PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31133754-9 2019 We further show that F. oxysporum uses APS to regulate spore germination in a cell-density-dependent manner, whereby the alpha-Ste2 interaction leads to repression of conidial germination while the a-Ste3 interaction relieves repression. aps 39-42 alpha-factor pheromone receptor STE2 Saccharomyces cerevisiae S288C 127-131 31133754-9 2019 We further show that F. oxysporum uses APS to regulate spore germination in a cell-density-dependent manner, whereby the alpha-Ste2 interaction leads to repression of conidial germination while the a-Ste3 interaction relieves repression. aps 39-42 Ste3p Saccharomyces cerevisiae S288C 200-204 31254308-1 2019 BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) is a homologue of angiotensin-converting enzyme (ACE) and produces angiotensin peptides (APs), such as angiotensin 1-9 and 1-7 that are vasodilatory and natriuretic, and act to counterbalance angiotensin II. aps 140-143 angiotensin converting enzyme 2 Canis lupus familiaris 12-43 31112706-3 2019 Urinary excretion of BaP and cotinine (a metabolite of nicotine) increased in a time-dependent manner increased after supplementation with APS (BaP, 2.23-fold; cotinine, 2.64-fold), propolis (BaP, 1.30-fold; cotinine, 2.08-fold), and the mixture (BaP, 2.33-fold; cotinine, 2.28-fold) compared with smoker control. aps 139-142 BAR/IMD domain containing adaptor protein 2 Homo sapiens 144-150 31112706-3 2019 Urinary excretion of BaP and cotinine (a metabolite of nicotine) increased in a time-dependent manner increased after supplementation with APS (BaP, 2.23-fold; cotinine, 2.64-fold), propolis (BaP, 1.30-fold; cotinine, 2.08-fold), and the mixture (BaP, 2.33-fold; cotinine, 2.28-fold) compared with smoker control. aps 139-142 BRCA1 associated protein 1 Homo sapiens 192-198 31112706-3 2019 Urinary excretion of BaP and cotinine (a metabolite of nicotine) increased in a time-dependent manner increased after supplementation with APS (BaP, 2.23-fold; cotinine, 2.64-fold), propolis (BaP, 1.30-fold; cotinine, 2.08-fold), and the mixture (BaP, 2.33-fold; cotinine, 2.28-fold) compared with smoker control. aps 139-142 BAR/IMD domain containing adaptor protein 2 Homo sapiens 247-253 31418381-5 2019 APS decreased the expression of Caspase-3 and inhibited the reduction of mitochondrial membrane potential induced by LY294002, moreover, APS could increase the activation of PI3K /AKT pathway in Plt. aps 0-3 caspase 3 Homo sapiens 32-41 31418381-5 2019 APS decreased the expression of Caspase-3 and inhibited the reduction of mitochondrial membrane potential induced by LY294002, moreover, APS could increase the activation of PI3K /AKT pathway in Plt. aps 0-3 AKT serine/threonine kinase 1 Homo sapiens 180-183 31418381-5 2019 APS decreased the expression of Caspase-3 and inhibited the reduction of mitochondrial membrane potential induced by LY294002, moreover, APS could increase the activation of PI3K /AKT pathway in Plt. aps 137-140 caspase 3 Homo sapiens 32-41 31418381-5 2019 APS decreased the expression of Caspase-3 and inhibited the reduction of mitochondrial membrane potential induced by LY294002, moreover, APS could increase the activation of PI3K /AKT pathway in Plt. aps 137-140 AKT serine/threonine kinase 1 Homo sapiens 180-183 31418381-6 2019 CONCLUSION: APS has an anti-apoptotic effect on the cryopreserved platelets through activating the PI3K /AKT pathway, decreasing the expression of apoptosis protease Caspase-3 and inhibiting the reduction of MMP. aps 12-15 AKT serine/threonine kinase 1 Homo sapiens 105-108 31418381-6 2019 CONCLUSION: APS has an anti-apoptotic effect on the cryopreserved platelets through activating the PI3K /AKT pathway, decreasing the expression of apoptosis protease Caspase-3 and inhibiting the reduction of MMP. aps 12-15 caspase 3 Homo sapiens 166-175 31254308-1 2019 BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) is a homologue of angiotensin-converting enzyme (ACE) and produces angiotensin peptides (APs), such as angiotensin 1-9 and 1-7 that are vasodilatory and natriuretic, and act to counterbalance angiotensin II. aps 140-143 angiotensin converting enzyme 2 Canis lupus familiaris 45-49 31254308-1 2019 BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) is a homologue of angiotensin-converting enzyme (ACE) and produces angiotensin peptides (APs), such as angiotensin 1-9 and 1-7 that are vasodilatory and natriuretic, and act to counterbalance angiotensin II. aps 140-143 angiotensin I converting enzyme Canis lupus familiaris 69-98 31254308-1 2019 BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) is a homologue of angiotensin-converting enzyme (ACE) and produces angiotensin peptides (APs), such as angiotensin 1-9 and 1-7 that are vasodilatory and natriuretic, and act to counterbalance angiotensin II. aps 140-143 angiotensin I converting enzyme Canis lupus familiaris 45-48 31184131-3 2019 Here, we develop a sequential protein-responsive aPS (PcC4-MSN-O1) that is based on zinc(II) phthalocyanine derivative (PcC4)-entrapped mesoporous silica nanoparticles (MSNs) and a wrapping DNA (O1) as a biogate. aps 49-52 moesin Homo sapiens 59-62 30590152-6 2019 The secretion and gene expression of NO/iNOS, IL-6 and TNF-alpha in APS-induced macrophage cell were significantly enhanced. aps 68-71 nitric oxide synthase 2, inducible Mus musculus 40-44 31117931-10 2019 RESULTS: APS treatment significantly decreased the expression of miR-195, while increased the expression of Bcl-2 with optimized dosages which were induced by HG treatment, even after replacing the HG with NG. aps 9-12 microRNA 195 Homo sapiens 65-72 31117931-10 2019 RESULTS: APS treatment significantly decreased the expression of miR-195, while increased the expression of Bcl-2 with optimized dosages which were induced by HG treatment, even after replacing the HG with NG. aps 9-12 BCL2 apoptosis regulator Homo sapiens 108-113 31117931-12 2019 APS alleviated the oxidative stress, mitochondrial damage and cell apoptosis induced by HG and HG + NG treatments in RPE cells via regulating miR-195. aps 0-3 microRNA 195 Homo sapiens 142-149 31117931-13 2019 Furthermore, we found overexpression of miR-195 abolished the alleviated effects of APS on the HG-treated RPE cells. aps 84-87 microRNA 195 Homo sapiens 40-47 31117931-14 2019 CONCLUSIONS: APS suppressed high glucose-induced metabolic memory in retinal pigment epithelial cells through inhibiting mitochondrial dysfunction-induced apoptosis by regulating miR-195. aps 13-16 microRNA 195 Homo sapiens 179-186 30813073-7 2019 Although APS did not significantly inhibit the growth of MCF-7 cells growth, encouragingly, APS-activated RAW264.7 macrophages present anti-cancer activity as evidenced by (a) cell proliferation inhibition (with an inhibitory rate of 41%), (b) G1-phase cell cycle arrest, as well as (c) the regulation of apoptosis-related genes (Bax/Bcl-2, 13.26-fold increase than untreated cells). aps 92-95 BCL2 associated X, apoptosis regulator Homo sapiens 330-333 30813073-7 2019 Although APS did not significantly inhibit the growth of MCF-7 cells growth, encouragingly, APS-activated RAW264.7 macrophages present anti-cancer activity as evidenced by (a) cell proliferation inhibition (with an inhibitory rate of 41%), (b) G1-phase cell cycle arrest, as well as (c) the regulation of apoptosis-related genes (Bax/Bcl-2, 13.26-fold increase than untreated cells). aps 92-95 BCL2 apoptosis regulator Homo sapiens 334-339 30590152-6 2019 The secretion and gene expression of NO/iNOS, IL-6 and TNF-alpha in APS-induced macrophage cell were significantly enhanced. aps 68-71 interleukin 6 Mus musculus 46-50 30590152-6 2019 The secretion and gene expression of NO/iNOS, IL-6 and TNF-alpha in APS-induced macrophage cell were significantly enhanced. aps 68-71 tumor necrosis factor Mus musculus 55-64 30590152-7 2019 However, APS-induced TNF-alpha production was decreased by blocking the MAPK or NF-kappaB signaling pathways, especially for the blockade of p38. aps 9-12 tumor necrosis factor Mus musculus 21-30 30590152-9 2019 Therefore, we demonstrated that APS could improve the immune functions of RAW 264.7 macrophages cells by promoting the cell viability and increasing secretion and gene expressions of NO/iNOS, IL-6 and TNF-alpha through the MAPK and NF-kappaB signaling pathways. aps 32-35 nitric oxide synthase 2, inducible Mus musculus 186-190 30590152-9 2019 Therefore, we demonstrated that APS could improve the immune functions of RAW 264.7 macrophages cells by promoting the cell viability and increasing secretion and gene expressions of NO/iNOS, IL-6 and TNF-alpha through the MAPK and NF-kappaB signaling pathways. aps 32-35 interleukin 6 Mus musculus 192-196 30590152-9 2019 Therefore, we demonstrated that APS could improve the immune functions of RAW 264.7 macrophages cells by promoting the cell viability and increasing secretion and gene expressions of NO/iNOS, IL-6 and TNF-alpha through the MAPK and NF-kappaB signaling pathways. aps 32-35 tumor necrosis factor Mus musculus 201-210 30925971-1 2019 The aim of this study was to determine the effect of Astragalus polysaccharide (APS) on the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) in mice with Lewis transplantable lung cancer. aps 80-83 vascular endothelial growth factor A Mus musculus 106-140 30925971-1 2019 The aim of this study was to determine the effect of Astragalus polysaccharide (APS) on the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) in mice with Lewis transplantable lung cancer. aps 80-83 vascular endothelial growth factor A Mus musculus 142-146 30925971-1 2019 The aim of this study was to determine the effect of Astragalus polysaccharide (APS) on the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) in mice with Lewis transplantable lung cancer. aps 80-83 epidermal growth factor receptor Mus musculus 152-184 30925971-1 2019 The aim of this study was to determine the effect of Astragalus polysaccharide (APS) on the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) in mice with Lewis transplantable lung cancer. aps 80-83 epidermal growth factor receptor Mus musculus 186-190 30925971-6 2019 The research results showed that APS can effectively inhibit the growth and metastasis of Lewis lung cancer in mice, improve immune organ function, inhibit the protein expression of VEGF and EGFR in tumor tissues, and have a concentration-effect relationships. aps 33-36 vascular endothelial growth factor A Mus musculus 182-186 30925971-6 2019 The research results showed that APS can effectively inhibit the growth and metastasis of Lewis lung cancer in mice, improve immune organ function, inhibit the protein expression of VEGF and EGFR in tumor tissues, and have a concentration-effect relationships. aps 33-36 epidermal growth factor receptor Mus musculus 191-195 27754762-5 2017 The APs bound specifically to the CCKBR, and we showed not only that they did not stimulate proliferation of PDAC cell lines but rather inhibited their proliferation. aps 4-7 cholecystokinin B receptor Homo sapiens 34-39 30339971-8 2019 Most APs exhibited CD10-positive (100%; 72/72) and desmin-positive (97%; 70/72) stroma. aps 5-8 membrane metalloendopeptidase Homo sapiens 19-23 30048421-4 2018 RESULTS It was shown that APS could attenuate 1-methyl-4-pheyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction (P<0.01), increase the proportion of TH-positive cells (P<0.01), reverse MPTP-induced mitochondrial structural damage, and reduce MPTP-induced high levels of reactive oxygen species (ROS) and increase MPTP-induced decrease in mitochondrial membrane potential. aps 26-29 tyrosine hydroxylase Mus musculus 160-162 30048421-5 2018 In addition, APS also decreased the bax/bcl2 ratio, and cytochrome-c and caspase-3 protein content (P<0.01) in substantia nigra in our mouse PD model. aps 13-16 BCL2-associated X protein Mus musculus 36-39 30048421-5 2018 In addition, APS also decreased the bax/bcl2 ratio, and cytochrome-c and caspase-3 protein content (P<0.01) in substantia nigra in our mouse PD model. aps 13-16 B cell leukemia/lymphoma 2 Mus musculus 40-44 30048421-5 2018 In addition, APS also decreased the bax/bcl2 ratio, and cytochrome-c and caspase-3 protein content (P<0.01) in substantia nigra in our mouse PD model. aps 13-16 caspase 3 Mus musculus 73-82 29573714-6 2018 Potency balance analysis revealed that only 3% and 22% of the AhR- and ER-mediated potencies could be explained by identified known chemicals, such as PAHs and APs, respectively. aps 160-163 aryl hydrocarbon receptor Homo sapiens 62-65 28894122-3 2017 Under oxidizing conditions RRM2 forms disulfide-bonded dimers that experience unfolding and then assemble into aggregate particles (APs). aps 132-135 ribonucleotide reductase regulatory subunit M2 Homo sapiens 27-31 28212986-4 2017 Compared with no preservative control, each of the APs decreased the conformational stability of mAb-4 as measured by differential scanning calorimetry and extrinsic fluorescence spectroscopy. aps 51-54 immunoglobulin kappa variable 4-62 Mus musculus 97-102 28212986-6 2017 The extent of conformational destabilization and protein aggregation of mAb-4 induced by APs followed their calculated octanol-water partition coefficients. aps 89-92 immunoglobulin kappa variable 4-62 Mus musculus 72-77 28212986-8 2017 Based on these results, the destabilizing effect of APs on mAb-4 correlates with the increased hydrophobicity of the APs and their ability to enhance the local backbone flexibility of an aggregation hot spot within the CH2 domain of the mAb. aps 52-55 immunoglobulin kappa variable 4-62 Mus musculus 59-64 28212986-8 2017 Based on these results, the destabilizing effect of APs on mAb-4 correlates with the increased hydrophobicity of the APs and their ability to enhance the local backbone flexibility of an aggregation hot spot within the CH2 domain of the mAb. aps 117-120 immunoglobulin kappa variable 4-62 Mus musculus 59-64 30692224-7 2019 We demonstrate that the proliferation rate of APs or BPs is not changed, but the switch of APs to BPs is dramatically accelerated in Pen-2 cKO cortices. aps 91-94 presenilin enhancer gamma secretase subunit Mus musculus 133-138 30692224-9 2019 We report that expression of Notch1 intracellular domain in Pen-2 cKO cortices restores the population of APs and BPs. aps 106-109 notch 1 Mus musculus 29-35 30692224-9 2019 We report that expression of Notch1 intracellular domain in Pen-2 cKO cortices restores the population of APs and BPs. aps 106-109 presenilin enhancer gamma secretase subunit Mus musculus 60-65 30610831-11 2019 Furthermore, APS (20 mg/kg) administration obviously upregulated the phosphorylation levels CREB, NMDA, and CaMK II. aps 13-16 cAMP responsive element binding protein 1 Rattus norvegicus 92-96 29684344-8 2018 APs were effective in interfering with the FFA-induced activation of the PERK and IRE1 pathways as well as ROS generation, thereby protecting pancreatic beta-cells from lipotoxicity. aps 0-3 eukaryotic translation initiation factor 2 alpha kinase 3 Mus musculus 73-77 29684344-8 2018 APs were effective in interfering with the FFA-induced activation of the PERK and IRE1 pathways as well as ROS generation, thereby protecting pancreatic beta-cells from lipotoxicity. aps 0-3 endoplasmic reticulum (ER) to nucleus signalling 2 Mus musculus 82-86 29607874-7 2018 Besides, western blot results revealed APS induced NRG1 expressing and the phosphorylation level of ErbB2/4. aps 39-42 neuregulin 1 Homo sapiens 51-55 29607874-7 2018 Besides, western blot results revealed APS induced NRG1 expressing and the phosphorylation level of ErbB2/4. aps 39-42 erb-b2 receptor tyrosine kinase 2 Homo sapiens 100-105 29607874-8 2018 In addition, the elevated NRG1 promoted AKT and PI3k phosphorylation which indicated APS may exert its function by NRG1/ErbB and the downstream AKT/PI3K signaling. aps 85-88 neuregulin 1 Homo sapiens 26-30 29607874-8 2018 In addition, the elevated NRG1 promoted AKT and PI3k phosphorylation which indicated APS may exert its function by NRG1/ErbB and the downstream AKT/PI3K signaling. aps 85-88 AKT serine/threonine kinase 1 Homo sapiens 40-43 29607874-8 2018 In addition, the elevated NRG1 promoted AKT and PI3k phosphorylation which indicated APS may exert its function by NRG1/ErbB and the downstream AKT/PI3K signaling. aps 85-88 neuregulin 1 Homo sapiens 115-119 29607874-8 2018 In addition, the elevated NRG1 promoted AKT and PI3k phosphorylation which indicated APS may exert its function by NRG1/ErbB and the downstream AKT/PI3K signaling. aps 85-88 epidermal growth factor receptor Homo sapiens 120-124 29607874-8 2018 In addition, the elevated NRG1 promoted AKT and PI3k phosphorylation which indicated APS may exert its function by NRG1/ErbB and the downstream AKT/PI3K signaling. aps 85-88 AKT serine/threonine kinase 1 Homo sapiens 144-147 29607874-10 2018 The effect of APS on proliferation, apoptosis, antioxidation and NRG1/ErbB pathway was partly abolished after the cells were co-treated with APS and canertinib. aps 14-17 neuregulin 1 Homo sapiens 65-69 29607874-10 2018 The effect of APS on proliferation, apoptosis, antioxidation and NRG1/ErbB pathway was partly abolished after the cells were co-treated with APS and canertinib. aps 14-17 epidermal growth factor receptor Homo sapiens 70-74 29607874-10 2018 The effect of APS on proliferation, apoptosis, antioxidation and NRG1/ErbB pathway was partly abolished after the cells were co-treated with APS and canertinib. aps 141-144 neuregulin 1 Homo sapiens 65-69 29607874-10 2018 The effect of APS on proliferation, apoptosis, antioxidation and NRG1/ErbB pathway was partly abolished after the cells were co-treated with APS and canertinib. aps 141-144 epidermal growth factor receptor Homo sapiens 70-74 29607874-11 2018 Taken together, these results suggested APS may display its protective function in DCM cells by activating NGR1/ErbB signaling pathway. aps 40-43 epidermal growth factor receptor Homo sapiens 112-116 29127365-8 2017 Using HPI4, a small molecule that inhibits ciliogenesis, and siRNA against Kif-3A, we provide evidence that the primary cilium is necessary both for the differentiation of APs into myofibroblasts and the maintenance of the phenotype. aps 172-175 kinesin family member 3A Homo sapiens 75-81 27318677-4 2017 In live imaging experiments carried out in rat hippocampal astrocytes, Gq-coupled P2Y1 receptor blockade with the selective antagonist MRS2179 (1 muM) or inhibition of its effector phospholipase C using U73122 (3 muM) produced APs retraction, while stimulation of the same receptor with the selective agonist 2MeSADP (100 muM) increased their number. aps 227-230 purinergic receptor P2Y1 Rattus norvegicus 82-86 26305254-4 2015 The treatment with APs or atorvastatin induced a remarkable reduction in the atherosclerotic lesions and hepatic steatosis and decreased the levels of low-density lipoprotein, triglyceride, CCL-2 and VCAM-1 levels in the plasma. aps 19-22 chemokine (C-C motif) ligand 2 Mus musculus 190-195 27214098-4 2016 APS was isolated separately after activating rat platelets with thrombin 0.5 U/mL for 2 hours. aps 0-3 coagulation factor II Rattus norvegicus 64-72 27214098-8 2016 RESULT: Cytokines such as IL-1beta, IL-10, and TGFbeta were 3.7+-0.9-fold, 3.4+-1.2-fold, and 1.2+-0.1-fold higher in APS, respectively, compared with naive platelet supernatant. aps 118-121 interleukin 1 beta Rattus norvegicus 26-34 27214098-9 2016 By APS priming, (mob) PBMCs showed M2 polarization and upregulation of angiogenic molecules (i.e., TEK, IL-10, CXCL1, and CX3CR1). aps 3-6 sphingomyelin synthase 1 Rattus norvegicus 17-20 27214098-13 2016 CONCLUSION: Our data reveal that APS priming can enhance the wound-healing potential of (mob) PBMCs. aps 33-36 sphingomyelin synthase 1 Rattus norvegicus 89-92 25894228-6 2015 Here, we investigated if APS attenuates IL-1beta- or TNF-alpha-mediated IL-6 and IL-8 expression in SZ95 sebocytes, whereas TNF-alpha was used as control. aps 25-28 interleukin 1 beta Homo sapiens 40-49 25894228-6 2015 Here, we investigated if APS attenuates IL-1beta- or TNF-alpha-mediated IL-6 and IL-8 expression in SZ95 sebocytes, whereas TNF-alpha was used as control. aps 25-28 tumor necrosis factor Homo sapiens 53-62 25894228-6 2015 Here, we investigated if APS attenuates IL-1beta- or TNF-alpha-mediated IL-6 and IL-8 expression in SZ95 sebocytes, whereas TNF-alpha was used as control. aps 25-28 interleukin 6 Homo sapiens 72-76 25894228-6 2015 Here, we investigated if APS attenuates IL-1beta- or TNF-alpha-mediated IL-6 and IL-8 expression in SZ95 sebocytes, whereas TNF-alpha was used as control. aps 25-28 C-X-C motif chemokine ligand 8 Homo sapiens 81-85 25894228-11 2015 Concomitant treatment of SZ95 sebocytes with APS attenuated the effect of IL-1beta and TNF-alpha on IL-6 and IL-8 gene expression as well as on IL-1beta-mediated NF-kappaB signaling. aps 45-48 interleukin 1 beta Homo sapiens 74-82 25894228-11 2015 Concomitant treatment of SZ95 sebocytes with APS attenuated the effect of IL-1beta and TNF-alpha on IL-6 and IL-8 gene expression as well as on IL-1beta-mediated NF-kappaB signaling. aps 45-48 tumor necrosis factor Homo sapiens 87-96 25894228-11 2015 Concomitant treatment of SZ95 sebocytes with APS attenuated the effect of IL-1beta and TNF-alpha on IL-6 and IL-8 gene expression as well as on IL-1beta-mediated NF-kappaB signaling. aps 45-48 interleukin 6 Homo sapiens 100-104 25894228-11 2015 Concomitant treatment of SZ95 sebocytes with APS attenuated the effect of IL-1beta and TNF-alpha on IL-6 and IL-8 gene expression as well as on IL-1beta-mediated NF-kappaB signaling. aps 45-48 C-X-C motif chemokine ligand 8 Homo sapiens 109-113 25894228-11 2015 Concomitant treatment of SZ95 sebocytes with APS attenuated the effect of IL-1beta and TNF-alpha on IL-6 and IL-8 gene expression as well as on IL-1beta-mediated NF-kappaB signaling. aps 45-48 interleukin 1 beta Homo sapiens 144-152 26305254-4 2015 The treatment with APs or atorvastatin induced a remarkable reduction in the atherosclerotic lesions and hepatic steatosis and decreased the levels of low-density lipoprotein, triglyceride, CCL-2 and VCAM-1 levels in the plasma. aps 19-22 vascular cell adhesion molecule 1 Mus musculus 200-206 26305254-5 2015 Conversely, the APs significantly increased the plasma levels of high-density lipoprotein (HDL) cholesterol and markedly up-regulated the glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) levels in liver tissues. aps 16-19 catalase Mus musculus 168-176 26305254-5 2015 Conversely, the APs significantly increased the plasma levels of high-density lipoprotein (HDL) cholesterol and markedly up-regulated the glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) levels in liver tissues. aps 16-19 catalase Mus musculus 178-181 26305254-6 2015 Moreover, the APs treatment modulated lipid metabolism by up-regulating the transcription of associated hepatic genes including PPARalpha, while down-regulating the transcription of SCAP and its downstream genes associated with lipid synthesis in the liver. aps 14-17 peroxisome proliferator activated receptor alpha Mus musculus 128-137 26305254-6 2015 Moreover, the APs treatment modulated lipid metabolism by up-regulating the transcription of associated hepatic genes including PPARalpha, while down-regulating the transcription of SCAP and its downstream genes associated with lipid synthesis in the liver. aps 14-17 SREBF chaperone Mus musculus 182-186 26305254-9 2015 Mechanistically, the APs treatment suppressed the ROS/MAPK/NF-kappaB signaling pathway, and consequently, reduced CCL-2, ICAM-1 and VCAM-1 expression. aps 21-24 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 59-68 26305254-9 2015 Mechanistically, the APs treatment suppressed the ROS/MAPK/NF-kappaB signaling pathway, and consequently, reduced CCL-2, ICAM-1 and VCAM-1 expression. aps 21-24 chemokine (C-C motif) ligand 2 Mus musculus 114-119 26305254-9 2015 Mechanistically, the APs treatment suppressed the ROS/MAPK/NF-kappaB signaling pathway, and consequently, reduced CCL-2, ICAM-1 and VCAM-1 expression. aps 21-24 intercellular adhesion molecule 1 Mus musculus 121-127 26305254-9 2015 Mechanistically, the APs treatment suppressed the ROS/MAPK/NF-kappaB signaling pathway, and consequently, reduced CCL-2, ICAM-1 and VCAM-1 expression. aps 21-24 vascular cell adhesion molecule 1 Mus musculus 132-138 24981198-7 2014 APS contained high concentrations of anti-inflammatory proteins including 39,000 +- 20,000 pg/ml IL-1ra, 21,000 +- 5,000 pg/ml sIL-1RII, 2,100 +- 570 pg/ml sTNF-RI, and 4,200 +- 1,500 pg/ml sTNF-RII. aps 0-3 interleukin 1 receptor antagonist Homo sapiens 97-103 25730471-6 2015 Furthermore, we find that in multiple models of obesity, the activation of APs is dependent on the phosphoinositide 3-kinase (PI3K)-AKT2 pathway; however, the development of WAT does not require AKT2. aps 75-78 thymoma viral proto-oncogene 2 Mus musculus 132-136 25016235-6 2014 Compared to naive platelet supernatants, APS had a higher level of various cytokines, such as IL8, IL17, PDGF and VEGF. aps 41-44 C-X-C motif chemokine ligand 8 Homo sapiens 94-97 25016235-6 2014 Compared to naive platelet supernatants, APS had a higher level of various cytokines, such as IL8, IL17, PDGF and VEGF. aps 41-44 interleukin 17A Homo sapiens 99-103 25016235-6 2014 Compared to naive platelet supernatants, APS had a higher level of various cytokines, such as IL8, IL17, PDGF and VEGF. aps 41-44 vascular endothelial growth factor A Homo sapiens 114-118 25016235-7 2014 APS-priming for 6h induced (mob)PBSCs to express key angiogenic factors, surface markers (i.e. CD34, CD31, and CXCR4) and integrins (integrins alpha5, beta1 and beta2). aps 0-3 CD34 molecule Homo sapiens 95-99 25016235-7 2014 APS-priming for 6h induced (mob)PBSCs to express key angiogenic factors, surface markers (i.e. CD34, CD31, and CXCR4) and integrins (integrins alpha5, beta1 and beta2). aps 0-3 platelet and endothelial cell adhesion molecule 1 Homo sapiens 101-105 25016235-7 2014 APS-priming for 6h induced (mob)PBSCs to express key angiogenic factors, surface markers (i.e. CD34, CD31, and CXCR4) and integrins (integrins alpha5, beta1 and beta2). aps 0-3 C-X-C motif chemokine receptor 4 Homo sapiens 111-116 25016235-7 2014 APS-priming for 6h induced (mob)PBSCs to express key angiogenic factors, surface markers (i.e. CD34, CD31, and CXCR4) and integrins (integrins alpha5, beta1 and beta2). aps 0-3 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 161-166 24974985-6 2014 Similar to Cyt c, APs induced IFNA2 aggregation, demonstrated by the loss of soluble monomer and increase in solution turbidity. aps 18-21 interferon alpha 2 Homo sapiens 30-35 23434495-11 2013 These findings shed a light on main involvement of CYP3A4 in human hepatic elimination of APs, indicating potential drug interactions. aps 90-93 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 51-57 23862022-6 2013 We observed a dramatic downregulation of ninein in APs of the Pax6 mutant. aps 51-54 ninein Rattus norvegicus 41-47 23862022-6 2013 We observed a dramatic downregulation of ninein in APs of the Pax6 mutant. aps 51-54 paired box 6 Rattus norvegicus 62-66 23862022-10 2013 We also found that ninein knockdown enlarged the surface size area of apical endfeet of the APs. aps 92-95 ninein Rattus norvegicus 19-25 25958587-5 2014 Protein immobilization results also confirmed that a fibronectin (FN) proteins/large scale DNA scaffolds/aminopropylytriethoxysilane (APS)/SiO2/Si substrate with high sensitivity formed in a well-defined manner. aps 134-137 fibronectin 1 Homo sapiens 53-64 24383864-3 2014 To determine the level of antibodies against meningococcal A polysaccharide (APS) that correlates with protection against MenA disease in the African meningitis belt, it may be important to consider antibody avidity along with quantity. aps 77-80 ENAH actin regulator Homo sapiens 122-126 23359515-12 2014 RESULTS: Forty patients with CF were included in the analysis, CHIT1 duplication heterozygocity was found in 3/6 (50%) of the patients in the ABPM group, 3/12 (25%) in the APS group, and 7/22 (31.8%) in the control group (P > 0.05). aps 172-175 chitinase 1 Homo sapiens 63-68 24754180-5 2014 Compared to the human leukemia NOD/SCID mouse model group with the treatments of APS, Ara-c and APS + Ara-c, We found that severe liver damage and pathological changes of the liver were able to alleviate: First, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted K562 leukemia cells; Second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL) were significantly reduced, while the albumin (Alb) was notably increased; Third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly increased, and the contents of GSH and malonaldehyde (MDA) were decreased significantly in the liver; Fourth, the inflammation of the liver was relieved as the level of IL-1beta and IL-6, the inflammatory cytokines, were decreased significantly in the liver. aps 96-99 glutamic--pyruvic transaminase Homo sapiens 421-445 24754180-5 2014 Compared to the human leukemia NOD/SCID mouse model group with the treatments of APS, Ara-c and APS + Ara-c, We found that severe liver damage and pathological changes of the liver were able to alleviate: First, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted K562 leukemia cells; Second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL) were significantly reduced, while the albumin (Alb) was notably increased; Third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly increased, and the contents of GSH and malonaldehyde (MDA) were decreased significantly in the liver; Fourth, the inflammation of the liver was relieved as the level of IL-1beta and IL-6, the inflammatory cytokines, were decreased significantly in the liver. aps 96-99 solute carrier family 17 member 5 Homo sapiens 453-479 24754180-5 2014 Compared to the human leukemia NOD/SCID mouse model group with the treatments of APS, Ara-c and APS + Ara-c, We found that severe liver damage and pathological changes of the liver were able to alleviate: First, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted K562 leukemia cells; Second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL) were significantly reduced, while the albumin (Alb) was notably increased; Third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly increased, and the contents of GSH and malonaldehyde (MDA) were decreased significantly in the liver; Fourth, the inflammation of the liver was relieved as the level of IL-1beta and IL-6, the inflammatory cytokines, were decreased significantly in the liver. aps 96-99 solute carrier family 17 member 5 Homo sapiens 481-484 24754180-5 2014 Compared to the human leukemia NOD/SCID mouse model group with the treatments of APS, Ara-c and APS + Ara-c, We found that severe liver damage and pathological changes of the liver were able to alleviate: First, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted K562 leukemia cells; Second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL) were significantly reduced, while the albumin (Alb) was notably increased; Third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly increased, and the contents of GSH and malonaldehyde (MDA) were decreased significantly in the liver; Fourth, the inflammation of the liver was relieved as the level of IL-1beta and IL-6, the inflammatory cytokines, were decreased significantly in the liver. aps 96-99 albumin Homo sapiens 560-563 24754180-5 2014 Compared to the human leukemia NOD/SCID mouse model group with the treatments of APS, Ara-c and APS + Ara-c, We found that severe liver damage and pathological changes of the liver were able to alleviate: First, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted K562 leukemia cells; Second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL) were significantly reduced, while the albumin (Alb) was notably increased; Third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly increased, and the contents of GSH and malonaldehyde (MDA) were decreased significantly in the liver; Fourth, the inflammation of the liver was relieved as the level of IL-1beta and IL-6, the inflammatory cytokines, were decreased significantly in the liver. aps 96-99 interleukin 1 beta Homo sapiens 930-938 24754180-5 2014 Compared to the human leukemia NOD/SCID mouse model group with the treatments of APS, Ara-c and APS + Ara-c, We found that severe liver damage and pathological changes of the liver were able to alleviate: First, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted K562 leukemia cells; Second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBiL) were significantly reduced, while the albumin (Alb) was notably increased; Third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly increased, and the contents of GSH and malonaldehyde (MDA) were decreased significantly in the liver; Fourth, the inflammation of the liver was relieved as the level of IL-1beta and IL-6, the inflammatory cytokines, were decreased significantly in the liver. aps 96-99 interleukin 6 Homo sapiens 943-947 23704888-10 2013 In addition to findings of short alternating hydrophobic/hydrophilic segments within the PLIN protein family, we propose and discuss a model for the interaction of LD-coating APs with IF proteins. aps 175-178 perilipin 1 Homo sapiens 89-93 23416995-7 2013 The enzyme was found to also act as an alkane omega-hydroxylase that oxidized n-alkanes with various chain lengths (C9 to C12 and C15 to C19), as well as alkyl side chains (C3 to C9) in alkylphenols (APs). aps 200-203 placenta associated 8 Homo sapiens 130-133 22500403-10 2012 The strong positive c-kit immunoreactivity was present in the cytoplasmic of the MSCs in the DMEM/F12 medium experimental groups and the APS intervened medium groups. aps 137-140 KIT proto-oncogene receptor tyrosine kinase Mus musculus 20-25 23027008-5 2013 Another method utilizes aminopropyl silatrane (APS) to yield an APS-mica surface. aps 47-50 MHC class I polypeptide-related sequence A Homo sapiens 68-72 22298325-2 2012 The non-polar characteristics of the APS precursor are compatible with the CdS NC surface (oleylamine), which allows the direct dispersion of the CdS NCs without the need of any surfactant exchange. aps 37-40 CDP-diacylglycerol synthase 1 Homo sapiens 75-78 22298325-2 2012 The non-polar characteristics of the APS precursor are compatible with the CdS NC surface (oleylamine), which allows the direct dispersion of the CdS NCs without the need of any surfactant exchange. aps 37-40 CDP-diacylglycerol synthase 1 Homo sapiens 146-149 22298325-3 2012 Chemical crosslinking of the NC-APS dispersion via hydrosilylation between Si-H and the vinyl group in APS immobilizes the CdS NCs in the polysiloxane network. aps 32-35 CDP-diacylglycerol synthase 1 Homo sapiens 123-126 22298325-3 2012 Chemical crosslinking of the NC-APS dispersion via hydrosilylation between Si-H and the vinyl group in APS immobilizes the CdS NCs in the polysiloxane network. aps 103-106 CDP-diacylglycerol synthase 1 Homo sapiens 123-126 21463663-3 2011 Thirty minutes after APS, induced by a formalin injection into the left hind paw, PVN, BSTov, CeA and npEW all showed a peak in cFos mRNA expression that was followed by a robust increase in cFos protein-immunoreactivity, indicating a rapid increase in (immediate early) gene expression in all four brain nuclei. aps 21-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 128-132 21687998-6 2011 RESULTS: Both the rhIL-1ra and the APS reduced the effect of IL-1beta on human macrophages in vitro. aps 35-38 interleukin 1 beta Homo sapiens 61-69 21687998-8 2011 Further analysis of the supernatants confirmed the presence of high concentrations of IL-1ra and soluble TNF receptor I (sTNF-RI) with the APS treatment. aps 139-142 interleukin 1 receptor antagonist Homo sapiens 86-92 21687998-9 2011 CONCLUSION: The ability of the APS to reduce the effect of IL-1beta and limit the expression of other inflammatory cytokines in vitro validates its potential use as an autologous treatment for osteoarthritis. aps 31-34 interleukin 1 beta Homo sapiens 59-67 21463663-3 2011 Thirty minutes after APS, induced by a formalin injection into the left hind paw, PVN, BSTov, CeA and npEW all showed a peak in cFos mRNA expression that was followed by a robust increase in cFos protein-immunoreactivity, indicating a rapid increase in (immediate early) gene expression in all four brain nuclei. aps 21-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 191-195 19923196-2 2010 The key step in the pathway is the reduction of activated sulphate, adenosine 5"-phosphosulphate (APS), to sulphite catalysed by APS reductase (APR). aps 98-101 APS reductase 1 Arabidopsis thaliana 129-142 21043033-4 2011 The results demonstrated that pretreatment of PC12 cells with APS, prior to H(2)O(2) exposure, significantly increased the survival of cells and the activities of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD), and reduced the levels of LDH and MDA. aps 62-65 catalase Rattus norvegicus 196-204 21043033-4 2011 The results demonstrated that pretreatment of PC12 cells with APS, prior to H(2)O(2) exposure, significantly increased the survival of cells and the activities of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD), and reduced the levels of LDH and MDA. aps 62-65 catalase Rattus norvegicus 206-209 20206379-5 2010 Cell viability assays and FACS analysis of GFP expression against PC3 (PSMA deficient) and LNCaP (PSMA overexpressed) cells demonstrated that the synthesized APs inhibited the growth of PSMA-abundant prostate cancer cells with strong cell selectivity. aps 158-161 chromobox 8 Homo sapiens 66-69 20206379-5 2010 Cell viability assays and FACS analysis of GFP expression against PC3 (PSMA deficient) and LNCaP (PSMA overexpressed) cells demonstrated that the synthesized APs inhibited the growth of PSMA-abundant prostate cancer cells with strong cell selectivity. aps 158-161 folate hydrolase 1 Homo sapiens 71-75 20206379-5 2010 Cell viability assays and FACS analysis of GFP expression against PC3 (PSMA deficient) and LNCaP (PSMA overexpressed) cells demonstrated that the synthesized APs inhibited the growth of PSMA-abundant prostate cancer cells with strong cell selectivity. aps 158-161 folate hydrolase 1 Homo sapiens 98-102 20206379-5 2010 Cell viability assays and FACS analysis of GFP expression against PC3 (PSMA deficient) and LNCaP (PSMA overexpressed) cells demonstrated that the synthesized APs inhibited the growth of PSMA-abundant prostate cancer cells with strong cell selectivity. aps 158-161 folate hydrolase 1 Homo sapiens 98-102 20353016-6 2009 The expression of STAT5 has significant difference between APS group and the control group at 4 time points. aps 59-62 signal transducer and activator of transcription 5A Homo sapiens 18-23 20353016-7 2009 JAK2, STAT5 expressed in cytoplasm and nuclear of APS group significantly increased as compared to those of control group, and they expressed the strongest at 5 min. aps 50-53 Janus kinase 2 Homo sapiens 0-4 20353016-7 2009 JAK2, STAT5 expressed in cytoplasm and nuclear of APS group significantly increased as compared to those of control group, and they expressed the strongest at 5 min. aps 50-53 signal transducer and activator of transcription 5A Homo sapiens 6-11 20353016-8 2009 CONCLUSION: JAK2, STAT5 signal transduction molecule plays an important role in the effect of APS cooperated with Epo on promoting hematopoiesis. aps 94-97 Janus kinase 2 Homo sapiens 12-16 20353016-8 2009 CONCLUSION: JAK2, STAT5 signal transduction molecule plays an important role in the effect of APS cooperated with Epo on promoting hematopoiesis. aps 94-97 signal transducer and activator of transcription 5A Homo sapiens 18-23 20353016-8 2009 CONCLUSION: JAK2, STAT5 signal transduction molecule plays an important role in the effect of APS cooperated with Epo on promoting hematopoiesis. aps 94-97 erythropoietin Homo sapiens 114-117 19923196-2 2010 The key step in the pathway is the reduction of activated sulphate, adenosine 5"-phosphosulphate (APS), to sulphite catalysed by APS reductase (APR). aps 98-101 APS reductase 1 Arabidopsis thaliana 144-147 19361366-11 2009 All concentrations of the APs and SAD could decrease the level of IL-5 as compared with the untreated group, especially of the AP II-L and AP I-L (P<0.05, P<0.01). aps 26-29 interleukin 5 Homo sapiens 66-70 18353239-6 2008 The expression of the activated caspase-3 in the group of APS, PDGF and TPO were (12.27 +/- 5.18)%, (12.39 +/- 6.26)% and (13.75 +/- 8.25)%, the APS and PDGF group decreased significantly compared to the control group (18.92 +/- 6.09)%. aps 58-61 caspase 3 Homo sapiens 32-41 19364068-9 2008 Decreased MCP-1, IL-6, and IL-8 expression indicated that APS-purified islets were possibly exposed to less proinflammatory stress. aps 58-61 C-C motif chemokine ligand 2 Homo sapiens 10-15 19364068-9 2008 Decreased MCP-1, IL-6, and IL-8 expression indicated that APS-purified islets were possibly exposed to less proinflammatory stress. aps 58-61 interleukin 6 Homo sapiens 17-21 19364068-9 2008 Decreased MCP-1, IL-6, and IL-8 expression indicated that APS-purified islets were possibly exposed to less proinflammatory stress. aps 58-61 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 18028983-8 2008 Furthermore, test APs showed similar effect on the function of hERalpha and rERalpha. aps 18-21 estrogen receptor 1 Homo sapiens 63-84 18353239-7 2008 The ratio of total cell deaths in the APS, PDGF and TPO group were (23.64 +/- 6.69)%, (28.00 +/- 10.05)% and (27.99 +/- 8.99)%, the ratio in APS group decreased significantly compared to the control group (39.48 +/- 11.86)% by JC-1 method. aps 141-144 thrombopoietin Homo sapiens 52-55 17988090-6 2007 APS enhanced nitric oxide (NO) production and induced iNOS mRNA and protein expressions in RAW 264.7 murine macrophage cells. aps 0-3 nitric oxide synthase 2, inducible Mus musculus 54-58 17042973-6 2006 Further comparisons showed that there were also no significant correlations observed in group LTNPs, but Nef-specific CD8 T cells correlated negatively with viral load (r = -0.397, P = 0.020) and positively with CD4 count (r = 0.364, P = 0.034) in group APs. aps 254-257 Nef Human immunodeficiency virus 1 105-108 17276460-11 2007 We report the structure of the APS-kinase domain of human PAPSS1 in complex with two APS molecules, demonstrating the ability of the ATP/ADP-binding site to bind APS. aps 31-34 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 58-64 17105811-3 2007 We demonstrate for the first time that acquisition of APS by rested memory T cells is correlated with increased levels of apoptosis in vivo and up-regulation of caspase-3, bcl-x, bak, and bax in our in vitro studies. aps 54-57 caspase 3 Homo sapiens 161-170 17105811-3 2007 We demonstrate for the first time that acquisition of APS by rested memory T cells is correlated with increased levels of apoptosis in vivo and up-regulation of caspase-3, bcl-x, bak, and bax in our in vitro studies. aps 54-57 BCL2 like 1 Homo sapiens 172-177 17105811-3 2007 We demonstrate for the first time that acquisition of APS by rested memory T cells is correlated with increased levels of apoptosis in vivo and up-regulation of caspase-3, bcl-x, bak, and bax in our in vitro studies. aps 54-57 BCL2 associated X, apoptosis regulator Homo sapiens 188-191 17042973-6 2006 Further comparisons showed that there were also no significant correlations observed in group LTNPs, but Nef-specific CD8 T cells correlated negatively with viral load (r = -0.397, P = 0.020) and positively with CD4 count (r = 0.364, P = 0.034) in group APs. aps 254-257 CD8a molecule Homo sapiens 118-121 16169144-3 2005 DHT induced AR-mediated transcriptional activity in a concentration-dependent manner with median effective concentration (EC50) value of (3.90+/-1.43)x10(-10)M. Flutamide exhibited potent antiandrogenic activity with median inhibitory concentration (IC50) value of (1.02+/-0.35)x10(-7)M. Bisphenol A (BPA) and alkylphenols (APs) belong to the industrial chemicals that have received considerable attention due to high production and widespread usage. aps 324-327 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 12-14 16408179-2 2006 In this report we demonstrate that aps element also affects integration, transcription, and translation of a soybean protease inhibitor, Bowman-Birk inhibitor (BBI), in transgenic tomato plants and quantifies its effects in different expression vectors. aps 35-38 Bowman-Birk type proteinase inhibitor Glycine max 137-158 16408179-2 2006 In this report we demonstrate that aps element also affects integration, transcription, and translation of a soybean protease inhibitor, Bowman-Birk inhibitor (BBI), in transgenic tomato plants and quantifies its effects in different expression vectors. aps 35-38 Bowman-Birk type proteinase inhibitor Glycine max 160-163 16408179-6 2006 In tomato fruits and leaves, aps caused a 3-fold increase in bbi mRNA levels when compared to the lines without aps. aps 29-32 Bowman-Birk type proteinase inhibitor Glycine max 61-64 10563468-10 1999 CONCLUSIONS: Anti-beta2 GPI from APS appear to have a variable degree of C1q affinity. aps 33-36 apolipoprotein H Homo sapiens 18-27 12951527-2 2003 At pH 4.7, acid phosphatase (pI, 5.4), alpha-glucosidase (pI, 5.7), and beta-glucosidase (pI, 7.3) were inhibited by APS to various extents. aps 117-120 sucrase-isomaltase Homo sapiens 39-56 12574238-3 2003 Recently, we showed that APs (RU 486, ZK 137 316 and ZK 230 211) also elevate endometrial androgen receptor (AR) in macaques and women and we hypothesized that over expression of AR may play a role in the antiproliferative actions of APs. aps 25-28 androgen receptor Homo sapiens 90-107 12574238-3 2003 Recently, we showed that APs (RU 486, ZK 137 316 and ZK 230 211) also elevate endometrial androgen receptor (AR) in macaques and women and we hypothesized that over expression of AR may play a role in the antiproliferative actions of APs. aps 25-28 androgen receptor Homo sapiens 109-111 12574238-3 2003 Recently, we showed that APs (RU 486, ZK 137 316 and ZK 230 211) also elevate endometrial androgen receptor (AR) in macaques and women and we hypothesized that over expression of AR may play a role in the antiproliferative actions of APs. aps 25-28 androgen receptor Homo sapiens 179-181 12574238-3 2003 Recently, we showed that APs (RU 486, ZK 137 316 and ZK 230 211) also elevate endometrial androgen receptor (AR) in macaques and women and we hypothesized that over expression of AR may play a role in the antiproliferative actions of APs. aps 234-237 androgen receptor Homo sapiens 179-181 12574238-9 2003 These results indicate that many of the antiendometrial effects of APs in primates may involve the AR. aps 67-70 androgen receptor Homo sapiens 99-101 12585175-4 2002 After being induced by APS, the differentiation of K562 cells to erythrocyte series and granulo-monocyte series increased, positive rate of benzidine, glycogen and peroxidase stain elevated, and cell surface differential antigen CD15 expression promoted significantly (P < 0.05), while C-MYC expression of K562 cells induced by APS induction lowered significantly (P < 0.05). aps 23-26 fucosyltransferase 4 Homo sapiens 229-233 12585175-4 2002 After being induced by APS, the differentiation of K562 cells to erythrocyte series and granulo-monocyte series increased, positive rate of benzidine, glycogen and peroxidase stain elevated, and cell surface differential antigen CD15 expression promoted significantly (P < 0.05), while C-MYC expression of K562 cells induced by APS induction lowered significantly (P < 0.05). aps 23-26 MYC proto-oncogene, bHLH transcription factor Homo sapiens 289-294 11397870-2 2001 Here, we report that APs up-regulate endometrial androgen receptor (AR) in both women and macaques, an effect that might play a role in the antiproliferative effects of APs on the primate endometrium. aps 21-24 androgen receptor Homo sapiens 49-66 11397870-2 2001 Here, we report that APs up-regulate endometrial androgen receptor (AR) in both women and macaques, an effect that might play a role in the antiproliferative effects of APs on the primate endometrium. aps 21-24 androgen receptor Homo sapiens 68-70 11397870-2 2001 Here, we report that APs up-regulate endometrial androgen receptor (AR) in both women and macaques, an effect that might play a role in the antiproliferative effects of APs on the primate endometrium. aps 169-172 androgen receptor Homo sapiens 49-66 11397870-2 2001 Here, we report that APs up-regulate endometrial androgen receptor (AR) in both women and macaques, an effect that might play a role in the antiproliferative effects of APs on the primate endometrium. aps 169-172 androgen receptor Homo sapiens 68-70 11397870-15 2001 Because androgens can antagonize E(2) action, enhanced endometrial AR expression induced by APs could play a role in the antiproliferative, "antiestrogenic" effects of APs in primates. aps 92-95 androgen receptor Homo sapiens 67-69 11397870-15 2001 Because androgens can antagonize E(2) action, enhanced endometrial AR expression induced by APs could play a role in the antiproliferative, "antiestrogenic" effects of APs in primates. aps 168-171 androgen receptor Homo sapiens 67-69 15934078-12 2005 CONCLUSION: These findings widen our knowledge of the functional spectrum of APs and demonstrate that HBD-3 is a multifunctional AP with the ability to link host defense mechanisms and inflammation with tissue-remodeling processes in articular cartilage. aps 77-80 defensin beta 103B Homo sapiens 102-107 11179674-3 2001 Amino acid comparison suggested that predicted proteins were homologous to known mu1, mu3 and mu4 subunits of mammalian APs as they shared 69, 51, and 26% identity with mouse mu1A, human mu3A and human mu4, respectively. aps 120-123 glutathione S-transferase mu 1 Homo sapiens 81-84 11179674-3 2001 Amino acid comparison suggested that predicted proteins were homologous to known mu1, mu3 and mu4 subunits of mammalian APs as they shared 69, 51, and 26% identity with mouse mu1A, human mu3A and human mu4, respectively. aps 120-123 adaptor related protein complex 4 subunit mu 1 Homo sapiens 94-97 11179674-3 2001 Amino acid comparison suggested that predicted proteins were homologous to known mu1, mu3 and mu4 subunits of mammalian APs as they shared 69, 51, and 26% identity with mouse mu1A, human mu3A and human mu4, respectively. aps 120-123 adaptor-related protein complex AP-1, mu subunit 1 Mus musculus 175-179 11179674-3 2001 Amino acid comparison suggested that predicted proteins were homologous to known mu1, mu3 and mu4 subunits of mammalian APs as they shared 69, 51, and 26% identity with mouse mu1A, human mu3A and human mu4, respectively. aps 120-123 adaptor related protein complex 4 subunit mu 1 Homo sapiens 202-205 10563468-10 1999 CONCLUSIONS: Anti-beta2 GPI from APS appear to have a variable degree of C1q affinity. aps 33-36 complement C1q A chain Homo sapiens 73-76 33817185-1 2019 Aim: This study investigates the effect of astragalus polysaccharides (APS) in protecting against thapsigargin-induced endoplasmic reticulum (ER) stress in HT29 cells by suppressing the PERK-eIF2a signaling pathway. aps 71-74 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 186-190 12840868-6 1999 Our results suggested that APS of given dosage could prevent antigen-induced the number of eosinophils infiltrating into the airway of sensitized mice and inhibit the proliferation and activation of lymphocyte and IL-2 production. aps 27-30 interleukin 2 Mus musculus 214-218 10417330-0 1999 APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase. aps 0-3 insulin receptor Homo sapiens 73-89 10417330-4 1999 Here we show that APS interacts with the insulin receptor kinase activation loop through its SH2 domain and insulin stimulates the tyrosine-phosphorylation of APS. aps 18-21 insulin receptor Homo sapiens 41-57 10417330-4 1999 Here we show that APS interacts with the insulin receptor kinase activation loop through its SH2 domain and insulin stimulates the tyrosine-phosphorylation of APS. aps 159-162 insulin receptor Homo sapiens 41-57 8599879-5 1996 The sera of the mice were examined for the presence of different antiphospholipid Abs, and the beta 2 GPI dependency of aPS, using an enzyme-linked immunosorbent assay (ELISA). aps 120-123 apolipoprotein H Mus musculus 95-105 8599879-9 1996 Both IgG and IgM aPS were beta 2 GPI dependent and did not bind PS in the absence of the glycoprotein. aps 17-20 apolipoprotein H Mus musculus 26-36 33806007-4 2021 We characterized the activation of mouse TRPA1 by non-electrophilic alkylphenols (APs) of different carbon chain lengths in the para position of the aromatic ring. aps 82-85 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 41-46 33806007-8 2021 Thus, the potency of APs for TRPA1 activation is an increasing function of their ability to induce lipid order and membrane rigidity. aps 21-24 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 29-34 33817185-1 2019 Aim: This study investigates the effect of astragalus polysaccharides (APS) in protecting against thapsigargin-induced endoplasmic reticulum (ER) stress in HT29 cells by suppressing the PERK-eIF2a signaling pathway. aps 71-74 eukaryotic translation initiation factor 2 subunit alpha Homo sapiens 191-196 33817185-8 2019 Conclusion: The results indicate that APS reduces the expression of GRP78 and CHOP in HT29 cells, at least in part, by preventing the activation of the PERK-eIF2a signaling pathway. aps 38-41 heat shock protein family A (Hsp70) member 5 Homo sapiens 68-73 33817185-8 2019 Conclusion: The results indicate that APS reduces the expression of GRP78 and CHOP in HT29 cells, at least in part, by preventing the activation of the PERK-eIF2a signaling pathway. aps 38-41 DNA damage inducible transcript 3 Homo sapiens 78-82 33817185-8 2019 Conclusion: The results indicate that APS reduces the expression of GRP78 and CHOP in HT29 cells, at least in part, by preventing the activation of the PERK-eIF2a signaling pathway. aps 38-41 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 152-156 33817185-8 2019 Conclusion: The results indicate that APS reduces the expression of GRP78 and CHOP in HT29 cells, at least in part, by preventing the activation of the PERK-eIF2a signaling pathway. aps 38-41 eukaryotic translation initiation factor 2 subunit alpha Homo sapiens 157-162 34289209-6 2021 Consistent with the changes in MDSCs, the serum level of IL-6, IL-1beta was the lowest in the APS group. aps 94-97 interleukin 6 Mus musculus 57-61 34962345-8 2022 APS might enrich autophagy by activating AMP-activated protein kinase (AMPK) and inhibiting mammalian target of rapamycin (mTOR). aps 0-3 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 41-69 34962345-8 2022 APS might enrich autophagy by activating AMP-activated protein kinase (AMPK) and inhibiting mammalian target of rapamycin (mTOR). aps 0-3 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 71-75 34962345-8 2022 APS might enrich autophagy by activating AMP-activated protein kinase (AMPK) and inhibiting mammalian target of rapamycin (mTOR). aps 0-3 mechanistic target of rapamycin kinase Homo sapiens 92-121 34962345-8 2022 APS might enrich autophagy by activating AMP-activated protein kinase (AMPK) and inhibiting mammalian target of rapamycin (mTOR). aps 0-3 mechanistic target of rapamycin kinase Homo sapiens 123-127 34962345-9 2022 In conclusion, APS reduced reactive oxygen species levels, inhibited apoptosis and pyroptosis, and promoted mitophagy via AMPK/mTOR pathway to alleviate hepatocyte senescence in vitro and in vivo. aps 15-18 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 122-126 34962345-9 2022 In conclusion, APS reduced reactive oxygen species levels, inhibited apoptosis and pyroptosis, and promoted mitophagy via AMPK/mTOR pathway to alleviate hepatocyte senescence in vitro and in vivo. aps 15-18 mechanistic target of rapamycin kinase Homo sapiens 127-131 34976303-8 2021 We found that APS could inhibit the expression level of miR-155 in vivo and in vitro. aps 14-17 microRNA 155 Mus musculus 56-63 34976303-12 2021 APS reduced the secretion of IL-1alpha, TNF-alpha, and C1q by activated microglia, thus inhibited the formation of A1 neurotoxic astrocytes. aps 0-3 interleukin 1 alpha Mus musculus 29-38 34976303-12 2021 APS reduced the secretion of IL-1alpha, TNF-alpha, and C1q by activated microglia, thus inhibited the formation of A1 neurotoxic astrocytes. aps 0-3 tumor necrosis factor Mus musculus 40-49 34976303-12 2021 APS reduced the secretion of IL-1alpha, TNF-alpha, and C1q by activated microglia, thus inhibited the formation of A1 neurotoxic astrocytes. aps 0-3 complement component 1, q subcomponent, alpha polypeptide Mus musculus 55-58 34976303-13 2021 In summary, our study suggests that APS regulates the polarization of microglia from M1 to M2 phenotype by inhibiting the miR-155, reduces the secretion of inflammatory factors, and inhibits the activation of neurotoxic astrocytes, thus effectively treating EAE. aps 36-39 microRNA 155 Mus musculus 122-129 34565296-2 2021 The "classical" role of APs is carried out by AP1-3, which bind to clathrin, cargo, and accessory proteins. aps 24-27 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 46-51 34562641-9 2021 We also found that tdTomato+ APs showed higher expression of Dpp4 and Pi16 than tdTomato- APs, and the expression of these genes was significantly higher in iWAT than gWAT in mice fed HFD for 8 weeks. aps 29-32 dipeptidylpeptidase 4 Mus musculus 61-65 34562641-9 2021 We also found that tdTomato+ APs showed higher expression of Dpp4 and Pi16 than tdTomato- APs, and the expression of these genes was significantly higher in iWAT than gWAT in mice fed HFD for 8 weeks. aps 29-32 peptidase inhibitor 16 Mus musculus 70-74 34726570-5 2021 RESULTS: APS 16 mg/mL treatment enhanced the expression of M1 macrophage markers (iNOS, IL-1beta and TNF-alpha) and M1 macrophage proportions, while reducing the expression of M2 macrophage markers (IL-10, Arg-1) and M2 macrophage proportions in TAMs. aps 9-12 inositol-3-phosphate synthase 1 Homo sapiens 82-86 34726570-5 2021 RESULTS: APS 16 mg/mL treatment enhanced the expression of M1 macrophage markers (iNOS, IL-1beta and TNF-alpha) and M1 macrophage proportions, while reducing the expression of M2 macrophage markers (IL-10, Arg-1) and M2 macrophage proportions in TAMs. aps 9-12 interleukin 1 alpha Homo sapiens 88-96 34726570-5 2021 RESULTS: APS 16 mg/mL treatment enhanced the expression of M1 macrophage markers (iNOS, IL-1beta and TNF-alpha) and M1 macrophage proportions, while reducing the expression of M2 macrophage markers (IL-10, Arg-1) and M2 macrophage proportions in TAMs. aps 9-12 tumor necrosis factor Homo sapiens 101-110 34726570-5 2021 RESULTS: APS 16 mg/mL treatment enhanced the expression of M1 macrophage markers (iNOS, IL-1beta and TNF-alpha) and M1 macrophage proportions, while reducing the expression of M2 macrophage markers (IL-10, Arg-1) and M2 macrophage proportions in TAMs. aps 9-12 interleukin 10 Homo sapiens 199-204 34726570-5 2021 RESULTS: APS 16 mg/mL treatment enhanced the expression of M1 macrophage markers (iNOS, IL-1beta and TNF-alpha) and M1 macrophage proportions, while reducing the expression of M2 macrophage markers (IL-10, Arg-1) and M2 macrophage proportions in TAMs. aps 9-12 arginase 1 Homo sapiens 206-211 34787291-10 2021 Furthermore, the histopathologic examination exhibited that the APS successfully attenuated the changes of myocardial tissues, reduced the lipid accumulation and the protein levels of IL-1beta, TNF-alpha and NF-kappaB. aps 64-67 interleukin 1 alpha Rattus norvegicus 184-192 34787291-10 2021 Furthermore, the histopathologic examination exhibited that the APS successfully attenuated the changes of myocardial tissues, reduced the lipid accumulation and the protein levels of IL-1beta, TNF-alpha and NF-kappaB. aps 64-67 tumor necrosis factor Rattus norvegicus 194-203 34787291-11 2021 Furthermore, the APS could activate the AMPK signaling pathway, enhance the autophagy and suppress the production of ROS. aps 17-20 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 40-44 34787291-12 2021 On conclusions, APS exerted the protective efficacies on overexercise-induced myocardial injury by activating the AMPK signaling pathway to increase autophagy and suppress the inflammation response, oxidative stress, apoptosis of myocardial cells. aps 16-19 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 114-118 34708626-7 2021 Furthermore, ELISA results demonstrated that APS could decrease IL-10 and TGF-beta concentration (P < 0.05). aps 45-48 interleukin 10 Homo sapiens 64-69 34708626-7 2021 Furthermore, ELISA results demonstrated that APS could decrease IL-10 and TGF-beta concentration (P < 0.05). aps 45-48 transforming growth factor alpha Homo sapiens 74-82 34289209-6 2021 Consistent with the changes in MDSCs, the serum level of IL-6, IL-1beta was the lowest in the APS group. aps 94-97 interleukin 1 alpha Mus musculus 63-71 34229016-8 2021 The inhibition of acute UC in mice was correlated with the APs-mediated effects on improving the expression of ZO-1, occludin, Nrf2, HO-I, and NQO1. aps 59-62 tight junction protein 1 Mus musculus 111-115 34229016-8 2021 The inhibition of acute UC in mice was correlated with the APs-mediated effects on improving the expression of ZO-1, occludin, Nrf2, HO-I, and NQO1. aps 59-62 occludin Mus musculus 117-125 34229016-8 2021 The inhibition of acute UC in mice was correlated with the APs-mediated effects on improving the expression of ZO-1, occludin, Nrf2, HO-I, and NQO1. aps 59-62 nuclear factor, erythroid derived 2, like 2 Mus musculus 127-131 34229016-8 2021 The inhibition of acute UC in mice was correlated with the APs-mediated effects on improving the expression of ZO-1, occludin, Nrf2, HO-I, and NQO1. aps 59-62 NAD(P)H dehydrogenase, quinone 1 Mus musculus 143-147 34229016-9 2021 Thus, APs effectively promoted the intestinal barrier via Nrf2/HO-1 signaling pathway and SCFAs metabolism, effectively ameliorating acute colitis in mice. aps 6-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 58-62 34229016-9 2021 Thus, APs effectively promoted the intestinal barrier via Nrf2/HO-1 signaling pathway and SCFAs metabolism, effectively ameliorating acute colitis in mice. aps 6-9 heme oxygenase 1 Mus musculus 63-67 34527718-9 2021 The gene expression levels of interleukin (IL)-2, interleukin (IL)-4, interferon gamma (IFN-gamma), and Toll-like receptor (TLR)-4 were significantly enhanced by APS stimulation at most time points (P < 0.05). aps 162-165 interleukin 15 Gallus gallus 30-48 34527718-9 2021 The gene expression levels of interleukin (IL)-2, interleukin (IL)-4, interferon gamma (IFN-gamma), and Toll-like receptor (TLR)-4 were significantly enhanced by APS stimulation at most time points (P < 0.05). aps 162-165 interleukin 4 Gallus gallus 50-68 34527718-9 2021 The gene expression levels of interleukin (IL)-2, interleukin (IL)-4, interferon gamma (IFN-gamma), and Toll-like receptor (TLR)-4 were significantly enhanced by APS stimulation at most time points (P < 0.05). aps 162-165 interferon gamma Gallus gallus 70-97 34527718-9 2021 The gene expression levels of interleukin (IL)-2, interleukin (IL)-4, interferon gamma (IFN-gamma), and Toll-like receptor (TLR)-4 were significantly enhanced by APS stimulation at most time points (P < 0.05). aps 162-165 toll like receptor 4 Gallus gallus 104-130 34276384-12 2021 APS relieved the LD-induced activation of the intestinal farnesoid X receptor and decreased ileal expression of fibroblast growth factor 15. aps 0-3 fibroblast growth factor 15 Mus musculus 112-139 34291103-14 2021 Reduced expression of COL3A1 in APS treated tendon may indicate superior healing. aps 32-35 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) Equus caballus 22-28 35388305-1 2022 Objective: This study aimed to explore whether astragalus polysaccharides (APS) could treat herpes simplex by increasing tissue-resident memory CD8+ T cells (CD8+ TRM cells) and analyze its potential mechanism using the network pharmacologic approach. aps 75-78 CD8a molecule Homo sapiens 144-147 34258286-6 2021 Thus, in this study, we analyzed APS"s effects on the immune response to ovalbumin in BALB/c mice. aps 33-36 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 73-82 34352784-8 2021 RESULTS: Treatment with high glucose followed by normal glucose significantly upregulated the expression of miR-182 and downregulated the expression of its target Bcl-2, and APS treatment reversed the above effects. aps 174-177 microRNA 182 Homo sapiens 108-115 34352784-10 2021 The effects of APS against mitochondrial damage and apoptosis were partially inhibited after miR-182 overexpression. aps 15-18 microRNA 182 Homo sapiens 93-100 34352784-11 2021 CONCLUSION: APS alleviated mitochondrial damage and apoptosis induced by metabolic memory by regulating the miR-182/Bcl-2 axis, which might serve as a new strategy for the treatment of diabetic retinopathy. aps 12-15 microRNA 182 Homo sapiens 108-115 34352784-11 2021 CONCLUSION: APS alleviated mitochondrial damage and apoptosis induced by metabolic memory by regulating the miR-182/Bcl-2 axis, which might serve as a new strategy for the treatment of diabetic retinopathy. aps 12-15 BCL2 apoptosis regulator Homo sapiens 116-121 35107747-4 2022 In this study, we extracted RAECs from 2-month-old male Wistar rats by the tissue explant method and found that APS ameliorated the high-glucose-induced increase in the frequency of SA-beta-Gal positivity and the levels of the senescence-related proteins p16, p21, and p53. aps 112-115 cyclin-dependent kinase inhibitor 2A Rattus norvegicus 255-258 35107747-4 2022 In this study, we extracted RAECs from 2-month-old male Wistar rats by the tissue explant method and found that APS ameliorated the high-glucose-induced increase in the frequency of SA-beta-Gal positivity and the levels of the senescence-related proteins p16, p21, and p53. aps 112-115 KRAS proto-oncogene, GTPase Rattus norvegicus 260-263 35107747-4 2022 In this study, we extracted RAECs from 2-month-old male Wistar rats by the tissue explant method and found that APS ameliorated the high-glucose-induced increase in the frequency of SA-beta-Gal positivity and the levels of the senescence-related proteins p16, p21, and p53. aps 112-115 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 269-272 35107747-9 2022 Additionally, APS enhanced the levels of autophagy-related proteins (LC3B-II/I, Atg7) and increased the quantity of autophagic vacuoles under high-glucose conditions. aps 14-17 autophagy related 7 Rattus norvegicus 80-84 35585694-9 2022 RESULTS: APS treatment reduced sneezing and rubbing times of AR guinea pigs and suppressed OVA-sIgE, OVA-sIgG1, TNF-alpha, and IL-6 levels in guinea pig serum, and meanwhile, increased CD25+Foxp3+Treg cell proportion while reduced CD4+IL17+Th17 cell proportion in AR guinea pig serum or tissues, in a dose-dependent manner. aps 9-12 tumor necrosis factor Sus scrofa 112-121 35585694-9 2022 RESULTS: APS treatment reduced sneezing and rubbing times of AR guinea pigs and suppressed OVA-sIgE, OVA-sIgG1, TNF-alpha, and IL-6 levels in guinea pig serum, and meanwhile, increased CD25+Foxp3+Treg cell proportion while reduced CD4+IL17+Th17 cell proportion in AR guinea pig serum or tissues, in a dose-dependent manner. aps 9-12 interleukin 6 Sus scrofa 127-131 35585694-9 2022 RESULTS: APS treatment reduced sneezing and rubbing times of AR guinea pigs and suppressed OVA-sIgE, OVA-sIgG1, TNF-alpha, and IL-6 levels in guinea pig serum, and meanwhile, increased CD25+Foxp3+Treg cell proportion while reduced CD4+IL17+Th17 cell proportion in AR guinea pig serum or tissues, in a dose-dependent manner. aps 9-12 interleukin 2 receptor subunit alpha Sus scrofa 185-189 35585694-9 2022 RESULTS: APS treatment reduced sneezing and rubbing times of AR guinea pigs and suppressed OVA-sIgE, OVA-sIgG1, TNF-alpha, and IL-6 levels in guinea pig serum, and meanwhile, increased CD25+Foxp3+Treg cell proportion while reduced CD4+IL17+Th17 cell proportion in AR guinea pig serum or tissues, in a dose-dependent manner. aps 9-12 forkhead box P3 Sus scrofa 190-195 35585694-9 2022 RESULTS: APS treatment reduced sneezing and rubbing times of AR guinea pigs and suppressed OVA-sIgE, OVA-sIgG1, TNF-alpha, and IL-6 levels in guinea pig serum, and meanwhile, increased CD25+Foxp3+Treg cell proportion while reduced CD4+IL17+Th17 cell proportion in AR guinea pig serum or tissues, in a dose-dependent manner. aps 9-12 CD4 molecule Sus scrofa 231-234 35585694-9 2022 RESULTS: APS treatment reduced sneezing and rubbing times of AR guinea pigs and suppressed OVA-sIgE, OVA-sIgG1, TNF-alpha, and IL-6 levels in guinea pig serum, and meanwhile, increased CD25+Foxp3+Treg cell proportion while reduced CD4+IL17+Th17 cell proportion in AR guinea pig serum or tissues, in a dose-dependent manner. aps 9-12 interleukin-17A Sus scrofa 235-239 35575074-6 2022 We found that deletion of Pen-2 neither affected the proliferative capability of APs nor the switch of APs to BPs in the hippocampus, and that it caused enhanced transition of APs to neurons. aps 176-179 presenilin enhancer gamma secretase subunit Mus musculus 26-31 35568216-4 2022 Although the porosity of pristine MDC decreased with functionalization via oxidation, functionalized MDCs (FMDCs), especially FMDC (1.0) that was obtained via treating MDC with APS (1.0 M), showed remarkable performances in the adsorption of small cationic dyes like methylene blue (MB) and azure B. aps 177-180 C-C motif chemokine ligand 22 Homo sapiens 34-37 35568216-4 2022 Although the porosity of pristine MDC decreased with functionalization via oxidation, functionalized MDCs (FMDCs), especially FMDC (1.0) that was obtained via treating MDC with APS (1.0 M), showed remarkable performances in the adsorption of small cationic dyes like methylene blue (MB) and azure B. aps 177-180 C-C motif chemokine ligand 22 Homo sapiens 168-171 35322740-8 2022 In conclusion, APS microbubbles combined with UTMD effectively protect the myocardial injury of DCM rats via activating AMPK signaling pathway to alleviate inflammation response, fibrosis and oxidative stress in myocardial tissues. aps 15-18 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 120-124 35388305-1 2022 Objective: This study aimed to explore whether astragalus polysaccharides (APS) could treat herpes simplex by increasing tissue-resident memory CD8+ T cells (CD8+ TRM cells) and analyze its potential mechanism using the network pharmacologic approach. aps 75-78 CD8a molecule Homo sapiens 158-161 35388305-12 2022 The surface antigens of CD8+ TRM cells had no significant difference between the control group and the model group, while compared with the model group, the surface antigens of CD8 (p < 0.05), CD69 (p < 0.05), and CD103 (p < 0.05) in the APS group increased significantly. aps 238-241 CD8a molecule Homo sapiens 24-27 35388305-13 2022 Moreover, the serum IL-12 (p < 0.05) and IFN-gamma (p < 0.01) levels in the APS group increased significantly compared with the model group. aps 76-79 interferon gamma Mus musculus 41-50 35388305-14 2022 Conclusion: Our study suggested that APS could alleviate the symptoms of the mice infected with HSV-1, and CD8+ TRM cells in the skin lesions and the levels of IL-12 and IFN-gamma in the serum of mice with HSV-1 infection increased after the APS treatment, of which the specific underlying mechanism requires further experiments to clarify. aps 37-40 CD8a molecule Homo sapiens 107-110 35388305-14 2022 Conclusion: Our study suggested that APS could alleviate the symptoms of the mice infected with HSV-1, and CD8+ TRM cells in the skin lesions and the levels of IL-12 and IFN-gamma in the serum of mice with HSV-1 infection increased after the APS treatment, of which the specific underlying mechanism requires further experiments to clarify. aps 37-40 tremor Mus musculus 112-115 35388305-14 2022 Conclusion: Our study suggested that APS could alleviate the symptoms of the mice infected with HSV-1, and CD8+ TRM cells in the skin lesions and the levels of IL-12 and IFN-gamma in the serum of mice with HSV-1 infection increased after the APS treatment, of which the specific underlying mechanism requires further experiments to clarify. aps 37-40 interferon gamma Homo sapiens 170-179 7007160-3 1980 The frequency of pEG1 ampicillin sensitive (Aps) derivatives is about 5.10(-7) and does not depend on the recA gene product. aps 44-47 mesoderm specific transcript Homo sapiens 17-21 35545360-2 2022 The aim of this study is to explore the effect of astragalus polysaccharides (APS) on multidrug resistance gene 1 (MDR1) and P-glycoprotein 170 (P-gp170) in adriamycin nephropathy rats and the underlying mechanisms. aps 78-81 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 115-119 35166175-8 2022 Western blot and cell surface antigen flow cytometry results showed that APS promoted the M2 polarization of rat microglia by inhibiting the expression of purinergic receptor (P2X7R). aps 73-76 CD53 molecule Homo sapiens 17-37 35545360-8 2022 Compared with the high-dose APS group and the APS+miR-16 antagomir control group, there were more severe renal tissue structure damages in the APS + miR-16 antagomir group. aps 143-146 microRNA 16 Rattus norvegicus 149-155 35545360-12 2022 The levels of ALB and miR-16 were significantly decreased in the APS+miR-16 antagomir group compared with the APS+miR-16 antagomir control group (both P<0.05). aps 110-113 microRNA 16 Rattus norvegicus 22-28 35545360-13 2022 CONCLUSIONS: APS can regulate the miR-16/NF-kappaB signaling pathway, thereby affecting the levels of MDR1 and P-gp170, and reducing the inflammation in the kidney tissues in the adriamycin nephropathy rats. aps 13-16 microRNA 16 Rattus norvegicus 34-40 35545360-13 2022 CONCLUSIONS: APS can regulate the miR-16/NF-kappaB signaling pathway, thereby affecting the levels of MDR1 and P-gp170, and reducing the inflammation in the kidney tissues in the adriamycin nephropathy rats. aps 13-16 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 102-106 7007160-7 1980 The other group of Aps-derivatives still possess the property to be eliminated at 43 degrees C and they inhibit the growth of bacterial cells like pEG1. aps 19-22 mesoderm specific transcript Homo sapiens 147-151 33345458-10 2021 Tim4-alphaCD63 showed the highest value for the area under the curve (AUC: 0.957) for discriminating APs from HDs, which should lead to a better understanding of AD pathology and may facilitate the development of a novel diagnostic method for AD. aps 101-104 T cell immunoglobulin and mucin domain containing 4 Homo sapiens 0-4 34008856-8 2021 Meanwhile, the mRNA and protein expression of XPA, XPC, ERCC1, RPA1, and RPA2 were up-regulated significantly in the FA + APS groups (P < 0.05) with the most prominent effect of the 100 mug/mL APS. aps 122-125 XPA, DNA damage recognition and repair factor Homo sapiens 46-49 34008856-8 2021 Meanwhile, the mRNA and protein expression of XPA, XPC, ERCC1, RPA1, and RPA2 were up-regulated significantly in the FA + APS groups (P < 0.05) with the most prominent effect of the 100 mug/mL APS. aps 122-125 XPC complex subunit, DNA damage recognition and repair factor Homo sapiens 51-54 34008856-8 2021 Meanwhile, the mRNA and protein expression of XPA, XPC, ERCC1, RPA1, and RPA2 were up-regulated significantly in the FA + APS groups (P < 0.05) with the most prominent effect of the 100 mug/mL APS. aps 122-125 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 56-61 34008856-8 2021 Meanwhile, the mRNA and protein expression of XPA, XPC, ERCC1, RPA1, and RPA2 were up-regulated significantly in the FA + APS groups (P < 0.05) with the most prominent effect of the 100 mug/mL APS. aps 122-125 replication protein A1 Homo sapiens 63-67 34008856-8 2021 Meanwhile, the mRNA and protein expression of XPA, XPC, ERCC1, RPA1, and RPA2 were up-regulated significantly in the FA + APS groups (P < 0.05) with the most prominent effect of the 100 mug/mL APS. aps 122-125 replication protein A2 Homo sapiens 73-77 34008856-8 2021 Meanwhile, the mRNA and protein expression of XPA, XPC, ERCC1, RPA1, and RPA2 were up-regulated significantly in the FA + APS groups (P < 0.05) with the most prominent effect of the 100 mug/mL APS. aps 193-196 XPA, DNA damage recognition and repair factor Homo sapiens 46-49 34008856-8 2021 Meanwhile, the mRNA and protein expression of XPA, XPC, ERCC1, RPA1, and RPA2 were up-regulated significantly in the FA + APS groups (P < 0.05) with the most prominent effect of the 100 mug/mL APS. aps 193-196 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 56-61 34008856-8 2021 Meanwhile, the mRNA and protein expression of XPA, XPC, ERCC1, RPA1, and RPA2 were up-regulated significantly in the FA + APS groups (P < 0.05) with the most prominent effect of the 100 mug/mL APS. aps 193-196 replication protein A1 Homo sapiens 63-67 34008856-8 2021 Meanwhile, the mRNA and protein expression of XPA, XPC, ERCC1, RPA1, and RPA2 were up-regulated significantly in the FA + APS groups (P < 0.05) with the most prominent effect of the 100 mug/mL APS. aps 193-196 replication protein A2 Homo sapiens 73-77 33952795-9 2021 Moreover, co-administration of Cisplatin and APS was more efficacious for the antitumor effect than either agent alone, as evidenced by the significant decrease in MMP-9 level and increase in p53. aps 45-48 matrix metallopeptidase 9 Homo sapiens 164-169 33952795-9 2021 Moreover, co-administration of Cisplatin and APS was more efficacious for the antitumor effect than either agent alone, as evidenced by the significant decrease in MMP-9 level and increase in p53. aps 45-48 tumor protein p53 Homo sapiens 192-195 33516853-5 2021 Remarkably, the resulting series of PMS particles, especially worm-like PMS-4 APs, and Ag@CS/PMS-4 APs composite film ((Ag@CS/PMS-4 APs)-F) exhibited excellent antibacterial properties, which can be employed as interface materials to prevent the transmission of infectious diseases caused by microorganism contamination. aps 99-102 PMS1 homolog 2, mismatch repair system component pseudogene 2 Homo sapiens 93-98 33516853-5 2021 Remarkably, the resulting series of PMS particles, especially worm-like PMS-4 APs, and Ag@CS/PMS-4 APs composite film ((Ag@CS/PMS-4 APs)-F) exhibited excellent antibacterial properties, which can be employed as interface materials to prevent the transmission of infectious diseases caused by microorganism contamination. aps 99-102 PMS1 homolog 2, mismatch repair system component pseudogene 2 Homo sapiens 93-98 33516853-5 2021 Remarkably, the resulting series of PMS particles, especially worm-like PMS-4 APs, and Ag@CS/PMS-4 APs composite film ((Ag@CS/PMS-4 APs)-F) exhibited excellent antibacterial properties, which can be employed as interface materials to prevent the transmission of infectious diseases caused by microorganism contamination. aps 99-102 PMS1 homolog 2, mismatch repair system component pseudogene 2 Homo sapiens 93-98 33516853-5 2021 Remarkably, the resulting series of PMS particles, especially worm-like PMS-4 APs, and Ag@CS/PMS-4 APs composite film ((Ag@CS/PMS-4 APs)-F) exhibited excellent antibacterial properties, which can be employed as interface materials to prevent the transmission of infectious diseases caused by microorganism contamination. aps 99-102 PMS1 homolog 2, mismatch repair system component pseudogene 2 Homo sapiens 93-98 33704669-8 2022 APS could significantly reduce ROS production and LC3-II and Beclin-1 protein expression, increase the expression of mTOR and the level of antioxidation, and restore the viability and morphological damage of CEF exposed to Cd. aps 0-3 beclin 1 Gallus gallus 61-69 33704669-8 2022 APS could significantly reduce ROS production and LC3-II and Beclin-1 protein expression, increase the expression of mTOR and the level of antioxidation, and restore the viability and morphological damage of CEF exposed to Cd. aps 0-3 mechanistic target of rapamycin Gallus gallus 117-121 33575163-10 2021 Results: In vivo experiments in mice showed that APS can reverse LPS-induced kidney damage in a concentration-dependent manner (P < 0.05); the concentrations of BUN and Scr were increased (all P < 0.05); similarly, the levels of TNF-alpha and IL-1beta were increased as well (all P < 0.05). aps 49-52 tumor necrosis factor Mus musculus 229-238 33680062-6 2021 The activities of superoxide dismutase (SOD) and catalase (CAT) were increased in flies treated with APS diet. aps 101-104 Catalase Drosophila melanogaster 59-62 33680062-7 2021 Moreover, APS significantly enhanced expressions of antioxidant genes (Sod1, Sod2, and Cat), dFoxO, and 4E - BP, decreased the expressions of insulin-like peptides (dilp2, dilp3, and dilp5), and longevity gene MTH. aps 10-13 Superoxide dismutase 1 Drosophila melanogaster 71-75 33680062-7 2021 Moreover, APS significantly enhanced expressions of antioxidant genes (Sod1, Sod2, and Cat), dFoxO, and 4E - BP, decreased the expressions of insulin-like peptides (dilp2, dilp3, and dilp5), and longevity gene MTH. aps 10-13 Superoxide dismutase 2 (Mn) Drosophila melanogaster 77-81 33680062-7 2021 Moreover, APS significantly enhanced expressions of antioxidant genes (Sod1, Sod2, and Cat), dFoxO, and 4E - BP, decreased the expressions of insulin-like peptides (dilp2, dilp3, and dilp5), and longevity gene MTH. aps 10-13 Catalase Drosophila melanogaster 87-90 33680062-7 2021 Moreover, APS significantly enhanced expressions of antioxidant genes (Sod1, Sod2, and Cat), dFoxO, and 4E - BP, decreased the expressions of insulin-like peptides (dilp2, dilp3, and dilp5), and longevity gene MTH. aps 10-13 forkhead box, sub-group O Drosophila melanogaster 93-98 33680062-7 2021 Moreover, APS significantly enhanced expressions of antioxidant genes (Sod1, Sod2, and Cat), dFoxO, and 4E - BP, decreased the expressions of insulin-like peptides (dilp2, dilp3, and dilp5), and longevity gene MTH. aps 10-13 Insulin-like peptide 2 Drosophila melanogaster 165-170 33680062-7 2021 Moreover, APS significantly enhanced expressions of antioxidant genes (Sod1, Sod2, and Cat), dFoxO, and 4E - BP, decreased the expressions of insulin-like peptides (dilp2, dilp3, and dilp5), and longevity gene MTH. aps 10-13 Insulin-like peptide 3 Drosophila melanogaster 172-177 33680062-7 2021 Moreover, APS significantly enhanced expressions of antioxidant genes (Sod1, Sod2, and Cat), dFoxO, and 4E - BP, decreased the expressions of insulin-like peptides (dilp2, dilp3, and dilp5), and longevity gene MTH. aps 10-13 Insulin-like peptide 5 Drosophila melanogaster 183-188 33680062-8 2021 Together, these results indicate that APS can prolong the lifespan by regulating antioxidant ability and insulin/IGF-1 signaling and also enhance the reproduction ability in Drosophila. aps 38-41 Insulin-like receptor Drosophila melanogaster 105-112 33398307-4 2021 To ensure the best anchoring of the reactive functions onto the surface of the droplets, we have designed specific amphiphilic polymers (APs) based on poly(maleic anhydride-alt-1-octadecene), stabilizing the nano-emulsions instead of surfactants. aps 137-140 glutamic--pyruvic transaminase Homo sapiens 173-178 33464816-4 2021 The results showed that after being repaired by APS and Se-APS, HK-2 cells exhibited increased cell viability, restored cell morphology, reduced reactive oxygen species level, increased mitochondrial membrane potential, reduced phosphatidylserine eversion, and osteopontin expression. aps 48-51 secreted phosphoprotein 1 Homo sapiens 261-272 33575163-10 2021 Results: In vivo experiments in mice showed that APS can reverse LPS-induced kidney damage in a concentration-dependent manner (P < 0.05); the concentrations of BUN and Scr were increased (all P < 0.05); similarly, the levels of TNF-alpha and IL-1beta were increased as well (all P < 0.05). aps 49-52 interleukin 1 alpha Mus musculus 243-251 33575163-13 2021 Compared with the LPS group, APS pretreatment could inhibit the expression of inflammatory factors including TNF-alpha, IL-1 beta, IL-6, and IL-8 (all P < 0.05), reducing the number of apoptotic cells (P < 0.05), suppressing the expression of caspase-3, caspase-9, and Bax, but upregulating the expression levels of Bcl-2. aps 29-32 tumor necrosis factor Mus musculus 109-118 33575163-13 2021 Compared with the LPS group, APS pretreatment could inhibit the expression of inflammatory factors including TNF-alpha, IL-1 beta, IL-6, and IL-8 (all P < 0.05), reducing the number of apoptotic cells (P < 0.05), suppressing the expression of caspase-3, caspase-9, and Bax, but upregulating the expression levels of Bcl-2. aps 29-32 interleukin 1 alpha Mus musculus 120-129 33575163-13 2021 Compared with the LPS group, APS pretreatment could inhibit the expression of inflammatory factors including TNF-alpha, IL-1 beta, IL-6, and IL-8 (all P < 0.05), reducing the number of apoptotic cells (P < 0.05), suppressing the expression of caspase-3, caspase-9, and Bax, but upregulating the expression levels of Bcl-2. aps 29-32 interleukin 6 Mus musculus 131-135 33575163-13 2021 Compared with the LPS group, APS pretreatment could inhibit the expression of inflammatory factors including TNF-alpha, IL-1 beta, IL-6, and IL-8 (all P < 0.05), reducing the number of apoptotic cells (P < 0.05), suppressing the expression of caspase-3, caspase-9, and Bax, but upregulating the expression levels of Bcl-2. aps 29-32 chemokine (C-X-C motif) ligand 15 Mus musculus 141-145 33575163-13 2021 Compared with the LPS group, APS pretreatment could inhibit the expression of inflammatory factors including TNF-alpha, IL-1 beta, IL-6, and IL-8 (all P < 0.05), reducing the number of apoptotic cells (P < 0.05), suppressing the expression of caspase-3, caspase-9, and Bax, but upregulating the expression levels of Bcl-2. aps 29-32 caspase 3 Mus musculus 243-252 33575163-13 2021 Compared with the LPS group, APS pretreatment could inhibit the expression of inflammatory factors including TNF-alpha, IL-1 beta, IL-6, and IL-8 (all P < 0.05), reducing the number of apoptotic cells (P < 0.05), suppressing the expression of caspase-3, caspase-9, and Bax, but upregulating the expression levels of Bcl-2. aps 29-32 caspase 9 Mus musculus 254-263 33575163-13 2021 Compared with the LPS group, APS pretreatment could inhibit the expression of inflammatory factors including TNF-alpha, IL-1 beta, IL-6, and IL-8 (all P < 0.05), reducing the number of apoptotic cells (P < 0.05), suppressing the expression of caspase-3, caspase-9, and Bax, but upregulating the expression levels of Bcl-2. aps 29-32 BCL2-associated X protein Mus musculus 269-272 33575163-13 2021 Compared with the LPS group, APS pretreatment could inhibit the expression of inflammatory factors including TNF-alpha, IL-1 beta, IL-6, and IL-8 (all P < 0.05), reducing the number of apoptotic cells (P < 0.05), suppressing the expression of caspase-3, caspase-9, and Bax, but upregulating the expression levels of Bcl-2. aps 29-32 B cell leukemia/lymphoma 2 Mus musculus 316-321 33575163-14 2021 In ERS, APS pretreatment inhibited LPS-induced upregulation of CHOP and GRP78. aps 8-11 DNA-damage inducible transcript 3 Mus musculus 63-67 33575163-14 2021 In ERS, APS pretreatment inhibited LPS-induced upregulation of CHOP and GRP78. aps 8-11 heat shock protein 5 Mus musculus 72-77 33370169-5 2021 We found that APS can alleviate the nasal symptom of AR rats and attenuate pathological alterations. aps 14-17 ferredoxin reductase Rattus norvegicus 53-55 33498389-7 2021 We evaluate our approach in a testbed composed of APs controlled by SD-RAN and SDN controllers, with STAs under different workload combinations. aps 50-53 RAN, member RAS oncogene family Homo sapiens 71-74 33370169-7 2021 APS not only inhibited the NLRP3 inflammasome activation but also inhibited NF-kappaB activation by decreasing NOD2 expression and blocking the phosphorylation of NF-kappaB (p65). aps 0-3 NLR family, pyrin domain containing 3 Rattus norvegicus 27-32 33370169-7 2021 APS not only inhibited the NLRP3 inflammasome activation but also inhibited NF-kappaB activation by decreasing NOD2 expression and blocking the phosphorylation of NF-kappaB (p65). aps 0-3 nucleotide-binding oligomerization domain containing 2 Rattus norvegicus 111-115 33370169-7 2021 APS not only inhibited the NLRP3 inflammasome activation but also inhibited NF-kappaB activation by decreasing NOD2 expression and blocking the phosphorylation of NF-kappaB (p65). aps 0-3 synaptotagmin 1 Rattus norvegicus 174-177 33370169-8 2021 In conclusion, APS can effectively improve the inflammatory symptoms of nasal mucosa in AR rats, which may be mediated by the inhibition of NLRP3 inflammasome activation and NOD2-mediated NF-kappaB activation. aps 15-18 ferredoxin reductase Rattus norvegicus 88-90 33370169-8 2021 In conclusion, APS can effectively improve the inflammatory symptoms of nasal mucosa in AR rats, which may be mediated by the inhibition of NLRP3 inflammasome activation and NOD2-mediated NF-kappaB activation. aps 15-18 NLR family, pyrin domain containing 3 Rattus norvegicus 140-145 33370169-8 2021 In conclusion, APS can effectively improve the inflammatory symptoms of nasal mucosa in AR rats, which may be mediated by the inhibition of NLRP3 inflammasome activation and NOD2-mediated NF-kappaB activation. aps 15-18 nucleotide-binding oligomerization domain containing 2 Rattus norvegicus 174-178 33370169-9 2021 These findings indicate that APS has the potential to be used as a therapeutic agent for AR. aps 29-32 ferredoxin reductase Rattus norvegicus 89-91 33288186-3 2020 In APS-treated rats, acid phosphatase 5 (ACP5) and pro-inflammatory cytokines (TNF-alpha and IL-2) were significantly decreased. aps 3-6 acid phosphatase 5, tartrate resistant Rattus norvegicus 21-39 33368659-1 2021 BACKGROUND: The pathophysiology of heart failure involves maladaptive angiotensin peptides (APs) and enzymes, including angiotensin 2 (AT2) and angiotensin converting enzyme (ACE), as well as recently described alternative components, such as angiotensin 1-7 (Ang1-7) and angiotensin converting enzyme 2 (ACE2). aps 92-95 angiopoietin 1 Canis lupus familiaris 260-266 33368659-1 2021 BACKGROUND: The pathophysiology of heart failure involves maladaptive angiotensin peptides (APs) and enzymes, including angiotensin 2 (AT2) and angiotensin converting enzyme (ACE), as well as recently described alternative components, such as angiotensin 1-7 (Ang1-7) and angiotensin converting enzyme 2 (ACE2). aps 92-95 angiotensin converting enzyme 2 Canis lupus familiaris 272-303 33368659-1 2021 BACKGROUND: The pathophysiology of heart failure involves maladaptive angiotensin peptides (APs) and enzymes, including angiotensin 2 (AT2) and angiotensin converting enzyme (ACE), as well as recently described alternative components, such as angiotensin 1-7 (Ang1-7) and angiotensin converting enzyme 2 (ACE2). aps 92-95 angiotensin converting enzyme 2 Canis lupus familiaris 305-309 33288186-3 2020 In APS-treated rats, acid phosphatase 5 (ACP5) and pro-inflammatory cytokines (TNF-alpha and IL-2) were significantly decreased. aps 3-6 acid phosphatase 5, tartrate resistant Rattus norvegicus 41-45 33288186-3 2020 In APS-treated rats, acid phosphatase 5 (ACP5) and pro-inflammatory cytokines (TNF-alpha and IL-2) were significantly decreased. aps 3-6 tumor necrosis factor Rattus norvegicus 79-88 33288186-3 2020 In APS-treated rats, acid phosphatase 5 (ACP5) and pro-inflammatory cytokines (TNF-alpha and IL-2) were significantly decreased. aps 3-6 interleukin 2 Rattus norvegicus 93-97 33182041-2 2020 This study analyzed the effects of effective antivascular endothelial growth factor (anti-VEGF) antibody production in mice treated with APS. aps 137-140 vascular endothelial growth factor A Mus musculus 90-94 33121344-3 2020 In terms of mechanism, APS up-regulates the proteins Bcl-2, Bcl-xl, and down-regulates the proteins Bax and Bak, which induces a decrease in mitochondrial membrane potential, which induces the release of Cyt-c and AIF, which leads to caspase-dependent and caspase-independent pathway to cause apoptosis. aps 23-26 BCL2 apoptosis regulator Homo sapiens 53-58 33121344-3 2020 In terms of mechanism, APS up-regulates the proteins Bcl-2, Bcl-xl, and down-regulates the proteins Bax and Bak, which induces a decrease in mitochondrial membrane potential, which induces the release of Cyt-c and AIF, which leads to caspase-dependent and caspase-independent pathway to cause apoptosis. aps 23-26 BCL2 like 1 Homo sapiens 60-66 33121344-3 2020 In terms of mechanism, APS up-regulates the proteins Bcl-2, Bcl-xl, and down-regulates the proteins Bax and Bak, which induces a decrease in mitochondrial membrane potential, which induces the release of Cyt-c and AIF, which leads to caspase-dependent and caspase-independent pathway to cause apoptosis. aps 23-26 BCL2 associated X, apoptosis regulator Homo sapiens 100-103 33121344-3 2020 In terms of mechanism, APS up-regulates the proteins Bcl-2, Bcl-xl, and down-regulates the proteins Bax and Bak, which induces a decrease in mitochondrial membrane potential, which induces the release of Cyt-c and AIF, which leads to caspase-dependent and caspase-independent pathway to cause apoptosis. aps 23-26 BCL2 antagonist/killer 1 Homo sapiens 108-111 33121344-3 2020 In terms of mechanism, APS up-regulates the proteins Bcl-2, Bcl-xl, and down-regulates the proteins Bax and Bak, which induces a decrease in mitochondrial membrane potential, which induces the release of Cyt-c and AIF, which leads to caspase-dependent and caspase-independent pathway to cause apoptosis. aps 23-26 apoptosis inducing factor mitochondria associated 1 Homo sapiens 214-217 33182041-3 2020 After APS treatment, the serum of mice produced the antibody reactions that can cross-validate VEGF. aps 6-9 vascular endothelial growth factor A Mus musculus 95-99 32387604-1 2020 As an immune-regulator, Astragalus polysaccharides (APS) could effectively modulate the activity of toll-like receptor 4 (TLR4) signaling pathway, and induce anti-inflammatory response in intestinal. aps 52-55 toll like receptor 4 Homo sapiens 100-120 32557888-4 2020 Moreover, in ovo administration of live NDV vaccine plus APS could significantly enhance the serum anti-NDV antibody titres and interferon gamma (IFN-gamma), interleukin (IL)-2, IL-4 and IL-6 concentrations, promote lymphocyte proliferative capability as well as improve the frequencies of CD4+ and CD8+ T cells in peripheral blood. aps 57-60 interferon gamma Homo sapiens 128-155 32557888-4 2020 Moreover, in ovo administration of live NDV vaccine plus APS could significantly enhance the serum anti-NDV antibody titres and interferon gamma (IFN-gamma), interleukin (IL)-2, IL-4 and IL-6 concentrations, promote lymphocyte proliferative capability as well as improve the frequencies of CD4+ and CD8+ T cells in peripheral blood. aps 57-60 interleukin 2 Homo sapiens 158-176 32557888-4 2020 Moreover, in ovo administration of live NDV vaccine plus APS could significantly enhance the serum anti-NDV antibody titres and interferon gamma (IFN-gamma), interleukin (IL)-2, IL-4 and IL-6 concentrations, promote lymphocyte proliferative capability as well as improve the frequencies of CD4+ and CD8+ T cells in peripheral blood. aps 57-60 interleukin 4 Homo sapiens 178-182 32557888-4 2020 Moreover, in ovo administration of live NDV vaccine plus APS could significantly enhance the serum anti-NDV antibody titres and interferon gamma (IFN-gamma), interleukin (IL)-2, IL-4 and IL-6 concentrations, promote lymphocyte proliferative capability as well as improve the frequencies of CD4+ and CD8+ T cells in peripheral blood. aps 57-60 interleukin 6 Homo sapiens 187-191 32557888-4 2020 Moreover, in ovo administration of live NDV vaccine plus APS could significantly enhance the serum anti-NDV antibody titres and interferon gamma (IFN-gamma), interleukin (IL)-2, IL-4 and IL-6 concentrations, promote lymphocyte proliferative capability as well as improve the frequencies of CD4+ and CD8+ T cells in peripheral blood. aps 57-60 CD4 molecule Homo sapiens 290-293 32557888-4 2020 Moreover, in ovo administration of live NDV vaccine plus APS could significantly enhance the serum anti-NDV antibody titres and interferon gamma (IFN-gamma), interleukin (IL)-2, IL-4 and IL-6 concentrations, promote lymphocyte proliferative capability as well as improve the frequencies of CD4+ and CD8+ T cells in peripheral blood. aps 57-60 CD8a molecule Homo sapiens 299-302 33021613-5 2020 The receptor blocking assay showed that TLR4 was the primary receptor involved in APS-mediated B cell activation, which was confirmed by the results obtained using C57BL/10ScNJ (TLR4 gene-deficient) mice. aps 82-85 toll-like receptor 4 Mus musculus 40-44 33021613-5 2020 The receptor blocking assay showed that TLR4 was the primary receptor involved in APS-mediated B cell activation, which was confirmed by the results obtained using C57BL/10ScNJ (TLR4 gene-deficient) mice. aps 82-85 toll-like receptor 4 Mus musculus 178-182 33021613-6 2020 Moreover, APS activated the TLR4-MyD88 signaling pathway at the translational level by significantly increasing the protein expression of TLR4 and MyD88. aps 10-13 toll-like receptor 4 Mus musculus 28-32 33021613-6 2020 Moreover, APS activated the TLR4-MyD88 signaling pathway at the translational level by significantly increasing the protein expression of TLR4 and MyD88. aps 10-13 toll-like receptor 4 Mus musculus 138-142 33021613-9 2020 Therefore, we concluded that APS specifically activates the immune functions of splenic B cells by TLR4, acting through the MAPK and NF-kappaB signaling pathways, and potently activates the p38 pathway. aps 29-32 toll-like receptor 4 Mus musculus 99-103 32800555-4 2020 APS treatment significantly increased the expression of Nrf2 in the nucleus but decreased its expression in the cytoplasm, and restored the expression levels of Keap1, SOD, GSH-Px and MDA. aps 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 56-60 32800555-4 2020 APS treatment significantly increased the expression of Nrf2 in the nucleus but decreased its expression in the cytoplasm, and restored the expression levels of Keap1, SOD, GSH-Px and MDA. aps 0-3 kelch-like ECH-associated protein 1 Mus musculus 161-166 32800555-5 2020 When APP/PS1 mice were treated with APS and injected with Nrf2 siRNA, the down-regulation of Nrf2 expression significantly blocked the regulation of APS on oxidative stress. aps 36-39 presenilin 1 Mus musculus 9-12 32800555-5 2020 When APP/PS1 mice were treated with APS and injected with Nrf2 siRNA, the down-regulation of Nrf2 expression significantly blocked the regulation of APS on oxidative stress. aps 36-39 nuclear factor, erythroid derived 2, like 2 Mus musculus 93-97 32800555-5 2020 When APP/PS1 mice were treated with APS and injected with Nrf2 siRNA, the down-regulation of Nrf2 expression significantly blocked the regulation of APS on oxidative stress. aps 149-152 presenilin 1 Mus musculus 9-12 32800555-5 2020 When APP/PS1 mice were treated with APS and injected with Nrf2 siRNA, the down-regulation of Nrf2 expression significantly blocked the regulation of APS on oxidative stress. aps 149-152 nuclear factor, erythroid derived 2, like 2 Mus musculus 58-62 32800555-5 2020 When APP/PS1 mice were treated with APS and injected with Nrf2 siRNA, the down-regulation of Nrf2 expression significantly blocked the regulation of APS on oxidative stress. aps 149-152 nuclear factor, erythroid derived 2, like 2 Mus musculus 93-97 32800555-7 2020 APS treatment significantly improved the cognitive ability of APP/PS1 mice, reduced apoptosis and the accumulation of Abeta, but the above effects of APS were blocked by Nrf2 siRNA injection. aps 0-3 presenilin 1 Mus musculus 66-69 32800555-7 2020 APS treatment significantly improved the cognitive ability of APP/PS1 mice, reduced apoptosis and the accumulation of Abeta, but the above effects of APS were blocked by Nrf2 siRNA injection. aps 0-3 amyloid beta (A4) precursor protein Mus musculus 118-123 32800555-7 2020 APS treatment significantly improved the cognitive ability of APP/PS1 mice, reduced apoptosis and the accumulation of Abeta, but the above effects of APS were blocked by Nrf2 siRNA injection. aps 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 170-174 32800555-7 2020 APS treatment significantly improved the cognitive ability of APP/PS1 mice, reduced apoptosis and the accumulation of Abeta, but the above effects of APS were blocked by Nrf2 siRNA injection. aps 150-153 nuclear factor, erythroid derived 2, like 2 Mus musculus 170-174 32800555-8 2020 Therefore, APS can activate Nrf2 pathway to improve the physiological function of AD mice, which may have important clinical application value. aps 11-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 28-32 32387604-1 2020 As an immune-regulator, Astragalus polysaccharides (APS) could effectively modulate the activity of toll-like receptor 4 (TLR4) signaling pathway, and induce anti-inflammatory response in intestinal. aps 52-55 toll like receptor 4 Homo sapiens 122-126 32387604-8 2020 Above all, we concluded that APS could antagonize the LPS induced inflammatory response by a TRIF-dependent manner. aps 29-32 TIR domain containing adaptor molecule 1 Homo sapiens 93-97 32112840-5 2020 Moreover, APS could down-regulate the expression of pAKT and pmTOR, and up-regulate the expression of PTEN. aps 10-13 phosphatase and tensin homolog Rattus norvegicus 102-106 32319542-8 2020 Furthermore, APS significantly inhibited the epithelial-mesenchymal transition (EMT), as evidenced by an increased level of E-cadherin and a decreased expression of vimentin and alpha smooth muscle actin. aps 13-16 cadherin 1 Mus musculus 124-134 32319542-8 2020 Furthermore, APS significantly inhibited the epithelial-mesenchymal transition (EMT), as evidenced by an increased level of E-cadherin and a decreased expression of vimentin and alpha smooth muscle actin. aps 13-16 vimentin Mus musculus 165-173 32319542-9 2020 Furthermore, APS treatment significantly decreased TGF-beta1-induced EMT and NF-kappaB pathway activation in vitro. aps 13-16 transforming growth factor, beta 1 Mus musculus 51-60 32319542-9 2020 Furthermore, APS treatment significantly decreased TGF-beta1-induced EMT and NF-kappaB pathway activation in vitro. aps 13-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 77-86 32671108-10 2020 Treatment with ACS and APS caused a trend in upregulation of IL-10 expression in synovium and type II collagen and aggrecan expression in cartilage. aps 23-26 interleukin 10 Equus caballus 61-66 32671108-10 2020 Treatment with ACS and APS caused a trend in upregulation of IL-10 expression in synovium and type II collagen and aggrecan expression in cartilage. aps 23-26 collagen type II alpha 1 chain Equus caballus 94-110 32112840-7 2020 Results showed that these events regulated by APS were reversed in PI3K KD cells, shown that APS activated autophagy through PI3K/AKT/mTOR pathway for treating PD. aps 46-49 AKT serine/threonine kinase 1 Rattus norvegicus 130-133 32112840-7 2020 Results showed that these events regulated by APS were reversed in PI3K KD cells, shown that APS activated autophagy through PI3K/AKT/mTOR pathway for treating PD. aps 46-49 mechanistic target of rapamycin kinase Rattus norvegicus 134-138 32112840-7 2020 Results showed that these events regulated by APS were reversed in PI3K KD cells, shown that APS activated autophagy through PI3K/AKT/mTOR pathway for treating PD. aps 93-96 AKT serine/threonine kinase 1 Rattus norvegicus 130-133 32112840-7 2020 Results showed that these events regulated by APS were reversed in PI3K KD cells, shown that APS activated autophagy through PI3K/AKT/mTOR pathway for treating PD. aps 93-96 mechanistic target of rapamycin kinase Rattus norvegicus 134-138 32112840-8 2020 Altogether, APS has the role of increasing autophagy, and this event was responsible for inhibiting PI3K protein to activate PI3K/AKT/mTOR pathway. aps 12-15 AKT serine/threonine kinase 1 Rattus norvegicus 130-133 32112840-8 2020 Altogether, APS has the role of increasing autophagy, and this event was responsible for inhibiting PI3K protein to activate PI3K/AKT/mTOR pathway. aps 12-15 mechanistic target of rapamycin kinase Rattus norvegicus 134-138 32431616-5 2020 Microarray data revealed the SIRT1 expression was markably suppressed under APS exposure. aps 76-79 sirtuin 1 Homo sapiens 29-34 32509166-11 2020 Moreover, APS increased expression of E-cadherin and decreased expression of N-cadherin and vimentin, indicating that it may be related to inhibition of the PD-L1/SREBP-1/EMT signaling pathway. aps 10-13 cadherin 1 Homo sapiens 38-48 32509166-11 2020 Moreover, APS increased expression of E-cadherin and decreased expression of N-cadherin and vimentin, indicating that it may be related to inhibition of the PD-L1/SREBP-1/EMT signaling pathway. aps 10-13 cadherin 2 Homo sapiens 77-87 32509166-11 2020 Moreover, APS increased expression of E-cadherin and decreased expression of N-cadherin and vimentin, indicating that it may be related to inhibition of the PD-L1/SREBP-1/EMT signaling pathway. aps 10-13 vimentin Homo sapiens 92-100 32509166-11 2020 Moreover, APS increased expression of E-cadherin and decreased expression of N-cadherin and vimentin, indicating that it may be related to inhibition of the PD-L1/SREBP-1/EMT signaling pathway. aps 10-13 CD274 molecule Homo sapiens 157-162 32509166-11 2020 Moreover, APS increased expression of E-cadherin and decreased expression of N-cadherin and vimentin, indicating that it may be related to inhibition of the PD-L1/SREBP-1/EMT signaling pathway. aps 10-13 sterol regulatory element binding transcription factor 1 Homo sapiens 163-170 32509166-12 2020 Based on these findings, it can be concluded that APS can reverse acquired resistance to gefitinib in lung cancer cells by inhibiting the PD-L1/SREBP-1/EMT signaling pathway. aps 50-53 CD274 molecule Homo sapiens 138-143 32509166-12 2020 Based on these findings, it can be concluded that APS can reverse acquired resistance to gefitinib in lung cancer cells by inhibiting the PD-L1/SREBP-1/EMT signaling pathway. aps 50-53 sterol regulatory element binding transcription factor 1 Homo sapiens 144-151 32431616-9 2020 To summarize, our findings suggested that APS inhibits tumorigenesis and lipid metabolism through miR-138-5p/SIRT1/SREBP1 pathways in PCa. aps 42-45 sirtuin 1 Homo sapiens 109-114 32431616-9 2020 To summarize, our findings suggested that APS inhibits tumorigenesis and lipid metabolism through miR-138-5p/SIRT1/SREBP1 pathways in PCa. aps 42-45 sterol regulatory element binding transcription factor 1 Homo sapiens 115-121 32256349-7 2020 In vitro release showed that 67.48-93.76% APS was released from APS/CTS microspheres at pH 6.8 within 24 h. The effects showed that APS/CTS microspheres alleviated allergic symptoms and reduced eosinophils infiltration and the expression of interleukin-4 in the nasal mucosa tissue of rats that had no liver and kidney toxicity by hematoxylin-eosin staining observation. aps 42-45 interleukin 4 Rattus norvegicus 241-254 32256349-7 2020 In vitro release showed that 67.48-93.76% APS was released from APS/CTS microspheres at pH 6.8 within 24 h. The effects showed that APS/CTS microspheres alleviated allergic symptoms and reduced eosinophils infiltration and the expression of interleukin-4 in the nasal mucosa tissue of rats that had no liver and kidney toxicity by hematoxylin-eosin staining observation. aps 64-67 interleukin 4 Rattus norvegicus 241-254 32256349-7 2020 In vitro release showed that 67.48-93.76% APS was released from APS/CTS microspheres at pH 6.8 within 24 h. The effects showed that APS/CTS microspheres alleviated allergic symptoms and reduced eosinophils infiltration and the expression of interleukin-4 in the nasal mucosa tissue of rats that had no liver and kidney toxicity by hematoxylin-eosin staining observation. aps 64-67 interleukin 4 Rattus norvegicus 241-254 31504280-5 2020 Here, we report that conditional deletion of phoshpoinositide-dependent protein kinase 1 (PDK1) in mouse developing cortex achieved by crossing Emx1Cre line with Pdk1fl/fl leads to a delayed transition of APs to BPs and subsequently causes an increased output of deeper-layer neurons. aps 205-208 pyruvate dehydrogenase kinase, isoenzyme 1 Mus musculus 45-88 31669273-7 2020 Furthermore, APS was capable of up-regulating the expression of IL-2, TNF-alpha and IFN-gamma in peripheral blood. aps 13-16 interleukin 2 Mus musculus 64-68 31669273-7 2020 Furthermore, APS was capable of up-regulating the expression of IL-2, TNF-alpha and IFN-gamma in peripheral blood. aps 13-16 tumor necrosis factor Mus musculus 70-79 31669273-7 2020 Furthermore, APS was capable of up-regulating the expression of IL-2, TNF-alpha and IFN-gamma in peripheral blood. aps 13-16 interferon gamma Mus musculus 84-93 31894851-11 2020 Pre-treatment with APS concentration-dependently reversed miR-204 expression, leading to disinhibition of SIRT1 and alleviation of ER stress-induced apoptosis indicated by decreased levels of p-PERK, p-IRE-1, cleaved-ATF6, Bax, cleaved caspase-12, -9, -3, and increased levels of Bcl-2 and unleaved PARP. aps 19-22 microRNA 204 Homo sapiens 58-65 31894851-11 2020 Pre-treatment with APS concentration-dependently reversed miR-204 expression, leading to disinhibition of SIRT1 and alleviation of ER stress-induced apoptosis indicated by decreased levels of p-PERK, p-IRE-1, cleaved-ATF6, Bax, cleaved caspase-12, -9, -3, and increased levels of Bcl-2 and unleaved PARP. aps 19-22 sirtuin 1 Homo sapiens 106-111 31894851-11 2020 Pre-treatment with APS concentration-dependently reversed miR-204 expression, leading to disinhibition of SIRT1 and alleviation of ER stress-induced apoptosis indicated by decreased levels of p-PERK, p-IRE-1, cleaved-ATF6, Bax, cleaved caspase-12, -9, -3, and increased levels of Bcl-2 and unleaved PARP. aps 19-22 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 194-198 31894851-11 2020 Pre-treatment with APS concentration-dependently reversed miR-204 expression, leading to disinhibition of SIRT1 and alleviation of ER stress-induced apoptosis indicated by decreased levels of p-PERK, p-IRE-1, cleaved-ATF6, Bax, cleaved caspase-12, -9, -3, and increased levels of Bcl-2 and unleaved PARP. aps 19-22 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 202-207 31894851-11 2020 Pre-treatment with APS concentration-dependently reversed miR-204 expression, leading to disinhibition of SIRT1 and alleviation of ER stress-induced apoptosis indicated by decreased levels of p-PERK, p-IRE-1, cleaved-ATF6, Bax, cleaved caspase-12, -9, -3, and increased levels of Bcl-2 and unleaved PARP. aps 19-22 activating transcription factor 6 Homo sapiens 217-221 31894851-11 2020 Pre-treatment with APS concentration-dependently reversed miR-204 expression, leading to disinhibition of SIRT1 and alleviation of ER stress-induced apoptosis indicated by decreased levels of p-PERK, p-IRE-1, cleaved-ATF6, Bax, cleaved caspase-12, -9, -3, and increased levels of Bcl-2 and unleaved PARP. aps 19-22 BCL2 associated X, apoptosis regulator Homo sapiens 223-226 31894851-11 2020 Pre-treatment with APS concentration-dependently reversed miR-204 expression, leading to disinhibition of SIRT1 and alleviation of ER stress-induced apoptosis indicated by decreased levels of p-PERK, p-IRE-1, cleaved-ATF6, Bax, cleaved caspase-12, -9, -3, and increased levels of Bcl-2 and unleaved PARP. aps 19-22 caspase 9 Homo sapiens 236-254 31894851-11 2020 Pre-treatment with APS concentration-dependently reversed miR-204 expression, leading to disinhibition of SIRT1 and alleviation of ER stress-induced apoptosis indicated by decreased levels of p-PERK, p-IRE-1, cleaved-ATF6, Bax, cleaved caspase-12, -9, -3, and increased levels of Bcl-2 and unleaved PARP. aps 19-22 BCL2 apoptosis regulator Homo sapiens 280-285 31894851-11 2020 Pre-treatment with APS concentration-dependently reversed miR-204 expression, leading to disinhibition of SIRT1 and alleviation of ER stress-induced apoptosis indicated by decreased levels of p-PERK, p-IRE-1, cleaved-ATF6, Bax, cleaved caspase-12, -9, -3, and increased levels of Bcl-2 and unleaved PARP. aps 19-22 collagen type XI alpha 2 chain Homo sapiens 299-303 31894851-12 2020 The effects of APS on RPE cells were reversed by either miR-204 overexpression or SIRT1 knockdown. aps 15-18 microRNA 204 Homo sapiens 56-63 31894851-12 2020 The effects of APS on RPE cells were reversed by either miR-204 overexpression or SIRT1 knockdown. aps 15-18 sirtuin 1 Homo sapiens 82-87 31894851-13 2020 CONCLUSIONS: We concluded that APS inhibited ER stress and subsequent apoptosis via regulating miR-204/SIRT1 axis in metabolic memory model of RPE cells. aps 31-34 microRNA 204 Homo sapiens 95-102 31894851-13 2020 CONCLUSIONS: We concluded that APS inhibited ER stress and subsequent apoptosis via regulating miR-204/SIRT1 axis in metabolic memory model of RPE cells. aps 31-34 sirtuin 1 Homo sapiens 103-108 31504280-5 2020 Here, we report that conditional deletion of phoshpoinositide-dependent protein kinase 1 (PDK1) in mouse developing cortex achieved by crossing Emx1Cre line with Pdk1fl/fl leads to a delayed transition of APs to BPs and subsequently causes an increased output of deeper-layer neurons. aps 205-208 pyruvate dehydrogenase kinase, isoenzyme 1 Mus musculus 90-94 31504280-5 2020 Here, we report that conditional deletion of phoshpoinositide-dependent protein kinase 1 (PDK1) in mouse developing cortex achieved by crossing Emx1Cre line with Pdk1fl/fl leads to a delayed transition of APs to BPs and subsequently causes an increased output of deeper-layer neurons. aps 205-208 pyruvate dehydrogenase kinase, isoenzyme 1 Mus musculus 162-166 31504280-9 2020 Thus, we have identified a novel function of PDK1 in controlling the transition of APs to BPs. aps 83-86 pyruvate dehydrogenase kinase, isoenzyme 1 Mus musculus 45-49 31933514-6 2020 RESULTS: The treatments of salazopyrine, APS, matrine, and APS combined with matrine reduced DAI scores and improved histopathological changes of colon and lung tissues, as well as decreased CMDI scores, ET levels, and DAO activities in UC rats. aps 59-62 amine oxidase, copper containing 1 Rattus norvegicus 219-222 31933514-10 2020 CONCLUSION: APS combined with matrine exert a synergistic protective effect against UC and lung injury, which might be associated with regulating TFF3 expression. aps 12-15 trefoil factor 3 Rattus norvegicus 146-150 31159593-6 2019 The functions of KLF2 in APS and H2O2 co-disposed HUVECs were explored after si-KLF2 transfection. aps 25-28 Kruppel like factor 2 Homo sapiens 17-21 31159593-10 2019 KLF2 and Nrf2 expression were elevated by APS and KLF2 repression abolished the protective action of APS in H2O2-triggered cell injury. aps 42-45 Kruppel like factor 2 Homo sapiens 0-4 31159593-10 2019 KLF2 and Nrf2 expression were elevated by APS and KLF2 repression abolished the protective action of APS in H2O2-triggered cell injury. aps 42-45 NFE2 like bZIP transcription factor 2 Homo sapiens 9-13 31159593-12 2019 Furthermore, the MEK/ERK pathway inhibitor weakened the promoting effect of APS on the expression of KLF2. aps 76-79 mitogen-activated protein kinase kinase 7 Homo sapiens 17-20 31159593-12 2019 Furthermore, the MEK/ERK pathway inhibitor weakened the promoting effect of APS on the expression of KLF2. aps 76-79 mitogen-activated protein kinase 1 Homo sapiens 21-24 31159593-12 2019 Furthermore, the MEK/ERK pathway inhibitor weakened the promoting effect of APS on the expression of KLF2. aps 76-79 Kruppel like factor 2 Homo sapiens 101-105 31159593-13 2019 In conclusion, our study reveals that APS alleviates H2O2-triggered oxidative injury in HUVECs via elevating the expression of KLF2 via the MEK/ERK pathway. aps 38-41 Kruppel like factor 2 Homo sapiens 127-131 31159593-13 2019 In conclusion, our study reveals that APS alleviates H2O2-triggered oxidative injury in HUVECs via elevating the expression of KLF2 via the MEK/ERK pathway. aps 38-41 mitogen-activated protein kinase kinase 7 Homo sapiens 140-143 31159593-13 2019 In conclusion, our study reveals that APS alleviates H2O2-triggered oxidative injury in HUVECs via elevating the expression of KLF2 via the MEK/ERK pathway. aps 38-41 mitogen-activated protein kinase 1 Homo sapiens 144-147