PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
294407-6	1979	The reaction of 17 beta-hydroxysteroid dehydrogenase activity to testectomy and ovariectomy indicates that in the course of several years, during which we have investigated the behaviour of this enzyme in Chbb/THOM rats, the regulation of its activity has changed from one of oestrogen dependency to one of androgen dependency.	Androgens	307-315	aldo-keto reductase family 1, member C12	Rattus norvegicus	16-52
31894360-2	2020	Mostly, PCa progresses to androgen-independent PCa, which has activated AR signaling from androgen-dependent PCa.	Androgens	26-34	androgen receptor	Homo sapiens	72-74
31904529-0	2020	Combined androgen deprivation therapy in recurrent androgen-receptor-positive salivary duct carcinoma - a case report and review of the literature.	Androgens	9-17	androgen receptor	Homo sapiens	51-68
31894360-2	2020	Mostly, PCa progresses to androgen-independent PCa, which has activated AR signaling from androgen-dependent PCa.	Androgens	90-98	androgen receptor	Homo sapiens	72-74
31894360-3	2020	Thus, inhibition of AR signaling may be an important therapeutic target in androgen-dependent and castration-resistant PCa.	Androgens	75-83	androgen receptor	Homo sapiens	20-22
31944172-11	2020	This study shows that sustained high autophagic flux by RUBCN deficiency in PTECs leads to metabolic syndrome concomitantly with an accelerated mobilization of phospholipids from cellular membranes to lysosomes.Abbreviations: ABC: ATP binding cassette; ACADM: acyl-CoA dehydrogenase medium chain; ACTB: actin, beta; ATG: autophagy related; AUC: area under the curve; Baf: bafilomycin A1; BAT: brown adipose tissue; BODIPY: boron-dipyrromethene; BSA: bovine serum albumin; BW: body weight; CAT: chloramphenicol acetyltransferase; CM: complete medium; CPT1A: carnitine palmitoyltransferase 1a, liver; CQ: chloroquine; CTRL: control; EGFP: enhanced green fluorescent protein; CTSD: cathepsin D; EAT: epididymal adipose tissue; EGFR: epidermal growth factor receptor; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1; FA: fatty acid; FBS: fetal bovine serum; GTT: glucose tolerance test; HE: hematoxylin and eosin; HFD: high-fat diet; I/R: ischemia-reperfusion; ITT: insulin tolerance test; KAP: kidney androgen regulated protein; KO: knockout; LAMP1: lysosomal associated membrane protein 1; LD: lipid droplet; LRP2: low density lipoprotein receptor related protein 2; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MAT: mesenteric adipose tissue; MS: mass spectrometry; MTOR: mechanistic target of rapamycin kinase; MTORC1: MTOR complex 1; NDRG1: N-myc downstream regulated 1; NDUFB5: NADH:ubiquinone oxidoreductase subunit B5; NEFA: non-esterified fatty acid; OA: oleic acid; OCT: optimal cutting temperature; ORO: Oil Red O; PAS: Periodic-acid Schiff; PFA: paraformaldehyde; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PPARA: peroxisome proliferator activated receptor alpha; PPARGC1A: PPARG coactivator 1 alpha; PTEC: proximal tubular epithelial cell; RAB7A: RAB7A, member RAS oncogene family; RPS6: ribosomal protein S6; RPS6KB1: ribosomal protein S6 kinase B1; RT: reverse transcription; RUBCN: rubicon autophagy regulator; SAT: subcutaneous adipose tissue; SFC: supercritical fluid chromatography; SQSTM1: sequestosome 1; SREBF1: sterol regulatory element binding transcription factor 1; SV-40: simian virus-40; TFEB: transcription factor EB; TG: triglyceride; TS: tissue specific; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; UN: urea nitrogen; UQCRB: ubiquinol-cytochrome c reductase binding protein; UVRAG: UV radiation resistance associated; VPS: vacuolar protein sorting; WAT: white adipose tissue.	Androgens	1022-1030	RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein	Mus musculus	56-61
32002708-1	2020	Androgen deprivation therapy (ADT) via surgical or chemical castration frequently fails to halt lethal castration-resistant prostate cancer (CRPC), which is induced by multiple mechanisms involving constitutive androgen receptor (AR) splice variants, AR mutation, and/or de novo androgen synthesis.	Androgens	211-219	androgen receptor	Homo sapiens	230-232
32002708-5	2020	QW07 bound to AR-NTD directly, blocked the transactivation of AR-NTD, blocked interactions between co-regulatory proteins and androgen response elements (AREs), inhibited the expression of genes downstream of AR, and inhibited prostate cancer growth in vitro and in vivo.	Androgens	126-134	androgen receptor	Homo sapiens	14-16
32002708-1	2020	Androgen deprivation therapy (ADT) via surgical or chemical castration frequently fails to halt lethal castration-resistant prostate cancer (CRPC), which is induced by multiple mechanisms involving constitutive androgen receptor (AR) splice variants, AR mutation, and/or de novo androgen synthesis.	Androgens	0-8	androgen receptor	Homo sapiens	211-228
32007561-3	2020	Increased CYP17A1 activity in endocrine disorders and diseases are associated with elevated C21 and C19 steroids which include 17alpha-hydroxyprogesterone and androgens, as well as C11-oxy C21 and C11-oxy C19 steroids.	Androgens	159-168	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	10-17
32002708-1	2020	Androgen deprivation therapy (ADT) via surgical or chemical castration frequently fails to halt lethal castration-resistant prostate cancer (CRPC), which is induced by multiple mechanisms involving constitutive androgen receptor (AR) splice variants, AR mutation, and/or de novo androgen synthesis.	Androgens	0-8	androgen receptor	Homo sapiens	230-232
32031713-8	2020	The gene upregulation profile of female apocrine glands included several genes (MRO, DYRK3, SDK2, GLB1L, CATSPERB and PRPS2), which are specifically transcribed during testis differentiation and/or regulated by androgens.	Androgens	211-220	maestro	Homo sapiens	80-83
31857702-4	2020	Here, we report that the deubiquitinating enzyme ubiquitin-specific protease 33 (USP33) inhibits docetaxel-induced apoptosis of prostate cancer cells, including androgen-independent prostate cancer cells.	Androgens	161-169	ubiquitin specific peptidase 33	Homo sapiens	49-79
31857702-4	2020	Here, we report that the deubiquitinating enzyme ubiquitin-specific protease 33 (USP33) inhibits docetaxel-induced apoptosis of prostate cancer cells, including androgen-independent prostate cancer cells.	Androgens	161-169	ubiquitin specific peptidase 33	Homo sapiens	81-86
31745978-1	2020	Androgen deprivation therapy (ADT) is first-line palliative treatment in androgen receptor positive (AR+) salivary duct carcinoma (SDC), and response rates are 17.6-50.0%.	Androgens	0-8	androgen receptor	Homo sapiens	73-90
31745978-1	2020	Androgen deprivation therapy (ADT) is first-line palliative treatment in androgen receptor positive (AR+) salivary duct carcinoma (SDC), and response rates are 17.6-50.0%.	Androgens	0-8	androgen receptor	Homo sapiens	101-103
32007561-12	2020	These findings show that the C11-oxy C21 steroids could potentially contribute to the androgen pool in tissue expressing steroidogenic enzymes in the backdoor pathway.	Androgens	86-94	aldo-keto reductase family 1 member C4	Homo sapiens	29-40
32052578-0	2020	Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion.	Androgens	0-8	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	47-51
32026338-1	2020	PURPOSE: In males, AMH is secreted by immature Sertoli cells; following exposure to endogenous androgens, Sertoli cells undergo a process of maturation which ultimately inhibits AMH expression to undetectable levels in the serum.	Androgens	95-104	anti-Mullerian hormone	Homo sapiens	178-181
32016412-14	2020	CONCLUSIONS: Our findings suggested that HUPCOS mediated androgen excess in follicular fluid of PCOS patients by suppressing aromatase expression via interaction with RBPMS.	Androgens	57-65	RNA binding protein, mRNA processing factor	Homo sapiens	167-172
31772313-8	2020	Moreover, we also elucidated the molecular features of LNCaP-SOX2 cells that may confer resistance to androgen-deprivation therapy (ADT) and the inclination toward neuroendocrine transdifferentiation.	Androgens	102-110	SRY-box transcription factor 2	Homo sapiens	61-65
31972048-4	2020	We observed profound prostate-specific antigen (PSA) and/or objective responses to immune checkpoint blockade following prior treatment with bipolar androgen therapy (BAT) and enzalutamide.	Androgens	149-157	kallikrein related peptidase 3	Homo sapiens	21-52
31805186-0	2020	Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7 expression in castration-resistant prostate cancer.	Androgens	45-53	microRNA 8080	Homo sapiens	15-23
31900930-1	2020	UDP-glucuronosyltransferase 2B17 (UGT2B17) is a highly variable androgen- and drug-metabolizing enzyme.	Androgens	64-72	UDP glucuronosyltransferase family 2 member B17	Homo sapiens	0-32
31900930-1	2020	UDP-glucuronosyltransferase 2B17 (UGT2B17) is a highly variable androgen- and drug-metabolizing enzyme.	Androgens	64-72	UDP glucuronosyltransferase family 2 member B17	Homo sapiens	34-41
32044375-3	2020	We showed that EPPIN is an androgen-dependent gene, expressed in the testis and epididymis, but also present in the vas deferens, seminal vesicle and adrenal gland.	Androgens	27-35	epididymal peptidase inhibitor	Mus musculus	15-20
32039440-0	2020	Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway.	Androgens	59-67	AKT serine/threonine kinase 1	Homo sapiens	172-175
32039440-0	2020	Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway.	Androgens	59-67	mechanistic target of rapamycin kinase	Homo sapiens	176-180
31967940-4	2020	The depletion of SPOP or overexpression of a prostate cancer-associated SPOP mutant, F133V, in androgen receptor-positive prostate cancer cells increased the amount of topoisomerase 2A (TOP2A) in the nuclei together with the increased amount of gammaH2AX, an indication of DNA breaks.	Androgens	95-103	DNA topoisomerase II alpha	Homo sapiens	168-184
31967940-4	2020	The depletion of SPOP or overexpression of a prostate cancer-associated SPOP mutant, F133V, in androgen receptor-positive prostate cancer cells increased the amount of topoisomerase 2A (TOP2A) in the nuclei together with the increased amount of gammaH2AX, an indication of DNA breaks.	Androgens	95-103	DNA topoisomerase II alpha	Homo sapiens	186-191
31969015-2	2020	Pharmacological androgen deprivation includes gonadotropin-releasing hormone agonism and antagonism, AR (androgen receptor) inhibition, and CYP17 inhibition.	Androgens	16-24	gonadotropin releasing hormone 1	Homo sapiens	46-76
31732162-2	2020	Androgen receptor (AR), an important receptor in testicular sertoli cells, is involved in androgen specific response and its dysfunction will lead to abnormal sperm development, resulting in male infertility.	Androgens	90-98	androgen receptor	Capra hircus	0-17
31732162-2	2020	Androgen receptor (AR), an important receptor in testicular sertoli cells, is involved in androgen specific response and its dysfunction will lead to abnormal sperm development, resulting in male infertility.	Androgens	90-98	androgen receptor	Capra hircus	19-21
31969015-2	2020	Pharmacological androgen deprivation includes gonadotropin-releasing hormone agonism and antagonism, AR (androgen receptor) inhibition, and CYP17 inhibition.	Androgens	16-24	androgen receptor	Homo sapiens	101-103
31969015-2	2020	Pharmacological androgen deprivation includes gonadotropin-releasing hormone agonism and antagonism, AR (androgen receptor) inhibition, and CYP17 inhibition.	Androgens	16-24	androgen receptor	Homo sapiens	105-122
31745588-4	2020	Due to the influence of sex on the phenotype, we tested the role of sex hormones, estrogen (beta-estradiol; E2), and androgen (5alpha-dihydroxytestosterone; DHT) in Lgals3-KO mice.	Androgens	117-125	lectin, galactose binding, soluble 3	Mus musculus	165-171
31910029-0	2020	CMKLR1 deficiency attenuates androgen-inducedlipid accumulation in mice.	Androgens	29-37	chemokine-like receptor 1	Mus musculus	0-6
31910029-4	2020	Here, using pharmacological method, orchidectomized model and CMKLR1 knockout mice, we demonstrated that androgen excess in female mice resulted in a larger cell size in white adipose tissue (WAT) and brown adipose tissue (BAT), whereas androgen deprivation of male mice induced a smaller cell size.	Androgens	105-113	chemokine-like receptor 1	Mus musculus	62-68
31910029-6	2020	CMKLR1 deficiency influenced the effect of androgen on adipose tissue by regulating the mRNA expression of androgen receptor (AR) and adipocyte markers (such as Fabp4 and Cidea).	Androgens	43-51	chemokine-like receptor 1	Mus musculus	0-6
31910029-6	2020	CMKLR1 deficiency influenced the effect of androgen on adipose tissue by regulating the mRNA expression of androgen receptor (AR) and adipocyte markers (such as Fabp4 and Cidea).	Androgens	43-51	androgen receptor	Mus musculus	107-124
31732520-7	2020	RESULTS: Evaluation of the patient data demonstrated that CD133 is overexpressed in a specific phenotype of AVPC that is androgen receptor-indifferent and neuroendocrine differentiated.	Androgens	121-129	prominin 1	Homo sapiens	58-63
31910029-6	2020	CMKLR1 deficiency influenced the effect of androgen on adipose tissue by regulating the mRNA expression of androgen receptor (AR) and adipocyte markers (such as Fabp4 and Cidea).	Androgens	43-51	androgen receptor	Mus musculus	126-128
31910029-6	2020	CMKLR1 deficiency influenced the effect of androgen on adipose tissue by regulating the mRNA expression of androgen receptor (AR) and adipocyte markers (such as Fabp4 and Cidea).	Androgens	43-51	fatty acid binding protein 4, adipocyte	Mus musculus	161-166
31910029-6	2020	CMKLR1 deficiency influenced the effect of androgen on adipose tissue by regulating the mRNA expression of androgen receptor (AR) and adipocyte markers (such as Fabp4 and Cidea).	Androgens	43-51	cell death-inducing DNA fragmentation factor, alpha subunit-like effector A	Mus musculus	171-176
31755635-2	2020	A growing body of data suggests an association between androgen deprivation therapy (ADT) and CV/cardiometabolic risk, particularly for GnRH agonists.	Androgens	55-63	gonadotropin releasing hormone 1	Homo sapiens	136-140
31879814-0	2020	Prospective study on the effect of short-term androgen deprivation therapy on PSMA uptake evaluated with 68Ga-PSMA-11 PET/MRI in men with treatment-naive prostate cancer.	Androgens	46-54	folate hydrolase 1	Homo sapiens	78-82
31879814-1	2020	PURPOSE: Based on in vitro studies, it is known that androgen deprivation therapy (ADT) increases prostate-specific membrane antigen (PSMA) expression.	Androgens	53-61	folate hydrolase 1	Homo sapiens	98-132
31879814-1	2020	PURPOSE: Based on in vitro studies, it is known that androgen deprivation therapy (ADT) increases prostate-specific membrane antigen (PSMA) expression.	Androgens	53-61	folate hydrolase 1	Homo sapiens	134-138
31901103-0	2020	New insights in the paradigm of upregulation of tumoral PSMA expression by androgen receptor blockade: Enzalutamide induces PSMA upregulation in castration-resistant prostate cancer even in patients having previously progressed on enzalutamide.	Androgens	75-83	folate hydrolase 1	Homo sapiens	56-60
31901103-1	2020	PURPOSE: There is preliminary evidence for prostate-specific membrane antigen (PSMA) upregulation effects of androgen receptor blockade in prostate cancer.	Androgens	109-117	folate hydrolase 1	Homo sapiens	43-77
31901103-1	2020	PURPOSE: There is preliminary evidence for prostate-specific membrane antigen (PSMA) upregulation effects of androgen receptor blockade in prostate cancer.	Androgens	109-117	folate hydrolase 1	Homo sapiens	79-83
31872382-0	2020	Effect of aberrantly methylated androgen receptor target gene PCDH7 on the development of androgen-independent prostate cancer cells.	Androgens	32-40	protocadherin 7	Homo sapiens	62-67
31991505-5	2020	Our findings suggest that insulin and androgens both are involved in the regulation of PROK1 that could have implications for normal and pathological pregnancies.	Androgens	38-47	prokineticin 1	Homo sapiens	87-92
31925334-4	2020	Here, our genome-wide analyses reveal that BCOR is recruited in an androgen-dependent fashion to majority of AR-binding chromatin sites in castration-resistant prostate cancer (CRPC) cells.	Androgens	67-75	BCL6 corepressor	Homo sapiens	43-47
31925334-4	2020	Here, our genome-wide analyses reveal that BCOR is recruited in an androgen-dependent fashion to majority of AR-binding chromatin sites in castration-resistant prostate cancer (CRPC) cells.	Androgens	67-75	androgen receptor	Homo sapiens	109-111
31925334-5	2020	Interestingly, depletion of BCOR has a significant effect on the expression of androgen-repressed genes linked to regulation of cell proliferation, differentiation and development.	Androgens	79-87	BCL6 corepressor	Homo sapiens	28-32
31838085-0	2020	Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer.	Androgens	0-8	dynamin 1 like	Homo sapiens	31-35
31866547-11	2020	Addition of finasteride or dutasteride to U87 cells reduced androgen and estrogen synthesis.	Androgens	60-68	small nucleolar RNA, C/D box 87	Homo sapiens	42-45
31838085-4	2020	Here, we demonstrate increased levels of dynamin-related protein 1 (DRP1), a mitochondrial fission mediator, in androgen-sensitive and castration-resistant AR-driven PCa.	Androgens	112-120	dynamin 1 like	Homo sapiens	41-66
31838085-4	2020	Here, we demonstrate increased levels of dynamin-related protein 1 (DRP1), a mitochondrial fission mediator, in androgen-sensitive and castration-resistant AR-driven PCa.	Androgens	112-120	dynamin 1 like	Homo sapiens	68-72
31838085-6	2020	DRP1 inhibition activates the cellular metabolic stress response, which involves AMPK phosphorylation, induction of autophagy, and the ER unfolded protein response, and attenuates androgen-induced proliferation.	Androgens	180-188	dynamin 1 like	Homo sapiens	0-4
31820642-3	2020	Depleting androgens by castration dramatically increases the susceptibility of BWF1 male to lupus.	Androgens	10-19	WD repeat and FYVE domain containing 3	Mus musculus	79-83
31821857-5	2020	Mechanistically, these examples call attention to the importance of evolutionary changes in (1) androgen- and estrogen-mediated gene expression, (2) androgen and estrogen receptor expression, and (3) the distribution of androgen and estrogen response elements in target genes throughout the genome.	Androgens	96-104	estrogen receptor 1	Homo sapiens	162-179
32043299-8	2021	Poorly expressed Let-7b and highly expressed NRAS was presented in CRPC tissues and androgen-independent cell line C4-2.	Androgens	84-92	microRNA let7b	Mus musculus	17-23
32043299-8	2021	Poorly expressed Let-7b and highly expressed NRAS was presented in CRPC tissues and androgen-independent cell line C4-2.	Androgens	84-92	neuroblastoma ras oncogene	Mus musculus	45-49
32063492-1	2021	BACKGROUND: Salvage external beam radiotherapy (RT) with androgen deprivation therapy (ADT) improves survival over RT in men with prostate cancer (PC) and rising prostate-specific antigen (PSA) levels after radical prostatectomy (RP).	Androgens	57-65	kallikrein related peptidase 3	Homo sapiens	162-193
31988092-3	2020	Amongst CNH-enriched genes are several that are required for axial elongation, including Wnt3a, Cdx2, Brachyury/T and Fgf8, and androgen/estrogen receptor nuclear signalling components such as Greb1 We show that the pattern and duration of tailbud Greb1 expression is conserved in mouse, zebrafish, and chicken embryos, and that Greb1 is required for axial elongation and somitogenesis in zebrafish embryos.	Androgens	128-136	gene regulated by estrogen in breast cancer protein	Mus musculus	193-198
31988092-3	2020	Amongst CNH-enriched genes are several that are required for axial elongation, including Wnt3a, Cdx2, Brachyury/T and Fgf8, and androgen/estrogen receptor nuclear signalling components such as Greb1 We show that the pattern and duration of tailbud Greb1 expression is conserved in mouse, zebrafish, and chicken embryos, and that Greb1 is required for axial elongation and somitogenesis in zebrafish embryos.	Androgens	128-136	gene regulated by estrogen in breast cancer protein	Mus musculus	248-253
31988092-3	2020	Amongst CNH-enriched genes are several that are required for axial elongation, including Wnt3a, Cdx2, Brachyury/T and Fgf8, and androgen/estrogen receptor nuclear signalling components such as Greb1 We show that the pattern and duration of tailbud Greb1 expression is conserved in mouse, zebrafish, and chicken embryos, and that Greb1 is required for axial elongation and somitogenesis in zebrafish embryos.	Androgens	128-136	growth regulating estrogen receptor binding 1	Gallus gallus	248-253
31760076-0	2020	GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cells.	Androgens	69-77	G protein-coupled receptor 75	Homo sapiens	0-5
31845908-5	2020	Ivermectin potentiated activity of anti-androgen receptor and anti-EGFR drugs in prostate and EGFR/HER2-driven tumor models, respectively, identifying a repurposing approach for cotargeting stress-adaptive responses to overcome resistance to inhibitors of oncogenic pathway signaling.	Androgens	40-48	epidermal growth factor receptor	Homo sapiens	94-98
32019578-0	2020	SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer.	Androgens	48-56	sirtuin 7	Homo sapiens	0-5
31950383-4	2020	RESULTS: We found that AR is more frequently expressed and at higher levels in the ER+PR- subset compared to ER+PR+ tumors.	Androgens	23-25	progesterone receptor	Homo sapiens	86-88
32019578-12	2020	RESULTS: SIRT7 depletion significantly inhibited cell proliferation, androgen-induced autophagy, and invasion in LNCap and 22Rv1 cells (in vitro) and mouse xenograft tumors induced by injection of these cells (in vivo).	Androgens	69-77	sirtuin 7	Homo sapiens	9-14
31950383-4	2020	RESULTS: We found that AR is more frequently expressed and at higher levels in the ER+PR- subset compared to ER+PR+ tumors.	Androgens	23-25	progesterone receptor	Homo sapiens	112-114
31950383-7	2020	CONCLUSION: These data suggest that targeting AR in ER+PR- tumors may represent a promising therapeutic alternative in hormonal refractory tumors.	Androgens	46-48	progesterone receptor	Homo sapiens	55-57
31727674-13	2020	SIGNIFICANCE STATEMENT: The antiandrogen abiraterone (Abi) is a selective steroidal inhibitor of the cytochrome P450 17alpha-hydroxy/17,20-lyase (CYP17A1), an enzyme involved in the biosynthesis of androgens.	Androgens	198-207	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	101-144
31833612-5	2020	Downregulation of MSI2 in both androgen sensitive and insensitive prostate cancer cells inhibited tumor formation in vivo and decreased cell growth in vitro, which could be reversed by AR overexpression.	Androgens	31-39	musashi RNA binding protein 2	Homo sapiens	18-22
31727674-13	2020	SIGNIFICANCE STATEMENT: The antiandrogen abiraterone (Abi) is a selective steroidal inhibitor of the cytochrome P450 17alpha-hydroxy/17,20-lyase (CYP17A1), an enzyme involved in the biosynthesis of androgens.	Androgens	198-207	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	146-153
31604846-10	2020	Likewise, AR knockdown in androgen-dependent cells induced IL-8 expression, further demonstrating that AR represses IL-8 expression.	Androgens	26-34	androgen receptor	Homo sapiens	10-12
31894239-2	2020	The aldo-keto reductase AKR1C3 regulates androgen receptor (AR) activity in castration-resistant prostate cancer (CRPC) by promoting tumor-tissue androgen biosynthesis from adrenal DHEA and also by functioning as an AR-selective coactivator.	Androgens	41-49	aldo-keto reductase family 1 member C3	Homo sapiens	24-30
31894239-2	2020	The aldo-keto reductase AKR1C3 regulates androgen receptor (AR) activity in castration-resistant prostate cancer (CRPC) by promoting tumor-tissue androgen biosynthesis from adrenal DHEA and also by functioning as an AR-selective coactivator.	Androgens	41-49	androgen receptor	Homo sapiens	60-62
31894239-2	2020	The aldo-keto reductase AKR1C3 regulates androgen receptor (AR) activity in castration-resistant prostate cancer (CRPC) by promoting tumor-tissue androgen biosynthesis from adrenal DHEA and also by functioning as an AR-selective coactivator.	Androgens	41-49	androgen receptor	Homo sapiens	216-218
31626910-14	2020	The study highlights the contribution of adrenal C11-oxy steroids to the androgen pool in BPH underscoring their limited reactivation and elimination, and significant inter-individual variations regarding steroid levels and conjugation.	Androgens	73-81	aldo-keto reductase family 1 member C4	Homo sapiens	49-52
31669572-1	2020	Aromatase (CYP19A1) converts androgens into estrogens and is required for female sexual development and growth and development in both sexes.	Androgens	29-38	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	11-18
31799745-13	2020	Acquired cabazitaxel resistance involving overexpression of efflux transporter ABCB1 can be reverted by bicalutamide or enzalutamide treatment, indicating the great clinical potential for combined treatment with cabazitaxel and anti-androgens.	Androgens	233-242	ATP binding cassette subfamily B member 1	Homo sapiens	79-84
31797736-3	2020	Our recent study demonstrated a novel regulatory pattern of androgen in regulation of spermatogonia differentiation, which is androgen indirectly regulates the expression of ITGB1 on Sertoli Cells via intermediate molecule Wilms tumor-1 (Wt-1) during spermatogenesis.	Androgens	60-68	WT1 transcription factor	Homo sapiens	223-236
31797736-3	2020	Our recent study demonstrated a novel regulatory pattern of androgen in regulation of spermatogonia differentiation, which is androgen indirectly regulates the expression of ITGB1 on Sertoli Cells via intermediate molecule Wilms tumor-1 (Wt-1) during spermatogenesis.	Androgens	126-134	integrin subunit beta 1	Homo sapiens	174-179
31797736-3	2020	Our recent study demonstrated a novel regulatory pattern of androgen in regulation of spermatogonia differentiation, which is androgen indirectly regulates the expression of ITGB1 on Sertoli Cells via intermediate molecule Wilms tumor-1 (Wt-1) during spermatogenesis.	Androgens	126-134	WT1 transcription factor	Homo sapiens	223-236
31797736-4	2020	In this study, we identified that Connexin 43 (Cx43), the key component for gap junction distributed between spermatogonia and Sertoli cells, was also regulated by androgen signal.	Androgens	164-172	gap junction protein alpha 1	Homo sapiens	34-45
31797736-4	2020	In this study, we identified that Connexin 43 (Cx43), the key component for gap junction distributed between spermatogonia and Sertoli cells, was also regulated by androgen signal.	Androgens	164-172	gap junction protein alpha 1	Homo sapiens	47-51
31797736-6	2020	Finally, we revealed a regulatory pattern of Cx43 by androgen in Sertoli cells, and the Sertoli cells in germ cell depleted microenvironment were sensitive to androgen signal, which enhances the understanding of the mechanism of spermatogenesis.	Androgens	53-61	gap junction protein alpha 1	Homo sapiens	45-49
31852737-8	2020	Both DVT and IPI increased the activity of testosterone in a cell culture androgen reporter system by competitively displacing testosterone from SHBG.	Androgens	74-82	sex hormone binding globulin	Homo sapiens	145-149
32064040-6	2020	The expression of PMEPA1-e was induced by androgen and AR.	Androgens	42-50	prostate transmembrane protein, androgen induced 1	Homo sapiens	18-24
32064040-8	2020	Both PMEPA1-d and PMPEA1-e promoted the growth of androgen independent prostate cancer cells.	Androgens	50-58	prostate transmembrane protein, androgen induced 1	Homo sapiens	5-11
31953400-3	2020	Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cells suppresses androgen receptor (AR) axis signaling and induces the neural BRN2 transcription factor.	Androgens	52-60	mucin 1, cell surface associated	Homo sapiens	42-46
31953400-3	2020	Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cells suppresses androgen receptor (AR) axis signaling and induces the neural BRN2 transcription factor.	Androgens	52-60	androgen receptor	Homo sapiens	91-108
31953400-3	2020	Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cells suppresses androgen receptor (AR) axis signaling and induces the neural BRN2 transcription factor.	Androgens	52-60	androgen receptor	Homo sapiens	110-112
31940946-1	2020	Androgen receptor (AR) signaling is fundamental to prostate cancer (PC) progression, and hence, androgen deprivation therapy (ADT) remains a mainstay of treatment.	Androgens	96-104	androgen receptor	Homo sapiens	19-21
31901895-5	2020	In the androgen-sensitive cell lines, AR knockdown attenuated sensitivity to the LSD1 inhibitor but not the JQ1 inhibitor.	Androgens	7-15	androgen receptor	Homo sapiens	38-40
31901895-5	2020	In the androgen-sensitive cell lines, AR knockdown attenuated sensitivity to the LSD1 inhibitor but not the JQ1 inhibitor.	Androgens	7-15	lysine demethylase 1A	Homo sapiens	81-85
31736422-10	2020	In summary, miR-133a-5p inhibits AR-positive prostate cancer cell proliferation by targeting FUS/AR, thus improving the resistance of prostate cancer to androgen ablation therapies, which requires further in vivo validation.	Androgens	153-161	androgen receptor	Homo sapiens	33-35
31778359-1	2020	Advanced prostate cancer is often treated with anti-androgens which target the androgen receptor (AR) on which the growth of the tumour depends.	Androgens	52-61	androgen receptor	Homo sapiens	79-96
31778359-1	2020	Advanced prostate cancer is often treated with anti-androgens which target the androgen receptor (AR) on which the growth of the tumour depends.	Androgens	52-61	androgen receptor	Homo sapiens	98-100
31778359-4	2020	In these resistant cells, we observed, via RNA-seq, that new variants in the 3"UTR of the AR mRNA were detectable and that the levels were increased both with anti-androgen treatment and with hormonal starvation.	Androgens	164-172	androgen receptor	Homo sapiens	90-92
31778359-8	2020	We hypothesise that the shorter AR UTR variant is a survival adaptation to low hormone levels and/or anti-androgen treatment in these cells, where a more stable mRNA may allow higher levels of AR expression under these conditions.	Androgens	106-114	androgen receptor	Homo sapiens	32-34
31875912-0	2020	Ovarian androgens maintain high GnRH neuron firing rate in adult prenatally androgenized female mice.	Androgens	8-17	gonadotropin releasing hormone 1	Mus musculus	32-36
31875912-11	2020	These results suggest prenatal androgen exposure programs marked changes in GnRH neuron regulation by homeostatic steroid feedback.	Androgens	31-39	gonadotropin releasing hormone 1	Mus musculus	76-80
31786088-1	2020	Aromatase is the requisite and limiting enzyme in the production of estrogens from androgens.	Androgens	83-92	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
31820173-6	2020	Both estrogen and androgen exert their effects via the estrogen receptor (ER) or the androgen receptor (AR), which belongs to the nuclear receptor superfamily.	Androgens	18-26	estrogen receptor 1	Homo sapiens	55-72
31820173-6	2020	Both estrogen and androgen exert their effects via the estrogen receptor (ER) or the androgen receptor (AR), which belongs to the nuclear receptor superfamily.	Androgens	18-26	estrogen receptor 1	Homo sapiens	74-76
31820173-6	2020	Both estrogen and androgen exert their effects via the estrogen receptor (ER) or the androgen receptor (AR), which belongs to the nuclear receptor superfamily.	Androgens	18-26	androgen receptor	Homo sapiens	85-102
31820173-6	2020	Both estrogen and androgen exert their effects via the estrogen receptor (ER) or the androgen receptor (AR), which belongs to the nuclear receptor superfamily.	Androgens	18-26	androgen receptor	Homo sapiens	104-106
31600720-7	2020	Androgens also decreased testicular PGE2 production, increased the transcript levels of the enzyme catabolizing PGs and decreased PGE2 receptor ptger4b transcript levels.	Androgens	0-9	prostaglandin E receptor 4 (subtype EP4) b	Danio rerio	144-151
31600720-9	2020	Taken together, our results indicate that PGE2, via Ep4 receptors, favors self-renewal in conjunction with androgens and, independent of Fsh and androgens, inhibits differentiating divisions of spermatogonia.	Androgens	107-116	prostaglandin E receptor 4 (subtype EP4) a	Danio rerio	52-55
31548294-1	2020	The second-generation anti-androgen, enzalutamide (ENZ), is approved for castrate-resistant (CR) PC and targets androgen receptor (AR) activity in CRPC.	Androgens	27-35	androgen receptor	Homo sapiens	112-129
31548294-1	2020	The second-generation anti-androgen, enzalutamide (ENZ), is approved for castrate-resistant (CR) PC and targets androgen receptor (AR) activity in CRPC.	Androgens	27-35	androgen receptor	Homo sapiens	131-133
31804970-0	2020	Androgen modulation of XBP1 is functionally driving part of the AR transcriptional program.	Androgens	0-8	X-box binding protein 1	Homo sapiens	23-27
31804970-0	2020	Androgen modulation of XBP1 is functionally driving part of the AR transcriptional program.	Androgens	0-8	androgen receptor	Homo sapiens	64-66
31804970-9	2020	Transcriptomic effects of XBP1 were further studied by knockdown experiments, which lead to decreased expression of androgen-responsive genes and UPR genes.	Androgens	116-124	X-box binding protein 1	Homo sapiens	26-30
31804970-10	2020	These results suggest a two-step mechanism of gene regulation, which involves androgen-induced expression of ERN1, thereby enhancing XBP1 splicing and transcriptional activity.	Androgens	78-86	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	109-113
31804970-10	2020	These results suggest a two-step mechanism of gene regulation, which involves androgen-induced expression of ERN1, thereby enhancing XBP1 splicing and transcriptional activity.	Androgens	78-86	X-box binding protein 1	Homo sapiens	133-137
31815681-0	2020	A lex naturalis delineates components of a human-specific, adrenal androgen-dependent, p53-mediated "kill switch" tumor suppression mechanism.	Androgens	67-75	tumor protein p53	Homo sapiens	87-90
31815681-1	2020	We have recently described in this journal our detection of an anthropoid primate-specific, adrenal androgen-dependent, p53-mediated, "kill switch" tumor suppression mechanism that reached its fullest expression only in humans, as a result of human-specific exposure to polycyclic aromatic hydrocarbons caused by the harnessing of fire.	Androgens	100-108	tumor protein p53	Homo sapiens	120-123
31894265-0	2020	Ophiopogonin D" induces RIPK1-dependent necroptosis in androgen-dependent LNCaP prostate cancer cells.	Androgens	55-63	receptor interacting serine/threonine kinase 1	Homo sapiens	24-29
31894265-3	2020	In the present study, OPD" induced significant necroptosis in androgen-dependent LNCaP cancer cells by activating receptor-interacting serine/threonine-protein kinase 1 (RIPK1).	Androgens	62-70	receptor interacting serine/threonine kinase 1	Homo sapiens	114-168
31894265-3	2020	In the present study, OPD" induced significant necroptosis in androgen-dependent LNCaP cancer cells by activating receptor-interacting serine/threonine-protein kinase 1 (RIPK1).	Androgens	62-70	receptor interacting serine/threonine kinase 1	Homo sapiens	170-175
31810878-0	2020	Androgen receptor expression in preputial dartos tissue correlates with physiological androgen exposure in congenital malformations of the penis and in controls.	Androgens	86-94	androgen receptor	Homo sapiens	0-17
31810878-1	2020	INTRODUCTION: The androgen receptor (AR) plays an important role in the development of male genitalia, and impaired androgen signalling has been hypothesised to underlie congenital penile malformations (CPM) such as hypospadias.	Androgens	18-26	androgen receptor	Homo sapiens	37-39
31810878-12	2020	In this study, AR expression in human foreskin shows a bimodal distribution in boys with CMP and controls, following physiological androgen exposure.	Androgens	131-139	androgen receptor	Homo sapiens	15-17
31614207-7	2020	Depending on the incubation time with HSD17B3-expressing cells, the culture media progressively increased luciferase activities in CV-1 cells, transfected with the AR expression vector and androgen-responsive reporter.	Androgens	189-197	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	38-45
31626910-3	2020	However, the adrenal C11-oxy C19 steroid, 11beta-hydroxyandrostenedione (11OHA4), also contributes to the active androgen pool in the prostate microenvironment, and while it has been shown to impact castration resistant prostate cancer, the C11-oxy C19 steroids together with the C11-oxy C21 steroids have not been studied in BPH.	Androgens	113-121	aldo-keto reductase family 1 member C4	Homo sapiens	21-24
31626910-5	2020	Comprehensive profiles identified 11keto-testosterone as the predominant active androgen in the metabolism of the C11-oxy C19 steroids, and we identified, for the first time, 11beta-hydroxy-5alpha-androstane-3alpha,17beta-diol, a novel steroid in the 11OHA4-pathway.	Androgens	80-88	aldo-keto reductase family 1 member C4	Homo sapiens	114-117
31896509-3	2020	Androgen receptor (AR) activated by DHEA or other types of androgen was reported to promote drug resistance in prostate cancer.	Androgens	59-67	androgen receptor	Mus musculus	0-17
31896509-3	2020	Androgen receptor (AR) activated by DHEA or other types of androgen was reported to promote drug resistance in prostate cancer.	Androgens	59-67	androgen receptor	Mus musculus	19-21
31797736-0	2020	Androgen Indirectly Regulates Gap Junction Component Connexin 43 via Wilms Tumor-1 in Sertoli Cells.	Androgens	0-8	gap junction protein alpha 1	Homo sapiens	53-64
31797736-0	2020	Androgen Indirectly Regulates Gap Junction Component Connexin 43 via Wilms Tumor-1 in Sertoli Cells.	Androgens	0-8	WT1 transcription factor	Homo sapiens	69-82
31797736-3	2020	Our recent study demonstrated a novel regulatory pattern of androgen in regulation of spermatogonia differentiation, which is androgen indirectly regulates the expression of ITGB1 on Sertoli Cells via intermediate molecule Wilms tumor-1 (Wt-1) during spermatogenesis.	Androgens	60-68	integrin subunit beta 1	Homo sapiens	174-179
31629071-2	2020	Hs578t cells expressed aromatase (CYP19) mainly via the healthy stromal CYP19 promoter I.4, but also to a lesser extent via the breast cancer-relevant promoters PII, I.3 and I.7, and produced estrogens from androgen precursors.	Androgens	207-215	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	34-39
31852737-0	2020	Molecular interactions between sex hormone-binding globulin and non-steroidal ligands that enhance androgen action.	Androgens	99-107	sex hormone binding globulin	Homo sapiens	31-59
31852737-1	2020	Sex hormone-binding globulin (SHBG) determines the equilibrium between free and protein-bound androgens and estrogens in the blood and regulates their access to target tissues.	Androgens	94-103	sex hormone binding globulin	Homo sapiens	0-28
31852737-1	2020	Sex hormone-binding globulin (SHBG) determines the equilibrium between free and protein-bound androgens and estrogens in the blood and regulates their access to target tissues.	Androgens	94-103	sex hormone binding globulin	Homo sapiens	30-34
31852737-2	2020	Using crystallographic approaches and radiolabeled competitive binding-capacity assays, we report here how two non-steroidal compounds bind to human SHBG, and how they influence androgen activity in cell culture.	Androgens	178-186	sex hormone binding globulin	Homo sapiens	149-153
31829580-5	2020	Transcriptional expression of most genes in different mixtures was steroid-specific with the exception of genes encoding aromatase (cyp19b), sulfatase (sult2st3) and cyp2k22 that were induced by androgens, progestins and glucocorticoids.	Androgens	195-204	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	121-130
31829580-5	2020	Transcriptional expression of most genes in different mixtures was steroid-specific with the exception of genes encoding aromatase (cyp19b), sulfatase (sult2st3) and cyp2k22 that were induced by androgens, progestins and glucocorticoids.	Androgens	195-204	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	132-138
31829580-5	2020	Transcriptional expression of most genes in different mixtures was steroid-specific with the exception of genes encoding aromatase (cyp19b), sulfatase (sult2st3) and cyp2k22 that were induced by androgens, progestins and glucocorticoids.	Androgens	195-204	sulfotransferase family 2, cytosolic sulfotransferase 3	Danio rerio	152-160
31829580-5	2020	Transcriptional expression of most genes in different mixtures was steroid-specific with the exception of genes encoding aromatase (cyp19b), sulfatase (sult2st3) and cyp2k22 that were induced by androgens, progestins and glucocorticoids.	Androgens	195-204	cytochrome P450, family 2, subfamily K, polypeptide 22	Danio rerio	166-173
31959826-0	2020	Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer.	Androgens	0-8	serine peptidase inhibitor Kazal type 1	Homo sapiens	33-39
31959826-1	2020	Emergence of an aggressive androgen receptor (AR)-independent neuroendocrine prostate cancer (NEPC) after androgen-deprivation therapy (ADT) is well-known.	Androgens	27-35	androgen receptor	Homo sapiens	46-48
31963729-7	2020	In xenografts exposed continuously to hCG, we demonstrate the maintenance of Leydig cell steroidogenesis, the acquisition of features of Sertoli cell maturation (androgen receptor, lumen development), and the formation of the blood-testis barrier (connexin 43), none of which were present prior to the transplantation or in xenografts in which hCG was withdrawn after 7 months.	Androgens	162-170	hypertrichosis 2 (generalised, congenital)	Homo sapiens	38-41
31753699-1	2020	5alpha-Dihydrotestosterone (5alpha-DHT) possesses a great affinity for the androgen receptor (AR), and its binding to AR promotes the proliferation of prostate cancer (PC) cells in androgen-dependent PC.	Androgens	75-83	androgen receptor	Homo sapiens	94-96
31669651-10	2020	The expression of npr and ar induced by LH/hCG was also blocked, which further suppressed the signaling of progestin and androgen.	Androgens	121-129	hypertrichosis 2 (generalised, congenital)	Homo sapiens	43-46
31929563-0	2020	Loss of androgen signaling in mesenchymal sonic hedgehog responsive cells diminishes prostate development, growth, and regeneration.	Androgens	8-16	sonic hedgehog signaling molecule	Homo sapiens	42-56
31929563-7	2020	Prepubescent deletion of AR expression in Gli1-expressing cells resulted in severe impairment of androgen-induced prostate growth and regeneration.	Androgens	97-105	androgen receptor	Homo sapiens	25-27
31929563-7	2020	Prepubescent deletion of AR expression in Gli1-expressing cells resulted in severe impairment of androgen-induced prostate growth and regeneration.	Androgens	97-105	GLI family zinc finger 1	Homo sapiens	42-46
31929563-11	2020	These data demonstrate a novel role of the AR in the Gli1-expressing cellular niche for regulating prostatic cell fate, morphogenesis, and renewal, and elucidate the mechanism by which mesenchymal androgen-signaling through SHH-responsive cells elicits the growth and regeneration of prostate epithelium.	Androgens	197-205	androgen receptor	Homo sapiens	43-45
31929563-11	2020	These data demonstrate a novel role of the AR in the Gli1-expressing cellular niche for regulating prostatic cell fate, morphogenesis, and renewal, and elucidate the mechanism by which mesenchymal androgen-signaling through SHH-responsive cells elicits the growth and regeneration of prostate epithelium.	Androgens	197-205	GLI family zinc finger 1	Homo sapiens	53-57
31929563-11	2020	These data demonstrate a novel role of the AR in the Gli1-expressing cellular niche for regulating prostatic cell fate, morphogenesis, and renewal, and elucidate the mechanism by which mesenchymal androgen-signaling through SHH-responsive cells elicits the growth and regeneration of prostate epithelium.	Androgens	197-205	sonic hedgehog signaling molecule	Homo sapiens	224-227
31940946-9	2020	The anti-oxidant N-acetyl cysteine (NAC) could overcome this AR-suppressive effect of CDDO-Me. Co-exposure of PC cells to CDDO-Me enhanced the efficacy of a clinically approved anti-androgen, enzalutamide (ENZ), as evident by decreased cell-viability along with migration and colony forming ability of PC cells.	Androgens	182-190	androgen receptor	Homo sapiens	61-63
31712062-3	2020	Androgens play an important role in different disorders, therefore, androgen receptor signalling is a crucial factor in pathological conditions.	Androgens	0-9	androgen receptor	Homo sapiens	68-85
31715352-4	2020	Like natural androgens, such as TST and 5alpha-dihydrotestosterone (5alpha-DHT), STZ binds androgen receptor (AR) to activate AR-mediated signalling.	Androgens	13-22	thiosulfate sulfurtransferase	Homo sapiens	32-35
31715352-4	2020	Like natural androgens, such as TST and 5alpha-dihydrotestosterone (5alpha-DHT), STZ binds androgen receptor (AR) to activate AR-mediated signalling.	Androgens	13-22	androgen receptor	Homo sapiens	91-108
31715352-4	2020	Like natural androgens, such as TST and 5alpha-dihydrotestosterone (5alpha-DHT), STZ binds androgen receptor (AR) to activate AR-mediated signalling.	Androgens	13-22	androgen receptor	Homo sapiens	110-112
31715352-4	2020	Like natural androgens, such as TST and 5alpha-dihydrotestosterone (5alpha-DHT), STZ binds androgen receptor (AR) to activate AR-mediated signalling.	Androgens	13-22	androgen receptor	Homo sapiens	126-128
31885322-7	2020	This review focuses on these aspects of cyclin D1 pathophysiology, which may be crucial for targeted therapy.Abbreviations: aa, amino acid; AR, androgen receptor; ATM, ataxia telangectasia mutant; ATR, ATM and Rad3-related; CDK, cyclin-dependent kinase; ChREBP, carbohydrate response element binding protein; CIP, CDK-interacting protein; CHK1/2, checkpoint kinase 1/2; CKI, CDK inhibitor; DDR, DNA damage response; DMP1, cyclin D-binding myb-like protein; DSB, double-strand DNA break; DNA-PK, DNA-dependent protein kinase; ER, estrogen receptor; FASN, fatty acid synthase; GSK3beta, glycogen synthase-3beta; HAT, histone acetyltransferase; HDAC, histone deacetylase; HK2, hexokinase 2; HNF4alpha, and hepatocyte nuclear factor 4alpha; HR, homologous recombination; IR, ionizing radiation; KIP, kinase inhibitory protein; MCL, mantle cell lymphoma; NHEJ, non-homologous end-joining; PCAF, p300/CREB binding-associated protein; PGC1alpha, PPARgamma co-activator 1alpha; PEST, proline-glutamic acid-serine-threonine, PK, pyruvate kinase; PPAR, peroxisome proliferator-activated receptor; RB1, retinoblastoma protein; ROS, reactive oxygen species; SRC, steroid receptor coactivator; STAT, signal transducer and activator of transcription; TGFbeta, transforming growth factor beta; UPS, ubiquitin-proteasome system; USP22, ubiquitin-specific peptidase 22; XPO1 (or CRM1) exportin 1.	Androgens	144-152	cyclin D1	Mus musculus	40-49
32072894-2	2020	Inhibition of CBP has therefore been discovered to be an important therapeutic option in androgen receptor signalling pathway mediated prostate cancer.	Androgens	89-97	CREB binding protein	Homo sapiens	14-17
31604846-10	2020	Likewise, AR knockdown in androgen-dependent cells induced IL-8 expression, further demonstrating that AR represses IL-8 expression.	Androgens	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
31604846-10	2020	Likewise, AR knockdown in androgen-dependent cells induced IL-8 expression, further demonstrating that AR represses IL-8 expression.	Androgens	26-34	androgen receptor	Homo sapiens	103-105
31604846-10	2020	Likewise, AR knockdown in androgen-dependent cells induced IL-8 expression, further demonstrating that AR represses IL-8 expression.	Androgens	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
31734054-10	2020	HIF-1alpha expression in the stroma was also significantly correlated with higher expressions of the androgen and progesterone receptors in the stroma.	Androgens	101-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
31855178-3	2019	Genes differentially expressed upon TLE3 loss share AR as the top transcriptional regulator, and TLE3 loss rescued the expression of a subset of androgen-responsive genes upon enzalutamide treatment.	Androgens	145-153	TLE family member 3, transcriptional corepressor	Homo sapiens	36-40
31556849-6	2020	Recently, accumulating data indicates that the abnormal expression and function of SLCO1B3 are involved in resistance to anticancer drugs, such as taxanes, camptothecin and its analogs, SN-38, and androgen deprivation therapy (ADT) in breast, prostate, lung, hepatic, and colorectal cancer, respectively.	Androgens	197-205	solute carrier organic anion transporter family member 1B3	Homo sapiens	83-90
31874971-0	2019	"Free" inhibin alpha subunit is expressed by bovine ovarian theca cells and its knockdown suppresses androgen production.	Androgens	101-109	inhibin subunit alpha	Bos taurus	7-28
31874971-6	2019	In vitro, knockdown of thecal INHA inhibited INSL3 and CYP17A1 expression and androgen production while INSL3 knockdown reduced INHA and inhibin alpha secretion.	Androgens	78-86	inhibin subunit alpha	Bos taurus	30-34
31874971-7	2019	These findings suggest a positive role of thecal inhibin alpha on androgen production.	Androgens	66-74	inhibin subunit alpha	Bos taurus	49-62
31874971-9	2019	We hypothesised that inhibin alpha may modulate the opposing effects of BMP and inhibin on androgen production.	Androgens	91-99	inhibin subunit alpha	Bos taurus	21-34
31874971-11	2019	Furthermore, neither circulating nor intrafollicular androgen concentrations differed between control and inhibin alpha-immunized heifers, casting further doubt on thecal inhibin alpha subunit having a significant role in modulating androgen production.	Androgens	233-241	inhibin subunit alpha	Bos taurus	171-184
32046386-5	2020	To test if androgen-programmed changes in SF1, DAX1, and FOXO3 proteins contribute to follicular defects in prenatal T-treated sheep, ovaries from control, prenatal T-, and dihydrotestosterone (DHT)-treated (days 30-90 of gestation) animals at fetal day (FD) 90, FD140, and 1 and 2 years-of-age were studied.	Androgens	11-19	steroidogenic factor 1	Ovis aries	42-45
32046386-5	2020	To test if androgen-programmed changes in SF1, DAX1, and FOXO3 proteins contribute to follicular defects in prenatal T-treated sheep, ovaries from control, prenatal T-, and dihydrotestosterone (DHT)-treated (days 30-90 of gestation) animals at fetal day (FD) 90, FD140, and 1 and 2 years-of-age were studied.	Androgens	11-19	nuclear receptor subfamily 0 group B member 1	Homo sapiens	47-51
32046386-5	2020	To test if androgen-programmed changes in SF1, DAX1, and FOXO3 proteins contribute to follicular defects in prenatal T-treated sheep, ovaries from control, prenatal T-, and dihydrotestosterone (DHT)-treated (days 30-90 of gestation) animals at fetal day (FD) 90, FD140, and 1 and 2 years-of-age were studied.	Androgens	11-19	forkhead box protein O3	Ovis aries	57-62
32046386-9	2020	These age-dependent changes in DAX1/SF1 partly via androgen-programming are consistent with changes in AMH and may contribute to the enhanced follicular recruitment/persistence, and multifollicular phenotype of prenatal T-treated females and may be of translational relevance to PCOS.	Androgens	51-59	nuclear receptor subfamily 0 group B member 1	Homo sapiens	31-35
32046386-9	2020	These age-dependent changes in DAX1/SF1 partly via androgen-programming are consistent with changes in AMH and may contribute to the enhanced follicular recruitment/persistence, and multifollicular phenotype of prenatal T-treated females and may be of translational relevance to PCOS.	Androgens	51-59	steroidogenic factor 1	Ovis aries	36-39
31877956-4	2019	Over the years, multiple approaches have been evaluated to effectively target the androgen signaling pathway that include direct targeting of the androgens, androgen receptor (AR), AR co-regulators or other alternate mechanisms that impact the outcome of androgen signaling.	Androgens	82-90	androgen receptor	Homo sapiens	157-174
31877956-4	2019	Over the years, multiple approaches have been evaluated to effectively target the androgen signaling pathway that include direct targeting of the androgens, androgen receptor (AR), AR co-regulators or other alternate mechanisms that impact the outcome of androgen signaling.	Androgens	82-90	androgen receptor	Homo sapiens	176-178
31877956-4	2019	Over the years, multiple approaches have been evaluated to effectively target the androgen signaling pathway that include direct targeting of the androgens, androgen receptor (AR), AR co-regulators or other alternate mechanisms that impact the outcome of androgen signaling.	Androgens	82-90	androgen receptor	Homo sapiens	181-183
31861570-10	2019	In conclusion, neonatal exposure to either agonist or antagonist of androgen receptor affected AMH and FSH signalling systems in preantral follicles.	Androgens	68-76	muellerian-inhibiting factor	Sus scrofa	95-98
31855178-3	2019	Genes differentially expressed upon TLE3 loss share AR as the top transcriptional regulator, and TLE3 loss rescued the expression of a subset of androgen-responsive genes upon enzalutamide treatment.	Androgens	145-153	androgen receptor	Homo sapiens	52-54
31855178-3	2019	Genes differentially expressed upon TLE3 loss share AR as the top transcriptional regulator, and TLE3 loss rescued the expression of a subset of androgen-responsive genes upon enzalutamide treatment.	Androgens	145-153	TLE family member 3, transcriptional corepressor	Homo sapiens	97-101
31934548-1	2020	I report a case of multiple organ failure (acute kidney injury, interstitial pneumonitis and liver dysfunction) associated with combined androgen blockade(CAB) with bicalutamide and leuprorelin acetate for prostate cancer that was successfully managed by prompt hemodialysis and withdrawal of medications.	Androgens	137-145	neural proliferation, differentiation and control 1	Homo sapiens	155-158
31908413-7	2019	The acquisition of androgen-independent condition is consistent with an induction of beta-III Tubulin and gamma Enolase, both markers of neuroendocrine phenotype.	Androgens	19-27	enolase 2	Homo sapiens	106-119
31861264-2	2019	Both AR and GR have a role in resistance to androgen deprivation therapy (ADT), the mainstay of treatment for late stage prostate cancer.	Androgens	44-52	androgen receptor	Homo sapiens	5-7
31861264-2	2019	Both AR and GR have a role in resistance to androgen deprivation therapy (ADT), the mainstay of treatment for late stage prostate cancer.	Androgens	44-52	nuclear receptor subfamily 3 group C member 1	Homo sapiens	12-14
31842336-7	2019	Importantly, TGF-beta signaling and microRNA-mediated regulation of gene expression often act in complicated feedback circuits that involve other crucial regulators of cancer progression (e.g., androgen receptor).	Androgens	194-202	transforming growth factor beta 1	Homo sapiens	13-21
31861264-8	2019	These results show that PlexinB1 activation has a role in the trafficking and activation of the nuclear receptor GR and thus may have a role in resistance to androgen deprivation therapy in late stage prostate cancer.	Androgens	158-166	plexin B1	Homo sapiens	24-32
31861264-8	2019	These results show that PlexinB1 activation has a role in the trafficking and activation of the nuclear receptor GR and thus may have a role in resistance to androgen deprivation therapy in late stage prostate cancer.	Androgens	158-166	nuclear receptor subfamily 3 group C member 1	Homo sapiens	113-115
31647098-0	2019	Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation.	Androgens	75-83	lysine demethylase 4B	Homo sapiens	27-32
31836808-0	2019	hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen.	Androgens	125-133	achaete-scute family bHLH transcription factor 1	Homo sapiens	0-5
31836808-2	2019	Cell fate regulator ASCL1/hASH1"s expression was markedly induced in androgen deprived (AD) LNCaP cells and prominent nuclear localisation accompanied acquisition of the NE-like morphology and expression of NE markers (NSE).	Androgens	69-77	achaete-scute family bHLH transcription factor 1	Homo sapiens	20-25
31836808-2	2019	Cell fate regulator ASCL1/hASH1"s expression was markedly induced in androgen deprived (AD) LNCaP cells and prominent nuclear localisation accompanied acquisition of the NE-like morphology and expression of NE markers (NSE).	Androgens	69-77	achaete-scute family bHLH transcription factor 1	Homo sapiens	26-31
31836808-3	2019	By contrast, androgen-insensitive PC3 and DU145 cells displayed clear nuclear hASH1 localisation under control conditions that was unchanged by AD, suggesting AR signalling negatively regulated hASH1 expression and localisation.	Androgens	13-21	achaete-scute family bHLH transcription factor 1	Homo sapiens	78-83
31836808-3	2019	By contrast, androgen-insensitive PC3 and DU145 cells displayed clear nuclear hASH1 localisation under control conditions that was unchanged by AD, suggesting AR signalling negatively regulated hASH1 expression and localisation.	Androgens	13-21	achaete-scute family bHLH transcription factor 1	Homo sapiens	194-199
31836808-4	2019	Synthetic androgen (R1881) prevented NE transdifferentiation of AD LNCaP cells and markedly suppressed expression of key regulators of lineage commitment and neurogenesis (REST and ASCL1/hASH1).	Androgens	10-18	achaete-scute family bHLH transcription factor 1	Homo sapiens	181-186
31836808-4	2019	Synthetic androgen (R1881) prevented NE transdifferentiation of AD LNCaP cells and markedly suppressed expression of key regulators of lineage commitment and neurogenesis (REST and ASCL1/hASH1).	Androgens	10-18	achaete-scute family bHLH transcription factor 1	Homo sapiens	187-192
31929813-1	2019	Aromatase, a cytochrome P450 enzyme that converts androgens into estrogens, is an important drug target for hormone-dependent diseases.	Androgens	50-59	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
31842254-0	2019	Analysis of PMEPA1 Isoforms (a and b) as Selective Inhibitors of Androgen and TGF-beta Signaling Reveals Distinct Biological and Prognostic Features in Prostate Cancer.	Androgens	65-73	prostate transmembrane protein, androgen induced 1	Homo sapiens	12-18
31842254-2	2019	Prostate Transmembrane Protein Androgen Induced 1 (PMEPA1) inhibits androgen and TGF-beta signaling via a negative feedback loop.	Androgens	68-76	prostate transmembrane protein, androgen induced 1	Homo sapiens	0-49
31842254-2	2019	Prostate Transmembrane Protein Androgen Induced 1 (PMEPA1) inhibits androgen and TGF-beta signaling via a negative feedback loop.	Androgens	68-76	prostate transmembrane protein, androgen induced 1	Homo sapiens	51-57
31842254-3	2019	The loss of PMEPA1 confers resistance to androgen signaling inhibitors and promotes bone metastasis.	Androgens	41-49	prostate transmembrane protein, androgen induced 1	Homo sapiens	12-18
31842254-10	2019	TGF-beta-responsive PMEPA1-a promoted PCa cell growth, and androgen-responsive PMEPA1-b inhibited cancer cell proliferation.	Androgens	59-67	prostate transmembrane protein, androgen induced 1	Homo sapiens	79-85
31842254-11	2019	PMEPA1 isoforms -a and -b were shown to be promising candidate biomarkers indicating PCa aggressiveness including earlier biochemical relapse and lower disease specific life expectancy via interrupting androgen/TGF-beta signaling.	Androgens	202-210	prostate transmembrane protein, androgen induced 1	Homo sapiens	0-6
31816863-3	2019	Progression from androgen-sensitive PCa to CRPC is promoted by inflammatory signaling through cyclooxygenase-2 (COX-2) expression and ErbB family receptors/AKT activation, compensating androgen receptor inactivity.	Androgens	17-25	prostaglandin-endoperoxide synthase 2	Homo sapiens	94-110
31866827-0	2019	Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal CA1 Pyramidal Neurons.	Androgens	88-96	carbonic anhydrase 1	Rattus norvegicus	122-125
31816863-7	2019	Epidermal growth factor receptor (EGFR), ErbB2, and ErbB3 degradation, and heterogeneous nuclear ribonucleoprotein K (hnRNP K) downregulation, further amplified the inhibition of androgen signaling.	Androgens	179-187	epidermal growth factor receptor	Homo sapiens	0-32
31816863-3	2019	Progression from androgen-sensitive PCa to CRPC is promoted by inflammatory signaling through cyclooxygenase-2 (COX-2) expression and ErbB family receptors/AKT activation, compensating androgen receptor inactivity.	Androgens	17-25	prostaglandin-endoperoxide synthase 2	Homo sapiens	112-117
31816863-7	2019	Epidermal growth factor receptor (EGFR), ErbB2, and ErbB3 degradation, and heterogeneous nuclear ribonucleoprotein K (hnRNP K) downregulation, further amplified the inhibition of androgen signaling.	Androgens	179-187	epidermal growth factor receptor	Homo sapiens	34-38
31816863-3	2019	Progression from androgen-sensitive PCa to CRPC is promoted by inflammatory signaling through cyclooxygenase-2 (COX-2) expression and ErbB family receptors/AKT activation, compensating androgen receptor inactivity.	Androgens	17-25	epidermal growth factor receptor	Homo sapiens	134-138
31816863-7	2019	Epidermal growth factor receptor (EGFR), ErbB2, and ErbB3 degradation, and heterogeneous nuclear ribonucleoprotein K (hnRNP K) downregulation, further amplified the inhibition of androgen signaling.	Androgens	179-187	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	75-116
31816863-3	2019	Progression from androgen-sensitive PCa to CRPC is promoted by inflammatory signaling through cyclooxygenase-2 (COX-2) expression and ErbB family receptors/AKT activation, compensating androgen receptor inactivity.	Androgens	17-25	AKT serine/threonine kinase 1	Homo sapiens	156-159
31816863-7	2019	Epidermal growth factor receptor (EGFR), ErbB2, and ErbB3 degradation, and heterogeneous nuclear ribonucleoprotein K (hnRNP K) downregulation, further amplified the inhibition of androgen signaling.	Androgens	179-187	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	118-125
31698174-4	2019	However, of particular importance are point mutations in the ligand binding domain of the protein that convert anti-androgens into potent AR agonists.	Androgens	116-125	androgen receptor	Homo sapiens	138-140
31810188-0	2019	Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Female Adolescents.	Androgens	51-60	spexin hormone	Homo sapiens	6-12
31810188-7	2019	In the OB/OW adolescents spexin levels correlated positively with testosterone (rs = 0.727, p = 0.011) and free androgen index (rs = 0.755, p = 0.007).	Androgens	112-120	spexin hormone	Homo sapiens	25-31
31871879-7	2019	The downstream targets of androgen receptors, such as PSA, TMPRSS2, and TMEPA1, were found decreased in the presence of kaempferol in qPCR data.	Androgens	26-34	aminopeptidase puromycin sensitive	Homo sapiens	54-57
31871879-7	2019	The downstream targets of androgen receptors, such as PSA, TMPRSS2, and TMEPA1, were found decreased in the presence of kaempferol in qPCR data.	Androgens	26-34	transmembrane serine protease 2	Homo sapiens	59-66
31669915-0	2019	Glucagon-like peptide-1 receptor expression and its functions are regulated by androgen.	Androgens	79-87	glucagon-like peptide 1 receptor	Mus musculus	0-32
31669915-10	2019	Taken together, the widely expressed GLP-1R was positively regulated by androgen under physiological condition and in diabetic models at the transcriptional level.	Androgens	72-80	glucagon-like peptide 1 receptor	Mus musculus	37-43
31791961-0	2019	Editor"s Note: PrLZ Protects Prostate Cancer Cells from Apoptosis Induced by Androgen Deprivation via the Activation of Stat3/Bcl-2 Pathway.	Androgens	77-85	tumor protein D52	Homo sapiens	15-19
31792211-0	2019	LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer.	Androgens	23-31	leucine rich repeats and immunoglobulin like domains 1	Homo sapiens	0-5
32016030-0	2019	Serial bipolar androgen therapy (sBAT) using cyclic supraphysiologic testosterone (STP) to treat metastatic castration-resistant prostate cancer (mCRPC).	Androgens	15-23	thyroid hormone receptor interactor 10	Homo sapiens	83-86
32042745-4	2019	We suggest that restored expression of FKBP51 gene, modulated by androgen receptor splicing variant 7 (AR-V7) which replaces full length androgen receptor (AR-FL) in androgen ablation status, promotes CRPC progression through activating NF-kappaB signaling.	Androgens	65-73	androgen receptor	Homo sapiens	103-105
32042745-4	2019	We suggest that restored expression of FKBP51 gene, modulated by androgen receptor splicing variant 7 (AR-V7) which replaces full length androgen receptor (AR-FL) in androgen ablation status, promotes CRPC progression through activating NF-kappaB signaling.	Androgens	65-73	nuclear factor kappa B subunit 1	Homo sapiens	237-246
32042745-4	2019	We suggest that restored expression of FKBP51 gene, modulated by androgen receptor splicing variant 7 (AR-V7) which replaces full length androgen receptor (AR-FL) in androgen ablation status, promotes CRPC progression through activating NF-kappaB signaling.	Androgens	137-145	androgen receptor	Homo sapiens	65-82
32042745-4	2019	We suggest that restored expression of FKBP51 gene, modulated by androgen receptor splicing variant 7 (AR-V7) which replaces full length androgen receptor (AR-FL) in androgen ablation status, promotes CRPC progression through activating NF-kappaB signaling.	Androgens	137-145	androgen receptor	Homo sapiens	103-105
31609094-2	2019	A proportion of SDC are characterized by HER2 amplification and/or overexpression of androgen receptor (AR), which could be targeted in a subset of patients, but the presence of AR splice variant-7 (AR-V7) in some SDC cases could result in resistance to anti-androgen therapy.	Androgens	85-93	androgen receptor	Homo sapiens	104-106
31735954-2	2019	SUMMARY ANSWER: Exposure of granulosa cells (GCs) to high levels of androgens, equivalent to that found in PCOS, prevented the fall in AMH and was associated with dysregulated AMH-SMAD signalling leading to stalled follicle progression in PCOS.	Androgens	68-77	anti-Mullerian hormone	Homo sapiens	135-138
31735954-9	2019	PARTICIPANTS/MATERIALS, SETTING, METHODS: AMH protein production by cells exposed to androgens was measured by ELISA.	Androgens	85-94	anti-Mullerian hormone	Homo sapiens	42-45
31735954-27	2019	The AMH decline may either be a direct effect of androgens or an indirect one via conversion to oestradiol and acting through the upregulation of ERalpha, which is known to stimulate the AMH promoter.	Androgens	49-58	anti-Mullerian hormone	Homo sapiens	4-7
31735954-2	2019	SUMMARY ANSWER: Exposure of granulosa cells (GCs) to high levels of androgens, equivalent to that found in PCOS, prevented the fall in AMH and was associated with dysregulated AMH-SMAD signalling leading to stalled follicle progression in PCOS.	Androgens	68-77	anti-Mullerian hormone	Homo sapiens	176-179
31735954-2	2019	SUMMARY ANSWER: Exposure of granulosa cells (GCs) to high levels of androgens, equivalent to that found in PCOS, prevented the fall in AMH and was associated with dysregulated AMH-SMAD signalling leading to stalled follicle progression in PCOS.	Androgens	68-77	SMAD family member 4	Homo sapiens	180-184
31788014-16	2019	Blocking androgen receptors can decreases the expression of CPTI in the skeletal muscle, which reduces fat metabolism.	Androgens	9-17	carnitine palmitoyltransferase 1b, muscle	Mus musculus	60-64
31713287-2	2019	Estradiol is synthesized from androgen precursor by cytochrome P450 aromatase (CYP19A1), and in cattle CYP19A1 messenger RNA has a short half-life but a long (3.5 kb) 3"-untranslated region (3"UTR), suggesting that posttranscriptional regulation may be important for control of enzyme activity.	Androgens	30-38	aromatase	Bos taurus	79-86
31713287-2	2019	Estradiol is synthesized from androgen precursor by cytochrome P450 aromatase (CYP19A1), and in cattle CYP19A1 messenger RNA has a short half-life but a long (3.5 kb) 3"-untranslated region (3"UTR), suggesting that posttranscriptional regulation may be important for control of enzyme activity.	Androgens	30-38	aromatase	Bos taurus	103-110
31761786-7	2019	Knockdown of MYSM1 promoted cell proliferation and suppressed senescence of CRPC cells under condition of androgen ablation.	Androgens	106-114	myb-like, SWIRM and MPN domains 1	Mus musculus	13-18
31761786-10	2019	MYSM1 was able to bind to androgen receptor instead of increasing its expression and knockdown of MYSM1 resulted in activation of Akt/c-Raf/GSK-3beta signaling.	Androgens	26-34	myb-like, SWIRM and MPN domains 1	Mus musculus	0-5
31781523-5	2019	Using a QPCR microarray and QRTPCR we found that PO was sufficient to increase expression of the androgen response gene Nkx3.1.	Androgens	97-105	NK3 homeobox 1	Mus musculus	120-126
31762940-2	2019	It has been described that PCA3 modulates prostate cancer (PCa) cell survival through modulating androgen receptor (AR) signaling, besides controlling the expression of several androgen responsive and cancer-related genes, including epithelial-mesenchymal transition (EMT) markers and those regulating gene expression and cell signaling.	Androgens	97-105	prostate cancer associated 3	Homo sapiens	27-31
31762940-2	2019	It has been described that PCA3 modulates prostate cancer (PCa) cell survival through modulating androgen receptor (AR) signaling, besides controlling the expression of several androgen responsive and cancer-related genes, including epithelial-mesenchymal transition (EMT) markers and those regulating gene expression and cell signaling.	Androgens	97-105	androgen receptor	Homo sapiens	116-118
31737354-2	2019	Aromatase is the key enzyme that catalyzes estrogen biosynthesis from androgen precursors and regulates the brain"s neurosteroidogenic activity.	Androgens	70-78	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
31578588-8	2019	In addition, the palmitoylation level of Ras-related protein Rab-7a (Rab7a) was enhanced by androgen treatment.	Androgens	92-100	RAB7A, member RAS oncogene family	Homo sapiens	61-67
31781523-13	2019	As Nkx3.1 is an androgen response gene, our data suggest a possible mechanism by which fibrosis is mediated in male mice and opens the possibility of a molecular pathway mediated by NKX3.1 that could explain sexual dimorphism in bladder fibrosis.	Androgens	16-24	NK3 homeobox 1	Mus musculus	3-9
31578588-8	2019	In addition, the palmitoylation level of Ras-related protein Rab-7a (Rab7a) was enhanced by androgen treatment.	Androgens	92-100	RAB7A, member RAS oncogene family	Homo sapiens	69-74
31725884-20	2019	Also, the relationships between intrafollicular AMH, gonadotropin and androgen levels in the same follicle support the hypothesis that FF AMH concentration may reflect granulosa cell proliferation during gonadotropin-stimulated follicle growth.	Androgens	70-78	anti-Mullerian hormone	Homo sapiens	138-141
31684907-5	2019	RESULTS: Here we demonstrated, in estrogen receptor alpha (ERalpha)-positive breast cancer cells, an androgen-dependent mechanism through which ligand-activated androgen receptor (AR) decreases estradiol-induced cyclin D1 protein, mRNA and gene promoter activity.	Androgens	101-109	estrogen receptor 1	Homo sapiens	59-66
31684907-5	2019	RESULTS: Here we demonstrated, in estrogen receptor alpha (ERalpha)-positive breast cancer cells, an androgen-dependent mechanism through which ligand-activated androgen receptor (AR) decreases estradiol-induced cyclin D1 protein, mRNA and gene promoter activity.	Androgens	101-109	androgen receptor	Homo sapiens	161-178
31684907-5	2019	RESULTS: Here we demonstrated, in estrogen receptor alpha (ERalpha)-positive breast cancer cells, an androgen-dependent mechanism through which ligand-activated androgen receptor (AR) decreases estradiol-induced cyclin D1 protein, mRNA and gene promoter activity.	Androgens	101-109	androgen receptor	Homo sapiens	180-182
31684907-5	2019	RESULTS: Here we demonstrated, in estrogen receptor alpha (ERalpha)-positive breast cancer cells, an androgen-dependent mechanism through which ligand-activated androgen receptor (AR) decreases estradiol-induced cyclin D1 protein, mRNA and gene promoter activity.	Androgens	101-109	cyclin D1	Homo sapiens	212-221
31684907-9	2019	In addition, ChIP analysis evidenced that androgen administration decreased E2-induced recruitment of AIB1 on the AP-1 site containing region of the cyclin D1 gene promoter.	Androgens	42-50	ANIB1	Homo sapiens	102-106
31684907-9	2019	In addition, ChIP analysis evidenced that androgen administration decreased E2-induced recruitment of AIB1 on the AP-1 site containing region of the cyclin D1 gene promoter.	Androgens	42-50	cyclin D1	Homo sapiens	149-158
31933595-11	2019	Conclusions: CYP17A1 is strongly expressed in half about of human prostate carcinomas, implying an intracellular androgen synthesis by cancer cells.	Androgens	113-121	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	13-20
31684907-5	2019	RESULTS: Here we demonstrated, in estrogen receptor alpha (ERalpha)-positive breast cancer cells, an androgen-dependent mechanism through which ligand-activated androgen receptor (AR) decreases estradiol-induced cyclin D1 protein, mRNA and gene promoter activity.	Androgens	101-109	estrogen receptor 1	Homo sapiens	34-57
31671654-3	2019	However, studies on the effects of leptin on the proliferation and apoptosis of the androgen-sensitive LNCaP line of prostate cancer cells brought conflicting results.	Androgens	84-92	leptin	Homo sapiens	35-41
31664946-4	2019	Prostate specific antigen (PSA) is the product of an androgen-responsive gene.	Androgens	53-61	kallikrein related peptidase 3	Homo sapiens	0-31
31734656-3	2019	Aromatase inhibitors can increase testosterone and androgen production without increasing the amount of estrogen in circulation.	Androgens	51-59	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
31671779-1	2019	Androgen receptor (AR) stimulators, such as androgen and Tip60, play a pivotal role in prostatic carcinogenesis as androgen receptor signaling is critical for the growth and transformation of the prostate gland.	Androgens	44-52	androgen receptor	Homo sapiens	0-17
31671779-1	2019	Androgen receptor (AR) stimulators, such as androgen and Tip60, play a pivotal role in prostatic carcinogenesis as androgen receptor signaling is critical for the growth and transformation of the prostate gland.	Androgens	44-52	androgen receptor	Homo sapiens	19-21
31671779-1	2019	Androgen receptor (AR) stimulators, such as androgen and Tip60, play a pivotal role in prostatic carcinogenesis as androgen receptor signaling is critical for the growth and transformation of the prostate gland.	Androgens	44-52	androgen receptor	Homo sapiens	115-132
31671779-2	2019	Moreover, androgen and Tip60 promotes HIF-1alpha activation, involved in metabolic reprogramming by increasing glycolysis, a hallmark in cancer initiation and development.	Androgens	10-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-48
31671779-3	2019	In this study we evaluated the effect of androgen and Tip60 stimulus in AR pathway activation and HIF-1alpha stabilization, in terms of proliferation and cell metabolism in androgen-sensitive LNCaP cells.	Androgens	173-181	lysine acetyltransferase 5	Homo sapiens	54-59
31671779-6	2019	These bioactive compounds prevented the increase in glycolysis, hexokinase and pyruvate kinase activity, and reduced HIF-1alpha stabilization induced by androgen and Tip60 in LNCaP cells.	Androgens	153-161	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
31638934-3	2019	We have recently shown that ERG regulates intra-tumoral androgen synthesis and thereby facilitates AR function in prostate cancer cells.	Androgens	56-64	ETS transcription factor ERG	Homo sapiens	28-31
31638934-15	2019	CONCLUSIONS: These data suggest that ERG transcription factor regulates androgen biosynthetic enzyme expression that enzalutamide treatment is more effective against VCaP bone tumors with an intact ERG expression, and that knocking down ERG in VCaP cells leads to a lesser response to enzalutamide therapy.	Androgens	72-80	ETS transcription factor ERG	Homo sapiens	37-40
31635359-8	2019	We report the radiosensitizing effect of anti-androgens, which showed synergism in combination with EBRT in AR-expressing tumor slices and cell lines.	Androgens	46-55	androgen receptor	Homo sapiens	108-110
31615010-5	2019	Androgen signaling induces the overexpression of prostate-specific antigen (PSA) and cell proliferation factor such as proliferating cell nuclear antigen (PCNA) and cyclin D1.	Androgens	0-8	kallikrein related peptidase 3	Homo sapiens	49-80
31615010-5	2019	Androgen signaling induces the overexpression of prostate-specific antigen (PSA) and cell proliferation factor such as proliferating cell nuclear antigen (PCNA) and cyclin D1.	Androgens	0-8	proliferating cell nuclear antigen	Homo sapiens	155-159
31615010-5	2019	Androgen signaling induces the overexpression of prostate-specific antigen (PSA) and cell proliferation factor such as proliferating cell nuclear antigen (PCNA) and cyclin D1.	Androgens	0-8	cyclin D1	Homo sapiens	165-174
31615010-7	2019	Polymerized anthocyanin (PA) downregulated the expression of androgen signaling-related proteins such as 5AR2, AR, and PSA in LNCaP cell lines.	Androgens	61-69	androgen receptor	Homo sapiens	106-108
31615010-7	2019	Polymerized anthocyanin (PA) downregulated the expression of androgen signaling-related proteins such as 5AR2, AR, and PSA in LNCaP cell lines.	Androgens	61-69	kallikrein related peptidase 3	Homo sapiens	119-122
31649965-3	2019	The HAT paralogs p300 and CREB-binding protein (CBP) have been implicated in human pathological conditions including several hematological malignancies and androgen receptor-positive prostate cancer.	Androgens	156-164	E1A binding protein p300	Homo sapiens	17-21
31649965-3	2019	The HAT paralogs p300 and CREB-binding protein (CBP) have been implicated in human pathological conditions including several hematological malignancies and androgen receptor-positive prostate cancer.	Androgens	156-164	CREB binding protein	Homo sapiens	26-46
31649965-3	2019	The HAT paralogs p300 and CREB-binding protein (CBP) have been implicated in human pathological conditions including several hematological malignancies and androgen receptor-positive prostate cancer.	Androgens	156-164	CREB binding protein	Homo sapiens	48-51
31572520-3	2019	Androgen-independent human prostate cancer cell lines PC3 and DU145 were used in the current study.	Androgens	0-8	proprotein convertase subtilisin/kexin type 1	Homo sapiens	54-57
31572520-6	2019	Androgen-independent human prostate cancer cell lines PC3 and DU145 were transfected with pim-1-targeted or control shRNA, and MTT results revealed that pim-1 knockdown significantly inhibited PC3 and DU145 cell viability in a time-dependent manner (P<0.01).	Androgens	0-8	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	90-95
31572520-6	2019	Androgen-independent human prostate cancer cell lines PC3 and DU145 were transfected with pim-1-targeted or control shRNA, and MTT results revealed that pim-1 knockdown significantly inhibited PC3 and DU145 cell viability in a time-dependent manner (P<0.01).	Androgens	0-8	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	153-158
31557897-7	2019	On the other hand, several tumor suppressor pathways act on or are activated by STAT3/5 signaling, including tyrosine phosphatases, the sumo ligase Protein Inhibitor of Activated STAT3 (PIAS3), the E3 ubiquitin ligase TATA Element Modulatory Factor/Androgen Receptor-Coactivator of 160 kDa (TMF/ARA160), the miRNAs miR-124 and miR-1181, the Protein of alternative reading frame 19 (p19ARF)/p53 pathway and the Suppressor of Cytokine Signaling 1 and 3 (SOCS1/3) proteins.	Androgens	249-257	signal transducer and activator of transcription 3	Homo sapiens	80-87
31681690-2	2019	A genetic variation at the level of aromatase enzyme gene (CYP19 gene) and/or androgen receptors with subsequent increased ovarian androgen was suggested in PCOS.	Androgens	131-139	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	59-64
31557897-7	2019	On the other hand, several tumor suppressor pathways act on or are activated by STAT3/5 signaling, including tyrosine phosphatases, the sumo ligase Protein Inhibitor of Activated STAT3 (PIAS3), the E3 ubiquitin ligase TATA Element Modulatory Factor/Androgen Receptor-Coactivator of 160 kDa (TMF/ARA160), the miRNAs miR-124 and miR-1181, the Protein of alternative reading frame 19 (p19ARF)/p53 pathway and the Suppressor of Cytokine Signaling 1 and 3 (SOCS1/3) proteins.	Androgens	249-257	signal transducer and activator of transcription 3	Homo sapiens	80-85
31620371-8	2019	Among the six ECM genes, SPP1 was identified as the key hub signature for PCa metastasis and drug resistance development; we found that both protein and mRNA expression levels of SPP1 were remarkably up-regulated in mCRPC compared with HSPC in organoid models and could regulate the androgen receptor signaling pathway.	Androgens	283-291	secreted phosphoprotein 1	Homo sapiens	179-183
31547021-8	2019	Androgens suppress Th1/Th2/Th17 and induce Treg.	Androgens	0-9	negative elongation factor complex member C/D	Homo sapiens	19-22
31547059-0	2019	CPT1A Supports Castration-Resistant Prostate Cancer in Androgen-Deprived Conditions.	Androgens	55-63	carnitine palmitoyltransferase 1A	Homo sapiens	0-5
31547059-3	2019	In this study, we focused on the role of the lipid catabolism enzyme CPT1A in supporting CRPC growth in an androgen-dependent manner.	Androgens	107-115	carnitine palmitoyltransferase 1A	Homo sapiens	69-74
31547059-4	2019	We found that androgen withdrawal promoted the growth of CPT1A over-expressing (OE) tumors while it decreased the growth of CPT1A under-expressing (KD) tumors, increasing their sensitivity to enzalutamide.	Androgens	14-22	carnitine palmitoyltransferase 1A	Homo sapiens	57-62
31547059-4	2019	We found that androgen withdrawal promoted the growth of CPT1A over-expressing (OE) tumors while it decreased the growth of CPT1A under-expressing (KD) tumors, increasing their sensitivity to enzalutamide.	Androgens	14-22	carnitine palmitoyltransferase 1A	Homo sapiens	124-129
31547059-6	2019	Conversely, CPT1A-KD cells showed less histone acetylation when grown in androgen-deprived conditions.	Androgens	73-81	carnitine palmitoyltransferase 1A	Homo sapiens	12-17
31551480-0	2019	Drivers of AR indifferent anti-androgen resistance in prostate cancer cells.	Androgens	31-39	androgen receptor	Homo sapiens	11-13
31551480-1	2019	Inhibition of the androgen receptor (AR) by second-generation anti-androgens is a standard treatment for metastatic castration resistant prostate cancer (mCRPC), but it inevitably leads to the development of resistance.	Androgens	67-76	androgen receptor	Homo sapiens	18-35
31551480-1	2019	Inhibition of the androgen receptor (AR) by second-generation anti-androgens is a standard treatment for metastatic castration resistant prostate cancer (mCRPC), but it inevitably leads to the development of resistance.	Androgens	67-76	androgen receptor	Homo sapiens	37-39
31551480-6	2019	RNA-seq analysis of the anti-androgen resistant cell lines identified hyper-activation of the E2F cell-cycle master regulator as driver of AR indifferent growth, which was caused by deregulation of cyclin D/E, E2F1, RB1, and increased Myc activity.	Androgens	29-37	androgen receptor	Homo sapiens	139-141
31551480-6	2019	RNA-seq analysis of the anti-androgen resistant cell lines identified hyper-activation of the E2F cell-cycle master regulator as driver of AR indifferent growth, which was caused by deregulation of cyclin D/E, E2F1, RB1, and increased Myc activity.	Androgens	29-37	E2F transcription factor 1	Homo sapiens	198-214
31551480-6	2019	RNA-seq analysis of the anti-androgen resistant cell lines identified hyper-activation of the E2F cell-cycle master regulator as driver of AR indifferent growth, which was caused by deregulation of cyclin D/E, E2F1, RB1, and increased Myc activity.	Androgens	29-37	RB transcriptional corepressor 1	Homo sapiens	216-219
31551480-6	2019	RNA-seq analysis of the anti-androgen resistant cell lines identified hyper-activation of the E2F cell-cycle master regulator as driver of AR indifferent growth, which was caused by deregulation of cyclin D/E, E2F1, RB1, and increased Myc activity.	Androgens	29-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	235-238
31723719-3	2019	The functional significance of this network was supported by our discovery that a truncated protein splice variant of the DENND1A gene, termed DENND1A.V2, is elevated in PCOS theca cells, and that forced expression of DENND1A.V2 in normal theca cells increased CYP11A1 and CYP17A1 expression and androgen synthesis, a hallmark of PCOS.	Androgens	296-304	DENN domain containing 1A	Homo sapiens	122-129
31723719-3	2019	The functional significance of this network was supported by our discovery that a truncated protein splice variant of the DENND1A gene, termed DENND1A.V2, is elevated in PCOS theca cells, and that forced expression of DENND1A.V2 in normal theca cells increased CYP11A1 and CYP17A1 expression and androgen synthesis, a hallmark of PCOS.	Androgens	296-304	DENN domain containing 1A	Homo sapiens	143-150
31723719-3	2019	The functional significance of this network was supported by our discovery that a truncated protein splice variant of the DENND1A gene, termed DENND1A.V2, is elevated in PCOS theca cells, and that forced expression of DENND1A.V2 in normal theca cells increased CYP11A1 and CYP17A1 expression and androgen synthesis, a hallmark of PCOS.	Androgens	296-304	DENN domain containing 1A	Homo sapiens	143-150
31723719-10	2019	This cytological evidence, and the previously reported increase in androgen biosynthesis with forced expression of DENND1A.V2 in normal theca cells, raises the possibility that DENND1A.V2 and RAB5B participate in increasing transcription of genes involved in androgen synthesis.	Androgens	67-75	DENN domain containing 1A	Homo sapiens	177-184
31723719-10	2019	This cytological evidence, and the previously reported increase in androgen biosynthesis with forced expression of DENND1A.V2 in normal theca cells, raises the possibility that DENND1A.V2 and RAB5B participate in increasing transcription of genes involved in androgen synthesis.	Androgens	67-75	RAB5B, member RAS oncogene family	Homo sapiens	192-197
31723719-10	2019	This cytological evidence, and the previously reported increase in androgen biosynthesis with forced expression of DENND1A.V2 in normal theca cells, raises the possibility that DENND1A.V2 and RAB5B participate in increasing transcription of genes involved in androgen synthesis.	Androgens	259-267	DENN domain containing 1A	Homo sapiens	115-122
31723719-10	2019	This cytological evidence, and the previously reported increase in androgen biosynthesis with forced expression of DENND1A.V2 in normal theca cells, raises the possibility that DENND1A.V2 and RAB5B participate in increasing transcription of genes involved in androgen synthesis.	Androgens	259-267	DENN domain containing 1A	Homo sapiens	177-184
31723719-10	2019	This cytological evidence, and the previously reported increase in androgen biosynthesis with forced expression of DENND1A.V2 in normal theca cells, raises the possibility that DENND1A.V2 and RAB5B participate in increasing transcription of genes involved in androgen synthesis.	Androgens	259-267	RAB5B, member RAS oncogene family	Homo sapiens	192-197
31956215-8	2019	The Combined Androgen Blockade (CAB) therapy was effective in reducing PSA value and shrinkage of the paraaortic lymph nodes.	Androgens	13-21	aminopeptidase puromycin sensitive	Homo sapiens	71-74
31552182-1	2019	Most prostate cancers are androgen-sensitive malignancies whose growths depend on the transcriptional activity of the androgen receptor (AR).	Androgens	26-34	androgen receptor	Homo sapiens	118-135
31552182-1	2019	Most prostate cancers are androgen-sensitive malignancies whose growths depend on the transcriptional activity of the androgen receptor (AR).	Androgens	26-34	androgen receptor	Homo sapiens	137-139
31555207-2	2019	GRTH is the only family member regulated by hormones, luteinizing hormone, through androgen action.	Androgens	83-91	DEAD-box helicase 25	Homo sapiens	0-4
31555207-6	2019	In Leydig cells, GRTH gene transcription is regulated by LH via autocrine actions of androgen/androgen receptor and has regulatory effects in steroidogenesis.	Androgens	85-93	DEAD-box helicase 25	Homo sapiens	17-21
31555207-6	2019	In Leydig cells, GRTH gene transcription is regulated by LH via autocrine actions of androgen/androgen receptor and has regulatory effects in steroidogenesis.	Androgens	94-102	DEAD-box helicase 25	Homo sapiens	17-21
31555207-8	2019	Transgenic mice carrying GRTH 5" flanking region-GFP permitted to discern regions in the gene which directs its expression upstream, in germ cells, and downstream in Leydig cells, and the androgen-regulated transcription at interstitial (autocrine), and germ cell (paracrine) compartments.	Androgens	188-196	DEAD box helicase 25	Mus musculus	25-29
31555207-9	2019	Further evidence for paracrine actions of androgen/androgen receptor is their transcriptional induction of Germ Cell Nuclear Factor as requisite up-regulator of GRTH gene transcription in round spermatids, linking androgen action to two relevant germ cell genes essential for the progress of spermatogenesis.	Androgens	42-50	DEAD-box helicase 25	Homo sapiens	161-165
31555207-9	2019	Further evidence for paracrine actions of androgen/androgen receptor is their transcriptional induction of Germ Cell Nuclear Factor as requisite up-regulator of GRTH gene transcription in round spermatids, linking androgen action to two relevant germ cell genes essential for the progress of spermatogenesis.	Androgens	51-59	DEAD-box helicase 25	Homo sapiens	161-165
31555207-9	2019	Further evidence for paracrine actions of androgen/androgen receptor is their transcriptional induction of Germ Cell Nuclear Factor as requisite up-regulator of GRTH gene transcription in round spermatids, linking androgen action to two relevant germ cell genes essential for the progress of spermatogenesis.	Androgens	51-59	DEAD-box helicase 25	Homo sapiens	161-165
31590136-10	2019	Mafb, belonging to AP-1 family and a key androgen-responsive mesenchymal gene, is identified and starts to be expressed around E14.5 when masculinization of the urethra is initiated.	Androgens	41-49	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	Mus musculus	0-4
31582976-0	2019	Retracted: Vesicle-Associated Membrane Protein-Associated Protein A Is Involved in Androgen Receptor Trafficking in Mouse Sertoli Cells.	Androgens	83-91	vesicle-associated membrane protein, associated protein A	Mus musculus	11-67
31656809-0	2019	Neoadjuvant androgen deprivation therapy through intense inhibition of the androgen target: "Midsummer Night"s Dream" or "Much Ado About Nothing"?	Androgens	12-20	potassium voltage-gated channel interacting protein 3	Homo sapiens	111-117
31656809-0	2019	Neoadjuvant androgen deprivation therapy through intense inhibition of the androgen target: "Midsummer Night"s Dream" or "Much Ado About Nothing"?	Androgens	75-83	potassium voltage-gated channel interacting protein 3	Homo sapiens	111-117
31807251-12	2019	Conclusion: Excess levels of testosterone could act differently from its physiological concentration to regulate hypothalamic androgen sensitive neurons to control GnRH cell.	Androgens	126-134	gonadotropin releasing hormone 1	Rattus norvegicus	164-168
31555580-2	2019	The prostate is a hormone-dependent gland in which androgen hormones testosterone and dihydrotestosterone bind to and activate the androgen receptor, initiating nuclear translocation of androgen receptor and a subsequent signaling cascade.	Androgens	51-59	androgen receptor	Homo sapiens	131-148
31555580-2	2019	The prostate is a hormone-dependent gland in which androgen hormones testosterone and dihydrotestosterone bind to and activate the androgen receptor, initiating nuclear translocation of androgen receptor and a subsequent signaling cascade.	Androgens	51-59	androgen receptor	Homo sapiens	186-203
31966711-2	2017	In this study, the expression of ERbeta was overexpressed in two androgen-independent prostate cancer cell lines, PC-3 and DU145 after transfection with Ad-ERbeta-EGFP virus particles.	Androgens	65-73	estrogen receptor 1	Homo sapiens	33-39
31966711-7	2017	In conclusion, these results suggest that estrogen may play an important role in androgen-independent prostate cancer cell proliferation through ERbeta-mediated suppression of TGF-beta1/IGF-1.	Androgens	81-89	estrogen receptor 1	Homo sapiens	145-151
31966711-7	2017	In conclusion, these results suggest that estrogen may play an important role in androgen-independent prostate cancer cell proliferation through ERbeta-mediated suppression of TGF-beta1/IGF-1.	Androgens	81-89	transforming growth factor beta 1	Homo sapiens	176-185
31966711-7	2017	In conclusion, these results suggest that estrogen may play an important role in androgen-independent prostate cancer cell proliferation through ERbeta-mediated suppression of TGF-beta1/IGF-1.	Androgens	81-89	insulin like growth factor 1	Homo sapiens	186-191
31994100-2	2017	TGF-beta production from dermal papillae is enhanced by androgens, and growth inhibition of hair-follicle cells is induced by TGF-beta, and the hair cycle progresses from the anagen phase to the catagen phase.	Androgens	56-65	transforming growth factor alpha	Homo sapiens	0-8