PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9990657-8	1998	or VIP antagonist (Ac-Tyr1, D-Phe2-VIP: 40 nmol kg-1, i.v.).	d-phe2	28-34	vasoactive intestinal peptide	Rattus norvegicus	35-38
10067871-5	1999	In static cultures of hypothalamic neurons and GT1-7 cells, treatment with the GnRH receptor antagonist, [D-pGlu1, D-Phe2, D-Trp(3,6)]GnRH caused a prominent increase in GnRH release.	d-phe2	115-121	gonadotropin releasing hormone receptor	Mus musculus	79-92
10668641-5	1999	When GnRH antagonist ([D-pGlu1, D-Phe2, D-Trp3,6]-LH-RH) was added to the cultures together with GnRH (0.2 nM) for 6 h, the stimulatory effect of GnRH on GnRH-R mRNA levels and LH release was significantly diminished in a dose-related manner.	d-phe2	32-38	gonadotropin releasing hormone 1	Rattus norvegicus	5-9
9639281-8	1998	The stimulatory effects of VIP and PACAP were similarly inhibited by the VIP1/PACAP antagonist [acetyl-His1, D-Phe2, K15, R16, L27]VIP(3-7)/growth hormone releasing factor(8-27).	d-phe2	109-115	adenylate cyclase activating polypeptide 1	Rattus norvegicus	78-83
9687317-5	1998	Sperm were also incubated with the GnRH antagonist Ac-3,4-dehydro-Pro1, -p-fluoro-<FONT SIZE=-1>D-Phe2, <FONT SIZE=-1>D-Trp3,6-LHRH, alone or before adding GnRH.	d-phe2	102-108	lamin A/C	Homo sapiens	66-70
9639281-8	1998	The stimulatory effects of VIP and PACAP were similarly inhibited by the VIP1/PACAP antagonist [acetyl-His1, D-Phe2, K15, R16, L27]VIP(3-7)/growth hormone releasing factor(8-27).	d-phe2	109-115	vasoactive intestinal peptide	Rattus norvegicus	27-30
9406917-2	1997	Treatment of GT1-1 cells with buserelin, a GnRH agonist, or native GnRH for 24 h significantly decreased GnRH promoter activity and its mRNA level, whereas that with GnRH antagonists, antide or [D-Phe2,D-Ala6]-GnRH, showed no effect.	d-phe2	195-201	gonadotropin releasing hormone 1	Mus musculus	67-71
9639281-8	1998	The stimulatory effects of VIP and PACAP were similarly inhibited by the VIP1/PACAP antagonist [acetyl-His1, D-Phe2, K15, R16, L27]VIP(3-7)/growth hormone releasing factor(8-27).	d-phe2	109-115	adenylate cyclase activating polypeptide 1	Rattus norvegicus	35-40
9639281-8	1998	The stimulatory effects of VIP and PACAP were similarly inhibited by the VIP1/PACAP antagonist [acetyl-His1, D-Phe2, K15, R16, L27]VIP(3-7)/growth hormone releasing factor(8-27).	d-phe2	109-115	vasoactive intestinal peptide	Rattus norvegicus	73-76
9639281-8	1998	The stimulatory effects of VIP and PACAP were similarly inhibited by the VIP1/PACAP antagonist [acetyl-His1, D-Phe2, K15, R16, L27]VIP(3-7)/growth hormone releasing factor(8-27).	d-phe2	109-115	growth hormone releasing hormone	Rattus norvegicus	140-171
9406917-2	1997	Treatment of GT1-1 cells with buserelin, a GnRH agonist, or native GnRH for 24 h significantly decreased GnRH promoter activity and its mRNA level, whereas that with GnRH antagonists, antide or [D-Phe2,D-Ala6]-GnRH, showed no effect.	d-phe2	195-201	gonadotropin releasing hormone 1	Mus musculus	67-71
9406917-2	1997	Treatment of GT1-1 cells with buserelin, a GnRH agonist, or native GnRH for 24 h significantly decreased GnRH promoter activity and its mRNA level, whereas that with GnRH antagonists, antide or [D-Phe2,D-Ala6]-GnRH, showed no effect.	d-phe2	195-201	gonadotropin releasing hormone 1	Mus musculus	67-71
9406917-2	1997	Treatment of GT1-1 cells with buserelin, a GnRH agonist, or native GnRH for 24 h significantly decreased GnRH promoter activity and its mRNA level, whereas that with GnRH antagonists, antide or [D-Phe2,D-Ala6]-GnRH, showed no effect.	d-phe2	195-201	gonadotropin releasing hormone 1	Mus musculus	67-71
7679135-7	1993	The mitogenic effects of SP were abrogated by the SP antagonist spantide and those of VIP by the VIP antagonist [Ac-Tyr1, D-Phe2] growth-hormone-releasing factor (1-29) amide.	d-phe2	122-128	vasoactive intestinal peptide	Homo sapiens	86-89
9197276-3	1997	Responses of the identified neurons to the microiontophoresis of gonadotropin-releasing hormone (GnRH) or D-Phe2, D-Ala6-GnRH, a behaviorally active analog, but not to glutamate or gamma-aminobutyric acid (GABA), depended on estrogen.	d-phe2	106-112	gonadotropin releasing hormone 1	Rattus norvegicus	121-125
7679135-7	1993	The mitogenic effects of SP were abrogated by the SP antagonist spantide and those of VIP by the VIP antagonist [Ac-Tyr1, D-Phe2] growth-hormone-releasing factor (1-29) amide.	d-phe2	122-128	vasoactive intestinal peptide	Homo sapiens	97-100
1717103-10	1991	In contrast, the vasoactive intestinal peptide (VIP) antagonist (N-Ac-Tyr1,D-Phe2)-GRF (1-29)-NH2 blocked morphine-induced reflex facilitation in axotomized rats, but not in rats with intact nerves.	d-phe2	75-81	vasoactive intestinal peptide	Rattus norvegicus	48-51
1481892-9	1992	Phentolamine and adrenalectomy eliminated the hindquarters pressor response to PACAP and D-Phe2-VIP, a VIP antagonist, reduced responses to VIP but not to PACAP.	d-phe2	89-95	vasoactive intestinal peptide	Homo sapiens	96-99
1481892-9	1992	Phentolamine and adrenalectomy eliminated the hindquarters pressor response to PACAP and D-Phe2-VIP, a VIP antagonist, reduced responses to VIP but not to PACAP.	d-phe2	89-95	vasoactive intestinal peptide	Homo sapiens	103-106
1481892-9	1992	Phentolamine and adrenalectomy eliminated the hindquarters pressor response to PACAP and D-Phe2-VIP, a VIP antagonist, reduced responses to VIP but not to PACAP.	d-phe2	89-95	vasoactive intestinal peptide	Homo sapiens	103-106
2904377-5	1988	LHRH caused a rapid increase in [Ca2+]i by about 50 nM which was blocked by the LHRH antagonist, [D-pGlu1,D-Phe2,D-Trp3,6] LHRH.	d-phe2	106-112	gonadotropin releasing hormone 1	Rattus norvegicus	0-4
2156987-7	1990	Three putative "tissue selective" BK antagonists, d-Phe2,7-BK (B4404), d-Phe7-Hyp8-BK and Phe2-d-Phe7-BK also had an agonistic effect on longitudinal muscle.	d-phe2	50-56	kininogen 1	Homo sapiens	34-36
2561912-10	1989	(D-Phe2)VIP, VIP[10-28], VIP[16-28], and (p-Cl-D-Phe6, Leu17)VIP, a putative VIP receptor antagonist, affected neither basal cAMP levels nor hVIP-induced cAMP accumulation.	d-phe2	1-7	vasoactive intestinal peptide	Homo sapiens	8-11
1965033-5	1990	The binding of 125I-VIP could be completely inhibited by 10 mumol/l of the antagonists [N-Ac-Tyr1,D-Phe2]GRF(1-29)-NH2, [pCl-D-Phe6,Leu17]VIP and VIP(10-28); in contrast, the antagonist L-8-K was inactive.	d-phe2	98-104	vasoactive intestinal peptide	Homo sapiens	20-23
2475489-5	1989	For instance, [D-Phe6,Leu13,psi CH2NHLeu14]bombesin-(6-14) and des-Gly1-[D-Phe2,Leu9,psi CH2NHLeu10]neuromedin C exhibited IC50 values of 5 and 28 nM, respectively.	d-phe2	73-79	glyoxalase 1	Mus musculus	67-71
2904377-5	1988	LHRH caused a rapid increase in [Ca2+]i by about 50 nM which was blocked by the LHRH antagonist, [D-pGlu1,D-Phe2,D-Trp3,6] LHRH.	d-phe2	106-112	gonadotropin releasing hormone 1	Rattus norvegicus	80-84
2904377-5	1988	LHRH caused a rapid increase in [Ca2+]i by about 50 nM which was blocked by the LHRH antagonist, [D-pGlu1,D-Phe2,D-Trp3,6] LHRH.	d-phe2	106-112	gonadotropin releasing hormone 1	Rattus norvegicus	80-84
3384954-5	1988	The effect of CCK-8 was antagonized by dibutyryl cGMP (Bt2 cGMP) (10(-3) M), the VIP-antagonist (N-Ac-Tyr1, D-Phe2)-growth hormone-releasing factor-(1-29)-NH2, and abolished by tetrodotoxin.	d-phe2	108-114	cholecystokinin	Canis lupus familiaris	14-17
3081386-3	1986	This stimulatory action of LHRH was blocked by the addition of the specific antagonist ([D- pGlu1,D-Phe2,D-Trp3,6]LHRH).	d-phe2	98-104	gonadotropin releasing hormone 1	Rattus norvegicus	27-31
2879724-8	1987	The LHRH antagonist D-pGlu1, D-Phe2,D-Trp3,6-LHRH blocked the secretion of Dyn A1-13-IR, LH, and FSH induced by hpGHRH-(1-44), whereas the LHRH antagonist did not influence the simultaneous GH release elicited by hpGHRH-(1-44).	d-phe2	29-35	gonadotropin releasing hormone 1	Rattus norvegicus	4-8
2836826-3	1988	values suggested the coexistence, in near equal proportions, of two classes of VIP-preferring binding sites coupled to adenylate cyclase that showed similar decreasing affinity for: VIP greater than (D-Ala4)-VIP greater than (D-Asp3)-VIP = (D-Ser2)-VIP greater than (D-His1)-VIP greater than PHI greater than (D-Phe2)-VIP greater than (D-Phe4)-VIP.	d-phe2	310-316	vasoactive intestinal peptide	Homo sapiens	79-82
3081386-3	1986	This stimulatory action of LHRH was blocked by the addition of the specific antagonist ([D- pGlu1,D-Phe2,D-Trp3,6]LHRH).	d-phe2	98-104	gonadotropin releasing hormone 1	Rattus norvegicus	114-118
2862008-6	1985	The LHRH-stimulated release of Dyn A1-13-IR was mimicked by the LHRH analog D-Ala6,des-Gly10-LHRH ethylamide and blocked in a competitive manner by the LHRH antagonist D-pGlu1,D-Phe2,D-Trp3,6-LHRH.	d-phe2	176-182	gonadotropin releasing hormone 1	Rattus norvegicus	4-8
2994998-4	1985	The N-acetylated analog of GRF was as potent and active as the parent peptide, and the identity of the amino acid in position 2 of (N-Ac-Tyr1)-GRF(1-29)-NH2 proved to be determining for enzyme activation, with D-Phe2 and D-Trp2 derivatives acting as partial agonists and the (N-Ac-Tyr1,D-Arg2) analog being an efficient competitive antagonist of GRF(1-29)-NH2.	d-phe2	210-216	growth hormone releasing hormone	Rattus norvegicus	27-30
2997260-3	1985	A second GnRH antagonist [(D-pGlu1,D-Phe2,D-Trp3,6)-GnRH], however, was bound with a much lower affinity by the human receptor (Kd of 4.21 nM) than that of the rat (Kd of 0.09 nM).	d-phe2	35-41	gonadotropin releasing hormone 1	Homo sapiens	9-13
2997260-3	1985	A second GnRH antagonist [(D-pGlu1,D-Phe2,D-Trp3,6)-GnRH], however, was bound with a much lower affinity by the human receptor (Kd of 4.21 nM) than that of the rat (Kd of 0.09 nM).	d-phe2	35-41	gonadotropin releasing hormone 1	Homo sapiens	52-56
2862008-6	1985	The LHRH-stimulated release of Dyn A1-13-IR was mimicked by the LHRH analog D-Ala6,des-Gly10-LHRH ethylamide and blocked in a competitive manner by the LHRH antagonist D-pGlu1,D-Phe2,D-Trp3,6-LHRH.	d-phe2	176-182	gonadotropin releasing hormone 1	Rattus norvegicus	64-68
2862008-6	1985	The LHRH-stimulated release of Dyn A1-13-IR was mimicked by the LHRH analog D-Ala6,des-Gly10-LHRH ethylamide and blocked in a competitive manner by the LHRH antagonist D-pGlu1,D-Phe2,D-Trp3,6-LHRH.	d-phe2	176-182	gonadotropin releasing hormone 1	Rattus norvegicus	64-68
2862008-6	1985	The LHRH-stimulated release of Dyn A1-13-IR was mimicked by the LHRH analog D-Ala6,des-Gly10-LHRH ethylamide and blocked in a competitive manner by the LHRH antagonist D-pGlu1,D-Phe2,D-Trp3,6-LHRH.	d-phe2	176-182	gonadotropin releasing hormone 1	Rattus norvegicus	64-68
2862008-6	1985	The LHRH-stimulated release of Dyn A1-13-IR was mimicked by the LHRH analog D-Ala6,des-Gly10-LHRH ethylamide and blocked in a competitive manner by the LHRH antagonist D-pGlu1,D-Phe2,D-Trp3,6-LHRH.	d-phe2	176-182	gonadotropin releasing hormone 1	Rattus norvegicus	64-68
2862008-8	1985	An extract of the rat medial basal hypothalamus stimulated the release of Dyn A1-13-IR and beta-endorphin-like immunoreactivity, and the former, but not the latter, effect was blocked by the LHRH antagonist D-pGlu1,D-Phe2,D-Trp3,6-LHRH.	d-phe2	215-221	gonadotropin releasing hormone 1	Rattus norvegicus	191-195
2859987-7	1985	Substitution in GRF (or its N-acetylated derivative) by D-Phe2, D-Arg2, and D-Ala4 again reduced the intrinsic activity, whereas substitution of the natural L-amino acid residue by D-Ala2 and Phe4 gave superagonists.	d-phe2	56-62	growth hormone releasing hormone	Rattus norvegicus	16-19
3928012-5	1985	Pressor responses to LHRH and sLHRH were blocked completely by (D-pGlu1, D-Phe2, D-Trp3,6)-LHRH but this antagonist did not inhibit Ang II.	d-phe2	73-79	gonadotropin releasing hormone 1	Homo sapiens	21-25
3928012-5	1985	Pressor responses to LHRH and sLHRH were blocked completely by (D-pGlu1, D-Phe2, D-Trp3,6)-LHRH but this antagonist did not inhibit Ang II.	d-phe2	73-79	gonadotropin releasing hormone 1	Homo sapiens	31-35
6777114-0	1980	Inhibition of preovulatory gonadotropin secretion in the rhesus monkey by [(<Glu-Pro)1,D-Phe2,D-Trp3,6]-LHRH.	d-phe2	90-96	gonadotropin releasing hormone 1	Macaca mulatta	107-111
6202495-13	1984	The GnRH antagonist ( DpGlu1 , D-Phe2, D-Trp3,6) GnRH (1 microM) prevented both GnRH- and (Bu)2cAMP-induced increases in GnRH-R, although not that of 58 mM KCl.	d-phe2	31-37	gonadotropin releasing hormone receptor	Rattus norvegicus	121-127
2860571-4	1985	The LHRH-induced release of Dyn A1-13-IR was almost completely prevented by omission of calcium ions from the incubation medium or by addition of the LHRH-antagonist D-pGlu1,D-Phe2,D-Trp3,6-LHRH.	d-phe2	174-180	gonadotropin releasing hormone 1	Rattus norvegicus	4-8
6086269-4	1984	All peptides but D-Phe2, D-Trp3, D-Lys6-LH-RH which was noted to be an inhibitor were found to increase intracellular cAMP contents.	d-phe2	17-23	gonadotropin releasing hormone 1	Rattus norvegicus	40-45
376847-2	1979	In new and surprising relationships, it was found that the substitution of D-Trp into position 3 of [D- less than Glu1,D-Phe2,amino acid3,D-Phe6]-LH-RH significantly enhanced the antiovulatory potency, but substitution by Pro, N-Me-Phe,N-Me-Leu, or L-Trp reduced antiovulatory activity.	d-phe2	119-125	gonadotropin releasing hormone 1	Rattus norvegicus	146-151
23066921-6	2013	After GP ablation + CAB, Ach induced AF duration was determined in response to vasoactive intestinal peptide (VIP) and its specific antagonist ([Ac-Tyr1,D-phe2]-VIP).	d-phe2	153-159	vasoactive intestinal peptide	Canis lupus familiaris	161-164
17388516-9	2007	13C chemical shifts in the hydrophobic D-Phe2 residue are largely perturbed upon membrane binding, in the case where the side chain beta-CO2(-) in Asp4 is deionized; the deionization of Asp4 beta-CO2(-) increases the net hydrophobicity of achatin-I with a reduction of both the electrostatic hydration and the electrostatic attraction with the headgroup N(CH3)3(+) in the most superficial region of the PC membrane, resulting in deeper anchoring of the phenyl ring.	d-phe2	39-45	napsin A aspartic peptidase	Homo sapiens	147-151
17388516-9	2007	13C chemical shifts in the hydrophobic D-Phe2 residue are largely perturbed upon membrane binding, in the case where the side chain beta-CO2(-) in Asp4 is deionized; the deionization of Asp4 beta-CO2(-) increases the net hydrophobicity of achatin-I with a reduction of both the electrostatic hydration and the electrostatic attraction with the headgroup N(CH3)3(+) in the most superficial region of the PC membrane, resulting in deeper anchoring of the phenyl ring.	d-phe2	39-45	napsin A aspartic peptidase	Homo sapiens	186-190