and/or metastatic thyroid cancers after total thyroidectomy.	Sodium Iodide	109-122	solute carrier family 5 member 5	Homo sapiens	134-137
12480328-9	2002	A less intense Th1 pattern was also found from HS stimulated nai;ve splenic cells.	Sodium Iodide	61-64	negative elongation factor complex member C/D, Th1l	Mus musculus	15-18
12458023-5	2002	RESULTS: GnRH fiber counts were significantly lower in KA than saline and nai;ve animals ipsilaterally but not contralaterally.	Sodium Iodide	74-77	gonadotropin releasing hormone 1	Rattus norvegicus	9-13
12431386-5	2002	IL-6 activates transcription mediated by nuclear factor of activated T cells (NFAT) leading to production of IL-4 by nai;ve CD4(+) T cells and their differentiation into effector Th2 cells.	Sodium Iodide	117-120	interleukin 6	Homo sapiens	0-4
12473240-6	2002	Passive transfer of PLP(180-199)-primed lymph node cells into nai;ve BALB/c mice resulted in EAE (2/2 mice, max score of 4.0).	Sodium Iodide	62-65	proteolipid protein (myelin) 1	Mus musculus	20-23
12485453-5	2002	Thyroid-stimulating hormone receptor expressing cells also expressed the sodium iodide symporter and thyroglobulin genes.	Sodium Iodide	73-86	thyroid stimulating hormone receptor	Homo sapiens	0-36
12431386-5	2002	IL-6 activates transcription mediated by nuclear factor of activated T cells (NFAT) leading to production of IL-4 by nai;ve CD4(+) T cells and their differentiation into effector Th2 cells.	Sodium Iodide	117-120	interleukin 4	Homo sapiens	109-113
12432093-4	2002	The results reported here show that in the absence of either TSH or a functional TSHR, the thyroid gland develops to a normal size, whereas the expression of thyroperoxidase and the sodium/iodide symporter are reduced greatly.	Sodium Iodide	182-195	thyroid stimulating hormone receptor	Mus musculus	81-85
12432093-6	2002	These data suggest that the major role of the TSH/TSHR pathway is in controlling genes involved in iodide metabolism such as sodium/iodide symporter and thyroperoxidase.	Sodium Iodide	125-138	thyroid stimulating hormone receptor	Mus musculus	50-54
12432094-9	2002	Hence, by using the TSHR-KO mouse, we provided in vivo evidence, demonstrating that TSHR expression was required for expression of sodium-iodide symporter but was not required for thyroglobulin expression, suggesting that the thyroid hormone synthetic pathway of the mouse could be dissociated into TSHR-dependent and -independent steps.	Sodium Iodide	131-144	thyroid stimulating hormone receptor	Mus musculus	20-24
12234621-3	2002	cAMP inhibited CD3-induced CD40L in both nai;ve and memory subsets, although greater inhibition was observed in memory cells.	Sodium Iodide	41-44	cathelicidin antimicrobial peptide	Homo sapiens	0-4
12432094-9	2002	Hence, by using the TSHR-KO mouse, we provided in vivo evidence, demonstrating that TSHR expression was required for expression of sodium-iodide symporter but was not required for thyroglobulin expression, suggesting that the thyroid hormone synthetic pathway of the mouse could be dissociated into TSHR-dependent and -independent steps.	Sodium Iodide	131-144	thyroid stimulating hormone receptor	Mus musculus	84-88
12432094-9	2002	Hence, by using the TSHR-KO mouse, we provided in vivo evidence, demonstrating that TSHR expression was required for expression of sodium-iodide symporter but was not required for thyroglobulin expression, suggesting that the thyroid hormone synthetic pathway of the mouse could be dissociated into TSHR-dependent and -independent steps.	Sodium Iodide	131-144	thyroid stimulating hormone receptor	Mus musculus	84-88
12390328-1	2002	The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
12435401-2	2002	Here, we demonstrate that antigen-specific CD4(+) nai;ve T cells primed with either altered peptide ligands (APLs) or a minimal concentration of antigen peptide become anergic without observable cell divisions.	Sodium Iodide	50-53	CD4 molecule	Homo sapiens	43-46
12435401-4	2002	Productively stimulated nai;ve T cells expressed IL-2 to differentiate into T helper 1 (Th1) cells, secreting interferon-gamma (IFN-gamma) upon secondary antigen stimulation; T cells primed with an APL did not secrete either interleukin-4 (IL-4) or IFN-gamma, but expressed TGF-beta1 and Tob, a member of the anti-proliferative gene family.	Sodium Iodide	24-27	interleukin 2	Homo sapiens	49-53
12435401-4	2002	Productively stimulated nai;ve T cells expressed IL-2 to differentiate into T helper 1 (Th1) cells, secreting interferon-gamma (IFN-gamma) upon secondary antigen stimulation; T cells primed with an APL did not secrete either interleukin-4 (IL-4) or IFN-gamma, but expressed TGF-beta1 and Tob, a member of the anti-proliferative gene family.	Sodium Iodide	24-27	interferon gamma	Homo sapiens	128-137
12435401-6	2002	These results suggest that partial antigen stimulation in the periphery can induce nai;ve CD4(+)T cell unresponsiveness.	Sodium Iodide	83-86	CD4 molecule	Homo sapiens	90-93
12234621-3	2002	cAMP inhibited CD3-induced CD40L in both nai;ve and memory subsets, although greater inhibition was observed in memory cells.	Sodium Iodide	41-44	CD40 ligand	Homo sapiens	27-32
12234621-5	2002	In primed T cells, cAMP increased CD40L on nai;ve cells but inhibited expression on memory cells.	Sodium Iodide	43-46	cathelicidin antimicrobial peptide	Homo sapiens	19-23
12234621-5	2002	In primed T cells, cAMP increased CD40L on nai;ve cells but inhibited expression on memory cells.	Sodium Iodide	43-46	CD40 ligand	Homo sapiens	34-39
12234621-6	2002	Differential cAMP effects appear interrelated to calcium signaling since the level of CD40L induced by calcium ionophore was increased by cAMP in both cell subsets, although nai;ve cells were more calcium responsive.	Sodium Iodide	174-177	cathelicidin antimicrobial peptide	Homo sapiens	13-17
12473265-4	2002	Using nai;ve T cells from TCR transgenic mice, we found that compared to the antigenic peptide from pigeon cytochrome c, the SAG staphylococcal enterotoxin A very efficiently (100-2000-fold more sensitive on a weight basis) induced tyrosine kinase activity, intracellular calcium increase, and interferon (IFN)gamma production.	Sodium Iodide	6-9	S-antigen, retina and pineal gland (arrestin)	Mus musculus	125-128
12381453-0	2002	Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells.	Sodium Iodide	0-13	solute carrier family 5 member 5	Homo sapiens	25-28
12381453-0	2002	Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells.	Sodium Iodide	0-13	solute carrier family 5 member 5	Homo sapiens	76-79
12381453-1	2002	The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types.	Sodium Iodide	31-44	solute carrier family 5 member 5	Homo sapiens	56-59
12161518-2	2002	These were the only cases reported to date who received long-term iodide treatment over 10 yr. We examined the sodium/iodide symporter (NIS) gene of these patients.	Sodium Iodide	111-124	solute carrier family 5 member 5	Homo sapiens	136-139
12217340-7	2002	Moreover, in combination with a subthreshold stimulus with anti-IgM, enolase augmented the expression of CD69 and B7.2 in nai;ve B cells from normal mice.	Sodium Iodide	122-125	CD69 antigen	Mus musculus	105-109
12199711-5	2002	TOP was activated by all assayed salts in the range 0.05-0.2 m for NaCl, KCl, NH4Cl and NaI, and 0.025-0.1 m for Na2SO4.	Sodium Iodide	88-91	thimet oligopeptidase 1	Homo sapiens	0-3
12199711-6	2002	Concentration higher than 0.2 N NH4Cl and NaI reduced TOP activity, while 0.5 N or higher concentration of NaCl, KCl and Na2SO4 increased TOP activity.	Sodium Iodide	42-45	thimet oligopeptidase 1	Homo sapiens	54-57
12225868-7	2002	On the other hand, morphine alone (50 mg/kg) caused only a weak c-fos expression in nai;ve animals despite of the rather high dose.	Sodium Iodide	84-87	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-69
12367556-4	2002	Functionally, NOD DCs exhibited higher expression of CD80/86 and IL-12 production during stimulation of nai;ve T cells, even in comparison to C57BL/6 DCs, the prototype strain for vigorous, Th1-biased immunity.	Sodium Iodide	104-107	CD80 antigen	Mus musculus	53-57
12034050-1	2002	We describe the cloning and characterization of a human sodium iodide (NIS) upstream enhancer (NUE).	Sodium Iodide	56-69	solute carrier family 5 member 5	Homo sapiens	71-74
12107249-3	2002	We show here, using COS-7 cells and Chinese hamster ovary cells transfected with expression vectors encoding sodium iodide symporter or human Pendred syndrome gene cDNA and by comparison with studies using rat thyroid FRTL-5 cells, that pendrin is an iodide-specific transporter in mammalian cells and is responsible for iodide efflux in the thyroid.	Sodium Iodide	109-122	solute carrier family 26 member 4	Rattus norvegicus	237-244
12579844-5	2002	Fluorescence quenching experiments with NaI and acrylamide as quenchers showed that the KSVs (the slope of Strm-Volmer equation) of insulin were more similar to that with added liposome, indicating low interaction between insulin with liposome.	Sodium Iodide	40-43	insulin	Homo sapiens	132-139
11578905-1	2001	We investigated a correlation between the expression of human sodium iodide symporter (hNIS) mRNA and the uptake of 99mTc-pertechnetate in 25 breast tumors.	Sodium Iodide	62-75	solute carrier family 5 member 5	Homo sapiens	87-91
11788674-4	2002	A defect in the expression or structure of the sodium iodide symporter (NIS) gene has been hypothesized as a possible cause of the impaired iodide trapping in nonfunctioning thyroid nodules.	Sodium Iodide	47-60	solute carrier family 5 member 5	Homo sapiens	72-75
11889195-2	2002	However, loss of iodide uptake is frequently observed in metastasized thyroid cancer, which may be explained by diminished expression of the human sodium-iodide symporter (hNIS).	Sodium Iodide	147-160	solute carrier family 5 member 5	Homo sapiens	172-176
11701745-1	2001	The ability of thyroid cancers to concentrate radioiodine (RAI) is dependent, in part, upon the expression and functional integrity of the sodium iodide symporter (NIS).	Sodium Iodide	139-152	solute carrier family 5 member 5	Homo sapiens	164-167
11525275-2	2001	We report two such patients and demonstrate that the in vivo 131I uptake by the kidney metastasis is associated with high levels of sodium iodide (Na+/I-) symporter (NIS) expression in the first case.	Sodium Iodide	132-145	solute carrier family 5 member 5	Homo sapiens	147-164
11454552-10	2001	These findings demonstrate that flux via NKCC is increased in type I diabetic hearts and that inhibition with bumetanide attenuates changes in Na(i) and ATP during ischemia and protects against ischemic injury.	Sodium Iodide	143-148	solute carrier family 12 member 1	Homo sapiens	41-45
11571539-0	2001	Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer.	Sodium Iodide	105-118	thyroid peroxidase	Homo sapiens	26-41
11313309-11	2001	CONCLUSIONS: IFN-gamma inhibition of Na+,K+-ATPase activity acutely causes increases in intracellular Na(i) concentration and cell volume, which are distinct signaling events that ultimately result in a leaky and dysfunctional epithelium associated with chronic inflammation.	Sodium Iodide	102-107	interferon gamma	Homo sapiens	13-22
11443211-10	2001	In hypofunctioning adenomas, LNOX immunostaining was highly variable among follicles, whereas sodium/iodide (Na+/I-) symporter immunostaining was decreased.	Sodium Iodide	94-107	solute carrier family 5 member 5	Homo sapiens	109-126
11375795-1	2001	OBJECTIVE: The human sodium iodide symporter (hNIS) is a candidate autoantigen in autoimmune thyroid diseases.	Sodium Iodide	21-34	solute carrier family 5 member 5	Homo sapiens	46-50
11478264-1	2001	The extent of human sodium iodide symporter (hNIS) expression in different kinds of human thyroid cancer tissues and cell lines remains controversial.	Sodium Iodide	20-33	solute carrier family 5 member 5	Homo sapiens	45-49
11396700-3	2001	Now that the molecule that mediates radioiodine uptake, the sodium iodide symporter (NIS), has been cloned and characterized, it may be possible to develop novel strategies to differentially modulate NIS expression and/or activity, enhancing it in target tissues and impeding it in others.	Sodium Iodide	60-73	solute carrier family 5 member 5	Homo sapiens	85-88
11396700-3	2001	Now that the molecule that mediates radioiodine uptake, the sodium iodide symporter (NIS), has been cloned and characterized, it may be possible to develop novel strategies to differentially modulate NIS expression and/or activity, enhancing it in target tissues and impeding it in others.	Sodium Iodide	60-73	solute carrier family 5 member 5	Homo sapiens	200-203
11573143-2	2001	The transport of iodide across the cell membrane is mediated by the sodium iodide symporter (hNIS).	Sodium Iodide	68-81	solute carrier family 5 member 5	Homo sapiens	93-97
11301205-12	2001	Prevention of elevated Nai+ levels is likely to provide neuroprotection by decreasing presynaptic glutamate release and by improving cellular osmoregulation, adenosine triphosphate utilization and Ca2+ clearance.	Sodium Iodide	23-27	carbonic anhydrase 2	Rattus norvegicus	197-200
11137035-3	2001	For example, whereas follicular thyroglobulin suppresses the gene expression and activity of the sodium iodide symporter (NIS), it increases pendrin gene expression.	Sodium Iodide	97-110	thyroglobulin	Homo sapiens	32-45
11090084-6	2000	Cytokine-activated PMNLs expressed functional CCR6, as detected by the binding of sodium iodide I 125-labeled liver and activation-regulated chemokine (LARC) and dose-dependent migration toward LARC.	Sodium Iodide	82-95	C-C motif chemokine receptor 6	Homo sapiens	46-50
11006268-14	2000	Inhibition of the p38-MAPK pathway with SB203580 partially but significantly, attenuates cAMP- and TSH-induced expression of the sodium iodide symporter in FRTL-5 cells.	Sodium Iodide	129-142	mitogen activated protein kinase 14	Rattus norvegicus	18-21
11272095-1	2001	Decrease or loss of the sodium iodide (Na+/I-) symporter (NIS) activity influences the suitability of using radioiodine to detect and treat metastatic thyroid tissues.	Sodium Iodide	24-37	solute carrier family 5 member 5	Homo sapiens	39-56
10959589-1	2000	An SN2 reaction (NaI) of 1,7-di(methanesulfoxyl)heptadien-4-yl methoxy-(2-naphthyl)acetate and a tributyltin hydride reduction of 1,7-diiodo-4-yl methoxy-(2-naphthyl)acetate (2NMA) is crucial for determination of the absolute configuration of secondary alcohols.	Sodium Iodide	17-20	solute carrier family 38 member 5	Homo sapiens	3-6
11134119-1	2000	Several studies suggest that the sodium-iodide symporter (NIS) may represent a major autoantigen in autoimmune diseases of the thyroid.	Sodium Iodide	33-46	solute carrier family 5 member 5	Homo sapiens	58-61
11078986-0	2000	Sodium-iodide symporter (NIS) gene expression in lymph-node metastases of papillary thyroid carcinomas.	Sodium Iodide	0-13	solute carrier family 5 member 5	Homo sapiens	25-28
11128720-0	2000	Reestablishment of in vitro and in vivo iodide uptake by transfection of the human sodium iodide symporter (hNIS) in a hNIS defective human thyroid carcinoma cell line.	Sodium Iodide	83-96	solute carrier family 5 member 5	Homo sapiens	108-112
11128720-0	2000	Reestablishment of in vitro and in vivo iodide uptake by transfection of the human sodium iodide symporter (hNIS) in a hNIS defective human thyroid carcinoma cell line.	Sodium Iodide	83-96	solute carrier family 5 member 5	Homo sapiens	119-123
11128720-2	2000	However, loss of iodide uptake is frequently observed in metastasized thyroid cancer, which may be explained by diminished expression of the human sodium iodide symporter (hNIS).	Sodium Iodide	147-160	solute carrier family 5 member 5	Homo sapiens	172-176
11001757-0	2000	Effect of prolactin on sodium iodide symporter expression in mouse mammary gland explants.	Sodium Iodide	23-36	prolactin	Mus musculus	10-19
11001757-3	2000	In the present studies, we demonstrate via Western blotting techniques that prolactin elevates the quantity of the sodium iodide symporter (NIS) in cultured mouse mammary tissues.	Sodium Iodide	115-128	prolactin	Mus musculus	76-85
11069301-4	2000	We demonstrate that the reintroduction of Pax8 in PCPy cells is sufficient to activate expression of the endogenous genes encoding thyroglobulin, thyroperoxidase, and sodium/iodide symporter.	Sodium Iodide	167-180	paired box 8	Rattus norvegicus	42-46
10890895-1	2000	The sodium/iodide symporter (NIS) stimulates iodide uptake in normal lactating breast, but is not known to be active in nonlactating breast or breast cancer.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
10902780-1	2000	Molecular cloning of the sodium/iodide symporter (NIS) allowed identification of NIS gene mutations in patients with iodide trapping defect.	Sodium Iodide	25-38	solute carrier family 5 member 5	Homo sapiens	50-53
10902780-1	2000	Molecular cloning of the sodium/iodide symporter (NIS) allowed identification of NIS gene mutations in patients with iodide trapping defect.	Sodium Iodide	25-38	solute carrier family 5 member 5	Homo sapiens	81-84
10707050-0	2000	Molecular study of the sodium-iodide symporter (NIS): a new field in thyroidology.	Sodium Iodide	23-36	solute carrier family 5 member 5	Rattus norvegicus	48-51
10843191-1	2000	The sodium iodide symporter (NIS) is a novel autoantigen in autoimmune thyroid disease (ATD).	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
10588823-1	1999	The recent cloning of the thyroidal protein that is responsible for iodide transport, the sodium iodide symporter (hNIS), has made possible studies designed to characterize its structure, function and expression in thyroidal tissues.	Sodium Iodide	90-103	solute carrier family 5 member 5	Homo sapiens	115-119
10718739-13	2000	Repeated low rate depolarizations in Na+i/Na+o solutions induced a use-dependent loss of Kv1.5 channel Na+ conductance, distinct from that caused by C-type inactivation.	Sodium Iodide	37-41	potassium voltage-gated channel subfamily A member 5	Homo sapiens	89-94
10691652-3	2000	The method employed is based on derivatization of S-alk(en)ylcysteine sulfoxides with ethyl chloroformate followed by their reduction with sodium iodide.	Sodium Iodide	139-152	ALK receptor tyrosine kinase	Homo sapiens	52-55
10779135-1	2000	The sodium iodide symporter (NIS) is a plasma membrane protein that is responsible for iodide transport into thyroid cells.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
9589686-3	1998	Recently, cloning and molecular characterization of the human sodium iodide symporter (hNIS) have been reported; however, the patterns of hNIS gene expression in human tissues have remained unidentified.	Sodium Iodide	62-75	solute carrier family 5 member 5	Homo sapiens	87-91
10232600-2	1999	Causing prostate cancer cells to express functionally active sodium iodide symporter (NIS) would enable those cells to concentrate iodide from plasma and might offer the ability to treat prostate cancer with radioiodine.	Sodium Iodide	61-74	solute carrier family 5 member 5	Homo sapiens	86-89
10319949-1	1999	The sodium iodide symporter (NIS) is the plasma membrane protein that mediates active iodide uptake into thyroid follicular cells.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
9876351-1	1998	OBJECTIVE: Iodide uptake by the thyroid gland is mediated by the sodium iodide symporter (NIS).	Sodium Iodide	65-78	solute carrier family 5 member 5	Homo sapiens	90-93
9653173-3	1998	Thyrotropin (TSH), via its receptor (TSHR), increases thyroid hormone levels by up-regulating expression of the sodium iodide symporter (NIS), thyroid peroxidase (TPO), and TG genes.	Sodium Iodide	112-125	thyroid stimulating hormone receptor	Homo sapiens	37-41
10566669-1	1999	The human sodium iodide symporter (hNIS) is an intrinsic transmembrane protein that mediates the active transport of iodide across the basolateral membrane of thyroid follicular cells.	Sodium Iodide	10-23	solute carrier family 5 member 5	Homo sapiens	35-39
10566669-3	1999	After cloning and molecular characterization of the sodium iodide symporter, expression of hNIS messenger ribonucleic acid has been detected in a broad range of extrathyroidal tissues using Northern blot analysis and RT-PCR.	Sodium Iodide	52-65	solute carrier family 5 member 5	Homo sapiens	91-95
10403177-2	1999	This function is mediated through the sodium iodide symporter (NIS), a protein that is located in the basolateral membrane of the thyrocyte.	Sodium Iodide	38-51	solute carrier family 5 member 5	Homo sapiens	63-66
10401666-3	1999	Thyrotropin (TSH), via its receptor (the TSHR), increases thyroid hormone levels by upregulating expression of the sodium iodide symporter (NIS), thyroid peroxidase (TPO), and TG genes.	Sodium Iodide	115-128	thyroid stimulating hormone receptor	Homo sapiens	41-45
10401666-3	1999	Thyrotropin (TSH), via its receptor (the TSHR), increases thyroid hormone levels by upregulating expression of the sodium iodide symporter (NIS), thyroid peroxidase (TPO), and TG genes.	Sodium Iodide	115-128	solute carrier family 5 member 5	Homo sapiens	140-143
10355044-1	1999	Cloning, functional characterisation, and diagnostic proof of the expression of sodium-iodide-symporter (NIS) in the thyroid are essential steps for a better understanding of function and regulation of thyroid hormone synthesis, which is limited by the availability of the trace element iodide.	Sodium Iodide	80-93	solute carrier family 5 member 5	Homo sapiens	105-108
12114713-7	1998	Sequencing of the entire sodium/iodide (Na/I) symporter (NIS) cDNA derived from thyroidal mRNA revealed a homozygous substitution of the normal cytosine in nucleotide 1163 with an adenine, resulting in a stop signal at codon 272.	Sodium Iodide	25-38	solute carrier family 5 member 5	Homo sapiens	40-55
9865544-0	1998	Implications of the molecular characterization of the sodium-iodide symporter (NIS).	Sodium Iodide	54-67	solute carrier family 5 member 5	Homo sapiens	79-82
9565406-14	1998	Our results show that regulatory Ca2+i decreases Na+i-induced inactivation of CALX1.2, whereas it stabilizes the Na+i-induced inactive state of CALX1.1.	Sodium Iodide	113-117	Na/Ca-exchange protein	Drosophila melanogaster	144-151
9865544-1	1998	The recently cloned sodium-iodide symporter (NIS) represents a key molecule for thyroid function by efficiently accumulating iodide from the circulation into the thyrocyte against an electrochemical gradient.	Sodium Iodide	20-33	solute carrier family 5 member 5	Homo sapiens	45-48
9284544-7	1997	The MPO and leukocytes can iodinate BSA using NaI or thyroxine as the source of iodine.	Sodium Iodide	46-49	myeloperoxidase	Rattus norvegicus	4-7
9231811-1	1997	The active iodide uptake of the thyroid gland in humans is mediated by the human sodium iodide symporter (hNIS).	Sodium Iodide	81-94	solute carrier family 5 member 5	Homo sapiens	106-110
8707858-6	1996	In other studies, extracellular ATP (ATPo) produced an increase in Ca2+i and Na+i.	Sodium Iodide	77-81	ATP synthase peripheral stalk subunit OSCP	Rattus norvegicus	37-41
8981993-7	1997	Moreover, osg1-1 mutants producing mannitol were more resistant to killing by oxidants produced by a cell-free H2O2-FeSO4-NaI system than were controls.	Sodium Iodide	122-125	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	10-16
8876626-9	1996	For complex formation using IgG and ovalbumin the presence of NaC1 at concentrations up to 0.6 M led to a progressive increase in the time of onset of phase 2; potencies of inhibition by other sodium halides followed the lyotropic series NaF < NaC1 < NaI.	Sodium Iodide	257-260	nucleus accumbens associated 1	Homo sapiens	62-66
9089442-13	1997	Ba2+ is also much less effective at alleviating Na+i-induced inactivation of NCX1.	Sodium Iodide	48-52	solute carrier family 8 (sodium/calcium exchanger), member 1 S homeolog	Xenopus laevis	77-81
8707858-10	1996	We conclude that, in rat submandibular gland acini, ATPo promotes an increase in Ca2+i and Na+i via a common influx pathway and that, under physiologic conditions, Na+ significantly limits the ATPo-stimulated increase in Ca2+i.	Sodium Iodide	91-95	ATP synthase peripheral stalk subunit OSCP	Rattus norvegicus	52-56
8743531-3	1996	Superfusing with a HEPES solution containing Ang II (1 microM) caused a progressive increase in Nai+.	Sodium Iodide	96-100	angiotensinogen	Rattus norvegicus	45-51
8591892-3	1996	Ang II (10(-6) mol/L) caused a rapid rise in Na+i followed by a progressive increase that peaked at about 10 minutes (from 11 +/- 1.5 to 16 +/- 1.5 mmol/L, P < .001), whereas Ang-(1-7) (10(-6) mol/L) did not affect Na+i significantly (from 11.5 +/- 1.1 to 11.8 +/- 0.07 mmol/L).	Sodium Iodide	45-49	angiotensinogen	Rattus norvegicus	0-6
8591892-3	1996	Ang II (10(-6) mol/L) caused a rapid rise in Na+i followed by a progressive increase that peaked at about 10 minutes (from 11 +/- 1.5 to 16 +/- 1.5 mmol/L, P < .001), whereas Ang-(1-7) (10(-6) mol/L) did not affect Na+i significantly (from 11.5 +/- 1.1 to 11.8 +/- 0.07 mmol/L).	Sodium Iodide	45-49	angiogenin	Rattus norvegicus	0-3
8618875-7	1995	In human THP-1 macrophagic cells, osmotic stimulation with KI, NaI, or NaCl also induced IL-8 production.	Sodium Iodide	63-66	GLI family zinc finger 2	Homo sapiens	9-14
8618875-7	1995	In human THP-1 macrophagic cells, osmotic stimulation with KI, NaI, or NaCl also induced IL-8 production.	Sodium Iodide	63-66	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
8745146-4	1995	Exposure of TFCs to sodium iodide (NaI; 0.1-100 mumol/l) led to an attenuation of the IGF-I content of the cell-conditioned medium.	Sodium Iodide	20-33	insulin like growth factor 1	Homo sapiens	86-91
8745146-4	1995	Exposure of TFCs to sodium iodide (NaI; 0.1-100 mumol/l) led to an attenuation of the IGF-I content of the cell-conditioned medium.	Sodium Iodide	35-38	insulin like growth factor 1	Homo sapiens	86-91
8745146-6	1995	The inhibitory effect of NaI on IGF-I production and [methyl-3H]thymidine incorporation were reversed by the thionamide compound methimazole (MMI; 1 mmol/l), exposure to which also led to significant (P < 0.001) increases above control values.	Sodium Iodide	25-28	insulin like growth factor 1	Homo sapiens	32-37
8257866-7	1993	NaI (100 microM) increased the prepro-ET-1 mRNA level.	Sodium Iodide	0-3	endothelin 1	Homo sapiens	38-42
8251941-4	1993	BDNF was iodinated using a stoichiometric amount of nonradioactive cold NaI to minimize multiple iodinations.	Sodium Iodide	72-75	brain derived neurotrophic factor	Homo sapiens	0-4
8575471-3	1995	Human serum albumin labeled with iodine-131 is used with an externally mounted and collimated NaI(Tl) detector to track the leakage of blood from the isolated perfusion blood circuit into the general systemic vascular space.	Sodium Iodide	94-97	albumin	Homo sapiens	12-19
8014600-2	1994	Northern blotting of RNA extracted from 72-h cultures revealed a 2.5 kb mRNA transcript hybridizing with a cDNA probe for latent TGF-beta 1, the intensity of which was doubled in cells exposed to NaI (10 mumol/l).	Sodium Iodide	196-199	transforming growth factor beta 1	Homo sapiens	129-139
8257866-9	1993	The amount of ir-ET-1 released from the cells was also increased by the NaI treatment and the increase was also attenuated by MMl.	Sodium Iodide	72-75	endothelin 1	Homo sapiens	17-21
1476606-2	1992	RNA extracted from TFCs maintained in the absence of iodide contained a 2.5 kb transcript which hybridized specifically with a cDNA probe for human TGF-beta 1, and which showed an approximate doubling in intensity in cells exposed to 10 mumol NaI/1.	Sodium Iodide	243-246	transforming growth factor beta 1	Homo sapiens	148-158
1799225-3	1991	IGF-II was iodinated at all three tyrosines using lactoperoxidase with a three-fold excess of sodium iodide.	Sodium Iodide	94-107	insulin like growth factor 2	Homo sapiens	0-6
1315258-8	1992	In long term studies of the same experimental conditions, with 10(-6) M NaI added to the culture medium, an increase in radioimmunoassayable T4 and T3 in conditioned cell culture media and cell layer extracts was confirmed for all conditions, with the exception of physiological concentrations of insulin.	Sodium Iodide	72-75	LOC105613195	Ovis aries	297-304
1311767-6	1992	Because the exchanger was active under basal conditions we tested the hypothesis that changes in intracellular Na (Nai) would alter pHi in a predictable way.	Sodium Iodide	115-118	glucose-6-phosphate isomerase	Oryctolagus cuniculus	132-135
1518372-5	1992	Thyroid peroxidase (TPO) activity in the cultured follicles with TSH for 96 h was dose-dependently inhibited by NaI.	Sodium Iodide	112-115	thyroid peroxidase	Homo sapiens	0-18
1518372-5	1992	Thyroid peroxidase (TPO) activity in the cultured follicles with TSH for 96 h was dose-dependently inhibited by NaI.	Sodium Iodide	112-115	thyroid peroxidase	Homo sapiens	20-23
1518372-6	1992	One hundred microM of NaI completely inhibited TSH-induced TPO activity.	Sodium Iodide	22-25	thyroid peroxidase	Homo sapiens	59-62
1518372-9	1992	These data provide direct evidences that thyroid hormone synthesis is regulated by NaI as well as TSH at least in part via regulation of TPO activity and also that both EGF and PMA are inhibitory on thyroid hormone formation.	Sodium Iodide	83-86	thyroid peroxidase	Homo sapiens	137-140
1745008-10	1991	Within 30 minutes of VP (20 mU/ml) exposure, however, the Nai peak increased 2.47 times above pretreatment baseline (N = 16, P less than 0.001).	Sodium Iodide	58-61	arginine vasopressin	Homo sapiens	21-23
1745008-11	1991	The Nai signal returned toward baseline values with removal of VP from the serosal bath but only after approximately 90 minutes.	Sodium Iodide	4-7	arginine vasopressin	Homo sapiens	63-65
1868067-5	1991	Comparative steady-state measurements carried out in the presence of NaCl, NaBr, NaI, KCl, and MgCl2 show that human alpha-thrombin is capable of discriminating among different cations and anions.	Sodium Iodide	81-84	coagulation factor II, thrombin	Homo sapiens	123-131
33816784-1	2021	Encoding the sodium iodide symporter (NIS) by an adenovirus (Ad) is a promising strategy to facilitate non-invasive imaging and radiotherapy of pancreatic cancer.	Sodium Iodide	13-26	solute carrier family 5 member 5	Homo sapiens	38-41
2090100-3	1990	Purified porcine thyroglobulin or bovine serum albumin as acceptor protein was iodinated with [125I]NaI and H2O2 by purified porcine TPO.	Sodium Iodide	100-103	thyroid peroxidase	Homo sapiens	133-136
1880476-4	1991	Exposure of porcine thyroid follicular cells in subconfluent monolayer culture to TGF-beta over a 7-day period reduced both IGF-I release and the incorporation of [methyl-3H]thymidine into trichloroacetic acid-precipitable cellular material, while preincubation of cells with NaI (0.1 mmol/l) for 24 h prior to the addition of TSH reduced the stimulatory effect of the latter on IGF-I release over the following 7 days.	Sodium Iodide	276-279	transforming growth factor beta 1	Homo sapiens	82-90
2283637-8	1990	A linear correlation existed between Nai and both systolic (SBP) and diastolic (DBP) (r = 0.378 and 0.339, respectively; P less than 0.01), which was strongest among the blacks, particularly the US blacks (SBP vs. Nai, r = 0.716, P less than 0.01).	Sodium Iodide	37-40	selenium binding protein 1	Homo sapiens	60-63
2283637-8	1990	A linear correlation existed between Nai and both systolic (SBP) and diastolic (DBP) (r = 0.378 and 0.339, respectively; P less than 0.01), which was strongest among the blacks, particularly the US blacks (SBP vs. Nai, r = 0.716, P less than 0.01).	Sodium Iodide	37-40	D-box binding PAR bZIP transcription factor	Homo sapiens	80-83
2283637-8	1990	A linear correlation existed between Nai and both systolic (SBP) and diastolic (DBP) (r = 0.378 and 0.339, respectively; P less than 0.01), which was strongest among the blacks, particularly the US blacks (SBP vs. Nai, r = 0.716, P less than 0.01).	Sodium Iodide	37-40	selenium binding protein 1	Homo sapiens	206-209
2283637-8	1990	A linear correlation existed between Nai and both systolic (SBP) and diastolic (DBP) (r = 0.378 and 0.339, respectively; P less than 0.01), which was strongest among the blacks, particularly the US blacks (SBP vs. Nai, r = 0.716, P less than 0.01).	Sodium Iodide	214-217	selenium binding protein 1	Homo sapiens	60-63
2283637-8	1990	A linear correlation existed between Nai and both systolic (SBP) and diastolic (DBP) (r = 0.378 and 0.339, respectively; P less than 0.01), which was strongest among the blacks, particularly the US blacks (SBP vs. Nai, r = 0.716, P less than 0.01).	Sodium Iodide	214-217	D-box binding PAR bZIP transcription factor	Homo sapiens	80-83
34806438-1	2022	The sodium-iodide symporter (NIS, SLC5A5) is expressed at the basolateral membrane of the thyroid follicular cell, and facilitates the thyroidal iodide uptake required for thyroid hormone biosynthesis.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
32797940-0	2020	Corrigendum to Upregulation of sodium iodide symporter (NIS) protein expression by an innate immunity component: Promising potential for targeting radiosensitive retinoblastoma [Exp.	Sodium Iodide	31-44	muscleblind like splicing regulator 1	Homo sapiens	178-181
34774885-10	2022	In patients receiving FDY-5301, there was a significant reduction in the levels of MPO, MMP2 and NTproBNP after PPCI, but no reduction with placebo.	Sodium Iodide	22-30	myeloperoxidase	Homo sapiens	83-86
34774885-10	2022	In patients receiving FDY-5301, there was a significant reduction in the levels of MPO, MMP2 and NTproBNP after PPCI, but no reduction with placebo.	Sodium Iodide	22-30	matrix metallopeptidase 2	Homo sapiens	88-92
34726504-0	2022	A critical balance between Pax8 and the Hippo mediator TAZ determines sodium-iodide symporter NIS expression and function.	Sodium Iodide	70-83	paired box 8	Mus musculus	27-31
34726504-0	2022	A critical balance between Pax8 and the Hippo mediator TAZ determines sodium-iodide symporter NIS expression and function.	Sodium Iodide	70-83	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	55-58
24898835-1	2014	Approximately 30% of patients with advanced, metastatic differentiated thyroid cancer have radioiodine-refractory disease, based on decreased expression of the sodium iodide symporter SLC5A5 (NIS), diminished membrane targeting of NIS, or both.	Sodium Iodide	160-173	solute carrier family 5 member 5	Homo sapiens	184-190
34806438-1	2022	The sodium-iodide symporter (NIS, SLC5A5) is expressed at the basolateral membrane of the thyroid follicular cell, and facilitates the thyroidal iodide uptake required for thyroid hormone biosynthesis.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	34-40
34387194-1	2021	The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active iodide transport into the thyroid gland and into several extrathyroidal tissues.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
34520744-1	2022	The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
34771624-1	2021	The functional expression of the sodium-iodide symporter (NIS) at the membrane of differentiated thyroid cancer (DTC) cells is the cornerstone for the use of radioiodine (RAI) therapy in these malignancies.	Sodium Iodide	33-46	solute carrier family 5 member 5	Homo sapiens	58-61
35503582-0	2022	The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
34368208-1	2021	Background: The sodium iodide symporter is responsible for the transfer of iodine into breast milk and is encoded for by the SLC5A5 gene.	Sodium Iodide	16-29	solute carrier family 5 member 5	Homo sapiens	125-131
35171716-2	2022	METHODS: The early growth response protein 1 (Egr1)-human sodium iodide symporter (hNIS) gene was transfected into BMSCs by lentiviral transfection and the expression levels were evaluated by RT-PCR.	Sodium Iodide	58-71	early growth response 1	Homo sapiens	13-44
35171716-2	2022	METHODS: The early growth response protein 1 (Egr1)-human sodium iodide symporter (hNIS) gene was transfected into BMSCs by lentiviral transfection and the expression levels were evaluated by RT-PCR.	Sodium Iodide	58-71	early growth response 1	Homo sapiens	46-50
35503582-1	2022	Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene.	Sodium Iodide	15-28	solute carrier family 5 member 5	Homo sapiens	40-43
35503582-1	2022	Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene.	Sodium Iodide	15-28	solute carrier family 5 member 5	Homo sapiens	88-91
35146614-6	2022	As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB).	Sodium Iodide	268-281	solute carrier organic anion transporter family member 1B3	Homo sapiens	83-124
35146614-6	2022	As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB).	Sodium Iodide	268-281	solute carrier organic anion transporter family member 1B3	Homo sapiens	126-133
2921318-6	1989	Transforming growth factor beta protein secretion by cultured thyroid follicular cells was also low in nontoxic goiter, but could be increased by addition of sodium iodide (10 microM) to the culture medium.	Sodium Iodide	158-171	transforming growth factor beta 1	Homo sapiens	0-31
35024377-1	2022	CF33-hNIS-anti-PD-L1 is an oncolytic chimeric poxvirus encoding two transgenes: human sodium iodide symporter and a single-chain variable fragment against PD-L1.	Sodium Iodide	86-99	CD274 molecule	Homo sapiens	15-20
2481575-1	1989	We have investigated the influence of antithyroid drugs (methimazole and propylthiouracil) and sodium iodide on the expression of major histocompatibility (MHC) class II antigen expression in human and rat thyroid cells.	Sodium Iodide	95-108	major histocompatibility complex, class II, DR beta 6 (pseudogene)	Homo sapiens	130-177
35267576-5	2022	Furthermore, targeting IGF2BP2 increased 125I uptake in RR-PTC cell lines and enhanced the sodium/iodide symporter (NIS) expression.	Sodium Iodide	91-104	insulin like growth factor 2 mRNA binding protein 2	Homo sapiens	23-30
2547642-11	1989	Net proton efflux via Na:H exchange increased with decreasing pHi and was enhanced by depleting cells of Nai, suggesting roles for both pHi and Nai in control of Na:H activation.	Sodium Iodide	105-108	glucose-6-phosphate isomerase	Homo sapiens	136-139
2661062-11	1989	The present data indicate that: (i) the expression of M/TPO-AG in human thyroid cells is dependent on TSH stimulation, through pathways which involve cAMP production and protein synthesis, (ii) TSAb reproduces this effect of TSH; (iii) oestradiol and NaI have no direct influence on the expression of M/TPO-Ag.	Sodium Iodide	251-254	thyroid peroxidase	Homo sapiens	56-59
3723192-2	1986	Iodine-125 (125I) and iodine-131- (131I) 6-iodocholest-5-en-3 beta-ol has been prepared directly from 6-chloromercuricholest-5-en-3 beta-ol and [125I] or [131I]sodium iodide.	Sodium Iodide	160-173	integrin subunit beta 1	Rattus norvegicus	62-69
2541250-5	1989	Net Na+ influx (Nai less than 2.0 mmol/liter cell, Nao = 150 mM) increased sigmoidally (Hill coefficient 2.5) when pHi fell below 7.0 and the external pHo was 8.0, but increased linearly at pHo 6.0.	Sodium Iodide	16-19	glucose-6-phosphate isomerase	Homo sapiens	115-118
20504533-1	1989	In vivo effective pharmacological procedures are described which markedly increase activity of serotonin N-acetyltransferase (NAT), the key regulatory enzyme in melatonin biosynthesis, during the daytime (in light) and counteract suppressive effects of light on NAI activity at night in the hen retina and pineal gland.	Sodium Iodide	262-265	aralkylamine N-acetyltransferase	Homo sapiens	95-124
20504533-1	1989	In vivo effective pharmacological procedures are described which markedly increase activity of serotonin N-acetyltransferase (NAT), the key regulatory enzyme in melatonin biosynthesis, during the daytime (in light) and counteract suppressive effects of light on NAI activity at night in the hen retina and pineal gland.	Sodium Iodide	262-265	bromodomain containing 2	Homo sapiens	126-129
3619923-2	1987	Inhibitory activity is lost after treatment with NaBH4, NaCNBH3, or NaI, from which we conclude that calmodulin inhibition is due to one or more cholesterol hydroperoxides.	Sodium Iodide	68-71	calmodulin	Oryctolagus cuniculus	101-111
2947479-7	1986	Digestion of control heart sarcolemmal vesicles with exogenous phospholipase A2 (0.02-0.06 unit/500 micrograms protein) inhibited Na+-Ca2+ exchange activity measured as Nai+-dependent 45Ca2+ uptake, and the inhibition was concentration dependent.	Sodium Iodide	169-173	phospholipase A2 group IB	Canis lupus familiaris	63-79
3003189-3	1985	In the present study, left ventricular Na+K+ATPase activity from rats with RRM-saline hypertension was found to be decreased in membranes prepared by two independent methods: deoxycholate, sodium iodide (Nal)-treated microsomal fractions (method 1) and membranes prepared by the hypotonic, lithium bromide (LiBr) method (method 2).	Sodium Iodide	189-202	RNA binding motif protein 39	Rattus norvegicus	75-78
6325278-4	1984	Within an alkali cation series (e.g. NaCH3CO2, NaF, NaCl, NaBr, NaNO3, NaI or a similar potassium series) the affinity decreased with decreasing B coefficient of viscosity.	Sodium Iodide	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	47-50
2578520-2	1985	The HTA 1 subset is defined by NAI/34, D47, or 10H3.9 cross-reactive m.Ab.	Sodium Iodide	31-34	CD1a molecule	Homo sapiens	4-9
6498633-4	1984	Autoradiography of thin layer chromatograms of 125I-labelled AII treated with microsomes showed the parent peak (Rf = 0.4-0.45) and a single major degradation product peak (Rf = 0.25-0.30), and [125I]NaI had an Rf value higher than both 125I-labelled AII and its degradation product.	Sodium Iodide	200-203	angiotensinogen	Rattus norvegicus	61-64
6378635-6	1984	(2) The spectral effects are induced by the very same conditions which are known to induce the 2Zn----4Zn insulin transformation in the crystal (i.e. threshold concentrations of NaCl, KSCN, NaI, for example).	Sodium Iodide	190-193	insulin	Homo sapiens	106-113
6325586-13	1984	At normal Nai+ values, the Nao+/Hi+ antiport of thymocytes is ideally suited for the regulation of pHi.	Sodium Iodide	10-14	glucose-6-phosphate isomerase	Rattus norvegicus	99-102
6371846-8	1984	With a 125I-insulin infusion site at 5 mm depth in the subcutaneous tissue of rabbits, an overall linear proportionality was found between the results obtained with a NaI(Tl) detector and a GM detector raised 15 mm above the skin surface inside the detector housing.	Sodium Iodide	167-170	insulin	Oryctolagus cuniculus	12-19
6169673-8	1981	OKT6 and NAI/34 both recognize a 49,000 glycoprotein which is associated with a 12,000 subunit which reacts with anti-beta 2-microglobulin antibodies.	Sodium Iodide	9-12	beta-2-microglobulin	Homo sapiens	118-138
6583032-2	1984	The bremsstrahlung produced by P-32 beta rays in the pheresis bags allowed the quantitation of radioactivity by well counting in a sodium iodide detector and by a gamma camera.	Sodium Iodide	131-144	inhibitor of growth family member 2	Homo sapiens	31-35
6849912-2	1983	The order of cation effectiveness in inhibiting initial rates of Nai+-induced Ca2+ uptake in the presence of 140 mM Nai+ and 20 microM Cao2+ is La3+ greater than Nd3+ greater than Tm3+ approximately Y3+ greater than Cd2+ much greater than Sr2+ greater than Ba2+ approximately Mn2+ much greater than Mg2+.	Sodium Iodide	65-69	CD2 molecule	Canis lupus familiaris	216-219
893788-8	1977	The large NaI dose markedly reduced transport into compartments of the thyroid trap, the saliva, and the stomach and small intestine.	Sodium Iodide	10-13	TRAP	Homo sapiens	79-83
6263800-3	1981	The inhibition of MPO-mediated iodination was not solely due to lack of H2O availability as a result of decreased HMS activity but also to a primary inhibition of iodination as shown in a cell-free system with horse-radish peroxidase (HRP) and added H2O2 and sodium iodide.	Sodium Iodide	259-272	myeloperoxidase	Equus caballus	18-21
357721-7	1978	The optimal ratios of Me3Si-FU, Thf-OAc, and SnCl4 or NaI for preparation of Thf-FU and Thf2-FU were determined.	Sodium Iodide	54-57	thin fur	Mus musculus	77-80
225674-5	1979	When the [Ca2+]i is well above the physiological range, Ca efflux becomes only partially dependent on ATP (acting now with low affinity), is inhibited by Nai and is stimulated by Na0 and Ca0 (Na--Ca exchange).	Sodium Iodide	154-157	carbonic anhydrase 2	Homo sapiens	10-13
207742-8	1978	Kinetic studies in a cell-free system with purified MPO revealed a competitive type of inhibition using varying concentrations of NaI.	Sodium Iodide	130-133	myeloperoxidase	Homo sapiens	52-55
1271041-5	1976	The actions of Nai and Ko are different when ouabain binding is promoted by Pi and UTPi compared to inside adenosine triphosphate (ATPi).	Sodium Iodide	15-18	ATP synthase inhibitory factor subunit 1	Homo sapiens	131-135
1271041-6	1976	With ATPi, the ouabain binding rate is only affected when Nai and Ko are both present.	Sodium Iodide	58-61	ATP synthase inhibitory factor subunit 1	Homo sapiens	5-9
4692744-0	1973	[Effect of sodium iodide on water content of the Lig.	Sodium Iodide	11-24	ubiquitin conjugating enzyme E2 K	Bos taurus	49-52
175094-9	1976	In mice on a low-iodine diet (LID) but not in animals on a regular diet (RD) NaI pretreatment also blunted TSH-induced thyroidal ODC activation and 131I release.	Sodium Iodide	77-80	ornithine decarboxylase, structural 1	Mus musculus	129-132
33720270-1	2021	The human sodium iodide symporter (hNIS) can be linked to the downstream of radiation-sensitive early growth response protein1 (Egr1) promoter, and activated by the Egr1 following 131I treatment.	Sodium Iodide	10-23	solute carrier family 5 member 5	Homo sapiens	35-39
33831503-3	2021	However, in part of the patients, a reduction of the sodium-iodide symporter (NIS) occurs, rendering radioiodine therapy ineffective.	Sodium Iodide	53-66	solute carrier family 5 member 5	Homo sapiens	78-81
33720270-1	2021	The human sodium iodide symporter (hNIS) can be linked to the downstream of radiation-sensitive early growth response protein1 (Egr1) promoter, and activated by the Egr1 following 131I treatment.	Sodium Iodide	10-23	early growth response 1	Homo sapiens	96-126
33720270-1	2021	The human sodium iodide symporter (hNIS) can be linked to the downstream of radiation-sensitive early growth response protein1 (Egr1) promoter, and activated by the Egr1 following 131I treatment.	Sodium Iodide	10-23	early growth response 1	Homo sapiens	128-132
33720270-1	2021	The human sodium iodide symporter (hNIS) can be linked to the downstream of radiation-sensitive early growth response protein1 (Egr1) promoter, and activated by the Egr1 following 131I treatment.	Sodium Iodide	10-23	early growth response 1	Homo sapiens	165-169
33815280-1	2021	Background and Objectives: Defects in the human sodium/iodide symporter (SLC5A5) gene have been reported to be one of the causes of congenital hypothyroidism (CH).	Sodium Iodide	48-61	solute carrier family 5 member 5	Homo sapiens	73-79
33176626-14	2021	DICER1 silencing decreased PAX8 expression and, importantly, the expression and activity of the sodium iodide symporter NIS, which is essential for the diagnostic and therapeutic use of radioiodine in thyroid cancer.	Sodium Iodide	96-109	dicer 1, ribonuclease III	Homo sapiens	0-6
33583874-2	2021	Uptake of iodine into the thyroid follicle is mediated mainly by the basolateral sodium-iodide symporter (NIS or solute carrier family 5 member 5: SLC5A5), and iodine efflux across the apical membrane into the follicular lumen is mediated by pendrin (SLC26A4).	Sodium Iodide	81-94	solute carrier family 5 member 5	Rattus norvegicus	113-145
33583874-2	2021	Uptake of iodine into the thyroid follicle is mediated mainly by the basolateral sodium-iodide symporter (NIS or solute carrier family 5 member 5: SLC5A5), and iodine efflux across the apical membrane into the follicular lumen is mediated by pendrin (SLC26A4).	Sodium Iodide	81-94	solute carrier family 5 member 5	Rattus norvegicus	147-153
33038323-1	2021	The sodium iodide symporter (NIS) is widely used as a reporter gene to noninvasively monitor the biodistribution and durability of vector-mediated gene expression via gamma scintigraphy, single-photon emission computed tomography (SPECT), and positron-emission tomography (PET).	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
33339472-4	2021	Sodium iodide symporter (NIS) is an intrinsic membrane glycoprotein and can concentrate 131I, which is important for radionuclide therapy and nuclear medicine imaging in recent years.	Sodium Iodide	0-13	solute carrier family 5 member 5	Homo sapiens	25-28
33511173-1	2021	BACKGROUND: A proportion of lung cancers show sodium/iodide symporter (NIS) expression.	Sodium Iodide	46-59	solute carrier family 5 member 5	Homo sapiens	71-74
33002449-2	2021	The sodium iodide symporter (NIS) transports iodide across mammalian intestinal and thyroid epithelia to deliver iodide for thyroid hormone production.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
32300552-0	2020	Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer.	Sodium Iodide	21-34	thyroid stimulating hormone receptor	Homo sapiens	90-94
32645298-6	2020	Here, we employed the human sodium iodide symporter to non-invasively quantify tumor retention of pan-ErbB family targeted CAR-T by PET.	Sodium Iodide	28-41	CXADR pseudogene 1	Homo sapiens	123-126
33009242-0	2020	Combination of peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells.	Sodium Iodide	105-118	peroxisome proliferator activated receptor gamma	Homo sapiens	15-63
33009242-0	2020	Combination of peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells.	Sodium Iodide	105-118	retinoid X receptor alpha	Homo sapiens	68-87
33009242-3	2020	The sodium/iodide symporter (NIS) has positive expression in thyroid carcinomas with good prognoses and plays a critical role in radioiodine therapy response.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
32532820-3	2020	In vitro, MED16 overexpression in PTC cells significantly inhibited cell migration, enhanced sodium/iodide symporter (NIS) expression and iodine uptake, and decreased resistance to radioactive 131I (RAI).	Sodium Iodide	93-106	mediator complex subunit 16	Homo sapiens	10-15
33293661-2	2020	Efforts have been made to restore sodium-iodide symporter (NIS) expression in ATC cells where it has been downregulated, yet without complete success.	Sodium Iodide	34-47	solute carrier family 5 member 5	Homo sapiens	59-62
32168263-1	2020	OBJECTIVE: To report on the associations between BRAF and sodium iodide symporter expressions and treatment outcomes in patients with papillary thyroid carcinoma.	Sodium Iodide	58-71	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	49-53
32336951-6	2020	Human sodium/iodide symporter (hNIS) is considered as one of the most prevalent nuclear imaging reporter transgenes that provides precise information regarding the kinetics of gene expression, viral biodistribution, toxicity, and therapeutic outcomes using the accumulation of radiotracers at the site of transgene expression.	Sodium Iodide	6-19	solute carrier family 5 member 5	Homo sapiens	31-35
32032721-3	2020	STUDY DESIGN: CF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody (anti-PD-L1).	Sodium Iodide	112-125	CD274 molecule	Homo sapiens	173-178
32300552-0	2020	Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer.	Sodium Iodide	21-34	cAMP responsive element binding protein 1	Homo sapiens	100-104
32300552-0	2020	Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer.	Sodium Iodide	21-34	paired box 8	Homo sapiens	105-109
32049985-0	2020	TNFalpha-mediated activation of NF-kappaB downregulates sodium-iodide symporter expression in thyroid cells.	Sodium Iodide	56-69	tumor necrosis factor	Homo sapiens	0-8
32134653-0	2020	Mapping of Ion and Substrate Binding Sites in Human Sodium Iodide Symporter (hNIS).	Sodium Iodide	52-65	solute carrier family 5 member 5	Homo sapiens	77-81
32134653-1	2020	The human sodium iodide symporter (hNIS) is a theranostic reporter gene which concentrates several clinically approved SPECT and PET radiotracers and plays an essential role for the synthesis of thyroid hormones as an iodide transporter in the thyroid gland.	Sodium Iodide	10-23	solute carrier family 5 member 5	Homo sapiens	35-39
32084174-0	2020	Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS).	Sodium Iodide	99-112	solute carrier family 5 member 5	Homo sapiens	124-127
32084174-1	2020	The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroid hormone production.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
32049985-0	2020	TNFalpha-mediated activation of NF-kappaB downregulates sodium-iodide symporter expression in thyroid cells.	Sodium Iodide	56-69	nuclear factor kappa B subunit 1	Homo sapiens	32-41
32049985-1	2020	The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
31129420-8	2019	RESULTS: The mRNA and protein expression of Gas6 was significantly lower in the NaI group compared to the control group.	Sodium Iodide	80-83	growth arrest specific 6	Mus musculus	44-48
31548345-1	2019	PURPOSE: To investigate the presence of ESR1 mutations in primary estrogen-receptor-positive (ER+) breast cancer treated with extended (>4 weeks) neoadjuvant (presurgical) aromatase inhibitor (NAI) therapy and to identify patients who may gain less benefit from aromatase inhibition (AI) alone based upon on-treatment changes in gene expression.	Sodium Iodide	193-196	estrogen receptor 1	Homo sapiens	40-44
31548345-5	2019	ESR1-mutant tumors showed increased expression of ESR1 transcript and limited suppression of ERGs and proliferation-associated genes in response to NAI.	Sodium Iodide	148-151	estrogen receptor 1	Homo sapiens	0-4
31196853-1	2019	PURPOSE: The innate tumor homing potential of mesenchymal stem cells (MSCs) has been used for a targeted delivery of the theranostic sodium iodide symporter (NIS) transgene into solid tumors.	Sodium Iodide	133-146	solute carrier family 5 member 5	Homo sapiens	158-161
31533238-7	2019	The sodium iodide symporter (NIS) is a plasma membrane glycoprotein, a member of solute carrier family 5A (SLC5A5), located on the basolateral surfaces of the thyroid follicular epithelial cells, which mediates active iodide transport into thyroid follicular cells.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	107-113
31672844-0	2020	Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 (ARF4) and valosin-containing protein (VCP) enhances radioiodine uptake.	Sodium Iodide	16-29	ADP ribosylation factor 4	Homo sapiens	52-77
31672844-0	2020	Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 (ARF4) and valosin-containing protein (VCP) enhances radioiodine uptake.	Sodium Iodide	16-29	ADP ribosylation factor 4	Homo sapiens	79-83
31672844-0	2020	Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 (ARF4) and valosin-containing protein (VCP) enhances radioiodine uptake.	Sodium Iodide	16-29	valosin containing protein	Homo sapiens	89-115
31672844-0	2020	Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 (ARF4) and valosin-containing protein (VCP) enhances radioiodine uptake.	Sodium Iodide	16-29	valosin containing protein	Homo sapiens	117-120
31585718-0	2020	Dual inhibition of BRAF and MEK increases expression of sodium iodide symporter in patient-derived papillary thyroid cancer cells in vitro.	Sodium Iodide	56-69	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	19-23
31585718-0	2020	Dual inhibition of BRAF and MEK increases expression of sodium iodide symporter in patient-derived papillary thyroid cancer cells in vitro.	Sodium Iodide	56-69	mitogen-activated protein kinase kinase 7	Homo sapiens	28-31
31585718-2	2020	This process leads to malignant transformation, dedifferentiation, and a decrease in the expression of the sodium-iodide symporter (NIS; SLC5A5), which results in resistance to radioactive iodine therapy.	Sodium Iodide	107-120	solute carrier family 5 member 5	Homo sapiens	137-143
31437501-3	2019	The intrinsic viscosity, [eta], is markedly changed by the presence of different monovalent salts (NaCl, NaI and CsI).	Sodium Iodide	105-108	endothelin receptor type A	Homo sapiens	26-29
31010838-1	2019	PURPOSE: New strategies to restore sodium iodide symporter (NIS) expression and function in radioiodine therapy-refractive anaplastic thyroid cancers (ATCs) are urgently required.	Sodium Iodide	35-48	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	60-63
31129420-9	2019	Serum levels of TgAb, TNF-alpha, IL-6 and IL-1beta were also significantly higher in the NaI group but were dramatically reduced after rmGas6 injection.	Sodium Iodide	89-92	tumor necrosis factor	Mus musculus	22-31
31129420-9	2019	Serum levels of TgAb, TNF-alpha, IL-6 and IL-1beta were also significantly higher in the NaI group but were dramatically reduced after rmGas6 injection.	Sodium Iodide	89-92	interleukin 6	Mus musculus	33-37
31129420-9	2019	Serum levels of TgAb, TNF-alpha, IL-6 and IL-1beta were also significantly higher in the NaI group but were dramatically reduced after rmGas6 injection.	Sodium Iodide	89-92	interleukin 1 beta	Mus musculus	42-50
30881348-9	2019	In vitro, we generated a stable thyroid cell line PCCL3 with FAM83F overexpression and observed that FAM83F deregulates thyroid follicular cell biology leading to loss of thyroid differentiation genes such as Sodium-Iodide Symporter (NIS), reactivation of stem cell markers such as LIN28B and SOX2, induction of cell migration and resistance to doxorubicin-induced apoptosis.	Sodium Iodide	209-222	family with sequence similarity 83 member F	Homo sapiens	101-107
31296047-1	2019	BACKGROUND: We propose micro single-photon emission computed tomography/computed tomography imaging of the hNIS (human sodium/iodide symporter) to noninvasively quantify adeno-associated virus 9 (AAV9)-mediated gene expression in a murine model of peripheral artery disease.	Sodium Iodide	119-132	solute carrier family 5 member 5	Homo sapiens	107-111
30847493-5	2019	In Arabidopsis, CRR42 associates only with an NDH-1 hydrophilic arm assembly intermediate (NAI) of about 400 kDa (NAI400), one of total three NAIs (NAI800, NAI500 and NAI400), and its deletion has little, if any, effect on accumulation of any NAIs in the stroma.	Sodium Iodide	142-146	DUF3148 family protein	Arabidopsis thaliana	16-21
30847493-5	2019	In Arabidopsis, CRR42 associates only with an NDH-1 hydrophilic arm assembly intermediate (NAI) of about 400 kDa (NAI400), one of total three NAIs (NAI800, NAI500 and NAI400), and its deletion has little, if any, effect on accumulation of any NAIs in the stroma.	Sodium Iodide	243-247	DUF3148 family protein	Arabidopsis thaliana	16-21
31127889-2	2019	After confirming the segregation by the flow cytometry method,BRAF and sodium-iodide symporter (NIS) genes were investigated in them before and after incubation with BRAFinhibitor.	Sodium Iodide	71-84	solute carrier family 5 member 5	Homo sapiens	96-99
31061881-5	2019	We have thus used homologous recombination and high-throughput screening to create a novel chimeric poxvirus encoding a human sodium iodide symporter (hNIS) at a redundant tk locus.	Sodium Iodide	126-139	solute carrier family 5 member 5	Homo sapiens	151-155
30932012-1	2019	Sufficient thyroid iodine uptake is needed to ensure effective radioactive iodine (RAI) treatment, which is mediated by the sodium-iodide symporter (NIS).	Sodium Iodide	124-137	solute carrier family 5 member 5	Homo sapiens	149-152
30260223-0	2018	Generation of ArS- and ArSe-Substituted 4-Quinolone Derivatives Using Sodium Iodide As an Inducer.	Sodium Iodide	70-83	RIEG2	Homo sapiens	14-17
30657313-0	2019	Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.	Sodium Iodide	120-133	estrogen related receptor gamma	Homo sapiens	56-87
30657313-1	2019	An inverse agonist of estrogen-related receptor-gamma (ERRgamma), an orphan nuclear receptor encoded by E srrg, enhances sodium iodide symporter-mediated radioiodine uptake in anaplastic thyroid cancer (ATC) cells, thereby facilitating responsiveness to radioiodine therapy in vitro.	Sodium Iodide	121-134	estrogen related receptor gamma	Homo sapiens	22-53
30657313-1	2019	An inverse agonist of estrogen-related receptor-gamma (ERRgamma), an orphan nuclear receptor encoded by E srrg, enhances sodium iodide symporter-mediated radioiodine uptake in anaplastic thyroid cancer (ATC) cells, thereby facilitating responsiveness to radioiodine therapy in vitro.	Sodium Iodide	121-134	estrogen related receptor gamma	Homo sapiens	55-63
30847387-6	2019	Combined treatment with panobinostat and MAPKi (dabrafenib or selumetinib) displayed a more robust BRAF V600E-dependent redifferentiation effect than panobinostat alone via further improving the acetylation level of histone at the sodium-iodide symporter (NIS) promoter.	Sodium Iodide	231-244	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	99-103
30774126-3	2019	In in vitro SHAPE, an RNA sequence of 140 nucleotides containing SMN2 exon 7 is transcribed by T7 RNA polymerase, folded in the presence of SMN-C2, and subsequently modified by a mild 2"-OH acylation reagent, 2-methylnicotinic acid imidazolide (NAI).	Sodium Iodide	245-248	survival of motor neuron 2, centromeric	Homo sapiens	65-69
30217930-0	2018	A Nonpump Function of Sodium Iodide Symporter in Thyroid Cancer via Cross-talk with PTEN Signaling.	Sodium Iodide	22-35	phosphatase and tensin homolog	Homo sapiens	84-88
30217930-1	2018	The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	29-32
30217930-1	2018	The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers.	Sodium Iodide	4-17	solute carrier family 5 member 5	Homo sapiens	137-140
30760304-6	2019	RESULTS: Low dose radiation (LDR)-induced PAX8 upregulation restores not only BRAF-suppressive sodium/iodide symporter (NIS) expression, one of the major protein necessary for iodine uptake in healthy thyroid, on plasma membrane but also regulate other thyroid metabolizing genes levels.	Sodium Iodide	95-108	paired box 8	Homo sapiens	42-46
30760304-6	2019	RESULTS: Low dose radiation (LDR)-induced PAX8 upregulation restores not only BRAF-suppressive sodium/iodide symporter (NIS) expression, one of the major protein necessary for iodine uptake in healthy thyroid, on plasma membrane but also regulate other thyroid metabolizing genes levels.	Sodium Iodide	95-108	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	78-82
30121623-2	2019	Transgenic expression of the sodium iodide symporter (NIS) in genetically engineered MSCs allows noninvasive tracking of MSC homing by imaging of functional NIS expression as well as therapeutic application of 131I.	Sodium Iodide	29-42	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	54-57
30121623-2	2019	Transgenic expression of the sodium iodide symporter (NIS) in genetically engineered MSCs allows noninvasive tracking of MSC homing by imaging of functional NIS expression as well as therapeutic application of 131I.	Sodium Iodide	29-42	solute carrier family 5 (sodium iodide symporter), member 5	Mus musculus	157-160
30260223-0	2018	Generation of ArS- and ArSe-Substituted 4-Quinolone Derivatives Using Sodium Iodide As an Inducer.	Sodium Iodide	70-83	arylsulfatase L	Homo sapiens	23-27
30260223-1	2018	An operationally simple sodium iodide-mediated C-S and C-Se bond formation protocol involving substituted 4-quinolone and thiols/diselenide to generate different ArS/ArSe-substituted 4-quinolone derivatives in excellent yields was developed.	Sodium Iodide	24-37	RIEG2	Homo sapiens	162-165
30260223-1	2018	An operationally simple sodium iodide-mediated C-S and C-Se bond formation protocol involving substituted 4-quinolone and thiols/diselenide to generate different ArS/ArSe-substituted 4-quinolone derivatives in excellent yields was developed.	Sodium Iodide	24-37	arylsulfatase L	Homo sapiens	166-170
30337961-0	2018	Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells.	Sodium Iodide	82-95	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	149-153
30186235-10	2018	More recently, it has been shown that NF-kappaB also has a role in thyroid physiology, as it is fundamental for the expression of the main thyroid-specific genes, such as sodium iodide symporter, thyroid peroxidase, thyroglobulin, Pax8, and TTF-1 (NKX2-1).	Sodium Iodide	171-184	nuclear factor kappa B subunit 1	Homo sapiens	38-47
30337961-0	2018	Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells.	Sodium Iodide	82-95	mitogen-activated protein kinase kinase 7	Homo sapiens	26-29
30337961-0	2018	Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells.	Sodium Iodide	82-95	mitogen-activated protein kinase 1	Homo sapiens	30-33
30337961-0	2018	Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells.	Sodium Iodide	82-95	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	38-42
30018229-2	2018	We aimed to analyse the effect of selumetinib on the expression of sodium iodide symporter (NIS; SLC5A5) and associated miRNAs in thyroid cancer cells.	Sodium Iodide	67-80	solute carrier family 5 member 5	Homo sapiens	97-103
29845997-0	2018	A robust Zn(ii)/Na(i)-MOF decorated with [(OAc)2(H2O)2]n2n- anions for the luminescence sensing of copper ions based on the inner filter effect.	Sodium Iodide	16-21	lysine acetyltransferase 8	Homo sapiens	22-25
29563296-8	2018	Importantly, neuraminidase (NA) inhibitor (NAI) resistance (R292K in NA) and mammalian adaptation (e.g., E627K and A588V in PB2) mutations were found in a few non-human-derived HP-H7N9 strains.	Sodium Iodide	43-46	neuraminidase 1	Homo sapiens	13-26
29131623-2	2017	Herein, we evaluate structural and functional similarities between SMCT1 and the well-studied sodium-iodide symporter (NIS) that mediates the first step of iodide entry into the thyroid.	Sodium Iodide	94-107	solute carrier family 5 member 8	Homo sapiens	67-72
29540684-5	2018	Here we show the utility of the human sodium iodide symporter (hNIS) for the temporal and spatial monitoring of CAR T-cell behavior in a cancer-bearing host.	Sodium Iodide	38-51	nuclear receptor subfamily 1 group I member 3	Homo sapiens	112-115
29298843-2	2018	The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS) (codified by the SLC5A5 gene), that is functional only when targeted to the cell membrane.	Sodium Iodide	64-77	solute carrier family 5 member 5	Homo sapiens	89-92
29298843-2	2018	The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS) (codified by the SLC5A5 gene), that is functional only when targeted to the cell membrane.	Sodium Iodide	64-77	solute carrier family 5 member 5	Homo sapiens	111-117
29561759-2	2018	Cell proliferation inhibitory effects of the pan-deacetylase inhibitors panobinostat, SAHA and Trichostatin A (TSA), the modulation of the sodium iodide symporter (NIS; SLC5A5), thyroid transcription factor 1 (TTF1), high mobility group A2 (HMGA2), and H19 and their putative targeting miRNAs have been evaluated in vitro.	Sodium Iodide	139-152	solute carrier family 5 member 5	Homo sapiens	169-175
31966449-5	2017	The survivin promoter, which has tumor-selective capability, was used to construct an adenoviral vector, and its feasibility to carry the sodium iodide symporter (NIS) gene for potential tumor-targeting transfection into carcinoma was evaluated in this study.	Sodium Iodide	138-151	solute carrier family 5 member 5	Homo sapiens	163-166
29063090-6	2017	In contrast, N-Boc-protected and unprotected hybrids formed rectangular columnar (Colr) mesophases with phase widths up to 35 K. NaI complexation switched these neutral thermotropic derivatives into ionic liquid crystals (ILCs) and induced a change of mesophase type from Colr to smectic A (SmA).	Sodium Iodide	129-132	survival of motor neuron 1, telomeric	Homo sapiens	280-289
29063090-6	2017	In contrast, N-Boc-protected and unprotected hybrids formed rectangular columnar (Colr) mesophases with phase widths up to 35 K. NaI complexation switched these neutral thermotropic derivatives into ionic liquid crystals (ILCs) and induced a change of mesophase type from Colr to smectic A (SmA).	Sodium Iodide	129-132	survival of motor neuron 1, telomeric	Homo sapiens	291-294
29085920-7	2017	In particular, the TCI phase of a PbTe monolayer remains when epitaxially grown on a NaI semiconductor substrate.	Sodium Iodide	85-88	latexin	Homo sapiens	19-22
28920531-8	2017	Knockdown of KLF4 expression in ATC cells increased the expression of the thyroid-specific differentiation genes, such as thyrotropin receptor, thyroid peroxidase, thyroglobulin, and sodium-iodide symporter.	Sodium Iodide	183-196	Kruppel like factor 4	Homo sapiens	13-17
28190186-0	2017	Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter.	Sodium Iodide	75-88	anti-Mullerian hormone	Homo sapiens	55-58
28654510-2	2017	The prime antiarrhythmic mechanisms of late INa inhibition have been suggested to be (1) suppression of intracellular calcium [Cai]-mediated rhythmic activity (through reduction in Cai secondary to the decrease in intracellular sodium [Nai]) and (2) normalization of repolarization.	Sodium Iodide	236-239	internexin neuronal intermediate filament protein alpha	Homo sapiens	44-47
28554793-0	2017	Quantifying Na(I)-insulin and K(I)-insulin non-covalent complexes by ESI-MS method and calculation of their equilibrium constants.	Sodium Iodide	12-17	insulin	Homo sapiens	18-25
28554793-1	2017	In this study, the dissociation and formation equilibrium constants of Na(I)-insulin and K(I)-insulin complexes have been calculated after the quantifying them on ESI mass spectrometer.	Sodium Iodide	71-76	insulin	Homo sapiens	77-84
28554793-1	2017	In this study, the dissociation and formation equilibrium constants of Na(I)-insulin and K(I)-insulin complexes have been calculated after the quantifying them on ESI mass spectrometer.	Sodium Iodide	71-76	insulin	Homo sapiens	94-101
28554793-3	2017	The effect of pH on the Na(I)-insulin and K(I)-insulin complex formation were examined.	Sodium Iodide	24-29	insulin	Homo sapiens	30-37
28554793-5	2017	The first formation equilibrium constants were calculated as Kf1: 5.48x103 1/M for Na(I)-insulin complex and Kf1: 4.87x103 1/M for K(I)-insulin in water.	Sodium Iodide	83-88	insulin	Homo sapiens	89-96
28554793-5	2017	The first formation equilibrium constants were calculated as Kf1: 5.48x103 1/M for Na(I)-insulin complex and Kf1: 4.87x103 1/M for K(I)-insulin in water.	Sodium Iodide	83-88	insulin	Homo sapiens	136-143
28554793-8	2017	The results showed that Na(I) and K(I) ions are involved in the formation of the non-covalent complexes with insulin molecule, since high extracellular and intracellular concentrations of them in the body.	Sodium Iodide	24-29	insulin	Homo sapiens	109-116
28938449-3	2017	In human thyrocytes, TSH plus IGF-1 synergistically increased expression of the sodium-iodide symporter that appeared to involve ERK1/2 activation.	Sodium Iodide	80-93	insulin like growth factor 1	Homo sapiens	30-35
28938449-3	2017	In human thyrocytes, TSH plus IGF-1 synergistically increased expression of the sodium-iodide symporter that appeared to involve ERK1/2 activation.	Sodium Iodide	80-93	mitogen-activated protein kinase 3	Homo sapiens	129-135
28654510-4	2017	Late INa influx may significantly contribute to Nai loading, but it seems to largely occur under the combined conditions of augmented late INa density, bradycardia, and prolonged repolarization.	Sodium Iodide	48-51	internexin neuronal intermediate filament protein alpha	Homo sapiens	5-8
28205121-1	2017	INTRODUCTION AND AIM: Previous studies and systematic reviews have not provided conclusive evidence on the effect of N-acetylcysteine (NAC) in non-acetaminophen-induced acute liver failure (NAI-ALF).	Sodium Iodide	190-193	afamin	Homo sapiens	194-197
27401113-0	2017	NADPH Oxidase NOX4 Is a Critical Mediator of BRAFV600E-Induced Downregulation of the Sodium/Iodide Symporter in Papillary Thyroid Carcinomas.	Sodium Iodide	85-98	NADPH oxidase 4	Homo sapiens	14-18
28205121-15	2017	CONCLUSIONS: When administered on admission, intravenous NAC caused a reduction in NAI-ALF mortality and need for transplantation.	Sodium Iodide	83-86	afamin	Homo sapiens	87-90
28363255-12	2017	RESULTS: The mRNA expression of HMGB1 was significantly higher at 8 and 16 weeks in the NaI group than it was in the control group.	Sodium Iodide	88-91	high mobility group box 1	Mus musculus	32-37
28363255-13	2017	Serum levels of thyroglobulin antibodies, HMGB1, tumor necrosis factor alpha, IL-6, and IL-1beta were significantly increased in the NaI group, but they were dramatically attenuated with GL injection.	Sodium Iodide	133-136	interleukin 1 beta	Mus musculus	88-96
28067324-2	2017	Current pandemic preparations involve stock- piling oseltamivir, an oral neuraminidase inhibitor (NAI), so rapidly determining the effectiveness of NAIs against new viral strains is vital for deciding how to use the stockpile.	Sodium Iodide	148-152	neuraminidase 1	Homo sapiens	73-86
27635026-5	2017	METHODS: We incorporated the human sodium iodide symporter (hNIS) and the human somatostatin receptor 2 (hSSR2) in the vaccinia-based OV and tested viral constructs for their abilities to track and treat tumor development in vivo.	Sodium Iodide	35-48	solute carrier family 5 member 5	Homo sapiens	60-64
28379254-2	2017	Catalytic CF2 transfer from Me3SiCF3 to n-butyl acrylate becomes possible when directly using the divalent cobalt(ii) porphyrin catalysts in the presence of NaI.	Sodium Iodide	157-160	ATPase H+ transporting accessory protein 1	Homo sapiens	10-13
27762460-2	2017	This reaction proceeds smoothly in the presence of [CoBr2 (PPh3 )2 ] as the catalyst, with NaI as an additive in acetonitrile with a broad scope of functionalized alkenyl and benzyl halides.	Sodium Iodide	91-94	caveolin 1	Homo sapiens	59-63
27753495-3	2016	We found the transition concentration is ion-specific, and the capacity of sodium halide salts to inhibit bubble coalescence follows the order of NaF > NaCl > NaBr > NaI.	Sodium Iodide	175-178	C-X-C motif chemokine ligand 8	Homo sapiens	146-149
27638195-4	2016	RESULTS: TSH/IGF-1 co-treatment elicited additive effects on thyroglobulin (TG), thyroperoxidase (TPO), and deiodinase type 2 (DIO2) mRNA levels but synergistic effects on sodium-iodide symporter (NIS) mRNA.	Sodium Iodide	172-185	insulin like growth factor 1	Homo sapiens	13-18
27638195-4	2016	RESULTS: TSH/IGF-1 co-treatment elicited additive effects on thyroglobulin (TG), thyroperoxidase (TPO), and deiodinase type 2 (DIO2) mRNA levels but synergistic effects on sodium-iodide symporter (NIS) mRNA.	Sodium Iodide	172-185	iodothyronine deiodinase 2	Homo sapiens	127-131
28386277-1	2017	Radioiodine whole body scan (WBS), related to sodium iodide symporter (NIS) function, is widely used to detect recurrence/metastasis in postoperative patients with thyroid cancer.	Sodium Iodide	46-59	solute carrier family 5 member 5	Homo sapiens	71-74
27614840-1	2016	The sodium/iodide symporter (NIS), which is essential for iodide concentration in the thyroid, is reported to be transcriptionally regulated by sterol regulatory element-binding proteins (SREBP) in rat FRTL-5 thyrocytes.	Sodium Iodide	4-17	solute carrier family 5 member 5	Rattus norvegicus	29-32
27521344-1	2016	Sixty to seventy percent of IFN-gamma(-/-) NOD.H-2h4 mice given sodium iodide (NaI)-supplemented water develop a slow onset autoimmune thyroid disease, characterized by thyrocyte epithelial cell (TEC) hyperplasia and proliferation (H/P).	Sodium Iodide	64-77	interferon gamma	Mus musculus	28-37
27682510-4	2016	TTF1 is required for follicular cell development and disrupting its function abrogates thyroglobulin production and sodium iodide transport.	Sodium Iodide	116-129	NK2 homeobox 1	Homo sapiens	0-4
27682310-1	2016	Sodium iodide is used for the first time as a nucleophile to trap an alpha-imino rhodium carbene, which triggers a tandem process involving intermolecular nucleophilic attack and intramolecular SN2 reaction.	Sodium Iodide	0-13	solute carrier family 38 member 5	Homo sapiens	194-197
27574129-10	2016	Sodium iodide (NaI, 10-5 M) significantly abolished the effects of exogenous CCL21.	Sodium Iodide	0-13	C-C motif chemokine ligand 21	Homo sapiens	77-82
27574129-10	2016	Sodium iodide (NaI, 10-5 M) significantly abolished the effects of exogenous CCL21.	Sodium Iodide	15-18	C-C motif chemokine ligand 21	Homo sapiens	77-82
27574129-11	2016	These results suggest that CCL21/CCR7 interaction contributes to G2/M progression of RET/PTC-expressing cells via the ERK pathway in association with 10-5 M NaI.	Sodium Iodide	157-160	C-C motif chemokine ligand 21	Homo sapiens	27-32
27574129-11	2016	These results suggest that CCL21/CCR7 interaction contributes to G2/M progression of RET/PTC-expressing cells via the ERK pathway in association with 10-5 M NaI.	Sodium Iodide	157-160	C-C motif chemokine receptor 7	Homo sapiens	33-37
27574129-11	2016	These results suggest that CCL21/CCR7 interaction contributes to G2/M progression of RET/PTC-expressing cells via the ERK pathway in association with 10-5 M NaI.	Sodium Iodide	157-160	ret proto-oncogene	Homo sapiens	85-88
27521344-1	2016	Sixty to seventy percent of IFN-gamma(-/-) NOD.H-2h4 mice given sodium iodide (NaI)-supplemented water develop a slow onset autoimmune thyroid disease, characterized by thyrocyte epithelial cell (TEC) hyperplasia and proliferation (H/P).	Sodium Iodide	79-82	interferon gamma	Mus musculus	28-37
26989187-1	2016	In this issue of Blood, Shen et al demonstrate that the vesicular stomatitis virus (VSV)-murine interferon beta (IFNbeta)-sodium iodide symporter (NIS) (VSV-mIFNbeta-NIS) oncolytic virus has significant antileukemia activity, which is enhanced when combined with an anti-programmed death-ligand 1 (PD-L1) antibody.	Sodium Iodide	122-135	interferon beta 1, fibroblast	Mus musculus	96-111
28413608-1	2016	Objectives: The stockpiling of neuraminidase inhibitor (NAI) antivirals as a defence against pandemic influenza is a significant public health policy decision that must be made despite a lack of conclusive evidence from randomised controlled trials regarding the effectiveness of NAIs on important clinical end points such as mortality.	Sodium Iodide	280-284	neuraminidase 1	Homo sapiens	31-44
27180062-0	2016	The correlation of sodium iodide symporter and BRAF(V600E) mutation in classical variant papillary thyroid carcinoma.	Sodium Iodide	19-32	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	47-52
27512388-8	2016	In primary cultures of human thyrocytes, C2, E1, and E2 stimulated increases in thyroperoxidase mRNA of 92-, 55-, and 137-fold and in sodium-iodide symporter mRNA of 20-, 4-, and 121-fold above basal levels, respectively.	Sodium Iodide	134-147	small nucleolar RNA, C/D box 12C	Homo sapiens	45-55
27045654-1	2016	OBJECTIVE: To explore whether nuclear translocation of beta-catenin affects functional expression of sodium iodide symporter (NIS) in human thyroid cancer cells.	Sodium Iodide	101-114	catenin beta 1	Homo sapiens	55-67
27045654-1	2016	OBJECTIVE: To explore whether nuclear translocation of beta-catenin affects functional expression of sodium iodide symporter (NIS) in human thyroid cancer cells.	Sodium Iodide	101-114	solute carrier family 5 member 5	Homo sapiens	126-129
26989187-1	2016	In this issue of Blood, Shen et al demonstrate that the vesicular stomatitis virus (VSV)-murine interferon beta (IFNbeta)-sodium iodide symporter (NIS) (VSV-mIFNbeta-NIS) oncolytic virus has significant antileukemia activity, which is enhanced when combined with an anti-programmed death-ligand 1 (PD-L1) antibody.	Sodium Iodide	122-135	interferon beta 1, fibroblast	Mus musculus	113-120
25896817-5	2015	We aimed at establishing the human sodium iodide symporter (hNIS) as reporter gene for PET monitoring of teratoma formation.	Sodium Iodide	35-48	solute carrier family 5 member 5	Homo sapiens	60-64
26253711-2	2016	Thyroid and breast tissues both express the sodium iodide symporter (NIS), similarly both have a peroxidase activity, TPO and lactoperoxidase (LPO) respectively.	Sodium Iodide	44-57	solute carrier family 5 member 5	Homo sapiens	69-72
26253711-2	2016	Thyroid and breast tissues both express the sodium iodide symporter (NIS), similarly both have a peroxidase activity, TPO and lactoperoxidase (LPO) respectively.	Sodium Iodide	44-57	thyroid peroxidase	Homo sapiens	118-121
26902198-2	2016	METHODS: Three kinds of treatment models were firstly established with alcohol, ATRA, and transfection of beta-catenin shRNA in undifferentiated human thyroid cancer cell line-SW1736.Then the expressions of sodium iodide symporter (NIS), beta-catenin and its regulating factors, epithelial-mensechymal transition (EMT)-phenotype, invasion and metastasis associated proteins were further measured in above three cell models.After that, the influence of ATRA on the functional expression of NIS, iodine uptake potency, tumor growth curve and treatment effect inducing by radioactive iodine was comparatively analyzed in vitro and in vivo trials.	Sodium Iodide	207-220	catenin beta 1	Homo sapiens	106-118
26021458-7	2015	The inhibition of thyroperoxidase activity by methimazole prevented the inhibitory effect of NaI on thyroid monocarboxylate transporter 8 expression, suggesting that an active thyroperoxidase is necessary for MCT8 downregulation by iodine overload, similarly to other thyroid markers, such as sodium iodide symporter.	Sodium Iodide	293-306	solute carrier family 16 member 2	Rattus norvegicus	209-213
25749472-8	2015	Similar correlations are also known for a multitude of transporters, such as glucose transporters, amino acid transporters or hNIS (human sodium iodide symporter), as well as cell specific proteins, such as the prostate specific membrane antigen, integrins, and CD20.	Sodium Iodide	138-151	keratin 20	Homo sapiens	262-266
26338896-0	2015	Inverse Agonist of Estrogen-Related Receptor gamma Enhances Sodium Iodide Symporter Function Through Mitogen-Activated Protein Kinase Signaling in Anaplastic Thyroid Cancer Cells.	Sodium Iodide	60-73	estrogen related receptor gamma	Homo sapiens	19-50
26282166-7	2015	Specifically, we found that miR-146b-3p binds to the 3"-untranslated region of PAX8 and sodium/iodide symporter (NIS), leading to impaired protein translation and a subsequent reduction in iodide uptake.	Sodium Iodide	88-101	microRNA 146b	Homo sapiens	28-36
26282166-7	2015	Specifically, we found that miR-146b-3p binds to the 3"-untranslated region of PAX8 and sodium/iodide symporter (NIS), leading to impaired protein translation and a subsequent reduction in iodide uptake.	Sodium Iodide	88-101	solute carrier family 5 member 5	Homo sapiens	113-116
25953703-8	2015	The 2 most potent chemicals for TPO inhibition, MBT and CMBT, produced responses in vivo indicative of T4 synthesis inhibition including induction of sodium iodide symporter mRNA and decreases in glandular and circulating thyroid hormones.	Sodium Iodide	150-163	thyroid peroxidase S homeolog	Xenopus laevis	32-35
25673705-2	2015	Neuraminidase (NA) inhibitors (NAIs) are the only class of drugs available to treat influenza A and B virus infections, so the development of NAI-resistant viruses with superior fitness is a public health concern.	Sodium Iodide	31-34	neuraminidase 1	Homo sapiens	0-13
25673705-11	2015	The development of resistance to a single class of available antivirals, the neuraminidase (NA) inhibitors (NAIs), is a public health concern.	Sodium Iodide	108-112	neuraminidase 1	Homo sapiens	77-90
25673705-11	2015	The development of resistance to a single class of available antivirals, the neuraminidase (NA) inhibitors (NAIs), is a public health concern.	Sodium Iodide	108-112	neuraminidase 1	Homo sapiens	92-94
25673705-14	2015	We show that virus with an E119A NA substitution can replicate efficiently in NHBE cells in the presence of oseltamivir or zanamivir and that virus with the H274Y NA substitution has a relative fitness greater than that of the wild-type NAI-susceptible virus.	Sodium Iodide	237-240	neuraminidase 1	Homo sapiens	163-165
26021458-5	2015	Monocarboxylate transporter 8 mRNA and protein levels significantly decreased after 1 day of NaI administration to rats, together with decreased serum T4; while no alteration was observed in LAT2 expression.	Sodium Iodide	93-96	solute carrier family 16 member 2	Rattus norvegicus	0-29
26021458-6	2015	Moreover, both monocarboxylate transporter 8 expression and serum T4 was restored after 6 days of NaI.	Sodium Iodide	98-101	solute carrier family 16 member 2	Rattus norvegicus	15-44
26021458-7	2015	The inhibition of thyroperoxidase activity by methimazole prevented the inhibitory effect of NaI on thyroid monocarboxylate transporter 8 expression, suggesting that an active thyroperoxidase is necessary for MCT8 downregulation by iodine overload, similarly to other thyroid markers, such as sodium iodide symporter.	Sodium Iodide	93-96	solute carrier family 16 member 2	Rattus norvegicus	108-137
26021458-7	2015	The inhibition of thyroperoxidase activity by methimazole prevented the inhibitory effect of NaI on thyroid monocarboxylate transporter 8 expression, suggesting that an active thyroperoxidase is necessary for MCT8 downregulation by iodine overload, similarly to other thyroid markers, such as sodium iodide symporter.	Sodium Iodide	93-96	solute carrier family 16 member 2	Rattus norvegicus	209-213
26770393-1	2015	CONTEXT: As many studies proved that sodium iodide symporter (NIS) plays a key role in radioactive iodide (RAI) therapy of thyroid cancer, however, a growing number of studies suggests that part of differentiated thyroid carcinomas (DTC) with overexpression of NIS are insensitive to RAI well.	Sodium Iodide	37-50	solute carrier family 5 member 5	Homo sapiens	62-65
26770393-1	2015	CONTEXT: As many studies proved that sodium iodide symporter (NIS) plays a key role in radioactive iodide (RAI) therapy of thyroid cancer, however, a growing number of studies suggests that part of differentiated thyroid carcinomas (DTC) with overexpression of NIS are insensitive to RAI well.	Sodium Iodide	37-50	solute carrier family 5 member 5	Homo sapiens	261-264
26194790-3	2015	In this report, we present data that demonstrate the feasibility of using the human sodium iodide symporter (hNIS) as a reporter gene for tracking neural stem cells (NSCs) after transplantation in the brain by using single-photon emission tomography/computed tomography (SPECT/CT) imaging.	Sodium Iodide	84-97	solute carrier family 5 member 5	Homo sapiens	109-113
26379865-2	2015	In this meta-analysis stratified via methylation of sodium iodide symporter promoter, we evaluate the relationship between methylation of sodium iodide symporter promoter and PTC.	Sodium Iodide	52-65	coiled-coil domain containing 6	Homo sapiens	175-178
26379865-2	2015	In this meta-analysis stratified via methylation of sodium iodide symporter promoter, we evaluate the relationship between methylation of sodium iodide symporter promoter and PTC.	Sodium Iodide	138-151	coiled-coil domain containing 6	Homo sapiens	175-178
26379865-7	2015	The prevalence of PTC in patients with methylated sodium iodide symporter promoter was significantly higher than those with non-methylated promoter (OR=7.36, 95% CI: 4.25-12.74, P<0.001).	Sodium Iodide	50-63	coiled-coil domain containing 6	Homo sapiens	18-21
26379865-10	2015	CONCLUSIONS: The methylation of sodium iodide symporter promoter is related with PTC and its aggressive and metastatic potential.	Sodium Iodide	32-45	coiled-coil domain containing 6	Homo sapiens	81-84
25955347-1	2015	Since the sodium/iodide symporter (NIS) stimulates the iodine uptake in normal lactating breast, our study aimed to study the effect of NIS-mediated radioiodide therapy on ER-negative breast cancers.	Sodium Iodide	10-23	solute carrier family 5 member 5	Homo sapiens	35-38
25955347-1	2015	Since the sodium/iodide symporter (NIS) stimulates the iodine uptake in normal lactating breast, our study aimed to study the effect of NIS-mediated radioiodide therapy on ER-negative breast cancers.	Sodium Iodide	10-23	solute carrier family 5 member 5	Homo sapiens	136-139
25673705-2	2015	Neuraminidase (NA) inhibitors (NAIs) are the only class of drugs available to treat influenza A and B virus infections, so the development of NAI-resistant viruses with superior fitness is a public health concern.	Sodium Iodide	31-35	neuraminidase 1	Homo sapiens	0-13