PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24511683-4	2013	After therapeutic infusions of the antioxidants mexidol or emoxypin, oxidative hemolysis in patients was restored to normal values and blood hepcidin content increased significantly.	6-methyl-2-ethyl-3-hydroxypyridine	59-67	hepcidin antimicrobial peptide	Homo sapiens	141-149
25033564-1	2014	The dependence of the antidepressant action of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin, and mexidol) on the insulin potentiating activity of these therapeutic agents has been studied in experiments on rats.	6-methyl-2-ethyl-3-hydroxypyridine	92-101	insulin	Homo sapiens	134-141
25033564-3	2014	It was established that single administration of emoxipine, reamberin, mexidol and alpha-lipoic acid in optimal doses, corresponding to the therapeutic range in humans, increased the sensitivity of animals to insulin according to the criterion of insulin coma development.	6-methyl-2-ethyl-3-hydroxypyridine	49-58	insulin	Homo sapiens	209-216
25033564-5	2014	Standardization of obtained data by average difference from the control and further correlation analysis demonstrated that the extent of antidepressant action of emoxipine, reamberin, mexidol and alpha-lipoic acid considerably depends on their insulin potentiating activity (r = 0.762, p = 0.004).	6-methyl-2-ethyl-3-hydroxypyridine	162-171	insulin	Homo sapiens	244-251
23887452-5	2013	Additionally, a two-week administration of emoxipine and mexidol led to a decreased percentage of lipofuscin-positive neurons in the neocortex and field CA1 of the hippocampus.	6-methyl-2-ethyl-3-hydroxypyridine	43-52	carbonic anhydrase 1	Rattus norvegicus	153-156
23667872-7	2013	Emoxipin and mexidol caused an increase in the counts of neurons and oligodendrocytes in CA1 field.	6-methyl-2-ethyl-3-hydroxypyridine	0-8	carbonic anhydrase 1	Rattus norvegicus	89-92
3111882-1	1987	It was shown that pretreatment of rats with antioxidants (AO) butylhydroxytoluene and 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride owing to its effect of animal protection against intoxication with diethylnitrosamine (DENA) increases the liver activity of enzymes of stage II metabolism of xenobiotics: glutathione-S-transferase (GST), UDP-glucuronyltransferase (UDP-GT).	6-methyl-2-ethyl-3-hydroxypyridine	86-134	hematopoietic prostaglandin D synthase	Rattus norvegicus	307-332
23323329-2	2012	It is established that the inclusion of emoxipin, reamberin and mexidol in complex treatment of IDUA recrudescence reduce depression, anxiety and SIR laboratory signs.	6-methyl-2-ethyl-3-hydroxypyridine	40-48	alpha-L-iduronidase	Homo sapiens	96-100
21240346-3	2011	3-Hydroxypyridine derivatives (emoxipin and mexidol) producing an antioxidant effect in vitro increase glucose tolerance, but exhibit relatively weak insulin-potentiating activity.	6-methyl-2-ethyl-3-hydroxypyridine	31-39	insulin	Homo sapiens	150-157
21809693-3	2011	Single administration of emoxipine, reamberin, and mexidol in optimal doses prevented lipofuscin deposition in CA1 field neurocytes in hippocampus and/or increased the amount of terminally differentiated cells ofneuroectodermal lineage (oligodendrocytes, pyramid and basket cells) in this zone ofpaleocortex.	6-methyl-2-ethyl-3-hydroxypyridine	25-34	carbonic anhydrase 1	Rattus norvegicus	111-114
10726316-3	1999	PV 1, 3, 4, 7 inhibited lipid peroxidation at the concentrations 100-fold, then those of PV 2 and emoxypine.	6-methyl-2-ethyl-3-hydroxypyridine	98-107	plasmalemma vesicle associated protein	Homo sapiens	0-4
9949468-7	1998	RESULTS: Emoxipine-treated patients had reduced content of primary lipid peroxidation products and schiff bases in AM, catalase level in them returned to normal, blood levels of alpha-tocopherol went up.	6-methyl-2-ethyl-3-hydroxypyridine	9-18	catalase	Homo sapiens	119-127
1805067-7	1991	The main mechanism of the antioxidative action of emoxipine in CHF was to enhance glutathione reductase and glutathione peroxidase and to lower the level on dienic conjugates in patients with Stage IIB CHF.	6-methyl-2-ethyl-3-hydroxypyridine	50-59	glutathione-disulfide reductase	Homo sapiens	82-103
2558741-1	1989	The influence of emoxypin (derivate of 3-hydroxypyridine) upon the late receptor potential (LRP) and activity of the cyclic 3",5"-nucleotide phosphodiesterase (PDE) have been investigated.	6-methyl-2-ethyl-3-hydroxypyridine	17-25	LDL receptor related protein 1	Homo sapiens	67-90
2558741-1	1989	The influence of emoxypin (derivate of 3-hydroxypyridine) upon the late receptor potential (LRP) and activity of the cyclic 3",5"-nucleotide phosphodiesterase (PDE) have been investigated.	6-methyl-2-ethyl-3-hydroxypyridine	17-25	LDL receptor related protein 1	Homo sapiens	92-95
2558741-4	1989	Thus, emoxypin produces an effect on the LRP like classical inhibitors of PDE.	6-methyl-2-ethyl-3-hydroxypyridine	6-14	LDL receptor related protein 1	Homo sapiens	41-44
21240346-1	2011	We studied the correlation between the effect of alpha-lipoic acid, emoxipin, reamberin, and mexidol on LPO in vitro and the action of these drugs on insulin sensitivity and tolerance to glucose load in vivo.	6-methyl-2-ethyl-3-hydroxypyridine	68-76	lactoperoxidase	Homo sapiens	104-107
15656396-3	2004	The positive clinical effect of emoxipine and reamberine was shown to be associated with the stimulation of AOD and with the limitation of LPO.	6-methyl-2-ethyl-3-hydroxypyridine	32-41	lactoperoxidase	Homo sapiens	139-142
34222086-0	2021	The effect of methylethylpiridinol addition to the therapy on the level of pigment epithelium-derived factor and oxidative status in patients with diabetic nephropathy: randomized controlled open-label clinical study.	6-methyl-2-ethyl-3-hydroxypyridine	14-34	serpin family F member 1	Homo sapiens	75-108
34222086-2	2021	For the first time, authors investigated the effect of methylethylpiridinol addition to the therapy on oxidative status and pigment epithelium-derived factor concentrations, and examined the relationship between these indicators and clinical markers of pathology development.	6-methyl-2-ethyl-3-hydroxypyridine	55-75	serpin family F member 1	Homo sapiens	124-157
34222086-4	2021	Authors assessed the effect of methylethylpiridinol addition to the therapy vs basic treatment on antioxidant and NADPH-generating enzymes activity, glutathione"s concentration and free radical-induced oxidation"s intensity using a spectrophotometric method and iron-induced biochemiluminescence.	6-methyl-2-ethyl-3-hydroxypyridine	31-51	2,4-dienoyl-CoA reductase 1	Homo sapiens	114-119
34222086-9	2021	Conclusions: The methylethylpiridinol addition to the therapy had a more potent stimulating effect on the patients" oxidative status in comparison with standard treatment, and reliably decreased pigment epithelium-derived factor level in patients" serum.	6-methyl-2-ethyl-3-hydroxypyridine	17-37	serpin family F member 1	Homo sapiens	195-228
3111882-1	1987	It was shown that pretreatment of rats with antioxidants (AO) butylhydroxytoluene and 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride owing to its effect of animal protection against intoxication with diethylnitrosamine (DENA) increases the liver activity of enzymes of stage II metabolism of xenobiotics: glutathione-S-transferase (GST), UDP-glucuronyltransferase (UDP-GT).	6-methyl-2-ethyl-3-hydroxypyridine	86-134	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	367-373
3111882-1	1987	It was shown that pretreatment of rats with antioxidants (AO) butylhydroxytoluene and 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride owing to its effect of animal protection against intoxication with diethylnitrosamine (DENA) increases the liver activity of enzymes of stage II metabolism of xenobiotics: glutathione-S-transferase (GST), UDP-glucuronyltransferase (UDP-GT).	6-methyl-2-ethyl-3-hydroxypyridine	86-134	hematopoietic prostaglandin D synthase	Rattus norvegicus	334-337
3111882-1	1987	It was shown that pretreatment of rats with antioxidants (AO) butylhydroxytoluene and 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride owing to its effect of animal protection against intoxication with diethylnitrosamine (DENA) increases the liver activity of enzymes of stage II metabolism of xenobiotics: glutathione-S-transferase (GST), UDP-glucuronyltransferase (UDP-GT).	6-methyl-2-ethyl-3-hydroxypyridine	86-134	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	340-365
6640098-3	1983	Supplementation of the incubation medium with the antioxidant, 2-ethyl-6-methyl-3-hydroxypyridine (HP-6), inhibits LPO, on the one hand, and stabilizes cytochrome P-450, on the other one.	6-methyl-2-ethyl-3-hydroxypyridine	63-97	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	152-168